text:
Home > Younger managers may chafe less about employment gaps than their elders, but they still feel the effect in their paychecks
Younger managers may chafe less about employment gaps than their elders, but they still feel the effect in their paychecks
During the past 10 or 15 years, corporate downsizing and widespread employee dismissals have spread beyond blue-collar ranks to include managers who earlier were largely immune from them. As a result, a new view has come to replace the earlier notion of managerial careers as uninterrupted climbs up the corporate ladder.
Indeed, some management thinkers have suggested that employment gaps, previously viewed as career handicaps, can have the net effect of increasing one's income in a new world of "protean" careers.
In a study presented at the 2003 annual meeting of the Academy of Management, Joy Schneer of Rider University and Frieda Reitman of Pace University explore whether employment gaps continue to take their toll on managers' income and whether younger managers respond to them differently than their elders did.
"Despite recent career views regarding the positive nature of protean careers and the prevalence of gaps, interruptions are still detrimental to a career as reflected in income penalties," Schneer and Reitman conclude. What has changed, however, is the attitude of younger managers, particularly men, to these gaps.
"It appears that men who experienced a gap two decades ago perceived it as a career failure, but those in the recent cohort no longer feel that way."
The findings are based on a six-page survey sent to randomly selected alumni who received MBAs from two northeastern universities. An "early cohort" consisted of 777 alumni who received their MBAs between 1977 and 1981 and responded to the survey in 1987; a "recent cohort" consisted of 400 alumni who received the degree between 1990 and 1994 and were surveyed in 2000. Both cohorts were about evenly divided between men and women, and the average age in each was 38.
Gaps -- voluntary and involuntary alike -- were reported by 22% of the early cohort and 18% of the recent cohort, with the average gap for each group being about eight months. For both groups, gaps carried a substantial penalty in terms of annual income at survey time, with those in the early cohort earning on average 25% less and those in the recent cohort 18 percent less than fellow alumni who had worked continuously. But whereas in the early cohort men with employment gaps were significantly less satisfied with their careers than those who had worked continuously, in the recent cohort gaps were not linked to a fall-off in satisfaction among either men or women.
Seeking reasons for this, the authors surmise that there may be "a new appreciation that the traditional managerial ladder is not the only acceptable career path."
But they also note that the career gaps of the recent cohort occurred mainly during the bull market of the 1990s, when managers might be more complacent about career gaps than at other times. As the authors put it, "It will be interesting to see whether the gap effects that were found at the peak of an economic expansion and an era of optimism continue as the phases of the business cycle go forward and as the globalization of industry continues."
The Academy of Management, founded in 1936, is the largest organization in the world devoted to management research and teaching. It has over 13,000 members in 90 countries, including some 9,000 in the United States. The academy's 2003 annual meeting drew some 6,000 scholars and practitioners to Seattle for more than 1,000 sessions on a host of issues relating to corporate organization, the workplace, technology development, and other management-related subjects.


The Jali Natural Nest of 3 Coffee Tables is a charming piece of Solid Wood Furniture design destined to be a feature in your living room. Each unit comes with 3 nesting tables which can be used separately as a lamp table, side table or temporality console table, with all 3 slotting together when not in use.
The Jali Natural Nest of Tables is made from only the finest Indian Sheesham Wood which retains its natural wood finish that compliments each unit's Indian Jali inspired iron cast detailing.
The Jali Natural Nest of 3 Coffee Tables are also available in a light and dark finish.


It had been rumored for sometime that Google might open up the VP8 video codec after the acquisition of On2 Technologies, the codec's creator. Today at the I/O conference, Google confirmed the rumor with the announcement of the WebM Project.
The WebM Project, a venture supported by Mozilla, Opera, Google and at least 40 additional publishers, uses the VP8 video codec and the Vorbis audio codec to create high quality video and audio without the copyrights and patents associated with the h2.64 format championed by Apple and Microsoft.
From the ground up WebM files are designed to work on a variety of devices including netbooks and smartphones. In addition to the open encoders, WebM uses the Matroska container, which supports streaming, subtitles, chapter notations, menus and multiple audio channels.
The WebM Project operates under a BSD-style license where the VP8 bitstream is free and can be modified, sold and imported, but can be revoked, should patent litigation be pursued. For more information on the WebM Project, visit webmproject.org.


text:
Q: Excel VBA finding matching cell in another sheet in same book Basically this sheet works wonderfully with the exception of the find priority part...
I need it to find the matching value inside the corresponding sheet, then return the row number it's in, so that I can paste values into the cell to the right of the found cell.
However, when I run this VBA (I have to comment it entirely out to keep from destroying the excel sheets entirely), the cells are 1 off and there are these randoms wound up in the bottom of the sheet (in "no man's land"). I have tried increasing and decreasing the value that holds the row identity to see if it would fix that part of my issue, but no such luck.
Anyway, here's the code in it's broken fashion:
Private Sub Workbook_Open()
'connection to database
Dim userEmpId As String
Dim sSQL As String
userEmpId = InputBox(Prompt:="Employee ID.", Title:="ENTER EMPLOYEE ID", _
            Default:="A1JW7ZZ")
sSQL = "SELECT * FROM OP_TRAIN; "
Dim rs As ADODB.Recordset
Dim cn As ADODB.Connection
Set cn = New ADODB.Connection
cn.Open "Provider=Microsoft.ACE.OLEDB.12.0;Data Source=I:\MANUFACTURING\Six Sigma Projects\Green Belt Projects 2012\Hebron Training Plan\3m hebron training.accdb;Persist Security Info=False"
Set rs = New ADODB.Recordset
rs.Open sSQL, cn
ActiveWorkbook.Sheets("Employee Training").Cells(1, 1).CopyFromRecordset rs
rs.Close
Set rs = Nothing
cn.Close
Set cn = Nothing
Worksheets("Employee Training").Activate
Dim Bottom As Integer
Dim CopyRange As String
Bottom = CInt(Cells(Rows.Count, "A").End(xlUp).Row) 'initializes the bottom of the list (total number of entries)
CopyRange = "A1:G" & Bottom 'Total data range

Do Until Bottom = 0 'loop until out of data
    ActiveSheet.Cells(Bottom, 1).Select 'selects column A of the current row
    If (Selection.Text <> userEmpId) Then
        Range(CopyRange).Rows(Bottom).Delete Shift:=xlUp
    End If
    Bottom = Bottom - 1
Loop
Bottom = CInt(Cells(Rows.Count, "A").End(xlUp).Row) 'initializes the bottom of the list (total number of entries)
Dim FoundRow As Integer
Do Until Bottom = 0 'loop until out of data
    'ActiveSheet.Cells(Bottom, 2).Select 'selects column B of the current row
    Select Case Selection.Text
        Case "1A"
            ActiveSheet.Cells(Bottom, 3).Select 'selects column C of the current row
            FoundRow = FindPriority(Selection.Value)
            'ActiveSheet.Cells(Bottom, 4).Select 'selects column D of the current row
            Selection.Copy
            Worksheets("OP1A-OP1B").Activate
            Cells(FoundRow, 4).Select
            Selection.PasteSpecial Paste:=xlPasteValues, _
                  Operation:=xlNone, SkipBlanks:=False, Transpose:=False
        Case "1B"
            ActiveSheet.Cells(Bottom, 3).Select 'selects column C of the current row
            FoundRow = FindPriority(Selection.Value)
            'ActiveSheet.Cells(Bottom, 4).Select 'selects column D of the current row
            Selection.Copy
            Worksheets("OP1B-OP1C").Activate
            Cells(FoundRow, 4).Select
            Selection.PasteSpecial Paste:=xlPasteValues, _
                  Operation:=xlNone, SkipBlanks:=False, Transpose:=False
        Case "1C"
            ActiveSheet.Cells(Bottom, 3).Select 'selects column C of the current row
            FoundRow = FindPriority(Selection.Value)
            'ActiveSheet.Cells(Bottom, 4).Select 'selects column D of the current row
            Selection.Copy
            Worksheets("OP1C-OP2A").Activate
            Cells(FoundRow, 4).Select
            Selection.PasteSpecial Paste:=xlPasteValues, _
                  Operation:=xlNone, SkipBlanks:=False, Transpose:=False
        Case "2A"
            ActiveSheet.Cells(Bottom, 3).Select 'selects column C of the current row
            FoundRow = FindPriority(Selection.Value)
            'ActiveSheet.Cells(Bottom, 4).Select 'selects column D of the current row
            Selection.Copy
            Worksheets("OP2A-OP2B").Activate
            ' Cells(FoundRow, 4).Select
            Selection.PasteSpecial Paste:=xlPasteValues, _
                  Operation:=xlNone, SkipBlanks:=False, Transpose:=False
        Case "2B"
            ActiveSheet.Cells(Bottom, 3).Select 'selects column C of the current row
            FoundRow = FindPriority(Selection.Value)
            'ActiveSheet.Cells(Bottom, 4).Select 'selects column D of the current row
            Selection.Copy
            Worksheets("OP2B-OP2C").Activate
            Cells(FoundRow, 4).Select
            Selection.PasteSpecial Paste:=xlPasteValues, _
                  Operation:=xlNone, SkipBlanks:=False, Transpose:=False
        Case "2C"
            ActiveSheet.Cells(Bottom, 3).Select 'selects column C of the current row
            FoundRow = FindPriority(Selection.Value)
            'ActiveSheet.Cells(Bottom, 4).Select 'selects column D of the current row
            Selection.Copy
            Worksheets("OP2C-OP3A").Activate
            Cells(FoundRow, 4).Select
            Selection.PasteSpecial Paste:=xlPasteValues, _
                  Operation:=xlNone, SkipBlanks:=False, Transpose:=False
        Case "3A"
            ActiveSheet.Cells(Bottom, 3).Select 'selects column C of the current row
            FoundRow = FindPriority(Selection.Value)
            'ActiveSheet.Cells(Bottom, 4).Select 'selects column D of the current row
            Selection.Copy
            Worksheets("OP3A-OP3B").Activate
            Cells(FoundRow, 4).Select
            Selection.PasteSpecial Paste:=xlPasteValues, _
                  Operation:=xlNone, SkipBlanks:=False, Transpose:=False
        Case "3B"
            ActiveSheet.Cells(Bottom, 3).Select 'selects column C of the current row
            FoundRow = FindPriority(Selection.Value)
            'ActiveSheet.Cells(Bottom, 4).Select 'selects column D of the current row
            Selection.Copy
            Worksheets("OP3B-OP3C").Activate
            Cells(FoundRow, 4).Select
            Selection.PasteSpecial Paste:=xlPasteValues, _
                  Operation:=xlNone, SkipBlanks:=False, Transpose:=False
        Case "3C"
            ActiveSheet.Cells(Bottom, 3).Select 'selects column C of the current row
            FoundRow = FindPriority(Selection.Value)
            'ActiveSheet.Cells(Bottom, 4).Select 'selects column D of the current row
            Selection.Copy
            Worksheets("OP3C-SOP").Activate
            Cells(FoundRow, 4).Select
            Selection.PasteSpecial Paste:=xlPasteValues, _
                  Operation:=xlNone, SkipBlanks:=False, Transpose:=False
    End Select
    Worksheets("Employee Training").Activate
    Bottom = Bottom - 1
Loop
End Sub

THIS IS THE PROBLEMATIC CODE
 Function FindPriority(priority As Integer) As Integer
 Dim ws As Excel.Worksheet
 Dim FoundCell As Excel.Range
 Set ws = ActiveSheet
 Set FoundCell = ws.Range("C:C").Find(what:=priority, lookat:=xlWhole)
 FindPriority = FoundCell.Row
 End Function

A: One thing you can try is the MATCH command.  You access it in VBA as follows:
FindPriority = Application.WorksheetFunction.Match(priority,ws.Range("C:C"),0)

This will return the row number for you in your function.

A: ActiveSheet.Range("C:C").Find(priority, , xlValues, xlWhole).Row

using the find function in conjunction to the row counter SOLVED MY ISSUE!!
Thanks Mike for pointing me in a better direction (in a sense I never would've dug deeper without you shining some light)

redpajama_set_name: RedPajamaStackExchange


This painting of the Isaac H. Evans was inspired by the old ship paintings of the 1800's. Many of the Antonio Jacobson and Buttersworth paintings of ships were done portrait style, directly from the starboard or port side of the ship. I liked the lines of the ship so much I thought it deserved to be captured portrait style! She is over one hundred years old and still sails out of Rockland, Maine. She is a true treasure.


What is it to breathe with intention? Being intentional in every thought, word, and action you express.
To be honest, this is only a part of what it means to breathe with intention. I certainly thought I understood the concept well, but as I'll share with you here, my understanding has truly evolved, and so have I as a spiritual being. With that said, I'd like to welcome you into my personal space and encourage you to delve deeper into your personal journey and consciously breathe with intention throughout all aspects of your life. With my experience abroad, I have begun mentoring others through their own emotional journey's; you can check out more of that on my soul essential travel mentorship page.
Nothing becomes easier in life; what does is our ability to learn how to adapt better to the obstacles that are placed in front of us. There's no magic formula or way to simply snap our fingers and have everything manifest in an instant, but with persistence and clear intentions for what you hope to achieve, you'll reach all of our goals without letting failure stop you in your tracks.
I use to think that every breath I took was full of intention but it wasn't until I traveled to the Balkans for the first time, in 2015, that I began to fully become conscious of the breath, by way of the action, the inhale and exhale, the moment when you completely embrace. It was in this moment in Montenegro, where I truly started to take a 100% active part of my life. It was the moment I finally began waking every living cell inside of me.
For anyone not familiar with my time abroad, I'll do my best to take you through my journey, how I left my country, thinking I was open, adventurous and all the other things you tell yourself you are as you get on the plane and embark on your first living abroad experience. I have become all the things I use to think I was but only dreamt of and there's still much more to learn and become. It's only now that when I look back I can see how much of a prude I was, partially judgemental of certain peoples' way of life and untrusting of many of those around for no other reason then it seemed like how I needed to be to protect myself.
I am sharing my story and journey because I genuinely believe that experiences whether they are filled with joy, sorrow, heartbreak, or a combination, are all more enjoyable, tolerable, bearable, and exciting when shared.
What I aim to do here is open the door on my experiences and inspire by allowing a very personal insight to my life while trying to sprinkle in some helpful travel hacks and methods on how to best maximize your travel moments by breathing with intention through each and every experience you have. The secret is out, taking every moment in life and breathing through it with intention, making a promise to yourself to take an active part in your journey; this is how I have been able to find true happiness, and I hope you will find the same. I now provide emotional support to other travelers through my soul essential travel mentorship.
I won't force you to read all of the entries here in full, I actually encourage the expression of enthusiasm so much that whenever you feel inspired to get up and experience, you do it. If you feel like writing about your adventures and sending them into me even better; let's start the flow of inspiration. I encourage you to find your own journey rather than follow mine or anyone else's, I guarantee it will be much more fulfilling. Take all the inspiration you need from here and use it to begin creating your own unique story.
With that said, I invite you all on a journey with me; there will be a few somber moments, many that will have you questioning my sanity and several that will leave you wanting to stop reading, jump up and act upon your dreams.
Feel the blog, enjoy it, and I hope it brings out the best in you.


I was searching for a Property and found this listing (MLS® #190008205). Please send me more information regarding 3805 Alder Ave, Carlsbad, CA, 92008. Thank you!
I'd like to request a showing of 3805 Alder Ave, Carlsbad, CA, 92008 (MLS® #190008205). Thank you!


text:
Talentos para Verificar:
* Ataque Poderoso;
* Tiro Multiplo;
* Especialização em Combate;
* Piranha Strike
* Rajada de Golpes

-BUG: pericias com atributos errados
-BUG: concentração foi removido sem querer.

Versão 0.7
- Campos editaveis invisiveis tem retangulo diferenciado agora.
- Aba de habilidades compativel com aparelhos moveis.
- Aba de anotações compativel com aparelhos moveis.
- Se a lista de pericias estiver vazia a lista padrão vai ser automaticamente colocada.

Versão 0.6
- Botão para apagar um ataque simples.
- Seleção cores temas da ficha.
- Realizar um ataque simples mesmo com tudo vazio não vai mais dar erros.
- Removida aba antiga de equipamentos.
- Função de import e export atualizada.
- Interface de itens consumiveis atualizada.
- Adicionado espaço para proezas nas habilidades, separado dos talentos.

Versão 0.5
+ Nova aba de equipamentos.
+ Colocado um campo para notas no lugar da CA oculta.
+ Removidas magias diarias de nível 0.
+ Ataques não confirmam falhas criticas.
+ Trocado Agarrar por BMC nos companheiros.
+ Corrigido bug ao ativar "composto" nos ataques avançados sem antes por o valor de limite.
+ Nova forma de formatar preço e peso.
+ Nova forma de formatar xp.
WARNING: Copie seus equipamentos para a nova aba, antes de ir para a versão 6.

Versão 4:
+ Bug corrigido: quando o personagem está usando armadura não estava contabilizando o +3 em pericias de classe com graduações.

Versão 3:
+ Ajustados os nomes de multiplos campos de acordo com a tradução oficial.
+ Adicionadas pericias que estavam faltando (geografia e linguistica).
+ Ajustado funcionamento de ataque poderoso.
+ Espaço nas magias para teste de concentração (nc+atr+out)

Versão 2:
- Corrigido bug com a qualidade das armas nos ataques avançados.
- Opção para exportar e importar ficha para um arquivo xml (aba creditos).

Versão 1: Adaptação da ficha RPGmeister para Pathfinder.
- Pericias agora seguem a regra de pathfinder apenas.
- Novo slot de testa adicionado. Slot de corpo dividido em dois (Corpo e Armadura).
- Mudada regra de XP para a (maldita) tabela (sem regra) de Pathfinder.
- BMC/BMD aprimorados para considerar bônus especificos para cada manobra.
- Nota: bem provavel que muita coisa dos ataques avançados não esteja adequada a Pathfinder. Reportem tudo que encontrarem de errado ou que precisa ser adicionado e será corrigido
- Nota 2: Se você estava usando a ficha RPG meister para jogar Pathfinder, não se preocupe. Elas são compativeis. Exporte a ficha que está usando e importe na ficha nova.

redpajama_set_name: RedPajamaGithub


text:
using System.Net;
using Microsoft.VisualStudio.TestTools.UnitTesting;
using ViridiX.Linguist.Network;
using ViridiX.Mason.Logging;

namespace ViridiX.Linguist.Tests
{
    [TestClass]
    public static class AssemblyGlobals
    {
        public static ILogger Logger;

        public static XboxConnectionInformation TestXbox =
            new XboxConnectionInformation(IPAddress.Parse("10.231.50.79"), "abc");

        [AssemblyInitialize]
        public static void Initialize(TestContext testContext)
        {
            Logger = new SeriLogger(LogLevel.Trace);
        }

        [AssemblyCleanup]
        public static void Cleanup()
        {
            Logger?.Dispose();
        }
    }
}


Moon phase on 5 November 2014 Wednesday is Waxing Gibbous, 13 days young Moon is in Aries.
Waxing Gibbous is the lunar phase on 5 November 2014, Wednesday . Seen from Earth, illuminated fraction of the Moon surface is 97% and growing larger. The 13 days young Moon is in ♈ Aries.
Previous main lunar phase is the First Quarter before 5 days on 31 October 2014 at 02:48.
Lunar disc appears visually 0.5% narrower than solar disc. Moon and Sun apparent angular diameters are ∠1925" and ∠1936".
Next Full Moon is the Beaver Moon of November 2014 after 1 day on 6 November 2014 at 22:23.
The Moon is 13 days young. Earth's natural satellite is moving from the first to the middle part of current synodic month. This is lunation 183 of Meeus index or 1136 from Brown series.
2 days after point of perigee on 3 November 2014 at 00:21 in ♓ Pisces. The lunar orbit is getting wider, while the Moon is moving outward the Earth. It will keep this direction for the next 9 days, until it get to the point of next apogee on 15 November 2014 at 01:56 in ♌ Leo.
Moon is 372 277 km (231 322 mi) away from Earth on this date. Moon moves farther next 9 days until apogee, when Earth-Moon distance will reach 404 338 km (251 244 mi).
Moon is in descending node in ♈ Aries at 03:13 on this date, it crosses the ecliptic from North to South. Moon will follow the southern part of its orbit for the next 13 days to meet ascending node on 19 November 2014 at 08:18 in ♎ Libra.
13 days after beginning of current draconic month in ♎ Libra, the Moon is moving from the middle to the last part of it.
8 days after previous South standstill on 28 October 2014 at 01:03 in ♐ Sagittarius, when Moon has reached southern declination of ∠-18.539°. Next 4 days the lunar orbit moves northward to face North declination of ∠18.575° in the next northern standstill on 9 November 2014 at 23:12 in ♊ Gemini.
After 1 day on 6 November 2014 at 22:23 in ♉ Taurus, the Moon will be in Full Moon geocentric opposition with the Sun and this alignment forms next Sun-Earth-Moon syzygy.


This is just so awesome. I feel like I'm standing right there, wrapped up in my warm jacket, watching intently as Francesco scales ice! That feels impossible, right? Ice climbing? What a cool thing to do. What really makes this awesome moment even more visually interesting is the background layer of the structures climbing up the mountain in the background. I love it!


text:
Siegmund Ritter von Benigni in Müldenberg (seit 1917 Graf von Benigni in Müldenberg; * 15. Jänner 1855 in Fiume, Kaisertum Österreich; † 13. Oktober 1922 in Graz) war ein österreichischer Feldzeugmeister und Truppenführer im Ersten Weltkrieg.

Leben
Siegmund Ritter von Benigni in Müldenberg war nach Absolvierung der k.u.k. Technischen Militärakademie 1873 zum Leutnant im k.u.k. Genieregiment 1 in Olmütz ausgemustert worden. Nach Absolvierung des höheren Geniekurses wurde er als Oberleutnant 1880 dem Generalstab zugeteilt und zum Stab der 32. Infanteriebrigade in Hermannstadt versetzt. Im Wechsel von Generalstabs- und Truppenverwendungen erreichte er 1882 die Beförderung zum Hauptmann, 1893 zum Major und 1898 zum Oberstleutnant. Von 1898 bis 1902 war er Kommandant der Infanteriekadettenschule in Preßburg. 1901 wurde er Oberst und war von 1902 bis 1904 Kommandant des  Infanterieregiments Nr. 19, von 1904 bis 1907  Kommandant des Bosnisch-Herzogewinischen Infanterieregiments Nr. 2. Seit April 1907 war er Kommandant der 19. Infanteriebrigade, wurde aber im August zur 2. Gebirgsbrigade nach Trebinje versetzt. Im November 1907 wurde er Generalmajor und 1911 Feldmarschallleutnant. Nun endete vorläufig seine aktive Dienstzeit und er wurde auf "Wartegebühr" gesetzt.

Im Ersten Weltkrieg
Als der Erste Weltkrieg ausbrach, wurde er alsbald reaktiviert und führte von Jänner bis März 1915 die 45., und von März bis Juni die 15. Infanterietruppendivision in den Karpaten als ein Teil der Armeegruppe Pflanzer-Baltin. Am 7. Mai 1915 wurde er zum  Feldzeugmeister  befördert. Im Juli 1915 wurde während des Höhepunktes der Sommeroffensive gegen Russland das Korps Benigni gebildet. Diesen Verband führte er über ein Jahr, bis im Juli 1916 das Korps in VIII. Korps umbenannt wurde. Dieses Korps führte er bis März 1918, als er von General der Infanterie Emmerich Hadfy abgelöst wurde. Von da an bis Oktober 1918 war er Militärkommandant von Krakau. Aufgrund ihrer Verdienste waren er und seine Brüder bereits am 16. August 1917 in den Grafenstand erhoben worden.

Im Tode
Er ist am 13. Oktober 1922 verstorben und liegt am Stadtfriedhof Graz-St. Peter begraben.

Österreichische Militärauszeichnungen (Stand 31. Dezember 1918)
 Mobilisierungskreuz 1912/13
 Bosnisch-Hercegovinische Erinnerungsmedaille
 Militär-Jubiläumskreuz 1908
 Militär-Jubiläumsmedaille 1898
 Dienstzeichen für Offiziere II. Klasse
 Militärverdienstkreuz III. Klasse
  Ehrenzeichen 1. Klasse Rotes Kreuz, Kriegsdekoration
  Leopoldorden Ritterkreuz, Kriegsdekoration mit Schwertern
 Orden der Eisernen Krone Ritter II. Klasse, Kriegsdekoration mit Schwertern
 Militärverdienstkreuz II. Klasse, Kriegsdekoration mit Schwertern
 Orden der Eisernen Krone Ritter I. Klasse, Kriegsdekoration mit Schwertern
 Leopoldorden 1. Klasse, Kriegsdekoration mit Schwertern

Einzelnachweise

Literatur

Befehlshaber im Ersten Weltkrieg (Österreich-Ungarn)
Feldzeugmeister (Österreich-Ungarn)
Träger des Österreichischen Militärverdienstkreuzes II. Klasse
Träger des Ordens der Eisernen Krone (II. Klasse)
Träger des ö.k. Leopold-Ordens (Ritter)
Person (Cisleithanien)
Österreicher
Geboren 1855
Gestorben 1922
Mann

redpajama_set_name: RedPajamaWikipedia


A well needed second shower was designed into this basement. A nice combination of burgundy and blue-grays create a nice backdrop for this space in need of a makeover. Also added drawers that double as steps in order to access the crawl that will be covered by a mirrored door.


Gordian III, 238-244. As (Copper, 24 mm, 9.39 g, 1 h), Rome, 240. IMP GORDIANVS PIVS FEL AVG Laureate, draped and cuirassed bust of Gordian III to right, seen from behind. Rev. LAETITIA AVG N / S - C Laetitia standing front, head to left, holding wreath in her right hand and rudder with her left. Cohen 123 var. (not cuirassed). RIC 300b. Light deposits, otherwise, about very fine.
From the G.G. Collection of Roman Imperial third century middle bronzes.


text:
San Angelo Writers Club
Best Writing in West Texas
Writer's Pages
Tag: Writing	(page 1 of 2)
Bruce Partain
April 12, 2019 / John Osterhout / 0 Comments
Bruce Partain, President and CEO of the San Angelo Chamber of Commerce, spoke on "Writing About San Angelo for Traditional Publications and Other Media" at the April 9 meeting of the San Angelo Writers Club. He discussed writing for traditional media as well as for blogs and social media. According to Partain, his motivation was to get more well-written stories about San Angelo into publications across the state and world.
Partain gave examples of writing assignments from his own experience and that of others. He discussed various types of writing: general features, travel features, profiles, and industrial news and updates. Noting the the Chamber of Commerce was a resource for writing examples and stock photos of San Angelo, he encouraged our membership to work on the on line presence. Finally, he discussed a set of electronic tools that he found useful for interviewing and organizing materials.
Partain provided two handouts, which are available below.
Bruce Partain – Presentation Outline
Ripped Jeans and Bifocals example.
Dr. Terry Dalrymple
March 16, 2019 / John Osterhout / 0 Comments
by Laurel Scott
Dr. Terry Dalrymple of Angelo State University's English department, spoke on "The Long and Short of Short Story Writing" at the Feb. 12 meeting of the San Angelo Writers Club. He discussed the wide variety of writing that can fall within the description "short story," from "flash fiction," stories as no longer than 1,000 words, to the novella, which can be as long as 50,000 words. The standard short story is defined as 1,500 to 30,000 words in length by Writers Digest. But Dalrymple said not to focus on length.
"I don't think it makes much difference. If it's a good story, it's a good story." He said flash fiction is very popular currently in literary magazines and journals but said, "It's so much harder to write an 800-word story."
Rapt Audience
He also talked about inspiration and what fiction is and is not. He and two other authors, Jerry Craven and Andrew Geyer, did what is known as a short story cycle of four stories by each writer, for a total of 12, that had to connect in some way. Titled "Dancing on Barbed Wire."
"It was an interesting thing to do and it inspired me." He said he "hears voices," pieces of dialogue or description that can turn into a short story. One example he gave was writing a story just from the word on a car license plate. He emphasized, though, that ideas don't make a story, characters do. And he said fiction is not about creating, it's about re-creating.
"We don't create out of nothing, like God created light. We re-create. Fiction is like counterfeit money, it is supposed to look like the real thing even though it's not." He emphasized that the elements of fiction — character, plot, point of view and setting — also includes believe-ability.
He concluded with one piece of "major advice": at least one character has to be a complex human being and quoted the phrase "friction equals fiction."
Laurence Musgrove
January 11, 2019 / John Osterhout / 2 Comments
At the January 8th meeting, Dr. Laurence Musgrove, author of books of poetry and chair of the Angelo State University Department of English, presented "The Five Sources of Beauty in Poetry."
Musgrove began by listing the five sources: shape, line, voice, repetition, and analogy. It is usually easy to spot poetry on the page: it is not a solid block of text like prose. Poetry on the page takes different shapes: long lines that extend almost across the page or skinny lines snaking down the page or lining the edges. The shape of the poem often hints at its style. Long lines implying perhaps description or observation, short lines providing contrast or emotion.
Manning Wolf
October 10, 2018 / John Osterhout / 0 Comments
On October 9, 2018, Manning Wolf, attorney and author, spoke to the San Angelo Writers Club about plotting and writing the thriller. Manning told the group about writing in three acts, each composed of a series of beats that define the progress of the work. She advised allotting a quarter of the pages to Act I, which introduces the characters, the locale, and sets the tone of the novel. Another quarter of the pages are assigned to the slam-bam finish in Act III, leaving fully half of the book for the middle, Act II, where the plot thickens and character development occurs.
Manning Wolf is an author, blogger, and attorney based in Austin. Manning writes fast-paced legal thrillers (she's an attorney, remember) starring Austin attorney Merit Bridges. Enthusiastic readers note that the detailed use of Austin sights and restaurants make the city a character in its own right. Her Lady Lawyer novels include Dollar Signs, Music Notes, and Green Fees. All are available on Amazon in paperback and as Kindle books.
Manning's Books
Dollar Signs. Merit Bridges represents a client accused of arson and murder after taking matters into his own hands. When Merit steps in, her ruthless opponents unleash a merciless hired gun, Boots King, to head her off at the pass. The ensuing legal shenanigans, a wild chase across Texas, and the looming presence of Boots King make for a wild ride!
Manning Sells Some Books
Music Notes. Liam Nolan was getting his life back together, cataloging his music. Things are looking up until someone murders him with his own guitar. Then a heir shows up claiming to be Liam's illegitimate son. Meanwhile, Nolan's former manager, L. A. Baron, makes a play for the estate and starts making shady deals for the estate. The maneuvering in and out of court has Merit Bridges looking over her shoulder.
Green Fees. Golf pro Mark Green has a problem. To keep his PGA tour dream alive he borrowed money from Russian loan shark Browno Zars (not a good life choice). This is a problem because when Bruno doesn't get his money he gets testy and when Bruno gets testy, his henchman, the Enforcer, gets busy. Mark asks his lover, the smart and feisty attorney Merit Bridges, for help. Merit goes to work with her legal magic. This makes her a target for the Enforcer. Merit wakes up hanging from a meat hook and staring death in the face. Can Merit save herself from torture and certain death?
Manning and Her SAWC Fans
Kathy Keaton – Writing Humor
May 14, 2018 / John Osterhout / 0 Comments
Kathy Keaton
Kathy Keaton, aka Piccolo the Clown, gave the May San Angelo Writers Club (SAWC) program on writing humor. The occasion for her talk was the recent publication of her new book Prescription Humor: The Compassionate Application of Medicinal Humor. For the last 15 years, Kathy has been employed at the San Angelo Community Medical Center as a Therapeutic Hospital Clown.
Kathy as Piccolo
Kathy Keaton is a motivational and keynote speaker. Her message is timeless: laughter can help us lead a happier and healthier life. In her book and speaking appearances she gives examples of the positive effcts of laugher on our well-being. Her alter ego, Piccolo, is an award-winning clown. Kathy is a board member of the Texas Clown Association and a member of the World Clown Association. After three-years of study at the Humor Academy of the Association of Applied and Therapeutic Humor, she was one of the first to be awarded a designation as a Certified Humor Proessional (CHP).
In her talk, Kathy admonished us to better understand our own sense of humor in order to blend it into the characters in our books. From Kathy's handout: "A sense of humor is a powerful tool/trait that can be used to add depth to your writing as well as help you connect with others in the real world plus add health benefits for you life." She suggested that we keep a humor notebook to help us define our sense of humor and to construct humorous situations for our characters.
Kathy's book Prescription Humor: The Compassionate Application of Medicinal Humor was published in January 2018 and available on Amazon. The book is a collection of life stories collected from over forty years of experience. Her message is that humor and personel connection can improve even the most difficult situations. It is about using humor to provide moments of laughter and bring relief to the stress of difficult situations.
Kathy Signing Her Book
During her presentation Kathy had the club members stand and led us in exercises to limber up our funny bones and to improve our health and attitudes. Kathy lingered after the meeting to sign books and chat with the members. Connect with Kathy Keaton/Piccolo the Clown on her website.
SAWC Holiday Party a Success
December 14, 2017 / John Osterhout / 0 Comments
Stan Denny is first in line.
The SAWC Holiday Party was held December 12 at First Place, 14 Harris Street, San Angelo, Texas. Coffee and "snacks" started at 6:30 pm. Only instead of snacks, there was a holiday spread that was quite impressive (see the picture at right). The picture shows Stan Denny, resplendent in his read coat, leading off the charge on the food. For a while, the members settled down to talking and chewing.
Dana Glossbrenner leads off.
After sufficient attention was paid the scrumptious food, President Mattie McKee opened the floor to readings from the members. The business meeting and reading started late because, well, we couldn't talk with our mouths full.
Each member was allowed 5-10 minutes to read from his or her recent writing. The evening's presentations included poetry, selections from novels, excerpts from memoirs, and a poem from a collection of poem-prayers.
Members pose for group photo.
After the individual presentations the members and new members posed for a photo. The evening closed with best wishes for all for the holiday season and the new year. Join us in 2018 for another great year of the San Angelo Writer's Club.
Also, visit the holiday party gallery.
Brian Turner to be Featured at Writer's Conference
December 6, 2017 / John Osterhout / 0 Comments
Brian Turner will be the featured writer at the 22nd Annual ASU Writers Conference in Honor of Elmer Kelton. See the Writer's Conference home page here.
Mr. Turner is a poet and memoirist who served seven years in the US Army. He is the author of two poetry collections, Phantom Noise and Here, Bullet, which won the 2005 Beatrice Hawley Award, the New York Times "Editor's Choice" selection, the 2006 PEN Center USA "Best in the West" award, the 2007 Poets Prize, and others. Turner's work has been published in National Geographic, The New York Times, Poetry Daily, Harper's Magazine, and other fine journals. Turner has been awarded a United States Artists Fellowship, an NEA Fellowship, a Lannan Foundation Fellowship, and more. His recent memoir, My Life as a Foreign Country, has been called, "achingly, disturbingly, shockingly beautiful."
Visit Brian Turner's author page at Blue Flower Arts.
Lone Star Literary Life
August 13, 2017 / John Osterhout / 0 Comments
If you love writing and live in Texas, you should know about Lone Star Literary Life. Lone Start Literary Life is the brainchild of Kay Ellington and Barbara Brannon, former speakers for the San Angelo Writers Club.
Here are two excerpts from their web page:
Lone Star Literary Life is dedicated to the idea that Texas readers and writers deserve their own lair—a virtual speakeasy of letters where wordsmiths and bookworms are embraced as part of our state's reading and writing community. So, howdy and welcome. You seem like our kind of folks.
With Lone Star Literary Life, if you don't know about Texas books, it'll be your own fault.
Visit the site. There are reviews, e-newsletters, book blog tours, podcasts, calendars of book event, stories, photos, and interviews.
Matt de la Pena
July 11, 2017 / John Osterhout / 0 Comments
Matt de la Peña will be the featured guest at a Meet the Author event at 2 pm, Tuesday, July 18, in the Suggs Community Room of the Stephens Central Library, 33 W. Beauregard, San Angelo.
Matt de la Peña is the New York Times bestselling author of young adult novels. His titles include "The Hunted," "We Were Here" and "Mexican Whiteboy." He won the 2016 Newberry Medal for his picture book "Last Stop on Market Street".
Matt is a native of San Diego, California. He received his BA from the University of the Pacific and his MFA in creative writing from San Diego State University. He currently lives in Brooklyn, NY with his family and teaches creative writing at New York University
Visit Matt's website, mattdelapena.com.
Thanks to Laurel Scott for initiating this post.
April – Cynthia Jordan
June 21, 2017 / John Osterhout / 0 Comments
Cynthia Jordan talked with the San Angelo Writers Club about her new book, Ruby, the third book in her Gem Trilogy, which also includes Pearl and Diamond. Cynthia also talked about sources of inspiration for her literature and her music.
Members Read
Dana Glossbrenner
Dr. John Osterhout
John Osterhout on Laurence Musgrove
Jeff Dowdy on Laurence Musgrove
The San Angelo Writers Club meets the second Tuesday of every month at First Place, 14 Harris Street, San Angelo, Texas. Coffee and snacks are served at 6:30 pm and the presentations begin at 7:00 pm. Membership is $20.00 per year.
© 2019 San Angelo Writers Club

redpajama_set_name: RedPajamaCommonCrawl


text:
rs12512631 on the Group Specific Complement (Vitamin D-Binding Protein GC) Implicated in Melanoma Susceptibility
Maria Peña-Chilet,
Affiliation Medical Oncology and Haematology Unit, Health Research Institute INCLIVA, Valencia, Spain
Maider Ibarrola-Villava,
Manuel Martin-González,
Affiliation Dermatology Department, Ramon y Cajal Hospital, Madrid, Spain
Marta Feito,
Affiliation Dermatology Department, La Paz University Hospital, Madrid, Spain
Cristina Gomez-Fernandez,
Dolores Planelles,
Affiliation Laboratory of Histocompatibility-Molecular Biology, Centre for Blood Transfusion, Valencia, Spain
Gregorio Carretero,
Affiliation Dermatology Department, Doctor Negrín Hospital, Las Palmas de Gran Canaria, Spain
Ana Lluch,
Eduardo Nagore,
Affiliation Dermatology Department, Instituto Valenciano de Oncología, Valencia, Spain
Gloria Ribas
* E-mail: gribasdespuig@gmail.com
Maria Peña-Chilet Maider Ibarrola-Villava ... Gloria Ribas
<% if(figureList.length > 1) { %>
All Figures Next Previous
Show in Context
Solar radiation should be avoided in melanoma patients. Nevertheless, this is the main means by which the body produces vitamin D. Evidence suggests a protective role against cancer for vitamin D. Since vitamin D performs its function by binding the receptor encoded by the vitamin D-receptor gene (VDR), most studies have focused on polymorphisms (SNPs) within this gene. However, the gene encoding the vitamin D-binding protein (GC) appears in recent studies as a major player in the role of a serum vitamin D level regulator and in Cutaneous Melanoma (CM) predisposition.
We performed a case-control study of 12 polymorphisms on GC and 9 on VDR among 530 cases and 314 controls from Spanish population.
We found association between SNP rs12512631, located 3′downstream of GC, and risk of CM that seems to fit a dominant model (OR 1.63 95%CI 1.23–2.17 p-value 7×10−4). This association remained Bonferroni's correction and after adjustment for potential confounders (p-value 3×10−3) and even after increasing the sample size to 1729 individuals (p-value 0.0129). Moreover, we confirmed evidence of an association between CM susceptibility and the linkage disequilibrium block marked by tag-SNP rs222016 (p-value 0.032). This block covers the GC intron 1 region, with probable regulatory functions.
To our knowledge, this is the first vitamin D pathway-related polymorphism study in melanoma risk conducted in the Spanish population. Furthermore, we show an association between polymorphisms in GC and melanoma risk, confirming recent studies in different populations.
Citation: Peña-Chilet M, Ibarrola-Villava M, Martin-González M, Feito M, Gomez-Fernandez C, Planelles D, et al. (2013) rs12512631 on the Group Specific Complement (Vitamin D-Binding Protein GC) Implicated in Melanoma Susceptibility. PLoS ONE 8(3): e59607. https://doi.org/10.1371/journal.pone.0059607
Editor: Nathan A. Ellis, University of Illinois at Chicago, United States of America
Received: November 19, 2012; Accepted: February 15, 2013; Published: March 27, 2013
Copyright: © 2013 Peña-Chilet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This study has been supported by a grant from the National Health System Ministry (Institute Carlos III) PI10_0405. MPC is funded by the Generalitat Valenciana Conselleria d'Educació VALi+d program (ACIF/2011/207). MIV is funded by the Spanish Ministry of Science and Education under a FPI grant (BES-2008-009234). GR is funded by the Spanish Ministry of Health (CP08_00069). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Cutaneous Melanoma (CM) is caused by the malignant transformation of melanocytes, pigment producer cells, located within epidermal basal cells. These cells produce melanin as a response to UV radiation. Melanoma incidence has been increasing at higher rates than any other malignant tumour in recent decades, and it causes the greatest number of skin-cancer-related deaths worldwide [1]. The main reason for the recent rise in CM incidence is attributed mainly to increased intermittent exposure to UV radiation.
The data about whether sun exposure in Caucasian populations results in health risks or benefits is controversial. Solar radiation is the main source of vitamin D synthesis in humans; however, uncontrolled and intensive sun exposure is dangerous to health and contributes to the development of melanoma [2], [3]. Given that occupational sun exposure has been reported to protect against melanoma, that solar radiation is the main means by which the body produces vitamin D, and that vitamin D is reported to have anti-proliferative effects in melanoma cells, interest has arisen over a possible role for vitamin D in melanoma prevention [4].
The most studied gene in the vitamin D pathway is the vitamin D receptor gene (VDR) located on chromosome 12. The gene has 11 exons and encodes the receptor of the calcitriol form of vitamin D. This receptor is a nuclear transcription and regulating factor that belongs to the steroid hormone superfamily of receptors. Nuclear receptors integrate hormonal, dietary, and other extracellular signals into cell fate decisions via regulation of gene expression and repression of a host of common gene targets. Moreover, many studies have addressed the polymorphisms of the vitamin D receptor in several cancers including ovarian carcinoma [5], breast cancer [6], colorectal cancer [7], non-Hodgkin lymphoma [8], renal cancer [9], oral squamous cell carcinoma [10], esophageal adenocarcinoma [11], non-small cell lung cancer [12], prostate cancer [13], and melanoma [14], [15].
Most recently, genome-wide association studies (GWAS) reported that a SNP in the GC gene is associated with serum levels. This gene encodes for the group-specific component or VDBP (vitamin D-binding protein), with the additional probable involvement of genes related to the production of the active form of vitamin D [16]. VDBP belongs to the albumin family, together with human serum albumin and alpha-fetoprotein. Located on chromosome 4q11–q13, the GC gene is 42.5 kb long and contains 13 exons. At least six non-synonymous SNPs are described, two of them with common frequency (rs7041 and rs4588). The VDBP greatly facilitates vitamin D actions by carrying vitamin D metabolites to various sites of action, while polymorphic VDBP proteins differ in their affinity for 1,25(OH)2 D metabolite [17]. VDBP has been related to multiple sclerosis [18], its association with various lung diseases including asthma, chronic obstructive pulmonary disease and tuberculosis has also been studied [19]. Recent studies, including GWAS, have shown that allelic variation in the GC gene is associated with both VDBP and serum 25(OH)D concentrations, as well as a higher affinity of the VDBP to vitamin D metabolites [16], [20].
Despite the large number of studies evaluating the association between VDR variants and CM, the conclusions on its role in the aetiology are still indecisive. The association between GC variants and vitamin D levels in plasma has already been tested and proved [16], [20], but only one study supports the association between polymorphisms on GC and CM [21]. In the present study, we show a comprehensive analysis of VDR and GC association with CM using data from a wide case-control study (530 melanoma cases and 314 controls) in a Spanish population. Data from VDR have been enlarged in sample size and density of SNPs from previous results [22]. We consider that the present study increases our knowledge of the relationship between vitamin D levels and CM predisposition in a Southern European country such as Spain, where sun incidence is higher than in northern European countries.
All participants gave written informed consent for this study. The study was approved by the Ethics Committee of Gregorio Marañón University General Hospital.
Study Subjects and Data Collection
A total of 530 sporadic CM patients were recruited from 1st September 2004 to the present, at the departments of Dermatology of three different hospitals in Madrid: Gregorio Marañón University General Hospital, La Paz University Hospital and Ramón y Cajal University Hospital. A total of 314 volunteer cancer-free control samples, frequency matched to cases by sex and age in ten-year categories, were recruited from the Madrid College of Lawyers, the National Cancer Research Centre (CNIO) and from the Gregorio Marañón University General Hospital (Table 1). All participants were non-related Caucasians of Spanish origin, with the same ethnic background [23].
PowerPoint slide
Table 1. Sample distribution.
https://doi.org/10.1371/journal.pone.0059607.t001
A standardized questionnaire was used to collect information on pigmentation characteristics such as eye, hair and skin colour, number of naevi, presence of lentigines, sun exposure habits, and personal and family history of melanoma, cancer or any other skin disease. Each individual questionnaire has been guided by an expert clinician or a trained nurse. For cases only, tumour characteristics were added and medical data were obtained via medical exploration, those patients with acral or multiple melanoma were excluded from the study, as well as control individuals with suspected personal or family history of melanoma. We selected the following variables: age at diagnosis, sex, eye colour categorized as blue, grey and light green (light eye colour), hazel, light brown, brown and black (dark eye colour), hair was grouped as light colour (very light blonde and red-haired) and dark colour (light brown, medium brown and black) the skin colour stratification was made by the clinicians implicated in the project as very light and never tans, light, medium and dark, however to compare between cases and controls we only show two main categories, fair skin color (very light and never tans and light) and dark skin color (medium and dark), number of naevi (less than 25, between 25–50, between 50 and 100 and more than 100), presence of solar lentigines (yes, no and only on shoulders) and childhood sunburn events (categorization of these variables as well as the distribution of the Spanish population sampled are shown in Table 2).
Table 2. Classification of the Spanish samples studied by age, sex and phenotype.
We used an additional pool of samples to enlarge the sample size. Samples were obtained from 334 CM patients and 158 control individuals from the Valencian Institute of Oncology (IVO) and 171 cases and 212 controls from Dr Negrín Hospital, Las Palmas de Gran Canaria. A total set of 515 cases and 370 control individuals (Table 1).
Genomic DNA from cases and controls was isolated from peripheral blood lymphocytes and diluted to a final solution of 50 ng/µl using the traditional saline method or the DNAzol procedure (Invitrogen, Eugene, OR, USA). DNA concentration was quantified in samples using Quant-iT PicoGreen dsDNA Reagent (Invitrogen, Eugene, OR, USA). Further concentration measures were obtained using a Nanodrop 2000 spectrophotometer. Genomic DNA was amplified using the GenomiPhi DNA Amplification Kit (GE Healthcare Bio-Sciences AB, Uppsala, Sweden).
SNP Selection
We selected tag-SNPs from vitamin D metabolism-related genes, GC and VDR. These SNPs were chosen using either previous literature information or the HapMap International Project [24] by means of the HaploView v4.2 software forcing Tag-SNPs from the European_CEU subset of data. We selected marker SNPs with a minor allele frequency (MAF) higher than 0.05, with a Hardy-Weinberg equilibrium p-value cutoff of 0.001, we have set an r2 threshold of 0.8. Four linkage disequilibrium (LD) blocks were obtained using HapMap_CEU data for GC and seven blocks for VDR. A total of 21 SNPs were included (12 SNPs belonging to GC and 9 to VDR). Public databases were used to collect additional information about SNPs and genes: NCBI http://www.ncbi.nlm.nih.gov and Ensembl http://www.ensembl.org. Details such as MIM code, location, encoded protein, context sequence, nucleotide changes, MAF for HapMap_CEU and HapMap_TSI (based on a sample population from Northern Europe and Tuscany Italy respectively) and calculated MAF for both cases and controls of all the SNPs studied are provided in Table S1 and in Table 3.
Table 3. Allelic frequencies in cases and controls in spanish population for the GC gene SNPs studied.
Genotyping Assays
Genotyping was carried out using Kaspar technology (KBiosciences, Hoddesdon, UK). The PCR was performed in a reaction volume of 4 µl containing about 10 ng of genomic DNA, a final concentration of 4× New Kaspar Reaction Mix, and 12 µM of each Kaspar primer.
The PCR assays were performed according to the manufacturer's instructions. The genotype of each sample was determined by measuring final allele-specific fluorescence in the ABI Prism 7900 HT Detection System, using the SDS 2.3 software for allelic discrimination (Applied Biosystems, Foster City, USA).
As a quality control measure, we included one non-template sample and one sample duplicate per 96-well plate (a total of four per 384-well plate used). Genotypes were provided automatically by the software and were confirmed manually by two different laboratory personnel.
Analyses were performed using SPSS v17 (SPSS, Chicago, IL, USA). All p-values were two-sided, and those less than 0.05 were considered statistically significant. We analysed the haplotypes using Haploview v4.2 software, we obtained χ2 values by performing a linkage case-control test as described previously [25]. Bonferroni's correction was used as the method of adjustment for multiple comparisons. For all polymorphisms studied, Fisher's exact test was used both to test for deviations from HWE among controls, and to compare differences in the MAF distributions between cases and controls. We rejected HWE when p-values were lower than 0.0024 according to Bonferroni's correction for 21 comparisons. In order to assess associations between genotypes, haplotypes and CM risk and between SNPs and each phenotypic characteristic, several analyses were performed. Genotype-related odds ratios (ORs), their corresponding 95% confidence intervals (CIs) and associated p-values were estimated via unconditional logistic regression. This was done for each model: genotypic, dominant and recessive. Same analyses were conducted between SNPs and each phenotypic characteristic. The power of the significant results was obtained using POWER v3.0 software (available at http://dceg.cancer.gov/tools/design/power), with the sample size of this study we are able to obtain a power of 80% as from OR value of 1.49. Odds ratios were then adjusted for known and suspected melanoma risk factors (eye, hair and skin colour, number of naevi, lentigines, and childhood sunburns) in order to assess the potential confounding effects by multivariate logistic regression We use as potential confounders all phenotypic traits that show differences between cases and controls (Table 2), however we added number of naevi and skin color in this study because both are well recognized risk factor for melanoma predisposition [26], [27].
For the second set of samples we obtained genotype-related ORs for genotypic, dominant and recessive models, their corresponding 95% CIs and associated p-values taking into account only SNPs that gave interesting results. These statistics were estimated using unconditional logistic regression.
To study the functional implications of SNPs, we used the Pupasuite3.1 software available online at http://pupasuite.bioinfo.cipf.es. We analysed all SNPs on the GC gene with a minor allele frequency higher than 0.05 provided by HapMap (a total of 40 SNPs, provided upon request). We searched for all non-synonymous SNPs, candidate transcription factor (TF) binding sites (through TRANSFAC, JASPAR and ORegAnno), low-flexibility promoter regions with a minimum length of 10 bp, highly conserved regions, splice sites created or disrupted by SNPs, and the presence of miRNA targets. Search criteria were provided at the aforementioned website.
Allelic Distribution of Polymorphisms and Association with CM Risk
After applying Bonferroni's correction, one SNP on VDR was out of HWE, rs4237855 (p-value 1.09×10−12), and was removed from further analyses. The remaining SNPs complied with HWE. We confirmed that our control population has allele frequencies similar to the HapMap_CEU or HapMap_TSI ones.
Based on unadjusted p-values, we observed evidence of differences between cases and controls in MAF for SNP rs12512631 on the GC gene (p-value 0.0196) which codes for the vitamin D transporter protein. We did not observe differences in the MAF for any other SNP. (Table 3).
Allele frequencies for SNPs (on HapMap_CEU, HapMap_TSI and genotyped cases and controls), p-values for their comparison between 530 CM cases and 314 control individuals, along with p-values for the test of departure from HWE among controls are detailed in Table 3.
Association between Genotypes and Melanoma Risk
The implication of these vitamin D-related genes in melanoma was investigated further by comparing the genotypic distributions of all the SNPs studied. The estimated ORs and associated p-values are shown in Table 4. This was also done for dominant and for recessive models. Relevant results as well as the values adjusted by phenotypic characteristics are shown in Table 5.
Table 4. Genotypic distribution among cases and controls in a Spanish population.
Table 5. Genotypic analyses of SNPs with Cutaneous Melanoma risk association.
One SNP was found to be associated with CM susceptibility risk, rs12512631 on the GC gene (OR 1.29 95%CI: 1.04–1.60; p-value 0.0190) (Table 4). Moreover, the association between rs12512631 and CM risk was highly significant in the dominant model (OR 1.63 95% CI: 1.23–2.17; p-value 7×10−4) (Table 5). This significance remained after Bonferroni's correction for multiple testing.
A trend to significance was found for rs222016 (OR 1.23 95% CI: 0.83–1.82; p-value 0.102). Furthermore, when performing the statistical analyses considering dominant model, we obtained borderline significance (OR 1.37, 95% CI: 0.98–1.93; p-value 0.068). No association remained statistically significant for any other SNP.
To assess the independence of risk factors associated with CM, we performed a multivariate analysis that took into account phenotypic risk factors such as eye, skin and hair colour, number of naevi, lentigines and childhood sunburn events, along with candidate SNPs. The associated SNP, rs12512631, maintained its significance for both genotypic (p-value 0.041) and dominant models (p-value 0.003), whereas there was no further trend to significance for rs222016 (see adjusted values in Table 5).
We increased the population sample and performed the association analyses for the two significant CM-associated SNPs (rs12512631 and rs222016). We studied a total of 1045 melanoma patients and 684 control individuals, and the statistical significance of rs12512631 remained (OR 1.28 95% CI: 1.05–1.56, p-value 0.013). This association continued to be significant after Bonferroni's correction for two comparisons (p-value threshold of 0.025) (Table 5).
Associations between Genotypes and Phenotypic Characteristics
We assessed whether SNPs from the GC and VDR genes were associated with various phenotypic characteristics. The SNP rs3733359, located on the 5′UTR of the GC gene, showed a significant association with dark skin colour (OR 0.53, 95% CI: 0.30–0.94, p-value 0.023). We also observed a weak significant association for the 3′UTR SNP rs739837 of the VDR gene with fair skin colour (p-value 0.048). We found strong association between non-synonymous SNP rs2228570, located within exon 4 of the VDR gene, and absence of childhood sunburn (OR 0.065 95% CI 0.49–0.86, p-value 0.003). No more evidence of associations was found.
Haplotype Analysis and Association with Melanoma Risk
We performed haplotype analyses using the 11 tag-SNPs in GC (the gene on which we found an associated SNP) selected previously from HapMap data. These SNPs were organized into five independent blocks according to the Haploview program for the use of data from a European subset of samples (HapMap_CEU). Block 1 included rs12512631 in a 3′downstream region of GC. Block 2 is represented by one SNP located 3′downstream and three SNPs within the 3′end of the gene, two of them corresponding to exon 9. Blocks 3, 4 and 5 contained six SNPs from various intron regions, including intron 1, and SNP with rs3733359, located on 5′UTR. Block 5 represented the most likely promoter region with consensus sequences for TF binding sites. Data analysis was done according to the block structures detailed in Figure 1. The case-control analysis of the haplotype distribution revealed a statistical association with melanoma susceptibility on two SNPs, rs12512631 (p-value 9×10−3), and rs222016 (p-value 0.031), representing Blocks 1 and 3, respectively (Table S2). These data were coherent with the associations described above.
Figure 1. Haplotype distribution within GC gene according to Tag-SNPs selected by Haploview v4.2.
Genotyped SNPs are indicated by their rs#. LD Blocks are shown in gray. GC gene chromosomic location and ideogram in reverse orientation appears on the top of the figure, where boxes represent exons and horizontal black lines introns. Bold denotes associated risk alleles, and light grey lines indicate connected haplotypes.
https://doi.org/10.1371/journal.pone.0059607.g001
Functional Implication
To assess for possible functional implications of polymorphisms, we carried out a prioritization of SNPs based on functional properties using the Pupasuite 3.1 software. Results showed non-synonymous changes of aminoacid on rs4588 (K436T) and rs7041 (E416D). TRANSFAC revealed three SNPs located in consensus sequence affecting the TF binding sites; rs4588 FOXJ2, rs7041 HNF-1 and rs222014 E2F-1 (located within intron 3 and grouped on block 3 with tag-SNP rs222016). None of the other SNPs seemed to have any additional functionality.
In this case-control study, we have detected for the first time statistical evidence suggesting that rs12512631 on GC is associated with risk for CM. GC is an essential gene in the vitamin D pathway since it codifies for VDBP, the transporter of all the intermediate and final forms of vitamin D. Variants in this gene may modulate protein expression or activity of this protein and, therefore may affect vitamin D synthesis and distribution. There are few studies of GC polymorphisms, however, to our knowledge all of them are related to the serum vitamin D levels in diseases such as CM, prostate and colorectal cancer. In these, a clear association was found between GC polymorphisms and circulating vitamin D levels, but the association between polymorphisms and the disease itself was not at all clear [21], [28], [29], [30]. Shen et al. reported that one allele of the GC gene may be a risk factor for chronic obstructive pulmonary disease [31], and Abbas et al. observed a lower breast cancer risk associated with the Gc2–2 allele, independent of vitamin D levels [32]. Recently an independent GWAS on vitamin D levels, with further validation on CM patients, has pointed again to the GC gene as a candidate for melanoma susceptibility when vitamin D levels are taken into consideration [16], [21].
Our study suggests that the 3′downstream region of the GC gene, marked through the SNP rs12512631, is associated with CM risk. Furthermore, evidence of association was suggested by the tag-SNP rs222016, which marks a large disequilibrium block within the gene, including intron 1. SNP rs222016 is in LD with SNP rs222014, which could have functional implications through the disruption of a transcription factor element (E2F-1), but we cannot discard other mechanisms such as alternative splicing signalling. Previous studies have shown an association between tag-SNP rs12512631 and susceptibility to prostate and colorectal cancer, which supports our results [28], [29].
We did not observe any evidence of association between CM and VDR variants overall, in accordance with our previous results [22]. Some other controversial results are reported in the literature. A review by Köstner indicates only one variant in VDR associated with CM risk, Fok1 (rs2228570) [33], but a meta-analysis of various studies revealed that the only variant that presents solid evidence is Bsm1 (not considered in our study) and remarked on the need to adjust by phenotype or environmental characteristics [34]. Gapska et al. found an association only when analyzing the haplotypes, but not the variants themselves [14]. More recent studies have not detected an association with CM risk on the VDR variants unless adjusting by vitamin D levels [15], [35], [36]. This last situation might explain why we have not found a significant association; vitamin D levels were not taken into account.
The strength of this study is the homogeneity of the Spanish population sample and the ability to control for established risk factors for CM through a structured questionnaire. We recognize, however, some potential for misclassification of phenotypic characteristics due to the subjective nature of the phenotypic attributes considered. Controls participated on a volunteer basis, which may have introduced some selection bias.
We show a comprehensive study of genetic variation on the vitamin D pathway genes VDR (vitamin D receptor) and GC (vitamin D transporter), and examine their putative role in CM susceptibility. We observed statistically significant results for CM susceptibility with two variants in the GC gene, but none in the VDR gene. One of these associations remained significant after correction for multiple testing, SNP rs12512631. This association suggests that GC may also play a role in modulating the susceptibility to CM.
We encourage replication of these findings in independent studies since the GC gene may well be a new marker for CM predisposition.
Table S1.
SNPs on GC and VDR genes considered in this study. GC refers to Vitamin D binding protein gene; VDR refers to Vitamin D receptor gene. Bold in sequence context denotes nucleotide change. Location is described considering as the first Exon 1 of consensus sequence. DWST means downstream, UTR means untranscribed region and UPST means upstream.
https://doi.org/10.1371/journal.pone.0059607.s001
(DOCX)
Case-control study based on haplotypes in the GC gene conducted in Spanish population. Bold denotes statistically significant results. Italic Haplotypes on each block mark the risk haplotype. The Marker number indicates the order of the tag-SNP on the gene. LD Block means linkage disequilibrium block. Frequencies are calculated for the association alleles of each haplotype among 530 cases and 314 controls.
We would like to give thank to all the patients and volunteers who gave their consent for the study. We also thank the medical staff of Gregorio Marañón, La Paz and Ramón y Cajal Hospitals for collecting the samples and the Biobank of the Instituto Valenciano de Oncología for providing the material for the genetic analysis. Genotyping with Kaspar was performed at the Unidad Central de Investigación Médica of the Facultad de Medicina of the University of Valencia.
Conceived and designed the experiments: MPC MIV AL EN GR. Performed the experiments: MPC MIV GR. Analyzed the data: MPC MIV GR. Contributed reagents/materials/analysis tools: MMG MF CGF DP GC AL EN. Wrote the paper: MPC MIV EN GR.
1. Jerant AF, Johnson JT, Sheridan CD, Caffrey TJ (2000) Early detection and treatment of skin cancer. Am Fam Physician 62: 357–368, 375–356, 381–352.
2. Holick MF (2003) Vitamin D deficiency: what a pain it is. Mayo Clin Proc 78: 1457–1459.
3. Holick MF (2003) Evolution and function of vitamin D. Recent Results Cancer Res. 164: 3–28.
4. Field S, Newton-Bishop JA (2011) Melanoma and vitamin D. Mol Oncol. 5: 197–214.
5. Lurie G, Wilkens LR, Thompson PJ, Carney ME, Palmieri RT, et al. (2011) Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: pooled analysis in five studies within the Ovarian Cancer Association Consortium. Int J Cancer 128: 936–943.
6. Alimirah F, Peng X, Murillo G, Mehta RG (2011) Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells. PLoS One 6: e16024.
7. Touvier M, Chan DS, Lau R, Aune D, Vieira R, et al. (2011) Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 20: 1003–1016.
8. Smedby KE, Eloranta S, Duvefelt K, Melbye M, Humphreys K, et al. (2011) Vitamin D receptor genotypes, ultraviolet radiation exposure, and risk of non-Hodgkin lymphoma. Am J Epidemiol 173: 48–54.
9. Karami S, Brennan P, Navratilova M, Mates D, Zaridze D, et al. (2010) Vitamin d pathway genes, diet, and risk of renal cell carcinoma. Int J Endocrinol 2010: 879362.
10. Bektas-Kayhan K, Unur M, Yaylim-Eraltan I, Ergen HA, Toptas B, et al. (2010) Association of vitamin D receptor Taq I polymorphism and susceptibility to oral squamous cell carcinoma. In Vivo 24: 755–759.
11. Chang CK, Mulholland HG, Cantwell MM, Anderson LA, Johnston BT, et al.. (2011) Vitamin D Receptor Gene Variants and Esophageal Adenocarcinoma Risk: A Population-Based Case-Control Study. J Gastrointest Cancer.
12. Srinivasan M, Parwani AV, Hershberger PA, Lenzner DE, Weissfeld JL (2010) Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer. J Steroid Biochem Mol Biol 123: 30–36.
13. Kidd LC, Paltoo DN, Wang S, Chen W, Akereyeni F, et al. (2005) Sequence variation within the 5' regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk. Prostate 64: 272–282.
14. Gapska P, Scott RJ, Serrano-Fernandez P, Mirecka A, Rassoud I, et al. (2009) Vitamin D receptor variants and the malignant melanoma risk: a population-based study. Cancer Epidemiol 33: 103–107.
15. Orlow I, Roy P, Reiner AS, Yoo S, Patel H, et al.. (2011) Vitamin D receptor polymorphisms in patients with cutaneous melanoma. Int J Cancer.
16. Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, et al. (2010) Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 19: 2739–2745.
17. Pani MA, Regulla K, Segni M, Hofmann S, Hufner M, et al. (2002) A polymorphism within the vitamin D-binding protein gene is associated with Graves' disease but not with Hashimoto's thyroiditis. J Clin Endocrinol Metab 87: 2564–2567.
18. Disanto G, Ramagopalan SV, Para AE, Handunnetthi L (2010) The emerging role of vitamin D binding protein in multiple sclerosis. J Neurol 258: 353–358.
19. Chishimba L, Thickett DR, Stockley RA, Wood AM (2010) The vitamin D axis in the lung: a key role for vitamin D-binding protein. Thorax 65: 456–462.
20. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, et al. (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376: 180–188.
21. Davies JR, Chang YM, Snowden H, Chan M, Leake S, et al. (2011) The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate. Cancer Causes Control 22: 1471–1482.
22. Barroso E, Fernandez LP, Milne RL, Pita G, Sendagorta E, et al. (2008) Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies. BMC Cancer 8: 385.
23. Laayouni H, Calafell F, Bertranpetit J (2010) A genome-wide survey does not show the genetic distinctiveness of Basques. Hum Genet 127: 455–458.
24. The International HapMap Project. Nature 426: 789–796.
25. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263–265.
26. Newton Bishop JA, Bishop DT (2005) The genetics of susceptibility to cutaneous melanoma. Drugs Today (Barc) 41: 193–203.
27. Kvaskoff M, Whiteman DC, Zhao ZZ, Montgomery GW, Martin NG, et al. Polymorphisms in nevus-associated genes MTAP, PLA2G6, and IRF4 and the risk of invasive cutaneous melanoma. Twin Res Hum Genet 14: 422–432.
28. Ahn J, Albanes D, Berndt SI, Peters U, Chatterjee N, et al. (2009) Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis 30: 769–776.
29. Poynter JN, Jacobs ET, Figueiredo JC, Lee WH, Conti DV, et al. (2010) Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 19: 525–536.
30. Hibler EA, Hu C, Jurutka PW, Martinez ME, Jacobs ET (2012) Polymorphic Variation in the GC and CASR Genes and Associations with Vitamin D Metabolite Concentration and Metachronous Colorectal Neoplasia. Cancer Epidemiol Biomarkers Prev 21: 368–375.
31. Shen LH, Zhang XM, Su DJ, Yao SP, Yu BQ, et al. (2010) Association of vitamin D binding protein variants with susceptibility to chronic obstructive pulmonary disease. J Int Med Res 38: 1093–1098.
32. Abbas S, Linseisen J, Slanger T, Kropp S, Mutschelknauss EJ, et al. (2008) The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status. Cancer Epidemiol Biomarkers Prev 17: 1339–1343.
33. Kostner K, Denzer N, Muller CS, Klein R, Tilgen W, et al. (2009) The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res 29: 3511–3536.
34. Mocellin S, Nitti D (2008) Vitamin D receptor polymorphisms and the risk of cutaneous melanoma: a systematic review and meta-analysis. Cancer 113: 2398–2407.
35. Newton-Bishop JA, Beswick S, Randerson-Moor J, Chang YM, Affleck P, et al. (2009) Serum 25-hydroxyvitamin D3 levels are associated with breslow thickness at presentation and survival from melanoma. J Clin Oncol 27: 5439–5444.
36. Randerson-Moor JA, Taylor JC, Elliott F, Chang YM, Beswick S, et al. (2009) Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data. Eur J Cancer 45: 3271–3281.
Is the Subject Area "Vitamin D" applicable to this article?
Is the Subject Area "Melanomas" applicable to this article?
Is the Subject Area "Haplotypes" applicable to this article?
Variant genotypes
Is the Subject Area "Variant genotypes" applicable to this article?
Is the Subject Area "Molecular genetics" applicable to this article?
Overexposure to sun
Is the Subject Area "Overexposure to sun" applicable to this article?
Is the Subject Area "Eye color" applicable to this article?
Is the Subject Area "Introns" applicable to this article?


text:
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN"
  "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">

    <meta http-equiv="Content-Type" content="text/html; charset=utf-8" />

    <title>Reporting and statistics — Varnish version 4.0.2 documentation</title>

    <link rel="stylesheet" href="../_static/default.css" type="text/css" />
    <link rel="stylesheet" href="../_static/pygments.css" type="text/css" />

    <link rel="top" title="Varnish version 4.0.2 documentation" href="../index.html" />
    <link rel="up" title="The Varnish Users Guide" href="index.html" />
    <link rel="next" title="Logging in Varnish" href="operation-logging.html" />
    <link rel="prev" title="Device detection" href="devicedetection.html" />

ナビゲーション

          索引

          次へ |

          前へ |

Varnish version 4.0.2 documentation »

The Varnish Users Guide »

Reporting and statistics¶

This section covers how to find out what Varnish is doing, from
the detailed per HTTP request blow-by-blow logrecords to the global
summary statistics counters.

Logging in Varnish

Statistics

varnishtop

varnishhist

varnishstat

前のトピックへ

Device detection

次のトピックへ

Logging in Varnish

このページ

ソースコードを表示

クイック検索

    <form class="search" action="../search.html" method="get">
      <input type="text" name="q" />
      <input type="submit" value="検索" />
      <input type="hidden" name="check_keywords" value="yes" />
      <input type="hidden" name="area" value="default" />
    </form>

    モジュール、クラス、または関数名を入力してください

ナビゲーション

          索引

          次へ |

          前へ |

Varnish version 4.0.2 documentation »

The Varnish Users Guide »

        © Copyright 2010-2014, Varnish Software AS.
      このドキュメントは Sphinx 1.2.3 で生成しました。


Cars were either stuck or buried in snow across Binghamton, New York.
BINGHAMTON, N.Y. -- Much of the Northeast woke up Wednesday beneath a thick blanket of snow.
The totals may have underwhelmed in the big cities near the coast-- but not to the west. Some 20.3 inches fell in Vernon, New Jersey, 26.2 in Mount Pocono, Pennsylvania, and 22 in Syracuse, New York.
But they got more than that in Binghamton, N.Y. Cars were either stuck or buried in snow across the city.
New York Governor Andrew Cuomo said the Binghamton area was one of the hardest hit by Tuesday's nor'easter. Cuomo went to Binghamton on Wednesday and said he was sending over 100 plows and 100 members of the National Guard as people started to dig out.
With snow still falling in Binghamton, emergency crews toiled around the clock to dig out from a blizzard that dumped nearly three feet of snow.
Dozens of drivers were stranded -- even a plowtruck, and the National Guard was activated.
The storm that blanketed central New York largely missed most major cities across the Northeast. Predictions of up to 16-20 inches of snow did not pan out, leading to provocative headlines.
In Binghamton, postmaster Lorna Millers' crew did not deliver mail yesterday -- for the first time in 25 years. Service resumed Wednesday, even though the delivery trucks had to be dug out.
Across the city, at least 50 percent of the 100,000 mailboxes are buried in snow. The area is about to hit an all-time seasonal snowfall record. For the season, it's about to hit 128 inches.


text:
ExploreAustraliaVictoriaMelbourneHow Melbourne Got So Melbourne – An Investigation
How Melbourne Got So Melbourne – An Investigation
By Larissa Dubecki - Writer
How does a city obsessed with an oval ball have enough passion left over for cool design and a cranking food culture? We hit the streets and gets between the layers of Melbourne's urban soul.
There's a story told about Flinders Street Station, the grandly decaying landmark – designed around the time of Federation – at the cultural axis of Melbourne. The rumour goes that the architectural plans shipped from London were somehow mixed up with blueprints intended for Bombay – which is how Melbourne wound up with an ornate, grandiose and sprawling central station with a vaguely "days of the Raj" feel.
It's a great tale, though sadly apocryphal (the other great station legend – that there's an underground bowling alley and its closed-off upper levels contain a ballroom – is wonderfully true). However, it shows that Melbourne's design obsession, rather than being new, has been endemic for well over a century.
Like all great cities, Melbourne is a palimpsest – a series of layers, the past discerned in shadowy outline beneath the present. It certainly isn't a box-ticking destination. Sure, the first-time visitor can see the Shrine of Remembrance and the contradictorily named National Gallery of Victoria then swing by bright and shiny Federation Square or the UNESCO World Heritage-listed Royal Exhibition Building. Only a hack could fail to make Brighton Beach's colourful bathing boxes look pretty on Instagram. But the truth is that while some cities reveal themselves to you instantly, others need coaxing.
If Melbourne's old charms have been somewhat buried – Ava Gardner was once famously misquoted calling it "the perfect place to make a film about the end of the world" and the sobriquet stuck – the past 20 years have seen a renaissance of underground art, design, food and culture that has propelled the city overground.
Visit the top end of Bourke Street, the bustling European core of the city where footpath tables spill over with diners eating calamari fritti and bistecca, and imagine the weekend ghost town of 20 years ago.
"I can remember kicking a footy in the middle of the road on a Sunday afternoon," says Jerome Borazio, who revved up Melbourne's cultural capital in 2004 with the simple yet revolutionary act of opening a tiny bar in a gritty laneway behind the Myer department store, using milk crates for seats.
The milk crate is emblematic of the analogue pleasures of the Melbourne brand (the ground zero of yarn bombing, natural home of the fixie bicycle, scene of the Brylcreem quiff revival that is the London Barber Movement); it's a design motif borrowed by endless cafés and bars – much to Borazio's bemusement. "My attitude was: it's a bar and you should be standing up but if you want to sit down, have a milk crate." St Jerome's bar was lost to the development of the Emporium shopping centre but its left-of-centre legacy lives on at St Jerome's – The Hotel, which offers luxury camping in the CBD on the AstroTurf roof of Melbourne Central shopping centre.
"Melbourne has an amazing, unique style that's different to every other Australian capital city," says Borazio, who has spent the past 12 months scouting the nation for the location of his second hotel. "Having traversed the country, where do you think we wound up? Melbourne."
His empire flourishes in the city's quirkier spots – none more so than Ponyfish Island, a floating bar in the middle of the Yarra River that's accessed via the pedestrian bridge connecting Southbank to Flinders Street Station.
The river precinct is rich with historical reclamation. To the east of Ponyfish is the outdoor Arbory Bar & Eatery running along Flinders Street Station's former Sandridge railway line. Further north, Riverland bar inhabits Federation Wharf's once-decrepit bluestone vaults. This previously Dickensian stretch of the Yarra has transformed in a few short years from a no-go zone into a must-do.
None of these fortuitous meetings of history and hopes can be accessed by car, which introduces another point essential to the enjoyment of Melbourne. It's a city best explored on foot, thanks to a serpentine network of laneways and arcades that can feel like an urban sophisticate's version of Snakes and Ladders. It's the only way to discover the Art Deco, stained-glass wonder of the Cathedral Arcade on Swanston Street, with its edgy local fashion boutiques. Or the echoing and mysterious Nicholas Building directly above it – a vertical village connected by a juddering elevator where ateliers, studios and galleries form a thriving creative hub. Among other activities, life-drawing classes are held there three evenings a week.
The visitor might note that Melbourne is a contrary beast. The term "world-class" is bandied around with wearying regularity but as a lived-in city it's all about small scale and boutique. It's a place in thrall to homegrown quirk, summed up as the twin peaks of fashion – the dark and directional Alpha60 label (alpha60.com.au) is the de facto uniform of the creative class – and a booming food, coffee and bar scene based on a fiercely fought competition to find the most outlandish real estate. Hence the improbably small Switchboard café (220 Collins Street, Melbourne; 03 9619 1111), housed in a former switchboard room and window display in the historic Manchester Unity Building; and newcomer Whitehart Bar, which wins the Melbourne design-trope trifecta by colonising a former car park in a dead-end laneway using shipping containers – the architectural answer to the milk crate.
They're not always easy to find – which is exactly the point, says Miss Pearls (aka Paula Scholes), hostess at one of the city's original rooftop bars, Madame Brussels on Bourke Street. It's designed like an English garden-party fantasia, complete with waiters clad in tennis outfits. "It's all about feeling rewarded when you find the small doorway, the hidden laneway… Melbourne really makes you work for it."
SEE ALSO: An A-Z Guide to Melbourne's Best Laneways, Alleys and Arcades
The practice of perambulation will inevitably reveal Melbourne's strong suit in street art, a subject with which the city has an uneasy relationship. Only recently the council ordered the removal of a work by lauded artist Vincent Fantauzzo, while a piece from shadowy UK-based artist Banksy famously fell victim to an overzealous cleaner. Hosier Lane is the flashpoint of the street-art scene. Look back towards Flinders Street for the money shot: the honeycomb steel and glass of Federation Square's The Atrium, sandwiched between stern 19th-century walls. ACDC Lane and Duckboard Place are among other tributaries also affording aerosol riches.
Street artist Kaff-eine swapped her career as a public servant for art several years ago and hasn't looked back. Look out for her trademark whimsical figure high up on Rutledge Lane. Her own favourite piece is by German duo Herakut, in Fitzroy North, opposite the Edinburgh Gardens on Brunswick Street: a fey, two-storey image of a girl riding a monkey – "It's beautiful, poignant, powerful street art" – that provides an arresting backdrop to the full-throated support of grassroots football on the Fitzroy Reds' home ground each winter weekend.
Even art of a more codified kind embraces the city's love of the unique. In the well-heeled, leafy suburb of Kew, the Lyon Housemuseum is an appointment-only gallery where one of the largest private collections of contemporary Australian art is displayed in the home of architect and owner Corbett Lyon. Once you've digested the thrill of works by the likes of Howard Arkley, Polly Borland and Callum Morton, you'll appreciate Lyon's clever ploy to dissociate art from the traditional gallery.
On that note, you might also want to visit Morton's red scaffolding-like installation boldly framing the doorway of St Kilda's Bar Di Stasio, a wickedly inveigling kind of place where people pop in for a quick drink, only to emerge five hours later. Bon vivant owner Ronnie Di Stasio can often be found sitting at the bar with his poodle, Roscoe. The bar-restaurant is really Melbourne in a nutshell: art, booze and the best spiced pigeon cherry pie you'll ever eat. What more could you ask for?
SEE ALSO: One Perfect Day in Melbourne
The Complete Business Travellers' Guide to Melbourne
Your New Cheat Sheet to the Melbourne CBD
SponsoredHow to Have a Perfect Weekend in Bendigo, Sponsored
How to Have a Perfect Weekend in Bendigo
Melbourne's Food Event of the Year Is Here


Hello there! If you haven't quite found what you need, or would like to make a Restaurant booking, fill in our form below or give us a call.
Please note bookings are only available for the restaurant, no other areas of the Surfhouse accept bookings.


text:
4 New Hotels in New York City, Philadelphia and Tysons Corner
Boardroom at Archer Hotel Tysons in Tysons Corner, Virginia. Credit: Archer Hotels
Stay up to date on the latest venue openings and property renovations, including these found in the East.
Offering the largest hotel event space footprint in the Big Apple, New York Hilton Midtown reopened its doors in October. The 1,878-room property is located in the heart of Midtown Manhattan, just steps away from the Museum of Modern Art and only a few blocks away from places like Central Park and Radio City Music Hall.
New York Hilton Midtown. Credit: Hilton
During its closure, the hotel has "redefined and rebranded" its event experience team to serve 150,000 square feet of onsite event space, which includes the largest ballroom in the city plus 47 meeting and event suites.
The property is also offering a "Back to Business" deal: Events booked by December 31, 2021 that occur between November 1, 2021 and March 31, 2022 will receive complimentary event space upgrade and accommodations upgrade, as well as a choice of complimentary WiFi or discounted coffee.
Also up and running in Manhattan is the Pendry Manhattan West, marking the Pendry's first property in New York City. Designed by architectural design firm Skidmore, Owings & Merrill, the hotel features 164 guest rooms, including 30 suites.
Garden Room at Pendry Manhattan West. Credit: Pendry
On site, guests can find food and beverage concepts Bar Pendry, the Garden Room and signature restaurant Zou Zou's, helmed by Chefs Madeline Sperling and Juliana Latif and serving up Eastern Mediterranean fare.
The property also offers a state-of-the-art fitness center with Peloton bikes and more than 6,000 square feet of multi-purpose entertainment and meeting venues. This includes a 1,600-square-foot ballroom, an open concept gallery, a boardroom and an outdoor terrace space filled with greenery.
Earlier this year, the City of Brotherly Love welcomed Live! Casino & Hotel Philadelphia, including its Live! Event Center, a 15,000-square-foot meeting, event and convention space. The hotel itself offers 208 guest rooms, ample onsite parking, 11 dining destinations, as well as gaming and nightly entertainment. The hotel, casino and event center are located in South Philadelphia's Stadium District.
Live! Event Center. Credit: Live! Casino & Hotel Philadelphia
The new Live! Event Center is primed for everything from a one-day meeting to a multi-day conference. Planners can utilize multiple purpose-built event spaces, including the Market Ballroom, which features a high-tech performance stage and an 18-foot ceiling. It can accommodate up to 1,000 attendees. Other spaces include three modern boardrooms and the Liberty Room, ideal for breakout sessions, which can seat up to 100.
Events can also be hosted outside, with rooftop event rentals available atop the property's parking structure, providing amazing views of the city skyline and the Stadium District.
Stylish Boutique Hotel Opens in Virginia's Tysons Corner
Virginia's burgeoning Fairfax County recently welcomed the luxury, new-built property Archer Hotel Tysons in the new Scotts Run South development. This marks the seventh property in Archer's collection and its fourth on the East Coast. The new Archer is located at the foot of the McLean Silver Line Metro Station and is just nine miles northwest of Washington, D.C.
Lobby and AKB Bar at Archer Tysons Corner. Credit: Archer Hotels
The 178-room boutique hotel offers four distinct layouts that include a classic king, double king, a king suite and a "den with balcony" suite, the hotel's largest accommodations.
Archer Tysons also boasts more than 17,000 square feet of indoor and outdoor meeting and event space, with capabilities to host up to 150 attendees in flexible, elegant venues. This includes a stunning seventh-floor penthouse featuring soaring wood-plank ceilings; crystal-clad chandeliers; and the adjoining, mostly covered penthouse terrace, with soft seating, festoon lighting and movable bars.
F&B options include AKB, a restaurant and bar serving breakfast and dinner. Mornings feature freshly roasted Intelligentsia coffee; a full menu of specialty javas served hot, over ice or on the run; and breakfast favorites like avocado toast and even breakfast pizza. In the evenings, guests can expect an extensive bar menu and shareable fare that includes fresh regional seafood and house-made rotisserie chicken.
Read Next: Harrah's Cherokee Casino Resort Completes Expansion, Other Openings in the South
2 New Downtown Denver Hotels, More New and Renovated News Out West
Newport and Providence Are on the Post-Pandemic Comeback Trail
Harrah's Cherokee Casino Resort Completes Expansion, Other Openings in the South


text:
SBHS Store
Teacher Ease
ABOUT SBHS
Principal's Page
SBHS History
Class Bell Schedules
Admission to SBHS
SBHS Video
iPad 1:1 Program
Non-Departmental
Pre AP/AP Courses
SBHS Team Pages
Athletics Policies
Schedules & Results
Seraph Scrolls
Growing up, Mike Miller lived just three blocks east of Saint Bonaventure High School, so following his brother as a Seraph was a foregone conclusion. Even during his grade school years at Assumption, Mike closely followed the Seraphs. What was not clear at the time was that Mike would go on to become one of the most accomplished athletes to ever wear the forest green and gold.
Mike entered SBHS in the fall of 1971. During his four years at SBHS, he excelled as a member of the football and track & field teams. Mike was a truly gifted athlete who possessed both great agility and uncommon speed. In football, Mike starred as a wide receiver and kick return specialist. From his freshman year on, opposing defensive backs quickly learned it was a major mistake to let Mike get a step on them because they would never catch him in the open field. His one handed catch of a punt and return for an 80 yard touchdown against Bishop Diego was a true highlight reel candidate. Following his senior year of football, Mike was named first team all-league and first team all-CIF as a wide receiver. Though Mike's accomplishments on the football field are truly noteworthy, it was as a track and field athlete that he made his major contributions to the Seraph sports legacy.
Mike earned a varsity letter in track and field in each of the four years he attended SBHS. During his freshman year, Mike was a standout as a sprinter. In this regard he was following the path blazed by older brother, Pat (`71), who had been an accomplished sprinter when he attended SBHS. Mike competed in all the sprint events and he even ran middle distance races at times. It was as a sophomore that Mike burst onto the track scene.
As Mike tells the story, one day he was leaving the football field after a physical education class. Jim Bauer, the track coach at the time, asked Mike to remain behind. Coach Bauer directed Mike to run over a flight of low hurdles on the track. This was something Mike had never tried before. When Mike crossed the finish line he turned and walked toward Coach Bauer who was glancing down at the stopwatch in his hand. Coach Bauer looked up and smiled. He then said: "Congratulations. You are now a hurdler."
A few weeks later in his very first hurdle event as a sophomore, Mike broke the school record in the 120 yard high hurdles. This was an especially satisfying moment for Mike because the previous record had been held by Greg Dufresne (`71), who was a good friend and future groomsman in Mike's wedding.
As a sophomore, Mike won most of the varsity hurdle, long jump, and sprint events he entered. Though he generally competed at the varsity level, at the end of the season he finished second in the CIF frosh/soph 120 yard low hurdles. At the time this was the highest finish ever by a SBHS track and field athlete.
During his junior and senior years, Mike was a dominating force on the local track scene. He was one of the fastest sprinters in Ventura County and he was among the best hurdlers in the state. At the Tri-Valley League finals in 1974 and 1975, Mike took first in both varsity hurdle events and the long jump. He was also a member of the winning 440 yard relay team. It is quite likely Mike could have won both varsity sprint events as well, but the rules limited each athlete to no more than four events. Mike was the first SBHS track athlete to ever finish first in four events at a league meet.
As a senior, Mike was the CIF 'AA' champion in the 330 yard low hurdles. Mike failed to qualify in his specialty, the 120 yard high hurdles, after he clipped the first few hurdles. Though he was disappointed and frustrated by his showing in the high hurdles, Mike went on to take first in the 220 yard dash. The victories in those two races marked the first time a Seraph athlete had ever won an individual CIF championship.
Mike went on to run at the CIF Masters Meet in the low hurdles and the 220 yard dash. He was disqualified in the 220 after stepping on the curbing on the inside of lane one but he finished third in the low hurdles and thus qualified for the CIF State Finals Meet. At the State Finals, Mike finished fourth in a photo finish in the 330 yard low hurdles. His time of 37.1 seconds in that race was the tenth fastest time in the nation for that season. Mike was the first Seraph to ever compete in the Masters Meet and the State Finals. It would be many years before another SBHS athlete would ascend to this premier level of competition.
Mike Miller was one of the most accomplished individual Seraph athletes during the early years of the school. He should also be considered one of the best athletes to ever represent SBHS. During his career, he set a great many school records in track and field and he still holds a number of those records.
Following high school, Mike graduated from California State University at Los Angeles. He has spent the last 30 years as a law enforcement officer for the Ventura County Sheriff's Department and the Overland Park Police Department in Kansas. Mike resides in Overland Park with his wife, Patricia, and their three children, Kyle, Kaitlyn, and Christopher.
INDUCTED IN 2009
BACK TO HALL OF FAME
Admin Directory
Faculty Webpages
3167 Telegraph Rd