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Q: PHP: Hacer captura con html2canvas.js y guardarla en un servidor Veo que con esta librería podemos conseguir imprimir la imagen resultante en alguna parte del DOM o incluso descargarla.
Lo que necesito guardarla en un servidor con php mediante ajax. Del siguiente modo podría almacenar la img para pasarla luego por ajax.
var data = drawingCanvas.toDataURL('image/png');

¿Que debería hacer en dicho php para lograrlo?
Muchas gracias!

A: Javascript
var data = {
    image : drawingCanvas.toDataURL('image/png')
}

$.ajax({
    url: 'url del PHP',
    type: "POST",
    dataType: 'json',
    data: data,
    success: function(obj) {
        console.log(obj);
    },
    error: function(xhr, textStatus, errorThrown) {
        console.error(xhr);
    }
});

PHP
// crea la carpeta en caso de que no exista y le asigna permisos
function create_folder($path=false){
    if ($path && !file_exists($path))
        mkdir($path, 0777);
}

// convierte base64 enviado por ajax en archivo
function base64ToImage($folder , $data, $fileName = null){
    if(strlen($data)<3){
        return false;
    }

    list($type, $data) = explode(';', $data);
    list(, $data)      = explode(',', $data);
    $data = base64_decode($data);
    $folder = "{$_SERVER['DOCUMENT_ROOT']}/{$folder}/";

    create_folder($folder);

    if(!$fileName) $fileName = md5($data);
    $imgFile = "{$folder}/{$fileName}";

    if (file_exists($imgFile)) {
        unlink($imgFile);
    }

    if(!file_put_contents($imgFile, $data)){
        return false;
    }

    return $imgFile;
}

base64ToImage('documentos', $_POST['image'], 'imagen.png');


Sidney S. Bernstein is a licensed CPA located in Melrose Park, PA 19027. Sidney S. Bernstein has been issued a Pennsylvania license. All CPAs, including Sidney S. Bernstein, have at the minimum an undergraduate degree in accounting, passed a rigorous national exam and adhere to mandated continuing education requirements of their states in which they are licensed. CPAs can work in private industry, education or government but most people think of CPAs during tax season as the experts in tax preparation. Their overall training in business and knowledge in principles of general law and taxation provide CPAs with the skills to help individuals with both personal and business financial decisions.
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text:
My Account Blog
True West Magazine
Inside History
True Westerners
Heritage Travel
How many cavalry troops served during the Indian Wars?
March 18, 2013 Marshall Trimble
James Rowley
Laingsburg, Michigan
The Indian Wars boasted 10 cavalry regiments, with each regiment consisting of 12 companies (each the equivalent of an infantry company).
Most companies had between 60-70 men and officers (not counting cooks, medical personnel and musicians).
During that period, the 10 cavalry regiments totaled 10,970 men. In contrast, the 25 infantry regiments totaled 9,375 men.
How many people died during the Indian Wars? Paul Gortarez Phoenix, Arizona Considering the isolated…
I know that Gatling guns were used during the Civil War and Spanish-American War, but…
What clothing was issued to the cavalry troops in the Old West? James Rowley Laingsburg,…
Marshall Trimble is Arizona's official historian and the Wild West History Association's vice president. His latest book is 2018's Arizona Oddities: A Land of Anomalies and Tamales. Send your question, with your city/state of residence, to marshall.trimble@scottsdalecc.edu or Ask the Marshall, P.O. Box 8008, Cave Creek, AZ 85327.
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All Content © 2021 True West Magazine

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text:
Q: An example of a field extension which is not Galois. Let $K=\Bbb Z_p(U,V)$, the field of rational functions in two variables $U$ and $V$ over $\Bbb Z_p,$ be taken as the base field. Now consider the polynomial $f(X)=(X^p-U)(X^p-V) \in K[X].$ Then by Kronecker's theorem $\exists$ a field $L'$ such that $f(X)$ splits completely into linear factors in $L'[X].$ But that will imply $X^p-U$ and $X^p-V$ split completely into linear factors in $L'[X].$ Cosequently both these polynomials have a root in $L'.$ Let $u$ and $v$ be some zeros of $X^p-U$ and $X^p-V$ respectively. Then $u^p=U$ and $v^p=V.$ Now using the fact that $\text{Char}\ (L')=p$ we find that $$X^p-U=X^p-u^p=(X-u)^p.$$ So $u$ is the only zero of $X^p-U$ with multiplicity $p.$ Similarly we can show that $v$ is the only zero $X^p-V.$ Let $V_{L'} (f(X))$ the set of zeros of $f(X)$ in $L'.$ Then we have $$V_{L'} (f(X)) = \{u,v \}.$$
Let $L=K(u,v)$ be the smallest subfield of $L'$ containing $K,u$ and $v.$ Then we have $$V_L(f(X))=\{u,v \}.$$ Since both $U$ and $V$ are primes in $\Bbb Z_p(U,V)$ so both the polynomials $X^p-U$ and $X^p-V$ are irreducible in $K[X].$ So they cannot have any root inside $K.$ Therefore $u,v \notin K.$ Therefore the degree of extension $[L:K] > 1.$ Now let $G= \text {Gal}\ (L|K).$ Let $\sigma \in G.$ Since $X^p-U$ and $X^p-V$ are respectively the minimal polynomials of $u$ and $v$ over $K$ it follows that $\sigma (u) \in V_L(X^p-U) = \{u \}$ and $\sigma (v) \in V_L(X^p-V) = \{v \}.$ But this implies that $\sigma(u)=u$ and $\sigma(v)=v.$ Since $\sigma$ is completely determined by the pair $(\sigma(u),\sigma(v))=(u,v).$ It follows that $\sigma = \text{id}_L.$ This shows that $G$ is a trivial group i.e. $\#\ G=1 < [L:K].$ Hence $L$ is not a Galois extension of $K.$
Now my question is can we not show the non Galois extension just by taking $K=\Bbb Z_p(U), f(X)= X^p-U$ and $L=K(u)$? Then also I believe $L$ is not a Galois extension of $K.$ Right? But then what is necessity of adjoing two variables to $\Bbb Z_p$ to demonstrate an example of a non Galois extension as given in the lecture notes provided by our instructor?
Any help in this regard will be highly appreciated. Thank you very much.

redpajama_set_name: RedPajamaStackExchange


text:
You are here: Home / Uncategorized / Are the Olympics about to come to Pyongyang? North and South Korea propose 2032 bid
Are the Olympics about to come to Pyongyang? North and South Korea propose 2032 bid
Last week saw new hopes for peace emerge on the Korean peninsula as South Korean President Moon Jae-in visited Pyongyang to commence his 3rd summit with Kim Jong-un. The meeting saw a new series of declarations emerge, including commitments to eventually reopen the Kaesong Industrial Complex and the Mt. Kumgang Resort. However, most spectacular amongst the proposals was the aspiration to create a joint bid from both Koreas to host the Olympics in 2032. Such a measure would be unprecedented in history, but is it realistic or feasible?
For the Olympics to go ahead in Pyongyang, there would have to be massive changes. Political, economic and organisational ones to say the least. One wonders how it is possible for the country's limited infrastructure to accommodate millions of international visitors. The country would a completely new transport infrastructure, new roads, new railways and a vastly expanded number of international flight routes. It would need enhanced energy infrastructure, internet infrastructure and a completely new healthcare infrastructure to accommodate the visitors as well. To prepare the country for such a feat would cost billions, likely founded by the South Korean taxpayer if peace does get anywhere.
Then, there's the question of politics and tour guides. How can the current system where groups are accompanied by guides possibly be replicated on a scale to incorporate millions of visitors at once? The DPRK is only use to having about 1000 or so international visitors a day into the country (most whom are Chinese), high peak events such as the Pyongyang Marathon do not even come close to replicating the pull of let's say, the Olympics. North Korea will not appreciate having millions of rowdy westerners freely roaming the city, likely perceiving them to be disorderly, chaotic and getting into trouble. This aspect of organisation poses inevitably wider questions about the country's politics, such a bid under the status quo arrangement will inevitably attract high levels of international criticism and for the moralistic westerners, a sense of repulse.
Then of course, there's the question of the U.S, who refuse to lift any international sanctions until they achieve what they describe as the "final, fully verified denuclearisation of North Korea". Such sanctions relief would be needed in order to facilitate the changes needed to make such a competition possible. However, for all the peace overtures between the involved countries, denuclearisation remains a pipe dream with enormous obstacles setting the two sides apart. North Korea does not trust the United States, whom demand a unilateral capitulation in exchange for nothing. 14 years may be a long time for things to change, but a lot of that context may lever on the events of today.
All in all, a joint Olympics bid is a wonderful thing to aspire to, a symbol of peace, hope and unity on the Korean peninsula. However, there are many real challenges which stand in its way. North Korea itself must evolve in ways which can accommodate it, ways which will not be cheap or easy. Such a bid rests on the assumption the nuclear issue can be finally resolved for one and for all, as well as the necessity for North Korea to induce some sort of openness to its system that can win greater acceptance in the international community and not be boycotted by the west. So much to do, so little time! We truly hope for a peaceful, prosperous and better future between both Koreas together, but we have to be honest about the challenges ideas like this will unavoidably face. Here's hoping though!


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Begampur Saree
Begampur Saree%newline%Lightweight, translucent and woven using cotton yarn, Begampur sarees derive their name from the town in the Hooghly district of West Bengal where they are made. The tradition of weaving cotton sarees in the region can be traced as far back as the fourteenth century. They are traditionally characterised by broad borders, known as mathaapaars, that contrast with the saree's main body and its few motifs. The saree follows the cotton-weaving tradition of West Bengal, in combinations of white, black, red, orange, blue and purple, with the most common variant being laal paar, featuring a red border with the main body woven out of undyed, unbleached cotton. Common motifs on the saree include birds, animals and plants. Other variations may also have geometrical designs and borders with serrated patterns woven using extra weft threads, with various butas on the pallu. In 2010, the Weavers' Service Centre, Kolkata, led an initiative to revive Begampur sarees, focusing on design development and improving weaving and printing techniques, such as through the introduction of power looms. Today, the sarees feature stripes along with motifs of animals and plants on the borders and pallu — a change that has led to increased demand in the Indian market.
Chicago MAP Academy Encyclopedia of Art. "Begampur Saree". Accessed January 28, 2023. https://mapacademy.io/article/begampur-saree/
MLA "Begampur Saree." MAP Academy Encyclopedia of Art. https://mapacademy.io/article/begampur-saree/. Accessed 28, January, 2023.
Harvard MAP Academy Encyclopedia of Art. (2022) Begampur Saree. [Online]. Available at: https://mapacademy.io/article/begampur-saree/. (Accessed: 28, January, 2023)
Lightweight, translucent and woven using cotton yarn, Begampur sarees derive their name from the town in the Hooghly district of West Bengal where they are made. The tradition of weaving cotton sarees in the region can be traced as far back as the fourteenth century. They are traditionally characterised by broad borders, known as mathaapaars, that contrast with the saree's main body and its few motifs.
The saree follows the cotton-weaving tradition of West Bengal, in combinations of white, black, red, orange, blue and purple, with the most common variant being laal paar, featuring a red border with the main body woven out of undyed, unbleached cotton. Common motifs on the saree include birds, animals and plants. Other variations may also have geometrical designs and borders with serrated patterns woven using extra weft threads, with various butas on the pallu.
In 2010, the Weavers' Service Centre, Kolkata, led an initiative to revive Begampur sarees, focusing on design development and improving weaving and printing techniques, such as through the introduction of power looms. Today, the sarees feature stripes along with motifs of animals and plants on the borders and pallu — a change that has led to increased demand in the Indian market.
Blindboys
Blindboys is a community-driven online platform exploring and showcasing photography and new visual perspectives from…
Minal Vazirani
President of the auction-house Saffronart, as well as an arts administrator and patron, Minal Vazirani…
Sir JJ School of Art, Mumbai
Established in 1865, Sir JJ School of Art is one of the oldest and most…
Mardaani Khel
Originating in the Indian Deccan region, mardaani khel was a popular armed martial art form…
Banerjee, Abhradip. 2016. "Understanding Some of the Key Factors Responsible for Transition within an Indian Cotton Weaving Tradition." Asian Journal of Social Science 44 (4/5): 571–99. https://www.jstor.org/stable/43954182.
"Begumpuri, West Bengal." 2018. Bunavat. https://bunavat.com/blogs/blogs/begumpuri-west-bengal.
Chishti, Rta Kapur. 2013. Saris: Tradition and Beyond. New Delhi: Roli Books.
Mohan, Sreemathy. 2016. "A Bengal Handloom Trail." The Hindu. https://www.thehindu.com/features/metroplus/on-a-bengal-handloom-trail/article8537134.ece.


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Q: How to get ID of changed file on Google Drive Im integrating google drive API push notification on my website.
Current work:

*

*Register web app on dev console, domain etc...

*OAuth authorization

*Create channel if does not exist

*Setup servlet that waits google drive POST request if change happened

*Change happens on google drive (upload or delete)

*Servlet catch POST request from google drive when change happens

*Cached message: { "kind": "drive#change", "id": "8664", "selfLink": "https://www.googleapis.com/drive/v2/changes/8664"}
Google drive API representation of a change to a file:
{
"kind": "drive#change",
  "id": long,
  "fileId": string,
  "selfLink": string,
  "deleted": boolean,
  "modificationDate": datetime,
  "file": files Resource
}

How to get fileId? Why Google Drive does not send me missing fields?? What am I doing wrong?
Watch change code:
service -> created ok
channelId -> UUID
channelType -> web_hook
channelAddress -> https://example.com/GoogleDriveWebhook (GoogleDriveWebhook is servlet)
public static Channel watchChange(Drive service, String channelId, String channelType, String channelAddress) {
        Channel channel = new Channel();
        channel.setId(channelId);
        channel.setType(channelType);
        channel.setAddress(channelAddress);
        channel.setExpiration(new Date().getTime() + (600000 * 2));//20 min session for channel (test environment)
        try {
            return service.changes().watch(channel).execute();
        } catch (IOException e) {
            System.out.println("Something is wrong with instancing new channel");
            e.printStackTrace();
        }
        return null;
    }

...so obviously app catch change that google drive sends, I am stuck plz help!

A: The POST message sent when a notifications occurs will have the File ID in the headers (see "X-Goog-Resource-ID" below). If you're watching a File or Folder you won't even have a body to parse.
Change notification message for Files resources, which does not include a request body:
POST https://example.com/notifications // Your receiving URL.
Content-Type: application/json; utf-8
Content-Length: 0
X-Goog-Channel-ID: 4ba78bf0-6a47-11e2-bcfd-0800200c9a66
X-Goog-Channel-Token: 398348u3tu83ut8uu38
X-Goog-Channel-Expiration: Tue, 19 Nov 2013 01:13:52 GMT
X-Goog-Resource-ID:  ret08u3rv24htgh289g
X-Goog-Resource-URI: https://www.googleapis.com/drive/v2/files/ret08u3rv24htgh289g
X-Goog-Resource-State:  update
X-Goog-Changed: content,properties
X-Goog-Message-Number: 10

Change notification message for Changes resources, which includes a request body:
POST https://example.com/notifications // Your receiving URL.
Content-Type: application/json; utf-8
Content-Length: 118
X-Goog-Channel-ID: 8bd90be9-3a58-3122-ab43-9823188a5b43
X-Goog-Channel-Token: 245t1234tt83trrt333
X-Goog-Channel-Expiration: Tue, 19 Nov 2013 01:13:52 GMT
X-Goog-Resource-ID:  ret987df98743md8g
X-Goog-Resource-URI: https://www.googleapis.com/drive/v2/changes
X-Goog-Resource-State:  changed
X-Goog-Message-Number: 23

{
  "kind": "drive#changes",
  "id": "12345",
  "selfLink": "https://www.googleapis.com/drive/v2/changes/12345"
}

For more details see https://developers.google.com/drive/web/push#msg-format


text:
Тит Иосифович Заячковский (, , Лопянка, ныне в Долинской общине, Ивано-Франковская область Украины — , Дора, ныне часть , Ивано-Франковская область Украины) — украинский общественный и политический деятель, львовский судья, с 1895 по 1901 годы посол в Галицком краевом сейме.

Биография
Окончил юридический факультет Львовского университета. Работал в судах городов Будзанов, Тысменица, Коломыя, Галич, во Львове работал в Высшем краевом суде и на таможне. Почётный гражданин городов Будзанов и Тысменица. После выхода на пенсию открыл адвокатскую канцелярию в Яблонове. Похоронен на Лычаковском кладбище во Львове.

Его отцом был греко-католический священник Иосиф Заячковский. Дети: Роман, комиссар Коломыи от имени ЗУНР в годы Гражданской войны; Мирон, руководитель Компартии Западной Украины.

Примечания

Литература

 Чорновол І. 199 депутатів Галицького сейму. — Львів: Тріада плюс, 2010. — С. 134

Юристы Украины
Юристы Польши
Политики Украины
Выпускники Львовского университета
Похороненные на Лычаковском кладбище

redpajama_set_name: RedPajamaWikipedia


text:
Current Opinion in Endocrinology, Diabetes and Obesity
The Endocrinologist (1991 - 2010)
Home > January/February 2003 - Volume 13 - Issue 1 > Cyclical Cushing Syndrome Caused by Intermittent Ectopic ACT...
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Cyclical Cushing Syndrome Caused by Intermittent Ectopic ACTH Homogenesis Responsive to Somatostatin Analogues
Kaltsas, Th. MD*; Krassas, G. E. MD*; Pontikides, N. MD*; Tsotsia, E. MD*; Tsagarakis, S. MD, PHD†
The Endocrinologist: January/February 2003 - Volume 13 - Issue 1 - pp 7-11
Cushing disease accounts for 80% to 85% of ACTH-dependent disease, whereas 15% to 20% is caused by ectopic sources. Cyclical Cushing syndrome is an unusual phenomenon and is frequently associated with a pituitary adenoma. Diagnostic and therapeutic problems arise when diagnostic tests are performed in the "quiescent phase" of the disease at a time when cortisol levels are normal, when the tests confirm a cyclic ectopic hypercortisolemic pattern but no tumor can be identified, or when radiologic evaluation reveals a coincidental pituitary abnormality.
We present the case of a 29-year-old female with clinical Cushing syndrome caused by periodic hormonogenesis from an ectopic ACTH-secreting tumor, which was proved to be a bronchial carcinoid that responded to long acting somatostatin analogue (SM-a) treatment (Sandostatin LAR). The patient also had a coexisting pituitary microadenoma.
Recently, the SM-a octreotide has been shown to be effective in reducing cortisol levels in several communications. Our case confirms previous data concerning the usefulness of this therapeutic regime in reducing cortisol and ACTH levels in patients with ectopic ACTH hormonogenesis. Moreover, to our knowledge this is the first report that shows such a beneficial effect using the new long acting SM-a (Sandostatin LAR).
*From the Department of Endocrinology and Metabolism, Panagia Hospital, Thessaloniki, Greece.
†From the Department of Endocrinology and Metabolism, Evagelismos Hospital, Athens, Greece.
Address correspondence and reprint requests to: G. Krassas, M.D., Associate Professor of Medicine, Department of Endocrinology and Metabolism, Panagia Hospital, N. Plastira 22, N. Krini 55132, Thessaloniki, Greece. Telephone: +30 2310 447444; Fax: +30 2310 447444; E-mail: krassas@the.forthnet.gr
The diagnosis of Cushing syndrome remains one of the most difficult challenges in clinical endocrinology. The source of steroid excess is classified as either corticotropin (ACTH)-dependent (80%) or ACTH-independent (adrenal autonomy) 20% [1]. Cushing disease accounts for 80% to 85% of ACTH-dependent disease, whereas 15% to 20% of cases are caused by ectopic sources [2,3]. The tumors that produce the ectopic corticotropin syndrome are primarily of neuroendocrine cell origin. Small cell lung cancer is the most common cause of ectopic ACTH production, but usually in these patients the advanced and widespread malignancy dominates the clinical picture and the length of survival is short. Such patients rarely develop the classical, clinically recognizable Cushing syndrome, and usually seek treatment for a rapid wasting disease, hyperpigmentation, hypokalemia, myopathy, and diabetes mellitus. On the contrary, bronchial carcinoid is the most common cause of ectopic ACTH syndrome, presenting with clinical features of classical Cushing syndrome [4].
Cyclical Cushing syndrome is an unusual manifestation first observed in a patient with ectopic ACTH production from a bronchial adenoma and the term "periodic or intermittent hormonogenesis" has also been used to describe this phenomenon [5]. It is most frequently associated with a pituitary adenoma [6]. Periodic hormonogenesis adds difficulty in the diagnostic workup of Cushing syndrome because the different tests used may be intermittently normal depending on the time at which they are performed. Moreover, further diagnostic and therapeutic problems arise, when biochemical tests confirm cyclical ectopic hypercortisolemic pattern, but no tumor can be found or pituitary radiologic evaluation reveals a coincidental adenoma-like lesion, a finding that is present in up to 10% of normal adults [7].
Recently, the somatostatin analogue (SM-a) octreotide has been shown to be effective in reducing cortisol levels in several publications [8–10]. We report a patient with cyclical Cushing syndrome caused by periodic hormonogenesis from an ectopic ACTH-secreting tumor, which was proved to be a bronchial carcinoid responsive to the new long acting SM-a (Sandostatin LAR) treatment. The patient also had a coincidental pituitary microadenoma.
Back to Top | Article Outline
A 29-year-old female patient presented in May 2001 at the department of Endocrinology, Panagia Hospital with weakness, muscle wasting, easy bruising, central obesity, increased weight by 6 kg in the last couple of months, moon face, striae, acne, deterioration of preexisting slight hirsutism, menstrual abnormalities, alopecia, polyuria, and hyperpigmentation although she has not been exposed to the sun. On clinical examination she had the typical features of Cushing syndrome and was found to be hypertensive (180– 100 mmHg). The initial laboratory findings (Table 1) showed that the patient had ACTH-dependent Cushing syndrome. Abdominal computed tomography (CT) showed bilateral hyperplasia of the adrenals, whereas sellar magnetic resonance imaging (MRI) revealed a 2-mm diameter tumor of in the right side of the pituitary gland.
Because of the low serum potassium levels and failure of cortisol response to high-dose dexamethasone suppression, an ectopic source of ACTH secretion was suspected and a readmission for further investigation was arranged. During her readmission (June, 2001) her cushingoid features were noted to have improved. She was amenorrheic but there was improvement in acne, moon face and weakness. She had lost 4 kg of weight and she was normo- to hypotensive, so her antihypertensive therapy was discontinued. The endocrine-biochemical investigations during her second admission (Table 2) revealed that the patient was normokalaemic without hypercortisolemia or hyperandrogenemia. Chest CT revealed two nodules, approximately 1.8 cm each, in the upper part of the lower lobe of the left lung. Bronchoscopy did not reveal abnormalities. The patient was discharged at her request for family reasons.
She returned 35 days later and reported that she had been in good health up to the previous week when her symptoms recurred. On examination she was hypertensive, with new striae, loss of hair, weakness, and increase in body weight (6 kg). Repeat laboratory investigations (Table 3) showed that the patient was again hypokalaemic and hypercortisolemic. A CRH test was performed with 100 μg CRH IV (Table 4), followed by inferior petrosal venous sinus sampling before and after combined CRH (100 μg CRH IV) and vasopressin (10 μg DDAVP IV) stimulation. The results of these tests (Table 5) confirmed the diagnosis of an ectopic ACTH-dependent Cushing syndrome with periodic hormonogenesis. Immediately after the final investigation and while she was waiting for thoracic surgery, the patient began treatment with the long acting somatostatin analogue (Sandostatin LAR, Novartis Pharma AG, Basle, Switzerland) 30 mg IM once every month. Serum ACTH, cortisol, and free urinary cortisol levels were measured every week for 4 consecutive weeks. A decrease in both serum and urine cortisol levels was found compared with baseline, which normalized at the end of the fourth week (Table 6). The patient had also a significant improvement in her clinical symptomatology. Because of these favorable results, her LAR treatment was continued and blood was taken every 2 weeks for ACTH and cortisol measurements. These results are presented in Table 6. Plasma ACTH levels also decreased to approximately 60% of baseline by the end of the fourth week, and remained so for the rest of the examination period (Table 6).
The patient underwent surgery in November 2001 and a tumor measuring 3.4 cm in diameter was removed from the lower lobe of the left lung. Pathologic examination showed that the tumor was a carcinoid that immunocytochemically was positive to ACTH, chromogranin, and specific neuronal enolase. Metastasis of the tumor was found in two excised lymph nodes.
Postsurgically the patient had a significant improvement. She became normokalaemic and normotensive, with resolution of her clinical symptoms. One, 2, and 3 months after the operation her cortisol and ACTH levels were within normal range.
All endocrine tests were carried out between 0800 and 1100. The high-dose dexamethasone-suppression test was performed by administering an oral dose of 2 mg every 6 hours during a 2-day period. Blood was withdrawn for cortisol measurements at 0900. For CRH stimulation 100 μg human CRH (Ferring Arzneimittel GmbH, Kiel, Germany) was injected IV. Blood was withdrawn through an indwelling cannula before (−15) and 0, 15, 30, 45, 60, 90, and 120 minutes after the initiation of test. Inferior petrosal sinus sampling was carried out in the neuro-angiography suite. Under local anesthesia, the femoral vein was cannulated. Two "multipurpose" catheters (Cordis Corporation, Miami, FL) with guide wire were advanced into the right and left inferior petrosal sinuses, guided by digital subtraction imaging with the injection of small quantities of non-ionic water soluble contrast (Lopamidol). Human CRH (100 μg) and 10 μg DDAVP/Desmopressin Acetate (Ferring AB, Malmo, Sweden) were injected intravenously after both inferior petrosal sinus sampling catheters were in place. Samples were taken simultaneously from both inferior petrosal sinuses and a peripheral vein before (0) and at 5, 10, 15, 60, 90, and 120 minutes after the bolus injection. In patients with a pituitary source of excess ACTH production, the petrosal/peripheral gradient of ACTH (without or with CRH stimulation) is greater than 2 or 3, respectively, whereas localization to either side of pituitary can be predicted with 55% to 80% accuracy if the gradient across the two sides is greater than 1.4 [11–13].
Samples for ACTH were collected in EDTA tubes on ice, and plasma separated by centrifugation within 30 min and stored at −20°C until assayed. Plasma ACTH was determined by a commercially available two-site highly sensitive immunoradiometric assay (Nichols, Bad Nauheim, Germany). Urinary-free cortisol excretion was determined by RIA (NEN, Dreilich, Germany) and serum cortisol was measured by commercially available immunoradiometric assay (Diachel, Webster, TX).
The diagnosis and differential diagnosis of Cushing syndrome is one of the most perplexing problems in endocrinology and still remains a challenge for endocrinologists. Cushing syndrome caused by ectopic ACTH production was first described in 1928 by Brown [14] and is recognized to occur in association with small cell carcinoma of the bronchus and carcinoid tumors of the bronchus, pancreas, and thymus, but is most commonly caused by bronchial carcinoid [4]. Some carcinoid tumors with associated Cushing syndrome produce corticotrophin-releasing factor instead of, or as well as, ACTH.
In our case, which had clear clinical features of Cushing syndrome, the urine-free cortisol value of 1122.6 (μmol/molCr/24h) was considered diagnostic [15]. Our suspicion that we were dealing with an ectopic ACTHdependent Cushing syndrome, despite the presence of a pituitary tumor on MRI, was based on the low potassium, high ACTH levels and failure of serum cortisol and urine-free cortisol to suppress after the high-dose dexamethasone suppression test. We considered the abnormality on pituitary imaging as a coincidence, as it is known that approximately 10% of the normal adult population has pituitary abnormalities on MRI that are compatible with pituitary microadenoma known as "pituitary incidentaloma" [16,17]. The finding of two nodules in the upper part of the lower lobe of the left lung on chest CT further supported the diagnosis of ectopic Cushing syndrome.
To differentiate pituitary adenomas from the ectopic ACTH syndrome it is necessary to use stimulation tests. The most powerful test for determining the origin (pituitary vs. ectopic) and lateralization (left vs. right hemipituitary) of an ACTH-secreting lesion is inferior petrosal sinus sampling with simultaneous administration of ovine CRH [11,18]. The results of all these tests, which were performed in our patient, confirmed the diagnosis of an ectopic ACTH-dependent Cushing syndrome.
Although the typical clinical course of Cushing syndrome is one of continuous progression, cases in which cortisol production fluctuates have been reported. In particular, so-called cyclical Cushing syndrome has been described, which is characterized by peaks of cortisol production interspersed with normal levels [5,19–22]. Cyclical Cushing syndrome is an unusual phenomenon first observed in a patient with ectopic ACTH production from a bronchial adenoma and later being described in patients with pituitary or adrenal tumors [6]. Affected subjects have temporary biochemical and clinical remission of hypercortisolism caused by periodic hormonogenesis by the tumor, as illustrated also by our case. In an extensive study, Atkinson et al. [21] found that cycles of excess cortisol secretion varying in duration between 12 hours and 85 days. The criteria that they suggested for diagnosis of cyclicity consisted of three peaks and two troughs of cortisol production with similar intervals between the peaks. These criteria existed in our patient, who had approximately 45-day intervals between the peaks.
The etiology of periodic hormonogenesis in ectopic Cushing syndrome is not fully understood. Three hypotheses have been proposed. The first is that the increase in hormone production follows the tumoral growth and development of new ACTH-secreting cells, whereas the decreased hormonal production is caused by areas of patchy necrosis in the ACTH-secreting tumor [5,23], which could account for intermittent ACTH secretion and thus variable degrees of adrenal stimulation. A second possibility as yet uncharacterized inhibitors or stimulators of ACTH release, elaborated within the tumor or other tissue, and finally, that the tumor is responsive but insensitive to feedback control [5]. So a sluggish delayed response would result in cyclicity.
Surgical removal of the tumor is the treatment of choice. Recently it has been shown that SM-a are effective in reducing cortisol levels in such patients and could be used preoperatively or in cases where surgical intervention is impossible because of lack of localization of the tumor [8–10]. Our case confirms previous data concerning the usefulness of this therapeutic regime in reducing cortisol and ACTH levels in patients with ectopic ACTH hormonogenesis. Moreover, to our knowledge, this is the first report, which shows such a beneficial effect using the new long acting somatostatin analogue Sandostatin LARR, which is most probably superior to other forms of SM-a treatment because of the convenience of administration (once every month) and favorable tolerability by patients. Unfortunately, OctreoScan was not performed for technical reasons. One can argue that the reduced levels of ACTH and cortisol were caused by another trough of cyclicity and not to the medication. However, the fact that the cortisol levels became normal immediately after the first injection and remained so for the whole period of treatment is in favor of the latter. In our patient, SM-a induced only a partial ACTH drop; this decrease however, was sufficient to normalize cortisol secretion. The partial effect of octreotide suggests either a defective transduction system on the tumor cells or a heterogeneous population of responsive and non-responsive tumor cells. However, a different type of Sm receptor being expressed by the tumor cannot be excluded.
There are several key points illustrated by this case report. Periodic hormonogenesis can render the diagnosis of Cushing syndrome (particularly because of ectopic ACTH production) difficult, because the results of the stimulatory and suppressive tests depend on the time at which they are performed. Hypokalemia and high ACTH levels, which do not suppress after high-dose dexamethasone suppression, should alert the clinician to the diagnosis of ectopic ACTH syndrome even in the presence of a pituitary adenoma like lesion. Finally, although the surgical removal of the ectopic source of ACTH is the treatment of choice, long acting somatostatin analogue treatment before surgery, in order to make the patient eucortisolemic, in cases were localization of the tumor is not possible, or when the patient is too frail to undergo surgery, should be considered.
1. Trainer PJ, Grossman A: The diagnosis and differential diagnosis of Cushing syndrome. Clin Endocrinol (Oxf) 1991; 34: 317–30.
Cited Here... |
PubMed | CrossRef
2. Orth DN: Cushing syndrome. N Engl J Med 1995; 332: 791–803.
Cited Here...
3. Wajchenberg BL, Mendonca BB, Liberman B, et al.: Ectopic adrenocorticotropic hormone syndrome. Endocr Rev 1994; 15: 752–87.
4. Meier CA, Biller BMK: Clinical and biochemical evaluation of Cushing syndrome. Endocrinol Metab Clin North Am 1997; 26: 741–62.
5. Bailey RE. Periodic hormonogenesis – A new phenomenon. Periodicity in function of a hormone-producing tumor in man. J Clin Endocrinol 1971; 32: 317–27.
6. Sakiyama R, Ashcraft WW, Van Herle AJ: Cyclic Cushing syndrome. Am J Med 1984; 77: 944–6.
7. Aron DC, Howlett TA: Pituitary incidentalomas. Endocrinol Metab Clin North Am 2000; 29: 205–21.
8. Phlipponneau M, Nocaudie M, Epelbaum J, et al.: Somatostatin analogs for the localization and preoperative treatment of an adrenocorticotropin-secreting bronchial carcinoid tumor. J Clin Endocrinol Metab 1994; 78: 20–4.
9. Van den Bruel A, Bex M, Van Dorpe J, et al.: Occult ectopic ACTH secretion due to recurrent lung carcinoid: long-term control of hypercortisolism by continuous subcutaneous infusion of octreotide. Clin Endocrinol (Oxf) 1998; 49: 541–6.
View Full Text | PubMed | CrossRef
10. Peri A, Bemporad D, Parenti G, et al.: Cushing syndrome due to intermittent ectopic ACTH production showing a temporary remission during a pulmonary infection. Eur J Endocrinol 2001; 145: 605–11.
11. Oldfield EH, Doppman JL, Nieman LK, et al.: Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing syndrome. N Engl J Med 1991; 325: 897–905.
12. de Herder WW, Uitterlinden P, Pieterman H, et al.: Pituitary tumour localization in patients with Cushing disease by magnetic resonance imaging: Is there a place for petrosal sinus sampling? Clin Endocrinol (Oxf) 1994; 40: 87–92.
13. Findling JW, Doppman JL: Biochemical and radiologic diagnosis of Cushing syndrome. Endocrinol Metab Clin North Am 1994; 23: 511–37.
14. Brown WH: A case of pluriglandular syndrome (diabetes of bearded woman). Lancet 1928; ii: 1022–3.
15. Tsigos C, Chroussos GP: Differential diagnosis and management of Cushing syndrome. Ann Rev Med 1996; 47: 443–61.
16. Molitch ME, Russell EJ: The pituitary "incidentaloma". Ann Intern Med 1990; 112: 925–31.
17. Hall WA, Luciano MG, Doppman JL, et al.: Pituitary magnetic resonance imaging in normal human volunteers: occult adenomas in the general population. Ann Intern Med 1994; 120: 817–20.
18. Findling JW, Kehoe ME, Shaker JL, et al.: Routine inferior petrosal sinus sampling in the differential diagnosis of adrenocorticotropin (ACTH)-dependent Cushing syndrome: Early recognition of the occult ectopic ACTH syndrome. J Clin Endocrinol Metab 1991; 73: 408–13.
19. Brown RD, Van Loon GR, Orth DN, et al.: Cushing disease with periodic hormonogenesis: one explanation for paradoxical response to dexamethasone. J Clin Endocrinol Metab 1973; 36: 445–51.
20. Sakiyama R, Ashcraft MW, Van Herle AJ: Cyclic Cushing syndrome. Am J Med 1984; 77: 944–6.
21. Atkinson AB, Kennedy AL, Carson DJ, et al.: Five cases of cyclical Cushing syndrome. Br Med J 1985; 291: 1453–7.
22. Vagnucci AH, Evans E: Cushing disease with intermittent hypercortisolism. Am J Med 1986; 80: 83–8.
23. Thorner MO, Martin WH, Ragan GE, et al.: A case of ectopic ACTH syndrome: diagnostic difficulties caused by intermittent hormone secretion. Acta Endocrinol 1982; 99: 364–70.
The Endocrinologist13(1):7-11, January/February 2003.
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Absolutely everyone has it in them to develop themselves and reach their full potential. We all have the ability to do a little more each day than we think we can possibly do. This could be in work, relationships, family, sports, fitness or pretty much any situation that requires you to focus your mind-set and behaviours.
It would be amazing if you could click your fingers and release your full potential in seconds but the reality is that if you want to unlock the door to your personal excellence, this takes some consideration and steps towards self-development.
Developing the right mind-set and the motivation to take action to develop yourself is the key.
• What would be the impact of things staying the same for you?
• What would your life look like if you committed to your own self development and changed your current situation?
Which one of the answers looks more appealing and more likely to result in a positive impact for your life?
Any habits you have, or put another way - any reoccurring thoughts or behaviours you have that could be holding you back need to be eliminated from your life if you are serious about unleashing your full potential.
Becoming more aware of any negative habits you have will be the first step in being able to eliminate the thoughts and behaviours that are preventing you from achieving optimum success.
The next time you hear yourself think "I couldn't possibly do that", "I'm no good at that" or you find yourself taking the decision to avoid trying something in a different way – think about what this habit is really doing for you.
Imagine what could happen if little by little you managed to change your negative thoughts into positive ones and step by step managed to edge out of your comfort zone so new opportunities could crop up?
According to the quote by Lou Holtz, "If you're bored with life, if you don't get up every morning with a burning desire to do things, you don't have enough goals".
The majority of us have all been there at some stage in our lives, felt a bit lost with no clear direction or goals to keep us motivated.
There is a direct link between happiness and the attainment of goal which is why we feel so much satisfaction when we achieve our goals. Goal setting is the one activity that sets apart those who just get by in life and those who are successful, self-starter types, full of potential.
Write your goals down, break your goals down into manageable chunks and measure your progress!


text:
Lijst van gemeentelijke monumenten in Velp (Gelderland)
Lijst van gemeentelijke monumenten in Velp (Noord-Brabant)


MOCA PDC will be closed on Saturday, June 9 and Sunday, June 10 due to the 2018 LA Pride Festival activities.
Décor: Barbara Bloom, Andrea Fraser, Louise Lawler presents works by Barbara Bloom, Andrea Fraser, and Louise Lawler that play with various methods of the presentation and display of art. The exhibition is centered around Bloom's rarely seen The Reign of Narcissism (1988-89), a full-scale faux-neoclassical period room dedicated to a fictionalized version of the artist. Replete with crown moldings, gilded chairs, vanity mirrors, and plaster busts of the artist, the installation revels in the slippage between interior decorating and museum display. Videos and photographs by Lawler and Fraser focus on images of art in museums and the typically overlooked architectural details of institutions, with both artists invested in exploring the myriad ways décor—the arrangement of objects in space—carries meaning.
Exhibitions at MOCA are supported by the MOCA Fund for Exhibitions with lead annual support provided by Sydney Holland, founder of the Sydney D. Holland Foundation. Generous funding is also provided by Judith and Alexander Angerman, Delta Air Lines, Earl and Shirley Greif Foundation, and Nathalie Marciano and Julie Miyoshi.


Front dual rate coil springs for 55-57 Chevy Car, Small Block. Sold as pair.
StreetGRIP front coil springs improve the handling, ride quality and stance of your 1955-1957 tri-five Chevy including Bel Air, 150 and 210 models. They feature a dual rate design which gives your classic the best of both worlds. The "soft" spring section helps your car to comfortably transition over small road irregularities. As your car's springs further compress -- such as when encountering large bumps and cornering loads -- the design transition to the firmer spring rate. StreetGRIP coil springs are CNC cold-wound from high tensile premium steel by then powder-coated for long-lasting, consistent operation. RideTech works closely with Hyperco, our technology partner, to develop B-body-specific springs for exceptional performance and comfort.


text:
<?php
namespace SIGESRHI\AdminBundle\Entity;

use Doctrine\ORM\Mapping as ORM;
use Symfony\Component\Validator\Constraints as Assert;

/**
 * Conocimientoplaza
 *
 * @ORM\Table(name="conocimientoplaza")
 * @ORM\Entity
 */
class Conocimientoplaza
{
    /**
     * @var integer
     *
     * @ORM\Column(name="id", type="integer", nullable=false)
     * @ORM\Id
     * @ORM\GeneratedValue(strategy="IDENTITY")
     * @ORM\SequenceGenerator(sequenceName="conocimientoplaza_id_seq", allocationSize=1, initialValue=1)
     */
    private $id;

    /**
     * @var \Conocimiento
     *
     * @ORM\ManyToOne(targetEntity="Conocimiento", inversedBy="idconocimientoplaza")
     * @ORM\JoinColumns({
     *   @ORM\JoinColumn(name="idconocimiento", referencedColumnName="id")
     * })
     */
    private $idconocimiento;

    /**
     * @var \Plaza
     *
     * @ORM\ManyToOne(targetEntity="Plaza", inversedBy="idconocimientoplaza")
     * @ORM\JoinColumns({
     *   @ORM\JoinColumn(name="idplaza", referencedColumnName="id")
     * })
     */
    private $idplaza;

    /**
     * @var string
     *
     * @ORM\Column(name="tipoconocimiento", type="string", length=1, nullable=false)
     * @Assert\NotNull(message="Debe ingresar el tipo del conocimiento")
     */
    private $tipoconocimiento;

    public function __toString(){
        if($this->getTipoconocimiento() == 'I')
           return $this->getIdconocimiento()->getNombreconocimiento()." (Indispensable) ";
        else
           return $this->getIdconocimiento()->getNombreconocimiento()." (Deseable) ";
    }

    /**
     * Get id
     *
     * @return integer
     */
    public function getId()
    {
        return $this->id;
    }

    /**
     * Set tipoconocimiento
     *
     * @param string $tipoconocimiento
     * @return Conocimientoplaza
     */
    public function setTipoconocimiento($tipoconocimiento)
    {
        $this->tipoconocimiento = $tipoconocimiento;

        return $this;
    }

    /**
     * Get tipoconocimiento
     *
     * @return string
     */
    public function getTipoconocimiento()
    {
        return $this->tipoconocimiento;
    }

    /**
     * Set idconocimiento
     *
     * @param \SIGESRHI\AdminBundle\Entity\Conocimiento $idconocimiento
     * @return Conocimientoplaza
     */
    public function setIdconocimiento(\SIGESRHI\AdminBundle\Entity\Conocimiento $idconocimiento = null)
    {
        $this->idconocimiento = $idconocimiento;

        return $this;
    }

    /**
     * Get idconocimiento
     *
     * @return \SIGESRHI\AdminBundle\Entity\Conocimiento
     */
    public function getIdconocimiento()
    {
        return $this->idconocimiento;
    }

    /**
     * Set idplaza
     *
     * @param \SIGESRHI\AdminBundle\Entity\Plaza $idplaza
     * @return Conocimientoplaza
     */
    public function setIdplaza(\SIGESRHI\AdminBundle\Entity\Plaza $idplaza = null)
    {
        $this->idplaza = $idplaza;

        return $this;
    }

    /**
     * Get idplaza
     *
     * @return \SIGESRHI\AdminBundle\Entity\Plaza
     */
    public function getIdplaza()
    {
        return $this->idplaza;
    }
}

redpajama_set_name: RedPajamaGithub


text:
Q: Snapping Header: Which controls to use inside ObjectPageHeaderContent I am verifying the guidelines for Snapping Header.
I would like to know which controls are used as children of ObjectPageHeaderContent to prepare forms with label-text pairs. Actually I'm using a VerticalLayout with ObjectStatus controls and another VerticalLayout with a Title and NumericContent to prepare the item like 3rd item in the ObjectPageHeaderContent.
However the result does not look like the example. The guidelines explain FormFacet and KeyValueFacet, but did not understand that. How can I achieve the same result as in the given example.
Thank you in advance.

A: Please have a look at ObjectPageHeaderContent
In this example I used the original coding from sap.uxap.sample.HeaderContent
I also used Vertical Layout and added Title, to make it look like the mentioned design element "plain text facet".
It also renders in multiple lines.
In this case, "plain text facet" is just a term used by design, to describe this element.
The implementation of this design element is accomplished using different UI5 controls.
            <ObjectPageHeaderContent>
                           <content>
                                           <layout:VerticalLayout>
                                                           <m:ObjectStatus title="User ID" text="12345678"/>
                                                           <m:ObjectStatus title="Functional Area" text="Developement"/>
                                                           <m:ObjectStatus title="Cost Center" text="PI DFA GD Programs and Product"/>
                                                           <m:ObjectStatus title="Email" text="email@address.com"/>
                                           </layout:VerticalLayout>

                                           <layout:VerticalLayout>
                                           <m:Title text="YourHeader" titleStyle="H4"/>
                                           <m:Text width="200px"
                                                                          text="Hi, I'm Denise. I am passionate about what I do and I'll go the extra mile to make the customer win."/>
                                                           <m:ObjectStatus title="Email" text="email@address.com"/>
                                           </layout:VerticalLayout>

                                           <m:ObjectStatus text="In Stock" state="Error"/>

Please describe the other small changes, so that we can look at them.


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This chic cheery chick leads the team in fun and fashion! Grab some pom poms and style her in any number of differently colored, shirts, skirts and team sweaters!
Use your mouse to click on and through the floating clothing, hair, background, pom poms and matching outfits for this fancy, fun babe.


text:
Павло́ Миха́йлович Матвіє́нко  — український радянський діяч. Депутат Верховної Ради УРСР 1-го скликання (1938–1941).

Біографія
Народився  року в родині робітника в слободі Микитівка, тепер село Микитівка, Красногвардійський район, Бєлгородська область, Росія. У 1928 році вступив до комсомолу.

У 1929–1931 роках — підручний котельника паровозного депо станції Попасна на Луганщині. З 1931 року — кондуктор кондукторського резерву залізничної станції Попасна (станції імені Лазаря Мойсейовича Кагановича). Обирався заступником секретаря комсомольської організації кондукторського резерву станції Попасна.

З 1934 року — в Червоній армії. Служив прикордонником Гродеківського прикордонного загону імені Л.М. Кагановича на Далекому Сході. У 1935 році був обраний комсомольським організатором прикордонної застави Турий Ріг на березі озера Ханка. У 1936 році відзначився у боях з маньчжурськими та японськими військами на радянській границі.

У 1938 році — слухач диспетчерських курсів при Управлінні Північно-Донецької залізниці у місті Артемівську; диспетчер відділу руху (експлуатації) станції імені Лазаря Мойсейовича Кагановича (місто Попасна) Ворошиловградської області.

26 червня 1938 року обраний депутатом Верховної Ради УРСР 1-го скликання по Кагановичській виборчій окрузі № 279 Ворошиловградської області.

Член ВКП(б).

З грудня 1938 року — 2-й секретар Ворошиловградського обласного комітету ЛКСМУ.

Після початку німецько-радянської війни — у Червоній армії: старший політрук, у розпорядженні Ворошиловградського міського військового комісаріату.

Зник безвісти (загинув) в серпні 1941 року.

Нагороди
 орден Червоного Прапора (2.03.1937)
 орден
 значок «Ударник сталінського призову»

Посилання
 Матвеенко Павел Михайлович, старший политрук, 1912 г/р. Сводная картотека  // Вебсайт «Память народа».

Джерела
 Матвієнко Павло Михайлович : облікова картка депутата Верховної Ради УРСР // ЦДАВО України, ф. Р-1, оп. 31, спр. 4, арк. 173.
 Список депутатів Верховної Ради УРСР першого скликання, обраних 26 червня 1938 року // ЦДАВО України, ф. Р-1, оп. 31, спр. 2, арк. 58.
 Список депутатів, обраних у Верховну Раду УРСР // Вісті [Рад депутатів трудящих УРСР] : газета. — Київ, 1940. — № 72 (5861). — 28 березня. — С. 1.
 Павел Михайлович Матвиенко // Сталинский путь : газета. — Кагановичск, 1938. — № 115 (486). — 20 мая. — С. 1.

Депутати Верховної Ради УРСР 1-го скликання
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With Joe Balogh, Sonia Curtis, Maria Alves, Domiziano Arcangeli, Justo Silva, Cléa Simões, Kieth Van Hoven, Philip Murray.
Italian zombie effort isn't half bad.
A group of young people visiting Brazil get involved in Macumba black magic rituals and unwittingly revive a posse of black stiffs hellbent on revenge against the slaveowners who done them wrong. Some underwhelming performances from a few of the lead cast are offset by some severe eye-gouging and head splitting.
One of Lenzi's few undead flicks, this is decent, but Nightmare City is certainly the strongest.
Also known as Demoni 3 and also Black Zombies.


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#65 Danny Gare
#64 Allan Globensky
#63 KC Scouts with Troy Treasure
#62 Robin Burns
#61 Denis Herron
#60 Dennis Maruk
#59 NY Rangers Goalies with George Grimm
#58 Steve Baker
Episode 37: John Van Boxmeer -- High Scoring D with Montreal, Buffalo, Colorado and Quebec.
John Van Boxmeer was a first round draft pick (14th overall) by the Montreal Canadiens in 1972 and went on to an outstanding 10-year NHL career as a high-scoring defenseman with the Habs, Colorado Rockies, Buffalo Sabres and Quebec Nordiques.
John was part of Montreal's 1975-76 Stanley Cup powerhouse team, playing behind Hall of Fame defensemen Larry Robinson, Guy Lapointe and Serge Savard. In search of consistent playing time, he was dealt to the Colorado Rockies in 1976 and established himself as a solid NHL blueliner with an improving, but struggling franchise.
When Scotty Bowman took over as GM in Buffalo he acquired John in exchange for Rene Robert and John delivered seasons of 51, 68 and 69 points from 1979-80 to 81-82. By 1984, however, injuries would take their toll and his playing career ended -- but he soon embarked on a successful 25-year coaching career in the NHL, AHL, IHL and Swiss Elite Leagues. He is now a pro scout with the Sabres.
John has great insights on his career at all levels and excellent stories to tell about hockey legend like Guy Lafleur and Bobby Orr. He even recalls his infamous TKO loss to Dave "The Hammer" Shultz in 1976.
Host: Mark Willand
Mark Willand
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Kenneth Bainbridge
Last Updated: Jul 10, 2019 See Article History
Originally published in the Britannica Book of the Year. Presented as archival content. Learn more.
This article was originally published in the Britannica Book of the Year, an annual print publication that provides an overview of the year's most-notable people and events. Unlike most articles on Britannica.com, Book of the Year articles are not reviewed and revised after their initial publication. Rather, they are presented on the site as archival content, intended for historical reference only.
Kenneth Bainbridge, U.S. physicist and director of the Trinity test, the first test explosion of the atomic bomb, which took place in the remote Jornado del Muerto desert in central New Mexico on July 16, 1945; he later served as chairman of the physics department at Harvard University and opposed nuclear weapons testing (b. July 27, 1904--d. July 14, 1996).
This article was most recently revised and updated by Karen Sparks, Director and Editor, Britannica Book of the Year.
Gerald Murphy
Gerald Murphy and Sara Murphy: Gerald Murphy, the son of the founder of the Mark Cross Company, a New York leather-goods and specialty store, graduated from Yale University (1912) and attended the Harvard School of Landscape Design (1918–20). Sara Wiborg, from a well-to-do Cincinnati family, attended private schools in Europe…
Lee Shubert
Shubert Brothers: …oldest of the brothers was Lee (originally Levi) Shubert (b. March 15, 1875, Russia—d. Dec. 25, 1953, New York, N.Y., U.S.). Sam S. Shubert (b. 1879, Russia—d. May 12, 1905, Harrisburg, Pa., U.S.) was the middle brother, and Jacob J. (or Jake) Shubert (b. Aug. 15, 1880, Russia—d. Dec. 26,…
Elizebeth S. Friedman
William F. Friedman and Elizebeth S. Friedman: Elizebeth Smith majored in English at Hillsdale (Michigan) College (B.A., 1915). They met at the Riverbank Laboratories (Geneva, Illinois), where they both eventually became involved in cryptology, working often for the government in decoding diplomatic messages. In 1917–18 William served in the U.S. Army, partly…
July 14, 1996 (aged 91)
National Academy of Sciences - Biography of Kenneth Tompkins Bainbridge


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How To Get Rich – Aleisha McCormack
By Lisa Clark
The most impressive thing about How To Get Rich is the first thing you notice when you sit down; a pair of actual airline chairs sitting on stage. They were apparently leant to the production by Virgin airlines and with the large monitor make up a simple but luxurious looking Fringe set. My main mistake was not paying attention to the show's blurb in the programme. So that it did not turn out to be a wealth creating seminar spoof but was actually a one woman play about going to get a man called Richard.
That was it really, Aleisha McCormack, the writer performer of the piece was on a plane going to the UK to meet up with a man she'd fallen for over the internet and was anxious about how it was going to turn out. The story itself was a bit too thin, we learned nothing about why she loved Richard, apart from his reliability, of how their love blossomed over the 5 months they'd been skyping or what really motivated Aleisha to spend a lot of money and to risk a new job and humiliation to go to the other side of the world to meet a man. The moral of this tale seems to be that getting a man is the most important reason to do anything.
Most of the play involves Aleisha on a plane chatting to the person next to her about her life and anxieties. She has broken this up by playing a couple of characters, her aunty and her friend who are both rather vulgar characters and are less than supportive. I guess they are there to make you feel sorry for Aleisah and be on her side, but I found her selfish character so annoying that it was very hard for me to sympathise with her situation.
Another thing that broke up the performance was a surprise guest appearance on the monitor (sadly not used to provide samples of her skyping with Rich) by 'Australian media personality' Deborah Hutton who sort of acts as a guardian angel to Aleisha who dreams of being a TV presenter. It's Deborah who finally gives Aleisha the sensible advice to stop worrying and if things don't work out she should just get on with her life.
This was a pretty light and fluffy soufflé of a show that would suit a girls' night out or hen's night, but it left me hungry for something a bit meatier. I really wanted to like this show but the laughs that were there were not enough to make up for its shortcomings. A major aspect that lost me was her brazilian waxing story. I know they titillate the crowd but after several years of these tales, it's getting a bit tiresome. They seem to be becoming the female equivalent of a male comedian talking about his dick.
I know that as a reviewer, you're not supposed to imagine what the play was not, but if the first half had been more about why and how Aleisha was on the plane, with a more compelling backstory and then only after the crisis of his lack of communication in Thailand the alarm bells started going off in the last part, it would have been much more dramatically interesting, instead of things going back and forth all the way through.
I'm guessing that this show is so autobiographical, (these things did actually happen to Aleisha) that it might be a bit hard for her to see the wood for the trees. Most experienced comedians know that if life isn't that interesting that you can take 'dramatic licence' to pep it up. Still for a debut Fringe Festival show it was fairly polished and entertaining enough for a mainstream crowd.
This show has finished its run
Here's the info about it http://www.melbournefringe.com.au/fringe-festival/show/how-to-get-rich/
Author adminPosted on October 9, 2012 Categories Melbourne Fringe 2013, ReviewsTags Aleisha McCormack, Melbourne Fringe Festival
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Meet the 2018 Cambridge News Business Excellence Awards finalists
These companies are in the running for the big prizes
Matt Gooding
The 2018 Cambridge News Business Excellence Awards finalists have been revealed
As ever the judging process for this year's Business Excellence Awards included a mixture of the well-known and the not-so-well known.
Our 2018 finalists include some companies whose stories have been told on numerous occasions on these pages and beyond, along with others that rarely enjoy time in the limelight. In all cases, it was a pleasure to hear what they've been up to in the last 12 months.
Cambridge News Business Excellence Awards 2018
Without wishing to sound too twee, what unites our finalists is their desire to make a difference, whether that's for their customers, staff, society as a whole, or all of the above. The other common theme is aspiration, an ambition to do more and do it better, which has been a hallmark of the Cambridge cluster over the years.
The winners will be revealed on Thursday, March 22 at our gala awards evening at King's College, where the special guest will be John Pienaar, the BBC's deputy political editor. For now, take a look at the companies in the running for the big prizes.
Biostrata
The Biostrata team
With a team of former scientists and marketing professionals, Biostrata has carved a niche for itself as the go-to marketing agency for life sciences companies.
"Cambridge is the perfect place for us to be, and our clients include a range of Cambridge companies, as well as those based in Europe and the US," says managing director Paul Avery.
Founded five years ago, Biostrata has turned a profit every year, and enjoyed 30-40 per cent yearly growth. It is based in Histon.
"The sweet spot for us in terms of clients is companies selling technology to pharmaceutical or life science businesses," Paul adds.
RXCelerate
Drug discovery is a long and notoriously expensive process, but RXCelerate wants to change that.
The consultancy firm provides its experts to pharmaceutical companies of all shapes and sizes to work on specific drug discovery projects, thus cutting down costs dramatically. The Babraham firm counts three of the world's top five pharma firms among its client list, and has grown to £3m in revenue in just four years, turning a healthy profit too.
"We want to change the way people think about drug development, you don't need a big building and a massive team of researchers," says RXCelerate's David Grainger.
Video content is everywhere these days, you only have to look at the News website to see that. But the sheer volume of promotional films means it's harder than ever to get noticed, which is where Somersault comes in.
The Sawston creative agency, which has worked with the likes of BAE Systems, Sport England and David Lloyd Health Clubs in the past, provides high quality promotional video content to clients in a range of sectors, and wants to become the world's number one digital creative agency.
"Cambridge isn't known as a heartland for creative companies, but we like to think we're putting the city on the map as a new area of creativity," says CEO Colin Miles.
CAMBRIDGE JUDGE HIGH GROWTH AWARD
Cambridge Judge Business School Entrepreneurship Centre
Giving public service organisations access to better systems is the name of the game at Arcus, a company that has grown 491 per cent in the last four years.
The company now offers more than 50 products and services covering a wide range of public service provision, and has been growing its software as a service offering to help it stand out in what co-founder Denis Kaminskiy describes as a highly competitive market place.
"We consider ourselves part of the Cambridge eco-system, and being recognised in these awards is a great boost for our team," Kaminskiy says.
Cambridge Design Partnership
Tucked away in a development of converted barns in Toft, you might not be aware technology and product design firm Cambridge Design Partnership exists, but its work can be found in products from big names such as Avon, Dulux, and Pyrex.
The company having enjoyed 35 per cent growth in the last financial year, and partner and co-founder Mike Cane says the company has ambitious plans for the future, including the addition of an office on the East coast of the US, to complement its team in Palo Alto
"We're focusing on accessing bigger customers, entering new markets and expanding the services we offer," he says.
Cambridge Wine Merchants
"For 25 years I've been trying to take away the terror of going into a wine shop," says Cambridge Wine Merchants founder Hal Wilson. Anyone who has been into one of his shops or wine bars would probably agree this he's been quite successful so far.
In terms of growth, CWM has been upscaling its business so it supplies more hotels, restaurants and university colleges, as well as exploiting the hybrid bar/shop model the company operates at its flagship Bridge Street store at other locations.
"We're not necessarily the place you go if you want your favourite brand, because we love sharing new wines which are really excellent with our customers," says Hal.
The Vaiopak Group
The Vaiopak Group: cup specialists
Vaiopak founder Joe Fogel came to the judging session armed with a big stack of disposable coffee cups. They look very similar to the type you'd find at except with one key difference; they can be recycled.
That's because Vaiopak, which specialises in making personalised disposable cups for independent coffee shops, has an exclusive license for a new type of coating technology for paper cups which is fully recyclable, unlike the current options on the market. Marks and Spencer is an early customers, and if other big names get on board the Saffron Walden company's rapid growth could continue. Watch this space.
BARCLAYS LARGE BUSINESS OF THE YEAR
Aveva's Engage software
It's been a terrific 12 months for Aveva, as one of Cambridge's biggest and best-established employers continued to lead the way in its field.
Though the last few years haven't been kind to the engineering software firm's key markets, with sectors such as oil and gas suffering, Aveva has ridden out the storm and, with conditions now improving, has enjoyed a strong year, with its last interim results showing a 11.5 per cent increase in revenue and a 13 per cent profit bump.
And it is poised to continue to grow after completing a transformational merger with the software business of French firm Schneider Electric.
Horizon Discovery Group
One of the jewels in the crown of the Cambridge life science cluster, Horizon's quest for world domination continues at a pace.
Based at Cambridge Research Park, it provides tools and services to researchers working in gene editing and gene manipulation, and the last year has seen it seal the £65m purchase of US competitor Dharmacon. Revenues have continued to rocket, and the company is set to better the impressive growth of 51 per cent recorded in 2016.
Outgoing CEO Darrin Disley told the judges: "Seventy five per cent of our revenue now comes from products, and customer numbers are up dramatically in the last year."
Thorlabs
Thorlabs has come a long way since it was founded in a New Jersey basement. It is now a leading supplier of optical equipment offering a bewildering array of products to its customers.
Worldwide sales are worth over $200m, and Thorlabs' Buki Dada says: "A lot of our growth is coming from OEMs using our products and building them into their own."
Its Ely operation is a big part of the company's success, as are its famous 'lab snacks', little boxes of treats which get sent out with orders. Who wouldn't want to receive one of those?
PURE EMPLOYER AWARD
Work/life balance is key at publishing firm CPL, according to the company's managing director Mike Sewell.
"We want to support and empower our staff, and if we can do that it's good for the business too," he says.
The publishing company offers a wide range of print and online services to clients which include Darley, Sheikh Mohammed's Newmarket stud. Turnover is £7m, up from £3m five years ago.
Sewell says CPL has put a big focus on training and development since a management buyout in 2016. The company has also introduced a shorter working day, which is sure to have gone down well with employees.
CPS Building Services
"Our employees asked us for bigger vans, so we brought them," says Liam Connelly, commercial director at CPS Building Services. "It's a real family feel at the company, everyone does their bit."
Established 21 years ago, CPS provides a range of electrical, mechanical and maintenance services to clients including the Cambridge Universities estates management team. As well as bigger vans, the company looks after its staff with training and support, as well as backing charitable initiatives. To mark its 21 birthday, it hopes to raise £21,000 for the Alzheimer's Society through a year-long programme of events.
Genie Ventures
Table football at Genie Ventures
With a staff retention rate of more than 95 per cent, marketing and publishing firm Genie Ventures is obviously doing its bit to keep its, er, genies, happy.
"The key thing for us is that our staff feel trusted," says Sarah Sutton, the company's head of people development. "We have regular updates about how the company is doing, and everyone is trusted to work flexibly so their hours fit in with their lives."
A wide range of perks available in its central Cambridge office, while employees are encouraged to sign up to the Genie Academy where they can learn new skills.
CAMBRIDGE BID INDEPENDENT RETAILER AWARD
Cambridge BID
Finn Jordan
Sarah Jordan was just 24 when she took over the beauty salon now known as Finn Jordan with business partner Claire Finn.
Despite having little experience of running a business, the pair have turned the Sussex Street salon into one of the most popular in the city centre, offering a wide range of treatments and products. The salon's high level of customer service saw it score 100 per cent in two mystery shopper visits organised by Cambridge BID last year.
"I stopped doing treatments myself in 2016, to give me more time to think strategically about the business," says Sarah, who is now hoping to develop a Finn Jordan line of beauty products.
Millers Music
Miller's Music
Giving away 21 pianos might not sound like the most credible of business plans for a music store, but this is what Cambridge's Millers Music did last year.
The shop, which has been trading in the city in one guise or another for over 160 years, donated the instruments to an array of schools and institutions in the region following its Nocturne for 21 Pianos concert, which saw 21 local young musicians play 21 pianos simultaneously in the grand surroundings of King's College Chapel.
There are plenty of pianos in-store too, with a new showroom having been built to accommodate them, as well as the many other types of instrument available for sale or rent.
Podarok
Podarok – Bene't Street.
Podarok means gift in Russian, and manager Carrie Pluck brought some of the store's wares, which include purses, bags and various other trinkets, to show the judges.
The company sources its items from craftspeople locally and across the UK, meaning its stock is eclectic and unsual.
"We want people to go away after visiting us having enjoyed the experience," Carrie says. "We love the telling the stories of our stock and where it came from."
Committed Podarok fans can also listen to music which plays in the shop at home, as it's been made available as a Spotify playlist.
Stem+Glory
Stem + Glory 2 (Image: David Johnson)
Think vegan food in Cambridge and the name which immediately springs to mind is Stem + Glory.
The brainchild of CamYoga founder Louise Palmer-Masterton, the vegan café and restaurant opened last year on Mitcham's Corner, and has proved so popular that the company has since added a second site, in King Street, for those who need their vegan food fix.
Louise isn't stopping there, and having joined the Virgin CrowdBoost accelerator scheme she is finalising plans to take the brand national, starting with another restaurant in London. Today Cambridge, tomorrow the world…
HEWITSONS AWARD FOR BUSINESS INNOVATION
Hewitsons
Audio Analytic
Audio Analytic creating the 'language of sounds' - looks fun
The 'Shazam of sounds' is how Audio Analytic's sound-recognition system is often described, referring to the popular app that identifies songs by listening to them.
"We can make machines hear," says founder Chris Mitchell. Indeed the company has come up with a set of 'ideophones', a language of sounds which catalogues the properties of various noises. As you can imagine, this is pretty useful for devices such as burglar alarms, and the company's technology can be founded embedded in devices built by companies including Intel, Hive, and our very own Arm Holdings.
Having raised $5.5m in a Series A funding round last year, there's more to come from the Quayside firm.
Cydar
Cydar's surgical guidance system
"Would you be comfortable with a surgeon placing this in your aorta?," Cydar's Dr James Gough asked our judges, waving around a medical instrument several feet long.
The thought of such a device entering your body is not for the faint-hearted (sorry), but guiding instruments is one of the biggest challenges faced by doctors since away from open surgery to more non-invasive techniques. At the moment, surgeons usually have to rely on a 2D X-ray view for guidance, but Cydar has come up with a system that combines this with 3D CT scan images. The firm's cloud-based platform uses machine learning algorithms to map an individual patient's anatomy and pinpoint the location of instruments.
PervasID
Stock tracking is a big issue for many shops and medical facilities. PervasID thinks it has the answer in the form of RFID reader system which can be hidden in ceiling tiles.
For the unitiated, RFID tags are small, cheap tags which can be attached to items and emit a radio frequency, allowing them to be tracked. Such systems already exist, but PervasID believes it has come up with a superior version, and already has the customers, in retail and healthcare, to prove it.
"RFID typically only works over 1-2m, but in one shop we're tracking over 100,000 items in an area of 4,000 square metres," says founder Sithamparanathan Sabesan.
Leaning a new language properly can take the average person a lifetime, but Speechmatics has come up with a system that can do it in a matter of weeks.
The company managed to teach its system, which (unsurprisingly) uses machine learning techniques, Japanese in two and a half weeks to satisfy the demands of executives at a client.
"We're building the next generation of speech recognition, and providing an alternative to the systems developed by the tech giants," says CEO Benedikt von Thüngen.
ALLIA AWARD FOR SOCIAL ENTREPRENEURSHIP
Allia
Form the Future
Form the Future: Taking business into the classroom
What can we do about the skills crisis? It's a question that has businesses in Cambridge and beyond constantly scratching their heads, but one that rarely results in any tangible action.
Fortunately, Form the Future is here to help. "We help young people learn about the world of work, so that they can take confident decisions about what is right for them," says co-founder Michaela Esbach, and it turns out they're rather good at it.
Through a range of experience days, mentorship and work experience programmes, Form the Future has helped introduce children at hundreds of schools to new careers, doing particularly fine work in the area of STEM.
Levin Sources
From its small office in Shelford, Levin Sources is having a global impact in the field of artisanal and small scale mining.
The company helps ensure mineral companies' supply chains meet ethical and human rights standards, as the way small mines in developing countries are run is often problematic.
"We look at the issues that might occur in the supply chain and find ways of dealing with those issues," says founder Estelle Levin-Nally.
Levin Sources also works with NGOs and charities, and was part of a major project to help conserve the habitats of gorillas living in DR Congo.
The Edge Cafe
The Edge Café
Cambridge is full of cafés, but few have such a noble social mission as The Edge, which offers a route back into employment for people recovering from drug and alcohol problems.
"It's a safe place for people with drug or alcohol problems to come and work or volunteer," says Tom Jefford from the café. "They're doing positive things, and if you create that opportunity it really helps people integrate back into society."
As well as being somewhere to pick up some delicious coffee and cake, the Mill Road café acts as a hub for a wide variety of community and support groups.
PRICE BAILEY BUSINESS OF THE YEAR
Price Bailey
To be announced on the night.
BIOMED REALTY AWARD FOR BUSINESSPERSON OF THE YEAR
BioMed Realty
To be announced on the night
MEDIMMUNE AWARD FOR OUTSTANDING CONTRIBUTION
MedImmune
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In a medium bowl, toss the eggplant with the sesame oil, hoisin sauce, garlic, tamari, ginger and rice vinegar. Toss until all the eggplant is evenly coated, then tip the whole bowl into a large frying pan.
Fry on moderate heat until the eggplant is cooked through and has started to caramelise in places.
While the eggplant is frying, steam your bao buns according to the instructions on the packet (alternatively, cook your rice).
To serve, cut each bun in half and spread with the pine nut paste, then fill with the eggplant, cucumber strips and spring onion.
Sprinkle the sesame seeds and fresh chilli (to taste) on top of the buns before serving. Eat while steamin' (makes 3 serves).