text:
Argument: Justin Trudeau Is Running a Milk Racket Justin Trudeau Is Running a Milk Racket...
Justin Trudeau Is Running a Milk Racket
Trump is right: Canada's protectionist food policies rip the world off.
By Jonathan Kay
| June 11, 2018, 6:12 PM
A skier wearing a cow costume arrives in the finish area before the second run of the women's slalom race at the FIS Alpine World Ski Championships in St. Moritz, Switzerland on Feb. 18, 2017. (Dimitar Dilkoff/AFP/Getty Images)
Before we pick apart the recent calumnies heaped upon Canada by the president of the United States and his lieutenants, it is useful to meet a woman who may fairly be described as the perfect anti-Trump: a thoughtful, impeccably rational, fluently bilingual Canadian policy wonk named Martha Hall Findlay.
At the federal Liberal Party's epic 2006 convention, Hall Findlay was the only woman among the eight leadership candidates and came in dead last. In 2013, she tried again, campaigning on important but hopelessly technocratic issues such as building a national energy infrastructure. This time, she ranked a respectable third. But since now-Prime Minister Justin Trudeau won that contest on the first ballot with 79 percent of votes cast, silver and bronze ranked as mere footnotes.
Populists such as U.S. President Donald Trump get elected by telling attractive lies. Wonks such as Hall Findlay become noble failures by repeating inconvenient truths. Imagine a U.S. politician beginning her presidential campaign by telling Iowa voters that the federal ethanol mandate makes no sense, that the Second Amendment wasn't drafted to protect individual gun owners, and that building a border wall is a big waste of money. In Canadian terms, that's basically what Hall Findlay — who now serves as the CEO of a respected think tank — did during her last Liberal leadership bid.
You may be tempted to raise an eyebrow when I tell you that the protectionist racket in milk, cheese, eggs, and poultry has become the third rail of Canadian politics. But it should be noted that many otherwise free-trading nations go weird when it comes to food. Japanese rice tariffs have been as high as 1,000 percent. To protect its meat industry, France has passed a law banning the use of labels such as "soy sausage" or "mushroom burger" on vegetarian products. And in the United States, Big Sugar cynically props up a nakedly protectionist law that guarantees a minimum price that's a quantum leap beyond the amount customers would pay on the global market.
Canada's supply-management system — often known as the dairy cartel — is a combination of three market-rigging mechanisms: centralized price-setting, allocated production quotas, and exorbitant tariffs. It's a complete racket that drives massive profits to a relatively small group of largely corporate farm operations. But the dairy industry operates a slick, well-funded lobby and propaganda operation, as the sugar industry does in the United States, that portrays dairy producers as fresh-scrubbed mom-and-pop proles waking up early to ensure Canadians have food on their table. One also hears ridiculous scaremongering to the effect that any relaxation of the supply management system would compromise food safety — as if Wisconsin and New Zealand were selling Canadians dairy moonshine from radioactive cows.
Hall Findlay is one of the few prominent figures in Canadian public life who has drawn attention to this government-mandated scam. In 2012, she came out with a detailed report cataloguing all the harms that supply management does to the Canadian economy. "There is an entire country full of consumers — taxpayers and voters — who are paying one and a half to three times more for their milk, other dairy products, chicken and eggs than they should be — amounting to more than $200 more a year per average family," she wrote. And as for that Norman Rockwell family farm idyll we see in cartel ads: Between 1971 and 2012, "the number of Canadian dairy farms has dropped by a staggering 91 percent." Op-ed writers swooned over the report, praising Hall Findlay's intellectual honesty. But career politicians stared at their feet — including the country's nominal Conservatives.
All of which brings us, finally, to Trump. For it is sometimes the case in politics that even the most cynical and ignorant politician may, by sheer happenstance, stumble accidentally into wisdom. And though Canadians don't like to admit it — especially in light of Trump's appallingly juvenile attacks on Trudeau following the U.S. president's bizarre performance at the G-7 meetings in Quebec — this is the case with Trump's attacks on Canada's dairy racket. It isn't the usual fake news from Trump when he tweets that "Canada charges the U.S. a 270% tariff on Dairy Products!" He's being only slightly imprecise here: The actual breakdown is 270 percent on milk, 245 percent on cheese, and 298 percent on butter. And, as Hall Findlay has argued, the losers aren't just foreign exporters but also Canadian consumers.
While it's sometimes difficult to know precisely what Trump is thinking or talking about when he rails generally about the United States being "the piggy bank that everybody is robbing," the dairy file is one that he's gone after specifically in the past — including a 2017 attack that included his tweet that "Canada has made business for our dairy farmers in Wisconsin and other border states very difficult. We will not stand for this. Watch!" And there have been reports that some relaxation of Canada's supply-management regime would be included in any revision of NAFTA negotiated by the signatories. Many Canadian small-c conservatives have been urging Canada to swallow its pride, admit that Trump has a point, and perhaps leverage this concession to avoid tariffs on steel, aluminum, and auto parts, where Trump is on much shakier ground.
Unfortunately, with his weekend meltdown, Trump now has made this more or less impossible — because giving in to him in the current climate would grate hard against Canada's wounded pride.
Until now, Trudeau has been dealing with Trump in an admirably cool and detached manner. But the G-7 changed everything — at least, until Trump's next change of mood. As Nathaniel Taplin wrote this week in the Wall Street Journal: "It finally happened: U.S. President Donald Trump picked a fight with the nicest people on earth." And with everyone from French President Emmanuel Macron to Ontario's incoming populist premier Doug Ford (a supposed Trump clone) explicitly backing Trudeau, Canada's prime minister has no reason to back away from his popular (but economically perverse and self-defeating) claim that "we will always defend our supply management system."
History shows that all politicians have a mixture of good and bad ideas. But rare is the public figure whose approach is to toxic, so off-putting, that he manages to poison even the most impeccable public-policy positions merely by dint of advocating them. And while American dairy producers have trouble getting their product into Canada, Trump's poisonous influence wafts freely across borders.
Jonathan Kay is a Toronto-based author and journalist. He is a former managing editor at Canada's National Post newspaper. Twitter: @jonkay
Tags: Argument, Canada, Diplomacy, Trade, Trump


Eula Bingham (born July 9, 1929) is an American scientist who is best known as an Assistant Secretary of Labor for Occupational Safety and Health during the Carter Administration.
Eula Bingham was born in Covington, Kentucky, in 1929. She earned a B.S. in 1951 in Chemistry and Biology from Eastern Kentucky University, Richmond, Kentucky; an M.S. in 1954 in Physiology from the University of Cincinnati, Cincinnati, Ohio; and a Ph.D. in 1958 in Zoology, also from the University of Cincinnati, Cincinnati, Ohio. She began her career at the University of Cincinnati School of Medicine in 1961 as a researcher who did pioneering work on chemical carcinogens. She contributed more than one hundred peer reviewed articles on occupational and environmental respiratory hazards; chemical carcinogenesis and related topics; and occupational and environmental health policy.
She served as a scientific and policy advisor for the National Institute for Occupational Safety and Health from 1972 to 1976, in the Department of Labor as an advisor on coke oven emissions and carcinogens (1973–75), in the National Academy of Sciences' Lead in Paint Commission (1974–75), in the Food and Drug Administration, and in the Environmental Protection Agency (1976–77).
President Jimmy Carter appointed her Director of OSHA, and she served through his administration, between 1977 and 1981. During her administration of OSHA notable regulatory activity included revised occupational lead exposure standard and promulgation of regulations on workers' "right to know" about workplace hazards. She later served as Vice President and University Dean for Graduate Studies and Research at the University of Cincinnati (1982–1990), and as a distinguished professor of environmental health at the University of Cincinnati.
1999 - Mary O. Amdur Award, New York University.
1998 - Henry Smythe, Jr., Toxicologist Award, American Academy of Industrial Hygiene.
1995 - American Industrial Hygiene Association's Hamilton Award.
1994 - William Steiger Award, American Conference of Governmental Industrial Hygienists.
1989 - Member, Institute of Medicine, National Academy of Sciences.
1989 - Jerry F. Stara Award, United States Environmental Protection Agency, Cincinnati, OH.
1984 - First Recipient of the William Lloyd Award for Occupational Safety, U.S. Steel Workers Union, Pittsburgh, PA.
1984 - Alice Hamilton Award, American Public Health Association.
1981 - Phil Hart Award, Urban Environment Conference, Washington, DC.
1981 - Doctor of Law (Honorary), College of Mount St. Joseph, Cincinnati, OH.
1980 - Rockefeller Foundation Public Service Award, Washington, D.C.
1980 - Homer N. Calver Award, American Public Health Association, Detroit, MI.
1979 - Doctor of Sciences (Honorary), Eastern Kentucky University, Richmond, KY.
^ a b "Department of Labor Nomination of Eula Bingham To Be an Assistant Secretary". The American Presidency Project. March 11, 1977.
^ a b "Eula Bingham, PhD—Bridging Academia and Government". Journal of Epidemiology and Health. 2004.


Eight months after a meteorite exploded over central Russia, divers have hauled a large chunk of space rock out of a lake, giving people a look at the extraterrestrial object that caused damage throughout the region. On Feb. 15, a 17-m-wide, 10,000-ton meteorite exploded over central Russia. When the rock hit the atmosphere, it caused a bright flash, and some residents said their first thought was that they had seen the start of a nuclear war. Thousands of small fragments fell throughout the region of Chelyabinsk, breaking windows and injuring about 1,500 people.
One of the largest pieces of the meteor fell into Lake Chebarkul, tearing a massive hole in the ice. On Oct. 16, divers finally hauled the half-ton piece of space rock from 20 m of water. Once outside the lake, the chunk broke into three large pieces when it was lifted off the ground with rope, making it harder to determine the precise weight, but an unnamed scientist told the website lifenews.ru that the meteorite weighed 570 kg. "And then the scale broke," he said. "We think the whole thing weighs more than 600 kg." Sergey Zamozdra, an associate professor at Chelyabinsk State University, told the Interfax news agency that the chunk is probably one of the 10 biggest meteorite fragments ever recovered.
The Chelyabinsk meteor wasn't Russia's first brush with crashing objects from space. Scientists at the Imperial College of London estimate that meteorites the size of the one in Chelyabinsk hit the earth's atmosphere about once every 50 years, and Russia was the site of one of the best recorded and most destructive meteor strikes in modern history. In 1908, an asteroid or comet hit the atmosphere and exploded near the Tunguska River in central Russia. In what became known as the "Tunguska Event," the explosion, believed to be 1,000 times more powerful than the atomic bomb dropped on Hiroshima, knocked down 80 million trees over more than 5,180 sq km. Scientists estimate that the blast would have measured 5.0 on the Richter scale.
In 1972, a meteoroid entered earth's atmosphere over Utah in the U.S., traveled north and left the atmosphere over Alberta, Canada. Thousands of people witnessed the fireball, which, like Chelyabinsk, was captured on film. The Great Daylight Fireball didn't cause any harm, unlike the Chelyabinsk meteor, which damaged more than 7,000 buildings and captivated observers around the world. Clips of the meteor quickly racked up millions of hits on YouTube; one of the videos has more than 38 million views.
Scientists have repeatedly said it's a matter of when, not if, the earth is struck again by a large meteor or asteroid. Now that they have seen what caused the destructive fireball last winter, people in central Russia are probably hoping if it happens again, it will happen later, rather than sooner.


text:
Чивилук или вешалица је део намештаја који служи за привремено одлагање капута и јакни. Такође се може користити за одлагање шешира и капа, као и кишобрана. Може бити направљен од дрвета и метала, као и од бројних других материјала.

Види још
 Намештај

Намештај

redpajama_set_name: RedPajamaWikipedia


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The Membrane QmoABC Complex Interacts Directly with the Dissimilatory Adenosine 5'-Phosphosulfate Reductase in Sulfate Reducing Bacteria.
Ines Antunes Pereira
Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
The adenosine 5'-phosphosulfate reductase (AprAB) is the enzyme responsible for the reduction of adenosine 5'-phosphosulfate (APS) to sulfite in the biological process of dissimilatory sulfate reduction, which is carried out by a ubiquitous group of sulfate reducing prokaryotes. The electron donor for AprAB has not been clearly identified, but was proposed to be the QmoABC membrane complex, since an aprBA-qmoABC gene cluster is found in many sulfate reducing and sulfur-oxidizing bacteria. The QmoABC complex is essential for sulfate reduction, but electron transfer between QmoABC and AprAB has not been reported. In this work we provide the first direct evidence that QmoABC and AprAB interact in Desulfovibrio spp., using co-immunoprecipitation, cross-linking Far-Western blot, tag-affinity purification, and surface plasmon resonance studies. This showed that the QmoABC-AprAB complex has a strong steady-state affinity (K(D) = 90 ± 3 nM), but has a transient character due to a fast dissociation rate. Far-Western blot identified QmoA as the Qmo subunit most involved in the interaction. Nevertheless, electron transfer from menaquinol analogs to APS through anaerobically purified QmoABC and AprAB could not be detected. We propose that this reaction requires the involvement of a third partner to allow electron flow driven by a reverse electron bifurcation process, i.e., electron confurcation. This process is deemed essential to allow coupling of APS reduction to chemiosmotic energy conservation.
Frontiers in Microbiology
https://doi.org/10.3389/fmicb.2012.00137
10.3389/fmicb.2012.00137
Pereira, I. A. (2012). The Membrane QmoABC Complex Interacts Directly with the Dissimilatory Adenosine 5'-Phosphosulfate Reductase in Sulfate Reducing Bacteria. Frontiers in Microbiology, 3(NA), 137. https://doi.org/10.3389/fmicb.2012.00137
Pereira, Ines Antunes. / The Membrane QmoABC Complex Interacts Directly with the Dissimilatory Adenosine 5'-Phosphosulfate Reductase in Sulfate Reducing Bacteria. In: Frontiers in Microbiology. 2012 ; Vol. 3, No. NA. pp. 137.
@article{b8068ab98f064c1e96ee1bbdf075829f,
title = "The Membrane QmoABC Complex Interacts Directly with the Dissimilatory Adenosine 5'-Phosphosulfate Reductase in Sulfate Reducing Bacteria.",
abstract = "The adenosine 5'-phosphosulfate reductase (AprAB) is the enzyme responsible for the reduction of adenosine 5'-phosphosulfate (APS) to sulfite in the biological process of dissimilatory sulfate reduction, which is carried out by a ubiquitous group of sulfate reducing prokaryotes. The electron donor for AprAB has not been clearly identified, but was proposed to be the QmoABC membrane complex, since an aprBA-qmoABC gene cluster is found in many sulfate reducing and sulfur-oxidizing bacteria. The QmoABC complex is essential for sulfate reduction, but electron transfer between QmoABC and AprAB has not been reported. In this work we provide the first direct evidence that QmoABC and AprAB interact in Desulfovibrio spp., using co-immunoprecipitation, cross-linking Far-Western blot, tag-affinity purification, and surface plasmon resonance studies. This showed that the QmoABC-AprAB complex has a strong steady-state affinity (K(D) = 90 ± 3 nM), but has a transient character due to a fast dissociation rate. Far-Western blot identified QmoA as the Qmo subunit most involved in the interaction. Nevertheless, electron transfer from menaquinol analogs to APS through anaerobically purified QmoABC and AprAB could not be detected. We propose that this reaction requires the involvement of a third partner to allow electron flow driven by a reverse electron bifurcation process, i.e., electron confurcation. This process is deemed essential to allow coupling of APS reduction to chemiosmotic energy conservation.",
author = "Pereira, {Ines Antunes}",
doi = "10.3389/fmicb.2012.00137",
journal = "Frontiers in Microbiology",
number = "NA",
Pereira, IA 2012, 'The Membrane QmoABC Complex Interacts Directly with the Dissimilatory Adenosine 5'-Phosphosulfate Reductase in Sulfate Reducing Bacteria.', Frontiers in Microbiology, vol. 3, no. NA, pp. 137. https://doi.org/10.3389/fmicb.2012.00137
The Membrane QmoABC Complex Interacts Directly with the Dissimilatory Adenosine 5'-Phosphosulfate Reductase in Sulfate Reducing Bacteria. / Pereira, Ines Antunes.
In: Frontiers in Microbiology, Vol. 3, No. NA, 01.01.2012, p. 137.
T1 - The Membrane QmoABC Complex Interacts Directly with the Dissimilatory Adenosine 5'-Phosphosulfate Reductase in Sulfate Reducing Bacteria.
AU - Pereira, Ines Antunes
N2 - The adenosine 5'-phosphosulfate reductase (AprAB) is the enzyme responsible for the reduction of adenosine 5'-phosphosulfate (APS) to sulfite in the biological process of dissimilatory sulfate reduction, which is carried out by a ubiquitous group of sulfate reducing prokaryotes. The electron donor for AprAB has not been clearly identified, but was proposed to be the QmoABC membrane complex, since an aprBA-qmoABC gene cluster is found in many sulfate reducing and sulfur-oxidizing bacteria. The QmoABC complex is essential for sulfate reduction, but electron transfer between QmoABC and AprAB has not been reported. In this work we provide the first direct evidence that QmoABC and AprAB interact in Desulfovibrio spp., using co-immunoprecipitation, cross-linking Far-Western blot, tag-affinity purification, and surface plasmon resonance studies. This showed that the QmoABC-AprAB complex has a strong steady-state affinity (K(D) = 90 ± 3 nM), but has a transient character due to a fast dissociation rate. Far-Western blot identified QmoA as the Qmo subunit most involved in the interaction. Nevertheless, electron transfer from menaquinol analogs to APS through anaerobically purified QmoABC and AprAB could not be detected. We propose that this reaction requires the involvement of a third partner to allow electron flow driven by a reverse electron bifurcation process, i.e., electron confurcation. This process is deemed essential to allow coupling of APS reduction to chemiosmotic energy conservation.
AB - The adenosine 5'-phosphosulfate reductase (AprAB) is the enzyme responsible for the reduction of adenosine 5'-phosphosulfate (APS) to sulfite in the biological process of dissimilatory sulfate reduction, which is carried out by a ubiquitous group of sulfate reducing prokaryotes. The electron donor for AprAB has not been clearly identified, but was proposed to be the QmoABC membrane complex, since an aprBA-qmoABC gene cluster is found in many sulfate reducing and sulfur-oxidizing bacteria. The QmoABC complex is essential for sulfate reduction, but electron transfer between QmoABC and AprAB has not been reported. In this work we provide the first direct evidence that QmoABC and AprAB interact in Desulfovibrio spp., using co-immunoprecipitation, cross-linking Far-Western blot, tag-affinity purification, and surface plasmon resonance studies. This showed that the QmoABC-AprAB complex has a strong steady-state affinity (K(D) = 90 ± 3 nM), but has a transient character due to a fast dissociation rate. Far-Western blot identified QmoA as the Qmo subunit most involved in the interaction. Nevertheless, electron transfer from menaquinol analogs to APS through anaerobically purified QmoABC and AprAB could not be detected. We propose that this reaction requires the involvement of a third partner to allow electron flow driven by a reverse electron bifurcation process, i.e., electron confurcation. This process is deemed essential to allow coupling of APS reduction to chemiosmotic energy conservation.
U2 - 10.3389/fmicb.2012.00137
DO - 10.3389/fmicb.2012.00137
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
IS - NA
Pereira IA. The Membrane QmoABC Complex Interacts Directly with the Dissimilatory Adenosine 5'-Phosphosulfate Reductase in Sulfate Reducing Bacteria. Frontiers in Microbiology. 2012 Jan 1;3(NA):137. https://doi.org/10.3389/fmicb.2012.00137


To take the success of the solar-powered flight around the world further, the Solar Impulse Foundation, led by Bertrand Piccard, is selecting 1000 solutions that protect the environment in a profitable way.
In October 2018, OpenAirlines has been labelled as a "Solar Impulse Efficient Solution".
Solutions that meet these criteria were attributed the Solar Impulse Efficient Solutions Label.
In 2019, Bertrand Piccard will actively communicate about Efficient Solutions to policy and economic decision-makers. The objective is to bring the fact that today, there exist ways to solve environmental issues that make sense financially and ecologically.
" We need to embrace clean technologies and efficient solutions, because they are much more than 'ecological', they are 'logical' . They create jobs and generate profit, while also reducing CO2 emissions and preserving natural resources. Even if climate change didn't exist, they would make sense. Clean growth is much better than the dirty status quo we have today."


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Macro BOOST_UNITS_STATIC_CONSTANT

BOOST_UNITS_STATIC_CONSTANT

Synopsis

// In header: <boost/units/static_constant.hpp>

BOOST_UNITS_STATIC_CONSTANT(name, type)

Description

A convenience macro that allows definition of static constants in headers in an ODR-safe way.

Copyright © 2003-2008 Matthias Christian Schabel
Copyright © 2007-2010 Steven
      Watanabe

        Distributed under the Boost Software License, Version 1.0. (See accompanying
        file LICENSE_1_0.txt or copy at http://www.boost.org/LICENSE_1_0.txt)

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text:
The TPK algorithm is a simple program introduced by Donald Knuth and Luis Trabb Pardo to illustrate the evolution of computer programming languages. In their 1977 work "The Early Development of Programming Languages", Trabb Pardo and Knuth introduced a small program that involved arrays, indexing, mathematical functions, subroutines, I/O, conditionals and iteration. They then wrote implementations of the algorithm in several early programming languages to show how such concepts were expressed.

To explain the name "TPK", the authors referred to Grimm's law (which concerns the consonants 't', 'p', and 'k'), the sounds in the word "typical", and their own initials (Trabb Pardo and Knuth). In a talk based on the paper, Knuth said:

The algorithm
Knuth describes it as follows:

In pseudocode:

 ask for 11 numbers to be read into a sequence S
 reverse sequence S
 for each item in sequence S
     call a function to do an operation
     if result overflows
         alert user
     else
         print result

The algorithm reads eleven numbers from an input device, stores them in an array, and then processes them in reverse order, applying a user-defined function to each value and reporting either the value of the function or a message to the effect that the value has exceeded some threshold.

Implementations

Implementations in the original paper
In the original paper, which covered "roughly the first decade" of the development of high-level programming languages (from 1945 up to 1957), they gave the following example implementation "in a dialect of ALGOL 60", noting that ALGOL 60 was a later development than the languages actually discussed in the paper:

TPK: begin integer i; real y; real array a[0:10];
   real procedure f(t); real t; value t;
      f := sqrt(abs(t)) + 5 × t ↑ 3;
   for i := 0 step 1 until 10 do read(a[i]);
   for i := 10 step -1 until 0 do
   begin y := f(a[i]);
      if y > 400 then write(i, 'TOO LARGE')
                 else write(i, y);
   end
end TPK.

As many of the early high-level languages could not handle the TPK algorithm exactly, they allow the following modifications:

 If the language supports only integer variables, then assume that all inputs and outputs are integer-valued, and that sqrt(x) means the largest integer not exceeding .

 If the language does not support alphabetic output, then instead of the string 'TOO LARGE', output the number 999.

 If the language does not allow any input and output, then assume that the 11 input values  have been supplied by an external process somehow, and the task is to compute the 22 output values  (with 999 replacing too-large values of ).

 If the language does not allow programmers to define their own functions, then replace f(a[i]) with an expression equivalent to .

With these modifications when necessary, the authors implement this algorithm in Konrad Zuse's Plankalkül, in Goldstine and von Neumann's flow diagrams, in Haskell Curry's proposed notation, in Short Code of John Mauchly and others, in the Intermediate Program Language of Arthur Burks, in the notation of Heinz Rutishauser, in the language and compiler by Corrado Böhm in 1951–52, in Autocode of Alick Glennie, in the A-2 system of Grace Hopper, in the Laning and Zierler system, in the earliest proposed Fortran (1954) of John Backus, in the Autocode for Mark 1 by Tony Brooker, in ПП-2 of Andrey Ershov, in BACAIC of Mandalay Grems and R. E. Porter, in Kompiler 2 of A. Kenton Elsworth and others, in ADES of E. K. Blum, the Internal Translator of Alan Perlis, in Fortran of John Backus, in ARITH-MATIC and MATH-MATIC from Grace Hopper's lab, in the system of Bauer and Samelson, and (in addenda in 2003 and 2009) PACT I and TRANSCODE. They then describe what kind of arithmetic was available, and provide a subjective rating of these languages on parameters of "implementation", "readability", "control structures", "data structures", "machine independence" and "impact", besides mentioning what each was the first to do.

Implementations in more recent languages

C implementation
This shows a C implementation equivalent to the above ALGOL 60.

#include <math.h>
#include <stdio.h>

double f(double t)
{
    return sqrt(fabs(t)) + 5 * pow(t, 3);
}

int main(void)
{
    double a[11] = {0}, y;
    for (int i = 0; i < 11; i++)
        scanf("%lf", &a[i]);

    for (int i = 10; i >= 0; i--) {
        y = f(a[i]);
        if (y > 400)
            printf("%d TOO LARGE\n", i);
        else
            printf("%d %.16g\n", i, y);
    }

    return 0;

}

Python implementation
This shows a Python implementation.

from math import sqrt

def f(t):
    return sqrt(abs(t)) + 5 * t ** 3

a = [float(input()) for _ in range(11)]
for i, t in reversed(list(enumerate(a))):
    y = f(t)
    if y > 400:
        print(i, "TOO LARGE")
    else:
        print(i, y)

Rust implementation
This shows a Rust implementation.

use std::{io, iter::zip};

fn f(t: f64) -> f64 {
    t.abs().sqrt() + 5.0 * t.powi(3)
}

fn main() {
    let mut a = [0f64; 11];
    for (t, input) in zip(&mut a, io::stdin().lines()) {
        *t = input.unwrap().parse().unwrap();
    }

    a.iter().enumerate().rev().for_each(|(i, &t)| match f(t) {
        y if y > 400.0 => println!("{i} TOO LARGE"),
        y => println!("{i} {y}"),
    });
}

References

External links
 Implementations in many languages at Rosetta Code
 Implementations in several languages

1977 in computing
Donald Knuth
Articles with example ALGOL 60 code
Test items in computer languages
Computer programming folklore
Articles with example Python (programming language) code


Kids' Guitar Lessons at Maryville Rock Academy provide a solid foundation of skills and understanding of guitar, so that your children have FUN and feel CONFIDENT when they practice and play. Our Kids Guitar Programs teach how to play guitar correctly so that kids can master the basics and move on to more creative pursuits such as songwriting, jamming, or playing and singing at the same time. At Maryville Rock Academy, it is our mission to develop even our youngest students into creative artists and real musicians.
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A bevy of Navy, Army, Air Force, Police and Civil Defence officers was deployed to beef up security at the Osubi Airport for the arrival of Mrs. Patience Jonathan, and SaharaReporters reliably learned that Otu was at the airport to receive some business partners traveling in from Canada when he was seized upon by the officials.
Larry Otu after he was brutally assaulted by airforcemen attached to mrs. Jonathan Sahara Reporters Media Businessman Larry Otu, the Chief Executive Officer of Lym Consult Nigeria Limited, yesterday got the beating of his life when some overzealous Air Force personnel providing security for the First Lady, Mrs. Patience Jonathan, during her campaign visit to Delta State descended on him.
Eyewitnesses told our reporter that the Air Force personnel, from the 61 NAF Detachment under the command of Air Commodore A. D. Dudusola, were brutal in their duty as they harassed and assaulted several persons, whom they prevented from entering the airport.
They said Otu was mercilessly beaten up by the Air Force personnel. Not only did he receive an enormous wound in the process, Out said the sum of N200,000 was also stolen from him.
Speaking to reporters at the airport shortly after his ordeal, Mr. Otu lamented the assault and brutality meted on him.
He said he was questioned as to whether he knew the President's wife was coming in that day.
He said he complied and took his car back to the main road and was walking back [to the airport] when a team of the Air Force men, numbering about eight, manhandled him.
He called on all relevant authorities to ensure justice by bringing his assailants to book, saying he knew the man who started it all and the one who took the money from his pocket.
Contacted over the incident, Air Commodore, Dudusola defended his men by alleging that Mr. Otu was rude to the officers.
Mrs. Jonathan was originally billed to host her campaign for the re-election of her husband at Oleh, headquarters of Isoko South local government area before the venue of the event was diverted overnight to Orerokpe in Okpe local government area.


Antony Beevor is back with a major new history of Arnhem : the plan to end the war by capturing the bridges leading to the Lower Rhine and beyond. Codenamed Operation Market Garden and famously portrayed in the film A Bridge Too Far (starring Anthony Hopkins, Dirk Bogarde et al) the plan was a bold concept. But could it ever have worked? In this unmissable talk Antony Beevor, drawing on important new sources will reconstruct the terrible reality of the fighting, described by General Student as 'The Last German Victory'. Read more.
Antony Beevor is back with a major new history of Arnhem : the plan to end the war by capturing the bridges leading to the Lower Rhine and beyond. Codenamed Operation Market Garden and famously portrayed in the film A Bridge Too Far (starring Anthony Hopkins, Dirk Bogarde et al) the plan was a bold concept. But could it ever have worked? In this unmissable talk Antony Beevor, drawing on important new sources will reconstruct the terrible reality of the fighting, described by General Student as 'The Last German Victory'.
Antony Beevor is the author of Crete: The Battle and the Resistance (Runciman Prize), Stalingrad (Samuel Johnson Prize, Wolfson Prize for History and Hawthornden Prize), Berlin: The Downfall, The Battle for Spain (Premio La Vanguardia), D-Day: The Battle for Normandy (Prix Henry Malherbe and the RUSI Westminster Medal), The Second World War, and Ardennes 1944 (shortlist Prix Médicis). The Number One bestselling historian in Britain, Beevor's books have appeared in thirty-two languages and have sold just over seven million copies. A former chairman of the Society of Authors, he has received a number of honorary doctorates. He is also a visiting professor at the University of Kent and an Honorary Fellow of King's College, London. He was knighted in 2017.


text:
Mrs dalloway passage anaylis
The effects of media on the lives of people in 1970s america
Ocean speech
Mass surveillance essay
Changing culture, changing habits The way that we interact on the internet is undoubtedly changing as a result of our knowledge of mass surveillance. The harms of surveillance to privacy, expression and association President Obama has welcomed a debate about modern surveillance, but talk of safeguards and reform in the US has led to little or no discernible change for global Internet users.
The opposition to surveillance, however, is not borne only out of a desire for privacy. And all the telephone metadata the NSA Mass surveillance essay led to just one success: Those already-expansive policy goals Mass surveillance essay govern the use of data, not its collection in the first place.
As a result of his political views, Einstein was subjected to telephone tappingand his mail was searched by the U. The novel is set in a province of Oceania in a world of ceaseless war, a pervasive surveillance, and public manipulation through false information.
Not only will the NSA and its allies at the office of the director of national intelligence spend the next several weeks in part advising Obama on what a post-government, metadata custodian ought to look like, the agency will be a major player in shaping the legislation that will bring such a custodian into existence, owing to its advocates in the Senate and House intelligence committees.
For example, they are able to tap in on your phone calls without you knowing. The wartime agency monitored "communications by mail, cable, radio, or other means of transmission passing between the United States and any foreign country".
Most critically, the new measures do not prevent large-scale gathering of data and communications of individuals not linked to any wrongdoing, leaving the vast databanks of intercepted information growing larger for future administrations to exploit.
The latter were defined by their actions real or fabricated by the prosecutionbut also—and this is a key difference—by their a priori membership in a given category: This is more than mean differences found in the Google search terms study before and after June A suggest of putting up surveillance cameras throughtout a school school to preven violence sounds like a good idea right?
Some of the greatest historical figures of the 20th century, including several U. Its Unconstitutional to be watching into people's lives. In earlybefore the Snowden revelations, encrypted traffic accounted for 2. It was even conceivable that they watched everybody all the time.
More specifically, there is no scientific rationale for believing that adding irrelevant data about innocent people makes it easier to find a terrorist attack, and lots of evidence that it does not.
If this government ever became a tyrant, if a dictator ever took charge in this country, the technological capacity that the intelligence community has given the government could enable it to impose total tyranny, and there would be no way to fight back because the most careful effort to combine together in resistance to the government, no matter how privately it was done, is within the reach of the government to know.
In addition, media reports suggest the GCHQ is developing ways to defeat encryption, especially for Internet traffic that it intercepts. The cost was enormous, and ended up frustrating the FBI agents who were obligated to investigate all the tips. With unfettered access to mobile networks, security agencies regularly intercept calls and access phone records, which are then played during abusive interrogations, without any process or oversight.
The NSA gathers a ton of data and sifts through it, ensuring as many people as possible are caught in its nets, even if most of them are released after an algorithmic examination.Mass surveillance.
Mass surveillance is the pervasive surveillance of an entire population, or a substantial fraction thereof. mass surveillance" (Wang).
This furthermore proves that the expansion of sophisticated technological systems like the cameras they are installing aer very costly and are spending. This combination of freedom and democracy-undermining government tactics — state media control, mass surveillance, and the coordinated state-cooperate crackdowns that enforce them is the biggest threat to Enlightenment values today.
And it keeps people from organizing effectively to tackle the biggest security threats of our time. A Study of Interactive Technology and Surveillance is a comprehensive essay written by Lee Humphrys looking into the effects of using social networking sites.
Humphreys takes on the task of looking into many different issues over the course of this one year study. Mass surveillance is an invasion of common man's privacy.
Recent. NSA surveillance is a huge expense on the economy and on the safety of citizens without security benefits making the program worth it, considering its loopholes and its inability to halt terrorism.
Others, including advocates of civil liberties, attack the spying for it could allow secret intelligence to trace the private lives of American. The Aadhaar Bill opens the door to mass surveillance.
This danger needs to be seen in the light of recent attacks on the right to dissent.
No other country, and certainly no democratic country.
Antithesis in a complex sentence
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VERIFY: Are kids using marijuana more now that it's legal in 10 states?
We examine kids who use marijuana in states where recreational pot is already legal.
Are kids using marijuana more now that it's legal in 10 states?
This claim is too broad. In Colorado, data shows fewer high schoolers using altogether. In Washington, fewer students are trying marijuana, but more are using it regularly since the drug was legalized.
To examine youth marijuana use rates we focused on data from two states that were first to legalize recreational marijuana, Colorado and Washington, that both ended prohibition in 2012.
In Colorado the state health department's Healthy Kids Colorado survey includes data from 53,000 school-aged kids.
Excerpt from the Healthy Kids Colorado survey.
But everyone else appears to be using more as use rates for every single age group over 18 went up.
But if we swing over to Washington state there's a different story.
Its Healthy Youth Survey includes data from more than 200,000 students.
While it shows fewer high schoolers experimenting, and fewer high schoolers using occasionally, it says more kids are using cannabis regularly.
The most recent report shows from 2014 to 2016 that 5 percent more 8th graders, 3 percent more 10th graders, and 4 percent more 12th graders said they used marijuana regularly. These are the highest figures recorded since 2002.
Washington state's Healthy Youth Survey says more kids are using cannabis regularly.
However the perceived harm of marijuana is markedly down in Washington.
In 2000, 59 percent of seniors in high school said they perceived marijuana to do great harm to the body with regular use.
In 2016 just 24 percent of seniors said the same thing.
To submit your own question to get VERIFIED, fill out the form below.
On a mobile device click here.


So in between seeing the amazing sites of Paris, you must wine and dine yourself. French cuisine is absolutely one of my favorites. High quality ingredients, magical flavors and extremely reasonably priced wines make your mouth water on a daily basis here. Although there are many places in Paris where you get beautifully plated food that looks like it belongs in an art gallery as opposed to your plate and the prices make your wallet ache a little, there are plenty of places with regional dishes with a more rustic style. These small restaurants and bistros are my real favorites. Food is affordable, but tastes great!
One thing I want to mention about eating in France is that the word entree is not used the same way it is used in the United States. Entree signifies a first course or appetizer in French, whereas in American English, we often use it to signify the main course. So just remember that when you are looking at the entree section of the menu.
Another interesting things you will quickly discover that the best part of Europe is that wine is cheaper than water. We had this bottle for about $20 US, so it is definitely fun to order the delicious wines of France.
I love the handwritten menus at many of the bistros and cafes featuring the chefs daily specials. There are often some great things on there, so always ask the server to help you translate it for you, they were always most happy to do so when I asked.
We had the best French Onion Soup ever while we were in Paris, the broth was really incredible rich. It was at Le Bistro du Perigord (I'll include the address at the end of this post. The restaurant is a small family run restaurant and offers an incredible 3 course menu for 36 euros!).
Don't forget to try some escargot, I mean when in Rome….I mean Paris, do as the Parisians would do! Escargot is french for snail, and is a very popular starter. It is most commonly cooked with garlic, butter and parsley. I really enjoy this dish, but keep in mind that it is really chewy. That can definitely be a problem for some, but if you can get over that you're eating snails, you should definitely give it a go.
Another delicious starter is Fois gras, which is made with the liver of a duck or goose that has been specially fattened. The Fois gras here was pan seared and served with an espresso sauce. It was extremely tasty with the crusty baguette we were given.
As I mentioned before, I love the freshness of the French ingredients. Here is a charred goat cheese salad, and everything had bright natural flavors. It was excellent.
So on to the main dishes. Steak Frites (which you will see in many restaurants), is comprised of an entrecôte (also known as rib eye) and is served with potatoes (often french fries, but it can also be oven roasted). This is almost always a delicious and filling meal in my opinion.
You will also find Steak Frites served with a sauce, in this case there was a mushroom sauce. We we have also had it with a black peppercorn sauce which is always a winner.
You will find a ton of duck dishes all over Paris, I definitely saw more duck items than chicken. The bright side of that is that duck is so delicious! You can try dishes such as: Duck a l'orange, Duck confit, and Magret de Canard (Seared Duck breast) to name a few.
This was a seared duck breast with balsamic reduction and a light side salad.
This is Duck confit, and my favorite thing about this dish is that it is so flavorful and the duck is fall off the bone tender.
For something quick and simple you can't beat the Croque Monsier. The Croque Monsier is a sandwich that contains ham and is topped with cheese and the whole sandwich is baked or pan fried. If you want something even more, you can try the Croque Madame, which is the same thing with the addition of a fried egg on top!
Here are some other French classics. Roasted chicken, or in this case roasted guinea fowl alongside mashed cauliflower.
And don't underestimate the beautifully crafted burgers. So full of flavor and really meaty!
Finally, I can't emphasize this enough, SAVE ROOM FOR DESSERT! You'll be sorry if you don't. Here is the Apple Millfeulle dessert we had at Le Bistro du Perigord. I cannot begin to tell you how delicious this was. The layers were flakey, the ice cream was amazing, the caramel was perfect and the flavors were definitely a harmonious combination. I still dream of this dessert.
If you don't have dessert during mealtime, don't panic, there are plenty of bakeries with sweets to be had. Here are some of the items at Pierre Hermes. Pierre Herme is well known for their beautifully crafted desserts and they unique flavors. We purchased quite a few macarons from them. They have amazing flavors like Passion Fruit and chocolate, Jasmine Tea, and more.
Overall, Parisian food is heavenly. It's a wonder that Scott and I were able to still fit in our clothes when we got home. So when you go to Paris make sure you walk a lot, eat a lot, and just soak up the wonderful French culture. You won't regret it!
Here are 2 restaurants we really enjoyed, they were both fabulous and we had a great dinner. I would definitely recommend making reservations if you can.


text:
You are here: Home / Award Shows / Front Page / News / Taylor Swift Cleans House at BBMAs on Sunday Night
Taylor Swift Cleans House at BBMAs on Sunday Night
Not only did 25-year old superstar singer/songwriter Taylor Swift release her new music video for "Bad Blood" at last night's Billboard Music Awards hosted by Ludacris and Chrissy Teigen, but the country-turned-pop singer absolutely cleaned house once the awards started…
Not only did 25-year old superstar singer/songwriter Taylor Swift release her new music video for "Bad Blood" at last night's Billboard Music Awards hosted by Ludacris and Chrissy Teigen, but the country-turned-pop singer absolutely cleaned house once the awards started being handed out.
Swift, nominated for 14 different awards, brought home the hardware in eight different categories, most notably for Top Artist, Top Female Artist, Top Billboard 200 Album (1989) and the Billboard Chart Achievement Award.
And to top it all of, as she walked up on stage to accept awards eight different times, Swift was caught getting comfy with 31-year old producer/DJ Calvin Harris each time. I guess we can put to rest any rumors about the two being together, huh?
You can check out the brand-new Bad Blood music video (featuring Kendrick Lamar) of hers below:
Photo: ngonoo
Tag Award Shows Bad Blood Music Video Billboard Music Awards Taylor Swift
Ben Heck
Ben is a 23-year old communications major (with a track in media production) at Salisbury University––located in Salisbury, MD. He's just one semester shy of finishing his degree, as he's set to graduate in December 2015. Ben grew up in Centreville, MD as a huge sports fan. He owns and operates two sports websites (All-Out Blitz and Ahead in the Count) in addition to Music Overload. He has already accomplished quite a bit in the sports media industry, so now he's looking to make an impact within the music and entertainment media industry with M-O.
Country Singer/Songwriter Kelly Seidel Speaks with Music Overload
Check it Out: Imagine Dragon's Touching Tribute to B.B. King at Billboard Music Awards


text:
The importance of fair and sustainable tourism for all: a central ally for reconstruction and recovery.
25 years after its adoption, the Montreal Declaration "Towards a humanist, social vision of tourism" is still relevant to today's tourism challenges and it is the basis of ISTO's DNA which proposes a model for the transformation and recovery of tourism.
Jean Marc Mignon
Honorary President of ISTO and Member of the UNWTO World Committee on Tourism Ethics
Jean Marc, now retired, has devoted his entire career to the youth and social tourism sectors, of which he was a committed actor.
In France, he directed the international youth exchange association Club des 4 Vents until 1990 and then the Union Nationale des Associations de Tourisme (UNAT) until 2010. At the international level, he was for 10 years (1987-1997) president of the Federation of International Youth Travel Organizations (FIYTO), then very involved in BITS, which became ISTO today. Vice-president from 1990 to 1998 and from 2002 to 2010, he was then president from 2010 to 2018. In this capacity, he was very involved in the drafting of the Montreal Declaration of 1996, and much later, very active in the rapprochement with the responsible tourism sector, which took place in 2016. Since 2013, and until autumn 2021, he is a member of the World Tourism Organisation's World Committee on Tourism Ethics.
See speech
Jacques Rayet - ISTO 23-06-2021
Latest News .
Best practices, Children, Domestic tourism, ISTO, Mobility, Policies, Public authorities, Sustainability, Sustainable Development Goals, Tourism, Youth 30-Jan-2023
ISTO Europe reaffirms its commitment to youth tourism
ISTO, Social, Sustainability, Sustainable Development Goals, Tourism, Tourism for all 27-Jan-2023
Brainstorming Days 2023: ISTO's Executive Committee met in Brussels
Accessibility, Best practices, Disability, Disadvantaged social groups, Education, Gender equity, Host communities, Inclusion, Responsible tourism 5-Jan-2023
Why Madhya Pradesh is a model of gender equality and inclusion to reproduce?


text:
Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling
Hsin Yuan Cheng, Anping Dong, Manikandan Panchatcharam, Paul Mueller, Fanmuyi Yang, Zhenyu Li, Gordon Mills, Jerold Chun, Andrew J. Morris, Susan S. Smyth
Objective-: Lysophosphatidic acid (LPA) is a bioactive lipid molecule produced by the plasma lysophospholipase D enzyme autotaxin that is present at ≥100 nmol/L in plasma. Local administration of LPA promotes systemic arterial remodeling in rodents. To determine whether LPA contributes to remodeling of the pulmonary vasculature, we examined responses in mice with alterations in LPA signaling and metabolism. Methods and Results-: Enpp2 +/- mice, which are heterozygous for the autotaxin-encoding gene and which have reduced expression of autotaxin/lysophospholipase D and approximately half normal plasma LPA, were hyperresponsive to hypoxia-induced vasoconstriction and remodeling, as evidenced by the development of higher right ventricular (RV) systolic pressure, greater decline in peak flow velocity across the pulmonary valve, and a higher percentage of muscularized arterioles. Mice lacking LPA 1 and LPA 2, 2 LPA receptors abundantly expressed in the vasculature, also had enhanced hypoxia-induced pulmonary remodeling. With age, Lpar1 -/-2 -/- mice spontaneously developed elevated RV systolic pressure and RV hypertrophy that was not observed in Lpar1 -/- mice or Lpar2 -/- mice. Expression of endothelin-1, a potent vasoconstrictor, was elevated in lungs of Lpar1 -/-2 -/- mice, and expression of endothelinB receptor, which promotes vasodilation and clears endothelin, was reduced in Enpp2 +/- and Lpar1 -/-2 -/- mice. Conclusion-: Our findings indicate that LPA may negatively regulate pulmonary vascular pressure through LPA 1 and LPA 2 receptors and that in the absence of LPA signaling, upregulation in the endothelin system favors remodeling.
Arteriosclerosis, Thrombosis, and Vascular Biology
https://doi.org/10.1161/ATVBAHA.111.234708
Lysophosphatidic Acid Receptors
Ventricular Pressure
4 alpha-glucanotransferase
lysophosphatidic acid
Right Ventricular Hypertrophy
Vasoconstrictor Agents
Endothelin-1
Vasoconstriction
Vasodilation
autotaxin
lysophospahtidic acid
Cheng, H. Y., Dong, A., Panchatcharam, M., Mueller, P., Yang, F., Li, Z., ... Smyth, S. S. (2012). Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(1), 24-32. https://doi.org/10.1161/ATVBAHA.111.234708
Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. / Cheng, Hsin Yuan; Dong, Anping; Panchatcharam, Manikandan; Mueller, Paul; Yang, Fanmuyi; Li, Zhenyu; Mills, Gordon; Chun, Jerold; Morris, Andrew J.; Smyth, Susan S.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 32, No. 1, 01.01.2012, p. 24-32.
Cheng, HY, Dong, A, Panchatcharam, M, Mueller, P, Yang, F, Li, Z, Mills, G, Chun, J, Morris, AJ & Smyth, SS 2012, 'Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 1, pp. 24-32. https://doi.org/10.1161/ATVBAHA.111.234708
Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z et al. Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012 Jan 1;32(1):24-32. https://doi.org/10.1161/ATVBAHA.111.234708
Cheng, Hsin Yuan ; Dong, Anping ; Panchatcharam, Manikandan ; Mueller, Paul ; Yang, Fanmuyi ; Li, Zhenyu ; Mills, Gordon ; Chun, Jerold ; Morris, Andrew J. ; Smyth, Susan S. / Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2012 ; Vol. 32, No. 1. pp. 24-32.
@article{7f2a91eb2ebe4dc3b1727f0d8df6ad47,
title = "Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling",
abstract = "Objective-: Lysophosphatidic acid (LPA) is a bioactive lipid molecule produced by the plasma lysophospholipase D enzyme autotaxin that is present at ≥100 nmol/L in plasma. Local administration of LPA promotes systemic arterial remodeling in rodents. To determine whether LPA contributes to remodeling of the pulmonary vasculature, we examined responses in mice with alterations in LPA signaling and metabolism. Methods and Results-: Enpp2 +/- mice, which are heterozygous for the autotaxin-encoding gene and which have reduced expression of autotaxin/lysophospholipase D and approximately half normal plasma LPA, were hyperresponsive to hypoxia-induced vasoconstriction and remodeling, as evidenced by the development of higher right ventricular (RV) systolic pressure, greater decline in peak flow velocity across the pulmonary valve, and a higher percentage of muscularized arterioles. Mice lacking LPA 1 and LPA 2, 2 LPA receptors abundantly expressed in the vasculature, also had enhanced hypoxia-induced pulmonary remodeling. With age, Lpar1 -/-2 -/- mice spontaneously developed elevated RV systolic pressure and RV hypertrophy that was not observed in Lpar1 -/- mice or Lpar2 -/- mice. Expression of endothelin-1, a potent vasoconstrictor, was elevated in lungs of Lpar1 -/-2 -/- mice, and expression of endothelinB receptor, which promotes vasodilation and clears endothelin, was reduced in Enpp2 +/- and Lpar1 -/-2 -/- mice. Conclusion-: Our findings indicate that LPA may negatively regulate pulmonary vascular pressure through LPA 1 and LPA 2 receptors and that in the absence of LPA signaling, upregulation in the endothelin system favors remodeling.",
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author = "Cheng, {Hsin Yuan} and Anping Dong and Manikandan Panchatcharam and Paul Mueller and Fanmuyi Yang and Zhenyu Li and Gordon Mills and Jerold Chun and Morris, {Andrew J.} and Smyth, {Susan S.}",
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AU - Morris, Andrew J.
AU - Smyth, Susan S.
N2 - Objective-: Lysophosphatidic acid (LPA) is a bioactive lipid molecule produced by the plasma lysophospholipase D enzyme autotaxin that is present at ≥100 nmol/L in plasma. Local administration of LPA promotes systemic arterial remodeling in rodents. To determine whether LPA contributes to remodeling of the pulmonary vasculature, we examined responses in mice with alterations in LPA signaling and metabolism. Methods and Results-: Enpp2 +/- mice, which are heterozygous for the autotaxin-encoding gene and which have reduced expression of autotaxin/lysophospholipase D and approximately half normal plasma LPA, were hyperresponsive to hypoxia-induced vasoconstriction and remodeling, as evidenced by the development of higher right ventricular (RV) systolic pressure, greater decline in peak flow velocity across the pulmonary valve, and a higher percentage of muscularized arterioles. Mice lacking LPA 1 and LPA 2, 2 LPA receptors abundantly expressed in the vasculature, also had enhanced hypoxia-induced pulmonary remodeling. With age, Lpar1 -/-2 -/- mice spontaneously developed elevated RV systolic pressure and RV hypertrophy that was not observed in Lpar1 -/- mice or Lpar2 -/- mice. Expression of endothelin-1, a potent vasoconstrictor, was elevated in lungs of Lpar1 -/-2 -/- mice, and expression of endothelinB receptor, which promotes vasodilation and clears endothelin, was reduced in Enpp2 +/- and Lpar1 -/-2 -/- mice. Conclusion-: Our findings indicate that LPA may negatively regulate pulmonary vascular pressure through LPA 1 and LPA 2 receptors and that in the absence of LPA signaling, upregulation in the endothelin system favors remodeling.
AB - Objective-: Lysophosphatidic acid (LPA) is a bioactive lipid molecule produced by the plasma lysophospholipase D enzyme autotaxin that is present at ≥100 nmol/L in plasma. Local administration of LPA promotes systemic arterial remodeling in rodents. To determine whether LPA contributes to remodeling of the pulmonary vasculature, we examined responses in mice with alterations in LPA signaling and metabolism. Methods and Results-: Enpp2 +/- mice, which are heterozygous for the autotaxin-encoding gene and which have reduced expression of autotaxin/lysophospholipase D and approximately half normal plasma LPA, were hyperresponsive to hypoxia-induced vasoconstriction and remodeling, as evidenced by the development of higher right ventricular (RV) systolic pressure, greater decline in peak flow velocity across the pulmonary valve, and a higher percentage of muscularized arterioles. Mice lacking LPA 1 and LPA 2, 2 LPA receptors abundantly expressed in the vasculature, also had enhanced hypoxia-induced pulmonary remodeling. With age, Lpar1 -/-2 -/- mice spontaneously developed elevated RV systolic pressure and RV hypertrophy that was not observed in Lpar1 -/- mice or Lpar2 -/- mice. Expression of endothelin-1, a potent vasoconstrictor, was elevated in lungs of Lpar1 -/-2 -/- mice, and expression of endothelinB receptor, which promotes vasodilation and clears endothelin, was reduced in Enpp2 +/- and Lpar1 -/-2 -/- mice. Conclusion-: Our findings indicate that LPA may negatively regulate pulmonary vascular pressure through LPA 1 and LPA 2 receptors and that in the absence of LPA signaling, upregulation in the endothelin system favors remodeling.
KW - autotaxin
KW - lipids
KW - lysophospahtidic acid
KW - pulmonary artery
KW - pulmonary hypertension
U2 - 10.1161/ATVBAHA.111.234708
DO - 10.1161/ATVBAHA.111.234708
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
10.1161/ATVBAHA.111.234708


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All the children are in the age group of 6 to 14 years and majority of them are out of school. After NARMADA's intervention some of the children have been enrolled in Government schools. The centres run for 4 hours during the day after which the children help their parents out in the fields or tend the cattle.
Students of several government-run middle schools and high schools in the region do not have science lab facilities. They cannot perform science experiments. They have to depend only on textbooks to write answers to questions in the examinations. They thus lag behind their urban counterparts. More important, they do not develop scientific temperament.
NARMADA has undertaken a modest initiative to overcome these lacunae by starting a mobile science Laboratory. A van carrying scientific equipment visits nearby villages as per a well-laid out schedule. Science experiments are demonstrated to the middle school students who can carry out the experiments under the guidance of the teachers and our volunteers.


text:
Tag: POTUS
Russia, China, North Korea, and the "Rodney Dangerfield" President
On March 19, 2021 March 19, 2021 By kingsjesterIn PoliticsLeave a comment
I don't get no respect – Rodney Dangerfield
Russian President Vladimir Putin challenged President Biden to an on-air conversation to discuss Biden's latest warning that Putin would "pay a price," following a report containing evidence of attempted Russian-interference in the 2020 election.
"I've just thought of this now," Putin told a reporter in Moscow Thursday. "I want to invite President Biden to continue our discussion, but on the condition that we do it actually live. But with no delays, directly in an open, direct discussion."
Putin said that as the world's two leading superpowers, he thought the dialogue would prove interesting for the U.S. and Russian people, as well as for the international community.
Biden made headlines this week after an interview with ABC's George Stephanopoulos, when the president was asked if he thought Putin was a "killer," to which he answered "I do."
Putin responded Thursday by saying, "It takes one to know one."
The White House did not immediately return Fox News' questions on whether Biden intends to speak publically with Putin.
In a press briefing Thursday, White House press secretary Jen Psaki, when asked by reporters if Biden regretted his remarks, Psaki said, "Nope."
"The president gave a direct answer to a direct question," she added.
Putin suggested holding the live conversation as soon as Friday or Monday, adding that he wants to "relax a little" this weekend by heading to the forested region in northern Russia, known as the tiaga.
"We are ready any time that is convenient for the American side," he added.
A declassified report released Tuesday by the U.S. Office of the Director of National Intelligence, found that while no foreign powers "manipulated any election results," Russia sought to influence public opinion in opposition of Biden.
"The price he is going to pay, well, you'll see shortly," Biden threatened.
Russia recalled its ambassador to the United States following the president's remarks.
Meanwhile, Newsmax.com reported that
Top U.S. and Chinese officials offered sharply different views of each other and the world on Thursday as the two sides met face-to-face for the first time since President Joe Biden took office.
In unusually pointed remarks for a staid diplomatic meeting, Secretary of State Antony Blinken and Chinese Communist Party foreign affairs chief Yang Jiechi took aim at each other's country's policies at the start of two days of talks in Alaska.
The contentious tone of their public comments suggested the private discussions would be even more rocky.
The Chinese foreign affairs chief slammed Biden, remarking…
"We believe that it is important for the United States to change its own image and to stop advancing its own democracy in the rest of the world," he said. "Many people within the United States actually have little confidence in the democracy of the United States."
And, finally, CNBC.com reported that
The powerful sister of North Korean leader Kim Jong Un sent an eerie message to the United States on Tuesday, as Biden administration officials arrive for high-level talks in Japan and South Korea.
"We take this opportunity to warn the new U.S. administration trying hard to give off [gun] powder smell in our land," Kim Yo Jong said in a statement referencing joint U.S. and South Korean military exercises in the region.
"If it [the U.S.] wants to sleep in peace for the coming four years, it had better refrain from causing a stink at its first step," she added, according to an English translation.
Other that that, the entire world loves and respects Sleepy Joe.
I really do not know what Biden's Handlers and the Democrat elite think that they are accomplishing by using dementia-riddled, doddering old Joe Biden as a puppet sitting in the Oval Office.
Putin just told the entire world that Biden is impaired and could not possibly handle a live discussion with him.
Then, the Chinese foreign affairs chief hit the nail on the head when he made his comment about the lack of "confidence in the democracy of the United States", a veiled reference to the 2020 Presidential Election, which was stolen by the Democrats.
And finally, Kim Jong Un's crazy sister out-and-out threatened us.
Our enemies do not respect Biden the way that they did President Trump.
How could they?
They watched the videos of his campaign and his appearances then and now, as President.
They see how frail and impaired that he has become.
Their intelligence agencies have, no doubt, uncovered information about this whole charade, known as the Biden Presidency, which his Handlers and the Democrat Elite are desperately trying to keep hidden from the American people.
President Ronald Reagan famously said,
When you can't make them see the light, make them feel the heat.
There is no way that Joe Biden will ever gain the respect of our Sovereign Nation's enemies.
Heck, even as I write this, late on Thursday evening, they are probably still laughing over him identifying his Vice-President as "President Harris" earlier today.
We are so screwed.
Harris Taking Solo Calls With World Leaders as Biden Battles Memory Problems, Half of Americans are Not Confident in Biden's Fitness For the Job
On March 10, 2021 March 9, 2021 By kingsjesterIn Politics1 Comment
https://twitter.com/toddstarnes/status/1369368352834154510?s=20
Vice President Kamala Harris had another call with a foreign leader Tuesday, independent of President Biden.
Harris spoke with the prime minister of Norway, Erna Solberg, where Harris "affirmed her commitment to deepening the strong alliance between Norway and the United States."
" The Vice President thanked the Prime Minister for Norway's close security partnership with the United States and generous contributions to development and health security efforts around the world," according to a readout of the call.
Harris previously took calls alone with French President Emanuel Macron and Canadian Prime Minister Justin Trudeau as well as Israeli Prime Minister Benjamin Netanyahu, shortly after the president put in a call to the French and Canadian leaders himself.
Less than two months into the new administration, Harris' frequent solo calls with world leaders signal that she'll engage deeply even in foreign policy, though her experience has been almost entirely in the domestic realm. Leaders around the world could view the vice president as Biden's heir-apparent and be eager to build a relationship.
"She will be seen by everyone as a potential president in waiting," one European ambassador told Politico in February. "Much more than in previous presidencies."
In a related story from Newsmax.com…
Half of America doubts President Joe Biden is "physically or mentally" fit for the job, according to the latest poll by Rasmussen Reports.
It is an alarming finding after reports of President Biden failing to remember the name of Defense Secretary Lloyd Austin, calling him "the guy that runs that outfit over there," the New York Post reported Monday.
The 2-question survey asked:
"How concerned are you that President Biden has not held a press conference?"
"How confident are you that Joe Biden is physically and mentally up to the job of being President of the United States?"
The two might be related, and the responses were, too — as 50% of likely voters lacked confidence in President Biden's fitness for office, while 52% of likely voters were concerned he has yet to hold a press conference, including 32% who are "very concerned."
"More than six weeks since his inauguration, President Biden still hasn't held his first White House press conference, and half of voters are worried about his ability to do the job," the Rasmussen Reports summary read.
The headline from the FoxNews.com article states "VP Harris continues taking solo calls with world leaders as Biden struggles with memory lapses".
As I wrote yesterday, that was evident when he could not remember the names of the Pentagon and his Secretary of Defense in a military announcement seen on live television..
A lot of fun has been had at Biden's expense over the fact that he is losing his war with dementia.
However, in terms of the safety of our country's citizens and our nation's continued existence, it is definitely not a laughing matter.
Any American who paid attention during the campaign soon figured out that Biden has some serious mental and physical health issues.
It was one thing to over look his inappropriate behavior during the Obama Presidency when he was just the Vice-President and Obama, Susan Rice, and Valerie Jarret were running the show, anyway.
However, when the time came for Biden to start appearing during the Democrat Primaries and then, the Presidential Campaign itself, it was quite obvious that "Lunch Bucket Joe" was shy a potato chip or two.
Now, the President of the United States of America reminds average Americans of their relatives who live in nursing homes whom they have not seen in a while because they cannot bear to witness them deteriorating like Biden is.
HIs wife, "Dr." Jill Biden and the rest of his Handlers can try as hard as they can to hide his condition.
Unfortunately, as we have noticed, Joe is declining physically as well as mentally.
Vice-President Kamala Harris and the Democrat Elites know that Joe's time in the Oval Office is limited.
That is another reason why Harris is talking to world leaders directly.
She might as well be ready to assume the Presidency.
Biden's tenure as President will end before the year is out….perhaps by Fall.
POTUS Vs. The Police: Once a Community Organizer…
On December 1, 2014 December 2, 2014 By kingsjesterIn PoliticsLeave a comment
Liberals seem to assume that, if you don't believe in their particular political solutions, then you don't really care about the people that they claim to want to help. – Dr. Thomas Sowell
DATELINE: Chicago, January 31, 2013 –
With outrage over Hadiya Pendleton's slaying spreading from City Hall to the White House, the 15-year-old became a symbol Wednesday of escalating violence in Chicago while fueling the national debate over guns and crime.
A little more than a week after performing with the King College Prep band in Washington during President Barack Obama's inauguration festivities, Hadiya was fatally shot Tuesday afternoon in a park about a mile north of Obama's Kenwood home. Two other teens were wounded.
Young, talented Hadiya was killed by Chicago "Gang Bangers", who just happened to have been black.
How quickly they forget.
The New York Post reports that
Obama is proposing a three-year, $263 million spending package to increase use of body-worn cameras, expand training for law enforcement and add more resources for police department reform. The package includes $75 million for the small, lapel-mounted cameras to record police on the job.
The White House has said the cameras could help bridge deep mistrust between law enforcement and the public. It also potentially could help resolve the type of disputes between police and witnesses that arose in the Ferguson shooting.
After the shooting and resulting protests in August, Obama ordered a review of federal programs that fund military gear for local police after critics questioned why police in full body armor with armored trucks responded to dispel demonstrators. Obama seemed to sympathize when announcing the review over the summer.
"There is a big difference between our military and our local law enforcement and we don't want those lines blurred," Obama said at the time.
Senior administration officials said Friday that five federal agencies have programs to supply the equipment that are authorized by Congress, but Obama's focus is not supporting legislation to repeal them but to make sure there are standards to ensure the equipment is used safely.
Obama's staff is drafting an executive order that will require federal agencies that run the programs to work with law enforcement and civil rights and civil liberties organizations to recommend changes.
Demands for police to wear the cameras have increased across the country since Brown's death. Some officers in the St. Louis suburb have since started wearing the cameras, and the New York Police Department became the largest department in the US to adopt the technology when it launched a pilot program in early September.
A report from the Justice Department, which had been in the works before the Ferguson shooting, said there's evidence that both police and civilians behave better when they know there are cameras around. The report also cites how footage from the cameras can be used to train officers.
So, somehow, it's America's Law Enforcement Officers' Fault that a young thug got himself killed while attacking a police officer?
What ever happened to personal responsibility?
President Ronald Reagan once said,
There are no constraints on the human mind, no walls around the human spirit, no barriers to our progress except those we ourselves erect.
Compare it to these words:
It's not to make excuses for that fact — although black folks do interpret the reasons for that in a historical context. They understand that some of the violence that takes place in poor black neighborhoods around the country is born out of a very violent past in this country, and that the poverty and dysfunction that we see in those communities can be traced to a very difficult history. – President Barack Hussein Obama, 7/19/2014
President Obama, for his own political reasons, reinforces, at every opportunity, the self-fulfilling prophecy that the Black Community is still shackled and limited in their freedom.
Which is an ironic statement, considering, as a Black man, that he presently holds the position of President of the most powerful country on the face of the Earth.
On November 25th, The Daily Caller reported that
Retired neurosurgeon and potential GOP 2016 candidate Ben Carson believes race relations in America, as a whole, have "gotten worse" under President Barack Obama's leadership, saying he should take a "balanced, objective look at things" instead of invoking the race card.
Carson made the comments to conservative radio host Hugh Hewitt Tuesday night.
"I actually believe that things were better before this president was elected," Carson told Hewitt, "and I think that things have gotten worse because of his unusual emphasis on race."
"Can you explain more? What do you mean by that?" asked Hewitt. "How did they get worse, and how did he contribute to it?"
"Well, for instance, in the incident with Henry Louis Gates, Skip Gates and him calling out the police, and you know, how they always do this kind of thing, and the Trayvon Martin case, you know, if I had a son, this is what he would look like, rather than trying to take the balanced, objective look at things, and then, you know, what's happened here," responded Carson.
"And then the way, which really irritates me to some degree, the way he and a bunch of progressives manipulate, particularly minority communities, to make them feel that they are victims. And of course if you think you're a victim, you are a victim," Carson continued.
Back in High School, during the 1974-1975 school year, I was a Sophomore Commissioner on the Student Council with a fellow named James. James was one of those students who were bused to our school. He went on to play football and run track. More importantly, James went on to have a 4.5 GPA, make a 32 on his ACT, and receive a full scholarship to Harvard, and later, went on to Johns Hopkins Medical School. James worked hard and he achieved.
Millions of other Black Americans have, as well.
The current race-baiting and racially-based pandering by the President and his Administration dishonors those who have achieved and has constrained those who might otherwise achieve.


Please note that Matthew C. Morelli, a seminarian of the Diocese of Harrisburg, is being considered for the order of Priest.
This announcement is made in accordance with the law of the Church. If anyone knows of any reason why this person should not be ordained, they have an obligation in conscience to contact the pastor of this parish or Father Brian J. Wayne, Director of Vocations in the Diocese of Harrisburg as soon as possible.


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Antidepressant trials exclude most 'real world' patients with depression
By Wolters Kluwer Health July 14, 2015
Photo credit: Tom Varco
More than 80 percent of people with depression in the general population aren't eligible for clinical trials of antidepressant drugs, according to a study in the Journal of Psychiatric Practice. The journal is published by Wolters Kluwer.
At least five patients would need to be screened to enroll just one patient meeting the typical inclusion and exclusion criteria for antidepressant registration trials (ARTs), suggests the new research by Drs. Sheldon Preskorn and Matthew Macaluso of University of Kansas School of Medicine-Wichita and Dr. Madhukar Trivedi of Southwestern Medical School, Dallas. The study highlights some major differences between patients with depression seen in everyday clinical practice and those enrolled in ARTs–the studies of antidepressants that lead to FDA drug approval.
Most Patients with Major Depression Aren't Eligible for ARTs
Antidepressant registration trials use certain inclusion and exclusion criteria to create a group of patients with similar characteristics. These criteria increase the chances of detecting true drug effects, while reducing "false signals" of safety problems or side effects. For example, ARTs commonly exclude patients with other medical problems–if their illness worsened during the study, it might raise inaccurate safety concerns about the drug being studied.
To find out how these inclusion and exclusion criteria affect patient selection for ARTs, the researchers analyzed more than 4,000 patients from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Funded by the National Institute of Mental Health, STAR*D was the largest and longest study of depression treatment ever conducted. To ensure that the "real world" population of patients with depression was represented, STAR*D used minimal exclusion criteria.
The researchers found that more than 82 percent of STAR*D patients would not be eligible for enrollment in current ARTs, based on a list of "usual" inclusion and exclusion criteria. Fourteen percent would be excluded on the basis of age alone–that's because most ARTs exclude patients older than 65. Another 15 percent would be excluded because their depression was less severe than a commonly used cutoff point.
More than 20 percent of STAR*D patients would be excluded from ARTs because of a "clinically significant or unstable general medical condition." Twenty-one percent of women would be excluded because they were not using birth control to prevent pregnancy during the study.
Because many ARTs use stricter criteria, the true exclusion rate is probably even higher, the authors note. For example, more recent studies have used even higher severity thresholds for enrollment, which would eliminate more than 90 percent of the STAR*D population. The researchers also point out that all of the STAR*D patients had obviously agreed to participate in that research study–which is something many people with depression might be unwilling to do.
The researchers hope their work will help drug developers understand how inclusion and exclusion criteria may affect enrollment in ARTs, and help them in developing an appropriate recruitment plan and timeline. "The timelines in most drug studies are unrealistically short and their recruitment plans are often woefully inadequate, resulting in studies that take longer than expected to complete and frequent budget overruns," Drs. Preskorn, Macaluso, and Trivdei write. Failure to consider the effort needed for ART recruitment might lead to lost revenue, delays in bringing a drug to market, or failure to develop a potentially effective medication.
The findings may also help to explain to healthcare practitioners why ARTs tend to overestimate the benefits of antidepressant treatment in "real world" patients with depression. "Obviously," the researchers add, "the more patients who are excluded from the ARTs, the greater the chances that the results will not generalize to the routine clinical practice."