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How Much Does A Pop Up Camper Cost? [2022 Updated]
February 14, 2022 January 31, 2022 by Brian
If you're out on an outdoor escapade — whether it be the mountains or the shore — you can always count Popup campers to keep things easy and simple. They're a great option, especially for growing families who are always on the go and typically need more room than usual. While they may not provide the perks that a travel trailer, motor home, or 5th wheel can offer, they nonetheless serve as an excellent choice for camping lovers. Its tented sleeping quarters not only allow you to sleep soundly under the vast expanse of stars but also make sure you're comfortable and cozy while you're at it.
Popup campers are typically tent trailers or fold-out campers that can collapse into a much portable and smaller package due to their partial canvas construction. Similar to travel trailers, they also have functioning bathrooms, large mattresses, and a mess area as well. Popup campers are convenient since they save you the hassle of hauling heavy and massive trailers for when you're out on an adventure. Instead, you can merely fold them into a handy package that's far easier to manoeuvre and tow compared to a full-sized trailer.
Not only that, but one significant advantage with opting for Popup campers is that they tend to be less expensive, making them easily accessible and affordable for many. They're also an easy first step from camping in a tent, which is a great choice for those who are seeking to try camping for the first time. Depending on the type of camper you purchase, some Popup campers come with dining areas, bathrooms, kitchen, and heaters apart from beds.
1 Popup Camper Costs At A Glance:
2 Best Affordable Popup Camper:
3 Diving Deeper: How Much Does A Pop Up Camper Cost?
4 Buying Vs. Renting A Popup Camper: Which Is Better?
5 Reducing The Cost Of Buying A Popup Camper:
Popup Camper Costs At A Glance:
Choosing the type of Popup camper that's best for you can be confusing at first, especially when there are plenty of options to choose from. Apart from the features that Popup campers have to boast, one thing you should particularly consider is cost. The cost of a popup camper typically depends on the age, model, as well as whether you are renting or buying in the first place.
Popup campers that are inclusive of luxuries such as front desk storage or heated mattresses will be more expensive than the basic one. That being said, there is a significant difference between the costs of a Popup camper that's new or used. If you're wondering how much is a new Popup camper, you can expect a new camper to cost around $10,000 to $20,000 on average or more depending on how extravagant you want it to be. On the other hand, used campers are generally cheaper since they're easily within the range of $2,000 to $10,000.
Best Affordable Popup Camper:
Now that you have a general idea about how much Popup campers can cost, it's now time to look at some worthy options available on the market. That being said, here are eight of the best Popup campers you can bring with you on your next camping adventure.
Coachmen Viking Express 9.0TD:
If you're looking for an affordable and budget-friendly option, the Coachmen Viking Express 9.0TD is an excellent choice. With just the price of $8,000, you can already enjoy a decent amount of features, such as its unique single-pivot design, which significantly lessens the complexity and setup time by this particular Popup camper.
However, despite its affordable price, the only downside to the Coachmen Viking is that it's not suitable for big family or friend groups due to its small size. It only offers a two-person sleeping capacity alongside a limited space in the interior.
Even so, the Coachmen Viking 9.0TD is still a great buy at just a low price since it's lightweight, compact, and simple all at the same time. It's also a great choice if you're only out with a friend or two or with your significant other.
Sylvan Sport GO:
The SylvanSport GO is impressive for its storage space despite its small size. Here, you can store just about anything under the tent pod, from bikes, motorcycles, camping gear, and more. You can also place some more of your stuff, such as kayaks or bicycles, above the tent pod on the equipment rack. Despite being small-sized at 80 inches long and 116 inches wide, it nonetheless sports a cool design and is also a hybrid of every Popup tent trailer. De
Its slideout is that it can only accommodate two adults and two children at the same time. Also, there isn't any internal toilet, so it would be a great idea if you opt for a decent composting toilet should you go ahead with the Sylvan. Even though it's relatively small compared to other campers, its roof can Popup to make for more ventilation and headspace.
Anyone will love this lightweight Popup camper because of how compact it is and how it can be easily towed. Moreover, the Sylvan Sport GO is ideal for people who have an affinity for the outdoors.
2017 Livin' Life Quicksilver 8.0:
While this Popup camper may look simple and small at first glance, you can say that a lot of effort and thought has gone into its exterior design. The Quicksilver is built on a superstructure made of aluminum, making it an efficiently lightweight camper. Unlike the hassle that comes into hitching a trailer, you'll find it convenient to do with the Quicksilver due to its manual crank swivel jack on the tongue that only requires minimal effort.
With two full-sized beds, the Quicksilver can easily accommodate up to four persons. Even so, you can make for more space for two more adults if you convert the dinette seating to a bedroom area. Though it doesn't have a bathroom, it contains two oven burners and a small sink for your use.
You also have the option to add features such as an aluminum rear storage rack to carry additional gear or an Off-Road package that substitutes the standard 12 inches by 15-inch tires with all-terrain ones.
Forest River Rockwood 1640LTD:
Another cheap Popup camper option you can go for is the Forest River Rockwood 1640LTD with just a price of $9,255.
However, the Forest River Rockwood is more than just its affordable price. It's also nimble and compact while sporting a lightweight design alongside a four-person sleeping capacity. Not only that, but it also has a wide, open interior perfect for groups. You'll also find no difficulty with this Popup camper since it only has a dry weight of 1,465 points, making it one of the lightest campers you can carry around and tow.
A wide variety of midsize and compact SUVs can easily pull this compact camper, such as the Kia Sportage, Honda Passport, Honda Pilot, and most minivans as well.
Black Series Alpha Camper:
The Black Series Alpha Camper is the Popup camper you need for off-road adventures since it's the most rugged on this list. This makes it all the more suitable for campers who want to go away from the campground and get off the beaten path.
The Black Series is an extreme and off-road Popup camper manufactured from the ground up to be one of the most rugged and well-built off-grid campers you can possibly purchase. For this, you can include some features such as
High ground clearance
Duragal tube reinforced chassis
Quad Shock Absorbers
Deep Cycle 100 Amp per Hour battery that you can charge with Tow vehicles
Twin lockable propane tank holders
Twin Lockable Jerry Can Holders
However, even with these off-grid features and heavy-duty materials, the Black Series Alpha Camper still prides itself on affordability since you can purchase it for only the average price of $9,995.
Aliner Scout Lite:
This A-frame Popup camper features hard, angled walls that allow for better insulation against extreme weather conditions. With the Aliner Scout Lite, you usually have two-floor plans to choose from. Nevertheless, both options come with a refrigerator, microwave, stove, sink, interior lights, fan, LED, and an outside shower.
While relatively more expensive than the other options, the Aliner Scout Lite is still the cheapest harder-sided Popup camper you can find at just $12 000. This is because of the fact that hard-sided options tend to cost more, unlike the usual tent-style options due to manufacturing costs and the unique benefits exclusive to hard-sided Popup campers.
The Scout Lite accommodates enough space to meet your daily needs while being compact enough to tow and maintain with minimal effort. It's ideal for one or two people, though four people can still have enough sleeping space.
Despite having clear advantages over the common tent-style design, its only downside is that its A-frame meant limited interior and sleeping space.
Forest River Flagstaff Hard Side T12RBST:
If the Aliner Scout Lite proves to be too expensive for your liking, the Forest River Flagstaff Hardside makes for a cheaper hard-sided Popup camper option that should be on your shortlist.
This Popup camper is packed with plenty of features that help make your trip more fun and enjoyable while still maintaining a reasonable economical price. For one, the Popup camper offers convenience features like a full kitchenette with sink, outdoor shower, three-burner propane stove, a fridge, solar prep, and a microwave.
Furthermore, it also has one of the biggest amounts of storage space you can possibly find in a Popup camper due to its huge exterior front storage locker and flip-up bed. This allows you to bring loads of outdoor and camping gear to your liking.
Coachmen Clipper LS 806XLS:
This Coachmen Clipper is the ideal box-size 8.5-foot Popup camper, thanks to its budget-friendly design and minimalistic design.
Its 18-inches and 54-inches wide dual insulated sleeping beds on either side allow for more than enough space for your family to sleep soundly inside the Popup camper. Moreover, it also offers plenty of features to make your camping trip stress-free and fun. It provides convenience features such as a hot and cold water sink, fridge, two-burner propane stove, 20,000 BTU furnace, 16-gallon freshwater tank, and a built-in awning as well.
Diving Deeper: How Much Does A Pop Up Camper Cost?
The cost of Popup campers goes beyond its purchase price; even so, it's still as good as any place to start. You're typically looking at a price range of $10,000 to $20,000, with the price spectrum simultaneously depending on the features, brand, and age of the model.
In a nutshell, you can have a rough idea of Popup campers' pricing by looking at its features and newness. For instance, the new basic models on the low-end are more affordable than most since it only features a small dinette, some cooking appliances, a mini-fridge, and a few beds. Budget models, while smaller than their expensive counterparts, are considered significant upgrades to a tent because they tend to offer square footage alongside other features as you go up in price. Some of these include heated beds, heater or air conditioner, TV, cooking appliances, toilet, and more.
Meanwhile, larger, new models tend to be pricier, going up beyond $20,000. Used Popup campers are the cheapest option among these; however, despite not being particularly new, an old Popup camper can serve you just as a new one can. You only have to look at whether or not it's been maintained well.
Buying Vs. Renting A Popup Camper: Which Is Better?
Popup camper pricing also largely depends on whether you are renting or buying it. When you purchase a Popup camper used at a reduced selling price, it still comes with similar costs to buying a new one. You will still need to maintain and insure it. Even so, you can still be able to purchase a lower-end camper in cash while simultaneously avoiding the financing cost.
Nonetheless, you still have a slew of things to consider when buying a used Popup camper, such as depreciation and more. With used Popup campers being older than the latest models, considering the cost of depreciation will allow you to determine whether a Popup camper is a great buy or not. For instance, fold-out campers tend to depreciate less compared to a new RV or vehicle, but they constantly lose value every year. You can expect about 20% within the first year and 10% per year afterward for around seven years.
On the other hand, the costs of renting a Popup camper often vary depending on where you live as well as the camper's type and size. Most areas tend to have average rent prices of $30 for each night and a top out of $100 for every night. You also have to factor in other costs beyond the nightly rent.
If you're someone who is confused about whether buying or renting a Popup camper is the most suitable choice to make, you first have to ask yourself how often you will use the camper. Also, you have to identify if you have a vehicle that can handle towing a Popup camper and whether or not you'll need to pay for storage space.
The answer varies from camper to camper; nonetheless, buying a Popup camper is the best option if you're one to camp often. Rental costs can add up more quickly than usual, but they make for a more affordable option compared to buying if you need to rent a vehicle and then pay for storage.
Reducing The Cost Of Buying A Popup Camper:
If you're looking to buy Popup campers on a set budget, there are some easy steps you can keep in mind so you can reduce buying costs. The first is to pay up cash; however, you can also opt for these options below:
Consider renting it out: After purchasing your Popup camper, you can rent it at times you're not using it and also opt to recoup your purchase price however you want.
Buy an older model, new: If you can find one, it's also a good idea to buy a relatively older Popup camper. Through this, you can obtain a Popup camper that comes with high-end features at a significantly lower price.
Shop end-of-year sales: If you decide to buy at a Popup camper dealer shop at the near end of the year when they're highly likely to make room for new inventory — don't forget to always negotiate.
Buy from a private dealer: Even if it isn't a heavily used and older camper, you'll find yourself paying less if you buy from private sealers than going for a dealership.
How much should I spend on a used Popup camper?
Used campers tend to have lesser prices than newer ones. For this, you can expect a price range of $2,000 to $10,000.
Is it worth buying a Popup camper?
Popup campers are among the most budget-friendly options on the market compared to RVs. However, buying one may not be worth it if you only camp scarcely. Otherwise, you can get a Popup at just a fraction of its cost, and since they tend to cost less to start, that makes them cheaper to insure at the same time.
How long do Popup campers last?
Popup campers can last for about 10 to 15 years on average, depending on how often you use it and how well you maintain it. Some Popup campers last less than the average years, and most of it is due to their owners not knowing how to take care of them properly.
Popup campers are great for adventure-seekers who are always down for camping, all at an economical price. Not only are they compact and lightweight, unlike your usual RVs or trailers, but they also offer plenty of great features that ensure a memorable camping experience for everyone. Depending on what you're looking for in a Popup camper, pricing costs generally depend on its features, newness, age, and model. You also have to consider whether buying or renting is the most suitable option for you; that way, you can arrive at the best choice when it comes to purchasing the option that best caters to your needs.
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Egyptian Liberal: The Taliban Are 'Hostile To Life'; Whoever Celebrates Their Victory Needs His Head Examined
In an August 16, 2021 article in the Egyptian daily Al-Watan, liberal thinker Dr. Khaled Montaser, a physician and media figure, castigates those who rejoiced at the Taliban's rise to power in Afghanistan and saw it as a victory for Islam and the Muslims. The Taliban, he says, is a fascist religious movement that seeks to kill joy and is hostile to life and humanity themselves, as evident from its ban on Covid and polio vaccines. This movement is incapable of establishing a modern state, he concludes.
Khaled Mintaser (Source: Al-Watan, Egypt)
The following are translated excerpts from his article:[1]
"I started expecting the Taliban to advance towards any part of Afghanistan the day they killed Afghan comedian Nazar Mohammad and mutilated his body to intimidate [others]. Horror indeed intensified, and the murderers won. Nazar, known as Khasha Zwan, was known to his friends as a lover of comedy who posted funny videos on Youtube. He lived in Kandahar, a Taliban stronghold. He was surprised [in his home], abducted, tied and [forced into] a vehicle. A video circulated later shows Taliban soldiers slapping him and laughing, and another video showed them mutilating his body!
"The killing of humor marks the beginning of the path of deterioration and destruction… The Taliban's first and most important decision was to remove pictures of women from billboards, smash store windows mannikins and of course mandate the wearing of the chador, the Afghan niqab. Religious fascism intensified, until they reached the point of killing joy and then proceeded to kill life itself by forbidding Afghans to get vaccinated for Covid-19.
"In March, [2021, Afghan] officials reported that Taliban gunmen had killed three women in Jalalabad in eastern Afghanistan who worked vaccinating [the populace] against polio… In June [2021], five members of the polio vaccination teams were killed and four were wounded in a series of coordinated attacks in three different places in eastern Afghanistan.
"The Afghan media reports that the Taliban in Paktia in the east of the country has [now] banned the Covid-19 vaccine as well. The Afghan Shamshad television channel quoted Wilayat Khan Ahmadzai, head of the local public health department, as saying that, since taking over the area last week, the Taliban has banned getting the vaccine at the local hospital. The unit in charge of vaccines has been closed down for at least three days, and people are told that the vaccine is forbidden…
"Is this unreasonable behavior the Taliban's way of becoming more liberated and civilized? Can those who are hostile to humanity and life be part of the modern [world]?
"The disaster is that some of our young people are writing [with admiration] of the Taliban's great victory, their takeover of Kabul and their invasion of Kandahar! Do they think that [the acts of] exiling people, stoning them, killing and perpetrating massacres herald the establishment of a [modern] state, the building of a nation and the revival of the homeland?!
"Whoever believes that what is happening in Afghanistan is a victory for Islam and the Muslims needs to have his head and his intelligence examined."
[1] Al-Watan (Egypt), August 16, 2021.

redpajama_set_name: RedPajamaCommonCrawl


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Society 24.04.20
Confinement measures across MENA as Ramadan takes off
The world's 1.8 billion Muslims began the observance of the holy month last night, with pilgrimages, festivities and communal prayers stamped on in unprecedented ways by the global Covid-19 pandemic. Mosques usually overflowing with believers are now closed, including those in Saudi Arabia, home to Mecca and Medina, the holiest cities in Islam. Nevertheless, a series of curfews and restrictions are loosening throughout the Arab World for the occasion.
The Kingdom will ease its confinement measures for the duration of the month of Ramadan. Previous restrictions to curb the virus meant Saudis could only leave their homes for health and food reasons between 6am to 3pm. During Ramadan, these hours are now extended to 9am until 5pm, officials announced, granted residents remain within the confines of their neighborhood. For precaution, a maximum of two people are permitted in the same vehicle when running these essential errands.
The Emirates has shortened its nationwide curfew by two hours, running from 10pm to 6am daily for the duration of Ramadan according to the state news agency WAM. Dubai now allows limited social gatherings, with 10 people maximum, for holy month festivities, as long as they following social distancing rules. One outdoor activity per day is also permitted, for a duration of up to two hours, an act that was previously banned entirely as part of the coronavirus lockdown.
Egypt is deducing one hour from its nightly curfew, starting at 9pm instead of the previous 8pm, still in place until 6am, as announced by Prime Minister Mostafa Madbouly. Although communal activities and mass prayers remained forbidden, Madbouly said restrictions such as allowing shops and restaurants to deliver food will be eased.
Hamas has no lockdown measures are currently in place, and will remain so during Ramadan while the West Bank has declared a state of emergency, a full lockdown has been eased to allow some businesses to partially resume their activity. Schools, wedding halls, restaurants all mosques remain closed, however. In Jerusalem, the al-Aqsa mosque will be closed for Ramadan for supposedly the first time since the birth of Islam.
Turkey is under lockdown, until April 27, with its markets and grocery stores usually operating from 8am to 11pm, extended to 9am to 2pm for the beginning of Ramadan. In additional accommodative measures, officials also taken steps to repatriate its citizens residing abroad for the holy month. The Foreign Ministry projects 25,000 citizens, from 59 countries, returned for the slightly-altered celebrations.
See also Ramadan 2020 preparations disrupted
#ramadan
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LIVE – Coronavirus: latest news on COVID-19
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Magic in Islam
Lebanon back on lockdown days after deconfinement
Keep up to date with the latest news on Arabia


This CT scan shows a cross section of the lungs of a person with lung cancer. The two dark areas in the middle of the screen are the lungs. The light areas in the right lung (on the left of the screen) represent the cancer.


Tusk has established a reputation for identifying and supporting an impressive range of conservation initiatives with an incredibly successful track record throughout Africa.
The Savé Valley Conservancy (SVC) consists of private, Government, and community-owned properties working together to manage animal populations on a landscape scale.
The Southern African Wildlife College (SAWC) was established in 1996 to give natural resource managers, at all levels, the motivation and skills they need to become partners in saving the continent's natural heritage.
The Tsavo Conservation Area (TCA) includes nearly half of Kenya's total protected area.
The Uganda Conservation Foundation (UCF) was founded in 2001 to support the work of the national conservation agency, the Uganda Wildlife Authority (UWA).
Vultures play an important ecological role by cleaning up dead carcasses and decreasing the spread of disease.
The eastern lowland, or Grauer's gorilla lives only in the Democractic Republic of Congo.
The Yankari Game Reserve is home to Nigeria's largest surviving elephant population, estimated at 350 individuals.
With nearly 40% of its land area protected for wildlife, Zambia has the large expanses of wilderness that are necessary to maintain healthy carnivore populations.


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authorThe Guardian
Google Chief rges Action to Regulate Mini-Drones
The influential head of Google, Eric Schmidt, has called for civilian drone technology to be regulated, warning about privacy and security concerns. The Guardian
Google's Eric Schmidt Warns on China's Attempts to Control the Internet
Eric Schmidt, the executive chairman of Google, has described China as "the most egregious" example of a nation attempting to control the Internet, as he issued... The Guardian
From ACM Opinion | March 21, 2013
Google Glass: Is It a Threat to Our Privacy?
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Google's Eric Schmidt: Drone Wars, Virtual Kidnaps, and Privacy For Kids
Google's chairman has sketched out a future world in which cyberterrorists are targeted by government drone strikes, online identities are taken hostage and held... The Guardian
From ACM Opinion | February 1, 2013
Is It Time For the Internet to Get the Plumber In?
The strange thing about the Internet is that it went from being something exotic to something mundane almost without us noticing it. The Guardian
Who Owns the Content You pload Online?
The outrage over Instagram's announcement that it is changing its terms and conditions has turned the spotlight on the relationship between websites and users who... The Guardian
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Here's a question: if you connect an unprotected Windows computer to the Internet, how long will it take before it is infected by malicious software? The Guardian
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At the end of April, Tor Books, the world's largest science fiction publisher, and its UK sister company, Tor UK, announced that they would be eliminating digital... The Guardian
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We are being watched. The Guardian
Why Cctv Has Failed to Deter Criminals
I've lost track of the number of people who've asked me to comment on David Cameron's insane plan to cripple Britain's Internet in times of civil unrest by blocking... The Guardian
Why Lulzsec Had No Choice but to Disband
After just 50 days, the group said it was ceasing individual operations. Why, when you might have thought things were going so well? The Guardian
Sony's Kaz Hirai on the Psn Hack
Sony's deputy president about the PlayStation Network hack, PS Vita and PS3's enduring appeal. The Guardian
Feds Versus the Hacker nderground: Army of Informers Turned By Fear
When Jeff Moss, popularly known as the Dark Tangent, started holding underground hacker conferences in Las Vegas he knew he had a problem. All previous gatherings... The Guardian
Google Is Polluting the Internet
The danger of allowing an advertising company to control the index of human knowledge is too obvious to ignore. The Guardian
From ACM Opinion | November 1, 2010
Why Minority Report Was Spot On
The launch of Microsoft's new Kinect games system, which allows players to run, jump, punch and shoot without having to wear strange clothing or hold any kind of... The Guardian


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Building a Nation Brick by Brick
October 1, 2014 • Business and Industry, Expansion and Reform, Windsor
Windsor brickmakers molding clay into wooden forms before turning them out in to dry, Mack Brick Company, ca. 1916
- Windsor Historical Society
Brick making was an important industry in Windsor even in its colonial days. Bricks used in the early colonies improved chimney construction and lessened the risk of catastrophic fires. Unfortunately, the bricks necessary for these improvements came from England and importing them was a slow and laborious process.
The discovery of a deposit of clay, approximately two-to-five miles wide, running from modern-day Wethersfield to Windsor Locks, helped facilitate brick construction in the colonies. The Connecticut brick industry started in Hartford in 1635 but made its way to Windsor by 1675. Windsor's rich clay deposits, when mixed with water and sand, produced high-quality bricks that supported the local industry for over 100 years.
Industrial brick making in Windsor began in 1830 with the founding of a firm by William Mack. Mack was a descendant of a Hessian soldier who fought for the British in the American Revolution. His company, which eventually became known as the Mack Harvard Brick Company (the "Harvard" added after the Mack Company provided bricks used in buildings on the Harvard University campus), set up headquarters on Pleasant Street in Windsor and remained a staple of the town's industry for six generations.
By the middle of the 19th century, close to 40 brickyards operated in Windsor. These were joined in the early 20th century by such competitors as Elijah Mills & Sons and the Windsor Brick Company. By this time, the Mack family alone produced six million bricks per year. They then doubled their capacity in 1923 with a move to machine-made brick. Millions of Connecticut bricks from Windsor, North Haven, Berlin, and Hartford made their way to urban centers throughout Connecticut and New York during this time.
Brick architecture remained in style throughout much of the early 20th century until the presence of new building materials, mainly concrete and steel, overtook the use of brick in the construction industry. Windsor's brick industry remained in operation, however, until the 1960s.
"Windsor Historical Society," 2016. Link.
Howard, Daniel. A New History of Old Windsor, Connecticut. Windsor Locks, CT: Journal Press, 1935. Link.
Pawloski, John. Connecticut Mining. Charleston, SC: Arcadia, 2006.
Loughlin, G. F. The Clays and Clay Industries of Connecticut. Hartford, CT: Hartford Press Case, Lockwood & Brainard Company, 1905. Link.
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text: Just fiddling with opengl stuff

redpajama_set_name: RedPajamaGithub


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Karl-Heinz "Kalli" Mödrath (* 22. September 1951 in Kerpen) ist ein ehemaliger deutscher Fußballspieler.

Laufbahn
Karl-Heinz Mödrath spielte in seine Jugend für den SC Kerpen, bis er 1971 zum SC Viktoria Köln wechselte. Ein Jahr später erfolgt der erneute Wechsel zum Lokalrivalen SC Fortuna Köln. Die Fortuna, geführt von dem Präsidenten und Mäzen "Jean" Hans Löring, spielte in der Regionalliga West und strebte den Aufstieg in die Bundesliga an. Mödrath, mit seinen 1,66 m und 60 kg kein "Brecher"-Typ, kam in seiner ersten Saison 1972/73 auf 13 Einsätze und schoss dabei fünf Tore. Tatsächlich gelang Fortuna Köln in dieser Spielzeit der Aufstieg in die Fußball-Bundesliga.

Das darauffolgende Jahr 1973/74 in der Bundesliga brachte aber dann weder dem Verein Fortuna Köln noch dessen Stürmer Karl-Heinz Mödrath den erhofften Erfolg. Fortuna Köln kam auf den 17. Rang, die erreichten 25:43 Punkte konnten den sofortigen Abstieg nicht verhindern. Mödrath tat sich in der Bundesliga schwer. Er wurde viermal eingewechselt und erzielte dabei immerhin zwei Tore.

In den nächsten Runden in der 2. Bundesliga verbesserte Mödrath kontinuierlich sein Spielvermögen und entwickelte sich zu einem etablierten Torjäger der Liga. Der erneute Aufstieg mit SC Fortuna gelang jedoch nicht mehr. Mödrath erzielte 144 Tore in 248 Spielen für die Fortuna. Zur Runde 1982/83 wechselte der inzwischen 31-Jährige zu Alemannia Aachen. In seiner letzten Saison in der 2. Bundesliga kam er nochmals auf 25 Einsätze und 7 Treffer. Mit seinen 151 Toren ist Mödrath hinter Simon Terodde (153) und Dieter Schatzschneider (153 Treffer) der dritterfolgreichste Torschütze in der Geschichte der 2. Bundesliga und mit 99 Treffern in Heimspielen außerdem der erfolgreichste Heim-Torschütze. In der Rangliste der Auswärtstorschützen reichen seine 51 Treffer auf fremden Plätzen zu Rang Drei. Von Aachen aus ging er für ein Jahr nach Hongkong zur Eastern AA, wo der legendäre englische Fußballer Bobby Moore sein Trainer wurde. Anschließend ließ er seine Karriere von 1984 bis 1985 beim SC Viktoria Köln in der Oberliga Nordrhein ausklingen.

Ab 1989 war er Mitglied der Traditionsmannschaft des 1. FC Köln.

Erfolge
 In der Saison 1978/79 wurde Mödrath mit 28 Toren Torschützenkönig in der Gruppe Nord.
 Hinter Simon Terodde (153) und Dieter Schatzschneider (153 Tore) belegt Mödrath mit 151 Toren den 3. Platz in der Ewigen Torschützenliste der 2. Bundesliga.
 Er ist der Spieler, der die meisten Tore in der 2. Liga für einen Verein erzielt hat.

Privat
Karl-Heinz Mödrath arbeitet nach seiner aktiven Zeit im Sportamt der Stadt Frechen. Er wohnt dort im Stadtteil Habbelrath.

Weblinks

Einzelnachweise

Fußballspieler (SC Fortuna Köln)
Fußballspieler (Alemannia Aachen)
Fußballspieler (SC Viktoria Köln)
Deutscher
Geboren 1951
Mann

redpajama_set_name: RedPajamaWikipedia


Reuben is very much into small sized toys that he can carry around with him – plastic diggers, matchbox cars, Octonaut Gups, his duplo "rocket" and a stack of toy trains. The issue we have is that he likes to bring more than he can carry with him not only around the house, but if we are going to stay at Nonna's house, or heading away on a short break. We normally limit the madness to what will fit in a small lunchbag that he can carry around himself – that was until we received a Bivouac Kid, Billibag.
The Biviouac Kid Billibag is a stylish and practical storage bag come playmat that easily transitions from Reuben's bedroom, out to the kitchen so he can move his toys around with him with the pull of the drawstrings. It is quite large, so fits all he needs, but is still a bit large for him to carry by himself. We ended up at Nonna's house last weekend, and it enabled him to throw his toys in, and then we did up the drawstrings and put it in the car, and then when he got to Nonna's he could just lay his toys out on their floor.
It also features two sturdy black handles that mean the bag and his toys currently can live on the door handle in his bedroom so they stay off the floor and out of the way when he isn't playing with them, and easy to grab and move to another room. We have the bag in white, but it comes in a range of fun colours. Easy to wash and dry, we think it would be great for a trip to the beach even with all the sand toys and as a rug to sit on when he gets there.


This year we spent Halloween in Saskatoon, not because we thought it was a good idea to travel for the one day holiday but because Greg's Grandpa Emil passed away the previous weekend and his funeral was planned for November 1st. As sad a reason it was for us to be in Saskatoon, it was a great opportunity for Finley and Penelope to go trick or treating with their cousins. They were all very excited.
Easton was a biker and was too cool to go trick or treating with his younger brother and cousins. I did try to steal his candy later on with no success.
This is my cousin Chris who is truly a kid at heart as you can tell in this photo. His son had the same Monster High glasses as Finley did so he put them on. Finley thought it was the funniest thing ever!
This is Michelle, my cousin Chris's wife. She went as a can of coke. It was a very warm costume not that it was all that cold in Saskatoon.
Viperine in action. Her and Ashton were gone in a hurry – practically running from house to house.
Penelope wasn't as fast as the older kids nor was she all that inclined to move even a touch faster so her and I went at her own pace. You would be surprised at how many people thought she was a tiger. Seriously, people, tigers have stripes. She was officially a leopard but she also agreed if you called her a jaguar, a kitty and a cheetah.
There was a house around the corner from my cousins' house. This was part of it.
This was the rest of the yard with the coffin going up in flames. It was seriously the greatest Halloween display I had ever seen.
This was after the first haul. It was ridiculous.
But they insisted on going back out for more but didn't last more then 30 minutes.
Post trick or treating fun. The girls managed to get a lululemon bag full of chips and a matching full bag of chocolate and random candy. In this neighbourhood, each street name has a Circle, Cres, Lane etc and all they did was walk the entire little area and got all that candy. People were very generous.
Thank you to Chris, Michelle, Easton + Ashton for having us for supper and for trick or treating. It was a lot of fun!


Hair, fashion, education and motivation are the cornerstones of our success. We look for people that are passionate, proactive, innovative, and believe in upholding the quality brand.
For over 7 years CHOPP has gained a reputation for being the place to work in Essex if you want to further your hairdressing career. We have strong principles and our philosophy ensures these values continue through the generations.


Blue Springs Post 499/Fike was too much for the Blue Springs Rod's Sports Athletics in Zone 2 East American Legion baseball opening doubleheader.
Outstanding pitching and defense led the way as Fike prevailed 7-0 and 7-1 Tuesday night at Hidden Valley Park.
Winning pitcher Danny McMurtrey and Josh Smetana combined for a one-hitter and 11 strikeouts in the opening game. Brian Burasco's sixth-inning double was the only A's hit.
McMurtrey struck out six in four innings for the victory. The loss went to Tyler Reed.
Fike (2-0) pounded out 11 hits, including a two-run homer by Gehrig Hudson and a solo blast by Smetana. Justin Ginter added three hits and Josh Hightower had two, including a double.
Jordan Oddo allowed only four hits in the second-game win. Spencer Schwandt took the loss for the A's (0-2).
Hudson doubled twice, Shay Parra singled twice and Stephen Montisano and Ginter each doubled to power Post 499.
Alex Duvall and Kyle Roberts each doubled for the A's, and Roberts doubled in the only A's run of the night.
Fike had only one error in each game.


If you are interested in joining our group or just want more information about Navion aircraft contact our President or Vice President.
SNAG dues are $20 yearly and are due in January of each year. You can join by sending your contact information along with $20 to Susan Holmes at the address listed to the left.


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(Redirected from Stable (horses))
For other uses, see Stable (disambiguation) and Stability (disambiguation).
Look up stable in Wiktionary, the free dictionary.
Horse stable interior.
A horse in a box stall.
A stable is a building in which livestock, especially horses, are kept. It most commonly means a building that is divided into separate stalls for individual animals. There are many different types of stables in use today; the American-style barn, for instance, is a large barn with a door at each end and individual stalls inside or free-standing stables with top and bottom-opening doors. The term "stable" is also used to describe a group of animals kept by one owner, regardless of housing or location.
The exterior design of a stable can vary widely, based on climate, building materials, historical period and cultural styles of architecture. A wide range of building materials can be used, including masonry (bricks or stone), wood and steel. Stables also range widely in size, from a small building housing one or two animals to facilities at agricultural shows or race tracks that can house hundreds of animals.
3 Other uses
The stable is typically historically the second-oldest building type on the farm. The world's oldest horse stables were discovered in the ancient city of Pi-Ramesses in Qantir, in Ancient Egypt, and were established by Ramesses II (c.1304-1237 BC). These stables covered approximately 182,986 square feet, had floors sloped for drainage, and could contain about 480 horses.[1] Free-standing stables began to be built from the 16th century. They were well built and placed near the house because these animals were highly valued and carefully maintained. They were once vital to the economy and an indicator of their owners' position in the community. Relatively few examples survive of complete interiors (i.e. with stalls, mangers and feed racks) from the mid-19th century or earlier.[2][3]
Traditionally, stables in Great Britain had a hayloft on their first (i.e. upper) floor and a pitching door at the front. Doors and windows were symmetrically arranged. Their interiors were divided into stalls and usually included a large stall for a foaling mare or sick horse. The floors were cobbled (or, later, bricked) and featured drainage channels. Outside steps to the first floor were common for farm hands to live in the building.[4][clarification needed]
Horses[edit]
Main article: Equestrian center
For horses, stables are often part of a larger complex which includes trainers, vets and farriers.
Other uses[edit]
The word stable is also used metonymically to refer to the collection of horses that the building contains (for example, the college's stable includes a wide variety of breeds) and even, by extension, metaphorically to refer to a group of people—often (but not exclusively) athletes—trained, coached, supervised or managed by the same person or organisation. For example, art galleries typically refer to the artists they represent as their stable of artists. Analogously, car enthusiast magazines sometimes speak of collectible cars in this way, referring to the cars in a collector's stable (most especially when the metaphor can play on the word association of pony cars).
Historically, the headquarters of a unit of cavalry, not simply their horses' accommodation, would be known as "a stable".
Traditional style barn, built 1802, still used as a horse stable.
A modest stable with a few stalls.
A shed row-style stable at a riding club in Panama.
Stables of the Einsiedeln Abbey, Switzerland.
A horse stable, over 100 years old, still in use at Stanford University.
A row-style stable in Žabnik at Sveti Martin na Muri, Croatia.
Media related to stables at Wikimedia Commons.
Horse care: Barns and stables
Glossary of equestrian terms
Livery stable
Nativity of Jesus
^ "Oldest horse stables". Guinness World Records. Retrieved 2016-06-27.
^ England, Historic. "Historic Environment Local Management Training Programme - Historic England". www.helm.org.uk. Retrieved 19 April 2018.
^ The Conversion of Traditional Farm Buildings: A guide to good practice (English Heritage publication).
^ "The Barn Guide by South Hams District Council". southhams.gov.uk. Archived from the original on 14 July 2014. Retrieved 19 April 2018.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Stable&oldid=934088028"
Buildings and structures used to confine animals
Horse management
Wikipedia articles needing clarification from October 2014
Commons category link is locally defined


FABP3 (fatty-acid-binding protein 3), also known as heart-type FABP or mammary-derived growth inhibitor (MDGI), is a small 15-kDa cytoplasmic protein transporting fatty acids and other lipophilic substances from the cytoplasm to the nucleus. It is most ubiquitously expressed in heart and skeletal muscle.
FABP3 promotes αSyn oligomerization associated with MPTP-induced neurotoxicity.
Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer's disease.
Aberrant fatty acid metabolism in skeletal muscle contributes to insulin resistance in zinc transporter 7 (Znt7)-knockout mice.
FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase67 Promoter Region.
Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization.
Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.


Cancer vaccines aim at eliciting not only an immune response against specific tumor antigens, but also at enhancing a preexisting immunity against the tumor. In this context, we recently reported on the levels of preexisting immunity in prostate cancer patients vaccinated with the HER-2 hybrid peptide (AE37), during a phase I clinical trial. The purpose of the current study was to correlate between preexisting immunity to the native HER-2 peptide, AE36, and expression of HLA-A2 and -A24 molecules with the clinical outcome. Additionally, we investigated the ability of the AE37 vaccine to induce an antitumor immune response against other tumor associated antigens, not integrated in the vaccine formulation, with respect to the clinical response.
We analyzed prostate cancer patients who were vaccinated with the AE37 vaccine [Ii-Key-HER-2/neu (776–790) hybrid peptide vaccine (AE37), which is a MHC class II long peptide vaccine encompassing MHC class I epitopes, during a phase I clinical trial. Preexisting immunity to the native HER-2/neu (776–790) (AE36) peptide was assessed by IFNγ response or dermal reaction at the inoculation site. Antigen specificity against other tumor antigens was defined using multimer analysis. Progression free survival (PFS) was considered as the patients' clinical outcome. Two-tailed Wilcoxon signed rank test at 95 % confidence interval was used for statistical evaluation at different time points and Kaplan–Meier curves with log-rank (Mantel-Cox) test were used for the evaluation of PFS.
Preexisting immunity to AE36, irrespectively of HLA expression, was correlated with longer PFS. Specific CD8+ T cell immunity against E75 and PSA146–151 (HLA-A2 restricted), as well as, PSA153–161 (HLA-A24 restricted) was detected at relatively high frequencies which were further enhanced during vaccinations. Specific immunity against PSA153–161 correlated with longer PFS in HLA-A24+ patients. However, HLA-A2+ patients with high preexisting or vaccine-induced immunity to E75, showed a trend for shorter PFS.
Our data cast doubt on whether preexisting immunity or epitope spreading specific for HLA-class I-restricted peptides can actually predict a favorable clinical outcome. They also impose that preexisting immunity to long vaccine peptides, encompassing both HLA class II and I epitopes should be considered as an important prerequisite for the improvement of future immunotherapeutic protocols.
Cancer immunotherapy aims to immune recognition and elimination of tumor cells and is a novel approach for effective management of patients with prostate cancer . Immune tolerance and tumor-induced immunosuppression often limit beneficial immunotherapeutic protocols . Therefore, active immunization with antigenic peptides is a proposed intervention that may help to overcome these obstacles. HER-2/neu (HER-2) is expressed in a high proportion of prostate tumors and overexpressed in castration-resistant patients [3–5]. HER-2776–790 (referred to as AE36) has been shown to induce potent immunologic responses and chemical hybridization to a tetra-peptide from the invariant chain of MHC class II molecules (Ii-key/HER- 2776–790 hybrid peptide or AE37) potentiates furthermore its action [6–8]. In our previous prostate cancer phase I vaccination clinical trial, we showed that AE37 not only induced potent immunologic responses , but also generated specific antitumor responses that could be detected even 3 years post booster inoculation . Patients expressing HLA-DRB1*11 and/or HLA-A24 alleles showed an increased vaccine induced immunological response which was followed by an increased overall survival (OS) . Additionally, we found that the AE37 vaccine has the potential to induce HER-2 specific CD4+ T helper cells (Th) that belong to the in vivo immunological memory repertoire and could even be detected 5 years after the first vaccine inoculation . Retrospective analyses of our results revealed that preexisting IFNγ immunity to the vaccine correlated with OS .
Clinical responses in cancer immunotherapies have been reported to be associated with several post vaccination biomarkers including frequencies of antigen-specific CD8+ cytotoxic T lymphocytes (CTL), delayed type hypersensitivity test (DTH) and autoimmunity [14–17]. However, pre-vaccination predictive biomarkers have not been developed sufficiently until now. Preexisting host immunity to vaccine candidate peptides before vaccination, has been proposed as a predictive biomarker of this kind, as it could act as a basis for the selection of suitable peptides for vaccination, in order to induce potent anti-tumor response that could provide cancer patients with clinical benefit . Sasada et al. reported a new immunotherapeutic approach named personalized peptide vaccine, in which they selected antigen (HLA)-matched vaccine peptides based on the preexisting host immunity before vaccination and conducted phase I and II clinical trials, with improved antigen-specific immune responses and promising clinical outcomes .
CD4+ Th cells have been shown to play a pivotal role in antitumor immunity [18–21]. They help priming of tumor specific naïve CD8+ T cells, maintenance of CD8+ T cell memory and prevention of tolerance. They also induce proliferation and differentiation of CD8+ T cells into tumor specific effector CTLs capable for infiltration into tumor microenvironment [22, 23]. Vaccination with a HER-2 helper peptide could elicit tumor specific CTLs via cross-presentation . Hence, vaccine induced immune responses might be directed not only against the targeted epitope but also against a broad range of tumor associated epitopes through epitope spreading [9, 25]. The AE37 peptide vaccine has also been reported to stimulate CD4+ Th cells rendering them capable of inducing immunologic memory and persistent stimulation of CTLs. Vaccine-induced T cells, secreting mainly Th1 cytokines, may activate dendritic cells (DCs) hosted in tumor microenvironment. Under these conditions the phenomenon of cross-presentation could be enhanced resulting in an epitope spreading .
In the current study we investigated a possible correlation between preexisting immunity to AE36 combined with the expression of certain HLA- molecules and progression free survival (PFS), in prostate cancer patients, who had been vaccinated with the AE37 hybrid peptide during our phase I clinical trial . Additionally, we tried to answer the question of how preexisting immunity to other known tumor associated CTL antigens might affect patients' clinical outcome and if it can be further enhanced by AE37 vaccination through epitope spreading.
The present study involves prostate cancer patients enrolled in the phase I clinical trial of the AE37 vaccine (Ii-Key/HER-2/neu (776–790):Ac-LRMKGVGSPYVSRLLGICL-NH2), EudraCT2006-003299-37 [9, 11, 27]. The current study was approved by the Institutional Review Board of Saint Savas Cancer Hospital. Upon inform consent, patients received 6 monthly inoculations (primary vaccination series; PVS) with AE37 plus GM-CSF as immunoadjuvant, followed by a single booster inoculation 6 months after completion of PVS. As previously described, 50 ml of whole blood was obtained by venipuncture at prevaccination and at different timepoints during and after vaccinations . PBMCs were isolated from blood samples by Ficoll (Biochrom) gradient separation at RT, washed twice in PBS and counted at Neubauer chamber. Viability was always >95 %. Cells were frozen in FCS/10 % DMSO at ≥1 × 107 cell/vial at −20 °C for 1 h, transferred at −80 °C overnight and afterwards stored in liquid nitrogen until use. PBMCs were thawed in pre-warmed RPM1 1640 culture medium (Gibco® by Life Technologies, Europe) supplemented with 20 % FCS, 0,5 mM L-Glutamine (Gibco® by Life Technologies, Europe), and 1X antibiotic-antimycotic (Gibco® by Life Technologies, Europe, ref:15240–062)] and counted at Neubauer chamber using trypan blue. The average viability was >70 %.
HLA typing was performed by PCR-SSP (polymerase chain reaction-sequence specific primers) as described previously . Patients' clinicopathological characteristics are presented in Table 1. Clinical progression was evaluated after enrolment of patients in the clinical trial. Based on the initial clinical status of each patient, clinical progression was defined as castration-resistance, metastasis (bone metastasis verified by radiographic evaluation) or death (Table 1).
Preexisting immunity for native HER-2/neu peptide AE36 (aa776–790: GVGSPYVSRLLGICL) was evaluated in the IFNγ-based ELISPOT assay, a widely applied technique for detection of functional effector T cells [13, 17, 28, 29], as previously described . Briefly, freshly isolated PBMCs were cultured in X-VIVO 15 medium (BioWhittaker, Cambrex) supplemented with 2 % AB human serum (Sigma), with the AE36 peptide (10 μg/mL) in precoated IFN-γ ELISPOT plates (MABTECH AB), in quadruplicates at 2.5 × 105 cells per well. The plates were incubated at 37 °C in a humidified 5 % CO2 incubator for 40 h and developed as described by the manufacturer. Spots were enumerated using an ELISPOT analyzer (A.EL.VIS GmbH) and data are presented as specific spots (experimental spots minus background spots; i.e., PBMC in medium alone) per 106 PBMCs. Individual values for IFNγ production were reported in our previous work .
Local dermal reactions (LR) were determined 48 h after each vaccination cycle by measurement of induration, as previously described . Each inoculation consisted of 500 μg of the AE37 vaccine mixed with GM-CSF as immunoadjuvant. Given the amount of the peptide along with the presence of the immunoadjuvant, we considered LR as a more appropriate method to evaluate HER2 preexisting immunity, compared to the standard DTH reaction (100 μg AE36 without GM-CSF). Beside this, it has been previously described that local reaction to the vaccination site can be used to evaluate immune responses in the context of immunomonitoring [30, 31]. Therefore, in the present study LR data represent measurements of induration presented as the orthogonal mean (mm) of the two sites of vaccine inoculation.
Antigen-specific T cells were detected by fluorescent MHC-peptide dextramers, which are multimers based on a dextran backbone bearing multiple fluorescent moieties . Such multimers are ideal for analyzing extremely low frequencies of antigen-specific T cells in peripheral blood in combination with multiparameter flow cytometry . Frequencies of CD8+ cells specific for tumor associated CTL epitopes, characterized as immunogenic by others and our group [34–42], were assessed with specific MHC-peptide dextramers using flow cytometry. The aforementioned assessment of antigen specific T cells was performed on cryopreserved samples as part of a retrospective analysis.
Only the most common alleles among our patient cohort, i.e. HLA-A2+ (n = 12) and HLA-A24+ patients (n = 12, with two of them co-expressing HLA-A2) were analyzed in this study, as all other haplotypes were expressed in very few patients, impossible to give any substantial information.
PBMCs were stained with commercially available MHC dextramers: A*0201-HER2369–377 (KIFGSLAFL) (referred to as E75)–FITC, A*0201-PSA146–154 (KLQCVDLHV)-FITC, A*0201-HER285–94 (LIAHNQVRQV)–PE, A*0201-HER2435–443 (ILHDGAYSL)-PE, A*0201-PSMA27–35 (VLAGGFFLL)-PE, A*0201-hTERT540–548 (ILAKFLHWL)-FITC, A*0201-Survivin96–104 (LTLGEFLKL)-PE, A*02402-PSA153–161 (CYASGWGSI)-FITC, A*02402-Survivin20–28 (STFKNWPFL)-PE (Immudex, Denmark). Briefly, PBMCs (1–3 × 106) were incubated with 10 μl of MHC dextramer for 10 min in the dark at room temperature, followed by staining with specific monoclonal antibodies anti-CD3-APC (UCHT1), and anti-CD8-PerCP (SK1)(BD Biosciences, Europe) for 20 min in dark at 2–8 °C. Fluorescent minus one (FMO) samples (without the dextramer) were used as negative controls. Samples were analyzed by flow cytometry on a FACSCalibur (BD Biosciences). 50000 CD8+ T cells were collected, thus determining the detection limit of accurate dextramer+ measurement at ≥0.1 %. Data analysis was performed using FlowJo software.
GraphPad Prism version five software was used for the statistical analysis of data. Two-tailed Wilcoxon signed rank test at 95 % confidence interval was used for statistical evaluation of patients at different time points. Kaplan–Meier curves and log-rank (Mantel-Cox) test were used for the evaluation of progression-free survival (PFS). Cut off limits for preexisting (R0) AE36 peptide-specific T cell frequencies (IFNγ producing cells in response to stimulation with AE36 at baseline) and LR at first vaccine (LR1) were calculated by cut off finder, http://molpath.charite.de/cutoff/index.jsp. In cases where the number of samples to be analyzed was <20 and thus the cut off finder could not be applied, X-tile software was used for defining the cut off for low- and high frequencies of tumor antigen-specific (dextramer-positive) CD8+ T cell populations . Rmax represents the time point during vaccinations with the highest frequency of antigen specific T cells detected. The ratio Rmax/R0 was considered high when value was >2, i.e. when Rmax was at least twofold above R0 frequency detected. Statistically significant differences were considered when the P value was ≤ 0.05.
Preexisting immunity to AE36 was evaluated by two different approaches. In the first, we evaluated prior to vaccination (i.e., time-point R0) ELISPOT-based IFNγ production, whereas the second was based on the size of local (dermal) reaction (LR1) 48 h after the first vaccination. We considered LR1 as a result of preexisting immunity to AE36 simply because the time-frame of 48 h post first vaccination is not sufficient for AE37 (or any other vaccine) to induce a primary immunologic response (in this case an AE36-specific response). Using cut off finder software, the study population was divided into two subgroups, patients with high or low AE36 preexisting immunity, according to the levels of IFNγ production (high levels: ≥ 25 spots/106 cells) and the size of LR1 (high: ≥10 mm induration diameter). The PFS analysis for a median follow-up time period of 58 months (range 7–65 months) estimated from the time of first vaccination is shown in Fig. 1. Median estimated PFS (mPFS) was not reached in the group of patients having high LR1 (n = 16), whereas mPFS in the low LR1group (n = 13) was 39 months [p = 0.001, hazard ratio (HR) =0.1222] (Fig. 1a). mPFS for patients having high IFNγ production (n = 10) was also not reached, whereas that for low IFNγ producers (n = 19) was 50 months (p = 0.0808, HR = 0.3433) (Fig. 1b). This significant difference for higher mPFS in the groups of patients with high LR1 or IFNγ preexisting immunity was much more intense when these patients were grouped together. Thus, mPFS in the group of patients having high LR1 and/or IFNγ preexisting immunity (n = 19) was, as expected, not reached being highly statistically significant (p < 0.0001) when compared to the group of patients with low LR1 and low IFNγ preexisting immunity (n = 10) (mPFS: 20.5 months; Fig. 1c).
HLA typing was performed on the 29 patients who were included in our studies. A substantial percentage (23 out of 29) of those expressed HLA-A2 (n = 13) or HLA-A24 (n = 13), with 3 of them expressing both alleles. For the patients carrying the HLA-A2 allele, no significant difference in mPFS was observed compared to non-carriers (Fig. 2a). However, we found a trend for increased mPFS among patients expressing the HLA-A24 allele vs those who were HLA-A24− (Fig. 2b). We next tried to correlate expression of HLA-A2 and HLA-A24 alleles in combination with preexisting immunity to the vaccine and mPFS. HLA-A2+ patients with high preexisting immunity had statistically significant longer mPFS than allele carriers with low (p = 0.0191), whereas a weak trend for improved PFS was observed between the HLA-A2+ and HLA-A2− patients with high preexisting immunity. In addition, in HLA-A2− patients, those with high levels of preexisting immunity exhibited statistically significant longer mPFS than those with low ones (Fig. 2c). In an analogous fashion, HLA-A24+ patients with high preexisting immunity had a strong trend for longer mPFS compared to those with low levels (Fig. 2d). Interestingly enough, similar mPFS was observed in patients with high preexisting immunity regardless of HLA-A24 expression (p = 0.7230). Finally, in HLA-A24− patients, those with high preexisting immunity showed statistically significant better mPFS than those with low preexisting immunity (Fig. 2d).
To conclude, these data show that preexisting immunity to the vaccine correlates with longer PFS to all patients regardless of their HLA allele expression.
Frequencies of CD8+ T cells specific for known immunogenic tumor associated CTL epitopes, not included in the vaccine, in patients' peripheral blood were determined by multiparameter flow cytometry in combination with MHC-peptide dextramers at each time point (R0, R3, R6, LT). We used the following MHC-peptide dextramers: A*0201-HER285–94 (HER285), A*0201-HER2435–443 (HER2435), A*0201-HER2369–377 (E75), A*0201-PSA146–154 (PSA146), A*0201-hTERT540–548 (TERT), A*0201-PSMA27–35 (PSMA), A*0201-Survivin M296–104 (SURV96), A*02402-PSA153–161 (PSA153), A*02402-Survivin20–28 (SURV20).
PBMCs were gated according to their FSC/SSC properties and then subgated to CD3+ cells which were further subgated to CD8− (i.e. CD4+) and CD8+ T cells. MHC-peptide dextramer+ cells were assessed within the gates representing CD4+ T cells and CD8+ T after substraction of corresponding negative control values. Initially, we correlated MHC-peptide dextramer+ cells at R0 and at any time-point of maximal response (Rmax) in HLA-A2+ patients (n = 12). Preexisting frequencies of CD8+ T cells specifically recognizing the E75 HER-2/neu peptide (CD8+/E75+ cells) were induced by the vaccine from a median of 0.59 % (range 0.15–1.49) at R0 to 1.61 % (range 0.18–2.98) at Rmax (p = 0.0025) (Fig. 3a). Frequencies of CD8+/E75+ cells at each time point (medians at R3: 0.50 %, R6: 0.83 % and LT: 1.72 %) are shown in Fig. 3b, with a statistical significant increase at time point LT vs R0 (p = 0.0177). Representative dot plots for negative control, R0 and Rmax for patient PR13 are depicted in Fig. 3c. The AE37 vaccine was also capable of increasing the frequencies of preexisting CD8+/PSA146 + cells from a median of 0.15 % (range 0.04–0.19) at R0 to 0.23 % (range 0.1–0.44) at Rmax (p = 0.0086) (Fig. 3d). CD8+/PSA146 + cells at each time point (medians at R3: 0.09 %, R6: 0.16 %, LT: 0.27 %) are shown in Fig. 3e, with a statistically significant increase at time point LT vs R0 (p = 0.0547). Representative dot plots for negative control, R0 and Rmax for patient PR6 are depicted in Fig. 3f. In both cases, percentages of dextramer+ CD4+ T cells, representing specificity controls, were minimal (Fig. 3b and e).
CD8+/HER285 + T cell frequencies at R0, were close to the detection limit of 0.1 % in 8 out of 12 patients (range: 0.02–0.08 % of CD8+ T cells), whereas in 2 of them, levels were increased upon vaccination (R0 vs Rmax: 0.08 % vs 0.11 % and 0.06 % vs 0.14 %) (Additional file 1: Figure S1A). In the remainder 4 out of 12 patients, CD8+/HER285 + cells at R0 were at relatively high numbers (0.10–0.19 % of CD8+ T cells) and in one of them, vaccination increased frequency levels from 0.17 to 0.40 %. For the total of 12 patients, CD8+/HER285 +cells were increased by the vaccine from a median 0.06 % (range: 0.02–0.19 %) at R0 to 0.12 % (range 0.04–0.4) at Rmax (p = 0.0025) (Additional file 1: Figure S1A). The levels of specific CD8+ T cells against HER2435, PSMA, SURV96 and TERT were at marginal levels at all time-points for the majority of patients, not allowing further evaluation (Additional file 1: Figure S1B-E).
Next, we correlated MHC-peptide dextramer+ cells at R0 and Rmax in HLA-A24+ patients (n = 12). CD8+/PSA153 + cells were induced by the vaccine from a median of 0.44 % (range 0.0–17.4) at R0 to 1.55 % (range 0.0–15.98) at Rmax (p = 0.0269) (Fig. 4a). Percentages of CD8+/PSA153 + T cells at each time point (medians at R3: 0.53 %, R6: 0.82 %, and R7: 1.41 %) are shown in Fig. 4b, with statistical significant increases compared to baseline at time points R6 and LT (p = 0.0273 and p = 0.0415, respectively). Representative dot plots for negative control, R0 and Rmax for patient PR14 are presented in Fig. 4c. Interestingly, prior to vaccination two patients exhibited high percentages of CD8+/PSA153 + cells that either remained unaltered or slightly increased (Fig. 4d, e). In the majority of patients, CD8+/SURV20 + T cells were detected at levels below 0.1 % prior to vaccination with a median of 0.06 % (range 0.01–0.28) (Additional file 1: Figure S1F).
Concluding, HLA-A2+ patients demonstrated preexisting immunity for E75 and PSA146 and HLA-A24+ patients for PSA153, which was enhanced upon vaccination with AE37 in a statistically significant manner.
HLA-A2+ patients were grouped according to preexisting immunity to E75 and PSA146. More specifically, patients exhibiting levels of CD8+/E75+ T cells ≥0.41 % were considered as having high and those below 0.41 % as low preexisting immunity (x-tile software, Methods section). With a median follow up of 58 months for all patients, mPFS of patients with high (n = 8) or low (n = 4) preexisting immunity to E75 were not reached, although we observed a trend for shorter PFS among those who had high preexisting immunity (p = 0.2618, HR = 4.159) (Fig. 5a). Next, we correlated the ratio Rmax/R0 for % CD8+/E75+ cells with mPFS. Patients with high Rmax/R0 ratio (>2; n = 6) had a strong trend for decreased PFS, compared to patients with low Rmax/R0 ratio, albeit mPFS was also not reached in the latter group (p = 0.0833, HR = 7.389) (Fig. 5b). mPFS of patients having high (≥0.06 %) or low (<0.06 %) CD8+/PSA146 + cells (Fig. 5c) and high (>2) or low (≤2) ratio Rmax/R0 (Fig. 5d) were not reached, and no statistically significant differences were observed among groups.
HLA-A24+ patients were grouped according to preexisting immunity to PSA153. mPFS of patients having high (>0.04 %, n = 9) preexisting immunity to PSA153 was significantly higher (i.e. not reached) compared to patients with low (≤0.04 %, n = 3) (i.e. 54 months) (p = 0.0017, HR = 0.0026) (Fig. 5e). Finally, we correlated mPFS with the Rmax/R0 of CD8+/PSA153 + cells. There was no difference in mPFS of patients with high (n = 8) or low ratio (n = 4) (p = 0.5770, HR = 0.4281) (Fig. 5f).
Regarding the HLA-A2+ patients, preexisting immunity to E75 or PSA146, might correlate with shorter PFS. On the contrary, longer PFS seems to apply for HLA-A24+ patients with preexisting immunity to PSA153.
Preexisting immunity along with epitope spreading are considered important factors securing an effective antitumor response, especially in the context of immunotherapeutic peptide vaccination. Beside this, others propose preexisting host immunity before vaccination as a basis for the design of efficient vaccination protocols [14, 15]. In line with this, we have previously shown that AE37 vaccination offered a clinical benefit in prostate cancer patients, with high levels of preexisting immunity to the native AE36 peptide detected by IFNγ ELISPOT . It is worth mentioning, that AE37 is a multipepitope vaccine, capable of inducing both specific CD4+ and CD8+ T cells in vaccinated cancer patients . The AE37 vaccine encompasses the immunogenic epitope of HER-2 p776-790 (the 15-mer AE36) which is subjected to the Ii-key modification for enhancing recognition by CD4+ T cells and also shows highly promiscuous binding to a series of MHC class II alleles with various affinities, as tested in binding and functional assays [44–46]. HLA class II-matched peptides such as AE36, may be particularly suited for activating CD4+ T cells in vaccination protocols thereby enabling their extensive interactions with other immune cells [6, 47]. We hypothesize that AE37-induced T-helper cells may engage dendritic cells at tumor sites, thereby cross-presenting antigens from apoptotic tumor cells and inducing epitope spreading.
Herein, we have addressed this issue by testing on our long-term survivors from the phase I trial for vaccine-induced epitope spreading. To this end, we have used MHC class I dextramers to identify both at baseline (i.e. preexisting) and during vaccinations, T cell responses (measured as % of dextramer-specific CD8+ T cells) against other HER-2/neu epitopes or against epitopes from other tumor antigens, representing intramolecular and intermolecular spreading, respectively. Because epitope spreading reflects an endogenous immunologic response closely related to the broader spectrum of tumor-specific preexisting immunity, we also analyzed our vaccinated patients for preexisting immunity to the vaccine by AE36-specific IFNγ-based ELISPOT assay and by LR1. We also planned to evaluate whether preexisting immunity to AE36 in combination with epitope spreading was predictive of treatment benefit. With respect to the latter, we analyzed frequencies of CD8+ T cells recognizing CTL specific epitopes restricted by HLA-A2 or HLA-A24, which are the most commonly expressed alleles among our study patients. It has to be mentioned that statistical significance could not be reached in many instances mostly due to the very limited patient numbers compared in each subgroup. However consistent trends can be interpreted as proof-of-principle data and require further consideration. Our data demonstrated that patients with high preexisting immunity to AE36, irrespectively of HLA-A2 or A24 expression, showed statistically significant longer PFS, than patients with low AE36 preexisting immunity, in accordance with our previous observation of improved OS in these patients with high baseline IFN-γ response to the peptide AE36 . Similar results were also obtained in a phase II clinical trial of breast cancer patients vaccinated with AE37 in the adjuvant setting . To our knowledge, this is the first observation which renders preexisting immunity to a long peptide vaccine as a predictive biomarker, for the selection of patients most likely to benefit clinically from vaccination.
Local reactions at different vaccinations cycles have been recently correlated with improved clinical outcome [30, 31]. Here, we propose for the first time LR1, i.e. the local reaction (induration) 48 h after the first vaccine, indicative of preexisting antitumor immunity, as a predictive surrogate biomarker for immunological and clinical responses in patients undergoing injections with AE37 and immunoadjuvant.
Based on our data, we detected preexisting immunity for several HLA-A2 and HLA-A24 restricted tumor epitopes in patients expressing the respective alleles, which was actually enhanced post AE37 vaccination. Of the epitopes analyzed, the HLA-A2 restricted E75 and PSA146–151 peptides as well as the HLA-A24 restricted PSA153–161 peptide were the most immunogenic ones based on their relatively high frequencies of CD8+ T cells (>0.15 %) at baseline, which were even further augmented during vaccinations. To unravel possible predictive significance of preexisting immunity for clinical outcome in our vaccinated patients, we correlated frequencies of CD8+ T cells, at baseline and during vaccinations, specific for the E75, PSA146–151 or PSA153–161 peptides, with mPFS of patients carrying the appropriate HLA restricting alleles. Our analyses showed that high levels of preexisting immunity to PSA153–161 correlated with significantly higher mPFS in HLA-A24+ patients, whereas no such correlation was observed in HLA-A2 carriers with preexisting immunity to E75 or PSA146–154 peptides. In contrast to our expectations, HLA-A2+ patients with high preexisting or vaccine-induced immunity to E75, showed a trend for shorter PFS than patients with low levels of such immunity. This observation could be explained by the assumption that although the immune system of these patients had a preexisting memory for E75 and responded by epitope spreading post vaccination, increasing epitope specific CTLs, they failed to interpret this to an effective clinical response, due to possible changes of the tumor immune profile. In line with this, results from a clinical vaccination study in melanoma patients, showed that no significant correlation was observed between clinical response and increases in the post vaccination peptide specific CD8+ tetramer+ T cells . Despite the fact that HLA-A2 may be an adverse prognostic factor in prostate cancer , it has been previously described that HLA-A2 along with HLA-C3 can predict prevention of relapse in melanoma patients vaccinated with Melacine . Moreover, encouraging results have been reported in a previous study, where HLA-A2 breast cancer patients received trastuzumab therapy concomitantly with a HER2/neu T-helper peptide-based vaccine, encompassing HLA-A2 immunogenic motifs, including E75 .
It is well known that altered expression of HLA class I, ranging from total loss to reduced expression of single loci and alleles, has been found in high frequency in several cancer types , including also prostate cancer , and is a mechanism which accounts for the selective outgrowth of tumor-escape variants during immunoediting [54–58]. Moreover, patients with prostate cancer and HLA class I abnormalities in their lesions, have poorer clinical outcome, than those with no detectable HLA class I antigen abnormalities in their tumors .
HLA-A*02 genotype has been reported to be a strong prognostic factor linked to the aggressiveness of ovarian cancer of serous histology, prostate cancer and malignant melanoma  with a selective loss found in these and other types of cancer [47–49]. The underlying mechanism for HLA-A2 loss has not been clarified yet. However, different hypotheses have been reported, such as up regulation of miR-181a, in different types of cancer [61–64], which has been previously associated with selective downregulation of HLA-A2 . Another hypothetical explanation of the poor prognosis that characterizes HLA-A2+ patients, could be rather genetic than immunological .
Another possibility could be the well known consequences of HER-2 expression on MHC class I restricted antigen presentation machinery, which connect HER-2 overexpression with downregulation of surface MHC class I expression [67–70]. These defects in components of the antigen processing and presentation machinery, induced by HER-2, obstruct the in vivo generation of class I restricted HER-2 derived epitopes, haltering tumor recognition by CTL . To this end, Norell et al. showed that metastatic ovarian tumor cells altered HLA class I expression through haplotype loss which was associated with inefficient HLA-A2-restricted immunity to HER-2 .
A third option could be that tumors with high expression of HER-2, as it is the case with progressed castrate resistant prostate cancer [3–5], are often characterized by alleviated capacity of being recognized by tumor antigen-specific CTL. It has been previously reported that especially for E75 immunization protocols, E75 specific vaccine-induced CTLs failed to recognize HER-2+ tumors  and HLA-A2+-HER-2 overexpressing carcinomas, even after IFNγ treatment . This could explain our observation that patients with high preexisting immunity against E75 and patients with induced E75-immunity upon vaccination with AE37 demonstrated shorter PFS.
Our data are also supporting the notion that preexisting AE36 immunity might be beneficial through induction of antigen specific CD4+ T cells, with cytotoxic function, that could successfully recognize tumor cells with down-regulated HLA class I alleles. Vaccine- induced CD4+ T cells with cytotoxic antitumor activities have been previously described [12, 75, 76]. Another important aspect of preexisting AE36 immunity is the local production of cytokines, such as IFNγ, by activated CD4+/AE36+ cells, which could not only restore tumor cells' HLA class I loss, but also activate components of innate immune system against tumor cells (e.g. NK cells, eosinophils, macrophages and neutrophils).
Our data although hypothesis generating, still they raise a very important issue by introducing an ambiguity whether preexisting immunity or epitope spreading specific for HLA-class I-restricted peptides can actually predict a favorable clinical outcome. They further strengthen the notion that peptide vaccines should contain HLA class II epitopes aiming at the activation of Th cells in order to counteract selective outgrowth of HLA class I negative tumor variants, under the pressure of immune selection mediated by tumor specific cytotoxic T cells. Thus, preexisting immunity to long vaccine peptides encompassing HLA class II, but also HLA class I epitopes, may offer an advantage in the clinical outcome of vaccinated patients, further contributing to the improvement of future immunotherapeutic protocols.
We thank Joanne Kalogeropoulou for the excellent technical assistance.
The project was supported from OPAP SA to MP.
The datasets during and/or analyzed during the current study are available from the corresponding author on reasonable request. Material is not available any more.
IFV and EAA equally contributed to data collection, analysis and interpretation of results and were the major contributors in writing the manuscript. PT was the responsible physician for the collection of patients' material and clinical follow up. MP gave the final approval of the version to be published. SAP and CNB equally made substantial contributions to conception and design, analysis, interpretation of data and critically revising the manuscript. All authors read and approved the manuscript.
Study has already been completed and details can be found in Perez et al. ref .


For each of our First Aid offerings, we have packaged the course content into different delivery modes to support teacher delivery when and where it fits into your timetable. These include one-day delivery (with knowledge pre-completed), two-day delivery and school term delivery.
Binnacle provides each of our partner schools with a real-time Status Report showing an up-to-date visual representation of your class progress. This is a cutting edge feedback mechanism designed specifically for VET in schools; ensuring program success is maximised.


Hangzhou, China, June 30, 2017 –Alibaba Cloud, the cloud computing arm of Alibaba Group, was included by Gartner, the world's leading research and advisory company, in its newly released Magic Quadrant for Cloud Infrastructure as a Service (IaaS) Worldwide (Lydia Leong et al. / Published Date: 15 June 2017). This is the first time that Alibaba has been positioned in the Quadrant, placing it in the top echelon of global cloud players.
Though new to the Magic Quadrant, Alibaba Cloud moves straight into the 'visionaries' section, a demonstration of Gartner's recognition of Alibaba Cloud's strong performance in cloud IaaS in China, and its growing investment in new markets.
The prestigious IT Research Group also noted Alibaba Cloud's diverse set of capabilities which "today are already comparable to the service portfolios of other hyperscale providers." This is in addition to a broad global data center presence, which demonstrates "the vendor's potential to become an alternative to the global hyperscale cloud providers in select regions over time."
Alibaba Cloud offers a comprehensive suite of cloud computing services to support growing enterprises worldwide, including data storage, relational databases, big-data processing, and content delivery networks. It also recently announced its plan to launch MaxCompute in Europe, a big data platform that allows users to store and process large volumes of data such as images, video and audio to levels as high as TB (terabyte) or even PB (petabyte) in the second half of 2017. The service is already available in Singapore, the headquarters of Alibaba Cloud's international business.
Alibaba Cloud operates in multiple regions across Mainland China and has a presence in Hong Kong, Singapore, Japan, Australia, the United Arab Emirates, Germany, and the U.S. (East and West Coast). With the three new data centers planned in Malaysia, India, and Indonesia, Alibaba Cloud will increase its total number of data center locations to 17, in a bid to support its rapidly growing international business and further strengthen its position both in APAC and across the globe.
Established in September 2009, Alibaba Cloud (www.alibabacloud.com), Alibaba Group's cloud computing arm, develops highly scalable platforms for cloud computing and data management. It provides a comprehensive suite of cloud computing services to support participants of Alibaba Group's online and mobile commerce ecosystem, including sellers, and other third-party customers and businesses. Alibaba Cloud is a business within Alibaba Group.


text:
Q: change value of XML element I have XML which is in project folder. I am loading the contents using this
    XmlDocument doc = new XmlDocument();
    string testFilesLocation = System.IO.Path.GetDirectoryName(System.Reflection.Assembly.GetExecutingAssembly().Location);
    string dataSource;
    string xmlFileName = "Claim.txt";

    if (System.IO.Directory.Exists(testFilesLocation + @"\Resources"))
    {
        dataSource = testFilesLocation + @"\Resources\" + xmlFileName;
    }
    else
    {
        dataSource = testFilesLocation + @"\" + xmlFileName;
    }
    doc.Load(dataSource);

XML has following nodes
<ClaimKeyInfo>
    <CompanyID>XXXX</CompanyID>
    <ClaimNum>XX-XXXXX-XX<ClaimNum>
</ClaimKeyInfo>

<ClaimInfo>
    <ClaimNum>XX-XXXXX-XX</ClaimNum>
    <ClaimSensitivityInd>N</ClaimSensitivityInd>
    <ClaimStatus>Open</ClaimStatus>
<ClaimInfo>

I am doing this to get ClaimNum elements
    XmlElement root = doc.DocumentElement;
    XmlNodeList elemList = root.GetElementsByTagName("ClaimNum");
    for (int i = 0; i< elemList.Count; i++)
    {
        elemList[i].InnerXml = "YY-YYYYY-YY";
        doc.Save(dataSource);
    }

I do get both the elements in elemList but I am not able to change the values inside it.
Any help would be appreciated.

A: You can use LINQ to XML for that.
var xDoc = XDocument.Load("filePath");
var numbers = xDoc.Descendants("ClaimNum");

foreach(var number in numbers)
{
    // do your work with numbers
    number.Value = "123456";
}

xDoc.Save("filePath");

Here, the numbers are contains XElements which is your ClaimNums.You can change the Value property and save the XML file.If you want to get specific numbers you can use Where extension method.If you want more details see these documentations:

*

*How to: Find an Element with a Specific Attribute

*How to: Find an Element with a Specific Child Element

redpajama_set_name: RedPajamaStackExchange


An advanced rejuvenating serum that protects against environmental and free radical damage by promoting dermal restoration. Provides unmatched protection on the skin.
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Has healing, soothing and moisturizing properties.
Neutralizes free radical damage, prevents sun damage.
The quick absorbing non-sticky formula the can be used under other creams or sunscreen.
Provides protection below the surface of the skin.
This Organic plant-based compound is a clinically proven antioxidant. Research indicates that exposure to ultraviolet light actually increases the antioxidant capacity and efficacy of ferulic acid. Ferulic acid prevents premature ageing as well as prevents the formation of skin cancer. Nano Ferulic acid blend with vitamin C & E renders these vitamins more effective than when used alone!
A potent stabilized form (15%) of an antioxidant that plays a key role in the synthesis of collagen which in turn has a plumping effect on the skin. Helps to diminish hyperpigmentation, redness and erythema.
Inhibits the development of scars and age spots as well as speeds up wound healing in the skin. It is highly moisturizing while boosting the performance of your SPF. Antioxidant protection protects against UVA and UVB radiation as well as free radical damage by reactivating oxygen radicals in the skin.
Nano Vitamin C+E with Ferulic is capable of holding up to 500 times its own weight in water above and below the surface of the skin. It is a powerful moisturizer with immediate water binding attributes that fill the void between the collagen and elastin fibres in the skin's dermal layer. Skin is plumped and well hydrated.
Wash and pat skin dry. If you are using a toner, apply the toner first.
Apply 5 – 6 drops of serum to your hands to distribute to your entire face, neck and surrounding area. Avoid the eye area.
Allow to dry. Can be used daily (morning & night) and under make up.


Marlon Bundo. Photograph by Hannah MacInnis/White House.
Make room on your bookshelves for an abundance of Marlon Bundo product. Regnery publishing announced Monday morning that Karen Pence has once again teamed up with her daughter Charlotte Pence to illustrate and write two books about their beloved pet rabbit. One, called A Day in the Nation's Capitol, is set for a spring 2019 release and will document the bunny's journey through the District of Columbia. The second, aptly titled Marlon Bundo's Best Christmas Ever, will launch in the fall of 2019 as a firm reminder that even house pets are unafraid to say "Merry Christmas" again. But the Pences don't want you to count Marlon out as any old pet—he's different.
"Little Marlon Bundo isn't just a family pet; with his popular Instagram account, Marlon has become a national celebrity!" the Regnery press release reads.
Charlotte Pence revealed the covers for the next two installments in the Bundo franchise on her Instagram story.
"We are still so awed and humbled by the reception and support we received with the first book, and truly honored to have the opportunity to turn it into a series with two more adventures with Marlon," added mother Karen Pence.
The pair's first foray into Bundo books, Marlon Bundo's A Day in the Life of the Vice President, is currently No. 26 in Amazon's ranking of Children's Book biographies, and No. 79 in Amazon's Children Books for Animals category. Last Week Tonight's Marlon Bundo parody book sold more than 180,000 copies in its first days in print. Think those are the only leporidae-based presidential books? Think again. Treat yourself to Thump: The First Bundred Days for the woodland creature Donald Trump crossover that nobody quite asked for.
This post has been updated to include quotes from Second Lady Karen Pence and her daughter Charlotte Pence.


I'm amused for some weird reason over the Japanese version of the official Mitsubishi Outlander site.
Update: MSNBC/Forbes reports that the Outlander was the worst selling model for Mitsubishi last year, selling only 11,848 units (including mine).
I really honestly think that is caused not by general car suckitude, but by the absolute lack of advertising on Mitsubishi's part. I had only learned of the car when a certain someone had researched Consumer Reports. In the past month I've seen at least 10 other Outlanders on the road around where I live, but that just could be because there is a well known Mitsubishi dealership nearby.
Update 04/02/06 - author's explanation: Yes, I do own an 2006 Outlander SE (purchased it off the dealer's lot just before the new year). After driving the vehicle for the past three months, with a little over 3,000 miles on the odometer, here are my impressions.
Overall, I would rate the car an A-. I'm extremely pleased with it, with my only real complaints with it being a little underpowered and I wish the gas mileage was a little better (I'm getting about 22mpg city). The spare tire in the back doesn't bother me like it does others, and I have to say that the car handles extremely well in rain and snow.
I'm glad I made the purchase. I enjoy driving again.
This entry was posted on Sunday, January 29th, 2006 at 9:57 pm	and is filed under General. You can follow any responses to this entry through the RSS 2.0 feed. Responses are currently closed, but you can trackback from your own site.
Just found this. Take a look at the list: gee, Ford sells mor pickup trucks than GTs. Wonder why!


While most of the work from home ideas emphasize on having a computer, access to internet, and using some sort of software or web based application, there are many work from home opportunities that do not required you to be wired or online.
Here are seven offline work from home ideas that you can use to work from home.
Childcare services. If you are energetic and have a natural flair for taking care of children, you can offer your services to look after your friends' or acquaintances' children. This will be a cheaper alternative as compared to other childcare services that charge a lot. Ensure that the number of children will be manageable for you. Prepare activities and arrange security of your venue, if needed.
Catering or Baking. If cooking or baking is your forte, you can choose this option. You can start small first, such as catering to a small party or accepting a few orders of baked goods every other day. Then, as your customer base grows, you may want to hire some extra hands to help you with your increasing orders. You may want to attend some cooking or baking lessons to ensure your skills are updated.
Errand Services. There is always a person out there who is just too busy to run errands. And if your social network is big, chances are you know a lot of people who would want to get you (or your assistant) to run an errand for them. Ensure that you communicate clearly the type of services you have, and research errand services in your area in order to come up with competitive rates.
Crafts or Floral Services. Have you always been into arts & crafts? Maybe it's time to turn your hobby into a money-making venture. You can capitalize on special occasions when you offer your custom-made crafts—such as souvenirs or tokens for parties, weddings and anniversaries, table centerpiece, knick-knacks and so on.
Gift Baskets. Creating a gift basket is not costly. Yet people are willing to pay a high price for these gift baskets most especially during holidays and birthday season. Other occasions that call for gift baskets are bridal showers and special company occasions.
Direct Selling. You could also work from home by taking part in businesses that have already been established. This can work for you because the products that you will be selling are already popular. Note that this is a competitive area so you must hone those selling and marketing skills in order to stay on top.
Whatever work from home business venture you get into, you must remember to promote yourself and the best promotional activity is by doing quality work. When word goes around about you and if it reflects good on you, work will come knocking on your door. Work from home may not always be easy, but worth giving a try, if only for the chance of achieving work-life balance.


text:
Henry Grace
Henry Grace (March 20, 1907 – September 16, 1983) was an American set decorator. He won an Oscar and was nominated for twelve more in the category Best Art Direction.[1] As an actor, he had a role as Dwight D. Eisenhower, whom he strongly resembled, in The Longest Day.
For other people, see Henry Grace (disambiguation).
(1907-03-20)March 20, 1907
September 16, 1983(1983-09-16) (aged 76)
Grace won an Academy Award for Best Art Direction and was nominated for twelve more:
Gigi (1958)[2]
Blackboard Jungle (1955)[3]
North by Northwest (1959)[4]
Cimarron (1960)[5]
The Wonderful World of the Brothers Grimm (1962)[6]
Mutiny on the Bounty (1962)[6]
Period of Adjustment (1962)[6]
How the West Was Won (1962)[7]
Twilight of Honor (1963)[7]
The Unsinkable Molly Brown (1964)[8]
The Americanization of Emily (1964)[8]
A Patch of Blue (1965)[9]
Mister Buddwing (1966)[10]
"IMDb.com: Henry Grace - Awards". IMDb.com. Retrieved December 22, 2008.
"The 31st Academy Awards (1959) Nominees and Winners". oscars.org. Archived from the original on July 6, 2011. Retrieved August 21, 2011.
"The 28th Academy Awards (1956) Nominees and Winners". oscars.org. Archived from the original on July 6, 2011. Retrieved August 20, 2011.
"The 32nd Academy Awards (1960) Nominees and Winners". oscars.org. Archived from the original on July 6, 2011. Retrieved August 21, 2011.
"The 33rd Academy Awards (1961) Nominees and Winners". oscars.org. Retrieved August 22, 2011.
"The 35th Academy Awards (1963) Nominees and Winners". oscars.org. Retrieved August 23, 2011.
"The 39th Academy Awards (1967) Nominees and Winners". oscars.org. Retrieved September 4, 2011.
Henry Grace on IMDb
Henry Grace at AllMovie
Academy Award for Best Production Design
1927/1928: William Cameron Menzies
1929/1929: Cedric Gibbons
1929/1930: Herman Rosse
1930/1931: Max Rée
1931/1932: Gordon Wiles
1932/1933: William S. Darling
1934: Cedric Gibbons, Fredric Hope
1935: Richard Day
1937: Stephen Goosson
1938: Carl Jules Weyl
1939: Lyle R. Wheeler
/ Color separate
1940 (bw): Cedric Gibbons, Paul Groesse / (c): Vincent Korda
1941 (bw): Richard Day, Nathan Juran, Thomas Little / (c): Cedric Gibbons, Urie McCleary, Edwin B. Willis
1942 (bw): Richard Day, Joseph C. Wright, Thomas Little / (c): Richard Day, Joseph C. Wright, Thomas Little
1943 (bw): James Basevi, William S. Darling, Thomas Little / (c): Alexander Golitzen, John B. Goodman, Russell A. Gausman, Ira S. Webb
1944 (bw): Cedric Gibbons, William Ferrari, Paul Huldschinsky, Edwin B. Willis / (c): Wiard Ihnen, Thomas Little
1945 (bw): Wiard Ihnen, A. Roland Fields / (c): Hans Dreier, Ernst Fegté, Samuel M. Comer
1946 (bw): William S. Darling, Lyle R. Wheeler, Thomas Little, Frank E. Hughes / (c): Cedric Gibbons, Paul Groesse, Edwin B. Willis
1947–1956 renamed
- Set Decoration
1947 (bw): John Bryan, Wilfred Shingleton / (c): Alfred Junge
1948 (bw): Roger K. Furse, Carmen Dillon / (c): Hein Heckroth, Arthur Lawson
1949 (bw): Harry Horner, John Meehan, Emile Kuri / (c): Cedric Gibbons, Paul Groesse, Edwin B. Willis, Jack D. Moore
1950 (bw): Hans Dreier, John Meehan, Samuel M. Comer, Ray Moyer / (c): Hans Dreier, Walter Tyler, Samuel M. Comer, Ray Moyer
1951 (bw): Richard Day, George James Hopkins / (c): Cedric Gibbons, E. Preston Ames, Edwin B. Willis, F. Keogh Gleason
1952 (bw): Cedric Gibbons, Edward Carfagno, Edwin B. Willis, F. Keogh Gleason /(c): Paul Sheriff, Marcel Vertès
1953 (bw): Cedric Gibbons, Edward Carfagno, Edwin B. Willis, Hugh Hunt / (c): Lyle R. Wheeler, George Davis, Walter M. Scott, Paul S. Fox
1954 (bw): Richard Day / (c): John Meehan, Emile Kuri
1955 (bw): Hal Pereira, Tambi Larsen, Samuel M. Comer, Arthur Krams / (c): William Flannery, Jo Mielziner, Robert Priestley
1956 (bw): Cedric Gibbons, Malcolm F. Brown, Edwin B. Willis, F. Keogh Gleason / (c): Lyle R. Wheeler, John DeCuir, Walter M. Scott, Paul S. Fox
1957: Ted Haworth, Robert Priestley
1958: William A. Horning, E. Preston Ames, Henry Grace, F. Keogh Gleason
1959 (bw): Lyle R. Wheeler, George Davis, Walter M. Scott, Stuart A. Reiss / (c): William A. Horning (posthumous award), Edward Carfagno, Hugh Hunt
1960 (bw): Alexandre Trauner, Edward G. Boyle /(c): Alexander Golitzen, Eric Orbom (posthumous award), Russell A. Gausman, Julia Heron
1961 (bw): Harry Horner, Gene Callahan / (c): Boris Leven, Victor A. Gangelin
1962 (bw): Alexander Golitzen, Henry Bumstead, Oliver Emert /(c): John Box, John Stoll, Dario Simoni
1963 (bw): Gene Callahan / (c): John DeCuir, Jack Martin Smith, Hilyard M. Brown, Herman A. Blumenthal, Elven Webb, Maurice Pelling, Boris Juraga, Walter M. Scott, Paul S. Fox, Ray Moyer
1964 (bw): Vassilis Photopoulos /(c): Gene Allen, Cecil Beaton, George James Hopkins
1965 (bw): Robert Clatworthy, Joseph Kish /(c): John Box, Terence Marsh, Dario Simoni
1966 (bw): Richard Sylbert, George James Hopkins / (c): Jack Martin Smith, Dale Hennesy, Walter M. Scott, Stuart A. Reiss
1967: John Truscott, Edward Carrere, John W. Brown
1968: John Box, Terence Marsh, Vernon Dixon, Ken Muggleston
1969: John DeCuir, Jack Martin Smith, Herman A. Blumenthal, Walter M. Scott, George James Hopkins, Raphaël Bretton
1970: Urie McCleary, Gil Parrondo, Antonio Mateos, Pierre-Louis Thévenet
1971: John Box, Ernest Archer, Jack Maxsted, Gil Parrondo, Vernon Dixon
1972: Rolf Zehetbauer, Jurgen Kiebach, Herbert Strabel
1973: Henry Bumstead, James W. Payne
1974: Dean Tavoularis, Angelo P. Graham, George R. Nelson
1975: Ken Adam, Roy Walker, Vernon Dixon
1976: George C. Jenkins, George Gaines
1977: John Barry, Norman Reynolds, Leslie Dilley, Roger Christian
1978: Paul Sylbert, Edwin O'Donovan, George Gaines
1979: Philip Rosenberg, Tony Walton, Edward Stewart, Gary J. Brink
1980: Pierre Guffroy, Jack Stephens
1981: Norman Reynolds, Leslie Dilley; Michael D. Ford (set)
1982: Stuart Craig, Robert W. Laing; Michael Seirton (set)
1983: Anna Asp, Susanne Lingheim
1984: Patrizia von Brandenstein; Karel Černý (set)
1985: Stephen B. Grimes; Josie MacAvin (set)
1986: Gianni Quaranta, Brian Ackland-Snow; Brian Savegar, Elio Altramura (set)
1987: Ferdinando Scarfiotti; Bruno Cesari, Osvaldo Desideri (set)
1988: Stuart Craig; Gérard James (set)
1989: Anton Furst; Peter Young (set)
1990: Richard Sylbert (art); Rick Simpson (set)
1991: Dennis Gassner (art); Nancy Haigh (set)
1992: Luciana Arrighi (art); Ian Whittaker (set)
1993: Allan Starski (art); Ewa Braun (set)
1994: Ken Adam (art); Carolyn Scott (set)
1995: Eugenio Zanetti (art)
1996: Stuart Craig (art); Stephenie McMillan (set)
1997: Peter Lamont (art); Michael D. Ford (set)
1998: Martin Childs (art); Jill Quertier (set)
1999: Rick Heinrichs (art); Peter Young (set)
2000: Timmy Yip (art)
2001: Catherine Martin (art); Brigitte Broch (set)
2002: John Myhre (art); Gordon Sim (set)
2003: Grant Major (art); Dan Hennah and Alan Lee (set)
2004: Dante Ferretti (art); Francesca Lo Schiavo (set)
2005: John Myhre (art); Gretchen Rau (set; posthumous award)
2006: Eugenio Caballero (art); Pilar Revuelta (set)
2008: Donald Graham Burt (art) and Victor J. Zolfo (set)
2009: Rick Carter and Robert Stromberg (art), Kim Sinclair (set)
2010: Robert Stromberg (art) and Karen O'Hara (set)
2011: Dante Ferretti (art) and Francesca Lo Schiavo (set)
2012: Rick Carter (art) and Jim Erickson (set)
2013: Catherine Martin (art) and Beverley Dunn (set)
2014: Adam Stockhausen (art) and Anna Pinnock (set)
2015: Colin Gibson (art) and Lisa Thompson (set)
2016: David Wasco (art) and Sandy Reynolds-Wasco (set)
2017: Paul Denham Austerberry (art) and Shane Vieau and Jeff Melvin (set)
2018: Hannah Beachler (art) and Jay Hart (set)