It will be hotter. It will be drier, at times, and wetter at others. We'll get less water from the Sierra Nevada snowpack, and the Pacific Ocean will rise and creep inland. But beyond those brute certainties, scientists, futurists, technologists, and entrepreneurs offer competing visions about how climate change will affect California in the decades to come.
Average present-day snowfall in the Los Angeles region. Photograph by Bob Bernal; rendering by Jacob Cooper, Climate Resolve.
If we choose to do nothing, the nightmare scenario plays out something like this: amid prolonged drought conditions, wildfires continuously burn across a dust-dry landscape, while potable water has become such a precious commodity that watering plants is a luxury only residents of elite, gated communities can afford. Decimated by fires, the power grid infrastructure that once distributed electricity—towers and wires—now loom as ghostly relics stripped of function. Along the coast, sea level rise has decimated beachfront properties while flooding from frequent superstorms has transformed underground systems, such as Bay Area Rapid Transit (BART), into an unintended, unmanaged sewer system.
Short of the nightmare, realistically, California, like the rest of the world, will see temperatures rise over the next four decades. The California Climate Change Center predicts a rise in average temperature ranging from 1.8 degrees to 5.4 degrees by mid-century. By contrast, annual average global temperature increased a relatively moderate 1.8 degrees over the preceding 150 years, according to the National Oceanic and Atmospheric Administration. Some areas in California, inland and in the deserts, will get much hotter, with many more super-hot days in the summer.
The sea level will rise along the coast. Polar ice melt-off combined with ocean water that expands in volume as temperatures rise will produce sea level increases from 5 to 24 inches south of Cape Mendocino, and up to 19 inches north of this geo-tectonic pivot point, according to recent simulation models produced by the Ocean Protection Council. The rising ocean will wipe away beaches and wreak havoc on some shoreline communities and infrastructure.
San Francisco Bay Conservation and Development Commission Executive Director Larry Goldzband warns of the damages that could result from a bad weather trifecta in the Bay Area. "What happens if you get increasing sea level, a huge storm, and king tides, which happen when earth, sun, and moon come into alignment, all at once?" he asks. "Water from the bay spills into the city." The Adapting to Rising Tides project predicts that the low-lying Oakland International Airport would be exposed to three or more feet of flooding during storm events with 16 inches of sea level rise.
Potential impact of global warming on snowfall in the Los Angeles region by 2050. Photograph by Bob Bernal; rendering by Jacob Cooper, Climate Resolve.
To the flooding, add fires. California's three worst fire seasons have all occurred within the last ten years, according to the California Office of Environmental Health Hazard Assessment. Higher heat fosters tinderbox-like conditions that exacerbate human- and lightning-caused flames.
California's water supply, much of it sourced from snow pack in the Sierra Nevada, will decline. UCLA Institute of the Environment and Sustainability Director Glen MacDonald points out that roughly 80 percent of the state's water is used to grow food. "When water becomes more scarce because of higher rates of evapotranspiration, how much water will we shift from our fields to our city?" he asks. Wherever our food will come from, it could be more expensive and there may be less of it.
Warmer temperatures also translate into a shorter winter chill period that farmers count on to grow fruit and nuts in the Central Valley. The delicate balance of sunlight and mild temperatures that fostered ideal conditions for Northern California grape growers could be thrown out of whack. National Academy of Sciences research notes that vintners in Sonoma County and Napa Valley may be forced to relocate farther north as temperatures heat up.
There is a clean, green, utopian scenario. Gasoline-fueled gridlock becomes the stuff of ancient urban legend as freeways set aside zero-carbon lanes for hydrogen-fueled vehicles and bicyclists. Agribusiness responds to arid conditions with hyperintensive farming techniques fertilized by their on-the-farm organic waste byproducts. Houses and commercial buildings generate their own power supplies with solar-paneled roofing, so homeowners happily share kilowatt surpluses with neighbors on a networked energy grid as easily as Facebook users now share online content, restaurant and reading recommendations, and instant messages.
People will abandon their cars for other ways of getting around these green streets. In the Next 10.org study "Unraveling Ties to Petroleum," UCLA-based lead author Juan Matute points out that public infrastructure has for decades rewarded the one-person-per-gas-fueled car lifestyle with hidden incentives. Envisioning the day when $80,000 parking privileges might become commonplace, Matute notes that the "Lone Driver" model historically flourished because consumers did not bear the true cost of public space devoted to free or cheap parking. In the future, he says, "If we reduce incentives for people to park on the street and decide that parking has a cost, we'll probably see more transition to transit and ride-sharing." The "ride share" concept, stubbornly ignored since its origins in the 1970s, is already quickly gaining traction thanks to profit-motivated, peer-to-peer jitney services like Uber, Lyft, and Sidecar.
Matute produced a carbon-neutral scoping plan for Hermosa Beach pegged to the year 2075. "We assume a 95 percent transition to electric vehicles over that time period," he says. "That seems to be the way things are going." Since 2002, when GM crushed dozens of its experimental electric EV1 vehicles due to insufficient market demand, electric car fortunes have already rebounded, signaling a dramatic reduction in vehicular greenhouse gas emissions. In 2013 Tesla reported record revenues and announced plans for a lower-cost $35,000 electric car to supplement its Model S sedan. IBM's Battery 500 Project aims to design lithium-air batteries that would boost the ability of electric cars to drive without a charge beyond their current 500-mile limit.
The Environmental Protection Agency's 1970 Clean Air Act dragged car manufacturers kicking and screaming into a forced-innovation mode that put an end to the smog alerts and spared Californians the pollution-clogged scenarios currently facing Mexico City, Beijing, and other exhaust-drenched urban centers. In the twenty-first century, government-engineered carrot-and-stick programs aim to similarly spur private sector ingenuity.
While it's too late to halt climate change in its tracks, state government policy encourages entrepreneurs, businessman, technologists, homeowners, and consumers to get with the same low- and even no-carbon vision for California. The California Energy Commission's alternative and renewable fuel and vehicle technology program (created by Assembly Bill 118) invests nearly $90 million during the 2013 fiscal year to develop new transportation technologies, alternative and renewable fuels. California's renewable portfolio standards mandate that 33 percent of the state's energy production must come from renewable energy sources by the year 2020. The California Global Warming Solutions Act of 2006 mandates that greenhouse gas emissions be cut to1990 levels by 2020*. University of California, Los Angeles, researchers hope to wean Los Angeles completely from fossil fuels by then.
Smoke from the Rim Fire blowing east, as seen from the International Space Station on August 26, 2013. Photograph courtesy of NASA.
Many renewable advocates regard nuclear energy as a dead issue in California, where state law prohibits the building of any new nuclear plants. But a contrarian cadre of environmentalists, including Whole Earth Catalog founder Stewart Brand, believe in the potential of fourth-generation nuclear reactors. Following California's now-shuttered San Onofre reactor dysfunction and Japan's catastrophic Fukijama meltdown, anti-nuke investors, politicians, and citizens will need a lot of convincing. Oakland-based Breakthrough Institute's Michael Shellenberger, who produced a feasibility study on "How to Make Nuclear Cheap," contends that nuclear energy deserves a second look. "New reactors need to be safe, need to be modular, and they need to be efficient," he says—and he believes they can be.
So what will it be? The good news? Or the bad news?
Let's not sit around waiting to find out.
*An earlier version of this article stated that the California Global Warming Solutions Act mandated greenhouse gas emissions be 80 percent below 1990 levels by 2050. In fact they are to be cut to 1990 levels by 2020.
Image at top is of the Ivanpah Solar Power Facility in the Mojave Desert, shown here with the Primm Golf Course in the foreground. Photograph courtesy of Brightsource Energy.
California emits 1, 222,000 of Carbon Dioxide each day, that is 447 million tons a year, and the California Public Utility Commission is set to approve more Natural Gas Plants Why ? We need to Stop This Fossil Fuel, Global Warming Energy Policy and implement a Residential and Commercial Feed in Tariff through out the Nation, this petition, starts in California.


I'm a Yorkshire girl at heart, down to earth but passionate about everything I do. After studying and working as an Interior Designer for 10 years, I decided to move my creativity into the wonderful world of weddings, and to say I absolutely love it would be an understatement. I believe that when you're in love with what you do the results truly shine through. Design for me has always been about pushing the boundaries, focusing on the detail and creating something truly unique. For me, that's a key part in creating your wedding day.
As most of us do, I loved planning my own wedding. I planned and designed everything to the finest detail and loved every second. The day itself was amazing and all that we could have hoped for. Planning my own special day made me realise how much passion I had for weddings and so I decided I wanted to share that passion with other brides and grooms. I enrolled in the UK Wedding Academy diploma course to learn as much as I could about this fabulous wedding industry and become an accredited Wedding Planner.
My aim for Emily K Weddings is to help brides and grooms create a wedding day that is unique to you and reflects your relationship. At the end of the day, that is what your wedding day is all about! Wedding planning can be an adventure in itself. It is an amazing thing to do, but I know from experience it can be time-consuming, confusing and overwhelming. I'd love for you to enjoy it as much as I did, so let me take away the stress, giving you chance to focus on the enjoyment of your engagement. I am a firm believer that there should be no standard package wedding. Let's push the boundaries and create your own style for your unique wedding day.
Please get in touch if have any questions or fancy a cuppa and a chat about the services I have to offer. I'd love to hear all about you!


Sopoong Korean restaurant was established in 2011 in Malaysia. "Sopoong" means "Picnic" in Korean. According to Korean culture, when we go on a picnic, we get excited and pleased because we get delicious foods and spend valuable time with friends and family.
We serve authentic Korean food such as bibimbap, bulgogi etc.


Selected out of Blizzard annual ryegrass, Verdure has tremendous value for livestock grazing, haymaking and silage production.
Verdure provides consistent, predictable high yields all season long! Some producers have been told that there is little difference between ryegrass varieties. A look at data from Northern Georgia and Northern Alabama shows how many differences there really are! Verdure outscored all other varieties at the Starkville, Mississippi research station and in Marianna, Florida.
Dry Matter Yield in Lbs.
Moldboard plowed and rototille 1270d; to avoid stand loss 1.0 inch/acre irrigation on 3-31-07, 4-05-07, 4-12-07, and 4-20-07.
Fertilizer: Preplant: 50 lb N, 40 lb P2O5, and 60 lb K2O/acre.
Topdress: 50 lb N/acre after 1st, 2nd, 3rd, and 4th harvests.
*Complete trial data available upon request.
Stand of all varieties was > 90% except Brigadier (38%), Beef Builder III (74%), Maton Rye (60%) and NF65 Rye (82%).
Soil: Marietta fine sandy loam.
One of Verdure's key characteristics is its improved disease resistance. The University of Florida regularly evaluates ryegrasses for resistance to leaf spot, crown rust, and gray leaf spot. Each rating in 2005 showed Verdure to be significantly more resistant than most all varieties!
* - Disease complex rating: 0 = no disease and 10 = 100% coverage or death. For the first two rating dates Gray Leaf Spot was the dominant disease, while Crown Rust was prominent during the last two ratings.
# - Disease was evaluated on the re-growth following a Feb 22 cutting. Complete results available upon request.
For optimal performance, prior to planting, obtain a soil test. Amend soil according to recommendations and fertilize after planting according to recommendations and use. Optimal pH Range is 6.0–7.0.
Verdure can be planted throughout the year. However, maximum utilization will be obtained by planting in the fall as soon as adequate moisture is available. If planted at other times of the year, performance will be limited.
Verdure can be drilled or broadcast into either a prepared seedbed or an existing sod bed. For prepared seedbed, lightly disc and pack well. For existing sod bed, reduce existing sod height as much as possible.
Application of fertilizer (following soil test recommendations) throughout the growing season and/or use of legumes will provide maximum forage tonnage and root growth.


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Star Citizen is in a lot of trouble (if you didn't know that already)
Tarryn van der Byl· 6 May 2019
Expected to launch in 2014, then 2015, then 2016, then who even knows but maybe the Squadron 42 beta will be out in 2020 until it isn't, Cloud Imperium Games' space sim is back in the news with claims from studio employees and contractors that the game's development is a total mess. Pretend to be surprised.
According to Forbes, CIG boss Chris Roberts is the problem, citing allegations of micromanagement, incompetence, and creative indecision, an ever-expanding project scope, and the use of Star Citizen's almost $300 million budget – funded through Kickstarter and polygon purchases – to keep pushing out demos and celebrity-stuffed trailers, and not the actual game. Awkward.
"As the money rolled in, what I consider to be some of [Roberts'] old bad habits popped up—not being super-focused," explains Mark Day, whose company was worked on the game in 2013 and 2014. "It had got out of hand, in my opinion. The promises being made – call it feature creep, call it whatever it is – now we can do this, now we can do that. I was shocked."
Over 100 people have complained about the game to the US Federal Trade Commission, with refund requests for as much as $24,000.
"The game they promised us can't even barely run," says one player. "The performance is terrible and it's still in an 'Alpha' state. I want out. They lied to us."
But hey, don't let that stop you from buying this $1,650 spaceship to fly in an unfinished galaxy.
GG: The problem with Star Citizen
Star Citizen's single-player campaign, Squadron 42, is now scheduled for deployment in the second half of 2020
Star Citizen's new trailer banks almost $1 million more from suckers, I mean fans
Crytek is suing Star Citizen developer Cloud Imperium Games
Maneater is bad for sharks, but it does look stupid fun

redpajama_set_name: RedPajamaCommonCrawl


In the wake of last week's terrorist attack in Boston and other tragedies, I decided to dig into the archives for a song with a helpful message. Responding to evil and disaster is a difficult and sensitive topic. It is at least part of the biggest reason why people choose to turn their backs on God. Why devote yourself to a Being that allows so many bad things to happen in this world?
The elusive answer to this question has been written across history for centuries. Merely stepping back and getting a bird's eye view will show that these tragic events are not new, nor are they an indication of what is to come. However, we ought to admit the fact that it is hard to remember this ageless cycle of violence when we are hit in the face with a new wave of evil's thorns. It feels so unnecessary, uncalled for, and unimaginable. The amount of "how" and "why" questions that I heard asked throughout the last few days reflects this challenge.
Therefore, I've called upon a voice from the past to encourage us with the old, but ever-new message: forget the past, and prepare for the days to come.
The Seventy Sevens (77s) dominated the rock scene throughout the 80's and into the 90's. Led by front man, Michael Roe, they began as a ministry-based quartet. Their integrity of both musical style and lyrical power lifted them into the hall of fame of Christian rockers (if there is such a place). I certainly cut my teeth on their sound in my early years. Like a surprisingly large amount of 80's bands, they still play and tour even today and you can listen to their entire discography at the link above.
The "days to come" obviously refer to the promise of Heaven and all things being made new in Christ. It is the time when the kingdom of God comes to reclaim and remake everything that was once lost and broken. The crux of these future days, as it relates to current evil, is that God has promised to put an eternal end to every evil, every sorrow, and every tear – for those who are found to have true faith in Jesus.
The informed Christian sees the news headlines from last week and thinks, "Come, Lord Jesus!" And this is all well and good, but the fact remains that Jesus didn't pick yesterday to return and rescue His people from woe. That day is still to come. Today is still a day filled with pain, regret, anger, restlessness, loneliness, and fear. What can we say the grieving and hurting people who need help?
The bottom line, as insensitive as it might sound, is these things are simply the inheritance of our human ways. Yes, there are positives to be celebrated from last week, such as the heroes who helped the injured, saved lives and captured the bombers. And yes, we are not all like those who would destroy innocent life for any reason. But, our human heroes are not our saviors; and our bombers are still our neighbors and fellow sinners before the Cross. All of the "how" and "why" questions are found in each of our hearts.
Do not be surprised by the clutches of evil in this world, for as severe as it seems at times God is actively holding evil at bay. Do not linger upon the tragedies of the past, for they will repeat themselves again and again until the White Horseman rides down from the clouds. And do not lose hope amidst the ashes of this world, for there are better days to come.


Silent Partner has a strong track record of customer satisfaction with many repeat customers and positive referrals. What stands out for consumers is Silent Partner's willingness to stand by the products and work through issues. Steve is always happy to help our customers find the best solution.
"I have the old Silent Partner Lite and I love it. As a grown man with a full time job and a family, I sometimes go months without getting together with anyone to hit. The ball machine is great for when I suddenly have some spare time to jet over to the local courts at 9pm."
"Here is my Silent Partner Edge Star. I use it twice a week. I love it... If you want an easy wonderful way to practice your ground strokes....this is it. Take 15 minutes to set it and forget it. You are done adjusting forever. Get the remote and larger battery. Put it on the baseline, fill the hopper, walk to the opposite baseline, touch your remote and hit away! It is perfect for this application. You can bang forehands and backhands all day long. Sweep or stay in the same position. It is perfect for this."
"I own a SP Edge with regular battery and use it every week. I set it up and the whole family takes turns hitting and retrieving balls. Really enjoy this machine. It's a big hit on the local court."
"This set-up works extremely well with my SP Star Edge, delivering a consistent deep ball to the corner with loads of topspin. Set the ball feed to chuck another at you as soon as your ball hits the court and you are in for quite a workout. Even with the basic Edge you can work the settings to push a very good player around the court."
"I have the Quest machine so I cannot comment on the additional features of the Smart machine. However I have been completely satisfied with the Quest. In a nut shell it works as advertised. The balls are served consistently and the controls allow for fine tuning of the adjustments. I particularly like the memory features as I have 1 set for warm ups, 2 for narrow sweep medium speed, and 3 for full court oscillation. I've used other machines and this one works better than any other and I would definitely recommend it."
"Silent Partner is famous for its great customer support, and Steve has always answered my questions promptly, so why not check it out directly? Email: sptennis@on.aibn.com phone 1-800-662-1809."


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First virtual endocasts of adapiform primates.
Well-preserved crania of notharctine adapiforms from the Eocene of North America provide the best direct evidence available for inferring neuroanatomy and encephalization in early euprimates (crown primates). Virtual endocasts of the notharctines Notharctus tenebrosus (n = 3) and Smilodectes gracilis (n = 4) from the middle Eocene Bridger formation of Wyoming, and the late Eocene European adapid adapiform Adapis parisiensis (n = 1), were reconstructed from high-resolution X-ray computed tomography (CT) data. While the three species share many neuroanatomical similarities differentiating them from plesiadapiforms (stem primates) and extant euprimates, our sample of N. tenebrosus displays more variation than that of S. gracilis, possibly related to differences in the patterns of cranial sexual dimorphism or within-lineage evolution. Body masses predicted from associated teeth suggest that N. tenebrosus was larger and had a lower encephalization quotient (EQ) than S. gracilis, despite their close relationship and similar inferred ecologies. Meanwhile, body masses predicted from cranial length of the same specimens suggest that the two species were more similar, with overlapping body mass and EQ, although S. gracilis exhibits a range of EQs shifted upwards relative to that of N. tenebrosus. While associated data from other parts of the skeleton are mostly lacking for specimens included in this study, measurements for unassociated postcrania attributed to these species yield body mass and EQ estimates that are also more similar to each other than those based on teeth. Regardless of the body mass prediction method used, results suggest that the average EQ of adapiforms was similar to that of plesiadapiforms, only overlapped the lower quadrant for the range of extant strepsirrhines, and did not overlap with the range of extant haplorhines. However, structural changes evident in these endocasts suggest that early euprimates relied more on vision than olfaction relative to plesiadapiforms, despite having relatively small endocranial volumes compared to extant taxa.
Open Access Copy from Duke
Boyer, Douglas Martin
Harrington, Arianna
Yapuncich, Gabriel
Harrington, AR; Silcox, MT; Yapuncich, GS; Boyer, DM; Bloch, JI
Journal of Human Evolution
10.1016/j.jhevol.2016.06.005
Tomography Scanners, X-Ray Computed


If you are thinking about buying a timeshare in Mexico then there are a few things you should consider first! Obviously it is necessary to do your research before buying, to make sure that you get the very best deal. If you are looking for quality and luxury then Cabo timeshare at Villa del Palmar comes highly recommended.
"We now spend most of our yearly vacations in our Cabo timeshare at Villa del Palmar, though we have visited the Villa del Palmar Flamingos resort in Riviera Nayarit, near Puerto Vallarta, too. We are always impressed by the level of services we receive, the facilities and resort in general!
The benefits of a Cabo timeshare at Villa del Palmar are many, but they are particularly great for those coming from the USA or Canada, as flights tend to be relatively cheap! The most notable benefit, of course, is that a membership gives you access not only to the Cabo San Lucas Villa del Palmar resort, but to the other resorts in Cancun, Riviera Nayarit, Puerto Vallarta and the Islands of Loreto. The flexibility offered, too, is note-worthy. The points based system means that you can stay for longer in more economical suites, or in more luxurious units over a shorter period of time, depending upon your needs.
But what really makes a Cabo timeshare at Villa del Palmar so special are the facilities! The suites are dressed and presented to the highest standard, the resort itself is large and well-kept, and the amenities are comprehensive. On-site there are gourmet restaurants, pools, snack bars, a Spa, a health and fitness centre, and secure access to a wonderful beach! There are also free activities within the resort to keep you and your family entertained.


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MAY2020Emily Casey & Candace Rivela
(Bethel Woods Center for the Arts)sullivan1802020-10-04T16:09:30-04:00
Emily Casey & Candace Rivela (Bethel Woods Center for the Arts)
Sullivan 180 Presents…
TAKE FIVE!
We had the chance to speak with Emily Casey, Director of Marketing, and Candace Rivela, Lead Teaching Artist and Creative Arts Therapist in the Museum Education and Creative Programs Department, at Bethel Woods Center for the Arts to discuss how their programs have changed due to COVID-19, new initiatives like the Growing Hope kits and what Bethel Woods has planned for post-pandemic.
Transcript of Interview with Emily Casey & Candace Rivela
Read transcript...
Meaghan Mullally-Gorr:
Hi, this is Meghan Mullally-Gorr, and this is Sullivan 180 Presents…. Take Five! We are interviewing our friends, partners and community leaders. Today. I have Candice and Emily with me from Bethel woods. Hi guys. How are you? Thanks for joining me. Can each of you introduce yourselves, let us know what you do at Bethel woods?
Candace Rivela:
Sure! My name is Candace Rivela and I am the lead teaching artist and also a creative arts therapist in our Museum Education and Creative Programs department.
Emily Casey:
And I am Emily Casey. I'm the director of marketing for Bethel Woods Center for the Arts.
So a lot has changed recently and as we can see, we're all working from home. Can you guys let us know how your day to day has changed?
Yeah, so it's definitely been interesting, you know, changing all of our meetings into Zooms, but we have kind of shifted a bit of our communications and our programming to try to have an online presence.
Yes. We're trying our best to create online content for the community right now. And I'm kind of reaching across departments on our end and using everybody's brainstorming capabilities and like Emily said, you know, seeing where we can shift our programs online.
Now, have you made that shift? I know that pre COVID-19 you had your art therapy and photography classes all starting to gear up. Has that started yet online?
Yes, actually our "Project Identity" photo class is doing really well. We were able to shift that whole curriculum online, just because of the nature of that program. And it was easily converted into an online forum. I was able to make a couple of videos that shared some art therapy awareness and some at-home projects for self care and things like that, which has been great. I feel like this whole experience of working from home has given us a new outlet to raise awareness about some of the things that we do at Bethel Woods. People may not even know that we have a Creative Arts Therapy Program or, or even know what it is. So that's been one positive thing that's really come out of this whole thing. So is there any programming coming out soon that the community should keep an eye out for? So a lot of it right now is obviously contingent upon the restriction and the stay-at-home. We are looking to do some things utilizing the grounds. You know, we are lucky that our 800 acres do naturally allow for social distancing. So once that is allowed, hopefully we can activate those spaces. We have an outdoor exhibit, 'Earth and Focus', and that's from photographers all over the world to highlight their photos. We did that for Earth Day. And then also we're really excited about our 'augmented reality tour'. It's something we've been working on for about two years now, but basically guests will come and be able to rent a sanitized device and take a tour of the site. It's a walking tour. It will basically put the stage where it was, and it's all told through alumni and music, and it's really fun and exciting. So hopefully when the grounds open, we'll be able to do that.
Is there anything that the community can do to help?
I don't know if there's anything necessarily there for them to help with, but, minimally to stay up on the most exciting and recent news for Bethel Woods, just continuing to kind of check in with what we're doing on social media or on our website or any other outlets where they can stay updated. And just, don't lose hope that we are going to return to our programming eventually, in whatever shape or form that takes. We hope that people will just continue to want to engage with us and we'll do our best to offer things that can continue to inspire and educate everybody.
And that does segue nicely into our 'Growing Hope Program' that we are softly launching currently. We did respond to this with Sullivan Renaissance to launch our 'Growing Hope Program'. So that's planting kits that we are providing to schools to supplement their curriculum. We wanted to do something where it was a creative outlet, but the also kind of a project. So the kits include paint, pots, brushes, directions and seeds. And we're asking them to decorate the pots and then plant the seeds, and watch the progress. And then once this is all over, we're inviting everyone back to the historic grounds where we hope to plant a Peace Garden on the field. We do have a landing page on our website ( www.bethelwoodscenter.org/at home ) that includes information on the Growing Hope Program, but also a slew of other resources, canvases, and creative arts therapy videos are on there. We have some tutorials about painting pots, and some links to our historical archives of Woodstock photos. If people want to go through them, basically that's just become our online resource.
Is there anything else that you guys would like to add before I let you go?
Yes, I want to give a special shout out and acknowledge all of our Bethel Woods teaching artists who are local professional artists and arts educators. And they've just been doing such an amazing job to support us and to provide online content for us. They've been making video tutorials and music lessons at home. Different kinds of ways to engage the community creatively. And so we're just super appreciative of our Bethel Woods teaching artists and all that they're doing to highlight and share what we do a Bethel Woods in such a creative way.
Thank you guys again for joining us. I really appreciate you. Thank you so much.
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www.bethelwoodscenter.org
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Viewings, Felicity's' resurrection and photo's from home!
Apologies for the wait before posts. I can quite honestly say that it is only now that I am beginning to feel human again. We have viewings on Saturday, people are interested! Terry and I had had a moment of transient panic having finished the property, that no-one would be interested. Our fears are momentarily… Read More Viewings, Felicity's' resurrection and photo's from home!


Glass Painting 3d Objects: Easy outlining technique.
Glass Painting on 3d objects such as Vases, round lamps etc. is one of the most difficult techniques. We already have a video on the site which will help you with this but now we'd like to introduce a particular technique which will help you with the outlining, what we call the easy outlining technique. It won't work in every situation but luckily it works best when the outlining is complicated. It doesn't work well when there is little outlining and/or large gaps.
When we've been through it you'll probably say "well that's obvious", as I do now, but I hadn't tried it till a year or so ago. Like with most things it takes a little practice, especially the peeling off the flat surface.
The technique is simple. Rather than outining directly onto the 3d object you outline flat. For the technique to work you need to ensure the outliner you use it peelable, many are including Gallery Glass, "Fun & Fancy" by Marabu and C2 by GalsArt. If you aren't sure then just give yours a test. (strangely I find most outliners which come in bottles are peelable and most which come in tubes aren't).
Next you need to ensure what you pipe onto is both clear (so you can see the design underneath, and something the outliner will come off easily. The answer for me was folder pockets, the clear smooth ones, not the rough semi-opaque ones.
Now you can put your design in or under the pocket and outline it, outlining flat is always easier than on a curved surface. Once outlined you should leave it to dry for at least a day. Once dry VERY carefully peel it off. Don't worry if the odd bit breaks, you WILL be able to reassemble it.
Once off turn it upside down and place it back on the pocket. This is the stage where you should ensure any broken bits are laying in the correct place.
Finally roll the object you want the outline on across the upturned design. It shouldn't matter if the object is cylindrical or spherical, it should work on both.
Peeling and Placing the Design.
Don't worry that the outliner you are using is peelable. The paint will seal it onto the object.
If it doesn't go on "correctly" you should be able to lift bits and correct it.
If there are large gaps in your design you can try adding extra temporary lines to the design then cutting them off with a craft knife once it is on the object.
I hope you enjoy this technique and find it useful. My description is a little complicated but once you have tried it a couple of times I'm certain you will find it an easy outlining technique.
Making and Using Peelable Glass Paint.


text:
Bren, Paulina, author.
The Barbizon : the hotel that set women free / Paulina Bren.
New York, NY : Simon & Schuster, 2021.
vii, 321 pages : illustrations ; 24 cm
"The Barbizon tells the story of New York's most glamorous women-only hotel, and the women-both famous and ordinary-who passed through its doors. World War I had liberated women from home and hearth, setting them on the path to political enfranchisement and gainful employment. Arriving in New York to work in the dazzling new skyscrapers, they did not want to stay in uncomfortable boarding houses; they wanted what men already had-exclusive residential hotels that catered to their needs, with daily maid service, cultural programs, workout rooms, and private dining. The Barbizon would become the most famous residential hotel of them all, welcoming everyone from aspiring actresses, dancers, and fashion models to seamstresses, secretaries, and nurses. The Barbizon's residents read like a who's who: Titanic survivor Molly Brown; actresses Rita Hayworth, Joan Crawford, Grace Kelly, Tippi Hedron, Liza Minelli, Ali McGraw, Jaclyn Smith, and Phylicia Rashad; writers Sylvia Plath, Joan Didion, Diane Johnson, Gael Greene, and Meg Wolitzer; and so many more. But before they were household names, they were among the young women arriving at the Barbizon with a suitcase, and hope. Beautifully written and impeccably researched, The Barbizon weaves together a tale that has, until now, never been told. It is an epic story of women's ambition in the 20th century. The Barbizon Hotel offered its residents a room of their own and air to breathe, unfettered from family obligations and expectations. It gave women a chance to remake themselves however they pleased. No place had existed like it before, or has since"-- Provided by publisher.
Barbizon/63 (New York, N.Y.)
Women -- New York (State) -- Social conditions -- 20th century.
Women -- New York (State) -- Social life and customs -- 20th century.
SOCIAL SCIENCE / Sociology / General.
Women -- Social conditions
Women -- Social life and customs
Informational works.


To join Go Local Food, please fill in the form. When you submit, you will be redirected to our payment partners, GoCardless who will setup your payment in a very simple one page form.
I'd like to take out a subscription for a weekly share of veg. grown by Go Local Food.
We collect payment via Direct Debit. Our partners, GoCardless Ltd, regulated by the financial authority, collect payments on our behalf. You are fully protected under the Direct Debit Guarantee.
In order for the direct debit to be setup, you will need to fill in a very simply one-page form with GoCardless.
Payment amount will depend upon your chosen options. You will be informed of the amount by email from GoCardless prior to your DD collection date.
Membership is renewed annually, crop share and other fees taken monthly.


Finding millipedes in your home? Hire the exterminators at The Pest Detective for comprehensive pest control. We have offices in Vancouver, North Vancouver, Surrey, Victoria, Whistler, and the Tri-Cities area. Learn more about millipedes and how you can identify and prevent them.
Millipedes have a long, cord-like body with a hard outer skin. Their bodies are made up of multiple segments with each segment having a two pairs of legs. Due to their legs being arranged very close together, millipedes move slowly and give a sort of wave-like movement to their bodies. Millipedes are often confused with centipedes; millipedes have two pairs of legs on each body segment while centipedes have one pair per segment.
Millipedes eat decomposing organic matter like leaves and dead wood. They help break down plant matter after microbial decomposition. Millipedes will also eat delicate roots of seedlings or ripening fruit that has fallen to the ground.
You can find millipedes living on the ground outdoors usually in dark places with lots of moisture. Millipedes will usually live close to their source of food like piles of leaf litter or rotting logs. On occasion, they may burrow in moist soil under rocks or in piles of mulch.
Millipedes are considered a minor garden pest that can damage your sprouting seeds or seedlings. They aren't destructive inside the home, but present more of a nuisance and an unwelcome sight to most. Like most arthropods, millipedes die shortly after coming inside, but leave behind their hard exoskeleton intact. Some millipedes release a toxic chemical that can irritate the skin, staining it brown, causing blistering, itching, or burning.
You won't have to take any significant control measures for millipedes as their invasions tend to only include a handful of the insects. To keep millipedes from getting inside, we recommend keeping your residence clean and free of clutter especially the basement or other areas where moisture settles.


Zimbabwean children watch as their mother collects water from a communal tap in Harare, February 5, 2016.
As many as 49 million people in southern Africa could be affected by a drought that has been worsened by the most severe and longest El Nino weather pattern in 35 years, the United Nations World Food Programme (WFP) said on Monday.
The WFP, which has already said 14 million people face hunger in the region, said the El Nino conditions had caused the lowest recorded rainfall between October and December since 1981.


text:
9 crows · 9crows · 9crows blog · Girl Crush of the Week · laragh mcann model · laragh mccann · model · nine crows · nine crows blog · nine crows dublin · nine crows galway · nine crows muse · wcw · woman crush wednesday · woman power wednesday · Aug 16, 2017
Woman Power Wednesday: Laragh McCann
For this week's Woman Power Wednesday, we're looking at the gorgeous Laragh McCann. Laragh is a model who has taken the step into new creative ventures such as directing and photography. Her directorial debut was the incredible My Body, My Choice video for the Repeal campaign, which you can check out here. We caught up with Laragh to chat about the fashion industry, her directing career and her plans for the future. Enjoy!
Photo from models.com
Do you think being in the fashion industry from such a young age had a positive or negative affect on your view of women?
In hindsight, it gave me a great view of woman. The owners of my first agency in Dublin were two sisters. My first shoot was shot by a woman. Aisling Farinella was the main fashion woman in Ireland when I started. The director of my first international agency in Paris, Ford, was a woman. Some of the biggest and most influential names in the fashion industry are women - Miuccia Prada, Anna Wintour, Pat Mcgrath, Simone Rocha, Katie Grand. The girlfriends I made modelling are to this day my role models.
Modelling is also one of the few industries where women are payed a lot more than men. Although, it's quite layered, despite being awestruck by the woman in charge in the industry, these strong woman were really fighting against the tide. Fighting against a big picture that makes woman feel like shit. The fashion industry creates an illusion that beauty is a woman's most powerful asset. That side of things, even though at the time I wasn't fully aware of what I was feeling, really didn't make me feel happy.
The actual industry itself is mainly a business and what sells is making women - the main buyers - feel like they need something so it creates an unhealthy dynamic where women always feel inadequate, especially when comparing to unrealistic standards. Although things are changing so much lately, the trend thankfully is for women (and men) to embrace their bodies and also their minds and their creativity.
Photo from fashiongonerogue.com
What made you want to branch out to photography and directing along with modelling?
I always had that interest. In school I loved art and right from the moment I started modelling I became obsessed with all the photographers and the magazines and pretty much from the get go had a camera with me travelling. Constantly being surrounded by creative people in the industry as well really propelled that instinct further and made a career seem possible, much more tangible then if I'd stayed in college I think.
Photo from laraghmccann.com
My Body, My Choice was your directorial debut, what made you get involved with the project?
Anna Cosgrave of Repeal is one of my best friends. I chatted to her about it when we hung out so I saw the whole campaign come to life from a small idea to what it's become now. Around the same time I was starting out directing, so it was just a natural occurrence with timing and mutual interests aligning.
Photo from fashionmodelsdirectory.com
What else are you working on for the future?
I'm editing a video for Gemma Dunleavy. She has an amazing EP coming out soon. This is a film piece for a song she wrote, half of which is spoken word about hardships growing up in Dublin. We went to where she grew up around Sheriff Street and all her family and neighbours were a part of it so it feels very special. I've written my next short which is in pre production now and I have a spec ad and another music video which are also in pre production.
What women inspire you?
The woman around me day to day inspire me. A lot of people who aren't in the spotlight, literally mothers, doctors, the nice lady in the post office! I feel hugely inspired by Gemma Dunleavy who writes and produces all her work, Stephanie Dufresne who's an amazing dancer who i've worked with a lot lately, Anna Cosgrave, my housemate Beth! I don't think you have to look very far or even on Instagram to see incredible and amazing women.
Follow Laragh on Instagram here
Check out her website here
Ciara x


text:
Bitcoin ABC version 0.19.1 is now available from:

  <https://download.bitcoinabc.org/0.19.1/>

This release includes the following features and fixes:
 - Add `signrawtransactionwithkey` and `signrawtransactionwithwallet` RPCs.
   These are specialized subsets of the `signrawtransaction` RPC.
 - Deprecate `nblocks` parameter in `estimatefee`.  See `bitcoin-cli help estimatefee` for more info. Use `-deprecatedrpc=estimatefee` to temporarily re-enable the old behavior while you migrate.
 - Minor bug fixes and wallet UI cleanup
 - Removed `txconfirmtarget` option from bitcoind

redpajama_set_name: RedPajamaGithub


Crown has been presented with the prestigious IFOY Award in the Forklift Truck Solutions category on Tuesday. Sponsored by the VDMA Materials Handling and Intralogistics Sector Association, the competition's independent jury of internationally respected journalists were impressed by the way Crown's InfoLink® fleet management system streamlined operations at Spicers, one of the UK's largest wholesalers of stationery and office supplies.
The jury was convinced by the efficiency and innovative approach evident in Crown's integrated system solution. By opting for an all-new fleet of Crown lift trucks, complete with the full integration of Crown's InfoLink® system, Spicers has succeeded in reducing fleet maintenance and repair costs by 90 percent. In addition, the fleet management system has enhanced the company's intralogistical efficiency to such an extent that Spicers has cut the size of their lift truck fleet by 40 percent.
In intralogistics, the availability of real-time information on a company's entire fleet of lift trucks and their operators is the key to enhanced productivity. The wireless InfoLink fleet and operator management system processes real-time and historical data to produce itemised, prioritised information. This can be used to make well-grounded decisions that result in significant cost and time savings.
In the course of the one-week IFOY test, held in purpose-built facilities on the Deutsche Messe AG site in Hanover, Crown's customer project was ranked ahead of competing solutions from two of the industry's leading companies in the Forklift Truck Solutions category. This category gives precedence to system solutions that show novelty, innovation, customer benefits, sustainability and marketability.
Sponsored by the German Engineering Federation (Verband Deutscher Maschinen- und Anlagenbau e.V. – VDMA), the purpose of the IFOY Award is to recognise the year's best forklift trucks and forklift truck solutions. The IFOY Awards are among the most prestigious awards made in the intralogistics industry, and are presented annually in partnership with CeMAT. The Award, which is under the patronage of the German Ministry of Economics and Technology, includes three other categories: Warehouse Trucks, Counterbalanced Trucks up to 3.5 tonnes and Counterbalanced Trucks over 3.5 tonnes.


text:
Ringo Starr's Grandson, Liam Gallagher's Son Charged with Assault Following London Brawl
Sonny Starkey and Gene Gallagher are accused of fighting staff at a grocery store
Sonny Starkey and Gene Gallagher, photo via Getty
November 21, 2020 | 3:19pm ET
Ringo Starr's grandson, Sonny Starkey, and Liam Gallagher's son, Gene Gallagher, were in a London court on Friday facing charges of assault stemming from a brawl at a London grocery store last year.
Starkey, Gallagher, and model Noah Ponte are accused of fighting staff at a Tesco Express in North London on May 17th, 2019. Allegedly the confrontation occurred after Ponte attempted to steal beer after the store's curfew for selling alcohol. When an Indian security guard confronted the trio, Ponte allegedly said, "You bloody Indians. Go back to where you came from. You're not wanted here." A physical fight between the trio and grocery story staff then ensued.
According to The Sun, Gallagher and Ponte are accused of racially aggravated assault, while Starkey is facing two charges of assault. Additionally, all three men have been charged with disturbing the peace. They each entered a not guilty plea during their court appearance on Friday.
Ringo Starr's Grandson, Liam Gallagher's Son Charged with Assault Following London Brawl


text:
Blepharis pratensis är en akantusväxtart som beskrevs av Spencer Le Marchant Moore. Blepharis pratensis ingår i släktet Blepharis och familjen akantusväxter. Inga underarter finns listade i Catalogue of Life.

Källor

Akantusväxter
pratensis

redpajama_set_name: RedPajamaWikipedia


text:
McNair died from the effects of heatstroke 15 days after struggling during an outdoor workout. More than an hour elapsed between the time McNair first exhibited symptoms on the field and the time Maryland staff called 911.
The university subsequently sought the advice on its heat-management protocols from physician and athletic training expert Rod Walters, who then outlined mistakes made in Maryland's emergency response. As reported by The Baltimore Sun, the athletic department now ensures that cold water immersion devices are available at all practices, that specific temperature readings are done at each practice location, and that updated emergency plans are posted at all activity sites and drilled into staff, among other implemented recommendations. The two recommendations not yet in place include convening a medicine review board to oversee student-athlete health issues and establishing a model for supervising athletic trainers.
From AB: Report Outlines Mistakes in McNair Tragedy
Evans said the department still is working with sports medicine experts to determine what the best organizational model is for the university's circumstances. "We are looking across the country to see what different models are out there," he said, adding that he hopes members of the athletic medicine review board will be announced soon and meet sometime in May. On Wednesday, the advisory council, chaired by a former university system chancellor, peppered Evans and others with questions about the ways they're learning from McNair's death and appeared pleased with the university's progress.
The council also is overseeing the implementation of recommendations from a separate report that probed the football team's culture. In response to the roughly 200-page report, which concluded that problems festered within the football program because players feared speaking out, the athletic department is prioritizing transparency by encouraging senior officials to drop in on open practices to observe what goes on day-to-day, the Sun reported. The department has also created an online platform, called Terps Feedback, that provides student-athletes the opportunity to submit comments or concerns anonymously.
Evans predicted the bulk of the second report's recommendations would be implemented in the next few months.
Tags: University of Maryland Damon Evans Jordan McNair heatstroke athletic training sports medicine
Maryland Basketball Committed Minor Violations
The NCAA announced minor rules violations committed by both the men's and women's basketball programs at the University of Maryland.
District Athletic Trainer Reflects on 33-Year Career
When Kelly Hoke, fresh out of college in 1986, became the first athletic trainer in the Rome (N.Y.) City School District's history, she had one request: an ice machine. When cell phone technology emerged, she was the first district employee to ask for and receive a brick-like mobile device that allowed Hoke to be reached day and night while tending to student-athletes competing at various venues in grades 7 through 12. But nothing — not education or ice or state-of-the-art connectivity — could equip Hoke for the shock in 2015 of responding to her own son after he was knocked unconscious during an eighth-grade football game. AB senior editor Paul Steinbach asked Hoke, who is retired May 24 from the only professional position she's ever held, about that emotional day and the changes she has witnessed in athletic training over the past 33 years.
U. of Houston Sets Policies in Wake of Rhabdo Cases
The University of Houston is granting its strength and conditioning coaches and sports medicine staff "unchallenged authority" over the safety of athletes in response to a rash rhabdomyolysis cases affecting the athletic department earlier this year.
Maryland Team Physician to Report to Health Center
A national search has been launched to hire a new head team physician for the University of Maryland, with the chosen individual to work under the University Health Center.
Kansas Athletics Shifts Healthcare Oversight to MDs
The University of Kansas athletic department is collaborating with The University of Kansas Health System and LMH Health to launch Kansas Team Health, a new model of student-athlete care believed to be the first of its kind among major collegiate athletics programs, according to the KU athletics website.
District Educates on Head Trauma with New Website
The William S. Hart Union (Calif.) School District board took time to brief parents and community on how coaches are trained, and on a new website called the "Athletic Training Room" that was created in collaboration with a the local Henry Mayo Newhall Hospital.
Study Examines Sudden Deaths in Youth Athletes
New research by the Korey Stringer Institute (KSI) and the University of Connecticut revealed the most common cause of sudden death in American youth sports for athletes aged 6-17 years.


text:
package com.qiniu.storage;

import com.qiniu.common.Config;
import com.qiniu.common.QiniuException;
import com.qiniu.http.Client;
import com.qiniu.http.Response;
import com.qiniu.storage.model.FileInfo;
import com.qiniu.storage.model.FileListing;
import com.qiniu.util.Auth;
import com.qiniu.util.StringMap;
import com.qiniu.util.StringUtils;
import com.qiniu.util.UrlSafeBase64;

import java.util.ArrayList;
import java.util.Iterator;

/**
 * 主要涉及了空间资源管理及批量操作接口的实现,具体的接口规格可以参考
 *
 * @link http://developer.qiniu.com/docs/v6/api/reference/rs/
 */
public final class BucketManager {
    private final Auth auth;
    private final Client client;

    public BucketManager(Auth auth) {
        this.auth = auth;
        client = new Client();
    }

    /**
     * EncodedEntryURI格式
     *
     * @param bucket
     * @param key
     * @return urlsafe_base64_encode(Bucket:Key)
     */
    public static String entry(String bucket, String key) {
        String en = bucket;
        if (key != null) {
            en = bucket + ":" + key;
        }
        return UrlSafeBase64.encodeToString(en);
    }

    /**
     * 获取账号下所有空间名列表
     *
     * @return bucket 列表
     */
    public String[] buckets() throws QiniuException {
        Response r = rsGet("/buckets");
        return r.jsonToObject(String[].class);
    }

    /**
     * 根据前缀获取文件列表的迭代器
     *
     * @param bucket 空间名
     * @param prefix 文件名前缀
     * @return FileInfo迭代器
     */
    public FileListIterator createFileListIterator(String bucket, String prefix) {
        return new FileListIterator(bucket, prefix, 100, null);
    }

    /**
     * 根据前缀获取文件列表的迭代器
     *
     * @param bucket    空间名
     * @param prefix    文件名前缀
     * @param limit     每次迭代的长度限制,最大1000,推荐值 100
     * @param delimiter 指定目录分隔符,列出所有公共前缀(模拟列出目录效果)。缺省值为空字符串
     * @return FileInfo迭代器
     */
    public FileListIterator createFileListIterator(String bucket, String prefix, int limit, String delimiter) {
        return new FileListIterator(bucket, prefix, limit, delimiter);
    }

    /**
     * 根据前缀获取文件列表
     *
     * @param bucket    空间名
     * @param prefix    文件名前缀
     * @param marker    上一次获取文件列表时返回的 marker
     * @param limit     每次迭代的长度限制,最大1000,推荐值 100
     * @param delimiter 指定目录分隔符,列出所有公共前缀(模拟列出目录效果)。缺省值为空字符串
     * @return
     * @throws QiniuException
     */
    public FileListing listFiles(String bucket, String prefix, String marker, int limit, String delimiter)
            throws QiniuException {
        StringMap map = new StringMap().put("bucket", bucket).putNotEmpty("marker", marker)
                .putNotEmpty("prefix", prefix).putNotEmpty("delimiter", delimiter).putWhen("limit", limit, limit > 0);

        String url = Config.RSF_HOST + "/list?" + map.formString();
        Response r = get(url);
        return r.jsonToObject(FileListing.class);
    }

    /**
     * 获取指定空间、文件名的状态
     *
     * @param bucket
     * @param key
     * @return
     * @throws QiniuException
     */
    public FileInfo stat(String bucket, String key) throws QiniuException {
        Response r = rsGet("/stat/" + entry(bucket, key));
        return r.jsonToObject(FileInfo.class);
    }

    /**
     * 删除指定空间、文件名的文件
     *
     * @param bucket
     * @param key
     * @throws QiniuException
     */
    public void delete(String bucket, String key) throws QiniuException {
        rsPost("/delete/" + entry(bucket, key));
    }

    /**
     * 修改指定空间、文件的文件名
     *
     * @param bucket
     * @param oldname
     * @param newname
     * @throws QiniuException
     */
    public void rename(String bucket, String oldname, String newname) throws QiniuException {
        move(bucket, oldname, bucket, newname);
    }

    /**
     * 复制文件。要求空间在同一账号下。
     *
     * @param from_bucket
     * @param from_key
     * @param to_bucket
     * @param to_key
     * @throws QiniuException
     */
    public void copy(String from_bucket, String from_key, String to_bucket, String to_key) throws QiniuException {
        String from = entry(from_bucket, from_key);
        String to = entry(to_bucket, to_key);
        String path = "/copy/" + from + "/" + to;
        rsPost(path);
    }

    /**
     * 移动文件。要求空间在同一账号下。
     *
     * @param from_bucket
     * @param from_key
     * @param to_bucket
     * @param to_key
     * @throws QiniuException
     */
    public void move(String from_bucket, String from_key, String to_bucket, String to_key) throws QiniuException {
        String from = entry(from_bucket, from_key);
        String to = entry(to_bucket, to_key);
        String path = "/move/" + from + "/" + to;
        rsPost(path);
    }

    /**
     * 修改完文件mimeTYpe
     *
     * @param bucket
     * @param key
     * @param mime
     * @throws QiniuException
     */
    public void changeMime(String bucket, String key, String mime) throws QiniuException {
        String resource = entry(bucket, key);
        String encode_mime = UrlSafeBase64.encodeToString(mime);
        String path = "/chgm/" + resource + "/mime/" + encode_mime;
        rsPost(path);
    }

    /**
     * 抓取指定地址的文件,已指定名称保存在指定空间。
     * 要求指定url可访问。
     * 大文件不建议使用此接口抓取。可先下载再上传。
     *
     * @param url
     * @param bucket
     * @param key
     * @throws QiniuException
     */
    public void fetch(String url, String bucket, String key) throws QiniuException {
        String resource = UrlSafeBase64.encodeToString(url);
        String to = entry(bucket, key);
        String path = "/fetch/" + resource + "/to/" + to;
        ioPost(path);
    }

    /**
     * 对于设置了镜像存储的空间,从镜像源站抓取指定名称的资源并存储到该空间中。
     * 如果该空间中已存在该名称的资源,则会将镜像源站的资源覆盖空间中相同名称的资源
     *
     * @param bucket
     * @param key
     * @throws QiniuException
     */
    public void prefetch(String bucket, String key) throws QiniuException {
        String resource = entry(bucket, key);
        String path = "/prefetch/" + resource;
        ioPost(path);
    }

    /**
     * 批量执行文件管理相关操作
     *
     * @param operations
     * @return
     * @throws QiniuException
     * @see Batch
     */
    public Response batch(Batch operations) throws QiniuException {
        return rsPost("/batch", operations.toBody());
    }

    private Response rsPost(String path, byte[] body) throws QiniuException {
        String url = Config.RS_HOST + path;
        return post(url, body);
    }

    private Response rsPost(String path) throws QiniuException {
        return rsPost(path, null);
    }

    private Response rsGet(String path) throws QiniuException {
        String url = Config.RS_HOST + path;
        return get(url);
    }

    private Response ioPost(String path) throws QiniuException {
        String url = Config.IO_HOST + path;
        return post(url, null);
    }

    private Response get(String url) throws QiniuException {
        StringMap headers = auth.authorization(url);
        return client.get(url, headers);
    }

    private Response post(String url, byte[] body) throws QiniuException {
        StringMap headers = auth.authorization(url, body, Client.FormMime);
        return client.post(url, body, headers, Client.FormMime);
    }

    /**
     * 文件管理操作指令
     */
    public static class Batch {
        private ArrayList<String> ops;

        public Batch() {
            this.ops = new ArrayList<String>();
        }

        public Batch copy(String from_bucket, String from_key, String to_bucket, String to_key) {
            String from = entry(from_bucket, from_key);
            String to = entry(to_bucket, to_key);
            ops.add("copy" + "/" + from + "/" + to);
            return this;
        }

        public Batch rename(String from_bucket, String from_key, String to_key) {
            return move(from_bucket, from_key, from_bucket, to_key);
        }

        public Batch move(String from_bucket, String from_key, String to_bucket, String to_key) {
            String from = entry(from_bucket, from_key);
            String to = entry(to_bucket, to_key);
            ops.add("move" + "/" + from + "/" + to);
            return this;
        }

        public Batch delete(String bucket, String... keys) {
            for (String key : keys) {
                ops.add("delete" + "/" + entry(bucket, key));
            }
            return this;
        }

        public Batch stat(String bucket, String... keys) {
            for (String key : keys) {
                ops.add("stat" + "/" + entry(bucket, key));
            }
            return this;
        }

        public byte[] toBody() {
            String body = StringUtils.join(ops, "&op=", "op=");
            return StringUtils.utf8Bytes(body);
        }

        public Batch merge(Batch batch) {
            this.ops.addAll(batch.ops);
            return this;
        }
    }

    /**
     * 获取文件列表迭代器
     */
    public class FileListIterator implements Iterator<FileInfo[]> {
        private String marker = null;
        private String bucket;
        private String delimiter;
        private int limit;
        private String prefix;
        private QiniuException exception = null;

        public FileListIterator(String bucket, String prefix, int limit, String delimiter) {
            if (limit <= 0) {
                throw new IllegalArgumentException("limit must great than 0");
            }
            this.bucket = bucket;
            this.prefix = prefix;
            this.limit = limit;
            this.delimiter = delimiter;
        }

        public QiniuException error() {
            return exception;
        }

        @Override
        public boolean hasNext() {
            return exception == null && !"".equals(marker);
        }

        @Override
        public FileInfo[] next() {
            try {
                FileListing f = listFiles(bucket, prefix, marker, limit, delimiter);
                this.marker = f.marker == null ? "" : f.marker;
                return f.items;
            } catch (QiniuException e) {
                this.exception = e;
                return null;
            }
        }

        @Override
        public void remove() {
            throw new UnsupportedOperationException("remove");
        }
    }
}


text:
Q: When using react-redux's useSelector, an error occurs when setState is called repeatedly in the lifecycle When using react-redux's useSelector, an error occurs when setState is called repeatedly in the lifecycle.
Is this a bug? I want to know the information of people in the same situation.
version:
react: 16.9.0
redux: 4.0.4
react-redux: 7.1.0
const Status = () => {
  const account = useSelector(state => state.account);

  const onClick = (nextLevel: Level) => {
    // cahngeLevel() is fetching,
    // and data is dispatched at the time of resolution.
    changeLevel(nextLevel);
  };

...

}

Invariant Violation: Maximum update depth exceeded. This can happen
  when a component repeatedly calls setState inside componentWillUpdate
  or componentDidUpdate. React limits the number of nested updates to
  prevent infinite loops.

redpajama_set_name: RedPajamaStackExchange


text:
A Minecraft mod that adds Wood polish in the game.

Sit tight, since I haven't started yet.


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text:
U.S. House questions Apple over FaceTime flaw
Mikey Campbell | Feb 05, 2019
Two members of the U.S. House of Representatives called on Apple CEO Tim Cook to answer questions about the company's FaceTime fiasco on Tuesday, saying they were "deeply troubled" by press reports detailing how long it took the company to address what is characterized as a privacy violation.
In a letter addressed to Cook, House Energy and Commerce Chairman Frank Pallone (D-NJ) and Representative Jan Schakowsky (D-IL) inquire about the origins of Apple's Group FaceTime bug and its impact on customer privacy. Pallone and Schakowsky also ask if there are other flaws in the videotelephony product that have not been disclosed to the public.
Citing smartphone usage statistics, with a heavy emphasis on distribution among children, the letter suggests Apple has not been transparent on what Pallone and Schakowsky deem a serious privacy issue. Apple has not been open about its investigation into the FaceTime vulnerability, nor has the company detailed steps being taken to protect consumers, the letter reads.
Last week, reports of a massive FaceTime flaw surfaced on Twitter. Impacting current versions of iOS up to the latest iOS 12.1, the bug enables a FaceTime caller to eavesdrop on another user before they pick up the call. In some cases, brief access to a receiving party's camera is also granted.
Apple disabled Group FaceTime in a server-side shutdown mere hours after the flaw was made public. A fix was promised to arrive last week, but was later delayed for inclusion in a software update this week.
While mainstream media outlets caught wind of the vulnerability last week, Apple was reportedly notified of the issue more than two weeks ago.
Grant Thompson, a 14-year-old from Tucson, Ariz., independently discovered the flaw during a "Fortnite" gaming session in late January. Thompson's mother Michele attempted to inform Apple about the bug over the ensuing week, going so far as to file bug reports with the company. Whether Thompson's reports were lodged through official channels is unknown.
Pallone and Schakowsky in their letter ask Apple to detail the timeline of events leading up to the discovery of the FaceTime flaw, what actions were taken to address the issue, what procedures were in place to safeguard against such vulnerabilities and how they failed, what safeguards are now in place as a result of the discovery and why it took Apple so long to respond to Thompson's bug report. The letter also requests information regarding steps taken to determine whether customer privacy was violated and, if so, whether the company intends to compensate users.
Apple is currently facing a lawsuit from Texas lawyer who claims an interloper leveraged the Group FaceTime bug to eavesdrop on a deposition, while a Montreal law firm filed a class action suit against Apple last week.
The letter from House Democrats arrives days after the announcement of a New York state probe into the matter.
Apple is asked to respond to Pallone and Schakowsky's questions in writing by Feb. 19.
MplsP
Honestly, I get that it's a serious bug, but that's all it is. How is it different from any of the other security flaws in PC's/Macs/Androids/iphones/etc that are discovered on a regular basis? Except for the fact that Apple closed the hole by shutting down the server almost as soon as it was discovered.
AppleZulu
It took a week after the kid's mom notified Apple about the thing for Apple to respond to the issue publicly.
It took a week after Apple responded publicly to the thing for Congress to respond by writing Apple a letter asking why it took them a week to respond.
I'm just saying.
normang
Just a pile of stupid politicians posturing again for something they are totally clueless about. If the people who literally "tripped" over this bug, would have just been patient, everyone these days thinks that things happen instantly and they don't, Apple would have fixed it and it would not have been a big thing, and it really wasn't you had to intentionally add yourself to a multiple person FaceTime conversation, of which you were already in to do this, who does that?? ever....
Uhhhh, many people died from faulty GM ignitions and it took them like a decade to fix it and let's not even talk about the deaths and injuries associated with faulty air bags that are still in millions of cars in the US. A corporation this large cannot! move like some 1000 employee company where everyone drops everything. There are systems in place to ensure that something even worse doesn't occur in haste. Think of it like a false alarm in Hawaii where someone is pressing the launch button because we want to act quickly. Noooooooooooooo!
HeliBum
AppleZulu said:
I would expect Apple to confirm the bug and find the cause before acting on it, which may take a little time.


text:
T20 World Cup | We have played good cricket despite tournament exit, says Virat Kohli as flawed campaign ends for India
India defeated Namibia by nine wickets on Monday in Dubai
| Courtesy - Twitter
After India registered a nine-wicket wicket victory in their final fixture at the Super 12 stage against Namibia on Monday in Dubai, Virat Kohli stated that despite the tournament exit, his team have played quality cricket at the marquee event. He further thanked the outgoing India coaching staff.
After winning the toss, India opted to bowl first, and Jasprit Bumrah started off well for his side as he scalped the wicket Michael van Lingen (14) in the fifth over of the match. Craig Williams (0), who walked out to bat at No.3, could not contribute a single run to the Scotland batting innings and fell to Ravindra Jadeja in the sixth over. The Indian spinners restricted the run flow and scalped wickets at regular intervals to trouble the Gerhard Erasmus-led side. Bumrah scalped two wickets by conceding just 19 runs off his four overs, while Ravichandran Ashwin and Jadeja clinched three wickets each to restrict Namibia to 132/8.
In reply to Namibia's 132, openers Rohit Sharma (56) and KL Rahul partnered for an 86-run stand, and placed India in a dominating position before the former departed in the 10th over. Rahul scored an unbeaten 54 off 36 balls, and stitched up a 50-run stand along with Suryakumar Yadav (25*) to guide India to their third successive victory at the Super 12 stage. Notably, Rohit Sharma became the third cricketer to score 3000 runs in men's T20I cricket. Despite three straight wins at the group stage, India are knocked out of the tournament as they are placed third on the points table behind Pakistan and New Zealand.
Reflecting on India's T20 World Cup 2021 campaign, Virat Kohli stated that despite two successive defeats at the Super 12 stage, the team made a strong comeback in the tournament. He further added that it has been a honour to lead Team India in the shortest format.
"Relief firstly (on leaving T20I captaincy). It's been a honor but things need to be kept at the right perspective. I felt this was the right time to manage my workload. It's been six or seven years of heavy workload and there is a lot of pressure. The guys have been fantastic, I know we haven't got the results here but we have played some really good cricket. The guys have really made my work easier. The way we played the last three games, it's a game of margins - T20 cricket these days. Two overs of attacking cricket at the top is what we were missing in the first two games. As I said, we weren't brave enough in those games and in the group we were in, it was tough," said Kohli after the match.
Kohli thanked the outgoing coach staff, and reckoned that the Ravi Shastri-led team created a wonderful environment for the players in the team. Kohli further added that he would like to contribute more to Indian cricket as a player in the upcoming years.
"A big thank you to all those guys (Ravi Shastri and his support staff). They have done a great job over the years, creating such a wonderful environment for the players. People loved to get back to the atmosphere. They have done a really great job. That (his aggression) is never going to change. The day it does, I'll stop playing cricket. Even before I became captain, I have always loved to contribute in some way or the other. Surya didn't get much gametime in this World Cup, so I thought it will be a nice memory to take back. That was the idea (behind not batting himself," he added.
Ravindra Jadeja, who was adjudged Man of the Match for his stellar performance with the ball, stated that he enjoyed bowling against Scotland batsmen in Dubai. Reflecting on Virat Kohli's stint as India T20I captain, Jadeja stated the outgoing captain has been a great leader in white-ball cricket.
"As a bowler, I did enjoy bowling today. The ball was dry so I enjoyed bowling with a dry ball. Some balls were turning, some were going straight, so that's also a trick, the batsman has to keep on guessing. (on Ashwin) I'm enjoying bowling with him, I've been playing with him since 10 years. He's doing wonderfully with the white ball, did it in IPL also. Virat has been wonderful with the captaincy, and I've played with him for 10-12 years too. I always enjoyed his captaincy. He's positive and aggressive that's what you want as a player. (On the departing support staff) They have done a great job as supporting staff for 7-8 years and we've enjoyed being with them," said Jadeja after the match.
Incidentally, Virat Kohli played his 50th match as India's T20I captain, and he led the Men in Blue to victory in 29 games, with 16 ending in a defeat.
Not the ideal World Cup for us, but we learn and grow. Grateful to all our fans for the love and support. Thank you to our coaches for helping us grow as cricketers. A big shout-out to @virat.kohli for being a leader who led by example and for everything you have done for us. 🇮🇳🙏
View attached media content
- KL Rahul (@rahulkl) 10 Nov 2021
T 20 World Cup 2021
Namibia Cricket Team


text:
Michelle Obama Pays Tribute To Cameron Boyce After His Death: He Had An 'Incredible Heart'
July 9, 2019 10:00PM EDT
'RHOBH' Season Finale: Lisa Vanderpump Claps Back At Kyle For Calling Her 'A Liar'
Nicole Weingart/Bravo
Deputy Editor of Los Angeles
During the July 9 season finale of 'RHOBH', Kyle revealed that she ran into Lisa Vanderpump in Neiman Marcus and LVP didn't seem too happy to see her.
After Camille Grammer's heated fight with the ladies at an event for Mauricio Umansky's company, The Agency, the July 9 season finale of The Real Housewives of Beverly Hills jumped forward six months to May 2019, when the cast met up at Kyle Richards' house to talk about their recent, and very awkward, run-ins with Lisa Vanderpump. First up was Lisa Rinna, who revealed that she ran into LVP in "the parking garage on Bedford".
She further explained, "I was waiting for my car, and I heard this: 'Oh, God.' I just didn't say anything. Like I just sat there and looked at her. So, she goes to get her car, and she's fumbling in her purse for money. And her nails are wet. So she's like fumbling, and all of a sudden, I turn around and I go, 'Do you need some money?' She goes, 'No! And if I did, I wouldn't take yours.' And that was it."
Then, in a private confessional, Lisa Rinna added, "I was still willing to lend her a few bucks after all the bulls***. I was. [It was] so good", before she started laughing uncontrollably.
As for Kyle — her run-in with Lisa Vanderpump wasn't as snarky. Instead, it was quite heartbreaking. Kyle explained, "I also ran into Lisa Vanderpump at Neiman Marcus. I said, 'Hi, Lisa'. And she went like, 'Hello.'" But, "She was really shocked." Kyle then went on to explain that she asked how Lisa was doing before saying she was "'sorry about how everything has turned out, and everything that's happened between us. I really don't think it needed to be this way at all.' And she said, 'Well, you called me a liar!' And I said, 'No. I didn't call you a liar. Those are your words.' I feel sad just because I realize nothing's going to change. While I have great empathy for what she's gone through, I do, it also doesn't excuse behavior. And you know, this is not behavior because she's going through a hard time — it's stuff that she's already been doing, you know, since I've known her."
Then, all the ladies acknowledged that they're "all capable of saying sorry" — everyone except for Lisa Vanderpump. So they're happy with the way things have turned out, but it's no one's fault except for LVP's.
As for whether or not the show can survive without LVP, given the fact that she quit before the ladies filmed the reunion — well, only time will tell. But for now, tune into the three-part RHOBH Season 9 reunion, which kicks off next Tuesday, July 16 at 9pm on Bravo!
The Real Housewives Of Beverly Hills
More 'RHOBH' News:
'RHOBH' Reunion Trailer: Kyle Richards Cries Over Losing Her Friendship With Lisa Vanderpump
'RHOBH' Finale: Camille Lashes Out At Teddi During Heated Fight With Kyle -- 'You're Not Worth My Time'
Lisa Vanderpump Feels 'Conflicted' Ahead Of 'RHOBH' Finale: 'It's An End Of An Era'
Oscars 2020: Best Live Action Short Film Predictions


Under their proposal, illegal immigrants would get three-year visas that could be renewed once. After completing six years of work, the immigrants would be eligible to "get in the back of the line" to apply for permanent legal residency, McCain said.
You are in violation of American law. Here's your fine. Welcome to America.
This has got to be one of the more idiotic immigration proposals I have seen. Once you give an illegal immigrant a visa, he/she is no longer illegal. It's amnesty with a stupid fine.
Well, if you are able to give them a fine, they must be in some sort of federal custody. Thus, they could be deported. Throwing out a number like '10 million to 12 million illegal immigrants' is dishonest, since we are only talking about the ones that have been caught. I can almost forgive Ted Kennedy since he is from Massachusetts, and after all, he is Ted Kennedy. But a Republican from Arizona ought to know better.
Hold on to your sombreros: Below is an immigration position I can agree with.
"I am, you know, adamantly against illegal immigrants."
Immigration is the one issue that can potentially split the Republicans. These guys had better get it together come election time.


text:
Chromosomal Microarray (CMA)
Trio Exome Analysis
Polygenic Risk Score for Coronary Artery Disease
What is Cardiogenetics?
Heart disorders are passed on through generations, affecting people at any age and can be life-threatening. These heart disorders are genetically heterogeneous and have variable clinical presentations. Pathogenic variant(s) in a single gene may be associated with different cardiac conditions (clinical heterogeneity). In different genes, it may cause a similar cardiac phenotype (genetic heterogeneity). The phenotypes can be inherited in an autosomal dominant, autosomal recessive, or X-linked manner, depending on the specific etiology. Cardiomyopathies can also be inherited in a mitochondrial manner. There is a strong genetic component in many commonly seen cardiac ailments.
The estimated prevalence of cardiovascular diseases in India is about 10.5% of the population, which is approximately 32 million affected individuals1
11% of non-diabetic patients and 21.4% of diabetic patients are at risk of being diagnosed with cardiovascular diseases1,2,3 & 4
The incidence of cardiac diseases has increased from 2% to 10.5% of the urban population1
Congenital Heart Disease has an estimated prevalence of 2 to 6 per 1000 live births
Familial Hypercholesterolemia affects about 1 in 500 people in most countries
[1] Jayashree S., Arindam M. and Vijay K. V. 2015 Genetic epidemiology of coronary artery disease: an Asian Indian perspective. J. Genet. 94, 539–549
[2] Mohan V, Deepa R, Rani SS, et al. Prevalence of coronary artery disease and its relationship to lipids in a selected population in South India: The Chennai Urban Population Study (CUPS No. 5). J Am Coll Cardiol 2001;38:682-7. 10.1016/S0735-1097(01)01415-2
[3] Gupta, Rajeev. "Recent trends in coronary heart disease epidemiology in India." Indian heart journal 60.2 Suppl B (2008): B4-18.
[4] Enas, Enas A., and A. Senthilkumar. "Coronary Artery Disease in Asian Indians: An Update and Review." (2001).
Book Test Now
What are the common cardiac diseases that have a genetic component?
Congenital Heart Disease (CHD)
Congenital Heart Disease is the most common type of birth defect, representing an important cause of infant morbidity and mortality
CHD refers to structural and functional heart defects present during birth, that include septal defects, valve defects, and outflow tract anomalies
Syndromic CHD can be due aneuploidies, chromosomal deletions or translocations, or single-gene defects
Cardiac Channelopathies
Cardiac Channelopathies develop as a result of mutations in genes encoding ion channel proteins, involved in cardiac conduction thereby impairing channel function
Most channelopathies follow an autosomal dominant pattern of inheritance
Long QT Syndrome (LQTS)
Long QT Syndrome is the most common cardiac channelopathy, estimated to affect about 1 in 2500 persons It can be asymptomatic or characterized by symptoms like arrhythmias/heart flutters, syncope/fainting, and sudden cardiac death
Currently, there are 13 types of LQTS depending on the presence of the mutation along with the various genes
Majority of LQTS follow the autosomal dominant mode of inheritance
Short QT Syndrome (SQTS)
Short QT Syndrome is inheritable cardiac channelopathy characterized by abnormally short QT intervals and atrial fibrillation in the absence of structural heart disease
A cardiac arrest is the most frequent symptom (up to 40%), followed by palpitations (30%), syncope (25%), and Atrial Fibrillation (AF)
Brugada Syndrome (BS)
Brugada Syndrome is characterized by ST-segment elevation in leads V1–V3 of an electrocardiogram (ECG)
Sudden cardiac death could be the first manifestation of the disease
BS can occur from early infancy to late adulthood
Affected individuals develop monomorphic ventricular tachycardia; often precipitated during sleep or rest, and especially fever
BS accounts for 4% to 12% of sudden cardiac deaths
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
Catecholaminergic Polymorphic Ventricular Tachycardia is a pathological condition whereby intense physical exercise or acute emotional stress can trigger ventricular tachycardia (abnormal heartbeat) which can lead to dizziness, fainting (syncope) and in the worst cases, cardiac arrest and sudden death
CPVT affected individuals have normal resting EKGs with a structurally and functionally normal heart
CPVT has an estimated prevalence of 1 in 10,000 people and commonly manifests at an early age
Cardiomyopathy is a disease of the heart muscle, characterized by an enlarged, thick, or rigid muscle
Cardiomyopathy can lead to heart failure, arrhythmias, and/or sudden death
It can also be a symptom of other genetic diseases such as Noonan's syndrome, Danon disease, Fabry disease, mitochondrial myopathy, or muscular dystrophy
Hypertrophic Cardiomyopathy is also known as Idiopathic Hypertrophic Subaortic Stenosis (IHSS)
HCM is characterized by thickening of the left ventricle thereby restricting blood flow through the heart, and for the left ventricle to fully relax
Children with HCM are also at increased risk for arrhythmia
Dilated Cardiomyopathy (DCM)
Dilated Cardiomyopathy, also known as congestive cardiomyopathy, is a common form of cardiomyopathy in children, and ischemic cardiomyopathy is the most common type of dilated cardiomyopathy
In DCM, the heart becomes enlarged and does not contract, or squeezes poorly
Restrictive Cardiomyopathy (RCM)
In Restrictive Cardiomyopathy, the ventricle cannot relax properly. As a result, blood flows back into the atria, and they become enlarged, while the ventricles remain normal in size
This is a rare form of cardiomyopathy that can occur anytime from childhood to adulthood
Arrhythmogenic Right Ventricular Dysplasia (ARVD)
Arrhythmogenic Right Ventricular Dysplasia is a disorder of the muscular wall of the heart where part of the myocardium breaks down over time, increasing the risk of an abnormal heartbeat (arrhythmia) and sudden death
It usually appears after 10 years of age
Left Ventricular Non-compaction (LVNC)
Left Ventricular Non-compaction is the most recently classified form of cardiomyopathy, characterized by abnormal trabeculations in the left ventricle, most frequently at the apex
It can be associated with left ventricular dilation, systolic or diastolic dysfunction, or both, or various forms of congenital heart disease
It is a condition where the muscular wall of the left ventricle appears 'spongy'
It can affect the heart's ability to work efficiently as a pump and affect the electrical signaling of the heart
Familial Hypercholesterolemia (FH)
Familial Hypercholesterolemia is a genetic condition of the abnormally high level of cholesterol in the blood
Deposition of cholesterol in the walls of arteries leads to atherosclerosis resulting in coronary artery disease and heart attack
FH can be transmitted in both autosomal dominant and recessive inheritance patterns
Inherited forms of hypercholesterolemia resulting from mutations in the LDLR, APOB, or PCSK9 gene have an autosomal dominant pattern
The mutations in the LDLRAP1 gene cause an autosomal recessive form
Why do you need genetic testing for cardiac diseases?
A genetic diagnosis can be life-saving as genetic test results can direct and improve patient treatment, management, and target surveillance for cardiovascular complications
They can help determine if an individual carries a disease-causing variant associated with a heritable risk to develop cardiomyopathy
This provides valuable information to the patient and their family about future medical management
Genetic testing can differentiate hereditary cardiomyopathy/channelopathy from other genetic and non-genetic heart conditions
Cardiovascular Pharmacogenomics
Pharmacogenetics involves applying DNA sequence data to predict drug response, and also to drug discovery and development
It helps prescribe the right drug and dosage to the patient
Significant interpatient variability in drug response can be attributed to genetics
A person's genotype can influence drug metabolism, drug transport, and sensitivity to a drug
Sufficient guidelines describing the use of genetic information are now available to guide treatment with these therapies
When do you need to get tested?
Patients with heart defects present since birth
Unexplained cardiac arrest or sudden deaths in the family that might have been caused by an undiagnosed heart disease
Heart failure at less than 60 years of age
Early heart attack, coronary artery disease, or stroke
Enlarged aorta or aortic aneurysm in the chest at less than 55 years of age
Sudden infant death syndrome (SIDS) in the family
High cholesterol level
Who needs to get tested?
Individuals presenting with symptoms of cardiovascular disease
Individuals with a family history of CAD or familial hypercholesterolemia or other cardiovascular diseases
Individuals with high lifestyle risk i.e. with hypertension, diabetes, smoking habits, alcohol consumption, stressful lifestyle, etc
All individuals above the age of 35 years, with comorbidities like hypertension, diabetes, or elevated blood cholesterols
Why recommend Actia for patients with Cardio Genetics?
Actia offers a broad range of pre-designed gene mutation panels which have been developed with in-depth disease understanding of the genetic disorder incorporating the latest research in that particular domain. New updated technologies, helpful customer service, and clear result interpretation along with counselling sessions with our expert genetic counsellors make us equipped to provide you with the best available support for your patients and families with cardiovascular disease
Actia offers
Actia Cardiac Channelopathy Panel: Includes sequence analysis of 50 genes that encode myocardial ion channels that regulate cation in influx/efflux, as well as channel-associated regulatory factors and interaction partners.
Actia Cardiomyopathy Panel: Includes sequence analysis of 154 genes associated with cardiomyopathy that often encode proteins of the sarcomere
Cardiomyopathy Predisposition Test: An additional testing option available where a 25bp deletion in the MYBPC3 gene is looked into
Hypercholesterolemia Gene Panel: NGS panel with 23 genes associated with FH
Clopidogrel dosage CYP2C19*2 & CYP2C19*3
Statin-induced myopathy predisposition SLCO1B1 p.(Val174Ala) by RT-PCR
Warfarin dosage-VKORC1 (c.-1639 G>A), CYP2C9*2, CYP2C9*3, CYP2C9*13 by RT-PCR
What are the test methodologies?
Next-generation Sequencing (NGS) Using genomic DNA extracted from blood, the coding regions of all the genes are captured and sequenced simultaneously by NGS technology on an Illumina platform. The sequence data that is generated is aligned and analyzed for sequence variants.
Multiplex Ligation-dependent Probe Amplification (MLPA) Deletion and duplication analysis of genomic DNA is carried out by MLPA. This method allows for the amplification of multiple targets with only a single primer pair.
Test sample requirements
Blood (3-5ml in EDTA tubes)
Relevant clinical information including all the clinical presentations and symptoms
Turn around time (TAT)
28 days for NGS
15 days for MLPA
Extracted DNA samples (1µg high-quality DNA)
FREE GENETIC COUNSELLING
Actia offers all your patients FREE pre & post-test genetic counselling with our expert and certified genetic counsellors. We offer the best available support for your patients and families via
Helpful customer service
Clear result interpretation
Counselling sessions with our genetic counsellors
Spina bifida is part of a group of birth defects called neural tube defects.
Genetic testing provides hope for couple with family history of hearing loss
Free Genetic Counseling by MedGenome Genetic Experts
Please share your details with our genetic experts to answer your queries
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