To conclude my time in New York, my last meal in the City would also be a first: the first pizzeria in the country that is. Lombardi's was opened by Gennaro Lombardi over a century ago in 1897 as a grocery store. In 1905, employee Antonio "Totonno" Pero began selling tomato pies, which proved immensely popular. Lombardi's pizza was modeled after the original Neapolitan variety, though mozzarella fior di latte was substituted for Mozzarella di Bufala, and a coal oven for a wood-burning one--thus the New York pizza was born. In 1924, Totonno left Lombardi's and opened Totonno's, his own pizzeria on Coney Island that still stands today. Interestingly, the current Lombardi's isn't at the location of the original. In 1984, the original restaurant closed, but reopened a decade later at another address only a block away (the location chosen for its early 1900's-era coal oven), this time under the auspices of Jerry Lombardi, Gennaro Lombardi's grandson, and his friend John Brescio. Lombardi's is currently owned and operated by Brescio, with Lombardi having retired from the business.
Lombardi's is located at the intersection of Spring and Mott streets in NoLIta (North of Little Italy); the area used to be part of Little Italy, but as Italians began moving out of the vicinity, the neighborhood started losing its distinctly Italian flavor. In any case, the restaurant has expanded over the years to meet increased customer demand; in the second photo, the original part of the restaurant is on the right, while the additions are to the left.
Here we see the dining room and bar in the newer part of the restaurant, near the main entrance. The new addition nearly doubled the size of the restaurant, reducing waiting times significantly.
Pictured above is one half of the original space; the other half is to the right, on the other side of the wall.
The menu is straightforward; click for larger versions. In addition to its classic Margherita pizza, Lombardi's is also well-known for its Clam Pie. The restaurant is somewhat unusual in that it does not sell pizza by the slice. Apparently, that concept was popularized by Patsy's Pizzeria in Harlem.
A small selection of drinks is available, including a few locally-brewed beers and some house wine. Nothing fancy, as expected. Click for larger versions.
The bar couldn't do a Mojito, so I decided (based on my experience at The Bazaar) on an Americano [$8.00] instead, comprised of Campari, sweet vermouth, and club soda. Surprisingly, the bartender was unaware of the drink, having to consult an electronic guide to figure the necessary ingredients. Though not as tasty as The Bazaar's version (this one being far more bitter), I still enjoyed the drink and found it appropriate as an aperitif.
In addition, I also ordered a glass of Brooklyn Lager [$6.00] and one of Sixpoint's Sweet Action Cream Ale [$6.00]. Brooklyn Lager comes from The Brooklyn Brewery and was a fairly typical example of the style--dry and mildly hoppy with a slight bitterness--and paired well with the pizza. The Sweet Action also hails from Brooklyn, and, as can be seen above, was a much hazier beer. It had a nutty, honeyed nose but a surprisingly dry, clean, citrusy taste; I wished it were creamier, as the name would suggest.
We decided to go with Gennaro's Original Margarita (Fresh Mozzarella, San Marzano Tomato Sauce, Pecorino Romano, Fresh Basil) with the signature toppings of Homemade Meatballs (Beef with Pork) and Hormel Rosa Grande Pepperoni on one half. The pizza begins with the crust, made with high-gluten flour, which is charred on the bottom by a 900-degree coal-powered heat, giving it a somewhat smoky-bitter flavor; this, however, yields a soft, almost creamy interior. The crust was indeed extremely thin, which I liked, but I thought it could've been crispier. I've heard that the secret to the crust lies in the use of New York City tap water, and that certain pizzerias outside of the City have actually imported said water for use in pizzas!
Next comes the sauce (made from puréed San Marzano tomatoes--the only type allowed in true Neapolitan pizza), which was actually quite pleasantly tart, with just a hint of basil. The use of low-moisture cow's milk mozzarella (from whole or part skim milk) along with Pecorino Romano was a nice touch as well, with the Pecorino adding a somewhat saltier tang to the milder mozzarella. Finally, the meat toppings were among the best I've had of their respective varieties, both being extraordinarily flavorful; I especially enjoyed the crispiness of the pepperoni slices.
What a world of difference compared to Famous Original Ray's! Perhaps it had something to do with the location, the aura of being at pizza ground zero, but this was truly some of the best, most memorable pizza I've had. My prior pizza experiences have been mostly with chains, so it was refreshing to see pizza done right, by pizzaiolos with a passion, a desire, to do things the right way. The result really speaks for itself, and makes me yearn for a place like this back in Southern California.
I remember my friends and I walked out of this place and said "what's the big deal?" Didn't hurt that our crust was mildly burnt! It was good but maybe it was far too hyped up for me so that my expectations for the pizza could never be met.
Glad your experience was better than mine and that enjoyed this NY institution tho!
If you're hankering for a thin style pizza you can check out Bollini's Pizzeria in Monterey Park (yeah weird place). Wood fire baked oven with a very reasonable price.
I'm a big fan of thing crust pizza. You can fold it in half and eat it like a sandwich!
This pizza pie looks fabulous. Next time I'm in New York (whenever that may be) this is a must do. I think I'd have to give the clam pie a whirl.
Charlie: I liked the burnt crust! I definitely understand the hype factor though. First pizzeria? Yeah that's a lot to live up to. In any case, Bollini's does seem really promising; I've been hearing a lot of good things.
Mike: I'm a fan as well. I wanted to do the clam pie, but my dining companion didn't want to.
Coming off food poisoning do you think clams really sound appetizing?
Does anything really sound appetizing?
Bollini's is horrible. Horrible. Go to Casa Bianca. It's not wood fired, but it's still really good. Or check out Pitfire pizza.
Wow. Why the hatred for Bollini's? A lot of people seem to enjoy it. Pizza's a polarizing issue it seems.
I'm usually not a stickler for pizza. I wouldnt' consider myself a "purist" at all, but the crust at Bollini's was bland and poorly done, the toppings were way overloaded and the sauce was much too sweet. I have no idea where they get the notion that they can call themselves "authentic neopolitan". I haven't been to Naples, but I've been to Antica Pizzeria, which also has the official Neopolitan designation and that one was like night and day compared to the one I had at Bollini's. In either even, go there and try it yourself. I bet it'll be nothing like what you had at Lombardi's. Sorry, I was really disappointed when I finally went there, being that I heard tons of great things about it too.
Ah, thanks for the clarification. Perhaps I do need to try it for myself. Are there any other pizza places that you're not keen on?
Next time you're in Los Angeles go to Village Pizzeria in West Hollywood. Talk about a good slice! I was visiting from New York City, in fact, and a friend took me. Better than a lot of the pizza places in NYC, and cheaper too.
I'm not familiar with a Village Pizzeria in West Hollywood. Did you mean the one on Larchmont or the one on Yucca? Or did you mean Greenwich Village Pizzeria?
I believe that both the one on Yucca as well as the one on Larchmont are owned by the same people, but I went to the one on Larchmont Blvd. Sorry, I'm not very familiar with L.A.!
Yeah I think Grimaldi's was previously known as Patsy's. I do want to try both of them eventually, and Di Fara as well.
I tried Lombardi's and Grimaldi's last month, and Lombardi's wins by a nose. It's a shame you didn't try Lombardi's roasted marinated red peppers as a topping. They cook them first in the coal oven, giving them a slight smokey flavor as well as a little char. Then when they are put on your pizza, all they have to do is heat up. Perfecto! At Grimaldi's the marinated peppers were taken right out of the jar. Because these thin crust pizzas cook so quickly, the red peppers were a little slimey. Also Lombardi's sausage was much better. Again pre-cooked and then thinly sliced like a deli meat. Grimaldi's put on crumbled raw sausage. While it had a nice flavor, it was a little gristley in parts. I think you've had the best of the two pies. And both are better than anything I've had here, although Tony's Little Italy in Placentia is Chicago Deep Dish at it's best. But you can't compare Deep Dish and Thin Crust, they are two different animals.
Hey thanks for the very detailed report back on the two places Dave! I still would be interested in trying Grimaldi's if I'm ever back, and the much-hyped Di Fara too.
Lol. "Entire universe" is a bit of a hyperbole I'm sure. Is it even the best in NYC? Most would say no.
I actually wanted to hit up Di Fara last time, but the distance (we were staying in Midtown) and potential ginormous line kept us away.
If you ever go to NYC again..I know its not Pizza but the Halal cart specifically for the lamb is very good...truly live up to the hype.
There are some cool drinking places also. The one top chef place I did visit was Morimoto, to me the Omakase was more like Ikko good but sushi wise not exceptional. Maybe I had too much expectation as well. If morimoto made it himself it might be different. Morimoto is kinda like Nobu to me.
Yeah I've heard a lot about the cart--will try to seek it out next time.
Morimoto is way down on my list to try in NYC though. I would try it out in Philly however.


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Limitations - Statutory Limitation - Discoverability
Fanshawe College of Applied Arts and Technology v. AU Optronics Corporation (Ont CA, 2016)
In this case the Court of Appeal held that a statutory limitation period which commenced running on "a day on which the conduct was engaged in", was subject to the discoverability principle despite the absence of it's adoption in the statute:
(ii) Did the motion judge err in finding that the discoverability principle applies to the limitation period found in s. 36(4)(a)(i) of the Competition Act?
No. Subsection 36(4)(a)(i) is subject to the discoverability principle. A statutory limitation period will generally be subject to the discoverability principle when the running of the limitation period is linked either to the plaintiff's knowledge about an event or to an event related to the plaintiff's cause of action. The limitation period in s. 36(4)(a)(i) is triggered by an event related to the underlying cause of action – specifically, conduct contrary to Part VI of the Competition Act. Therefore, it is subject to discoverability.
[32] The discoverability principle is a common law rule providing that "a cause of action arises for purposes of a limitation period when the material facts on which it is based have been discovered or ought to have been discovered by the plaintiff by the exercise of reasonable diligence": Central Trust Co. v. Rafuse, 1986 CanLII 29 (SCC), [1986] 2 S.C.R. 147, at p. 224; see also Graeme Mew, Debra Rolph & Daniel Zacks, The Law of Limitations, 3rd ed. (Toronto: LexisNexis Canada Inc., 2016), at p. 75.
[33] Discoverability is also an interpretive rule relevant to the construction of limitation statutes: Ryan v. Moore, 2005 SCC 38 (CanLII), [2005] 2 S.C.R. 53, at para. 23. As explained below, it provides certain presumptions for courts interpreting statutory limitation periods.
[34] The approach for determining whether a particular statutory limitation period is subject to the discoverability principle was discussed by Twaddle J.A. in Fehr v. Jacob (1993), 1993 CanLII 4407 (MB CA), 14 C.C.L.T. (2d) 200 (Man. C.A.), at p. 206:
[T]he judge-made discoverability rule is nothing more than a rule of construction. Whenever a statute requires an action to be commenced within a specified time from the happening of a specific event, the statutory language must be construed. When time runs from "the accrual of the cause of action" or from some other event which can be construed as occurring only when the injured party has knowledge of the injury sustained, the judge-made discoverability rule applies. But, when time runs from an event which clearly occurs without regard to the injured party's knowledge, the judge-made discoverability rule may not extend the period the legislature has prescribed.
The Supreme Court of Canada has endorsed this passage in Peixeiro v. Haberman, 1997 CanLII 325 (SCC), [1997] 3 S.C.R. 549, at para. 37, and in Ryan, at para. 23.
[35] Ryan is the latest statement from the Supreme Court of Canada on this issue. In that decision, at para. 24, Bastarache J. concluded as follows:
Thus, the Court of Appeal of Newfoundland and Labrador is correct in stating that the rule is "generally" applicable where the commencement of the limitation period is related by the legislation to the arising or accrual of the cause of action. The law does not permit resort to the judge-made discoverability rule when the limitation period is explicitly linked by the governing legislation to a fixed event unrelated to the injured party's knowledge or the basis of the cause of action.
[36] The applicability of discoverability is a matter of statutory construction. The jurisprudence noted above only provides presumptions and, in Ryan, at para. 23, Bastarache J. cautioned against applying the principle automatically or "systematically without a thorough balancing of competing interests".
[37] With these general principles in mind, I turn to a consideration of the limitation period in s. 36(4)(a)(i), which provides the following:
(4) No action may be brought under subsection (1),
(a) in the case of an action based on conduct that is contrary to any provision of Part VI, after two years from
(i) a day on which the conduct was engaged in, or
(ii) the day on which any criminal proceedings relating thereto were finally disposed of,
whichever is the later…
[38] I begin by discussing Ryan and Waschkowski v. Hopkinson Estate (2000), 2000 CanLII 5646 (ON CA), 47 O.R. (3d) 370 (C.A.), both relied upon by HannStar, where courts found that the limitation period in issue was not subject to discoverability.
[39] Ryan considered the limitation period in s. 5 of the Survival of Actions Act, R.S.N.L. 1990, c. S-32, which linked the limitation period to the granting of letters of probate or the death of a defendant. In Waschkowski, this court considered s. 38(3) of the Trustee Act, R.S.O. 1990, c. T.23, which linked the limitation period to the death of a deceased.
[40] In both cases, the courts noted that the event that triggered the running of the limitation period at issue – the issuing of letters probate or the death of the defendant – did not affect the plaintiff's cause of action and the plaintiff's knowledge of the event at issue was irrelevant to their cause of action: Ryan, at para. 32; Waschkowski, at para. 8. In contrast, the "conduct" mentioned in s. 36(4)(a)(i) is not unrelated to the claimant's cause of action; rather, it is the basis for the plaintiff's claim.
[41] I turn now to a consideration of Peixeiro and of Grenier v. Canadian General Insurance Company (1999), 1999 CanLII 2156 (ON CA), 43 O.R. (3d) 715 (C.A.), two cases where courts found that the limitation period in issue was subject to discoverability.
[42] In Peixeiro, the limitation period is similar to the one at issue in the present case. There, the Supreme Court considered what was s. 206(1) of the Highway Traffic Act, R.S.O. 1990, c. H.8, which provided that any action for damages caused by a motor vehicle accident had to be brought within "two years from the time when the damages were sustained." The court concluded that the discoverability principle applied. Major J.'s comments, at para. 38, are instructive:
The appellant submitted here that the general rule of discoverability was ousted because the legislature used the words "damages were sustained", rather than the date "when the cause of action arose". It is unlikely that by using the words "damages were sustained", the legislature intended that the determination of the starting point of the limitation period should take place without regard to the injured party's knowledge. It would require clearer language to displace the general rule of discoverability. The use of the phrase "damages were sustained" rather than "cause of action arose", in the context of the HTA, is a distinction without a difference. The discoverability rule has been applied by this Court even to statutes of limitation in which plain construction of the language used would appear to exclude the operation of the rule. Kamloops, supra, dealt in part with s. 739 of the Municipal Act, R.S.B.C. 1960, c. 255, which required that notice should be given within two months "from and after the date on which [the] damage was sustained". However, this Court applied the discoverability rule even with respect to this section. [Citation omitted.]
[43] Subsection 36(4)(a)(i) links the limitation period to conduct that gives rise to any damage or loss. In that way, it is similar to the former s. 206 of the Highway Traffic Act, which linked the limitation period to damages caused by a motor vehicle accident.
[44] Also instructive is this court's decision in Grenier in which the issue was whether the discoverability principle applied to the old s. 258(2) of the Insurance Act, R.S.O. 1990, c. I.8, which provided as follows: "No action shall be brought against an insurer under subsection (1) after the expiration of one year from the final determination of the action against the insured, including appeals if any." At p. 722, Morden A.C.J.O. concluded that the discoverability principle applied:
With respect, I do not think that the triggering event in s. 258(2) of the Insurance Act – the final determination of the action against the insured – is the same as that in Fehr. It is a constituent element of the cause of action which is created by s. 258(1) – a judgment against a person insured by a motor vehicle liability policy. Under the discoverability rule this triggering event does not come into existence until the plaintiff has, or reasonably should have, knowledge not only that he or she has a judgment but, also, that it is a judgment against an insured person. [Emphasis in original.]
[45] Similarly, in this case, the term "conduct" in s. 36(4)(a)(i) of the Competition Act refers to the conduct giving rise to damages mentioned in s. 36(1) and is, therefore, also a constituent element of the cause of action subject to the limitation period. To use Bastarache J.'s language from Ryan, quoted above, the triggering event is related to the accrual of the cause of action. Applying the rationale from Grenier, s. 36(4)(a)(i) too is subject to the discoverability principle.
[46] Also, in Peixeiro, at para. 39, Major J. stated the following:
In balancing the defendant's legitimate interest in respecting limitations periods and the interest of the plaintiffs, the fundamental unfairness of requiring a plaintiff to bring a cause of action before he could reasonably have discovered that he had a cause of action is a compelling consideration.
In my view, that applies in the present case as well, particularly given that secrecy and deception are invariably elements of anti-competition agreements.
[47] I note that s. 36(4)(a)(ii) provides an alternative date for the limitation period (i.e. the day on which any criminal proceedings relating to the conduct at issue were disposed of). That alternate event is arguably not connected to a plaintiff's cause of action or knowledge – at the very least it is clearly not a constituent element of the cause of action provided in s. 36 of the Competition Act. As such, it imposes a limitation period that is probably not subject to discoverability. One could argue that this produces an anomalous result in that the discoverability principle would apply to s. 36(4)(a)(i) but not to s. 36(4)(a)(ii). However, I do not think such an outcome would be anomalous. There is no rule that suggests that both limitation periods in s. 36(4)(a) must operate in the same way.
[48] I agree with the statements of Sharpe J. in Chadha v. Bayer Inc. (1998), 1998 CanLII 14791 (ON SC), 82 C.P.R. (3d) 202 (Ont. Gen. Div.) about s. 36(4)(a)(i) and (ii). In concluding that it was not beyond doubt that the discoverability principle did not apply to s. 36(4)(a)(i), he noted, at p. 206, that "Parliament has hardly provided potential defendants with an iron-clad assurance that they may not be sued more [than] two years after the cessation of their conduct as the limitation period could start to run again in the event of criminal proceedings."
[49] I also agree with the submission of Fanshawe that any other interpretation has the potential to render the remedy nugatory by depriving victims of the chance to make a claim when the conspirators' concealment has been particularly effective.
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The newly refurbished Maritim Jolie Ville Kings Island Luxor is a quality hotel in a unique location on the all-private Kings Island, in the centre of the Nile in Luxor. With well-tended, landscaped gardens and an peaceful atmosphere, the Maritim Jolie Ville is a tranquil retreat for guests after the bustle of downtown Luxor. Renovated and extended in 2010, the Maritim Jolie Ville Kings Island offers comprehensive, family friendly facilities including an extensive pool complex and spa.
The Maritim Jolie Ville Kings Island Luxor is located on a private island in the centre of the Nile in Luxor, about 4km from many of the city's main attractions. Mainland Luxor is accessible by bridge and a complimentary shuttle bus service operates to central Luxor.
Comfort rooms are 24m2, while Deluxe rooms were recently built and are a spacious 43m2.
Superior Deluxe rooms are extra large, at 53m2, and are located in the recently built bungalows.
Jolie Suites are 48m2, with a separate sitting area.
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La Fleur: International a la carte cuisine, served in an sophisticated atmosphere. Open for lunch and dinner.
Jolie Ville Buffet Restaurant: The Maritim Jolie Ville's main restaurant, offering buffet breakfast and themed dinner buffets.
Scherazade Terrace: Located in the gardens, with views over the Nile. Serves barbecued specialities, baked goods, ice cream, pizza and sandwiches as well as traditional Egyptian snacks. Open for lunch and dinner.
Zigolini: A la carte Italian cuisine for lunch and dinner.
Nubian Farm House: A welcoming kitchen-style restaurant offering local specialities.
Lobby Bar: Serves a selection of drinks, ice cream and snacks. Open until midnight.
Ascot Bar: Speciality drinks and live entertainment in the evening. Open until 2am.
Fellah's Tent: Oriental cuisine with evening entertainment.
The Maritim Jolie Ville Kings Island Luxor is sold on a bed and breakfast basis, which includes buffet breakfast in the main restaurant.
Integrated swimming pool areas with waterfall, children's pool, horizon pool and tranquility pool.
Live music and entertainment in the evening.


World Refugee Day 20 June 2015 Today is World Refugee Day, 1 in 122 are displaced, 40,000 more each day from conflicts and geopolitical interference. Millions from Syria, Afghanistan, Iraq, Africa, South East Asia, have become refugees and asylum seekers.
Samoan Fa'afafine Jaiyeh Saelua is the world's first international transgender footballer recognised and supported by FIFA. She is part of the Samoan third gender culture, the word fa'afafine being made up of the prefix fa'a meaning "in the manner of"
Facebook Messenger App Permissions Automated Access Reports, True or False?


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CRI BlogSeptember 2017
CICON17 Day 1 Recap: Neoantigens, Vaccines, and Overcoming Immunotherapy Resistance
Arthur N. Brodsky, Ph.D.
The third International Cancer Immunotherapy Conference (CICON17) organized by the Cancer Research Institute (CRI), the Association for Cancer Immunotherapy (CIMT), the European Academy of Tumor Immunology (EATI), and the American Association for Cancer Research (AACR), began on September 6, 2017, in Mainz, Germany along the banks of the Rhine River just thirty minutes away from bustling Frankfurt. More than 1,400 scientists from around the world are in attendance to hear the latest laboratory and clinical research in cancer immunotherapy.
SESSION 1: NEOANTIGENS
Opening the first session on Day 1 was The Netherlands Cancer Institute's Ton N. Schumacher, Ph.D., with a talk on how immune cells called T cells recognize cancer. Specifically, how they recognize cancer neoantigens (neo = new, antigen = something the immune system detects), tumor markers that arise from mutations that T cells recognize via the T cell receptor (TCR).
Unfortunately, tumors can escape immune elimination and "exhaust" T cells by expressing another molecule, PD-L1, which activates the PD-1 immune checkpoint, a key pathway for deactivating T cells. As revealed in his recent Nature paper with Chong Sun, Ph.D., Schumacher explained how with genome-wide screening he identified CMTM6 along with a related "backup" molecule CMTM4 as important regulators of PD-L1 expression. Without CMTM6, the stability and presence of the PD-L1 protein was significantly diminished. Furthermore, a talk later in the day by Marian Burr, Ph.D., of the Peter MacCallum Cancer Centre and the Cambridge Institute for Medical Research, showed in mice that surface PD-L1 is rapidly degraded in cells lacking CMTM6, which was shown to protect PD-L1 from degradation. Thus, CMTM6's maintenance of PD-L1 expression also regulated anti-tumor immunity, at least in mice.
Dr. Schumacher also investigated the ability of T cells in patients' tumors to recognize cancer cells, and highlighted a new technique his team developed that enables them to accurately evaluate the tumor-targeting potential of T cells inside patient tumors, known as tumor infiltrating lymphocytes. With this, he showed that not all T cells that target tumor neoantigens are "equal" in their ability to attack tumors, and stressed the need for more sophisticated tests, or assays, to properly determine which neoepitopes—smaller bits of neoantigenic proteins that are actually "seen" by the T cell receptor—are most likely to lead to effective anti-tumor responses. Building on that, he pointed out that some of the "exhausted" T cells found in tumors might be irrelevant when it comes to these anti-tumor responses, and that strategies to reinvigorate exhausted T cells should take this into consideration.
Following Schumacher was BioNTech's Ugur Sahin, M.D., the morning session chair, who discussed the challenges facing personalized cancer vaccines: namely, that every patient is different, and even within a single patient the tumor cells can vary widely in their identity and behavior over time. He made the case, however, that we must confront this complexity by uncovering more information relevant to immunotherapy strategies, which would—borrowing from a modern manufacturing term for maximizing efficiencies and lowering costs— allow for the "just in time" design and production of individually tailored treatments.
In a clinical trial involving patients with stage 3 or 4 melanoma, Sahin demonstrated that personalized RNA vaccines enhanced tumor-specific T cell responses (against at least 3 tumor targets) within 2-4 weeks, and led to the presence of important memory T cells that can help provide long-term protection. Additionally, he showed that the majority of neoantigens (57%) were recognized by CD4+ T cells, while only 17% were recognized by CD8+ T cells and 26% were recognized by both.
Thus far, 5 of the 19 patients treated have experienced objective responses: two patients had complete responses to the vaccine alone, while one had a complete response to the vaccine in combination with anti-PD-1 checkpoint immunotherapy. Furthermore, there was evidence of vaccine-induced antigen spread, meaning that the immune system recognized and responded against tumor-specific neoantigens that weren't even targeted by the vaccine. Antigen spreading is believed to be an important factor in the immune system's ability to adapt to changes in cancer and provide durable protection.
Finally, Sahin discussed his team's use of liposomes (essentially hollow fatty spheres) to deliver these RNA vaccines directly to dendritic cells, which can coordinate systemic immune responses. Already the approach—which can overcome the weak immune-stimulating ability of some antigens—has been successful in mice, and is now being evaluated in a first-in-human clinical trial. Preliminary results from the trial have been promising in terms of preventing relapse in disease-free patients as well as inducing therapeutic responses in checkpoint immunotherapy-treated patients with measurable disease. These liposomal vaccines have also shown synergy in combination with anti-PD-1 checkpoint immunotherapy.
Next, Stephen P. Schoenberger, Ph.D., who co-directs (with Ezra Cohen, M.D.) the San Diego Center for Precision Immunotherapy at the University of California, San Diego (UCSD), highlighted an improved way to discover the best patient-specific neoantigens to target through immunotherapy, which revealed that spontaneously occurring T cell responses against tumors are readily detectable. Additionally, T cells that react against both driver (those that fuel cancerous behavior) and passenger (those "along for the ride") mutations were also found, and proteins resulting from DNA frameshift mutations were found to be especially immunogenic.
Building on previous approaches that rely on biopsies, genome sequencing, and T cell assays, Schoenberger's platform enables sorting of tumor-infiltrating T cells (also referred to as TILs) according to what types of antigens they target. This allows isolation of only the TILs that are reactive against tumor antigens and provides an improved product for adoptive cell [immuno]therapy (ACT). Thus far, these "TIL 2.0" have led to improved tumor control in mice, and worked even better in combination with anti-PD-1 checkpoint immunotherapy.
Following Schoenberger, Catherine Wu, M.D., of Harvard Medical School and the Dana-Farber Cancer Institute, discussed current cancer vaccine approaches and sought to address critical questions in cancer immunotherapy. In short, by expanding and broadening patients' repertoires of tumor-specific T cells, doctors can aim to stimulate highly specific anti-tumor immune responses that also spare healthy tissues from autoimmune attacks.
Putting this concept into practice, Wu used vaccines containing SLPs (synthetic long peptides) against 20 personalized tumor neoantigens per patient, along with the immune stimulant poly-ICLC. This was able to induce responses in both CD4+ (helper) and CD8+ (killer) T cells. Vaccination was also associated with major shifts in T cell gene expression, producing T cells that were "very energetic and excited to go forward."
In two previously-untreated metastatic melanoma patients who progressed after vaccination, subsequent treatment with anti-PD-1 immunotherapy was able to induce complete responses. While melanomas are typically heavily mutated, Wu also treated glioblastoma patients whose tumors were less mutated and observed successful induction of T cells against tumor-specific neoantigens. Finally, Wu stressed how the improved genome-mining and next-generation sequencing will allow for not only improved vaccination targets, but also (returning to the personalization theme) improved combination strategies tailored for individual patients.
Sine Reker Hadrup, Ph.D., of the Technical University of Denmark, spoke next on the field's inability to predict which neoantigens actually stimulate immune responses in the body, and then discussed her experiments that sought to learn what determines the immunogenicity of neoantigens (and their corresponding neoepitopes, the molecules actually targeted by T cells within the context of Major Histocompatibility Complex (MHC), a cellular apparatus that presents antigens to the immune system. To do so, she took an MHC-loaded epitope that contained 10 amino acids (AAs) and altered it by substituting different AAs into each of the 10 positions. By doing this, she produced almost 200 variants and made interesting observations concerning how these single AA changes influenced the ability of T cells to recognize the epitope.
N ext up was Memorial Sloan Kettering's Timothy Chan, M.D., Ph.D., who explained how large scale technologies that can predict neoantigens as well as the targets of TCRs theoretically allow doctors to build a better foundation for precision immunotherapy strategies. However, "how to really put this all together still eludes the field." Using MSKCC's IMPACT Platform to perform a pan-cancer analysis of mutational load and its influence on checkpoint immunotherapy responses, Chan showed that all cancers (with the exception of glioma) had a baseline number of mutations, above which more mutations were associated with improved survival after immunotherapy.
When it comes to resistance to checkpoint immunotherapy, Dr. Chan also demonstrated that—in addition to inactivating mutations in genes involved in antigen processing and presentation—mutations in two genes associated with a protein-cleaving enzyme called serine protease were found in melanoma patients and were associated with improved survival after anti-CTLA-4 checkpoint immunotherapy. Out of 18 patients with these mutations, 11 had complete responses (CR) to immunotherapy.
Lastly, Chan highlighted how tumors can evolve during treatment and provided potential evidence for the existence of immunoediting in human tumors. Immunoediting is a central concept in modern tumor immunology, described by Robert D. Schreiber, Ph.D., along with Gavin Dunn, M.D., Ph.D., and Lloyd J. Old, M.D., that characterizes the interaction over time between cancer and the immune system and how through a Darwinian type of selection the immune system shapes tumor "appearance" and behavior. Interestingly, the tumors of melanoma patients who responded anti-PD-1 checkpoint immunotherapy (and had improved overall and progression-free survival) were associated with tumor genomes that became less heterogeneous after treatment. This contrasted with the persistence of tumors' genomic landscapes in patients who didn't respond.
Céline Laumont, a Ph.D. candidate at the University of Montreal, followed up Chan's talk with her work that involved the development of a novel profiling approach which she used to identify five tumor-specific antigens (TSA) targets that were derived from the non-coding regions of the genome. Furthermore, she was able to delay or prevent the development of cancer in mice through the use of a prophylactic dendritic cell vaccine against the TSAs she identified.
Finishing up the first session on neoantigens was Memorial Sloan Kettering's Vinod Balachandran, M.D., who discussed the unique qualities of neoantigens found in rare long-term survivors of pancreatic cancer, a notoriously hard-to-treat tumor type with a historically low survival rate. Compared to short-term survivors, these long-term survivors had twelve times as many CD8+ killer T cells in their tumors and had enriched activity in the genes that control adaptive immunity as well as antigen processing and presentation.
Dr. Balachandran also developed a computational model to quantify a given tumor's immunogenicity, which takes into account the quality of its neoantigens as well as the tumor's heterogeneity (what proportion of the tumor cells express neoantigens). He found that the quality of neoantigens—not the quantity—could be used to stratify these long-term survivors and demonstrated prognostic survival value. In all seven of the long-term pancreatic cancer survivors he tested, he found reactivity against high quality neoantigens.
SESSION 2: NOVEL MECHANISMS OF IMMUNOSUPPRESSION AND IMMUNE EVASION
Nicholas Restifo, M.D., of the National Cancer Institute Center for Cancer Research, began the second session of Day 1 by discussing his use of genome-scale CRISPR-Cas9 editing—a tool used to target and modify DNA with great precision—to identify the genes that, when deleted, allow tumor cells to escape T cell recognition and elimination. Using three independent analysis methods that reproducibly overlapped, his team was able to identify four novel "weird" genes—APLNR, BBS1, COL17A1, and SOX10—that were crucial for the ability of T cells to target and eliminate tumors. Importantly, the top hits from their analysis also correlated with cancer-killing T cell activity in multiple cancer subtypes.
Next up was Padmanee Sharma, M.D., Ph.D., of the University of Texas MD Anderson Cancer Center, who sought to understand why some patients respond to checkpoint immunotherapy while others do not. To do so, she's turned to "reverse translation," or taking insights learned from patients and then going back to the lab to test hypotheses derived from them.
She focused especially on insights related to ICOS (Inducible CO-Stimulator), which belongs to the same family as the immune checkpoint CTLA-4, and revealed that ICOS expression in CD8+ killer T cells increased after they recognized their corresponding antigen in melanoma-bearing mice. Additionally, when the ICOS gene was deleted in T cells, it decreased their production of the important cytokine IFNg as well as Eomes. Because of this, Sharma hypothesized that the ICOS pathway could be targeted (activated, not blocked) through combination immunotherapy approaches to improve patient responses, and it did when combined with anti-CTLA-4 checkpoint immunotherapy in melanoma-bearing mice.
Furthermore, Sharma showed that treating patients with a combination of hormonal therapy and anti-CTLA-4 immunotherapy before surgery could convert "cold," non-immunogenic prostate tumors into "hot" tumors full of immune cells. However, as the tumors became more infiltrated by immune cells, they also increased expression of immune checkpoints such as PD-L1 and VISTA that can suppress the activity of those immune cells, thus providing a rationale for combination strategies targeting these checkpoints.
Jesse Zaretsky, a Ph.D. student in the lab of Antoni Ribas, M.D., Ph.D., at the University of California, Los Angeles (UCLA), spoke next and discussed the mechanisms of acquired resistance to anti-PD-1 checkpoint immunotherapy in melanoma. He showed that even during tumor relapse, there can still be tumor-targeting T cells present in the tumor, but the tumor cells have evolved to escape detection. Ribas and Zaretsky then used whole exome sequencing and (in separate cases) identified two mutations that disrupted signaling through the JAK pathway and one in B2M, which is involved in antigen presentation. While T cells could still recognize cancer cells that had lost JAK function, it's likely that it made the cancer cells more resistant to apoptosis, a form of programmed cell death.
Finally, AstraZeneca's Yumeng Mao, Ph.D., capped off the Day 1 talks by revealing how two enzymes—AXL and MerTK—associated with myeloid immune cells can suppress immune responses against tumors. Through experiments involving co-culture of tumor cells and immune cells, he showed that deficiency in either of these two proteins was able to improve activation of anti-tumor immune cells, including CD4+ T cells, CD8+ T cells, and natural killer cells. This could lead to new therapeutic targets to improve patient responses to immunotherapy.
The day concluded with a reception and poster session featuring more than 250 abstracts covering topics such as neoantigens and cancer mutations, oncolytic viruses, adoptive cell therapy, checkpoint blockade therapy, immunomonitoring and biomarkers, and cancer-mediated immune suppression.
That's it for our Day 1 coverage from CICON17. Check back tomorrow to see our coverage of Day 2 of the conference.
FDA Approves First CAR T Cell Immunotherapy for Leukemia
CICON17 Day 2 Recap: Biomarkers, Novel Agents, and Adoptive Cell Therapies


Sixteen years after his first solo exhibition in a museum, organised by the Mart at its former historic venue of Palazzo delle Albere, the works of Stefano Cagol return to Trento in a solo exhibition curated by Margherita de Pilati and Denis Isaia.
he show offers an overview of the many projects with which Stefano Cagol has developed a reflection on current events and social and cultural phenomena, interpreting them in an ironic, controversial and scathing manner.
In this chronological exhibition, the various phases of the artist's career are illustrated, from the early experiments concerning the language of video, to the most recent projects like "The Body of Energy (of the mind)", produced by the Germany RWE foundation and presented in a solo exhibition in Berlin and in a dozen European museums.
About 40 works will be on display, including the itinerant projects that have for years characterised Cagol's work, participatory projects, like the one realised at the Ilva of Taranto, and the work presented in the Maldives Pavilion at the 55th Venice Biennale "The ice monolith".


We are excited to be launching our two latest anthologies this week, on Saturday 19th January at St James Wine Vaults, in Bath, 7.30 pm - 10.00 pm. It's going to be a fun and pacy evening with readings of micro fictions (around 2 mins reading time each) from Flash Fiction Festival Two by writers who came to the second Flash Fiction Festival in Bristol last July in the first half of the evening and after a break for chats, drinks, cake and book buying, readings from some of the winning, shortlisted and longlisted writers who are published in Bath Flash Fiction Vol Three, Things Left And Found By The Side Of The Road.
Here's our list of fabulous flashers, some local and others travelling from all over the UK to be with us. Reading from Flash Fiction Festival Two: Carrie Etter; Alison Woodhouse; Matt Thorpe Coles; Jeanette Sheppard; Jude Higgins; Andrea Harman; John Wheway; Grace Palmer; Philip Webb Gregg, Dave Alcock, Alison Powell and Santino Prinzi. Many of these flash fictions were prompted by workshops at the festival.
And in the second half, the launch of Things Left and Found At The Side Of The Road, we're thrilled to begin with all-the-way-from Brighton, Jo Gatford, who wrote the title story and who won first prize in February 2018. She's followed by K M Elkes who won first prize in the June 2018 Award; Ingrid Jendrzejewski, a former first prize winner, also commended in June 2018; 2018, Conor Haughton, second prize in the June Award; Rosamund Davies; Steve Partridge; Diane Simmons; Steven John,Bronwen Griffith; Thomas Malloch; Gail Anderson and lastly, Tim Craig, third prize winner in the June round.
We'll have special cake, wine and nibbles a thirty minute break in between readings plus a late bar. All the Bath Flash Fiction Anthologies will be for sale plus other flash fiction books from NFFD and by some of our authors. Let us know asap if you are in the area and would like to come. We might be able to squeeze you in.


text:
Foster, Kim, Roche, Michael, Giandinoto, Jo-Ann and Furness, Trentham
There is widespread recognition that workplace stress can have profound negative impacts on nurses' well-being and practice. Resilience is a process of positive adaptation to stress and adversity. This study aimed to describe mental health nurses' most challenging workplace stressors, and their psychological well-being, workplace resilience, and level of caring behaviours, explore the relationships between these factors, and describe differences in workplace resilience for sociodemographic characteristics. In a descriptive correlational study using convenience sampling, data were collected from N = 498 nurses working in mental health roles or settings in Victoria Australia via an online cross-sectional survey. Key findings included weak to strong (r = 0.301 to r = 0.750) positive relationships between workplace resilience with psychological well-being across all stressor categories (consumer/carer; colleague; organizational role; and organizational service). Psychological well-being was moderately high, but lower for nurses indicating consumer/carer-related stressors as their most stressful challenge. There were weak to moderate (r = 0.306 to r = 0.549) positive relationships between workplace resilience and psychological well-being, and no relationship between resilience and caring behaviours. Workplace resilience was lower (P < 0.05) for less experienced nurses compared with those with >5 years' experience, and lower for younger nurses compared with those aged ≥40 years. To improve their resilience and prevent psychological distress, there is prime opportunity to support nursing students with well-being and resilience-building strategies during their undergraduate education, and to support new graduates with similar programmes when they enter the workforce.
workplace resilience; well-being; mental health nursing; workplace stress; practice
International Journal of Mental Health Nursing
29 (1), pp. 56-68
https://doi.org/10.1111/inm.12610
https://acuresearchbank.acu.edu.au/item/8w566/workplace-stressors-psychological-well-being-resilience-and-caring-behaviours-of-mental-health-nurses-a-descriptive-correlational-study
Datasets to support workforce planning in nursing : A scoping review
Weller-Newton, Jennifer M., Phillips, Craig, Roche, Michael A., McGillion, Anthony, Mapes, Jo, Dufty, Tania, Schlieff, Jo, Boyd, Leanne, Geary, Alanna and Haines, Stephanie. (2021). Datasets to support workforce planning in nursing : A scoping review. Collegian. 28(3), pp. 324-332. https://doi.org/10.1016/j.colegn.2020.09.001
Potential application of whole body vibration exercise for improving the clinical conditions of covid-19 infected individuals : A narrative review from the world association of vibration exercise experts (wavex) panel
Sañudo, Borja, Seixas, Adérito, Gloeckl, Rainer, Rittweger, Jörn, Rawer, Rainer, Taiar, Redha, van der Zee, Eddy A., van Heuvelen, Marieke J. G., Lacerda, Ana C., Sartorio, Alessandro, Bemben, Michael, Cochrane, Darryl, Furness, Trentham, de Sá-Caputo, Danúbia and Bernardo-Filho, Mario. (2020). Potential application of whole body vibration exercise for improving the clinical conditions of covid-19 infected individuals : A narrative review from the world association of vibration exercise experts (wavex) panel. International Journal of Environmental Research and Public Health. 17(10), p. 3650. https://doi.org/10.3390/ijerph17103650
Clarifying workforce flexibility from a division of labor perspective : A mixed methods study of an emergency department team
Wise, Sarah, Duffield, Christine, Fry, Margaret and Roche, Michael. (2020). Clarifying workforce flexibility from a division of labor perspective : A mixed methods study of an emergency department team. Human Resources for Health. 18(1), p. 17. https://doi.org/10.1186/s12960-020-0460-7
Care planning and nonpharmacological interventions in a metropolitan inpatient dual diagnosis service : A retrospective exploratory study
MacLeay, Euan, Fry, Margaret, Roche, Michael Anthony and Montilla, Tim. (2020). Care planning and nonpharmacological interventions in a metropolitan inpatient dual diagnosis service : A retrospective exploratory study. International Journal of Mental Health Nursing. 29(5), pp. 856-867. https://doi.org/10.1111/inm.12719
Uncovering the disconnect between nursing workforce policy intentions, implementation, and outcomes : Lessons learned from the addition of a nursing assistant role
Duffield, Christine, Twigg, Di, Roche, Michael, Williams, Anne and Wise, Sarah. (2019). Uncovering the disconnect between nursing workforce policy intentions, implementation, and outcomes : Lessons learned from the addition of a nursing assistant role. Policy Politics and Nursing Practice. 20(4), pp. 228-238. https://doi.org/10.1177/1527154419877571
Quality of life and personal resilience in the first two years after breast cancer diagnosis : Systematic integrative review
Edward, Karen-leigh, Chipman, Mitchell, Giandinoto, Jo-Ann and Robinson, Kayte. (2019). Quality of life and personal resilience in the first two years after breast cancer diagnosis : Systematic integrative review. British Journal of Nursing. 28(10), pp. S4-S14. https://doi.org/10.12968/bjon.2019.28.10.S4
Self- screening using the Edinburgh post natal depression scale for mothers and fathers to initiate early help seeking behaviours
Edward, Karen-leigh, Giandinoto, Jo-Ann, Stephenson, John, Mills, Cally, McFarland, Judelle and Castle, David J.. (2019). Self- screening using the Edinburgh post natal depression scale for mothers and fathers to initiate early help seeking behaviours. Archives of Psychiatric Nursing. 33(4), pp. 421-427. https://doi.org/10.1016/j.apnu.2019.05.007
Recovery in early stage breast cancer—An Australian longitudinal study
Edward, Karen-leigh, Chipman, Mitchell, Stephenson, John, Robinson, Kayte, Giandinoto, Jo-Ann and Trisno, Roth. (2019). Recovery in early stage breast cancer—An Australian longitudinal study. International Journal of Nursing Practice. 25(4), p. e12747. https://doi.org/10.1111/ijn.12747
The impact of brief lifestyle self-management education for the control of seizures
Edward, K., Cook, Mark, Stephenson, John and Giandinoto, Jo-Ann. (2019). The impact of brief lifestyle self-management education for the control of seizures. British Journal of Nursing. 28(6), pp. 348-354. https://doi.org/10.12968/bjon.2019.28.6.348
Dynamics of nurses' authority in the inpatient care of adolescent consumers with anorexia nervosa : A qualitative study of nursing perspectives
Zugai, Joel Sebastian, Stein-Parbury, Jane and Roche, Michael. (2019). Dynamics of nurses' authority in the inpatient care of adolescent consumers with anorexia nervosa : A qualitative study of nursing perspectives. International Journal of Mental Health Nursing. 28(4), pp. 940-949. https://doi.org/10.1111/inm.12595
Adding unregulated nursing support workers to ward staffing: Exploration of a natural experiment
Christine Duffield, Michael Roche, Di Twigg, Anne Williams, Samantha Rowbotham and Sean Clarke. (2018). Adding unregulated nursing support workers to ward staffing: Exploration of a natural experiment. Journal of Clinical Nursing. 27(19-20), pp. 3768-3779. https://doi.org/10.1111/jocn.14632
Whole body vibration exercise in the management of cancer therapy-related morbidities: A systematic review
Lopes-Souza, Patrícia, Dionello, Carla Fontoura, da Cunha Sá-Caputo, Danúbia, Moreira-Marconi, Eloá, Ferreira Frederico, Eric Heleno Freire, Marchon, Renata Marques, Bergmann, Anke, Furness, Trentham and Bernardo-Filho, Mario. (2018). Whole body vibration exercise in the management of cancer therapy-related morbidities: A systematic review. Drug Discoveries and Therapeutics. 12(4), pp. 239 - 247. https://doi.org/10.5582/ddt.2018.01039
Acute effects of whole-body vibration on the pain level, flexibility, and cardiovascular responses in individuals with metabolic syndrome
Sa-Caputo, Danubia C., Paineiras-Domingos, L. L., Oliveira, Ricardo, Neves, Mario F. T., Brandão, Andrea, Marin, Pedro J., Sañudo, Borja, Furness, Trentham, Taiar, Redha and Bernado-Filho, Mario. (2018). Acute effects of whole-body vibration on the pain level, flexibility, and cardiovascular responses in individuals with metabolic syndrome. Dose-Response: An International Journal. 16(4), pp. 1 - 9. https://doi.org/10.1177/1559325818802139
The nature of the therapeutic alliance between nurses and consumers with anorexia nervosa in the inpatient setting: A mixed‐methods study
Zugai, Joel S., Stein-Parbury, Jane and Roche, Michael. (2018). The nature of the therapeutic alliance between nurses and consumers with anorexia nervosa in the inpatient setting: A mixed‐methods study. Journal of Clinical Nursing. 27(43862), pp. 416 - 426. https://doi.org/10.1111/jocn.13944
Effect of a thermal care bundle on the prevention, detection and treatment of perioperative inadvertent hypothermia
Duff, Jed, Walker, Kim, Edward, Karen-Leigh, Ralph, Nicholas, Giandinoto, Jo-Ann, Alexander, Kimberley, Gow, Jeff and Stephenson, John. (2018). Effect of a thermal care bundle on the prevention, detection and treatment of perioperative inadvertent hypothermia. Journal of Clinical Nursing. 27(5-6), pp. 1239 - 1249. https://doi.org/10.1111/jocn.14171
Therapeutic alliance, anorexia nervosa, and the inpatient setting: A mixed methods study
Zugai, Joel S., Stein-Parbury, Jane and Roche, Michael. (2018). Therapeutic alliance, anorexia nervosa, and the inpatient setting: A mixed methods study. Journal of Advanced Nursing. 74(2), pp. 443 - 453. https://doi.org/10.1111/jan.13410
Brief interventions to de-escalate disturbances in emergency departments
Edward, Karen-leigh, Giandinoto, Jo-Ann, Weiland, Tracey J., Hutton, Jennie and Reel, Sarah. (2018). Brief interventions to de-escalate disturbances in emergency departments. British Journal of Nursing. 27(6), pp. 322 - 327. https://doi.org/10.12968/bjon.2018.27.6.322
General hospital health professionals' attitudes and perceived dangerousness towards patients with comorbid mental and physical health conditions: Systematic review and meta-analysis
Giandinoto, Jo-Ann, Stephenson, John and Edward, Karen-leigh. (2018). General hospital health professionals' attitudes and perceived dangerousness towards patients with comorbid mental and physical health conditions: Systematic review and meta-analysis. International Journal of Mental Health Nursing. 27(3), pp. 942 - 955. https://doi.org/10.1111/inm.12433
Nursing practices in Catholic healthcare: A case study of nurses in a Catholic private hospital
Edward, Karen-leigh, Giandinoto, Jo-Ann, Mills, Cally and Kay, Kate. (2018). Nursing practices in Catholic healthcare: A case study of nurses in a Catholic private hospital. Journal of Religion and Health. 57(5), pp. 1664 - 1678. https://doi.org/10.1007/s10943-017-0520-z
When parenting does not 'come naturally': Providers' perspectives on parenting education for incarcerated mothers and fathers
Fowler, Cathrine M., Dawson, Angela J., Rossiter, Chris, Jackson, Debra, Power, Tamara and Roche, Michael. (2018). When parenting does not 'come naturally': Providers' perspectives on parenting education for incarcerated mothers and fathers. Studies in Continuing Education. 40(1), pp. 98 - 114. https://doi.org/10.1080/0158037X.2017.1396449
Clinical approaches of whole body vibration exercises in individuals with stroke: A narrative revision
Sañudo, Borja, Taiar, Redha, Furness, Trentham and Bernardo-Filho, Mario. (2018). Clinical approaches of whole body vibration exercises in individuals with stroke: A narrative revision. Rehabilitation Research and Practice. 2018, pp. 1 - 8. https://doi.org/10.1155/2018/8180901
Nursing and focal dyscognitive seizures: A clinical update when managing risk using advanced nursing skills
Holland, Christine, Edward, Karen-Leigh and Giandinoto, Jo-Ann. (2017). Nursing and focal dyscognitive seizures: A clinical update when managing risk using advanced nursing skills. Journal of Neuroscience Nursing. 49(3), pp. 164-168. https://doi.org/10.1097/JNN.0000000000000276
User compliance with documenting on a track and trigger-based observation and response chart: A two-phase multi-site audit study
Elliott, Doug, Allen, Emily, McKinley, Sharon, Perry, Lin, Duffield, Christine, Fry, Margaret, Gallagher, Robyn, Iedema, Rick and Roche, Michael. (2017). User compliance with documenting on a track and trigger-based observation and response chart: A two-phase multi-site audit study. Journal of Advanced Nursing. 73(12), pp. 2892 - 2902. https://doi.org/10.1111/jan.13302
A comparison of nursing tasks undertaken by regulated nurses and nursing support workers: A work sampling study
Roche, Michael A., Friedman, Sarah, Duffield, Christine, Twigg, Diane E. and Cook, Rebecca. (2017). A comparison of nursing tasks undertaken by regulated nurses and nursing support workers: A work sampling study. Journal of Advanced Nursing. 73(6), pp. 1421 - 1432. https://doi.org/10.1111/jan.13224
Personal descriptions of life before and after bariatric surgery from overweight or obese men
Leigh-Edward, Karen, Mrcna, Facmhn, Hii, Michael, Giandinoto, Jo-Ann, Hennessy, Julia and Thompson, Lisa. (2017). Personal descriptions of life before and after bariatric surgery from overweight or obese men. American Journal of Men's Health. 12(2), pp. 265 - 273. https://doi.org/10.1177/1557988316630770
Adding an accredited exercise physiologist role to a new model of care at a secure extended care mental health service: a qualitative study
Furness, Trentham, Hewavasam, Jude, Barnfield, Jacqui, McKenna, Brian and Joseph, Corey. (2017). Adding an accredited exercise physiologist role to a new model of care at a secure extended care mental health service: a qualitative study. Journal of Mental Health. 27(2), pp. 120 - 126. https://doi.org/10.1080/09638237.2017.1294744
The impact of evidence-based sepsis guidelines on emergency department clinical practice: A pre-post medical record audit
Romero, Bernadine, Fry, Margaret and Roche, Michael. (2017). The impact of evidence-based sepsis guidelines on emergency department clinical practice: A pre-post medical record audit. Journal of Clinical Nursing. 26(21-22), pp. 3588 - 3596. https://doi.org/10.1111/jocn.13728
Intrahospital transfers and the impact on nursing workload
Blay, Nicole, Roche, Michael A., Duffield, Christine and Gallagher, Robyn. (2017). Intrahospital transfers and the impact on nursing workload. Journal of Clinical Nursing. 26(23-24), pp. 4822 - 4829. https://doi.org/10.1111/jocn.13838
Impact of a nurse practitioner role on metabolic monitoring completion and referrals for consumers admitted to the intensive care area of an acute inpatient psychiatric unit
Brown, Trudy, McKenna, Brian and Furness, Trentham. (2017). Impact of a nurse practitioner role on metabolic monitoring completion and referrals for consumers admitted to the intensive care area of an acute inpatient psychiatric unit. International Journal of Mental Health Nursing. 27, pp. 341 - 348. https://doi.org/10.1111/inm.12327
Prolonged use of seclusion and mechanical restraint in mental health services: A statewide retrospective cohort study
McKenna, Brian, McEvedy, Samantha, Maguire, Tessa, Ryan, Jo and Furness, Trentham. (2017). Prolonged use of seclusion and mechanical restraint in mental health services: A statewide retrospective cohort study. International Journal of Mental Health Nursing. https://doi.org/10.1111/inm.12383
Are new nurses work ready - The impact of preceptorship: An integrative systematic review
Edward, Karen-Leigh, Ousey, Karen, Playle, John and Giandinoto, Jo-Ann. (2017). Are new nurses work ready - The impact of preceptorship: An integrative systematic review. Journal of Professional Nursing. 33(5), pp. 326 - 333. https://doi.org/10.1016/j.profnurs.2017.03.003
Post-fall reporting in aged acute inpatient mental health units: an 18-month observational cohort study
Furness, Trentham, Mnatzaganian, George, Garlick, Robyn, Ireland, Susan, McKenna, Brian and Hill, Keith. (2017). Post-fall reporting in aged acute inpatient mental health units: an 18-month observational cohort study. International Psychogeriatrics. 29(12), pp. 2007 - 2016. https://doi.org/10.1017/S1041610217001648
Perceptions of procedural justice and coercion during community-based mental health crisis: a comparison study among stand-alone police response and co-responding police and mental health clinician response
Furness, Trentham, Maguire, Tessa, Brown, Steve and McKenna, Brian. (2017). Perceptions of procedural justice and coercion during community-based mental health crisis: a comparison study among stand-alone police response and co-responding police and mental health clinician response. Policing (Oxford): a journal of policy and practice. 11(4), pp. 400 - 409. https://doi.org/10.1093/police/paw047
Emotional labour in mental health nursing: An integrative systematic review
Edward, Karen-Leigh, Hercelinskyj, Gylo and Giandinoto, Jo-Ann. (2017). Emotional labour in mental health nursing: An integrative systematic review. International Journal of Mental Health Nursing. 26(3), pp. 215 - 225. https://doi.org/10.1111/inm.12330
Sensory modulation and trauma-informed-care knowledge transfer and translation in mental health services in Victoria: Evaluation of a statewide train-the-trainer intervention
McEvedy, Samantha, Maguire, Tessa, Furness, Trentham and McKenna, Brian. (2017). Sensory modulation and trauma-informed-care knowledge transfer and translation in mental health services in Victoria: Evaluation of a statewide train-the-trainer intervention. Nurse Education in Practice. 25, pp. 36 - 42. https://doi.org/10.1016/j.nepr.2017.04.012
Intrahospital transfers and adverse patient outcomes: An analysis of administrative health data
Blay, Nicole, Roche, Michael, Duffield, Christine and Xu, Xiaoyue. (2017). Intrahospital transfers and adverse patient outcomes: An analysis of administrative health data. Journal of Clinical Nursing. 26(23-24), pp. 4927 - 4935. https://doi.org/10.1111/jocn.13976
Learning to become a better man: Insights from a prison fathering program for incarcerated Indigenous men
Rossiter, Chris, Power, Tamara, Fowler, Cathrine, Jackson, Debra, Roche, Michael and Dawson, Angela. (2017). Learning to become a better man: Insights from a prison fathering program for incarcerated Indigenous men. Australian Journal of Social Issues. 52(1), pp. 13 - 31. https://doi.org/10.1002/ajs4.4
Analysis of the experiences of nurses who return to nursing after cancer
Edward, Karen-Leigh, Giandinoto, Jo-Ann and McFarland, Judelle. (2017). Analysis of the experiences of nurses who return to nursing after cancer. British Journal of Nursing. 26(21), pp. 1170 - 1175. https://doi.org/10.12968/bjon.2017.26.21.1170
Workforce flexibility: In defence of professional healthcare work
Wise, Sarah, Duffield, Christine, Fry, Margaret and Roche, Michael. (2017). Workforce flexibility: In defence of professional healthcare work. Journal of Health, Organization and Management. 31(4), pp. 503 - 516. https://doi.org/10.1108/JHOM-01-2017-0009
Association of methamphetamine use and restrictive interventions in an acute adult inpatient mental health unit: A retrospective cohort study
McKenna, Brian, McEvedy, Sam, Kelly, Kathleen, Long, Bec, Anderson, Jess, Dalzell, Elaine, Maguire, Tessa, Tacey, Mark and Furness, Trentham. (2017). Association of methamphetamine use and restrictive interventions in an acute adult inpatient mental health unit: A retrospective cohort study. International Journal of Mental Health Nursing. 26(1), pp. 49 - 55. https://doi.org/10.1111/inm.12283
A systematic literature review of accuracy in nursing care plans and using standardised nursing language
Johnson, Linden, Edward, Karen-Leigh and Giandinoto, Jo-Ann. (2017). A systematic literature review of accuracy in nursing care plans and using standardised nursing language. Collegian. 25(3), pp. 355 - 361. https://doi.org/10.1016/j.colegn.2017.09.006
Introduction of a drug-detection dog programme in mental health inpatient units: A mixed-methods study of consumer, staff, and carers' perceptions
McEvedy, Samantha, Furness, Trentham and McKenna, Brian. (2017). Introduction of a drug-detection dog programme in mental health inpatient units: A mixed-methods study of consumer, staff, and carers' perceptions. International Journal of Mental Health Nursing. 27, pp. 408 - 421. https://doi.org/10.1111/inm.12335
Recovery-oriented mental health practice in a community care unit: An exploratory study
McKenna, Brian, Oakes, Jane, Fourniotis, Niki, Toomey, Nigel and Furness, Trentham. (2016). Recovery-oriented mental health practice in a community care unit: An exploratory study. Journal of Forensic Nursing. 12(4), pp. 167-175. https://doi.org/10.1097/JFN.0000000000000127
Regulated and unregulated nurses in the acute hospital setting: Tasks performed, delayed or not completed
Roche, Michael Anthony, Duffield, Christine and Friedman, Sarah. (2016). Regulated and unregulated nurses in the acute hospital setting: Tasks performed, delayed or not completed. Journal of Clinical Nursing. 25(1-2), pp. 153 - 162. https://doi.org/10.1111/jocn.13118
A protocol to assess the impact of adding nursing support workers to ward staffing
Duffield, Christine, Roche, Michael Anthony, Twigg, Di, Williams, Anne and Clarke, Sean. (2016). A protocol to assess the impact of adding nursing support workers to ward staffing. Journal of Advanced Nursing. 72(9), pp. 2218 - 2225. https://doi.org/10.1111/jan.12965
The impact of adding assistants in nursing to acute care hospital ward nurse staffing on adverse patient outcomes: An analysis of administrative health data
Twigg, Diane E., Myers, Helen, Duffield, Christine, Pugh, Judith D., Gelder, Lucy and Roche, Michael Anthony. (2016). The impact of adding assistants in nursing to acute care hospital ward nurse staffing on adverse patient outcomes: An analysis of administrative health data. International Journal of Nursing Studies. 63(November), pp. 189 - 200. https://doi.org/10.1016/j.ijnurstu.2016.09.008
An Australian longitudinal pilot study examining health determinants of cardiac outcomes 12 months post percutaneous coronary intervention
Edward, Karen-Leigh, Stephenson, John, Giandinoto, Jo-Ann M., Wilson, Andrew, Whitbourn, Robert, Gutman, Jack and Newcomb, Andrew. (2016). An Australian longitudinal pilot study examining health determinants of cardiac outcomes 12 months post percutaneous coronary intervention. BMC Cardiovascular Disorders. 16(31), pp. 1 - 8. https://doi.org/10.1186/s12872-016-0203-9
Point-of-care testing of activated clotting time in the ICU: Is it relevant?
Brown, Ellenora, Clarke, Jody, Edward, Karen-Leigh and Giandinoto, Jo-Ann Michelle. (2016). Point-of-care testing of activated clotting time in the ICU: Is it relevant? British Journal of Nursing. 25(11), pp. 608 - 612. https://doi.org/10.12968/bjon.2016.25.11.608
Changes to nurses' practice environment over time
Roche, Michael Anthony, Duffield, Christine, Friedman, Sarah and Twigg, Di. (2016). Changes to nurses' practice environment over time. Journal of Nursing Management. 24(5), pp. 666 - 675. https://doi.org/10.1111/jonm.12371
A systematic review and meta-analysis of factors that relate to aggression perpetrated against nurses by patients/relatives or staff
Edward, Karen-Leigh, Stephenson, John, Ousey, Karen, Lui, Steve, Warelow, Philip and Giandinoto, Jo-Ann Michelle. (2016). A systematic review and meta-analysis of factors that relate to aggression perpetrated against nurses by patients/relatives or staff. Journal of Clinical Nursing. 25(3-4), pp. 289 - 299. https://doi.org/10.1111/jocn.13019
The experience of mental health literacy in health professionals in non-mental health areas
Giandinoto, Jo-Ann and Edward, Karen-Leigh. (2016). The experience of mental health literacy in health professionals in non-mental health areas. The International Journal of Health, Wellness and Society. 6(2), pp. 1 - 13.
Educating Mental Health Clinicians About Sensory Modulation to Enhance Clinical Practice in a Youth Acute Inpatient Mental Health Unit: A Feasibility Study
Blackburn, Julie, McKenna, Brian, Jackson, Brian, Hitch, Danielle, Benitez, Jessica and Furness, Trentham. (2016). Educating Mental Health Clinicians About Sensory Modulation to Enhance Clinical Practice in a Youth Acute Inpatient Mental Health Unit: A Feasibility Study. Issues in Mental Health Nursing. https://doi.org/10.1080/01612840.2016.1184361
Tai chi for schizophrenia (protocol)
Liu, Yan, Bo, Li, Furness, Trentham, Xia, Jun, Joseph, Corey W. J., Tang, Xudong, Zheng, Jingchen and Wang, Zhenfu. (2015). Tai chi for schizophrenia (protocol). Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD011473
A brief report on the development of a theoretically-grounded intervention to promote patient autonomy and self-management of physiotherapy patients: Face validity and feasibility of implementation
Matthews, Karen-Leigh, Cook, Mark and Giandinoto, Jo-Ann. (2015). A brief report on the development of a theoretically-grounded intervention to promote patient autonomy and self-management of physiotherapy patients: Face validity and feasibility of implementation. BMC Health Services Research. 15(260), pp. 1 - 9. https://doi.org/10.1186/s12913-015-0921-1
Police and clinician diversion of people in mental health crisis from the Emergency Department: A trend analysis and cross comparison study
McKenna, Brian, Furness, Trentham, Brown, Steve, Tacey, Mark, Hiam, Andrew and Wise, Morgan. (2015). Police and clinician diversion of people in mental health crisis from the Emergency Department: A trend analysis and cross comparison study. BMC Emergency Medicine. 15(1), pp. 1 - 6. https://doi.org/10.1186/s12873-015-0040-7
Testing the nursing worklife model in Canada and Australia: A multi-group comparison study
Roche, Michael Anthony, Spence Laschinger, Heather K. and Duffield, Christine. (2015). Testing the nursing worklife model in Canada and Australia: A multi-group comparison study. International Journal of Nursing Studies. 52(2), pp. 525 - 534. https://doi.org/10.1016/j.ijnurstu.2014.10.016
Nurses' perspectives of the impact of the older person on nursing resources in the emergency department and their profile: A mixed methods study
Gallagher, Robyn, Gallagher, Peter, Roche, Michael Anthony and Fry, Margaret. (2015). Nurses' perspectives of the impact of the older person on nursing resources in the emergency department and their profile: A mixed methods study. International emergency nursing. 23(4), pp. 312 - 316. https://doi.org/10.1016/j.ienj.2015.03.006
Therapeutic alliance in mental health nursing: An evolutionary concept analysis
Zugai, Joel Sebastian, Stein-Parbury, Jane and Roche, Michael Anthony. (2015). Therapeutic alliance in mental health nursing: An evolutionary concept analysis. Issues in Mental Health Nursing. 36(4), pp. 249 - 257. https://doi.org/10.3109/01612840.2014.969795
The phenomenon of co-morbid physical and mental illness in acute medical care: The lived experience of Australian health professionals
Giandinoto, Jo-Ann and Edward, Karen-leigh. (2015). The phenomenon of co-morbid physical and mental illness in acute medical care: The lived experience of Australian health professionals. BMC Research Notes. 8(1), pp. 1 - 9. https://doi.org/10.1186/s13104-015-1264-z
Applying the World Health Organization Mental Health Action Plan to evaluate policy on addressing co-occurrence of physical and mental illnesses in Australia
Happell, Brenda, Platania-Phung, Chris, Webster, Stephanie, McKenna, Brian, Millar, Freyja, Stanton, Robert, Galletly, Cherrie, Castle, David, Furness, Trentham, Liu, Dennis and Scott, David. (2015). Applying the World Health Organization Mental Health Action Plan to evaluate policy on addressing co-occurrence of physical and mental illnesses in Australia. Australian Health Review. 39(4), pp. 370 - 378. https://doi.org/10.1071/AH14098
Mock admissions used to minimise paediatric anxiety before surgery
Edward, Karen-Leigh, Sanderson, Wendy and Giandinoto, Jo-Ann Michelle. (2015). Mock admissions used to minimise paediatric anxiety before surgery. ACORN : The Journal of Perioperative Nursing in Australia. 28(4), pp. 24 - 26.
Instability in patient and nurse characteristics, unit complexity and patient and system outcomes
Duffield, Christine M., Roche, Michael Anthony, Dimitrelis, Sofia and Homer, Caroline S.. (2015). Instability in patient and nurse characteristics, unit complexity and patient and system outcomes. Journal of Advanced Nursing. 71(6), pp. 1288 - 1298. https://doi.org/10.1111/jan.12597
The rate and cost of nurse turnover in Australia
Roche, Michael Anthony, Duffield, Christine M., Homer, Caroline S. and Buchan, James. (2015). The rate and cost of nurse turnover in Australia. Collegian. 22(4), pp. 353 - 358. https://doi.org/10.1016/j.colegn.2014.05.002
The effectiveness of specialist roles in mental health metabolic monitoring: A retrospective cross-sectional comparison study
McKenna, Brian, Furness, Trentham, Wallace, Elizabeth, Happell, Brenda, Stanton, Robert, Platania-Phung, Chris, Edward, Karen-Leigh and Castle, David. (2014). The effectiveness of specialist roles in mental health metabolic monitoring: A retrospective cross-sectional comparison study. BMC Psychiatry. 14(234), pp. 1 - 6. https://doi.org/10.1186/s12888-014-0234-7
Recovery-oriented Care in Acute Inpatient Mental Health Settings : An Exploratory Study
McKenna, Brian, Furness, Trentham, Dhital, Deepa, Ennis, Garry, Houghton, James, Lupson, Christine and Toomey, Nigel. (2014). Recovery-oriented Care in Acute Inpatient Mental Health Settings : An Exploratory Study. Issues in Mental Health Nursing. 35(7), pp. 526 - 532. https://doi.org/10.3109/01612840.2014.890684
A comparative review of nurse turnover rates and costs across countries
Duffield, Christine M., Roche, Michael Anthony, Homer, Caroline S., Buchan, James and Dimitrelis, Sofia. (2014). A comparative review of nurse turnover rates and costs across countries. Journal of Advanced Nursing. 70(12), pp. 2703 - 2712. https://doi.org/10.1111/jan.12483
Benefits of whole-body vibration to people with COPD: a community-based efficacy trial
Furness, Trentham, Joseph, Corey, Naughton, Geraldine, Welsh, Liam and Lorenzen, Christian. (2014). Benefits of whole-body vibration to people with COPD: a community-based efficacy trial. BMC Pulmonary Medicine. 14(1), pp. 1 - 7. https://doi.org/10.1186/1471-2466-14-38
The use of unregulated staff: Time for regulation?
Duffield, Christine M., Twigg, Di E., Pugh, Judith D., Evans, Gemma, Dimitrelis, Sofia and Roche, Michael Anthony. (2014). The use of unregulated staff: Time for regulation? Policy Politics and Nursing Practice. 15(1-2), pp. 42 - 48. https://doi.org/10.1177/1527154414529337
Furness, Trentham, Joseph, Corey, Naughton, Geraldine, Welsh, Liam and Lorenzen, Christian. (2014). Benefits of whole-body vibration to people with COPD: A community-based efficacy trial. BMC Pulmonary Medicine. 14(38), pp. 1 - 7. https://doi.org/10.1186/1471-2466-14-38
Challenges in acute care of people with co-morbid mental illness
Giandinoto, Jo-Ann and Edward, Karen-Leigh. (2014). Challenges in acute care of people with co-morbid mental illness. British Journal of Nursing. 23(13), pp. 728 - 732. https://doi.org/10.12968/bjon.2014.23.13.728
The transformation from custodial to recovery-oriented care : A paradigm shift that needed to happen
McKenna, Brian, Furness, Trentham, Dhital, Deepa, Park, Malcolm and Connally, Fiona. (2014). The transformation from custodial to recovery-oriented care : A paradigm shift that needed to happen. Journal of Forensic Nursing. 10(4), pp. 226 - 233. https://doi.org/10.1097/JFN.0000000000000045
Disparities in treatment of people with mental disorder in non-psychiatric hospitals: A review of the literature
Mather, Brad and Roche, Michael Anthony. (2014). Disparities in treatment of people with mental disorder in non-psychiatric hospitals: A review of the literature. Archives of Psychiatric Nursing. 28(2), pp. 80 - 86. https://doi.org/10.1016/j.apnu.2013.10.009
When reduction strategies are put into place and mental health consumers are still secluded : An analysis of clinical and sociodemographic characteristics
Bullock, Rebecca, McKenna, Brian, Kelly, Teresa, Furness, Trentham and Tacey, Mark. (2014). When reduction strategies are put into place and mental health consumers are still secluded : An analysis of clinical and sociodemographic characteristics. International Journal of Mental Health Nursing. 23(6), pp. 506 - 512. https://doi.org/10.1111/inm.12078
The relationship between social media, depression prevention and support for women postnatally
Edward, Karen-Leigh, Smith, Ken, McFarland, Judelle, Olorenshaw, Jody, Turner, Liz, Hewett, Clare and Giandinoto, Jo-Ann. (2014). The relationship between social media, depression prevention and support for women postnatally. In P. Moris (Ed.). 15th International Mental Health Conference. Mental Health: Innovation, Integration, Early Intervention. Australia: Australian and New Zealth Mental Health Association. pp. 31 - 45
Using the team to reduce risk of blood and body fluid exposure in the perioperative setting
Moore, Carolyn, Edward, Karen-Leigh, King, Karolin and Giandinoto, Jo-Ann. (2014). Using the team to reduce risk of blood and body fluid exposure in the perioperative setting. ACORN : The Journal of Perioperative Nursing in Australia. 27(3), pp. 8 - 14.
The PICHFORK (Pain InCHildren Fentanyl OR Ketamine) trial comparing the efficacy of intranasal ketamine and fentanyl in the relief of moderate to severe pain in children with limb injuries : study protocol for a randomized controlled trial
Graudins, Andis, Meek, Robert, Egerton-Warburton, Diana, Seith, Robert, Furness, Trentham and Chapman, Rosemary. (2013). The PICHFORK (Pain InCHildren Fentanyl OR Ketamine) trial comparing the efficacy of intranasal ketamine and fentanyl in the relief of moderate to severe pain in children with limb injuries : study protocol for a randomized controlled trial. Trials. https://doi.org/10.1186/1745-6215-14-208
A four month prospective descriptive exploratory study of patients receiving antibiotics in one Emergency Department
Fry, Margaret, Horvat, Leanne and Roche, Michael Anthony. (2013). A four month prospective descriptive exploratory study of patients receiving antibiotics in one Emergency Department. International emergency nursing. 21(3), pp. 163 - 167. https://doi.org/10.1016/j.ienj.2012.07.004
Whole-body vibration as a mode of dyspnoea free physical activity: a community-based proof-of-concept trial
Furness, Trentham, Joseph, Corey, Welsh, Liam, Naughton, Geraldine and Lorenzen, Christian. (2013). Whole-body vibration as a mode of dyspnoea free physical activity: a community-based proof-of-concept trial. BMC Research Notes. 6(452), pp. 1 - 4. https://doi.org/10.1186/1756-0500-6-452
Domains of practice and advanced practice nursing in Australia
Roche, Michael Anthony and Duffield, Christine. (2013). Domains of practice and advanced practice nursing in Australia. Nursing and Health Sciences. 15(4), pp. 497 - 503. https://doi.org/10.1111/nhs.12062
Efficacy of a whole-body vibration intervention to effect exercise tolerance and functional performance of the lower limbs of people with chronic obstructive pulmonary disease
Furness, Trentham, Bate, Nicole, Welsh, Liam, Naughton, Geraldine and Lorenzen, Christian. (2012). Efficacy of a whole-body vibration intervention to effect exercise tolerance and functional performance of the lower limbs of people with chronic obstructive pulmonary disease. BMC Pulmonary Medicine. 12(71), pp. 1 - 6. https://doi.org/10.1186/1471-2466-12-71
Nursing work directions in Australia: Does evidence drive the policy?
Roche, Michael Anthony and Duffield, Christine. (2012). Nursing work directions in Australia: Does evidence drive the policy? Collegian. 19(4), pp. 231 - 238. https://doi.org/10.1016/j.colegn.2012.03.006
The prevalence and triage characteristics of patients presenting with infection to one tertiary referral hospital
Fry, Margaret, Horvat, Leanne and Roche, Michael Anthony. (2012). The prevalence and triage characteristics of patients presenting with infection to one tertiary referral hospital. Australasian Emergency Nursing Journal. 15(3), pp. 127 - 132. https://doi.org/10.1016/j.aenj.2012.06.001
Effect of performance jewlery on balance of elite Australian rules footballers and healthy young adults
Joseph, Corey, Furness, Trentham, Buttifant, David and Naughton, Geraldine. (2012). Effect of performance jewlery on balance of elite Australian rules footballers and healthy young adults. In E J Bradshaw, A Burnett and P A Hume (Ed.). 30th Conference of the International Society of Biomechanics in Sports. Australia: International Society of Biomechanics. pp. 162 - 165
Nursing unit managers, staff retention and the work environment
Duffield, Christine M. and Roche, Michael Anthony. (2011). Nursing unit managers, staff retention and the work environment. Journal of Clinical Nursing. 20(1-2), pp. 23 - 33. https://doi.org/10.1111/j.1365-2702.2010.03478.x
Factors in the practice environment of nurses working in inpatient mental health: A partial least squares path modeling approach
Roche, Michael Anthony, Duffield, Christine and White, Edward. (2011). Factors in the practice environment of nurses working in inpatient mental health: A partial least squares path modeling approach. International Journal of Nursing Studies. 48(12), pp. 1475 - 1486. https://doi.org/10.1016/j.ijnurstu.2011.07.001
The consequences of executive turnover
Duffield, Christine and Roche, Michael Anthony. (2011). The consequences of executive turnover. Journal of Research in Nursing. 16(6), pp. 503 - 514. https://doi.org/10.1177/1744987111422419
Efficacy of a whole-body vibration intervention on functional performance of community-dwelling older adults
Furness, Trentham, Maschette, Wayne, Lorenzen, Christian, Naughton, Geraldine and Williams, Morgan. (2010). Efficacy of a whole-body vibration intervention on functional performance of community-dwelling older adults. Journal of Alternative & Complementary Medicine. 16(7), pp. 795 - 797. https://doi.org/10.1089/acm.2009.0366
A comparison of the nursing practice environment in mental health and medical-surgical settings
Roche, Michael and Duffield, Christine. (2010). A comparison of the nursing practice environment in mental health and medical-surgical settings. Journal of Nursing Scholarship. 42(2), pp. 195 - 206. https://doi.org/10.1111/j.1547-5069.2010.01348.x
Staffing, skill mix and the model of care
Duffield, Christine, Roche, Michael, Diers, Donna, Catling-Paull, Christine and Blay, Nicole. (2010). Staffing, skill mix and the model of care. Journal of Clinical Nursing. 19(15-16), pp. 2242 - 2251. https://doi.org/10.1111/j.1365-2702.2010.03225.x
Violence toward nurses, the work environment, and patient outcomes
Roche, Michael, Diers, Donna, Duffield, Christine and Catling-Paull, Christine. (2010). Violence toward nurses, the work environment, and patient outcomes. Journal of Nursing Scholarship. 42(1), pp. 13 - 22. https://doi.org/10.1111/j.1547-5069.2009.01321.x
Staff satisfaction and retention and the role of the Nursing Unit Manager
Duffield, Christine, Roche, Michael, Pallas, Linda O'Brien, Catling-Paull, Christine and King, Madeleine. (2009). Staff satisfaction and retention and the role of the Nursing Unit Manager. Collegian. 16(1), pp. 11 - 17. https://doi.org/10.1016/j.colegn.2008.12.004
The implications of staff 'churn' for nurse managers, staff, and patients
Duffield, Christine, Roche, Michael, O'Brien Pallas, Linda and Catling-Paull, Christine. (2009). The implications of staff 'churn' for nurse managers, staff, and patients. Nursing Economics.
Churn: Patient turnover and mix
Duffield, Christine, Diers, Donna, Aisbett, Chris and Roche, Michael. (2009). Churn: Patient turnover and mix. Nursing Economics.
Issues and challenges in the mental health workforce development
Roche, Michael and Duffield, Christine. (2007). Issues and challenges in the mental health workforce development. Contemporary Nurse. 25(43862), pp. 94 - 103. https://doi.org/10.5172/conu.2007.25.1-2.94
A selective review of mental health nursing in New South Wales, Australia, in relation to clinical supervision
White, Edward and Roche, Michael. (2006). A selective review of mental health nursing in New South Wales, Australia, in relation to clinical supervision. International Journal of Mental Health Nursing. 15(3), pp. 209 - 219. https://doi.org/10.1111/j.1447-0349.2006.00424.x
Methods of measuring nursing workload in Australia.
Duffield, Christine, Roche, Michael and Merrick, Eamon Thomas. (2006). Methods of measuring nursing workload in Australia. Collegian. 13(1), pp. 16 - 22. https://doi.org/10.1016/S1322-7696(08)60512-0
Recruitment of nurses working outside nursing
Duffield, Christine, Pallas, Linda O'Brien, Aitken, Leanne M., Roche, Michael and Merrick, Eamon Thomas. (2006). Recruitment of nurses working outside nursing. Journal of Nursing Administration. 36(2), pp. 58 - 62. https://doi.org/10.1097/00005110-200602000-00002


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Beast by Brie Spangler
October 17, 2016 by Jaime Leave a Comment
We are so excited to be a part of the tour for BEAST by Brie Spangler today! We have an interview with Brie coming up, but first, here are the details:
Published by Random House Children's Books on October 11th 2016
Genres: Dating & Sex, General, Humorous, LGBT, Social Themes, Young Adult Fiction
Tall, meaty, muscle-bound, and hairier than most throw rugs, Dylan doesn't look like your average fifteen-year-old, so, naturally, high school has not been kind to him. To make matters worse, on the day his school bans hats (his preferred camouflage), Dylan goes up on his roof only to fall and wake up in the hospital with a broken leg—and a mandate to attend group therapy for self-harmers.
Dylan vows to say nothing and zones out at therapy—until he meets Jamie. She's funny, smart, and so stunning, even his womanizing best friend, JP, would be jealous. She's also the first person to ever call Dylan out on his self-pitying and superficiality. As Jamie's humanity and wisdom begin to rub off on Dylan, they become more than just friends. But there is something Dylan doesn't know about Jamie, something she shared with the group the day he wasn't listening. Something that shouldn't change a thing. She is who she's always been—an amazing photographer and devoted friend, who also happens to be transgender. But will Dylan see it that way?
Describe BEAST in 5 words.
Rage. Hope. Bitter. Sweet. Love.
How did BEAST come about, what was your inspiration? What made you think you had to write this story?
I just really wanted to write a love story! If I have to nail it down to two factors, would have to say the New England Patriots and Disney. I grew up next door to Gillette Stadium and it wasn't uncommon to see the players milling about at the grocery store, the bowling alley, and of course, the all you can eat buffet. It's one thing to see these guys on TV, but when you see them in person, it's just like omg I can barely imagine a human body being that large, especially when you're a kid and you're still growing too. In addition to the Patriots, I was a huge, big, enormous fan of Disney's Beauty and the Beast when I was young, so that's honestly all it took to light the flames. Once I met Jamie and Dylan, they carried the book through. I won't say it was easy because writing can be the worst pain in the rear ever, but I could write about these two forever and that's what made it fun.
What was the hardest scene for you to write in BEAST and why?
Anytime transphobia entered the discussion, it was very hard to write. I want a world where transphobia doesn't exist but unfortunately we're not there yet. Describing other peoples' transphobia towards Jamie was repulsive.
Can you share (without spoilers) a line or section of BEAST that is your favorite?
"I am that monster under the bridge. I will eat your children."
Since we're talking 2016 books, what upcoming 2016 release (besides your own) are you most excited to read and fangirl over?
Just one?? Ahhhh!! I loved so many and will love so many more! HOW IT ENDS by Catherine Lo already came out but I loved it. I'm still reading books that are already out but on my near releases list I've got WHEN THE MOON WAS OURS, LAST SEEN LEAVING, INTO WHITE, STILL LIFE WITH TORNADO, LUCY AND LINH… the list goes on and rightly so, there's so many great books out there. 2016 was a great year and 2017 is looking super hot too!
When you're not writing, what do you enjoy doing in your spare time?
I'm a total nerd, I just hang around at home with my family and friends. Love to sew and make little kitschy things and veg out watching TV while I surf the internet. #winning
Currently reading AS I DESCENDED by Robin Talley and it's bloody good fun.
Any advice for aspiring writers?
Keep writing! I know when you've been trying so hard for so long and you get rejections every day and nothing seems to be going well and everyone around you has these skyrocketing careers and all seems lost… keep writing. If you believe in your stories then we will too.
What's next for you? Are you working on anything right now that you can tell us about?
I am working and writing new YA and it's very personal to me. Going to go into a subject that has affected my life once and forever: ballet.
Favorite Song (right now): Closer by The Chainsmokers
Favorite TV Show/Movie: Breaking Bad/Goodfellas
Favorite Color: Green
Favorite Curse Word: the granddaddy of them all, of course: FUCK! 🙂
Cover Reveal: This Is Forever
BE WITH ME 5 CHAPTER REVEAL by Jennifer Armentrout
Wink Poppy Midnight by April Genevieve Tucholke
Review: Midnight Reckoning
Review: The Reece Malcolm List
Blog Tour: Hero At The Fall by Alwyn Hamilton
Waiting on Wednesday: The Love Interest by Cale Dietrich
The Beholder by Anna Bright
House of Salt and Sorrows by Erin A. Craig
Royally Matched by Emma Chase
Filed Under: Blog Tour, Book Promo, Book Review, Interview


Mount Langya which situated at Yi County of Hebei Province is one of the national forest conservation areas throughout China. Besides that, this is also the venue where the well known tragedy of Five Heroes of Mount Langya occurred. While having breathtaking scenery as well as enriched with deep cultural atmosphere, Mount Langya is welcoming each and every guest in its very unique way.
Mount Langya Scenic Area is strategically located within Baoding Town which is about 50 kilometers away from Yi County. As the mountains within the scenic area look exactly like the teeth of wolf, thus it is named as Mount Langya which literally means Wolf's Teeth Mountain. Besides being one of the top ten most attractive scenic spot of Yi County, it is also the province-based conservation forest.
Mount Langya is made up of 36 peaks that divided naturally in five groups. Lianhuaban (Lotus Petal Peak) as the main peak of Mount Langya is perched 1105 meters above sea level with steep cliffs on both northern and western side of the mountain. Due to this unique natural topography, tourists can reach the peak through the lanes on either eastern or southern part only. However, there are some narrow points along the lanes that you might need to pass through with your body stick onto the mountain too. When you reach the peak, you will find as if standing on top of the world and surrounded by uncountable sharp wolf's teeth.


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PETER WALPOLE
PETER WALPOLE - PRODUCTION DESIGNER
Production Designer Peter Walpole was originally known as one of the UK's most respected and sought-after Set Decorators. He has worked with many notable Directors, but it is his collaboration with Lana & Lilly Wachowski on nine separate projects, starting as Set Decorator, Supervising Art Director and moving to Production Designer, that he is most proud of.
Peter production designed Sense8: The Finale ("Amor Vincit Omnia") as a two-and-a-half hour movie and a closure to the popular TV series. It was shot in Naples, Paris, Belgium and Berlin, directed by Lana Wachowski and produced by Grant Hill.
Peter has worked in over 30 countries across the globe from England to Australia, on such films including Star Wars, A Phantom Menace & Attack of the Clones, Alien Vs Predator, V for Vendetta, Speed Racer, Cloud Atlas, Jason Bourne and the highly acclaimed Netflix television series Sense8.
Recently, Peter was hired as the Production Designer on the Amazon/Amblin project, Cortés, which was set in 1520. After six months of intensive research, set designs and location scouting in and around Mexico City, the project was put on hold.
Peter was then available to continue his collaboration with Lana Wachowski on the The Matrix 4. As the co-Production Designer, he has spent 18 months designing and shooting in San Francisco and Berlin.
Peter won the Best Production Design for Sense8 – The Finale from the British Film Designs Guild. He has also been nominated for an Emmy for his work on Dinatopia and received a nomination from the Art Directors Guild (ADG) for his work on Cloud Atlas.
Peter Walpole 2021
British Film Designers Guild Winner - Best Production Design, International TV Drama for Sense8 Finalé
'Prime Time Emmy' for Dinotopia [Outstanding Art Direction for a Mini Series] in 2002.
'The Art Directors Guild of America' [Excellence in Production Design] for Cloud Atlas 2013.
OVERSEAS LOCATION WORK
Finland, France, Netherlands, Czech Republic, Venice, Italy, Turkey, Prague, Thailand, Morocco, Tunisia, Ireland, Philippines, South Africa, Australia, Mallorca, Malta, Romania, Latvia, Germany, Spain, Tenerife, Hungary, Iceland, South Korea, India, Mexico, Kenya and the United States of America.
pbwalpole@aol.com


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I dated David Dontoh because lesbians pursued me for homosexual activities - Maame Dokono
By: Nana
Maame Dokono and David Dontoh
Veteran Ghanaian actress, Grace Omaboe, popularly known as Maame Dokono has made a startling revelation about how she ended up in a relationship with actor David Dontoh.
According to her, she went into a relationship with David because some women were chasing after her for homosexual activities.
Appearing on UTV's United Showbiz Saturday, Maame Dokono told host, Nana Ama McBrown that whenever they traveled out for events, both male and female fans came to their hotels wanting to meet her.
She disclosed that, eventually, it appeared that some of them including women wanted to date her. She said upon realizing that, she decided to go into a relationship with David Dontoh who was also in the Obra Drama Group.
Maame Dokono revealed she dated David for over 10 years before they decided to go their separate ways. According to her, she already had 4 children at the time and David was a young man who needed to start her own family so she allowed him to go.
A post shared by Peace 104.3 FM (@peace104.3fm)
Source: Ghanaguardian.com


If your flash drive or flash memory card is out of order, is it worth fixing, that is, if you are missing content and can you restore it in other ways. If the information you are not too interested in just format the memory using the corresponding software (often included is a special CD). The same operation can be done with the help of your computer. If you want to save information from stick, then either contact the professionals and pay about 2 tr, or venture to try and repair it yourself. Up to you. If you decide to deal with the problem yourself, start with a sector copy. This will help utilities Paragon, Acronis and the like.
Sometimes, just go to Control Panel, select Administrative Tools, and from there go to Computer Management and Disk Management. In this case, check running "skandiskom." But this method does not always work. If does not work, resort to programs like R-Studio, GetDatBack, RecoverMyFiles, EasyRecovery, etc. These programs provide the ability to copy information without changing the data structure. However, using these programs, carefully monitor your actions and contact directories or specialized forums, if in doubt. After all, haste can lead to irretrievable loss of data. Very often Leather USB flash drive USB flash drive or a flying stop to recognize the computer. In this case, the message "Insert CD in the drive …." Cope with a special tool to help you.
Each model, the stick fit their own program. To do this, you can turn to the Internet. Which shows the base for more than 700 models of flash drives. There are situations in which flash drive is working, but can only work with USB ports of the motherboard. It sways in the particularly flash drives Transcend JetFlash (flash drive, a rabbit, flash drive, pen). Do not try to connect them to the front extension cords or connectors PC. In this case, it's just useless. If you have problems with copying data from a flash drive, you want to download the driver device manufacturer, choose the appropriate utility and perform low-level format. However, there is a risk that after this procedure, part of the stick still remains unavailable. Some useful tools for flash drives can be found on the Internet. To fit Jetflash Transcend Jetflash 120 Recovery Tool. FLASH DOCTOR RUSSIAN v1.0.2 fairly universal and suitable for different types of flash drives and memory cards. Flash Memory Toolkit 1.1 allows you to make a diagnosis and some remedial measures for various flash drives. Utility HP USB Disk Storage Format Tool to format various flash drives and not take up much space on the disk. If you plan to work with restoration photos and videos, you will F-Recovery. Today the market is extremely saturated with software – you just select the desired program and its version.