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Project acronym 100 Archaic Genomes
Project Genome sequences from extinct hominins
Researcher (PI) Svante PÄÄBO
Summary Neandertals and Denisovans, an Asian group distantly related to Neandertals, are the closest evolutionary relatives of present-day humans. They are thus of direct relevance for understanding the origin of modern humans and how modern humans differ from their closest relatives. We will generate genome-wide data from a large number of Neandertal and Denisovan individuals from across their geographical and temporal range as well as from other extinct hominin groups which we may discover. This will be possible by automating highly sensitive approaches to ancient DNA extraction and DNA libraries construction that we have developed so that they can be applied to many specimens from many sites in order to identify those that contain retrievable DNA. Whenever possible we will sequence whole genomes and in other cases use DNA capture methods to generate high-quality data from representative parts of the genome. This will allow us to study the population history of Neandertals and Denisovans, elucidate how many times and where these extinct hominins contributed genes to present-day people, and the extent to which modern humans and archaic groups contributed genetically to Neandertals and Denisovans. By retrieving DNA from specimens that go back to the Middle Pleistocene we will furthermore shed light on the early history and origins of Neandertals and Denisovans.
Neandertals and Denisovans, an Asian group distantly related to Neandertals, are the closest evolutionary relatives of present-day humans. They are thus of direct relevance for understanding the origin of modern humans and how modern humans differ from their closest relatives. We will generate genome-wide data from a large number of Neandertal and Denisovan individuals from across their geographical and temporal range as well as from other extinct hominin groups which we may discover. This will be possible by automating highly sensitive approaches to ancient DNA extraction and DNA libraries construction that we have developed so that they can be applied to many specimens from many sites in order to identify those that contain retrievable DNA. Whenever possible we will sequence whole genomes and in other cases use DNA capture methods to generate high-quality data from representative parts of the genome. This will allow us to study the population history of Neandertals and Denisovans, elucidate how many times and where these extinct hominins contributed genes to present-day people, and the extent to which modern humans and archaic groups contributed genetically to Neandertals and Denisovans. By retrieving DNA from specimens that go back to the Middle Pleistocene we will furthermore shed light on the early history and origins of Neandertals and Denisovans.
Project acronym 2-HIT
Project Genetic interaction networks: From C. elegans to human disease
Researcher (PI) Ben Lehner
Host Institution (HI) FUNDACIO CENTRE DE REGULACIO GENOMICA
Summary Most hereditary diseases in humans are genetically complex, resulting from combinations of mutations in multiple genes. However synthetic interactions between genes are very difficult to identify in population studies because of a lack of statistical power and we fundamentally do not understand how mutations interact to produce phenotypes. C. elegans is a unique animal in which genetic interactions can be rapidly identified in vivo using RNA interference, and we recently used this system to construct the first genetic interaction network for any animal, focused on signal transduction genes. The first objective of this proposal is to extend this work and map a comprehensive genetic interaction network for this model metazoan. This project will provide the first insights into the global properties of animal genetic interaction networks, and a comprehensive view of the functional relationships between genes in an animal. The second objective of the proposal is to use C. elegans to develop and validate experimentally integrated gene networks that connect genes to phenotypes and predict genetic interactions on a genome-wide scale. The methods that we develop and validate in C. elegans will then be applied to predict phenotypes and interactions for human genes. The final objective is to dissect the molecular mechanisms underlying genetic interactions, and to understand how these interactions evolve. The combined aim of these three objectives is to generate a framework for understanding and predicting how mutations interact to produce phenotypes, including in human disease.
Most hereditary diseases in humans are genetically complex, resulting from combinations of mutations in multiple genes. However synthetic interactions between genes are very difficult to identify in population studies because of a lack of statistical power and we fundamentally do not understand how mutations interact to produce phenotypes. C. elegans is a unique animal in which genetic interactions can be rapidly identified in vivo using RNA interference, and we recently used this system to construct the first genetic interaction network for any animal, focused on signal transduction genes. The first objective of this proposal is to extend this work and map a comprehensive genetic interaction network for this model metazoan. This project will provide the first insights into the global properties of animal genetic interaction networks, and a comprehensive view of the functional relationships between genes in an animal. The second objective of the proposal is to use C. elegans to develop and validate experimentally integrated gene networks that connect genes to phenotypes and predict genetic interactions on a genome-wide scale. The methods that we develop and validate in C. elegans will then be applied to predict phenotypes and interactions for human genes. The final objective is to dissect the molecular mechanisms underlying genetic interactions, and to understand how these interactions evolve. The combined aim of these three objectives is to generate a framework for understanding and predicting how mutations interact to produce phenotypes, including in human disease.
Project acronym 2SEXES_1GENOME
Project Sex-specific genetic effects on fitness and human disease
Researcher (PI) Edward Hugh Morrow
Host Institution (HI) THE UNIVERSITY OF SUSSEX
Summary Darwin's theory of natural selection rests on the principle that fitness variation in natural populations has a heritable component, on which selection acts, thereby leading to evolutionary change. A fundamental and so far unresolved question for the field of evolutionary biology is to identify the genetic loci responsible for this fitness variation, thereby coming closer to an understanding of how variation is maintained in the face of continual selection. One important complicating factor in the search for fitness related genes however is the existence of separate sexes – theoretical expectations and empirical data both suggest that sexually antagonistic genes are common. The phrase "two sexes, one genome" nicely sums up the problem; selection may favour alleles in one sex, even if they have detrimental effects on the fitness of the opposite sex, since it is their net effect across both sexes that determine the likelihood that alleles persist in a population. This theoretical framework raises an interesting, and so far entirely unexplored issue: that in one sex the functional performance of some alleles is predicted to be compromised and this effect may account for some common human diseases and conditions which show genotype-sex interactions. I propose to explore the genetic basis of sex-specific fitness in a model organism in both laboratory and natural conditions and to test whether those genes identified as having sexually antagonistic effects can help explain the incidence of human diseases that display sexual dimorphism in prevalence, age of onset or severity. This multidisciplinary project directly addresses some fundamental unresolved questions in evolutionary biology: the genetic basis and maintenance of fitness variation; the evolution of sexual dimorphism; and aims to provide novel insights into the genetic basis of some common human diseases.
Darwin's theory of natural selection rests on the principle that fitness variation in natural populations has a heritable component, on which selection acts, thereby leading to evolutionary change. A fundamental and so far unresolved question for the field of evolutionary biology is to identify the genetic loci responsible for this fitness variation, thereby coming closer to an understanding of how variation is maintained in the face of continual selection. One important complicating factor in the search for fitness related genes however is the existence of separate sexes – theoretical expectations and empirical data both suggest that sexually antagonistic genes are common. The phrase "two sexes, one genome" nicely sums up the problem; selection may favour alleles in one sex, even if they have detrimental effects on the fitness of the opposite sex, since it is their net effect across both sexes that determine the likelihood that alleles persist in a population. This theoretical framework raises an interesting, and so far entirely unexplored issue: that in one sex the functional performance of some alleles is predicted to be compromised and this effect may account for some common human diseases and conditions which show genotype-sex interactions. I propose to explore the genetic basis of sex-specific fitness in a model organism in both laboratory and natural conditions and to test whether those genes identified as having sexually antagonistic effects can help explain the incidence of human diseases that display sexual dimorphism in prevalence, age of onset or severity. This multidisciplinary project directly addresses some fundamental unresolved questions in evolutionary biology: the genetic basis and maintenance of fitness variation; the evolution of sexual dimorphism; and aims to provide novel insights into the genetic basis of some common human diseases.
Project acronym 3CBIOTECH
Project Cold Carbon Catabolism of Microbial Communities underprinning a Sustainable Bioenergy and Biorefinery Economy
Researcher (PI) Gavin James Collins
Host Institution (HI) NATIONAL UNIVERSITY OF IRELAND GALWAY
Summary The applicant will collaborate with Irish, European and U.S.-based colleagues to develop a sustainable biorefinery and bioenergy industry in Ireland and Europe. The focus of this ERC Starting Grant will be the application of classical microbiological, physiological and real-time polymerase chain reaction (PCR)-based assays, to qualitatively and quantitatively characterize microbial communities underpinning novel and innovative, low-temperature, anaerobic waste (and other biomass) conversion technologies, including municipal wastewater treatment and, demonstration- and full-scale biorefinery applications. Anaerobic digestion (AD) is a naturally-occurring process, which is widely applied for the conversion of waste to methane-containing biogas. Low-temperature (<20 degrees C) AD has been applied by the applicant as a cost-effective alternative to mesophilic (c. 35C) AD for the treatment of several waste categories. However, the microbiology of low-temperature AD is poorly understood. The applicant will work with microbial consortia isolated from anaerobic bioreactors, which have been operated for long-term experiments (>3.5 years), and include organic acid-oxidizing, hydrogen-producing syntrophic microbes and hydrogen-consuming methanogens. A major focus of the project will be the ecophysiology of psychrotolerant and psychrophilic methanogens already identified and cultivated by the applicant. The project will also investigate the role(s) of poorly-understood Crenarchaeota populations and homoacetogenic bacteria, in complex consortia. The host organization is a leading player in the microbiology of waste-to-energy applications. The applicant will train a team of scientists in all aspects of the microbiology and bioengineering of biomass conversion systems.
The applicant will collaborate with Irish, European and U.S.-based colleagues to develop a sustainable biorefinery and bioenergy industry in Ireland and Europe. The focus of this ERC Starting Grant will be the application of classical microbiological, physiological and real-time polymerase chain reaction (PCR)-based assays, to qualitatively and quantitatively characterize microbial communities underpinning novel and innovative, low-temperature, anaerobic waste (and other biomass) conversion technologies, including municipal wastewater treatment and, demonstration- and full-scale biorefinery applications. Anaerobic digestion (AD) is a naturally-occurring process, which is widely applied for the conversion of waste to methane-containing biogas. Low-temperature (<20 degrees C) AD has been applied by the applicant as a cost-effective alternative to mesophilic (c. 35C) AD for the treatment of several waste categories. However, the microbiology of low-temperature AD is poorly understood. The applicant will work with microbial consortia isolated from anaerobic bioreactors, which have been operated for long-term experiments (>3.5 years), and include organic acid-oxidizing, hydrogen-producing syntrophic microbes and hydrogen-consuming methanogens. A major focus of the project will be the ecophysiology of psychrotolerant and psychrophilic methanogens already identified and cultivated by the applicant. The project will also investigate the role(s) of poorly-understood Crenarchaeota populations and homoacetogenic bacteria, in complex consortia. The host organization is a leading player in the microbiology of waste-to-energy applications. The applicant will train a team of scientists in all aspects of the microbiology and bioengineering of biomass conversion systems.
Project acronym 3D-OA-HISTO
Project Development of 3D Histopathological Grading of Osteoarthritis
Researcher (PI) Simo Jaakko Saarakkala
Host Institution (HI) OULUN YLIOPISTO
Summary "Background: Osteoarthritis (OA) is a common musculoskeletal disease occurring worldwide. Despite extensive research, etiology of OA is still poorly understood. Histopathological grading (HPG) of 2D tissue sections is the gold standard reference method for determination of OA stage. However, traditional 2D-HPG is destructive and based only on subjective visual evaluation. These limitations induce bias to clinical in vitro OA diagnostics and basic research that both rely strongly on HPG. Objectives: 1) To establish and validate the very first 3D-HPG of OA based on cutting-edge nano/micro-CT (Computed Tomography) technologies in vitro; 2) To use the established method to clarify the beginning phases of OA; and 3) To validate 3D-HPG of OA for in vivo use. Methods: Several hundreds of human osteochondral samples from patients undergoing total knee arthroplasty will be collected. The samples will be imaged in vitro with nano/micro-CT and clinical high-end extremity CT devices using specific contrast-agents to quantify tissue constituents and structure in 3D in large volume. From this information, a novel 3D-HPG is developed with statistical classification algorithms. Finally, the developed novel 3D-HPG of OA will be applied clinically in vivo. Significance: This is the very first study to establish 3D-HPG of OA pathology in vitro and in vivo. Furthermore, the developed technique hugely improves the understanding of the beginning phases of OA. Ultimately, the study will contribute for improving OA patients' quality of life by slowing the disease progression, and for providing powerful tools to develop new OA therapies."
"Background: Osteoarthritis (OA) is a common musculoskeletal disease occurring worldwide. Despite extensive research, etiology of OA is still poorly understood. Histopathological grading (HPG) of 2D tissue sections is the gold standard reference method for determination of OA stage. However, traditional 2D-HPG is destructive and based only on subjective visual evaluation. These limitations induce bias to clinical in vitro OA diagnostics and basic research that both rely strongly on HPG. Objectives: 1) To establish and validate the very first 3D-HPG of OA based on cutting-edge nano/micro-CT (Computed Tomography) technologies in vitro; 2) To use the established method to clarify the beginning phases of OA; and 3) To validate 3D-HPG of OA for in vivo use. Methods: Several hundreds of human osteochondral samples from patients undergoing total knee arthroplasty will be collected. The samples will be imaged in vitro with nano/micro-CT and clinical high-end extremity CT devices using specific contrast-agents to quantify tissue constituents and structure in 3D in large volume. From this information, a novel 3D-HPG is developed with statistical classification algorithms. Finally, the developed novel 3D-HPG of OA will be applied clinically in vivo. Significance: This is the very first study to establish 3D-HPG of OA pathology in vitro and in vivo. Furthermore, the developed technique hugely improves the understanding of the beginning phases of OA. Ultimately, the study will contribute for improving OA patients' quality of life by slowing the disease progression, and for providing powerful tools to develop new OA therapies."
Project acronym 3D-REPAIR
Project Spatial organization of DNA repair within the nucleus
Researcher (PI) Evanthia Soutoglou
Host Institution (HI) CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
Summary Faithful repair of double stranded DNA breaks (DSBs) is essential, as they are at the origin of genome instability, chromosomal translocations and cancer. Cells repair DSBs through different pathways, which can be faithful or mutagenic, and the balance between them at a given locus must be tightly regulated to preserve genome integrity. Although, much is known about DSB repair factors, how the choice between pathways is controlled within the nuclear environment is not understood. We have shown that nuclear architecture and non-random genome organization determine the frequency of chromosomal translocations and that pathway choice is dictated by the spatial organization of DNA in the nucleus. Nevertheless, what determines which pathway is activated in response to DSBs at specific genomic locations is not understood. Furthermore, the impact of 3D-genome folding on the kinetics and efficiency of DSB repair is completely unknown. Here we aim to understand how nuclear compartmentalization, chromatin structure and genome organization impact on the efficiency of detection, signaling and repair of DSBs. We will unravel what determines the DNA repair specificity within distinct nuclear compartments using protein tethering, promiscuous biotinylation and quantitative proteomics. We will determine how DNA repair is orchestrated at different heterochromatin structures using a CRISPR/Cas9-based system that allows, for the first time robust induction of DSBs at specific heterochromatin compartments. Finally, we will investigate the role of 3D-genome folding in the kinetics of DNA repair and pathway choice using single nucleotide resolution DSB-mapping coupled to 3D-topological maps. This proposal has significant implications for understanding the mechanisms controlling DNA repair within the nuclear environment and will reveal the regions of the genome that are susceptible to genomic instability and help us understand why certain mutations and translocations are recurrent in cancer
Faithful repair of double stranded DNA breaks (DSBs) is essential, as they are at the origin of genome instability, chromosomal translocations and cancer. Cells repair DSBs through different pathways, which can be faithful or mutagenic, and the balance between them at a given locus must be tightly regulated to preserve genome integrity. Although, much is known about DSB repair factors, how the choice between pathways is controlled within the nuclear environment is not understood. We have shown that nuclear architecture and non-random genome organization determine the frequency of chromosomal translocations and that pathway choice is dictated by the spatial organization of DNA in the nucleus. Nevertheless, what determines which pathway is activated in response to DSBs at specific genomic locations is not understood. Furthermore, the impact of 3D-genome folding on the kinetics and efficiency of DSB repair is completely unknown. Here we aim to understand how nuclear compartmentalization, chromatin structure and genome organization impact on the efficiency of detection, signaling and repair of DSBs. We will unravel what determines the DNA repair specificity within distinct nuclear compartments using protein tethering, promiscuous biotinylation and quantitative proteomics. We will determine how DNA repair is orchestrated at different heterochromatin structures using a CRISPR/Cas9-based system that allows, for the first time robust induction of DSBs at specific heterochromatin compartments. Finally, we will investigate the role of 3D-genome folding in the kinetics of DNA repair and pathway choice using single nucleotide resolution DSB-mapping coupled to 3D-topological maps. This proposal has significant implications for understanding the mechanisms controlling DNA repair within the nuclear environment and will reveal the regions of the genome that are susceptible to genomic instability and help us understand why certain mutations and translocations are recurrent in cancer
Project acronym 3D_Tryps
Project The role of three-dimensional genome architecture in antigenic variation
Researcher (PI) Tim Nicolai SIEGEL
Summary Antigenic variation is a widely employed strategy to evade the host immune response. It has similar functional requirements even in evolutionarily divergent pathogens. These include the mutually exclusive expression of antigens and the periodic, nonrandom switching in the expression of different antigens during the course of an infection. Despite decades of research the mechanisms of antigenic variation are not fully understood in any organism. The recent development of high-throughput sequencing-based assays to probe the 3D genome architecture (Hi-C) has revealed the importance of the spatial organization of DNA inside the nucleus. 3D genome architecture plays a critical role in the regulation of mutually exclusive gene expression and the frequency of translocation between different genomic loci in many eukaryotes. Thus, genome architecture may also be a key regulator of antigenic variation, yet the causal links between genome architecture and the expression of antigens have not been studied systematically. In addition, the development of CRISPR-Cas9-based approaches to perform nucleotide-specific genome editing has opened unprecedented opportunities to study the influence of DNA sequence elements on the spatial organization of DNA and how this impacts antigen expression. I have adapted both Hi-C and CRISPR-Cas9 technology to the protozoan parasite Trypanosoma brucei, one of the most important model organisms to study antigenic variation. These techniques will enable me to bridge the field of antigenic variation research with that of genome architecture. I will perform the first systematic analysis of the role of genome architecture in the mutually exclusive and hierarchical expression of antigens in any pathogen. The experiments outlined in this proposal will provide new insight, facilitating a new view of antigenic variation and may eventually help medical intervention in T. brucei and in other pathogens relying on antigenic variation for their survival.
Antigenic variation is a widely employed strategy to evade the host immune response. It has similar functional requirements even in evolutionarily divergent pathogens. These include the mutually exclusive expression of antigens and the periodic, nonrandom switching in the expression of different antigens during the course of an infection. Despite decades of research the mechanisms of antigenic variation are not fully understood in any organism. The recent development of high-throughput sequencing-based assays to probe the 3D genome architecture (Hi-C) has revealed the importance of the spatial organization of DNA inside the nucleus. 3D genome architecture plays a critical role in the regulation of mutually exclusive gene expression and the frequency of translocation between different genomic loci in many eukaryotes. Thus, genome architecture may also be a key regulator of antigenic variation, yet the causal links between genome architecture and the expression of antigens have not been studied systematically. In addition, the development of CRISPR-Cas9-based approaches to perform nucleotide-specific genome editing has opened unprecedented opportunities to study the influence of DNA sequence elements on the spatial organization of DNA and how this impacts antigen expression. I have adapted both Hi-C and CRISPR-Cas9 technology to the protozoan parasite Trypanosoma brucei, one of the most important model organisms to study antigenic variation. These techniques will enable me to bridge the field of antigenic variation research with that of genome architecture. I will perform the first systematic analysis of the role of genome architecture in the mutually exclusive and hierarchical expression of antigens in any pathogen. The experiments outlined in this proposal will provide new insight, facilitating a new view of antigenic variation and may eventually help medical intervention in T. brucei and in other pathogens relying on antigenic variation for their survival.
Project acronym 3DBIOLUNG
Project Bioengineering lung tissue using extracellular matrix based 3D bioprinting
Researcher (PI) Darcy WAGNER
Summary Chronic lung diseases are increasing in prevalence with over 65 million patients worldwide. Lung transplantation remains the only potential option at end-stage disease. Around 4000 patients receive lung transplants annually with more awaiting transplantation, including 1000 patients in Europe. New options to increase available tissue for lung transplantation are desperately needed. An exciting new research area focuses on generating lung tissue ex vivo using bioengineering approaches. Scaffolds can be generated from synthetic or biologically-derived (acellular) materials, seeded with cells and grown in a bioreactor prior to transplantation. Ideally, scaffolds would be seeded with cells derived from the transplant recipient, thus obviating the need for long-term immunosuppression. However, functional regeneration has yet to be achieved. New advances in 3D printing and 3D bioprinting (when cells are printed) indicate that this once thought of science-fiction concept might finally be mature enough for complex tissues, including lung. 3D bioprinting addresses a number of concerns identified in previous approaches, such as a) patient heterogeneity in acellular human scaffolds, b) anatomical differences in xenogeneic sources, c) lack of biological cues on synthetic materials and d) difficulty in manufacturing the complex lung architecture. 3D bioprinting could be a reproducible, scalable, and controllable approach for generating functional lung tissue. The aim of this proposal is to use custom 3D bioprinters to generate constructs mimicking lung tissue using an innovative approach combining primary cells, the engineering reproducibility of synthetic materials, and the biologically conductive properties of acellular lung (hybrid). We will 3D bioprint hybrid murine and human lung tissue models and test gas exchange, angiogenesis and in vivo immune responses. This proposal will be a critical first step in demonstrating feasibility of 3D bioprinting lung tissue.
Chronic lung diseases are increasing in prevalence with over 65 million patients worldwide. Lung transplantation remains the only potential option at end-stage disease. Around 4000 patients receive lung transplants annually with more awaiting transplantation, including 1000 patients in Europe. New options to increase available tissue for lung transplantation are desperately needed. An exciting new research area focuses on generating lung tissue ex vivo using bioengineering approaches. Scaffolds can be generated from synthetic or biologically-derived (acellular) materials, seeded with cells and grown in a bioreactor prior to transplantation. Ideally, scaffolds would be seeded with cells derived from the transplant recipient, thus obviating the need for long-term immunosuppression. However, functional regeneration has yet to be achieved. New advances in 3D printing and 3D bioprinting (when cells are printed) indicate that this once thought of science-fiction concept might finally be mature enough for complex tissues, including lung. 3D bioprinting addresses a number of concerns identified in previous approaches, such as a) patient heterogeneity in acellular human scaffolds, b) anatomical differences in xenogeneic sources, c) lack of biological cues on synthetic materials and d) difficulty in manufacturing the complex lung architecture. 3D bioprinting could be a reproducible, scalable, and controllable approach for generating functional lung tissue. The aim of this proposal is to use custom 3D bioprinters to generate constructs mimicking lung tissue using an innovative approach combining primary cells, the engineering reproducibility of synthetic materials, and the biologically conductive properties of acellular lung (hybrid). We will 3D bioprint hybrid murine and human lung tissue models and test gas exchange, angiogenesis and in vivo immune responses. This proposal will be a critical first step in demonstrating feasibility of 3D bioprinting lung tissue.


text:
Jean-Pierre Léon Bourjade (25. května 1889, Montauban – 22. října 1924, Papua Nová Guinea) byl sedmým nejúspěšnějším francouzským stíhacím pilotem první světové války s celkem 28 uznanými sestřely.

Byl druhým nejúspěšnějším specialistou na sestřelování balónů ze všech letců první světové války – z jeho 28 sestřelů bylo 27 balónů.

Během války získal mimo jiné tato vyznamenání: Légion d'honneur a Croix de Guerre.

Léon Bourjade zemřel v roce 1924 na Britské Nové Guineji, kde sloužil jako misionář.

Odkazy

Reference

Externí odkazy

  French Aces of WW1 - Léon Bourjade

Narození v roce 1889
Úmrtí v roce 1924
Francouzská letecká esa první světové války
Osobnosti první světové války
Francouzští stíhací piloti
Muži
Narození 25. května
Úmrtí 22. října
Nositelé Válečného kříže 1914–1918
Zemřelí na lepru
Důstojníci Řádu čestné legie

redpajama_set_name: RedPajamaWikipedia


Matthias Schoenaerts chats about his new film Far From The Madding Crowd, what true love really is and the best way to win someone over.
If he ever had a motto as an actor, his would be: 'Just go with the flow.' In fact, he actually throws in a reference to 'the flow' during our chat about his new film Far From The Madding Crowd, a gorgeously realised adaptation of Thomas Hardy's classic novel. For him acting is all about being spontaneous and in the moment.
His instinctive approach has paid off. Since his breakthrough performance as a steroid-addicted farmer in Bullhead (2011), the 36-year-old has proved himself to be an enthralling screen presence, captivating in his finely calibrated, mercurial intensity whether it's throwing punches in Rust and Bone (2012) or going completely batsh*t psycho in The Drop (2014). It's no wonder that he's been compared most often to Ryan Gosling and Marlon Brando. He communicates with the same brooding ferocity and imposing physicality.
Casting directors have sat up and taken note. Far From The Madding Crowd is the third film of his to come out in the space of two months following Suite Française and A Little Chaos. Directed by legendary Dogme 95 co-founder Thomas Vinterberg, it's a sweeping romance, handsomely shot with sun-dappled intimacy, which follows headstrong heroine, Bathsheba Everdene (Carey Mulligan), as she decides between three suitors; dependable shepherd Gabriel Oak (Schoenaerts), passionate soldier Frank Troy (Tom Sturridge) and wealthy farmer William Boldwood (Michael Sheen).
Gabriel, the archetypal nice guy, tries to woo the wilful Bathsheba by bringing her a lamb. He's pretty much immediately friend-zoned. Oak is a far cry from the tough guy roles that made Schoenaerts famous; for once there's no inner turmoil or darkness, he's just good through and through. He plays him with warm and dignified grace, smouldering with an earthy magnetism. It's obvious to everyone but her who Everdene should choose. As she flits between men trying to decide which one – if any – she really wants, he remains a steady presence in her life.
Mulligan is a formidable force as Bathsheba, full of impish mischief yet fiercely defiant. Schoenaerts calls the actress 'super devoted, determined and intelligent'. Her character is a feisty proto-feminist, who throws out lines like, 'It is difficult for a woman to define her feelings in language which is chiefly made by men to express theirs,' yet is betrayed by her own desires. But that's what makes her such a compelling character, just how erratic and contradictory she can be. Her struggle – how to maintain her own personality and independence as a woman while finding love – still feels relevant now.
Considering this and his last two films have been love stories, is Schoenaerts a softie at heart? 'Absolutely, yes, but I'm a lot of things that are not romantic as well,' he replies mysteriously. Not that Schoenaerts has to worry in that department. He's happily settled with his lawyer girlfriend Alexandra Schouteden in Antwerp and their two kittens. He has no plans to move to Hollywood even though he has a busy slate of films coming up.
He's been working on The Danish Girl, a film about transgender pioneer Einar Wegener, co-starring Eddie Redmayne and Alicia Vikander. He also recently completed A Bigger Splash, a tale of sexual intrigue and jealousy, and Close Protection about an ex-soldier with PTSD who is hired to protect the wife and child of a rich Lebanese businessman.
Spoken like a true romantic.


The meeting at MIRA Technology Park was arranged by Marcus Jones, MP for Nuneaton and Bedworth, supported by local MPs David Tredinnick (Bosworth), Alberto Costa (South Leicestershire) and Craig Tracey (North Warwickshire). Also present was Bill Cullen, Chief Executive of Hinckley and Bosworth Borough Council and Mark Ryder, Assistant Director of Transport at Warwickshire County Council, on behalf of the A5 Partnership.
Mr Grayling listened to key local concerns over the A5 as well as the work undertaken by the A5 Partnership in producing a strategy for its improvement. Discussion included the need for investment in priority sections of the road between the M42 and M69 and from the A5 to M6 via the A426.
Craig Tracey MP said, "The A5 clearly poses a number of challenges, with works needed to improve the situation not just now, but also ensure it is fit for the future".
David Tredinnick MP said, "I'm pleased the Secretary of State was sympathetic to the improvement strategy developed by the A5 Partnership and I hope that real progress can now be made in delivering the improvements that will benefit local people and businesses".
"As I have highlighted many times, the necessary improvements to this key road will also have a positive impact on the national economy and I commend the excellent work that has been undertaken by the A5 Partnership".
"It is significant that the Secretary of State has taken time to meet with senior council officers to understand the urgency about fixing the A5".


text:
UITextView+Placeholder
======================

[![CocoaPods](http://img.shields.io/cocoapods/v/UITextView+Placeholder.svg?style=flat)](http://cocoapods.org/?q=name%3AUITextView%2BPlaceholder)

A missing placeholder for UITextView.

Installation
------------

Use [CocoaPods](http://cocoapods.org).

```ruby
pod 'UITextView+Placeholder'
```

Usage
-----

Create `UITextView`, then set `placeholder`.

```objc
UITextView *textView = [[UITextView alloc] init];
textView.placeholder = @"How are you?";
textView.placeholderColor = [UIColor lightGrayColor]; // optional
```

Congratulations! You're done.

License
-------

UITextView+Placeholder is under MIT license. See LICENSE for more information.

redpajama_set_name: RedPajamaGithub


This is one of my early images and really cemented my love of Black & White imagery. It is also started my obsession with water imagery.
I loved the textures in both the flowing water and the crispness of the patterns in the granite rocks.
I still look at this image with fascination after all these years.


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The HEiKA Graduate School on "Functional Materials" is a central structural element of our Cluster. Aside the scientific research, the graduate school offers a module program preparing the doctoral researchers for a highly interdisciplinary research field.
In addition, annual Gordon-like conferences in rotating subfields of our Cluster, and annual retreats of the doctoral researchers are part of the Graduate School program. Furthermore, we regularly offer welcome and networking events.
The Graduate School's offer contributes to the continuous deepening of the partnerships and to the development of new cross-disciplinary connections between the PIs, PhD candidates and PostDocs from KIT and the Heidelberg University.
For more information on the Heidelberg Karlsruhe Strategic Partnership (HEiKA), please click here.


text:
package ca.farrelltonsolar.classic;

import android.app.Service;
import android.content.BroadcastReceiver;
import android.content.Context;
import android.content.Intent;
import android.content.IntentFilter;
import android.os.AsyncTask;
import android.os.Binder;
import android.os.IBinder;
import android.support.v4.content.LocalBroadcastManager;
import android.util.Log;

import java.io.File;
import java.util.ArrayList;
import java.util.List;
import java.util.Timer;

public class ModbusService extends Service {

    private final IBinder mBinder = new ModbusServiceBinder();

    private List<ModbusTask> tasks = new ArrayList<>();
    public ModbusService() {

    }

    @Override
    public int onStartCommand(Intent intent, int flags, int startId) {
        return Service.START_NOT_STICKY;
    }

    @Override
    public IBinder onBind(Intent arg0) {
        Log.d(getClass().getName(), "onBind");
        return mBinder;
    }

    @Override
    public File getCacheDir() {
        return super.getCacheDir();
    }

    public class ModbusServiceBinder extends Binder {
        ModbusService getService() {
            return ModbusService.this;
        }
    }

    @Override
    public void onCreate() {
        Log.d(getClass().getName(), "onCreate");
        super.onCreate();
        LocalBroadcastManager.getInstance(this).registerReceiver(removeChargeControllerReceiver, new IntentFilter(Constants.CA_FARRELLTONSOLAR_CLASSIC_REMOVE_CHARGE_CONTROLLER));
    }

    private BroadcastReceiver removeChargeControllerReceiver = new BroadcastReceiver() {
        @Override
        public void onReceive(Context context, Intent intent) {
            String uniqueId = intent.getStringExtra("uniqueId");
            for (ModbusTask task : tasks) {
                if (task.chargeController().uniqueId().compareTo(uniqueId) == 0) {
                    Disconnector d = new Disconnector(task);
                    d.executeOnExecutor(AsyncTask.THREAD_POOL_EXECUTOR);
                    break;
                }
            }
        }
    };

    @Override
    public void onDestroy() {
        Log.d(getClass().getName(), "onDestroy");
        LocalBroadcastManager.getInstance(this).unregisterReceiver(removeChargeControllerReceiver);
        stopMonitoringChargeControllers();
        super.onDestroy();
    }

    public void monitorChargeControllers(ChargeControllers controllers) {
        if (controllers == null || controllers.count() == 0) {
            return;
        }
        if (controllers.systemViewEnabled()) {
            int count = controllers.count();
            for (int i = 0; i < count; i++) {
                ChargeController controller = controllers.get(i);
                if (isBeingMonitored(controller) == false) {
                    ModbusTask task = new ModbusTask(controller, this.getBaseContext());
                    tasks.add(task);
                    Timer pollTimer = new Timer();
                    pollTimer.schedule(task, 100, Constants.MODBUS_POLL_TIME);
                    Log.d(getClass().getName(), String.format("Monitor running on: %s this thread is %s", controller.toString(), Thread.currentThread().getName()));
                }
            }
        }
        else {
            ChargeController controller = controllers.getCurrentChargeController();
            if (controller != null) {
                if (isBeingMonitored(controller) == false) {
                    stopMonitoringChargeControllers();
                    ModbusTask task = new ModbusTask(controller, this.getBaseContext());
                    tasks.add(task);
                    Timer pollTimer = new Timer();
                    pollTimer.schedule(task, 100, Constants.MODBUS_POLL_TIME);
                    Log.d(getClass().getName(), String.format("Monitor running on: %s this thread is %s", controller.toString(), Thread.currentThread().getName()));
                }
            }
        }
    }

    private boolean isBeingMonitored(ChargeController controller) {
        boolean rVal = false;
        for (ModbusTask task : tasks) {
            if (task.chargeController().equals(controller)) {
                rVal = true;
                break;
            }
        }
        return rVal;
    }

    public void stopMonitoringChargeControllers() {
        try {
            if (!tasks.isEmpty()) {
                for (ModbusTask task : tasks) {
                    Log.d(getClass().getName(), String.format("stopMonitoringChargeController: %s this thread is %s", task.chargeController().toString(), Thread.currentThread().getName()));
                    Disconnector d = new Disconnector(task);
                    d.executeOnExecutor(AsyncTask.THREAD_POOL_EXECUTOR);
                }
                tasks.clear();
            }
        }
        catch (Exception e) {
            e.printStackTrace();
        }
    }

    public Boolean isInService() {
        return !tasks.isEmpty();
    }

    private class Disconnector extends AsyncTask<String, Void, String> {

        private Disconnector(ModbusTask task) {
            this.task = task;
        }

        ModbusTask task;

        @Override
        protected String doInBackground(String... params) {
            Log.d(getClass().getName(), String.format("Cancelling task for: %s this thread is %s", task.chargeController().toString(), Thread.currentThread().getName()));
            task.cancel();
            task = null;
            return null;
        }
    }

}


text:
Q: Indent a string containing JSON like data I have a string like below:
   "{out: \"world\", out2: \"hello\", employee: {name: \"Singh\", emailid: \"simran@yahoo.com gur@yahoo.com\", address: {street_name: \"xxxxxx\", old_address: {old_street_name: \"xxxxxx\"}}, emp_code: \"12345678\"}, array2: [\"first\", \"second\"]}"

I want to get output as below. I did try using Json.MarshalIndent() here https://play.golang.org/p/uJbkNS00__k but it is returning same string back without indenting it.
{
  "out": "world",
  "out2": "hello",
  "employee":
     {
      "name": "Singh",
      "emailid": "simran@yahoo.com gur@yahoo.com",
      "address":
         {
           "street_name": "xxxxxx",
           "old_address":
             {
               "old_street_name": "xxxxxx"
             }
         },
      "emp_code": "12345678"
     },
   "array2": ["first","second"]
}

A: I think you can use below function with little changes to remove '\' from JSON like string and then unmarshal it.
func StripSlashes(s string) string {
    s = strings.Replace(s, "\", "", -1)
    return s
}

Next, you can parson JSON string with gjson library and use the gjson result. Or You can use the JSON.unmarshal(obj) from the stand Golang JSON library.

redpajama_set_name: RedPajamaStackExchange


I'm James, hello. This would take about 30 – 45 minutes of your time but could obviously be shorter if needed, you're a busy man/woman. It's usually pretty fun and silly, but if those two adjectives just made you a bit sick, don't worry, we could totally do 'awkward and funky' instead. I love interviewing and it's much more about having a chat with some daft questions for a while, rather than working out why acts do what they do, or how they do it.
You might be thinking at this point, 'hey, this all looks well and good, but what's your vibe? I only agree to things when I know the vibe of everyone involved' and I gotta say, it's pretty relaxed, I reckon. So that's that.
I'll absolutely get in touch with your people if you'd rather that's how we do this, I just wanted a place to explain the thing.
Thank you! Hope you're well. Oh and I'm lovely. Just, you know, as a person. In case you were wondering, and that was a deal breaker.
P.S. If you're worried that this seems a tad impersonal, and think I might just be sending it to everyone, don't worry. I'm only sending it to 'not as many as that'/people I'd really like to talk to. And if you would've rather that I mentioned your name a load of times in it, again, don't worry. I'll say your name when we record it. A LOT. If you agree, I'll never stop saying your name, baby..
OK, that bit got weird, and I apologise.


Within the secrets of the ateliers in Place Vendôme, our craftsmen seek to understand our clients and define their heart's desire in order to give life to their feelings in the form of an exceptional creation.
Placing a special order is a very unique experience in the great tradition of 'Bespoke service'. The Maison Boucheron artisans create a one-off piece, placing the customer at the heart of the creation of their piece of jewelry.


text:
Seven Wonders of Cities
On 01-15-15, Seven Wonders declared the winners for the Seven Wonders of Cities for the year 2015. You are invited to discover and explore these amazing cities. The original Seven Wonders of Cities was declared based on statitstical and traditional significance along with other polling. It is fair to say that statistical and traditional significance played a part for the new winners, but public voting determined the outcome for 2015.
The Seven Wonders of Cities is an annual declaration of the best city tourism destinations in the world. As noted above, the first collection of winning cities drew upon a variety of statistical factors, travel polls, iconic landmark representation and a few other characteristics. You were in charge of which cities won for 2015. Five of the original winners were there again, however there were two newcomers to the list for 2015.
Congratulations to each of these Seven Wonder Cities with a particular warm welcome to the two new cities of Tokyo and Singapore. Voting for the Wonder Cities of 2016 starts today, so after discovering the winners of 2015 take a moment and make your voice known with a vote for 2016.
Your next step: Vote for the Wonder Cities of 2016. Share, Tweet, Pin and spread the word getting friends, families, and your community involved to help determine the winners for 2016. Vote Here.
New York City was founded in 1624 and was originally named New Amsterdam. The name changed in 1664 when the city fell under English control with the city serving as the capital of the United States between 1785 and 1790.
London was founded by the Romans, and was given the name Londinium. The name London started serving as the name in the 19 th century. It is the capital city of England and the entire United Kingdom.
The first inhabitants of the city are dated back to 7500 BC. Then name "Paris" comes from the historical residential Celtic tribe group known as the Parisii, with the early name being Lutetia of the Parisii or Lutetia for short. Julian the Apostate renamed the city to Paris in the early 360s.
Tokyo is the capital of Japan, and as Tokyo Metropolis, it is one of the 47 prefectures of Japan. Tokyo serves as the location for the Japanese government as well as the Imperial Palace which is home to the Japanese Imperial Family.
Captain Arthur Phillip founded Sydney in 1788 at Sydney Cover as the original British territory within the Australian continent boundaries. No other iconic or wonder city can claim their origins as a penal colony.
Singapore, an island country, is a sovereign city-state. Located at the southern tip of the Malay Peninsula, the city-country island is surrounded by approximately 60 other smaller islands that comprise together to form the country of Singapore.
The original name of the city was Byzantium dating back to 660 BC. The name Istanbul, which translates "to the city," was officially adopted in 1930. Istanbul is located in the northwestern park of Turkey extending across 2,063 square miles (5,343 sq km). It is the 5 th most popular tourist destination in the world based on foreign visitors to the city.

redpajama_set_name: RedPajamaCommonCrawl


text:
From Shakespeare to Joyce
Roy Daniells
Volume 14, Number 2, January 1945
214 THE UNIVERSITY OF TORONTO QUARTERLY FROM SHAKESPEARE TO JOYCE~: Roy DANIELLS The mass of writing concerning Shakespeare-his life, his work, his times, his heroes, and ,his heroines-has long been an obstacle to more than ,intuitive appreciation of the plays. Many of us, shuddering at the corpus of Shakespearian criticism, decided early to find a way round rather than through it, and were later grateful when we discovered that Professor Stoll had cleared a path o'r two in the jungle by a process of simplification (which is not a simple process). He insists that the plays must be viewed objectively , in the achromatic light of the playwright's intention, and that this intention is the development of dramatic situation and npt the fabrication of characters which can be analysed as characters in real life. Such, with a variety of emphasis and the support of a polyglot erudition, has for more than a quarter-century 'been his theme. , The new book, From Shakespeare to joyce, is a continuation, or rather amplification, of Professor Stoll's previous work, and he is careful to establish the continuity. Here, as everywhere, he is 'the ideally rational and objective critic, of the school of Scherer. Works of literature, he insists , are not synonymous with life, not even with the lives of their authors; drama presents to its audience the emotional and the universal, embodied in stirring situations, at the cost of frequent divergence from the actual and violation of the probable. Shakespeare, Milton, and the plays of the Restor'ation again afford Professor Stoll materials for a convincing argument , in the course ofwhich familiar figures like Falstaff, Shylock, Jaques, and Belial take on a new objectivity. Objectivity, that is, in the sense ,that they are seen to be creatures of the stage, of the author's dramatic or epic intention: for this intention is Professor Stoll's polar star. He develops and elaborates the old lines: ' A perfect Judge will read each work of Wi t With the same spirit that its author writ. The,title of the book fails to indicate its thematic and polemic unity: three-quarters of it is devoted to showing conclusively that drama, reflecting the taste of its time rather than the time itself, is concerned first and last with situation even at the cost of probability. The title is also misleading in its implication that Professor Stoll is interested in contemporary writing. On the 'contrary, with gesture stern he repels "the present hapless era of- Unreason" a's a «revolutionary age"-including, it appears, most if not 'all of the' nineteenth century. To the establishment of his critical position Professor Stoll brings an intensely rational mind and a staggering scholarship (to the reader, that is: the author has the shoulders of Hercules). His erudite method, his sense of the autonomy of the work of art, his fine ear for qualities of style: , these are instruments which he employs in the grand strategy of his demon- *From Shakespeare to Joyce. By ELMER EDGAR STOLL. Garden City, New York: DO:Ibleday, Doran and Co. 1944. Pp. xxii, 442. ($3.50) REVIEWS 215 stration. His argument drives on over all cipposition bf Romantic critics and the reader is carried with it resistlessly "o'er shields, and helms, and helmed heads." An exception may be noted in the last three chapters: these present a mellow consideration of Milton's romanticism, of his handling of space and time, and of the ~eautiful1y graduated approach ,to the close of Paradise Lost. "Some natural tears" may be excused as the reader leaves this oasis. It is at chapter eighteen, on psychoanalysis in criticism;however, that the book really bursts open. The author has already given many proofs of his distrust ofthe modern (not to mention the strictly contemporary) world. If there is a good word for' the present century, I have not found it. "He loves LlS not." He d!slikes equally our realistic sordidness and our (ferment of sentimentality and humanitarianism"; faced with "modernizing tendencies " he can offer only correction and reproof. It is to be imagined, then, what happens when the subject is James Joyce as interpreted by 1\1r. Edmund...
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text:
History of Sailing
Ever since early sailors used square sails to help add speed to their oars, the sailboat has become increasingly more complex. The type of construction varied with the availability of materials. Wood was a common material, but was not available in areas like Lake Titicaca where the boats and sails both were constructed of reeds from the shoreline. When iron and steel became available, wood was replaced for the most part. And finally, the invention of steam removed sailing, for the most part, from daily shipping. Today sailing is enjoyed as recreational, and racing has become a very publicized event.
To understand modern theory, you must first look at the development of sailing in the working boats of old. Early developers knew that the speed of the boat was proportional to the size of the sail. They put huge sails on boats in efforts to speed shipping. Yet, the size of these sails were so large they became unmanageable without mass amounts of crew. Where labor was cheep, the Far East, huge sails were fitted, but for the rest of the world, a knew solution needed to be found. Sails became split into smaller units and ships carried more masts. Some ships had as many as seven masts and forty nine sails set at once.
Bit by bit, the sails evolved into triangles with moving points and arms that could turn, enabling people to sail upwind. From here we approach today. With computer assisted design and programs that can sail the boats before they are even made, we enter the twentieth century. One must realize that a sailboat may not sail at the wind and certain angles to the wind. This is called the luff zone. The efficiency of a boat in upwind situations can be determined by the angle at which the boat no longer gains forward momentum. The first sailboats had fixed sails and heavy improperly balanced ships.
They were very inefficient and slow. Today modern technology and mathematics join together to create boats that fit the formulas. Everything about to be described effects another characteristic of the boat's handling and capabilities. When talking of sailboats, buoyancy and stability are the first two areas of concern. With the force of high speeds, the boat must stand true in the water and move precisely. There are two "centers" of concern in a sailboat that should be described. These are areas where numerous forces exerted on the boat and rigging come together.
The center of effort, or CE, is the geometric center of the set sails. The center of effort is the balance point of the sails and is very important to the speed of the craft. Also, the center of lateral resistance (CLR) aids in proper sail trim and boat balance. This is the center of all underwater portions of the boat. Without these areas in balance, the drive, forward motion, of the boat would be lost. It was Archimedes who first saw that a boat would displace its own weight in water. Based on this, ratios developed based on various areas of underwater hull, and areas of cubes with the same dimensions.
The most important being the waterplane coefficient. This is the ration between the underwater plane of the boat and a rectangle having the same length and width. These along with various other, and more complicated, things help the boat remain afloat. Buoyancy is quite important, but of an even greater concern is the boat's stability. The stability is what gets the boat to stay up while the wind pounds at the sails. Here forces tend to play with the boat. Shown below are some of the major forces and how they act on the boat. The arrow showing righting lever force shows that the force is upward.
If the righting lever should for some reason shift, the boat becomes unstable and subject to roll over. Now that basic hydro-dynamics have been covered, the wind and sails are still left to discuss. Air moves in parallel streams that are very difficult to deflect. Low pressure air is far less dense than a high pressure area. A sail will achieve a low pressure area on the convex side giving it maximum lift. A sail is the same as a sideways airplane wing. On diagram A below, a sail is shown in its airstream. The air moves faster over the convex portion making a low pressure area.
Diagram B shows how the sail starts to lift and push forward when the wind flows across. A sail works much like the wing of an airplane. The sail is the same shape, but is vertical instead of horizontal. They obtain lift when force is applied. For a sailboat, this lift is transferred into forward motion by the shape of the hull. If the sail was not attached to the hull, the sail would move sideways. For the actual sails, any shape will work, but many sails have certain shapes to perform in various situations and conditions. Many boats today for round the world races like B. O. C. use asymmetrical sails that are cut for use on just one tack.
Storm sails are much baggier and heavier with less height to maximize drag and reduce drive. Light wind sails are tighter and bigger to harness every possible amount of wind. The forces the sail must overcome are important to the motion of the boat. In the theory of sail, four forces are exerted at 900 to each other. Diagram C shows the relationship and placement of the forces and their interaction. When any force exceeds drive, the boat will not move forward. Early sailors started splitting their large ineffective sails into smaller, better sails. By chance, many created a system where maximum drive was achieved during windward sailing.
The air flowing over the sail acts like that over a larger airfoil with a greater velocity. The air that moves between the sails, speeds up and improves the flow over the rear sail. A lot of the skill involved in racing performance is gauging the inter-relations between various types of sails. The keel is most probably the most important part of a sailboats forward momentum. The keel prevents sideways motion, drift. The keel produces a drag and drive from the flowing water and the angle of the keel in the water from the heeling boat produces side force or resistance.
A successfully designed and sailed boat balances these forces in such a way that there is a surplus of forward motion. Playing with the shapes of the keel and hull, we can obtain boats that perform for specific speeds, weather or even areas of the globe. Many boats today in around the world competitions, have winged keels. These keels were so secret at the beginning of the 1987 America's Cup, that the New Zealand team kept the boat covered during the weighting in. This keel is one of the three newest achievements in sailing technology. The fins slotting out allow the boat, when heeled to have a flat surface of keel in the water.
The second great invention in the sailing is the fixed wing sail. The testing had been on some smaller boats, but eventually ripped the course against the Kiwi's in the 1991 America's Cup. The fixed wing takes the "sideways airplane wing" analogy to the limit. Made of kevlar and other carbon compounds, this wing fired the American crew to a finish 17 minutes and 32 seconds before the New Zealand team. The wing along with the catamaran was so effective it beat its own predictions. It has long been assumed that no craft powered by the wind could exceed the speed of the wind that was powering it.
In mono-hull racing the fastest speeds were the Open 20 class who achieve around . 92 times the speed of the wind in 20 knot winds. The birth of a catamaran shattered these figures. With no deep, heavy keel and two narrow hulls, these boats can in effect "create wind. " They use the eddies created in front of the boat to add extra speed. Essentially, the cat's motion creates air disturbance that it then uses again along with the wind to move forward. The Super 18 Hobie has kevlar wings off of the hulls, enabling a crew to be far off the boat itself, and is the fastest boat available to the general public.
It achieves a surprising 1. 63 times the speed of the wind with a centered mast between the floats. Then a team from Stanford devised a new idea. They decided to fix sails on a boat with three hulls like diagram E. This boat is the current title holder as the fastest sailboat in the world. Technology effects everything from life and death procedures to the speed and handling of a sailboat. Science and sailing go hand in hand. With new alloys and carbon fiber compounds being found everyday sailing only has one way to go. The future holds new promises for lighter faster more exciting sailboats.
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If you are scheduled to have an MRI, CT scan or other imaging procedure, you need to make sure that you take the appropriate steps in order to get the safest and most accurate results. By following these tips, you can protect yourself from unnecessary radiation and an incorrect diagnosis.
Before you schedule your scan, you should talk to your doctor about why he thinks it is necessary. If you are concerned about the amount of radiation to which you will be exposed, then you may also want to discuss the different scans that are available and whether they will give your doctor the information he needs. If you are concerned about his answers to your questions, then do not hesitate to get a second opinion.
There are many places that will perform scans, but they are not all highly qualified. Choose a facility that is accredited with the American College of Radiology or its local counterpart in your country like the Philippine College of Radiology, and make sure that the radiologist is certified to perform the scans that have been ordered by your doctor. This will ensure that he is able to accurately perform and read the images that have been ordered, which will help your doctor to diagnose and treat your health issues.
Before you go to have your scan done, you should know how the procedure will be performed. Ask the radiologist or your doctor if a contrast agent will be used, which may require an injection. If you suffer from claustrophobia, you should talk to the facility about how they can help you relax as they get the images they need.
Once your doctor has received the images, you should make an appointment to learn more about what he has discovered. He should discuss the images with the radiologist and then explain the scans to you in a manner that is easy to understand. If the scans were inconclusive, your doctor may order other tests. You can also ask another doctor to review the images if you want a second opinion about the results. Radiologists and doctors may interpret the scans differently, and you may want a second medical professional to read the images.
Once your doctor has made a diagnosis, he will outline the treatment options that are available to you. During this discussion, you should ask if the results are conclusive and whether anything may have been missed when the radiologist first interpreted the images. This will help you decide whether you need to get a second opinion or further tests before you start your treatment plan.
If you are having health problems, your doctor may order radioactive scans in order to determine the best treatment options for your condition. You should always feel comfortable asking your doctor about his opinions, and he should be able to easily explain his findings so that you can better understand what your options may be. This will help you get the information you need to take control of your health so that you can start feeling better as soon as possible.
Yassin in an expert in health and wellness. He is employed at Brit Systems Inc., a company that provides digital medical imagery software to hospitals and clinics across the U.S.


The Office of Inspector General ("OIG") issued a Special Advisory Bulletin in June 2001 that alerts providers who engage the services of consultants to certain questionable practices employed or promoted by an unscrupulous few consultants that could result in providers making unnecessary expenditures or could expose them to potential legal liability. The bulletin, entitled "Practices of Business Consultants," encourages providers to recognize and protect themselves and the Medicare and Medicaid programs against these questionable practices.
The OIG recognizes that consultants–such as "accountants, attorneys, business advisors, and reimbursement specialists"–"play an integral role in developing and maintaining" programs that improve the efficiency and effectiveness of providers' operations while also improving the integrity of the health care system by enhancing the accuracy of the providers' claims and ensuring the providers' compliance with applicable laws, regulations, and rules. Instead of discouraging providers from engaging consultants, the bulletin purports to enlist providers' help in maximizing the potential value of consultants by purging the ranks of consultants of dishonest elements.
This article discusses each of these areas briefly in turn.
The bulletin warns that consultants may make illegal or misleading statements about their relationship with the Medicare program, the Centers for Medicare and Medicaid Services ("CMS"), or the OIG. For example, consultants may represent that their services or products are approved, certified, or recommended by Medicare, CMS, the Department of Health or Human Services, or the OIG. In fact, the OIG and other federal agencies do not recommend or endorse particular consultants or particular consultants' services. Alternatively, an educational consultant may represent that its Medicare reimbursement seminars are mandatory for obtaining or maintaining a Medicare provider number. In fact, the Medicare program does not require a provider to attend training courses in order to participate in the Medicare program.
The OIG cautions that consultants may expose providers to liability under the False Claims Act by promising specific, improbable results and then resorting to improper means–such as submitting false claims or preparing false cost reports on behalf of the provider–to effectuate these promises. For example, a billing consultant may promise that its advice or services will produce a specific dollar or percentage increase in the client's Medicare reimbursements. Providers ought to be wary of such promises, especially if the consultant proposes a fee arrangement which gives him a proprietary interest in the promised increased reimbursement–e.g., a contingent fee arrangement. The consultant might resort to submitting false claims on behalf of the provider in an attempt to secure the promised increased reimbursement.
While contingent fee arrangements are not illegal per se, providers and consultants should avoid contingent fee arrangements because they create the incentives that the OIG questions. Consultants should advise providers in the requirements for compliant and accurate documentation in all circumstances without regard to financial impact. Consultants should not have any incentive or opportunity to create the false claims that concerns the OIG.
The bulletin warns providers not to adopt recommendations that they engage in aggressive billing schemes or unreasonable practices that are fraudulent or abusive of the Medicare or Medicaid programs. It warns that "hiring a consultant does not relieve a provider of responsibility for ensuring the integrity of its dealings with the Federal health care programs." Thus, a provider ought to disregard recommendations that it use inappropriate billing codes in order to elevate reimbursement and methods to avoid detection; a provider should dismiss suggestions that it bill for an expensive item or service with a high reimbursement rate when a less expensive item or service with a lower reimbursement rate was actually provided to the patient; a provider should ignore suggestions that it create deceptive documentation in order to mislead potential reviewers.
Instead, providers should seek out the many competent and honest consultants who can help them to institute more complete and accurate documentation practices than they currently use. The providers are ultimately responsible for creating and verifying the truth of the documentation. Documentation and coding practices should strictly follow the Coding Clinic for ICD-9-CM, the definitive authority for Medicare coding issues.
The OIG cautions providers against heeding the advice of a consultant who tells them that they should not undertake certain compliance efforts (such as retrospective billing reviews) or that they should not cooperate with payer audits. The OIG makes clear that it believes that voluntary compliance efforts, such as internal auditing and self-review, are important tools for doing business with the Federal heath care programs. It suggests that providers can forestall fraud and abuse problems by engaging consultants who encourage and enable compliance efforts.
The OIG recognizes and approves of providers' use of consultants in helping them to comply with the complex web of laws and rules regulating the provision of health care. The Special Advisory Bulletin it issued in June 2001 constitutes its attempt to ensure that providers are vigilant in selecting and relying upon consultants.
Next post HIPAA Compliance: Where Are the Savings?


text:
Fall Arts: Where to spend your concert dollars
It's time to be thinking about where to put your hard-earned cash for advance purchases to avoid concert sell-out disappointment this fall.
There are two big touring seasons in the music industry: Summers feature the festival circuit, and see major acts hitting hot-spots all over the planet. Fall is reserved for arena tours in support of new releases, and a push by up-and-coming acts to try to get some of that sweet back-to-school action on college campuses. (It's not a coincidence so many tours coincide with the space of time between mid-terms and exams.)
With the changes to the music business bands only make their money on the road. That translates to a lot more shows than there used to be during the traditional December to March hump slowdown.
That means you need to be thinking about where to put your hard-earned cash for advance purchases to avoid sell out disappointment down the road. Here are our picks for this fall:
The Mainstream:
Sept. 29, 7 p.m. | BC Place
Tickets and info: From $169.50, at Ticketmaster.ca
The seventh world tour by this ridiculously huge UK group is in support of the namesake album A Head Full of Dreams, as well as the Kaleidoscope EP. All told, Chris Martin and the crew are playing 120 dates and all are in massive arenas. This, of course, means that there is going to be a lot of big lights, big pyro, big lasers, and the return of the incredibly popular light-emitting xyloband wristbands which made the Mylo Xyloto tour such a visual feast. Tove Lo and Alina Baraz open.
The Indie:
Deadmau5. Nathan Denette / THE CANADIAN PRESS
Oct. 24, 8 p.m. | Pacific Coliseum
Tickets and info: From $45.85, at ticketmaster.ca
Joel Thomas Zimmerman could probably walk down the street and not be spotted. When he is under his big-eared custom Deadmau5 headgear, he's one of the world's most popular DJs, and he's a savvy business man who has been releasing his music on his mau5trap label for over a decade. This production features old and new tunes, with the visual mayhem courtesy of the custom-designed Cube 2.1, an 18-foot (5.4 m) high rig that boasts bells, whistles, screens, decks, and the dude himself. Think arena rave action, and you are on the right path.
The Wild Card:
David Duchovny. NBC / Jim Fiscus/NBC
Oct. 14, 9 p.m. | Imperial, 319 Main
Tickets and info: From $25, at ticketweb.ca
The tune is out there. And the man who will be bringing it to listener's ears is former Vancouver regular and rain hater David Duchovny. Since the X-Files days, he has appeared in a number of hits ranging from Californication, to his turn as Dennis/Denise Bryson on Twin Peaks. The Yale writing graduate even penned his first novel, Holy Cow, in 2015 and watched it ride the New York Times bestsellers list. So when news arrived that he had completed his debut studio album for Think Say Records, folks wondered if he'd add hit musician to his list of achievements. With his laid-back, California country rock sound, this concert could be well worth a gander. And for superfans, there is a meet-and-greet VIP ticket package, too.
Read the latest Metro Vancouver arts news
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Dec 1 "Working for Equality: The Fight for Fair Pay and Equal Rights" Working Women of the 20th Century
Pia Subramaniam
December Issue '18
The East End Women's Museum is a public history project that aims to share and celebrate empowering and inspiring stories of women across east London.
Their project "Working for Equality: The Fight for Fair Pay and Equal Rights" explores the 50 years of struggle for working women in the UK during the 20th century, specifically looking at the women's factory history in Barking and Dagenham. The purpose of this project is to identify the threads that connect the suffragettes campaign during the First World War and the Ford strikes in 1968. During the wartimes in the 1910s and 1940s, it was very common for women to contribute as engineers, chemical analysts and industrial physicists. It was viewed by society as heroic and had been greatly praised. However, during the peacetime, especially the period right after the First and Second World War, working women were pressured by union leaders, politicians and employers into working in households again. They were steered away from the skilled, technical and management jobs and were made to do dull and repetitive work.
In 1920, benefit sanctions were introduced if a woman declined a domestic service job. Not only were these women directly steered into doing their, at the time, regular chores, but were dismissed or forced to resign if they got married or pregnant. Moreover, women that managed to continue to do their profession faced sexual harassment and discrimination. Women of colour experienced this even worse of course. They were also paid half the wage a man was.In 1968, Dagenham women sewing machinists were told that their work will be classified into Category B ("less skilled production jobs") instead of Category C ("more skilled production jobs"). Moreover, in that category, they were going to be paid 15% less than men. It was very common to pay women less, regardless of the hard skills involved. Sewing machinists striking for equal pay in the streets of London.
Thus, on June 7, 1968, women sewing machinists at the Ford motor factory in Dagenham held a strike on the streets of London for equal pay. It ended three weeks later and immediately resulted in an increase in their pay rate by just 8% below that of men. In the following year, their job was classified into the Category B. And in 1970, the Ford Dagenham sewing machinist's strike inspired the most important event in the history of women's rights activism, the passing of the Equal Pay Act. The Act eliminated unequal treatment and pay between men and women. Unfair pay was merely a part of the struggles working women faced during the 20th century. By the end of the 19th century, in several countries women had gained the right to vote. However, Britain was not one of them. Thus, in 1903, Emmeline Pankhurst formed the Women's Social and Political Union (WSPU), a women-only movement that rebelled against the injustice and unequal rights towards them, specifically the right to vote. The WSPU began the suffragette campaign. Members of the WSPU organisation holding their iconic banner "Votes for Women". The term "suffragettes" referred to the rebellious members of this group who actively fought for women's right to vote in public elections.
During the campaign, the suffragettes attempted to storm the parliament, battled with the police and vandalised the buildings and streets in demonstration for equal rights. The members were attacked and sexually assaulted by the police and were hated and ridiculed by the media. In 1914, the campaign had been brought to a halt when the First World War began. But after the war the Representation of the People Act was passed and gave women over the age of 30 who had certain qualifications the right to vote. And with the Representation of the People (Equal Franchise) Act passed in 1928, all women over 21 gained the right. 2018 is the 50th anniversary of the Ford Dagenham sewing machinist's strike that inspired the Equal Pay Act. The machinists also motivated women trades unionists to hold an "equal pay demonstration" in Trafalgar Square in 1969. And the suffragettes campaign triggered the electoral equality with men. These milestones have become important symbols of the 20th century women's activism. Today, they are considered sources of local pride, especially in east London.
This is damning evidence that it is indeed possible for us to make a change and to gain equality and justice. It is possible to move a nation, to help pass a revolutionary law and make the world a better place. As the WSPU motto was: "deeds, not words", we need to do the work ourselves and take direct action in the strong belief that we have the ability to make that change.
Because as history proves, we can.
Feb 1 BAFTA Nominations 2019: Where are the Female Directors?
Dec 1 Rachel Maclean at Zabludowicz Collection
Mar 1 Feminism
Jun 1 The Evolution of Swimwear


Dissolve salt in water, add flour, sprinkle yeast on top. In a stand mixer with dough hook attachment, mix on lowest speed until incorporated then continue on this speed for 8 minutes. Let rest 20 minutes to relax then scrape into greased 10 x 14 black steel pan (or 9 x 13), spread, cover with plastic wrap, & place in refrigerator over night. The dough will be very wet. This is ok.
Remove pan from refrigerator 2 - 3 hours before baking and place in a warm area to rise.
Preheat oven to 460 degrees. Uncover the dough and bake the dough for 2 - 3 minutes. Remove from oven and top with sauce, mozzarella, & sharp cheddar. Sprinkle the Parmigiano Reggiano around the edges to create the crispy edges. Top with toppings of your choice.
Continue baking for another 10-12 minutes or until golden.
Carefully slide pizza from pan and on to a cooling rack for a couple minutes.
Never had Detroit style pizza. Been making homemade pizza for years, and done more experimenting than you would believe. I have to admit, the dough recipe had me more than a little concerned. Turned out great. Thank you for posting...we really enjoyed it.
Fond memories of Buddy's. I'll let you know how it comes out. Thanks for posting.
Yes! Good recipe. I live very close to a Buddy's and we don't get their pizza often enough. That crunchy crust is pretty much unmatched.


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We are monitoring the impact of COVID-19 on Europe Disposable Medical Devices Sensors Market Get in touch with us for detailed analysis Know More
Europe Disposable Medical Devices Sensors Market
Europe Disposable Medical Devices Sensors Market R . . . .
Europe Disposable Medical Devices Sensors Market Research Report – Segmented By Type, Placement of Sensors, Application, Therapeutics, Patient Monitoring, Imaging Devices, End-User & Country (UK, France, Spain, Germany, Italy, Russia, Sweden, Denmark, Switzerland, Netherlands, Turkey, Czech Republic & Rest of Europe) - Industry Analysis on Size, Share, Trends & Growth Forecast (2021 to 2026)
Europe Disposable Medical Devices Sensors Market Size (2021 to 2026)
The size of the Europe Disposable Medical Devices Sensors Market was valued at USD 2.09 billion in 2021. It is further estimated to be growing at a CAGR of 10.8% and value USD 3.49 billion by 2026.
The high incidence of diseases (chronic/acute) is one of the major factors driving the market. In addition, an increase in hospital visits and hospitalization rates is increasing the widespread use of devices such as sphygmomanometer cuffs, x-ray nozzles, thermometers, catheters, and stethoscopes in hospitals market growth. Over the past two decades, nosocomial infections (HAIs) have become a significant challenge for hospitals and the medical community due to cross-infection by contaminated medical devices either for diagnosis or therapeutics. According to the CDC, up to 1.5 million hospital patients suffer from hospital-acquired infections each year. In Germany, it is estimated that between 400,000 and 600,000 patients each year suffer from a nosocomial infection, with between 10,000 and 15,000 resulting in death due to complications. Typical problems for health care providers are surgical site infections, urinary tract infections, and pneumonia, especially among newborns and other hospitalized patients. 33% of all HAIs in the country are urinary tract infections, 23% are surgical site infections, 16% are pneumonia, and 15% are blood infections. Ultimately, these numbers are expected to increase, resulting in high morbidity and mortality rates, long hospital stays, and improved patient and healthcare costs.
In addition, stringent government regulations for patient safety and overall healthcare and R&D activities, high healthcare spending, and higher incidence of chronic diseases, especially cardiovascular and neurological diseases, will be responsible for strengthening the outlook for the European disposable medical device sensors market during the forecast period.
However, strict government regulations for certification and product approvals may challenge the market growth rate. Furthermore, data security and privacy have become of great concern to patients and healthcare providers due to the increasing proliferation and adoption of IoT-based connected medical devices. This gives a chance for data theft and threats for cyber-attacks coupled with patient personal information leakage. This is a major factor restraining the growth of the European disposable medical device sensors market.
This research report on the European disposable medical device sensors market has been segmented and sub-segmented into the following categories:
By Placement of Sensors:
Invasive Sensors
Wearable Sensors
Implantable Sensors
Strip Sensors
Ingestible Sensors
Pregnancy Test Strip Sensors
Drug and Alcohol Test Strip Sensors
HIV Test Strip Sensors
By Therapeutics:
Dialysis Device Sensors
Cardiac Therapy Devices
Cardiac Catheter Sensors
Insulin Pump Sensors
By Patient Monitoring:
Continuous Blood Pressure Monitors
Cardiac Monitors
Continuous Glucose Monitoring (CGM) Devices
Implantable Loop Recorders
Smart Pills
By Imaging Devices:
Capsule Endoscope Sensors
Disposable Endoscope Sensors
By End User:
Geographically, Europe was the second-largest market, after North America, in terms of health care. Health spending has grown faster than economic growth in Europe. By 2030, health spending in Europe is expected to increase by 6.5% and represent between 12% and 16% of the total EU GDP. In 2019, Germany accounted for the largest market share of 31%, followed by the UK, Spain, France, and Italy. The regional market is anticipated to grow with a well-developed healthcare sector, investments in public institutions and government grants, and large patient populations. These facts are expected to benefit the market in Germany during the forecast period.
Innovations and the availability of a range of sensors for medical devices improve healthcare quality, efficiency, and safety in European regions. Although the breach of data poses a threat, key manufacturers of the disposable medical devices sensor aim to follow high standards to ensure the confidentiality and security of patient data. This is anticipated to provide opportunities to many regional markets especially in Denmark, Sweden, and Poland.
However, the regional market in Italy is projected to increase with the highest CAGR during the forecast period. The regional government is committed to providing quality health care at an affordable price by adopting new therapies and advanced diagnostics, which will drive the market in this region.
KEY MARKET PLAYERS:
Companies that dominate the European disposable medical device sensors market profiled in the report are Medtronic plc., Philips Healthcare, Analog Devices, Inc., GE Healthcare, Smiths Medical, Honeywell International STMicroelectronics, Freescale Semiconductors, Inc., Omnivision Technologies, Inc., and Sensirion AG.
5.1.2 Biosensors
5.1.3 Accelerometers
5.1.4 Image sensors
5.1.5 Pressure sensors
5.1.6 Temperature sensors
5.1.10 Market Share Analysis, By Type
5.2 Placement of Sensors
5.2.2 Invasive sensors
5.2.3 Wearable Sensors
5.2.4 Implantable sensors
5.2.5 Strip sensors
5.2.6 Ingestible sensors
5.2.7 Y-o-Y Growth Analysis, By Placement of Sensors
5.2.8 Market Attractiveness Analysis, By Placement of Sensors
5.2.9 Market Share Analysis, By Placement of Sensors
5.3.2 Diagnostics
5.3.2.1 Blood Glucose Test Strips
5.3.2.2 Pregnancy Test Strip Sensors
5.3.2.3 Drug and Alcohol Test Strip Sensors
5.3.2.4 HIV Test Strip Sensors
5.3.3 Therapeutics
5.3.3.1 Dialysis Device Sensors
5.3.3.2 Cardiac Therapy Devices
5.3.3.3 Cardiac Catheter Sensors
5.3.3.4 Insulin Pump Sensors
5.3.4 Patient Monitoring
5.3.4.1 Continuous Blood Pressure Monitors
5.3.4.2 Pulse Oximeters
5.3.4.3 Cardiac Monitors
5.3.4.4 Continuous Glucose Monitoring (CGM) Devices
5.3.4.5 Implantable Loop Recorders
5.3.4.6 Smart Pills
5.3.4.7 Others
5.3.5 Imaging devices
5.3.5.1 Capsule Endoscope Sensors
5.3.5.2 Disposable Endoscope Sensors
5.3.6 Y-o-Y Growth Analysis, By Application
5.3.7 Market Attractiveness Analysis, By Application
5.3.8 Market Share Analysis, By Application
5.4 End-user
5.4.3 Laboratories
5.4.4 Home based
5.4.5 Y-o-Y Growth Analysis, By End-user
5.4.6 Market Attractiveness Analysis, By End-user
5.4.7 Market Share Analysis, By End-user
6.1.3.3 By Placement of Sensors
6.1.3.4 By Application
6.1.3.5 By End-user
Segment-level analysis in terms of technology, component, and type along with market size forecasts and estimations to detect key areas of industry growth in detail
Europe Disposable Medical Device Sensors Market, By Type, From 2021 to 2026 (USD Billion)
Europe Biosensors Market, By Region, From 2021 to 2026 (USD Billion)
Europe Accelerometers Market, By Region, From 2021 to 2026 (USD Billion)
Europe Image sensors Market, By Region, From 2021 to 2026 (USD Billion)
Europe Pressure sensors Market, By Region, From 2021 to 2026 (USD Billion)
Europe Temperature sensors Market, By Region, From 2021 to 2026 (USD Billion)
Europe Others Market, By Region, From 2021 to 2026 (USD Billion)
Europe Disposable Medical Device Sensors Market, By Placement of Sensors, From 2021 to 2026 (USD Billion)
Europe Invasive sensors Market, By Region, From 2021 to 2026 (USD Billion)
Europe Wearable Sensors Market, By Region, From 2021 to 2026 (USD Billion)
Europe Implantable sensors Market, By Region, From 2021 to 2026 (USD Billion)
Europe Strip sensors Market, By Region, From 2021 to 2026 (USD Billion)
Europe Ingestible sensors Market, By Region, From 2021 to 2026 (USD Billion)
Europe Disposable Medical Device Sensors Market, By Application, From 2021 to 2026 (USD Billion)
Europe Diagnostics Market, By Region, From 2021 to 2026 (USD Billion)
Europe Therapeutics Market, By Region, From 2021 to 2026 (USD Billion)
Europe Patient Monitoring Market, By Region, From 2021 to 2026 (USD Billion)
Europe Imaging devices Market, By Region, From 2021 to 2026 (USD Billion)
Europe Disposable Medical Device Sensors Market, By End-User, From 2021 to 2026 (USD Billion)
Europe Hospitals Market, By Region, From 2021 to 2026 (USD Billion)
Europe Laboratories Market, By Region, From 2021 to 2026 (USD Billion)
Europe Home based Market, By Region, From 2021 to 2026 (USD Billion)
U.K. Disposable Medical Device Sensors Market, By Type, From 2021 to 2026 (USD Billion)
U.K. Disposable Medical Device Sensors Market, By Placement of Sensors, From 2021 to 2026 (USD Billion)
U.K. Disposable Medical Device Sensors Market, By Application, From 2021 to 2026 (USD Billion)
U.K. Disposable Medical Device Sensors Market, By End-User, From 2021 to 2026 (USD Billion)
Germany Disposable Medical Device Sensors Market, By Type, From 2021 to 2026 (USD Billion)
Germany Disposable Medical Device Sensors Market, By Placement of Sensors, From 2021 to 2026 (USD Billion)
Germany Disposable Medical Device Sensors Market, By Application, From 2021 to 2026 (USD Billion)
Germany Disposable Medical Device Sensors Market, By End-User, From 2021 to 2026 (USD Billion)
France Disposable Medical Device Sensors Market, By Type, From 2021 to 2026 (USD Billion)
France Disposable Medical Device Sensors Market, By Placement of Sensors, From 2021 to 2026 (USD Billion)
France Disposable Medical Device Sensors Market, By Application, From 2021 to 2026 (USD Billion)
France Disposable Medical Device Sensors Market, By End-User, From 2021 to 2026 (USD Billion)
Italy Disposable Medical Device Sensors Market, By Type, From 2021 to 2026 (USD Billion)
Italy Disposable Medical Device Sensors Market, By Placement of Sensors, From 2021 to 2026 (USD Billion)
Italy Disposable Medical Device Sensors Market, By Application, From 2021 to 2026 (USD Billion)
Italy Disposable Medical Device Sensors Market, By End-User, From 2021 to 2026 (USD Billion)
Spain Disposable Medical Device Sensors Market, By Type, From 2021 to 2026 (USD Billion)
Spain Disposable Medical Device Sensors Market, By Placement of Sensors, From 2021 to 2026 (USD Billion)
Spain Disposable Medical Device Sensors Market, By Application, From 2021 to 2026 (USD Billion)
Spain Disposable Medical Device Sensors Market, By End-User, From 2021 to 2026 (USD Billion)
Disposable Medical Devices Sensors Market


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Doghouse Reports
Watch Dog Report
Dead Athlete's Brain Scan Shows Signs of CTE
Disturbing Discovery in Dead LEGEND – It's Terrible
(WatchDogReport.org) – There probably isn't a single NFL fan who hasn't cringed at the sight of a quarterback (QB) getting leveled with a blindside sack or a wide receiver (WR) on a crossing pattern meeting up with a defensive back (DB) with a loud "CRACK!" that can be heard throughout the stadium. These hits often lead to concussions, and players who repeatedly suffer these injuries are prone to develop chronic traumatic encephalopathy (CTE). Former Denver Broncos star WR Demaryius Thomas, who died suddenly on December 9, 2021, is the latest to have been diagnosed with the syndrome.
Doctors have posthumously diagnosed Demaryius Thomas as having Stage 2 CTE when he died in December, per Ken Belson.
The official cause of his death is yet to be determined. pic.twitter.com/z8zl74Z6XT
— Bleacher Report (@BleacherReport) July 5, 2022
CTE can have a brutal impact on players and their families as it can cause memory loss, difficulty thinking, emotional instability, and increased aggression. Thomas's father describes watching his son fall deeper into his paranoia, saying it had gotten so bad he never saw his child leave home without a gun in the months before his death.
Determining who may be at risk for the condition is proving nearly impossible for researchers who have found the only way to diagnose it is by examining the brain during an autopsy, or other postmortem inspection. One study done by the Players Association (NFLPA) found that there were on average 247 concussions per year in the years 2015 to 2019, which does not include sub-concussive hits that can cause brain injuries that don't meet the criteria for a concussion.
Do you think there needs to be more safety precautions to hopefully prevent CTE in future players?
Copyright 2022, WatchDogReport.org
Ilhan Omar May Survive House Purge by the GOP
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Hope you had a wonderful Thanksgiving! I am back on track with a new modem/router and functioning wifi - that is until the FCC takes away Net Neutrality with the expected vote on December 22. There will be a national day of demonstrations for Net Neutrality on Thursday, December 7.
Item 23. Surveillance Technology Ordinance.