Today in church, there was a discussion about developing talents. You know... pursuing your interests and putting time into talents so that they "multiply." Way better than burying talents. (Matthew 25:14-30) This all made me think about mothering.
Lucy has been interested in gymnastics and violin for years. She has a real desire to progress in both areas. They're not her only interests (swimming, cooking, drawing, and science also interest her a lot), but they're the ones she's focusing on for now. AND YET, it's rare that she doesn't need encouragement from me in one form or another to work on these "talents."
I know from experience that all parents don't do this. Many don't have the time or energy. By the time I rolled around, my parents would allow me to sign up for classes, but they didn't press the issue if I didn't feel like practicing. If I stopped practicing, the lessons stopped too. I think both approaches teach valuable lessons. Sometimes I find myself thinking about being able to play the piano, lamenting my mother's unwillingness to force me to practice. But that's just ridiculous. I had plenty of interests which developed without hand-holding from my parents: reading, art, soccer, languages, karate, yoga, backyard volleyball, basement dancing expositions with friends, etc.
On one hand, Lucy is learning right now that perseverance (mine and hers, I guess) pays off. We are both learning that dreams are attainable through hard work and consistency--not necessarily perfect consistency, but through dedication. Now is probably a good time to explain that if it were left up to me completely, I would probably have Lucy enrolled in just tumbling and maybe dance. She loves gymnastics, though--bars and beam more than floor. And the violin is something that she came up with 100% by herself.
Gabe is a little different. He's still 4. He was in gymnastics because he wanted to be, but I pulled him out because he refused to go about 50% of the time. This gives us a concrete example of what happens when you don't do those hard things that don't sound fun. Here's the gist of my spiel: "When you don't do the hard things, you miss out on chances to practice. Without practice, as awkward and as painful as it may be, progression is not going to happen."
Gabe has been asserting his independence lately by sometimes deciding not to participate in swim lessons. I haven't made him get in the pool, but he does have to come with us, of course. Last week, he was going on his second day of non-participation, but after a little lecture along these lines, Gabe decided that he would go to swim lessons. Actually, he suggested that he would commit to going to every lesson so he could start gymnastics again. That kid can understand me pretty well sometimes.
With Charlie, we're still focused on helping him not hurt himself or other people too much.
One of my strongest character traits is enthusiasm. There are pros and cons to being naturally enthusiastic. If you haven't heard or read my thoughts on all of that, just ask me and I'll go on as long as you keep listening to me.
One of the issues that arises, though, from a natural and almost irrepressible enthusiasm is that I get a lot of new stuff coming into my life. I also see a lot going out. Not many of my passions/obsessions/hobbies make the cut.
My newest hobby is snail keeping. It turns out that snail keeping is a pretty great way for me to chill out.
I was weeding one day with a friend and my boys were with me. Whenever I'm working in the dirt and come across something living, it is the subject of great excitement and the kids immediately want to make it a pet. Roly polies, worms, and snails all qualify as cute and keepable in their eyes.
When Gabe asked me if he could keep the snails he found, I remembered a little specialized ventilated glass box that I got on clearance from the pet store for Christmas. It was really too small for most animals, so it was being used to hold down a corner of a shelf in a closet. Snails, though... snails could make do in a little glass box with a top screen and a back wall made of painted foam rock.
That first round with snails was short lived. I let the kids take them out and handle them whenever they wanted, and the poor snails got left in the sun without adequate water. I learned a lot, though. I learned a lot more about snails than you probably want to read here.... and I learned how relaxing it is for me to watch them.
If you can get past the ick factor, snails are amazing little animals. When they slide over a pane of glass, you can see the symmetrical ripples of their foot which propel them along. When they eat with their disappearing mouths, you can hear the crunching of your compost scraps. And you can watch that food moving up through their heads into their bodies. The way their feelers and eyes retract and extend is fascinating. Yes, friends: I have found that a snail's pace is ideal for stress relief. They're free, and when we're done with them, we plan to feed them to our neighbors' chickens.
I would post my own picture here today, but I need to clean their cage again. Keeping nine snails in a 10"x10" box does not let the walls stay clear of snail poop and slime for long.


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Combination Washing and Tumble Dryer machines (Washer/Dryers) are a convenient, space saving appliance as they combine both washing and drying functions.
It is important to be aware that Washer/Dryers have a lower drying capacity than standalone Tumble Dryers and are typically less energy efficient. This is because the appliance requires components from both Washers and Dryers; dedicated Tumble Dryers only have an outer drum resulting in more fabric being in contact with hot/dry air at any one time, while Washing Machines require both an inner and outer drum. The presence of the inner drum in a Washer/Dryer affects drying capacity and efficiency.
The biggest benefit of Washer/Dryers is their space saving potential, and it is convenient that the unit does not need to be reloaded between wash and dry routines.


Extended Stay Deluxe Atlanta Northpoint is located in the city of Alpharetta and is placed less than a kilometres from the Old Milton Parkway. Nearby attractions include Stone Mountain Park, Turner Stadium, World of Coca Cola and Georgia Dome.
The hotel boasts comfortable accommodation units that are elegantly decorated and fully equipped with every comfort that offers guest a pleasant and relaxing stay.
This property does not have a restaurant. Guests who love to cook can prepare their own meal in the comfort of their fully equipped kitchen.
Guests can also explore the city of Alpharetta and its beautiful attractions or take a refreshing dip at the swimming pool.


• I AM a trader of six years' standing with a stall in the Hampstead Community Market. I have this week received a letter from Richard Weaver telling me it is no longer to be available on Saturdays as a craft market.
This has been a well-loved institution in Hampstead Village for a long time.
One of my fellow traders has had her antique jewellery stall for 40 years and is a well known figure locally.
We are all devastated at having received this notice with no warning.
And what is the market going to be used for? Food. Food, when there are a great many food shops in Hampstead, Even a Tesco! How many food shops do we need?
Perhaps the most dismaying aspect of all this is that we have been kept totally in the dark.
No chance to seek alternative spaces when there are only four weeks left before they close.
Hampstead will have nothing of this kind now. We who have our regular customers will lose not only our livelihood but our friends.
Surely the profit motive should not be the only reason for such endeavours?


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Dhyan Chand – Magician of Hockey
Posted on July 18, 2016 by Team WinJuly 17, 2016
Dhyan Chand, a greatest field hockey player of all time. Chand is most remembered for his extraordinary goal-scoring feats, in addition to earning 3 Olympic gold medals (1928, 1932, and 1936) in field hockey, during an era where India was the most dominant team in Hockey.
He Known as "The Wizard" for his superb ball control, Chand played his final international match in 1948, having scored more than 400 goals during his international career. The Government of India awarded him the third highest (then second highest) civilian honour of Padma Bhushan in 1956. His birthday is celebrated as National sports day in India (August 29th).
Young Chand had no serious inclination towards sports, though he loved wrestling. He stated that he did not remember whether he played any hockey worth mentioning before he joined the Army, though he said that he occasionally indulged in casual games in Jhansi with his friends. Chand joined the Indian Army at the age of 16.
In India he is often referred to as 'Hockey ka Jaadugar' with translates to "Magician of the game of Hockey".
Dhyan Chand – Magician of Hockey — 1 Comment
Tailynn on August 16, 2016 at 12:22 am said:
That takes us up to the next level. Great poigsnt.

redpajama_set_name: RedPajamaCommonCrawl


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ADF International hosts panel at European Academy of Religion
news | Published on 23 Jun 2017 13 Jul 2018
ADF International speaks on challenges faced by people of faith in Europe; Prominent participants included Jan Figel and Romano Prodi
BOLOGNA – On 21 June, ADF International hosted an expert panel at the annual conference of the European Academy of Religion in Bologna, Italy. The annual event gathers 700 scholars, practitioners, and officials in the field of religion from around the world.
The European Academy of Religion was launched in December 2016, and aims to connect scholars, research centres, and institutions which work in the field of religion. ADF International hosted a panel at the conference, which is held under the patronage of the European Parliament and of the European Commission.
"Freedom of religion is not only a fundamental right but is also essential for the development and preservation of an open, pluralistic, and inclusive society. There cannot be a well-functioning democracy without respect for religious freedom. Despite this, we see that freedom of religion or belief is under pressure in many parts of Europe", said Adina Portaru, Legal Counsel for ADF International.
Freedom of religion across Europe
ADF International therefore hosted an expert panel that analyzed current challenges faced by people of faith in Europe.
An increasing number of people are not free to live out their faith.
"An increasing number of people are not free to live out their faith. This happens not only in the Middle East, where Christians and other religious minorities are deliberately targeted by ISIS for destruction, but also across Europe, where citizens are facing an insurmountable conflict between either violating their conscience or facing punishment by the state", said Sophia Kuby, Director of EU Advocacy at ADF International.
The event was attended by Mr Jan Figel, Special Envoy for the Promotion of Freedom of Religion or Belief Outside the EU, and Mr Romano Prodi, former President of the European Commission.
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Suspended pro-life student secures settlement from University
NOTTINGHAM (25 November 2020) - Are universities stifling students' views? Midwifery student Julia Rynkiewicz believes so, and her newly-settled case provides one such example. Rynkiewicz served as president of "Nottingham Students for Life", a pro-life student society that was...
Published on 25 Nov 2020
UK students feel censored on campus, poll finds
LONDON (6th November 2020) - Universities are supposed to be bastions of free speech. Yet according to a nation-wide poll released today by ADF International (UK), almost 40% of students admit fears that expressing their views on campus could adversely affect their future career opportunities. Over a third...
The decision on Ashers bakery is a victory for everyone
After more than four years, the UK Supreme Court handed down its decision in the case of Ashers Bakery – also known as the 'gay cake' case. In a unanimous...
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In February 2009, President Obama directed the National Security Council (NSC) and Homeland Security Council to conduct a 60-day review of the plans, programs, and activities underway throughout government that address our communications and information infrastructure (i.e., "cyberspace"), in order to develop a strategic framework to ensure that the U.S. government's initiatives in this area are appropriately integrated, resourced, and coordinated.
Threats to the information and communications infrastructure pose one of the most serious economic and national security challenges of the 21st Century for the United States and our allies. In this environment, the status quo is no longer acceptable, and a national dialogue on cybersecurity must begin today. The U.S. Government cannot succeed in securing cyberspace in isolation, but it also cannot entirely delegate or abrogate its role in securing the Nation from a cyber incident or accident. Ensuring that cyberspace is sufficiently resilient and trustworthy to support U.S. goals of economic growth, civil liberties and privacy protections, national security, and the continued advancement of global democratic institutions requires working with individuals, academia, industry, and governments. We must make cybersecurity a national priority and lead from the White House.
The review team's report to the President contains five main chapters, outlined below, and includes a near-term action plan for U.S. Government activities to strengthen cybersecurity.
(U) Chapter I: Leading from the Top – Makes the case for strengthening cybersecurity leadership for the United States through 1) the establishment of a Presidential cybersecurity policy official and supporting structures, 2) reviewing laws and policies, and 3) strengthening cybersecurity leadership and accountability at federal, state, local, and tribal levels.
(U) Chapter II: Building Capacity for a Digital Nation – Advocates a national dialogue on cybersecurity to increase public awareness of the threats and risks and how to reduce them. Outlines the need for increased education efforts at all levels to ensure a technologically advanced workforce in cybersecurity and related areas, similar to the United States' focus on mathematics and science education in the 1960s. Identifies the need to expand and improve the federal information technology workforce and for the Federal government to facilitate programs and information sharing on cybersecurity threats, vulnerabilities, and effective practices across all levels of government and industry.
(U) Chapter III: Sharing Responsibility for Cybersecurity – Discusses the need for improving and expanding partnerships between the Federal government and both the private sector and key U.S. allies.
(U) Chapter IV: Creating Effective Information Sharing and Incident Response – The United States needs a comprehensive framework to facilitate coordinated responses by government, the private sector, and allies to a significant cyber incident. This chapter explores elements of such a framework and suggests enhancements to information sharing mechanisms to improve incident response capabilities.
(U) Chapter V: Encouraging Innovation – The chapter addresses ways for the United States to harness the benefits of innovation to address cybersecurity concerns, including work with the private sector to define performance and security objectives for future infrastructure, linking research and development to infrastructure development and expanding coordination of government, industry, and academic research efforts. It also addresses supply chain security and national security / emergency preparedness telecommunications efforts.


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The precarious future of the Affordable Care Act
Posted by Greg Marchildon
Seven years after its passage, the Affordable Care Act (widely known as Obamacare), has suffered its share of abuse. Yet after hundreds of bills to repeal it, two high-profile Supreme Court cases, and countless hours of strategizing in Washington and in state capitols across the country, it just won't die.
Nor, however, will the Republicans ever quit trying to kill it.
The latest legislation aiming to "repeal and replace" Obamacare met its fate on March 24 when it was pulled from consideration hours before a scheduled vote. While Donald Trump had given his blessing to the Republican bill – the American Health Care Act, no less – it was largely crafted by Republican congressional leaders. Nevertheless, the bill alienated the House Freedom Caucus, a key voting bloc, because it did not go far enough at gutting Obamacare's tax subsidies for the purchase of health insurance and the regulations that require minimum healthcare benefits for consumers in the individual marketplace.
House leadership did not give up, however. After the scuttled vote, they continued to hammer out a legislative compromise with members of the Freedom Caucus, resulting in a floor amendment that allowed states to waive key regulatory provisions of the Affordable Care Act, including those that protected individuals with pre-existing conditions from discrimination by insurers. Nevertheless, the bill's future is uncertain. Given the popularity of the ACA's consumer protections, and considering that the American Health Care Act would lead to coverage losses for 24 million Americans, the bill has alienated Republican moderates and, even in the event a House victory, would be unlikely to make it through the Senate.
Despite this ongoing attempt to revive "repeal and replace," many pundits think the Trump administration and congressional Republicans should leave Obamacare alone and move on to other issues. Conservative commentator David Frum recently wrote that Obamacare is now "accepted by enough voters – and especially by enough Republican voters – to render impossible the seven-year Republican vision of removing that coverage from those who have gained it under the Affordable Care Act." By the start of 2017, the uninsured rate had dropped below 10%, compared to over 15% in 2009.
Should Republicans in Congress fail to pass legislation in the short run, Trump may attempt to quietly use the executive branch to soften the ground for repeal. There are several ways in which he could do this. First, the administration could eliminate the cost-sharing reduction payments through which, according to the New York Times, the ACA "pays [subsidies to] health insurers to offer plans with lower deductibles and out-of-pocket expenses to about seven million lower-income and middle-class people". Because this subsidy program is central to the ACA and the health-insurance marketplaces it created in the states, such a move would destabilize those marketplaces and likely lead insurers to pull out of those marketplaces, seriously weakening this component of the reform.
Second, regarding the exchanges, the administration could change the rules of health insurance markets currently in place so that at least some states would be left with no insurers to choose from to populate the health insurance exchanges.
Third, the administration could simply stop enforcing the provision in the ACA that requires individuals and small businesses to pay a penalty if they do not buy insurance. Soon after coming into office Trump signed an executive order giving executive agencies more discretion in enforcing the ACA. It was unclear what this meant, but one possibility is that the IRS will take a softer line in its policing of the mandate provision. In turn, this would undermine one of the mechanisms through which the ACA attempted to collectivize the insurance markets.
While Trump pitched the Republican bill as a solution to high premiums and out-of-pocket costs experienced by many health care consumers, few Republicans in the House were interested in solving these problems. Instead, they saw "repeal and replace" as an opportunity to cut taxes and entitlement spending. Unsurprisingly, the bill would have made Obamacare worse, not better.
That doesn't mean the status quo is sustainable. In its final form, Obamacare ended up being a giveaway to the insurance and pharmaceutical industries in the United States. There is little truly effective cost control built into the act and there is no public alternative to private insurance that could act as a release valve when (not if) private insurers price gouge or resort to questionable tactics to avoid taking on high-cost subscribers even though they are formally required to do so under the law.
These are challenging policy problems. But there is little evidence that Republicans care about solving them.
Greg Marchildon is Professor and Ontario Research Chair in Health Policy and System Design at the University of Toronto and a member of the Broadbent Institute board. Daniel Bėland is Professor and Canada Research Chair in Public Policy at the Johnson-Shoyama Graduate School of Public Policy at the University of Saskatchewan. Philip Rocco is Assistant Professor of Political Science at Marquette University in Milwaukee, Wisconsin. Alex Waddan is Associate Professor in American Politics and American Foreign Policy at the University of Leicester in the United Kingdom.
Image: via Obama White House Archive, CC 3.0 BY US
barack obama 2 public services 4 health care 10 US politics 1 Donald Trump 1


WALTHAM, MA (September 20, 2017) – Inflexxion, Inc. announced today that Allscripts has certified PainCAS™ as part of the Allscripts Developer Program. PainCAS enables Allscripts ambulatory EHR users to assess pain, functioning, and risk of problematic opioid-related behaviors in patients with chronic pain.
Developed in part with support from the National Institutes of Health (NIH), grants (Grant No. R44DA026359, PI S.F. Butler and Grant No. R44DA015617, PI S.F. Butler), PainCAS is a scientifically validated web-based, patient self-report clinical tool for assessing pain and opioid misuse risk in patients with chronic pain.
The Allscripts Developer Program (ADP) offers both proprietary and FHIR® enabled APIs to connect third-party applications, devices and other innovative healthcare technologies with Allscripts products. Allscripts has been supporting API integration since 2007 and is enabling over a billion data exchanges each year – the largest documented utilization of APIs in healthcare.
Find more information about PainCAS on the Allscripts Application Store. Health IT developers can create a free Allscripts Developer Portal account to access the Allscripts Open APIs and start building or connecting new innovations for Allscripts users.
Inflexxion helps healthcare organizations, provider communities, pharmaceutical companies, and regulatory authorities to improve patient care and inform public policy. Through their strategic approach and depth of expertise, Inflexxion analyzes and disseminates health-related data for surveillance, risk management, epidemiological studies, quality improvement, and outcome measurement. Inflexxion's unique data collection includes multiple data streams at the point-of-care, Internet Monitoring technology, and web-surveys with hard to reach populations. For more information visit www.inflexxion.com.


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ASH 2017
Lymphomas and CLL
Older Patient HCT
Post-Transplant
Patient Eligibility
CIBMTR Publications
Pediatric HCT
Non-Malignant Disorders
HLA Matching
Preparative Regimens
BMT CTN Publications
Unrelated Donor HCT
CIBMTR Research
Education Activities
Stay up-to-date on the advancing field of HCT with short summaries and links to the most relevant published research.
Geriatric impairments in cancer patients affect caregiver health, QOL
Kehoe LA, et al., J Am Geriatr Soc – A study of 541 patients age 70 and older with advanced cancer has shown a significant association between the number of patient geriatric assessment (GA) impairments and poorer emotional health and quality of life (QOL) in caregivers. The researchers conclude that clinicians should address caregiver needs when patients have a high number of GA impairments.
Low-grade aGVHD positively affects OS for patients with early disease stage ALL
Yeshurun M, et al., Blood Advances – Development of low-grade acute graft-versus-host disease (aGVHD) lowers relapse risk and positively affects overall survival (OS) for patients with acute lymphoblastic leukemia (ALL) in complete remission one and two). That's the conclusion of researchers who aimed to better understand the graft-versus-leukemia effect in patients with ALL, and how disease stage and severity of GVHD impacts hematopoietic cell transplant outcomes.
Geriatric assessment and targeted interventions recommended for older patients undergoing allogeneic HCT
With an increasing number of older patients undergoing allogeneic hematopoietic cell transplantation (HCT), researchers studied the incidence and impact of transplant-related geriatric syndromes. The results suggest that older patients may benefit from geriatric assessment and targeted interventions aimed at i
Event-free survival improved with midostaurin for patients with FLT3-ITD-mutated AML
The addition of the multi-targeted kinase inhibitor, midostaurin, to chemotherapy followed by allogeneic hematopoietic cell transplantation (HCT) significantly improved event-free survival (EFS) for patients with acute myeloid leukemia (AML) with FLT 3 internal tandem duplication (ITD). That's according to the
Timing of molecular testing may enhance treatment decisions for patients with AML
For patients with acute myeloid leukemia (AML), the timing of molecular testing can enhance patient management decisions and clinical trials recommendations. Researchers highlighted evidence that supports molecular testing at diagnosis, complete remission and relapse. At diagnosis, gene panel sequencing
Geriatric assessment helps inform decision making and management for older adults with AML
Loh KP and Klepin HD. Blood Advances - The presenters of this Blood Advances Talk recommend geriatric assessment for older adults with acute myeloid leukemia (AML). They reason that adults of the same age can vary based on underlying health status and physiologic reserve, therefore, decision making and management cannot be optimized using strategies based on chronologic age.
Emerging prognostic factors identify older adults with high-risk AML likely to benefit from HCT
Veltri L, et al. Bio Blood Marrow Transplant - In a recent study, researchers analyzed hematopoietic cell transplant (HCT) outcomes in 185 patients (age >65) with high-risk acute myeloid leukemia (AML) and found the strongest independent risk factor for overall survival (OS) and relapse was associated with achievement of measurable residual disease negative status prior to HCT. Additional prognostic factors identified in this study could help identify patients most likely to benefit from HCT treatment.
How I Treat Older Adults with Sickle Cell Disease
Thein SL and Howard J., Blood Journal – In this installment of the "How I treat…" series, the authors highlight that for patients with sickle cell disease, survival has significantly improved. Consequently, adults face new long-term risks of their disease as well as age-related conditions.
Using quality of life to inform treatment decisions for older patients with cancer
A Task Force of the International Society of Geriatric Oncology recommends all health care professionals involved in the care of older patients with cancer should place a greater focus on quality of life (QOL), and treatment decisions should not be made based on chronological age alone. (Scotté F, et al. Annals of Oncology)
Discover additional QOL recommendations and guidance from the task force
Risk-Adapted Treatment Strategies for Older Patients with AML
Arellano M, et al. Cancer – In this review, the authors argue that the current treatment algorithm for older patients with acute myeloid leukemia (AML) ─ induction, followed by consolidation (with or without transplantation) versus hospice ─ is no longer sufficient.
Allogeneic HCT is Feasible for Patients Aged ≥70 Years
Al Malki MM, et al. Biol Blood Marrow Transplant – Patients aged 70 years and older undergoing reduced-intensity allogeneic HCT can achieve 2-year overall survival rates of 68%.
Frailty Assessments Can Inform Treatment Decisions in Patients with Hematologic Malignancies
Abel GA, et al. Blood – In this review, the authors outline how hematologists can make better treatment recommendations for their patients by incorporating several easy-to-use frailty assessment tools into their practice.
Study Shows Age Doesn't Affect Survival Outcomes in Patients with Non-Hodgkin Lymphoma Who Undergo Allogeneic HCT
Results from a retrospective study presented at the 2018 BMT Tandem Meetings dispute age as a limiting factor to transplant eligibility, showing no differences in 4-year outcomes for patients older or younger than age 65.
Measuring Frailty Can Improve Existing Prognostic Tools
Hegde A, et al. Bone Marrow Transplant – Because frailty is prevalent in many patients pre- and post-transplant and is associated with age-independent adverse transplant outcomes, the authors of this review recommend incorporating a frailty assessment to optimize the predictive ability of existing pre-transplant assessment (PTA) tools across all age groups and particularly in elderly individuals.
Disease Risk Index is Important Prognostic Factor for Older HCT Patients
He F, et al. Biol Blood Marrow Transplant – A study of 196 patients age 60-75 years with hematologic malignancies undergoing reduced-intensity conditioning (RIC) hematopoietic cell transplantation (HCT) has found that the Disease Risk Index (DRI) score is a significant prognostic factor for post-transplant relapse, treatment failure and mortality.
Older Patients with MDS: Uncovering Barriers to Allogeneic HCT
Getta BM, et al. Biol Blood Marrow Transplant – Only one-third of all patients with myelodysplastic syndromes (MDS) referred to an academic center undergo hematopoietic cell transplantation (HCT), according to a study of 362 patients with MDS treated at Memorial Sloan Kettering Cancer Center.
Improved Outcomes and Increased Use of HCT in Patients ≥70 Years
Muffly L, et al. Blood – Overall and progression-free survival after allogeneic hematopoietic cell transplantation (HCT) in patients ≥70 years with hematologic malignancies increased significantly between 2000 and 2013, according to a multi-center study.
Patients with MDS Responding to HMAs Have Better HCT Outcomes
Festuccia M, et al. Biol Blood Marrow Transplant – Patients with myelodysplastic syndromes (MDS) who undergo hematopoietic cell transplantation (HCT) while still responding to hypomethylating agents (HMAs) have lower rates of post-HCT relapse, according to a study of 125 patients with MDS.
Comorbidity Scores are Prognostic of Overall Survival in Relapsed/Refractory AML
Middeke JM, et al. Biol Blood Marrow Transplant – Comorbidity evaluations can provide clinically useful prognostic information at the time of diagnosis of relapsed or refractory acute myeloid leukemia (AML), according to results of a phase II trial.
Cytogenetic Risk Prognostic of HCT Outcomes in Older Patients with AML in CR2
Michelis FV, et al. Cancer – Allogeneic hematopoietic cell transplantation (HCT) is a curative treatment option for older patients with acute myeloid leukemia (AML) in second complete remission (CR2), particularly for those with favorable or intermediate cytogenetic risk, according to researchers who studied 169 transplants at 78 centers.
Allogeneic HCT is Feasible for Patients ≥70 Years
Sorror ML, et al. Biol Blood Marrow Transplant – New research presented at the BMT Tandem Meetings shows that patients aged 70 years and older can have comparable hematopoietic cell transplantation (HCT) outcomes to those of younger patients and that comorbidities and disease risks, not age, should be used to evaluate potential candidates.
Comparable HCT Survival and Incidence of Toxicity for Patients ≥60 Years
Shah GL, et al. ASH abstract oral presentation, December 2016 – Survival of patients ≥60 years undergoing ex vivo CD34+ selected reduced-intensity hematopoietic cell transplantation (HCT) was comparable to that of patients <60 years, according to research presented at ASH.
Careful Selection of Older Patients with MDS Can Improve HCT Outcomes
Heidenreich S, et al. Biol Blood Marrow Transplant – Researchers analyzing 313 patients over age 70 (median age 72 years) whose transplant outcomes were reported to the registry of the European Society for Blood and Marrow Transplantation (EBMT) found that careful selection of patients can significantly improve hematopoietic cell transplantation (HCT) outcomes.
Review: Advances in Allo-HCT Expand Use in Older Patients with NHL
Fenske TS, et al. Biol Blood Marrow Transplant – In this review, the authors present data supporting allogeneic HCT as a therapeutic option for patients with non-Hodgkin lymphoma (NHL) diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma focusing on patients over age 60.
Decision-Making Recommendations for Older Adults Considering HCT
Randall J, et al. Bone Marrow Transplant – This article outlines strategies to help older adults make an informed decision about transplantation, recognizing that older adults will likely have different functional and psychosocial considerations at this stage in life.
Increased Use of and Improved Survival in HCT for Patients ≥70 Years
Muffly L, et al. BMT Tandem Meetings abstract oral presentation, February 2016 – A study of 1,106 patients ≥70 years undergoing allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2013 has found that overall survival has improved significantly and use of HCT in this patient cohort has increased over the last decade.
Review: HCT for Patients with AML in First Complete Remission
Cornelissen JJ, et al. Blood – In this review, part of a Blood journal special review series on acute myeloid leukemia (AML), the authors note that although the majority of patients AML enter remission upon induction chemotherapy, the risk of relapse is considerable and it varies greatly according to age and genetic subtype.
Patients Age 65 Years and Older with MDS Should Not Be Limited from Undergoing HCT
Atallah E, et al. ASH abstract oral presentation, December 2015 – Patients over age 65 with myelodysplastic syndromes (MDS) should be considered transplant eligible, according to an oral presentation at the 2015 ASH Annual Meeting.
Meta-Analysis: Age Not a Determining Factor in HCT Selection for AML
Rashidi A, et al. Biol Blood Marrow Transplant – A meta-analysis of 749 patients >60 years undergoing hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML) has shown that older age per se should not be the sole criterion against selecting HCT therapy.
Low Non-Relapse Mortality, GVHD after HCT in Older Patients with AML in First Remission
Devine SM, et al. J Clin Oncol – A multi-center phase II study of 114 patients aged 60-74 years with AML in first remission has found that reduced-intensity HCT can lead to a low incidence of non-relapse mortality (NRM) and graft-versus-host disease (GVHD).
HCT Yields Best Outcomes in Patients ≥60 Years with AML
Versluis J, et al. Lancet Haematol – A study analyzing a series of four multi-center trials has shown significantly better 5-year overall survival for allogeneic hematopoietic cell transplantation (HCT) in patients aged 60 years and older with acute myeloid leukemia (AML) when compared with no and other post-remission therapies.
AML patients ≥70 Achieve 60% Estimated Survival with UCB HCT
Sandhu KS, et al. Biol Blood Marrow Transplant – In this single-center retrospective study of 22 transplant recipients 70 years and older, 10 patients undergoing umbilical cord blood (UCB) transplantation had an estimated 2-year overall survival of 60%.
Non-Myeloablative Haploidentical HCT in Older Patients
Kasamon YL, et al. J Clin Oncol – This retrospective, single-center study found that age had no significant effect on survival of 271 patients age 50-75 years undergoing non-myeloablative haploidentical hematopoietic cell transplantation (HCT).
Review: How I Treat the Older Patient with AML
Ossenkopple G, et al. Blood – In this installment of the "How I treat" series in Blood, the authors discuss the highly heterogeneous clinical biology of acute myeloid leukemia (AML) among patients and how those variations are relevant for prognosis and treatment choice.
Progress Report: Update of BMT CTN State of the Science Symposium
Ferrara JLM. Biol Blood Marrow Transplant – In this 2014 report, the author updates the status of the 11 hematopoietic cell transplantation (HCT) clinical trials identified as having the highest scientific priority at the 2007 State of the Science Symposium convened by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN).


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Preventing Youth Suicide
Written by Stan Adams
Jan 29, 2021 12:44:02 PM
Suicide is a serious public health problem among all age groups. Among youth it exacts an enormous toll due to the significant years of potential life lost. In 2017, there were more than 6,200 suicide deaths among adolescents and young adults ages 15-24, making it the second-leading cause of death for that age group.
This report is a somber one, but it is necessary to ensure you are aware of the situation.
The New York times recently reported on the surge of student suicides and how Las Vegas is pushing to reopen schools due to what has come to light.
We are all aware of the challenges we have individually faced dealing with the stress of social isolation and trying to cope. With
children, that stress is far stronger than we ever imagined.
Although the national data from 2020 is not yet available, youth emergency visits for mental health issues have skyrocketed across the nation.
In Clark County Arizona, the school system has seen a doubling of child suicides every 6 months since they went into lockdown.
The youngest suicide was 9 years old – his note read, "I have nothing to look forward to"
In Maryland, parents of a 14-year-old, described how he just gave up after the school chose not to reopen in the fall.
In Texas, Mr Hunstable produced a documentary called, "almost 13" to show his child's descent in social isolation that resulted in the hanging death of his son.
Child suicide rates were on the rise in the US even before the pandemic lockdown. In 2018, suicide was the leading cause of deaths for youths and young adults. With the growing social isolation and school closures, that number has spiked further in 2020. And since the lockdowns started, some districts have reported suicide clusters forming.
The situation is grim. Even when schools try to help by offering remote outreach services, those services are being overwhelmed by student calls for support. One school district has received over 3,100 alerts in a 3-month period. In each case of suicide, parents are left with grief and guilt, looking for signs they may have missed. As a parent who is on this devastating grief journey, I can assure you that this will haunt you for a very long time.
There are so many questions you ask yourself, with no comfort in the answers you uncover. Healthy Children. Org has 10 things a parent can do to prevent suicide. If you are a parent, grand parent or other childcare provider, I strongly encourage you to review the proactive steps you can take now, before it is too late.
Finally, the national suicide prevention lifeline number is 1-800-273-8255. Keep the number handy. They can also provide you help, if you believe someone to be at risk. Keep the number handy. They can also provide you help, if you believe someone to be at risk.
Until next time, stay vigilant and let's do all we can to reduce the spread.
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