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Turkey surrounded by terrorism
By Manolis Kostidis / 09/01/2017 / Comments Off on Turkey surrounded by terrorism
Erdogan's dead ends and the collapse of Turkey's tourism
The Republic of Turkey is faced with of the most difficult periods since its establishment in 1923, with the country facing multiple threats and attacks and the Turkish government seeing enemies everywhere, resulting in thousands of arrests and prosecutions of Turkish citizens.
The President of Turkey Recep Tayyip Erdogan went so far as to call the people to mobilization and stated that "Turkey launches a new liberation struggle", similar to that of Kemal Atatürk. In this case however, it is not clear who the enemy is, so in Turkey they refer to all terrorist organizations that have made 34 terrorist attacks within 1.5 years. The pro-government media speak of "foreign forces", "foreign centers" that have targeted Erdogan, while the government accuses the US of arming the Kurds of northern Syria.
How Turkey became a target of terrorist organizations
The situation that Turkey is in, suffering terrorist attacks from Kurds, jihadists and having been faced with an attempted coup, raise many questions.
The president of the main opposition Kemal Kılıçdaroglu directly accused the government of supporting the jihadists! "You sent weapons to Syria and now all of these are in Turkey. You provided care in public hospitals to those who got injured. You have channels of communication with Al Nusra", he said.
The Republican People's Party (CHP) accuses Erdogan of violating the basic principle of the Turkish Republic of not getting involved in the internal affairs of another country.
With the outbreak of the fighting in Syria Ankara provided support to opposition forces, since the aim was the overthrow of Bashar al-Asad. "In a few months we will pray together with our brothers in Aleppo", had declared the former Prime Minister Ahmet Davutoglu.
Despite his defeats, Asad has remained in power and with the help of Russia Aleppo is once again under the control of government forces.
In order to prevent the creation of a single Kurdish zone in northern Syria Turkey has invaded Syria and began to fight against the Islamic State (ISIS), which controls the city Al Bab. In order to do this however, it came to an agreement with Moscow and Tehran, cutting all aid to the Syrian opposition forces. As a result, the militants fighting Asad believe they were "betrayed" by Erdogan who supported them until the agreement with Putin.
"In the Turkish government there is the assessment that the New Year's hit is the work of the core of the Islamic State located in Turkey. The Islamic State, with the pressure of the Turkish army, has been removed and its members cannot cross the border any more. At the same time, the US has been left out of the game in Syria. Aleppo was evacuated after the Russia-Turkey cooperation. The truce was reached again in the same manner. The US has been left out. It is estimated that the terrorist attacks of the PKK in Kayseri and Beşiktaş, the murder of the Russian ambassador from the terrorist organization FETÖ and the attack at the night club Reina are not unrelated to developments", says Abdülkadir Selvi in an article in the newspaper Hürriyet.
The Turkish government accuses the US places its trust in Trump
Essentially, the columnist levels many accusations for these terrorist attacks to the US, without of course documenting them.
The Turkish government will try to take advantage of Trump's election to change Washington's policy in relation to the Kurds, but also the issue of Gulen. Besides, the Turkish Prime Minister Binali Yildirim clarified that "the US should not cooperate with terrorist organizations, but work with Turkey that is fighting them. If they do not change policy however, we will proceed alone. The US must stop this absurdity", stressed the Turkish Prime Minister.
Political analysts say that an unorthodox alliance between Moscow, Ankara and Tehran has been created, which changes the balances in the Middle East. Questions remain as to the position of countries like Egypt, Saudi Arabia, Qatar and of course the US.
The Muslim brothers and Erdogan
The thing that troubles many people in Turkey is the support from part of the public opinion in the country to the Islamic State for its attacks. "There was a turmoil within the ruling AKP party, with the thought that some in Turkey, perhaps the taxi driver, the greengrocer, support passionately these terrorist attacks. Indeed, opinion polls had shown that 8% of Turks was sympathetic towards the Islamic State when it published a video beheading people", writes Murat Yetkin in Hurriyet.
"The theoretical minds of Ankara, when they were estimating the situation in Syria in 2013, saw only the Muslim Brotherhood and believed they would overthrow Assad. They failed to see how the Muslim Brotherhood dissolved in Syria when they were overthrown with a coup in Egypt. They did not realize they all these joined Al Nusra and the Islamic State. Ankara did not see this", adds the experienced political analyst of the Turkish newspaper.
However, analysts say that the old policy of Turkey in Syria ended November 24, 2015, with the shooting down of the Russian warplane. And the new policy in Syria began after the normalization of relations with Israel and Russia in July 2016.
"Despite the threats, Ankara did not consider the Islamic State as an important threat as they did the PKK and the FETO terrorist organisation. After January 1, Ankara considers the Islamic State as big a threat as the other terrorist organizations", Turkish analysts say./IBNA
By: Manolis Kostidis
Last Modified: January 9, 2017 @ 1:32 pm
Filed Under: Headlines, Politics, Social, TR Politics, TR Social, Turkey
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Manolis Kostidis
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Q: Center a div container without setting width I am trying to center my div responsively. But I am unable to do it without setting a width...

Content

Content

.wrapper {text-align:center}
.container {width:100%; margin: 10px auto}
.left {width:69%;max-width:350px; background:blue}
.right {width:29%;max-width:150px; background:red}
.box {float:left;padding:20px}

How can I keep the .container in the middle ?
Demo: http://jsfiddle.net/z9zydnwL/

A: i think you should use the below css

.wrapper {
  width: 100%;
  text-align: center
}
.container {
  margin: 10px auto;
  font-size: 0;
}
.left {
  width: 69%;
  max-width: 350px;
  background: blue
}
.right {
  width: 29%;
  max-width: 150px;
  background: red
}
.box {
  display: inline-block;
  padding: 20px;
  font-size: 16px;
}

Content

Content

A: Yes you can put a div in center without using width property as per your need.
Say you have some content with variable width. If it is just text, you can probably get away with text-align:center. But say it is an image, and that image may have different dimensions. How do you consistently center it on the page?
First, put the content inside a floated div, because floated divs will shrink wrap around the content. Second, wrap that div in another floated div.
Now here's the good part. Relatively position the outer float (yellow) left:50%, so that the left edge is at the middle of the page. Then relatively position the inner float (red) left:-50% to shift it exactly 1/2 of the yellow div's width to the left, so that it is centered. Note that the yellow div and the red div are exactly the same width, because the yellow is also a float, so it is shrink wrapped to fit around the red one.
The background colors and heights are included to make it clear what is happening. Normally, the yellow div would have no height spec and no padding, and would be set to your background color. The red div is the one that we are trying to center.
For reference you can check link
http://www.tightcss.com/centering/center_variable_width.htm
Sample example to show how it works

    .container
     {
      float: left;
            position: relative;
            left: 50%;
            padding-top: 10px;
     }
     .center {
            float: left;
            position: relative;
            left: -50%;
            background: red;

    }

sample content

A: You are having the padding value in .box. So, the left and right boxes width wouldn't fit as well. Try reducing the width value then it must works:
.wrapper {text-align:center}
.container {width:100%; margin: 10px auto}
.left {width:67%;max-width:350px; background:blue}
.right {width:27%;max-width:150px; background:red}
.box {float:left;padding:20px}

A: You can try the below style by replacing your float left with display: inline-block;
.wrapper {width:100%; text-align:center}
.container {margin: 10px auto; font-size: 0}
.left {width:69%;max-width:350px; background:blue}
.right {width:29%;max-width:150px; background:red}
.box{
    display: inline-block;
    font-size: 14px;
    padding: 20px 0;
}

Working Fiddle

A: Instead of floating the boxes, use
display: inline-block;

See the DEMO.

A: Flexbox can even center floated children!
So I can simply add display:flex and justify-content: center; to the container
.container {
    margin: 10px auto;
    display:flex;
    justify-content: center; /* align horizontal */
}

FIDDLE
Browser support these days is also good

.wrapper {
  width: 100%;
  text-align: center
}
.container {
  margin: 10px auto;
  display: flex;
  justify-content: center;
  /* align horizontal */
}
.left {
  width: 69%;
  max-width: 350px;
  background: blue
}
.right {
  width: 29%;
  max-width: 150px;
  background: red
}
.box {
  float: left;
  padding: 20px
}

Content

Content

A: One solution is to replace float with inline-block:

.wrapper {
  text-align: center
}
.container {
  margin: 10px auto;
  font-size: 0;
}
.left {
  width: 69%;
  max-width: 350px;
  background: blue
}
.right {
  width: 29%;
  max-width: 150px;
  background: red
}
.box {
  display: inline-block;
  padding: 20px;
  font-size: 16px;
}

Content

Content

redpajama_set_name: RedPajamaStackExchange


Create beautiful combinations of blue and orange flowers in pots with some of the names suggested here!
Blue flowers are really eye-catching and goes well with most of the flowers of other colors. If you're thinking about creating a combination of blue flowers with others, you can go with red, white or pink but one of the most appealing color that would really pop is Orange.


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Aparthotel Adagio Liverpool City Centre
1 Fairclough Street Liverpool L1 1FS United Kingdom
Brand-new aparthotel in Liverpool's iconic Lewis's building
We're sorry, but Aparthotel Adagio Liverpool City Centre is temporarily unavailable. Please try again in a few minutes or search for more hotel deals above.
A 5-minute walk from the Royal Court Theatre and other main attractions
Apartments have fully equipped kitchens and sleep between 2 & 6 people -- great for families & groups
Great transport links -- near Liverpool Central & Liverpool Lime Street train stations
The Aparthotel Adagio Liverpool City Centre is in the iconic Lewis's Building in the heart of the city, within walking distance of many of Liverpool's most popular attractions, so a great base from which to explore the city. With apartments that sleep from two to six people, it is a particularly good choice for families and groups.
Liverpool is home to more museums and galleries than any other city in the UK outside of London, including the largest newly built national museum in the UK, the contemporary 2012 Liverpool City Regional Annual Tourism Award-winning Liverpool Museum -- which is less than a mile from the Aparthotel Adagio Liverpool City Centre. The Tate Liverpool gallery, until 2003 the largest gallery of contemporary art in the UK outside of London, is a 15-minute walk away. Both have free entry, although exhibits cost extra.
The aparthotel is 4-minute walk from the Royal Court Theatre and a 9-minute walk from the Cavern Club, within the fashionable Cavern Quarter shopping area -- "a mecca for Beatles fans", according to Lonely Planet. The property has good public-transport links, as it is next to Liverpool Central train station and Liverpool Lime Street station is a 5-minute walk away.
The hotel has studios that sleep up to two people, 1-bedroom apartments that sleep up to four people and 2-bedroom apartments that sleep up to six. Each apartment has a fully equipped kitchen, comprising a fridge-freezer, a microwave with grill, ceramic hob and a dishwasher, and include crockery, utensils and cleaning materials -- additional utensils (toaster, rice cooker, etc) are available on request. All apartments are air-conditioned and have free Wi-Fi and flat-screen televisions.
The hotel gym is open from 7am until midnight. The laundry and reception area are both open 24 hours a day.
1 Fairclough Street
Liverpool L1 1FS
Fee for buffet breakfast: GBP 13 for adults and GBP 6.25 for children (approximately)
Pet fee: GBP 13 per pet, per night
Early check-in fee: GBP 20.00 (subject to availability)
Mandatory Fees and Taxes
Breakage deposit: GBP 100 per stay
Customer service available Monday - Friday 9am - 6pm GMT + 8.
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redpajama_set_name: RedPajamaCommonCrawl


It seems that, recently, the purpose of this forum has escaped a few people.
The Tutorials forum is for posting tutorials on aspects of modding the RA2/YR game, and not a forum for requesting help.
If you need help and cannot find a suitable tutorial, please post it in the relevant editing forum, but NOT HERE.
Anything posted in here by error will in future be moved without leaving a link.


text:
Q: What do I need to write a Physics Engine? This is a VERY basic question. I want to start writing a physics engine. I have found a bunch of websites telling me how, but I havent found what I need.
What I want to know is what software I need to write a physics engine and see it working (see the shapes running into each other). I have Eclipse on my computer, can I use that?

A: BTW, it may be a better idea to post this to https://gaming.stackexchange.com/
However, as the name suggests:

*

*You'll need an understanding of Physics. How deep you wish to go with that is up to you as Physics is the study of the natural world so it automatically encompasses study of very large things (clusters of galaxies, galaxies, nebulae, etc.) to very small things (atoms, quarks, etc.). Hence, the Physics gets very exotic very quickly (i.e. you start dealing with Quantum Mechanics, String Theory, Relativistic Mechanics, etc.). But, something to keep in mind is that most Physics in game engines use Newtonian Mechanics. So, my suggestion is begin there.

*Next, you have to decide what language your engine is going to be in. Most people usually design the engine in the same language as the language the game logic is written in. But, that's not necessarily true. Mainly, the language you develop your engine in is going to be limited to what problems you want your engine to address in addition to the engine's speed, ease of use, ease of development, maintainability, etc. As you would expect, this often means that the development of a Physics Engine is an ambitious and time-consuming endeavor as most aspects of the engine set the limits for how the game will be designed.

*Once you've made all those choices, next you have to figure out how you wish to implement your engine (e.g. using Procedural compared to Object Oriented methodologies). But, that again is going to be limited to the language you choose. However, it should be noted that each methodology has its merits and bad points. You'll have to research the methodologies based on what problems you wish to address in your game engine. Example: if all your game does is projectile motion, then create a game that implements equations to solve projectile motion equations.
Of course it's more involved than this, but it should give you an idea of where to begin and what to do. And, it should be noted that this is keeping in mind that standard software development methods should be addressed at all times: maintainability, unit-tests, code backup (via repositories), etc.
SUMMARY:

*

*Your engine is going to be limited to the language you develop it in.

*The language you develop it in is going to be limited to the problems you want to address with your engine. Problems being: speed, ease of development, accuracy, maintainability, etc.

*Most Physics Engines are based on Classical Mechanics.


text:
Javits, stadium plan to be announced
The city, state and the Jets football team have reached a tentative agreement to expand the Jacob K. Javits Convention Center and build a stadium on the West Side.
The two megaprojects, which together will top $2.5 billion, are elements of a city plan to extend the midtown office hub west to the Hudson River. A privately funded, $300 million convention hotel at 11th Avenue and West 42nd Street is also envisioned.
The city and state have said they will pay $600 million each to help finance the project. The Jets would pay $800 million, and $500 million would be generated through a proposed $1.50-a-night hotel room tax.
Bonds issued to finance the project will require approval of the Public Authorities Control Board, a panel made up of Gov. George Pataki, Assembly Speaker Sheldon Silver and state Senate President Joseph Bruno. The board may not be a rubber stamp for the projects.
The New York state Legislature will also be required to vote on several pieces of legislation to move the projects forward, including raising the city hotel tax.
Sponsored Content: Crain's Content Studio Presents: CFO Forecast


The item Halogenated organics study for Allen, Kingston, and Shawnee Steam Plants, by C. V. Seaman ... [and others] ; prepared for U.S. Environmental Protection Agency, Office of Research and Development represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Houston Public Library.
"Interagency agreement no. D5-E721, program element no. 1NE624A."


Women of the Vine & Spirits, a leading trade alliance devoted to the advancement of women in the alcohol beverage industry and advocating for diversity initiatives will facilitate the first of its kind gathering of top male and female executives in the alcohol beverage industry for its inaugural Executive Summit, held September 13, at City Winery in New York City.
The Executive Summit will focus on topics and best practices for starting or growing an internal women's leadership initiative. Topics to include Organizational Structure, Elements of an Effective Women's Initiative, Workplace Diversity, Succession Planning, Financial Equality, How to Start and Run a Successful Mentoring Program, How to Measure Program Effectiveness, and others.
Women of the Vine & Spirits found there was a lack of available and current data in the US and abroad of the number women in leadership roles in the alcohol beverage industry. Understanding that women control $4.3 trillion of the $5.9 trillion in annual consumer spending, and that women consumed 60.2% of total wine consumption in the US last year, Women of the Vine & Spirits is taking the initiative to gather this data by surveying its Corporate Partners, which are some of the leading wine and alcohol beverage brands in the world. The organization plans to monitor this data over time and analyze its findings each year at the annual Executive Summit.
Participating in this year's Summit are industry leaders including Pete Carr, President, Bacardi U.S.A., Inc.; Ann Giambusso, Executive Vice President, Chief Human Resources Officer at Breakthru Beverage Group; Rick Gillis, President, Young's Market Company; and Barkley J. Stuart, Executive Vice President, Director, Government Affairs, Southern Glazer's Wine & Spirits, among others.
For more information about the Executive Summit, how to become a Corporate Partner or Member of Women of the Vine & Spirits, visit womenofthevine.com.


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Investor Relations Officer Average Salary in Moldova 2022
How much money does an Investor Relations Officer make in Moldova?
29,100 MDL
( 350,000 MDL yearly)
MDL AVERAGE
MDL HIGH
A person working as an Investor Relations Officer in Moldova typically earns around 29,100 MDL per month. Salaries range from 13,400 MDL (lowest) to 46,300 MDL (highest).
This is the average monthly salary including housing, transport, and other benefits. Investor Relations Officer salaries vary drastically based on experience, skills, gender, or location. Below you will find a detailed breakdown based on many different criteria.
Investor Relations Officer Salary Distribution in Moldova
Tweet Get Chart Linkhttp://www.salaryexplorer.com/charts/moldova/public-relations/investor-relations-officer/median-and-salary-distribution-monthly-moldova-investor-relations-officer.jpg
Investor Relations Officer salaries in Moldova range from 13,400 MDL per month (minimum salary) to 46,300 MDL per month (maximum salary).
The median salary is 31,500 MDL per month, which means that half (50%) of people working as Investor Relations Officer(s) are earning less than 31,500 MDL while the other half are earning more than 31,500 MDL. The median represents the middle salary value. Generally speaking, you would want to be on the right side of the graph with the group earning more than the median salary.
Closely related to the median are two values: the 25th and the 75th percentiles. Reading from the salary distribution diagram, 25% of Investor Relations Officer(s) are earning less than 20,200 MDL while 75% of them are earning more than 20,200 MDL. Also from the diagram, 75% of Investor Relations Officer(s) are earning less than 42,000 MDL while 25% are earning more than 42,000 MDL.
10 salary negotiation tips everyone should know 13 deadly interview mistakes that can cost you the job 9 deadly resume mistakes that you must avoid 25 simple money saving tips ($15000+ in savings!) 7 unconventional and creative job hunting techniques
Investor Relations Officer Salary Comparison by Years of Experience
Tweet Get Chart Linkhttp://www.salaryexplorer.com/charts/moldova/public-relations/investor-relations-officer/salary-comparison-by-years-of-experience-monthly-moldova-investor-relations-officer.jpg
The experience level is the most important factor in determining the salary. Naturally the more years of experience the higher your wage. We broke down Investor Relations Officer salaries by experience level and this is what we found.
An Investor Relations Officer with less than two years of experience makes approximately 15,200 MDL per month.
While someone with an experience level between two and five years is expected to earn 20,300 MDL per month, 34% more than someone with less than two year's experience.
Moving forward, an experience level between five and ten years lands a salary of 30,000 MDL per month, 48% more than someone with two to five years of experience.
Additionally, Investor Relations Officer(s) whose expertise span anywhere between ten and fifteen years get a salary equivalent to 36,600 MDL per month, 22% more than someone with five to ten years of experience.
If the experience level is between fifteen and twenty years, then the expected wage is 39,900 MDL per month, 9% more than someone with ten to fifteen years of experience.
Lastly, employees with more than twenty years of professional experience get a salary of 43,200 MDL per month, 8% more than people with fifteen to twenty years of experience.
Investor Relations Officer average salary change by experience in Moldova
25 late to work excuses that may actually work! Top 10 coolest jobs that you can actually have! How to write the perfect resume (complete guide) 8 Essential CV Tips That Will Make a Huge Difference 6 simple ways for anyone to earn extra income
Investor Relations Officer Salary Comparison By Education
Displayed below is the average salary difference between different Investor Relations Officer(s) who have the same experience but different education levels.
Tweet Get Chart Linkhttp://www.salaryexplorer.com/charts/moldova/public-relations/investor-relations-officer/salary-comparison-by-education-level-monthly-moldova-investor-relations-officer.jpg
We all know that higher education equals a bigger salary, but how much more money can a degree add to your income? We broke down Investor Relations Officer salaries by education level in order to make a comparison.
When the education level is High School, the average salary of an Investor Relations Officer is 18,700 MDL per month.
While someone with a Certificate or Diploma gets a salary of 22,000 MDL per month, 18% more than someone having a High School degree.
A Bachelor's Degree gets its holder an average salary of 31,900 MDL per month, 45% more than someone with a Certificate or Diploma.
Professionals who hold a Master's Degree are rewarded with an average salary of 41,700 MDL per month, 31% more than someone with Bachelor's Degree.
Investor Relations Officer average salary difference by education level in Moldova
A Master's degree program or any post-graduate program in Moldova costs anywhere from 133,000 Moldovan Leu(s) to 400,000 Moldovan Leu(s) and lasts approximately two years. That is quite an investment.
Investor Relations Officer Salary Comparison By Gender
Tweet Get Chart Linkhttp://www.salaryexplorer.com/charts/moldova/public-relations/investor-relations-officer/salary-comparison-by-gender-monthly-moldova-investor-relations-officer.jpg
Though gender should not have an effect on pay, in reality, it does. So who gets paid more: men or women? Male Investor Relations Officer employees in Moldova earn 12% more than their female counterparts on average.
Salary Comparison By Gender in Moldova for all Careers
Tweet Get Chart Linkhttp://www.salaryexplorer.com/charts/moldova/salary-comparison-by-gender-monthly-moldova.jpg
Investor Relations Officer Average Annual Salary Increment Percentage in Moldova
How much are annual salary increments in Moldova for Investor Relations Officer(s)? How often do employees get salary raises?
Investor Relations Officer
Investor Relations Officer(s) in Moldova are likely to observe a salary increase of approximately 7% every 30 months. The national average annual increment for all professions combined is 4% granted to employees every 29 months.
Tweet Get Chart Linkhttp://www.salaryexplorer.com/charts/moldova/public-relations/investor-relations-officer/annual-salary-increment-rate-moldova-investor-relations-officer.jpg
Moldova / All Professions
"The average salary increase in one year (12 months) in Moldova is 2%."
Listed above are the average annual increase rates for each industry in Moldova for the year 2021. Companies within thriving industries tend to provide higher and more frequent raises. Exceptions do exist, but generally speaking, the situation of any company is closely related to the economic situation in the country or region. These figures tend to change frequently.
Top 10 Highest Paying Careers in Moldova
Investor Relations Officer Bonus and Incentive Rates in Moldova
Tweet Get Chart Linkhttp://www.salaryexplorer.com/charts/moldova/public-relations/investor-relations-officer/annual-salary-bonus-rate-moldova-investor-relations-officer.jpg
An Investor Relations Officer is considered to be a high bonus-based job due to the generally limited involvement in direct revenue generation, with exceptions of course. The people who get the highest bonuses are usually somehow involved in the revenue generation cycle.
Investor Relations Officer Average Hourly Wage in Moldova
170 MDL per hour
The average hourly wage (pay per hour) in Moldova is 170 MDL. This means that the average Investor Relations Officer in Moldova earns approximately 170 MDL for every worked hour.
Investor Relations Officer VS Other Jobs
Tweet Get Chart Linkhttp://www.salaryexplorer.com/charts/moldova/public-relations/investor-relations-officer/salary-comparison-between-investor-relations-officer-and-public-relations-monthly-moldova.jpg
The average salary for Investor Relations Officer is 9% more than that of Public Relations. Also, Public Relations salaries are 1% more than those of All Jobs.
Communications Associate 14,600 MDL -50%
Communications Specialist 16,200 MDL -44%
Director of Communications 39,100 MDL +34%
Government Relations Officer 26,000 MDL -11%
Head of Public Relations 42,800 MDL +47%
Investor Relations Officer 29,100 MDL -0%
Media Relations Specialist 34,100 MDL +17%
Meetings Coordinator 11,600 MDL -60%
Public Relations Manager 40,400 MDL +39%
Public Relations Officer 16,000 MDL -45%
Public Relations Practitioner 19,900 MDL -32%
Public Relations Specialist 17,100 MDL -41%
Relationship Management Officer 12,700 MDL -56%
Chisinau 30,700 MDL
Where can you get paid more, working for a private company or for the government? Public sector employees in Moldova earn 14% more than their private sector counterparts on average across all sectors.
All Jobs»Public Relations»Investor Relations Officer


With the recent midterm elections now behind us, I've been thinking a lot about competing concepts in the application of ideology. You know, the whole "principle versus pragmatism" debate.
On Nov. 2, my Libertarian Party performed about as well as expected (i.e., no one of significance was elected). It certainly makes one reassess under which umbrella one's political convictions can be best utilized. But I hate Democrats, and I just can't stomach the thought of registering Republican. I'm politically homeless; I suspect many people feel that way.
A strong ideological identity is a wonderful characteristic to expect from our elected officials. In fact, it isn't difficult to argue that many of America's problems today stem from either the inability or unwillingness of her leaders to take stands based on principle.
But that is an easy cop-out, isn't it? It doesn't take much effort to denigrate "the politicians" as being spineless, self-absorbed bastards. We hear it from our friends and neighbors almost daily.
Arrogant. Egocentric. Chameleonic. Lacking backbone. But are there any instances where political leaders suffer from too much virtue?
Suggesting it almost seems silly. Of course we want our representatives to be persons of honor. Americans like individuals of strong character. We prefer people who will act decisively and stand by their decisions.
We respect folks who "go with their gut", and yet we Americans, a sensible bunch, do have an aversion to ideological purity. There is a fine line between the two, a line I'm having trouble putting into words. But we know it when we see it. Maybe "stubbornness" or "rigidity" most accurately describes the point at which high-minded ideological purity turns into aggravating pigheadedness.
One has to deal with the consequences of this Utopian sterility as a member of the Libertarian Party. Libertarians pride themselves on being "The Party of Principle." And indeed, whether you agree with its substance or not, one must acknowledge a strong intellectual consistency inherent in the Libertarian Party platform.
I also blame this rigidity as the primary factor behind why there are no elected Libertarians in positions of political significance.
Some Libertarians simply appear unwilling to budge on practical policy application: School vouchers. Private Social Security Accounts. HSA's. All concepts that present a viable opportunity to both inject competition into failing programs and also serve as pretexts for ending the federal monopoly on personal choice and private industry. All opposed by (many) Libertarians due to cerebral whimsies.
Now, look, I get it. I'm no great fan of using public dollars to fund private religious-based education, and all the rest. This is all well and good in terms of integrity. And these intellectual debates serve a purpose.
I appreciate and admire the resoluteness with which my party avoids sacrificing ideals for the sake of political gain. I also possess no illusions about the complexities of taking away the peoples' "free stuff" by slashing the welfare state.
It is not easy to make the United States of America a better place in big, sweeping steps. Barack Obama has proved this beyond the shadow of a doubt. Society is best improved incrementally, and Libertarians can win elections when they finally get this.
Success doesn't have to come at the expense of integrity, either. That is a false dichotomy. Goals need not change for people to adopt different tactical means for reaching those goals.
I'd like to think that a successful political philosophy could be likened to a freeway. Every freeway I've traveled on has a shoulder and a center divider. Like a strong philosophical foundation, these are clearly defined lines you never cross.
But in between every shoulder and center divider, there are multiple lanes. These lanes allow for maneuverability, and exist for optimum harmony on the road. Bigger, more renowned freeways have more lanes, and thus accommodate more drivers.
We hope that drivers don't recklessly travel between lanes without first considering a multitude of factors, though some inevitably do. But the fact that they do doesn't negate the obvious benefits of a large freeway. A bustling freeway means more people, and that is a good thing in politics if you want to be successful.
The Libertarian Party is a small freeway with one lane. A shoulder and center divider occupies either side of its one-way road. When it wants to win, it will have to grow.
Iron will is not the only hindrance to its growth, of course. Republicans and Democrats agree on one thing: they like being the only two parties in power. And they have rigged the laws so it is almost impossible for third party candidates to make a difference in state and national elections.
I don't know the right way to expand it effectively, because I happen to love the Libertarian platform. All I know is there are a lot of disgruntled conservatives who are coming around to the realization that the Republican Party will not really shrink government.
And there are, thanks to President Obama, a lot of "progressives" who are coming around to the realization that the Democratic Party does not really represent freedom or peace. The LP has a chance to capitalize on their disillusionment. It will be fascinating to see if they can do that without abandoning their roots, so to speak.
Despite all my conjecture, I don't have a lot concrete answers. My thoughts are just that, and I don't want to claim final authority on these concepts. I guess I'm better at finding faults than identifying solutions. But as time goes on, I hope we can get closer to pinpointing the answers.
I think that one of the major things that hurts the Libertarian Party, at least with regard to federal offices, is its isolationist views. As I understand its position, the U.S. should bring all of its troops home, close all U.S. military bases on foreign soil and sit back and wait until the U.S. is directly threatened, and only then take action.
I think that Libertatians have a better shot at state and local offices but they seem to fail in getting their message out.
I refer to myself as a "small-L" libertarian because I'm fiscally conservative and believe in nearly absolute personal freedom. As long as you're not hurting anyone else I say do whatever you want. I believe that the Founders were "small-L" libertarians.
I think those Libertarians who really want to be successful in getting their message out should join the tea-party movement. That seems to be the best vehicle to get out the get-the-government-off-my-back message.
I found it interesting that you singled out public funding of private religious-based education as something you're not a fan of. A true Libertarian should want the government out of education entirely, just as I, the small-L one, believes.
Great opinion piece. This deserves more of a comment than I am giving it.
I'd hate to see the Libertarian Party compromise and move to the right… or the left, for that matter.
Disclaimer: I am not a LP member or a member of any party. My thoughts are too amoebic and all over the place. I agree with some/much of what you say.


text:
The Brandon Teena Story is a 1998 American documentary film directed by Susan Muska and Greta Olafsdottir. The documentary features interviews with many of the people involved with the 1993 murder of Brandon Teena as well as archive footage of Teena. After its theatrical release, it aired on Cinemax as part of its Reel Life series.

Awards
Berlin Film Festival:Teddy Award for Best Documentary
GLAAD Media Award:GLAAD Media Award for Outstanding Documentary (nominee)
Vancouver Film Festival:Best Documentary Winner

References

Further reading
All She Wanted by Aphrodite Jones, a book released in 1996 about the murder.

External links

 The Brandon Teena Story at Bless Bless Productions

Transgender-related documentary films
1998 LGBT-related films
1998 films
American documentary films
1998 documentary films
American LGBT-related films
Documentary films about violence against LGBT people
Films about trans men
Documentary films about Nebraska
Biographical films about LGBT people
1990s English-language films
1990s American films

redpajama_set_name: RedPajamaWikipedia


text:
4 Penny Stocks To Watch With Big News In December 2022
Penny stocks to watch this week.
Best Penny Stocks To Buy? 7 Under $1 To Watch Now
Published on December 6, 2022, 11:15 America/New_York
BNGO,
BNGO stock,
GERN,
GERN stock,
GRIL stock,
NEWT,
VGFC,
VGFC stock
Hot Penny Stocks To Watch With The Stock Market Down Today
The stock market is down today, but that doesn't mean all stocks are getting dumped. In fact, in this article, we discuss a handful of bullish names trading higher in a sea of red. What's helping them stay afloat? Big news has become a significant catalyst acting as a buoy. Not only that, this list of penny stocks isn't just maintaining, they accelerated higher during Tuesday's morning session.
How To Find Penny Stocks For Your Watch List
It can be challenging, at times, to find penny stocks to buy, let alone ones to add to your watch list. But the thing to remember is even when the stock market sells off; there are usually a few cheap stocks to watch for one reason or another. Thanks to the more speculative nature of this low-price environment, even when most companies' shares are down, penny stocks tend to be resilient, even if it's just for a single session.
Whether it's short squeeze stocks, insider trading activity, unusual options, or simply a bullish momentum surge, you've got your pick as far as deciding what trends to look for. The most important part is picking penny stocks that you can add to your list based on your personal trading strategy.
For instance, if you're a swing trader, stocks moving up and down rapidly within minutes are probably not for you. Then again, if you are looking for quick scalps in the market, slow-moving stocks wouldn't necessarily meet your criteria. In the stock market today, bears are taking control early, which has made it a bit more challenging to find bullish opportunities.
– 4 Hot Penny Stocks To Watch Before Next Week
Why Is The Stock Market Down?
What may help clear out some of the noise is understanding why the stock market is down in the first place. Monday's stock market sell-off continued on Tuesday. This was thanks, in part, to early comments made by JPMorgan CEO Jamie Dimon saying a mild to hard recession could hit next year.
Semiconductor stocks also helped drag down tech, but the main story and focus of the day remain the Federal Reserve. Signs of strength in the U.S. economy continue spooking investors who have hoped Fed rate hikes would begin easing. The latest employment data is thought to be a compelling argument that monetary policy still has room for hawkish action.
We're in a blackout period for Fed members, and that has allowed imagination to run wild. According to the Federal Reserve, "The blackout period will begin at the start of the second Saturday (midnight) Eastern Time before the beginning of the meeting and will end at midnight Eastern Time on the next day after the meeting. For example, if the Committee meeting starts on a Tuesday, the blackout period will begin at the start of the Saturday that falls ten days earlier, and if the meeting ends on a Wednesday, the blackout period will end at the end of Thursday."
Without additional commentary, the market is going off the last round of economic data. Meanwhile, investors await one of the most important CPI reports of the year that comes next week and one day before the conclusion of the final FOMC meeting of the year.
Penny Stocks To Watch
Geron Corp. (GERN)
Anyone looking for some of the most consistent, high-performing penny stocks of 2022 might have GERN stock on their list. That's because shares have climbed from lows of under $1 in February to above $3 in September. Now, in December, the penny stock is still trading well above the $2 level as the company continues hitting milestones.
Geron is a clinical biotech company focused on advancing its imetelstat platform. There is two Phase 3 trials underway evaluating the treatment in lower-risk myelodysplastic syndromes and relapsed/refractory myelofibrosis.
A few upcoming events could have sparked speculation-fueled momentum in the stock market this week. The first is a few presentations set to take place at next week's American Society of Hematology meeting. The next comes in January, where Geron hopes to report top-line results from its ongoing Phase 3 IMerge trial of imetelstat designed to confirm Phase 2 data.
"The upcoming presentation at ASH of the longer-term follow-up data from our Phase 2 IMerge trial showing unprecedented greater than one-year continuous transfusion independence in approximately one-third of the 38 lower-risk MDS patients in the study highlights the differentiating qualities of imetelstat that could address significant unmet needs in this indication," said Faye Feller, M.D., Executive Vice President, Chief Medical Officer of Gero in a November update.
With these upcoming events, GERN stock could be one of the names to watch heading into the new year.
Muscle Maker Inc. (GRIL)
We discussed Muscle Maker Inc. earlier this month. In the article, Penny Stocks To Buy: 6 Insider Picks Before December 2022, we highlighted GRIL stock with insider activity in mind. The company's CEO, CIO, COO, and CFO purchased shares of the penny stock, according to filings, between 11/23 and 11/25.
Muscle Maker recently launched a new project with Aggia, a UAE company, to have it operate the new Muscle Maker subsidiary, Sadot LLC. This new subsidiary will source, distribute, and produce agricultural goods, such as shipping grains via cargo ship. In addition, the Pokemoto brand inked a partnership with Newtek Business Services (NASDAQ: NEWT) to secure funding for opening new locations in the US.
This week, Pokemoto is back in focus again. The brand crossed the 50 franchise agreement milestone and now reaches 15 states once all are opened. "Seeing our footprint grow shows that our franchise marketing efforts are working and that we're resonating with the right audiences. We continue to seek out new partnerships, vendors, and resources to expand our tool kit for prospective and current franchisees so that they can focus their efforts on expanding their Pokemoto portfolios," said Pokemoto CEO Michael Roper in this week's update.
Considering the latest round of achievements and insider activity, GRIL stock has been one to watch over the last few weeks. Keep in mind, however, that the run-up has been quick. Shares are trading above $0.75 this week compared to around $0.40 at the start of last week. Will profit-taking become a factor, or will the penny stock continue moving higher? That's something to be seen but worth noting if GRIL stock is on your watch list.
– Tips for Buying Penny Stocks Under $3 Right Now
Bionano Genomics (BNGO)
Shares of Bionano Genomics have caught a nice surge in momentum this month. The move comes as BNGO shares hold a relatively sideways trend as the overall markets pull back. Bionano specializes in genome analysis solutions for researchers and clinicians. It offers different solutions for applications in translational and clinical research.
Bionano's Lineagen Inc (Bionano Laboratories) also provides diagnostic testing. These testing solutions are for patients with indications of autism spectrum disorder and neurodevelopmental disabilities. The company has also expanded its footprint to include other areas of genome analysis and testing, which is what may be in focus this week.
Bionano announced in November that it planned to acquire Purigen Biosystems. The deal would allow the company to simplify further and speed up its DNA isolation in optical genome mapping. It also adds a proprietary technology licensed by Purigen called isotachophoresis (ITP) and Purigen's Ionic Purification System for isolating DNA and RNA from biological samples.
Science aside, this acquisition is valued at up to $64 million, with a cash payment of $32 million at closing. The closing date is what could be the catalyst right now. According to the November release, the acquisition is expected to close "on or before December 8, 2022."
Since the date is this week, BNGO stock could be one of the names to watch.
The Very Good Food Company (VGFC)
Penny stocks under $1 have become a popular trend among retail traders. It is one of the most frequently searched for on our site. That makes sense based on how volatile the market has been and how traders have focused on capitalizing on quick moves instead of making long-term investments.
Stocks under $1 don't require much to produce significant percentage moves. The lower the price, the higher the volatility in general. The Very Good Food Company is among the lowest-priced names on the list and was one we discussed in our article, "3 Hot Penny Stocks to Buy For Under 10 Cents."
Since then, VGFC stock managed to bounce as high as $0.16, and though it was only a few cents, it equated to a jump of more than 50%. This week, shares are back on the move as traders remain focused on its latest partnership with Albertsons grocery stores. Starting next year, Albertsons' will offer products in the freezer sections of 7 divisions, roughly 900 stores.
List Of Penny Stocks To Watch This Week
Geron Corp. (NASDAQ:GERN)
Muscle Maker Inc. (NASDAQ:GRIL)
Bionano Genomics (NASDAQ:BNGO)
The Very Good Food Company (NASDAQ:VGFC)
3 Must Watch Penny Stocks For Your May 2022 List
Here are three penny stocks to add to your watchlist
Best Penny Stocks To Buy Next Week? 5 Biotechs You Might've Missed
Are These Biotech Penny Stocks On Next Week's Watch List?
3 Penny Stocks To Watch With "Strong Buy" Ratings
Are These On Your Penny Stocks Watch List In 2020? I'm sure…
Penny Stocks To Watch For April 2021 If You Like Biotech
Hot Biotech Penny Stocks For April 2021's Watch List


text:
Q: Flutter use plugin based on platform (compile time optimization) I want to use android_alarm_manager for the android side and work_manager for the ios. Is there any way to tell flutter NOT to include work_manager for the android build?
Note: I am asking for a solution for compile-time optimization which checking platform.isAndroid can not do.

A: There is no way to include only part of a plugin.

*

*If you are only concerned with the native part of the plugin, you could fork it (even just locally) and remove the android entry from the plugin's pubspec.yaml, then use your fork.

*If you are also concerned about the Dart code, you would need to:

*

*extract most of the logic to a package

*define an abstraction for the functionality you want to implement with the two plugins

*make the shared logic package take that abstraction via injection

*make two app projects, one for Android and one for iOS, each using the shared package, and each including the relevant plugin and providing an implementation for the abstraction using that plugin


text:
Q: GNU Auto completion on variables I'm developing a Linux tool with a prompt in C. I have enabled "function" and "file" completion using GNU library. Now I want to extend the support to "variable" name completion as well. Below is the example for better understanding:
WORKING OUTPUT:
build2:/u/anitha> linux_tool
loading history
tool>
tool> ***On pressing TAB twice, the functions are prompted***
Display all 251 possibilities? (y or n)
byte(
dim(
fncc_fft2d(
HasValue(
ifft(
load_csv(

EXPECTED ADDITIONAL SUPPORT:
tool> **var_name**=create(2,2)
2x2x1 array of int, bsq format [16 bytes]
0       1
2       3
tool>
tool> ***on pressing TAB twice, I want the variable name to be prompted for auto completion. i.e.**,*
tool> var_
**var_name**
Version(

Code added for auto completion:
char ** dv_complete_func(char *text, int start, int end);
char *dv_complete_func_generator(const char*, int);
extern struct _vfuncptr vfunclist[];
  /* This array has the list of functions that the tool can support */

char **
dv_complete_func(char *text, int start, int end)
{
  return rl_completion_matches(text, dv_complete_func_generator);
}

char *dv_complete_func_generator(const char *text, int state)
{
    static int list_index, len;
    char *name;

    if(!state) {
        list_index =0;
        len=strlen(text);
    }

    while((name = vfunclist[list_index++].name)) {
        if(strncmp(name,text,len)==0) {
             char *namedup = strdup(name);
             strcat(namedup,"(");
            return strdup(namedup);
        }

    }
    return NULL;
}

Let me know if the question is unclear. Please help me with a solution.

A: (Just a guess, since you don't show your function bound to rl_attempted_completion_function as you really should)
You probably should also use the rl_line_buffer, rl_point , rl_end global variables (modified by readline, you want only read access to them).
Read carefully (and several times) the chapter on custom completers.
BTW, you almost certainly should use start  and end  arguments to dv_complete_func  (assuming you put that in rl_attempted_completion_function)
NB. I did experiment around these ideas in my (defunct) minil project on github. Sadly all comments and variables there are in French (because it was written to convince a French retired AI researcher). And yes, readline API is very baroque (and you also should study the source code of programs using it, notably GNU bash). Maybe you should consider using some other library... (look into ncurses and see this question and other libraries)


Flannel's W19 Essentials feature a unique pop of colour this season. Bright Coral hues, and rich Copper are spliced in with our favourite achromatic tones, Black and Natural. Flannel's highly coveted Essential Slip is cut on the bias, perfectly flattering the female form with a subtle v-neck.


text:
Ex-DEA agent sentenced to one year in prison for indecent proposal
Friday, October 15th 1999, 12:00 am
A Comanche County judge has sentenced a
former Drug Enforcement Administration agent to one year in prison for making an indecent proposal to a teen-ager.
Kevin Dewayne Waters was convicted Aug. 25 in connection with a May 9, 1998, incident in which he is alleged to have used the
Internet to solicit sex with a teen-age Lawton girl.
Oklahoma City police officers and retired DEA agents wrote letters in support of Waters, an Edmond resident, and out of concern for his well-being if he were imprisoned.
Waters' attorney, J.W. Coyle III, asked for a suspended sentence and counseling for his client, but District Judge Mark Smith chose
the prison term.
Assistant District Attorney Bill Riley had asked
the court to follow the jury's recommendation.
Coyle indicated he would appeal.
Waters was arrested in a Lawton shopping mall after he agreed to meet the girl to whom he allegedly made an indecent proposal to in
an Internet chat room.
Police searched his home in Edmond after his arrest and seized his computer and photos of children having sex with adults.
Waters' employment has been officially terminated, said Julio Mercado, DEA special agent in charge of the Dallas field division,
which includes northern Texas and Oklahoma.
He had been with the agency since August 1988.
News On 6 A Comanche County judge has sentenced a
Kevin Dewayne Waters was convicted


2013 CRF250 Engine Bolt Kit. The kit contains the following parts. If you wish you can purchase the parts individually from this website. 2ea SHHFM610A4 Valve Cover, 2ea TLNUTM8-12 Exhaust Flange, 1ea T4HFM6-10X20 Coolant to Head, 3ea T4HFM6-10X25 Head & Cylinder side Mounts, 1ea LFM610G10 Cam Chain Tensioner, 2ea T4HFM6-10X15 Cam Chain Tensioner, 1ea T4HFM6-10X20 Ignition Coil, 1ea T4HFM6-10X15 Oil Filter Cover, 1ea T4HFM6-10X75 Oil Filter Cover, 8ea T4HFM6-10X30 Stator Cover, 1ea T4HFM6-10X40 Stator Cover, 1ea T4HFM6-10X15 Clutch Cable Guide, 3ea T4HFM6-10X45 Centercase, 2ea T4HFM6-10X50 Centercase, 2ea T4HFM6-10X55 Centercase, 7ea T4HFM6-10X70 Centercase, 2ea T4HFM6-10X15 Regulator/Rectifier mounts, 2ea TLNUTM6-10 Regulator/Rectifier Mount nuts, 2ea T4HFM6-10X20 Regulator/Rectifier Mounting Plate, 1ea T6M8-12X33F Counter Sprocket, 2ea T4HFM6-10X30 Countershaft Cover, 1ea T4HFM6-10X20 Shifter, 1ea CR ClUTCHHUB Clutch Hub Nut, 1ea M12HFA Primary Gear Bolt On Crank, 8ea T4HFM610X25 Right Sidecase, 2ea T4HFM6-10X35 Right Sidecase, 1ea LFM610G10 Oil Check Bolt, 5ea T4HFM6-10X20 Clutch Cover, 1ea T4HFM6-10X60 Clutch Cover, 1ea T4HFM8-12X70 Side Oil Drain, 1ea T4HFM8-12X20 Bottom Oil Drain, 1ea LGHFM81213-1 Kickstarter, 1ea FHM6-10X20 Kickatarter, 3ea T4HFM6-10X25 Waterpump Cover, 1ea T4HFM6-10X65 Waterpump Cover.


text:
Q: Rasa crashes when a message is sent I have installed Rasa without any errors. When I run rasa shell the server is started and I am presented with the chatbot prompt. when I enter hi I get the following error:
Bot loaded. Type a message and press enter (use '/stop' to exit):
Your input ->  hi
Exception occurred while handling uri: 'http://localhost:5005/webhooks/rest/webhook?stream=true&token='
Traceback (most recent call last):
  File "g:\programs\python\python37\lib\site-packages\sanic\app.py", line 946, in handle_request
    request, request_name=name
TypeError: _run_request_middleware() got an unexpected keyword argument 'request_name'
Exception occurred in one of response middleware handlers
Traceback (most recent call last):
  File "g:\programs\python\python37\lib\site-packages\sanic\app.py", line 1017, in handle_request
    request, response, request_name=name
TypeError: _run_response_middleware() got an unexpected keyword argument 'request_name'
2020-01-04 11:29:30 ERROR    asyncio  - Task exception was never retrieved
future: <Task finished coro=<configure_app.<locals>.run_cmdline_io() done, defined at g:\programs\python\python37\lib\site-packages\rasa\core\run.py:124> exception=ClientResponseError(RequestInfo(url=URL('http://localhost:5005/webhooks/rest/webhook?stream=true&token='), method='POST', headers=<CIMultiDictProxy('Host': 'localhost:5005', 'Accept': '*/*', 'Accept-Encoding': 'gzip, deflate', 'User-Agent': 'Python/3.7 aiohttp/3.6.2', 'Content-Length': '38', 'Content-Type': 'application/json')>, real_url=URL('http://localhost:5005/webhooks/rest/webhook?stream=true&token=')), (), status=500, message='Internal Server Error', headers=<CIMultiDictProxy('Connection': 'keep-alive', 'Keep-Alive': '5', 'Content-Length': '144', 'Content-Type': 'text/html; charset=utf-8')>)>
Traceback (most recent call last):
  File "g:\programs\python\python37\lib\site-packages\rasa\core\run.py", line 128, in run_cmdline_io
    server_url=constants.DEFAULT_SERVER_FORMAT.format("http", port)
  File "g:\programs\python\python37\lib\site-packages\rasa\core\channels\console.py", line 140, in record_messages
    async for response in bot_responses:
  File "g:\programs\python\python37\lib\site-packages\rasa\core\channels\console.py", line 104, in send_message_receive_stream
    async with session.post(url, json=payload, raise_for_status=True) as resp:
  File "g:\programs\python\python37\lib\site-packages\aiohttp\client.py", line 1012, in __aenter__
    self._resp = await self._coro
  File "g:\programs\python\python37\lib\site-packages\aiohttp\client.py", line 588, in _request
    resp.raise_for_status()
  File "g:\programs\python\python37\lib\site-packages\aiohttp\client_reqrep.py", line 946, in raise_for_status
    headers=self.headers)
aiohttp.client_exceptions.ClientResponseError: 500, message='Internal Server Error', url=URL('http://localhost:5005/webhooks/rest/webhook?stream=true&token=')

I have had no issues installing an since I am new to Rasa I am not sure what the problem is.
Please advise.
Thanks

A: Check your sanic version it may not match the requirements.
Has to be 19.9.0
Run this to install the right version:

pip install sanic==19.9.0


text:
What is the main Filipino language?
What is Filipino language?
Do all Filipino speak English?
Is Filipino a nationality?
Who speaks Filipino?
What is Filipino race?
Is Filipino Hispanic?
1. a native or inhabitant of the Philippines. 2. Also called: Pilipino. a language essentially the same as Tagalog that has been adopted as the official national language of the Philippines.
Most educated Filipinos are bilinguals and speak English as one of their languages. … Because English is part of the curricula from primary to secondary education, many Filipinos write and speak in fluent Philippine English, although there might be differences in pronunciation.
Filipinos of mixed ethnic origins are still referred to today as mestizos. However, in common parlance, mestizos are only used to refer to Filipinos mixed with Spanish or any other European ancestry.
Social classifications.
Insulares/Filipino person of purely Spanish descent born in the Philippines
Filipino language
Native to Philippines
Native speakers 45 million L2 users (Tagalog) (2013)
Language family Austronesian Malayo-Polynesian Philippine Central Philippine Tagalog Filipino
Writing system Latin (Filipino alphabet) Philippine Braille Baybayin
The majority of the people in the Philippines are of Austronesian descent who migrated from Taiwan during the Iron Age. They are called ethnic Filipinos. The largest Filipino ethnic groups include the Tagalog, Cebuano, Ilocano, Bicolano, Kapampangan, Maranao, Maguindanao, and Tausug.
In fact, since Hispanic is conventionally defined as an ethnic category (Lowry 1980, Levin & Farley 1982, Nagel 1994) while Filipino is officially a category of race (Hirschman, Alba & Farley 2000), the intersecting identities of Hispanic Filipinos appear alongside other groups such as Punjabi or Japanese Mexican …
THIS IS AMAZING: Where can I buy gold bars in Singapore?


text:
Capac's Early Railroad Depots
In 1870 the Port Huron and Lake Michigan Railroad Company, later the Grand Truck Railroad, opened a rail line and depot in Capac. Judge Dewitt C. Walker, Capac's founder later recalled that the "shrill noise of the locomotive whistle that first rang out upon the frozen air and re-echoed through the trees that surrounded the village...heralded the advent of prosperity for this place." Such local goods as timber, barrel staves and grain were shipped on the railroad, helping spur the village's growth. The first depot, built north of the tracks, burned down in 1880, and a second, brick depot was built south of the tracks. It was declared "unsafe" and replaced by a third depot north of the tracks in the 1890s.
The Fourth Capac Depot
After Capac's third railroad depot was destroyed by fire on January 9, 1914, the Grand Trunk Railroad Company constructed this station. Located north of the tracks, just south of Railroad Street, it opened on October 17, 1914. Of board and batten construction, it featured a telegraph office that brought the latest news to the village. The depot closed on October 8, 1973. The Capac Community Historical Society purchased it in 1987 for one dollar on the condition it relocate the building. In 1988 the society moved the depot in two parts to this site, about three-fourths of a mile northeast of its original location and rehabilitated the station reuse as a museum. The depot reopened as the Capac Community Historical Museum in 1994.
Location: Old M-21
Capac, Saint Clair County


text:
Summary | Understanding CKD and SGLT2-inhibition: what are the key mechanisms?
May 25, 2018 - Prof. Per-Henrik Groop
Prof. Groop set out to explain the mechanisms and outcomes of SGLT2 inhibition. First, he started with a few words on the consequences of CKD. Prof. Groop: 'The consequences of CKD are grim. Data from many trials and observational studies show a many-fold increased risk of premature mortality in T2DM patients with albuminuria and/or impaired eGFR, which is due to CVD [7]. Every T2DM patient with CKD has a doubled risk of myocardial infarction, stroke, peripheral vascular disease and premature death [8] due to risk factors that come with CKD, such as hypertension, oxidative stress, insulin resistance, arterial calcification, inflammation, left ventricle hypertrophy, endothelial dysfunction, activation of the reno-angiotensin-aldosterone system, activation of the sympathetic nervous system, anemia etc. Without doubt, CKD and CVD go hand in hand'.
Next, Prof. Groop shared renal outcome findings from the EMPA-REG OUTCOME trial and the CANVAS Program . The CANVAS program evaluated another SGLT2 inhibitor, canagliflozin. As prof. Wanner had already mentioned, the EMPA-REG OUTCOME trial demonstrated a 39% reduction in new onset or worsening of CKD in patients who were exposed to either 10 or 25 mg empagliflozin compared to placebo on top of standard care. Also, the composite endpoint of doubling of serum creatinine level, initiation of renal replacement therapy or death due to renal disease was reduced with 46% and a 55% decrease in the likelihood of ending on dialysis was observed after treatment with empagliflozin. Besides, empagliflozin-treated patients showed an initial drop in the eGFR followed by preservation of kidney function, which was not observed in the placebo group [4].
The CANVAS Program, which included low renal risk patients, showed a very similar effect of 40% reduction in the composite endpoint of eGFR, end stage renal disease or renal death. Again, an initial drop in eGFR was found, followed by normalization and preservation of kidney function. Summarized, these two big outcome trials demonstrated renal benefits in patients with T2DM after treatment with SGLT2 inhibitors [9].
The next question was: 'Why do SGLT2 inhibitors work so well?'. Although SGLT2 inhibitors are not indicated for use in patient with type 1 diabetes (T1DM), we can learn a lot about SGLT2 inhibitors from a T1DM study. One study showed a reduction of the eGFR by 33 ml/min/1.73m2 in hyperfiltering T1DM patients after treatment with empagliflozin [10]. Hyperfiltering T1DM patients have glomerular hypertension and increased intra-glomerular pressure. T1DM patients with normal filtering did not show any effect on renal function measures after treatment with 25 mg empagliflozin. This drug did, however, reduce both the intra-glomerular pressure and the eGFR in hyperfiltering T1DM patients [11]. This was accompanied by a decrease in renal blood flow and an increase in renal vascular resistance, which is consistent with an increased tone in the afferent arteriole [10].
The renal effects of the SGLT2 inhibitors can be explained by the tubular hypothesis. Normally, the SGLT2 transporter in the proximal tubule absorbs glucose and sodium, which is a balanced process. Residual sodium reaches the macula densa next to the glomerulosa, where it is absorbed again by another counter-transporter that transports sodium, potassium and chloride. Absorption of sodium requires energy, which is generated from ATP. During ATP hydrolysis, adenosine is generated, which is a basal constrictor of the afferent arteriole.
Hyperfiltering T2DM and T1DM patients with established CKD show an exaggerated reabsorption of glucose and sodium in the proximal tubule, into the blood. In this case sodium does not reach the macula densa and consequently there is no vasoconstriction in the afferent arteriole, but instead vasodilation. SGLT2 inhibitors block the sodium reabsorption, and consequently sodium reaches the macula densa again. This allows adenosine to be generated, causing vasoconstriction [12]. Prof. Groop emphasized the effect of empagliflozin on glomerular hyperfiltration by displaying a diagram that shows a similar effect of ACE inhibitors (decrease of 35 mL/min versus 33 mL/min respectively) [13][10].
Hypoxia also seems to play a role, which he illustrated with observations in experimental studies. In diabetic mice, renal hypoxia, increased eGFR and a slight increase in proteinuria were observed within three days after diabetes induction [14]. Moreover, hypoxia was not only seen in the cortex, but also in the medulla of the kidneys. After administration of dinitrophenol, a mitochondrial uncoupler, increased proteinuria, kidney vimentin expression and infiltration of inflammatory cells were observed, which is similar to the phenotype of diabetes, obesity and hypertension [15].
According to the tubular hypothesis and results in diabetic mice, prof. Groop hypothesized: 'Due to administration of a SGLT2 inhibitor there is less sodium handling, leading to reduced oxygen consumption and hypoxia, which in the end results in renal benefit'.
In summary, CKD is a common complication with grim consequences. SGLT2 inhibitors have been shown to result in CV protection and renal protective effects, beyond their effects on glucose control. However, the renal protective effects have to be studied in dedicated renal trials in the future.
4. Wanner C et al., N Engl J Med, 2016. 375(4): p. 323-34.
7. Afkarian M et al., J Am Soc Nephrol, 2013. 24(2): p. 302-8.
8. Foley RN et al., J Am Soc Nephrol, 2005. 16(2): p. 489-95.
9. 53rd Annual Meeting of the European Association for the study Diabetes; 15 September 2017; Lisbon, Portugal.
10. Cherney DZ et al., Circulation, 2014. 129(5): p. 587-97.
11. Skrtić M et al., Diabetologia, 2014. 57(12): p. 2599-602.
12. Heerspink HJ et al., Circulation, 2016. 134(10): p. 752-72.
13. Sochett EB et al., J Am Soc Nephrol, 2006. 17(6): p. 1703-9.
14. Franzén S et al., Am J Physiol Renal Physiol, 2016. 310(9): p. F807-9.
15. Friederich-Persson M et al., Hypertension, 2013. 62(5): p. 914-9.
This is a summary of the presentation given by prof. Groop, during the PACE symposium entitled 'Diabetic Kidney Disease: Exploring mechanisms and outcomes of SGLT2 inhibition', held during ERA-EDTA in Copenhagen, Denmark, on May 25, 2018
View lectures of this symposium


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Spain slaps fresh fine on food delivery firm Glovo
Spain's labour ministry said Tuesday it has slapped app-based food delivery company Glovo with a new fine of €57 million for violating labour laws.
Spain slaps fresh fine on food delivery firm Glovo. Photo: JAVIER SORIANO / AFP
Glovo, which belongs to German firm Delivery Hero, was fined for not giving its riders formal labour contracts as required under a 2021 law and for giving gigs to nearly 800 irregular immigrants without work permits, a ministry spokesman said.
Under the so-called Rider Law that came into effect in August 2021, couriers who deliver food, mostly on bicycles and motorcycles, must be recognised as employees instead of being considered self-employed freelancers as before.
It is the first European legislation that explicitly regulates the status of delivery workers, who get around on bikes and motorcycles and whose numbers have exploded in recent years, despite precarious working conditions.
"No company, no matter how big or small, should remain outside the law," Labour Minister Yolanda Díaz told reporters.
Last year the labour ministry hit Glovo with a fine of €79 million for infringements of the Rider Law.
Glovo said it would appeal the latest fine. It argues the infringements cited by the labour ministry took place before the Rider Law came into force.
Your questions answered about Spain's digital nomad visa
REVEALED: Everything you need to know about applying for Spain's digital nomad visa
Spain's long-awaited digital nomad visa is finally available, but there is still much confusion about it, so we've answered all your burning questions.
Spain's Startups Law, which also introduced a new digital nomad visa, was approved at the end of 2022, but didn't come into force until January 2023 and all the details are only just now being revealed.
From how much money you need to your tax obligations and if you can bring family, members, here are all your questions answered.
READ ALSO – REVEALED: Everything you need to know about applying for Spain's digital nomad visa
What are the financial requirements to apply for the visa?
You must prove that you earn 200 percent of the SMI or Minimum Interprofessional Salary. The current minimum wage in Spain is €1,000 per month (across 14 payments) or €1,166.67 across 12 payments.
Keep in mind though that the minimum wage is currently being re-evaluated and is likely to go up to €1,082 (across 14 payments) per month in the near future.
This means that currently, you must be able to show that you will have an income of at least €2,333.34 per month or €28,000 per year, but it is likely this will increase. You can prove this amount either with job contracts, invoices or bank statements.
Can I bring family members with me on the visa?
Yes, you are permitted to bring partners and children with you to Spain on the digital nomad visa.
In order to add a family member, however, you must prove that you have an extra 75 percent of the SMI or minimum wage. This currently equates to an extra €875. For each additional family member after this, such as children, you will have to prove you have an extra 25 percent of the SMI, currently €291.66.
READ ALSO: Ten of the best cities for digital nomads to move to in Spain
Do I need private health care?
You must also make sure that you have either private or public health insurance, simply getting travel insurance with health coverage is not enough.
The Spanish government mentions the option of getting public health insurance instead of private cover, but it is not yet clear whether this means that you will have to contribute to the social security system or be eligible for the convenio especial – the public pay-in scheme.
Do I have to have any professional qualifications?
You must prove that you either have professional qualifications or a degree relating to your job or that you have at least 3 years' experience working in your field.
How long is the visa valid for?
The visa will be valid for an initial period of one year, however, it can be renewed for up to five years. After that, if you want to continue living in Spain, you will be able to apply for permanent residency.
Does the visa give me access to travel around the EU?
Yes, once you have your visa and you're in Spain, you will be able to apply for a residency card. This will allow you to travel throughout the EU during the time that you're living in Spain.
Keep in mind though, it won't give you the right to work or live in other EU countries, but you will be able to go for short breaks.
How long do I have to stay in Spain for the visa to be valid?
Many digital nomads choose to split their time between different countries. If this is your case, and you want to split your time between back home in the US or the UK for example, you must make sure you stay in Spain for a maximum of 6 months per year for your visa to remain valid.
Do I have to pay tax in Spain?
Yes. If you stay longer than 183 days, then you will be considered a tax resident in Spain. This means that any money you earn while working in Spain, even if it comes from clients or companies abroad will be taxable.
However, the digital nomad visa grants you tax benefits, such as being able to pay the Non-Residents Tax Rate (IRNR) rather than the regular progressive income tax (IRPF) that Spain's resident workers pay.
Non-Resident Tax was previously only applicable to non-residents such as second-home owners, but an exception has been made for digital nomad visa holders even if they spend more than 183 days a year in Spain and are therefore technically fiscal residents.
IRNR is generally 24 percent in Spain and digital nomads will be able to pay this instead of the more progressive rates, as long as they earn below €600,000 a year.
This favourable tax rate will be available for four years, if you choose to renew your visa.
Everything you need to know if you lose your job in Spain
Everything that changes for self-employed people in Spain this year


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Sepp Called Up To Netherlands U21s
Sepp van den Berg has received his first call up to the Netherlands U21 national side.
The on-loan Liverpool defender has previously featured for their U19 side, making ten appearances in that age group, but will now make the step up to the level just below the seniors.
19-year-old Sepp and his team-mates will begin their qualifying campaign for the 2023 European Championships on Tuesday 7th September as they take on Moldova, kicking off at 5.45pm.
That will be their only game of this international break, with a double-header against Switzerland and Wales coming in October.
Best of luck during the break, Sepp!


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Media Log's three rules for reporting on extramarital affairs. After the Kerry sex-scandal non-story imploded, Matt Drudge hit what might have been a new low even for him. On Monday, the Drudge Report alleged that the young woman who did not have sex with Kerry may have had sex with a veteran Kerry-campaign operative.
Thus we have a new sex story that may or may not be true - complete with names! - about two entirely private figures. Other than the vicarious thrill Drudge apparently receives from destroying two families, it is impossible to imagine why anyone would do such a thing. As my late father liked to say, it's enough to gag a maggot.
Garbage like this is going to come up again. So with that in mind, I would like to offer Media Log's rules for reporting on the sex lives of presidential candidates. Conveniently enough, I learned them from eight years of watching Bill Clinton, who, unfortunately for him, ran afoul of all three rules. To wit:
The Gennifer Flowers Rule. If an ex-paramour calls a news conference in order to talk about her affair with The Candidate, it's okay to cover it, provided - in the absence of proof - that the allegations are treated with suitable skepticism. Public events are public events, and it would be an abuse of the media's gatekeeper role to pretend they didn't occur. Nor should the entertainment factor be overlooked.
The Paula Jones Rule. If a woman files a lawsuit that alleges The Candidate harassed her by soliciting a blowjob, it's okay to cover it - again with suitable skepticism. If said lawsuit makes it all the way to the Supreme Court, it's definitely okay to cover it. If said lawsuit further alleges that the plaintiff can identify "distinguishing characteristics" on the defendant's unit, then coverage is mandatory.
The Monica Lewinsky Rule. If a $40 million (at the time) government investigation reveals that The Candidate (or, in this case, the president) was carrying on with a woman other than his wife, and that his lies about said carrying-on may constitute perjury in the context of a sexual-harassment suit (see the Paula Jones Rule, above), then it's okay to cover it. It's not okay to go berserk for six months, leading to a stampede that resulted in the only presidential impeachment in the 20th century. (Note: Media Log confesses to breaking the don't-go-berserk rule on several occasions.)
There's a gray area here, too. Occasionally, there will be a candidate - like Gary Hart in 1988 - who essentially says, I've got nothing to hide. Please follow me around and report on what you find! Of course, someone did, and Hart's presidential ambitions went down on the Good Ship Monkey Business.
The answer: damned if I know what the media should have done. Hart was stupid, and stupidity is always worth reporting on. Still, affairs between two consenting adults should always be off limits unless one of the Clinton rules comes into play. My best answer is to hope that someone else reports it, then write a thumb-sucking think piece about the decline of media standards.
Censorship, plainly defined. Need any more proof ...
An interesting wrinkle on gay marriage. Maybe I'm...
Kerry's not-so-gay moment. If an amendment to the...
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Measuring the Buchanan effect. Boston Globe colum...
Civil unions for everyone. The results of the lat...
Tom Oliphant responds. The Boston Globe columnist...
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Unoriginal sin "Howard's End" - New Yor...
Rule number four. John Doherty, co-creator of the...
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Joe Conason's non-hypocritical Spy piece. Media L...
The sliming of Max Cleland, cont'd. As I noted o...
Good job, Matt! The sliming that's going on right...
If Bill Gates did this, people would be howling. ...
Like Bush said about Adam Clymer, only minor-leag...
There is less joy in Mudville. Some counterintuit...
A non-sex non-scandal non-story. There is only on...
ConCom continuing coverage at BostonPhoenix.com. ...
Finneran to the rescue? It looks like the best ho...
The seductive appeal of mob rule. There is no mor...
Winning by losing. Jay Rosen is among the more th...
Kerry takes a stand (sort of). The great thing ab...
Jay Severin's rotten mouth. I can't imagine there...
Homework help for John Kerry. As a public service...
Not answering the real question. As the Boston Ph...
Clear language, vague pols. Anyone who took the t...
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Kerry and the lobbyists. In case you missed it, h...


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Re-visiting this paper has had me reviewing my thoughts on Satoshi's comments in regard to Mises Regression theorem. Satoshi jumped straight past the implication that bitcoin contends with the theorem and instead commented on how an otherwise dull and useless gold, with unsurpassable transport properties, might likely be picked up as a money if there were no other alternatives available-regardless if it had an alternative (non money) use case or established price.
This is interesting to consider if we know that bitcoin's early codebase had poker software "baked" into it as if Satoshi was trying to establish an initial use case but eventually abandoned the pursuit when realizing such a pursuit is not really necessary.
I sometimes then see bitcoin as properly treated academic experiment where the authors were able to stay removed from the perception of the results by other observers and to actually craft an implementation of the idea that was eventually launched.
I think at that time we will then inquire into the nature of our valuation of gold and that we will eventually see that as much as we valued gold for its initially observable properties (ie shiny but we probably didn't know it was a superconductor when it was first discovered) we learned to value its properties when we brought it to the forefront of our attention because of its monetary usefulness (ie rather than its aesthetic applications).


Our aim is to finance our activities through a broad range of funding bodies to ensure we remain independent and to support long term sustainability. During an average twelve months we deliver services to around 4500 people and we could help so many more if we had additional funds.
Companies can sponsor Onside in a number of ways and show their own support for disadvantaged and vulnerable people in our community. Sponsorship can be in the form of cash donations, goods or services.
Onside has been working to support vulnerable and disadvantaged adults since 1993, in an average year we work with around 2000 people who face a number of challenges in their lives from bereavement and old age to disability and mental ill health.
We provide support through paid staff and dedicated volunteers. We couldn't do this without donations. An important way that you can support Onside to continue its work is by leaving a legacy in your will, this could be a simple cash payment or a percentage of the residual estate.


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The Fourth Judicial Circuit Court of Illinois
The Court System
Judges and Associate Judges
Illinois Courts
Juror Guidelines
Assignment Order
Chief Judge's Office
Circuit & Associate Judges
State's Attorneys
Circuit Clerks
E-Filing Programs
Language Access Plan
Approved Traffic Schools
Standardized Forms
JUDICI
JUDICI Website
Communication for Deaf and Hard of Hearing
Guide to Small Claims Court
Simplified Divorce
Defendant's Rights Poster
Courtroom Dress Code
Councils & Organizations
Family Violence Coordinating Council
Juvenile Justice Council
Fourth Circuit Family Violence Coordinating
WHAT IS THE FAMILY VIOLENCE COORDINATING COUNCIL?
The FVCC of the Fourth Judicial Circuit is a body of local decision makers from all systems that have contact with family violence victims and perpetrators. These include judges, probation officers, state's attorneys, public defenders, law enforcement officers, circuit clerks, victim advocates, clergy, hospitals and health care providers, social services, DCFS, educators, mediators and victim service providers.
The Council engages in education, prevention and coordination of intervention and services for victims and perpetrators of child abuse, teen dating violence, domestic violence, sexual assault and elder abuse.
There are six Issues Committees that meet to address issues of family violence in the nine counties in the Fourth Judicial Circuit. Tur Planning/Steering Committee meets to determine the direction that the FVCC will take, what issues need to be addressed by the Council and the topic of the annual Symposium/Full Council Meeting.
WHAT ARE THE ACCOMPLISHMENTS OF THE FOURTH JUDICIAL CIRCUIT FAMILY VIOLENCE COORDINATING COUNCIL?
Annual Symposium/Full Council Meetings with nationally-known speakers
Protocol Development & Training for Hospital Staff
Domestic Violence & Stalking Protocol Development & Training for Law Enforcement Officers
Development of Victim's Packets for Law Enforcement Officers to use in domestic violence cases
Protocol Development & Training and Teacher's Sheets for Educators & School Staff on their Response to Victims of Family Violence
Development of a Quick Clergy Guide
Workshops & Trainings on The Link Between Animal Abuse, Child Abuse and Domestic Violence
Workshop on the Effects of Domestic Violence & Methamphetamine on Children
Teen Dating Violence Workshops for Junior & Senior High Students
Mandated Reporting Training
Stalking Training for Advocates & Law Enforcement Officers
FOID Card, Domestic Violence & Mental Health Training
Religion: As a Roadblock & a Resource for Domestic Violence Victims Workshop
Living in Their Shoes: Domestic Violence and Homelessness Workshop
Internet Crimes Workshop
Child Sexual Predators Workshop
Elder Abuse Workshop
The Fourth Circuit FVCC has also compiled a large collection of resources to assist in education of professionals and the general public.
WHAT IS THE FUTURE DIRECTION OF THE FOURTH JUDICIAL CIRCUIT FAMILY VIOLENCE COORDINATING COUNCIL?
The FVCC believes that the reduction of family violence is central to the reduction of other forms of violence. Reducing and preventing family violence will contribute significantly to the creation of communities that are safe, secure and healthy.
DISCLAIMER: The Fourth Judicial Circuit, Office of the Chief Judge provides this web site only as a source of public information on the Fourth Judicial Circuit. All efforts are made to ensure that information and links are accurate and current. However, users should not cite this information as an official or authoritative source and are advised to independently verify all information. Information contained on this web site should in no way be construed as legal advice. Users should contact an attorney if they require legal assistance or advice .
© 2018 Fourth Judicial Circuit Court of Illinois. All rights reserved.
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Research & Grant Programs
Spotlight on Research
Written on March 14, 2018 .
Dr. Jasjit Dillon
Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-Operative Treatment
Dr. Jasjit Dillon, DDS, MBBS, FDSCRCS, FACS is Clinical Associate Professor and Chief of Service and Program Director at The University of Washington's Harborview Medical Center, Department of Oral & Maxillofacial Surgery.
Based in Seattle, WA, Dillon is the principal researcher and is joined by a global team of co-investigators spanning multiple locations: Salvatore Ruggiero, DMD, MD, FACS, New York Center for Orthognathic and Maxillofacial Surgery (New York, NY); Anthony Morlandt, MD, DDS, Assistant Professor of OMFS, University of Alabama (Birmingham, AL); Daniel Hammer, DDS, Collaborator, Chief Resident, Walter Reed National Military Medical Center – Department of OMFS (Bethesda, MD); and Brent Ward, MD, DDS, Associate Professor, University of Michigan (Ann Arbor, MI).
Dr. Dillon was awarded one of the 2018 Osteo Science Foundation Peter Geistlich Awards to pursue research on Pentoxifylline and Tocopherol in the Treatment of Medication-related Osteonecrosis of the Jaw. Dr. Jasjit Dillon discusses her interest in this research and how this research will help in finding a solution for patients dealing with MRONJ. This project is also funded by the OMFS Foundation.
Medication-related osteonecrosis of the jaw (MRONJ) is a challenging complication of antiresorptive and antiangiogenic treatment. First reported over a decade ago, it is now a well-known entity, and its management and treatment remain a significant clinical challenge. In fact, over 6 million U.S. patients are estimated to be at risk of MRONJ.
"This is such a global problem", explained Dr. Jasjit Dillon, Chief of Service and Program Director at the University of Washington's Harborview Medical Center. "We – as a specialty – discovered this condition and the problems aren't going away. We now need to take it to the next level and find a solution to help patients and improve their quality of life."
Dillon is spearheading new research that builds on the promise that adjunctive therapy with pentoxifylline and tocopherol (PENTO) is an effective, etiology-based treatment in improving the prognosis of osteoradionecrosis of the jaw (ORN). The study's goal is to determine if the PENTO regimen, in addition to the standard of care treatment for MRONJ, significantly reduces the areas of exposed bone compared to standard of care alone.
"We're looking at a combination of two drugs to assess whether a patient's bone will heal," said Dillon. "We'll be looking for radiographic improvement, pain improvement, and a potential decrease in the number of new lesions."
Pentoxifylline is a commonly used medication for muscle pain associated with peripheral artery disease. It is a methylated xanthine derivative that improves peripheral blood flow, flexibility of red blood cell membranes, microcirculation, and tissue oxygenation and reduces viscosity of blood. Tocopherol (vitamin E) impairs tissue fibrosis and is a potent oxygen radical scavenger that may reduce damage caused by free radicals impacting necrosis. Because of the similar clinical presentations of ORN and MRONJ, some authors have successfully applied PENTO treatment protocols to MRONJ patients. In that regard, Dillon noted that the possible impacts of the drug study can be significant.
"One of the most exciting aspects of our study is that if PENTO is proven effective in the treatment of MRONJ, practitioners will have a regenerative treatment option for MRONJ." While the specific model of MRONJ pathogenesis can be debated, the most recent research demonstrates an MRONJ lesion as a combination of necrotic and compromised bone. "The application of PENTO to MRONJ lesions may enhance remodeling of the compromised, yet vital bone." However, Dillon added that for remodeling to occur alone, the tissue being remodeled must be vital. "The area that is necrotic is cleared innately, not 'regenerated.'"
MRONJ is typically seen in cancer patients receiving intravenous bisphosphonates or other similar drugs to address cancer that has spread to the bone. Osteoporosis patients receiving these medications are also at a higher risk for MRONJ, but to a lesser degree. As such, these patients are a particular target of the study because they encounter progressive bone destruction with morbidity, along with pain and suffering. Dillon explained, "When patients take these drugs, there can be side effects, and one of them is when the jaw bone just dies, or when its ability to heal is impaired. We have a protocol, but we don't have a cure."
Obtaining better treatments for people who have MRONJ and identifying effective preventive measures to reduce its risk are well recognized needs within oral surgery. To that end, Dillon cited PENTO as a potential, affordable non-surgical treatment modality for MRONJ that could reduce associated morbidity and reverse progression.
Currently, standard of care management of MRONJ is limited to symptom-focused treatment consisting of antibiotics, antibacterial mouthwash, analgesics and limited debridement of necrotic bone. This study is particularly notable because the present evidence for effective PENTO treatment in MRONJ patients is anecdotal, and larger, prospective, randomized clinical trials such as this investigation are needed to evaluate effectiveness.
This study is a randomized placebo-controlled, triple-blinded trial, and while it's just getting underway, its promise is already noteworthy. "If our study supports the results of the PENTO regimen, oral and maxillofacial surgeons and a multitude of other medical and dental providers that care for the affected patient population will have an additional non-surgical treatment modality", explained Dillon. "We're excited because this has the potential to help a lot of people." Ultimately, such an approach could lead to decreased overall physical and psychological morbidity with improved patient outcomes.
Author: Andrea Boidman
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For an appointment with a high-risk pregnancy specialist, call 202-877-3627.
There is a new treatment option for those who suffer from vein problems: the VenaSeal™ Closure System.
MedStar Heart & Vascular Institute is the first in Washington, DC, and Maryland to offer this new therapy.
Misaki Kiguchi, MD, is a board-certified vascular specialist with special interest and experience in treating vein disorders. A graduate of Yale University School of Medicine, the University of Pittsburgh Medical Center and its Magee-Womens Hospital, Dr. Kiguchi has extensive training in the complete spectrum of arterial and venous diseases. Dr. Kiguchi specializes in vein disorders, using the most advanced and effective treatments and therapies.
call 202-877-3627 to schedule a consult with Dr. Kiguchi at her Chevy Chase office.
Bladder cancer is the fifth most commonly diagnosed cancer in the United States with a high rate of recurrence. Unfortunately, up to 30% of bladder tumors are overlooked, because they are often too small to see with the standard testing method called cystoscopy.
Fortunately, a new, FDA-approved method now available at MedStar Washington Hospital Center is helping doctors identify bladder tumors earlier thanks to better imaging. The technology is called Blue Light Cystoscopy with Cysview®.
During this test, the patient is given a solution that is absorbed by the cancerous tissue. This causes it to appear fluorescent when exposed to "blue light," which is created by a special camera and lens. This allows urologists to detect more of the cancer, remove it, and provide treatment to keep it from coming back.
New guidelines from the Centers for Disease Control and Prevention recommend that adults 65 years and older receive two vaccines to protect against pneumococcal disease, up from the previous recommendation of only one.
Pneumococcal infections may range from sinus infections to pneumonia, which is one of the leading killers of older adults in the United States.
Historically, adults over 65 without certain health complications were instructed to receive the pneumococcal polysaccharide vaccine (PPSV23) after turning 65. Now, they are encouraged to also get the pneumococcal conjugate vaccine (PCV13). These two vaccines work in different ways to expand protection against pneumococcal infection.
Healthy adults older than 65 who have never been vaccinated should first get the PCV13, then the PPSV23 one year later. For those that have previously been vaccinated with PPSV23, the PCV13 is recommended at least one year after the last PPSV23. Adults with certain health conditions may require a different vaccination schedule.
Dr. Wortmann recommends asking your primary care doctor if this vaccination should be added to your immunizations.
To schedule an appointment with Dr. Wortmann, or to get a referral for a primary care doctor, call 202-877-3627.
Jim Robinson, MD, says the most common problem that sends women to their gynecologists is abnormal uterine bleeding. And one of the most common structural reasons for abnormal bleeding is the presence of fibroids. More than 50 percent of all women, and 80 percent of African-American women, have them.
But this doesn't mean you should be overly concerned. Dr. Robinson says that fibroids can be taken care of – usually in a minimally invasive way.
Procedures are usually done on an outpatient basis, using small incisions and precise targeting – which means less pain and a quicker recovery than traditional, open surgery. If you haven't completed your family, fibroids can be removed through keyhole incisions. If a hysterectomy is the route that you and your doctor choose, Dr. Robinson says that "it isn't your mother's hysterectomy – you won't automatically go into menopause." Whenever possible, the ovaries are preserved; they create testosterone, which is important for healthy aging. The surgery can be performed through a small incision and is now often an outpatient procedure.


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