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North Shore Rhythmics in France and Russia!
Go, USA! Over the past few weeks, North Shore Rhythmics U.S. national team members represented the United States in competitions in France and in Russia. On March 25-29, members of the U.S. national senior group--Megan Frohlich, Michelle Przybylo, Sofya Roytburg, Sydney Sachs, and Marlee Shape--competed in the Rhythmic Gymnastics Grand Prix in Thiais, France. And then on April 3, they qualified for the finals in the Rhythmic Gymnastics World Cup in St. Petersburg, Russia. JoAnna Arnold, Jazzy Kerber, and Shelby Kisiel competed in the individual competition in St. Petersburg.
Int'l Competitions
National Qualifiers
NSR Life
Pan Am Games
Regional Meets
State & Invitational Meets


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Home Precision Medicine Research CRISPR Technology Used to Repair Duchenne Muscular Dystrophy Gene
CRISPR Technology Used to Repair Duchenne Muscular Dystrophy Gene
Source: anyaivanova/Getty Images
Scientists have developed a nonviral approach to delivering the CRISPR/Cas9 gene-editing system to cells that when tested in the mdx mouse model of Duchenne muscular dystrophy (DMD) repaired the faulty DMD gene, leading to improved strength and agility and reduced fibrosis. The platform, called CRISPR-Gold, uses gold nanoparticles to encapsulate all the elements needed for CRISPR/Cas9 gene editing and deliver them directly to cells. "CRISPR-Gold and, more broadly, CRISPR-nanoparticles open a new way for safer, accurately controlled delivery of gene-editing tools," claims Irina Conboy, Ph.D., a bioengineering professor at the University of California, Berkeley (UC Berkeley), who co-led the CRISPR-Gold research alongside UC Berkeley's professor Niren Murthy, Ph.D., and collaborators in the U.S. and Japan. "Ultimately, these techniques could be developed into a new medicine for Duchenne muscular dystrophy and a number of other genetic diseases."
The authors report their research in Nature Biomedical Engineering, in a paper entitled "Nanoparticle Delivery of Cas9 Ribonucleoprotein and Donor DNA In Vivo Induces Homology-Directed DNA Repair." Prof. Murthy, together with UC Berkeley co-authors Kunwoo Lee, Ph.D., and Hyo Min Park, Ph.D., have set up a company, GenEdit, to develop the CRISPR-Gold technology for use in humans.
There are two basic categories of gene editing to which CRISPR/Cas9 gene editing could potentially be applied in a therapeutic setting, the authors explain. The first, based on nonhomologous end joining, aims to permanently silence disease-causing genes by inducing indel mutations. The second, based on homology-directed repair (HDR), aims to correct disease-causing gene mutations back to their wild-type sequences.
Although the use of CRISPR/Cas9 to correct mutations via HDR has the potential to "revolutionize" the treatment of genetic diseases, in practice the approach is challenging because HDR-based therapeutics would need to simultaneously deliver the Cas9 protein, a guide RNA that directs Cas9 to the correct gene, and donor RNA, they note. The most advanced of the current potential delivery systems based on adeno-associated viruses (AAVs) can't be used universally because a large proportion of the human population has pre-existing immunity toward AAVs, while AAV-based Cas9 delivery also has the potential to cause significant off-target genomic damage. There are similarly challenges associated with the direct delivery of Cas9 ribonucleoprotein (Cas9-RNP) using vehicles such as lipofectamine and polyethylenimine.
In contrast, the CRISPR-Gold delivery system comprises gold nanoparticles (GNPs) conjugated with DNA, which are complexed with the donor DNA, Cas9-RNP, and an endosomal disruptive polymer, poly[N-(N-(2-aminoethyl)-2-aminoethyl] aspartamide [PAsp(DET)]. When injected locally, the nanoparticles are recognized by cells and are readily internalized via endocytosis. The PAsp(DET) polymer then triggers endosomal disruption, so that the CRISPR-Gold nanoparticles are discharged into the cytoplasm, where the Cas9-RNP and donor DNA are released from the nanoparticle gold core.
The UC Berkeley-led team has now shown that the CRISPR-Gold system can be used to deliver all the components required for CRISPR/Cas9-mediated HDR directly to a wide variety of therapeutically relevant cell types, including human embryonic stem cells, human induced pluripotent stem cells, and bone-marrow derived dendritic cells, as well as myoblasts from the mdx mouse model. Using the CRISPR-Gold platform, HDR efficiency was typically 3% to 4%, and there was minimal off-target DNA damage. "CRISPR-Gold is the first example of a delivery vehicle that can deliver all of the CRISPR components needed to correct gene mutations, without the use of viruses," Dr. Murthy states.
Having demonstrated the technology in cells, the team then turned to the mdx mouse model of DMD as a therapeutic test case for CRISPR-Gold. In humans, the muscle-wasting disease is caused by mutations in the dystrophin gene, and about 30% of patients have single base mutations or small deletions that could feasibly be corrected using HDR-based strategies. However, the only current gene-editing strategy for treating the disease is based on nonhomologous end-joining–induced exon skipping, which generates a shortened form of dystrophin that is only partially effective, the UC Berkeley team notes.
In contrast, a single intramuscular injection of CRISPR-Gold in mdx mice led to 5.4% of the mutated dystrophin gene being corrected back to wild type. This rate of correction was 18 times better than when the Cas9-RNP and donor DNA were injected on their own. Muscle tissue injected with CRISPR-Gold also demonstrated robust dystrophin protein expression. And when compared with control animals, the CRISPR-Gold-treated mice showed a two-fold improvement in hanging time in a four-limb hanging test.
Encouragingly, when the team then carried out deep sequencing analysis, they found that the degree of off-target DNA damage caused by CRISPR-Gold was no different from the levels of sequencing error (0.005–0.02%) found in a typical cell that hadn't been exposed to CRISPR-Gold. "These results demonstrate that CRISPR-Gold can induce HDR in muscle tissue with minimal off-target genomic damage, effectively edit the dystrophin mutation in mdx mice to the wild-type sequence, and improve animals' strength under clinically relevant conditions," the team claims.
To test for potential immunogenicity, the researchers also measured blood cytokine levels in treated animals, 24 hours and two weeks after CRISPR-Gold injection. They found no signs of inflammatory cytokine upregulation, or weight loss, even after multiple injections, "suggesting that CRISPR–Gold can be used multiple times safely and that it has a high therapeutic window for gene editing in muscle tissue."
"CRISPR–Gold offers a new therapeutic strategy for treating DMD caused by point mutations and small deletions," they write in their published paper. "More broadly, our results demonstrate that non-viral delivery vehicles can generate HDR in vivo and have great potential for treating genetic diseases."
In parallel with the establishment of GenEdit, ongoing work at the UC Berkeley laboratories of Drs. Murthy and Conboy is focused on developing the next generation of particles that could deliver CRISPR-Gold into tissues from the bloodstream and preferentially target adult stem cells
Accumulation of Inherited Common Genetic Variants Implicated in Migraines
Angle Enrolls First Patient in Trial of Parsortix CTC Liquid Biopsy
Novel Cell-Free DNA Blood Test Effectively Detects Down Syndrome

redpajama_set_name: RedPajamaCommonCrawl


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Papua New Guinea competed in the 2014 Commonwealth Games in Glasgow, Scotland from 23 July to 3 August 2014. Papua New Guinea participated in the Commonwealth Games for the thirteenth time. Over its previous participations, its athletes won a total of nine medals, of which two gold. Swimmer Ryan Pini, Papua New Guinea's most successful competitor with a gold in 2006 and a silver in 2010, is not competing in Glasgow, but is present as "assistant coach and mentor" for PNG's swim team.

Medalists

Athletics

Men
Track & road events

Women
Track & road events

Judo

Men

Rugby sevens

Papua New Guinea has qualified a rugby sevens team.

Pool C

Swimming

Men

Women

Triathlon

Weightlifting

Men

Women

 Powerlifting

References

Nations at the 2014 Commonwealth Games
Papua New Guinea at the Commonwealth Games
2014 in Papua New Guinean sport

redpajama_set_name: RedPajamaWikipedia


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Le vindaye est un plat de la cuisine mauricienne préparé à partir de poisson, le plus souvent du thon ou de l'espadon.

Préparation

La préparation consiste en la friture de poisson dans du vinaigre avec de la moutarde, de l'ail et diverses épices.

Consommation

Il peut être consommé froid en « gajak » c'est-à-dire avec du pain, en sandwich, notamment au cours de pique-nique. Il peut également être consommé chaud avec un accompagnement.

Références

Cuisine mauricienne


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VNSNY to take Covid-19 referrals from hospitals
Mother Cabrini foundation pledges $50M in relief aid
State portal will make volunteer doctors, nurses available to hospitals
NYU Langone handling nearly 5,000 daily video visits weeks after launch
Jennifer Henderson
Jonathan LaMantia
The Visiting Nurse Service of New York today will begin accepting Covid-19 referrals from local hospitals. The goal is to offset some of the burden, but it won't come without challenges.
"We want to do everything possible to alleviate the strain on the New York metro area's hospital system," said Michael Bernstein, executive vice president and chief administrative officer at VNSNY.
For Covid-19 patients who are stable enough to be discharged after a hospital stay, VNSNY will provide home care for their flulike symptoms and underlying medical conditions, such as diabetes or chronic obstructive pulmonary disease. The intent is to free up hospital beds for patients who are in serious condition and need ventilators.
"We are working rapidly to deploy more telehealth and remote patient visits," Bernstein said. Using virtual services for some routine visits enables more staff to go into the homes of Covid-19 patients.
The organization spent about $200,000—an unbudgeted expense—to secure additional tablets and equipment for remote patient monitoring, he said. And it's spending hundreds of thousands of dollars more to buy personal protective equipment.
On top of masks, gowns and gloves, equipment needed to safely care for Covid-19 patients in their homes includes disposable thermometers, stethoscopes and blood pressure cuffs.
VNSNY will keep the equipment at patients' homes. Kits—which will need to be replenished after five visits—also include 13-gallon trash bags for safely removing and disposing materials.
Home care visits for Covid-19 patients are being scheduled at the end of the day as an extra precaution.
Aside from home care, VNSNY has begun providing hospice care for patients with the virus.
To help home care agencies better ease the burden hospitals are facing, Bernstein called for the federal government—with the support of state government—to ensure that agencies are using telemedicine to safely take care of other patients while diverting resources for those with the virus.
"It's critically important for the entire home care industry to be able to provide telehealth services and get fairly reimbursed for it," he said. The Centers for Medicare and Medicaid Services has not yet ruled that remote patient monitoring is a billable way to provide service.
"Home care is the infantry: We go into the field; we go into people's homes," Bernstein said. "As long as we are equipped with the right personal protective equipment, that's what we can do. And that can help alleviate the strain on the health care system." —Jennifer Henderson
The Mother Cabrini Health Foundation said Tuesday that it will distribute $50 million to support nonprofits addressing the health-related needs of New Yorkers as a direct result of Covid-19.
The coronavirus emergency support grants will go to community-based funds, health care providers and Catholic Charities affiliates, among other organizations. The goal is to address the health and economic impact of Covid-19 on the elderly and individuals with underlying health conditions. That includes helping providers deliver care during the pandemic, offering mental health services and ameliorating food insecurity, Msgr. Gregory Mustaciuolo, CEO of the foundation, said in a statement. He added that the foundation will continue to adjust its response as needs arise.
The grants will be distributed by invitation to expedite the process.
Earlier this month the foundation announced its first grants, valued at $150 million. The round followed the formation of the $3.2 billion foundation in 2018 through proceeds of the Catholic church's sale of nonprofit health plan Fidelis Care to publicly-traded Centene for nearly $3.8 billion.
The foundation is among the largest in the country and focuses exclusively on New York. —J.H.
The state has set up a portal to enable hospitals to access the 78,000 volunteer nurses and physicians who have signed up to help with the response to Covid-19.
The state has vetted the medical reserve corps to weed out individuals with licensure or disciplinary issues.
The Cuomo administration has 175 people doing background checks on the volunteers, and hospitals would be expected to do their own vetting as well, said James Malatras, a special aide to Gov. Andrew Cuomo who has been working with the administration on the Covid-19 response. He said he expects the first of these workers to arrive at hospitals Thursday.
"Hospitals we're working with will also do their own checks to make sure the person's up to it," Malatras said. "They may not be up to one job, but they may be up to another."
The portal is broken down by region, and the state is making in-state volunteers available first before moving to clinicians from other states, Malatras said.
"What we're trying to do is prioritize the availability of the portal to the hospitals that need it the most right now, that need some extra help in the field, but we're working very closely with the entire system," Malatras said.
Cuomo said the state is leading a central coordinating team to manage the activities of public and private hospitals along with the Greater New York Hospital Association and the Healthcare Association of New York State. Those tasks will include configuring additional hospital beds, distributing supplies and shifting staff around the state. The governor said the goal will be to alleviate the stress on certain underresourced facilities, such as Elmhurst Hospital Center.
One step has been to add temporary hospitals that can treat lower-acuity patients. New York City opened a new 350-bed medical facility Tuesday at the UBillie Jean King National Tennis Center in Flushing Meadows-Corona Park to provide such assistance in Queens.
The governor said there were nearly 76,000 confirmed cases of Covid-19 in the state, including about 9,300 that were newly identified as of Tuesday. New York City had about 43,000 cases.
There were about 11,000 people who were hospitalized statewide as of Tuesday, with 2,700 in the ICU. Nearly 5,000 people have recovered and been discharged since the outbreak started. —Jonathan LaMantia
NYU Langone Health says it's now doing nearly 5,000 video visits a day since it first expanded its telemedicine programs in mid-March.
The health system already had offered virtual urgent care for immediate medical needs, but its latest offering gives it an option for more routine office visits.
Since launching the video visits on March 19, NYU Langone has completed almost 21,000 sessions.
About 1,300 of NYU Langone's 3,000 physicians are now using the video-visit platform, which is powered by technology from Epic, giving doctors access to patients' medical records. It was under development before tens of thousands of New Yorkers began getting sick with Covid-19.
Providers have looked for telemedicine solutions to continue seeing patients during the outbreak as they try to prevent transmission of the virus among patients and employees.
The service is open to the approximately 3 million people with active medical records at NYU Langone. Patients who don't have a relationship with NYU Langone could use the virtual urgent care option.
"Now that the visits in the office have dropped off so substantially, we're discouraging people from coming to the office unless they really need a doctor," said Andrew Rubin, NYU Langone's senior vice president for clinical affairs and ambulatory care. "Even then it's for non-Covid [patients]. If you need an office visit and you have Covid-19 symptoms, we won't let you into the office. We'll tell you to stay home and isolate and go to the emergency room if you're in distress."
Rubin said NYU Langone is still waiting to see how it will be paid by government and private insurers for the video visits after it began billing about two weeks ago, but it is optimistic given statements by Medicare and commercial payers.
"We're not doing this for money. We're doing this to take care of our patients," Rubin said. "The fact that we can generate some revenue to recoup some of the money that we're not getting because we can't see the patients in the office certainly helps us keep the system running. But overall Covid-19 is going to have enormous financial consequences." —J.L.
BUDGET: The state Assembly adjourned shortly after midnight without finalizing a budget for fiscal 2021, which starts today. There was little clarity regarding the state's Medicaid redesign plan and whether Gov. Andrew Cuomo and the Legislature would reduce spending on Medicaid by $2.5 billion as New York's health industry battles Covid-19. Lawmakers expect to finalize a budget of around $173 billion, which would be $2 billion less than the previous year, and more than $5 billion less than was planned just a few months ago, Newsday reported. The final agreement won't include the legalization of adult use of marijuana.
UPSTATE HOSPITALS: Hospitals in western New York are unsure how they will be able to accept patients from downstate New York at the direction of the state Health Department as they prepare to respond to larger numbers of patients in their own communities, The Buffalo News reported.
NY RESIDENCIES: St. George's University said that more than one in four of its students that recently secured residencies will begin their careers in New York on the front lines of the coronavirus outbreak and a strained health care system. "International medical graduates will play a crucial role in meeting that demand," said Dr. Richard Liebowitz, the Vice Chancellor of St. George's University, in a statement provided to Crain's. "These doctors already compose nearly 40 percent of New York's physician workforce. They work in a number of different specialties, including emergency medicine, internal medicine, and more."
REPRODUCTIVE RIGHTS: New York Attorney General Letitia James on Tuesday co-led a coalition of seven attorneys general in asking the federal courts to immediately rule on a lawsuit filed against the Trump administration for making it more difficult for women to access abortion services under the Affordable Care Act. "As states across the nation take unlawful actions and use the coronavirus as an excuse to deny women their constitutional right to an abortion, it's more important than ever that the federal government stops its attack on women's reproductive rights," James said in a statement.
HSS commits to expansions, digital health in 2021
To send a letter to the editor, please email a message to [email protected]
Community organizations' sway in overcoming vaccine hesitancy lower than thought: poll
Medscape survey: Female physician burnout rate up during pandemic


Reflection: Kevin on his last day as a League player in "the best job in the world".
You nearly retired last year, but stopped. Why?
Yes, my mind was made up to finish at the end of last season. I keep telling Woking manager Garry Hill he could sell ice to the Eskimos and he changed my mind.
To stop playing football will leave a huge hole in my life as I love the game so much. Knowing your future and doing something you enjoy to replace the void left is important. I've seen so many ex-professionals who have really struggled with the transition and I do not intend to follow this trend. I decided to announce it as did not want anyone trying to change my mind.
I injured ligaments in my knee last year, resulting in the first operation of my career and this really affected me. I've been nowhere near my individual level this season despite my contribution to the team performing well. You have to know when the time has come to say thanks and good night.
You played in the Conference League in two different eras – how has it changed and are both as enjoyable?
It has changed because as a fresh-faced teenager playing for the Woking first team was a big deal and I was trying to change my life through football. Returning has been great as it's a kind of fairytale. I feel I have completed a full circle to come back and play for the club that gave me my chance.
It has been sad to think I am finishing at this point but I'm over the moon I am doing it here. Nothing has changed in terms of the league, a few different faces but the same amazing loyal fans at our club and in the league.
What do you think you will miss most when you finish?
Everything. It's a fantastic job, representing a club and having the support of thousands of people who would want to be in your shoes. You try to make them enjoy their match experience. It's the best job in the world.
Do you have any thoughts of staying in the game through coaching or, even, management?
Yes, coaching has been my third love behind my family and playing. I have been working at a fantastic club in Fulham for the past six years alongside some of the county's top youth developers in football. I have and will continue to travel the world in various sports to continue my own personal development and most importantly the players I work with.
I have attained my badges, and passed my degree with 1st class honours but essentially it is all about learning how to teach and develop the style of young players using the skills I have amassed.
If, and when, I decide to go into management I have no doubt I will be ready and have the rounded skill set. I need to be successful. Perhaps not enough ex-players prep for the future life. Some may not need to, and their name may mean them being given the opportunity without really deserving or when they are not ready. It's a different field to playing. I work six days a week, not like the life of a pro footballer. I am in the real world now.
You have done much to encourage sport in Seychelles. What has been the response?
I was born in Seychelles with a population of around 100,000 and I became the first person born on the islands to ever play in the Premier League. This comes with quite a responsibility as I've found that I became a role model to many youngsters.
Having been there on numerous occasions, it struck me that there was a real hotbed of talent in the country. All that was needed was some help with structure and giving the children hope that their aspirations could be achieved.
I used to travel back with equipment and kit donations for the football clubs and local schools and I put on a few coaching sessions.
I aim to do more as I will have more time to help. Through the help of the Professional Football Association, we set up The Kevin Betsy Foundation and have been charity registered for the past three years. We aim to be a positive influence on local communities and the country.
What was the biggest highlight of your career?
My professional debut at Anfield when Fulham played Liverpool.
What is the biggest regret?
I had a disagreement with a manager over selection. The manager was new into the job. I was top goal scorer and loving my football and playing well. He had just signed a new player in my position and he wanted to put me on the bench for a game. I expressed my feelings like my little boy would tantrum. I was bigger than my boots, quite literally, In the end the manager always wins and he managed to get me out of the club after a few months not playing. I was among the top earners so this probably added to his decision. I had to rebuild my career. In hindsight I should have just shut my mouth and shown no emotion to his decision. I have met the manager in question very recently and we are on good terms now. There are no hard feelings – life is too short. To be honest to this day, I still struggle not to show my emotions when it comes to football. I'm still growing my personality. But at least it shows passion.
What would be your advice to any youngster wanting to progress in football?
Sacrifice is essential. Work harder than the next guy and dreams can be achieved. Lastly, be prepared for bad times and disappointment, for it's dealing with these moments that will shape how far you can go.


The Cu Chi Tunnels are definitely worth the day trip out of Saigon. Vietnamese are proud of their resolve in their prolonged history of struggle against invading armies, and the story of the people of Cu Chi is indicative of that spirit. Just 65km (40 miles) northwest of Saigon, the Cu Chi area lies at the end of the Ho Chi Minh Trail and was the base from which Ho Chi Minh guerillas used to attack Saigon. As a result, the whole area became a "free-fire zone" and was carpet-bombed in one of many American "scorched-earth" policies. But the residents of Cu Chi took their war underground, literally, developing a network of tunnels that, at its height, stretched as far as Cambodia and included meeting rooms, kitchens, and triage areas -- an effective network for waging guerilla warfare on nearby U.S. troops. The U.S. Army's 25th Infantry Division was just next door, and there are detailed maps denoting land that was either U.S. held, Vietminh held, or in dispute.
Visitors first watch a war-era propaganda film that's so over-the-top it's fun. The sight supports a small museum of photos and artifacts, as well as an extensive outdoor exhibit of guerilla snares and reconstructions of the original tunnels and bunkers. Wear your "play clothes" if you choose to get down in the temples; the experience is dirty and claustrophobic. There is also a shooting range where, for $1 per bullet, you can try your hand at firing anything from a shotgun to an AK-47. At the end of the tour, visit the dining hall and try the steamed tapioca that was a Cu Chi staple. Souvenir hawkers abound. A half-day trip can be arranged with any tour company in Saigon, often including a visit to the Cao Dai Temple .


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Most new top diplomats are women
For the first time ever, Norway's foreign ministry has named more women than men to head the country's embassies and general consulates around the world. All the chiefs of Norway's foreign missions are assembled in Oslo this week for the ministry's annual gathering of the diplomatic troops.
Foreign Minister Espen Barth Eide of the Labour Party and the minister in charge of foreign aid, Heikki Holmås of the Socialist Left party (SV), are so proud of all their top women diplomats that they invited them all to lunch on Monday, reported newspaper Dagsavisen.
Boosting equality
"Both Espen and I have made a conscious effort to boost equality and make it easier for women to take their husbands and families abroad in such jobs," Holmås told Dagsavisen. Men have done that for years, with their wives and families dutifully following them to overseas postings, but it's been harder for women to get the same sort of spousal and family support.
"It's critical that everyone, also the spouses, thrive when they're stationed abroad," said Heidi Olufsen, a mother of four who has been named Norway's general consul in St Petersburg. Her children are now older and have their own broad international networks after earlier stints abroad, she said. Olufsen's lawyer husband will now commute between Oslo and St Petersburg.
Hege Hertzberg, who will become Norway's ambassador in Ghana, told Dagsavisen that she insisted her husband accept her job and join her abroad before they married. She admitted that some diplomat husbands have a hard time defining their role, and that there's more acceptance in Norway than in many other countries that men can mind the homefront.
Important for Norway's egalitarian image
Norway's efforts to champion equality at home make it important for the country to have so many women ambassadors and general consuls abroad, according to Holmås and Eide.
"Today, 55 percent of the ministry's underdirectors are women and 45 percent of the divisional directors are women," Eide told Dagsavisen. "That means we have qualified women who can apply for the top jobs." He still faces challenges, though, in getting women to apply for ambassador and general consulate posts.
"The formal glass ceiling in diplomacy has shattered," Eide said. "But men and women still think differently, and more men apply for these jobs than women." Hertzberg noted that "we don't want to impose quotas on ambassador or consulate posts, "but women can gladly be encouraged to apply."
The ranks of women ambassadors have also increased in other countries, not just Norway, "but often these jobs are tied to the women coming from the upper classes," said Sissel Breie, who's about to take over as Norway's ambassador in Jordan. Breie, who formerly was Norway's ambassador in Argentina, said that it was her driver there who had the biggest problem accepting her as the boss.


Dr. Michelle Seelman is a psychiatrist who specializes in the mental health needs of children, adolescents and young adults. She also has a special focus on women's mental health. She is board certified in child, adolescent, and adult psychiatry.
Dr. Seelman's practice focuses on the treatment of mood and anxiety disorders, behavior problems, school difficulties and family disruption. She works collaboratively with individuals, families and other mental health professionals to design a comprehensive treatment plan that suits the needs of each individual and family.
Learn more about our practice and how a child & adolescent psychiatrist can help you and your family.
Call the office for more information or send an online inquiry.


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With over 25,000 EDI Implementations, B2BGateway has seen a lot of different business requirements and has developed solutions for them. Our experienced project managers will identify solutions to make your EDI hassle free.
As the global EDI industry leader, B2BGateway has over 25,000 integrations with retailers, manufacturers and eCommerce businesses.
Outsourced EDI Testing & Validation is where a Trading Partner / Retailer outsources their EDI testing and compliance requirements to B2BGateway.
B2BGateway helps the Trading Partner/Retailer to onboard new suppliers by providing a custom built testing and validation portal for your suppliers, complete with your company logo and color scheme.
Suppliers will be able to quickly and easily complete testing and validation for each EDI document against the document specifications you have supplied in a timely and efficient manner and you will be able to free up staff resources and reduce costs.


Every person, and thus every couple, is unique and has different ideas, visions and expectations of the perfect series of images. Whatever you're hoping to get, we'll find out in a personal chat beforehand. I love hearing about your ideas and try to realise your wishes as good as I can.
You've been waiting for so long, and suddenly the day you've been highly anticipating is finally here - probably the most important day of your lives, your wedding day. I'll accompany you for at least 8 hours, and make sure to capture all the right moments, starting from you getting dressed (and nervous), exchanging rings, vows, and kisses, until you start dancing your shoes off.
Many couples love the idea of a creative couple-shooting before or after the wedding, the so called "Engagement- & After-Wedding-Sessions". Feel free to be as creative as you like, wether you prefer to shoot in the forest, in a city or by the beach, in dress and suit, or top and t-shirt, you have the power to decide. Hopefully we'll create many beautiful portraits for eternity. Of course we can also take individual portraits, the so called "Bridal Portraits".
Beautiful chaos rather than destruction - during this unique photoshoot we will draw attention to the dress (or the suit) and do something crazy with it, whether that means throwing paint on it or going for a swim or... the options are endless and creativity limitless. The thought behind it is that the bride won't wear the dress ever again, so why not do something original with it? It's all about finding alternative motifs - and most importantly: to simply have fun.
For prices and more detailed information about my services, please get in touch and I'll send you all further information. I'm looking forward to hear from you!
A wedding by the beach? Over the blue rooftops in Santorini? At a lake, in the mountains? There are so many wonderful destinations for a wedding. I love travelling, and am constantly inspired by all the places I get so see and the people I meet. Even though I'm based in Berlin, I'd be happy to accompany you to wherever you decide to say YES to each other.


Not any more. The cost of forming an offshore company varies depending on the jurisdiction you choose to incorporate. Seychelles, Belize and Dominica have among the best prices such as US $1,100 or US $1,350 to incorporate depending on whether or not you wish to use our nominee director services. After the first year and every year thereafter, there is a small annual maintenance fee which includes annual government fees and registered office and agent fees. In Seychelles, Belize and Dominica annual fees (all inclusive) are US $400 or US $650 depending on if you are using our nominee director services. US Limited Liability Companies (LLC's) from Delaware and Oregon are even less expensive, while BVI and Gibraltar are a little more expensive. The whole package may vary in different jurisdictions. Tax Wizards will give you one package price that will include everything you need to secure your ZERO TAX set up. You can check all prices by registering for free here .


text:
World|
Blocked out: httpshare
Internet providers ordered to block file sharing website
Operators attempt to circumvent move; IFPI: We will take action against international sites as well
Ehud Kenan|Published: 03.06.08 , 08:54
The Haifa District Court two weeks ago ordered the three largest internet service providers in Israel to block access to the Israeli file-sharing site httpshare, this following a petition levied by the 12 largest record companies in Israel.
Court: Illicit site ought to be blocked
The controversial site, httpshare, doesn't contain any actual movies or music files for surfers to download, but merely has links to file sharing sites, such as bittorent, which allow web surfers to download such files.
Cyber Battles
Big brother in Israel?
Ariel Atias, Amir Hetsroni
Communication minister and academician debate internet censorship bill
Web surfers have noted that in the last few days they receive a 404 error message from their internet browser when they attempt to access the site, but no notice of the site's obstruction has appeared online as of yet.
"I order the respondents, that is Israeli internet service providers, to systematically block access to the illicit site, httpshare," wrote Haifa District Court Justice Gideon Ginat in his February 25th verdict, "so that surfers cannot enter this site and utilize it in in order to impede upon the claimants' copy rights."
The judge did not set a timeframe for this expected shut down, or indicate how long access to the site will be blocked.
Site operators: The battle has begun; the site is perfectly legal
Site operators in turn are attempting to fight back against this virtual shut out by changing the IP address of their website, but have reported that internet service providers have managed to block out their website even after they have made these modifications.
"The file sharing battle has begun…we'll be left with a world wide web that contains news alone," reads the site's homepage, which is now only partially available utilizing certain internet access providers.
Httpshare: The file sharing battle has commenced
According to site operator, who left a message to visitors frequenting their site's homepage, the site, "is perfectly legal. According to legal codes in the Netherlands, sites providing external links allowing surfers to download movie, music, games and program are perfectly legal. Sites cannot sites these illicit files on their internet servers, and that is precisely what we do not do. The site merely provides links to file sharing sites such as http:bittorent."
Moreover, site operators noted, "The website operates from the Netherlands, and the fact that is in Hebrew does not make it automatically subject to Israeli law! Israeli law applies only to Israeli residents and to websites operating from Israel itself."
IFPI: We'll go after international sites as well
Why have other Israeli websites not been blocked out by service providers? According to Moti Amitai, Director of the Enforcement Unit of the Israeli branch of the International Federation of the Phonographic Industry, "he IFPI has taken action against sites which operate from Israel and whose proprietors are Israeli."
In this particular case, notes Amitai, the site's operator seemingly lives abroad, and so this represents an entirely different scenario.
As for international files sharing sites, Amitai noted that "we want to utilize this verdict as a precedent and go after international sites as well. We are now looking into the logistics and the legal issues involved."


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The Super Bowl has really grown in prominence in recent years, resulting in more spending among viewers.
Super Bowl Sunday is now a sacred event in the U.S. calendar.
The highest-rated television event in the country really has people spending serious money. The National Retail Federation (NRF) forecasts that total spending will reach levels of $14.8 billion dollars this year as people spend on beer, TVs, meals and snacks.
On a per person basis, this year the average American is expected to part with $81, which is tied to 2018, representing the second-highest level of spending per person in the survey's history behind $81.19 set in 2016.
These numbers have peaked rapidly since 2010, when spending per person was just over $50.
The biggest spenders are those ages 35-44 at an average $123.26 while the lowest are those 65 and older at $40.97.
T.V. viewers in the Northeast plan to spend the most, at an average $94.89, followed by the West at $84.01, the South at $79.09 and the Midwest at $69.24.
The survey of 7,384 adults 18 and older was conducted January 2-9, before it was known which teams would play, and has a margin of error of plus or minus 1.2 percentage points.


Impression can change the trajectory of a relationship for a long time. Whether it's a better half, a company partner, a good friend– that very first interaction is vital.
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The Goldfinch has eye-catching black and yellow wings and a scarlet red face with black and white markings around the face. Their tails are black with white spots and the rump white. Often seen in large flocks.
These colourful birds enjoy seeds, split grains and some insects. They will also use a peanut feeder and will become a common visitor to your garden.
Greenfinches will nest in concealed spots high up in the bushes in a dead grass and small twigs.


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Sorquainville is a commune in the Seine-Maritime department in the Normandy region in northern France.

Geography
A small farming village, in the Valmont valley of the Pays de Caux, situated some  northeast of Le Havre, at the junction of the D75 and D33 roads.

Population

Places of interest
 The church of St. Martin, dating from the eleventh century.
 A chateau.

See also
Communes of the Seine-Maritime department

References

Communes of Seine-Maritime


Walrus, on the Northern Quarter's vibrant High Street bar and food scene, brings to the already thriving district, a funky, design-led environment, in keeping with the areas laid back aesthetic, but with the added polish to put it at the forefront of Manchester's bar scene.
The highly individual and psychedelic venue spreads across two floors and the feel is colourful, eclectic and stimulating; with design elements such as the wallpaper, coloured rubber flooring and lighting having been sourced from across the globe. The overall look creates an atmosphere akin that of a gallery, provoking a reaction and creating a talking point for customers.


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Heraldry in its most general sense encompasses all matters relating to the duties and responsibilities of officers of arms. To most, though, heraldry is the practice of designing, displaying, describing and recording coats of arms and badges. The origins of heraldry lie in the need to distinguish participants in combat when their faces were hidden by iron and steel helmets.
At the time of the Norman Conquest of England, modern heraldry had not yet been developed. The beginnings of modern heraldic structure were in place, but would not become standard until the middle of the twelfth century. By the early thirteenth Century, coats of arms were being inherited by the children of armigers. In Britain the practice of using marks of cadency arose to distinguish one son from another, and was institutionalized and standardized by the John Writhe in the fifteenth century.
In the late Middle Ages and the Renaissance, heraldry became a highly developed discipline, regulated by professional officers of arms. As its use in jousts became obsolete coats of arms remained popular for visually identifying a person in other ways—impressed in sealing wax on documents, carved on family tombs, and flown as a banner on country homes.
The idea that each element of a coat of arms has some specific meaning is unfounded. Though the original armiger may have placed particular meaning on a charge, these meanings are not necessarily retained from generation to generation. Unless the arms incorporate an obvious pun on the bearer's name, it is difficult to find meaning.
The development of firearms made plate armor obsolete and heraldry became detached from its original function. This brought about the development of "paper heraldry" that only existed in paintings. Designs and shields became more elaborate at the expense of clarity. The 20th century's taste for stark iconic emblems made the simple styles of early heraldry fashionable again.
The focus of modern heraldry is the armorial achievement, or coat of arms. The central element of a coat of arms is the shield. In general the shape of shield employed in a coat of arms is irrelevant. The fashion for shield shapes employed in heraldic art has generally evolved over the centuries. There are times when a particular shield shape is specified in a blazon.
Traditionally, as women did not go to war, they did not use a shield. Instead their coats of arms were shown on a lozenge—a rhombus standing on one of its acute corners. This continues to hold true in much of the world, though some heraldic authorities make exceptions. In Canada the restriction against women bearing arms on a shield has been completely eliminated. Noncombatant clergy have also made use of the lozenge as well as the cartouche—an oval-shaped vehicle for their display.
Tinctures are the colors used in heraldry. Since heraldry is essentially a system of identification, the most important convention of heraldry is the rule of tincture. To provide for contrast and visibility metals—generally lighter tinctures—must never be placed on metals and colors—generally darker tinctures—must never be placed on colors. There are instances where this cannot be help, such as where a charge overlays a partition of the field. Like any rule, this admits exceptions, the most famous being the arms chosen by Godfrey of Bouillon when he was made King of Jerusalem.
There is also a separate class of charges called sub-ordinaries which are of geometrical shape subordinate to the ordinary. According to Friar, they are distinguished by their order in blazon. The sub-ordinaries include the inescutcheon, the orle, the tressure, the double tressure, the bordure, the chief, the canton, the label, and flaunches.
Marshalling is the art of correctly arranging armorial bearings. Two or more coats of arms are often combined in one shield to express inheritance, claims to property, or the occupation of an office. Marshalling can be done in a number of ways, but the principal modes of include impalement and dimidiation. This involves using one shield with the arms of two families or corporations on either half. Another method is called quartering, in which the shield is divided into quadrants. One might also place a small inescutcheon of a coat of arms on the main shield.
When the helm and crest are shown, they are usually accompanied by a mantling. This was originally a cloth worn over the back of the helmet as partial protection against heating by sunlight. Today it takes the form of a stylized cloak or hanging from the helmet. Typically in British heraldry, the outer surface of the mantling is of principal color in the shield and the inner surface is of the principal metal. The mantling is conventionally depicted with a ragged edge, as if damaged in combat.
Clergy often refrain from displaying a helm or crest in their heraldic achievements. Members of the Roman Catholic clergy may display appropriate headwear. This takes the form of a galero with the colors and tassels denoting rank. In the Anglican tradition, clergy members may pass crests on to their offspring, but rarely display them on their own shields.
Supporters are human or animal figures placed on either side of a coat of arms as though supporting it. In many traditions, these have acquired strict guidelines for use by certain social classes. On the European continent, there are often less restrictions on the use of supporters. In Britain only peers of the realm, senior members of orders of knighthood, and some corporate bodies are granted supporters. Often these can have local significance or a historical link to the armiger.
If the armiger has the title of baron, hereditary knight, or higher, he or she may display a coronet of rank above the shield. In Britain this is usually below the helmet, though it is often above the crest in Continental heraldry.
Heraldry continues to flourish today in the modern day. Institutions, companies, and members of the public may obtain officially recognized coats of arms from governmental heraldic authorities. However, many users of modern heraldic designs do not register with heraldic authorities, and some designers do not follow the rules of heraldic design at all.
In Scotland the control of heraldry is fully legal and the Lord Lyon King of Arms retains powers—including imprisonment, fines, and defacement of illegitimate arms. His office has no equivalent in England and is closer to that of the Earl Marshal than that of Garter Principal King of Arms.
The Heineman Armorial Bearings are registered to Wilhelm August Heineman, late of Keokuk, Lee County, Iowa; the son of John Henry Heineman and Bertha Ann Heineman, nee Burger; recognized 16 January 1999 and entered in the Heraldic Register (American College of Heraldry) under Number 1778.
Per fess Gules and Azure a barrulet Argent, over-all an eagle displayed wings inverted Or, charged on the breast with a fleur-de-lis Azure. Above the Shield is placed a Helmet with a Mantling Gules doubled Or, and on a Wreath Or and Gules is set for Crest, a castle with two towers Argent the port occupied by a cross throughout Gules, and issuing there above three trees in Autumn tinctures Proper, and in an Escrol below the Shield this Motto: Leadership Through Service.
A "fess" is associated with the military girdle and belt of the ancients and their nobility. The red, white, and blue shield colors were chosen to signify American service. The eagle has a number of meanings. The surname Jensen is a variant of the "son of Jens" or the "son of John." Usually this has an ancient allusion to respect for St. John, who is represented by the eagle in ancient and modern religious iconography. The eagle with turned-down wings alludes to Germanic ancestry. The fleur-de-lis on a golden background (a reversal of the ancient French flag colors) alludes to Wilhelm's military service for the United States in France as part of the Allied Forces during WWI. The fleur-de-lis is representative of the Crum family origins. The fleur-de-lis is an adaptation of the lily, generally recognized as one of the most highly regarded charges with those of royalty and nobility. The three leaves of the fleur-de-lis represent courage, faith, and wisdom.
The proper helmet of a gentleman's coat of arms is the "tilting" helm.
A wreath or torce is common in early arms. The castle in the crest alludes to the Burger (meaning dweller in a castle or town). Growing from the castle is a grove of trees, alluding to the Heineman name meaning a man who lives in or protects a grove or forest. The trees are in Autumn colors to keep from clashing with the other tinctures. The cross on the castle port is of Germanic design referring to the Christian faith.
The motto represents the family's dedication to service organizations and their leadership roles.
The bearer of a coat of arms is called the Arminger (Wilhelm August Heineman) and the arms are passed to the male heirs in direct lineage. The following individuals have rightful use of these arms: Lucille Ann Dodson, Peter Edward Heineman, Sharen Lee Heineman, Bim August Heineman, Peter Lea Heineman, Chad August Heineman.
The following are representative of some of the coat of arms used by ancestors of the Heineman family.


Toyota is seeking a Consultant of Process and Standards in Dallas, TX.
The goal of the TMNA IS PMO is to improve the success rate of individual projects and programs as well as optimize the portfolio of projects to support Toyota's strategic objectives. Consultant (Process, Standards COE) will work together with the Technology Manager (PMO Process, Standards and training) to deliver foundational processes, standards, and training to meet the needs of projects and programs.
Consultant – Process and Standards COE is responsible to work with the team of consultants and variable work force to perform research and analysis to understand PMO industry best practices and it's applicability to TMNA IS projects/programs to deliver pragmatic and nimble processes, standards, and training that is aligned to Toyota culture. Candidate should have ability to work with TMNA IS team members, other PMO members and clearly communicate PMO vision and service offerings to the IS management team.
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We are pleased to announce the release of our debut album Diaspora : Explorations in Tele-Improvisation through the Chilean net label Peublo Nuevo released 16.12.14.
Diaspora is a compilation of live freely improvised performances by Ethernet Orchestra recorded between 2009-2014. It features musicians from a diverse range of cultures and musical traditions performing simultaneously between Iran and Australia via North America, Brazil and Europe. The ensemble combines an array of instruments including Mongolian horse fiddle & throat singing, tabla, Persian tanbur & tar blended with Buchla synthesizer, guitar, trumpet, sax and Max/MSP processing.The majority of the recordings are from performances with live, online, and co-located audiences. Many of these performances also included visual artists Helen Varley Jamieson, Neil Jenkins, Graziano Milano and Michael Szpakowski mixing live visual collages in the networked audiovisual platform VisitorsStudio. These mixes can be viewed from the menu above.
Performing musicians include; Mark Francombe (NO) – guitar Bukhchuluun Ganburged (MN) – morin khuur & throat singing Richard Lainhart (US) – buchla 200e, haken continuum & guitar Roger Mills (AU) – processed trumpets Hervé Perez (FR/UK)- soprano saxophone & electronics Shaun Premnath (MY/ AU) – tabla Peyman Sayyadi (IR, CA)– tanbur, Martin Slawig (DE) – processed percussion & electronics Aref Toloei (IR)– tar Yavuz Uydu (TR/AU) – oud, bendir Elke Utermöhlen (DE) – processed voice & electronics.
During this period we also had the great fortune to collaborate with the late Richard Lainhart, who is featured on many of the recorded improvisations. Ethernet Orchestra would like to dedicate this album to Richard whose passion and generosity lives on in these recordings. Thanks also to Richards wife, Caroline Meyers for the sleeve design.


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This empire silver pot belly sterling silver baby cup is a cherished collectible for families to treasure for generations to come. The cup features a luxurious bead trim just below the rim, is polished to a gleaming finish, and is perfect for engraving with a meaningful monogram or date. Accented by a scrolled handle and signature bulged shape, this sterling baby cup will delight the parents as much as the baby. Comes packaged in a gift box with a protective fabric pouch. Measures 2-1/8 inches high and 2-3/4 inches in diameter.


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Gbely (German and Hungarian: Egbell) is a town in the Skalica District, Trnava Region in western Slovakia, close to the Czech border.

History
The first written record about Gbely was in 1392. It gained town rights in the 16th–17th centuries. Petroleum was discovered in 1912 and extraction started in 1914.

Geography
Gbely lies at an altitude of  above sea level and covers an area of . It is located in the Záhorie region, in the Chvojnická pahorkatina hills, around  from the district seat Skalica and  from the Slovak capital Bratislava.

Demographics
According to the 2001 census, the town had 5,223 inhabitants. 96.09% of inhabitants were Slovaks, 1.26% Czechs 0.96% Roma, and 1% Amit. The religious make-up was 83.40% Roman Catholics, 14.57% people with no religious affiliation and 0.69% Lutherans.

Notable Resident
Matej Kocak (1882–1918) Slovak-American World War I Medal of Honor recipient was born here.

Twin towns — sister cities

Gbely is twinned with:
 Židlochovice, Czech Republic
 Deutsch-Wagram, Austria

See also
 List of municipalities and towns in Slovakia

References

Genealogical resources

The records for genealogical research are available at the state archive "Statny Archiv in Bratislava, Slovakia"

 Roman Catholic church records (births/marriages/deaths): 1710-1904 (parish A)
 Lutheran church records (births/marriages/deaths): 1786-1895 (parish B)

External links

 Town website
Surnames of living people in Gbely

Cities and towns in Slovakia


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With the rapid pace of technological change, comes no shortage of issues for website owners.
As mobile phones have become increasingly advanced, mobile internet use has grown accordingly. In fact, the rate at which mobile users is growing is actually quite staggering.
Additionally, Google recently started moving some sites over to its long-awaited mobile-first index.
So now, more than ever before, it's pretty much a requirement that websites be optimized for mobile (mobile-responsive).
The benefits are nothing to shake a stick at.
That's right, mobile optimization can absolutely impact your SEO and sales. The verdict has been in for a while in fact.
All the way back in 2015, Google rolled out their "Mobilegeddon" update that aimed to deprecate non-mobile-friendly websites from mobile search.
While the effects weren't as damaging as many feared, it's nevertheless clear that it had an impact.
If you want to see the data, check out these case-studies by Lunametrics and Scorchsoft. They clearly illuminate the effects going mobile-friendly can have on your SEO and organic traffic.
So it's clear that being mobile optimized matters. But what exactly does it mean, and how can you reach the goal line?
Of course, you probably get the gist of it.
At the most basic level, all being mobile optimized means is that your website is intuitive for users to engage with on a mobile a device.
But more specifically, you might be left wondering what to watch out for.
There are of course, obvious infractions. These might include things like a horizontal scroll bar, or misformatted imagery and spacing.
But there are also less obvious errors that might include hover-over tooltips or features that are lacking on mobile devices, etc.
So in order to get optimized, you'll primarily want to focus on ensuring your content is easily accessible to users on both desktops and mobile devices.
Before we go and fix anything though, let's find out if it's even broken in the first place.
Since Google is invested in making the web more user-friendly, they've gone ahead and built an all-inclusive free tool to test for mobile responsiveness.
Simply use their Google Mobile-Friendly Test to quickly determine if your website has a mobile-friendly version in action.
It's not foolproof, but it's a good starting point.
As you can see in the above example, it's possible that Google will sometimes determine that a page is mobile-friendly, but at the same-time show a broken example on the right side of the screen.
Don't get too hung up on it.
If it's saying that your page is mobile-friendly, you're likely in the clear. But it makes sense for you to test it out on your own mobile device just to be safe.
Also, remember that if you very recently made mobile-responsive changes, it can take a little time for Google to recrawl certain websites. So if you want to be on the safe side, click "Submit to Google" after your changes manage to obtain the "page is mobile-friendly" approval.
Another tool that you might find useful is LambdaTest. You can leverage their platform to test your website on a variety of different devices, browsers, and screen sizes. All from within your own browser.
We use LambdaTest regularly and definitely recommend it as a more in-depth way to test websites for mobile-friendliness.
Remember, mobile-responsiveness is simply one part of the mobile optimization puzzle.
It's also worth looking at your page speed on mobile devices to determine if your website is truly mobile optimized.
Google PageSpeed Insights is a powerful (and free) tool that scores how fast or slow your website loads on desktop and mobile.
More specifically, it will identify problem areas so you or your developer can easily take action to improve load times.
So we've covered how to determine if your site is mobile optimized or not, and we touched on why it's important.
Now we need to get to the meat of the article. How to get mobile optimized.
There's a lot to cover here. First and foremost, you'll need to decide how you want to display your website for mobile users.
There are three ways you can do this. Each with varying degrees of difficulty and development time required.
First and foremost, it's worth noting that while Google supports all three, they prefer this method.
Thus, implementing a responsive design is one of the best ways to optimize your site for mobile users.
As we covered earlier, responsive design essentially means that your site's layout will adapt to a multitude of resolutions.
This in turn enables users to easily navigate your website regardless of the device they're using to access it.
Now, lucky for you non-developers out there, most CMS platforms offer free responsive themes that are easy to download and install.
Website builders like Weebly, Wix and Squarespace are mobile-responsive by default. And WordPress has tons of responsive options in their theme directory.
These are accessible from your WP dashboard, and don't necessarily require any coding knowledge.
For custom websites however, you'll likely need to reach out to your web designer/developer in order to implement responsive design.
If you're feeling adventurous however, you can try your hand at it of course. Maybe start out with this short tutorial on 1st Web Designer.com.
If you don't want to (or can't afford to) invest in responsive design, you could alternatively consider serving dynamic content.
This is done by detecting the type of device being used by any website visitor, and serving a different set of HTML and CSS depending on what comes back.
There are a few circumstances in which this might be effective, but generally it's more trouble than it's worth. For starters, you'll need to keep a constantly updated/curated list of user-agents, which can be quite the hassle.
Additionally it's not unheard of for users on either desktop or mobile to be served the wrong version accidentally. This would obviously result in a poor user experience.
But if this is the right approach for you, here's a deep-dive on the VaryHTTP header, which is the method you'd want to employ.
The third and final way for you to consider serving mobile content, would be to set up a second site/page for mobile users.
This would circumvent the need to customize responsive code, but requires that you be very careful and thorough with your 301 redirects.
If you decide to make an entire parallel site experience for mobile users, be sure to include a rel-canonical tag, and clearly delineate between the two in terms of URL structure. Many site owners taking this approach will create an "m" subdomain.
Remember, this method is as equally problematic as serving dynamic content. If you choose route, be sure to make it easy for users to "choose" the alternate version of the site, in case they're served the incorrect one.
While the last step likely required your developers and designers to be involved, the following optimizations may be possible without technical expertise.
Of course, it would be wise to have a web designer and developer on hand regardless.
This may sound the same, but actually differs from using responsive-design principles.
What we mean by design for mobile is this… for the mobile version of your content and landing pages, make sure that you consider a few key points.
Mobile users have to touch the screen with their fingers, which are sometimes quite large in proportion to on-page elements.
So try to make sure that it's difficult for users to "fat-finger" page elements. Enlarge buttons, remove hover-effects, etc.
Also, remember that the vast majority of mobile devices won't support Flash. So avoid Flash at all costs. Just use HTML5 or CSS for any animations you want to add to pages.
Last but not least, make sure that your site navigation makes sense with only a hamburger menu icon at the top.
Since there isn't nearly as much screen real-estate to work with on mobile devices, you won't have all of those handy header links clearly visible like you would on desktop.
So try to ensure that your site structure makes sense for users accessing it via mobile phones and tablets.
Site speed and mobile-optimization go hand in hand.
Luckily, if you've employed mobile-responsive design, you've already got a leg up on this one.
In general, the mobile version of websites will usually require fewer resources than their desktop counterparts. But that doesn't mean you're out of the woods.
Your first course of action, is to run a site speed test (like we described above), and take a look at your mobile load times.
The next item on your to-do list, will be to prioritize the tips provided, and get to work.
To get a full walk-through on how to improve site speed, you can check out our guide on the subject here.
Additionally, if you're on WordPress, we also compiled a list of the best WordPress plugins to help improve your load times.
If you're not on WordPress, don't panic. Just take a look at the list, and then search for comparable options that are available for your CMS.
No one likes full-screen interstitial ads. But in 2018, they're still part and parcel to online advertising.
So if you're employing them on your website, we don't blame you (though we might throw some shade your way).
Google has been very clear however, that they believe interstitials are more egregious to the user experience on mobile devices than on desktop computers. More importantly, these intrusive ads will actually hurt your rankings.
Here's an article covering the topic in greater detail.
And let's be honest, who can blame Google for taking this stance? If you've ever browsed the web on your phone, you likely know why they did.
Often, these interstitials are misformatted. Sometimes the button to close them is missing due to a screen size issue. The list goes on and on.
Even if you're sure that yours are going to show correctly, it's best to disable them for mobile visitors entirely.
In case you didn't pick up what we've been laying down, the world has gone mobile.
So now more than ever before, every website owner should take a good hard look at their mobile optimization.
If you're going to maintain your rankings and grow traffic, you'll want to make sure you have a mobile-friendly version for all of your most important landing pages and content.
With any luck, following our advice above will help you get started on the right foot.
This guide is by no means exhaustive, and there are plenty of other angles to consider. But we're confident that it's the best place for you to start.
It's hard work, to be sure. But in exchange, you'll earn more traffic, lower your bounce-rates, and ultimately improve your conversions.
Mobile optimization is the art (or science if you prefer) of ensuring your website will function correctly and intuitively on mobile devices.
Why is mobile optimization important?
It's important because these days, it's extremely common for users to browse websites on their mobile devices. If your site isn't mobile optimized, users will bounce and you'll miss out on valuable leads and sales. Further, search engines take mobile optimization into account in their ranking algorithms.
How to do mobile optimization?
There's no fast and easy way to mobile optimize, but you can start by using a mobile responsive design. Also be sure to speed up load times, consider using accelerated mobile pages (AMP), and design content with mobile-users in mind.


Despite the heat, we decided to rent bicycles to get around Key West. Mopeds and electric cars are also very popular rental items. In the morning, we took a long ride all the way around the key. We got a little overheated, but refreshed ourselves at Camille's restaurant, a funky local favorite. Then it was off to rent a sailboat for an hour. I wanted to rent their Hobie 16, but they were a little lazy, since it wasn't rigged yet; so they talked us into the Hobie 14. It was fun to be on the warm water. Hobie sailing is definitely a wet experience, so it is obviously not a Puget Sound favorite. Esther enjoyed laying on the trampoline and getting splashed with warm water. In the evening it was back down to Mallory Square to enjoy the sunset. Tomorrow, we head back to Miami.


Have you decided that you want to start to make some changes in your life to get healthier? If this is the case, you might not know where to begin. There is nothing wrong with this. There are many other people who are in the same situation. You just need to figure out where to go in order to learn different ways to get healthier. You need to make sure that the info you are getting is coming from a good source who knows what he or she is talking about. This will ensure that you are actually helping your body and not harming it. Here are some of the most ideal places to get healthy lifestyle info.
1. Pay a personal trainer to create a workout regimen for you to follow.
You probably want to start working out. However, this is not something you should jump into without the proper instructions. This is especially true if you have never exercised on a regular basis before. You need to be taught various stretching techniques that will prevent you from pulling a muscle. Therefore, you need to get in touch with a person who makes a living as a personal trainer. This person has a license to train people and teach them various fitness techniques. He or she will see how fit you are right now. The trainer will then create a fitness program that is designed just for you. Your personal trainer will exercise with you and make sure that you are not straining yourself. He or she will also show you the proper way to perform various exercises so you do not develop an injury.
2. Enroll in a class that will teach you about health and nutrition.
It would be in your best interests to learn as much as you can about all of the various aspects of health and nutrition. A great place to start is at a community college. Most of these schools offer a large selection of health and nutrition classes for you to choose from. Call the school and find out exactly what will be taught in each class. This will help you to determine which class will be the best fit for you. You might also want to visit health365 for glucosamine and some of the other supplements they sell. These can help to improve your overall health.
3. Speak to friends or family members who know a lot about living a healthy lifestyle.
There is a good chance that some of the people you know work out on a regular basis. These people might also have some knowledge about nutrition and eating healthy. It will not cost you anything to pick their brains and get advice from them regarding how you can become healthier. These people love you and will be more than willing to give you the guidance you are seeking.
4. Search for blogs that are related to health and fitness.
There is a wealth of info about health and fitness that is available online for free. You just need to spend some time looking for it. The amount of fitness blogs is enormous. Therefore, it should not take you very long to discover a large selection of blogs that will give you useful info.


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All images, graphics, files, texts and other content on this website are protected by copyright, registered trademarks or other intellectual property rights. The copying, publication, processing or other use in electronic media, by other websites, print media or in other ways, whether for private or commercial use, requires our prior written consent, to which there is no entitlement.
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Anthony Varga (left) with Jassy Hundal, United Way.
Endress+Hauser solicited employee contributions from March 4-18, with a milestone goal of donating $15,000 to the United Way — $7,500 from employees and $7,500 in a matching donation from the company.
The goal was exceeded: $16,714 was raised — 50 percent came from employees and 50 percent from the company.
Funds raised will go directly to the communities where Endress+Hauser staff are located: Montreal, Burlington, Edmonton and Calgary. Endress+Hauser employees also are being encouraged to volunteer their time throughout the year during company hours to support local United Way initiatives.
The helping hand United Way extends nationally encompasses an essential network of programs and services designed to achieve lasting, positive change, whether the need is created by poverty, mental or physical challenges, loneliness or isolation. United Way programs show people a way out of despair to a better today and tomorrow.
The territory served by the United Way Halton & Hamilton covers communities around the western end of Lake Ontario, including Burlington, where Endress+Hauser has had its headquarters since opening its doors in 1990. Though this part of the Golden Horseshoe is often described as one of the most affluent parts of Canada, the United Way serves over 212,000 vulnerable children, families and seniors in Halton region.


Generally, each person in the world has their own individual life experiences and courses founded upon the choices they make whenever they are faced with a definite encounter or circumstance with another person or even in class. Each individual reacts in a different way on these incidents as part of the personality complex of the human character. On the other hand, analogous on all occasion, each person can learn a significant lesson from each of these circumstances or encounters which are vital to their personal progress. If an individual is sufficiently willing as well as is open towards the scenery of familiarity, he or she can be effectual as well being enlightened by the moral meaning of the event. Thus, throughout the concrete experience of every individual that he or she learns to build up and advance into a better human being.
With regard to this aspect of life known as learning, I intend to relate an important learning experience in class from where I learned an important lesson that I still grip to the present. From this experience, I have realized the value of time; that it only accords a single chance for a person to succeed in a sitution for a moment. According to a proverb by the wise that time is valuable as is the worth of gold. In the stretch of time, every second is crucial and incessantly passing, and if wasted will never come back. Thus, it is imperative to offer magnitude to each single instance of it. During my entire duration in class I was used to instances of depending on second opportunities in which if one opportunity is shattered then an extra is provided. This is a definite privilege that I have always got pleasure from throughout all my experiences and predominantly in class.
My educational facilitators as well as my teachers have always given me a privilege or even handicap due a variety of private reasons such as my excellent manipulation of words, my family background, as well as my social pressure on others. It is as if the providence of chance was laid upon my hands thus permitting me to have control over time and odds for my own individual achievements. Nevertheless, this has taught me a negative lesson on which I became used to the privilege to a point of misuse. Certainly, the errors of my ways have walloped back unpredictably leading to a catastrophic ending.
A significant exam essential for my overall educational performance had come and as all the time, I by no means paid no interest to it in spite of of the time restraint for the examination preparation period. I consider this task at its explicit period to be inconsequential because of my anticipation for special exclusion. Conversely, past my knowledge, the administrator for the exam came from another institute on which he had no control whatsoever over us therefore, negating my entire privileges. I was forced to take the exam at this particular period despite having no enough time to prepare.
This particular experience, which turned out to be the best and the worst in my life, substantiated to me that it is at all times possible and necessary to find strengths to surmount intricacies and change bad into excellent. Class experiences are associated with much anxiety but also happiness as well. They make us reflect on why we subsist in this life. They transform our values, our life and our style. They turn us into more persistent and responsible people. Thus I am prepared for yet another thrilling, life changing class experience.


Creek Technologies Co., Beavercreek, Ohio (N00244-16-D-0009); General Dynamics Information Technology, Fairfax, Virginia (N00244-16-D-0005); Digital Consulting Services, Newbury Park, California (N00244-16-D-0006); DeVine Consulting Inc., Fremont, California (N00244-16-D-0008); and MAC Consulting Services Inc., Fairfax, Virginia (N00244-16-D-0007), are being awarded an estimated $87,996,380 multiple award, indefinite-delivery/indefinite-quantity, cost-plus-fixed-fee, task order contracts to provide a variety of teaching, research and subject matter experts to support various educational programs for the Naval Postgraduate School. Each contract includes a one-year base period and four year option periods. If all options are exercised, the contract value will reach a ceiling value of $502,670,476. Work will be performed in Monterey, California (95 percent); San Diego, California (2 percent); Washington, District of Columbia (2 percent); and Norfolk, Virginia (1 percent). Work is expected to be completed by March 2017; if all options are exercised, work will be completed by March 2021. Fiscal 2016 operation and maintenance (Navy) funds in the amount of $1,000 will be obligated on each of the five contracts to fund the contract's minimum amount and will expire at the end of the current fiscal year. This contract was competitively procured with the solicitation posted to the Navy Electronic Commerce Online website, with seven offers received. Naval Supply Systems Command Fleet Logistics Center San Diego, California, is the contracting activity.
The Boeing Co., Huntington Beach, California, is being awarded $13,381,495 to exercise a cost-plus-incentive-fee option to a previously awarded contract (N00178-15-C-2016) to continue to provide design agent and technical engineering services in support of the AN/USQ-82(V) Gigabit Ethernet Data Multiplex Systems (GEDMS) program. GEDMS is a shipboard network used for DDG 51 class destroyers. The GEDMS network transfers inputs and/or outputs for the machinery control systems, damage control system, steering control system, AEGIS combat system, navigation displays, and interior communications alarms and indicators. It was designed to replace the mile of point-to-point cabling, signal converters, junction boxes, and switchboards associated with conventional ship's cabling. GEDMS is being forward-fitted on DDG 51 new construction, back-fitted to Flight I/II DDG 51-78 and Flight IIA DDGs 79-107, LHD Capstone ships and AEGIS Ashore installations. This contract combines purchases for the Navy (91 percent); and the governments of Australia (3 percent); Korea (3 percent); and Japan (3 percent), under the Foreign Military Sales program. The work will be performed in Huntington Beach, California (72 percent); Arlington, Virginia (11 percent); Bath, Maine (9 percent); Pascagoula, Mississippi (3 percent); Georgetown, District of Columbia (3 percent); Richardson, Texas (1 percent); and Fairfax, Virginia (1 percent), and is expected to be completed by March 2017. Fiscal 2016 operations and maintenance (Navy); fiscal 2010 shipbuilding and conversion (Navy); and foreign military sales funding in the amount of $840,589 will be obligated at time of award and will not expire at the end of the current fiscal year. The Naval Surface Warfare Center – Dahlgren Division, Dahlgren, Virginia, is the contracting activity.


Cartier Mens Engagement Rings not too bad at all I ll wear it – And not theoretically just as rough and thus scratch-resistant when a diamond, moissanite definitely occurs relatively close. For a 9.25 along the Mohs level about mineral hardness, moissanite is without a doubt subsequently and expensive diamonds regarding other jewels, and is accordingly quite difficult to be able to destruction as well as scratch. If you find yourself comparing and contrasting the two and also visit using the made to be more scratch-resistant, the two boulders can be equivalent from this arena and then would likely end up rather inclose which will competition.


Animal Farm Cafe at Hatfield Open Farm01707 895443work CafeEnjoy lunch at the animal cafe with a great range of food and drink to choose from, your spoilt for choice!
Food is served between 12am and 3pm however drinks are available all day.
Enjoy lunch at the animal cafe with a great range of food and drink to choose from, your spoilt for choice!
You can eat in or take out food to enjoy in our picnic area, pack lunches are available for all ages.


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Nana Addo Meets Ghanaian Media In North America
October 23, 2015 Webmaster	0 Comments	election2016, Kwaku Kyei Ofori, Nana Addo Dankwa Akufo Addo, NPP, NPP New York, NPP-USA, press, Washington DC
The flag bearer of Ghana's opposition New Patriotic Party, Nana Addo Dankwa Akufo Addo has met with the Ghanaian media in North America in Washington DC. The event, organized by the New Patriotic Party's USA Branch (NPP-USA) was a one hour affair in which journalists coming from radio, internet and TV establishments were invited. The pressmen and women were given an hour to ask questions and seek clarity on a number of issues.
In a response to the trending issue of the NPP's call for a new voters' register, Nana Addo said he does not expect the Electoral Commission to deny Ghanaians that basic right. He said several African countries, some less accredited in democratic governance than Ghana, have undertaken similar exercises to clean out their register.
"The arguments that have been made about the bloated register and the need to have a more accurate, reliable register are irresistible", he said.
He said the governing National Democratic Congress is the only body protesting the demand for a new voters register and this raises red flags.
A participant asking a question
He also addressed the issue of party unity and internal wrangling. Nana Addo said the information reaching his office and what he personally sees on the ground do not point to a divided party but rather one that is poised to wring power from the NDC. H said the John Mahama-led administrations mismanagement of Ghana's economy is enough of a rallying cry for all members of the NPP to bond tighter to change the fortunes of not just the NPP but for Ghanaians as a whole. The way in which John Mahama and his government have ruled and governed Ghana and managed our affairs, if we allow them another term we are committing generation of Ghanaians to a future of hopelessness.. and I believe that beyond everything else, that is the unifying factor for the NPP" he said.
Nana Addo also answered questions from some participants who joined the Press Conference via the internet.
Convener of the event, Kwaku Kyei Ofori who also doubles as the Communications Director for NPP-USA told ghnewsnow that this will be a regular feature till election 2016. Hee said the NPP will use all available avenues to avail the flag bearer to different facets of the electorate and the Press.
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