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Box office: Fate of the Furious to speed into top spot
Joey Nolfi
By Joey Nolfi April 12, 2017 at 05:03 PM EDT
The Fate of the Furious (2017)VIN DIESEL as Dom
Credit: Universal Pictures
Smurfs: The Lost Village
The Fate of the Furious is in pole position.
Universal is releasing the eighth installment in its high-octane, auto-centric action series as the widest North American, non-summer release in its history, pushing the ensemble blockbuster to a staggering 4,311 theaters this Friday. With no other new wide releases revving their engines this weekend, the film will handily cross the finish line in first place, but how much of an impact will it have on solid holdovers like The Boss Baby and Beauty and the Beast?
Check out EW's April 14-16 box office estimates below.
1. The Fate of the Furious – $120 million+
There's no question F. Gary Gray's take on the beloved Vin Diesel-fronted franchise — which launched 16 years ago — will burn rubber at the top of the domestic chart in the days ahead. Just how high will it go, though? Since 2001, with the exception of Tokyo Drift, each of the Fast and the Furious films have stacked opening grosses higher than their respective predecessors, ballooning to the most recent installment's $147.2 million debut in 2015.
While F8 is tracking below that number, it's still pacing to bag over $110 million. Most of its business will pour in from international markets, as Furious 7 netted almost $1.2 billion from foreign territories, making it the sixth highest-grossing film (unadjusted for inflation) in history. Day-and-date with its U.S. premiere, F8 drives into 63 territories at over 20,000 locations in China, the U.K., Mexico, Brazil, Australia, Russia, and more, priming it for one of the year's top global openings thus far.
2. The Boss Baby – $14.5 million
The reigning box office champion (that no one saw coming, mind you) heads into its third go-round on Friday, holding on a little stronger than usual as an effective, family-friendly counter to F8. Look for The Boss Baby to be demoted to $13 million-$15 million through Sunday.
3. Beauty and the Beast – $12.5 million
Disney's live-action adaptation of the beloved animated classic will finally cross the $1 billion mark by the end of this week, as its current global total stands at $986.4 million after just 26 days in theaters. The Bill Condon-directed fantasy stars Emma Watson and Dan Stevens as the titular couple nearly 16 years after the original became the first animated film to nab a Best Picture nod from the Academy. While such lofty awards season prospects might be a bit out of the retelling's reach, the film is a legitimate hit with audiences and will finish its theatrical tenure as one of the studio's best performers of all time. After a red-hot run, expect Beauty and the Beast to hold steady in the top three this week, cooling off in the $11 million-$14 million range.
4. Going in Style – $7.5 million
Mature audiences turned out last week for Zach Braff's latest directorial effort, about three older men (Oscar-winners Morgan Freeman, Michael Caine, and Alan Arkin) plotting revenge-fueled bank heists, and they'll probably do it again over the impending three-day frame — if historical trends repeat themselves. The older crowd tends to spread itself out over several weeks versus flooding theaters over opening weekend, typically resulting in the low launches posted by the likes of Hope Springs ($14.7 million opening, $63.5 million overall in 2012) and Florence Foster Jenkins ($6.6 million opening, $27.4 million overall in 2016). Look for Going in Style to take a soft tumble over its sophomore run.
5. Smurfs: The Lost Village – $7.4 million
Following its middling first weekend gross last week, the third in Sony / Columbia's reimagined line of Smurfs movies should shed around half of its inaugural audience, likely sputtering out in the coming weeks as a lower-priority holdover in the wake of buzzier family films (The Boss Baby, Beauty and the Beast).
Outside the top five, Chris Evans' family drama Gifted — about a protective uncle who tries to forge a normal life for his niece, a child math prodigy — expands this week, seemingly getting a head start on Fate of the Furious as it hits theaters nationwide Wednesday. Fox Searchlight did not respond to EW's request for an exact theater count, but it is expected to play at roughly 1,000 sites, according to Box Office Mojo. Having averaged a respectable $7,971 in limited release last weekend, expect Gifted to pull in around $3 million-$5 million in the coming days.
Hilary Swank, Susan Sarandon, Jessica Biel, and Patrick Stewart head to the box office this weekend as well, having lent their voices to the animated comedy Spark, which is poised for a modest tally at approximately 350 theaters.
On the specialty scene, James Gray's The Lost City of Z bows at four theaters, hoping to attract the prestige crowd that has catapulted Gray's previous offerings to solid limited openings (The Immigrant earned $14,688 per screen in 2014, while Two Lovers averaged $13,569 in 2009) in the past. The 2016 New York Film Festival closer stars Charlie Hunnam as British Lieutenant Colonel Percy Fawcett, an explorer who went missing in 1925 while searching for a lost city in the Amazon.
Kelly Asbury


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"Countdown to UFC 107" Debuts Tonight on Spike TV
Don't forget to check out the debut of "Countdown to UFC 107" on Spike TV tonight at 11PM ET/PT. The show will provide exclusive coverage of lightweight champ BJ Penn training in Hawaii as he prepares for this Saturday's fight against Diego Sanchez.
The camera crew will also follow Sanchez around the mainland as he preps for the biggest fight of his career. The final segments of the show will be dedicated to the heavyweight matchup between former two-time UFC champion Frank Mir and Cheick Kongo.
The show will highlight the UFC's final pay-per-view event of 2009, which will be jumping off inside the FedEx Forum in Memphis, Tennessee this weekend.
Penn has been the class of the division since returning to it a couple years back. He has rolled off four consecutive wins at lightweight, all ending in finishes, en route to capturing the title. He was last seen schooling a talented Kenny Florian at UFC 101 in August.
Speaking of winning four straight, Sanchez will be rolling into the Octagon with that same streak. Although he has been one of the UFC's toughest and most successful competitors, this will be his first 5Round affair. However, you can't really blame "The Ultimate Fighter 1" winner as he has fought in three different UFC divisions.

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Ola to launch cab service in London
By Wheelers Desk
Varun Singh
Ola has been granted a private hire vehicle operator license by Transport for London. The ride-hailing firm entered the United Kingdom (UK) in August 2018 and currently, there are more than 10,000 drivers registered on its platform in the country.
Not only has Ola been steadily expanding its presence across the UK, but it is also the only platform in the country to offer both private hire vehicles and black cabs. The grant of license will allow Ola to introduce its services in London, which has a population of over 8 million people.
"London is one of the world's most iconic cities and hosts a progressive mobility environment. We couldn't be more excited to bring Ola to London in the time ahead!" Ola spokesperson said in a statement.
While Ola is already one of the largest transportation platforms in the UK, it aspires to operate across the country from the biggest cities to towns with less than 3 lakh population.
"We are looking forward to building world-class mobility offerings for London, by collaborating with drivers, riders, the government and local authorities. Londoners will hear more from us closer to our launch in the city, as we get ready to serve them," the spokesperson said.
Renault to export MPV Triber to neighbouring countries
Audi A6 2019 gains a base four-cylinder engine
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CFMoto India launch delayed
Jaguar confirms electric XJ


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Charles Barnett (September 23, 1954 – March 16, 1996) was an American comedian and actor.

Life and career
Barnett was born in Bluefield, West Virginia. He first made a name for himself in the late 1970s and early 1980s, performing several shows of raunchy comedy a day at outdoor parks in New York City, most notably in Washington Square Park. In September 1980, Barnett auditioned for Saturday Night Live. Producer Jean Doumanian was ready to hire him; however, Barnett was self-conscious about his poor reading skills and he skipped a follow-up reading. His spot in the cast was ultimately given to Eddie Murphy.

Barnett was reportedly envious and resentful of Murphy for several years, although in 1983 he told Jet magazine, "Now that I'm making it, I watch Saturday Night Live every Saturday."

Barnett went on to appear in film and on television.  In the 1983 comedy film D.C. Cab, he played the role of Tyrone, one of the main characters who begins and ends (after the credits) the movie.  He had a recurring role on the hit 1980s TV series Miami Vice as Neville 'Noogie' Lamont. He appeared on Def Comedy Jam in 1993. Although the episode was not aired on TV, the DVD release of Def Comedy Jam contains an extra DVD with "2 Raw 4 TV", which has a Barnett performance. His last film role was in 1996 in the film They Bite. He died that year at age 41 from complications from AIDS due to intravenous drug use.

Select filmography
They Bite (1996)
Mondo New York (1988)
Nobody's Fool (1986)
Beer (1985)
My Man Adam (1985)
T.J. Hooker (1982-1986)
Miami Vice (1984–1989)
D.C. Cab (1983)

References

External links

1954 births
1996 deaths
Male actors from West Virginia
AIDS-related deaths in New York (state)
African-American male actors
American male film actors
American male television actors
People from Bluefield, West Virginia
20th-century American male actors
20th-century African-American people

redpajama_set_name: RedPajamaWikipedia


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redpajama_set_name: RedPajamaGithub


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Ras Al Khaimah wants to break a World Record with a 12-minute firework display
Ras Al Khaimah: 12-minute long firework display on Al Marjan Island
Published: December 10, 2018 12:11 Yousra Zaki, Web Features Editor
Al Marjan Island will try to break the Guinness World Record Image Credit: Supplied
This New Year's Eve, Ras Al Khaimah will host a 12-minute firework display as well as many family-oriented activities at Al Marjan Island.
The fireworks display, will be another bid for a Guinness World Record. This year there will be three additional viewing areas at Al Marjan Island and Al Hamra Village including Al Shohadah Street, Al Marjan Island and Al Wasl Street between Al Marjan Island and Al Hamra Village
Other features of the big event include food trucks, ice cream salons, lemonade corners, musical band performances, and children's activities such as face painting and inflatable games. Stilt walkers, mime artists, and clowns will welcome guests with free balloons to be distributed.
For easy access, the three venues to watch the fireworks have all been equipped with special parking areas, including 27,000 parking spaces. These venues are open for free to the public and are family-friendly with the festivities going on from 5pm on December 31 to 2am on January 1.
There will also be extra buses from Al Hamra, Mina Al Arab and the Ras Al Khaimah city to the venues.
Abdulla Al Abdouli, Managing Director & CEO of Marjan, said: "We made sure that this year we offer exciting family activities that will delight all, in the run-up to the amazing fireworks display. The event will position the Emirate as the must-visit destination this season. We have formed a special committee to oversee all aspects of the event to make it the most memorable to date."
Location Al Marjan Island by Marjan
Cost Free
Timings December 31, 2018 from 5pm onwards
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The 2nd PMB Meeting held in the Metropolitan City of Bari.
Traveling to Kerkyra Island for the kickoff meeting held at Faliraki Conference Center.
Three work groups organized, meetings and interviews with farmers took place.


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Famous Dex Charged With 19 Counts Including Gun Possession, Domestic Violence – Report
C. Vernon Coleman II Published: March 28, 2021
Prince Williams, Getty Images
Famous Dex has been hit with a slew of charges.
The Chicago rapper now faces 19 counts including gun possession and domestic violence stemming from three incidents that occurred in 2020, according to a TMZ report published on Sunday (March 28).
As previously reported, last November, Dex was the suspect in a domestic violence case where the SWAT team was called to his home after receiving notice that the rapper was armed and hurting his then-girlfriend. Dex's ex-girlfriend reportedly had cuts on her body when police arrived on the scene. However, the rapper had left before they arrived. Police have reportedly charged the rapper with domestic violence, weapon possession, dissuading a victim from reporting a crime and defacing property in that incident.
Dex reportedly faces more charges in a previous domestic incident with the same womAn that allegedly happened in October 2020. In that case, he has been charged with illegal possession of a firearm, exhibiting a firearm, inflicting bodily injury, dissuading a victim from reporting a crime, corporal injury domestic violence, threatening a domestic partner and defacing property.
Earlier this month, Dex was arrested for gun possession. In that case, he's been charged with possession of a firearm without a serial number and possessing a firearm despite having a restraining order against him.
XXL has reached out to Famous Dex's camp for comment.
It's been a tumultuous last few years for Dex, who has struggled with addiction. After fans expressed concern for the rapper last December when he posted some troubling videos online, he reportedly entered into a rehab facility earlier this year. He released his most recent solo project, Diana, last October.
See 21 Hip-Hop Projects That Fans Were Really Excited About But Never Happened
Source: Famous Dex Charged With 19 Counts Including Gun Possession, Domestic Violence – Report
Filed Under: Famous Dex
Freddie Gibbs Goes on Joe Rogan's Podcast After N-Word Controversy, Says Rogan Isn't Racist – Watch
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The groomer is well-equipped to handle any fur-related disaster with an armada of dog brushes, but who's to say what tools work best for your dog's coat when YOU'RE the one doing the work? More coat brushes exist than you might think possible, but there are an equally vast number of coat types out there to match! And all that fur is finding its way onto your clothes and into your coffee cups—consider it a fashion statement. A secret ingredient, if you will.
Shiba Inus blowing out their coats, Goldendoodles getting tangles, and Pit Bulls leaving their tiny hairs on everything you own all have a brush meant just for them—take a look at this simple guide to find exactly what you need.
When we remove the loose, dead hairs from the undercoat, they don't end up everywhere else. It's not a bad idea to give your dog a good brushing once or twice a week, or more during season changes when shedding tends to be heavier. The FURminator even ejects the hair directly from the brush so there's no manual removal necessary.
Slicker brushes are characterized by their super fine wire bristles. They're flexible and pointy to the touch, and suitable for detangling or removing light mats from most coats. When brushing your dog it's most effective to use short strokes rather than pulling it through the fur from head to tail; it's much gentler this way (no tugging on tangles) and makes short work of tough knots.
This self-cleaning brush from Hertzko even has a button that pulls in the bristles so you can easily wipe the hair away. Try pulling the fur out yourself from pointy slicker brush bristles and you'll realize pretty quickly why this is such a great feature.
Pin brushes are a lot like our everyday hairbrushes. They typically have rubber or plastic-tipped bristles and are great for getting through medium to long coat lengths or especially curly hair (think Poodles or Portugese Water Dogs).
The Safari wire pin brush is available in small-medium and large sizes and has an easy-to-grip handle.
We're looking specifically at the darker bristle side of this brush, though Safari outdid themselves with the convenient double-sided design. Bristle brushes are awesome for all coat types, but you'll want to pay attention to the length of the bristles and the wideness of the spaces between them to best suit your dog's hair length.
Generally, the longer and further apart the bristles, the longer the coat. And the shorter and closer together the bristles, the shorter the coat.
Undercoat rakes are fantastic for getting down into your dog's undercoat and removing loose or dead hair. This is especially important to keep fur detangled and prevent painful mats from forming. Rakes are best for medium to long haired pups, particularly for dogs like German Shepherds, Huskies, and Golden Retrievers with their thick double coats.
The stainless steel pins on the Pet Republique undercoat rake are designed to be gentle on your dog's skin while moving easily through hair.
Unlike a straight-pin rake, this tool has curved blades with rounded edges to gently work through knots and mats without damaging skin. It's the one tool I don't think I could live without with my double-coated dog. Even without mats present, it does an amazing job of getting through her thick undercoat and removing any tangles there.
This rake is good for most breeds, though you will want to avoid using it on dogs with very thin coats.
Even short-haired pups need some light grooming now and then. Shedding blades are perfect for removing loose hair from dogs like Beagles, Boxers, Corgis, and Labradors, and get the job done with only light pressure against the coat.
This blade from Safari is double-sided and can be used as a straight or curved blade—you can remove and reinsert it safely from the handle.
The ZoomGroom by KONG has quite a few loyal followers who praise it for removing loose hair, massaging shampoo into the coat at bath time, and even entertaining their dogs as a toy. Its blunt rubber bristles catch any free-floating hair and "stimulate capillaries and natural oil production," as KONG claims. As of yet, not many disagree.
My favorite use for this "brush" is working up a lather in the tub and getting the shampoo deep into my dog's coat. By the look on her face, it doesn't feel too bad either.


Your logo rarely stands alone— it needs supporting elements like colours, imagery, typography to create a cohesive brand look and feel. You will use all of these elements across your website, packaging, brand collateral and promotional materials and so, whether you are DIYing or working with a designer, it's really important to have these outlined. While we never say never, in most cases, we'll recommend creating a visual identity instead of just a logo.


Coming Clean - Kellbot! | Kellbot!
Commenter Tim asked how I keep the house so clean, especially in light of having a baby.
I'll tell you: I cheat. I almost always do a quick pick-up of a room before taking a photo, and usually only even think to do a house-related post when the house is in a semi-presentable state. In my most recent weekend-update, I'd just vacuumed the room because installing the window blinds left a fine layer of dust and metal shavings everywhere.
I'm proud of the fact that it's still not too terrible, and our overall level of house cleanliness is decent. Keeping the house in order takes a lot of work, but is crucial to keeping our overall stress level down.
Have a place for everything, and don't buy anything you don't know where you'll put it. I'm a sucker for kitchen gadgets, an affinity RD does not understand, but I'm allowed to buy whatever stupid kitchen items I want provided I can find a place to put them away.
Open sink policy – meaning no dirty dishes are left in the sink ever for any reason. Every now and then I backslide on this, but it works pretty well. Dirty dishes are washed immediately and set on the drying rack. We do have a dishwasher but we only use it when we have company over or I want to sterilize the baby bottles.
Daily chores. Cleaning a little each day is SO much easier than letting things pile up and then having to set aside an entire afternoon to dig out your living room floor. I had a page-a-day cleaning calendar at the old place, and need to update it for the new place.
The last secret is that I have help. RD's aunt comes for a few hours each day so I can work (I do freelance WordPress development), but the truth is about half that time gets spent on household chores. I can get some done while Bitmap naps, but having someone occupy her for a couple hours so I can take care of things is amazing. When people ask if I miss living in New York, I think about all the extra help I get by living near so many family members and the answer is unequivocally no. I might miss a few aspects of it, particularly my friends, but I am so very glad we moved down here when I got pregnant. My own parents didn't get their first night out sans-baby until I was 5 months old. Bitmap is 3 months now and I've lost count of the number of dates we've had thanks to my in-laws. Family FTW.
Ah ha! 🙂 That makes me feel better. And you know, that's a happy level of clutter. Feels homey/ lived-in.
I try to take care of all dishes before bed that may have accumulated during the day. I'm a believer in having a fresh start every morning.
So, admitingt to a little jealousy.. The family situation you have there is pretty amazing. Our son is almost 13 months old now, and we've been on two dates. We recently decided we need help, and have someone coming over twice a week, starting today actually. Hopefully soon that will extend to some evenings!
If I really wanted to be honest about clutter, I'd show you a picture of my office. But I'm pretty sure the world's not ready for that.
I know we are incredibly lucky to have the family situation we do. And even so, admitting I needed regular help with the baby was tough for me. I spent a lot of time feeling like I "should" be able to manage on my own, because plenty of other parents do. But once RD went back to work I felt incredibly jealous of him. His aunt is a kindergarten teacher and off for the summer, so things worked out perfectly in that regard.
I still feel a little guilty that pawning my kid off on someone else for a few hours is necessary for my sanity, but I'm slowly getting over that.


The investment in quarterback is the biggest investment a team makes. A mistake in judgement often sets a team back three years if not more. Teams usually get stuck chasing the potential of a player and the sunk costs of the contract. This was one of the big reasons for the push in the last CBA negotiations to eliminate the uncapped rookie systems. Teams would be stuck with big money players, typically quarterbacks, eating large percentages of the salary cap and budget who were failures. But teams would chase that investment trying over and over again to find a way to make it work. That is really the heart of the matter when looking at a contract offer for Kirk Cousins.
The league is filled with teams who have made the mistake of giving too much weight to one good season and the hope of potential. Ryan Fitzpatrick getting his big contract from the Bills after a few "hot" games in 2011. Matt Cassel hit gold with one season in New England. Jake Delhomme was once a big winner in Carolina. The 49ers are stuck in limbo with Colin Kaepernick. Even players with varying degrees of success like Jay Cutler, Chad Pennington, and Mike Vick clogged team's salary caps and roster decisions for years based more on potential and a flash of being good than anything else.
The Redskins are right for looking to avoid getting stuck in those situations. If you look at Cousin's history we have one good season and three seasons essentially as a benchwarmer and poor spot starter. He doesn't even have the higher draft pedigree to fall back on. A team has to have a lot of faith to fork over $20 million per year on a long term deal based on that.
How difficult is it to produce in that short run in the NFL? Here are a few names that popped into my head and a seasons worth (except for Nick Foles since he had two partial years) of numbers that landed them a new deal.
Freeman was the only player on that list who completely flamed out before he would receive a second contract. The others were able to land decent deals and in each case the team was ready to move on within a year of signing it.
You could limit this list further if you wanted by taking out some of the bottom names or higher draft picks that happened to see some bench time, but this should at least give a decent overview of the considerations on the Redskins end.
For some of the names the jury is still out but may look dim (Griffin, Kaepernick), but I think if we do a quick estimation I would say about 50% of the names ended up as backups level players, 15% came across as spot starters, 15% were average and 20% ended up above average.
If you took used those numbers to really generate the risk of the signing you would come out with something like this using the current salary ranges in the NFL as our tier baselines.
That basically means any offer over $8 million a season is a risk for the Redskins. The $8 million number gives an equal risk and reward for the four ranges of outcomes.
Now I think we all know that Cousins is not signing for that little (the Redskins have reportedly gone to $15M in their offers) since he is coming into free agency hot unlike a RG3 who is coming in ice cold. Let's limit the pool to eliminate the lower backup levels since Washington, by engaging in talks for this type of contract, has already decided that they will take on the risk of assuming he is going to be a starter even if its of the high level backup variety like a Ryan Fitzpatrick or Josh McCown.
Here we get a max number of $14.2 million per year, which is more in line with what Washington offered. Again by going over this number they are assuming a bigger portion of risk in the contract than Cousins. $15 million is certainly a fair offer (unless structured very strangely) and Washington should not go much higher than that if they want to limit their risk in this investment.
If they can't come to an agreement, if I were the Redskins I would probably use the transition tag on Cousins. That number will be around $17 million and be in the range of expectations for a season. Could he sign an offer elsewhere? It is possible but at least it lets a market decide how much risk they will absorb to sign a player like Cousins. The Redskins are not in danger of losing him because of frontloaded contract structures so that is also not a worry like there would be with other teams who might have cap problems.
If Cousins is firm on looking for a $20 million a year contract then there is almost no risk for the Redskins in using a tag this season. Unlike other positions, quarterbacks last long after they are 30 so losing out on one contract year is not as big of a deal as it would be on other positions where the returns begin to diminish so quickly. Though Andrew Luck is soon going to be due a new contract the market at the top is so bunched up than even if Cousins played out of his mind he wouldn't earn more than $22 million. So if $20 million is the number there is not much more he can gain by playing it out.
There is, however, far more risk for Cousins. If Cousins was to take a $15 million per year contract I would guess he would earn somewhere around $32 million over the next two years and would be likely to reach $45-$48 million over three years. If he flames out on a franchise tag he will earn far less because of the steep price drop between a starting quality player and a high end backup.
In that scenario he would probably earn $19.5 million in 2016 and then drop all the way down to $6 million in 2017, and possibly less in 2018. Considering there is more of a likelihood in this scenario I'd estimate that the earning potential here is $26 million over two years and $31 million over three. That's a far cry from a $15 million per year offer.
So once Washington pushes over the $14 million a year number Cousins really needs to think hard about accepting such a contract. While I am sure he is very confident that he is a top quarterback, so were many other players before him that ended up having careers that never went past the contractual level of being signed to compete for a starting job on a bad team. It is a big bet on himself to aim for that $20 million a year contract if no team bites this season and he lands on a tag.
In the past I would have expected Washington to just pay him the $20 million but this is a new front office and one that seems to be playing it more by the numbers. If they are smart they will continue that same approach with Cousins over the next few weeks.
This entry was posted in Contracts and tagged kirk cousins, washington redskins. Bookmark the permalink.


The participants were a mix of researchers, curators, policy makers and representatives from funding agencies that are engaged, or have an interest, in the creation, use and management of digital data.
The conference was officially opened by Chris Rusbridge, Director of the DCC, who welcomed everyone to the event and encouraged attendees to ask plenty of questions and actively participate in the discussion sessions to make the conference as interactive as possible.
Graham Cameron explained the EBI's experience with biomolecular data and illustrated the remarkable enhancement to the conduct of science offered by shared curated databases. He illustrated the usefulness of biomolecular data to scientific communities by providing compelling data about the submission rates for primary research data and the global access to the EBI Web site (both of which are exponential in growth) . However, it is the integration of databases that now provides the greatest challenge. Graham stimulated discussion about long-established conventions in constructing and maintaining databases and repositories of biological data and concluded that the integrity of the conventional (printed) record is woefully inadequate in the electronic era.
Chris Rusbridge outlined the main objectives, membership, establishment and work to date of the DCC. It was explained that the DCC will not provide any data storage facilities but will focus on providing researchers with useful tools, advice and services which they will need to help them properly curate their data. Several projects from a variety of disciplines were described which highlighted the explosion in data generation that has occurred alongside the emergence of new technologies. Attention was drawn to the issue of long-term sustainability of databases and the need for the adoption of data policies by large-scale institutions and funding agencies. The issue of the scope of the DCC was also discussed. The importance of participation in the Associates Network was highlighted and a summary of future workshops and the launch of The International Journal of Digital Curation was also presented .
Should the definition of data curation encompass preservation and access strategies to data. Opinions differed but a clear definition, in terms of the remit of the DCC, will need to be agreed.
What data should be preserved? It will not be possible to preserve and/or curate all the data that is generated. Careful thought will need to be given to the strategies used to decide what data to preserve, these strategies are likely to differ between disciplines.
The issue of ensuring sufficient interaction between the data generators (domain experts) and librarians/archivists (preservation experts). What is the best way to do this? Is it realistic to expect people to have expertise in both? Training will need to be addressed alongside encouraging individuals with different expertise to work together.
How can we future-proof what is archived? We need to ensure that the technologies used currently are not obsolete in the future and that sufficient migration strategies are put in place and funded.
How do we achieve policy changes at the level of academic institutions and funding agencies? Data sharing policies, which encourage thinking about data preservation and curation at the early stages of project lifespan would be beneficial. The National Cancer Research Institute (NCRI) Informatics Initiative has generated a data-sharing policy  that is now being adopted by the top 20 cancer funders in the UK - how could this approach apply to other areas?
After a well deserved coffee break, the afternoon session dealt with "Global Policy for Curation" and was chaired by Richard Boulderstone, Director of e-Strategy at the British Library.
Stefan Strathmann provided the meeting with an update of the 'nestor' Project, funded by the German Federal Ministry of Education and Research . Along with organised workshops and conferences, nestor has or is due to deliver a number of expert reports regarding the German experience and approach to digital curation. These reports will form the basis of guidelines to stakeholders regarding digital preservation, translations of articles, future teaching materials and project glossary.
learn how to build and maintain partnerships that differ in both scope and nature.
The last session of the day was the poster session which preceded the hugely enjoyable conference dinner at the Roman Baths and Pump Rooms.
Day two of the conference opened with the issue of "Data Curation: A Question of Scale", which was chaired by Professor Malcolm Atkinson, Director, National eScience Centre.
Andy Lawrence described the imbalance in funding for IT in astronomy in that facility operations and facility output processing tended to be well funded whereas the science archives and end-user tools attracted less money. Astronomical archives are growing in size very quickly; however the issue is one of management and data access rather than storage. The amount of data itself is not a technical problem but the data is heterogeneous and end-users of the data have different demands. The astronomy field has recognised that the issue is one of interoperability of archives and there is a need for standards, transparent infrastructure and specialised data centres. To address this the Virtual Observatory is being established - the concept is one of all databases being easily accessible to the end-user. Rather than a warehouse it will consist of a small set of service centres and large populations of end-users. The International Virtual Observatory Alliance  has set up technical working groups to agree on the standards necessary and the key projects include AstroGrid, US-NVO and Euro-VO. This interoperability should drive future scientific developments in the astronomy field.
Kevin Ashley explained that this session would provide an introduction to the DSpace Project, which is providing a cross-disciplinary data archiving solution, as well as an overview to the technical and economic challenges that need to be considered with regard to the sustainability of data resources and the data they contain.
Mackenzie Smith spoke about the growing realisation that data management is an important issue for large-scale institutions to address, both to enhance research programmes and address the business need of data validation and mining in the future. The disparity between the approaches of different disciplines to the access to, and sharing of, data was discussed and the differing availability of large-scale repositories to support disciplines was also highlighted. The complex nature of research data was described, the tasks needed for effective curation and archiving and the need for an in-depth understanding of the subject were highlighted. The DSpace Project was explained  and the benefit of being able to store different data types in an open and interoperable way was described. It was explained that the preservation policy being adopted was that it is better to preserve what we can now and refine this as needs and technologies change over time. This is deemed to minimise the risk of losing data completely while trying to devise the 'perfect' solution.
Maggie Jones spoke about the challenge of effectively archiving and preserving digital collections as the pace of data generation grows ever faster. Maggie explained that a more collaborative approach will be needed to provide multi-disciplinary, cost-effective archiving solutions and that we should aim to manage data from its creation onwards. However, we need to take a pragmatic approach and Maggie echoed the approach of the previous speaker in preserving what we can now to minimise losing data. Several initiatives are now addressing key issues  . The future work-plan of the DPC was outlined, including the provision of targeted training courses, and attendees were encouraged to complete the DPC survey . This survey will identify, not only what is being created in digital format and how it is being preserved, but will assess the level of risk and vulnerability to loss, and determine priorities for action. The results will enable the DPC to accelerate, influence and inform the development of a UK digital preservation strategy.
Professor Kevin Edge chaired a session looking at how user requirements are being met in the digital curation age. This took the form of a panel discussion with Sheila Anderson, Professor Kevin Schurer and Mark Thorley on the panel. The discussion centred on a number of topics including what the main threats are in providing continued access to the research and teaching digital objects in a collection over time. The group discussed what could be done to minimise these threats. The role of research councils in supporting the preservation of and access to data was examined and how researchers or data creators could minimise the risk of data being lost, or being inaccessible in the longer term.
Legal issues surrounding data curation are complex. This is most generally a result of heterogeneous data, the ownership and custodian roles of researchers and curators and uncertainty of the responsibility of persistence and preservation of data. Much of the conference up until now had dealt with identifying a curator's role, identification of data to preserve and the programmes that have developed to address these issues. This session dealt with the curation of data in the context of copyright and access rights and how these issues were shaping the way data creators, curators and funders approach data preservation and reuse.
Andrew Charlesworth, Senior Research Fellow in IT and Law at the University of Bristol, spoke on the role of copyright law in data curation. Andrew noted that recent events had led to increased expectations and influence of rights holders and that this had generated a backlash, which considers copyright law to be over-strength, over-regulated and over-rated. The result of this backlash has been the emergence of open-source movements and Creative Commons where some copyright agreements exist but to a much lesser degree. Andrew then presented a Science Commons where standardised licences are voluntarily agreed but still manage to create areas of free access and inquiry. The major areas of this commons can be found in publishing, licensing and the use (or more correctly reuse) of data. Andrew suggested the copyright should be more focused on the researcher, the so-called 'researcher rights' but this required more clarification and was dependent on engaging the data creators and curators to work out what these 'researcher rights' should be.
Paul Taylor presented a case study of curation based on the e-Diamond Project, which aimed to deliver a prototype Grid-based image repository that could be used as a training tool in breast screening, epidemiology and data mining and would exemplify the utility of data reuse and added value . Paul introduced the breast-screening programme in the UK and provided an overview of why digitising and archiving mammograms would be beneficial for researchers, healthcare professionals and patients. Paul talked about the problems with ethical and consent issues which presented significant barriers to the project but suggested that the barriers were a result of both complex and bureaucratic ethics approval processes and the project team's under-estimation of their complexity. Paul concluded his presentation by summarising the significant output of e-Diamond, a valuable set of mammograms and a proof of concept for the value of Grid infrastructure for evidence-based medicine and research application.
Professor Peter Buneman chaired this parallel session which highlighted some of the research occurring in the field of digital curation. There was standing-room only for this well-attended session.
Dr Rajendra Bose introduced new approaches to annotation and described the relevance of annotation to digital curation. He firstly described the AstroDAS Project which built on the distributed annotation system (DAS) from the bioinformatics field (BioDAS). This prototype aims to link the annotated entries across diverse astronomy sky catalogues that correspond to the same sky object. The Mondrian Project was also presented - another model of annotation, it allows annotations of the associations between attribute values as well as the attribute values themselves.
How can the product, its design and the rationale behind the decisions be represented?
How can we capture the understanding of products and their impact on users throughout the product life?
How can the dynamics of knowledge use throughout the life cycle of complex product-service systems be managed and used to make recommendations?
Many of the issues described echoed the digital curation issues of other communities.
Professor Jane Hunter started by describing the PANIC Project  which aims to address the preservation and accessibility of composite digital objects using semantic Web services. Scientific data is organised into scientific models which encapsulate contextual information, processing steps and derived knowledge as well as links to the raw data itself. There was also discussion of the tools and services that might be needed as these scientific model packages evolve over time.
Dr Clifford Lynch provided an entertaining and informative overview of the conference and highlighted some of the key issues that had been raised. In particular, the rising importance of digital data in research, learning and teaching was emphasised and the need to adapt our institutional and individual practices to reflect this was highlighted. The need for a collaborative approach was reiterated and the usefulness of conferences such as this one, as a forum for discussion, was reinforced.
The conference ended with Chris Rusbridge thanking the speakers and attendees for their participation in what had proved to be a very enjoyable and informative conference. It is clear that a lot of work will need to be done to address the issues raised at the conference and that community participation is going to be key to making the DCC a success. We at the NCRI Informatics Initiative look forward to remaining involved, attending future events and monitoring the progress of the project.
Article Title: "Digital Curation: Where Do We Go From Here?"


text:
Making sense of Repeal feels; or trying to.
June 12, 2018 ·	by themotherhub ·	in Motherhood, Repeal the Eighth	· 4 Comments
There's a quote I've repeated to myself many times over the last few weeks, and it comes from an unlikely source. Those of you with young children may be familiar with the cartoon Daniel Tiger, and the wise oracle like figure of his mum. She has a song,
" Sometimes you feel two feelings at the same time, and that's OK."
It has become my mantra.
On the night of the referendum to repeal the eighth amendment, the Irish Times released an exit poll which indicated a landslide for Yes. I was in bed at the time and saw the news on Twitter, 'oh that's really great,' I thought and kept on scrolling. Given that the day had begun with me fighting back tears whilst I accompanied my husband to the polling station, and had continued on in that vein, my lack of emotion at this news was surprising to me.
As official results came in throughout the following day, it was clear the exit poll was correct, and Yes had won with a landslide. No one had allowed themselves to think this might be the outcome. We may have been hopeful of a yes victory, but only by a narrow margin. Perhaps this is why my feelings at the result were so unexpected, because the result itself was too.
In the weeks leading up to the referendum, like so many people, I found it increasingly difficult to think about anything else. I can't think of a time when I was so engaged in a campaign, can't think of anything I have ever been so emotionally invested in. Again, like so many other people, I pushed myself to do things I never dreamed I would, because I couldn't bear the thought of doing nothing.
On the Tuesday before the vote, on my commute into work I passed three 'Beep for Yes' stalls – I beeped my horn enthusiastically at each one, culminating with simultaneous sobbing as I reached the last one, just before I turned into work. I attended my daughter's graduation from Montessori on the afternoon of the vote, resplendent with Repeal and Yes merchandise. As I approached the building, I aw one parent recoil when she saw my badges, but was bolstered by other parents wearing their own 'I voted Yes' stickers. I assessed everyone I spoke to that day through the lens of their voting tendencies, were they 'Yes' or 'No.' I suddenly wanted to tell all my Irish, women friends how much I loved them. I felt the power of the Sisterhood strongly. I whatsapped my peer mentor group to tell them. I posted in Facebook groups to tell friends how amazing they all had been – writing, canvassing, campaigning, and how proud I was to be an honorary Irish woman on that day.
In short, I was feeling all the feels, on Friday 25th May. But in the days following the win, I felt what I could only describe as flat. Had I used up all my emotions in the preceding weeks? Was I made of stone? A no victory, had been inconceivable, and yet it seemed that any outcome at all was inconceivable , so focussed had we all been on the fight. Many women in Ireland have literally been fighting all their adult lives for this. How are you supposed to feel, when you get the thing you have been fighting a lifetime for?
Then, around ten days after that historic win, I was at the Mansion House, with many others to welcome home the Magdalene survivors. Women who had been treated cruelly by the state, for no other reason than tragically misplaced moral guidelines and Church controlled misogyny. Being part of a group of like minded people, coming to bear witness to these brave women, before the survivors even arrived, I could feel the emotions of the 25th May begin to surge again. Because, of course, the line between the Eighth Amendment and the Magdalene Laundries is so incredibly short.
Amongst the crowd, were many faces I recognised as Repeal campaigners, faces also that I had seen in Dublin Castle the day after the vote, celebrating Yes. I hesitated to write 'celebrating.' It's unseemly to celebrate Repeal, apparently, as if that isn't a blatant and wilful misunderstanding of what the campaign was all about. It was distilled as ' the abortion referendum', but it was never really just about abortion. It was about valuing women, trusting women, and acknowledging how awfully they had been let down by their country in the past. Any celebrating was tempered by relief, anger and sadness for those for whom the result came too late. Those same feelings were in evidence again at the Mansion House last Tuesday; joy at seeing these women finally receiving a welcome home from the country which had let them down so badly, anger that it had taken so long, that it ever happened in the first place, relief that at last, at last the veil seems to be lifting. Bit by bit, Ireland is telling the world, and its own leaders, who it wants to be. The conversations have started, the apologies are long overdue. There's no going back.
And it was there at the Mansion House, welcoming these women home, that the emotions of the last few weeks finally emerged. It felt like a release, for me. It feels like the beginning of an atonement. It feels new. I hope the women we were there to support felt it too; that we were all there for them, supporting them, apologising to them.
I hope I can remember the emotions of these last few weeks, in Ireland, even if I can't really make sense of them.
Tags: #repealthe8th, repeal, sisterhood, solidarity, yes
Wendy Armstrong (@Wendy_Armstro) · June 12, 2018 - 1:57 pm · Reply→
It was a very emotional build-up indeed.. I think it was so huge and historical, the thing, that it was normal to feel odd afterwards.
themotherhub · June 12, 2018 - 2:04 pm · Reply→
And so weird to be present at history being made. And being aware of it .
weavinglegends · June 12, 2018 - 5:08 pm · Reply→
Thank you for this. It sums up what so many campaigners and Repeal supporters have been feeling recently. What a draining time it has been for us all! ❤
fancypaperblog · June 19, 2018 - 7:45 pm · Reply→
It was a referendum that was so difficult to be in the centre of and clear as Day as to the right thing to do from the outside. I HATED the poster campaign on this occasion. It felt angry and intolerant alone without a word being said.
I am glad it is over, I admit, and glad of the result and feel we are still only making very small steps to a fully equal Ireland.
But we are stepping the right way.
← If we're going to talk about abortion regret, let's also talk about maternal regret.
Poem: Thirty weeks, almost. →


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text:
var EventEmitter = require('events').EventEmitter,
fs = require('fs'),
_path = require('path');

module.exports = walkdir;

walkdir.find = walkdir.walk = walkdir;

walkdir.sync = function(file,options){
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};

function walkdir(path,options,cb){

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    return emitter;
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}


text:
Publisher of Watchman Nee & Witness Lee
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The Genuine Ground of Oneness
The Genuine Ground of Onenessby Witness Lee
Printed Copy: Available Online from Living Stream Ministry
Chapter Table of Contents 1 2 3 4 5 6 7 8 9 10
Currently in: Chapter 9 of 10 Section 2 of 6
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NO REASON FOR DIVISION
According to Romans 14, there is no reason for Christians to be divided. However, most Christians are accustomed to the existence of high places. Some may even feel that today's high places are right and necessary. We think this way because we were born into an environment filled with division, with high places of every variety. Because we are so accustomed to division, we may have very little feeling about it. Paul's feeling in Romans 14, on the contrary, was altogether different. Here he encourages us not to argue over such things as eating or observing days. Concerning these things, we should refrain from expressing our opinion. In this way the oneness of the believers will be preserved.
In the previous chapter I referred to a joint meeting of Christian groups that was held for a while in Los Angeles in 1963. The members of these groups were eager to come together for the practice of the church life. Hearing of their interest and of their proposal to have a joint meeting, I gave them a word from Romans 14. I pointed out that if we intend to practice the church life, we must take the way set down by Paul in this chapter. Many Christians talk about the Body life in Romans 12, but they neglect the principles in Romans 14. Without Romans 14 it is impossible to have the Body life described in Romans 12. Throughout the centuries Christians have been divided by opinions over doctrine and practices. For example, Christians are divided over the matter of baptism. There is disagreement not only about the mode of baptism but also about the water that is used and the name in which believers are baptized. The opinions concerning baptism have caused many divisions, even many elevations that exalt a particular opinion. Therefore, it is of crucial importance that we follow the way exemplified by Paul in Romans 14. Those from these groups assured me that they would take this way.
Nevertheless, after just a few weeks, problems developed. Some insisted on playing tambourines and speaking in tongues in the meetings. Others strongly opposed these practices. Eventually, neither group was willing to give in and to care for the feeling of others in order to maintain oneness. Eventually, it was not possible for that joint meeting to continue. The ones in these groups expected everyone to be the same as they were. However, if we have such an expectation, it will not be possible to have the church life. The church life must be all-inclusive, able to include all manner of genuine Christians.
In Romans 14 Paul had no intention of taking sides on the questions of eating or of observing days. Instead, he said, "He who regards that day, regards it to the Lord; and he who eats, eats to the Lord, for he gives thanks to God; and he who does not eat, does not eat to the Lord, and he gives thanks to God" (v. 6). This was Paul's attitude, and it should be our attitude today.
We should not try to make everyone the same as we are. For example, although we may not speak in tongues, we should not forbid others to speak in tongues. On the other hand, those who speak in tongues should not insist that others do so as well. If we have this attitude, we will not be sectarian, and there will be no high places among us.
Some accuse us of narrowness. However, we are not narrow, for we receive all genuine Christians. The ones who are narrow are those who insist on a certain doctrine or practice. Their insistence on a particular matter causes it to be elevated and uplifted in place of Christ.
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text:
SNARED
A new drama. An age old conflict. A Smokescreen Visuals and Perf@ECT presentation
Seen the show? Please let us know if you enjoyed it and share any thoughts you may have about the issues it raised. Simply scroll down to the bottom of the page to leave your comments.
13 thoughts on "Audience Feedback"
Bill Gleave on February 26, 2013 at 11:10 pm said:
Very much enjoyed Snared. Really effective theatrical mix of video and live performance. The play considered a range of complex moral issues and was very well researched. Really stimulating discussion afterwards too. Excellent.
Oliver Parfitt on February 16, 2013 at 10:41 am said:
Wonderful show and well done to all the actors involved especially to Manny, as it was his first appearance on broadway afterall.
I found the show to be very thought provoking and emotionally charged. The use of the video backdrop was very powerful in producing a moving atmosphere and bringing the stage to life.
Well done to all concerned in the production of the play in getting the conservation message across to a wider audience. Even though Africa is not in our back yard, what happens there or anywhere else in the world for that matter, has an effect on us all though the impact may not be obvious at first.
They say time is a healer, but what the human race has done to planet earth has turned it against us. We cannot afford to turn a blind eye anymore. We must make a stand against the tyranny of destruction that is ravaging mother earth and the plundering of the innocent bystanders of both the people and creatures that live in harmony with her.
Diane Maxfield on February 15, 2013 at 10:37 am said:
Spent Valentine's Day evening watching a truly stirring production at the Yvonne Arnaud's Mill Studio – 'Snared'. Performances Friday 15 and Saturday 16 February at 8.00 pm. Tel 01483 440000.
A combination of live action and film, set in Zambia's beautiful Luangwa Valley, 'Snared' explores the complex issues around wildlife conservation. To a poor African villager an elephant is 'vermin'; to a British conservationist saving elephants is about the 'sanctity of life'. This is strong stuff and one of the most stirring and thought-provoking productions I have seen for a long time.
Brilliantly and movingly acted by Philip Poole, Victoria McManus and Manny Mvula; 'Snared' is very much about the painful truths and difficult decisions which must be made if we are to save what's left of the World's dwindling wild places and its animals.
As someone who has had the privilege of visiting Africa several times and been up-close and personal with its wildlife, as well as meeting people of all kinds involved in 'wildlife work'; I can recommend 'Snared' whole-heartedly.
Tracy Carby on February 15, 2013 at 10:33 am said:
Hi. Just to say well done for your performance this evening it was very thought provoking. I did go through many emotions whilst watching and afterwards.
Firstly afterwards my gut reaction was depression as I saw no hope for the wildlife in Africa. As an animal lover I hate to see any animal suffering including humans. I hate to see the exploitation of animals to satisfy human greed or twisted egos and understand the need of a local community to develop and protect their livelihood.
It is all a bit of a not in my backyard scenario as other countries have exploited their own resources to extinction so the humans can thrive and have what they want. But in Africa it seems the wildlife and resources are exploited but not to the benefit of the common people. A double whammy of bad. I am hoping that they will find there was life on Mars just like our own and it was destroyed by humans who obliterated the wildlife and the planet died. Perhaps then the people who aren't bad but do nothing will realise the options for the future are in their hands.
Perhaps if we restricted reproduction and all lived longer like 200 years we d care more and do more for the next generation.
In the meantime I think your play should be televised!
Tracy Carby
Animal Science Student
Canterbury College.
Keith on February 15, 2013 at 12:02 am said:
The talk back session was great, discussing the issues raised in the first half.
This was a rare opportunity to listen to the ideas and expertise shared between the audience and the special guests – wish more time was allowed for this part of the show to discuss in greater depth all the points raised.
Ian Redmond on February 14, 2013 at 10:49 pm said:
Dynamic and passionate exploration of the complexities of conservation in modern Africa – congratulations to all concerned for a deeply moving and thought-provoking performance last night in Canterbury.
Diogo Veríssimo on February 14, 2013 at 10:16 am said:
This play is an entertaining effort to stimulate a debate around wildlife management and trade, with the actors delivering largely convincing performances. However, as a conservationist, I feel that the script could be improved in several areas. The key to effective conservation is to have the support of local people, yet the script was completely focused on two foreign characters who believed they knew what was best for the wildlife of Zambia. This to my mind would resemble Zambian people taking a stance on badger culling or fox hunting in the UK. Also conspicuously absent was the lack of a focus on demand as a key part of wildlife trade which is the one key issue the audience could have had a direct impact in. I also felt uneasy about the way how, when talking about sports hunting for example, conservation and animal welfare issues were mixed, when they are indeed very different subjects, one focuses on species and populations the other on single individuals. Lastly, even as a conservationist, I was uncomfortable with the righteous rhetoric that was adopted to describe conservationists, knowing that conservation has been responsible for issues such as the displacement of communities or restriction of access to natural resources. Overall, and although I consider that it is always important to bring wildlife-related to the forefront, a more informed discourse around conservation could have been adopted.
Lucy on September 28, 2012 at 10:40 am said:
It was a good theatrical piece. The mix of stage and screen was very effective. The dynamics between the characters was well written .The idea of the hunter and the hunted being in the same cage is great metaphore . I agree with the above , more of Manny would give the play another dynamic ! Lots of food for thought though. Thanks
Caron Beaton on September 25, 2012 at 4:02 pm said:
Steph B on September 25, 2012 at 2:31 pm said:
THEATRICAL EASTBOURNE REVIEW: 22 September 2012 15:29. By Steph B.
Snared is primarily a strong piece of theatre, drama that happens to have a message, not a message with drama tacked around it. From the moment the charismatic Mangani appeared on stage, speaking directly to the audience, I was interested to see where we would be taken. I thought I knew my opinion on poaching vs conservation, but after the play and discussion yesterday, I am still thinking over the issues raised.
The single bush camp set has been well thought out and constructed and its sense of claustrophobia intensifies as the play progresses. The backdrop doubles as a film screen where film clips are cleverly interspersed with the live action onstage. My only gripe (and I accept that it is unfair considering the budget) is that one filmed scene was obviously shot rather closer to home than Zambia. I was particularly impressed with the slick use of sound effects which was effectively done to heighten tension and pace the drama.
All three actors convincingly portrayed their roles and avoided stereotyping, although some of their more impassioned dialogue was spoken fast therefore not so easy to hear. Hart and De Beers are rounded, complicated characters whose arguments flowed well and I am still finding it hard to believe that Manny Mvula is not a professional actor!
Steve Coveney on September 25, 2012 at 12:21 pm said:
I really enjoyed the play, it was very well written and superbly performed. My emotions were up and down as my loyalties went from the first character to the second then back to the first and so on. Very powerful and thought provoking, I would thoroughly reccommend to any body who has any interest in the preservation of African wild life
Tracey Doodney on September 25, 2012 at 11:31 am said:
A very thought provoking production. Could empathise with both sides of the argument, very powerful. Thoroughly enjoyed the show – wonderful perfomance from all actors
Mangani Bwalya Mwamba on September 25, 2012 at 12:08 pm said:
Thanks Tracey, we are hoping that we can stimulate a current issues debate along with raising awareness with our audience. We can't sit on the fence but it's time to grab the bull by its horns and hopefully steer it in the right direction for the health and benefit of all living beings. It may be hard for others to take, but we can't please everyone and so we just have to press on!!!


text:
Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with Bindarit, an inhibitor of monocyte chemotactic proteins
Nestor Rulli, Angelo Guglielmotti, Giorgina Mangano, Michael Rolph, Claudia Apicella, Ali Zaid, Andreas Suhrbier, Suresh Mahalingam
Alphaviruses such as chikungunya virus, Sindbis virus, o'nyong-nyong virus, Mayaro virus, and Ross River virus (RRV), are commonly associated with arthralgias and overt arthritides worldwide. Understanding the processes by which arthritogenic viruses cause disease is a prerequisite in the quest for better treatments. In this regard, we have recently established that monocyte/macrophages are mediators of alphavirus-induced arthritis in mice. We hypothesized that chemokines associated with monocyte/macrophage recruitment may play an important role in disease. The aim of the present investigations was to determine whether bindarit, an inhibitor of monocyte chemotactic protein (MCP) synthesis, could ameliorate alphavirus-induced rheumatic disease in mice.
Using our recently developed mouse model of RRV-induced arthritis, which has many characteristics of RRV disease (RRVD) in humans, the effects of bindarit treatment on RRVD in mice were determined via histologic analyses, immunohistochemistry, flow cytometry, real-time polymerase chain reaction analysis, enzyme-linked immunosorbent assay, and electrophoretic mobility shift assay.
Bindarit-treated RRV-infected mice developed mild disease and had substantially reduced tissue destruction and inflammatory cell recruitment as compared with untreated RRV-infected mice. The virus load in the tissues was not affected by bindarit treatment. Bindarit exhibited its activity by down-regulating MCPs, which in turn led to inhibition of cell infiltration and lower production of NF-kappaB and tumor necrosis factor alpha, which are involved in mediating tissue damage.
Our data support the use of inhibitors of MCP production in the treatment of arthritogenic alphavirus syndromes and suggest that bindarit may be useful in treating RRVD and other alphavirus-induced arthritides in humans
Arthritis Rheumatism
https://doi.org/10.1002/art.24682
10.1002/art.24682
Fingerprint Dive into the research topics of 'Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with Bindarit, an inhibitor of monocyte chemotactic proteins'. Together they form a unique fingerprint.
bindarit Medicine & Life Sciences
Monocyte Chemoattractant Proteins Medicine & Life Sciences
Ross River virus Medicine & Life Sciences
Alphavirus Medicine & Life Sciences
Myositis Medicine & Life Sciences
Arthritis Medicine & Life Sciences
Viruses Medicine & Life Sciences
Monocytes Medicine & Life Sciences
Rulli, N., Guglielmotti, A., Mangano, G., Rolph, M., Apicella, C., Zaid, A., Suhrbier, A., & Mahalingam, S. (2009). Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with Bindarit, an inhibitor of monocyte chemotactic proteins. Arthritis Rheumatism, 60(8), 2513-2523. https://doi.org/10.1002/art.24682
Rulli, Nestor ; Guglielmotti, Angelo ; Mangano, Giorgina ; Rolph, Michael ; Apicella, Claudia ; Zaid, Ali ; Suhrbier, Andreas ; Mahalingam, Suresh. / Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with Bindarit, an inhibitor of monocyte chemotactic proteins. In: Arthritis Rheumatism. 2009 ; Vol. 60, No. 8. pp. 2513-2523.
@article{884dfba541304fbc96b89cd7b85f3a97,
title = "Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with Bindarit, an inhibitor of monocyte chemotactic proteins",
abstract = "Alphaviruses such as chikungunya virus, Sindbis virus, o'nyong-nyong virus, Mayaro virus, and Ross River virus (RRV), are commonly associated with arthralgias and overt arthritides worldwide. Understanding the processes by which arthritogenic viruses cause disease is a prerequisite in the quest for better treatments. In this regard, we have recently established that monocyte/macrophages are mediators of alphavirus-induced arthritis in mice. We hypothesized that chemokines associated with monocyte/macrophage recruitment may play an important role in disease. The aim of the present investigations was to determine whether bindarit, an inhibitor of monocyte chemotactic protein (MCP) synthesis, could ameliorate alphavirus-induced rheumatic disease in mice.METHODS:Using our recently developed mouse model of RRV-induced arthritis, which has many characteristics of RRV disease (RRVD) in humans, the effects of bindarit treatment on RRVD in mice were determined via histologic analyses, immunohistochemistry, flow cytometry, real-time polymerase chain reaction analysis, enzyme-linked immunosorbent assay, and electrophoretic mobility shift assay.RESULTS:Bindarit-treated RRV-infected mice developed mild disease and had substantially reduced tissue destruction and inflammatory cell recruitment as compared with untreated RRV-infected mice. The virus load in the tissues was not affected by bindarit treatment. Bindarit exhibited its activity by down-regulating MCPs, which in turn led to inhibition of cell infiltration and lower production of NF-kappaB and tumor necrosis factor alpha, which are involved in mediating tissue damage.CONCLUSION:Our data support the use of inhibitors of MCP production in the treatment of arthritogenic alphavirus syndromes and suggest that bindarit may be useful in treating RRVD and other alphavirus-induced arthritides in humans",
author = "Nestor Rulli and Angelo Guglielmotti and Giorgina Mangano and Michael Rolph and Claudia Apicella and Ali Zaid and Andreas Suhrbier and Suresh Mahalingam",
doi = "10.1002/art.24682",
journal = "Arthritis Rheumatism",
Rulli, N, Guglielmotti, A, Mangano, G, Rolph, M, Apicella, C, Zaid, A, Suhrbier, A & Mahalingam, S 2009, 'Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with Bindarit, an inhibitor of monocyte chemotactic proteins', Arthritis Rheumatism, vol. 60, no. 8, pp. 2513-2523. https://doi.org/10.1002/art.24682
Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with Bindarit, an inhibitor of monocyte chemotactic proteins. / Rulli, Nestor; Guglielmotti, Angelo; Mangano, Giorgina; Rolph, Michael; Apicella, Claudia; Zaid, Ali; Suhrbier, Andreas; Mahalingam, Suresh.
In: Arthritis Rheumatism, Vol. 60, No. 8, 2009, p. 2513-2523.
T1 - Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with Bindarit, an inhibitor of monocyte chemotactic proteins
AU - Rulli, Nestor
AU - Guglielmotti, Angelo
AU - Mangano, Giorgina
AU - Rolph, Michael
AU - Apicella, Claudia
AU - Zaid, Ali
AU - Suhrbier, Andreas
AU - Mahalingam, Suresh
N2 - Alphaviruses such as chikungunya virus, Sindbis virus, o'nyong-nyong virus, Mayaro virus, and Ross River virus (RRV), are commonly associated with arthralgias and overt arthritides worldwide. Understanding the processes by which arthritogenic viruses cause disease is a prerequisite in the quest for better treatments. In this regard, we have recently established that monocyte/macrophages are mediators of alphavirus-induced arthritis in mice. We hypothesized that chemokines associated with monocyte/macrophage recruitment may play an important role in disease. The aim of the present investigations was to determine whether bindarit, an inhibitor of monocyte chemotactic protein (MCP) synthesis, could ameliorate alphavirus-induced rheumatic disease in mice.METHODS:Using our recently developed mouse model of RRV-induced arthritis, which has many characteristics of RRV disease (RRVD) in humans, the effects of bindarit treatment on RRVD in mice were determined via histologic analyses, immunohistochemistry, flow cytometry, real-time polymerase chain reaction analysis, enzyme-linked immunosorbent assay, and electrophoretic mobility shift assay.RESULTS:Bindarit-treated RRV-infected mice developed mild disease and had substantially reduced tissue destruction and inflammatory cell recruitment as compared with untreated RRV-infected mice. The virus load in the tissues was not affected by bindarit treatment. Bindarit exhibited its activity by down-regulating MCPs, which in turn led to inhibition of cell infiltration and lower production of NF-kappaB and tumor necrosis factor alpha, which are involved in mediating tissue damage.CONCLUSION:Our data support the use of inhibitors of MCP production in the treatment of arthritogenic alphavirus syndromes and suggest that bindarit may be useful in treating RRVD and other alphavirus-induced arthritides in humans
AB - Alphaviruses such as chikungunya virus, Sindbis virus, o'nyong-nyong virus, Mayaro virus, and Ross River virus (RRV), are commonly associated with arthralgias and overt arthritides worldwide. Understanding the processes by which arthritogenic viruses cause disease is a prerequisite in the quest for better treatments. In this regard, we have recently established that monocyte/macrophages are mediators of alphavirus-induced arthritis in mice. We hypothesized that chemokines associated with monocyte/macrophage recruitment may play an important role in disease. The aim of the present investigations was to determine whether bindarit, an inhibitor of monocyte chemotactic protein (MCP) synthesis, could ameliorate alphavirus-induced rheumatic disease in mice.METHODS:Using our recently developed mouse model of RRV-induced arthritis, which has many characteristics of RRV disease (RRVD) in humans, the effects of bindarit treatment on RRVD in mice were determined via histologic analyses, immunohistochemistry, flow cytometry, real-time polymerase chain reaction analysis, enzyme-linked immunosorbent assay, and electrophoretic mobility shift assay.RESULTS:Bindarit-treated RRV-infected mice developed mild disease and had substantially reduced tissue destruction and inflammatory cell recruitment as compared with untreated RRV-infected mice. The virus load in the tissues was not affected by bindarit treatment. Bindarit exhibited its activity by down-regulating MCPs, which in turn led to inhibition of cell infiltration and lower production of NF-kappaB and tumor necrosis factor alpha, which are involved in mediating tissue damage.CONCLUSION:Our data support the use of inhibitors of MCP production in the treatment of arthritogenic alphavirus syndromes and suggest that bindarit may be useful in treating RRVD and other alphavirus-induced arthritides in humans
U2 - 10.1002/art.24682
DO - 10.1002/art.24682
JO - Arthritis Rheumatism
JF - Arthritis Rheumatism
Rulli N, Guglielmotti A, Mangano G, Rolph M, Apicella C, Zaid A et al. Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with Bindarit, an inhibitor of monocyte chemotactic proteins. Arthritis Rheumatism. 2009;60(8):2513-2523. https://doi.org/10.1002/art.24682


text:
Just compensation C.R.O.S.S.R.O.A.D.S Jonathan De la Cruz 07/15/2011
Just compensation
P-Noy and his economic managers should thank San Miguel Corp. president and COO Ramon Ang for fast-tracking, as it were, the rehabilitation and upgrading of the Caticlan-Boracay International Airport in time for the second session of the 15th Congress. At least, with this $300 million long overdue undertaking they will have one Public-Private Partnership (PPP) project to bandy around as they prepare for the second round of roadshows meant to cajole investors to invest in the "big-ticket" projects, mainly infrastructure, works designed to catapult the country to the top tier members of Asean such as Malaysia, Thailand, Indonesia and, of course, Singapore whose basic infra networks and services, i.e., roads, bridges, airports, ports, telecoms and even power, are considered world-class and, yes, affordable.
It was not meant to be this way. After the "golden years of infrastructure works" as the Marcos years have come to be known, succeeding administrations wanted to sustain the momentum using the old ODA route. Alas, the Asian financial crisis set in and development funding for such big-ticket items almost dried up. So, the stage was set for the Build-Operate-Transfer (BOT) Law which was the original framework for various funding schemes such as this administration's PPP. The problem is the record as far as these BOT/PPP variations has been very spotty..... MORE
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