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Because Heifer is But Did You Die Heifer Shirt, focused, and smart organization that does things right and respectfully to the recipients of the animals – both the individual family and their villages.
Peta And that the goats you're using But Did You Die Heifer Shirt are being abused, I think it would be beneficial for heifer international to investigate these allegations and see the meaning of them – of course we'd prefer a vegetarian approach.
I am hearing disturbing reports of But Did You Die Heifer Shirt you are giving away being wounded and even sometimes having violent deaths. While I believe you run an ethical organization that tries to do the right thing for the all the people and animals concerned. I would really appreciate you looking into this. Thank you for your consideration in this matter. Best Always.


text:
Q: How to solve "Using Hibernate built-in connection pool (not for production use!)" using JPA i.e. Hibernate EntityManager I'm new to Hibernate and JPA in general.
I read a lot about this warning, but I still can't solve it.
The answers I read so far, said that it is necessary to have hibernate.cfg.xml in the project.
But I also read that:

If you are using JPA i.e. Hibernate EntityManager, you'll need the persistence.xml. So you generally don't need both as you use either Hibernate proprietary API or JPA.
  (what is the purpose of two config files for Hibernate?)

Using persistence.xml I have this warning every time I use Hibernate.
This is my persistence.xml:
<persistence version="2.0"
    xmlns="http://java.sun.com/xml/ns/persistence"
    xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
    xsi:schemaLocation="http://java.sun.com/xml/ns/persistence
http://java.sun.com/xml/ns/persistence/persistence_2_0.xsd">

    <persistence-unit name="integration"
        transaction-type="RESOURCE_LOCAL">
        <provider>org.hibernate.jpa.HibernatePersistenceProvider</provider>

        <properties>
            <property name="hibernate.dialect"
                value="org.hibernate.dialect.MySQL5InnoDBDialect" />
            <property name="hibernate.hbm2ddl.auto" value="update" />
            <property name="hibernate.connection.url" value="jdbc:mysql://localhost:3306/db-name?autoReconnect=true"/>
            <property name="hibernate.connection.username" value="root" />
            <property name="hibernate.connection.password" value="root" />
            <property name="hibernate.show_sql" value="false" />
            <property name="hibernate.format_sql" value="true" />
            <property name="hibernate.id.new_generator_mappings"
                value="true" />
        </properties>
    </persistence-unit>

</persistence>

I can't figure out what I'm doing wrong.
Thanks in advances

A: It is just a warning stating that you are using a built_in connection pool which is not a suitable solution in the production environment, you should use the application server connection pool in the production environment. depending on your application server you can setup database connection inside your application server then configure hibernate to use that connection.
But if you want to solve this problem without configuring the application server you can see this.

redpajama_set_name: RedPajamaStackExchange


text:
Group at State House supports bill to take guns from domestic abusers
Jacqueline Tempera Journal Staff Writer jacktemp
PROVIDENCE, R.I. — Sharing personal stories of domestic and gun violence more than 70 people gathered in the State House rotunda Tuesday to show support for the "Protect Rhode Island Families Act."
The proposed legislation from the House and Senate would require those convicted of a domestic-violence crime to surrender any firearms they have and prevent them from purchasing more.
Providence Police Chief Colonel Hugh T. Clements spoke in support of the legislation, which he says is a "no-brainer."
"In Providence we have a gun problem," Clements said. He said that, from 2006 to 2015, 54 people died because of a domestic-violence incident. Most of these people were killed with a gun.
"It's going to happen this year," Clements added, and received applause from the crowd.
The Rhode Island Coalition Against Domestic Violence and Sisters Overcoming Abusive Relationships support the measures.

redpajama_set_name: RedPajamaCommonCrawl


text:
De Presidential Medal of Merit (Pampanguluhang Medalya ng Merito) is een Filipijnse onderscheiding. De onderscheiding werd in 2003 door Executive Order nr. 236 hernoemd van Presidential Merit Award in Presidential Medal of Merit.

Voorwaarden voor toekenning
De Presidential Medal of Merit kan worden toegekend aan Filipino's en buitenlanders als iemand:
 uitmuntende diensten heeft geleverd aan de Filipijnse president, de regering of leden van het kabinet;
 prestige voor de Filipijnen heeft verworven bij een internationaal evenement, op gebieden als literatuur, wetenschap, kunst, milieu;
 zich als cultuurmedewerker of kunstenaar in een adviseursfunctie verdienstelijk heeft gemaakt in overheidsdienst of als buitenlandse kunstenaar zich heeft ingezet ten behoeve van de Filipijnse cultuur;
 het prestige van de Filipijnen heeft vergroot als hoofd van een Filipijnse delegatie of een bijdrage heeft geleverd aan het succes van een belangrijk internationale conferentie of evenement die zorgen voor prestige en eer voor de Filipijnen, waaronder presidentiële bezoeken aan het buitenland en belangrijke internationale evenementen in de Filipijnen.

Ontvangers
Enkele met de Presidential Medal of Merit onderscheiden personen:
 Federico Aguilar Alcuaz (2007)
 Zeneida Amador (2005)
 apl.de.ap (2006)
 George Canseco (2005)
 Jovita Fuentes (1958)
 Narcisa de Leon (1960)
 Leonor Orosa-Goquingco (1970)
 Francis Magalona (2009)
 Anita Magsaysay-Ho (2006)
 Juan Nakpil (1955)
 Paeng Nepomuceno (1984)
 Carlos Romulo (1949)
 Sixto Roxas (1969)
 Nena Saguil (2006)
 Juvenal Sanso (2006)
 Romeo Tabuena (2006)
 will.i.am (2006)
 Oscar Yatco (2006)
 Leland Yee (2010)
 Oscar de Zalameda (2006)
 Fernando Zobel de Ayala (2006)

Externe link
 Executive Order no. 236, http://www.gov.ph (geraadpleegd op 2 maart 2013)

Onderscheiding in de Filipijnen

redpajama_set_name: RedPajamaWikipedia


text:
package de.craftolution.craftoplugin;

import de.craftolution.craftoplugin.service.command.exception.ParseDurationException;
import de.craftolution.craftoplugin.service.command.utils.DurationParser;
import org.junit.Test;

import java.time.Duration;

import static org.junit.Assert.assertEquals;

public class DurationParserTest {

	@Test
	public void test1() throws ParseDurationException {
		assertEquals(Duration.ofHours(4), DurationParser.parse("4h"));

		Duration dur = Duration.ofDays(14);
		assertEquals(dur, DurationParser.parse("2w"));

		dur = dur.plus(Duration.ofDays(3));
		assertEquals(dur, DurationParser.parse("2w3d"));

		dur = dur.plus(Duration.ofHours(20));
		assertEquals(dur, DurationParser.parse("2w3d20h"));

		dur = dur.plus(Duration.ofMinutes(7));
		assertEquals(dur, DurationParser.parse("2w3d20h7m"));

		dur = dur.plus(Duration.ofSeconds(10));
		assertEquals(dur, DurationParser.parse("2w3d20h7m10s"));
	}

	@Test
	public void test2() throws ParseDurationException {
		Duration dur = Duration.ofDays(Integer.MAX_VALUE)
			.plus(Duration.ofHours(Integer.MAX_VALUE))
			.plus(Duration.ofMinutes(Integer.MAX_VALUE))
			.plus(Duration.ofSeconds(Integer.MAX_VALUE));

		System.out.println(dur);

		StringBuilder input = new StringBuilder()
			.append(Integer.MAX_VALUE).append("d")
			.append(Integer.MAX_VALUE).append("h")
			.append(Integer.MAX_VALUE).append("m")
			.append(Integer.MAX_VALUE).append("s");

		assertEquals(dur, DurationParser.parse(input.toString()));
	}

	@Test
	public void test3() throws ParseDurationException {
		assertEquals(Duration.ofDays(5), DurationParser.parse("5d"));
		assertEquals(Duration.ofHours(5), DurationParser.parse("5h"));
		assertEquals(Duration.ofMinutes(5), DurationParser.parse("5m"));
		assertEquals(Duration.ofSeconds(5), DurationParser.parse("5s"));
	}

	@Test
	public void testZero() throws ParseDurationException {
		assertEquals(Duration.ZERO, DurationParser.parse("0w"));
		assertEquals(Duration.ZERO, DurationParser.parse("0d"));
		assertEquals(Duration.ZERO, DurationParser.parse("0h"));
		assertEquals(Duration.ZERO, DurationParser.parse("0m"));
		assertEquals(Duration.ZERO, DurationParser.parse("0s"));
	}

	@Test(expected = ParseDurationException.class)
	public void testInvalid1() throws ParseDurationException {
		DurationParser.parse("hello");
	}

	@Test(expected = IllegalArgumentException.class)
	public void testInvalid2() throws ParseDurationException {
		DurationParser.parse("");
	}

	@Test(expected = ParseDurationException.class)
	public void testInvalid3() throws ParseDurationException {
		DurationParser.parse("d");
	}

	@Test(expected = ParseDurationException.class)
	public void testInvalid4() throws ParseDurationException {
		DurationParser.parse("3453");
	}

	@Test(expected = ParseDurationException.class)
	public void testNegative() throws ParseDurationException {
		System.out.println(DurationParser.parse("5d-3m10s"));
	}

}

redpajama_set_name: RedPajamaGithub


The exhibition is curated by Dr. Christopher Webster van Tonder, Senior Lecturer in Fine Art and Curator of Photography here at the School of Art. It includes a great selection of images from our own museum collection of vintage photographs as well as several new darkroom prints that Dr. Webster made from our collection of negatives of Hans Saebens and Erich Retzlaff. In addition, the exhibition shows 14 digital copies of the work of Hans Retzlaff from the Ludwig-Uhland-Institut für Empirische Kulturwissenschaft, at the University of Tübingen.
The Molesworth is delighted to present Helen Blake's second solo exhibition at the gallery. Blake is a painter whose practice focuses on colour, engaging with rhythm and formalism, chance and deliberation. Using a working method where process and contemplation guide the evolution of the work, her small, overtly hand-made paintings record and examine colour conversations within accumulating pattern structures, embracing accidents, flaws and discrepancies within their rhythms.
Andrew Wilson, Curator of Modern and Contemporary British Art at Tate Britain, has written of Blake's work that is underpinned by process – "always variously methodical and rational, yet also absurd and affected by the interruption of chance. In Blake's paintings, colour is deployed to follow a given order and yet these are paintings of nature ….. not the rigid order of an urban modernism, but the texture and rhythms, and immediacy of life unfolding".
School of Art postgraduates Carmel Reid and Angharad Taris have been chosen to show a selection of their works at Mall Galleries, London. Below you find the press release of Mall Galleries, which is a short introduction to Angharad, her work and the exhibition in general, and a few of her paintings, and Carmel's artist's statement and some of her works.


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Whether you're cruising down the street on a hoverboard or experiencing a whole new reality with our Vizor glasses, you're sure to set a trend for the future!


text:
Home›Features›Scientists cure HIV-positive man in London
FeaturesTechnology
Scientists cure HIV-positive man in London
A stem-cell treatment put a London cancer patient's HIV into remission, marking the second such reported case and reinvigorating efforts to cure the AIDS-causing infection that afflicts some 37 million people globally.
The patient has been in remission for 19 months, the International AIDS Society said in a statement. That's too soon to label the treatment — which used hematopoietic stem cells from a donor with an HIV-resistance gene — as a cure, researchers said Tuesday in a study in the journal Nature. Hematopoietic stem cells give rise to other blood cells.
An embargo on the paper was lifted due to early reporting of the finding. The New York Times said Monday that the latest surprise success confirms that a cure for HIV infection is possible. University College London researchers made the announcement at the annual Conference on Retroviruses and Opportunistic Infections in Seattle this week.
Acute myeloid leukemia patient Timothy Brown, who became known as the "Berlin patient," was treated aggressively more than a decade ago in an HIV-curing approach that hasn't been successfully repeated until Ravindra Gupta and colleagues showed the effectiveness of a less aggressive form of treatment.
Gupta's case was in an HIV-positive man with advanced Hodgkin's lymphoma who received a transplant of hematopoietic stem cells from a donor with two copies of the so-called CCR5 gene mutation — the same one allegedly edited by He Jiankui that led to the birth of the world's first gene-edited babies last year.
"Coming 10 years after the successful report of the 'Berlin Patient,' this new case confirms that bone marrow transplantation from a CCR5-negative donor can eliminate residual virus and stop any traces of virus from rebounding," said Sharon Lewin, director of the Peter Doherty Institute for Infection and Immunity at the University of Melbourne, in a statement.
"The so-called London Patient has now been off ART for 19 months with no viral rebound which is impressive, but I would still be closely monitoring his viral load," said Lewin, who is also co-chair of the International AIDS Society's Towards an HIV Cure initiative.
'Scalable Approach'
The London patient has no detectable HIV virus, Gupta and colleagues said. "We speculate that CCR5 gene therapy strategies using stem cells could conceivably be a scalable approach to remission," they said.
Scientists at IciStem, a consortium of European scientists researching use of stem cell transplants to treat the illness, say the London patient received a bone-marrow transplant in 2016 and was given immunosuppresive drugs. He stopped taking his HIV medication in September 2017.
"This is the second reported case of prolonged remission off antiretroviral therapy post bone-marrow transplantation from a CCR5-negative donor," International AIDS Society President Anton Pozniak said in the statement. "Although it is not a viable large-scale strategy for a cure, it does represent a critical moment in the search for an HIV cure."
There are important limitations to applying the findings of the London patient to a HIV cure, said Anthony Kelleher, director of the Kirby Institute at the University of New South Wales in Sydney. Still, the London case shows that "HIV cures are possible," he said.
"Common to both approaches is the presence of a modified gene in our immune system — CCR5 — that is necessary for HIV infection," Kelleher said in a statement. "This tells us that the feasibility, and importantly, the availability of delivering this approach could possibly be achieved by the rapidly accelerating field of gene editing and related gene therapies."
Since the beginning of the AIDS epidemic, more than 70 million people have been infected with HIV and about 35 million people have died because of complications from the viral illness. Worldwide, an estimated 36.9 million people were living with HIV at the end of 2017.
Progress against AIDS over the past 15 years has inspired a commitment by United Nations member states to end the epidemic by 2030. The number of people newly infected with HIV fell to 1.8 million worldwide in 2017, from more than 3 million a year through most of the 1990s.
TagsHIVlondonscientists
I made money from men sleeping with my ex-girlfriend: Shatta Wale
Your parents should be your role models not strangers"- Yvonne Jegede
Doctors protest against salary increase in Canada
2.4 million individuals visit porn website per hour
PDP rejects sack of Babachir, Oke, pushes for full prosecution
Nigerians question how Buhari got over 14 million votes in APC primary
Shekarau dumps PDP for APC after meeting with Oshiomole, Ganduje
Hospital in Ogun Contaminated After Unknowingly Treating COVID-19 Patient


text:
Single-person homes the next big investment strategy
Shifting demographic trends have been attracting a fair amount of attention in the media recently, something that all investors should be taking close note of.
I've found it interesting to note recently that the mainstream media in particular is starting to pick up on some of the evolving but dramatic changes in real estate trends.
I've talked about Australia's ageing population before, and the fact that many developers are moving towards smaller-sized or multi-use dwellings, rather than the traditional big house on a big block of land.
It wasn't too long ago that a four-bedroom house in the suburbs was the standard 'Australian dream', but a big family home doesn't suit everyone any more. In fact, these types of homes increasingly suit fewer and fewer segments of the population.
The fastest-growing household size, according to a new report, is single-person households. These could be older Australians, who are living longer than ever before, or younger Australians who choose to live on their own.
"Single people, for example, are waiting longer to get married or enter into a long-term relationship," says Professionals WA chief executive Shane Kempton in a recent media article.
As a result, certain property features are becoming more important to some buyers.
"Car parking and security features are very important when buying a home, because more single people are demanding higher levels of security, and these features can impact on the resale value of the property," Shane says.
Are you actively considering Australia's evolving demographic trends when reviewing your next investments?
Or do you truly believe that the big house on the big block will always have its market, so you'll continue to build your portfolio with freestanding homes as opposed to smaller apartments and units? Would love to know where you stand on this, feel free to comment!
Til next time, happy investing!


A man is tempted by an insidious, curvaceous force that feigns the feminine form and he slowly finds himself wound up like a ball of yarn for the cats' night out. That's how Vertigo begins, but only in the most superficial sense how it dissolves. It stars James Stewart as Scottie Ferguson, a private eye hired by a friend to spy on the friend's wife Madeline (Kim Novak), whom the man believes is possessed by a familial specter who has long overstayed her tenancy in the human body. Soon enough, Scottie finds himself in love, and perhaps so too does Madeline. Things truck along in ghostly romantic chiller fashion from this point on, but director Alfred Hitchcock couldn't resist slopping some blood on the tracks.
This entry was posted in Film Favorites, Review and tagged alfred hitchcock, Confrontational Classics, Film Favorites, jimmy stewart, Metatextual Madness, Score: 10/10, those films on December 24, 2014 by jakewalters98.
Perhaps no film director has been studied, debated over, written about, psychoanalyzed, copied, butchered, chastised, and celebrated as Alfred Hitchcock. Inevitably, the question always comes up: What's your favorite Hitchcock? A tough question, and admittedly not one I would retort to with Rear Window But if the question was "what is Hitch's greatest commentary on film?". Well, that's another story altogether.
This entry was posted in Film Favorites, Review and tagged alfred hitchcock, Film Favorites, jimmy stewart, Metatextual Madness, Score: 10/10 on July 22, 2014 by jakewalters98.
Psycho is often reductively referred to as the grandfather of all modern slasher movies. In some sense, that is perhaps true. It's one of Hitchcock's most clearly defined "horror films" (along with perhaps Frenzy), and it is ultimately about a killer. On these notes, it is undeniably effective, with Hitchcock's sense of mood and atmosphere slowly burning their way into the viewer's psyche and his editing and film construction famously giving more than a few people a lifetime fear of a certain means of personal cleansing.
But Psycho is much more than a superior slasher picture. Its center lies in audience expectation and implication, an exercise in subversion first and foremost. The first half of the film makes it quite clear that Marion Crane (Janet Leigh, a big star at the time as well as a typical Hitchcock blond and thus naturally the film's star going in) is to be the main character, a woman looking to embezzle money in order to run away with her lover, Sam Loomis. For nearly the first half of the film, we watch her meticulously fulfill her plan before arriving at the roadside Bates Motel, where she meets Anthony Perkins' Norman Bates. He's friendly but slightly unnerving, a little creepy, and socially awkward, and he seems tied down to his mother in ways we don't yet understand. We expect that the film will end up being about the relationship between the two. Furthermore, we assume Perkins will slowly come to obsess over Marion.
Not only do we assume this, but Hitchcock no doubt intended it. Many of his films, including almost all of his masterpieces, are about obsession in one form of another, and he clearly sets this film up knowing audiences at the time would expect the same. The difference here would be a female main character, perhaps finally reflecting Hitch's willingness to commit to a garish, oppressive, and furious full-on criticism of the male gaze by moving beyond Vertigo's uneasily likable but nonetheless ruggedly classical Scottie Ferguson and toward a more passive male figure, someone who was ultimately less powerful than either of the film's two female characters. Backing this up are the repeated visual images of Norman's mother in shadow, ever glancing and high-perched like a vulture from up in the Bates' house behind the motel. She never physically appears, and exists only as a shadow, and yet she still has full power over Norman. All in all, Hitch's set-up relies heavily and fundamentally on the viewer's knowledge of Hitch as a filmmaker.
Then, suddenly and with the confidence of a master, Hitch pulls the greatest trick ever played on an audience in a film. We all know by now that the obsession story ends with the shocking murder of Marion by who we assume to be Norman's mother, still bathed in shadow. The scene, famously taking place while Marion is in the shower, is a masterwork of framing and editing. Its list of techniques runs a mile wide, but the more notable include jarring quick-cutting, an ear-piercingly slashing and now famous score by Bernard Herrmann that sounds like humanity's nightmares on a chalkboard, the film's stunning black-and-white monochrome, essential to enhance the nightmarish detachment of the film, and a diabolical zoom outward from Marion's eye post-mortem. The scene has been written about to death, rightfully so for its astounding construction. Yet, we wonder where the film leaves us from here. Surely, the film isn't over?
The functional plot twist, it turns out, is no mere sick joke; it rearranges the texture and the nature of the film at a core, elemental level, playing on our expectations about stardom and cinema and slashing them to bits. It is not only narratively shocking but thematically subversive, rooted purely in audience expectation and Hitchcock's methodological, obsessive desire to control his protagonists and his audience as well. The film is his toying with us as he had always done with his characters – here he toys with a blond female, his favorite such figure, by literally setting her up as the main character and unceremoniously writing her out of the film. And he toys with the male lead by depicting him as a passive loser and yet essaying our sympathy toward him for his helplessness – we actually start to question ourselves and come to move back and forth between wanting Norman to escape his mother's grasp and seeing him as complicit in the actions as well. We become implicated in Norman's own personal tragedy, a tension expounded upon by Perkins' own slightly-off-center enigmatic unease of a performance. It's a scary proposition to court sympathy for such a character, but Hithcock was always about scary, unnerving propositions, something he never pulled off better than here.
If the film has a flaw, it's a small one. Late in the film, after the climax, a psychiatrist spends a couple of minutes delivering exposition about Norman and his mother that is downright saddening. Not only are these kinds of things best left unsaid, but the film has already gone to great effort to show us what it here feels the need to say. It's didactic and displays a lack of confidence for the usually assured Hitchcock, but it's a small flaw that does little to damage the reputation of a true masterwork.
Counterbalancing this however is the film's pure visual craftsmanship. It remains, for all its sub-textual questions and problematic concerns, replete with Hitchcock's finest camerawork and editing, even beyond the famous shower scene. Later on, there is a famous murder where a victim falls down the stairs while dying, given a hallucinogenic edge that captures better than anything in Vertigo (not a film about the fear of heights anyway) the pure, surreal sensation of falling. And of course there's the conclusion, whose defining feature is a light-bulb swinging back and forth as it illuminates and darkens the unfolding events like a garish, atomic ball of pure energy. Howard Hawks once said a "good" movie is a film with three great scenes and no bad ones. Well, this film has one bad scene, but matches it to these three aforementioned scenes which aren't great but monumental, along with plenty of great ones, all of which isn't to mention the very game-changing narrative bending of the film, something never done before nor repeated with the success seen here. Besides, I've always been more of a cohesive "full experience" viewer than the kind who weighs positives and negatives, and this film, as a full experience, is unnerving, subversive, and downright terrifying in its clinical descent into hell.
Of course, some of the impact has been diluted over the ensuing fifty years – it's less emotional than intellectual now, since many of us know how the story proceeds and have seen the multitudes of films which borrow heavily, and indeed owe their existence, to Psycho. Today, the film feels slightly more like a time capsule work to appreciate rather than to experience, but damn if that doesn't just make it all the easier to admire. Perhaps no other film in the history of cinema marks a before and after like this one- narratively, Hitch completely rewrote the book (for English language cinema at least – one need look no further than Antoniono's own L'Avventura released the the same year for a foreign language film that spent as much energy on completely destroying the logic of narrative filmmaking, but far fewer filmmakers have seen that film so by definition it is less "important" to the development of film). In a sense, this may be the most important film ever released.
But importance and film history, and even thematic nuance, take a backseat to Psycho's worth today. That's because Psycho has never been about thematic nuance – it is, at the end of the day, a direct distillation of just about the purest cinema Hitchcock ever produced, something ruthlessly efficient and purely dedicated to its own craftsmanship. It's his greatest stylistic achievement and his most visually energized and oppressively constructed film, designed with every scene to confuse and confront us and our expectations. He winds us up painfully and refuses to let go. If that wasn't enough, it is also a rather breathless commentary on filmic expectation and audience voyeurism that never once (well, only once) tells what it can show. The idea that a certain character must inevitably survive the film, that a certain lead actress must be the star, that films should follow a certain structure as they take us along with that star – all are subverted gleefully by the film's narrative structure. Hitch steadfastly and destructively confounds expectations and throws our role as an audience under the bus by quite literally rubbing our faces in our understanding of role and character in a film. Best of all is that Hitch accomplishes his technical mastery and his thematic wonders in perfect harmony, never once laying his themes on top of the film but always tackling the more difficult question of how to create the theme in the film itself. Theme in Hitch, as it always should, comes from form, even when so many other films make the mistake of doing it the other way around.
All of this, and it is a real wonder that Psycho is really nothing more than the famously bald director letting his hair down and playing with us. For what reason you ask? Sure, he plays for the sake of a commentary on filmic viewership and on masculinity and the male gaze. But his real reason is far more pure and giddier: he woke up one morning and thought it would be a fun thing to do before teatime. Remember, this is Hitch, a man for whom diabolical malevolence was synonymous with fun; he scrapes us along his ragged, angular celluloid surface like butter on the crumpet he eats to congratulate himself for a good day's fright.
This entry was posted in Film Favorites, Review and tagged alfred hitchcock, anthony perkins, Film Favorites, horror films, Score: 10/10, screwing with the audience on July 22, 2014 by jakewalters98.


12:2 One of these days, everything that's covered up and hidden is going to get put on display for everyone to see.
12:3 Everything you said under the cover of night is going to get repeated in the light of day. And everything you whispered in the privacy of a room is going to get broadcast everywhere.
12:4 Let me tell you something, friends. Don't be afraid of those who can kill you but then can't hurt you anymore.
12:5 I'll tell you who to be afraid of. Be afraid of the one who can kill you and then throw you into hell.2 Be very afraid.
12:6 You can buy five sparrows for two measly cents,3 can't you? Well, God would never forget a single one of those birds.
12:7 Here's another fact: every strand of hair on your head is numbered. Don't be afraid that you're forgotten or unimportant. You're worth more than a flock of sparrows.
12:8 Listen, if you speak up for me in front of other people, the Son of Humans4 will speak up for you in front of the angels of God.
12:9 But if you renounce me in front of other people, you are going to get renounced in front of the angels of God.
12:10 There's forgiveness for everyone who speaks out against the Son of Humans. But there is no forgiveness for those who slander5 the Holy Spirit.
12:11 When they arrest you and put you on trial in the synagogues, in front of rulers and officials, don't be intimidated. Don't worry about what to say when it comes time to defend yourself.
12:16 Then he told the people a parable. He said, "A rich man's farm produced a bumper crop.
12:18 Then he said, 'I know. I'll tear down my barns and build bigger ones. I'll store all of my grain there, along with my other stuff, too.
12:23 There's more to life than eating food and there are more important things for a body than clothing.
12:24 I want you to think about this. Ravens don't plant a garden. And they don't work at harvest time collecting the crops. Even if they did they wouldn't have a barn or granary to put it in. But you know what? God feeds them. People, how much more important are you than birds?
12:25 What good is it for you to worry if all the worrying in the world can't add one measly hour to your life?
12:26 If you can't even get that little thing done by worrying, why worry about anything?
12:27 Think about the lilies, and about how they grow out in the wild. They don't work. They don't spin fabric to make clothes for themselves. But I'll tell you this, not even King Solomon decked out in his best royal robes looked as handsome as a lily.
12:28 If God drapes such beauty on fields of grass, which tomorrow will be pitched in the oven and burned as fuel, how much more is he going to put clothes on you. My goodness, you people have so little faith.
12:29 Now listen, don't focus so much time and energy on thinking about what you're going to eat or drink. Don't get bothered by that.
12:30 These things are the biggest concern of every nation in the world. Your Father knows all too well that you need them.
12:31 So instead of focusing on them, make his kingdom your biggest concern—your top priority. When you do, he will give you what you need.
12:32 Don't be afraid little flock. Your Father is giving you the kingdom. And he's delighted to do that.
12:33 Go ahead and sell things you own and give away the money you get for it. Donate it to needy folks. That's how you make money bags that never wear out. They'll hold a treasure in heaven that no thief can steal and no moth can eat through.
12:34 Wherever you keep your treasure, that's where you'll find your heart.
12:35 Put your clothes on and light your lamps.
12:36 Think of yourselves as a group of workers waiting for your boss to get back from his honeymoon.7 You want to be ready when he comes and knocks on your office door.
12:37 Consider yourself fortunate if you're one of the workers the boss finds awake and on the job. He'll reward you for that. The boss himself will seat you at a table and treat you to a nice meal.
12:38 The boss may come during the night shift—in the middle of the night or just before daybreak. It will be good news for you if he finds you working, for those are the ones who will get the reward.
12:39 Listen to me. If a homeowner knew exactly when a thief was going to break into his house, you can bet the homeowner would be ready. No way would the thief get in.
12:40 You, too, need to get ready for an arrival. The Son of Humans is coming, and you have no idea when to expect him."
12:42 The Lord said, "Who is the dependable and sensible worker that the boss can put in charge of the other workers, and make sure they take their lunch break at the right time?
12:43 When the boss shows up, that worker will get a nice reward for doing a good job.
12:44 I'm telling you the truth, the boss will put a supervisor like that in charge of everything.
12:45 But let's say the worker thinks the boss won't show up anytime soon, so he begins to mistreat the other workers. And instead of doing his job he stuffs himself with food and he gets himself good and drunk.
12:46 When the boss shows up unexpectedly and sees what's going on, he'll shred that worker and send him on his way to that place where unreliable workers go.
12:47 That worker who knew what his boss wanted done but didn't do it will get beaten up.
12:48 On the other hand, a worker who didn't know what the boss wanted, so he didn't do it—that worker won't be punished as severely. For those who have been given a lot, a lot is expected. The more someone has been given, the more they must give.
12:49 I have come here to set this world on fire. I wish it were burning now.
12:50 There's something I need to do, and it's going to weigh heavy on me until I get it done.
12:51 Do you really think I came to bring peace on earth? Absolutely not. I'm telling you that my being here is going to have the opposite effect. I'm going to cause divisions.
12:52 From now on, if you have five people in your home, three of them will take a side against the other two, and those two against the other three.
and the son won't agree with his father.
and the daughter won't agree with her mother.
12:54 Jesus said to the people in the crowd, "When you see clouds building in the west, you say, 'It's gonna rain.' And sure enough, it rains.
12:55 And when the wind starts blowing in from the south, you say, 'We've got some hot weather coming.' And what do you know. Here comes the hot weather.
12:56 Frauds.8 You know how to read the signs in the sky about what's going to happen in the future. Why is it you can't tell what's happening right now?
12:57 Why don't you go ahead and decide for yourself the right thing to do?
12:58 For example, when you find yourself heading to court, try to reach a settlement before you get there. If you don't, your opponent will take you to the judge, the judge will turn you over to the bailiff, and the bailiff will show you the way to prison.
This is a clever metaphor, given that Jesus has just come from eating a meal with Pharisees. Yeast pervades all the dough in a baker's loaf of bread; it's everywhere mixed into the dough. Hypocrisy works that way on the Pharisees; that's what many Bible experts say is the point Jesus was making.
The Greek word is Gehenna, and it's Hinnom in the Hebrew language of the Old Testament. That's the name of a valley on the south side of Jerusalem. It's the place where some Jews used to sacrifice to idols – including some human sacrifices (2 Chronicles 28:3). These were sins that many Jews came to believe were the reason God allowed Babylonians from what is now Iraq to temporarily wipe the Jewish nation off the world map in 586 BC, exiling the Jewish survivors for a generation. In time, Gehenna came to symbolize the judgment of God.
The coins are two assaria. It takes 16 of them to make a denarius. A denarius was considered a day's wage for a common worker.
The word is more literally "blaspheme." It's not clear what Jesus meant by this. Matthew reports that Jesus said this after some Pharisees accused him of casting out demons by the power of Satan (Matthew 12:22-27). Given that context, some scholars say the sin is crediting Satan with a miracle performed by the Holy Spirit. Others suggest it is simply a person's persistent unwillingness to believe that Jesus is the Son of God. For people who fear they have committed the unforgivable sin, Bible experts point them to 1 John 1:9, which says that if we confess our sins, God will forgive us. Period.
More literally, "about your body." It's unclear what Jesus had in mind.
More literally, from the wedding feast.
Jesus uses the idea of yeast to describe how hypocrisy affects everything the Pharisees do (12:1). For those of you who bake with yeast, what would make that a good illustration?
Jesus tells the crowds that one day "everything that's covered up and hidden is going to be put on display for everyone to see" (12:2). What do you think he's talking about? Is he talking about Judgment Day, or perhaps about the way secret sins eventually tend to find their way to the surface, or possibly something else?
When Jesus says we should be very afraid of "the one who can kill you and then throw you into hell" (12:5), is he talking about God? And if so, how comfortable do you feel about the God of love doing something like that?
Jesus tells the people not to worry about what to say when they are put on trial because of him. He says "The Holy Spirit will give you the right words at the right time" (12:12). Do you think advice like that is for us today, or just for the people in that generation?
Jesus told the people, "Defend yourself against greed" (12:15). Given that we never know how much we are going to need for future costs such as healthcare, retirement, assisted-living, how can we know we have gone overboard in building up assets for expenses like that? When is it greedy?
Jesus told his disciples not to worry about "everyday matters of life" (12:22), such as food and clothing, along with what's going to happen if we get sick. How is that not crazy talk?
Jesus told the people, "Don't focus so much time and energy on thinking about what you're going to eat or drink… Your Father knows all too well that you need them" (12:29-30). What do we have to say for God when people remind us that not everyone has enough to eat or drink?
Jesus tells a parable about workers being ready for when the boss shows up. And he does it as a way to illustrate that we should be ready for the arrival of the "Son of Humans" (12:40). Could he be talking about his arrival in that generation, or do you think it's more likely he's talking about his future return? Either way, how does someone get ready to receive him?
LIFE APPLICATION. Pastors say one of the most common questions they get during counseling with people who know at least a little about the Bible is that they are afraid they are going to hell because they send against the Holy Spirit. Mark said, "There is no forgiveness for those who slander the Holy Spirit" (12:10). That shocking quote from Jesus shows up in the Gospels of Matthew (12:31-32) and Mark (3:29) as well. It sounds as though we could be in big trouble if we give the Holy Spirit a good cussing out. What's a pastor to say?
LIFE APPLICATION. Let's answer the question Jesus asked: "If all the worrying in the world can't add one measly hour to your life….Why worry about anything? (12:25-26). Is there any value to worrying?
LIFE APPLICATION. Jesus said he did not come to bring peace on earth he said "My being here is going to have the opposite effect. I'm going to cause divisions" (12:51). How have you seen that happen?


text:
We have long known that GH release is stimulated by catecholamine
We have long known that GH release is stimulated by catecholaminergic mechanisms, among others. For almost 30 years now, different GH stimulation tests have been used to prove whether GH response in depressed patients differs from controls and subjects with other psychiatric diseases. Most revealed significant differences between patients with major depression and healthy subjects or patients with minor depression, using various specific substances to challenge GH response. Patients with recurrent major depression exhibited a blunted GH Inhibitors,research,lifescience,medical response, which could be interpreted as cither decreased DA receptor sensitivity (challenge with apomorphine) or decreased α2-adrenoceptor sensitivity
(challenge with clonidine).80 It was further suggested that this blunted GH response to clonidine was Inhibitors,research,lifescience,medical a trait marker that persists in depressed patients following their recovery.81 -82 However,
as challenge with different α2-adrenoceptor-selective agents resulted in a normal GH response, an intrinsic abnormality in the GH system was also suggested as opposed to decreased a2-adrenoceptor sensitivity.83 Alterations in thyroid function have been Inhibitors,research,lifescience,medical repeatedly linked to depression and the administration of triiodothyronine (T3 ) seems to be an effective adjunctive treatment for many patients.84,85 The relationship between thyroid hormones and neurotransmitters have mainly focused on the noradrenergic and serotonergic systems and it was shown that thyroid hormone application increases cortical serotonin release86 and may act as a cotransmitter to Inhibitors,research,lifescience,medical NE in the adrenergic nervous system.87 However, the exact mechanism of this interaction is not clear. Especially intriguing was the observation that 5-HT function was especially reduced in patients without hypothalamus-pituitary-thyroid
axis abnormalities, which suggests that mechanisms that are not serotonergic might be involved in the reduced secretion of thyroid-stimulating hormone (TSH).84 A further hint Inhibitors,research,lifescience,medical on the influence of hormones comes from the fact that the immediate postpartum period is a time of highly increased also risk for the onset or relapse of depression.88 Several results underline the influence of estrogen and progesterone,89 thyroid hormones,90 or alterations in the HPA axis,91 but the direct mechanisms have not been clarified. In addition, recurrent depressive symptoms can be limited to the premenstrual period and more enduring depression is typically exacerbated premenstrually. These findings on possible disturbances in sex hormones could give an explanation for the increased incidence in women. Neuroimmune mediators The clinical course of depression is that of a variable disease with long periods of recovery between periods of depression in many patients, but it can also involve Epigenetic inhibitor closely spaced episodes that finally lead to a severe and unremitting course.
These authors found that isolates presented at the start of a li
These authors found that isolates presented at the start of a list were remembered better than standard words, even though there was not yet a context to make them distinctive. This finding, and ours, suggests that the von Restorff effect is not produced by novelty processing, but by other mechanisms. However, there are also studies with findings that contradict ours. Several studies have found that recalled isolates elicited
larger P3s at study than nonrecalled isolates (Fabiani et al. 1990; Fabiani and Donchin 1995; Otten and Donchin 2000). This was only the case when color was used to make words distinctive and not when this was done with a surrounding frame (Otten and Donchin 2000), and only when participants were Inhibitors,research,lifescience,medical instructed to use rote rehearsal as their learning strategy, not Inhibitors,research,lifescience,medical when elaboration was used (Fabiani et al. 1990). Wiswede et al. (2006) found a larger P3 for both recalled isolates and recalled standard words as compared with not-recalled words. In all of these studies, immediate free EPZ-6438 solubility dmso recall was used to test memory. We tested memory with delayed cued recall and recognition. Our contradictory findings suggest that P3 amplitude indexes a process
that helps in free recall, but not cued recall or recognition. One candidate for such a process is attention to the unique, novel feature itself. In free recall, but not cued recall or recognition, features such as color Inhibitors,research,lifescience,medical or font size can be used as cue to retrieve the word. For
example, in our study only one of 80 words was presented in green font. This would Inhibitors,research,lifescience,medical probably make "green" a good cue to retrieve this word in free recall. Thus, in free recall, the "green" word would often be recalled (see McDaniel et al. 2005 for a discussion of similar retrieval-based accounts). By contrast, during Inhibitors,research,lifescience,medical cued recall, participants cannot search their memory for a green word, as they would not know for which word stem cue "greenness" would be of any help in retrieval.2 If the P3a indeed indexes attention to the novel feature, this would thus aid free recall of isolates (Karis et al. 1984; Fabiani et al. 1990; Fabiani and Donchin 1995; Wiswede et al. 2006), but not cued recall. It would also, presumably, aid more in designs in which there was just a single isolate until per list, as opposed to more than one as in our design. Whether this is the case, it is clear that a von Restorff effect can be found for isolates that do not elicit larger P3s, for example, when isolates are made distinctive with a surrounding frame (Otten and Donchin 2000) or when elaboration is used (Fabiani et al. 1990; our results). Moreover, Fabiani and Donchin (1995) reported larger P3s for recalled as compared to not-recalled isolates in conditions where no von Restorff effect was found: for semantic isolates when participants were asked to focus on physical appearance, and for a recognition task that followed lexical decision.
(Fig 3B3B i) Extensive demyelination occurred at sites of cell
(Fig.3B3B i). Extensive demyelination occurred at sites of cell infiltrates in vehicle-treated EAE mice as compared to normal controls. Significantly less demyelination occurred in nearly all LQ-treated spinal cords (Fig. (Fig.3B3B i). Quantification of demyelination in vehicle-treated EAE mice by analysis of MBP staining density in delineated dorsal columns revealed a ~35% (P < 0.001) decrease
in myelin density as compared with normal controls (Fig. (Fig.3B3B iv). In contrast, myelin staining was preserved in 5 mg/kg pre-EAE, 25 mg/kg pre-EAE, and 25 mg/kg early post-EAE LQ-treated dorsal columns, whereas the 5 mg/kg early Inhibitors,research,lifescience,medical post-EAE LQ-treated dorsal columns showed a trend toward increased MBP intensity but did not significantly differ from the vehicle-treated EAE group (Fig. (Fig.3B3B iv). Considerable evidence now Inhibitors,research,lifescience,medical indicates that axonal injury is prominent in MS and EAE, and it suggests that axonal injury plays a prominent role in the progression of clinical signs (De Stefano et al. 2003). Here, potential axonal pathology was evaluated using NF200 and a prototypical marker of axonal damage, APP. In comparison with normal controls, EAE mice exhibited UMI-77 datasheet numerous APP+ axons and a significant reduction in the total number of NF200+ axonal profiles in the dorsal column (data not Inhibitors,research,lifescience,medical shown) and ventral funiculus (Fig. (Fig.3B3B ii). In comparison with vehicle-treated EAE mice, pre-EAE and early post-EAE
LQ-treated Inhibitors,research,lifescience,medical mice exhibited an increase in number of NF200+ and significantly less APP+ axonal profiles (Fig. (Fig.3B3B ii, v, vi). To assess the myelination status of NF200+ axons in the spinal cord of LQ-treated EAE mice, double immunostaining
with antibodies to MBP and NF200 revealed relatively intact myelin rings (red) around axons (green) in normal and LQ-treated EAE mice (Fig. (Fig.3B3B iii, vii). Quantification of NF200 staining in the ventral funiculus Inhibitors,research,lifescience,medical revealed 49 ± 12% (P < 0.001) reduction in myelinated axons of vehicle-treated EAE mice compared to healthy controls. Significant increase in myelinated axons was observed in LQ-treated pre-EAE and early post-EAE groups as compared to vehicle-treated EAE group (Fig. (Fig.3B3B vi–vii). Treatment with LQ decreases EAE-induced callosal conduction and myelination deficit We have recently shown that CNS structures (i.e., CC, hippocampus, and cerebellum) other than the tuclazepam spinal cord are negatively affected during EAE (MacKenzie-Graham et al. 2009; Ziehn et al. 2010; Mangiardi et al. 2011; Kumar et al. 2013), leading to sensory, motor, and cognitive impairments similar to those seen in MS patients. Callosal white matter tracts from EAE brains showed many periventricular infiltrating lesions around blood vessels (white dashed box) and scattered throughout the white matter accompanied by microglia/macrophage and reactive astrocyte accumulation and a marked decrease in PLP_EGFP+ OLs (Fig. (Fig.4A4A i; also see Mangiardi et al. 2011).
39 Modifications of gene expression: the regulation of BDNF trans
39 Modifications of gene expression: the selleckchem regulation of BDNF transcription The BDNF gene has a complex structure that underscores its potential for regulation. According to the available updated nomenclature, the gene encompasses at least eight noncoding 5′ exons that can be spliced to a single 3′ exon containing the coding domain for the BDNF protein, generating 11 different, transcripts according to the last, studies. The previous nomenclature of BDNF transcripts (exons I to V) in the literature cited below has been translated here to the updated nomenclature.51 The regulation of promoter in exon IV has Inhibitors,research,lifescience,medical been extensively characterized.21,52 The functional difference among the different.
BDNF transcripts has not been widely explored thus far but, being among those genes whose
transcripts are translocated to different cellular compartments, the delivery of different, transcripts may subserve the availability of the message at cell soma, dendrites, axons, according to the needs of plasticity.53 Exon V-containing Inhibitors,research,lifescience,medical transcript, has been detected in both soma and dendrites, while exon IV-containing transcript expression was found to be limited to the cell body.54 A number of studies have analyzed the expression of exons I, II, IV, and V (in the updated nomenclature) in relation to antidepressant, treatments, physical exercise, and stress paradigms Inhibitors,research,lifescience,medical Inhibitors,research,lifescience,medical (reviewed in refs 25, 39). Interestingly, chronic defeat stress, a model of depression, has been shown to downregulate in mouse hippocampus the expression of BDNF IV and V transcripts, by inducing increased repressive histone methylation at respective promoters.55 Chronic imipramine treatment reversed this downregulation and increased histone acetylation at these promoters, a modification associated with chromatin decondensation and facilitation of gene transcription, underscoring the
role of cpigcnetic mechanisms in stress response and antidepressant mechanisms. Recently, we have analyzed for the first, time the complete pattern of expression of the several BDNF transcripts ADAMTS5 after treatment Inhibitors,research,lifescience,medical with two different antidepressants, fluoxetine and reboxetine, as an attempt to identify molecular signatures of different, drugs. In hippocampus, fluoxetine induced BDNF III and IXa and downregulated IV; reboxetine induced VI and IXa and downregulated I and IV The main difference between the drugs was that, fluoxetine selectively induced BDNF III and reboxetine VI. In prefrontal/frontal cortex fluoxetine induced transiently (first. 2 weeks) BDNF I and VI, and persistently III and IXa, while it downregulated IV; reboxetine also induced III and IXa. The main difference here was that fluoxetine, in addition to the same two transcripts induced by reboxetine, transiently induced exons I and VI and downregulated IV (Musazzi et al, unpublished data).
For example, in a study of an Ashkenazi Jewish population, the pr
For example, in a study of an Ashkenazi Jewish population, the presence of HNF4A or WFS1 SNPs was each associated with modestly increased risk of DM, while the presence of both increased that risk three-fold.17 Unfortunately, although genome-wide association studies have already identified over 65 gene variants related to DM2,18 predominantly involved in β-cell function,19 collectively they explain only a small portion (<10%) of DM2 heritability.20 Thus, while family history
of DM approximately doubles the risk of developing DM, the genetic Inhibitors,research,lifescience,medical variants associated with DM risk have only a small effect on the ability to predict the future development of Inhibitors,research,lifescience,medical the disease.21 It is very likely that epigenetic changes contribute to familial clustering of risk for obesity and DM,22 changes that by definition are not detectable with genomic studies. In contrast to DM2, a small number of monogenic defects have been recognized to cause the uncommon autosomal dominantly inherited forms of maturity-onset diabetes of the young (MODY).23 These Inhibitors,research,lifescience,medical defects disrupt β-cell function, and their recognition and precise genetic diagnosis is clinically important in directing treatment towards more effective and easier-to-use sulfonylurea drugs rather than insulin. The most common form (MODY3) results from
a mutation of hepatocyte nuclear factor-1α on chromosome 12.24 In MODY2, a defective glucokinase gene on chromosome 7P results in disturbed β-cell sensing of glucose concentration. Transcriptomics and Type 2 Diabetes Mellitus Sometimes referred to as gene expression Inhibitors,research,lifescience,medical profiling,
transcriptomics is the quantitative study of all genes expressed in a given biological state25 and measures all of the various RNA forms (messenger, ribosomal, transfer, etc.) produced by DNA transcription in a particular cell or Inhibitors,research,lifescience,medical tissue. MicroRNAs are small, non-coding RNAs that are involved in control of gene expression and play an important role in regulating metabolic and cardiovascular processes.26 In combination with metabolomics, transcriptomic studies in animal models of DM have identified a number of novel genetic and metabolic changes, including differences in branched-chain amino acids, nicotinamide metabolites and pantothenic acid, that provide direction for additional studies of diabetes most selleck inhibitor pathophysiology.27 Proteomics and Type 2 Diabetes Mellitus Techniques such as matrix-assisted laser desorption/ionization,28 mass spectroscopy, and electrospray ionization,29 alone or in combination, are used to identify and quantify all of the large number of protein products of a genome, in a specific tissue or body fluid. Differences associated with obesity, DM, or other disease states may identify novel pathogenic mechanisms, prognostic markers, or potential therapeutic targets.
Euphorogenic effects, which have been described as enhancing abus
Euphorogenic effects, which have been described as enhancing abuse liability, are also a component of the discussion of psychological dependency. Table I. Characteristics of the substance dependence syndrome. "Physiological dependence" is present if either Item 1 or Item 2 is applicable. Adapted in part from reference 1. Benzodiazepines First introduced in the 1960s with the appearance of chlordiazepoxidc and diazepam, the benzodiazepines quickly Inhibitors,research,lifescience,medical supplanted
the barbiturates as the preferred treatment of most, anxiety disorders.18,19,42 They have shown efficacy in both acute and chronic anxiety states, and they have a wide margin of medical safety. As a class, they also have utility as anticonvulsants, Inhibitors,research,lifescience,medical muscle relaxants, hypnotics, and adjuncts to anesthesia and conscious sedation. Some effects, such as sedation and anterograde amnesia, are a desirable effect in certain settings, such as in the treatment of insomnia or in the endoscopy suite, but are considered undesirable side effects under circumstances such Inhibitors,research,lifescience,medical as the treatment, of anxiety. Tolerance appears to develop over time to some of the sedating properties of the benzodiazepines. Tolerance to other effects also seems to occur, but along distinctly different time courses, suggesting mechanistic differences. Abrupt, discontinuation can lead to insomnia and anxiety after more than a couple of weeks of using short-acting benzodiazepines to treat, sleep disorders.
Patients who have been receiving daily therapy with longer-acting agents for anxiety and other diagnoses, and whose therapy has been suddenly halted or reduced, can experience a range of withdrawal Inhibitors,research,lifescience,medical symptoms.18 These are usually mild and transient, and may include both psychological and physical symptoms. Heightened anxiety, tremor, tachycardia, and photophobia are some of the symptoms that, are often reported. In extreme cases following prolonged therapy with high doses, seizures and delirium can occur. The duration of therapy, dose of medication, and manner in which therapy is discontinued are all important determinants of whether
a withdrawal syndrome Inhibitors,research,lifescience,medical will occur and how severe it will be. It is important to keep in mind that other medications that are not, thought of as having dependence liability also cause a physiologic Sodium butyrate "rebound" or other pronounced adverse effects if stopped abruptly. βP- Adrenergic blockers are one example of such a medication. These drugs are therapeutically important, in patients with hypertension and coronary artery disease, with proven efficacy in reducing actual Afatinib mortality in some cohorts, but they can result in a withdrawal syndrome if therapy is suddenly stopped. Signs and symptoms can include a return of hypertension as well as tremor, palpitations, and sweating, and can be as severe as the precipitation of arrhythmias and unstable angina, in patients with severe underlying coronary disease.
In a prospective study of 114 patients presenting to the emergenc
In a prospective study of 114 patients presenting to the emergency room with "suspected cardiac chest pain", myocardial perfusion defects demonstrated 77% sensitivity for the detection of ACS compared to 28% and 34% respectively with ECG and troponin while maintaining similar specificity (89-96%).25) LEE011 research buy Abnormal myocardial perfusion was the only independent variable for diagnosing an ACS (odds ratio = Inhibitors,research,lifescience,medical 87, p < 0.001). The short and long-term prognostic significance of MCE has also been shown in chest pain
patients.26) Patients with abnormal perfusion were 2.5-fold more likely to have non-fatal myocardial infarction or cardiac death, but those with both abnormal regional function and myocardial perfusion were 14.3-fold (p < 0.001) more likely to have events - demonstrating the incremental benefit of combined wall thickening and perfusion Inhibitors,research,lifescience,medical data over regional function alone in these patients. The diagnostic and predictive value of contrast echocardiography in acute chest pain is limited by a number of factors, however. When a patient has only ischemia but no infarction, wall thickening abnormalities (stunning) resolves
over time Inhibitors,research,lifescience,medical – so perfusion and function may both have returned to normal if a patient presents late after their insult. In patients with prior infarction, it may be difficult to determine if a wall thickening abnormality is due to acute ischemia, or to remote infarction. In such cases, Inhibitors,research,lifescience,medical targeted imaging to identify recent ischemia-reperfusion injury (ischemic memory imaging) may be very valuable. In one study, Ley et al.26) chose to detect the presence of P-selectin upregulation after ischemia. P-selectin is an endothelial adhesion molecule which is transported to the endothelial cell Inhibitors,research,lifescience,medical surface rapidly after an inflammatory stimulus, where it participates in leukocyte capture and rolling on the venular surface.26) The presence of P-selectin
can persist for many hours after the initial injury. The anterior myocardium of mice were subjected to 10 min of ischemia followed by 45 min of reperfusion to allow recovery of resting function. Biotinylated microbubbles conjugated with a monoclonal 3-mercaptopyruvate sulfurtransferase antibody targeted against P-selectin were administered after reperfusion and showed selective retention and contrast enhancement of the post-ischemic anterior wall at a time when both myocardial perfusion and wall thickening had normalized.27) In Fig. 4, P-selectin targeted microbubbles were administered in open-chest dogs which had been subjected to 90 min of ischemia followed by reperfusion. The area of contrast enhancement has been color-coded so that green to yellow to red reflect greater signal intensity. Panels A and B demonstrate separate animals with left anterior descending (Fig. 4A), and left circumflex (Fig. 4B) territory ischemia followed by 60 min of reperfusion.
Bleuler's approach was also notable for other reasons First, hi
Bleuler's approach was also notable for other reasons. First, his reformulation of dementia praecox as "the group of schizophrenias" foreshadowed the modern view that schizophrenia is a heterogeneous group of disorders with similar clinical presentations. Second, Bleuler included defects in affect as a core feature of the disorder. Third, his view of schizophrenia allowed for the possibility
of remission or recovery. Kraepelin's and Bleuler's observations provided the foundation for contemporary systems Inhibitors,research,lifescience,medical of psychiatric classification, including the International Classification of Disease and Death (ICD) and the American Psychiatric Association's DSM. These systems have thus benefited from incisive clinical observations of, and conceptualizations about, schizophrenic illness. They also, however, inherited the limitations of Kraepelin and Bleuler's efforts at classification and diagnosis. The first DSM definition of schizophrenia was vague, unreliable,
and allowed for too much discretion on the part of clinicians. As a result, apparent geographical differences Inhibitors,research,lifescience,medical arose in the rates of schizophrenia. In the United States, schizophrenia became the diagnosis of choice for psychotic conditions that lacked a clear "organic" etiology, and thus appeared to occur more frequently than it did in the United Kingdom.3 DSM-II continued'the DSM-I Inhibitors,research,lifescience,medical tradition of unreliable diagnoses, although it did incorporate the issue of differential diagnoses. Inhibitors,research,lifescience,medical Both of these early systems BLZ945 supplier viewed psychosis as a key feature of the disorder (we use the term psychosis to encompass hallucinations, delusions, and gross disorganization of thought or behavior). Interestingly, however, and despite its emphasis on psychosis, DSM-II did contain a nonpsychotic subtype of schizophrenia, called latent schizophrenia, which Inhibitors,research,lifescience,medical included a heterogeneous group of patients who in DSM-I were diagnosed with "incipient" or "borderline" schizophrenia, among other conditions. As the term "latent" implies, however, the category was intended to encompass individuals with underlying or occult psychotic conditions, instead
of identifying individuals who had schizophrenia in the absence of psychosis. Nevertheless, the category did represent an important out attempt to delineate the role of psychosis in schizophrenia. DSM-III resulted largely from the efforts of the "neo Kraepelinian" movement of the 1960s and 1970s,4 and from the efforts of other investigators in psychiatry and clinical psychology who argued for empirical, psychometric validation of psychiatric syndromes (eg, reference 5). DSM-III represented a marked shift from previous DSM.s, and contained a number of innovations, like field tests of diagnostic reliability, specific inclusion and exclusion criteria for diagnoses, multiaxial diagnosis, and a focus on the description of syndromes and course of disorders rather than inferences about their etiology.
While similar to older multikinase inhibitors such as sorafenib a
While similar to older multikinase inhibitors such as sorafenib and sunitinib, selleck screening library regorafenib also has structurally and biologically unique properties allowing for its use when tumors become resistant to these older agents. Phase III clinical trials of regorafenib in gastrointestinal stromal
tumors that developed resistance to imatinib and sunitinib have shown increased medial Inhibitors,research,lifescience,medical progression free survival compared to placebo (25). Similarly, in colorectal cancer median overall survival was 6.4 months in the regorafenib group versus 5 months in the placebo group (26). We will review the side effects of similar multikinase-inhibitors, sorafenib and sunitinib, and present what is known to date to occur from Regorafenib. Sorafenib targets B-RAF, VEGF-2, C-KIT, fetal liver TK(Flt)-3, and PDGFR. It is associated with hand-foot skin reaction (HFSR) and splinter hemorrhages as well as a seborrhea-like facial rash and a follicular rash on the trunk and extremities. Inhibitors,research,lifescience,medical Sunitinib targets VEGF-2, C-KIT, Flt-3, and PDGFR. It is associated with HFSR and splinter hemorrhages plus hair depigmentation, skin discoloration, Inhibitors,research,lifescience,medical and neutrophilic dermatoses. HFSR
can occur with regorafenib, and has long been a known side effect of multikinase inhibitors such as sorafenib and sunitinib. HFSR from multikinase inhibitors is a unique cutaneous toxicity pattern that should be distinguished from acral erythema (also known as hand foot syndrome and palmoplantar dysthesthesia) seen with classic cytotoxic chemotherapy. Patients Inhibitors,research,lifescience,medical with HFSR from multikinase inhibitors experience acral pain and dysesthesia, but usually to a lesser extent and with
less edema than when caused by chemotherapy agents such as 5-flourouracil, doxorubicin, and cytosine arabinoside. The most characteristic feature of HFSR is the development of palmar and plantar hyperkeratotic plaques (Figures 8,,9).9). These occur most often over areas of friction. During treatment with sorafenib and sunitinib, high grade hand-foot skin reactions have been reported Inhibitors,research,lifescience,medical to occur in up to 9% of cases resulting in impaired functionality from blisters and ulceration (27). Nardone et al. found these drug induced Sodium butyrate hand-foot skin reactions negatively impacted the patients' health-related quality of life scores (28). Figure 8 Hyperkeratotic plaques on areas of friction from regorafenib Figure 9 Hyperkeratotic plaque on thumb from regorafenib Hand and foot skin reactions are known to occur in patients receiving regorafenib for the treatment of metastatic adenocarcinoma of the colon. Often several weeks after starting the medication painful blistering plaques or rash develop on the feet and tender thickened plaques may develop on fingertips. This rash may affect activities of daily living because of the blistering, thickening, and discomfort that is frequently most severe at pressure points such as balls of the feet and fingertips.
Therefore, it might not be possible to know that the presented re
Therefore, it might not be possible to know that the presented results were
applicable to which group of family members. For instance, if children were infants or adolescents, then it remains speculative as how could they help the patient by referring to Behavioral Counseling Center. Therefore, it would have been better to select a more detailed sample so that the results could be generalized to all groups of family members. In conclusion, although the statistical Inhibitors,research,lifescience,medical tests employed were appropriately selected for the type of research design used in the paper, the selected research design was not appropriate for a number of reasons such as the effect of confounding variables including simultaneous events, impact of pretest findings on post-test ones, and statistical regression. Such confounding variables could be a source for extraneous variances, which may prevent the understanding of the relation between changes and independent variable. 4-6 One-group designs are appropriate when we try to change a confirmed or resisting characteristic, when we are able to remove Inhibitors,research,lifescience,medical disturbing factors with a high degree of confidence, or when we are able to ignore these factors or their effects. However, considering CX-5461 mw remarkable developments in research Inhibitors,research,lifescience,medical and publications
in medical sciences, and the judgments of world community about our published papers, we should pay more attention to the design of our studies as well as to the writing of our papers.
Background: It is well known that there Inhibitors,research,lifescience,medical is a close relationship between elevated androgen plasma levels and the ultrasound findings of stromal hypertrophy in polycystic ovary syndrome (PCOS). The objective of this study was to investigate the effects metformin on the hyperandrogenism and ovarian volume in PCOS. Methods: The study is an unrandomized clinical
trial with before–after design. Twenty eight patients with infertility (male Inhibitors,research,lifescience,medical or female factor) meeting the Rotterdam ESHRE/ASRM criteria for PCOS were studied during the 2008-2009. The anthropometric characteristics of the patients, mean bilateral ovarian volume, and morphology by trans vaginal sonography as well as the plasma levels of leutinizing hormone, follicle stimulating hormone, estradiol, testosterone, 17-α-hydroxyprogesterone, and dehydroepianderosterone sulfate were obtained before and after treatment with metformin (500 mg three Histamine H2 receptor times a day) for three months. Paired t, Pearson's Correlation Coefficient, or Partial Correlation test was used to analyze the findings. Results: The patients had a mean age of 25.67 years. A significant reduction in mean ovarian volume (11.70±4.31 ml vs 8.27±3.71 ml P=0.001), body mass index (BMI, 28.11±4.55 kg/m2 vs 26.84±4.55 kg/m2 P=0.000) and serum androgen levels was seen after three months of treatment with metformin. There was positive correlations between the ovarian volume and serum testosterone level (r=0.589, P=0.001) or BMI (r=0.663, P=0.000).


Friends, Romans, countrymen, lend me your ears. This Sweet Potato Breakfast Hash is so fantastically easy to make, and delicious, you'll be waxing poetic after one bite! It's paleo, and great for a grain-free breakfast to meal prep and reheat to serve on its own or with eggs.
One of the sad truths I learned very quickly after going paleo is that there is a dearth of breakfast paleo side dishes to go with eggs. I mean what good is a yolky egg, without something to drag through it? It's just not the same.
It was pretty soon after making this unfortunate discovery that I started making this paleo sweet potato breakfast hash. And then all was right with breakfast again! Basically it goes like this: I make a batch on Sunday for breakfast, then just reheat an individual portion to go with my eggs during the week. It's so easy to reheat and really makes a satisfying accompaniment to eggs. And it goes without saying that dragging a forkful of this hash through your egg yolk is highly recommended!
Sweet Potato Prep: Peel the Sweet Potato. The skin of the sweet potato is actually quite good for you, but I think the texture of it is distracting and papery when left on in this hash recipe.
Cooking Tips: Use a non-stick pan to keep the sweet potatoes from sticking to the pan. I have a Green Pan and I think it works great. (That's an affiliate link.) It doesn't have any toxic chemicals in the coating, and is made with a ceramic coating.
Add veggies for bulk and flavor: Before adding the sweet potatoes to the skillet soften and brown some onion and red bell pepper. This adds great overall flavor and adds more lower calorie veggies to the overall dish.
Add Sweet Potato: Next add in the sweet potato, and let it start to brown a bit. This takes about 5 minutes. Then add in broth and cover the whole skillet to let it simmer and soften the sweet potato. If you want this recipe to be vegan or vegetarian, use vegetable broth. I like Imagine No Chicken. Or if you aren't meatless, you can use chicken broth if you want.
It goes without saying that two eggs are a match made in heaven to go with this hash. But if you're still looking for ideas, here are some options.
If you aren't paleo, you could serve this easy ham and asparagus bread pudding.
If you want to try a grain-free egg casserole, this Chard and Egg Bake is totally foolproof.
Simply sizzling some ham in a skillet would be great with this, or you could make maple candied bacon for a decadent treat.
Fresh fruit is always a good idea too. For a crowd, this melon salad is a winner.
We had this one night with our chicken tacos, as a side dish!
If you're serving this hash at a brunch for a larger group, then some sort of baked good would be great. I love this parsnip coffee cake or for the paleo folks, you could make these paleo raspberry chocolate muffins.
Or you could have it all on its own. Just sayin'.
Sweet Potato Breakfast Hash is a easy grain free side dish to meal prep. Paleo and vegan friendly.
Heat 1 tablespoon oil in a large non-stick skillet over medium-high heat. Add onion and pepper and cook, stirring often until the onion just begins to brown, about 4 to 5 minutes. Add sweet potatoes and cook, stirring often, until the sweet potatoes are browned in a few places, about 6 minutes.
Add broth, cover and bring to a simmer. Reduce heat to medium-low and continue simmering, removing lid to stir often, until the sweet potatoes are starting to soften, about 12 minutes.
Add the remaining 1 teaspoon oil and stir to coat. Add salt, paprika, Italian seasoning, garlic powder and ground pepper and stir to coat. Let hash cook, stirring once or twice until crispy and browned in spots, and the sweet potatoes are soft enough to break in half easily when tested with a spatula, about 6 minutes.
Serve hot, or chill, and store in a resealable container up to 5 days. Reheat until steaming before serving.
This is definitely meal prep at it's finest, and I love all the seasonings too, so flavorful!
Thanks Kari! I appreciate the comment and the rating! And I'm so glad you love the flavors!
Excellent flavors and with the molten egg on top, pretty hard to resist!!
Tessa- thanks so much for the comment and rating! And I have to agree, it is so hard to resist! Glad you enjoy it!
I'm definitely adding this to my menu! I'm so bad at only baking sweet potatoes in oven, need to branch out there… haha.
Hey Raia! Thanks for the comment and rating! I guarantee trying sweet potatoes this way will have you completely sold on the idea!
I had this in the weekend and it was such a filling and tasty start to the day – and the fact that I had leftovers for the week was an added bonus!
Hope, I'm so glad you enjoyed it! It really is good leftover isn't it? Thanks for the comment and rating!
I love a good breakfast hash, and I love that you made it with sweet potatoes! Looks amazing.
Thanks Jean! I think you will love this- the sweet potatoes add a different flavor- you'll have to tell me what you think! Thanks for the comment and rating!
This is my kind of breakfast. It'll last me many hours!
It is one of those breakfasts that will keep you full and satisfied for sure! Thanks so much for taking the time to comment and rate!
This is one of my favorite breakfast for dinner recipes! I love this seasoning combo on sweet potatoes.
Trust me, I am fully on board for the breakfast for dinner idea! This one is a good one for that! Thanks so much for the comment and rating!
Consider my ears lent (is that a word?). I love anything sweet potato and never would have thought to use both smoked paprika and Italian seasoning. I am so definitely trying this for breakfast soon.
Hey, I totally knew what you meant, so I believe it's a word! Let me know what you think when you try out the seasonings together! Thanks so much for rating and commenting!
Love the smoked paprika! We love sweet potatoes for breakfast – it is so fueling! Thanks for the great breakfast recipe!
Thanks for the comment and rating! I agree that sweet potatoes for breakfast are the way to go- so delicious and will keep you going!
This will be perfect with eggs and a plate of bitter greens, tomorrow. Thanks. Love this recipe!


text:
Q: Copy S3 File to Docker Image via Dockerfile I have a Dockerfile that installs awscli and then tries to run aws s3 cp to get a file and put it on the docker image.
My dockerfile is:
FROM my-kie-server:latest

USER root
RUN echo "ip_resolve=4" >> /etc/yum.conf

ENV http_proxy host.docker.internal:9000
ENV https_proxy host.docker.internal:9000
ENV HTTP_PROXY host.docker.internal:9000
ENV HTTPS_PROXY host.docker.internal:9000

RUN yum install -y maven
RUN yum install -y awscli

USER jboss

ARG AWS_ACCESS_KEY_ID
ARG AWS_SECRET_ACCESS_KEY

RUN aws s3 cp s3://myBucket/myPath/myFile.jar x.jar

But when I build the image I get this error:

fatal error: [SSL: UNKNOWN_PROTOCOL] unknown protocol (_ssl.c:618)
  The command '/bin/sh -c aws s3 cp s3://myBucket/myPath/myFile.jar x.jar' returned a non-zero code: 1

I have tried using --no-verify-ssl on the aws s3 cp command but get the same error.
I've found very little online that mentions this UNKNOWN_PROTOCOL error. Any advice appreciated, thanks.


text:
News Roundup and Notes: May 21, 2015
by Ruchi Parekh
Daily News Roundup
Before the start of business, Just Security provides a curated summary of up-to-the-minute developments at home and abroad. Here's today's news.
IRAQ and SYRIA
ISIS militants are in full control of Palmyra, following the group's advancement into the ancient Syrian city yesterday, according to activists and a monitoring group. The fall of Palmyra could pave the way for the Islamic State to advance toward government-held areas of Homs and Damascus, reports Al Jazeera. The city is of strategic importance as it is situated among gas fields and a network of roads cutting across Syria's central desert, report Anne Barnard and Hwaida Saad. [New York Times] UNESCO has expressed deep concern at the risk posed to the civilian population and the celebrated World Heritage site. [UN News Centre]
More than half of Syria's territory is now under Islamic State control, a monitoring group has said. [Reuters]
Iraqi forces fought off a third Islamic State attack on the outskirts of Ramadi, which fell to the militant group on Sunday. [Reuters] The Iraqi government has waived restrictions on those coming into Baghdad, allowing civilians displaced by the situation in Anbar province to enter the capital. [BBC]
The U.S. is sending 1,000 antitank rockets to Iraq to assist forces in countering the suicide vehicle bombs deployed by the Islamic State in seizing Ramadi. [New York Times' Eric Schmitt] The U.S.-led coalition has also carried out airstrikes targeting Ramadi, according to administration officials. [Al Jazeera]
Administration efforts are now focused on Iraq's Anbar province, with the capture of Ramadi forcing a shift away from the planned offensive to reclaim Mosul in the country's north. [Wall Street Journal's Felicia Schwartz and Julian E. Barnes]
The loss of Ramadi highlights that ISIS is "still in business," despite Iraqi Prime Minister Haider al-Abadi's assurance that the "psychological battle" against the group had been won after the success in Tikrit, writes The Economist.
GOP senators sharply criticized the administration's strategy to counter the Islamic State in light of developments in Ramadi. [The Hill's Jordain Carney] And David Ignatius writes that interagency quarrelling is undermining the administration's efforts toward defeating the terrorist group. [Washington Post]
The Islamic State-affiliated group in Egypt called for attacks on judges in an audio recording from the leader of the group, Sinai Province; the recording's authenticity could not be verified. [Reuters' Michael Georgy and Stephen Kalin]
The UN has announced peace talks aimed at ending the Yemeni conflict; the consultations will begin on May 28 in Geneva. [UN News Centre] The leader of the Houthi rebel movement indicated yesterday that his group will participate in the UN-sponsored talks. [New York Times' Kareem Fahim]
The three-day Riyadh conference on Yemen ended with calls for the establishment of "safe zones," a joint Arab military force, and the delivery of greater humanitarian aid. [Asharq Al-Awsat's Nasser Al-Haqbani] Gamal Gasim analyzes the shortcomings of the Riyadh conference for Al Jazeera.
SURVEILLANCE, TECHNOLOGY, and PRIVACY
Sen. Rand Paul spent 10-and-a-half hours on the Senate floor attacking surveillance programs and key provisions of the Patriot Act, but it is unclear if his address yesterday had "real effect" on Senate Majority Leader Mitch McConnell's plans, report Seung Min Kim and Alex Byers. [Politico] Paul was joined in his efforts by ten senators, including seven Democrats and Ted Cruz; The Guardian's Tom McCarthy et al provide a comprehensive summary.
The NSA will need to wind down its bulk surveillance program after Friday, unless Congress agrees on legislation, in order to ensure the agency "does not engage in any unauthorized collection" beyond the June 1 deadline, according to a Justice Department memorandum. [Washington Post's Mike DeBonis and Ellen Nakashima]
Allowing key provisions of the Patriot Act to sunset would be a "big problem" for the FBI and the agency's ability to carry out its work, Director James Comey warned yesterday. [The Hill's Julian Hattem]
"BIN LADEN'S BOOKSHELF"
The ODNI released a trove of documents uncovered during the 2011 raid on Osama Bin Laden's compound on Wednesday.
The declassified documents reveal bin Laden's fixation with attacking U.S. targets, purported negotiations between al-Qaeda and allies within the Pakistani Taliban and Pakistani intelligence, and correspondence with the group's affiliate in Yemen. [Reuters' Mark Hosenball] One letter reveals that the al-Qaeda leader was contemplating leaving his Abbottabad compound in the months leading up to the U.S. raid. [Washington Post's Greg Miller and Julie Tate] The released materials also include, among other things, the contents of Bin Laden's library, correspondence with his family, and an application form to join the terror group. [The Guardian's Spencer Ackerman et al; Wall Street Journal's Damian Paletta]
A second U.S. marine has died after an Osprey aircraft had a landing mishap during routine training earlier this week in Hawaii. [Fox News]
The administration has no obligation to release the full version of the Senate Intelligence Committee report on the CIA's post-9/11 practices, a federal judge has ruled in response to a FOIA lawsuit brought by the ACLU. [Politico's Josh Gerstein]
President Obama described climate change as "an immediate risk to our national security," during an address at the Coast Guard Academy's graduation ceremony yesterday. [Al Jazeera America's Tom Kutsch]
French troops have killed four al-Qaeda jihadists in Mali, including two "terrorist chiefs," according to the defense ministry; one of those killed has been tied to the 2013 killing of two French journalists taken hostage in Mali. [France 24's Leela Jacinto]
Former Guantánamo detainees resettled in Uruguay ended their protest outside the American embassy in Montevideo, signing a deal with the Uruguayan government for housing and a stipend. [AP's Leonardo Haberkorn and Peter Prengaman]
A Moroccan man suspected of involvement in the Tunis attack in March on the Bardo National Museum has been arrested by Italian police. [AFP]
Iran's supreme leader ruled out interviews of Iranian scientists by international inspectors as well as inspection of military sites under any final nuclear accord with the P5+1, during a speech yesterday. [New York Times' Thomas Erdbrink and David E. Sanger]
Ukraine is building a nuclear missile shield, according to the country's top security official, who cited the need to "defend against aggression from Russia." [Washington Post's Karoun Demirjian]
Sen. John McCain is moving to significantly alter the oversight regime for acquiring new weapons, aimed at reining in officials and contractors and giving the military branches greater control over their own programs, report Austin Wright and Leigh Munsil. [Politico]
American soldiers and Pentagon employees improperly used military cards, spending over $1 million in casinos and "adult entertainment establishments" in one year, according to a new report from the Pentagon's Inspector General. [Washington Post's Dan Lamothe]
The U.S. and Tunisia are keen to "forge an enduring partnership," including deeper security cooperation, as outlined in a joint op-ed from President Obama and Tunisian President Béji Caïd Essebsi. [Washington Post]
The U.S. needs to offer "more than just rhetoric" to halt South Sudan's "downward spiral," writes the Washington Post editorial board.
Cuba and the U.S. will resume talks today aimed at reinstating diplomatic relations and securing the "crucial next step" of opening embassies, reports Reuters.
The Chinese navy issued eight warnings to a U.S. surveillance plane yesterday which was flying over islands in the South China Sea. [CNN's Jim Sciutto]
North Korea claims to be able to build small nuclear warheads to attach on to a missile, although analysts are unable to assess whether the country's nuclear program has advanced to this extent. [BBC]
Countering violent extremism. Join former senior UN counterterrorism official, Richard Barrett, and Just Security's Faiza Patel for a discussion on countering violent extremism on May 29, 2015. Details here.
If you want to receive your news directly to your inbox, sign up here for the Just Security Early Edition. For the latest information from Just Security, follow us on Twitter (@just_security) and join the conversation on Facebook. To submit news articles and notes for inclusion in our daily post, please email us at news@justsecurity.org. Don't forget to visit The Pipeline for a preview of upcoming events and blog posts on U.S. national security.
Ruchi Parekh
Former Associate Editor at Just Security
Follow her on Twitter (@RParekh88).
Early Edition: January 26, 2023
by Emma Snell