text:
Philatelia.Net / French revolution / Plots /
The directory «Plots»
Victories of revolution army
The French Revolutionary Wars began in 1792. France declared war on Austria on 20 April 1792. But Prussia and other powers had allied themselves with Austria in the expectation of conflict, and thus France faced a coalition and not a single power at the moment when the "emigration", the ferment of the Revolution, and want of material and of funds had thoroughly disorganised her army.
The army behaved badly in the first engagements. Near Lille (29 April) the French soldiers fled at sight of the Austrian outposts and murdered their general Théobald Dillon, whom they accused of betraying them. The commanders-in-chief of the armies became political "suspects"; and before a serious action had been fought, the three armies commanded respectively by Rochambeau, Lafayette and Luckner had been reorganized into two commanded by Dumouriez and Kellermann. Thus the disciplined soldiers of the Allies had apparently good reason to consider the campaign would be easy.
On the Rhine, a combined army of Prussians, Austrians, Hessians and émigrés under the Duke of Brunswick was formed for the invasion of France, flanked by two smaller armies on its right and left, all three being under the supreme command of King Frederick William II of Prussia. In the Southern Netherlands, plans called for the Austrians to besiege Lille, and in the south the Piedmontese also took the field.
The first step was the issue (25 July) of the Brunswick Manifesto, a proclamation which, couched in terms in the last degree offensive to the French nation, generated the spirit that was afterwards to find expression in the "armed nation" of 1793–1794, and sealed the fate of King Louis. It was issued against the advice of Brunswick himself, whose signature appeared on it; the duke, a model sovereign in his own principality, sympathised with the constitutional side of the French Revolution, while as a soldier he had no confidence in the success of the enterprise.
After completing its preparations in the leisurely manner of the previous generation, his army crossed the French frontier on 19 August 1792. The Allies readily captured Longwy and slowly marched on to Verdun, which appeared more indefensible even than Longwy. The commandant there, Colonel Beaurepaire, shot himself in despair, and the place surrendered on 3 September 1792.
Brunswick now began his march on Paris and approached the defiles of the Argonne. But Dumouriez, who had been training his raw troops at Valenciennes in constant small engagements, with the purpose of invading Belgium, now threw himself into the Argonne by a rapid and daring flank march, almost under the eyes of the Prussian advance guard, and barred the Paris road, summoning Kellermann to his assistance from Metz. Kellermann moved but slowly, and before he arrived the northern part of the line of defence had been forced. Dumouriez, undaunted, changed front so as to face north, with his right wing on the Argonne and his left stretching towards Châlons, and in this position Kellermann joined him at Sainte-Menehould on 19 September 1792.
Brunswick meanwhile had passed the northern defiles and had then swung round to cut off Dumouriez from Châlons. At the moment when the Prussian manoeuvre was nearly completed, Kellermann, commanding in Dumouriez's momentary absence, advanced his left wing and took up a position between Sainte-Menehould and Valmy. The result was the world-renowned Cannonade of Valmy (20 September 1792). Kellermann's infantry, nearly all regulars, stood steady. The French artillery justified its reputation as the best in Europe, and eventually, with no more than a half-hearted infantry attack, the duke broke off the action and retired.
This seemingly minor engagement proved the turning point of the campaign and a watershed in world history. Ten days later, without firing another shot, the invading army began its retreat. Dumouriez did not press the pursuit seriously; he occupied himself chiefly with a series of subtle and curious negotiations which, with the general advance of the French troops, brought about the complete withdrawal of the enemy from the soil of France.
Meanwhile, the French forces in the south had driven back the Piedmontese and had conquered Savoy and Nice.
Another French success was the daring expedition into Germany made by Custine from Alsace. Custine captured Mainz on 21 October 1792 and penetrated as far as Frankfurt. In the north, the Austrian siege of Lille had completely failed, and Dumouriez now resumed his interrupted scheme for the invasion of the Netherlands. Controlling enormously superior forces, he made his advance late in the season and surprised the Austrians. On 6 November he won the first great victory of the war at Jemappes near Mons and, this time advancing boldly, he overran the whole country from Namur to Antwerp within a month.
Albania, 1989, Arc de Triomphe
Belgium, 1993, Battle of Neerwinden (1793)
Central African Republic, 1989, General Demouriez and Battle of Jemappes
Comoren Islands, 1989, General Kellerman and Battle of Valmy
France, 1971, Battle of Valmy
France, 1989, General Kellermann
France, 1995, Statue of Volontaire de l'an II in Remiremont
France, 2006, Valmy
Ghana, 1989, Departure of the volonteers in 1792
Madagaskar, 1989, La Marseillaise
France, 1971.09.18, Valmy. Battle of Valmy


interested (anyone who develops software should be).
survey and return it as soon as possible to aid us in this matter.
Information you provide will be forwarded to the patent office.
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Ensure to grab your copy to be published this Sunday on 28 April in Home & Garden Checklist 2019.
Green-tech has announced the dates for their next two Chemical Workshops - Training the Trainer.
Toro of BALI Registered Affiliate Reesink Turfcare machines ticked boxes for the council.
Ensure you've submitted content for BALI's Summer edition of Landscape News before 10 May 2019.
Marley decking chosen for the refurbishment and upgrade of the lodge decking area.
Rural Zimbabwe comes to Chelsea in Show Garden designed by BALI Registered Designer Jilayne Rickards.


text:
Home / Imagine Otherwise
Imagine Otherwise
On Asian Americanist Critique
Book Pages: 232 Illustrations: Published: April 2003
Author: Kandice Chuh
American Studies, Asian American Studies, Theory and Philosophy > Race and Indigeneity
Imagine Otherwise is an incisive critique of the field of Asian American studies. Recognizing that the rubric "Asian American" elides crucial differences, Kandice Chuh argues for reframing Asian American studies as a study defined not by its subjects and objects, but by its critique. Toward that end, she urges the foregrounding of the constructedness of "Asian American" formations and shows how this understanding of the field provides the basis for continuing to use the term "Asian American" in light of—and in spite of—contemporary critiques about its limitations.
Drawing on the insights of poststructuralist theory, postcolonial studies, and investigations of transnationalism, Imagine Otherwise conceives of Asian American literature and U.S. legal discourse as theoretical texts to be examined for the normative claims about race, gender, and sexuality that they put forth. Reading government and legal documents, novels including Carlos Bulosan's America Is in the Heart, John Okada's No-No Boy, Chang-rae Lee's A Gesture Life, Ronyoung Kim's Clay Walls, and Lois Ann Yamanaka's Blu's Hanging, and the short stories "Immigration Blues" by Bienvenido Santos and "High-Heeled Shoes" by Hisaye Yamamoto, Chuh works through Filipino American and Korean American identity formation and Japanese American internment during World War II as she negotiates the complex and sometimes tense differences that constitute 'Asian America' and Asian American studies.
"Chuh's award-winning strategy of concretizing this space of enquiry and solidifying it, diversifying it, enriching it, through a specifically and critically Americanist lens is to revisit various … narratives of Asian Americana, while drawing on theoretical perspectives from American-Continental philosophy, critical race theory, legal theory, and feminist jurisprudential scholarship." — Kyoo Lee , Comparatist
"Kandice Chuh's Imagine Otherwise: On Asian Americanist Critique offers the most explicit and sustained interrogation of disciplinarity and interdisciplinarity in Asian American studies. . . . The most original and provocative application of the transnational appears in Chuh's consideration of Japanese American history and literary texts." — Laura Hyun Yi Kang, Feminist Studies
"Imagine Otherwise compellingly reimagines the goals and paradigms of Asian American studies. . . . Chuh demonstrates her argument through rich, interdisciplinary readings of literary texts, historical and legal documents, and academic rubrics." — Yoonmee Chang , American Literature
"Kandice Chuh argues that in the current study of Asian Americans, the critique of social inequality must overcome the impossible insistence on a uniform ethnic subject. She performs a daring deconstruction of the recurrence to ideas of authenticity and identity, discusses the pitfalls of essentialized concepts of 'activism' and 'community,' and encourages us to put the case of Asian Americans towards a more general critique of racialized U.S. society. Her intervention challenges us to think differently, to 'imagine otherwise.'"
— Lisa Lowe, author of Immigrant Acts: On Asian American Cultural Politics
"Imagine Otherwise is a provocative work. It questions the terms in which Asian American studies have been understood and offers a set of exciting theoretical alternatives, each of which is substantiated by close readings of literary texts. Our understanding of Asian American subjectivity is significantly enhanced in the process." — David Palumbo-Liu, author of Asian/American: Historical Crossings of a Racial Frontier
Kandice Chuh is Professor of English, Graduate Center, City University of New York. She is coeditor of Orientations: Mapping Studies in the Asian Diaspora, published by Duke University Press.
Preface: Imagine Otherwise ix
Introduction: On Asian Americanist Critique 1
1. Against Uniform Subjectivity: Remembering "Filipino America" 31
2. Nikkei Internment: Determined Identities/Undecidable Meanings 58
3. "One Hundred Percent Korean": On Space and Subjectivity 85
4. (Dis)Owning America 112
Conclusion: When Difference Meets Itself 147
Winner, 2003 Lora Romero First Book Prize, American Studies Association
Asian and Asian American studies emerged, respectively, from Cold War and social protest ideologies. Yet, in the context of contemporary globalization, can...
Postcolonial Grief
In Postcolonial Grief Jinah Kim explores the relationship of mourning to transpacific subjectivities, aesthetics, and decolonial politics since World...
The Difference Aesthetics Makes
In The Difference Aesthetics Makes cultural critic Kandice Chuh asks what the humanities might be and do if organized around what she calls "illiberal...
The Intimacies of Four Continents
In this uniquely interdisciplinary work, Lisa Lowe examines the relationships between Europe, Africa, Asia, and the Americas in the late eighteenth- and...

redpajama_set_name: RedPajamaCommonCrawl


text:
use parser;
use filehandler;
use model;
use std::env;

#[test]
fn test_parse_demofile() {
  let mut currentWD = env::current_dir().unwrap().display().to_string();
  currentWD.push_str("/doc/samples/simple.sjs");

  let opts = model::CommandlineOptions {
    filename: currentWD.clone(),
    target_language:model::TargetLanguage::JQUERY,
    target_folder:"".to_string(),
    debug:false,
  };

  let mut model = model::GeneralModel {
    options:&opts,
    code:"".to_string(),
  };

  filehandler::read_file(&model.options.filename, &mut model.code);

  let mut p:parser::Parser = parser::Parser::new();

  let result = p.parse(&mut model);

  println!("{:?}", result);

  // Testfaelle einbauen:
  // panic!("TEST");
}

#[test]
fn test_is_whitespace_or_newline() {
  let success = parser::Parser::is_whitespace_or_newline(&' ');
  let error = parser::Parser::is_whitespace_or_newline(&'/');

  assert!(success);
  assert!(!error);
}

#[test]
fn test_is_valid_name_character() {
  let success = parser::Parser::is_valid_name_character(&'u');
  let error = parser::Parser::is_valid_name_character(&'{');

  assert!(success);
  assert!(!error);
}

redpajama_set_name: RedPajamaGithub


Topic: Power line tunnels and underground transformers?
May I ask - has consideration been given to producing graphics for these? They are both features of the new stable release of Standard, and the author of the code is Pak128.Britain's own Kieron.
Since much electrical power transmission in the UK is underground, it would be worthwhile considering these, at least the power line tunnels. I don't know how common that underground transformers are in the UK.
Re: Power line tunnels and underground transformers?
Small industries would usually have no visible transformer - graphics would probably be very plain for this, as they would for power line tunnels in general.
Perhaps only a consumer substation for industries allowed underground, in that case?
I certainly coded this up a few weeks ago, but maybe I didn't include in SVN?
fabio work on new underground powerlines.
Yes, you could check Pak 128 svn r1077.
Tunnel object and hidden underground conduits for the underground part.
Splendid! I shall add these to the Experimental version when the latest Standard commits are merged in.
I must admit the graphics are basic (e.g. there are still pylon graphics underground) but at least the function is there.
Hmm - any volunteers to draw actual tunnels...?
If you guys would like to use / adapt my underground power conduits, feel free to help yourself!
You can find .png and Gimp .xcf, as well as .dat, in SVN at r1077 (Pak128, of course!).
Are the pylons the same as the old ones (with a new graphic for tunnel entrance)? If so they will be easy to adapt as I just recoloured the old pak128 graphics for pak128.Britain.
Same pylons for a while.
By the way, I also edited the power lines pylons using offsets where they were truncated for tile reasons.
Tunnel entrances might be slightly improved over the next few days, though (see the other thread).


Well, we suppose this counts as pro gress: Responding to cuts in his $7.2 million budget, Bronx Borough President Adolfo Carrion recently laid off 16 of his 77 staffers.
But what on earth do the other 61 do?
Borough presidents, after all, haven't had any real power since 1989, when a lawsuit abolished the Board of Estimate.
The Post last August revealed that Carrion and Staten Island President James Molinaro had 11 official cars each, while Brooklyn's Marty Markowitz had seven.
And all of them have bloated, multi-million-dollar operating budgets – doling out cash to their favorites.
This is at a time when budget pressures are forcing City Hall to ax an entire class of police recruits.
So, let's be frank: Borough presidents were a useless annoyance back when times were flush. Now, wasting one more cent on them is a scandal.


Okay , so I previously posted on here re sat Nav locking, asking for any suggested alternatives to the retro fitting of the BMW lockable cradle, eventually no doubt I will end up handing over my hard earned £48 to my friendly BMW dealer for the sat Nav lock that should have been fitted from standard.
I think I have come up with a decent alternative in the meantime, to ensure I'm able to keep my sat nav where it should be, and not in the pocket of some opportunist scumbag.
I would only put my faith in my solution for short stops eg fuel fill ups, coffee stops etc, but to be honest even if I had the locking cradle fitted I wouldn't leave my Nav 6 on my bike in the car park at a big bike meet eg, BSB , MotoGP etc.
Seems a great Idea, But after wasting my cash on the rubbish wunderlich attempt at a sat - nav lock. I decided the easiest solution was just take the thing off and put it in my pocket.
Do not get me wrong your Idea seems sound and extremely cheap. And could work for others, my only reservation being if left in the cradle a half determined thief could very easily just rip the whole thing off. Hence my solution is to have it in my pocket......If its not on the bike they cannot nick it..
If its not on the bike they cannot nick it..
True, they'll just nick the whole bike then..
At least you'd know where you were going....whilst walking..
It actually takes me longer to operate the quick release and remove the tank bag to refuel, than remove the sat nav.
I had my bike nicked - luckily got it back - thanks Biketrac.
But they levered out the satnav - even though it was in a locking BMW cradle!
anyway, I landed up getting a new Sat nav paid for by the insurance company.
Best way way for ultimate security take it off the bike with you.
I've got a brand new BMW locking cradle, some standoffs and longer screws.
Could be up for sale as Im not so sure I'll be fitting it.


text:
Q: FTB Server Friends can't connect I am having a problem where I can connect to my FTB Server with locahost and also with my internal ip address. However, my friends cannot connect with my external ip. I have watched numerous videos about how to port forward and how to set the server up, but my friends still cannot connect.

A: I don't know what you did exactly to activate port forwarding but my guess is that the description you used does not mention that some routers have an internal firewall too where you have to open the port aswell.
In addition to that, you might need to open the port in your local (PC) firewall too.
(This might also be the case if you use a VPN, like Hamachi which was already mentioned by Flaunting.)

A: Either follow the port forwarding route and make sure your router is properly port forwarding or the alternative is to use LogMeIn's Hamachi client which will create an artificial lan connection and your friends will be able to coonect to your internal IP.
The link to instructions for this are Here
Hamachi is free and i think pretty easy to use.

redpajama_set_name: RedPajamaStackExchange


text:
<?xml version="1.0" encoding="utf-8"?>
<LinearLayout xmlns:android="http://schemas.android.com/apk/res/android"
    android:orientation="vertical"
    android:layout_width="match_parent"
    android:layout_height="match_parent"
    android:background="#ffffff">

    <ScrollView
        android:layout_height="wrap_content"
        android:layout_width="wrap_content">

        <LinearLayout
            android:layout_height="wrap_content"
            android:layout_width="wrap_content"
            android:orientation="vertical"
            android:background="#ffffff">

            <TextView
                android:layout_width="match_parent"
                android:layout_height="wrap_content"
                android:text="Notification"
                android:id="@+id/textView_notification"
                android:background="@color/holo_blue_dark"
                android:textColor="@color/white"
                android:paddingLeft="15dp"
                android:paddingRight="10dp"
                android:paddingTop="3dp"
                android:paddingBottom="3dp"
                android:textSize="13dp"
                android:textStyle="bold" />

            <RelativeLayout
                android:layout_height="wrap_content"
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                android:paddingTop="10dp"
                android:paddingLeft="10dp"
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                android:paddingBottom="10dp"
                android:layout_marginLeft="10dp"
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                android:id="@+id/relativeLayout_send_notification"
                android:background="@drawable/list_divider">

                <TextView
                    android:layout_width="wrap_content"
                    android:layout_height="wrap_content"
                    android:textAppearance="?android:attr/textAppearanceLarge"
                    android:text="Send Notifications"
                    android:id="@+id/textView_send_notification"
                    android:textSize="17dp"
                    android:layout_alignParentTop="true"
                    android:layout_alignParentLeft="true"
                    android:layout_alignParentStart="true" />

                <TextView
                    android:layout_width="wrap_content"
                    android:layout_height="wrap_content"
                    android:textAppearance="?android:attr/textAppearanceLarge"
                    android:text=" "
                    android:textColor="@android:color/darker_gray"
                    android:textSize="12dp"
                    android:layout_below="@+id/textView_send_notification"
                    android:id="@+id/textView321" />

                <Switch
                    android:layout_width="wrap_content"
                    android:layout_height="wrap_content"
                    android:id="@+id/switch_notification"
                    android:layout_toRightOf="@+id/textView_send_notification"
                    android:layout_alignParentEnd="true" />

                <TextView
                    android:layout_width="wrap_content"
                    android:layout_height="wrap_content"
                    android:textAppearance="?android:attr/textAppearanceLarge"
                    android:text="Turn ON/OFF the notification of this application"
                    android:textColor="@android:color/darker_gray"
                    android:textSize="12dp"
                    android:id="@+id/textView323"
                    android:layout_alignParentBottom="true"
                    android:layout_alignParentLeft="true"
                    android:layout_alignParentStart="true" />
            </RelativeLayout>

            <TextView
                android:layout_width="match_parent"
                android:layout_height="wrap_content"
                android:text="Timetable"
                android:id="@+id/textView_timetable"
                android:background="@color/holo_blue_dark"
                android:textColor="@color/white"
                android:paddingLeft="15dp"
                android:paddingRight="10dp"
                android:textSize="13dp"
                android:textStyle="bold"
                android:paddingTop="3dp"
                android:paddingBottom="3dp" />

            <RelativeLayout
                android:layout_height="wrap_content"
                android:layout_width="match_parent"
                android:orientation="vertical"
                android:paddingTop="10dp"
                android:paddingLeft="10dp"
                android:paddingRight="10dp"
                android:paddingBottom="10dp"
                android:layout_marginLeft="10dp"
                android:layout_marginRight="10dp"
                android:id="@+id/relativeLayout_timetable"
                android:background="@drawable/list_divider">

                <TextView
                    android:layout_width="wrap_content"
                    android:layout_height="wrap_content"
                    android:textAppearance="?android:attr/textAppearanceLarge"
                    android:text="Timetable Notifications"
                    android:id="@+id/textView_timetable_share"
                    android:textSize="17dp"
                    android:layout_alignBaseline="@+id/switch_timetable"
                    android:layout_alignBottom="@+id/switch_timetable"
                    android:layout_alignParentLeft="true"
                    android:layout_alignParentStart="true" />

                <TextView
                    android:layout_width="wrap_content"
                    android:layout_height="wrap_content"
                    android:textAppearance="?android:attr/textAppearanceLarge"
                    android:text=" "
                    android:textColor="@android:color/darker_gray"
                    android:textSize="12dp"
                    android:layout_below="@+id/textView_timetable_share"
                    android:id="@+id/textView325" />

                <Switch
                    android:layout_width="wrap_content"
                    android:layout_height="wrap_content"
                    android:id="@+id/switch_timetable"
                    android:layout_toRightOf="@+id/textView_timetable_share"
                    android:layout_alignParentEnd="true" />

                <TextView
                    android:layout_width="wrap_content"
                    android:layout_height="wrap_content"
                    android:textAppearance="?android:attr/textAppearanceLarge"
                    android:text="Turn ON/OFF the Timetable Notification"
                    android:textColor="@android:color/darker_gray"
                    android:textSize="12dp"
                    android:id="@+id/textView324"
                    android:layout_alignTop="@+id/textView325"
                    android:layout_toRightOf="@+id/textView325"
                    android:layout_toEndOf="@+id/textView325" />
            </RelativeLayout>

        </LinearLayout>
    </ScrollView>
</LinearLayout>

    <!--<LinearLayout
    android:layout_height="wrap_content"
    android:layout_width="match_parent"
    android:orientation="vertical"
    android:paddingTop="10dp"
    android:paddingLeft="10dp"
    android:paddingRight="10dp"
    android:paddingBottom="10dp"
    android:layout_marginLeft="10dp"
    android:layout_marginRight="10dp"
    android:id="@+id/linearlayout_content_notification">
    <TextView
        android:layout_width="wrap_content"
        android:layout_height="wrap_content"
        android:textAppearance="?android:attr/textAppearanceLarge"
        android:text="Content settings"
        android:id="@+id/textView_content_notification" />
    <TextView
        android:layout_width="wrap_content"
        android:layout_height="wrap_content"
        android:textAppearance="?android:attr/textAppearanceLarge"
        android:text="Set the content that appear in notifications"
        android:textColor="@android:color/darker_gray"
        android:textSize="12dp"        />
    </LinearLayout>-->

    <!--<LinearLayout
            android:layout_height="wrap_content"
            android:layout_width="match_parent"
            android:orientation="vertical"
            android:paddingTop="10dp"
            android:paddingLeft="10dp"
            android:paddingRight="10dp"
            android:paddingBottom="10dp"
            android:layout_marginLeft="10dp"
            android:layout_marginRight="10dp"
            android:id="@+id/linearlayout_add_parameter">
            <TextView
                android:layout_width="wrap_content"
                android:layout_height="wrap_content"
                android:textAppearance="?android:attr/textAppearanceLarge"
                android:text="Add Parameter"
                android:id="@+id/textView_add_parameter" />
            <TextView
                android:layout_width="wrap_content"
                android:layout_height="wrap_content"
                android:textAppearance="?android:attr/textAppearanceLarge"
                android:text="Assign the right to other to read your timetable"
                android:textColor="@android:color/darker_gray"
                android:textSize="12dp"        />
        </LinearLayout>-->


Dakota County Attorney James Backstrom announced Sept. 24 that 17-year-old Trashaun Morris, from St. Paul, was certified to stand trial as an adult for allegedly shooting to death another young man in March outside an Inver Grove Heights movie theater.
Morris was charged as an adult that same day with second-degree murder with intent to kill, second-degree murder without intent to kill while committing a felony, third-degree murder while perpetrating an eminently dangerous act and evincing a depraved mind, and first- and second-degree riot.
The slew of charges are for the March 24 shooting that killed a 19-year-old St. Paul man, Billy Ray Robles.
Morris' bail was set at $500,000. The maximum sentence for second-degree murder is 40 years in prison.
According to the criminal complaint against him, on March 24 around 1:30 a.m., Inver Grove Heights police officers were dispatched to the parking lot of the AMC Theatre in the 5500 block of Bishop Avenue on a report of a fight, shots fired and people leaving the scene — it was later reported more than 40 people fled prior to the arrival of police.
When officers arrived, they were directed to a party bus where they found a man who'd been shot twice — he was later identified as Robles, who died from a gunshot wound to his chest.
According to the complaint, the investigation determined a large number of people spent the night on a party bus that had departed earlier from the theater parking lot. Some were members of what was described as "east side" and "west side" groups. The groups argued throughout the night while on the bus.
When the bus returned the groups exited, and witnesses said the west side group started chasing the other group. One witness described two members of the east side group turning and firing guns in the direction of the west side group. The complaint says one of the shooters was later identified as Morris, who allegedly identifies as a Payne Block Killer, a clique within the east side group.
The witness was shot in the ankle while walking towards a car. He left the scene prior to police arriving, but police were able to stop the vehicle he was in on Highway 52 near Butler Avenue. The witness was transported to Regions Hospital for treatment before being released.
Another witness, according to the complaint, said when the bus returned to the parking lot he saw a person he knew as "Tre Tre," a nickname Morris goes by, turn and shoot toward the other group.
According to the criminal complaint, investigators looked at Facebook profiles and it was determined that "Tre Tre" was Morris. A photo lineup was complied and the second witness identified Morris as the east side group member who shot at the west side group.
A third witness associated with the west side group was on the bus when it returned and told police someone punched him in the face.
When the driver told everyone to get off the bus, this third witness said that along with the second witness, Robles and a couple other young men chased members of the east side group through the parking lot. As they were chasing the group, one of the east side members started shooting toward them.
This third witness said the shooter had a white towel wrapped around the gun and fired five or six times. The witness identified Morris as the shooter as well.
Police watched cell phone video from the incident that allegedly showed Morris in the distance facing the camera, holding what appeared to be a handgun wrapped in white cloth. A voice on the video was heard yelling "bro stop," which witnesses said was Robles, who was standing near the first witness at the time of the video.
The video evidence and distribution of various shell casings at the scene were consistent with witness statements that Morris was allegedly shooting a 9 mm in the direction of the first witness and a group of west siders, including Robles.
Morris' next court appearance is set for Oct. 18 in Hastings.


New materials last much longer than the original design!
Speakers were a perfect fit and sound fantastic. Excellent quality , shipping and customer service. Highlest recommendation .
Awesome!!! Had my BA A100's since the early eighties, and they have never sounded better. Easy five minute fix, 4 screws, two wires. Never taken the time to write a review before, but I am one happy customer!!
A woofer failed and I was very happy to get this replacement for my old BA speakers. Sounds great!
Purchased a pair to replace the original woofers in my Boston Acoustics A-150s. Initially I tried the Simply Speaker foam repair kit which worked very well, but as it turns out I also had one badly damaged coil. I opted for these replacements which are superior in construction to the original by a wide margin. Dropped right in too. The re-assembled A-150s impedance measured just about spot-on with the old ones and the performance, lightly-loaded or with maximum thundering bass is outstanding. Clear, sharp sound all the way to the lowest notes that the A-150 was built for. They are well- matched for the original crossovers. I like them so much, I bought the smaller woofers also for my A-60s with equal results.
SEEM TO BE DIRECT REPLACEMENT WOOFERS AND SOUND JUST GREAT! SHIPPING TIME WAS GOOD ALSO.
I have purchased from Simply Speakers a couple of times. Each time my order has been processed quickly and correctly. I called and these were the speakers the salesperson recommended would work.
Worth the money. Easy to replace My Boston Acoustic speakers sound amazing again!
Received the woofers, replaced them. Speakers sound great. These speakers are about 30-35 years old and still sound great.
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McAllister & Quinn client Port of South Louisiana, along with the World Trade Center of New Orleans, Greater New Orleans, Inc., and the River Region Chamber of Commerce, hosted the Global Outreach for U.S. Exporters Forum on October 29, 2014, to assist exporters in understanding how the Export-Import Bank of the United States (Ex-Im Bank) and other governmental programs and resources can help increase their international sales. Participants attended discussions in which panelists described how their companies use these programs to grow their business, and agency officials explained how their products and services can help business owners expand their export opportunities.
Global Access is an initiative by the Ex-Im Bank dedicated to increasing the number of businesses exporting goods and services to maintain and create U.S. jobs. Global Access is supported by a variety of businesses, financial and government partners, including the Commerce Department, U.S. Trade Representatives, Small Business Administration, U.S. Chamber of Commerce, National Association of Manufacturers (NAM), PNC, Wells Fargo, Bank of America, Merrill Lynch, HSBC Bank USA, N.A., The Wall Street Journal, and FedEx.
The Exporter Forum is a sponsored event designed to assist exporters in understanding how the Ex-Im Bank and other governmental programs and resources can help increase their international sales.


text:
Effects of D-002, a mixture of high molecular weight beeswax alcohols, on patients with nonalcoholic fatty liver disease
Korean J Intern Med. 2013;28(4):439-448
Korean J Intern MedJournal ArchiveKorean J Intern Med. 2013;28(4)
Publication date (electronic) : 2013 July 01
doi : https://doi.org/10.3904/kjim.2013.28.4.439
José Illnait1, Iván Rodríguez2, Sarahí Mendoza1, Yolanda Fernández2, Rosa Mas1, Mirtha Miranda2, Jesús Piñera2, Julio César Fernández1, Meilis Mesa2, Lilia Fernández1, Daisy Carbajal1, Rafael Gámez1
1Centre of Natural Products, National Centre for Scientific Research, Havana, Cuba.
2Surgical Medical Research Centre, National Centre for Scientific Research, Havana, Cuba.
Correspondence to Sarahí Mendoza, M.D. Centre of Natural Products, National Centre for Scientific Research, 198 St, 19 and 21 Ave, Atabey, Playa, Havana, Cuba. Tel: +53-7-271-4225, Fax: +53-7-273-6837, sarahi.mendoza@cnic.edu.cu
Received 2012 August 23; Revised 2013 March 14; Accepted 2013 May 10.
Background/Aims
Nonalcoholic fatty liver disease (NAFLD) is intimately related to insulin resistance and ranges from a benign course to liver fibrosis and cirrhosis. NAFLD management mainly involves dietary modification and weight loss. Although no fully successful pharmacological intervention is available, alternative therapies to treat NAFLD have shown promising results. Experimental studies have shown that D-002, a mixture of beeswax alcohols with antioxidant effects, is hepatoprotective. The aim of this study was to investigate the efficacy and safety of D-002 in patients with NALFD.
Fifty patients with NAFLD were randomized to receive a placebo or D-002 (100 mg/day) for 24 weeks. The primary endpoint was a significant ultrasonography-detected reduction of liver fat infiltration versus a placebo. Secondary endpoints were decreases in the homeostatic model assessment (HOMA) index, insulin levels, serum liver enzymes, increases in plasma total antioxidant status (TAS) and improved clinical symptoms versus the placebo recipients.
At randomization, all indicators were comparable in both groups. At study completion, seven (28.0%) D-002-patients, but none of the placebo recipients, exhibited a normal liver echo pattern on ultrasonography (p < 0.01). Also, D-002 significantly reduced (p < 0.01 vs. baseline and placebo) the HOMA index and insulin levels and increased the TAS, but did not affect other parameters. The proportion of D-002-patients (12/25, 48.0%) showing symptom improvement was higher (p < 0.001) than that of the placebo group (1/25, 4.0%). The treatment was safe and well tolerated. Three patients in each group withdrew from the study.
D-002 (100 mg/day) improved ultrasonographic findings, indicators of insulin resistance, plasma TAS and clinical evolution on NAFLD patients. Further studies, however, are needed to confirm these results.
Keywords: D-002; Beeswax; Non-alcoholic fatty liver disease; Fatty liver; Insulin resistance
Nonalcoholic fatty liver disease (NAFLD), a common liver condition, is characterized by excessive accumulation of hepatic fat in the absence of significant alcohol consumption, and has been associated with insulin resistance (IR) [1-4]. Histologically, NAFLD accounts for the fat accumulation, mainly triglycerides (TG), into the hepatocyte cytoplasm (5% to 10% of the organ weight) [4,5].
The prevalence of NAFLD ranges from 10% to about 83%, depending on the population and research criteria, and it is overrepresented in diabetics, the obese, and females [1-4], although it may be also present in nonobese and nondiabetic subjects [6]. NAFLD generally follows a benign course and remains stable for years, but many undiagnosed cases may evolve to nonalcoholic steatohepatitis (NASH), liver fibrosis and cryptogenic liver cirrhosis [1-4].
NAFLD management involves dietary modification and weight loss [6-9]. Although some treatments (insulin sensitizers, antioxidants, lipid-lowering drugs, and ursodeoxycholic acid, among others), have proven beneficial in patients with NFALD, no fully successful pharmacological intervention is available [1,6-12].
In the search for effective and safe alternative therapies, the effects of some natural products on NAFLD have been investigated. The use of n-3 polyunsaturated fatty acids (PUFA) (2 g/day) from seal oils has proven to safely and effectively improve symptoms and normalize ultrasonographic features, as well as improve serum alanine aminotransferase (ALT) and lipid levels [13].
Also, p olicosanol, a mixture of high molecular weight alcohols isolated from sugarcane wax, has effectively treated IR in hyperlipidemic patients with fatty liver disease, significantly lowering the homeostatic model assessment (HOMA) index and total cholesterol (TC) and low density lipoprotein cholesterol (LDL) levels [14], consistent with the fact that octacosanol, its main component, attenuates the disrupted metabolism of hepatic reactive oxygen species linked with acute liver injury in carbon tetrachloride (CCl4)-intoxicated rats [15].
D-002, a substance purified from beeswax, contains a mixture of six of the higher aliphatic alcohols (C26, C26, C28, C30, C32, and C34) present in policosanol [16,17], but in different proportions, so that the major component of D-002 is triacontanol (C30), followed by octacosanol (C28) and docotriacontanol (C32). Oral administration of D-002 has been shown to produce antioxidant effects in experimental [18-20] and clinical studies [21-23], and to exhibit hepatoprotective effects in experimental models of CCl4-induced liver injury [24].
The effects of D-002 treatment in patients with NALFD, however, had not been previously investigated. This study was therefore performed to investigate the efficacy and safety of D-002 in patients with NALFD.
This study was a prospective, single-center, randomized, double-blind, placebo-controlled trial consisting of a screening visit and a 24-week treatment period.
The study protocol was approved by the Ethics Committee of the Medical Surgical Research Centre (Havana, Cuba), a Good Clinical Practices-accredited institution. The study was conducted in accordance with the principles of the Declaration of Helsinki. Patients were provided oral and written explanations of the nature of the trial and the treatment before they provided informed written consent (visit 1).
Eligible patients (visit 2) were randomized to D-002 (50 mg) or placebo tablets to be taken twice daily for 24 weeks, and were advised to follow a low-fat low-energy diet (50% carbohydrates, 20% protein, 30% fat) [25]. These dietary conditions were supposed to be followed from enrollment to the end of the study.
Subjects were seen at weeks 6, 12, 18, and 24 weeks (visits 3 to 6) of the treatment period. Physical examinations (determination of body mass index [BMI], blood pressure, and heart rate) and clinical assessments were conducted at each visit. Treatment compliance and adverse events (AEs) were controlled from visits 3 to 6, laboratory testing was performed at baseline and every 12 weeks, while hepatic fat infiltration was assessed by upper abdominal ultrasonography at baseline and week 24.
We enrolled patients of both sexes, aged 25 to 70 years, with a prior diagnosis of NAFLD and/or persistent increase in liver enzymes without excessive alcohol ingestion (weekly consumption ≥ 70 g in female, ≥ 40 g in male), confirmed by careful questioning of the patients and their primary doctors.
Enrolled patients were eligible for randomization if liver fat infiltration was confirmed by ultrasonography [26].
Exclusion criteria included overuse of alcohol, viral hepatitis, hemochromatosis, Wilson disease, autoimmune hepatitis, primary sclerosing cholangitis, or primary biliary cirrhosis; history of any other hepatic disorder, glucose values > 7 mmol/L (uncontrolled diabetes), inability to provide written informed consent; pregnancy, breastfeeding, and lack of effective birth control in women of child-bearing age. Also, patients who had had unstable angina, myocardial infarction, stroke or any serious AE within the 3 months prior to the study were excluded.
Moreover, patients were excluded if they were receiving any treatment that could influence liver function.
The study drugs (D-002 or identical placebo tablets) were taken twice per day (at lunch and dinner) for 24 weeks, so that treated patients received D-002 100 mg/day, a dose within the range approved in humans [27].
Randomization was computer-generated using blocks and a 1/1 randomization ratio. Treatments were given in identical coded packages accordingly. Consumption of drugs with recognized or suggested antioxidant, liver protective, or hepatotoxic effects was not allowed.
Treatment compliance was assessed by counting the remaining tablets with respect to those that should be consumed in each period. To be acceptable, ≥ 85% of the tablets scheduled for a period must have been consumed. Diet adhesion was followed by using special chart records filled by patients and reviewed by doctors, and by recording body weight at each visit.
Efficacy variables
The primary endpoint was a significant reduction in liver fat infiltration as assessed by ultrasonography, as compared to the placebo recipients.
The secondary endpoints were decreases in the HOMA index, insulin levels, and serum liver enzymes, increase in plasma total antioxidant status (TAS), and improved clinical symptoms as compared to the placebo.
Efficacy measurements
Ultrasonographic assessment
All patients underwent ultrasonography for liver steatosis after fasting for 10 to 12 hours. Ultrasound scans were performed by a trained operator who was blind to participants' group allocations.
Steatosis severity was scored using the following scale: 0 (normal echogenicity), 1 (mild), 2 (moderate), 3 (severe) [28]. Liver fat infiltration was considered mild when increased echogenicity plus augmented liver size was present, moderate if these two features were present plus sound attenuation, and severe if the walls of the portal vessels and the diaphragm were unseen.
Clinical evaluation
Patients were questioned about the evolution of their symptoms, such as abdominal discomfort or pain, abdominal bloating, and/or nausea. The changes were classified as follows: improved, worsened or unchanged.
Safety and tolerability
Data from the physical examination (determination of bodyweight, BMI, pulse rate, and arterial pressure), laboratory tests and requests for AE were used for the safety and tolerability analysis. AE was predefined as mild when it did not require the withdrawal of study medication, moderate when it required therapy discontinuation according to physicians' criteria and/or specific treatment of the AE, and serious when it led to or prolonged hospitalization, which could be fatal or nonfatal.
Blood samples were drawn from 8:00 to 8:30 AM. After an overnight fasting of 12 hours, and aliquots were obtained for laboratory determinations.
Liver enzymes (ALT, aspartate aminotransferase [AST], γ glutamyl transferase [GGT], alkaline phosphatase [ALP]), serum glucose, creatinine, bilirubin, TC, high density lipoprotein cholesterol (HDL-C), and TG were determined by enzymatic methods using reagent kits (Roche, Basel, Switzerland). LDL-C values were calculated using the Friedewald equation [29]. Insulin levels were determined using radioimmunoassay and the prothrombin time with the routine laboratory method.
The HOMA index was calculated as follows: HOMA = [fasting glucose (in mg/dL) / 18] × [fasting insulin (in µUI/mL) / 22.5]. Plasma TAS was assessed by using a reagent kit from Randox (NX2332, Randox, Antrim, UK) and values were reported in mmol/L.
Analyses were conducted in accordance with the intention to treat principle. The data of all randomized patients were analyzed. Sample size was calculated by assuming that the mean reduction from baseline of liver fat infiltration should be greater than 25% with respect to the change in the placebo recipients. A sample size of 25 subjects per group was estimated to be sufficient to detect such differences at a 5% level of significance with 80% power.
The data are presented as means ± SD. Continuous variables were analyzed using the Wilcoxon test for matched samples (within-group comparisons) and Mann-Whitney U test (between-group comparisons), being confirmed using tests for paired and independent samples, respectively. Categorical values were compared using Fisher's exact probability test and confirmed with the Ψ2 test. Two-side tests were used. A value of p < 0.05 was considered to indicate statistical significance.
Characteristics of the study patients
Of the 55 patients enrolled in this study, 50 were randomized to D-002 (25) or placebo (25). Five subjects were not included because they had no ultrasonographic evidence of fat infiltration. Six patients, three in each group, withdrew from the study; two of the placebo recipients withdrew due to AE.
Table 1 shows the baseline characteristics of the patients. Patients (27 females, 23 males; mean age, 55 years) in both groups were matched for all characteristics. Increased body mass (64.0%), elevated serum TC (78.0%), hypertension (50.0%), elevated serum TG (40.0%), smoking (28.0), and obesity (24.0%) were the most frequent (≥ 20%) findings in the personal history of the patients. Twenty-four of the 50 patients had concomitant hypertension, serum TG ≥ 1.7 mmol/L, HDL-C < 1.00 mmol/L, and fasting glucose ≥ 5.6 mmol/L.
Baseline characteristics of study patients
Concomitant medications, also comparable in both groups, were consistent with the personal history of the participants; antihypertensive, lipid-lowering, and oral hypoglycemic drugs were among the concomitant therapy taken most commonly by the study participants.
Efficacy analysis
No significant difference between the groups in dietary and treatment compliance was observed.
Effects on the primary efficacy outcome
Fig. 1 summarizes the ultrasonographic findings. At baseline, the stages of steatosis were comparable in both groups; no patient was classified as normal (score 0). In addition, 20, 24, and six patients had mild, moderate and severe steatosis, respectively, all degrees of liver fat infiltration being balanced in both groups. Seven (28.0%) D-002-patients and none of the placebo patients exhibited a normal liver echo pattern on ultrasonography at study completion (p < 0.01). Only 3/25 (12%) patients, all in the placebo group, demonstrated severe steatosis at the end of the study.
Degree of liver steatosis. ap < 0.01 Comparison with placebo (Fisher's exact probability test).
Effects on secondary efficacy outcomes
IR and other blood efficacy outcomes
D-002 treatment significantly reduced insulin levels and the HOMA index by 37% and 39.9%, respectively (p < 0.01 as compared to baseline and placebo) (Fig. 2); meanwhile, the TAS increased significantly, while the liver enzymes, serum glucose and lipid profile remained constant (p < 0.0001 as compared to baseline and placebo) (Table 2).
Secondary efficacy outcomes related to insulin resistance. (A) Insulin levels (µUI/mL). (B) Homeostatic Model Assessment index. ap < 0.01 comparison with baseline (Wilcoxon test for paired samples), bp < 0.01 comparison with placebo (Mann-Whitney U test).
Effects on other laboratory secondary outcomes
The proportion of D-002-treated patients who reported clinical improvement of some symptoms (12/25, 48.0%) was significantly greater than in the placebo group (2/25, 8.0%; p < 0.001), more placebo patients (22/25, 88.0%) than D-002-treated patients (13/25, 52.0%) reported no change in their symptoms (p < 0.05), and only one placebo patient declared that the symptoms had worsened.
D-002 (100 mg/day) given for 24 weeks was well tolerated by the patients. The treatment did not affect physical (bodyweight, pulse rate, arterial pressure) safety indicators, and did not modify significantly the remaining blood indicators (creatinine, bilirubin, prothrombin time; data not shown for simplicity). In addition, individual values remained within normal range. Only two placebo patients reported some degree of AE during the study (allergy and skin rash, respectively), which were causes of the two premature withdrawals.
Our data show that D-002 (100 mg/day) given for 24 weeks effectively reduced liver fat accumulation and IR in a group of patients with NAFLD. We observed a significant reduction in liver steatosis, HOMA index and insulin levels after 24 weeks of treatment, as well as a significant increase in plasma TAS, and symptom relief as compared to placebo patients.
Certain characteristics were overrepresented in the study subjects. Many were overweight (64.0%), had elevated serum TC (78.0%), hypertension (50.0%), elevated serum TG (40.0%), were smokers (28.0%) and were obese (24.0%) and the proportion of females surpassed that of males, consistent with the epidemiological characteristics reported for NAFLD [1,30-32]. Moreover, 24 (48.0%) patients had concomitant hypertension, serum TG ≥ 1.7 mmol/L; low HDL-C levels and fasting glucose ≥ 5.6 mmol/L, qualifying metabolic syndrome, a cluster of components including abdominal obesity, impaired glucose metabolism, dyslipidemia and arterial hypertension [33]. Nevertheless, since we did not measure waist circumference, a limitation of this study, we cannot confirm whether our patients were affected by this condition.
We did not use liver biopsy, the gold standard for the diagnosis and the only method able to differentiate simple NAFLD from NASH, and therefore we cannot rule out the possibility that this entity was present in some patients. Nevertheless, to avoid liver biopsy, one study proposed a NASH score based on cutoff values of noninvasive markers (BMI ≥ 47, ALT ≥ 32 IU/mL, AST ≥ 25 IU/mL, ALP ≥ 85 IU/mL, HOMA-IR ≥ 4, among others) in obese patients with liver steatosis [34,35]. In our study, only two patients with BMI ≥ 47 (1 placebo, 1 D-002-treated) had concomitant ALT, AST, ALP, and HOMA values greater than the proposed cutoff; these could indicate NASH.
The proportion of D-002-treated patients that achieved complete fatty liver regression assessed by ultrasonography (28%) in this study is promising, being slightly greater than that reported for 24 weeks of treatment with PUFA from seal oils (19.7%) [12]. The lack of a liver biopsy could hamper the relevance of our findings due to the subjective nature of the imaging methods used to diagnose NAFLD; i.e., ultrasound, computed tomography, and magnetic resonance imaging, all of which have high sensitivity and specificity for detecting steatosis, but are unable to differentiate NAFLD from NASH [36].
Nevertheless, despite its operator-dependence, abdominal ultrasound has been validated against histopathological specimens and other imaging methods in the diagnosis of liver steatosis [37]. It is thus suitable for the diagnosis and follow-up of patients with NAFLD because it is noninvasive, low-cost and widely available. In light of these facts and since this study was a pilot trial to assess the putative effects of D-002 on NAFLD, we selected ultrasound changes as a primary outcome because it is noninvasive, relatively simple and commonly used as the first approach to NAFLD diagnosis, meaning that the conditions of our study approximated those of routine clinical practice.
In addition, the randomized, double-blind, and placebo-controlled design of the study may reduce the impact of this subjective bias, since subjective mistakes should be equal between the two groups. Also, we included objective biochemical variables (IR markers, liver enzymes, TAS) as secondary efficacy outcomes, which contribute to the evaluation of the effects of D-002 on NAFLD patients.
Our data suggest that that D-002 (100 mg/day) effectively lowered IR in accordance with the significant decrease of the HOMA index (39.9%), an evidence-based surrogate measure of IR [38], and of the insulin (37%) levels after 24 weeks of treatment. In light of these facts, our results suggest the potential clinical relevance of the use of D-002 to improve IR in patients with NAFLD, an effect that could be explained by the action of triacontanol, the main component of D-002, which activates adenosine monophosphate (AMP)-kinase, likely leading to metabolic gene regulation and to AMP-mediated reduction of insulin secretion by pancreatic β-cells. This is similar to the effect of metformin, a well-known insulin-sensitizer [39].
Overall, the effect of D-002 on IR indicators (HOMA index, insulin levels) and TAS (an indicator of the antioxidant response) suggests its efficacy on the ultrasonographic improvement of liver fat accumulation [40]. In this study we evaluated the antioxidant effect of D-002 by assessing its effect on plasma TAS, a variable that allows estimation, as a whole, of the ability of the body's antioxidant systems to remove free radicals and ameliorate the damage they may cause [40]. This has been shown to be particularly reduced in obese children with NAFLD [41]. Therefore, the fact that D-002 increased TAS values indicates that it increased the antioxidant response in patients with NAFLD.
Currently, the cornerstone for NAFLD management is weight reduction, mainly a decrease in central obesity, and reversal of IR [8,9]. In our study, however, despite 23/24 placebo and 21/24 D-002-treated patients being advised to follow a specific diet, no body weight reduction was observed during the trial [8,9]. Thus, the improvement in liver fat accumulation, HOMA index and insulin levels observed in the D-002-treated group seems not to be strongly influenced by dietary intervention, but rather is attributable to D-002 treatment.
Transaminase levels did not change significantly during the treatment. Although this seems to disagree with our efficacy hypothesis, it could be related to the fact that most patients had normal or relatively low baseline transaminase levels, the most frequent being high GGT values (≤ 55 UI/L) (GGT, 41/50, 82%; ALT, 47/50, 94.0%; AST, 50/50, 100%).
In conclusion, treatment of NAFLD with D-002 seems to be effective and safe, and may ameliorate liver fat accumulation and clinical evolution of subjects, may reduce the HOMA index and insulin levels, and may increase the antioxidant response of the body, as assessed by plasma TAS. Nevertheless, further studies are needed to confirm the efficacy, safety, and tolerability of D-002 in NAFLD patients.
1. Oral administration of D-002 (100 mg/day) for 6 months may ameliorate liver fat accumulation and insulin resistance, meanwhile improve clinical evolution and antioxidant response in subjects with nonalcoholic fatty liver disease (NAFLD).
2. D-002 seems to be safe and well tolerated in subjects with NAFLD.
No potential conflict of interest relevant to this article is reported.
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37. Williams CD, Stengel J, Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011;140:124–131. 20858492.
38. Bonora E, Formentini G, Calcaterra F, et al. HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study. Diabetes Care 2002;25:1135–1141. 12087010.
39. Singh DK, Li L, Porter TD. Policosanol inhibits cholesterol synthesis in hepatoma cells by activation of AMP-kinase. J Pharmacol Exp Ther 2006;318:1020–1026. 16714400.
40. Messina D, Perez Elizalde R, Soto C, Uvilla A, Lopez Laur JD, Lopez Fontana C. High intake of lycopene together with low intake of red meat increases the total antioxidant status. Arch Latinoam Nutr 2012;62:15–22. 23477203.
41. Pirgon Ö, Huseyin B, Ferhat C, Huseyin K, Nuri DB. Association between insulin resistance and oxidative stress parameters in obese adolescents with non-alcoholic fatty liver disease. J Clin Res Pediatr Endocrinol 2013;5:33–39. 23367495.
Copyright © 2013 The Korean Association of Internal Medicine
(open-access, http://creativecommons.org/licenses/by-nc/3.0/) :
Values are presented as mean ± SD or number (%). All differences were nonsignificant (see Methods).
BMI, body mass index.
aValues > 5.00 mmol/L.
bValues > 2.2 mmol/L.
cConsumed by at least two patients.
Values are presented as mean ± SD.
TAS, total antioxidant status; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, γ glutamyl transferase; ALP, alkaline phosphatase; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol.
ap < 0.001 in comparison with baseline (Wilcoxon's test for paired samples).
bp < 0.05 in comparison with placebo (Mann-Whitney U test).
cp < 0.0001 in comparison with baseline (Wilcoxon's test for paired samples).
dp < 0.0001 in comparison with placebo (Mann-Whitney U test).


Noisy Diff, new fuel pump, battery, boot rubber, plugs and points and had oil change.
Interior in good condition no welding required underneath, exterior paintwork a bit faded.
Come and have a look !
Ford 100E Anglia 1956. Full history. Original.
1958 Ford Anglia de luxe 100E. Finished in Pompadour Blue with matching trim. Very sound, clean original condition. Drives really well. Great little car.


Tract was commissioned by Charter Hall and Watpac Constructions for urban design and landscape architectural services to 275 George Street, a keynote Brisbane CBD site.
Our work included close co-ordination with both Crone Partners and Cottee Parker Architects to create a high quality, functional series of connected urban plazas, cafe and bistro dining, corporate building doormats and "people spaces". The design was also responsive to the adjacent streetscape of 275 George Street, providing iconic street frontage for both retail and commercial opportunities.
The design further retains key axial vistas and visual guides through the plazas to the iconic Brisbane City Hall and central plaza node. With the majority of the ground floor dedicated to pedestrian activity, the inclusion of broad pedestrian breezeways and connections, featured art installations and high quality detail provide a safe, equitable and pedestrian responsive output, while being respectful of scale of the architectural elements and the general functionality of these spaces.
Key features of the design include the expansive use and combination of bluestone pavers and porphyry stone as both a decorative functional surface and wayfinding pattern within the plaza. In addition to the intuitive wayfinding promoted by the pavement and art placement, custom designed precast seating bowl planters further strengthen the intuitivity of the wayfinding arrangement by shorelining the plaza space and addressing the vertical building facade interface with the ground plane.


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Why did you become a dentist of all things?
I was a very goofy teenager becoming more and more conscious that my teeth arrived before the rest of me! Luckily I was at school in Bedford and a number of my classmates were the sons of dentists. Mr Kettler, who at the time was President of the British Orthodontic Society, had a very successful practice just outside the school gates (yes we were locked in), and had in no time fixed me up in headgear and wires not dissimilar to young Willy Wonker!
What was it like studying at Guys Hospital in London?
Tough. Fluoridation of the water supply was expected to reduce the number of dentists required and the Government closed several dental schools the year I applied. Competition was fierce for places but thank fully I got the grades!
It was amazing studying under the leaders of the profession.
Guys has always been Europe's most prestigious dental school Its research is rated 5 stars in every department. Cambridge and Oxford don't teach dentistry as dental schools have always been sited in centres of large populations – Guys serving The City, South London and the whole of South East England.
I spent a year with Professor Poswillo and Mr Bret Day working as House Surgeon in the Oral Surgery department. At 22years I was the possibly the youngest qualified dentist in the UK. I was a little homesick and tired of study so I returned home to Bedfordshire and completed a year of Vocational Training in a NHS practice in Biggleswade. I was shocked – too many patients, too little time, while the boss drove around in a new car cracking the whip ! Luckily I was offered a position in a private practice run by Robert Tutton in Royston near Cambridge. This was a brilliant move for me.
Robert was so thoughtful and cared so well for his patients. He gave me time to develop my skills and when I was ready helped me find the right practice of my own, knowing Aldeburgh to be the perfect place.
The Dental Practice sales agent was London based. He tried to convince me to buy a London practice and suggested there would be nothing to do in Aldeburgh during the winter. I thought great I can go skiing!. How wrong he was. I arrived in July 1997and by December the practice was bursting at the seams!
Who's had the biggest influence on your professional career to date ?
Apart from the afore mentioned definately my former associate Dr Colm O'Loglen.
He joined me in 2002 after we met on a dental implant course and stayed five years. Things somehow clicked and we are still close friends to this day sharing tips on an almost weekly basis! He left to takeover his father's practice in County Kerry, without doubt he's become one of Ireland's most able and respected practitioners.
I always had a soft spot for Framlingham. The castle, the great schools and the more relaxed rural atmosphere. The population is obviously much younger and vibrant. That's what happens when schools work well and are able to bring the very best out of young people.
We're continuing to develop a great family practice. I believe the practice has already become a very valued community asset.
What have been the highs ?
Happy, well cared for patients supported by enthusiastic staff who love dentistry.
Continued Government support that allows us to offer exceptional NHS dental care to children and young adults.
The fantastic support within the dental profession that I believe is totally committed to doing the best for the Nation's teeth. The BDA are a fantastic organisation and are now working with the Care Quality Commission (CQC) to ensure that dental treatment within the UK is probably the safest worldwide – well done folks!
It seems you sometimes have to take a step backwards before you move further forward.
Managing building projects whilst having to keep the practice running and looking after patients.
Great nurses stopping to have a family.
Finding good replacements for well liked associate dentists leaving to start their own dream practices.
Running a business alongside your professional responsibility to your patients – I truly wish we could do it all for free.
Trying to do quality dentistry on demanding mature patients within the current restrictive NHS dental contract – good dentistry needs time and investment.
Constantly updating my skills to ensure that we are able to offer my patients the very best and trusted treatment options.
The practice has made huge investment in the very latest digital low dose x ray technology.
We believe we are the only practice in Suffolk with a CBCT 3D scanner necessary for the safest, most predictable placement of dental implants. This allows us to create a 3 dimensional computer image of the patients jaws so we can calculate and place implants safely without damaging vital structures otherwise hidden from view.
Time spent relaxing with Cheryl, our young family and two crazy Jack Russells.
And of course regular trips to Bad Gastein Salzburg in the Austrian alps.
Where do you see the profession in 15 years time?
Its a great time to be involved in the dental profession.
Its even better being a patient.
Super anaesthetics, modern equipment with happy caring staff make a visit to the dentist so much better now than ever before.
Dentistry is literally on everyone's lips. Its seems every time you turn on the TV dentistry and its marvels are being talked about.
New techniques are giving people the smiles they dreamed of and making the daily life of dentists fascinating.
The dental industry is booming with Smile makeovers and complex procedures being carried out in quality private practices through out Britain and not just expensive fashionable London clinics.
The days of wearing loose dentures or having unsightly teeth are behind us.
Modern crowns, bridges, veneers, implants and whitening techniques are making treatment planning options remarkable.
Patients now have the choice to live with a great smile forever.
The profession is attracting the most talented youngsters of the next generation.
Its remarkable how many children of dentists go on to join their parents. Its also quite interesting that many regular medical practitioner's are now encouraging their own children to look into a dental career instead of medicine. In August we have the son of a long line of Bavarian doctors joining us for a weeks work experience all the way from Germany.
The future certainly looks very bright indeed.


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text:
Q: how to hide/show a React component depending on device browser? Looking to hide/show a component in a React/Nextjs/tailwind webapp depending on the device that the user is on (e.g. desktop vs tablet vs mobile) since there are certain keys on the keyboard available for desktop but not on table and mobile (e.g. the tab key). Don't want to do it by screen size since this is a device problem (no tab on keyboard) rather than a screen size problem
Initially I thought about getting device type (code referenced from another stackoverflow Q/A), but this seems to fail when the user is on a device such as an ipad and is using the Desktop version for that browser (e.g. Desktop safari and not mobile safari). Is there a better way to handle this such that it can properly check what device the user is on in order to be able to hide/show the react component?
const getDeviceType = () => {
  const ua = navigator.userAgent;
  if (/(tablet|ipad|playbook|silk)|(android(?!.*mobi))/i.test(ua)) {
    return "tablet";
  }
  if (
    /Mobile|iP(hone|od)|Android|BlackBerry|IEMobile|Kindle|Silk-Accelerated|(hpw|web)OS|Opera M(obi|ini)/.test(
      ua
    )
  ) {
    return "mobile";
  }
  return "desktop";
};

A: In JavaScript you can detect browser with JavaScript using window.navigator
Code example according to https://developer.mozilla.org/en-US/docs/Web/API/Window/navigator would be
var sBrowser, sUsrAg =
navigator.userAgent;

// The order matters here, and this may
 report false positives for unlisted
 browsers.

 if (sUsrAg.indexOf("Firefox") > -1) {
sBrowser = "Mozilla Firefox";
// "Mozilla/5.0 (X11; Ubuntu; Linux
x86_64; rv:61.0) Gecko/20100101
Firefox/61.0"
}

alert("You are using: " + sBrowser);

But for react there's another package you can use that is npm install react-device-detect
Code example would be
import { browserName, browserVersion }
from "react-device-detect"
console.log(`${browserName}
${browserVersion}`);

After detecting browser you just conditionally render whatever you want to show


text:
Guenther Funeral Home, Inc.
Send Flowers for Darwin
Darwin L. Mascho
Bolivar- Darwin L. Mascho, of 211 Reed Street, died Monday (November 30, 2020) at the Olean General Hospital.
Born February 22, 1947 in Wellsville, he was the son of the late, Junior and Arrilla Pangburn Mascho. He married the former Nancy Pitts on October 16, 1965, she predeceased him on January 1, 2012.
Darwin worked for over 40 years for Dresser Rand in Wellsville. He enjoyed bird watching, a good sunset, and driving around for hours. He also enjoyed blacksmithing and spending time with his dog, Ricco. He will be remembered for his Willie Nelson impressions.
Surviving are six children; Bradley (Angela Moore) Mascho of Bolivar, Todd (Cathie Geens) Mascho of Pavilion, Darla (Scott Murphy) Mascho of Bolivar, Stacie Ross of Bolivar, Darnell (Jackie) Mascho of Shinglehouse, PA, and Sheilah (Bob) Borden of Belfast; eleven grandchildren; sixteen great-grandchildren; and one brother, Rev. Ernest (Marjorie) Mascho of Norristown, PA.
In addition to his wife, he was predeceased by a son-in-law, Charlie Ross.
Friends will be received at the Guenther Funeral Home, Inc., 1303 E. State Street, Olean on Friday (December 4, 2020) from 11am-1pm, with funeral services to follow at 1pm. Burial will be in Maple Lawn Cemetery, Bolivar.
Memorials, if desired, may be made to the Alzheimer's Association, 6215 Sheridan Dr., #100 Buffalo, NY 14221.
Online condolences can be made at www.guentherfh.com.
To send flowers to the family or plant a tree in memory of Darwin L. Mascho, please visit our floral store.
1303 East State Street
Olean, NY 14760
© 2021 Guenther Funeral Home, Inc.. All Rights Reserved. | Terms of Use | Privacy Policy


Calories in olive oil compared to other oils and olives.
Olive Oil is considered one of the most healthy oils, but too much of a good thing will still make you gain weight. Simply stated, there are a lot of calories in olive oil. An average of 1 tablespoon a day when trying to lose weight should be enough. If you are getting fats and oils from other sources you will not need this much.
One thing you will notice about this chart is that there are little vitamins and minerals left after processing the oil. Why not eat olives and get some oil that way. The olives will have more nutrition. Olives have anti-inflammatory properties, they are full of anti-oxidants, and have even been found to increase bone density. Be careful though; I know that olives will put the weight on me.
The data above was taken from the USDA National Nutrient Database. It was not specific about what kind of olive oil, but in general extra virgin olive oil should have slightly more flavor and nutrition. Keep your olive oil fresh. It is best if it is less than a year old.


Why is housing so expensive in major West Coast and northeastern cities? Not just more than you might want to pay, but, often, prohibitively expensive with little sign of new supply in areas people want to live. Chris Elmendorf joins us to explain this problem and the limited effectiveness of two types of solutions, the Northeastern and West Coast models. Drawing on the intergovernmental approach of the Voting Rights Act, Chris argues that a strong state role in reviewing the regulatory activities of local governments, if done in the right way, could be the way forward. And it points to a dramatic rethinking of how land use law should be made and what problems it should try to solve.


text:
Home > Companies > Meesho
meesho.com
Meesho is on a Mission to Create 20M Entrepreneurs by 2020. Meesho is India's Largest Reseller Platform, poised to be the next big e-commerce distribution channel, where homepreneurs sell on WhatsApp, Facebook and Instagram. Meesho's network is 10,00,000+ strong, spread across 500+ towns. Meesho is a Y Combinator S16 startup and Series B funded by Sequoia India.
Riverside County Small Business Conference
Make Your Small Business More Accessible
PILLAR LAUNCHES ECONOMIC RECOVERY EFFORT FOR RAINIER VALLEY SMALL BUSINESSES
Pillar | February 11, 2022
Pillar launched an inaugural round of grantees and an open call for applications in Rainier Valley. In partnership with local community-based organizations, the initiative directs philanthropic dollars to independently owned businesses providing vital jobs, goods, and services. Pillar develops its grantmaking method by identifying and partnering with reputable local groups. Global Majority Consortium (GMC) co-led early community engagement and recipient selection in Rainier Valley...
INMUNE BIO, INC. AWARDED $2.9 MILLION NIH SMALL BUSINESS INNOVATION RESEARCH GRANT TO SUPPORT PHASE 2 STUDY OF XPRO1595
INmune Bio, Inc | September 16, 2020
INmune Bio, Inc. (NASDAQ: INMB) (the "Company"), a clinical-stage immunology company focused on developing treatments that harness the patient's innate immune system to fight disease, today announced it has received a $2.9 million Small Business Innovation Research (SBIR) grant from the National Institutes of Health (NIH), of which (subject to the terms of the grant), the Company will receive $739,739 this year, $1,210,682 next year with the balance to be received in 2022. The ...
BOLD PENGUIN AND AMTRUST EXPAND SMALL BUSINESS INSURANCE PARTNERSHIP
Bold Penguin | January 12, 2021
Bold Penguin, a quickly growing insurance innovation supplier, declares today a development of its association with top small business insurance supplier AmTrust. AmTrust joins a growing rundown of transporters on the stage that offer an inserted, completely computerized citing experience in laborers' remuneration inclusion for small businesses. AmTrust, an innovator in advanced development, who united with Bold Penguin in Q2 2020, has extended its in-application restricting c...
LENOVO PARTNERS WITH QUEEN LATIFAH FOR SMALL BUSINESS EVOLUTION
Lenovo | October 17, 2022
Lenovo announced that Grammy and Emmy Award-winning and Oscar nominated, actress, producer, recording artist, label president and entrepreneur, Queen Latifah will be the face and partner for this year's iteration of the global technology powerhouse's Evolve Small initiative. Built to champion and promote small businesses, Evolve Small provides financial aid, technological resources, community support, and business mentorship to small businesses across North America. With the help of ...
Analytix Solutions - Your Trustworthy Small Business Outsourcing Partner
FINANCE , SMALL BUSINESS ADVICE
L09 business financing
The business metaverse with real-life applications
The Best Types of Advertising for Small Business


Town have signed Zeki Fryers on loan from Crystal Palace until the end of the season, subject to paperwork.
The former Manchester United and Tottenham defender moves to Portman Road and could make his debut against Bournemouth on Good Friday, with Tyrone Mings ruled out through suspension.
Zeki has Championship experience after spending time on loan at Rotherham United earlier this campaign, making 10 appearances for the Millers.
The 22 year-old began his career with hometown-club Manchester United but left after his contract ran down and joined Belgium side Standard Liege.
The left-back then quickly joined Tottenham Hotspur following his seven game stay in Belgium and went on to feature a further seven times at White Hart Lane.
Zeki then moved to Crystal Palace in August for an undisclosed fee but has been unable to force his way into the first-team picture and has been allowed to join Town on loan.


The Peach Belt Conference (PBC) released its Women's Basketball All-Academic Team Wednesday, with Georgia College putting four student-athletes on the list.
Matthew Griffin, a senior management major, was one of eight finalists in the TYE University competition.
The College of Health Sciences honored its 2019 students for their outstanding academic accomplishments on April 5th.


In response to the devastating typhoon that struck the whole island of Mindanao in the southern Philippines on 22 December 2017, AMDA will be sending a team of relief personnel to Cagayan de Oro in the Province of Misamis Oriental. The torrential rain has caused the flooding of Cagayan River in the region, affecting the city located in the downstream area.
AMDA team comprising one nurse and two coordinators had already been working in the Philippines for the earlier typhoon disaster on the island of Biliran. Now that the extent of the damage brought about by the newly emerged typhoon is dire, the team will be heading to Cagayan de Oro accordingly. In the evening of the 25th, the team had a briefing with our local partner, to discuss further relief effort.
According to DSWD (Department of Social Welfare and Development), the affected population across 998 districts is 541,005 people (115,568 households) with which 182,377 people (37,424 households) have fled homes to seek shelter on higher grounds (as of 25 December).


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Our team is glad to present the redesigned WheelchairAssistance website! Wheelchairs let people with disabilities to travel relatively easily and to live a self-determined and active life. Everyone can find many diversetypes of wheelchairs to meet individual users' requirements, such as manual wheelchairs, electric wheelchairs, power wheelchairs. It is generally a chair set on wheels, which can be propelled either by hands o relectrically. Wheelchairs became a real godsend for the Disabled. They are invented to provide mobility to the persons for whom walking is impossible or hard. Lots of inventions have been made in the wheelchair area to make the life of people with disabilities more convenient. Keep in mind that Disabled just means differently-abled. These persons are free to travel wherever they want with the maintenance of wheelchairs. If you search for three wheeled mobility electrical scooter lightweight, than you are in the right place.
People use mobility scooters for lots of years. A mobility scooter is a device that can be utilized by those who have mobility problems to move around independently and without outside help. normal things such as going to the pharmacy or supermarket can be hard to mobility challenged people. Taking a look at the wide diversity of mobility scooters that are being offered on the market today, you can make no doubt that you will find the one suitable to your requirements. For example, some devices are made to transport you over diverse areas, at relatively high speeds while others can make steep turns allowing you to maneuver indoors. Mobility scooters guarantee a safe and reliable method for people with limited mobility. ofttimes individuals who can walk but experience some disadvantages, choose to utilize a mobility scooter in place of a wheelchair. There are many models, brands, sizes of mobility scooters that are being suggested on the market. an electric mobility scooter is a remarkable device that helps individuals with limited mobility with traveling problems. It opens doors and expands the boundaries of the world again. It is a wonderful way to guarantee the individual's mobility without any dependency on someone.


I would like to inquire about the property at 4074 Northlake Boulevard Palm Beach Gardens, FL 33410.
The Commercial,Free Standing property located at 4074 Northlake Boulevard, Palm Beach Gardens, FL 33410 is currently for lease. 4074 Northlake Boulevard, Palm Beach Gardens is listed for $4,300,000. This property has approximately 10,027 Sq. Ft. , and Lot Size of approximately 1.37 Acres. If the property located at 4074 Northlake Boulevard, Palm Beach Gardens, FL isn't what you're looking for, search Florida commercial real estate to see other properties for sale or lease in Palm Beach Gardens.