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The association between serum folate and gestational diabetes mellitus: a large retrospective cohort study in Chinese population
Xiao-Hui Liu, Zhi-Juan Cao, Li-Wei Chen, Dong-Lan Zhang, Xiao-Xian Qu, Yu-Hong Li, Yu-Ping Tang, Yi-Rong Bao, Hao Ying
Published online by Cambridge University Press: 12 September 2022, pp. 1-8
To investigate the association between folate levels and the risk of gestational diabetes mellitus (GDM) risk during the whole pregnancy.
In this retrospective cohort study of pregnant women, serum folate levels were measured before 24 gestational weeks (GW). GDM was diagnosed between 24th and 28th GW based on the criteria of the International Association of Diabetes and Pregnancy Study Groups. General linear models were performed to examine the association of serum folate with plasma glucose (i.e. linear regressions) and risk of GDM (i.e. log-binomial regressions) after controlling for confounders. Restricted cubic spline regression was conducted to test the dosage–response relationship between serum folate and the risk of GDM.
A sigle, urban hospital in Shanghai, China.
A total of 42 478 women who received antenatal care from April 2013 to March 2017 were included.
Consistent positive associations were observed between serum folate and plasma glucose levels (fasting, 1-h, 2-h). The adjusted relative risks (RR) and 95 % CI of GDM across serum folate quartiles were 1·00 (reference), 1·15 (95 % CI (1·04, 1·26)), 1·40 (95 % CI (1·27, 1·54)) and 1·54 (95 % CI (1·40, 1·69)), respectively (P-for-trend < 0·001). The positive association between serum folate and GDM remained when stratified by vitamin B12 (adequate v. deficient groups) and the GW of serum folate measurement (≤13 GW v. >13 GWs)
The findings of this study may provide important evidence for the public health and clinical guidelines of pregnancy folate supplementation in terms of GDM prevention.
Copy number variation of WBP1L gene revealed its association with growth traits across Chinese cattle populations
Jiaqiang Zhang, Zijing Zhang, Xian Liu, Yanan Chai, Peng Yang, Jungang Li, Yajun Huang, Lijuan Li, Weihong Huang, Guojie Yang, Zengfang Qi, Fuying Chen, Zhiming Li, Chuzhao Lei, Qiaoting Shi, Baorui Ru, Eryao Wang, Yongzhen Huang
Journal: The Journal of Agricultural Science , First View
Copy number variation (CNV) is a very common type of gene variation with high frequency. In recent years, CNV has been paid more attention in various fields, especially in livestock and poultry breeding, which has promoted the progress of breeding. WW domain binding protein 1-like (WBP1L) is a protein coding gene, which plays an important role in cattle populations, and its function has been extensively studied, but it is not clear whether the copy number of the gene can affect the growth and development of cattle populations. In this study, CNV of WBP1L gene was detected in 732 cattle of seven breeds (Qinchuan cattle, QC; Pinan cattle, PN; Yuengling cattle, YL; Xianan cattle, XN; Jiaxian cattle, JX; natural Guyuan cattle, NGY; Jian cattle, JA). In addition, the relationship between CNV and growth phenotype of cattle was studied. The experimental data indicate that the copy number of WBP1L was obviously correlated with heart girth of PN cattle (**P < 0.01), rump length (RL) and body weight (BW) of PN cattle (*P < 0.05), withers height (WH), RL, body length, chest depth and BW of JX cattle (*P < 0.05), WH of NGY cattle (*P < 0.05) and WH of JA cattle (*P < 0.05). It was proved that CNV of WBP1L gene could be used as molecular marker locus for genetic breeding of the above four cattle breeds.
Study on influential factors and reference values for thyroid volume in Chinese children aged 6–12 years
Shuli An, Weidong Li, Xiaofeng Wang, Yanling Wang, Xian Xu, Guangming Mao, Xiaonan Zhu, Ming Li, Lanchun Liu, Xiaotao Cao, Fangang Meng, Peng Liu
Journal: British Journal of Nutrition , First View
Published online by Cambridge University Press: 11 July 2022, pp. 1-9
The purpose of the current study was to research the factors influencing thyroid volume (TVOL) in 6–12-year-old children and update the reference values. A cross-sectional study was carried out in iodine-sufficient areas of four provinces in China. Urine, edible salt and drinking water samples were collected from children. Children's height, weight and TVOL were measured. Ridge regression was used to screen variables for solving the multicollinearity problem. Quantile regression was used to analyse the relationship between the quantiles of TVOL and other variables. In total, 5653 children aged 6–12 years were enrolled in this study, including 2838 boys and 2815 girls. There was no significant difference in TVOL between boys and girls (P > 0·05). Spearman correlation analysis showed that total TVOL was positively correlated with age, height, weight, body surface area (BSA) and BMI, and the correlation coefficients were 0·616, 0·663, 0·669, 0·685 and 0·479, respectively. Among them, the correlation between TVOL and BSA was the strongest. According to the ridge regression results, age and BSA influenced TVOL, and the ridge regression coefficients were 0·13 and 0·94, respectively. Quantile regression further showed that age and BSA had significant influences on the whole TVOL distribution (P < 0·001). Therefore, the TVOL of children aged 6–12 years in China was mainly influenced by age and BSA, and reference values for TVOL of different genders based on age and BSA were established.
Dietary inflammatory index, inflammation biomarkers and preeclampsia risk: a hospital-based case–control study
Yan-hua Liu, Lu Zheng, Chen Cheng, Shu-na Li, Nitin Shivappa, James R. Hebert, Wen-jun Fu, Xian-lan Zhao, Yuan Cao, Wei-feng Dou, Hua-nan Chen, Dan-dan Duan, Quan-jun Lyu, Fang-fang Zeng
Published online by Cambridge University Press: 18 May 2022, pp. 1-9
This study evaluated the association between inflammatory diets as measured by the Dietary Inflammatory index (DII), inflammation biomarkers and the development of preeclampsia among the Chinese population. We followed the reporting guidelines of the Strengthening the Reporting of Observational Studies in Epidemiology statement for observational studies. A total of 466 preeclampsia cases aged over 18 years were recruited between March 2016 and June 2019, and 466 healthy controls were 1:1 ratio matched by age (±3 years), week of gestation (±1 week) and gestational diabetes mellitus. The energy-adjusted DII (E-DII) was computed based on dietary intake assessed using a seventy-nine item semiquantitative FFQ. Inflammatory biomarkers were analysed by ELISA kits. The mean E-DII scores were −0·65 ± 1·58 for cases and −1·19 ± 1·47 for controls (P value < 0·001). E-DII scores positively correlated with interferon-γ (r s = 0·194, P value = 0·001) and IL-4 (r s = 0·135, P value = 0·021). After multivariable adjustment, E-DII scores were positively related to preeclampsia risk (P trend < 0·001). The highest tertile of E-DII was 2·18 times the lowest tertiles (95 % CI = 1·52, 3·13). The odds of preeclampsia increased by 30 % (95 % CI = 18 %, 43 %, P value < 0·001) for each E-DII score increase. The preeclampsia risk was positively associated with IL-2 (OR = 1·07, 95 % CI = 1·03, 1·11), IL-4 (OR = 1·26, 95 % CI = 1·03, 1·54) and transforming growth factor beta (TGF-β) (OR = 1·17, 95 % CI = 1·06, 1·29). Therefore, proinflammatory diets, corresponding to higher IL-2, IL-4 and TGF-β levels, were associated with increased preeclampsia risk.
Effect of breast milk oral care in infants who underwent surgical correction of ventricular septal defect – EXPRESSION OF CONCERN
Xian-Rong Yu, Yu-Qing Lei, Jian-Feng Liu, Zeng-Chun Wang, Hua Cao, Qiang Chen
Journal: Cardiology in the Young / Volume 32 / Issue 3 / March 2022
Published online by Cambridge University Press: 24 March 2022, p. 511
Disaster Preparedness Among Populations in Shenzhen, China, With and Without Chronic Disease
Yu-Ju Qin, Jia-Hong Liu, Yao-Jie Xie, Shao-ling Wang, Xian-liang Liu, Alice Yuen Loke, Bei-Rong Mo
Journal: Disaster Medicine and Public Health Preparedness , First View
Published online by Cambridge University Press: 18 February 2022, pp. 1-8
This survey examined and compared the disaster perception and preparedness of 2421 residents with and without chronic disease in Shenzhen, China.
The participants were recruited and were asked to complete a survey in 2018.
Three types of disasters considered most likely to happen in Shenzhen were: typhoons (73.5% vs 74.9%), major transport accidents (61.5% vs 64.7%), and major fires (60.8% vs 63.0%). Only 5.9% and 5% of them, respectively, considered infectious diseases pandemics to be likely. There were significant differences between those with and without chronic disease in disaster preparedness, only a small percentage could be considered to have prepared for disaster (20.7% vs 14.5%). Logistic regression analyses showed that those aged 65 or older (odds ratio [OR] = 2.76), who had attained a Master's degree or higher (OR = 2.0), and with chronic disease (OR = 1.38) were more prepared for disasters.
Although participants with chronic disease were better prepared than those without, overall, Shenzhen residents were inadequately prepared for disasters and in need of public education.
544 - Validation of a new cognitive screening tool, the Brain Health Test-7, for identification of mild cognitive impairment and early dementia in 3 differentkinds of hospital settings
Meng-Shiuan Shie, Mei Xian Loi, His-Chung Chen, Ming-Hsien Hsieh, Yi-Ting Lin, Chen-Chung Liu, Pei-Ning Wang, Jiahn-Jyh Chen, Cheng-Sheng Chen, Chih-Cheng Hsu, Tzung-Jeng Hwang
Journal: International Psychogeriatrics / Volume 33 / Issue S1 / October 2021
Published online by Cambridge University Press: 01 November 2021, pp. 86-87
The Brain Health Test-7 (BHT-7) is a revised tool from the original BHT, containing more tests about frontal lobe function. It was developed with theaim of identifying patients with mild cognitive impairment (MCI) and early dementia.
Here we report the validity of the BHT-7 versus the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in differentpsychiatry or neurology clinics.
Patients with memory complaints were recruited in this study from the outpatient clinic of psychiatry or neurology in 3 different kinds of hospitals. Allpatients underwent the evaluation of the BHT-7, MMSE, MoCA, and clinical dementia rating (CDR). The clinical diagnosis (normal, MCI, dementia) was made by consensus meeting, taking into account all available data.
Demographic data and the scores of the MMSE, MoCA, and BHT-7 between groups were compared. Logistic regression was adopted for analysis of optimal cutoff values, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), receiver operating characteristic (ROC) curve,and the area under the ROC curve (AUC).
We enrolled a total of 1090 subjects (normal 402, MCI 317, dementia 371); of them, 705 (64.7%) were female. There was a statistically significant differencein age, years of education, and 3 cognitive test scores among the 3 groups.
Compared with the MMSE and MoCA, the BHT-7 performed slightly betterthan MMSE and MoCA in differentiating MCI or dementia from the normalcontrols (Table 1). For BHT- 7, the cutoff point was 17 between normal andMCI, and 14 between normal and dementia. These cutoff points for BHT-7were consistent through 3 different clinical settings, but inconsistent for MMSE and MoCA. The testing time for the BHT-7 was about 5-7 minutes, shorter than that of the MMSE and MoCA.
Compared with MMSE and MoCA, the BHT-7 showed slightly better performance in differentiating normal from MCI or dementia subjects. The testing time for the BHT-7 was shorter, and its cutoff points were consistent through different outpatient clinic settings. The results support that BHT-7 is auseful cognitive screening tool for MCI or early dementia in various hospital settings.
Comparisons of the performance of BHT-7, MMSE, MoCA
Normal vs. MCI
BHT-7 0.8532 ≦17 0.8170 0.7413 0.7135 0.8371
MMSE 0.8061 ≦27 0.7950 0.6883 0.6684 0.8091
MoCA 0.8316 ≦25 0.8202 0.6791 0.6684 0.8273
Normal vs. Dementia
Normal vs. MCI + Dementia
New detrital zircon U–Pb insights on the palaeogeographic origin of the central Sanandaj–Sirjan zone, Iran
Farzaneh Shakerardakani, Franz Neubauer, Xiaoming Liu, Yunpeng Dong, Behzad Monfaredi, Xian-Hua Li
Journal: Geological Magazine / Volume 158 / Issue 12 / December 2021
New detrital U–Pb zircon ages from the Sanandaj–Sirjan metamorphic zone in the Zagros orogenic belt allow discussion of models of the late Neoproterozoic to early Palaeozoic plate tectonic evolution and position of the Iranian microcontinent within a global framework. A total of 194 valid age values from 362 zircon grains were obtained from three garnet-micaschist samples. The most abundant detrital zircon population included Ediacaran ages, with the main age peak at 0.60 Ga. Other significant age peaks are at c. 0.64–0.78 Ga, 0.80–0.91 Ga, 0.94–1.1 Ga, 1.8–2.0 Ga and 2.1–2.5 Ga. The various Palaeozoic zircon age peaks could be explained by sediment supply from sources within the Iranian microcontinent. However, Precambrian ages were found, implying a non-Iranian provenance or recycling of upper Ediacaran–Palaeozoic clastic rocks. Trace-element geochemical fingerprints show that most detrital zircons were sourced from continental magmatic settings. In this study, the late Grenvillian age population at c. 0.94–1.1 Ga is used to unravel the palaeogeographic origin of the Sanandaj–Sirjan metamorphic zone. This Grenvillian detrital age population relates to the 'Gondwana superfan' sediments, as found in many Gondwana-derived terranes within the European Variscides and Turkish terranes, but also to units further east, e.g. in the South China block. Biogeographic evidence proves that the Iranian microcontinent developed on the same North Gondwana margin extending from the South China block via Iran further to the west.
Delayed germination of Brassica parachinensis seeds by coumarin involves decreased GA4 production and a consequent reduction of ROS accumulation
Bing-Xian Chen, Yuan-Xuan Peng, Xue-Qin Yang, Jun Liu
Journal: Seed Science Research / Volume 31 / Issue 3 / September 2021
Published online by Cambridge University Press: 10 August 2021, pp. 224-235
The plant allelochemical coumarin effectively inhibits the germination of Brassica parachinensis (B. parachinensis) seeds. Quantification of endogenous phytohormones showed that contents of abscisic acid (ABA), ABA glucose ester, gibberellin A20 (GA20), GA3, GA15, GA24, GA9 and GA4 were higher in germinating seeds than in seedlings. Moreover, the presence of coumarin significantly reduced the content of bioactive GA4 which is thought to positively regulate seed germination. Histochemical staining and spectrophotometry of reactive oxygen species (ROS) revealed that exogenous GA3 and GA4+7 could effectively promote the production of endogenous ROS during germination and that the GA synthesis inhibitor paclobutrazol could effectively inhibit production of ROS. Coumarin significantly inhibited the accumulation of ROS, especially superoxide anion radical ( ${\rm O}_2^{{\cdot}{-}} $). This inhibitory effect could be restored by the addition of exogenous GA3 and GA4+7. Coumarin also inhibited the activity of the ROS-degrading enzymes such as superoxide dismutase, catalase and peroxidase as well as β-amylase in seeds and seedlings. Taken together, we propose a model for the regulation of seed germination in B. parachinensis by coumarin, Gas and ROS, in which coumarin may delay seed germination by reducing endogenous GA4, thus decreasing the accumulation of ROS.
Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study
Xue-Min Huang, Yan-Hua Liu, Han Zhang, Yuan Cao, Wei-Feng Dou, Dan-Dan Duan, Hua-Nan Chen, Yacong Bo, Adwoa N. Amoah, Wen-Jun Fu, Xian-Lan Zhao, Fang-Fang Zeng, Yu-Ming Chen, Quan-Jun Lyu
Journal: British Journal of Nutrition / Volume 128 / Issue 1 / 14 July 2022
Published online by Cambridge University Press: 06 August 2021, pp. 84-92
Print publication: 14 July 2022
The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case–control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a seventy-eight-item semi-quantitative FFQ. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem MS. Multivariate conditional logistic regression was used to estimate OR and 95 % CI. Restricted cubic splines (RCS) were plotted to evaluate the dose–response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the OR of the highest quartile were 0·45 (95 % CI 0·29, 0·71, Ptrend = 0·001) for VD dietary intake and 0·26 (95 % CI 0·11, 0·60, Ptrend = 0·003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0·02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0·02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.
A cryoprotectant supplemented with pentoxifylline can improve the effect of freezing on the motility of human testicular sperm
Yang Xian, Min Jiang, Bo Liu, Wenrui Zhao, Bin Zhou, Xiao Liu, Shasha Liu, Fuping Li
Journal: Zygote / Volume 30 / Issue 1 / February 2022
Published online by Cambridge University Press: 22 June 2021, pp. 92-97
This study examined the effect of a cryoprotectant with and without pentoxifylline supplementation on the motility and viability of human testicular sperm, both before and after freezing. Testicular samples were obtained from 68 patients with azoospermia who came to the Andrology Service of West China Second University Hospital, Sichuan University, for testicular biopsies from December 2019 to April 2020. All patients were assigned randomly to two groups: experimental, whose testicular sperm were added to the cryoprotectant with pentoxifylline, and the control, whose testicular sperm were added to the cryoprotectant without pentoxifylline. Both groups used the same freezing and thawing methods. Testicular sperm motility in the experimental group was significantly higher than that of the control group, both before and after cryopreservation. The recovery rate of sperm motility in the experimental group was significantly higher than that of the control group. The percentage of samples with motile testicular sperm in the experimental group was significantly higher than that of the control group after thawing. Sperm viability was unchanged between the experimental and control groups, both before and after freezing. Overall, a pentoxifylline-supplemented cryoprotectant can significantly improve the motility of testicular sperm before and after cryopreservation.
Effect of breast milk oral care in infants who underwent surgical correction of ventricular septal defect
Journal: Cardiology in the Young / Volume 31 / Issue 12 / December 2021
Published online by Cambridge University Press: 22 April 2021, pp. 2015-2018
This study explored the clinical effect of employing breast milk oral care for infants who underwent surgical correction of ventricular septal defect.
A prospective randomised controlled study was conducted in a provincial hospital between January, 2020 and July, 2020 in China. Patients were randomly divided into an intervention group (breast milk oral care, n = 28) and a control group (physiological saline oral care, n = 28). The intervention group was given oral nursing using breast milk for infants in the early post-operative period, and the control group was given oral nursing using physiological saline. Related clinical data were recorded and analysed.
There were no significant differences in age, gender, weight, operation time, cardiopulmonary bypass time, or aortic cross-clamping time between the two groups. Compared with the physiological saline oral care group, the mechanical ventilation duration, the length of ICU stay in the breast milk oral care group were significantly shorter. The time of start feeding and total enteral nutrition were significantly earlier in the intervention group than those in the control group. The incidence of post-operative pneumonia in the breast milk oral care group was 3.6%, which was significantly lower than that of the physiological saline oral care group.
The use of breast milk for oral care in infants who underwent surgical correction of VSD can reduce the incidence of post-operative pneumonia and promote the recovery of gastrointestinal function.
A combination of pirfenidone and TGF-β inhibition mitigates cystic echinococcosis-associated hepatic injury
Erqiang Wang, Zhenyu Liao, Lianghai Wang, Yuan Liao, Xiaodan Xu, Ping Liu, Xian Wang, Jun Hou, Huijiao Jiang, Xiangwei Wu, Xueling Chen
Journal: Parasitology / Volume 148 / Issue 7 / June 2021
Cystic echinococcosis (CE) occurs in the intermediate host's liver, assuming a bladder-like structure surrounded by the host-derived collagen capsule mainly derived from activated hepatic stellate cells (HSCs). However, the effect of CE on liver natural killer (NK) cells and the potential of transforming growth factor-β (TGF-β) signalling inhibition on alleviating CE-related liver damage remain to be explored. Here, by using the CE-mouse model, we revealed that the inhibitory receptors on the surface of liver NK cells were up-regulated, whereas the activating receptors were down-regulated over time. TGF-β1 secretion was elevated in liver tissues and mainly derived from macrophages. A combination of TGF-β signalling inhibitors SB525334 and pirfenidone could reduce the expression of TGF-β1 signalling pathway-related proteins and collagen production. Based on the secretion of TGF-β1, only the pirfenidone group showed a depressing effect. Also, the combination of SB525334 and pirfenidone exhibited a higher potential in effectively alleviating the senescence of the hepatocytes and restoring liver function. Together, TGF-β1 may be a potential target for the treatment of CE-associated liver fibrosis.
In Situ Microscopy Study of ZnO Acid Etching Nanostructures
Fangyuan Liu, Xingxu Lu, Zichao Bian, Xiaohui Song, Guoan Zheng, Pu-Xian Gao
Journal: Microscopy and Microanalysis / Volume 26 / Issue S2 / August 2020
Published online by Cambridge University Press: 30 July 2020, pp. 1464-1466
Print publication: August 2020
Effects of different delivering matrices of β-glucan on lipids in mildly hypercholesterolaemic individuals: a meta-analysis of randomised controlled trials
Dengfeng Xu, Hechun Liu, Chao Yang, Hui Xia, Da Pan, Xian Yang, Ligang Yang, Shaokang Wang, Guiju Sun
Journal: British Journal of Nutrition / Volume 125 / Issue 3 / 14 February 2021
Published online by Cambridge University Press: 07 May 2020, pp. 294-307
Print publication: 14 February 2021
β-Glucan has been reported for its health benefits on blood lipids in hypercholesterolaemic individuals for years. However, people have paid little attention to the effects of β-glucan in populations with mild hypercholesterolaemia as well as the various delivering matrices. Our objective was to perform a meta-analysis to analyse the effects of β-glucan with different delivering matrices in mildly hypercholesterolaemic individuals. After conducting a comprehensive search in Web of Science, PubMed, Scopus and Cochrane Library, a total of twenty-one randomised controlled trials involving 1120 participants were identified to measure the pooled effect. The overall results indicated that consuming a dose of ≥3 g/d of β-glucan for at least 3 weeks could significantly reduce total cholesterol (TC) (−0·27 mmol/l, 95 % CI −0·33, −0·21, P < 0·001) and LDL-cholesterol (−0·26 mmol/l, 95% CI −0·32, −0·20, P < 0·001) compared with the control group in mildly hypercholesterolaemic individuals, while no significant difference was observed in TAG (−0·03 mmol/l, 95% CI −0·11, 0·06, P = 0·521) and HDL-cholesterol (0·01 mmol/l, 95% CI −0·03, 0·04, P = 0·777). There was evidence for modest unexplained heterogeneity in the meta-analysis. In conclusion, β-glucan can significantly reduce risk factors like TC and LDL-cholesterol for CVD in mildly hypercholesterolaemic individuals; furthermore, it appears that the effects of food matrices with both 'solid products' and 'liquid products' where β-glucan was incorporated into were ranked as the best way to exert its beneficial properties, while 'liquid' and 'solid' products were ranked as the second and third positions, respectively.
Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients
Wen-tao Lai, Wen-feng Deng, Shu-xian Xu, Jie Zhao, Dan Xu, Yang-hui Liu, Yuan-yuan Guo, Ming-bang Wang, Fu-sheng He, Shu-wei Ye, Qi-fan Yang, Tie-bang Liu, Ying-li Zhang, Sheng Wang, Min-zhi Li, Ying-jia Yang, Xin-hui Xie, Han Rong
Journal: Psychological Medicine / Volume 51 / Issue 1 / January 2021
Published online by Cambridge University Press: 05 November 2019, pp. 90-101
Print publication: January 2021
The microbiota–gut–brain axis, especially the microbial tryptophan (Trp) biosynthesis and metabolism pathway (MiTBamp), may play a critical role in the pathogenesis of major depressive disorder (MDD). However, studies on the MiTBamp in MDD are lacking. The aim of the present study was to analyze the gut microbiota composition and the MiTBamp in MDD patients.
We performed shotgun metagenomic sequencing of stool samples from 26 MDD patients and 29 healthy controls (HCs). In addition to the microbiota community and the MiTBamp analyses, we also built a classification based on the Random Forests (RF) and Boruta algorithm to identify the gut microbiota as biomarkers for MDD.
The Bacteroidetes abundance was strongly reduced whereas that of Actinobacteria was significantly increased in the MDD patients compared with the abundance in the HCs. Most noteworthy, the MDD patients had increased levels of Bifidobacterium, which is commonly used as a probiotic. Four Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologies (KOs) (K01817, K11358, K01626, K01667) abundances in the MiTBamp were significantly lower in the MDD group. Furthermore, we found a negative correlation between the K01626 abundance and the HAMD scores in the MDD group. Finally, RF classification at the genus level can achieve an area under the receiver operating characteristic curve of 0.890.
The present findings enabled a better understanding of the changes in gut microbiota and the related Trp pathway in MDD. Alterations of the gut microbiota may have the potential as biomarkers for distinguishing MDD patients form HCs.
Associations between urinary iodine concentration, lipid profile and other cardiometabolic risk factors in adolescents: a cross-sectional, population-based analysis
Xiaoxia Wang, Tongzhang Xian, Lina Zhang, Xiaofan Jia, Fuli Man, Li Liu, Jie Zhang, Xianbo Zhang, Dongni Yu, Liang Sun, Qi Zhou, Qi Pan, Lixin Guo
Journal: British Journal of Nutrition / Volume 121 / Issue 9 / 14 May 2019
Published online by Cambridge University Press: 11 February 2019, pp. 1039-1048
Print publication: 14 May 2019
Low urinary iodine concentration (UIC) is associated with dyslipidaemia in adults but is not well characterised in adolescents. Because dyslipidaemia is a cardiovascular risk factor, identifying such an association in adolescents would allow for the prescription of appropriate measures to maintain cardiovascular health. The present study addresses this question using data in the 2001–2012 National Health and Nutrition Examination Survey for 1692 adolescents aged 12–19 years. Primary outcomes were UIC, cardiometabolic risk factors and dyslipidaemia. Data for subjects categorised by low and normal UIC and by sex were analysed by univariate and multivariate logistic regression. Treating UIC as the independent variable, physical activity level, apoB and lipid profiles differed significantly between subjects with low and normal UIC. Subjects with low UIC had a significantly greater risk of elevated total cholesterol (TC) (95 % CI 1·37, 2·81), elevated non-HDL (95 % CI 1·33, 2·76) and elevated LDL (95 % CI 1·83, 4·19) compared with those with normal UIC. Treating UIC as a dependent variable, the risk of low UIC was significantly greater in those with higher apoB (95 % CI 1·52, 19·08), elevated TC (≥4·4mmol/l) (95 % CI 1·37, 2·81) and elevated non-HDL (≥3·11mmol/l) (95 % CI 1·33, 2·76) than in those with normal UIC. These results show that male and female adolescents with low UIC tend to be at greater risk of dyslipidaemia and abnormal cardiometabolic biomarkers, though the specific abnormal parameters differed between sexes. These results may help to identify youth who would benefit from interventions to improve their cardiometabolic risk.
Suicidal behaviours among Chinese adolescents exposed to suicide attempt or death
Zhen-Zhen Liu, Ze-Ying Wang, Qi-Gui Bo, Zhen-Biao Qi, Ru-Juan Xu, Cun-Xian Jia, Xianchen Liu
Journal: Epidemiology and Psychiatric Sciences / Volume 29 / 2020
Published online by Cambridge University Press: 11 December 2018, e12
Suicidal behaviours in adolescents are prevalent and multifactorial. This study was conducted to examine the associations between exposure to suicide attempt (ESA) or suicide death (ESD) and suicidal behaviours in a large sample of Chinese adolescents.
Participants included for the analysis were 11 831 adolescent students who participated in the baseline survey of the Shandong Adolescent Behavior and Health Cohort (SABHC). Participants were sampled from five middle and three high schools in three counties of Shandong province, China. A self-administered structured questionnaire was used to collect data on demographics, behavioural and emotional problems, family environment, suicidal behaviours (suicidal thought, plan and attempt), and history of ESA or death of a family member, relative, friend or close acquaintance. Based on the sources of exposure, the participants were divided into four groups: non-exposure, exposure from relatives only, exposure from friends/close acquaintances only (EFO) and exposure from both relatives and friends (ERF). Logistic regressions were used to examine the associations between ESA or ESD and suicidal behaviours.
Mean age of the participants was 14.97 ± 1.46 years and 50.9% were boys. Of the participants, 9.4% reported having ESA, and 6.6% reported having ESD. The prevalence rates of suicidal behaviours were significantly higher in adolescents who had been exposed to suicide attempt or death than those who had not. Multivariate logistic regressions showed that ESA and ESD were both significantly associated with increased risks of suicidal thought (ESA: OR = 1.96, 95% CI = 1.66–2.31; ESD: OR = 1.59, 95% CI = 1.31–1.94), plan (ESA: OR = 2.37, 95% CI = 1.84–3.05; ESD: OR = 1.62, 95% CI = 1.18–2.23) and attempt (ESA: OR = 2.73, 95% CI = 1.92–3.89; ESD: OR = 1.82, 95% CI = 1.18–2.82), respectively. When participants were exposed to suicide attempt, ERF and EFO groups had significantly higher risks of suicidal thought (ERF: OR = 2.61, 95% CI = 1.28–1.64; EFO: OR = 1.96, 95% CI = 1.64–2.36), plan (ERF: OR = 3.72, 95% CI = 2.04–6.78; EFO: OR = 2.31, 95% CI = 1.74–3.01) and attempt (ERF: OR = 4.83, 95% CI = 2.30–10.17; EFO: OR = 2.57, 95% CI = 1.73–3.81), respectively.
ESA or ESD was associated with increased risks of suicidal behaviours in adolescents. Exposure to suicidal behaviours of relatives and friends/close acquaintances appeared to have different influence on adolescent suicidal behaviours. Further research is warranted to examine the biological and psychosocial mechanisms between suicidal exposure and subsequent suicidal behaviours in adolescents.
The effect of carbon support on the oxygen reduction activity and durability of single-atom iron catalysts
Jin-Cheng Li, Dai-Ming Tang, Peng-Xiang Hou, Guo-Xian Li, Min Cheng, Chang Liu, Hui-Ming Cheng
Journal: MRS Communications / Volume 8 / Issue 3 / September 2018
Print publication: September 2018
Owing to lack of a definitive correlation between carbon supports and catalytic activity of single-atom Fe-active sites, rational design and preparation of single-atom Fe catalysts have so far been elusive. Herein we designed and prepared one-dimensional core–shell nanostructured single-atom Fe catalysts, in which carbon nanofibers and carbon nanotubes with different crystallinities and electrical conductivities were used as supports to host single-atom Fe-active sites. It was found that the carbon supports with higher electrical conductivity accelerate charge transfer and enhance the oxygen reduction reaction (ORR) activity of single-atom Fe-active sites as well as the ORR durability of the final catalyst.
Enhancing grain refinement efficiency and fading resistance of Al–B master alloys processed by equal channel angular pressing
Kun Xia Wei, Yan Wei Zhang, Wei Wei, Xian Liu, Qing Bo Du, Igor V. Alexandrov, Jing Hu
Journal: Journal of Materials Research / Volume 33 / Issue 12 / 28 June 2018
An Al–3% B master alloy has been subjected to equal channel angular pressing (ECAP). The grain refining performance and fading resistance of an Al–3% B master alloy on a commercial purity Al (CPA) have been evaluated. The effect of the number of ECAP passes on the size and the distribution of the AlB2 particles, the grain size of CPA ingots with and without adding the Al–3% B master alloy subjected to ECAP have been investigated. The mean size of AlB2 particles was significantly reduced from ∼34 to ∼12 μm after four ECAP passes. Fine blocky AlB2 particles were uniformly distributed in the Al matrix. It has been revealed that when it was inoculated by the Al–B master alloy subjected to ECAP, the grain size of α-Al was decreased from ∼1200 to ∼180 μm after four ECAP passes, beyond that, the grain size tends to be saturated. It has been proved that grain refinement efficiency and fading resistance of the Al–3% B master alloy subjected to ECAP in CPA ingots was enhanced.

redpajama_set_name: RedPajamaCommonCrawl


We also accept company, bank or cashier's checks. If paying by check, we must receive it before we can process your order.
Wire payments are accepted for orders of $5,000 or more.
You can also use PayPal for orders of $5,000 or more. Please contact our accounting department at 415.693.0189 for instructions.


Do they really hair test?
If you were to leave AVI Foodsystems, Inc, what would be the reason?
Learn more about working at Matheson Trucking Inc.
US Foods® helps our customers make it with products and services that shape the communities where we live and work.


Let me see if I have this right: The world is going in the crapper right now.
So today, another disaster that's causing alarm around the world, a Malaysian airliner is purportedly shot down via a surface to Air missile over eastern Ukraine. 295 people dead. Currently no one knows who's responsible although the money is on the Russians. Too early though to place blame.
In the meantime, we have a serious humanitarian crisis right here in the U.S. Thousands of people, many children crossing the border and no one seems to know how to stop it from happening or what to do with them when they arrive.
Oh, did I forget to mention Israel and Hamas were back at it? Let's not forget the ongoing civil war in Syria where nearly 200,000 are dead in 3 years of conflict.
Then there's the issue of ISIS in Iraq. Not a big deal I guess that a terrorist organization has occupied a third of that country. Where's my beer?
Oh, there's a lot more, like Libya being back in the news, there's still Boko Haram in Nigeria blowing up people almost daily. No. Nothing to be concerned about with any of these situations because our President is on the job.
What was the president doing today about all of these crises you ask? Well, let's see: He gave a speech about "infrastructure" in the U.S and went off topic for 60 seconds basically saying the Malaysian air shoot down was "a tragedy". He then motorcades out to get a burger and a shake; Then jumped on Air Force One to fly to New York for 2 fundraisers.


text:
<?php

/* GrcUserBundle:Manager:ListCollaborateur.html.twig */
class __TwigTemplate_b278aa7bb4677dbc4b68f6fdfd38391bb63f55a623c75fc8c7a1d9935d4e4b21 extends Twig_Template
{
    public function __construct(Twig_Environment $env)
    {
        parent::__construct($env);

        $this->parent = $this->env->loadTemplate("GrcUserBundle::template_manager.html.twig");

        $this->blocks = array(
            'body' => array($this, 'block_body'),
            'admin' => array($this, 'block_admin'),
        );
    }

    protected function doGetParent(array $context)
    {
        return "GrcUserBundle::template_manager.html.twig";
    }

    protected function doDisplay(array $context, array $blocks = array())
    {
        $this->parent->display($context, array_merge($this->blocks, $blocks));
    }

    // line 2
    public function block_body($context, array $blocks = array())
    {
        // line 3
        echo "     ";
        $this->displayParentBlock("body", $context, $blocks);
        echo "
 ";
    }

    // line 5
    public function block_admin($context, array $blocks = array())
    {
        // line 6
        echo "

";
        // line 10
        echo "

                env->getExtension('routing')->getPath("grc_manager_collaborateur_ajout");
        echo "\"><button type=\"button\" value=\"Ajouter\" class=\"btn btn-primary\"> Ajouter  </button>

                    <input type=\"text\" class=\"form-control\" placeholder=\"Search for...\">

                      <button class=\"btn btn-default\" type=\"button\">Go!</button>

";
        // line 29
        echo "

List des collaborateurs

                    ";
        // line 52
        echo "

                          <input type=\"checkbox\" id=\"check-all\" class=\"flat\">
                          ID
                          Username
                          email
                          Roles

                        ";
        // line 63
        $context['_parent'] = (array) $context;
        $context['_seq'] = twig_ensure_traversable((isset($context["comptes"]) ? $context["comptes"] : $this->getContext($context, "comptes")));
        foreach ($context['_seq'] as $context["_key"] => $context["com"]) {
            // line 64
            echo "

                          <input type=\"checkbox\" class=\"flat\" name=\"table_records\">
                          ";
            // line 66
            echo twig_escape_filter($this->env, $this->getAttribute($context["com"], "id", array()), "html", null, true);
            echo "
                          ";
            // line 67
            echo twig_escape_filter($this->env, $this->getAttribute($context["com"], "username", array()), "html", null, true);
            echo "
                          ";
            // line 68
            echo twig_escape_filter($this->env, $this->getAttribute($context["com"], "email", array()), "html", null, true);
            echo "
                          ";
            // line 69
            echo twig_escape_filter($this->env, $this->getAttribute($this->getAttribute($context["com"], "roles", array()), 0, array(), "array"), "html", null, true);
            echo "

                              <button class=\"btn bg-light-blue \" data-toggle=\"modal\" data-target=\"#addUserForm\"></button>
                              env, $this->env->getExtension('routing')->getPath("grc_admin_manager_update", array("id" => $this->getAttribute($context["com"], "id", array()))), "html", null, true);
            echo "\"><button class=\"btn bg-green \"> </button>
                              env, $this->env->getExtension('routing')->getPath("grc_manager_collaborateur_delete", array("id" => $this->getAttribute($context["com"], "id", array()))), "html", null, true);
            echo "\" onclick=\"return confirm('Are you sure?')\" ><button class=\"btn bg-red \" > </button>

                        ";
        }
        $_parent = $context['_parent'];
        unset($context['_seq'], $context['_iterated'], $context['_key'], $context['com'], $context['_parent'], $context['loop']);
        $context = array_intersect_key($context, $_parent) + $_parent;
        // line 77
        echo "

                       ";
        // line 86
        echo "

        <button type=\"button\" class=\"close\" data-dismiss=\"modal\" aria-label=\"Close\">×</button>

Manager

";
        // line 96
        echo "

                    <form class=\"form-horizontal form-label-left\" novalidate>

                        Name *

                          <input id=\"form_roles\" name=\"form[roles]\" class=\"form-control col-md-7 col-xs-12\" data-validate-length-range=\"6\" data-validate-words=\"2\"  required=\"required\" type=\"text\">

                        Email *

                          <input type=\"email\" id=\"email\" name=\"email\" required=\"required\" class=\"form-control col-md-7 col-xs-12\">

                        Confirm Email *

                          <input type=\"email\" id=\"email2\" name=\"confirm_email\" data-validate-linked=\"email\" required=\"required\" class=\"form-control col-md-7 col-xs-12\">

                        Password

                          <input id=\"password\" type=\"password\" name=\"password\" data-validate-length=\"6,8\" class=\"form-control col-md-7 col-xs-12\" required=\"required\">

                        Repeat Password

                          <input id=\"password2\" type=\"password\" name=\"password2\" data-validate-linked=\"password\" class=\"form-control col-md-7 col-xs-12\" required=\"required\">

                        Telephone *

                          <input type=\"tel\" id=\"telephone\" name=\"phone\" required=\"required\" data-validate-length-range=\"8,20\" class=\"form-control col-md-7 col-xs-12\">

                          <button type=\"submit\" class=\"btn btn-primary\">Cancel</button>
                          <button id=\"send\" type=\"submit\" class=\"btn btn-success\">Submit</button>

                    </form>

";
        // line 170
        echo "

      ";
        // line 176
        echo "

     ";
    }

    public function getTemplateName()
    {
        return "GrcUserBundle:Manager:ListCollaborateur.html.twig";
    }

    public function isTraitable()
    {
        return false;
    }

    public function getDebugInfo()
    {
        return array (  242 => 176,  238 => 170,  163 => 96,  152 => 86,  145 => 77,  135 => 73,  131 => 72,  125 => 69,  121 => 68,  117 => 67,  113 => 66,  109 => 64,  105 => 63,  92 => 52,  70 => 29,  52 => 13,  47 => 10,  42 => 6,  39 => 5,  32 => 3,  29 => 2,);
    }
}

redpajama_set_name: RedPajamaGithub


The actress said she was grateful to "I, Tonya" screenwriter Steven Rogers.
Janney also recognized her "I, Tonya" family ("a cast and crew and bird that elevated my work"), as well as Neon and 30 West.
Backstage, Janney, the longtime television actress, told reporters that she hadn't allowed herself to dream about one day winning an Oscar.
The Oscar win continues her awards show sweep this year, with honors that include a Golden Globe, a BAFTA, a SAG Award, and an Independent Spirit Award.


Time for a doughnut party!
(SPOT.ph) Doughnut lovers, rejoice! J.Co Donuts is celebrating their seventh anniversary with the return of their birthday promo. Mark your calendars on March 14 and 15, from 10 a.m. to 6 p.m., because you can get two dozen doughnuts for P500.
The deal includes a box of 12 doughnuts of your choice and another dozen of a set mix, which includes Blueberry More, White Desert, Jacky Chunk, Mr. Green T, Copa Banana, Avocado di Caprio, Choco Caviar Chocolate, Katy Berry, Coco Loco, Meisisipi, Oreology, and Alcapone. Two dozen doughnuts usually go for P625, so this is a deal you wouldn't want to miss!
See a list of J.Co Donuts branches.


text:
Euronext secures clearance from Norway's Ministry of Finance to acquire Oslo Bors VPS
May 13, 2019 8:45 am UTC, Maria Nikolova
Euronext confirms its intention to complete the transaction by the end of June 2019.
Euronext NV (EPA:ENX) has just announced that it has secured clearance from Norway's Ministry of Finance to acquire up to 100% of Oslo Børs VPS's capital. Euronext confirms its intention to complete the transaction by the end of June 2019.
Euronext has already secured a majority of the capital of Oslo Børs VPS (53.4%) including irrevocable pre-commitments, shares tendered to the Offer, and directly owned shares. This satisfies the 50% minimum ownership condition of its offer.
The Ministry's decision was one of the last major conditions to complete the transaction.
Euronext's shareholders have been asked to approve the transaction at the general meeting to be held on May 16, 2019. Euronext's reference shareholders, who represent 23.86% of the capital, have confirmed their joint support for the transaction.
On April 8, 2019, Euronext received the Norwegian Financial Supervisory Authority's (Finanstilsynet) advice to the Norwegian Ministry of Finance, recommending that Euronext should be approved as a suitable owner of up to 100% of the capital of Oslo Børs VPS, as applied for, without ownership or other restrictions.
Euronext reiterated its commitment to the further development of Oslo Børs VPS, both its stock exchange and the Central Securities Depository (CSD), through a client-centric plan benefitting all parties of the Norwegian financial community. Euronext will act accordingly to preserve and develop the specific contribution of Oslo Børs VPS to the Norwegian economy including the Equity Capital Certificates market, the Fish Pool market located in Bergen, the high yield bond market and a seamless efficient listing platform.
Stéphane Boujnah, CEO and Chairman of the Managing Board of Euronext said: "Euronext welcomes the Ministry's clearance to acquire up to 100% of Oslo Børs VPS's capital and look forward to completing the next steps to close the transaction by the end of June 2019. As part of the Euronext family, Oslo Børs VPS will continue to be a strong and leading Nordic exchange and CSD, and a hub for Euronext's ambitions in the region. Euronext looks forward to supporting the Norwegian financial and business community, to working constructively with all key constituents and stakeholders to further drive the success of Oslo Børs VPS."


ADMINISTRIVIA: Down with a bad earache — Argh!
This entry was posted on Thursday, July 14th, 2016 at 10:42 and is filed under ADMINISTRIVIA.	You can follow any responses to this entry through the RSS 2.0 feed. You can skip to the end and leave a response. Pinging is currently not allowed.


Here's a statistic that needs to change: Forty percent of Albuquerque's water is used to water lawns and gardens.
Conservation and preservation are top priorities for the Albuquerque Bernalillo County Water Utility Authority. Like many other communities across the U.S., the ABCWUA uses a water by the numbers schedule to meet their commitment.
Spray irrigation is NOT allowed between 11 a.m. and 7 p.m. from April 1-Oct. 31 and is considered water waste.
Whether you spot water waste on your block, in your neighborhood, or elsewhere in the city and county, ABCWUA wants to know about it. Make sure you know what the definition of water waste is before alerting authorities. Learn about water waste.
Here's where and how you can make your observations known: Report Water Waste.


The left hand image shows a cut through an episcopic dataset prepared from a mouse embryo at E10.5.
The right hand panel is a histological section from a human embryo at Carnegie stage 13 or 14, when the embryo is just over 4 weeks old.
Both sections show the initial growth of the primary atrial septum (septum primum) from the atrial roof.
This page was last modified on 16 February 2017, at 18:12.


text:
The Labchart SDK
----------------
This file is meant to briefly discuss how this repo came about and how the code is organized.

This code is based on the Labchart SDK provided by ADInstruments. An installer for
the SDK can be found in the Labchart folder following installation of Labchart.
The SDK provides a Windows dll and information on what functions are available
in the dll.

A mex file has been written that calls these dll functions from Matlab.
A separate set of Matlab functions exist that expose this mex file to Matlab.
These functions are currently located in adi.sdk (although I plan on moving this).

On top of these functions I've written classes that make it slightly easier
to work with the SDK.

-------------------
Code in the Library
-------------------

The adi package contains all relevant code.

Within the adi package are meant to be relevant entry points.
Ideally I want to move most of the non-entry functions outside of the base package but this is a very low priority

Entry functions include: (may be outdated)
- adi.readFile
- adi.createFile
- adi.editFile
- adi.convert


Nissan has revealed a new technology.
Approximately 28 Americans are fatally injured each day in accidents involving an intoxicated driver.
Autonomous vehicles have the potential to improve transportation of both goods and passengers.


text:
Q: PayPal Mobile Payments, Logins, MPL and MEP files for iOS and PhoneGap I'm trying to set up a mobile PayPal payment for gift cards in an iPhone app using the PhoneGap PayPal plugin but I'm hitting a brick wall:

*

*I can launch a payment and get to the PayPal screen on the simulator but no combination of logins will work for me. I have verified these logins minutes earlier on the PayPal sandbox test site. I am using the sandbox App-ID and ENV_SANDBOX. I am also logged into my sandbox account on my Mac while doing this.

*The log in XCode shows the payment message with all the correct price, items details, etc.

*I have whitelisted th PayPal sites and I don't get whitelist messages in the log.

*On my iPhone 4 with iOS 5.0 I cannot get to the PayPal screen. The log shows the "FILE SYSTEM CHECK ERROR" message. I have read elsewhere that this is to do with jailbroken phones but my phone is definitely not jailbroken.
I have tried just about every combination of ideas I can find but to no avail. So I have to ask:

*

*Does the sandbox work OK for PayPal mobile payments? Has anyone got a successful login sequence?

*The PhoneGap plugin uses a PayPal library file ending in "MEP" but the latest PayPal library uses an "MPL" suffix (or MEC for express checkout). Some of the function calls appear different between MEP and MPL as well. Is this a difference in versions and the PhoneGap plugin is just running an old version library? If so, is this likely to be a cause of issues?

A: I've only tried the MECL library at the moment, because our customer already had a working server backend.
Dunno if this can be of any use to you, but you may have a shot at https://github.com/azicchetti/MECLPayPalPlugin
Unfortunately it doesn't use the MPL library and you need some backend code to complete the express checkout flow. It works, though.
Cheers.

A: Have you created your fake accounts inside your sandbox?
The login when trying to test paying on the sandbox is NOT your paypal.com login, and is NOT your developer.paypal.com login.
Additionally, you must FIRST log into developer.paypal.com before your fake sandbox accounts will be recognized by the sandbox... This might be hard to do on a mobile device.

redpajama_set_name: RedPajamaStackExchange


text:
Should Your Family Business Have a "No In-Laws" Policy?
The short answer: maybe.
Christina R. Wing
Rohit K. Gera
HBR Staff/Getty Images
Should in-laws, even if they're highly qualified, work in the family business? While there's no "one-size-fits-all" guideline, if you are considering involving in-laws in the family business, it's important to think through some general policies in advance. Document a family work policy. The policy should define "family" and specific rules for how the different types of family can work in the business. There should be rules on reporting structures, succession plans, and who is allowed to revise such policies. Develop solid HR practices for reviews, bonuses, and terminations for all employees, as well as transparency around promotions and authority. Before you invite in-laws into the business, know how you will get them out. Most employees are at-will, but family isn't at-will, so spell out your concerns in advance, document performance results, and have a predetermined trial period to review. This also creates an environment that feels safe and fair.
Separating work from home and business from love is complicated in a family business. In any business, management should have a strong say in who works for the company, but management shouldn't have a say when it comes to who marries whom. It is extremely important to acknowledge that bringing in-laws into a family business and getting it wrong can damage both the family and the business. And bringing the boardroom into the bedroom can quickly become a toxic situation in any marriage.
Should in-laws, even if highly qualified, work in the family business?
In our research, families tend to have polarizing views on this. They either forbid in-laws from joining the family business altogether, keeping ownership rights and jobs for blood relatives, or they have an inclusive policy that welcomes in-laws. There are pros and cons for both scenarios.
Based on our own experience with family businesses, a policy against bringing in-laws into the business may be best, as it sets clear rules and expectations. There are frequently power struggles in family businesses, and this policy enables couples to have some aspect of their life that isn't intertwined with the rest of the family. It also encourages the family to welcome and evaluate the in-law as a spouse, not as an employee. Having a policy in advance makes it less personal, whereas if you create one after an in-law whom you don't like joins the family, it will breed resentment. Such a policy can also prevent friction between family members who were born into the business, as opposed to those who married into it. Having a clear separation between married life and work life minimizes pressure for everyone.
Leading a Family Business
Sponsored by Northern Trust
Best practices for long-term success.
A policy against in-laws working in the family business also mitigates the risks if a divorce happens. It's an important consideration, as divorce in a family business can have serious consequences that can affect ownership rights, employment rights, and reputations, and can be a huge distraction for the business. Families can't safeguard against all of these risks, but it is prudent to have a prenuptial agreement that protects the ownership of the business, and in-laws should have employment contracts, just like non-family employees who have a non-compete clause in their contracts.
However, there are several wrinkles to the "no in-laws" policy. Inflexible, legally delineated rules can also drive blood relatives away. Most family businesses want to "keep it in the family", and children often get "the call" to come home and join the business. Their spouses might be required to make career sacrifices of their own to support a spouse in the family business. And since family-owned business make up 80-90% of businesses worldwide, it could be difficult for in-laws to find meaningful employment if it's not with their new family. Furthermore, the business may be missing out on competent trusted talent, as marriage can introduce highly qualified individuals to the business.
Many families with a "no in-laws" policy feel the need to support in-laws by giving them seed money for businesses of their own (often considered "go-away money"). But such a strategy often goes awry unless investments are based on merit, and results are clearly communicated.
One family business that we advised had a strict "no in-laws" policy, specifically created to prevent a disliked son-in-law from joining the business. When the managing father died unexpectedly without a family successor, the business fell apart, as the siblings weren't united around a forward-looking plan. This dissolution might have been avoidable had the "rule" been to let in-laws into the business based on merit, as there was another son-in-law who was highly qualified to run the business.
We also interviewed a large beverage company in its tenth generation that has a "no in-laws" policy. Everyone understands the policy as gospel, and welcomes it. In fact, it has led to greater gender diversity within the company as daughters are taking the reins from fathers and more women are being groomed from childhood to be active in their family businesses, which span a variety of industries and geographic areas. Despite the large size of the family, this policy, along with other policies in the family constitution, have provided some necessary guardrails that have allowed the business and family to prosper.
Of course, there are plenty of examples of in-laws working in the family business that have proven successful. In one, a couple was faced with the unexpected illness of the wife's father, who had been running the business. The couple moved across the globe for the wife to run the family business. Her husband (the son-in-law) jumped in as well, putting aside major outside career opportunities to assist the family business. The business has thrived, but sacrifices were made.
In another business, an in-law played an integral role in destroying a family business. The business had a father and son working together who came to blows. A son-in-law, Tom (identity protected), used this as an opportunity to get in with the father and push the son out. It worked temporarily, until the father and son buried the hatchet. They recognized Tom's deceit and fired him. This led to an estrangement between the daughter, Sara (identity protected) and the family. Sara and Tom eventually divorced, but that wasn't the full extent of the damage. Due to the lack of professionalism and the leadership vacuum, employees and clients started to leave the business. Sara had split her ownership of the company jointly with Tom. Subsequently, they were very slow to make decisions, as Sara had little knowledge of the business, while Tom tried to sabotage the company out of anger and vengeance. The entire family eventually lost the business.
There's no "one-size-fits-all" guideline when it comes to having in-laws in the family business. But it's important to clearly separate in-law ownership and in-law employment in the family business, as these roles have very different responsibilities and authority.
Every family business is unique, with their own family dynamics. It's essential to think through the myriad issues before establishing a policy. To name a few, how will reporting, compensation, and evaluations work? Objective evaluation of a sibling's spouse, for example, can be tricky. As the business and family grow, these issues only get magnified.
If you are considering involving in-laws in the family business, consider these general suggestions:
Put family first. A family in disarray cannot run a successful business.
Clarify business goals, family goals, and individual goals.
Document a family work policy. The policy should define "family" and specific rules for how the different types of family can work in the business. There should be rules on reporting structures, succession plans, and who is allowed to revise such policies.
Create a compensation and equity committee made up of a combination of family and professional managers who report to the board. If you are too small to have a board, hire an independent advisor to help with compensation.
Develop solid HR practices for reviews, bonuses, and terminations for all employees, as well as transparency around promotions and authority.
Be kind to each other and support and engage the in-laws in the business.
Minimize pillow talk, as spouses often have distorted views of each other and negativity is a slippery slope.
Be generous with your time and mentoring; marriage is hard enough without an in-law joining a family feeling like a second-class citizen.
Develop an off ramp. Before you invite in-laws into the business, know how you will get them out. Most employees are at-will, but family isn't at-will, so spell out your concerns in advance, document performance results, and have a predetermined trial period to review. This also creates an environment that feels safe and fair.
Create a culture that is safe, develops talent, has strong feedback loops, and has a common goal. If an in-law will detract from that culture, keep them out of the family business.
Regardless of what you decide in terms of in-laws working in the family business, they should be included as family members of the business, and should be updated on the business status and governance policies annually, and encouraged to ask questions. Demystifying the business will make things smoother at home. Be sure to also carve out family time where the business isn't discussed, to create a strong family culture. In-laws can be a great source of strength and support. Often they are the biggest unsung heroes in a family and a family business, and if they're included properly, they can be great ambassadors for the brand.
Family businesses that succeed in the long-term have a shared set of values, deep personal relationships, family pride, and trust amongst individual family members. It can be extremely difficult to penetrate this unity by bringing a new in-law — an outsider to the larger family — into the business. While there can be very positive outcomes, the process is fraught with risk and requires thoughtful analysis and policies.
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Christina R. Wing is on the Faculty at Harvard Business School as a Senior Lecturer teaching Leadership and Corporate Accountability and Demystifying Families in Business. She co-chairs the Executive Education Program at HBS on Families in Business and is an active speaker and advisor to families in business globally.
Rohit K. Gera is the Managing Director of a third generation real estate development business in India and the United States. Based in Pune, India, Rohit has been leading his family business for the past 8 years and is active with many other family-owned businesses in India.


text:
Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat
Pyne, N J and Anderson, N and Lavan, B E and Milligan, G and Nimmo, H G and Houslay, M D (1987) Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat. Biochemical journal, 248 (3). pp. 897-901. ISSN 0264-6021
Polyclonal-antibody preparations DV1 and PM1, raised against purified preparations of rat liver insulin-stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases, were used to analyse rat liver homogenates by Western-blotting techniques. The antibody DV1 identified only the 63 kDa native subunit of the 'dense-vesicle' enzyme, and the antibody PM1 only the 52 kDa subunit of the plasma-membrane enzyme. These antibodies also detected the subunits of these two enzymes in homogenates of kidney, heart and white adipose tissue from rat. Quantitative immunoblotting demonstrated that the amount of these enzymes (by wt.) varied in these different tissues, as did the expression of these two enzymes, relative to each other, by a factor of as much as 7-fold. The ratio of the dense-vesicle enzyme to the peripheral-plasma-membrane enzyme was lowest in liver and kidney and highest in heart and white adipose tissue. ICI 118233 was shown to inhibit selectively the 'dense-vesicle' cyclic AMP phosphodiesterase in liver. It did this in a competitive fashion, with a Ki value of 3.5 microM. Inhibition of tissue-homogenate cyclic AMP phosphodiesterase activity by ICI 118233 was used as an index of the contribution to activity by the 'dense-vesicle' enzyme. By this method, a tissue distribution of the 'dense-vesicle' enzyme was obtained which was similar to that found by using the immunoblotting technique. The differential expression of isoenzymes of cyclic AMP phosphodiesterase activity in various tissues might reflect a functional adaptation, and may provide the basis for the different physiological actions of compounds which act as selective inhibitors.
Pyne, N J ORCID: https://orcid.org/0000-0002-5657-4578, Anderson, N, Lavan, B E, Milligan, G, Nimmo, H G and Houslay, M D
3',5'-cyclic-AMP phosphodiesterases, animals, antibodies, antibody specificity, cell membrane, kinetics, male, pyridazines, rats, rats, inbred strains, tissue distribution, Pharmacy and materia medica, Biochemistry, Cell Biology, Molecular Biology
Medicine > Pharmacy and materia medica
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences


Time Out comes out this week with a big cover-story poll on the New York critics. In every field.
We set out to review the reviewers, our own included. First, we developed a system of grading, on a scale of one to six, using five categories: knowledge, style, taste, accessibility and influence. Next, we enlisted panelists, from publicists to curators and artists—in other words, the people most likely to be directly affected by criticism—to use our system to rate NYC's arbiters of taste and to provide (anonymous) comments.
Complete list of panelists here. Even some bloggers' votes were also solicited, including yours truly.
So take a look at the theatre roundup. You may be surprised.
For instance, lowest scoring? Hilton Als! Not Charles Isherwood.
So, according to this panel (on which either no playwrights were asked to participate, or agreed to) the most "stylish" theater writer in New York is John Simon?
Terry Teachout has some coverage of it as well.
Yes, I recommend Isaac's post at Parabasis, and follow his link to Appollonaire at artsjournal.com.
The inclusion of the "Influence" category does indeed skewer the theatre poll to the Times critics. So that methodology is worth questioning.
However--note that the Times critics do NOT rank highest in the other categories, like film and music. Who knew that the Voice, for instance, was more "influential" in film than in theatre!
A slight sidetrack, but the Voice's putative "influence" in film seems to be skewed by an overreliance in the (tiny) sample on "downtown" movie types, indie movie publicists and the like. Also, in movies, as opposed to the other fields, it's extremely peculiar to leave out critics who write for national publications but to include The New Yorker as if it's a local city mag.
Here's a re-ranking if you remove influence, which, as you and Isaac point out, doesn't belong here, and also remove "accessibility" (which I would argue should really be a part of "style"). So this is the Time Out ranking by what I would call the critical essentials: Knowledge, taste and style.
That said, I still think you'd need to get about ten times the number of theater professionals, bloggers, etc. to participate for this to be useful. Hilton Als is, in no remotely realistic version of the theater universe, the worst critic in New York, or close to it. And while I'm sure there are people out there who would still argue that John Simon is the best, I bet his top ranking would not hold in any sampling larger than 20 people.
And how about some commentary on the preponderance of white men in the job. One woman and one man of color in 2006. Not at all to say that all white men bring the same set of tastes, which is as silly as it is false. But who would argue that some diversity of background and life-experience wouldn't make for an overall richer discourse? And why -- genuine question, not rhetorical -- do people think this hasn't changed at all?
Final question (sorry about the long post): Why wasn't Brustein at New Republic included? And, speaking of the paucity of women, doesn't Alexis Soloski count?
In another pointless but fascinating focus on critics, last week, Britain's Independent ranked "Fleet Street's theatre critics" (I resort to scare quotes because they didn't stick to Fleet Street but they did leave out some important critics). Also mostly male and predominantly Oxbridge.
It's also worth noting on the taste/sensibility front that, in a situation such as Brantley vs. Isherwood, you can never get a true comparison because--writing for the same publication--they do not review the same shows.
unfortunately for david cote (whose reviews i've both appreciated and been baffled by), coming out on top of a list where isherwood is #2 is a bit like being named greatest movie on a list where "crash"* is ranked second. kinda takes away any credibility of the thing.


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text:
Individuals contribute – but it's teams that win
It's best teams that win, not the most talented individuals
We've all been there, first day in a new job. You know, that moment of discomfort. You can feel them eyeing you as you walk in the room trying to look nonchalant. You have already in a flash made up your mind about a few of the people there. You don't like the one who sniffs all the time and Mr. Egghead clearly doesn't like you and here comes Miss Bossy to make you feel at home. Yet being part of a team is the reality of the modern workplace and being a successful part of it is vital to your career. While a lot has been written about talent, rather less has been written on the creation of top teams. A lot of consultants have, for instance, focused on individual talent. But increasingly that magic cocktail of a great talented team is being seen as the key to corporate success. If you can be a great team player and understand how to make teams outperform their potential you will be a winner and your career will flourish.
Team dynamics and team harmony – how you get them
Most of us would rather go out with some friends and have dinner than work as, let's say, a team member improving the "Neighborhood Watch" scheme or having an oversized meeting to discuss how to raise money for the church roof. I'm not convinced most of us are park animals. In our own minds we are still hunter-gatherers-wannabe Matt Damons, ready to take arms against a world of adversaries. But in a world that has become:
Increasingly full of risk
Increasingly female
We shall have to put on a team uniform if we want to get ahead. There is no choise.
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Georgia Tech, positioned on a 400-acre campus in Atlanta, is component of the University Method of Georgia. It was founded throughout the reconstruction era to help rebuild the industrial infrastructure of the South. It has grown into a renowned study institution with far more than 23,000 students and satellite campuses across the globe. The very first degree presented was in mechanical engineering, and the institute remains robust in the applied sciences. The school awards more engineering degrees to females than any other.
Lehigh offers 10 net-based master's programs , and all but two are in engineering. Engineering master's online incorporate biological and chemical engineering, chemical energy engineering, chemical engineering, healthcare systems engineering, management science and engineering, and manufacturing systems engineering. Each system is 30 or 31 credits some demand a thesis or a capstone project. A GPA of 2.75 or greater is needed for admittance. Function expertise is essential for some applications. Courses are delivered in two approaches: Classroom Reside, which attributes interactive, genuine-time recording from actual classrooms and Classroom On the internet, which is asynchronous and can be accessed at any time. Some courses consist of proctored exams.
Our readers really like Santa Fe. You voted it one particular of the friendliest cities in the U.S. , and one of the greatest cities for meals lovers Santa Fe also serves as each New Mexico's political and creative capital: Wander its wide streets flanked by adobe houses, and you'll commence to see why artists like Georgia 'Keeffe were so inspired by this eclectic and historic town. Check out the country's oldest church, San Miguel Mission, and dig into African comfort fare at Jambo Café or green chili enchiladas at The Shed.


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text:
Andrew C A Jampoler (1)
C Herbert Gilliland (1)
(-) Dennis J Ringle (1)
Edited by Paul Stillwell (1)
Edward L Beach (1)
(-) Edward L Beach Sr and Edward L Beach Jr (1)
Elizabeth R P Shaw (1)
Louis Arthur Norton (1)
(-) Ms Elizabeth R Shaw (1)
Beside Me Still
A Memoir of Love and Loss in World War II
By Elizabeth R. P. Shaw
Here is a compelling portrait of the other side of war—hose who must wait at home, uncertain what the Fates will decide—and Elizabeth Shaw knows this side of war all too well. She waited first for one husband, VanOstrand Perkins, who was killed in battle in the Pacific, and then another, James Shaw, who ultimately survived. This is a story ...
Life in Mr. Lincoln's Navy
By Dennis J. Ringle
Every aspect of the common sailor's life in the Union navy—from recruiting, clothing, training, shipboard routine, entertainment, and wages to diet, health, and combat experience—is addressed in this study, the first to examine the subject in rich detail. The wealth of new facts it provides allows the reader to take a fresh look at nineteenth-century social history, including issues like ...
From Annapolis to Scapa Flow
The Autobiography of Edward L. Beach Sr.
By Edward L. Beach Sr. and Edward L. Beach Jr.
Fans of Edward L. Beach Jr.'s books, including his classic submarine novel Run Silent, Run Deep and his 200-year history of the U.S. Navy, will be drawn to this memoir by his late father, a U.S. Navy Captain, who was a popular novelist of his era. Not only was Beach Sr. a good storyteller but he also was an astute ...


RUSD Board President Patricia Lock-Dawson was honored to be named the 2018 Art Pick Distinguished Alumna of the Year by Leadership Riverside, a Greater Riverside Chambers of Commerce program for seasoned business leaders.
Lock-Dawson was noted by the Chamber for championing a number of environment and education initiatives and serving on multiple boards (including RUSD) and advisory councils. She is passionate about how the power ofeducation helps transform the lives of individuals and communities, as well as preserving the quality of life in Riverside and the region.
At the ceremony, Ramona High Principal Victor Cisneros graduated from the 10-day Leadership Riverside program.


text:
Adult & Contemporary Romance
4.34 (53,063 ratings by Goodreads)
Dark-Hunter Novels
By (author) Sherrilyn Kenyon
Available. Expected delivery to the United States in 6-9 business days.
Bride McTierney has had it with men. They're cheap, self-centered, and never love her for who she is. But though she prides herself on being independent, deep down she still yearns for a knight in shining armor.
She just never expected her knight in shining armor to have a shiny coat of fur...
Deadly and tortured, Vane Kattalakis isn't what he seems. Most women lament that their boyfriends are dogs. In Bride's case, hers is a wolf. A Were-Hunter wolf. Wanted dead by his enemies, Vane isn't looking for a mate. But the Fates have marked Bride as his. Now he has three weeks to either convince Bride that the supernatural is real or he will spend the rest of his life neutered--something no self-respecting wolf can accept...
But how does a wolf convince a human to trust him with her life when his enemies are out to end his? In the world of the Were-Hunters, it really is dog-eat-dog. And only one alpha male can win.
Dimensions 106.68 x 173.23 x 26.67mm | 176.9g
Publisher St Martin's Press
Edition Statement Repr.
Time Untime
Fantasy Lover
Seize the Night
Sins of the Night
Night Pleasures (Dark-Hunter Novels)
One Silent Night
Styxx
Kiss of the Night
Dance with the Devil
Son of No One
Dragonbane
Dark Bites
Dragonmark
Dragonsworn
PRAISE FOR AUTHOR SHERRILYN KENYON
Kenyon is the reigning queen of the vampire novel.--Barbara Vey, Publishers Weekly
An engaging read.--Entertainment Weekly on Devil May Cry
Kenyon's writing is brisk, ironic, sexy, and relentlessly imaginative. These are not your mother's vampire novels.--The Boston Globe on Dark Side of the Moon
"[A] publishing phenomenon...[Sherrilyn Kenyon is] the reigning queen of the wildly successful paranormal scene.. . .Just one example of arguably the most in-demand and prolific authors in America these days." --Publisher's Weekly
"Kenyon's writing is brisk, ironic and relentless imaginative. These are not your mother's vampire novels." --Boston Globe
"[An] engaging read." --Entertainment Weekly
About Sherrilyn Kenyon
In the past two years, New York Times bestselling author Sherrilyn Kenyon has claimed the #1 spot twelve times, and since 2004, she has placed more than 50 novels on the New York Times list. This extraordinary bestseller continues to top every genre she writes. With more than 23 million copies of her books in print in over 30 countries, her current series include: The Dark-Hunters, The League, Lords of Avalon, BAD Agency, Chronicles of Nick and Nevermore. A preeminent voice in paranormal fiction, Kenyon helped pioneer and define the current paranormal trend that has captivated the world. She lives with her husband, three sons, a menagerie of animals and a collection of swords.
5 53% (28,174)
3 12% (6,604)
2 2% (1,088)
1 1% (425)
Review Courtesy of April Hollingworth The Dark Hunter series is one of beauty and danger. Where passions run high and the fight to survive and love, is the ultimate goal. Night Play is the 6th book in this wonderful series but is also the 1st book in the Were-Hunter series. A must read. Sherrilyn Kenyon brings you into her world, a place you can't help but care for those who reside in it. Opening Scene: Gennisi Come with me, modern traveler, back to a time that has been shrouded by mystery. The Review: Sentenced to death by a father who hates him,Vane survives against all odds. Upon a chance meeting of Bride, he can't help but feel vulnerable for the first time. When he realises that this beautiful woman is his destined mate, Vane realises he will do anything to keep her safe, even if it means losing her for ever. Bride is furious, her now ex-boyfriend of five years has dumped her by fed-ex, to rub salt into the wound he charged it to her account. Upon meeting the gorgeous Vane, she can't understand what he sees in her. After all if her ex couldn't love her because she was fat how can this adonis of a man love her? But danger is stalking the streets of New Orleans. With time running out Vane needs to convince Bride to trust him to keep her safe, but with his enemies out to kill him this is no easy task. And how can how can he expect a human to ever love a wolf? Notable Scene: He deftly fastened the necklace. His fingers lingered at her neck for a minute before he met her gaze in the mirror and stepped back. "Beautiful," he murmured huskily, only he wasn't looking at the necklace. He was staring into the reflection of her eyes. "I'll take it."show more
by April Hollingworth


The Daly City Police Department deploys two vehicle mounted Automated License Plate Readers. The license plate, registration history, and geographical location information are downloaded to a server housed and maintained by the Northern California Regional Intelligence Center (NCRIC). In compliance with SB 34 the following link will take you to the policy of the NCRIC. The Daly City Police Department's policy can be found here.


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Home >> The-grocers-encyclopedia-1911 >> Puff Ball to Yeast >> Snails
snail, spring, imported and grey
SNAILS. The edible land snails consumed in large quantities in France and several other European countries, present a considerable diversity in size and appearance. The most highly esteemed are the Helix Pomatia, locally known as the Burgundy, Large White, Roman, Vineyard, etc., with shells varying from greyish-yellow to grey ish-red and with irregular black markings, the latter in some cases completely covering the shell. They are gathered in vineyards and also raised in Snaileries or Snail Farms —patches of moist clayey ground, suitably fenced or separated by little water canals, and provided with bushes or high plants for protection against the sun, shaded pools of water and, frequently, low sloping wooden "shelters." They are fed principally on lettuce and other green stuff, but fruit and aromatic herbs, such as thyme, may also be included in the diet to give a special savor to their flesh. The creatures are prolific, each giving in the spring from 50 to 60 eggs.
Next in importance to the Large White, is the "Black Mouth," much smaller but also of very good flavor.
The common snail of the garden, woods, etc., consumed chiefly by the poorer classes, is commercially classed as the Small Grey. It is generally grey, with faint markings, but is also sometimes a full yellow.
The Snail Market plays an important part in the food supply of Vienna during the Lenten season, large quantities of "Swabian Snails" being imported from Wur temberg and other parts of S. W. Germany, but Paris is the best customer of the
collector and breeder—an average of 80 millions a year being sold in its principal markets, the Halles Centrales, alone.
Snails are for market purposes graded according to variety, size, etc., and packed in baskets, bags and casks. The two principal seasons are the spring and winter. The former is supplied largely by itinerant gatherers of the "wild" snails which show themselves freely after spring showers. The fall and winter supply, the last-named generally bringing the highest prices in Paris, is of snails (from snaileries and else where) which have sealed themselves up for the winter—which explains the appar ently "dried" condition of the fresh imported snails received here.
The American consumption has noticeably increased during the last few years. In some parts, native snails are caught and marketed, but preference is generally given to the European product, imported both fresh and canned, to a yearly total of $50,000 and upward. They are prepared in numerous ways—generally with liberal additions of herbs, spices and wine—and are considered a delicacy by many people.
From "The Grocer's Encyclopedia" by Artemas Ward (1911)


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