text:
E-mail: jnnd@annexpublishers.com
Case Report: De novo Ocular Myasthenia Gravis after the mRNA Vaccine for SARS-COV2
Martinez E
Neurology Department, Hospital Comarcal de Vinaroz, Spain
Martinez E, Neurology Department, Hospital Comarcal de Vinaroz Azcárraga M. Family Medicine, Hospital Comarcal de, Spain. Tel: 657328899, E-mail: emiliomartinez72@hotmail.com
, Azcárraga M
Family Medicine, Hospital Comarcal de Vinaroz, Spain
, Maribona A
Medical Student Herbert Wertheim College of Medicine, United States
Copyright: © 2022 Martinez E. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Autoimmune Myasthenia gravis is a neuromuscular junction disease caused by destruction of the acetylcholine receptor on the postsynaptic membrane, mediated by autoantibodies and clinically characterized by skeletal muscle weakness. This can be triggered by drugs, infections, and in rare cases by vaccines. During the COVID pandemic, de novo cases and exacerbations of myasthenia gravis due to viral infection have been documented. Although few cases related to COVID vaccination.
A 69-year-old female patient with blurred vision, a clinic that began 10 days later after receiving first dose of COVID vaccine, and diplopia and right palpebral ptosis after the second dose, 30 days later. In the examination, Edrophonium test was clearly positive, treatment with pyridostigmine and prednisone was started and after 14 days the clinic showed improvement until the resolution of the symptoms
There are few reports of exacerbations or triggers for the appearance of myasthenia gravis, a series of 27 cases has been published where there are outbreaks of immune-mediated diseases or the new appearance of autoimmune diseases, in which it is observed that the time of appearance of the outbreak was on average 4 days up to a maximum of 25 days.
In conclusion, Myasthenia gravis is a rare complication of the BNT162b2 COVID-19 vaccine. Its potential severity and the current lack of knowledge of the real incidence after vaccination makes it necessary to maintain an attitude of vigilance in the face of symptoms that suggest it.
Keywords:Myasthenia Gravis, Autoimmune Disease, SARS-COV2, Eyelid ptosis
Myasthenia gravis (MG) is an autoimmune disease that affects the neuromuscular junction, mediated by circulating antibodies directed against acetylcholine receptors on the motor endplate. Clinically it is characterized by weakness in the extraocular muscles, muscles of bulbar innervation and extremities [1].
The incidence of MG is 1-2 in 100,000 and the prevalence is 5-15 in 100,000. It has a bimodal presentation, being more frequent among women in the second and third decades of life, with a second peak in the fifth decade, where the distribution by sex is equal, although in recent years the cases in the elderly have increased [1].
The disease can be exacerbated and triggered by various factors such as medication, infections and, rarely, vaccines [2-3]. During the COVID-19 pandemic, various observational studies have reported neurological affectations and complications, including MG, although with uncertain direct causality. In some patients, COVID-19 worsened the weakness, leading to a myasthenic crisis. Very infrequently, new-onset autoimmune MG has also been reported after COVID-19 [2-4].
MG patients are considered a high-risk group for the presentation of respiratory failure due to SARS-COV2 infection, both due to the entity itself and due to immunosuppressive treatments, with a higher morbidity and mortality that justifies the recommendation to vaccinate them. However, it is not clear whether the vaccine can trigger a myasthenic crisis or the de novo appearance of autoimmune MG [2,4,5].
We present the case of a woman who developed de novo autoimmune MG after vaccination against SARS-COV2.Clinical case 69-year-old women with a known beta-lactam allergy and a history of hypertension on Olmesartan treatment and no other associated pathology presented in November 2020 with fever, cough without expectoration, fatigue and arthromyalgia. Physical examination was unremarkable. A left basal interstitial infiltrate was observed in the chest X-ray, analytical inflammatory markers were normal, and arterial gasometer did not show signs respiratory failure. PCR for SARS-COV2 was positive. The duration of symptoms was two weeks, but residual fatigue persisted, for which she continued to be followed by the pneumology department. Functional respiratory tests were normal and chest X-ray showed no signs of pneumonia or fibrosis.
Subsequently, the patient received two doses of the BNT162b2 vaccine for COVID-19. The first dose was on 4/9/21, 10 days later the patient noticed blurred vision in the evening or after reading for long periods of time, she even referred double vision. After the second dose, on 4/30/21, she reported worsening symptoms, presenting with binocular diplopia in the evening accompanied by predominantly right eyelid ptosis. At three weeks of evolution, she was evaluated by the neurology department. The physical examination revealed a blood pressure 120/80mmHg, heart rate 70bpm, oxygen saturation 98%, temperature 36.21⁰C, with the rest of the physical examination being unremarkable. Neurologic examination showed patient was conscious and oriented to person, place, and time, no aphasia or dysarthria, no hemianopsia, normal saccades, notable right palpebral ptosis. In the sustained upward gaze diplopia appeared at 10 seconds with bilateral palpebral ptosis and paresis of both superior recti. Remaining cranial nerves normal, muscular strength 5/5 in the four extremities, osteotendinous reflexes present and symmetrical, no sensory or gait disturbances.
Blood tests were unremarkable except for elevated PTH levels. Anti-acetylcholine receptor antibody levels were 20 mg/dl (normal value <0.50). Edrophonium test was clearly positive. A brain CT scan found mild cortico-subcortical atrophy and a thoracic CT effectively ruled out a possible thymoma. The ENG-EMG jitter study, six weeks after our initial assessment, reported no alteration in neuromuscular transmission.
With a diagnosis of ocular myasthenia gravis, treatment with pyridostigmine was started, observing clinical improvement, but diplopia persisted when vision was forced (for example, reading), for which prednisone was added at a dose of 30 mg daily, obtaining a total improvement after 14 days of treatment.
At the present time, after 100 days of treatment, patient remains asymptomatic, without complications and with good tolerance.
Autoimmune MG is a neuromuscular junction disease caused by destruction of the acetylcholine receptor on the postsynaptic membrane, mediated by autoantibodies and clinically characterized by skeletal muscle weakness. There are few descriptions of MG debut after viral infections such as varicella-zoster, West Nile virus, and Zika virus. There are also reports of exacerbations after vaccination, Hung Youl Seok reported 1.5% of exacerbations after influenza vaccination in patients with MG [7]. Dan, He showed that the attenuated virus vaccine for Japanese encephalitis induced the presence of ACRH as well as damage neuromuscular plaque with decreased strength in mice to which said vaccine was applied. This is a reasonable hypothesis because in China the prevalence of infantile myasthenia has a higher prevalence [8].
There are reported cases of new-onset MG after SARS-COV2 infection, with a maximum latency of 56 days. In the case of our patient, 167 days had elapsed after the SARS-COV2 infection, a time delay three times longer than those described, which suggests a relationship with the administration of the two doses of vaccine, rather than with the SARS-COV2 infection [2]. Watad recently published a series of 27 cases of outbreaks of immune-mediated diseases after administration of mRNA vaccine. The delay time in the appearance of outbreaks was four days on average, reaching a maximum of 25 days. In this series, two new-onset MG cases are described, both after the second dose of the BNT162b2 vaccine, one of which was severe, the first patient with moderate symptoms had it on the first day after the second dose and the one who had severe symptoms had it on day seven [3]. Tagliaferri published a case of myasthenic crisis that required endotracheal intubation and assisted ventilation after mRNA- 1273 vaccination [5].
In this case, it is a MG that meets diagnostic criteria, except EMG-Jitter, whose normality may be due to the treatment prescribed in the previous weeks. The temporal relationship between vaccination for SARS-COV2 and the appearance of symptoms of ocular MG suggests a possible trigger for neuromuscular pathology, with a possible pauci symptomatic onset of MG after COVID-19 aggravated by vaccination being more unlikely.
The onset of the clinical symptoms exhibited by this patient is correlated with the administration of the vaccine, but causality cannot be definitively demonstrated.
The proposed mechanisms by which an autoimmune disease is triggered by a vaccine include molecular mimicry and bystander activation. In a model of molecular mimicry involving an mRNA vaccine, the immune system can recognize the antigen produced from the mRNA as similar to the host tissue antigen, resulting in the activation of T cells and the formation of antibodies against host tissue, including the acetylcholine receptor. In this case, the bystander activation model may be more likely. In which, the previously existing antigen is released due to stimulation of the innate immune system as part of the response to the vaccine, resulting in the activation of autoreactive T cells [9].
In conclusion, MG is a rare complication of the BNT162b2 COVID-19 vaccine. Its potential severity and the current lack of knowledge of the real incidence after vaccination makes it necessary to maintain an attitude of vigilance in the face of symptoms that suggest it.
Patient Perspective: Patient perspective and consent.
1Manual de Enfermedades neuromuscular Gutiérrez-Rivas 341-350.
2Reddy YM (2021) Temporal association between SARS-CoV-2 and new-onset myasthenia gravis: is it causal or coincidental? BMJ. 14: e244146.
3Watad A (2021) Outbreaks of immune-mediated disease or new-onset disease in 27 subjects after mRNA / DNA vaccination against SARS-CoV-2. Vaccine (Basilea). Mayo. 9: 435.
4Restivo DA, Centonze D, Alesina A, et al. (2020) Myasthenia gravis associated with SARS-CoV- 2 infection. Ann Intern Med. 173: 1027-8.
5 Tagliaferri A R, Narvaneni S, Azzam M, et al. (2021) A Case of COVID-19 Vaccine Causing a Myasthenia Gravis Crisis. Cureus. 13: e15581.
6Segal Y, Shoenfeld Y (2018) Vaccine-induced autoimmunity: the role of molecular mimicry and immune cross-reaction. Cell. Mol. Immunol. 15: 586–594.
7Seok HY (2017) Impacts of influenza infection and vaccination on exacerbation of myasthenia gravis. J Clin Neurol. 13: 325-330.
8Dan He (2018) Molecular and clinical relationship between vaccination against live attenuated Japanese encephalitis and childhood-onset myasthenia gravis Ann Neurol. Septiembre de. 84: 386-400
9Chavez A, Pougnier C (2021) A case of Covid-19 vaccine associated new diagnosis myasthenia gravis. Journal of Primary Care & Community Health. 12: 1-3
Figure 1: Timeline of evolution of symptoms, test and treatment
Martinez E, Azcárraga M, Maribona A (2022) Epidemiological Approach to Mortal Lesions- Traffic Accident in Yara Municipality, 2007, Cuba. J Neurol Neurol Disord 8(1): 105
Myasthenia Gravis, Autoimmune Disease, SARS COV2, Eyelid ptosis,


With a lot of providers offering web hosting packages, all at different prices, it might be concerning to some organisations when they look for the right package. Once you add in VPS, Dedicated Hosting, MySQL, Apache, VPN, SSL, FTP, BBC, PBS, RSVP and all the other acronyms, you start wishing that everyone would just STFU.
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If you run WordPress on your site, for example, your web server will run the required files, connect to the server's database when it needs to, and present your visitor with the website you wanted them to see. A lot of the code in the WordPress application will require things specifically found on web servers, which is why it won't run properly on your desktop or laptop computer.
Just because it's permanently connected to the Internet, however, doesn't mean that everyone can get access to all of your information. Certain users can access certain areas at any time. Again, if you use WordPress to manage your site, you need to log in to a specific area before you can add any content or delete any content on your site. This is cordoned off by a user login screen, which restricts access to the admin area only to those that are authorised to view it. It knows if you are authorised because you would have a username and password that it recognises, which is encrypted and stored in your database so that nobody can find out what your password really is. This is done on your web server before it ever reaches your computer because the server uses code that your personal computer wouldn't understand.
Why not just have one type of hosting?
That's sometimes just down to good marketing, but more often than not each type of hosting will have limitations to keep costs down. Some companies want more than the basics, or they want servers that can handle a large influx of visitors, and this costs some money.
Cheaper (or even free) services would be perfectly fine for a start-up business or a local community group, and they would readily fit almost all budgets. But once you get more people visiting or you need more functionality, you might want to start looking at some stronger equipment on your side.
So here are just some of the most common types of hosting you will encounter from the majority of web hosts. We're using Unlimited Web Hosting to demonstrate these products, partly because they are our web host, but also because they have the products we are talking about. Like with our post about website domains, we are not being paid by Unlimited Web Hosting, nor are we explicitly recommending their services. There are a great many providers around to get the same products from.
So let's jump right into this.
Shared hosting packages are usually very cheap. You can get what seems like quite a lot for little money. Unlimited Web Hosting, for example, offers its shared hosting package for less than £5 per month, including taxes. Some providers may charge more, some less.
But that low price comes with some significant drawbacks and this is where shared hosting gets its name – you are sharing the server with dozens, possibly even hundreds of other websites. Some providers may even have thousands of websites on one server. That means the hard drive space, the processor speeds, the memory, everything is shared between all of these websites.
That, unfortunately, means that my hugely powerful web application will use the same basic software that your new startup will. So, if I require a lot of resources, I'm restricting what's available for you.
When you're starting up, or if you're just displaying a simple basic website, shared hosting can often be enough, especially when it helps to keep costs down. You won't see any elements of my website on yours, but you might see a dip in performance if my site uses more of the processor.
Reseller hosting packages are essentially shared hosting packages with a few extra tools. As a standard user, you won't need to worry about this, but it allows companies to provide their "own" hosting services, branded with their company's logo and style. Sometimes, the real hosting company will handle support queries on your behalf.
These usually cost more than standard shared hosting packages, but not always by much more. Unlimited Web Hosting, for example, offers their Reseller package for about £15 including taxes.
However, reseller packages aren't really suitable for everyone. If you're looking to sell web hosting as part of your business, then it will be perfect for you. Otherwise, just stay with a standard shared hosting plan.
Ah, the Cloud. The wonder child of web technology. Everyone's heard of the Cloud, it's the best thing in the technical world.
It's also just a bunch of servers connected together, pooling resources and managing them effectively.
Cloud Web Hosting is quite a new hosting technology based on the idea that, as your needs grow, your hosting company can just add more hardware. Like shared hosting, you are sharing the resources with other providers, but unlike shared hosting, you are usually allocated a specific portion of the resources.
Amazon Web Services is very popular Cloud Web Hosting service. They provide you with a complete system where you can add modules as and when you need them, and you are charged only for what you use, rather than one set price for features that you might not use.
Occasionally, shared hosting and Cloud Web Hosting services will work together, especially when asking the Cloud Hosting to take over some of the processing power. Quite often, Cloud Hosting is the next step up after shared hosting.
A virtual private server is similar to shared hosting, except you pay one amount per month for a specific slice of a server's resources. This is a step between shared hosting and your own dedicated web host.
Even though a VPS will share the hardware resources with other accounts, your account is allocated a slice of the resources just for you. Your account will not share any of its allocated processing power with my account, so my powerful website won't bring your site down by overloading the server, and it saves on the costs of a dedicated hosting server.
Unlimited Web Hosting offers two types of VPS accounts: its standard VPS server for just over £10 per month including taxes, or its "Hybrid" server for little over £70 per month including taxes. This steep jump is because its Hybrid server is split into much larger chunks than its standard VPS offering. That means you may only have a dozen different accounts on one Hybrid Server, compared to a hundred on their standard VPS server. This, they claim, gives "performance close to that of a dedicated server but at a lower cost as hardware components can be shared".
Dedicated Web Servers are just that: a server dedicated to you and your site. The hard drive, the memory, the processor, everything on that server has been allocated to running your site. As well as the dedicated hardware, you will usually have full control over how those resources are deployed in your site. Because of this, it's probably best to consider hiring a system administrator to take care of the technical running of the site or get your IT team to look into it (if you have one on board).
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Obviously, you would need to shop around for server costs, but if you are a company that would be in the market for running your own server, you would have the funds available to do this already as well as the team available to put it all together.
Naturally, you're left asking which server is right for you but I am sorry to say that, just like with your domain, the answer is "which one suits your needs?" A new business could easily get away with a shared hosting package, but allocate funds as early as possible for the possibility that you may need to upgrade after a few years. Alternatively, if you are running a huge web app, you would want to have either Cloud Web Hosting or even a dedicated web server to effectively cater for your needs.
Also, Unlimited Web Hosting is not the only provider around that offers these services. Most all major web hosts will offer these services, and some may offer more besides. Speak with the sales team or the technical support team of your provider for more information.
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text:
Тульский камерный драматический театр (сокращенно КДТ) — театр в городе Тула.

История
Театр создан в марте 2005 года режиссёром и актёром Алексеем Басовым, актрисой Еленой Басовой и художником Татьяной Матус. Несмотря на то, что официальное открытие состоялось только в 2005 году, театр ведет свою историю с 1999 года. 10 декабря 1999 года состоялась премьера спектакля «Стеклянный зверинец» на сцене Тульского театра кукол. Именно с этой даты создатели театра отсчитывают его существование.

До 2005 года у КДТ не было своего помещения, из-за чего приходилось перебираться с места на место. С 2000 по 2003 год театр разместился в ДК «Машзавод». До 2004 года, театр базировался в подвале на улице Луначарского. В тот период актёры выступали только на выездных площадках. С 2004 по 2005 год КДТ располагался в помещении Дома офицеров.

В 2005 году театр был зарегистрирован как ЧУК (Частное учреждение культуры) Камерный Драматический театр. С этого момента и по настоящее время арендует помещение по адресу — Тула, ул. Дзержинского, 8.

Бессменным художественным руководителем театра является — Басов Алексей Александрович.

Спектакли

 «Счастливые дни», С. Бэккет. Премьера: 12 ноября 2020 года.
 «Маленькие трагедии», А. С. Пушкин. В спектакль вошли: «Пир во время чумы», «Моцарт и Сальери», «Каменный гость». Премьера: 4 мая 2019 года.
 «Москва — Петушки», В. Ерофеев, режиссёр — Алексей Басов. Премьера: 28 апреля 2018 года.
 «Белые ночи», Ф. Достоевский. Премьера: 30 сентября 2017 года.
 «Пиковая дама», А. С. Пушкин. Премьера: 10 июля 2016 года.
 «АХ…OFF», А. Н. Островский.
 «Любка», Д. Рубина. Премьера: 28 марта 2015 года.
 «Фрёкен Жюли», А. Стриндберг. Драма в 1 действии. Премьера: 30 мая 2013 года.
 «Пять вечеров», А. Володин. Премьера: 26 октября 2012 года.
 «Отель двух миров», Э.-Э. Шмитт. Мистическая драма. Премьера: 26 мая 2011 года.
 «Месье Амилькар платит!!!», Ив Жамиак. Трагикомедия. Премьера: 3 апреля 2008 года.
 «Женитьба Бальзаминова» А. Н. Островский.
 «Про Емелю или по щучьему веленью».
 «Двое на качелях» У. Гибсон.
 «Стеклянный зверинец», Т. Уильямс. Премьера: 10 декабря 1999 года. Повторная премьера к двадцатилетию театра 2019 года.

Участие в фестивалях

 2019 год, Москва: IX Московский театральный фестиваль «Московская обочина». Лучшая мужская роль — Алексей Басов, за роль Венички в спектакле «Москва — Петушки».
 2018 год, Сергиев Посад: V международный театральный фестиваль «У Троицы». Диплом участника.
 2016 год, Москва: Международный театральный фестиваль «ПостЕфремовское пространство».
 2013 год, Кишинёв (Молдова): Международный театральный фестиваль камерных театров «Молдовафест. Рампа. Ру.». Лауреат фестиваля за спектакль «Фрёкен Жюли» Режиссёр — Алексей Басов.
 2010 год, Санкт-Петербург: Межрегиональный фестиваль негосударственных театров и театральных проектов «Рождественский парад»

Ссылки

 Официальный сайт Тульского драматического театра
 Тульский камерный драматический театр представил необычный спектакль, «Вести-Тула»
 «Шведское» вдохновение тульских артистов, «Слобода-Тула»
 Камерный драматический театр Тулы открывает юбилейный сезон
 Тульский театр открыл юбилейный сезон
 Алексей Басов: «Театр нужно строить с нуля»

Примечания

Театры, основанные в 2005 году
Появились в 2005 году в России
Камерные театры России
Частные театры России
Драматические театры Тулы

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Founded by renowned primatologist Dr. Jane Goodall, the Jane Goodall Institute is a global non-profit organization that empowers people to make a difference for all living things. The Institute supports wildlife research, education and conservation, with the primary goal of ensuring the survival of great ape populations through community-centred conservation activities in Africa. The Institute also promotes sustainable livelihoods and nurtures new generations of committed, active citizens around the world.
The Canadian Red Cross Society is a humanitarian organization which does not take sides in hostilities or engage at any time in controversies of a political, racial, religious or ideological nature. The views expressed herein are those of the authors alone and do not necessarily represent the views of The Canadian Red Cross Society.
The David Suzuki Foundation collaborates with Canadians from all walks of life, including government and business, to conserve our environment and find solutions that will create a sustainable Canada through science-based research, education and policy work. The mission of the Foundation is to protect the diversity of nature and our quality of life, now and for the future. The vision of the Foundation is that within a generation, Canadians will be acting on the understanding that we are all interconnected and interdependent with nature.
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text:
Q: Why is my ggseasonplot missing a data point when seasonplot on the same data includes it? When I produce a ggseasonplot using the forecast package using the following data..
tsdata<- structure(c(5515, 5208, 5870, 5553, 5578, 5486, 5141, 5402, 5176,
                   4746, 5401, 5749, 5892, 5994, 6334, 6119, 5891, 6148, 5927,
                   5994,5633, 5150, 5937, 6152, 6619, 6391, 6733, 6454, 6236,
                   6222, 5959, 6265, 6239, 5829, 6335), .Dim = c(35L, 1L), .Dimnames = list(NULL, "Count"), .Tsp = c(2016.33333333333, 2019.16666666667,
 12), class = "ts")

using this code:
forecast::ggseasonplot(tsdata)

The data plots incorrectly - the plotted values aren't correct, Jan 2019 is missing and there are 2 values for Jan 17??
If I plot the identical data using:
forecast::seasonplot(tsdata)

... everything is plotted correctly - I'm baffled - can anyone help with what I'm doing wrong?
(forgive me as I'm relatively new to R and very new to Stack Overflow!)
G

A: There's a floating point issue in the 9th value, which makes it a fraction of a millisecond before 2017:
> options(digits = 16)
> time(tsdata)[9]
[1] 2016.999999999998

I don't know ts well enough to understand how to avoid creating a value like this, but one hack would be to add a fraction of a second to each value...

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I have two lovely people to thank for featuring my work!
I received convos through Etsy from both of them, the first was from the curator of this treasury who included my Native in Heat Treated Copper earrings.
The second was from Hilal at New Moon Studio Ceramics who included my Diamonds and Hearts earrings in her "Lovely Monday! Textures" post. Isn't it pretty?
Congratulations, and they are both lovely pieces!
It was a pleasure! You do have beautiful work! Thank you!


text:
<?php
/**
 * Zcash Status Page
 *
 * @category File
 * @package  ZcashStatus
 * @author   Quentin Le Sceller <q.lesceller@gmail.com>
 * @author   Craig Watson <craig@cwatson.org>
 * @license  https://www.apache.org/licenses/LICENSE-2.0 Apache License, Version 2.0
 * @link     https://github.com/quentinlesceller/zcashd-status
 */

if (!is_file('./php/config.php')) {
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}

require_once './php/config.php';
require_once './php/functions.php';

// Set timezone
if ($config['timezone'] !== null) {
    date_default_timezone_set($config['timezone']);
}

// If we're good to clear cache, remove cache file
if (isset($_GET['clearcache']) & in_array($_SERVER['REMOTE_ADDR'], $config['nocache_whitelist']) & is_file($config['cache_file'])) {
    unlink($config['cache_file']);
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redpajama_set_name: RedPajamaGithub


text:
La pandémie de Covid-19 est une crise sanitaire majeure provoquée par une maladie infectieuse émergente apparue fin 2019 en Chine continentale, la maladie à coronavirus 2019, dont l'agent pathogène est le SARS-CoV-2. Ce virus est à l'origine d'une pandémie, déclarée le  par l'Organisation mondiale de la santé.

La pandémie de Covid-19 en Mongolie démarre officiellement le . À la date du , le bilan est de  morts.

Chronologie

Le premier cas de Covid-19 en Mongolie est confirmé le . Il s'agit d'un homme français de 57 ans, arrivé par avion à Oulan-Bator depuis Moscou. Fiévreux depuis le 7 mars, il lui est demandé de s'isoler à Dornogovi.

Le pallier du 10ème mort est atteint le , le 100ème le  et le 1000ème le .

Articles connexes
 Pandémie de Covid-19 en Asie

Notes et références

Notes

Références

Mongolie
Mongolie
Santé en Mongolie
2020 en Mongolie
2021 en Mongolie
2022 en Mongolie


Fianna Fáil General Election candidate for Dublin South Central Cllr. Catherine Ardagh says more needs to be done to increase awareness of the dangers of drug and alcohol misuse among young people. The candidate, who is also a solicitor, says the recent tragedy in Cork has shone a spotlight on the issue which is also a major issue in Dublin South Central.
Cllr. Ardagh explained, "Drug and alcohol misuse remains one of the biggest dangers to young people in this country. The recent death in Cork has highlighted the scourge of drug abuse, particularly in teenagers and students. This case has reignited the debate about the role of education in preventing drug misuse, and I believe we should be incorporating a drug and alcohol misuse awareness programme in our education system.
"The most effective way of reaching young people is in the school setting. The CSPE curriculum already touches on these issues, but a more targeted approach needs to be adopted. We need an effective, fact based programme, which engages with young people rather than lecturing them.
"I want to see this initiative properly explored and I would like to see teachers and students work together to formulate a strategy which will be effective without talking down or patronising teenagers. If we are to properly tackle the problem of drug and alcohol misuse, we need to engage with young people rather than preaching to them".


text:
Obama Celebrates Nelson Mandela's Legacy In Johannesburg Speech
By Scott Horsley,
Published July 17, 2018 at 10:06 AM CDT
Former President Barack Obama is delivering a speech as we speak in South Africa to mark the centennial of the birth of Nelson Mandela. It is one of Obama's most high-profile appearances since leaving the White House 18 months ago. He warned that what he called the politics of fear are on the move.
BARACK OBAMA: With each day's news cycles bringing more heads spinning and disturbing headlines, I thought maybe it would be useful to step back for a moment and try to get some perspective.
GREENE: Let's get some perspective on this speech from NPR's Scott Horsley, who has been listening in. Hi there, Scott.
SCOTT HORSLEY, BYLINE: Good to be with you, David.
GREENE: So this speech today was not supposed to be overtly political, and Obama has said that Nelson Mandela was really the inspiration for his own political career, right? So it has to be quite a moment for him to be giving this speech. What was his overall message?
HORSLEY: Well, it was in general a hopeful speech. Hope is obviously a part of the Obama brand. He talked about developments over the last century, the spread of opportunity and prosperity. And he talked about how that was sort of symbolized in that moment almost three decades ago when Mandela was released from prison just a couple of months after the Berlin Wall came down.
OBAMA: You'll remember that feeling. It seemed as if the forces of progress were on the march, that they were inexorable.
GREENE: Wow. So this really was a celebration of Mandela's legacy on the eve of what would have been his 100th birthday. But it sounds, though, like Obama also wanted to use this to sort of give a cautionary message, right?
HORSLEY: Absolutely. He said those progressive forces were not inexorable and that even as prosperity and democracy spread, inequality and insecurity came with it. And as a result, he said, around the turn of the century there were a lot of people who missed what would turn out to be a powerful political backlash.
OBAMA: In fact, it is in part because of the failures of governments and powerful elites to squarely address the shortcomings and contradictions of this international order that we now see much of the world threatening to return to an older, a more dangerous, a more brutal way of doing business.
HORSLEY: And that older way of doing business, he said, is characterized by strongman politics, by authoritarianism, by tribalism and xenophobia. The former president did not mention the current President Donald Trump by name, but clearly Trump is emblematic of the movement that Obama was describing here.
GREENE: Interesting. Deciding not to bring up the name of his successor directly but talking more thematically. But I guess there's no hiding what he was sort of addressing there.
HORSLEY: That's right. And this is not the first time Obama has done this. He has generally kept a low profile since he left office, but there have been some exceptions. For example, just a little over a year ago, Obama engaged in a conversation near the Brandenburg Gate in Germany with Chancellor Merkel where he hit on many of these same themes. This has been a long-standing concern for Obama. We heard it in his own exit speech. We heard it in his final address to the United Nations. His story is that the progressives have a story to tell, but they can't take their progress for granted and they need to make that case. And we expect we'll be hearing more from Obama making that case this fall as we get closer to the midterm elections.
GREENE: The midterm elections that are very important to his party. All right. NPR's Scott Horsley.
Scott, we appreciate it.
HORSLEY: Good to be with you, David. Transcript provided by NPR, Copyright NPR.
Morning EditionMorning Edition
Scott Horsley
Scott Horsley is NPR's Chief Economics Correspondent. He reports on ups and downs in the national economy as well as fault lines between booming and busting communities.
See stories by Scott Horsley
David Greene is an award-winning journalist and New York Times best-selling author. He is a host of NPR's Morning Edition, the most listened-to radio news program in the United States, and also of NPR's popular morning news podcast, Up First.
See stories by David Greene

redpajama_set_name: RedPajamaCommonCrawl


Saudi Arabia and Kuwait struggle to resume oil production from joint fields amid souring ties over Turkey, Qatar.
The two countries halted output from the jointly run oilfields - Khafji and Wafra - in the so-called Neutral Zone more than three years ago, cutting some 500,000 barrels per day, or 0.5 percent of global oil supply.
But the sources, who asked not to be identified as they are prohibited from discussing the issue publicly, said the talks failed to move the two countries closer to a deal as Kuwait resisted Riyadh's push for greater control of the fields.
"It did not go well because Kuwaiti sovereignty is non-negotiable," one source told Reuters news agency.
Riyadh does not want Kuwaiti laws to apply to US oil major Chevron, which operates the Wafra onshore field on behalf of the Saudi government, the source added.
Bin Salman met Kuwaiti Emir Sheikh Sabah al-Ahmad al-Jaber al-Sabah and Crown Prince Nawaf al-Ahmad al-Jaber al-Sabah but the visit was cut short from the originally planned two days to just a few hours on the night of September 30, the sources said.
In a move that may complicate relations with Riyadh, Kuwait this month signed a defence cooperation plan with Turkey a move it said was meant to strengthen bilateral ties.
Signed in Kuwait City by top military officials from both countries, the arrangement calls for the exchange of experience and know-how aimed at enhancing military coordination.
Turkey and Saudi Arabia are currently locked in major diplomatic crisis over the disappearance of Saudi journalist Jamal Khashoggi in Istanbul.
Adding to the friction were tensions between Saudi Arabia and Kuwait over the embargo against neighbouring Qatar and diverging views on relations with Saudi Arabia's regional rival Iran.
Kuwait is trying to mediate the embargo, which is being led by Saudi Arabia and the United Arab Emirates.
Kuwait has sought to maintain neutrality, although the Emir's efforts to mediate the rift have had little success so far.
Kuwait, which has a sizeable Shia Muslim minority, has also maintained dialogue with Shia Iran. Saudi Arabia and Iran back opposing sides in civil wars in Syria and Yemen.
"The (regional) situation is not stable, so every country should think how to protect itself," Saleh Ashour, a member of the Kuwaiti parliament, said.
Tensions have been simmering since the last decade when Kuwait was angered by a Saudi decision to prolong Chevron's Wafra concession until 2039 without consulting Kuwait.
In 2014, Saudi Arabia closed Khafji, citing environmental issues. In 2015, Chevron shut Wafra, citing difficulties in securing work permits and materials.
"Saudi Arabian Chevron is focused on supporting operational activities to maintain readiness for production restart when that time comes," a Chevron spokeswoman said.
"Obviously a restart depends on the discussions between the two countries. But we're ready. We are maintaining the equipment, we have put a lot of effort into keeping the pipelines in shape and keeping the key wells in shape."
Shutting off output is expensive because it requires investments of tens of millions of dollars a year for maintenance, sources familiar with field operations said.
The Neutral Zone "is the single biggest asset in the world, which was deliberately stopped and hasn't been producing for three years", one of the sources said.
"The more the restart is postponed the more it will cost to maintain it. And the more problematic it might be to restart the fields quickly and fully," he added.


A difficult experience requires reflection, which the fast-paced university life does not always allow. The past three weeks since returning from Chile have been so fast, and I have not yet had sufficient time to process my summer. My head swirls with the stories I witnessed and questions about what my own role could be in this field. From interviewing both rejected applicants and alumni, I learned Enseña Chile graduates are more diverse in their approach and exposure to education; they operate not only as teachers but also pursue influential positions in government, business, nonprofits, and more. All applicants had a predisposition towards educational issues, however alumni emphasize how the program significantly increased their awareness and appreciation. A few participants did not feel as strongly about their experiences, leading to the question: what are the foundational aspects to a powerful encounter? What might the lukewarm participants have lacked, or are they just different? On the whole, I found many passionate educators in various capacities, struggled with the nature of the work, and found rich insights to answer my original question and more.
I successfully gathered 40 interviews with Enseña Chile alumni, rejected applicants, and current teachers. My survey received 19 responses, and I was able to sit in on one current teacher's classroom. I was often bolstered when, at the end of interviews, the interviewee would express gratitude for my interest and excitement for the results. Many asked for the audio of their interviews afterwards. It was rewarding to feel on track, and that my research was viewed as important and relevant. I often felt satisfied at the end of a long day to have interviewed three, sometimes four affiliates, and have certain phrases and conversations ringing in my head, fomenting ideas and insights. It was simultaneously immensely rewarding to hear about the experiences of this population because I see myself pursuing a similar opportunity in the form of a Fulbright English Teaching Assistant Award. In a sense, I got to explore a plethora of ways that experience might play out, hearing the lessons learned and mistakes made along the way.
My greatest accomplishments occurred during some interviews, where both the interviewee and I would forget my phone recording, and use the interview guide to discuss educational issues as two friends hearing one another out. I remember sitting in a Starbucks one mid-day to interview a woman who transitioned from banking to teaching. She dove into an emotional memory of students calling to her in the hallways as great friends would call to each other. Her eyes welled up, her words quickened, and she began gesticulating passionately, trying to convey this profound encounter she had with these children. In another interview, a participant had a just as emotional but completely different story. The participant spoke coolly, with a straight face, repeating over and over, "It is not what they deserve. It is just not what they deserve." Shaking her head, she would look over my shoulder, eyes fixated on some distant object, and recount her story. These conversations most strongly defined my experience, and in the end, I am simply grateful for the ability to receive these stories and to have them be received.
interviewing was not a part of my target population, and would not qualify for my research. As such, my pool of valid respondents is around 30 instead of the 40 I accomplished, which is much smaller than what I had expected. These facts have caused me to worry about the validity and applicability of my research.
I also found the sense of fundamental separation I observed in the responses of some of the respondents disturbing. Often, the injustices of the education system happen outsideof the affiliate's own lives. Alumni deeply engaged with their school on a professional level, but at the end of the day they returned to their affluent neighborhoods or hung out with college friends or fellow Enseña Chile teachers on the weekends. In that sense, the program is not as immersive as I had expected. There is a sense that these people approach these difficulties from afar, but are never directly impacted.
In regards to my conclusions, the responses I received from alumni and rejected participants were more similar than different in content. There was no definitive difference in the responses between each pool that would differentiate the perspectives of one group from the other. I found a strong number of those rejected had continued on to a career in teaching or tutoring. It is safe to conclude that Enseña Chile generally attracts people interested in education in some capacity, so the question would evolve to be to what extent Enseña Chile accentuates this already established interest. As such, while less Enseña Chile people were expected to teach, they were also expected to pursue positions related to education in government, organizations, policy or otherwise at a higher rate. The majority of alumni entered with a limited teaching background but with a desire to effect positive social change, and exited having decided to pursue a career in or related to education. As a side analysis, from the pace and depth of interviews, I personally ascertained the impression that the responses of the Enseña Chile people had a fuller body, and provided more readily available responses and thorough insights. As I am processing the data now, new questions have emerged. Are there common aspects among the most powerful experiences? What is the quality of these shared experiences: actions, community, and relationships? Will the alumni end up following their expected career trajectory? These beg a better understanding of the comparative experiences of the alumni. It would be immensely enriching to dive deeper into the experiences themselves. As I continue to contemplate these thoughts and give more shape to my conclusions, I plan on exploring further what the post-program desirability for employment Enseña Chile alumni have, in a project that would focus more on the "knowledge economy". Moving forward with transcription and analysis, I will submit my findings to the Human Development Conference as well as prepare a summative document to send to Enseña Chile.
Experiencing the difference in student culture and attitudes towards education in the Latin American context has been of the utmost value in executing this research. I worked with an organization impassioned about the power of education, yet due to stringent inequality, Chile is inflicted with doubts and mistrust about the system, and to an extent, education in general. The work Enseña Chile focuses on is to create leaders and foment relationships within this system in order to improve these conditions. My contact and analysis is positive about the relational and formative aspect of Enseña Chile's work. The teachers speak from their experiences, many found meaning where before they had little direction to their career, and all were challenged but positive about the program. As I move on in my own career, this exposure emphasizes the importance of first getting into the classroom and understanding what it is like to be a teacher to be able to continue in the field of education.


text:
Excitation and Relaxation Dynamics of Two-Dimensional Photoexcited Electrons on Alkanethiolate Self-Assembled Monolayers
Masahiro Shibuta, Naoyuki Hirata, Ryo Matsui, Masato Nakaya, Toyoaki Eguchi, Atsushi Nakajima
The electron dynamics in alkanethiolate self-assembled monolayers (Cn-SAMs; n = 6-18, where n is the number of alkyl carbons) formed on Au(111) surfaces has been investigated by time- and angle-resolved two-photon photoemission spectroscopy. The time evolution of photoexcited electrons flowing down into image potential states (IPSs) formed on standing-up structure of SAMs is resolved two-dimensionally; the electron lifetime in the IPS increases with chain length, from sub-ps to 100 ps. The chain length dependence of the IPS lifetime is particularly marked at shorter chain lengths of n = 6-10, whereas it becomes milder at chain lengths above n = 10, whose alkyl layer thickness is ≈10 Å. This thickness dependence can be explained by two competitive channels for the decay of IPS electrons: one is electronic coupling of IPS with unoccupied bulk Au states and an interfacial state localized at the Au-S linkage, and the other is IPS electron decay to the Au substrate through a tunneling barrier of insulating alkyl chains. The former is most influential at shorter chain lengths, while the latter is solely dominant at longer chain lengths. In addition, the photon energy dependence of the IPS intensity revealed that electron injection into the IPS is mediated effectively by an electron excitation into interfacial resonance formed in the alkyl layer.
https://doi.org/10.1021/acs.jpcc.5b06549
Published - 2015 Oct 8
Self assembled monolayers
Electron energy levels
electron states
Electron injection
Photoelectron spectroscopy
life (durability)
photoelectric emission
Shibuta, M., Hirata, N., Matsui, R., Nakaya, M., Eguchi, T., & Nakajima, A. (2015). Excitation and Relaxation Dynamics of Two-Dimensional Photoexcited Electrons on Alkanethiolate Self-Assembled Monolayers. Journal of Physical Chemistry C, 119(40), 22945-22953. https://doi.org/10.1021/acs.jpcc.5b06549
Excitation and Relaxation Dynamics of Two-Dimensional Photoexcited Electrons on Alkanethiolate Self-Assembled Monolayers. / Shibuta, Masahiro; Hirata, Naoyuki; Matsui, Ryo; Nakaya, Masato; Eguchi, Toyoaki; Nakajima, Atsushi.
Shibuta, M, Hirata, N, Matsui, R, Nakaya, M, Eguchi, T & Nakajima, A 2015, 'Excitation and Relaxation Dynamics of Two-Dimensional Photoexcited Electrons on Alkanethiolate Self-Assembled Monolayers', Journal of Physical Chemistry C, vol. 119, no. 40, pp. 22945-22953. https://doi.org/10.1021/acs.jpcc.5b06549
Shibuta M, Hirata N, Matsui R, Nakaya M, Eguchi T, Nakajima A. Excitation and Relaxation Dynamics of Two-Dimensional Photoexcited Electrons on Alkanethiolate Self-Assembled Monolayers. Journal of Physical Chemistry C. 2015 Oct 8;119(40):22945-22953. https://doi.org/10.1021/acs.jpcc.5b06549
Shibuta, Masahiro ; Hirata, Naoyuki ; Matsui, Ryo ; Nakaya, Masato ; Eguchi, Toyoaki ; Nakajima, Atsushi. / Excitation and Relaxation Dynamics of Two-Dimensional Photoexcited Electrons on Alkanethiolate Self-Assembled Monolayers. In: Journal of Physical Chemistry C. 2015 ; Vol. 119, No. 40. pp. 22945-22953.
@article{d0598ddc142143789e1ea2c0cd018246,
title = "Excitation and Relaxation Dynamics of Two-Dimensional Photoexcited Electrons on Alkanethiolate Self-Assembled Monolayers",
abstract = "The electron dynamics in alkanethiolate self-assembled monolayers (Cn-SAMs; n = 6-18, where n is the number of alkyl carbons) formed on Au(111) surfaces has been investigated by time- and angle-resolved two-photon photoemission spectroscopy. The time evolution of photoexcited electrons flowing down into image potential states (IPSs) formed on standing-up structure of SAMs is resolved two-dimensionally; the electron lifetime in the IPS increases with chain length, from sub-ps to 100 ps. The chain length dependence of the IPS lifetime is particularly marked at shorter chain lengths of n = 6-10, whereas it becomes milder at chain lengths above n = 10, whose alkyl layer thickness is ≈10 {\AA}. This thickness dependence can be explained by two competitive channels for the decay of IPS electrons: one is electronic coupling of IPS with unoccupied bulk Au states and an interfacial state localized at the Au-S linkage, and the other is IPS electron decay to the Au substrate through a tunneling barrier of insulating alkyl chains. The former is most influential at shorter chain lengths, while the latter is solely dominant at longer chain lengths. In addition, the photon energy dependence of the IPS intensity revealed that electron injection into the IPS is mediated effectively by an electron excitation into interfacial resonance formed in the alkyl layer.",
author = "Masahiro Shibuta and Naoyuki Hirata and Ryo Matsui and Masato Nakaya and Toyoaki Eguchi and Atsushi Nakajima",
doi = "10.1021/acs.jpcc.5b06549",
T1 - Excitation and Relaxation Dynamics of Two-Dimensional Photoexcited Electrons on Alkanethiolate Self-Assembled Monolayers
AU - Shibuta, Masahiro
AU - Hirata, Naoyuki
AU - Matsui, Ryo
AU - Nakaya, Masato
AU - Eguchi, Toyoaki
AU - Nakajima, Atsushi
N2 - The electron dynamics in alkanethiolate self-assembled monolayers (Cn-SAMs; n = 6-18, where n is the number of alkyl carbons) formed on Au(111) surfaces has been investigated by time- and angle-resolved two-photon photoemission spectroscopy. The time evolution of photoexcited electrons flowing down into image potential states (IPSs) formed on standing-up structure of SAMs is resolved two-dimensionally; the electron lifetime in the IPS increases with chain length, from sub-ps to 100 ps. The chain length dependence of the IPS lifetime is particularly marked at shorter chain lengths of n = 6-10, whereas it becomes milder at chain lengths above n = 10, whose alkyl layer thickness is ≈10 Å. This thickness dependence can be explained by two competitive channels for the decay of IPS electrons: one is electronic coupling of IPS with unoccupied bulk Au states and an interfacial state localized at the Au-S linkage, and the other is IPS electron decay to the Au substrate through a tunneling barrier of insulating alkyl chains. The former is most influential at shorter chain lengths, while the latter is solely dominant at longer chain lengths. In addition, the photon energy dependence of the IPS intensity revealed that electron injection into the IPS is mediated effectively by an electron excitation into interfacial resonance formed in the alkyl layer.
AB - The electron dynamics in alkanethiolate self-assembled monolayers (Cn-SAMs; n = 6-18, where n is the number of alkyl carbons) formed on Au(111) surfaces has been investigated by time- and angle-resolved two-photon photoemission spectroscopy. The time evolution of photoexcited electrons flowing down into image potential states (IPSs) formed on standing-up structure of SAMs is resolved two-dimensionally; the electron lifetime in the IPS increases with chain length, from sub-ps to 100 ps. The chain length dependence of the IPS lifetime is particularly marked at shorter chain lengths of n = 6-10, whereas it becomes milder at chain lengths above n = 10, whose alkyl layer thickness is ≈10 Å. This thickness dependence can be explained by two competitive channels for the decay of IPS electrons: one is electronic coupling of IPS with unoccupied bulk Au states and an interfacial state localized at the Au-S linkage, and the other is IPS electron decay to the Au substrate through a tunneling barrier of insulating alkyl chains. The former is most influential at shorter chain lengths, while the latter is solely dominant at longer chain lengths. In addition, the photon energy dependence of the IPS intensity revealed that electron injection into the IPS is mediated effectively by an electron excitation into interfacial resonance formed in the alkyl layer.
U2 - 10.1021/acs.jpcc.5b06549
DO - 10.1021/acs.jpcc.5b06549
10.1021/acs.jpcc.5b06549


text:
Q: How to round out corners when using CSS clip-path I want to be able to round out the 3 leftmost corners on this shape that I have created, any idea how that can be done?

div {
  position: absolute;
  z-index: 1;
  width: 423px;
  height: 90px;
  background-color: #b0102d;
  color: white;
  right: 0;
  margin-top: 10vw;
  -webkit-clip-path: polygon(100% 0%, 100% 50%, 100% 100%, 25% 100%, 0% 50%, 25% 0%);
  clip-path: polygon(100% 0%, 100% 50%, 100% 100%, 25% 100%, 0% 50%, 25% 0%);
}

A: I've recently found success experimenting with approaches like this...
SVG
<svg width="0" height="0">
  <defs>
    <clipPath id="clipped">
      <circle cx="var(--myRad)" cy="var(--myRad)" r="var(--myRad)"></circle>
      <circle cx="var(--myRad)" cy="calc(var(--myHeight) - var(--myRad))" r="var(--myRad)"></circle>
      <circle cx="calc(var(--myWidth) - var(--myRad))" cy="calc(var(--myHeight) - var(--myRad))" r="var(--myRad)"></circle>
      <circle cx="calc(var(--myWidth) - var(--myRad))" cy="var(--myRad)" r="var(--myRad)"></circle>
      <rect y="var(--myRad)" width="var(--myWidth)" height="calc(var(--myHeight) - (2 * var(--myRad)))"></rect>
      <rect x="var(--myRad)" width="calc(var(--myWidth) - (2 * var(--myRad)))" height="var(--myHeight)"></rect>
    </clipPath>
  </defs>
</svg>

CSS
.clipped {
  --myWidth: 100vw;
  --myHeight: 10rem;
  --myRad: 2rem;
  clip-path: url(#clipped);
}

I found this useful as compared to using border-radius with overflow set to hidden, because this approach doesn't create a BFC or break things like sticky position and css perspective effects. Also, this allows you to "inset" the position of the svg paths to clip inside the element with a "corner-radius" if you want.

A: You can also mess around with the circle to get some different effects.
-webkit-clip-path: circle(60.0% at 50% 10%);
clip-path: circle(50.0% at 50% 50%);

Codepen
Too bad you can't combine the polygon and circle... or maybe you can and I haven't played around with it enough to figure it out. HTH

A: clip-path: inset(45% 0% 33% 10% round 10px)

A: use inset with round property :
inset(0% 45% 0% 45% round 10px)

A: An SVG filter can round any kind of clip-path. You simply need to apply it to a parent element. Adjust the stdDeviation to control the radius:

.box {
  width: 423px;
  height: 90px;
  background-color: #b0102d;
  color: white;
  clip-path: polygon(100% 0%, 100% 50%, 100% 100%, 25% 100%, 0% 50%, 25% 0%);
}

.parent {
  filter: url('#goo');
  overflow:hidden;
  position: fixed;
  right:-50px;
  z-index: 1;
  margin-top: 10vw;
}

<svg style="visibility: hidden; position: absolute;" width="0" height="0" xmlns="http://www.w3.org/2000/svg" version="1.1">
  <defs>
        <filter id="goo"><feGaussianBlur in="SourceGraphic" stdDeviation="8" result="blur" />
            <feColorMatrix in="blur" mode="matrix" values="1 0 0 0 0  0 1 0 0 0  0 0 1 0 0  0 0 0 19 -9" result="goo" />
            <feComposite in="SourceGraphic" in2="goo" operator="atop"/>
        </filter>
    </defs>
</svg>

Related: https://stackoverflow.com/a/65485455/8620333

A: I don't have a comment option yes, so I'm writing it as an answer..
you need to write as many points as possible to round the corner. Nothig else...
for, example a few more points to make lower part bit rounder:
-webkit-clip-path: polygon(100% 0%, 100% 100%, 100% 100%, 25% 100%, 5% 70%,1% 60%, 0% 50%, 25% 0%);

oh, yes, or SVG as comment people here.. :)

A: You could use a child element and do a nested clip-path on that and the child's pseudo element. The parent will do a polygon clip on the shape first, then the pseudo will have an ellipse to round the borders. The clips will have a combined effect.

.parent, .parent div, .parent div:before {
  width: 423px;
  height: 90px;
  position: absolute;
}

.parent {
  right: 0;
  background-image: linear-gradient(to right, transparent 210px, #b0102d 210px);
  margin-top: 15vh;
}

.parent div {
  clip-path: polygon(100% 0%, 100% 100%, 25% 100%, 0 50%, 25% 0);
}

.parent div:before {
  content: "";
  background-color: #b0102d;
  clip-path: ellipse(200px 45px at 210px);
}

Here is the demo with some adaptations to illustrate what's going on:

.parent, .parent div, .parent div:before {
  width: 423px;
  height: 90px;
  position: absolute;
}

.parent {
  right: 0;
  background-image: linear-gradient(to right, transparent 210px, yellow 210px);
  margin-top: 15vh;
}

.parent div {
  background-color: blue;
  clip-path: polygon(90% 0%, 90% 100%, 25% 100%, 0 50%, 25% 0);
}

.parent div:before {
  content: "";
  background-color: #b0102d;
  clip-path: ellipse(200px 45px at 210px);
}

The horizontal size and position of the ellipse can be used to get a different effect on the edges. Note that the background starting postion of the parent needs to be adjusted to the same value as the placement of the ellipse (last value in the clip-path) because it fills up whatever gets clipped off on the right side. This can be visualised by removing background-color: blue from .parent div in the second demo.
Here is an additional Codepen to to try it out.