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CHEMISTRY AND THERAPEUTIC EFFECTS OF ANALGESICS
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PROJECT TOPIC AND MATERIAL ON CHEMISTRY AND THERAPEUTIC EFFECTS OF ANALGESICS
Name:CHEMISTRY AND THERAPEUTIC EFFECTS OF ANALGESICS
This work, Chemistry and Therapeutic Effects of Analgesics is an effort to bring together various works which has been done about drugs with analgesic properties, comparison of their effectiveness to pain management and the chemistry associated to pain. It also seeks to bring to the interest of a chemist, the import of application of a specialize knowledge such as chemistry to preparing selected analgesics, showing latent potency of chemical knowledge in solving the problem of various types of pain, with relatively less cost.
The effectiveness of analgesics cannot be over-emphasized; hence this work to an extent reveals the broad world of analgesic and enclosed it with such truth as how it's been chemistry all along even to the therapeutic nature of these analgesics.
What is an analgesic?
An analgesic, known colloquially as a painkiller, is any natural or synthetic drug that relieves pain (produces analgesia) without causing loss of consciousness, paralysis, or other major impairment of sensory function or nerve impulse conduction. It is different from anesthetics, which produces anesthesia i.e. relives pain by causing loss of consciousness.The word analgesic derives from Greek an- ("without") and -algia ("pain"). The term analgesia refers to an absence of the sensation of pain while still being conscious.
Morphine is a highly-potent opiate analgesic and is the principal active agent in opium and the prototypical opioid.
An analgesic is any member of a diverse group of drugs used to relieve pain. The type of analgesic used depends on the severity of pain; whether it is acute (self-limiting in duration, such as childbirth) or chronic (lasting more than three months) and the response to other medications (Uretsky 2002). However the World Health Organization's "pain ladder," originally developed for cancer-related pain, is a widely used protocol for determining in a stepwise manner the suitable drug and dosage for treating pain (WHO, 1990). The choice of analgesia is also determined by the type of pain: for neuropathic pain, traditional analgesia is less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants (Dworkin et al. 2003). Analgesic drugs act in various ways on the peripheral (PNS) and central nervous systems (CNS), either blocking the signal from the PNS or distorting the interpretation by the CNS (Uretsky 2002).
Medical researchers have developed widely diverse compounds for treating pain, including some synthetic opioids that produce an analgesic effect but that are much less likely to induce dependency. It is important to note that some pain is productive, acting as a warning of injury and a guide to diagnosis and treatment; thus it is also important to realize that while analgesics relieve symptoms, they do not affect the underlying cause (Uretsky 2002).
REVIEW OF MAJOR CLASSIFICATIONS OF ANALGESICS
There are two basic classifications of analgesics: Opioids or Narcotic analgesics and Nonopioids analgesics.
Opiod Analgesics; its history and natural sources
A sample of raw opium
The term "opioid" originated in the 1950s. It combines "opium" + "-oid" meaning "opiate-like" ("opiates" being morphine and similar drugs derived from opium). The first scientific publication to use it, in 1963, included a footnote stating, "In this paper, the term, 'opioid', is used in the sense originally proposed by George H. Acheson (personal communication) to refer to any chemical compound with morphine-like activities". By the late 1960s, research found that opiate effects are mediated by activation of specific molecular receptors in the nervous system, which were termed "opioid receptors". The definition of "opioid" was later refined to refer to substances that have morphine-like activities that are mediated by the activation of opioid receptors. One modern pharmacology textbook states: "the term opioid applies to all agonists and antagonists with morphine-like activity, and also the naturally occurring and synthetic opioid peptides". Another pharmacology reference eliminates the morphine-like requirement: "Opioid, a more modern term, is used to designate all substances, both natural and synthetic, that bind to opioid receptors (including antagonists)". Some sources define the term opioid to exclude opiates, and others use opiate comprehensively instead of opioid, but opioid used inclusively, is considered modern, preferred and is in wide use (Offermanns and Stefan 2008).
Natural opioids occur in 2 places:
In the juice of the opium poppy (morphine and codeine)
As endogenous endorphins.
All other opioids are prepared from either morphine (semi synthetic opioids such as heroin) or they are synthesized from precursor compounds (synthetic opioids such fentanyl, hydrocodone, oxycodone).
The terms opiate and narcotic are sometimes encountered as synonyms for opioid. Opiate is properly limited to the natural alkaloids found in the resin of the opium poppy although some include semi-synthetic derivatives. Narcotic, derived from words meaning numbness or sleep, as an American legal term, refers to cocaine and opioids, and their source materials; it is also loosely applied to any illegal or controlled psychoactive drug. In other jurisdictions all controlled drugs are legally classified as narcotics. The term can have pejorative connotations and its use is generally discouraged where that is the case.
Primarily used for pain relief, including anesthesia they are also used to suppress cough, suppress diarrhea, treat addiction, reverse opioid overdose, and suppress opioid induced constipation. Extremely strong opioids are approved only for veterinary use such as immobilizing large mammals. Opioids act by binding to opioid receptors, which are found principally in the central and peripheral nervous system and the gastrointestinal tract. These receptors mediate both the psychoactive and the somatic effects of opioids. Opioid drugs include partial agonists and antagonists, which produce moderate or no effect (respectively) but displace other opioids from binding in those receptors.
For the purpose of this study, emphasis will be later laid on the control of abuse of opium derivatives; the role of the government agencies.
The Opioid Analgesics
Opioid analgesics, known also as "narcotic analgesics," are analgesics derived from opium, as well as semi-synthetics and even synthetics that behave pharmacologically like morphine, and are pain relievers that act on the central nervous system (Uretsky 2002; Ross-Flanigan 2002). The archetypal opioid is morphine, a derivative of the opium poppy. The morphine molecule is the chemical basis of many painkillers, some with minimal abuse potential (Uretsky, 2002). In addition to morphine, other narcotic analgesics include codeine, oxycodone, propoxyphene (Darvon), hydrocodone, and diacetylmorphine (heroin, meperidine (Demerol), and pethidine). All exert a similar influence on the cerebral opioid receptor system. Tramadol and buprenorphine are thought to be partial agonists of the opioid receptors.
Opium is a narcotic formed from the latex (i.e., sap) released by lacerating (or "scoring") the immature seed pods of opium poppies (Papaver somniferum). The opium latex contains up to 16 percent morphine, as well as codeine and non-narcotic alkaloids, such as papaverine and noscapine (Ross-Flanigan, 2002). Heroin (diacetylmorphine or diamorphine) is a semi-synthetic opioid synthesized from morphine. As with other opiates, heroin can act both as a painkiller and a recreational drug.
Codeine is an alkaloid found in opium. While it can be extracted from opium, most codeine is synthesized from morphine through the process of O-methylation. Codeine is by far the most widely used opiate in the world and very likely most commonly used drug overall.
Opioids, while very effective analgesics may have some unpleasant side-effects. Drowsiness, dizziness, and breathing problems are some unwanted side effects, as well as physical and mental dependence (Ross-Flanigan, 2002). Like all narcotics, opioids can become habit-forming. In addition, up to one in three patients starting morphine may experience nausea and vomiting (generally relieved by a short course of antiemetics). Pruritus (itching) may require switching to a different opioid. Constipation occurs in almost all patients on opioids, and laxatives (lactulose, macrogol-containing or co-danthramer) are typically co-prescribed.
Dosing of all opioids may be limited by opioid toxicity (confusion, respiratory depression, myoclonic jerks and pinpoint pupils), but there is no dose ceiling in patients who tolerate this.
When used appropriately, opioid analgesics are otherwise safe and effective. However, risks such as addiction and the body becoming used to the drug are serious concerns. Due to the body getting used to the drug, often the dose must be increased. If the drug is being used for treating a chronic disease, the doctor may follow the pattern of the no ceiling limit. What must be remembered, however, is that although there is no upper limit there is still a toxic dose even if the body has become used to lower doses. Frequent administration of heroin has a high potential for causing addiction and may quickly lead to tolerance. If a continual, sustained use of heroin for as little as three days is stopped abruptly, withdrawal symptoms can appear. This is much shorter than the withdrawal effects experienced from other common painkillers such as oxycodone and hydrocodone.
1.5 Other Classifications of opiod
Naturalopiates: alkaloids contained in the resin of the opium poppy, primarily morphine, codeine, and thebaine, but not papaverine and noscapine which have a different mechanism of action; The following could be considered natural opiates: The leaves from Mitragyna speciosa (also known as kratom) contain a few naturally-occurring opioids, active via Mu- and Delta receptors. Salvinorin A, found naturally in the Salvia divinorum plant, is a kappa-opioid receptor agonist.
Esters of morphineopiates: slightly chemically altered but more natural than the semi-synthetics, as most are morphine prodrugs, diacetylmorphine (morphine diacetate; heroin), nicomorphine (morphinedinicotinate),dipropanoylmorphine (morphinedipropionate,desomorphine, acetylpropionylmorphine, dibenzoylmorphine, diacetyldihydromorphine.
Semi-syntheticopioids: created from either the natural opiates or morphine esters, such as hydromorphone,hydrocodone, oxycodone, oxymorphone, ethylmorphine and buprenorphne;
Fully syntheticopioids: such as fentanyl, pethidine, levorphanol, methadone, tramadol and dextropropoxyphene;
Endogenousopioid peptides, produced naturally in the body, such as endorphins, enkephalins, dynorphins, and endomorphins. Morphine, and some other opioids, which are produced in small amounts in the body are included in this category.
Tramadol and tapentadol, which act as monoamine uptake inhibitors also act as mild and potent agonists (respectively) of the μ-opioid receptor. Both drugs produce analgesia even when naloxone, an opioid antagonist, is administered.
Some minor opium alkaloids and various substances with opioid action are also found elsewhere, including molecules present in kratom, Corydalis, and Salvia divinorum plants and some species of poppy aside from Papaver somniferum. There are also strains which produce copious amounts of the baine, an important raw material for making many semi-synthetic and synthetic opioids. Of all of the more than 120 poppy species, only two produce morphine.
Amongst analgesics there are a small number of agents which act on the central nervous system but not on the opioid receptor system and therefore have none of the other (narcotic) qualities of opioids although they may produce euphoria by relieving pain—a euphoria that, because of the way it is produced, does not form the basis of habituation, physical dependence, or addiction. Foremost amongst these are nefopam, orphenadrine, and perhapsphenyltoloxamine and/or some other antihistamines. Tricyclic antidepressants have pain killing effect as well, but they're thought to do so by indirectly activating the endogenous opioid system.
Other analgesics work peripherally (i.e., not on the brain or spinal cord). Research is starting to show that morphine and related drugs may indeed have peripheral effects as well, such as morphine gel working on burns. Recent investigations discovered opioid receptors on peripheral sensory neurons. A significant fraction (up to 60%) of opioid analgesia can be mediated by such peripheral opioid receptors, particularly in inflammatory conditions such as arthritis, traumatic or surgical pain. Inflammatory pain is also blunted by endogenous opioid peptides activating peripheral opioid receptors.
1.6 Opium alkaloids
Many of the alkaloids and other derivatives of the opium poppy are not opioids or narcotics; the best example is the smooth-muscle relaxant papaverine. Noscapine is a marginal case as it does have CNS effects but not necessarily similar to morphine, and it is probably in a category all its own.
For the purpose of this study, a small list of few opium alkaloid is made. Though Phenanthrene is naturally occurring in (opium):
Codeine
Thebaine
Oripavine
The side effects of opioids may include itchiness, sedation, nausea, respiratory depression, constipation, and euphoria although these side effects will be treated later in details. Tolerance and dependence also develop with continuous use, requiring increasing doses and leading to a withdrawal syndrome upon abrupt discontinuation. The euphoria attracts recreational use, and frequent, escalating recreational use of opioids typically results in addiction. Accidental overdose or concurrent use with other depressant drugs commonly results in death from respiratory depression. Because of opioid drugs' reputation for addiction and fatal overdose, most are highly controlled substances (World Drug Report, 2015). Illicit production, smuggling, and addiction to opioids prompted treaties, laws and policing which have realized limited success. In 2013 between 28 and 38 million people used opioids illicitly (0.6% to 0.8% of the global population between the ages of 15 and 65). 2011 an estimated 4 million people in the United States used opioids recreationally or were dependent on them. Current increased rates of recreational use and addiction are attributed to over-prescription of opioid medications and inexpensive illicit heroin. Conversely, fears about over-prescribing, exaggerated side effects and addiction from opioids are similarly blamed for under-treatment of pain.
Non-clinical use was criminalized in the U.S by the Harrison Narcotics Tax Act of 1914, and by other laws worldwide. Since then, nearly all non-clinical use of opioids has been rated zero on the scale of approval of nearly every social institution. However, in United Kingdom the 1926 report of the Departmental Committee on Morphine and Heroin Addiction under the Chairmanship of the President of the Royal College of Physicians reasserted medical control and established the "British system" of control—which lasted until the 1960s; in the U.S. the Controlled Substances Act of 1970 markedly relaxed the harshness of the Harrison Act.
Before the twentieth century, institutional approval was often higher, even in Europe and America. In some cultures, approval of opioids was significantly higher than approval of alcohol. Opiates were used to treat depression and anxiety until the mid-1950s
NONOPIOIDS
The two main classes of nonopioids are the nonsteroidal anti-inflammatory drugs (NSAIDs), including the salicylates, and acetaminophen (paracetamol).The NSAIDs also have antipyretic and anti-inflammatory effects; they reduce fever and inflammation. Acetaminophen is a non-narcotic analgesic that lacks anti-inflammatory effects.
THE NSAIDs
NSAIDs are analgesics with antipyretic and anti-inflammatory effects. The term "non-steroidal" is used to distinguish these drugs from steroids, which (among a broad range of other effects) have a similar eicosanoid-depressing, anti-inflammatory action. The most prominent members of this group of drugs are aspirin, ibuprofen, and naproxen partly because they are available over-the-counter in many areas.
Aspirin and the other NSAIDs inhibit cyclooxygenase, leading to a decrease in prostaglandin production; this reduces pain and also inflammation (in contrast to acetaminophen and the opioids).
Beginning in 1829, with the isolation of salicin from the folk remedy willow bark, NSAIDs have become an important part of the pharmaceutical treatment of pain (at low doses) and inflammation (at higher doses). Part of the popularity of NSAIDs is that, unlike opioids, they do not produce sedation or respiratory depression and have a very low addiction rate. NSAIDs, however, are not without their own problems. NSAIDs predispose to peptic ulcers, renal failure, and allergic reactions.
Certain NSAIDs, including ibuprofen and aspirin, have become accepted as relatively safe and are available over-the-counter without prescription. The use of certain NSAIDs in children under 16, suffering from viral illness may contribute to Reye's syndrome.
COX-2 inhibitors
These drugs have been derived from NSAIDs. The cyclooxygenase enzyme inhibited by NSAIDs was discovered to have at least two different versions: COX1 and COX2. Research suggested that most of the adverse effects of NSAIDs were mediated by blocking the COX1 (constitutive) enzyme, with the analgesic effects being mediated by the COX2 (inducible) enzyme. The COX2 inhibitors were thus developed to inhibit only the COX2 enzyme (traditional NSAIDs block both versions in general). These drugs (such as rofecoxib and celecoxib) are equally effective analgesics when compared with NSAIDs, but cause less gastrointestinal hemorrhage in particular. However, post-launch data indicated increased risk of cardiac and cerebrovascular events with these drugs due to an increased likelihood of clotting in the blood due to a decrease in the production of protoglandin around the platelets causing less clotting factor to be released, and rofecoxib was subsequently withdrawn from the market. The role for this class of drug is hotly debated. Illnesses inadvertently caused by doctors and medical treatments, called iatrogenic diseases, are possible when the treatment affects the patient's blood, respiration, digestive processes and other bodily functions and organs.
1.9 THE ACETAMINOPHEN
Acetaminophen or paracetamol (International Nonproprietary Name) is a popular analgesic and antipyretic (fever-reducing) drug that is used for the relief of headaches, fever, and minor aches and pains, such as pain in joints and muscles. Paracetamol is predominantly a centrally acting analgesic (non-narcotic) which mediates its effect by action on descending serotoninergic (5-hydroxy triptaminergic) pathways, to increase 5-HT release (which inhibits release of pain mediators). It also decreases cyclo-oxygenase activity. It has recently been discovered that most or all the therapeutic efficacy of paracetamol is due to a metabolite AM404, making paracetamol a prodrug) which enhances the release of serotonin and also interacts with the cannabinoid receptors by inhibiting the uptake of an andamide.
Acetaminophen or paracetamol is a major ingredient in numerous cold and flu medications and many prescription analgesics. When used responsibly in standard doses, it is considered effective and safe, but because of its wide availability and narrow therapeutic index, accidental or deliberate overdoses are not uncommon. Excessive doses lead to hepatotoxicity (liver damage).
Acetaminophen is an organic compound that inhibits synthesis of prostagladins in the central nervous system, thus raising the body's pain threshold, and further impacts the temperature-regulating center of the brain, thus reducing fever. Its exact mechanism is still poorly understood. Since it lacks anti-inflammatory properties, it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs. In normal doses, acetaminophen is less likely than NSAIDs to irritate the lining of the stomach and cause peptic ulcers, and does not affect blood coagulation, the kidneys, or the fetal ductu arteriosus (as NSAIDS can). It is a possible alternative for people allergic to NSAIDs or who are using anticoagulants.
OTHER ANALGESIC AGENTS
In patients with chronic or neuropathic pain, various other substances may have analgesic properties, but are not typically classified as analgesics. Tricyclic antidepressants, especially amitriptyline, have been shown to improve pain in what appears to be a central manner. The exact mechanism of carbamazepine, gabapentin, and pregabalin is similarly unclear, but these anticonvulsants are used to treat neuropathic pain with modest success.
MECHANISM OF ACTION AND EFFECTS OF NONOPIOID ANALGESIC
The primary mechanism of action of NSAIDs is inhibition of the enzyme cyclooxygenase (COX), resulting in blockade of prostaglandin synthesis. Acetaminophen, another nonopioid, appears to act mostly via a central mechanism. All nonopioids have anti-inflammatory, antipyretic, and analgesic effects, but the anti-inflammatory effect of acetaminophen is essentially negligible. The analgesic effect of NSAIDs is prompt (minutes to hours), whereas the anti-inflammatory effect may take longer (1-2 weeks or longer). This latter effect can indirectly relieve some pain by reducing tissue swelling. The relatively recent discovery that COX has at least two isoforms, COX-1 and COX-2, has advanced NSAID pharmacology. COX-1 is constitutively expressed in most normal tissues, but plays an especially important role in the gastrointestinal (GI) tract, kidneys, and platelets; COX-1 primarily produces prostaglandins with beneficial effects (e.g., regulation of blood flow to the gastric mucosa and kidneys). In contrast, COX-2 is normally not present but may be induced in response to inflammatory stimuli; COX-2 primarily produces prostaglandins that activate and sensitize nociceptors. Nonselective NSAIDs inhibit COX-1 and COX-2, which contributes to both their therapeutic actions and side effects. Agents that selectively inhibit COX-2 were introduced to minimize the risk of GI side effects without compromising analgesic efficacy. The "coxibs" affect COX-2 both centrally and peripherally.
However, an increased risk of myocardial infarction, stroke, and death has been linked to selective COX-2 inhibitors, and this increased risk of cardiovascular side effects appears to be a class effect of NSAIDs, including nonselective agents. Rofecoxib and valdecoxib were voluntarily withdrawn from the market in 2004 and 2005, respectively, because of these cardiovascular safety concerns. Celecoxib is still available because its benefits appear to outweigh its potential risks in certain patients. A third COX isoform, COX-3, recently was identified. There is evidence that inhibition of COX-3 represents the primary central mechanism by which acetaminophen relieves pain.
Other classification of Nonopioids Analgesic with examples includes:
(A) Based on chemical nature-
(I) Non-Selective COX Inhibitors-Salicylic acid derivatives e.g. Aspirin, Sodium salicylate.
– Para-amino phenol derivatives e.g. Acetaminophen.
– Indol and Indane acetic acids e.g. Indomethacin, Sulindac.
– Heteroaryl acetic acids e.g. Tolmetin, Diclofenac, Keterolac.
– Aryl propionic acids e.g. Ibuprofen, Naproxen, Flurbiprofen, Ketoprofen, Fenoprofen, Oxaprofen.
– Anthranilic acids e.g. Mefenamic acid, Meclofenamic acid.
– Enolic acids (Oxicams) e.g. Piroxicam, Meloxicam, Tenoxicam, Isoxicam.
– Alkanones e.g. Nabumetone.
(II) Selective COX-2 Inhibitors
– Indole acetic acids e.g. Etodolac.
– Sulfonanilides e.g. Nimesulide.
– Diaryl substituted furanones e.g. Rofecoxib.
– Diaryl substituted pyrazoles e.g. Celecoxib.
(B) Based on mode of inhibition of COX-
Class I: Simple, competitive reversible inhibition that competes with arachidonic acid for binding to the COX site e.g. Ibuprofen, Piroxicam, Sulindac, Meclofenamic acid and Naproxen.
Class II: Competitive, time dependent reversible inhibitors that bind to the COX active site in the first phase to form reversible enzyme inhibitor complex e.g. Flurbiprofen, Diclofenac
Class III: Competitive, time dependent, irreversible inhibitors that form an enzyme inhibitor complex e.g. Aspirin
(C) On the basis of selective inhibition of COX
(I) Selective COX inhibitors
– Salicylates Acetylated: Aspirin.
Non acetylated: Salsalate, Trisalycilate.
– Nonsalicylates.
(2) Non selective COX-1/COX-2 or Traditional NSAIDs: Ibuprofen, Indomethacin, Neproxen, Silindac, Ketoprofen, Ketorolac, Fenoprofen, Diclofenac, Piroxicam, Oxaprazin
(3) Semi selective NSAIDs: Meloxicam, Etodolac, Nabumatone.
(4) COX-2 selective Inhibitor: Celecoxib, Rofecoxib, Enterocoxib.
SPECIFIC FORMS AND USES OF ANALGESICS
Analgesics are frequently used in combination, such as the acetaminophen and codeine preparations found in many non-prescription pain relievers. Propoxyphene and acetaminophen are used together (Darvocet N), as are oxydodone and acetaminophen (Percocet, Roxicet), and hydrocodone and acetaminophen (Lortab, Anexsia) (Ross-Flanigan 2002). Analgesics also can be found in combination with vasoconstrictor drugs such as pseudoephedrine for sinus-related preparations, or with antihistamine drugs for allergy sufferers.
The use of acetaminophen (paracetamol), as well as aspirin, ibuprofen, naproxen, and other NSAIDs concurrently with weak to mid-range opiates (up to about the hydrocodone level) has been shown to have beneficial synergistic effects by combating pain at multiple sites of action—NSAIDs reduce inflammation that in some cases, is the cause of the pain itself while opiates dull the perception of pain. Thus, in cases of mild to moderate pain caused in part by inflammation, it is generally recommended that the two be prescribed together (Mehlisch 2002).
Topical or systemic Analgesics
Topical analgesia is generally recommended to avoid systemic side-effects. Painful joints, for example, may be treated with an ibuprofen– or diclofenac-containing gel; capsaicin also is used topically. Lidocaine, an anesthetic, and steroids may be injected into painful joints for longer-term pain relief. Lidocaine is also used for painful mouth sores and to numb areas for dental work and minor medical procedures.
Psychotropic agents
Tetrahydrocannabinol (THC) and some other cannabinoids, either from the Cannabis sativa plant or synthetic, have analgesic properties, although the use of cannabis derivatives is illegal in many countries. Other psychotropic analgesic agents include ketamine (an NMDA receptor antagonist), clonidine and other α2-adrenoreceptor agonists, and mexiletine and other local anaesthetic analogues.
Atypical and/or adjuvant analgesics
Orphenadrine, cyclobenzaprine, scopolamine, atropine, gabapentin, first-generation antidepressants, and other drugs possessing anticholinergic and/or antispasmodic properties are used in many cases along with analgesics to potentiate centrally acting analgesics such as opioids when used against pain especially of neuropathic origin and to modulate the effects of many other types of analgesics by action in the parasympathetic nervous system. Dextromethorphan has been noted to slow the development of tolerance to opioids and exert additional analgesia by acting upon the NMDA receptors; some analgesics such as methadone and ketobemidone and perhaps piritramide have intrinsic NMDA action.
The use of adjuvant analgesics is an important and growing part of the pain-control field and new discoveries are made practically every year. Many of these drugs combat the side effects of opioid analgesics—an added bonus. For example, antihistamines, including orphenadrine, combat the release of histamine caused by many opioids; methylphenidate, caffeine, ephedrine, dextroamphetamine, and cocaine and work against heavy sedation and may elevate mood in distressed patients as do the antidepressants.
Examples of Nonopioid Analgesics
ENHANCING THE PROPERTIES OF COAL BRIQUETTE USING SPEAR GRASS (IMPERATA CYLINDRICA) AND ELEPHANT GRASS (PENNISETUM PURPUREUM)
REMEDIATION OF Cr (VI) FROM CONTAMINATED WATER BY ACTIVATED CARBON ENTRAPPED IN CALCIUM ALGINATE BEADS
EXTRACTION_AND_CHARACTERIZATION_OF_VEGETABLE_OIL_USING_BREAD_FRUIT_SEED


A membership is an economical way to boat at a fraction of the cost of boat ownership. The table above illustrates the first year itemized costs between a membership and purchasing a $25,000 boat. These numbers do not include cleaning, travel time, or hauling a boat.


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Q: SQL Server : joining the users table to match the matching column employee number I am running a query to show the users name from the users table to the tickets table requester_id, submitter_id, and assignee_id to add a name column behind it like below:
  ,t.requester_id
  ,u.name as requester_name
  ,t.submitter_id
  ,u.name as submitter_name
  ,t.assignee_id
  ,u.name as assignee_name

If I only do the requester_name and join join Users as u on t.requester_id = u.ID it works. But I am trying to do this to three columns.
SELECT t.id
 ,t.url
 ,t.external_id
 ,t.type
 ,t.subject
 ,t.description
 ,t.priority
 ,t.status
 ,t.recipient
 ,t.requester_id
 ,u.name as requester_name
 ,t.submitter_id
 ,u.name as submitter_name
 ,t.assignee_id
 ,u.name as assignee_name
 ,t.organization_id
 ,t.group_id
 ,t.collaborator_ids
 ,t.forum_topic_id
 ,t.problem_id
 ,t.has_incidents
 ,t.due_at
 ,t.tags
 ,t.via
 ,t.custom_fields
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FROM Tickets as t
join Users as u on t.requester_id = u.ID
join Users as u on t.submitter_id = u.ID
join Users as u on t.assignee_id = u.ID

I am trying to add a new row after each requester_id, submitter_id, and assignee_id to show the name after it from the users table.
Any help would be greatly appreciated.

A: You are halfway there, by joining to the Users table three times, but you need to give it a different alias each time:
FROM Tickets as t
join Users as ru on t.requester_id = ru.ID
join Users as su on t.submitter_id = su.ID
join Users as au on t.assignee_id = au.ID

Then:
  ,t.requester_id
  ,ru.name as requester_name
  ,t.submitter_id
  ,su.name as submitter_name
  ,t.assignee_id
  ,au.name as assignee_name

redpajama_set_name: RedPajamaStackExchange


International Airport, Long Island Rail Road trains and New York City Subway.
car facilities, hotel shuttles, and airport parking lots.
to long term parking lots A and B and to airport employee parking.
Jamaica Long Island Railroad stations are wheelchair accessible too.
AirTrain is free within the airport including Lefferts Blvd and Federal Circle, you only pay when you exit at either Howard Beach or Jamaica terminals. There is no bus service in long term parking, wear comfy shoes.
does it cost anything from terminal 4 till Howard beach station?
Hi, I'm travelling in September to NYC with 3 relatives (and a total of 4 large pieces of luggage). Our flight arrives at Terminal 4 and we need to get to Long Island City. Nearby our hotel are the subway stations Queensboro Plaza and Queensbridge (Queens Plaza is a tiny bit farther away, but it's still near). My question is: which is the best way to get there? I understand the AirTrain could help us somehow, but we need guidance in terms of how to get from Terminal 4 to where we need to go (step by step, please! We are a bunch of NYC first timers). Also, how much will this cost vs a taxi fare to the same place? Thank you so much in advance!
Take a taxi, fare is around $45. You can split the fare between the four of you and you won't have to schlep your bags on the subways which would require multiple transfers, Airtrain/subway would cost $7.75 per person.
I need to know how to get from JFK to a train that will take me up to Rhinebeck/Rhinecliff. If you know aprox how long this travel would take that would be helpful also.
Amtrak's Empire train from Penn Station stops at Rhinecliff. Take Airtrain from terminal to Jamaica Station and either E subway or LIRR to Penn Station. See Amtrak for schedules and fares; travel from airport to Penn Station is 45 mintues/1 hour and travel time to Rhinecliff is about 90 minutes.
My daughter (17) is flying alone for the first time, will arrive from Stockholm with Delta to terminal 3. Is it difficult to find the airtrain when changing terminal? Is the way well-signed?
Just follow the signs to Airtrain. Track 2 is the terminal-only loop, track 1 trains go to the Howard Beach or Jamaica terminals.
I am planning on buying a weekly MTA card.
How do I pay for Airlink($5)and MTA A train at Howard St.
Do I buy separate MTA Card for Airlink?
Do I scan both cards?
You cannot use the weekly Metrocard for Airtrain so you would have to purchase a separate pay-per-ride Metrocard to pay the Airtrain fare and use the weekly card for subway fare.
Subways and Airtrain run 24/7.
How do I get from Newark Aiport or Newark Penn Station to JFK Aiport EASILY?
State Shuttle at Ground Transportation to Newark Airport.


Whether you have been injured in a car, motorbike or on public transport, a road traffic accident is a traumatic experience. If you have been injured in an accident which was not your fault, you may be entitled to make a road traffic accident claim.
Our specialist solicitors are experienced in dealing with road accident claims and can guide you through the process with expert advice and support.
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Anatomically preserved conifer-like stems from the upper Carboniferous of England
J. Galtier, Andrew C. Scott, J.H Powell, B.W Glover, C.N Waters
Plant Palaeobiology Research Group
Proceedings of the Royal Society B: Biological sciences
Upper Carboniferous
wood anatomy
Full TextSubmitted manuscript, 1.83 MB
http://links.jstor.org/sici?sici=0962-8452%2819920323%29247%3A1320%3C211%3AAPCSFT%3E2.0.CO%3B2-T
Galtier, J., Scott, A. C., Powell, J. H., Glover, B. W., & Waters, C. N. (1992). Anatomically preserved conifer-like stems from the upper Carboniferous of England. Proceedings of the Royal Society B: Biological sciences, 247(1320), 211-214. http://links.jstor.org/sici?sici=0962-8452%2819920323%29247%3A1320%3C211%3AAPCSFT%3E2.0.CO%3B2-T
Galtier, J. ; Scott, Andrew C. ; Powell, J.H et al. / Anatomically preserved conifer-like stems from the upper Carboniferous of England. In: Proceedings of the Royal Society B: Biological sciences. 1992 ; Vol. 247, No. 1320. pp. 211-214.
@article{59295bd549df445b8446105553d241fe,
title = "Anatomically preserved conifer-like stems from the upper Carboniferous of England",
keywords = "Gymnosperms, conifers, Upper Carboniferous, wood anatomy, xylem",
author = "J. Galtier and Scott, {Andrew C.} and J.H Powell and B.W Glover and C.N Waters",
journal = "Proceedings of the Royal Society B: Biological sciences",
publisher = "The Royal Society",
Galtier, J, Scott, AC, Powell, JH, Glover, BW & Waters, CN 1992, 'Anatomically preserved conifer-like stems from the upper Carboniferous of England', Proceedings of the Royal Society B: Biological sciences, vol. 247, no. 1320, pp. 211-214. <http://links.jstor.org/sici?sici=0962-8452%2819920323%29247%3A1320%3C211%3AAPCSFT%3E2.0.CO%3B2-T>
Anatomically preserved conifer-like stems from the upper Carboniferous of England. / Galtier, J.; Scott, Andrew C.; Powell, J.H et al.
In: Proceedings of the Royal Society B: Biological sciences, Vol. 247, No. 1320, 23.03.1992, p. 211-214.
T1 - Anatomically preserved conifer-like stems from the upper Carboniferous of England
AU - Galtier, J.
AU - Scott, Andrew C.
AU - Powell, J.H
AU - Glover, B.W
AU - Waters, C.N
KW - Gymnosperms
KW - conifers
KW - Upper Carboniferous
KW - wood anatomy
KW - xylem
JO - Proceedings of the Royal Society B: Biological sciences
JF - Proceedings of the Royal Society B: Biological sciences
Galtier J, Scott AC, Powell JH, Glover BW, Waters CN. Anatomically preserved conifer-like stems from the upper Carboniferous of England. Proceedings of the Royal Society B: Biological sciences. 1992 Mar 23;247(1320):211-214.

redpajama_set_name: RedPajamaCommonCrawl


text:
https://www.barrons.com/articles/nearly-half-of-single-women-in-the-u-s-give-to-racial-justice-causes-01646770900
Nearly Half of Single Women in the U.S. Give to Racial Justice Causes
March 8, 2022 3:21 pm ET
Around one in seven U.S. households gave money to racial justice causes in 2020, WPI says.
Nearly half of single women in the U.S.—a larger percentage than single men or married couples—supported or were actively involved in racial justice protests in 2020, according to a gender-based giving study released Tuesday, coinciding with the International Women's Day.
Around 48.2% of single women surveyed supported racial justice causes, such as Black Lives Matter, Say Her Name, and others, compared to 40.9% for single men, and 40.3% for married/partnered couples, according to the report titled Women Give 2022: Racial Justice, Gender and Generosity by the Women's Philanthropy Institute (WPI) at the Lilly Family School of Philanthropy of Indiana University–Purdue University Indianapolis.
Nearly half of single women in the U.


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Home » Biography » Rapper » Don Q-Net Worth, Professional Life, Wife, Age, Songs, Albums
Don Q-Net Worth, Professional Life, Wife, Age, Songs, Albums
Posted on Apr 5, 2021, netadmin
Don Q, an American rapper born Le'Quincy Anderson, came to the limelight after releasing the compilation mixtape Highbridge the Label: The Takeover Vol. 1 in collaboration with rapper A Boogie.
Turned professional in 2016, the New York based-rapper & songwriter has 4 mixtapes & a 6-song EP titled Underrated (in 2018).
What Is Rapper Don Q's Net Worth In 2020?
With only 4 years in the rap industry, he has garnered wide fame & fortune. As of May 2020, 30-year-old rapper Don Q has a net worth of $500,000.
Signed with the record labels Highbridge the Label and Atlantic Records, he collects the majority of earnings as a rapper.
Over the years, he is seen frequently collaborating with rapper A Boogie wit da Hoodie; Don Q featured in A Boogie's debut album The Bigger Artist (2017).
Rapper Don Q has a net worth of $500,000 in 2020
Source: Stereogum
Aside from being a rapper, Q earns a considerable sum of money through YouTube channel- his eponymous channel was created on April 11, 2014.
Meanwhile, in May 2020, his channel Don Q has over 127K subscribers & a total of 52.689 million views. According to Social Blade, it can earn him in the range of $1.2K – $18.6K per year.
READ MORE: Mark Rober-Net Worth, Professional Life, Dating, Age, Wife, Son
Potential Earnings From Instagram
Anderson aka Don Q is an active user of Instagram; his Instagram account (@donqhbtl) has over 512K followers as of May 2020.
Despite the fact that the rapper is yet to have any endorsements, if he does sign a promotional deal via Instagram, it can earn him $1,532- $2,553 per sponsored post.
Also, Don Q is an avid user of Twitter & has over 66K followers.
Career As Rapper: How Did Don Q Come To Fame?
By the age of 16, Le'Quincy aka he started his career in rap, he then went for rap battles in streets & later appeared in several rap battle leagues: Battle On The Beat, Blue Collar Television, and Come Up Groundz.
It was until 2016 when Don Q received wide fame as he appeared in the freestyle series on Hot 97.
That same year, the rapper signed with the record label Highbridge the Label & released compilation Highbridge the Label: The Takeover Vol. 1, with A Boogie on May 28, 2016.
Don Q released his solo debut mixtape Don Season in 2016 & has released further 3 mixtapes
Moreover, in August 2016, he released his debut mixtape Don Season in collaboration with Atlantic Records; it was hosted by DJ Don Cannon.
Thereafter, he went to release further 3 mixtapes:
Corner Stories (2017) featuring Dave East, Jadakiss, and Fabolous
Don Talk (2018) featuring Pusha T and Desiigner
Don Season 2 (2018) featuring G Herbo, Dave East and Lil Durk
In late 2018, the rapper dropped a 6 song extended play (EP) titled Underrated.
Throughout his career journey, Don Q has also collaborated with many artists; he was featured in Young Scooter's song 'Diamond' and in Meek Mill's single 'Lights Out', both in 2016.
Where Does Don Q Live & His Lifestyle?
Currently, he lives in Brooklyn, New York, however, he is yet to open up details on his residence.
Surfing through his social media, the American rapper seems to be enjoying perks of success. He drives a Maybach & often wears a diamond-encrusted chain & ring.
Feud With Tory Lanez
Feuds among celebrities are barely a surprising topic these days & same goes for rapper Don, who fired up social media through word exchange with rapper Tory Lanez in 2019.
It came when Lanez proclaimed himself as the greatest rapper alive during an ongoing battle with Joyner Lucas; Don Q got in & responded to Tory & accused him of stealing lyrics from his Hot 97 freestyle.
It resulted in backfire series in social media & releases of diss tracks. Don Q released "I'm Not Joyner" which Tory responded with another track "Don Queen". Don then retaliated with "This Is Ya King?"
When & Where Was Don Q Born? His Relationship?
Don was born Le'Quincy Anderson on April 28, 1990, in Highbridge, Bronx, New York, New York City. An American by nationality, the rapper hails from a black ethnic background.
Even though, Don Q started writing raps while in 5th grade, he later took rap career seriously in high school at age of 16.
Regarding his relationships, he is low-key. No reports on his girlfriend or dating story ever made highlights & are allegedly single for now.
However, the rapper reportedly has a daughter, though e has kept details under curtains.
Did you know? Due to safety concerns, Don Q was among 5 rappers who were banned from New York City's Rolling Loud festival.
Kendall Schmidt-Net Worth, Professional Life, Wife, Age, Songs, Tattoos
Aidy Bryant-Net Worth, Professional Life, Height, Age, Movies, Husband


Investment opportunity - 40 pad RV/Mobile home park, a 2,500 sf rented tavern with R liquor license and an available owner's residence (Ranch,3BR/2BA, 1,012 SF). Individually metered pad sites are both year round and seasonal rentals. Currently operating at 70+% occupancy. Additional 1.15 AC residual land along Route 534 for future development. Also includes parcels 34-21-A2.20 & 34-21-A2.23. Zoned R2-KidderTownship. On-site utilities.


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« Crash inquiry
Downey Studios – health hazards in our workplace »
UCLA Commencement
June 17th, 2009 Posted by haskellwexler
LOS ANGELES, June 16, 2009 – Cinematographer Haskell Wexler, A.S.C., received The UCLA Medal, the university's highest honor, at the 2009 UCLA School of Theater, Film and Television commencement on June 12.
The UCLA Medal was created in 1979 and is awarded to those who have made truly extraordinary and distinguished contributions to their professions and to our society.
Recipients have included national and international leaders in government, education, science, industry and the arts, as well as men and women who have advanced UCLA's development into one of the world's preeminent universities.
Wexler is renowned for his Oscar wins for Who's Afraid of Virginia Woolf and Bound for Glory. His credits include such notable movies as American Graffiti, In the Heat of the Night, The Thomas Crown Affair, Matewan and Coming Home.
Wexler is recognized not only as an influential filmmaker and storyteller, but also as a leading social commentator. Through such influential films as Who's Afraid of Virginia Woolf?, Bound for Glory and Medium Cool, he put a human face on conflicts between family members, social classes and nations at war.
Born in Chicago, he attended UC Berkeley before leaving to serve in World War II. His career began in Illinois, where after creating a studio with his father, he began to learn film production. After landing his first job as a cinematographer in 1958, he went on to work with such legendary directors as Elia Kazan, Mike Nichols, Norman Jewison and Milos Forman.
For UCLA students, he has generously shared his resources and vast knowledge, entrusting footage from his own work to the Film & Television Archive. He also has lectured to UCLA School of Theater, Film and Television classes and mentored alumni.
Mark Hardin
A million congratulations, Haskell!
…and keep on blogging! We, your fans, always appreciate your posts; the causes you take up are invariably good and important ones.
Take it up, take it down, but…well, you know!


Box Nails are probably the most general purpose type of nail that one can find. While some other nails might be considered a specialty fastener made specifically for one application, these are truly multi-purpose. Box nails have a smaller shank and head size than common nails of the same length. This compact design enables box nails to used in a very wide array of applications.
Applications could include Wood Shingles, Framing, Fencing, Siding, Permanent Wood Foundations, Decking applications, Box and Crate assembly, and whatever else you can think of!
Hot Dip Galvanized Nails meet the minimum requirement for ACQ-treated lumber. However, despite the higher corrosion resistance of hot-dipped galvanized nails, we do not recommended them for ACQ-treated wood. Stainless steel is a more suitable choice for this type of lumber.


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Personality: Crazy, with strong sense of courage.
Timmy was one of the Trainers that strayed off his path of becoming a Pokemon trainer, he deicded he would train his Art skills & Proffesion. He always carries an artbook, pencils and paints & paint.


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The Nature Center and Farm has a new name — same great mission.
Nest Nature School
We deliver quality education—for all ages—immersed in nature.
The Nest Nature School
Outdoor Classroom – Field Trips
Deep Roots – Farm-to-Market Program
Nature Explorers Science Adventures
Farm-to-Market Garden Adventures
Little Explorers Adventures
Cibolo Nature Hikes – Scavenger Hunt
Junior Trailblazers – Nature Backpacks
Cibolo Camps
Internships – Ages 16+
Educator Professional Development
Adult Education Workshops
We provide engaging experiences that enhance our community and the lives of our visitors.
Cibolo Nature Center
Herff Farm
Rentals & Photography
Facility & Event Rentals
We promote the conservation of natural resources by using science to inform decision-makers in the practices and policies that affect the quality of life in our region.
Wildlife Field Research
Cibolo Land and Water Initiative
Resilient Boerne
Citizen Science Resources
Learn about our rich history, our campuses and our vision for transforming lives through the love of nature.
Meet the people who make it all happen at the Cibolo.
Get the latest stories from the Cibolo and beyond.
Get engaged with our Cibolo Community and volunteer with us!
Join us and become part of the Cibolo membership community.
Support us and make an impact in promoting natural resources through education and stewardship.
The Cibolo Nature Center & Farm Has a New Name
From Our Deep Roots to a Bright Future – By Carolyn Chipman Evans, Founder & CEO
In a year when all of us have had a chance to step back and reflect, we here at the Cibolo have been hard at work responding to the community's needs and doing some introspection as a team. We are emerging with a new way to represent ourselves, steeped deeply in our history and aiming for a nature-rich future for Boerne and Kendall County.
When we started our work over thirty years ago with a handful of friends, our goal was to clean up and protect a stretch of the Cibolo Creek, a life source of our community. We were known then as the Cibolo Wilderness Trail. As time went by, we realized that the land and water we protected was really a part of something much larger and greater, and our goals grew. In 1992 we built our first building and changed our name to the Cibolo Nature Center. We started our education programs, our citizen science research, and stewardship of Cibolo lands.
We learned that water really does flow downstream and that to preserve Cibolo Creek, we must connect our efforts to a much larger watershed. Over time, our organization has become a primary steward of the Upper Cibolo Watershed, spanning more than 20 miles of waterways and providing over one million gallons per day into critical aquifer recharge.
In 2007 we purchased the Herff Farm to further protect this fragile watershed. We then changed our name to the Cibolo Nature Center & Farm. For the last thirteen years we have worked to take this old abandoned farm and turn it into a public space that builds community through events, education and research. We also started a Nature Preschool and are nearing completion of the campus on the Herff Farm.
Over recent years, we have come to realize that we are much more than a nature center or a farm, and we want a name to reflect that. Our research has become internationally recognized, our educational programming reaches tens of thousands of children and adults each year, our regional conservation efforts are recognized state-wide, and our civic engagement is making a significant impact on the future landscape of our growing community.
It's time once again for a new name.
We are now the Cibolo Center for Conservation!
Our mission remains the same—to promote the conservation of natural resources through education and stewardship. And all of our work will still take place on our two campuses—the Cibolo Nature Center and Herff Farm. In the spring of this coming year, our new preschool at Herff Farm—The Nest Nature School will open, and we hope to fill it with many little fledglings that will have the extraordinary experience of a deep connection to nature.
With 32 years of incredible community support, we have come a long, long way. Together we can build a future with pristine lands and waters for the wildlife and people that depend on them.
Thanks to you, our community, for your care and commitment. . .for all these years. And here's to a new way forward as the Cibolo Center for Conservation!
140 City Park Rd
nature@cibolo.org
33 Herff Rd
Be the first to get details on our latest events and news.
The Friends of Cibolo Wilderness is a 501(c)3 non-profit organization that exists to promote conservation of natural resources through education and stewardship.
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Since Florida's medical cannabis program was expanded, the number of registered patients has doubled from 16,760 to 31,051.
Since Floridians voted to expand their medical cannabis program last year, state lawmakers have pushed to limit the ways marijuana can be consumed. Despite the controversial attempts to restrict the newly approved medical cannabis expansion, the number of registered patients continues to grow immensely.
During the first three years under Florida's highly restrictive medical cannabis laws, there were 16,760 people registered for treatment. But since the list of qualifying ailments was expanded to 10, the patient list has nearly doubled to 31,051.
However, the Florida Office of Medical Marijuana Use has failed to keep up with the explosive demand, leaving many patients without the state-issued identification needed to purchase pot. The department only has 12 employees, a tall order for an office that handles anywhere from 1,000 to 1,300 phone calls a day. On top of that, there's around 3,000 applications pending at once.
Currently, the system requires approved patients to wait 30 days after applying to receive their medical marijuana card, a major improvement over the state's previous 90-day process. But many feel that the four-week wait period is still too lengthy for patients suffering from debilitating conditions such as cancer or HIV.
As a result, the Department of Health is now looking to outsource the call center and licensing processing to other companies. State lawmakers have called for the department to expand its staff to 55 people, but the task of hiring new employees is a timely one. While the marijuana commission agrees that they must expand or contract out their piling amount of work, the office will continue to slowly trudge through applications until a change is made.
"As the program continues to grow, we agree that it is not sustainable to handle in house long-term, which is why we are outsourcing these functions as directed by law. However, while we work through the procurement process, we continue to do our best to process applications and respond to inquiries in a timely manner," said Mara Gambineri, a Department of Health spokeswoman.
Florida physicians hoping to recommend medical marijuana to patients are also facing frustrating delays. Prior to the bill signed by Gov. Rick Scott in June, doctors were required to take part in an eight-hour training session. Although that has been reduced to a two-hour training, neither the Florida Osteopathic Medical Association nor the Florida Medical Association is offering the course as of yet.
The Florida Office of Medical Marijuana Use is pledging to pick up the pace as the new system is integrated into law, but many patients don't have time to wait aroundfor legal cannabis access. Unless the health department is willing to address these glaring issues, a dark cloud will continue to loom over The Sunshine State's medical cannabis program.


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Q: Campo com Cedilha em Mysql Possuo um campo em minha tabela do banco de dados MySql com o nome 'descrição', com os acentos especiais.
O meu problema é:
Quando faço um INSERT INTO utilizando diretamente o phpMyAdmin, ele insere normalmente a informação na tabela, porém ao usar o mysql na aplicação ele retorna o seguinte erro.

Este é o meu código sql:
INSERT INTO caixa_geral_dc (
descrição,
empresa,
valor_c_d,
conta,
categoria,
d_c,
usuario)
VALUES
('GUARDA PROVISÓRIA DE VALORES',
'$nome_cliente[$i]',
'$v_recebido&[$i]',
'7',
'197',
'c',
'$_SERVER[nomeUsuario]')

Aguardo respostas.
Obrigado

A: Coloque o nome do seu campo entre ` para sinalizar que o mesmo é um campo(isto também serve para nomes restritos e/ou com espaços)
INSERT INTO caixa_geral_dc ( `descrição`, empresa, valor_c_d, conta, categoria, d_c, usuario) VALUES ('GUARDA PROVISÓRIA DE VALORES', '$nome_cliente[$i]', '$v_recebido&[$i]', '7', '197', 'c', '$_SERVER[nomeUsuario]')

A: Quando você tem algum campo com caracteres especiais ou espaços em branco nele, esse campo deve ser declarado dentro de ``
Segue como deveria ficar sua query:
INSERT INTO caixa_geral_dc ( `descrição`, empresa, valor_c_d, conta, categoria, d_c, usuario) VALUES ('GUARDA PROVISÓRIA DE VALORES', '$nome_cliente[$i]', '$v_recebido&[$i]', '7', '197', 'c', '$_SERVER[nomeUsuario]')

A: Galera. Obrigado a todos pela ajuda, mas resolvi meu problema.
Bastava adicionar a linha
mysql_set_charset('utf8');
no arquivo conexao.php para funcionar.
Lembrando que também a adição da crase antes de descrição, resolveu o problema.
Ficou assim:

Obrigado messssmo!
Até mais! :D


Electronics and gadgets become more and more seamlessly woven into the fabric of our lives every day. As the internet of things continues to simplify modern day life, recyclers are kept busy adapting to new material compositions, shrinking product sizes and increasing volumes of e-waste. As a part of a dynamic industry, e-waste recyclers are forced to stay innovative to keep up with this technological evolution.
At the recent International Electronics Recycling Congress (IERC) 2018 event in Salzburg, Austria approximately 480 industry representatives from 42 countries met to discuss the latest recycling technologies, regulations, manufacturing processes and value of raw materials.
Steve Skurnac, chief development officer of Sims Metal Management, participated in a panel discussion that focused on one of the central questions that dominated conversations at this year's conference; "Who will benefit most from the increasing volumes of electrical and electronic scrap worldwide in the future?" Mr. Skurnac's response is summarized below in three main parts.
Smaller format items such as wearables, and changing material compositions, along with increased collection costs are going to drive e-waste recycling to be more local.
Regions without any current recycling infrastructure, will need to develop these markets to implement regulations and collection mechanisms.
The same systems that previously processed larger electronic devices are no longer effective with smaller format items, suggesting the need for manual operations.
Also discussed was the need for innovative recycling technologies, strategies for original equipment manufacturer (OEM) and producers, and the opportunities and risks tied to increasing volumes of electronic waste. See the full press release regarding Steve Skurnac's roundtable discussion – Click here.


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Gajendra Moksham: Story of supreme surrender and how it defies Newton laws of motion- A take on Dr. Vipin Gupta's findings in his book – IS DIVINE ENERGY.
The story of Gajendra Moksham is a narration of surrender from Shrimad Bhagavatam, which contains stories from Hindu mythology that pertain to Lord Vishnu or Lord Shri Hari. The Brief of the story is thus:
In a forest on the mountain Trikoota, there lived an Elephant who was the King of the surrounding Jungle. There was a garden there which belonged to the ocean of Gods, Lord Varuna. It was a very hot and sunny day and Gajendra, the elephant king came to the garden of Varuna with his entire family. Gajendra decided to beat the heat by taking a shower so he got into one of the cool lakes to get himself refreshed. He quenched his thirst by drinking the sweet water. As he was crossing the water, he suddenly felt an excruciating pain in his feet and felt it being dragged downwards with the full might of a force. He realized that a crocodile had caught his feet tight and was dragging Gajendra into the water. The more he tried to free his leg from the crocodile's grip the more the crocodile dig his teeth deeper in Gajendra's leg and pulled him even more downwards. This continued for a long time and Gajendra realized that no one, including his family and peers, was able to help him in this precarious situation. He then called upon Lord Vishnu and beseeched his mercy in beautiful Gajendra Strotram. He became oblivious of the pain and Lord Vishnu, pleased by his supreme surrender free him of the pain by ripping off the head of the crocodile by his Divine Discus- Chakra.
The story has many spiritual connotations but I will be Restricting this story to discuss something very interesting and remarkable that Dr. Vipin Gupta Mentions and explains in his spectacular work Project VIPIN's first book of the series – IS DIVINE ENERGY.
Let's understand this story with the findings of Dr. Gupta.
In 1.6 The luminous is the origin of the self- Dr. Gupta says – "The metaphysical reality of the PARAM human child includes both the "guiding spirit" (Ruah, 20) for manifesting the desired future ecosystem reality as well as the "Luminous" (Rochisha, 13)"
The param human child is here Gajendra and he is the present, the absolute of the story, and forms the present consciousness. Dr. Gupta clarifies that the present is absolute which leads to the conception of the sequence of events that become the known reality in the future. He further clarifies that the present consciousness is the absolute consciousness, known as Paramatma. The person present that forms the present is the param human child. That person behaves like first, the param, i.e., the absolute; second, the human, i.e., angry like a human ready at the present ready to change the world to test one's divinity and therefore leading to a sequence of events in the future; and third, as a child, surrendering to the Guiding spirit. Dr. Gupta clarifies that the "Guiding spirit" (Ruah, 20) has two dimensions: intrinsic and extrinsic. The intrinsic works like the space that manifests over three dimensions of time. Therefore, the intrinsic is worth a fourth and the extrinsic is worth three-fourth. The intrinsic dimension makes the param human child the "God" (Ishvara, 5 = 20/4) by making everyone involved in the future sequence of events dance to his tune. The extrinsic dimension makes everyone "breeding" (Janana, 15) the breed that God divines a part of the child's "consciousness family", known as the "soul family" (Mohini, 15 = 20 * 3/4). That consciousness family forms the child's "vision power" (Vishnu, 15), i.e., the Lord Vishnu, to help the child eventually the known reality he conceived as the absolute. Dr. Gupta further clarifies that the child eventualities the known reality by incarnating as a "Luminous" (Rochisha, 13). Now, what is Luminous?
Dr. Gupta defines it as "The Luminous is the source of the light, guiding each animate "cell" (Hiranyagarbha, 19) to devote its consciousness to materialize the desired future reality of nothing as a desirable manifestation."
Hiraṇyagarbha (Sanskrit: हिरण्यगर्भः; literally means the 'golden womb' or 'golden egg', poetically translated as 'universal germ') is the source of the creation of the universe. Why, because in modern scientific parlance, Hiranyagarbha is simply an animate, alive, and breathing cell with whose womb the universe is present. One cell multiplies to produce a universe of cells through the intermediate daughter cells.
Dr. Gupta says that Luminous is the source of light guiding each animate cell. Each cell is the product of "breeding". Dr. Gupta clarifies that in modern scientific parlance, the fancy name for breeding is "Meiosis" (Param Shiva, 15), the process through which a cell divides and multiplies into six cells, after unifying an octave of cells to transform itself into an animate cell. You may ask that why scientists have not been able to find the nine cells that precede the six cells known to result from the meiosis. Dr. Gupta clarifies that the octave of cells is in the form of the "octave of atoms" (Dik, 100) since an atom is an inanimate cell, when a cell dies it becomes an atom by exchanging its energy from the inanimate to animate form. An octave comprises eight elements. Further, the octave of atoms is immanent within a "neutron" (Matsarya, 19). A neutron is a medium for dividing a unit cell into an octave and letting the unit cell behave like a neutron by servicing its energy to the neutron. That empowers the neutron to become the "nucleus" (Yoni, 1000), the femininity, and incarnate as the golden egg. That's why the cell, the atom, and the neutron all have energy values that through a sequence of events transform 1 into 9, i.e., 19. Dr. Gupta clarifies this Vedic wisdom for us to understand that the universe was and is created by incubating the Hiranyagarbha or the golden egg and the Luminous was and is the master incubator. Dr. Gupta explains that the Luminous is the master incubator because scientifically it is the "mass of energy". It becomes 'self-luminous" (Svarochisha, 12) within the one conceiving the octave to manifest the known reality."
Now in our example here, the Gajendra behaves like a mass of energy that rapidly multiplies its energy by breeding the mass of energy within everyone bred by the energy. Thus, it spontaneously and effortlessly manifests the known reality of the "freedom from the present force" (Moksha, 1600) when faced with the dilemma of life and death. He does so with the power of devotion to the present, thus generating the fire that destroys the present and illuminates the future one desires. To quote Dr. Gupta here, it-
"Polarizes its consciousness into nothing, constituting the imaginary manifestation, the "sentient light force" (Apas, 169) of that consciousness transforms the "nothing" (Adravya, -1) into the imagined "thing" (Vastu, 9)" That is Gajendra becomes oblivious of the pain and sorrow and channelizes his energy into focused Devotion – complete surrender, to activate the "creator factor" (Bhagwan, 4). He becomes the Animate factor himself, activating the divine luminosity within him to conceive Hiranyagarbha as the energy solution. In the story, Gajendra is trying to pull out upwards and the crocodile is pulling him downwards. Dr. Gupta says the Crocodile is present in the past, whose "consciousness" (Chetana, 4) is the "creator factor" (Bhagwan, 4), known as Bhagwan. Gajendra decides to embody the entire presentation so that his consciousness of the challenge eventuated through the past sequence of events becomes the thirteen-unit mass of energy. That mass of energy comprises the four-unit consciousness and the nine=unit imagined thing. Thus, the consciousness of the problem itself becomes the solution for transcending beyond the problem and becoming the present consciousness in the future for solving all problems.
This is the perfect setting to explain the TEN GROUPS OF ILLUSIONARY POINTS constituting ten directions in the manifested space that Dr. Gupta speaks about.
"The first eight groups of points have an arch of 45 degrees and generate an energy field of 45 * 8 = 360 degrees. The ninth group of points covers the distance from the center to the circumference of the Luminous. Within this ninth group, the energy flows from the intrinsic "spiritual center" (Sati-Parvati, 16) towards the Luminous's top direction. The tenth group of points is from the extrinsic "gravitational center" (Jamadagni, 629) of the energy field to the Luminous center. Within this tenth group, the energy flows from the top energy field towards the Luminous's bottom direction"
Dr. Gupta says the gravitational center of the entire story and the sequence of events, past, present, and future, is the Crocodile. Without Crocodile becoming a problem, the solution will not become Luminous. Therefore, the crocodile is the Jamddagani that transforms scientifically possible growth of 6 units for materializing the imagined thing of nine units, by organizing 2 units of time within the one that is present as Gajendra's illusionary production of oneself. Thus, Jamadagni has an energy value of 629. As the gravitational center, the Crocodile is pulling the consciousness of Gajendra downwards towards the past so that the problem becomes insurmountable to solve with the energy Gajendra has. As the absolute, Gajendra is trying to reach out to the Luminous Top direction of his consciousness. Evidently, six-unit of scientifically possible growth is not a sufficient solution for the emerging problem of imminent death through entanglement into the past. It is already known to the crocodile who has moved forward fast to transform those six units into nine units, effortlessly taking advantage of the one unit that Gajendra is conceiving to also move forward.
The "necessary solution" (Vastunara, 7) is for Gajendra to be conscious of the "reality" (Vastavikta, 7) of both the scientifically possible growth and the need for him to consciously channel that growth for multiplying each of the six units within the growth into six additional units as a "channel" (Raasta, 36). Scientifically, the necessary solution is the "ideal point" that compensates for the pull from the gravitational center and lets one enjoy freedom from the present, force, or what is known as Moksha. This reality is an "unknown reality" (Vastavikta, 7), it is unknown to both the Crocodile and Gajendra. It requires Gajendra to be a seven-unit "conscious entity" (Siddha, 7), conscious of the four dimensions of space and three dimensions of time. Therefore, the reality is seven units. When Gajendra supplements the scientifically possible growth with the metaphysically possible reality, he becomes the "Luminous" (Rochisha, 13 = 6 + 7). He is no longer absolute. He is not even aware that he is the conscious entity who transforms the past absolute to be the present absolute, also known as omnipresent, overall space and time dimensions. Thus, he becomes the omnipresent" (Sarvavyapak, 1), the one unit that is always present within everyone in the decentralized future. Paradoxically, Gajendra is not conscious that he has become omnipresent, because he is busy making himself Luminous so that others know his story and become "omnipotent" (Sarvashaktiman, 1600). Now, you should be able to quantify the energy value of omnipotent, because by following the story of how Gajendra became omnipresent from being the present, you are now the present who embodies the known reality of Gajendra. Not only you are present, you have also become omnipotent knowing that the necessary solution to each problem is within you. That necessary solution is for you to polarise all energy units using the consciousness of the four-space dimensions and the three-time dimensions to get out of the situation. When you do so, Dr. Gupta says you become a "DEVOTED PARAM PERPETUATOR" (Ananta, 90000). In other words, you become an "infinity" (Ananta, 90,000), enjoying the life of the "eternity" (Ananta, 90,000). Why, because, you know how to get out of any situation without being stuck in that. You know how to live when the situation brings you near your death.
If you are amazed at how the ancient wisdom of India went much beyond modern science, then don't let your amazement die. Here is more to fuel your confidence that our children have the potential to falsify the limitations that the scientists bind us with their law-like statements in the name of pure physics and become the metaphysicists that Dr. Gupta wishes them to be.
Dr. Gupta explains how we have just witnessed the Non –Confirmation to Newton's law of motion. Let me just take the explanation related to the third law of motion.
Contrary to Newton's third law of motion, the self-luminous entity's reaction is not of equal value and in the opposite direction to that of the Luminous. Gajendra is being pulled downwards with more power than him pulling upwards, and that's why he can't get out of the water. Without the one unit conceived by Gajendra as a conscious entity before it becomes known to the crocodile, the crocodile incarnates as a "self-luminous entity" (Svayam, 12: 13 -1). A self-luminous entity is the primordial human child, the "creature" (Purusha, 12) who pulls the known reality of him becoming the "param human child" (Kesari Nandan, 1600) downward because of the immanent fear about the unknown.
This story though has a lot of spiritual essences attached to it, Dr. Gupta has simplifies it to the play of energies in all ten directions of organizational planning-Horizontal, vertical, seven intrinsic, and one extrinsic. He has clearly shown us that the flow of divine energy defies Newton's laws and we should unlearn the science we have been spoonfed over the past many centuries to learn the true science which lays hidden in the shrouds of our Vedic wisdom, which Dr. Vipin Gupta has painstakingly simplified for us to comprehend.
So next time you talk about the action-reaction thing, think about The Gajendra Moksham and elevate your self-luminosity by recalling Dr. Gupta's 10 groups of illusionary points, around which the divine energy plays its Ananta game till Infinity.
-Ranjula Jain
https://www.amazon.in/Divine-Energy-Vipin-Gupta/dp/108796279X/ref=sr_1_8?dchild=1&keywords=vipin+gupta&qid=1626358948&sr=8-8
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Categories: Blog / Published On: July 25th, 2021 /
SATI-PARVATI – The self-Luminous Grandmother entity
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Svarochisha – the self-luminous "I"(Svayam)
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SATARUPA- The deity with a thousand forms or one's Eight- fold growth in self-awareness. Dr. Gupta's explanation that's bound to get your imaginations soaring with limitless excitements
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Who is a Guru? Is Guru Divine or is it vice-versa?
Leader- the Divine Intervention, from a a follower's perspective


Have you ever wanted to pursue something just for yourself?
Today we have Lindsey Johnson on the show and we talk all about her starting her business, being a mom of 3 and homeschooling. Lindsey shares with us how she grew her business slowly but steadily and that she preferred it that way vs. growing it super fast. We chat about her schedule and what that looks like in a week with homeschooling and running a business and how its key to get the most important tasks done first. One tip that she gave us that really stood out to me is when she said that if you want to start a business then you have to offer a solution to a problem and that is what you have to remember in order to be successful in what you are doing. Hear what she says about this topic and more on the podcast.


The year is coming to its end, but the desire to attend educational and entertaining conferences still remains. We hasten to inform you about 3 biggest conferences dedicated to product management industry.
We truly believe that this article we came across with would not seem belated – it is still relevant and worth visiting the last absolutely attractive European product management conferences.
What to expect: it is a famous and quite large hangout of experienced product management professionals, who are glad to share their thoughts and ideas about innovation in the industry. The conference of this year is dedicated to the importance of newsletters subscribing and which impact it has on the product promotion. JAM is a great possibility to dive into a friendly community of product managers – hurry up to buy the tickets – there are only 50 tickets for this conf!
What to expect: if you prefer a warmer climate and if you are interested in a more technically specified lectures, you will be satisfied with the traditional Productized Conference. Lots of mastermind specialists, many product management workshops and delightful coffee breaks (yes, it means a lot, too!) – there you can spend you time in a proper way and receive valuable insights!
What to expect: it is considered to be the biggest event in the product management world! Indeed, it is held in the remarkable place with many experienced enthusiasts who are open to tell about their professional secrets and make your own knowledge richer! it is necessary not to spin it out with the tickets buying!


ဖုတ်ဖုတ်ဖြပ်ဖြပ် အသံကျယ်ကျယ်လောင်လောင် ၊ a loud and disturbing noise , clattering noise.
တရားမဝင် အဖွဲ့ အစု ၊ an illegal enterprise (such as extortion or fraud or drug peddling or prostitution) carried on for profit . Syns : fraudulent scheme, illegitimate enterprise.
တူရိယာ မပါသော သောတအာရုံ အတွက် ဆူညံ အသံ ၊ the auditory experience of sound that lacks musical quality; sound that is a disagreeable auditory experience .Syns : noise, dissonance.
အားကစား ပစ္စည်း ဘက်ရိုက်တံ ( ကြက်တောင်ရိုက်တံ - တင်းနစ်ဘော ရိုက်တံ ) ၊ a sports implement (usually consisting of a handle and an oval frame with a tightly interlaced network of strings) used to strike a ball (or shuttlecock) in various games .Syn : racquet.
Maung Jotu smashed his racket .


text:
Punkvulture
Bryce Galloway
Deep in irony, a tribute to Punk Rock at the National Museum: Punkulture - Images From A Music Revolution is at Te Papa until the end of May. Let us examine this collision of cultures.
Not long after visiting Punkulture for myself I read a review of the same in Wellington's local entertainment guide, The Package. The writer described what sounded like a fictitious opening scenario used as metaphor for the exhibition's short-comings: It read "What do you get when you cross a room full of suits, people with styrofoam mohawks on their heads... and "Anarchy In The UK" playing softly on a loop in the background?"
Punkulture, Level 4, Te Papa. "Right next to the dead horse."1
On contacting the review's writer (Kerry Lee) I found that this was in fact a faithful account of Punkulture's opening.
Surreal! He had, however, omitted the bit about the pair of costume-hire punks that greeted guests on arrival, escorting them up to the exhibition space, all the while sounding every contrived Punk Rock clich� they could muster, all in bad Cockney. Drama students? Shame on you.
The exhibition is sponsored by Ericsson, the mobile phone company. Ericsson's attempts to hijack any remaining currency attached to Punk as word and phenomenon come as no surprise. They go to show just how little currency Punk has left. Punk has been milked by every artist looking to shorthand notions of "fuck you" integrity, and been stereotyped by middle culture to signpost anything weird (especially in advertising). What remains of Punk is banal cartoon character, all crazy hair and expletives, withering on the time line of post war youth culture and its endless reactionary spasms.
So what do we get for our taxes? Moving through in real time: a videowall of bargain bin album covers. A jukebox playing such gems as the first album by The Police!? Endless lovely photographs in punked-up wooden frames. A conversation with Joe Strummer piped-in over a leopard print couch. Some punk fashion through the windows of a life-like London tube train with hiss 'n' rumble sound effects.
There is also a corner of the exhibition dedicated to Punk Rock in New Zealand. In this same corner an old telly plays out time capsule footage from Punk's heyday. This is at least appropriate in that New Zealand experienced Punk late and via the small screen.
In March '77, current affairs programme Eyewitness had Dylan Taite reporting from London on the burgeoning Punk phenomenon. Dunedin resident Chris Knox shaved a proto-mohawk into his head and formed The Enemy. Punk had arrived in New Zealand.
The world was a big place back then. There was no internet. Copies of the New Musical Express arrived from England after a three-month voyage on some creaking old container ship. This and other elements of the contextual landscape are not outlined for young people born into a world of fibre optics and globalisation. In fact, young punters used to the excesses of Marilyn Manson and Eminem will be wondering what all the fuss was about.
The curators of this show would have done well to give us something less generic. This is as bland and non-specific as it gets. No Punk as microcosm nor, conversely, an examination of Punk's mutations, mentors, descendants.
Te Papa did not commission Punkulture. The exhibition had toured out of England for several years and even been retired before Te Papa requested it be sent here. It's like some English PR company decided to do punk while high on the "Cool Britannia" of their country's own pop cultural renaissance. Otago is the next and last stop on Punkulture's marathon world tour.
Te Papa attempts to bring the glorious dead of our proud histories back to life. With Punkulture, the task is beyondthem. Any survey of such burning moments as Punk, Fluxus or Dada should present the ideas that ignited minds and the context of this blossoming. Old dusty artefacts of transient phenomena at war with their times, in themselves, tell us next to nothing. Here, punk is irrelevant. You'd do better to look for those responding to the now.
So forget Punk. For me it's more alive in the Dogma film makers' lo-fi purist aesthetic, its success and middle-finger to Hollywood's billion dollar movie industry. In Jarvis Cocker's British Music Awards stage invasion, shaking his skinny white arse all over Michael Jackson's "I am Jesus, suffer the little children unto me". Or something as successful as Pitch Black still unsigned to a major label because they can't be fucked with conversations on how to turn a seven minute electro-dub movement into a four-minute single-and-video package. Undermining the language of power. Borrowing Punk styles don't count for shit, whether you're Fred Durst in stadium rock or Tony de Lautour at Hamish McKay. Hell, even Mel C can flip-the-bird and cover Anarchy In The UK.
1. Kerry Lee - The Package.
Bryce Galloway is an artist from Wellington. When asked by his English teacher what R.P.M. stood for, he answered, and he wasn't trying to be funny, "Revelations per minute?" More Protestant than Punk really.


text:
In Music Reviews
Sick Transit Gloria Mundi
Nocturnal Art
Red Harvest are back with yet another album of industrial trash metal, and this is surely their finest hour yet. Growing increasingly more complex, the Norwegian five-piece is also more brutal and uncompromising than ever before, with this album adding both black and grindcore to an already punishing recipe. A conceptual album of sorts, it is still hard to discern a clear narrative on here, and the album is a rather frightening detailing of man in a state of self-inflicted decay and apathy. No less. Plus, we get a fair cover version of good old "Dead Men Don't Rape" to prove that their hearts are in the right place.
A heavy and furious album if ever there was one, Red Harvest dare include more hypnotic and droning arrangements as well this time around, as if they've grown more assure of who they are and less inclined to play by the rules of metaldom. It's a brave move and one echoed in the band's mature writing and complex arrangements. It has the potential of backfiring on them, though: the album is almost too considered for its own good, too planned and controlled. You'll catch yourself wishing for some abandonment and uncontrolled outbursts on here, although Red Harvest may reasonably argue that that'd run contrary to the entire idea behind the album.
As it is, this is ultimately a self-de(con)structive project, with the music embracing the very images of dissolution of self and of organic coherency and independence that the lyrics conjure. And while that doesn't necessarily make for great music, Red Harvest's considered and brutal thinking-man's metal ensures that interest is maintained throughout. A crowded and layered album, it's hard to take this in one sitting. Red Harvest demand your full attention and come out looking all the better for it.
Nocturnal Art Productions: http://www.nocturnalart.com
Stein Haukland
GGFH
Jesse Terry
Natural (Jackson Beach Records). Review by James Mann.
Review by Drew Id
Misty In Roots
Roots Controller (Realworld). Review by Bill Campbell.
Vinnie Moore
Defying Gravity (Shrapnel). Review by George Jegadesh. ,
Mike Watt
Event Review by Brent Dey
Bob Hope Entertaining the Troops: American Entertainers in World
Archival footage and interviews show us the entertainers of the 1940's as they do their part for the war effort.
The Best of Gota (Instinct). Review by Bill Campbell.
Beth Hirsch
There are simply so many albums of this kind of music out there, it gets hard…
Big In Iowa
The band name comes from a quote attributed to the grandfather of one of the …
If Thousands
Lullaby (Silber). Review by Stein Haukland.
The Showdown
Temptation Come My Way (Mono Vs. Stereo). Review by Jen Cray.
Angels & Airwaves
I-Empire (Suretone/Geffen). Review by Jen Cray.


In our 28th year, we realize how blessed we have been to impact so many lives by simply doing what we are passionate about. We attribute our success to the long-term, genuine relationships we forge with our clients, and our focus on helping each client gain clarity, confidence and capability. We have stood with our clients at weddings, baptisms, and funerals; celebrating milestones and walking alongside in times of trouble. What an amazing honor it has been and continues to be.
To hold your interests as paramount.
To listen closely and empathetically, seeking to understand what is most important to you and why.
To be your ally; the first people you will think of when you need help.
To be caring, compassionate and concerned for you and your family.
To earn your referrals and make you glad that you referred your family and friends.
To strive to have the courage to tell you what we think you need to hear and not only what you want to hear.
To shepherd you with discernment, educate you with truth, and coach you toward making solid and informed decisions.
of financial freedom as is offered in and through biblical financial and life principles.
We will bring biblical financial and life principles and influence to all whom God brings our way, being transformation agents in our clients' lives for greater impact and freedom, and bringing a sense of clarity, confidence, and capability.
We will provide servant leadership, creativity, relationship and capability through mutual accountability among ourselves and with our clients. Leadership provides direction. Relationship provides confidence. Creativity provides capability.
We will shepherd clients with wisdom, discernment, care and compassion; being a place of wise counsel.
We will help our clients live from the heart (wellspring of life) and make financial decisions in the context of their whole lives.
We will be a resource to other advisors, locally and nationally, who share similar objectives.


text:
QCC STAFF
Frequently Asked Questions about QCC
CREATING QUEER COMMUNITY
QUEER CONVERSATIONS ON CULTURE AND THE ARTS
Gallery 1 – Archive
VISUAL ARTS EXHIBITIONS
From Self to Selfie 2017
Creative Labor – 2016
Glitter Bomb Exhibition – 2015
Body, body, bodies… 2014
Zeitgeist Exhibition – 2013
REMIX – 2012
QIY: Queer It Yourself – 2011
Chronotopia – 2010
THREADS – 2009
Making Room For Wonder – 2008
Rudy Lemcke – City of the Future (after Tarkovsky's Solaris) – 2007
Tee Corinne – 2007
Hope and Healing – 2006
War – 2005
Spouses for Life – 2004
EG: (r)Evolution of Gender – 2003
The Cockettes – 2002
Lenore Chinn – 2001
Lesbian ConneXion/s – 2001
Jerome Caja 2000
Bernice Bing Retrospective – 1999
FACE Exhibition – 1998
Rik Haber & Cheena Marie Lo
SF LGBT Community Center, 2nd floor 1800 Market St.
6:00pm visual arts opening, 7:30pm performance and video showcase
SICK is a performance, visual and video arts showcase featuring 16 gender variant artists from around the US who are chronically ill. Definitions are inherently constraining which is why many gender variant and chronically ill folks resist identity categories that often hew to normative binaries. SICK artists have created works to explore the intersection of gender and illness and how complicated and interesting existing outside of normative experiences can be.
This FREE event takes place on Thursday, May 9th at the San Francisco LGBT Center starting with the visual arts exhibition at 6:00pm, followed by videos and performances at 7:30pm.
Check out our artist's biographies and work samples at our website sickcollective.org and join us on Facebook at http://on.fb.me/166Dad2 We are proudly co-sponsored by the Queer Cultural Center, El Rio, Fabulosa Fest, Hard French, Michael Malter, Rainbow Grocery: A Worker Owned Cooperative, The Sisters of Perpetual Indulgence, and The Trans Justice Funding Project.
Website: sickcollective.org
Facebook: https://www.facebook.com/events/414078348683492/?ref=ts&fref=ts
FUNDERS AND SPONSORS
Rainbow Grocery: A Worker Owned Corporative
Visual Artists:
Skip Heatwave is a canadian queer trans artist residing in New Orleans. He publishes his own comic called "SO OUTTA HERE" of which there is four issues to date. He is a printmaker art school drop-out. Skip's work is always deeply personal and usually rooted in the juxtaposition of memory and fantasy. This will be Skip's first venture into talking about his world as a type one diabetic and the way it relates with all the parts of his identity in the art medium.
Terry X is a writer and visual artist born and raised in the Bay Area. Their rising is in Scorpio and their moon wishes it was is in the crescent-shaped glint of Beyoncé's eyes. They currently spend a lot of their time reading library books and making waves with local artists before they must bid farewell to the Bay for Los Angeles and the study of cinema later this year. They also enjoy making wearable items that salute queer existence. Other fields of interest include global feminism, magic, decolonization, psychoanalysis, and coconuts.
Emmet Phipps is a queer, transgender printmaker, HIV/AIDS specialist registered nurse, learning herbalist, and soon to be Family Nurse Practitioner providing primary care to transgender communities. They are white/Polish-American, and come from a working class family in the northeast U.S. Emmet got Type 1 diabetes at age nineteen, around the same time they started printmaking. Emmet has lived in Brooklyn, NY their whole adult life. They are a nurse/organizer with Third Space Healing at the Audre Lorde Project in NYC and with the Allied Media Conference in Detroit where they work on new models of healthcare/community care alongside folks from disability and healing justice movements. If you have any questions about Emmet's artwork, you can contact them at eephipps@gmail.com.
Dominic Cinnamon Bradley is a Black gender non-conforming, 'crip and sick' multidisciplinary artist from the Dirty South. Dominic holds a B.A. in Sociology from The Johns Hopkins University and an M.S. in Social Work from Columbia University. During a tenure with the We Got Issues! Leadership Institute, Dominic came to identify centrally as an artist-activist. Dominic has explored acting, spoken word, visual art, performance art, photography, and film with plans to expand into more disciplines. Dominic is a proud member of grassroots organization Black Women's Blueprint and is active in their efforts to eradicate rape and sexual assault. Dominic recently completed EMERGENYC—a program of New York University's Hemispheric Institute of Performance and Politics. Dominic now has a residency with the Roots and River Emerging Artist Mentorship Program, which centers the work of queer artists of color. For more information about Dominic's work, please visit www.dommebomb.com
Creatrix Tiara is an interdisciplinary iconoclast exploring the liminality of being a queer female migrant minority through performance art, writing, music, and whatever form fits the message best. She is currently undertaking an MFA in Creative Inquiry at the California Institute of Integral Studies while also actively participating in community activist art around the Bay Area.http://creatrixtiara.com
Erin Upshaw is a Tennessee based artist.
Charlie Laguna is an Oakland based artist
Performance and Video Artists
Michael Garfinkel is a Canadian-born, multi-media artist, living in Vancouver BC. Exhausted by the world of conceptual art, Michael spent the last several years pursuing studies in counseling psychology, and training in Zen Buddhism. Now re-inspired, he is stepping back into the studio with a particular interest in dance, meditation, healing, and queerness.
Sarah Barnard is a multidisciplinary artist and film maker. Her artwork investigates the fluidity of "the other" within a hetero-normative spectrum and examines the ways in which gender performance, desire and objectification are inter‐related through power structures. While there may be aesthetic differences among her sculptures, photographs and film projects, they are firmly linked to one another by recurring modes of contemplation. Barnard's work has been shown at Gallery 825 in West Hollywood, the Harriet & Charles Luckman Gallery in Los Angeles, the Pete & Susan Barrett Gallery in Santa Monica among others across the US. Most recently Barnard's film I Heart Boys was recognized by Australia's Queer Fruits Film Festival as 2012's winner of Outstanding Experimental Short.
Annie Murphy is an Oregon based artist.
DavEnd is a tender-hearted, genderqueer, accordion wielding songwriter, performing artist and designer based in San Francisco. DavEnd has released two studio albums (How To Hold Your Own Hand, Fruits Commonly Mistaken For Vegetables) and for the past 6 years, has been touring extensively in the U.S., performing at queer teen centers, festivals, colleges, theatres and backyards. Between tours, Ms. End designs costumes, and most recently has been producing a new musical, costume designing and dancing in production numbers for songwriter Kimya Dawson, and appearing in Taylor Mac's epic 5 hour play, The Lily's Revenge. DavEnd's current project, "Fabulous Artistic Guys Get Overtly Traumatized Sometimes: The Musical!", brings together the worlds of music and radical performance art in a theatrical extravaganza, exploring the effects of heterosexism and street harassment on the development of queer identity.
Jonah Aline Daniel is a gender variant, white, jewish, chronically ill, amphibious body worker, energetic herbalist, organizer, candlemaker, anti-zionist, radical, spiritual, intuitive, introvert.I am committed to decolonization, embodiment, consent, radical liberatory Judaism, the ocean, ending capitalism, white supremacy, christian dominance and patriarchy, affordable accessible culturally relevant health and healing, earth and environmental justice, plant communication, growing food and medicine, safety for all bodies, mushrooms, bees, home.I am falling more in love with plants and plant medicine every day, deepening in my respect for the wisdom and power of the body, building herbalism and craniosacral therapy practices, studying somatics and trauma, excavating family history, mapping landscapes of pain and memory, singing, resisting christian hegemony, meditating, remembering dreams, riding my own waves, organizing everything, grieving, reckoning, building home inside my body, surrendering to water, learning how to surf, sweating, shedding skin.
Eva Sweeney is a 30-year-old genderqueer disabled female who works primarily as a freelance writer. Her topics include disabilities and sex, gender, and lesbian culture. She currently lives in L.A. with her two dogs. Performing with Eva are: Willa Mamet who lives in Oakland, where she does bodywork and makes art. She and Eva were baby queers together in high school. As well as, Animal Prufrock who is a transperformative artist & scholar currently living in San Francisco.
Dale Madison became a host on the QVC Network in 1991. Dale was one of the first employees of the company who sought and received domestic partnership benefits for his lover. Dale was also the first host to produce an all-African themed shopping hour in the world of television shopping. His own line of handmade African dolls sold out in five minutes. He became a nationally recognized doll designer and traveled the country promoting African art. When his contract ended in 1994, he returned to Baltimore and opened the first Afro-Centric Gay themed gift store (some say in the country!)
In 1995 Dale received a Maryland State Council Artist Award for his one-man show, FREEda SLAVE: Mask of a Diva. The show was based on his experiences as a drag queen background extra on the film, "To Wong Foo, Thanks For Everything Julie Newmar." The show addressed masculine and feminine discrimination within the gay community. After winning a playwriting award in 1999, Dale took the show to Los Angeles and it won the critic's pick of the week in Backstage West. After working in various television and film projects, Dale enrolled in college at the age of 47. During his college years he never slowed down, writing and publishing two books and producing two short films. DREAMBOY: My Life as a QVC Host & Other Hits won the Best LGBT film of 2008 at the San Diego Black film festival and The Panty Man was nominated as best short in the 2009 Pan African Film festival. Dale graduated in 2010 with a Master's degree in education. His second one-man show debuted the following summer to a sold out audience, MY Life in 3 Easy Payments based on his memoirs. In addition, he became a mentor with LifeWorks, a LGBT enrichment youth program. While facilitating performance art workshops at LGBT youth conferences, Dale was asked to become a facilitator of a Black & Latino men's empowerment program through The LA Gay & Lesbian Center, the largest LGBT organization in the world. Through everything Dale has stayed true to himself living life out and proud inspiring others to do the same.
Rik Haber is a gender queer, trans, chronically ill, artist based in San Francisco. Rik has been performing since he was a tiny one and has always found it to be an outlet for exploring the absurdities of gender and problematic social norms. Rik performed in the National Queer Arts Fest last year and feels thrilled to bring a new piece to this year's festival with a brilliant cast of other queer, ill identified folks.
Qcc2Admin	2017-11-10T20:21:11+00:00
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