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Diabetic ketoacidosis | definition of diabetic ketoacidosis by Medical dictionary
https://medical-dictionary.thefreedictionary.com/diabetic+ketoacidosis
Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to diabetic ketoacidosis: diabetic diet, diabetic coma
Diabetic ketoacidosis is a dangerous complication of diabetes mellitus in which the chemical balance of the body becomes far too acidic.
Diabetic ketoacidosis (DKA) always results from a severe insulin deficiency. Insulin is the hormone secreted by the body to lower the blood sugar levels when they become too high. Diabetes mellitus is the disease resulting from the inability of the body to produce or respond properly to insulin, required by the body to convert glucose to energy. In childhood diabetes, DKA complications represent the leading cause of death, mostly due to the accumulation of abnormally large amounts of fluid in the brain (cerebral edema). DKA combines three major features: hyperglycemia, meaning excessively high blood sugar kevels; hyperketonemia, meaning an overproduction of ketones by the body; and acidosis, meaning that the blood has become too acidic.
Insulin deficiency is responsible for all three conditions: the body glucose goes largely unused since most cells are unable to transport glucose into the cell without the presence of insulin; this condition makes the body use stored fat as an alternative source instead of the unavailable glucose for energy, a process that produces acidic ketones, which build up because they require insulin to be broken down. The presence of excess ketones in the bloodstream in turn causes the blood to become more acidic than the body tissues, which creates a toxic condition.
DKA is most commonly seen in individuals with type I diabetes, under 19 years of age and is usually caused by the interruption of their insulin treatment or by acute infection or trauma. A small number of people with type II diabetes also experience ketoacidosis, but this is rare given the fact that type II diabetics still produce some insulin naturally. When DKA occurs in type II patients, it is usually caused by a decrease in food intake and an increased insulin deficiency due to hyperglycemia.
Some common DKA symptoms include:
frequent urination (polyuria) and thirst
fatigue and lethargy
fruity odor to breath
rapid, deep breathing
muscle stiffness or aching
Diagnosis requires the demonstration of hyperglycemia, hyperketonemia, and acidosis. DKA is established if the patient's urine or blood is strongly positive for glucose and ketones. Normal glucose levels in a non-diabetic person on average range from 80-110 mg/dl. A person with diabetes will typically fluctuate outside those parameters. DKA glucose levels exceed 250 mg/dl and can reach 400 to 800 mg/dL. A low serum bicarbonate level (usually below 15 mEq/L) is also present, indicative of acidosis.
A blood test or urinalysis can quickly determine the concentration of glucose in the bloodstream. Test strips are available to patients commercially can submerge in urine to detect the presence or concentration of ketones.
Acidosis — A condition that causes the pH of the blood to drop and become more acidic.
Diabetes mellitus — Disease characterized by the inability of the body to produce or respond properly to insulin, required by the body to convert glucose to energy.
Edema — The presence of abnormally large amounts of fluid in the intercellular tissue spaces of the body.
Glucose — The type of sugar found in the blood.
Hyperglycemia — Condition characterized by excessively high levels of glucose in the blood, and occurs when the body does not have enough insulin or cannot use the insulin it does have to turn glucose into energy. Hyperglycemia is often indicative of diabetes that is out of control.
Hyperketonemia — Condition characterized by an overproduction of ketones by the body.
Hypoglycemia — Lower than normal levels of glucose in the blood.
Hypokalemia — A deficiency of potassium in the blood.
Insulin — A hormone secreted by the pancreas in response to high blood sugar levels that induces hypoglycemia. Insulin regulates the body's use of glucose and the levels of glucose in the blood by acting to open the cells so that they can intake glucose.
Ketones — Poisonous acidic chemicals produced by the body when fat instead of glucose is burned for energy. Breakdown of fat occurs when not enough insulin is present to channel glucose into body cells.
Lactic acidosis — A serious condition caused by the build up of lactic acid in the blood, causing it to become excessively acidic. Lactic acid is a by-product of glucose metabolism.
Metabolism — The sum of all chemical reactions that occur in the body resulting in growth, transformation of foodstuffs into energy, waste elimination, and other bodily functions.
Polyuria — Excessive secretion of urine.
Type I diabetes — Also called juvenile diabetes. Type I diabetes typically begins early in life. Affected individuals have a primary insulin deficiency and must take insulin injections.
Type II diabetes — Type II diabetes is the most common form of diabetes and usually appears in middle aged adults. It is often associated with obesity and may be delayed or controlled with diet and exercise.
Ketoacidosis is treated under medical supervision and usually in a hospital setting.
Basic treatment includes:
administering insulin to correct the hyperglycemia and hyperketonemia
replacing fluids lost through excessive urination and vomiting intravenously
balancing electrolytes to re-establish the chemical equilibrium of the blood and prevent potassium deficiency (hypokalemia) during treatment
treatment for any associated bacterial infection
With proper medical attention, DKA is almost always successfully treated. The DKA mortality rate is about 10%. Coma on admission adversely affects the prognosis. The major causes of death are circulatory collapse, hypokalemia, infection, and cerebral edema.
Once diabetes has been diagnosed, prevention measures to avoid DKA include regular monitoring of blood glucose, administration of insulin, and lifestyle maintenance. Glucose monitoring is especially important during periods of stress, infection, and trauma when glucose concentrations typically increase as a response to these situations. Ketone tests should also be performed during these periods or when glucose is elevated.
American Diabetes Association. 1701 North Beauregard Street, Alexandria, VA 22311. (800) DIABETES (800-342-2383). http://www.diabetes.org/.
Juvenile Diabetes Foundation. 120 Wall St., 19th Floor, New York, NY 10005. (800) 533-CURE. http://www.jdf.org/.
National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK). 31 Center Drive, MSC 2560, Bethesda, MD 20892-2560. http://www.niddk.nih.gov.
diabetic ketoacidosis (DKA),
buildup of ketones in blood due to breakdown of stored fats for energy; a complication of diabetes mellitus. Untreated, can lead to coma and death.
See ketoacidosis.
A hyperglycemia-induced clinical crisis most common in type 1 DM Clinical N&V, thirst, diaphoresis, hyperpnea, drowsiness, fever, prostration, coma, possibly death Lab ↑↑↑ Glucose, often > 33.6 mmol/L–US: > 600 mg/dL, ↑ ketone bodies, relative ↑ in protein, albumin, Ca2+, BR, alk phos, AST, CK, anion gap, acidosis, dehydration, ↓ K+, Na+, phosphate Management Insulin, fluid and electrolyte replacement, treat initiating factors–eg, leukocytosis or hypothermia, avoid complications–eg, hypokalemia, late hypoglycemia
di·a·betic ke·to·a·ci·do·sis
(DKA) (di-ă-bet'ik kē'tō-as'i-dō'sis)
diabetic ketoacidosis
acidotic
albiglutide
alcoholic ketoacidosis
alveolar edema
Avandia
bacterial esophagitis
bedside glucose monitoring
beta-hydroxybutyric acid
bronze diabetes
carbon dioxide acidosis
Treatment of diabetic ketoacidosis (DKA)/hyperglycemic hyperosmolar state (HHS): Novel advances in the management of hyperglycemic crises (UK versus USA).
Audit of diabetic ketoacidosis management at a tertiary hospital in Johannesburg, South Africa
Diabetic Ketoacidosis Occurring in Patient on Newly Started Insulin Glargine U300.
Diabetic Ketoacidosis Occurring in Patient on Newly Started Insulin Glargine U300
Acute pancreatitis secondary to diabetic ketoacidosis induced hypertriglyceridemia in a young adult with undiagnosed type 2 diabetes.
Acute pancreatitis secondary to hypertriglyceridemia precipitated by diabetic ketoacidosis in a previously undiagnosed ketosis-prone patient with diabetes mellitus
Thrombotic microangiopathic syndrome: a novel complication of diabetic ketoacidosis. Indian Pediatr.
Spectrum of complications of severe DKA in children in pediatric Intensive Care Unit
Abbreviations DKA: Diabetic ketoacidosis ICU: Intensive care unit PD-1: Antiprogrammed death 1 receptor PD-1L: Programmed death ligand GADA: Glutamic acid decarboxylase autoantibodies IAA: Insulin autoantibodies IA-2A: Islet antigen 2 autoantibodies ICA: Islet cell antibodies ZnT8A: Zinc transporter 8 autoantibodies.
Fulminant Diabetes in a Patient with Advanced Melanoma on Nivolumab
Wykretowicz, "The DKA that wasn't: a case of euglycemic diabetic ketoacidosis due to empagliflozin," Oxford Medical Case Reports, vol.
Newer Perspectives of Mechanisms for Euglycemic Diabetic Ketoacidosis
Diabetic ketoacidosis is defined by the presence of blood glucose levels greater than 250 mg/dL, being this the main finding, associated with metabolic acidosis (pH < 7.3 and serum bicarbonate < 15 mEq/dL) with an increased anion gap and the presence of ketone bodies in the blood and/or urine [1].
Euglycemic Diabetic Ketoacidosis in the ICU: 3 Case Reports and Review of Literature
Belanger et al., "Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state," Canadian Medical Association Journal, vol.
A Rare and Lethal Complication: Cerebral Edema in the Adult Patient with Diabetic Ketoacidosis
The patient was started on an insulin drip for diabetic ketoacidosis. The isoproterenol was discontinued, and a pacemaker was placed.
Isoproterenol Induced Insulin Resistance Leading to Diabetic Ketoacidosis in Type 1 Diabetes Mellitus
It is thought that it generally develops secondary to electrolyte imbalance as with the other cardiac complications of diabetic ketoacidosis (3, 4).
Electrocardiographic changes in children with diabetic ketoacidosis and ketosis
Alex Wellington become seriously unwell with diabetic ketoacidosis
Teen left fighting for his life due to Type 1 diabetes
diabetic acidosis
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Diabetic neuropathies


Maria O'Brien's new body of work, created during her residency in The Laois Arthouse from August 2014 to present, reveals a renewed exploration into landscape for the artist. By working directly from photographs, found mostly on social media, the artist offers us glimpses into other people's worlds. The artist produces small scale paintings in oil on primed paper which allows her to work quickly without being too rigid and is reflective of her vast and ever increasing body of research. By painting these glimpses into other peoples' lives, a new form of existence is being offered to them.
Today there is visual over-saturation. Social media bombards us with the mundane and the fantastic (one often melding into the other). By painting images that would otherwise be scrolled through quickly or swiped past in an instant, O'Brien gives new life to the captured seconds and the people and actions they contain. One has to give pause to consider O'Brien's studies of these everyday instances and the gravity given to them by her time and attention. Seeing these moments in paint we are forced to slow down and observe. The artist seeks to capture them and by doing so elongates a moment in time.
'On My Green Way I Wend' explores humans engaging recreationally with the outdoors – using nature for their own diversion and entertainment with all the paraphernalia this involves. What the viewer is privy to is human and nature, not quite as one but relating to each other. O'Brien's fluid style further emphasises this, both figure and landscape are often given the same treatment, the same brushstroke. The texture of the human does not differ from that of the surrounding terrain that they inhabit, even though they are often at odds. This serves to highlight our attempt to control the natural world, the sports equipment and its deceptively simple representation offer humorous insight into this struggle.
The Tipperary born artist is fascinated with landscape, but does not revere it. Her countryside is useful; it is accessible and it is for everyone. It is not a remote or abstract place; it is real. Action shots are painted quickly and deftly capturing the energy and spontaneity of the interaction between humans and their surrounds. She is working impromptu, from a moment captured by a stranger. Palette and a brushstroke are directly influenced by the light and action of her chosen setting.
In paintings such as 'Canoeist Pausing', 'Tiny Skier' and 'Pepper Canisters' one can sense a yearning for the sublime, but not quite the sublime of Friedrich's 'Wanderer Above the Sea of Fog'. O'Brien's use of humour; the poses of the people, the handling of paint to somewhat distort the humans, the use of social media images to feed her work all reflect more of a kitsch look at the sublime, a less reverent take on what the representation of an ideal is and should look like.
In the 'Tiny Skier', the figure is poised under a stormy, threatening sky and looks as though they are about to be subsumed by the enormity of the surrounding landscape. The figure in 'Tiny Skier' was created with only a few hairs of a brush, yet the self-conscious pose and the excitement in waiting for the photo to be taken is all translated to the viewer. The proximity between the sublime and the absurd is successfully alluded to.
O'Brien uses paint astutely to evoke light, her quick, broad brushstrokes allow little space for detail but lends itself strikingly to create atmosphere. In 'Snowmobiles at Night', she conveys the winter scene though her deliberate application of tones, using a limited palette of white, violet, indigo and paynes grey. In 'Parasols in Sugar Beach', a sultry scene is captured faithfully. The painting faces us as though through a filter, a nod to the medium from which this image was sourced and the many possibilities of contemporary, personal photography. This brings to mind again the pretense and showmanship involved in using social media, the manipulation and construction involved and how these constructs are quantified, dismantled and understood by the viewer. As it turns out, Sugar Beach itself is a construct, it is an entirely man-made urban beach park in Toronto, swimming and water sports are not allowed here, the beach is not functional and was made purely for aesthetic purposes.
We see how O'Brien's use of titles situate the artist at a distance from the people who populate her paintings. That is not to say that she does not empathise with them, it is clear that she does from the very fact that they have made it into her body of work. It is more that titles do not let us forget that we are looking upon people who have been gleaned from the web pages of social media.
Throughout 'On My Green Way I Wend' O'Brien is drawing attention to how bizarre the human struggle to engage with nature often seems. She highlights this through her palette, the often ostentatious coloured garb jumps out against the natural background. She is painting people who want to be seen; a basic human desire. As much as wanting to be seen is innate in human nature, so is wanting to watch others, in the artist's case painting the memories of perfect strangers. It is through her observation of the human in their surrounds, through her choice of content and rich surface, that the artist has created a new platform from which we, the audience, can vicariously people-watch ourselves.
Siobhán Mooney is a curator and writer based in Dublin.


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Heh, I have T-Mobile....... the plot thickens!
Yeah, I mean the option is most definitely built-in to the APK. I've extracted it and I can see it there. I'm really curious why it's hiding itself. It's also crazy that this isn't a larger issue. I agree, I've never seen such action in Android before.
I haven't tried changing my APN - but maybe it's worth a shot? It really makes no sense whatsoever. I'm wondering if it has something to do with my physical SIM card. Let me know if using your girlfriends changes anything up.
Can you test something out for me real quick? Go to Settings->About Phone->Status -- what does it say for "My Phone Number" ?
Says Unknown. It's been like that for as long as I can remember.
That's exciting! I'll see if I can figure out anything on this end. People are saying iPhone's have the ability to add a number to sim, unfortunately I don't have any just sitting around.
It doesn't stick on reboot but hey, I don't mind! Thanks for figuring out the key to getting group mms to work. Can't tell you how many hairs I pulled out trying to fix it.
Ahh good find dude. My SIM is programmed with my number so i guess that's why mine shows up just fine. With some older phones you can manually edit your number on the SIM. My old Motorola phone could do that if i remember correctly.
I checked my status and my number was indeed unknown. Popped my SIM card into my old samsung slider phone. Set my number, and put it back in my Galaxy Nexus. Option is there now. Pennin you are awesome.
How would I change my phone number on the sim card without having another phone to set the number? Is it something I can have tmobile do?


This fortnight Patter challenged us in her devotion to look at ourselves and see if we are growing in our faith. Sometimes I feel I am and other times I feel like I am slipping backwards or stagnating. I know how to remedy this..... get stuck into more reading and studying of God's Word.
I used my page this time for a Font Challenge on my favourite digital scrapbooking forum - Nuts 4 Digi. The font we were given in the challenge is Impact Label which looks like dymo tape.
The digital kit I used for my page is French Market by Syndee Nuckles.
Very nice :) I like the rich gold and maroon colours, and the stitching.
Oh, what a wonderful page! This verse is so good for this grow study! Your purpose page below is also great!! Pretty work!
Oh I remember... last time I was here, I couldn't post for some reason. I came this time to say that I still love it!


After the unseemly scuffle between rival Germans over who was going to pinch which bit of the auto Crown Jewels, it was BMW who emerged clutching Rolls-Royce. Sacrilege? Not if you judge them by their wholly British factory at Goodwood and the imperiously true-to-the-history luxo-barges it lovingly produces.


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India Meteorological Department Will Use Artificial Intelligence For Weather Forecasting
How This AI Model Can Get Students Back In School Premise In The Post-COVID World
Even though the use of AI in weather forecasting is not widely adopted, it has gained traction in the recent years. According to many media reports, The India Meteorological Department (IMD) is aiming at utilising artificial intelligence in weather forecasting. Various tools can be used like radars and satellite footage for in-depth analysis and prediction of weather events based on AI modelling.
The use of AI here is particularly focused on issuing nowcasts, which can help in almost real time (3-6 hours) prediction of drastic weather episodes, the Director-General Mrutunjay Mohapatra stated last week. IMD may also conduct collaborative research on use of AI for weather forecasting along with other institutions in India. Thus, IMD has invited research firms to evaluate how AI be of value to enhance weather forecasting and even the Ministry of Earth Sciences is looking into its use in various weather-related projects.
Weather forecasting has typically been done by physical models of the atmosphere, which are uncertain to perturbations, and therefore are erroneous for big periods of time. Since machine learning methods are more robust against perturbations, researchers have been investigating their application in weather forecasting to produce more precise weather predictions for substantial periods of time.
For example, take a look at "Machine Learning for Precipitation Nowcasting from Radar Images," where Google presented new research into the development of machine learning models for precipitation forecasting that addresses this challenge by making highly localised "physics-free" predictions that apply to the immediate future.
"Artificial intelligence helps in understanding past weather models and this can make decision-making faster," Mohapatra told PTI.
The predictions of extreme weather phenomenon can be of tremendous value in minimising the damage caused, and plan ahead to prevent casualties. Here, the role of IMD is critical in planning against weather-relayed catastrophic events like floods, thunderstorms.
Arvind Krishna Takes Over As The CEO of IBM — Betting Big On Cloud & AI
Why Use ML For Weather Forecasting?
A big advantage of machine learning is that inference is computationally inexpensive provided an already-trained model, enabling forecasts that are almost immediate and in the native high resolution of the input data.
Weather departments around the globe have comprehensive monitoring capabilities. For example, Doppler radar gauges precipitation in real-time, weather satellites furnish multispectral imaging, ground stations estimate wind and precipitation, etc. All of this is very value and using AI models better forecasting can be made versus traditional techniques. Of course, this would need more training and hiring of experts in the field of data science and machine learning, which currently lags in many institutions.
In the US, remote sensing data obtained by the National Oceanic and Atmospheric Administration (NOAA) is now attaining 100 terabytes per day. NOAA utilises this data to provide the huge weather forecasting engines that operate on supercomputers to give 1- to 10-day global forecasts.
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redpajama_set_name: RedPajamaCommonCrawl


On 3rd June 2014, SingTel in collaboration with Standard Chartered Bank unveiled – Dash. This is a new, ground-breaking mobile money service that revolutionizes banking and mobile commerce, according to the company.
"Dash is centred round the lifestyle needs and habits of a mobile Internet generation who are used to downloading information and content on the go. With Dash, we are offering them an unprecedented experience by allowing cash to be downloaded into their phones as well. But Dash is more than that; it is a suite of mobile money services which integrates three important components - mobile banking, mobile payments and mobile shopping. By bringing together players in the banking, telecommunications and retail sectors, we are able to deliver a differentiating experience for consumers in terms of convenience, ease of use and accessibility," stated SingTel's CEO Group Digital Life, Allen Lew, in a press release. "We are pleased to partner Standard Chartered, as well as the myriad of partners on our platform, to make Dash available to every mobile user," he added.
The company says that this is a first-of-its-kind partnership between a Bank and Telco.
Dash offers innovative solutions that update the way users access, make payments, purchase insurance and save or borrow money.
Dash Easy: This isa bundle of two accounts in one solution – a savings account seamlessly linked to a mobile cash account. Customers can download cash into their mobile phones to pay friends and businesses without the need to access an ATM.
Dash Abroad: This solution is a customisable mobile travel insurance service which offers customers the flexibility to pick and choose coverage options to meet their needs while on the go.
Dash Advance: This is a personal loan facility which customers can apply through their mobile phones, any time.
The user-friendly Dash mobile app for Apple as well as Android smartphones enables users to sign up and access these solutions in a swift manner.
Access your money: Available to subscribers of all local mobile operators, Dash Easy is the first solution of its kind in Singapore that enables customers to download cash from a savings account directly into their mobile phones to pay friends and businesses. Customers no longer have to queue at ATMs to withdraw money.
Goods and Services: Dash has partnered retail industry leaders to create a vibrant, next-generation mobile commerce community. With Dash Easy, customers can make secure payments at more than 20,000 acceptance points islandwide, including retail outlets, convenience stores, food courts and cafes, progressively rolled out in 2014. Customers will also be able to pay for their Comfort, SMRT and Prime taxi fares, without the usual administrative fees. To ensure that payments are secure, seamless and fast, Dash uses a patent-pending technology that integrates the mobile device with the merchants' point of sale systems.
Pay your friends: Dash Easy reinvents the way person-to-person payments are made, through a unique, patent-pending technology that mimicks physical cash transfer. With a swipe, customers can instantly transfer money from their phone to their friends' phones, making it as reassuring as handing over cash itself. Alternatively, transfers can be made to anyone in their contact list.
Save Money: The company says that Dash is the first mobile financial service in Singapore where customers are invited to be co-creators. For example, customers play an active role in determining the interest rate of Dash Easy Savings Account by participating in a unique social media promotion. By including the #needsanupdate hashtag on Facebook, Twitter or Instagram posts, customers can bump up the interest rate on their account to one per cent per annum.
Simple Registration:Customers do not need to visit a bank branch or print copies of their NRIC, as all necessary personal details and documentation can be uploaded through the app. For a limited time, customers will receive a complimentary S$10 welcome bonus, ready to be used, upon the successful sign up and opening of the Dash mobile cash account.
Borrow money and Buy Travel Insurance: With Dash Advance, customers can use the Dash app to apply for personal loans without having to visit a branch or speak to a bank officer. Dash Abroad offers a unique customisable travel insurance plan that gives customers the flexilibity to pick-and-choose coverage options to meet their needs.
Many more updates to come:Their press release states that Dash features will be regularly updated and enhanced, and customers can look forward to more exciting products, features and payment acceptance points in the coming months. They can submit their suggestions on new app features and enhancements via the Dash website, as well as recommend the businesses to be added to the list of supported partners.


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Joey Essex Net Worth 2023: Income, Salary, Career, Bio
2 Joey Essex Net Worth
3 Joey Essex Net Worth Growth
7 Income Sources
8 Assets & Properties
9 Favorite Things
11 Personal Life
Joey Essex is an English TV personality who has a net worth of £6 million. He was born on 29 July 1990 in London. He is well known for his role in the reality show called The Only Way is Essex.
He has also been highlighted for his unique quirky style of clothing and a collection of luxurious expensive accessories. As of 2023, his annual income is around $500,000.
He was also a part of the I'm a Celebrity…Get Me Out of Here. His claim to fame was the TV show titled Educating Joey Essex which was received well by the audience all over. He has also been in highlights for his strings and relationships with various models and actresses.
Today in this post we are going to tell you in detail about Joey Essex, his total net worth, his earnings, salary, and all other business. Looking at his luxurious lifestyle anyone would wonder how much money he must be making. So, the answer to all your questions will be given today in this post. Let's take a look at his net worth.
Joey Essex Net Worth
Full Name: Joey Essex
Net Worth: $6.7 Million
Born: July 29, 1990
Salary: $500,000
Joey Essex Net Worth Growth
Net Worth in 2023 $6.7 Million
Net Worth in 2022 $6 Million
Joey Don Essex was born on 29 July 1990 in London, England. His parents are Donny Essex and Tina Essex. His mother had committed suicide when he was just ten years old.
Although the fact that his mother had committed suicide was hidden from him, his mother's death affected Joey very much. He has a sister called Frankie who is about three years older than him.
He completed his schooling at West Hatch High School. There are not many details available about his college life. He is about 5'5 feet inches tall.
Joey Essex came into the highlight in 2011 after he was featured as a part of 'The Only Way is Essex.' He was seen acting with his cousins in the series. He was then featured in another music video called 'Last Christmas' which was released in the same year.
The video grabbed over one million views on YouTube. He has also contributed to various other series and shows such as Loose Women, Daybreak, All-Star Family fortunes, and The Xtra Factor. Between the years 2012 to 2013, he was seen in shows such as Splash and Celebrity show.
He was then featured in the 13th season of the I'm a Celebrity…Get me Out of Here. He finished the series in the fourth position. He then went on to take part in a reality show called celebs to go dating.
He has also acted in various commercials such as Volvic and Batchelor's. He was also a part of the 'Educating Joey Essex' show that mainly revolved around him and his life.
Joey Essex is someone who loves cars. He recently went on to Instagram to show his followers a brand-new Lamborghini that he recently brought.
Joey Essex's primary source of income is his successful career as a television personality. He has also earned money through various commercials that he is a part of. He is also a part of various other endorsements and brands that fetches him money.
His autobiography titled Being Reem (Reem is a term launched by Joey which means cool and brilliant), was declared one of the best sellers which also is a source of income.
In 2017, he launched his clothing line called the DAFDEA which has been doing well. Additionally, Joey also has his line of perfume which is called My Girls, and a range of aftershave lotions that is called Fusey.
Assets & Properties
Joey Essex has several properties that are mainly situated in London. In 2019, his followers were shown his luxurious mansion at Essex where he currently resides. He also owns a lot of expensive accessories and clothes. In of the shows, he was seen wearing a €1,300 worth of shirt which grabbed a lot of attention.
Favorite Actor Robert Downey Jr.
Favorite Actress Not Know
Favorite Singer Not Know
Favorite App YouTube
Favorite Game N/A
Favorite Food Not Know
Favorite Song Not Know
Favorite Sportsman Neymar
Favorite Movie Don't Know
Favorite Cricketer Rohit Sharma
Favorite Footballer Neymar
Favorite TV Show Not Know
Hobbies Driving
Name Joey Essex
Profession TV personality
Birthplace London
Essex was engaged to fellow TOWIE cast member Sam Faiers but later split up. They reconciled later in 2012. He then proposed to Faiers again in March 2013 and she accepted. However, the couple split up again on-screen in June 2013 following several arguments between the pair. In October 2014 they announced they had split up "for good.
Joey Essex's Tv appearances and commercials help him gain most of his wealth. He also launched his store in London and has his line of perfume and clothing brands. He is also the author of the bestseller Being Reem which is based on his life and experiences.
As of 2023, Joey Essex's net worth is estimated at about €6 million. He is also a bestselling author and an entrepreneur who has launched his line of products that includes clothing and perfumes.
He has been in limelight for his strings and affairs with various co-stars and models. Joey Essex is a popular English TV personality who rose to fame after he was featured in The Only Way is Essex.
He is about 32 years old. The most recent one is rumors of him secretly dating Tia Skillman, who is a shop assistant. The news came in days after he broke up with his ex-partner Brenda Sandos. His annual salary is around $500,000.
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Ranveer Singh Net Worth


Event Planner: Eventful Events, Inc.
Shannon and Mark had a beautiful and elegant summer wedding at The Ahwahnee Hotel. The morning started in the Presidential Suite, where Shannon and her bridesmaids made their wedding day preparations. The ceremony site on The Ahwahnee's wedding lawn with the perfect view of Yosemite Falls. Beautiful decor, floral and gold Chiavari chairs were brought in to accent the gorgeous landscape. Shannon and Mark's ceremony was full of so much joy as they celebrated with family and friends. Shannon beamed as she came down the aisle. The reception was held in the Solarium of The Ahwahnee, which was decorated in navy and gold with lovely custom linens and flowers. The cake topper was a specialty figurine of Shannon and Mark hiking in their wedding clothes. We're sure that on any other day in Yosemite, they would be out hiking or biking the trails. They celebrated into the evening with festivities including dinner and toasts and a live band. Congratulations Shannon and Mark!


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WealthBriefingAsia Singapore Summit, April 2015
Thursday - 16th April 2015
The WealthBriefingAsia Summits are large-scale thought-leadership, education and networking events exclusively for members of the WealthBriefingAsia network.
WealthBriefingAsia events encourage intellectual debate on the challenges and opportunities facing the wealth management industry and are designed to be an optimal use of a wealth manager's precious time. They represent an excellent networking opportunity and attendees also accrue valuable CPD hours.
Attendance is complimentary for members for the WealthBriefingAsia network and its partner organisations, but places are limited.
08:00 - 09:00 Registration and breakfast
09:00 - 10:00 Panel session: Maximising Client Conversion Rates: Multi-Disciplinary Strategies To Get Prospects Over The Line
10:00 - 10:30 Networking and refreshments
10:30 - 11:30 Panel session: Where Next For Wealth Management Technology?
11:35 - 12:35 Panel session: Judging The Best Jurisdiction For Your Client: An IFC Exploration
12:35 - 13:30 Lunch and networking
Date: Thursday 16th April - 2015
Simon Hopkins
Milltrust
Simon Hopkins is a successful entrepreneur who has been a senior figure in the international investment management industry for more than two decades. In 1996 Simon founded Fortune Group, a […]
Simon Hopkins is a successful entrepreneur who has been a senior figure in the international investment management industry for more than two decades. In 1996 Simon founded Fortune Group, a diversified multi asset class advisory firm overseeing US$7 billion, went on to become one of the UK's pre-eminent multi-asset class advisory firms with clients in 24 countries. In 2010, Mr.Hopkins founded Milltrust International focusing exclusively on investment management expertise in emerging markets and specialist real asset solutions driven by the changing demographics of the developing world. The firm delivers the industry's first dedicated emerging markets managed accounts platform to global investors. Simon started his investment career at Warburg Securities (now UBS) and went on to hold senior roles at HSBC and Nomura. He also serves as a director of Swallowcourt Limited, a healthcare business, Homevest Advisors, and Novare Fund Manager, an African asset management firm.
Agnes Chen
Director - Funds, Corporate and Trust, Singapore
Orangefield Group
Agnes has operational and management experience of over 11 years in the financial, trust, Compliance and the Fund administration services sector. She is appointed on board the board of directors […]
Agnes has operational and management experience of over 11 years in the financial, trust, Compliance and the Fund administration services sector. She is appointed on board the board of directors and is a Resident Manager of Orangefield Trust (Singapore) a Trust Company registered with the MAS in Singapore.
Agnes attained qualification as a trust estate practitioner under the Society of Trust and Estate Practitioners (STEP) and is a qualified practitioner in international compliance and anti-money laundering.
Chuck Bokman
Capco Consulting
Chuck Bokman is the lead partner at Capco Consulting's Singapore, office responsible for wealth management clients and their transformation projects. After starting his consulting career in the US with Coopers&Lybrand, […]
Chuck Bokman is the lead partner at Capco Consulting's Singapore, office responsible for wealth management clients and their transformation projects. After starting his consulting career in the US with Coopers&Lybrand, he spent 18 years with PwC, IBM, and then PwC again in Switzerland. Chuck has recently moved to Singapore to lead the launch of Capco's office in the country.
Chuck brings over 20 years consulting experience, focused on wealth management transformation projects ranging from core banking replacement, to digital strategy. He has worked with most of the major players in the private banking and financial services in Switzerland, Europe, and Asia to solve their most pressing problems including regulatory and compliance issues, CRM/portals, target operating models and core banking system implementation.
Damien Piper
Over the past 15 years Damien has worked with leading banks and life insurers in Asia and Europe to find smart technology solutions to improve the customer-facing side of their […]
Over the past 15 years Damien has worked with leading banks and life insurers in Asia and Europe to find smart technology solutions to improve the customer-facing side of their business. He is based in Singapore and covers the major Asia banking centres.
Damien is the Asia regional director for smartKYC. In that capacity Damien works with private banks and institutional divisions in finding automation solutions to the intensive operational customer due diligence and screening processes.
Damien is a strong believer that to be truly useful, technology solutions must be focused on solving business problems other solutions overlook, and alongside this, enable rapid incremental releases of maturity.
Elise Donovan
Director, Asia
BVI Finance
Elise Donovan is the director of the Hong Kong-based BVI House Asia, the representative office for the government of the British Virgin Islands in the Asia Pacific region. BVI House […]
Elise Donovan is the director of the Hong Kong-based BVI House Asia, the representative office for the government of the British Virgin Islands in the Asia Pacific region. BVI House Asia was established in 2013 to help manage the 25-year+ relationship that the BVI has with the Asia Pacific region, particularly in the financial services industry. Prior to this appointment, Elise was the executive director of the BVI International Finance Centre, which is responsible for marketing, promotion and reputational management of the BVI's financial services industry. Elise has a wealth of experience in international affairs, economic development and public relations, and has also worked in New York, Washington DC, Nigeria and South Africa. She has written numerous articles about the significant role of the BVI as a world-class international finance centre in the global financial system.
François Monnet
Managing Director, Chief Operating Officer, Private Banking Asia Pacific
Dr. François Monnet has been the chief operating officer for private banking Asia Pacific for Credit Suisse since April 2012. Before that, he was the head of ultra-high net worth […]
Dr. François Monnet has been the chief operating officer for private banking Asia Pacific for Credit Suisse since April 2012. Before that, he was the head of ultra-high net worth for private banking Southeast Asia, Australia and Japan.
François joined Credit Suisse in 2007 as head of private banking Southeast Asia and Australasia. Prior to that, he headed the offshore private client business segment in Asia Pacific at UBS, with an additional focus on the Singapore domestic market. He also worked for UBS in Zurich in mergers and acquisitions. François has substantial experience in business development in the financial and consumer industries across Asia Pacific and Europe, with UBS and Eastman Kodak Corporation.
Herdin Syafari
Rawlinson & Hunter
Herdin has more than 16 years experience in Indonesian and International tax consultancy having previously worked for one of the "Big 4" accounting firms for 11 years. Serving multinational clients […]
Herdin has more than 16 years experience in Indonesian and International tax consultancy having previously worked for one of the "Big 4" accounting firms for 11 years. Serving multinational clients from various industries, Herdin also has 5 years of experience working as Head of International Tax Department in Indonesia's largest public energy company.
In addition, Herdin is a certified Indonesian Customs and Trade consultant, with a Customs Certification from the Indonesian Directorate bof Customs and Excise. He has been involved in various customs projects from master list facility application, due diligence, audits and appeals assistance in the tax and customs courts.
Herdin obtained his first degree in Economic and Accounting in Indonesia and a Masters Degree in Business Administration (MBA) from the University of Bath, United Kingdom. He is a Certified Indonesian Tax Consultant, Certified Indonesian Customs Expert and holds a License of Tax Power of Attorney for Tax and Customs Appeal in the Indonesian Tax Courts.
Kimmis Pun
President and Certified Financial Planner
Financial Planning Association of Singapore
Kimmis Pun has three decades of management experience in corporate finance, syndication, global investment and advisory fund management. Equipped with professional investment and financial planning qualifications from the UK, US […]
Kimmis Pun has three decades of management experience in corporate finance, syndication, global investment and advisory fund management. Equipped with professional investment and financial planning qualifications from the UK, US and Singapore, she is the managing director of BNP Paribas looking after the China market. With a passion to contribute and share, she frequently speaks at seminars, gives lectures at universities and academies as well as being featured in financial magazines and newspapers. Besides her business acumen and self-initiatives in her career advancement, she has made significant contributions to society through charitable movements.
Laurent Bertrand
Head of Business Insights and Client Information
UBS Wealth Management
Laurent Bertrand is executive director and head of business insights and client information for UBS Wealth Management APAC, based in Singapore. In this role he is responsible for the business […]
Laurent Bertrand is executive director and head of business insights and client information for UBS Wealth Management APAC, based in Singapore. In this role he is responsible for the business transformation of private banking and wealth management for the bank in the APAC region. He leads the development and management of analytic and big data and driving strategic change initiative related to front-office effectiveness, risk and regulations.
Prior to joining UBS, Laurent was an external consultant for operational risk projects at Societe Generale Private Bank's Singapore branch. He also helped to establish Dresdner Bank's first wealth management and private bank offering in Singapore, as well as serving as its chief operation office.
Mandeep Nalwa
Taurus Wealth Advisors
Mandeep Nalwa is a wealth advisor with over 20 years of financial services experience. He has managed high net worth client relationships across Asia with leading private banks like HSBC, […]
Mandeep Nalwa is a wealth advisor with over 20 years of financial services experience. He has managed high net worth client relationships across Asia with leading private banks like HSBC, Merrill Lynch and Citi. He has been the primary advisor on large client portfolios and has been responsible for suitable development and implementation of customised investment advice and portfolio management. Prior to setting up Taurus, Mandeep had spent most of his career with various private banks in the Asia-Pacific region with specific exposure to equities, fixed income, currencies, derivatives and managed assets.
As the chief executive officer of Taurus Wealth Advisors in Singapore, advising HNWIs within the framework of a multi-family office, Mandeep has successfully built up a team of experienced financial advisors, providing unbiased investment advice to the wealthy with total assets under advice currently in excess of S$1 billion.
Reto Merazzi
General Manager, APAC Region
As general manager for Appway across the APAC region, Hong Kong-based Reto Merazzi has more than 20 years' experience in the international banking sector. Reto's career began in his native […]
As general manager for Appway across the APAC region, Hong Kong-based Reto Merazzi has more than 20 years' experience in the international banking sector. Reto's career began in his native Switzerland at Zuercher Kantonalbank until he moved to Credit Suisse where he worked in securities lending and borrowing. He joined UBS in 2000 and after assignments in Singapore and New York was promoted to head of strategic portfolio management APAC in wealth management IT. Reto moved to Hong Kong with UBS in 2010 and joined Appway three years later.
A specialist in business technology, Reto has defined strategies from small local roll-outs to substantial global implementations.
Richard Grasby
Richard Grasby is a Partner in Appleby's Hong Kong office, leading the Private Client, Trusts and Family Office practice. Richard advises trustees, ultra-high net worth individuals, private trust companies and […]
Richard Grasby is a Partner in Appleby's Hong Kong office, leading the Private Client, Trusts and Family Office practice.
Richard advises trustees, ultra-high net worth individuals, private trust companies and family offices on the establishment, restructuring and administration of trusts, including special trusts i.e. BVI VISTA, Cayman STAR and Employee Benefit Trusts. He regularly assists in estate administration, succession planning and family governance. Private clients and family offices instruct Richard to advise on the use of corporate vehicles for asset holding and succession planning purposes. Richard is an expert in regulatory law including AML, AEOI, economic substance and licensing and risk management for trust companies. He also advises on collective investment funds, particularly unit trusts and private label funds.
Richard has acted for many of the world's leading trust companies, financial institutions, wealthy individuals and related structures. He has experience with dealing with clients and advisors across the globe.
Richard has over 20 years' post qualification experience with the majority spent in offshore firms. Richard has lived and worked in Jersey, London, the Cayman Islands and (since 2009) Hong Kong. He is admitted as a solicitor in England and Wales and the British Virgin Islands and is a Registered Foreign Lawyer in Hong Kong. He has also been admitted as an Attorney in the Cayman Islands.
Richard is an active member of STEP. He has been on the local executive committee since 2012 and is a former chair. He is on the global steering committees for the Business Families and International Client Special Interest Groups. He is a member of the Academic Community.
Richard is an elected Academician of the International Academy of Estate and Trust Law (the only such offshore practitioner in APAC). He is also a Certified Anti Money Laundering Specialist.
Richard is a lecturer on trusts and family offices for the Hong Kong Securities and Investment Institute and for the Hong Kong University of Science and Technology.
He is a member of the Hong Kong Trustee Association, the Family Firm Institute the International Bar Association and the Investment Migration Council.
Richard is an active speaker at events across the world and a writer for many journals.
Simon Cornwell
Sales and Marketing Director
Simon is one of the three founding directors of Vermilion Software and is responsible for the development of the global marketing and sales strategy for Vermilion. Simon has over 20 […]
Simon is one of the three founding directors of Vermilion Software and is responsible for the development of the global marketing and sales strategy for Vermilion. Simon has over 20 years' experience in application sales and infrastructure both in the City of London and globally. He is based in Singapore.
Steven Seow
Singapore Consultancy
Steven Seow is the founder and executive director of Singapore Consultancy. He has more than 16 years of working experience in banking and consulting. Prior to running Singapore Consultancy, he […]
Steven Seow is the founder and executive director of Singapore Consultancy. He has more than 16 years of working experience in banking and consulting. Prior to running Singapore Consultancy, he was the Asia head of wealth management for Mercer (2013-2017) and a director in EY Advisory (2008-2013). Over the course of his career, he has also worked in Citi Private Bank, IBM, PwC Consulting and Odyssey.
This event has already taken place.


The whole aroma is wrapped in a warm and inviting bourbon spice. Inside that wrapper is caramel with some honey and graham cracker. Under these lie some hints of corn, vanilla and a touch of tropical fruit and a very light rye. Much lighter rye notes in the nose than any of the small batch or single barrel bottles I've had.
Here's where the Yellow label really comes into it's own. Upfront we have a lot of warm caramel, vanilla and delightful bourbon spice. Corn, honey, rye and malt sit side by side with some light fruit flavors which are less tropical and more orchard on the palate. A bit of clove and a slight yeastiness rounds out the earthy undertones.
The extremely short finish is pleasant with caramel and sweet toffee fading to soft oak and corn.


text:
Coveo Leads Gartner Magic Quadrant In Enterprise Search
Coveo Named Visionary In Gartner Magic Quadrant For Enterprise Search
And We Agree.
Fishtank would like to extend our congratulations to Coveo regarding Gartner's latest Magic Quadrant on Enterprise Search.
Coveo has been found to be the leader in completeness of vision. Notably, it's "visionary" value along the x-axis is double its nearest competitor.
Fishtank echos Gartner's sentiments that Coveo Enterprise Search is a visionary product. Coveo's context and relevance technology coupled with its platform agnostic API transcend traditional search engines, creating a new paradigm for discovering data in the enterprise.
If you're interested in enterprise search, I would encourage you to read Gartner's full report.
However, if you're interested in a next-generation enterprise search, you may want to skip directly to Coveo.


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Q: Using Asp.NET Identity with custom user manager/database I would like to use some parts of the Identity system of Asp.NET to access a custom database, but not all of the parts.
The database portion wasn't too difficult, but I am trying to find out how to write code to put to work some of the Identity methods into my custom implementation. For example one of the differing items is to not use the UserManager password hash, but instead use some other 3rd party password hash function. Some of the things I'd like to take advantage of is the cookie authentication, password validator fields, etc.
So, first thing I tried to do is look at what the standard CreateAsync method does, and it takes me to a blank line looking something like this:
[AsyncStateMachine(typeof(UserManager<>.<CreateAsync>d__73))]
public virtual Task<IdentityResult> CreateAsync(TUser user, string password);

How can I make custom create-async and password-verification functions?
Oh, also by 'custom database' I mean, I do not want to use the tables that come with Identity, no Roles, Claims, just my own Users table is all.

A: I recently did this but there's too much code to post it all here as an answer unfortunately.
For CreateAsync you need to make a custom userstore class that implements IUserStore<your custom user>, IUserPasswordStore<your custom user>
    then you need to implement the CreateAsync method:
async Task<IdentityResult> IUserStore<your custom user>.CreateAsync(your custom user user, CancellationToken cancellationToken)
        {

            IdentityResult result;
            var tsk = Task.Factory.StartNew(() => result = someDataAccessClass.SomeSaveUserToDatabaseFUnction(user));

            return await tsk;
        }

You can implement the data class and save user function however you want at that point.
The password verification is a little more complex depending on what you do.
You'll have to create a custom SignInManager that inherits from the the regular SignInManager. Then just override the PasswordSignInAsync method with whatever you're doing security-wise. Also note that you'll need to implement some of the other functions on the UserManager like find user async and stuff like that.
Also note that for the Identity Pipeline to fill in the missing pieces you need to do services.AddIdentity().AddUserStore().AddSignInManger (and all the other classes you customize) in your startup.cs configureservices() method and then throw app.UseIDentity() into your configure method too.

redpajama_set_name: RedPajamaStackExchange


JAX-WS (+ WSS4J for the security) is a quite common solution used by enterprises but JAX-WS is quite slow by design (pipeline, xml serialization, depending on implementation a lot of reflection or bytecode generation in some cases…) and the question to compare it to a simpler protocol comes pretty quickly when you held both client and server sides.
This article aims to show how JAX-WS could be replaced by EJBd protocol on TomEE (>= 1.6.0 – currently in snapshot when writing these lines).
This entry was posted in OpenEJB, TomEE and tagged ejbd, jaxws, openejb, tomee on 11/07/2013 by rmannibucau.
JAX-RS endpoint configuration was not possible (or not easy at all) in last TomEE release. The brand new one makes it possible.
This entry was posted in TomEE and tagged configuration, jaxrs, jaxws, tomee on 04/10/2012 by rmannibucau.


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Home » A Successful Lifeline for Natomas Students Is Feeling the Strain
A Successful Lifeline for Natomas Students Is Feeling the Strain
Today, we have a dispatch from the U.C. Berkeley Graduate School of Journalism. It was written by Erin Chessin and Brett Marsh:
The Natomas Unified School District, a diverse, low-income community on the northern outskirts of Sacramento, is celebrated for its pioneering mental health program. The program, created after a student's suicide in 2014, dispatches rapid response teams to offer students help whenever school staff or special monitoring software on school-supplied computers detect warning signs of suicide or emotional distress.
It was so successful that the California School Boards Association gave the program a Golden Bell Award in 2016, citing it as an innovative model for others to emulate.
But now, after a year of school closures, and with the pandemic still far from extinguished throughout much of the state, including in and around Sacramento, the Natomas mental health program is itself under enormous stress, school officials say.
Carol Swanson, the district's associate superintendent, said that the accumulating strain of endless Zoom classes and the isolation of being stuck at home had produced a "staggering" onslaught of urgent alerts about students struggling with mental health problems, and that demand for the district's mental health services had soared.
In a typical school year, Natomas provides mental health support to about 1,200 students. But in the last year, more than 3,900 of the district's roughly 15,000 students have needed help, and school officials suspect the actual number is much higher.
[What to know about California's plan for reopening schools.]
"The hard part is that we don't see our kids every day,'' Shea Borges, executive director of the district, said. "As a former teacher and principal, you could walk on my campus and I could take a look at you for one second and know that you're having a bad day."
Some Natomas students have little reprieve from already stressful home lives. Nearly three-quarters of the students qualify for free or reduced-price lunches, and the pandemic has added to longstanding stressors at home, be it job insecurity or difficulties paying for groceries.
"Young people at Natomas and across Sacramento have been challenged beyond what most people in their life are challenged with," said Michael Lynch, co-founder of Improve Your Tomorrow, a nonprofit organization that provides mentorship for students at Natomas High and other schools in the Sacramento area. "Loneliness exacerbates trauma, and trauma breeds mental health challenges.''
To get a better sense of how their students were coping, the Natomas school district's leaders conducted a voluntary mental health survey of the student body in October and November. With about two-thirds of the students participating, the district identified an additional 460 students who needed extra attention from mental health staff members.
Seventeen school psychologists work in the district's schools. But instead of meeting students in an office or on campus walks, the psychologists have fallen into a steady but exhausting rhythm of holding individual and group counseling sessions over Zoom. "It's really emotionally difficult for everybody," Ms. Swanson said. "And that's one of the things I want to stress, is we often forget about our own needs when we're reacting to situations."
The Natomas mental health system also uses a computer program called GoGuardian to monitor what students are typing on school-supplied computers. If, for example, a student does a Google search for "painless ways to commit suicide" or the phone number of a suicide hotline, an alert goes out to a team of school officials, including the school principal, a district supervisor and Earl Pavao, the head of student services and the one most likely to respond. There is also a website where students, teachers and family members can anonymously notify the district to check in on a student.
"Any time a referral comes, there's a quick flurry of texts," Mr. Pavao said. "I'm like a fireman who jumps down the pole."
That often means racing to the home of a troubled teenager if counselors can't get through to a student or their parents or guardian. Yet Stan Collins, a suicide prevention specialist based in Sacramento, said the full psychological fallout on students wouldn't even be felt until after the pandemic.
"We have felt the earthquake, but the tsunami has not yet reached our shores," Mr. Collins said. "It's vital that we stay vigilant."
With the return to in-person instruction this month, district officials are hopeful students will be less stressed.
"Every step of being back in-person absolutely plays to the upside of student health," Mr. Pavao said. "Just being in a place at school again is a pretty therapeutic adjustment from being isolated."
Oscar Chavez was a senior at Natomas High when the outbreak caused nationwide school closures. The son of first-generation Mexican immigrants, Mr. Chavez, now 18, said the new stresses brought by the coronavirus intensified the "dark thoughts'' he has wrestled with for years.
During his junior year, he sought help after a school counselor urged him to consider getting therapy — a step, he said, that led to a diagnosis of depression. The therapist he had started seeing, he said, helped him cope with the anxieties the pandemic brought to his senior year. "I'm glad I had that sort of safety net," said Mr. Chavez, who graduated last June.
"A teacher being able to provide support to their students, whether it's just listening, is very important," he said. "I'm glad I got to experience that."
If you are having thoughts of suicide, call the National Suicide Prevention Lifeline at 1-800-273-8255 (TALK) or go to SpeakingOfSuicide.com/resources for a list of additional resources.
Zachary Stauffer contributed reporting.
(This article is part of the California Today newsletter. Sign up to get it delivered to your inbox.)
Here's what else to know today
The San Francisco school board is divided over whether one of its members should resign in the wake of racist tweets about Asian-Americans. [San Francisco Chronicle]
After years of debate, California last week approved an ethnic studies curriculum for K-12 students. [CNN]
After remaining shuttered for six months, Regal Cinemas will reopen its theaters in April. [New York Times]
In a blow to cinemas, Walt Disney Studios pushed back the release dates of six movies, including the hotly anticipated Marvel superhero film "Black Widow." [New York Times]
"The Ellen DeGeneres Show" has lost more than a million viewers, a decline of about 43 percent, according to the research firm Nielsen. [New York Times]
Prince Harry began a new job at a San Francisco tech company. [San Francisco Chronicle]
"Did I ever tell you about the time I played Elgin Baylor?" The Times sports columnist Kurt Streeter recalls how the time his father faced the Lakers' great on the court became family lore. [New York Times]
Mr. Baylor died this week. Read about his storied life in this obituary.
California Today goes live at 6:30 a.m. Pacific time weekdays. Tell us what you want to see: [email protected]. Were you forwarded this email? Sign up for California Today here and read every edition online here.
Jill Cowan grew up in Orange County, graduated from U.C. Berkeley and has reported all over the state, including the Bay Area, Bakersfield and Los Angeles — but she always wants to see more. Follow along here or on Twitter.
California Today is edited by Julie Bloom, who grew up in Los Angeles and graduated from U.C. Berkeley.
Tags: Feeling lifeline Natomas Strain Students Successful
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Tim focuses on providing comprehensive assurance and management consulting services to a diverse client base in the real estate, manufacturing, construction, not-for-profit, aviation and governmental industry sectors. With more than 20 years of experience, he currently serves clients as part of the firm's construction and manufacturing and distribution specialty groups. Tim serves as the Office Leader for Elliott Davis' Charleston office.


But it wasn't only Mixon who came up short. Giovani Bernard had a pair of 25-yard runs as his best efforts. The Bengals' running game finished last in the league with those 25-yard runs as their longest from scrimmage.
The Bengals' running game was one of the worst in their history. In four games, the running backs failed to produce a run of at least 10 yards. Andy Dalton had a 25-yard scramble in one game that matched the biggest gain on the ground all season.
"I'm glad it's a new year," Mixon said. "We definitely are going to make that up, for sure. I can tell you that now."
The Bengals were so enamored of his ability to catch passes as well as break long runs that they took him in the second round of the draft, knowing they'd get a public backlash. He was suspended for his freshman season at Oklahoma for punching a woman in the face.
Unhappy with the results, Mixon changed his diet in the offseason and lost 12 pounds, getting back to his playing weight at Oklahoma. He's looked good in training camp at 216 pounds, with coach Marvin Lewis singling him out for praise on Wednesday.
"I've been excited about Joe Mixon and what he's doing," Lewis said.
"He knows we both can do anything," Bernard said. "It's not the situation of a first-down back or a second-down back or third-down, it's none of that. It's just plug-and-play."
"There's been a lot of urgency within the offensive line to get things moving, and it shows," Bernard said.
Gio's donation: Bernard helped his future mother-in-law donate a van to an injured Marine veteran on Tuesday, the team's day off. Bernard drove the van — owned by his future mother-in-law — during his rookie season.
"It was obviously hard to see it go, but it was fun to see it go to a family that needs it," Bernard said.


Sherlock fans, this is the opportunity of a lifetime.
One lucky competition winner will get the chance to sit down for breakfast with Benedict Cumberbatch and the cast of Sherlock, including Andrew Scott, Rupert Graves and Mark Gatiss.
Yes, you could actually be having an Eggs Benedict with Benedict Cumberbatch. But it gets better.
Breakfast with seven Doctors – live tweeted!
The grub is going to be served up by Mrs Hudson herself as Una Stubbs gets her pinny on in the kitchen. Steven Moffat will also be there and you will have a tour of filming locations from the hit BBC1 drama by Louise Brealey – aka Molly Hooper.
Oh, and did we forget to mention that you'll be sitting down for said breakfast at the infamous Speedy's cafe – the one located right next door to Sherlock's abode?
Emma Freud announced the news as part of her fundraising campaign for Red Nose Day in the US.
In a video posted online, Cumberbatch says: "The whole thing should be rather enjoyable. And when I say rather enjoyable, I mean the best f**king breakfast of our lives!" as he promises "eggs and s**t".
We'll just take the eggs, thanks.
How can you enter this incredibly amazing competition? Well all you need to do is go to omaze.com/sherlock and follow the instructions, and all money raised will go to Comic Relief in the US.
Meanwhile, Cumberbatch will next be seen (sadly not in person) in new TV series Patrick Melrose. Anyone can watch the first episode for free here on RadioTimes.com. Click here for more details.


On Friday morning around 7, Mike Owens' phone rang. On the other end was Debbie Janssen, the wife of veteran musher Scott Janssen.
There was trouble on the trail.
"Predominantly Jim Lanier was in a life-threatening situation and that [he] needed to be extracted from the trail. He was hypothermic," said Owens an, Iditarod Trail Committee board member.
Owens, a Nome resident and finisher of the race back in 1987 and 1990, mobilized a crew on snow machines and set off for the trail.
Thankfully, Jessie Royer, who'd already completed the race, and Daniel Strang, were already in Safety and were able to reach Lanier and Janssen, bringing them back by snowmachine. Lanier veered off course toward the open water of the Bering Sea, then turned around, only to get stuck on driftwood. Thankfully, Janssen came by, saw him and stayed.
After being found by Royer and Strang, the Lanier and Owens parties connected. Lanier made it clear what his priority was: his dogs.
Owens reassured the 77-year-old veteran.
But now Owens' had to find the dogs. As he and his team entered the blowhole, they place lived up to its name and reputation. It's known for producing hurricane-force winds and whiteout conditions.
"There were times we were down stake-to-stake," he's said. "I mean, that's all you could see. You'd have to stop and look, and the wind would let a little to where you could see just the top of the stake. And you would go to the stake and stop and look and wait. And there [were] times you didn't know if you were on a side hill, flat level-- snow coming at you from all directions."
They were also dangerously close to the sea ice and open water.
"That's my greatest fear," said Owens, "To one day lose a musher and team off that ice."
They avoided that pitfall and ultimately reached the dogs. They were in good condition.
But what to do with 24 dogs? Tie them together using Lanier's sled and get them home. After a stop in Safety-- a good omen-- they snacked the dogs and headed out. Eventually, they all reached Nome.
"What I'm so thankful for is I have two mushers that I have a lot of respect for that are healthy and doing well recovering. And I have 24 four-footed friends that they, too, have bounced back, are happy and they'll be ready to run again."
And everyone is thankful for Mike Owens--in case he needs to run again.


text:
Movie File: Billy Bob Thornton, Andy Milonakis, Nicole Eggert, Steve Carell & More
'Bad News' star to work with eccentric Polish brothers on 'Astronaut' movie.
Larry Carroll 08/22/2005
Keeping true to his indie roots, "Bad News Bears" star Billy Bob Thornton will be working with notoriously eccentric filmmakers the Polish brothers in their upcoming film "The Astronaut Farmer." Produced by Warner Independent Pictures, the movie will tell the story of an astronaut (Thornton) who leaves NASA to concentrate on saving his family farm. When the man's dream of traveling through space causes him to build his own rocket, the government attempts to shut him down through a series of darkly comedic methods. Identical twins Mark and Michael Polish, who've released the quirky films "Jackpot" and "Northfork" since debuting on both sides of the camera playing conjoined twins in 1999's "Twin Falls Idaho," wrote "Astronaut" together. The film is due to begin shooting in New Mexico early next month and is currently searching for a lead actress. ... It seems like we can all stop waiting for the upcoming Ryan Reynolds/Justin Long movie. Coming on the heels of last week's announcement that the food-service comedy was pushed to a spring 2006 release, Lions Gate has now boomeranged the film back to an October 7 debut. "Waiting ...," which tells the story of prank-loving employees at a family restaurant called Shenanigan's, also stars Anna Faris, Andy Milonakis and Dane Cook. ...
National Lampoon is making a new movie, and one can only wonder if the irony was lost on the army of actors who auditioned for it. "Cattle Call" began production on August 15 in Los Angeles, starring Thomas Ian Nicholas ("American Pie"), Jenny Mollen (TV's "Angel"), Diedrich Bader ("Napoleon Dynamite") and former "Baywatch" beauty Nicole Eggert. The film tells the story of a group of guys who invent a fake casting agency to meet women, then scramble to shoot a movie or risk being exposed as frauds. Promising a "twisted, out-of-left-field surprise ending," the Lampoon group claims that the film will follow in the footsteps of recent romps including "Van Wilder" and "Gold Diggers." "Cattle" hopes to stampede into theaters nationwide next spring. ... No, it doesn't have anything to do with Balki Bartokomous or cousin Larry, but Bruce Willis has been cast in "Perfect Stranger," a psychological thriller whose title only sounds like the goofy '80s sitcom. The film, set in the mysterious world of the Internet, will have Willis as a murder suspect being investigated online (and offline) by an undercover female officer. "Glengarry Glen Ross" helmer James Foley will be directing the film, with Halle Berry playing the undercover cop. Willis, Berry and Foley expect to begin their "Perfect Stranger" dance of joy when the film starts production in early 2006. ...
Now that he's lost his virginity, Steve Carell is ready to lay back, light up a cigarette and bask in the afterglow. The "40-Year-Old Virgin" star, who is suddenly a hot commodity after years of supporting roles in films like "Bruce Almighty" and "Anchorman," is attached to star in the tentatively titled "High T," a comedy from the high-concept writer of "50 First Dates." The funnyman will play a guy whose behavior veers off in wild directions after he begins taking testosterone shots that drastically alter his hormone levels. ... Dwayne "The Rock" Johnson urges patience for the diehard fans who keep asking him about the upcoming movie "Spy Hunter," based on the hit video game. The action star promises that the movie will be made, and that the right people are working on developing it. " 'Spy Hunter' is going great," the thick-armed thespian insisted. "We've got Stuart Beattie who's writing it right now, who wrote 'Collateral' as well as 'Pirates of the Caribbean,' so he's a great writer, he's got a great take on it. 'Spy Hunter' is one of those movies that we announced almost two years ago and everybody who I run into is like, 'Where's 'Spy Hunter?' It's one of those movies that you cannot get wrong. That's why it's so important that the writing is right, the feel, the tone is right. You see the car, you see [my character] Alec Sects. So it's going to be the real deal once it's done." The star also said no one else had been cast yet: "Not yet — just myself and the car, the Interceptor. And that thing is bad. We've already seen some early drawings of it and early renditions of it on video. It just jumps off a cliff, turns into a boat, then into a motorcycle when it comes back on land. It's badass." ...
From aliens and hoodoo to fairytale characters, it seems director Iain Softley has a thing for magic, witchcraft and make-believe. The man behind "K-PAX" and this month's "The Skeleton Key" has been working on his next project in the south of France, called "Trap for Cinderella." Based on the book by Sébastien Japrisot ("A Very Long Engagement"), Softley describes the as-yet-uncast erotic thriller as concerning "a girl [who] wakes up from an accident. She's been badly burned. She's had face surgery [and has] no memory of what's happened." As if that's not traumatic enough, afterward "she finds out that there was another girl in the house who was burnt to death and that girl was trying to switch identities with her." And since no Softley film is complete without a twist, he added "Or was she?" ... "I play a bad guy, and I play him very well," veteran actor Eric Roberts said with a smile as he discussed his role in the upcoming based-on-a-video-game movie "DOA: Dead or Alive." The film, due in theaters in the spring, casts him as a supervillain alongside stars Devon Aoki, Jaime Pressly and Kevin Nash. "I play a man who owns a private island; he's a great martial artist. He owns a private island, and he invites all the great martial artists of the world to come to this island and fight. But what he does is, they're injected with [devices] in their blood system, so he can register all their moves, and he downloads all their moves, and then he can predict what they're going to do as they think it. And he can kick their hiney," he laughed. "Uh-uh ... It's 'Enter the Dragon' meets 'Charlie's Angels.' " ...
Paul Giamatti has taken on Howard Stern ("Private Parts"), a nasty spit bowl ("Sideways") and, most terrifying of all, Frankie Muniz ("Big Fat Liar"). Now the wide-eyed character actor is targeting a different audience with "Shoot 'Em Up," a hardcore action film that would have him playing the villain opposite Clive Owen's hero. Both Giamatti and Italian temptress Monica Bellucci ("The Passion of the Christ") are in negotiations to join the movie, which New Line Cinema is hoping to shoot in January. "Shoot" tells the story of a mysterious man known as Mr. Smith (Owen) who helps deliver a baby during a shootout. Suddenly faced with an unexpected sense of paternal love, Smith must protect the baby from an army of gunmen working for Giamatti's character. Bellucci, if signed, would play Owen's love interest. ... Twenty-five years later, "Joliet" Jake and his brother Elwood are getting the band back together. In celebration of the quarter-century anniversary of the classic Dan Aykroyd-John Belushi film "The Blues Brothers," Universal Pictures will be re-releasing it on the big screen in more than 80 theaters across the U.S. Making the event even more exciting, screenings on Monday, August 29, will be preceded by a live satellite Q&A with writer/director John Landis and Aykroyd himself. Those with a full tank of gas and half a pack of cigarettes can follow up the screenings with a drive to their local video stores later this month, where they can purchase the new 25th Anniversary DVD complete with two versions of the film and tons of bonus material. Orange whips for everybody!
Visit Movies on MTV.com for more from Hollywood, including news, interviews, trailers and more.
The Bad News Bears
The 40-Year-Old Virgin


text:
Q: Gurobi: Prod() in addConstrs() When I set up the constraint, the code is
m.addConstr(binary_var.prod(cost_con) <= budget[k])

binary_var is the variable name, cost_con is the coefficients of the variables. The constraint is a linear expression, like
cost_con[0]*binary_var[0]+cost_con[1]*binary_var[1]+cost_con[2]*binary_var[2]+....

Here is the problem.
Since the number of variables is very large, nearly 5000. So the code binary_var.prod(cost_con) costs a lot of time. Could you please tell me if you have some better solutions to decrease the running time?
Thanks


guess who was also at the lady gaga show. Sources say that Ram Charan was invited by Sam Branson (son of UK based business tycoon Richard Branson of virgin racing)to support the virgin racing team. He along with Sachin Duggal ( Nivio a cloud computing firm), Roma Khanna president of MGM digital out of LA and other music producers from the US were at their table. Sources say that they all enjoyed the fabulous performance of Lady Gaga and had a great time till the very end.


text:
Medellín Kolumbia második legnépesebb városa. Az ország északnyugati részén terül el.

Földrajz
Medellín Észak-Kolumbiában, Valle de Aburrában fekszik. A város 8 településből áll. Híres orchideáiról, virágairól, beceneve: Capital de las Flores (A virágok fővárosa).

Éghajlat
Az évi középhőmérséklet 24 °C. Nyáron nem megy 30 °C fölé és télen nem megy 16 °C alá.

Történelem
A város mai területére először 1541-ben jutott el Jeronimo Luis Tejelo spanyol felfedező, de települést csak 1616. március 2-án alapított itt Francisco de Herrera Campuzano spanyol hódító Campuzano San Lorenzo de Aburra név alatt. 1675-ben a település nevét megváltoztatták Villa de Nuestra Señora de la Candelaria de Medellín-re. 13 évvel később Antioquia megye központja lett.

Kormányzat
A város polgármesterét négyéves időszakokra választják meg.

Gazdaság
Medellín gazdasága jelenleg az egyik legnagyobb Kolumbiában. Sok nemzetközi vállalat központja. Főbb gazdasági termékek az acél, textíliák, élelmiszerek, valamint a vegyipari termékek, gyógyszerek és a kőolajtermékek.

Oktatás
A városban több mint 30 egyetem működik, melyek közül a jelentősebbek: Universidad de Antioquia (1803), Universidad Nacional y Politecnico Jaime Isaza Cadavid, Universidad EAFIT magánegyetem (1966), Universidad de Medellín (1950), Universidad Pontificia Bolivariana (1936). Ezenkívül több szakiskola, valamint magániskola működik a városban.

Közlekedés
Medellínben 1995-ben és 1996-ban egy-egy magasvasútvonal, 2004-től kezdődően pedig számos, ezekhez kapcsolódó tömegközlekedési drótkötélpályásfelvonó-vonal létesült.

Légi közlekedés
A város légiközlekedését a José María Córdova nemzetközi repülőtér szolgálja ki, ahonnan a világ több pontjára indulnak járatok (New York, Caracas, Quito). A város másik repülőteréről, az Olaya Herrera nemzetközi repülőtérről főleg belföldi járatok indulnak.

Szárazföldi közlekedés
A városi tömegközlekedést buszok, taxik, valamint a városi magasvasúti és kötélvontatású személyszállító vasúti rendszer, a Metro de Medellín alkotja.

Kultúra
A városban rendezik meg évente a Virágfesztivált (Feria de Flores).

Karácsonykor rendezik meg a Fényfesztivált. A folyóra kis mécseseket tesznek ilyenkor és a fény bevilágítja a várost.

Sport
1995 óta rendeznek a városban félmaratont. Medellínben két jelentős labdarúgócsapat működik (az Atlético Nacional és az Independiente Medellín), amelyek a szövetségi ligában játszanak.

Testvértelepülések
  Barcelona, Spanyolország
  Bilbao, Spanyolország
  Buenos Aires, Argentína
  Fort Lauderdale, Amerikai Egyesült Államok
  Milánó, Olaszország
  Monterrey, Mexikó

Jegyzetek

További információk

 Alcaldia de Medellín - hivatalos oldal

Egyetemek
 Universidad de Antioquia
 Universidad EAFIT
 Universidad de Medellín
 Universidad Nacional de Colombia

Újságok
 El Colombiano
 El Mundo

Antioquia megye települései

redpajama_set_name: RedPajamaWikipedia


Day Five of "The Breakfast Club", with the amazing Madeleine Shaw, Nutrition Coach. Visit her website for more delicious recipes. This recipe is by Me or "Make & Bake from Scratch". It is a beautiful recipe for breakfast or could be savoured as a dessert.
Chia Pots are a great way to put a spring in your step in the morning time. They are packed with protein, fibre and omega 3 fatty acids. By adding a tablespoon of chia seeds you can increase your protein intake on a daily basis. Chia seeds contain soluble and insoluble fiber which is great for digestion and regularity. Chia pots have a rice pudding consistency. You will need to leave them in fridge overnight or at least 6 hours. You can add your toppings of your choice when they have set.
Add all the ingredients to your pots and stir the mixture with a small spoon until combined. Pop in the fridge overnight.
Next morning give it a little stir before devouring, sprinkle with your favourite toppings.


text:
using lanterna.graphics;

using System;
using System.Runtime.CompilerServices;

namespace lanterna.gui2 {

/**
 * Default window decoration renderer that is used unless overridden with another decoration renderer. The windows are
 * drawn using a bevel colored line and the window title in the top-left corner, very similar to ordinary titled
 * borders.
 *
 * @author Martin
 */
    class DefaultWindowDecorationRenderer : WindowDecorationRenderer {
//
        public virtual TextGUIGraphics draw(TextGUI textGUI, TextGUIGraphics graphics, Window window) {
            string title = window.getTitle();
            if (title == null) {
                title = "";
            }

            ThemeDefinition themeDefinition = graphics.getThemeDefinition(typeof(DefaultWindowDecorationRenderer));
        	char horizontalLine = themeDefinition.getCharacter("HORIZONTAL_LINE", Symbols.SINGLE_LINE_HORIZONTAL);
        	char verticalLine = themeDefinition.getCharacter("VERTICAL_LINE", Symbols.SINGLE_LINE_VERTICAL);
        	char bottomLeftCorner = themeDefinition.getCharacter("BOTTOM_LEFT_CORNER", Symbols.SINGLE_LINE_BOTTOM_LEFT_CORNER);
        	char topLeftCorner = themeDefinition.getCharacter("TOP_LEFT_CORNER", Symbols.SINGLE_LINE_TOP_LEFT_CORNER);
        	char bottomRightCorner = themeDefinition.getCharacter("BOTTOM_RIGHT_CORNER", Symbols.SINGLE_LINE_BOTTOM_RIGHT_CORNER);
        	char topRightCorner = themeDefinition.getCharacter("TOP_RIGHT_CORNER", Symbols.SINGLE_LINE_TOP_RIGHT_CORNER);

            TerminalSize drawableArea = graphics.getSize();
            graphics.applyThemeStyle(themeDefinition.getPreLight());
            graphics.drawLine(new TerminalPosition(0, drawableArea.getRows() - 2), new TerminalPosition(0, 1), verticalLine);
            graphics.drawLine(new TerminalPosition(1, 0), new TerminalPosition(drawableArea.getColumns() - 2, 0), horizontalLine);
            graphics.setCharacter(0, 0, topLeftCorner);
            graphics.setCharacter(0, drawableArea.getRows() - 1, bottomLeftCorner);

            graphics.applyThemeStyle(themeDefinition.getNormal());

            graphics.drawLine(
					new TerminalPosition(drawableArea.getColumns() - 1, 1),
					new TerminalPosition(drawableArea.getColumns() - 1, drawableArea.getRows() - 2),
					verticalLine);
            graphics.drawLine(
					new TerminalPosition(1, drawableArea.getRows() - 1),
					new TerminalPosition(drawableArea.getColumns() - 2, drawableArea.getRows() - 1),
					horizontalLine);

            graphics.setCharacter(drawableArea.getColumns() - 1, 0, topRightCorner);
            graphics.setCharacter(drawableArea.getColumns() - 1, drawableArea.getRows() - 1, (char)bottomRightCorner);

            if (!String.IsNullOrEmpty(title)) {
                graphics.putString(2, 0, TerminalTextUtils.fitString(title, drawableArea.getColumns() - 3));
            }

            return (TextGUIGraphics)graphics.newTextGraphics(new TerminalPosition(1, 1), graphics.getSize().withRelativeColumns(-2).withRelativeRows(-2));
        }

        public virtual TerminalSize getDecoratedSize(Window window, TerminalSize contentAreaSize) {
            return contentAreaSize
					.withRelativeColumns(2)
					.withRelativeRows(2)
					.max(new TerminalSize(TerminalTextUtils.getColumnWidth(window.getTitle()) + 4, 1));  //Make sure the title fits!
        }

        private static TerminalPosition OFFSET = new TerminalPosition(1, 1);

        public virtual TerminalPosition getOffset(Window window) {
            return DefaultWindowDecorationRenderer.OFFSET;
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
Diagnostic Accuracy of Immunohistochemistry in Detecting MGMT Methylation Status in Patients with Glioma
Nita Sahara 1
Rachmat Andi Hartanto 2
Naomi Yoshuantari 1
Kusumo Dananjoyo 3
Irianiwati Widodo 1
Rusdy Ghazali Malueka 3
Ery Kus Dwianingsih 1
1 Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia.
2 Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia.
3 Department of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada (FK-KMK UGM), Dr. Sardjito General Hospital, Yogyakarta, Indonesia.
Background: The O6-methylguanine-DNA methyltransferase (MGMT) gene prevents mismatch in DNA replication and transcription by repairing mutagenic DNA lesions. MGMT is a predictor biomarker of chemotherapy in high-grade and low-grade gliomas based on high-risk clinical conditions. It also can be used for therapeutic decisions to predict hypermutation in recurrence in newly diagnosed low-grade gliomas. The gold standard examination for the methylation is Polymerase Chain Reaction (PCR). However, this technique is not widely available in Indonesia for daily practice. Thus, an uncomplicated and simpler method such as immunohistochemistry (IHC) is needed as an alternative examination. This study aimed to predict the diagnostic accuracy of immunohistochemistry (IHC) in detecting the methylation status of O6-methylguanine-DNA methyltransferase (MGMT) in glioma. Methods: This research was a cross-sectional study using formalin-fixed paraffin embedded (FFPE) tissue samples of glioma patients, dating between October 2017 until March 2021. Diagnosis of glioma was established based on clinical, radiological, and histopathological findings. MGMT methylation status was investigated using the IHC and PCR techniques. Diagnostic value of IHC was analyzed, with PCR as a gold standard method. Optimum threshold to determine positivity of IHC was determined by the Area Under the Curve (AUC) on Receiver Operating Characteristics (ROC) curve and Youden index. Results: Among 75 samples examined, 29 (38.7%) patients were methylated. IHC detected MGMT methylation with sensitivity of 86.2%, specificity of 63.0%, positive predictive value of 59.5%, negative predictive value of 87.9% and accuracy of 72.0%. The AUC was 0.746, indicating moderate diagnostic value. Optimum positivity threshold of the IHC examination based on Youden Index was 10%. Conclusion: IHC examination can be used to detect MGMT methylation status of glioma patients in limited resources setting, where PCR technique is not available.
methylated MGMT
diagnostic accuracy
Anatomical pathology (including cytopathology)
Revise Date: 01 October 2021
Accept Date: 14 December 2021
Sahara, N., Hartanto, R., Yoshuantari, N., Dananjoyo, K., Widodo, I., Malueka, R., Dwianingsih, E. (2021). Diagnostic Accuracy of Immunohistochemistry in Detecting MGMT Methylation Status in Patients with Glioma. Asian Pacific Journal of Cancer Prevention, 22(12), 3803-3808. doi: 10.31557/APJCP.2021.22.12.3803
Nita Sahara; Rachmat Andi Hartanto; Naomi Yoshuantari; Kusumo Dananjoyo; Irianiwati Widodo; Rusdy Ghazali Malueka; Ery Kus Dwianingsih. "Diagnostic Accuracy of Immunohistochemistry in Detecting MGMT Methylation Status in Patients with Glioma". Asian Pacific Journal of Cancer Prevention, 22, 12, 2021, 3803-3808. doi: 10.31557/APJCP.2021.22.12.3803
Sahara, N., Hartanto, R., Yoshuantari, N., Dananjoyo, K., Widodo, I., Malueka, R., Dwianingsih, E. (2021). 'Diagnostic Accuracy of Immunohistochemistry in Detecting MGMT Methylation Status in Patients with Glioma', Asian Pacific Journal of Cancer Prevention, 22(12), pp. 3803-3808. doi: 10.31557/APJCP.2021.22.12.3803
Sahara, N., Hartanto, R., Yoshuantari, N., Dananjoyo, K., Widodo, I., Malueka, R., Dwianingsih, E. Diagnostic Accuracy of Immunohistochemistry in Detecting MGMT Methylation Status in Patients with Glioma. Asian Pacific Journal of Cancer Prevention, 2021; 22(12): 3803-3808. doi: 10.31557/APJCP.2021.22.12.3803


text:
Q: JSONP PHP Array Empty im trying to get data via JSONP from my Webpage with a php script :
//connection and query above
 ...

 while($r=mysqli_fetch_array($result)){
    //Add the fetched vale to $json array
    $json[] = $r;
     // Content type
  header("Content-type: application/json");
    echo "$callback({email: 'Message from Server.php'});";

  }

  // Content type
  header("Content-type: application/json");

  //JSONP - Make it as JSONP object

echo $_GET['callback']."(".json_encode($json).")";

my echo "$callback({email: 'Message from Server.php'});"; <--- works
but my
echo $_GET['callback']."(".json_encode($json).")"; <--- returns null
when i call the script on my webpage like "page/callback.php"
i get following outputs in my Browser :
    ({email: 'Message from Server.php'});([{"0":"3","ID":"3","1":"dome","username":"dome","2":"vjvhrOWZYTq3qbrYfoE13A==","passwort":"vjvhrOWZYTq3qbrYfoE13A==","3":"mii@googlemail.com","email":"mii@googlemail.com","4":"0","active":"0","5":"hu","loc":"hu"}]

)

It contains -> "[" and "]"
my Java script is GWT :
        JsonpRequestBuilder jsonp = new JsonpRequestBuilder();
    jsonp.requestObject(URL.encode("http://webpage/callback.php?callback=test_clbk"), new AsyncCallback<JSONreceiver>() {
        public void onFailure(Throwable throwable) {
            System.out.println(throwable.getMessage());
        }
        @SuppressWarnings("unused")
        public void onSuccess(JSONreceiver result) {
            System.out.println(result.getResult());
        }
    });

A: You still do not have any answer.
Here is one solution :
1) Remove EVERY SINGLE echo / print / var_dump.
2) Initiate the json class with a callback
3) Forge your JSON with Simple JSON for PHP
4) Send your json at the end of the file
The results :
<?php

include('../includes/json.php');

// Set a callback
$json = new json('callback', 'mycallback');

// Forge your data
$json->add('email', 'message sent from Server.php');

while($r=mysqli_fetch_array($result)){
  $answer[] = $r;
}

// Forge your data
$json->add('data', $answer);
$json->add('status', '200');

// Send
$json->send();

?>


Thanksgiving is a time to remember how much we rely upon and are grateful for the earth's bounty. Children learn the story behind the first Thanksgiving celebration, traditionally the American harvest holiday, and they visit Plimoth Plantation. Nanticoke tribe dancers re-create the sense of excitement and wonder the Pilgrims must have felt upon meeting the Native Americans. Children learn an Abnaki tribe myth on the origin of corn that teaches the importance of sharing resources, and a craft demonstration shows how to make a miniature Mayflower from walnut shells. Part of the multivolume Holidays for Children DVD Series. A teacher's guide is included and is available online.


text:
FRANCE TECHNOLOGY AND AUTOMOTİVE
France is strong in the technology, in the automotive world. The TGV holds the official speed record in 2007 with 574 km / h. This article will discover in a few lines, French car brands.
It's an Italian brand since 1909 and everyone knows it. But Bugatti is also baptized French. Since 1910, the manufacturer creates Bugatti Type 13 in France. Currently, Bugatti Chiron is the most expensive car produced and sold in France Bugatti just revealed a $3.3 million Chiron — and it's the ultimate hypercar.
The manufacturer was born in France in 1978. It is a genuine French brand since the models C, DS etc. It is the second most expensive produced and sold in France with SPaceTourer.
Started in 1889, it is an authentic brand. Since 1894,it will sit down its performance. Important standard models to his credit, namely: 308, 3008, 208, RCZ and even his electric models. The 508 RXH is a high-end car that is one of the most expensive cars in France.
Whose father Louis Renault is French, starts in 1898 with the Renault type A. It also became known with its electric model ZOE. Since then, it has built very beautiful models (Alaskan, Captur, Clio, Space, Kangoo, SCenic, Megane, Kadjar, Talisman etc.). In 1999, it merged with Nissan, and in 2017 with Mitsubishi.
It is a brand created in Taiwan in 1964, and specialized in the manufacture of Scooter motorcycles in association with Piaggio, the Italian group. Decided to go solo in 1985 to create her own models. In 1990, she returned to France with scooters. Later it specializes in sports vehicles with her models CEVENNE, HEMERA, SPEEDSTER etc.
It is a subsidiary of the brand Renault if not a Roman builder.Founded in 1966, the manufacturer delivers its models under the name Dacia in Europe and Renault in other parts of the world. These models include: Sandero, Duster, Logan, Lodgy etc.
The list is not complete. We can note among others, SOCEMA GREGOIRE, TALBOT, NEIGHBORHOOD, SLAMSON, SECMA, SIMCA, CG, DB, Venturi etc.
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