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Plantae Presents Panel: Evo-devo as a discovery tool
October 28, 2020 /in Blog, Plantae Presents, Research Skills /by Mary Williams
Plantae Presents – Evo-devo. What can we learn from comparative studies?
Recorded Wednesday, October 28 – 10 am EDT
We're pleased to announce the second in our series of webinars that are drawn from contributed short videos, followed by a panel discussion. This week we'll look at the topic of evolutionary development, featuring scientists from Missouri, Argentina, Chile, and India, and moderated by Javier Moreno.
Laura Saavedra: Roles of autophagy in growth and development in the moss P. patens
Laura Saavedra was born in Uruguay where she did her Master studies in Plant Molecular Biology at Universidad de la República. She obtained her PhD degree at Lund University, Sweden, at Prof. Marianne Sommarin´s lab working with phosphoinositide signaling and tip growth in Physcomitrium patens. Within the same line of research, she moved to Portugal as a postdoctoral fellow at Prof. Rui Malho´s lab at Universidade de Lisboa. In 2015 she joined Prof. Ramiro Lascano´s group in Cordoba, Argentina and since 2018 she has a Research position from the National Scientific and Technical Research Council (CONICET). Her current research interests are focussed on autophagy and phosphoinositide signaling linked to growth and development in bryophytes.
Yunqing Yu: The morphological diversity and underlying genetics of abscission zones in grasses
Yunqing Yu is a research scientist in Dr. Toby Kellogg's lab at the Donald Danforth Plant Science Center. She also has served as an Assistant Features Editor with Plant Physiology since 2018. She is interested in studying the molecular mechanisms underlying plant diversity and evolution. In Dr. Kellogg's lab, she is leading a project studying the genetic basis of abscission zone development in grasses, as well as using a combination of molecular, genetics, microscopy, and informatics techniques to understand the underlying mechanisms controlling seed shattering in various grass species.
Francisca Diaz: Present and past relations between plant diversity and climate change in the Atacama Desert
Francisca is a Chilean researcher now working as a postdoc in Rodrigo Gutierrez laboratory at the Pontificia Universidad Católica de Chile. She did her PhD in Ecology, specifically working in paleoecology. Francisca is interested in understanding the relationship between plant distributions and present and past climate in the Atacama desert. During her postdoc, she started to use environmental DNA to recover hidden plant diversity, and then she went to New Zealand to learn how to extract ancient DNA from Atacama plant old remains.
Kumud Saini and Aditi Dwivedi: Transcriptional landscape in a changing environment across evolutionarily diverged plant species
Kumud Saini has a PhD in Plant Biology from the University of Antwerp, Belgium, where her work focussed on auxin regulation of leaf growth and development in Arabidopsis. She has a master's degree in Plant biology and biotechnology from the University of Hyderabad and a bachelor's from Delhi University. Currently, she is a post-doc in the lab of Dr. Aashish Ranjan at NIPGR, New Delhi, where she focuses on 1) integrating environmental cues to developmental signals, 2) deciphering conserved molecular networks in diverse plant species, and 3) studying the impact of high ambient temperature on leaf initiation and growth at the cellular and molecular level. Her interest lies in studying plant adaptations to high temperatures using physiological approaches and through cell-specific transcriptome and translatome studies. Other than research she likes to spend her time on science illustrations and making oil paintings.
Aditi Dwivedi, a PhD student in the lab of Dr. Aashish Ranjan at National Institute of Plant Genome Research (NIPGR) New Delhi, is fascinated by plant developmental responses under changing environmental conditions. She obtained her Masters in Plant Biotechnology from Sam Higginbottom University of Agriculture, Technology, and Sciences. She developed an interest in environmental signaling in plants during her dissertation at National Botanical Research Institute, Lucknow. Her PhD work primarily focuses on comparative investigation of plant developmental changes under changing light and temperature conditions for phylogenetically different plant species using transcriptomics and gene regulatory networks. She aims to use the knowledge gained from her research to develop climate-smart crop plants.
Moderated by Javier Moreno
Javier studies plant-herbivore interaction and associated transcription factors controlling the plant-inducible response in Arabidopsis and Marchantia polymorpha. He is currently a Researcher (CONICET) and Adjunct Professor at the National University of Litoral in Argentina. He was a visiting researcher at Michigan State University (USA) and is currently an Associate Feature Editors at Plant Physiology.
This webinar is freely available thanks to the support of the American Society of Plant Biologists. Join Today.
Tags: Autophagy, Climate Change, Evo-devo
A plant-specific protein, COST1, mediates autophagy to promote drought tolerance (PNAS)
Viral proteins activate autophagy
Community diversity outweighs effect of warming on plant colonization ($) (Global Change Biol.)
Expression analyses in Ginkgo biloba provide new insights into the evolution and development of the seed (Sci. Reports)
Review: Gemma cup and gemma development in Marchantia polymorpha (New Phytol.)
Review: Convergent evolution of gene regulatory networks underlying plant adaptations (Plant Cell Environ.)
Persulfidation of ATG4 negatively regulates autophagy
Alpine plant growth and reproduction dynamics in a warmer world (New Phytol.)
Recognizing Plant Cell authors: Ronghuan Ji
Recognizing Plant Physiology authors: John J. Spiekerman


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beautiful! i love the pattern and the background!
Love the colours! So bold and pretty, and perfectly matches the red bag, too!
The clean, smart lines allow her to carry off such a fabulously interesting pattern. Very cool indeed.
love the color and prints!!
Wow! Love the color and the print. And her bag.
i love her style… wish i had the money to buy all her clothes.
is springtime arrived? ehm in italy is still cold, biut the look is perfect! Ottimo GIovanna!
This print is beautiful, plus I love her expression! Its impressive that she manages to pull off double sleeves with so much elegance..
Giovanna has such an impeccable style, above all love this grey patent shoes.
Unafraid of color!! The way life should be.
love it! she looks so sophisticated!
loving the fresh colours! Spring, finally!
what an incredible print that she is wearing! i love it.
Lovely as usual, but the skirt needs to be 3-4 inches longer to achieve the right line.
this woman is like a poem!
I love her outfit, is it silk? She always manages to look perfectly turned out with so little effort. I like her hair, just long and straight.
The light from a grey day is so delicate and makes the colours of her ensemble stand out beautifully.
Not one of her better outfits. Nothing seems to match.
Beautiful and creative as always!
perfect mixture of winter and spring!
So many different colours! Green with brown, black and grey… but it's a good match!
perfect mixture of spring and winter!
ah, I've been waiting to see pictures of her…Thanks Scott!
does anyone recognize the designer of her suit?
Love the pop of color from her suit against the gray background.
Showstopper!! Just perfect with the bag.
Love the bag! Is it Celine??
can you just follow her around?! lol she's great, one of my favorite women to look at, she always looks great, no matter what.
love it. all of it.
What a beautiful and sophisticated outfit-the color palette and the print are quite exquisite. Her heels are darling too.
She really gets it right, in my opinion, anytime you post photos of her.
I love Giovanna's style. This entire look is great. I'm really loving how her hair is framing her face, and that bag is great too!
I have just never been much of a print fan myself. Kudos to those who can pull of all the bold prints and patterns, though.
I am a woman and I simply LOVE Giovanna. E bellissima! I just cannot understand what is she doing with that Roitfeld boy… Such a mismatch!! He doesn't deserve her in the tiniest bit!!!
This lady always looks beyond fantastic anywhere, anytime – and it looks so easy – like she just woke up and fell out of bed dressed and the perfect accessories attach themselves where they belong. Magic!
I can't never get enough of Giovanna. My favorite, yes!
J'adore le concept du tailleur par dessus un pull noir. Et elle porte le sac de mes rêves…: que dire de plus ? I LOVE IT !
Love that shoes! And the shoot!!
Giovanna never fails to inspire us with amazing outfits. I love her style and her grace. What a beautiful shot!
Great bold print on the skirt suit.
My favorite fashionista. She is so Italian yet I like how her cosmetics are always understated.
She's the best! Giovanna, sei meravigliosa. Baci.
Hope to hear your thoughts on my blog.
LOVE the purple pants and the black beaded gown!!!
Love ur blog every day more than the first ! beautiful photos! u rock!
This is a very elegant woman…..cheekbones like a queen! But while the outfit may be striking, I guess it must be a very urban interpretation of spring. The colors of the print look hard, cold and glaring. They go with concrete, not of nature, and distract from her innate beauty.
Picture her in all off-white or all black or just about anything else…..immediate improvement!
She looks gorgeous, love those colours, it makes such a bold statement!
I'm in love with the print on the black background! Beautiful and genius.
I'm thinking of insisting that my name always be followed by an exclamation point. Why not?
Shoulders back!!! Spindly heels leave one vulnerable to the sparrow hawk look if one is not careful. Cheery fabric.
I think she just persuaded me to wear patterns, though I hate patterns usually. This is amazing.
The clothes is so adorable.. I just don't think she has the right shoes with it.. since the black stockies are not good for the shoe color.
Love the jacket, but dang, that's a mighty short skirt.
What can I say? Those tights and those shoes just don't go together.
WOW… that pattern and teh colors are amazing!! Love it!
She looks like the first buds of spring in that chic green outfit!
love the colors on her outfit.
Once again she reminds me of a graceful Modigliani woman that's leapt off the canvas. I'd never think to layer a black turtleneck and tights under such a ladylike suit but it instantly makes the suit modern rather than frowzy.
I lvoe this green aptterna nd the Fendi bag, so cool!
Lovely style! I like her 2 piece set.
Le sigh, stunning as usual.
The woman can do no wrong.
Her posture here is terrible. Not a big fan of the outfit either, but I am loving the watch.
Ah, Giovanna! You kill me all the time!!!
A cool way to wear a suit!!
I think she needs to lose the bag entirely.
I know she usually looks great, but I don't like this so much. I agree with someone else who said the proportions aren't quite right, and the fit – the skirt is bunching in the front, and I don't think the cut of the jacket is that flattering. But it's always interesting to see what Giovanna is wearing anyway.
Thumbs up … I know the feeling, love the vivid colors, and like the look. Wearing this gives winter a hard bright push out the door. It's like a florist forcing bulbs to flower. At the same time the wearer doesn't look naked or cold.
I just love how the bag and purse and print and the tights are not perfect matches, and that makes it all look so much more fantastic and unexpected and interesting.
Oh my God! She's carrying the Fendi bag I'm dying to own. I'm pea green with envy!
She is one beautiful dame.
love that print and the retro bag and the fact its styled in such a modern way with black opaques and heels……..
she's always perfect..but she seems 40 and she never smile….
Perfect look. The pattern and cut is outta here!
Bella!! The shoes are so gorgeous, they give the whole look an edge. Her hair's great too – hair envy!
The shoes and her bag! My word!
Yikes! Giovanna is usually right on, but this outfit is a miss for me. Not crazy about the cut or drape of the suit, and its shortcomings are amplified by the overall black back-drop. Dark-brown or very deep burgundy tights and scrunched opera-length gloves (especially in a light-blue color) instead of the long black sleeves would have been a better choice. Love everything about the shoes but the color — doesn't work with that outfit and the bag.
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Can Acupuncture Lower Your Blood Pressure?
Home Cardiac Medication and Treatments Can Acupuncture Lower Your Blood Pressure?
Not so long ago, acupuncturists were viewed as little more than snake oil salesmen.
No one was doing any research on acupuncture, because mainstream medicine refused to admit that it had any basis in reality. Nevermind that the Chinese have been treating disease with acupuncture for thousands of years — successfully, I might add. Because it doesn't conform to our narrow Western views, stories about acupuncture were dismissed without even listening to them.
Will it make me feel better?
Does it have unpleasant or dangerous side effects?
Will it cost me an arm and a leg?
The answers are yes, no, and no. So in spite of Big Medicine's efforts to stamp it out, acupuncture has slowly but surely gained a foothold in the field of health and wellness. Even the scientific world is beginning to take notice.
We have 20 years' worth of evidence. Why is this not standard treatment?
People have been studying the effectiveness of acupuncture for years. Interest really picked up in the late 80s and early 90s, and today there's a large body of research.The results are nearly always positive — but somehow they never seem to make waves. Every few months somebody publishes a study showing that acupuncture lowers blood pressure. It's headline news for a couple of days…then we never hear about it again.
"Acupuncture Can Lower High Blood Pressure," WebMD declared clear back in 2001. The article — just one of dozens from the early 2000s showing that acupuncture works — went a step further than most. "Scientists investigating its actions in heart disease have found not only that acupuncture works," it said, "but why and how."
The same website published an article this month declaring, "Acupuncture Might Help Ease High Blood Pressure." Then they go on to say don't get excited, it's only a small study. It's "not conclusive".
But wait! Back in 2001, researchers were describing how and why acupuncture works for high blood pressure. They were talking about it becoming a standard treatment. Yet today they're giving us the same old, "Wait, we need more research" line. What happened?
Big Medicine and Big Pharma have a great strategy for dealing with "alternative" medicine. It's a four-step plan. First they try to scare us out of using it. If that doesn't work, they co-opt it — maybe they start doing the treatment themselves and pass rules to stop anyone else who isn't a doctor. Or maybe Big Pharma changes one molecule of an herbal remedy, then patents it and calls it a drug. This kind of thing happens all the time.
If they can't do either of these things, they try to ban it. This comes up each year with supplements. Every year Congress floats a bill to call them drugs or outlaw them altogether, and each year it fails.
And if all these strategies fail, they have one last option: they simply ignore what's going on.
They refuse to talk about it. They refuse to research promising treatments. And if anyone is dumb enough to do some research anyway, it either gets buried or it gets ridiculed. In any case, it never gets the chance to catch on with the average person.
Because let's face it: you and I care about our health, and probably most people do too. But too many people still believe the lie that Big Medicine has our best interest at heart, and that Big Pharma wants to make us well. So most people, if they hear about alternatives like acupuncture at all, shrug and go on if their uninformed doctor tells them it's a load of hooey.
This is a far more effective strategy for the Big Guys than banning things outright. And this is what's happened with acupuncture.
Big Medicine can't take it over — it takes years of special training to become an acupuncturist.
They can't scare us out of using it — there are no possible side effects to point to, and no outlandish cost to get righteously indignant about. They can't ban it for the same reasons. So they have no choice but to ignore it and hope it goes away. Because for every one of us who lowers our blood pressure without pricey office visits and a prescription in our hand for life, Big Medicine and Big Pharma lose Big Money.
Choose a licensed acupuncturist. While acupuncturists in all states must be licensed, there are some other health professionals, such as chiropractors, who are allowed to do "needle-less acupuncture." It uses weak electricity rather than needles.
This treatment has its place. However, acupuncture is just one aspect of a whole alternative medical system — Traditional Chinese Medicine — and other health professionals just aren't going to have the training and background that a licensed acupuncturist does.
Ask what his or her specialty is. Many acupuncturists, just like other health practitioners, have special areas of focus.
Research before you make an appointment. Check out their website. Talk to other patients if you can. What kind of reputation do they have? Are people satisfied with their treatment?
Choose someone you have a rapport with. Medicine — whether mainstream or alternative — is as much art as science, and acupuncture is especially so. Choose a practitioner who makes you feel comfortable.
See if your insurance covers treatments. A few plans do.
Let your M.D. know what you're doing — but don't be discouraged if they act like you're a little nuts. Doctors have mixed opinions about acupuncture. Some think it works, some think it's quackery. Regardless of their opinion, if you're taking blood pressure meds you may need your dosage adjusted as the acupuncture does its work.
Some studies show the effects of acupuncture on blood pressure can last weeks or even months for some people. However, it may not be a quick fix — each person is different, and while for some a single monthly session may do the trick, for others it may take a series of treatments to get to an acceptable level.


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Margaret Lindsay
Margaret Lindsay (born Margaret Kies) was an American film actress. Her time as a Warner Bros. contract player during the 1930s was particularly productive. She was noted for her supporting work in successful films of the 1930s and 1940s such as Jezebel (1938) and Scarlet Street (1945) and her leading roles in lower-budgeted B movie films such as the Ellery Queen series at Columbia in the early 1940s. Critics regard her portrayal of Nathaniel Hawthorne's Hepzibah Pyncheon in the 1940 film adaptation of The House of the Seven Gables as Lindsay's standout career role.

redpajama_set_name: RedPajamaCommonCrawl


This improvisatorial part is the second half which the tune was going up most. ( maybe ), The cacophony of the better piano of tuning is happily more beautiful. The "wonderful" reverberation in which sound comes down from on the head occasionally with rich sound like a full concert ground is comfortable.
If it passes over bisection from a performance start, the Bösendorfer made from 1939 will change to my finger, and will begin to riot. It begins to run about at full speed. Sound completes and goes at the moment to uneasy inside occasionally like a terrible storm at a moment.
Soon, a storm goes away, and moves and goes to the following scenery.
Improvisatorial without a musical score is transitory. An Movie "fixes" improvisatorial.
By the improvisatorial music which advances and goes while reacting to an instantaneous sound at the moment, there is always danger of damping. It is difficult to consider the whole composition and to clarify introduction development turn and conclusion.
I am poor at performing improvisatorial, looking at a clock. Furthermore, having been troubled has a certain study group at the same place on the day, and it has encountered the friend of a place of work in a body. The motto which does not bring work to music and which does not carry music into work is full collapse.
My wife by whom the only help rarely comes to hear my piano commented only this portion "was good." This is a very new thing.
Since description of this performance is explained by the blog of my friend with literary talent.
Color changes in a dazzling spectacle. Damaged Bösendorfer Restoration Concert August 2, 2014.
This performance is an improvisation in the Damaged Bösendorfer restoration concert by which it was hit by the earthquake disaster held in the Takasaki-shi, Gumma synthesis welfare egg hole on August 2, 2014. I talked with this piano for the first time in three years.
One after another, color scenery changes only to it being dazzling, and goes as the piano is speaking something. Although the piano had entitled an unstable sound at first, gradually, the dazzling world of rich color is drawn talkatively, and it goes.
Usually, improvisation comes out only in the range of the technology which self has, and the music which self experienced. If self-analysis of this performance is conducted, a destination exists two to three times to one code. So to speak, it is " chord play" improvisation. A key's converging one on D and another are becoming a triple measure unawares, even if it begins by quadruple measure. This is not conscious of this during a performance.
Eyes, an ear, and a finger carry out shortcut when I am improvising, and I do not consider at all. Is it made into Bechstein whether for me to use a Bösendorfer conversation with Bechstein for 14 minutes, it was wavering.
However, I listened to the performance of a rich feeling of color of Debussy of Mr. E of the 3 public, and chose Bechstein.
Although it was slightly redundant, it unites with a piano and I fall into a cartridge or the feeling carried out. A fingertip reacts to Bechstein's bright tone and sound is spelled in the state where the head is almost empty. It seems that the old woman of past these 90 years old likes "an easy bright color." This improvisation became contrastive [ the sport-combative system improvisatorial with another Bösendorferr which I flipped ] these two weeks ago.
If a piano changes, improvisatorial will change 180 degrees.
Schedule performance time was exceeded for 2 minutes.


We have loads of great wildlife events for adults, kids and families in Somerset. Hopefully the list below will give you lots of ideas for things to do, and give you more information about the interesting and fun activities you can take part in. Take a look at what's on below.
Because some of our events and things to do are held in the wilds of Somerset they include a grid reference as a meeting point - post codes are too imprecise. To see the location for the activity on a map go to Street Map and type in the grid reference (e.g. ST456437 no spaces.) If you zoom out you will first see the OS Explorer and Landranger maps which have more detail and then larger scale maps. Go to Street Map now.
John Bebbington FRPS, who was Somerset county moth recorder until the end of 2018, will give a talk on Somerset Moths. He will cover both the common and rarer, lost and newly arrived species, threats to our declining moth populations and what we can do to encourage moths.
Roger Dickey will lead a 3km walk from Langport, out along the old railway line and back along the bank of the River Parrett, looking and listening for early migrant birds. Binoculars will be useful.
Practice your bird and wildflower identification skills on a walk through SWT's Harridge Wood Nature Reserve with professional ecologist and wildlife enthusiast Eve Tigwell.
Somerset Wildlife Trust Somerset's Brilliant Coast team would like to invite residents and friends of Otterhampton, Combwich, Stockland Bristol and Steart to an informal meeting to talk about the important coastal habitats and natural history in and around the Parishes.
Somerset Wildlife Trust has funding to support exciting new community projects which enable local people connect to their coastline, to encourage health and well-being and to help protect nature for future generations. We need your ideas and enthusiasm! Come along to find out more about how to get involved and to help design the project. FREE TEA & CAKE PROVIDED.
A walk through country lanes with Medical Herbalist Bett Partridge.
Join Valerie & John Godsmark for a coffee morning followed by a guided walk focussing on ancient woodland Spring flowers at Park Wood LWS and Private Nature Reserve.
This year's South East Area Group's Annual Plant Sale will be part of the 'Eat Cary Festival'.
Join Chris Holland from WholeLand as he takes us on a fascinating and tasty coastal foraging adventure on Brean Down and the beach.
Plastic Free Minehead and West Somerset Together are organising a Beach Clean at Blue Anchor. The clean will start at 11am and end about 1pm. After the clean we will gather to sort the litter that has been collected. This event is part the campaign to get Minehead and West Somerset recognised as a Surfers Against Sewage Plastic Free Community.
Bring your family along to Brean Down to enjoy a delicious foraged feast on the beach. Families will have the chance to take part in a playful and tasty coastal foraging adventure led by experienced nature based educator Chris Holland from WholeLand.


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Marco Wittmann test drives a Scuderia Toro Rosso F1 race car
Home » Racing » Marco Wittmann test drives a Scuderia Toro Rosso F1 race car
A childhood dream is set to come true for Marco Wittmann: the reigning DTM champion is being given the opportunity to sit behind the wheel of a Formula One car for the first time in his career. During the official tests at the Red Bull Ring on 24th June, Wittmann will take to the track in Spielberg in a Scuderia Toro Rosso car, the 2015 STR10.
BMW Motorsport was able to arrange this special Formula One test thanks to its excellent relationship with premium partner Red Bull. The drive in the STR10 is BMW Motorsport's a way of rewarding Wittmann for the extraordinary performances he produced throughout the 2014 DTM season, which he crowned by winning the Drivers' Championship.
The Formula One test was just one of the surprises bestowed upon the newly-crowned champion by BMW Motorsport Director Jens Marquardt at the final race of last season in Hockenheim. For his achievements, Wittmann was also honoured by launching the limited BMW M4 DTM Champion Edition.
"It is fantastic that BMW Motorsport and Red Bull are giving me this opportunity to take part in the test," said Wittmann. "This is a dream come true for me. As a child, I always wanted to drive a Formula One car. I am sure it will be a very special experience to drive the STR10. After many successful races in my BMW DTM racing car, I am excited about getting back in a single-seater car for a brief outing – especially such a fantastic car as that of Scuderia Toro Rosso. Above all, I am excited about an even higher top speed, the acceleration, braking later, and the g-force."
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According to the United States Geological Survey, there was a magnitude 4.1 earthquake at 4:47 p.m. centered 10km ENE of Dover, DE. The quake was felt up and down the I-95 corridor from Washington, DC to New York City. More information can be found at USGS.gov. The last memorable quake in the Philadelphia area happened back in August 2011, although smaller ones do happen from time to time.
Philadelphia Police have released more details about the body of a girl found in a lot behind a building in West Philadelphia on Tuesday morning. 15-year-old Sabriya McLean was found in the 200 block of South 49th Street. She had been stabbed around 80 times and her body had been set on fire. The suspect, 23-year-old Cole Swaringer-Herring, lives nearby in an apartment with his parents. He told them he had killed someone and then took police to the body. McLean met Swaringer-Herring over Facebook and the two met in person on Monday night. She is from New Castle, Delaware, and had been reported missing. She turned 15 back in October. In February 2014, McLean was also reported missing and found at a friend's house on the 4700 block of Sansom Street. She was 11 at the time.
A man in Charlotte, NC is suing Philadelphia Eagles defensive lineman Fletcher Cox for seducing his wife. Joshua Jeffords of Huntersville has filed the suit against Cox for alienation of affection. Jeffords claims to have discovered text messages and Snapchats between Cox and his wife that include explicit photos and discussions of having children together. Jeffords says that his wife met Cox when she went to Pennsylvania on a work trip in April. He is seeking $50,000 in damages for "substantial emotional distress."


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Rashmi Suresh Patil believes that if given a chance, disabled people can prove themselves
Get-hooked July 23, 2020
23-year-old Rashmi Suresh Patil from Mumbai was diagnosed with hearing impairment when she was hardly one year old. Rashmi's path to empowerment is inspiring as she has crossed many hurdles. Rashmi, who is a dancer and model, is currently pursuing a course in Nitya Yoga.
Nothing is impossible for 23-year-old Rashmi Suresh Patil from Mumbai who was diagnosed with a hearing impairment. A dancer, model and cook, Rashmi juggles roles with ease. She has all the support from her family comprising of parents and younger brother Jatin who has autism. Together, they are a team that believes in overcoming any obstacles ahead of them. After all these years, Rashmi has learnt to make the best out of life.
Diagnosis of a hearing impairment
Rashmi's mother Archana Suresh Patil is her strongest pillar of support. Archana has always stood by both her children to ensure that they get nothing lesser than the best. Being the eldest child, Archana and Suresh excitedly welcomed Rashmi to their lives. It was when she was around eight months old that Archana started noticing how Rashmi did not respond to sounds.
Once, there was a huge noise near our house and Rashmi did not respond to that. She was asleep, so I had my doubts. But I did not want to think of the worst because there was no children with disability in our family. We took her to an ENT specialist who said that some children might take time to respond to sounds. It was soon after her first birthday that we diagnosed her with a hearing impairment- Archana Patil, Rashmi's mother.
By the age of two, Rashmi started wearing hearing aids. She was able to lip read and hence learnt to speak, thanks to her two years training at the Central School for the Deaf in Mumbai.
Rashmi was in a regular school since class 1, though she did have some difficulties coping up with other children and teachers who were unaware about inclusion in schools. But Archana was determined to help both her children with disabilities. She completed a parent guidance course that helped her work along with Rashmi and Jatin. "I did not have to take them to therapists because I could reach out and help them after completion of the course", she says.
Path to empowerment
Rashmi had attempted to pursue a degree course, but had to discontinue in between due to certain health conditions. So she is currently pursuing her diploma in Nritya Yoga from an open university. Her exams have been postponed due to the Coronavirus crisis and lockdown.
Archana remembers that Rashmi loved dancing since a very young age. In spite of a hearing impairment, moving to dance steps gave her immense joy. Her parents introduced her to dance and this youngster has even won a national level championship! Rashmi also completed six dance exams with distinction and did an advanced course for two years as well. Rashmi has also been teaching dance at her institute.
She was invited as a guest to the 'All India Artists Association' annual event in Shimla last year. In years to come, Rashmi hopes to concentrate on dance and even build a career in it.
Her tryst with modelling began a couple of years ago. Rashmi has participated in three beauty pageants and brought home laurels too.
This youngster who is in love with cooking has been experimenting with dishes during the lockdown period. Her mother says that the entire family fell in love with her unique delicacies. Moreover, Rashmi manages all the household work too.
She has also been making hand-made jewelry since the past five years and has clients from across the globe.
Archana believes in giving her children opportunities. "I was always sure that they will come out in flying colors and they did", she says. For Rashmi, a determination is what matters the most. "Given a chance, we can prove ourselves", she says.
https://youtu.be/A2NQika9NZ
Partially deaf photographer Rajen Nair promotes artwork by disabled kids on social media
Understanding Stimming
#BeingMom - What makes Nalini Srivastava such a power mom?
Understanding Art Therapy For Autism
#WonderWoman - Ketna Mehta is giving people with disabilities wings to fly


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Lyumjev – a fully closed loop case study with oref1
14/10/2020 admin Lyumjev, oref1, Ultra-Rapid Insulin 6
When Lyumjev, or URLi was announced, and pharmacodynamic details released back in September 2019, I noted that it had the potential to transform the use of oref1 and make it potentially feasible to use a system running this algorithm without any form of meal announcement. You'd simply be able to eat and ignore, which is the ideal of the artificial pancreas. It had the potential to transform oref1 based DIY APS solutions into beyond full stage 5 artificial pancreases, as per the JDRF suggestion. It wouldn't be multihormone, but it would allow there to be not only no need to bolus for meals, but also no need to even announce them. A stage 5.5 if you like.
Since the arrival of Lyumjev in Europe, a number of users of AndroidAPS have been trialling using it and seeing what their outcomes are. As readers of this site will be aware, unfortunately it doesn't seem to work for me, however for others it is far more successful. As a result, this is the translation of a paper published by one of our community in Germany, outlining their experience and the outcomes comparing a Fiasp/Novolog mix, Lyumjev as a hybrid closed loop and finally Lyumjev in a fully closed loop.
The results are remarkable and leave a lot of open questions for both commercial systems and those who are working in research in this area. Suffice to say that the results when operating a fully closed loop for this n=1 study were a time in range (3.9-10mmol/l/70-180mg/dl) of 97% and a standard deviation of 23.1%. It's worth bearing in mind that the starting point for this user was 94% TIR.
For some DIY users, it looks like the future is already here!
The paper is below, and can be downloaded here: Lyumjev_w.UAM-week_Be_13Oct20.
Improved Outcomes and Ease-of-Use when closed looping with Lyumjev
A new ultra-rapid insulin (Lyumjev, Eli Lilly, USA) might offer advantages for looping over currently used insulins like Fiasp, Novorapid (Novo, Denmark) or Humalog (Eli Lilly, USA). This is a (n=1) pilot study investigating the outcomes when switching to the new insulin in a closed loop.
Closed Loop with AndroidAPS 2.6.1 using the oref(1) algorithm with "SMB always" setting, the Accu-Chek Combo insulin pump (Roche, Germany) and Dexcom G6 CGM using factory calibration code (Dexcom, USA).
Trial period was 1 week in each of three modes:
(A) Looping with 50/50 mix of Fiasp/Novorapid (both: Novo, Denmark), in a mode that the user had thoroughly "tuned" by adjusting factors and settings for good performance over a period of many months.
The same settings as in (A) were used in AndroidAPS for (B) and (C), except for entering the shorter time-to-peak for the new insulin (45 minutes), and shorter DIA (5 hours):.
(B) Lyumjev (Eli Lilly, USA) was used for standard looping as in (A)
(C) Lyumjev (Eli Lilly, USA) was used in a totally different mode of looping called UAM (unannounced meals). Here, the user does not make any inputs about carbohydrates, nor is he/she doing any bolusing. The max. allowed size of a SMB was elevated from 90 to 120 minutes basal for this mode.
Especially in (C) it was important to use a smoothly performing CGM system. It was monitored for values eventually getting "jumpy", and values were checked at least daily against a blood glucose measurement, to determine eventual need for a new sensor.
The study was done by a male person in the age group 60-70 who is retired, has normal body weight, and has a moderately active lifestyle (biking and walking regularly with his big dog, garden work). He has been on pump therapy for nearly 20 years, and on AndroidAPS closed loop for 2 years and 3 months. TDD 37 U, and basal 13 U/d. Time in range (70-180 mg/dl) in 3 months prior to this study was 93% (with 1% under 70 mg/dl), and recent laboratory HbA1c was 5.8%.
Daily caloric intake around 2200 kcal came from 165g carbs, 85g protein, 90 g fat and 40 g alcohol. Lunch was the main meal; very minor breakfast. In all investigated modes, meal management involved pressing EatingSoonTT one hour before meals. (This sets a low temporary glucose target).
In (A) and (B) a bolus was given for max.60g carbs. Later absorbed carbs , also from FPU, were announced via numeric input into AndroidAPS, including the estimated absorption time window.
In (C) no carb inputs were made, and also no boli were done by the user.
Autosense was used in the range 0.6 to 1.5. In all three studied modes, a user-defined "automation" was implemented which (in case of AS<130%) elevates profile to 130% if glucose rises above 170 mg/dl.
The study data were evaluated as 7 day statistics in the xDrip+ software (V.2020-09-04) which every 5 minutes captures the "native" glucose values from the Dexcom CGM transmitter, and sends them into the AndroidAPS looping software. Results were cross-checked using the statistics section of the AndroidAPS software (V. 2.6.1).
Chart 1, A-C shows the results from 7 days each of closed looping in modes:
(A) Fiasp/Novorapid "tuned"looping (B) Lyumjev @ standard looping (C) Lyumjev @ UAM
Chart 1-A
Chart 1-B
Chart 1-C
Lyumjev usage(B) reduced highs by 66% (70->24) and lows by 55% (42 -> 19).
In a usage mode without any carb inputs or user-triggered boli (C), highs were reduced by 39% (70->43) and lows by 88% (42 -> 5)
TIR (70-180 mg/dl) improved with Lyumjev from 94% (A) to 97% (B and C).
Chart 2 A-C shows the scatter of glucose values by time of day, for 7 days each (10-90% of all value are in the dark-blue areas; 25-75% light-blue; mean white. Colored lines = 70 resp. 180 mg/dl range limits.). In the UAM mode increased scatter is seen after the main meal (lunch), with values exceeding 180 mg/dl up to about 200 mg/dl for the 90% dark-blue mark.
This also results in slightly higher mean and median value, higher Std.Dev., and higher HbA1c in the pure UAM mode (C), compared to Lyumjev standard looping (B). Also, only marginal improvements are seen with (C) when compared to (A), regarding these metrics (chart 1).
In the UAM mode, the lowest incidence of low values under 70 mg/dl was found (5 compared to 42 in mode (A), and 19 in mode (B); chart 1). This finding contributes to the UAM mode (C) receiving a PGS rating of 4.16 which is comparable to the 3.81 value found in mode (B).
Site reactions (hematoma) were seen in 1 of 4 cannula sites with Lyumjev in (B). No site reactions were observed in (A) or (C).
There is an indication that daily insulin requirement was reduced in the UAM mode with Lyumjev (chart 3: 34.81 U/d, compared to 37 U mean in (A) and (B)). However, this study was not thoroughly controlled for evaluating this aspect.
Charts 4 and 5 show how the TIR findings would change if applying a narrower range of 70-140 mg/dl.
1/98/1 in AAPS = 1/97/0 in xDrip+(diff.rounding)
In the first week on Lyumjev (B), 13% of values were above 140 mg/dl, and 14% were above this threshold in 30 days, which included the 7 days in mode (B).
In the week on Lyumjev in UAM mode (C), 20% of values were above 140 mg/dl (chart 5).
The observation period of only 14 days using Lyumjev in total allows only very cautious, preliminary conclusions. Hopefully, we quickly will see further investigations into the sketched very promising new modalities of looping.
Site reactions (hematoma) as seen in (B) were not observed in (C), probably because 1) cannula utilization was strictly limited to 48 hours and 2) in the UAM mode (C), never any big boli are released, but every 5 minutes some smaller amount (if any) is administered by the loop.
Because of low tolerance and a tendency towards occlusion due to hematoma the study participant was unable to use 100% Fiasp but diluted it with Novorapid. It could be hypothesized that using 100% Fiasp in( A) would narrow the relative advantage seen in this pilot study for Lyumjev.
Of note, mode (A) was what the patient had routinely used for a couple of months, with occasional attempts to optimize results by "tuning" factors and settings. There was no such attempt made to optimize any settings for looping with the new insulin. Therefore, also bigger advantages than those described here are imaginable.
This report has a problem in that – within the selected standard reporting range 70-180 mg/dl – there was not really much room for improvement, starting out from a 94% TIR in mode (A).
However, the results seem meaningful as it does become exponentially more difficult to reach improvements when going towards 100% TIR.
It remains to be seen, whether loopers with lower starting TIR also can find a comparable pattern to the one described in this report.
The movement towards target after midnight, to early morning (chart 2), works slightly better (with less scatter, at same ISF setting) with Lyumjev. The shorter DIA of the new insulin ( 5.0 h vs. 6.7 h for the 50/50 mix (A)) might contribute to that finding.
Regarding the effect on glucose curves, noon to midnight: This is after the two main meals, where in mode (B) the faster onset of active insulin seemed to help curb glucose rises. Likewise, we can expect faster corrections of high values, something to investigate in other studies where users might encounter values above 200 mg/dl more frequently.
In this pilot study no efforts were made to check diet-related limitations, notably in the new UAM mode (C). Further investigations are needed about the net glucose-elevating effects of deliberately consuming a big amount of rapidly digested carbohydrates. Also, no meals above 100 g carbs were included (although the latter would seem less of a challenge, as the physiological absorption seems to be limited around 30 g per hour, and the UAM algorithm might be able to keep up with that).
In the UAM mode (C), the algorithm cannot give any meal-related insulin before it sees the glucose rising. On top of the effects owed to glucose absorption physiology, there is the additional delay of a few minutes coming from the CGM system, which only can measure glucose in tissue but not in blood. Therefore, not unexpectedly, we see in the glucose curves in (C) more incline and scatter in post-meal hours. This is probably the prime reason behind the slightly higher average glucose and HbA1c in (C) compared to (B).
As a consequence, mode (C) performance in terms of TIR is also more dependent on the selected upper threshold, than modes (A) or (B) (chart 4-5). It could be argued that, as state of art progresses towards better glucose control, metrics based on the conventional definition of a 70-180 mg/dl range should be abandoned in favour of, for instance, 70 – 140 mg/dl. This would put the UAM method at a disadvantage: Due to the fact that no early bolusing before a glucose rise is possible in that mode, it needs a certain "wiggle room" around and also above 140 mg/dl . Advantages of UAM (C), compared to the other modes, will become visible more above 180 or 200 mg/dl, and highlight the differences focussed on an area of certainly more valid medical concerns.
The PGS is supposed to give a good overall medical assessment of each mode. Here we in fact see (chart 1), despite the difference in HbA1c, a similar evaluation of 4.16 in mode (C) and 3.81 in mode(B) , compared to 8.73 in mode (A).
The UAM mode can make up for some deficiencies in the upper-normal glucose range with the very small incidence of low values <70 (5 vs. 19 in (B) and 42 in (A)), chart 1). If the loop runs with well-adjusted factors, this finding really makes sense: In the two other modes, users can and will give boli with the potential of leading to low values (that the loop will try to counter, but it's capabilities cannot go beyond shutting off basal in so-called zero-temping). In mode (C), the algorithm just fights glucose rises, using the caution inherent in the algorithm.
Overall this pilot study shows the following pattern:
Using Lyumjev in a closed loop (B) improves TIR (70-180 mg/dl) and HbA1c. High and low glucose values are reduced. Of note, advantages are less prominent if a 140 ,mg/dl threshold is used instead of the 180 mg/dl standard.
Using Lyumjev in an UAM mode (C) undisputibly would bring a big relief in sharply reducing the daily mental burden (and often health hazards) associated with carb counting, determining size and timing of meal-related boli, and of correction boli. However, in the UAM mode only a small reduction of average glucose value and HbA1c was realized. The medical value of the UAM mode seems to lie rather in avoidance of low values, and is reflected in the excellent PGS rating achieved.
As expected, the most rapidly acting insulin offers potential for an improved outcome in terms of time in range, and lower average glucose.
Still, the UAM mode might disappoint patients who strive for HbA1c values well inside the range seen in healthy subjects, i.e. below 5.8%, even at a certain risk of hypoglycaemia (which they might consider manageable, as with CGM and loop they can be rapidly detected and nearly always averted). It remains to be seen whether some tuning of settings, or the advent of even faster insulins, could in the future bring further improvements.
Some daily user interaction will also remain in the UAM mode for setting temporary glucose targets before meals and before sports, but some of that could also be automated within AndroidAPS (which offers to formulate and activate user programmable automation routines).
In the end it comes down to a personal choice, which TIR is good enough, so it does not become an obsession to permanently "feed" and "tune" the loop.
When "good enough outcome" is achieved, not having to bother with meal inputs, boli, or even pre-boli any longer has been kind of everyone's dream. Based on this brief observation period, Lyumjev seems to be well suited for the fine regulation of the AndroidAPS loop, and should bring the UAM mode, which, among available solutions, closest resembles an artificial pancreas so far, into reach for more people with diabetes.
Closing remark
This paper does not constitute medical advice. Any attempts to use unregulated products like the open source software AndroidAPS, or to reproduce what seemed to work for another patient, would be on own risk. Speak to your doctor. Learn about the system before you use it. Do not test out the limits, like with a really big meal, before you saw your system work at moderate challenges. And always safeguard yourself by making use of the alarm options integrated in all open source systems, as well as in the commercially sold components of it.
Closing remark especially for users of iOS Loop and of commercial closed loops
The reported study was done using AndroidAPS which uses core OpenAPS algorithms. iOS Loop (and also most commercially available loop systems) differ significantly in their core algorithms, and rely much heavier on input about amount and kind of carbs consumed.
While all loopers are likely to gain benefits from using a more rapid and "more short tailed" insulin, it is probably not sensible to attempt an "unannounced meals (UAM)" study with such systems. (Compare also Univ.Stanford pig study in which iOS Loop showed much inferior performance compared to AndroidAPS in an experimental UAM mode comparison).
The developmental FreeAPS (ivan's branch of iOS Loop) seems to come closest to what OpenAPS and AndroidAPS offer. It is advised to wait for an official release with instructions how to use, in order to assess potential of running it without carb inputs (in some sort of UAM mode).
Lastly, I like to point to the fact that AndroidAPS loopers are instructed to use a (~circadian) basal rate that truly keeps glucose steady without food and other special effects. This seems important, so factors are not carrying a bias for basal-correction, and to allow the loop optimal regulating capacity.
Different philosophies prevail regarding basal rates (and factors) used for looping. It will be interesting to see how they do in an "UAM" challenge.
Meanwhile AAPS 2.7 (which
has changes in Autosense) has become available and should be used in further investigations.
For usage of Lyumjev replacing other insulins in a "normal" looping mode (B), tuning the breakfast and lunch IC settings (carb ratios) could be important. (Footnote)
"Tuning" settings for "UAM" utilization should be investigated. As there are not really many settings involved in UAM, this would mainly mean looking at ISF.
Also Autosense settings seem of very high importance, especially in the UAM mode (C).
More investigation on the UAM mode (C) are planned using moderate carb load meals, to gain more experience and understanding, before checking out limitations that may come with challenging high carb meals.
"Regarding carb ratio IC it could be expected that milder (higher) values would result when using an insulin with more rapid onset and shorter DIA.
With reference to extensive discussions in the German loopercommunity.org site on how carb absorption and insulin activity are principally out-of-sync in the hours following any meal, and therefore, how an optimal IC would be set, I rather expect the following:
With Lyumjev we see a shortened window of high insulin activity. Less grams of carbs will be absorbed in this time. Therefore, ideally less carbs should be entered for determining a user-triggered initial meal bolus (while more goes into the so-called extended carbs input for the later absorption time window).
As a result, the "old" IC value might still be valid with Lyumjev: A bit less insulin is bolusLyumjev_w.UAM-week_Be_13Oct20ed (in mode B) than with the previously used insulin(s)(in mode A). But also less carbs are being absorbed in the window of strong activity from that bolus.."
AndroidAPS
Faster Insulin
Luyumjev
oref1
Ultra Rapid Lispro
Abbott Freestyle Libre 3 – here already?
Lyumjev part 4. Persistence is king…
Tomas Mahony
Hi Tim, really interesting and exciting development. I'd love to see more such experimentation and see what happens. I'll be checking to see if this is available in Ireland. What is the situation regarding the curve setting in AAPS – is it available?
Indeed. Free-peak curve is available in AndroidAPS
Tony Sangster
Thank you for this detailed reporting. The weal link on the chain appears to me to be the reliance on the ADA- promoted maximum level of range of 10 mmol/l (180 mg/dl) blood glucose. This sets the patient up for potential HBAICs in the range associated with long term complications as per DCCT and UKPDS. The anecdotal ( because those implicated would never state so emohatically) reason for this maximum level is a hedge against being sued should the patient suffer from a hypo, a happenstance more likely in their thinking the lower and tighter the range is set ( and resultant HBAIC is set. This is despite the findings such as minimal hypo rate and actual measured ranges and HBAICs of the paper Pediatrics May 2018 Management of Type One Diabetes with Very Low Carbohydrate Diet authors Lennerz, Ludwig et al. which included diabetes adults, children and teens on mdi and insulin pumps ( but no augmented control systems that i am aware of. I also worry that control systems such as in the German study may increase the risk of dietary excess and the trend as exemplified in the study using US Type One Diabetes Exchange of increased obesity and overweight in TID populations ( including children).
I think it very much depends on your point of view in relation to TIR. You don't target a TIR of 97% in any of these systems. They work by targeting a glucose level (which is more flexible in some systems than in others). Many DIYers target 5.5mmol/l (100mg/dl) and below as their target level, and as a result have Hba1C levels that are not a concern in relation to any of the long term studies.
As the author mentions, the challenge with any automated system and a non-restricted diet and/or no manual intervention is that there is a need to predict what is about to happen to bring time in the zone between 140mg/dl and 180mg/dl down more effectively. Some commercial systems are looking at how this might be achieved. It's worth noting, however, that this type of performance for most with type 1 is still a long way off.
The other point I'd make is that self-reported outcomes of restricted diets are not limited to very low carb. While there is less published data, there are also reasonable reports of great outcomes on very low fat, vegan diets.
I think we have to accept that there seem to be multiple approaches to getting decent long term outcomes, but that there is more than just diet and technology involved. Socio-economic factors tend to play a much greater role in long term glucose levels and the resultant outcomes.
Thanks for another good article.
I found the lines about "Site reactions (hematoma)" particularly interesting, since I find cannula performance a particular challenge.
Do you think that the use of SMB as the primary delivery method improves cannula life, instead of large all in one meal boluses? The more i read, anecdotally at least, it seems to be the case. Do you know if anyone has tested this or perhaps intends to?
I don't know if anyone has tested whether use of SMB improves cannula life. It's certainly something that seems worthy of investigation. Personally, I've found that moving away from large boluses may make me more tolerant to Lyumjev (but that's an experiment that's ongoing) so this type of delivery approach may be more beneficial in multiple ways.


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The people's party
Andy MacMillan May 11, 2016 The people's party2016-05-11T07:49:07+01:00 Grassroots Labour, Opinion
Andy MacMillan identifies what he sees as key problems with Scottish Labour's recent campaigning, and says the answer cannot be more division or more tax.
I have written this article because I believe that something is fundamentally wrong within the Scottish Labour Party.
At the 2015 General Election, everyone took a tanking from the SNP. But at the 2016 Scottish Parliament Election it was only Scottish Labour that got mangled up. We can't simply gloss over this and pretend that we are moving in the right direction. It's obvious to everyone and their dog that we're going nowhere.
First and foremost, the most obvious mistake was that our leader Kezia Dugdale gave a bad answer in an interview and allowed us to be painted as being soft on the union. This one fatal blunder was totally devastating. Nevertheless, it's one amongst many, so let's move it along.
In the last Scottish Parliament 2011-2016 we let a few things through without kicking up enough of a stink.
Alarm bells really should have started ringing with the creation of Police Scotland. In 2013 the eight regional Scottish police forces were taken out of local authority democratic control and combined into one unit under the direct control of the SNP Government.
The Council Tax freeze is an affront to local democracy and should have been challenged more robustly.
The SNP's Named Person Scheme is a direct assault on the western democratic liberal tradition. This truly chilling Orwellian nightmare, guising as child protection should never have been supported by the Scottish Labour Party.
This is the backdrop as we entered the 2016 election year and all of the above factors are within the remit or influence of the Scottish Labour Party.
When you fight an election you need a good battle plan and a good selection of weapons at your disposal. Sadly in this election we had neither.
Much more should have been made of the SNP's overwhelming desire to centralise control, taking power away from local authorities and placing it into the hands of the SNP Scottish Government.
The plan for battle should have been organised around both the positive message of the Scottish Labour Party and a negative message of our opponents, especially the SNP.
Unfortunately our positive message was not all that positive and we balked at sticking the boot into the SNP. Activists were repeatedly told that the "SNP Bad" stuff doesn't work and that there was to be no negative campaigning. Thus we ended up with a dreadful cliché of a campaign, with our leader aping and copying much of the SNP's act, such as being photographed with loads of little kids and having "kids not cuts" instead of "bairns not bombs".
Then we had the "penny on tax" for education. This really is a desperate old policy, which is routinely pulled out by failing political parties. This policy was so bad on so many levels that it's difficult to comprehend any wisdom behind it.
We are the Labour Party. Historically we built our strength on our ability to fight, and we grew out of the union movement, which was basically a protection racket for working people. With truisms like, "give us a shilling and we will get an extra pound on your wages", coupled with "a fair days work for a fair days pay" it is little wonder so many people wanted to join unions. There was a simple truth in the phrase "unity is strength"; it actually meant something in those days.
Anyway, the point is that our movement was a success because it put money into people's pockets. That's why we became popular. It might not be the pretty sanitised romantic version of our history that so many like to foster, indeed many seem to think that our story started with the creation of the NHS, they don't seem to realise that this was a destination point.
So here we are Scotland 2016. The councils we still control have yet another council tax freeze and we have to cut services and pay off workers. It's worth remembering that these councils are democratically elected and that the people voted us in to deliver these services. Therefore it's an affront to democracy to not allow councils to either raise or cut council tax as they see fit. If the people don't like it they can vote the council out.
If we were going to raise tax anywhere it should have been in the councils we control. We should have fought the SNP over this matter. We should have sent out a strong and clear message that a Labour council will fight for local democracy and defend services. Sadly, this did not happen and the Scottish Labour Party leadership lay down to the SNP. In effect the Labour controlled Scottish councils were sacrificed on the altar for the 2016 Scottish Parliament elections.
Of all the positive things we could have offered the electorate we came up with a tax rise. It's like here come this Labour mob again and they just can't wait to get their hands into your pockets!
We could have said something like: we will build X amount of council houses, we will pay employers part of the benefit money to take on the unemployed, we will create enterprise departments to bring in inward investment and jobs, we will get everyone working which will in turn raise enough overall tax to have both a penny tax cut and improve public services. There are so many positive things that we should and could have proposed, but simply failed to do.
Trying to campaign in this election was a feat in itself; you needed a fair bit of front to knock the doors with our message. This wasn't helped by the fact that our manifesto wasn't released until the week before the election. Basically you were going round the doors with the candidate's leaflet (which was printed well in advance) with no policies on it. When you asked "why is this?" you got the answer that "they don't want to bring the manifesto out early in case the SNP copy it". When the manifesto eventually surfaced the "big" surprise policy was a breakfast club in every school. Stone me, that will get them queuing for miles outside every polling station.
So there you have it. We are a party that supports the union but then again we may support independence. You might not earn much, in fact you may well be part of the working poor, but never mind we will slam some more tax on you. We think it's a good idea to launch our manifesto after the postal votes have been cast. Furthermore, we're not too concerned about the creation of a police state, or having every family spied upon, all these things really don't bother us too much. We are also pretty relaxed about letting the SNP decimate our council services and local democracy. To top it off, one of our flagship policies seems to be putting out a bowl of cornflakes for school kids.
Home Rule? No Thanks.
In London there is a money tree that grows year on year called the "City of London". This money tree provides massive tax revenues for all UK citizens.
The SNP want to give away our rights to this money. The Conservatives think that the rich should keep this money for themselves. Only the Labour Party wants to redistribute this money amongst all UK citizens.
But it's not all about the money. There are some things that money just can't buy, with friendship and loyalty being amongst them. During the height of the fighting with the Thatcherites in the 1980's, working people throughout Britain helped and supported each other, you don't forget things like that and you don't turn your back on your friends.
We are the Labour Party. We have never defined ourselves by nationality, religion or race. We are the people's party.
Malcolm McCandless - May 11th, 2016 at 8:56 am none Comment author #134890 on The people's party by Labour Hame
A person still fighting the 2016 elections – YOU LOST.
Alan Findlay - May 11th, 2016 at 9:59 am none Comment author #134893 on The people's party by Labour Hame
'We are the people's party'
You are the Slab party that abandoned Trident then let yourselves be bullied into silence when your UK trade union sponsors told you the future of their members was more important than the rest of the world;better together my arse.
Alan J - May 11th, 2016 at 11:10 am none Comment author #134894 on The people's party by Labour Hame
Andy, The Labour party here is the SCOTTISH Labour party, if not independent yet. What is that if not defining us by nationality ? We have a Scottish parliament with different policies to England. Free prescriptions, free education etc
So how does independence or federalism mean turning our back on our friends, any more than existing devolution does ? They will still be friends and comrades. Would our friends down south even want working people in Scotland to suffer Tory government after Tory government when we have a chance to escape that, and have a more progressive Scotland ?
The fact that London is so dominant is hardly a great argument for the union, and Blair/Brown governments did little to rebalance Britain when they were in power. In any case, Labour could still at least propose a federal structure which retains a fiscal balancing mechanism, yet allows far more autonomy for Scotland.
The tax position didn't lose it for us, although it didn't help.
Nor was it Kezia's comment, because everyone knows that Labour supporters are genuinely divided on the constitution, if not the current Scottish leadership who want to ignore reality and hope that SNP support will magically fade away in the future.
Maybe Anas Sarwar has it right: "We are not comfortable unionists and we are not comfortable nationalists".
And many voters don't see independence simply as old fashioned nationalism, but as a means to a fairer, more equal society. A call to hang around as part of the UK sometimes seems like British nationalism disguised as solidarity. No better or worse than Scottish nationalism.
If we have to choose, it just seems like one of these comes with constant Tory governments, and one has a chance to keep them locked out.
Riddok - May 11th, 2016 at 11:36 am none Comment author #134896 on The people's party by Labour Hame
"Alarm bells really should have started ringing with the creation of Police Scotland"
which labour campaigned on and voted for, and fully supported at the time – all parties did
"The Council Tax freeze is an affront to local democracy"
Such an affront that it was Glasgow Labour's number 1 promise, on their 2012 council election manifestoto keep the freeze until 2017.
"The SNP's Named Person Scheme is a direct assault on the western democratic liberal tradition. "
The nill that Labour filly supported an voted for in 2014
"We therefore supported the principle as a protection for children who needed it, and a means to detect and provide families with additional help they may need." Kezia Dugdale
"We are also pretty relaxed about letting the SNP decimate our council services and local democracy."
The SG budget DEL has been cut by 10% over the past 5 years, council budgets have been largely protected and stabilised until this year, and have not been cut by the same amount over the same period. Since Labour fronted Better Together are you saying the councils should have the cuts forced on the SG passed on to them?
"In London there is a money tree that grows year on year called the "City of London"."
is that the same money tree that crashed spectacularly in 2008 and we are still paying for the bail out almost a decade later? a money tree where the money is dispersed closest to it and fails to reach the more northerly areas? Deficit – the UK cannot raise what it spends so the money tree really isn't bearing fruit.
"The SNP want to give away our rights to this money. "
No the SNP want to stop giving Westminster all our money and receiving just over half of it back
"The Conservatives think that the rich should keep this money for themselves"
as did new Labour – and they do – the rich have become much richer
"and you don't turn your back on your friends."
like doing the dirty work for the Tories during the indyref
Robert McDonald - May 11th, 2016 at 1:16 pm none Comment author #134900 on The people's party by Labour Hame
"we grew out of the union movement, which was basically a protection racket for working people"
Wow!, Just wow!
Riddok - May 11th, 2016 at 1:48 pm none Comment author #134903 on The people's party by Labour Hame
no matter how many times since 2007, every time the public passed judgement on labour and the slide was a clear trend they didn't learn the lessons – and they still haven't.
much in this article was good but it's bracketed by the same noises no-one is listening to anymore
Chris - May 12th, 2016 at 9:56 am none Comment author #134920 on The people's party by Labour Hame
Can't quite believe we have a supposed Labour person here calling the City of London a 'money tree' that we all need to respect, cherish and value for all the windfalls that drop from its branches..!?
Um, financial crisis, anyone? Full scale bailout of the financial sector? £1.5 trillion of UK debt?
Is Labour really the party that defends the City? Wow.
solrighal - May 16th, 2016 at 8:54 am none Comment author #134957 on The people's party by Labour Hame
Dear Andy, You're in the wrong party. That is all.
« Taking the long way
Home Rule proposals are a mistake »


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Dr Sreenath Dixit
Cluster Leader – ICRISAT Development Center
Principal Scientist
Dr. Sreenath Dixit is the Head of the ICRISAT Development Center (IDC), a research cluster under the Global Research Program -Resilient Farm and Food Systems. He collaborates with the Global Research Program Director to deliver impactful outcomes to smallholder farming systems. He guides and supervises a multidisciplinary team of natural resource management experts and social scientists to develop and deliver climate-resilient agriculture technologies and improve productivity for smallholder farmers. Furthermore, Dr. Dixit is responsible for mobilizing and building partnerships with governments at the state and national level, along with private and public entities, to support ICRISAT's goals. As the Head of IDC, Dr Dixit, with his knowledge of the Science of Delivery and the impact pathways, is striving to achieve positive outcomes for smallholder farmers. Additionally, he also has experience mobilizing resources, and collaborating with partners, like farmer organizations and governmental line departments, effectively.
With a doctorate in Agricultural Extension from the University of Agricultural Sciences, Bangalore, India (1993), he belongs to the 1990 batch of Agricultural Research Service (ARS) of the Indian Council of Agricultural Research (ICAR). His efforts have led to many ICAR awards, such as Vasantrao Naik Award for Dryland Agriculture and the Fakhruddin Ali Ahmed Award for Tribal Agriculture Improvement besides the Young Scientist award of the Indian Society of Extension Education early in his career.
In his career spanning over 30 years, he has served in different capacities with National Research Centre for Cashew, Puttur (1992-99) and Central Research Institute for Dryland Agriculture, Hyderabad (1999-2014). He headed the Agricultural Technology Application Research Institute, Bengaluru as its Director (2014-18) before moving in to ICRISAT. He has also served ICRISAT earlier in his career in two different projects between 2002-06.
He has over a hundred publications to his credit and published about 80 research papers both in national and international journals, written over 35 book chapters, and several project reports and policy papers. Besides, he has also published over 100 popular articles on a wide range of subjects including agriculture, education, rural development, etc.
Expertise: Participatory natural resource management, innovative institutional mechanisms for promoting sustainable rural livelihoods in fragile ecosystems, technology testing and frontline extension strategies, location-specific adaptations to climate change and ICTs in agricultural extension.
Evaluating the trade-offs and sustainability of minimum tillage and crop-residue addition for food production in the dryland tropics
Reducing risk of crop failure by building system-level resilience through science-based natural resource management interventions: A case for rationalising crop insurance premia
on July 1, 2022 at 5:00 am
Detecting Soil pH from Open-Source Remote Sensing Data: A Case Study of Angul and Balangir Districts, Odisha State
on May 5, 2022 at 9:38 am
Decadal variations in CO2 during agricultural seasons in India and role of management as sustainable approach
Bio-conversion of rice straw waste in to high quality organic fertilizer


For Twitter all you need to do is tweet " "I love @PIPManchester because they are raising awareness of #polandsyndrome #ILoveSmallCharities" You must include @PIPManchester and the #ILoveSmallCharities for the entry to be counted. Only one per person is counted so know need to keep re-tweeting!
PIP-UK is a member of the FSI (The Foundation of Social Improvement). Which is a non-profit organisation for small charities. We work with the FSI to become better at running our charity by attending the training courses they run every year. We also have access to a wealth of knowledge and support. The FSI also run events like the e-bay charity auction, the Christmas car raffle and the small charity week. The idea is to bring small charities together to pool resources for the greater good.


What Features Should a Timekeeping Management System Have?
Timekeeping management systems have come a long way over the past 10 years, especially when you think back to how time worked used to be logged. It was so easy for employees to add extra time to their timecards each pay period when using a time clock, a sheet of paper or any other form of timekeeping.
Employees also used to have an easy go of it when punching the clock for their friends at the office, even if they were not present. Newer timekeeping management systems prevent a lot of these issues due to new features. Today, we will discuss the best features a timekeeping management system should have.
One of the first features your new timekeeping management system should have is the ability to manage payroll. A new system should allow you to track how many hours an employee worked during the week, how long they took for breaks and plenty of other data. If you like employees clocking in for special company events, this can be tracked as well. All of this data will help you determine how much employees should be paid, especially if they are hourly workers.
These new PTO tracking software programs also allow for a guard on the timeclock installed on them. The guard will notify management, or whoever runs payroll, if an employee not scheduled to work is trying to clock in. There are also settings where the system will deny employees from clocking in if they are not logging in from the office based on IP address. To take this further; you can set limits to which computers in the office can be used for clocking in and out by employees. Alerts can also be sent if an employee is clocking out well in advance of their shift ending for the day.
Many companies require travel out of their employees. Some will go as far as providing a company car, such as repairmen, plumbers or government employees. For those who have to travel using their personal vehicles, gas mileage reimbursement is typically done by employers. If this is the case, your timekeeping system should have the ability to track mileage and then calculate gas mileage in order to reimburse the employees.
Even though the system is automated mistakes can still occur. Because of this, your timekeeping software should have a request for time change sheet that can be completed and submitted by employees. Errors can occur on an employee's electronic timesheet for various reasons. A request for time change sheet can be filled out by the employee and submitted to the manager in charge of the system. The manager can then review the requested change and approve or deny it.
Dealing with employee absences and scheduled time off is not an easy thing in today's fast-paced world. Your new timekeeping program should have absence management software included. This will help keep track of when employees called out sick, left work early due to illness and when they missed work for any other reason. The software should also allow you to schedule them for time off in the future. All requests for time off should be submitted by employees via the new system.
Isn't it frustrating when you have to search for what you are looking for in a program? Well, your timekeeping software should have a functioning dashboard that has everything you need in one convenient spot. This includes payroll, scheduling, alerts and more. You should even be able to clock in and out from the dashboard without pressing too many buttons.
The best time & attendance systems out there have separate overtime settings to better track the work performed by employees. Some companies pay overtime wages to both hourly and salaried employees, which is why separate settings are important. This setting will allow you to set the work week start and end day for overtime purposes. Then you will be able to calculate overtime for a 40-hour workweek, an 80-hour workweek and overtime paid out on individual work days.
Lastly, you will want to look for a program that has some biometric settings in it before making the switch in your timekeeping. This will make it easier for employees to clock in and out of work, prevent theft of company time, prevent buddy punching and save payroll employees a ton of time deciphering handwritten timesheets or spreadsheets.
The next time your company wants to switch its timekeeping program to an absence tracker, make sure the new program has a majority of the features listed in today's post. These features will only make the switch to the new program easier and will make timekeeping and recordkeeping more fluid throughout the company.


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Home » Interviews » The Story of Standpoint: We Interview the Writer and Actor
The Story of Standpoint: We Interview the Writer and Actor
This entry was posted in Interviews on March 19, 2014 by vethan
In Standpoint you're never alone. There is always another presence accompanying your journey. Who is she? Why is she here? We caught up with Michael Gillespie (Writer) and Holly Meyrick (Actor) to shed some light on the subject.
So, how did you get involved with Standpoint?
Mike: I lived in Bristol for a while and encountered the one the Internet calls Vethan; he indulged my penchant for drinking on boats. Initially we chatted a lot about comedy but in and around the discussions of his programming and my writing he pitched his concept for Standpoint.
I liked the initial premise he presented and how he wanted the game's main mechanic to represent it; I thought I could build the kind of story he wanted and agreed then and there, on the boat, and mostly free of the effects of anything imbibed, that I would write for Standpoint.
What's the general outline of the story?
Mike: For those of a cryptic disposition, the demo is full of hints and clues. To outline, the character you play as is working through the various stages of this labyrinth world under the supervision of the Narrator to try and discover something but has to alter the 'Standpoint' to do so.
I really don't want to give anything away cheaply, but those who have searched the demo and found the secret areas will have heard a shade more of the Narrator's character. As the game progresses the story can be unraveled until you discover who the protagonist is, the nature of the world you play through, why you are there and what the relevance is of that omnipresent voice. That's all I'm saying.
What does the Narrator mean to you?
Holly: It's an important role as there is a real depth of concept within this game and the Narrator is the core of this. We have discussed the motivation behind each line but it's for the player to interpret. It's fun being a part of the puzzle. The narrator both assists yet confuses. It's been amazing being part of the narrative of the piece and seeing it develop!
What's it been like so far?
Mike: It's reminded me of the reasons I took to writing and why I've always had an interest in story-telling in gaming – I agree with Amy Hennig on how important creative expression is to the future development of gaming. The last game I played while working on the Standpoint plot was a major release and I couldn't quite believe how uninteresting I found it; visually it was a spectacle and an impressive, expansive piece of work but I felt the story was so sparse I lost the will to play it.
I'd like to make Standpoint into a page-turner of a game, like that novel you can't put down or that film you don't want to end – that's the challenge for me. The work everyone else is doing is great to keep up with and I get a kick out of how the script is being brought to life.
Holly: It's been a really fun experience. It's such a lovely team that have worked so hard to pursue their dream. It's amazing how much they've accomplished. I was just around for the finishing touches really, they had done all the hard work before I was brought on to the team. Working with Dan on the sound elements has been great fun. He's got great direction. He's the one that makes it all sound great!
Why should we be excited for the rest of the game?
Mike: The demo is just a morsel. Knowing what is planned on the programming and building side alone is exciting. The gameplay of Standpoint gets much more challenging; it'll use the gravity mechanic much more extensively in a lot of adventurous ways. I've seen a few of the art samples, which will completely change the atmosphere of the levels along with the craft of our music man. Also, I know what happens in the story so I think that the finished product is going to look, sound and play brilliantly and the plot should be addictive and a real jaw-dropper when you get there.
Holly: We've only really begun to scratch the surface of this game. There's so much more to come. It explores some really complex areas of human emotion and to see that unfold in the capacity of a game is going to be a real journey!
Working with Holly in the studio has been great fun. Of course, like any recording session, we won't want to use every take… For some behind the scenes action check out the demo blooper reel!
https://soundcloud.com/unruly-attractions/prolouge-demo-blooper-reel
← The Secret Shader of Standpoint
New Unruly Website! (beta) →


Infinity Blade, Epic Games' first iOS release, is a sword duelling, monster snuffing game in need of a microsite. To appeal to a whole new class of user for a video gaming company, and to address the unique purchasing patterns, I deviated from the typical over-cluttered, outdated design of most video game microsites. Instead, I fine tuned a more open, cinematic, responsive personality.