197101, Санкт-Петербург, ул. Мира, д. 14.
127490, Москва, ул. Мусоргского, 4.
111123, Москва, ул. Новогиреевская, 3а.
Цель. Разработка метода выявления и количественного анализа (ОТ-ПЦР в реальном времени) для выявления генетических маркеров вируса Ласса - LASV-Fl. Материалы и методы. Для работы взяты все доступные в базе данных GenBank (https://www.ncbi.nlm.nih.gov/genbank/) последовательности вируса Ласса, которые были выровнены для идентификации консервативных сайтов с использованием программного пакета BioEdit 7.2.5 (IbisBiosciences, США). для апробации разработанного ПЦР-набора была использована контрольная панель РНК вируса Ласса и псевдовирусных частиц, 27 вирусных штаммов, относящихся к различным семействам, а также 37 образцов сывороток крови от пациентов с лихорадочными заболеваниями, отобранных в лечебных учреждениях Республики Гвинея в 2016-2018 гг., и 55 проб суспензий органов от многососковых мышей. Результаты и обсуждение. Аналитическая чувствительность метода варьировала от 103 до 105 копий/мл и имела 96,4 % диагностическую чувствительность, тогда как аналитическая и диагностическая специфичность составляли 100 %. показано, что разработанная методика может быть успешно применена на практике для обнаружения вируса Ласса в Гвинейской Республике, с использованием различных типов материала от мелких млекопитающих, включая цельную кровь и суспензии органов M. natalensis,а также образцы сывороток крови людей, собранных через 3-7 дней после начала заболевания. Сделано также предположение, что данный метод может быть использован для штаммов вируса Ласса, распространенных не только в Гвинее, но и на других эндемичных территориях, но данный факт необходимо подтвердить в дальнейших исследованиях.
1. Virus taxonomy: the classification and nomenclature of viruses: the online (10th) report of the ICTV [Internet]. (cited 03 Oct 2018). Available from: https://talk.ictvonlme.org/ictv-reports/ictv_onlinereport/.
2. Ogbu O., Ajuluchukwu E., Uneke C.J. Lassa fever in West African sub-region: an overview. J. Vector Borne Dis. 2007; 44(1):1- 11. PMID: 17378212.
3. Safronetz D., Lopez J.E., Sogoba N., Traore' S.F., Raffel S.J., Fischer E.R., Ebihara H., Branco L., Garry R.F., Schwan T.G., Feldmann H. Detection of Lassa virus, Mali. Emerg. Infect. Dis. 2010; 16(7):1123-6. DOI: 10.3201/eid1607.100146.
4. Ajayi N.A., Nwigwe C.G., Azmogu B.N., Onyire B.N., Nwonwu E.U., Ogbonnaya L.U., Onwe FI., Ekaete T., Gunther S.,Ukwaja K.N. Containing a Lassa fever epidemic in a resource-limited setting: outbreak description and lessons learned from Abakaliki, Nigeria (January-March 2012). Int. J. Infect. Dis. 2013; 17(11):e1011-6. DOI: 10.1016/i.iiid.2013.05.015.
5. Keenlyside R.A., McCormick J.B., Webb P.A., Smith E., Elliott L., Johnson K.M. Case-control study of Mastomys natalensis and humans in Lassa virus-infected households in Sierra Leone. Am. J. Trop. Med. Hyg. 1983; 32: 829-37.
6. Monath T.P., Newhouse V.F., Kemp G.E., Setzer H.W., Cacciapuoti A. Lassa virus isolation from Mastomys natalensis rodents during an epidemic in Sierra Leone. Science. 1974; 185:263-5. PMID: 4833828.
7. Safronetz D., Sogoba N., Lopez J.E., Maiga O., Dahlstrom E., Zivcec M., Feldmann F., Haddock E., Fischer R.J., Anderson J.M., Munster VJ., Branco L., Garry R., Porcella S.F., Schwan T.G., Feldmann H. Geographic distribution and genetic characterization of Lassa virus in sub-Saharan Mali. PLoS Negl. Trop. Dis. 2013; 7(12):e2582. DOI: 10.1371/journal.pntd.0002582.
8. Richmond J.K., Baglole D.J. Lassa fever: epidemiology, clinical features, and social consequences. BMJ. 2003; 327(7426):1271-5. DOI: 10.1136/bmj.327.7426T271.
9. Monath T.P., Mertens P.E., Patton R., Moser C.R., Baum J.J., Pinneo L., Gary G.W., Kissling R.E. A hospital epidemic of Lassa fever in Zorzor, Liberia, March-April 1972. Am. J. Trop. Med. Hyg. 1973; 22(6):773-9. DOI: 10.4269/ajtmh.1973.22.773.
10. Macher A.M., Wolfe M.S. Historical Lassa fever reports and 30-year clinical update. Emerg. Infect. Dis. 2006; 12:835-7. DOI: 10.3201/eid1205.050052.
11. Asogun D.A., Adomeh D.I., Ehimuan J., Odia I., Hass M., Gabriel M., Olschlager S., Becker-Ziaja B., Folarin O., Phelan E., Ehiane P.E., Ifeh V.E., Uyigue E.A., Oladapo Y.T., Muoebonam E.B., Osunde O., Dongo A., Okokhere P.O., Okogbenin S.A., Momoh M., Alikah S.O., Akhuemokhan O.C., Imomeh P., Odike M.A., Gire S., Andersen K., Sabeti PC., Happi C.T., Akpede G.O., Gunther S. Molecular diagnostics for Lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation. PLoS Negl. Trop. Dis. 2012; 6(9):e1839. DOI: 10.1371/journal.pntd.0001839.
12. Olschlager S, Lelke M, Emmerich P, Panning M, Drosten C, Hass M, Asogun D, Ehichioya D, Omilabu S, Gunther S. Improved Detection of Lassa Virus by Reverse Transcription-PCR Targeting the 5' Region of S RNA. J. Clin. Microbiol. 2010; 48(6):2009-13. DOI: 10.1128/JCM.02351-09.
13. Tyagi S, Kramer F.R. Molecular beacons: probes that fluoresce upon hybridization. Nat Biotechnol. 1996; 14:303-8. DOI: 10.1038/nbt0396-303.
14. Van Pelt-Verkuil E., van Belkum A., Hays J.P. Principles and technical aspects of PCR amplification. NY: Springer Science; 2008. 332 p. DOI: 10.1007/978-1-4020-6241-4.
15. Kibbe WA. OligoCalc: an online oligonucleotide proper¬ties calculator. Nucleic Acids Res. 2007; 35(Suppl. 2):W43-46. DOI: 10.1093/nar/gkm234.
16. Dedkov V.G., Magassouba N.F., Safonova M.V., et al. 2016. Development and evaluation of a real-time RT-PCR assay for the detection of Ebola virus (Zaire) during an Ebola outbreak in Guinea in 2014-2015. J. Virol. Methods. 2016; 228:26-30. DOI:10.1016/j.jviromet.2015.11.007.
17. Maniatis T., Fritsch E.F., Sambrook J. Molecular cloning, a laboratory manual. Cold Spring Harbor laboratory. 2-ed. Cold Spring Harbor Lab. Press; 1989. 1885p.
18. Cheng Y, Niu J., Zhang Y, Huang J., Li Q. Preparation of his-tagged armored RNA phage particles as a control for real-time reverse transcription-PCR detection of severe acute respiratory syndrome coronavirus. J. Clin. Microbiol. 2006; 44(10):3557-61. DOI: 10.1128/JCM.00713-06.
19. Pasloske B.L., Walkerpeach C.R., Obermoeller R.D., Winkler M., Du Bois D.B. Armored RNA technology for production of ribonuclease-resistant viral RNA controls and standards. J. Clin. Microbiol. 1998; 36(12):3590-4. PMID: 9817878.
20. Chemillod P., Schibler M., Vieille G., Cordey S., Mamin A., Vetter P., Kaiser L. Ebola virus disease diagnosis by real-time RT- PCR: a comparative study of 11different procedures. J. Clin. Virol. 2016; (77):9-14. DOI: 10.1016/j.jcv.2016.01.017.
21. Newcombe R.G. Two-Sided Confidence Intervals for the Single Proportion: Comparison of Seven Methods. Statistics in Medicine. 1998; 17:857-72.
22. Wilson E.B. Probable Inference, the Law of Succession, and Statistical Inference. Journal of the American Statistical Association. 1927; 22:209-12. DOI: 10.1080/01621459.1927.10502953.
23. Bausch D.G., Rollin P.E., Demby A.H., Coulibaly M., Kanu J., Conteh A.S., Wagoner K.D., McMullan L.K., Bowen M.D., Peters C.J., Ksiazek T.G. Diagnosis and clinical virology of Lassa fever as evaluated by enzyme-linked immunosorbent assay, indirect fluorescent-antibody test, and virus isolation. J. Clin. Microbiol. 2000; 38(7):2670-77.
24. Niklasson B.S., Jahrling P.B., Peters C.J. Detection of Lassa virus antigens and Lassavirus-specific immunoglobulins G and M by enzyme-linked immunosorbent assay. J. Clin. Microbiol. 1984; 20(2):239-44. PMID: 6386846.
25. Jahrling P.B., Niklasson B.S., McCormick J.B. Early diag-nosis of human Lassa fever by ELISA detection of antigen and anti-body. Lancet. 1985; 1(8423):250-2. PMID: 2857321.
26. Gunther S., Lenz O. Lassa Virus. Crit. Rev. Clin. Lab. Sci. 2004; 41(4):339-90. DOI: 10.1080/10408360490497456.
27. Drosten C., GottigS., Schilling S., Asper M., Panning M., Schmitz H., Gunther S. Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR. J. Clin. Microbiol. 2002; 40:2323-30. DOI: 10.1128/JCM;40.7.2323-2330.2002.
28. Trappier S.G., Conaty A.L., Farrar B.B., Auperin D.D., McCormick JB., Fisher-Hoch S.P. Evaluation of the polymerase chain reaction for diagnosis of Lassa virus infection. Am. J. Trop. Med. Hyg. 1993; 49(2):214-21. PMID: 8357084.
29. Demby A.Hi, Chamberlain J., Brown D.W., Clegg C.S. Early diagnosis of Lassa fever by reverse transcription-PCR. J. Clin. Microbiol. 1994; 32:2898-903. PMID: 7883875.
30. Trombley A.R., Wachter L., Garrison J., Buckley-Beason V.A., Jahrling J., Hensley L.E., Schoepp R.J., Norwood D.A., Goba A., Fair J.N., Kulesh D.A. Comprehensive Panel of Real-Time TaqMan™ Polymerase Chain Reaction Assays for Detection and Absolute Quantification of Filoviruses, Arenaviruses, and New World Hantaviruses. Am. J. Trop. Med. Hyg. 2010; 82(5):954-60. DOI: 10.4269/ajtmh.2010.09-0636.
31. Bowen M.D., Rollin P.E., Ksiazek T.G., Hustad H.L., Bausch D.G., Demby A.H., Bajani M.D., Peters C.J., Nichol S.T. Genetic Diversity among Lassa Virus Strains. J. Virol. 2000; 74(15):6992-7004. PMID: 10888638.
32. Poch O., Blumberg B.M., Bougueleret L., Tordo N. Sequence comparison of five polymerases (L proteins) of unsegmented negative-strand RNA viruses: Theoretical assignment of functional domains. J. Gen. Virol. 1990; 71:1153-62. DOI: 10.1099/0022-1317-71-5-1153.
33. Poch O., Sauvaget I., Delarue M., Tordo N. Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO J. 1989; 8:3867-74.


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The knife is a short range weapon to stab enemies with. If an enemy is far away, press the attack button to throw the knife at them.
The rod is a powerful weapon to smash enemies over the head with. Once you hit an enemy a couple of times, the rod will break and you will be left with a smaller piece, this smaller piece works like the knife.
The stone is a simple and fairly weak weapon, just pick it up and then press the attack button to throw it at an enemy. Also available in exciting brown colours!
The club acts a lot like the rod, but won't break up after several hits on an enemy.
Only found in level 5, the torch will set opponents on fire when you strike them with it.
B. Knife is only available in the second level, and you can only get it by knocking out of Butcher's (the boss of that level) hands. It acts like the club.
Barrels come in various shapes and sizes, and can be broken to reveal items. But you can also pick them up and throw them at enemies if you move up to them as close as you can and press the attack button. You cannot run or jump when holding a barrel.
Grenades can be picked up and then thrown at enemies, and will either explode on contact with an enemy or after a few seconds. They are great for taking down large groups of opponents.
Dynamite can be picked up and thrown, once it is thrown it's fuse will light and a couple of seconds after this, it detonates. Any opponents near the resulting explosion will get hurt.
Simply called "gun" this firearm can fire up to six shots. It is the weakest firearm in the game, but three shots in a row is usually enough to make an enemy fall over. Once the ammo for this weapon is depleted, you can pick it up again and throw the gun at an enemy.
The shotgun can fire up to six shots and has a wide blast radius. It is powerful enough to take out groups of enemies. Once the ammo for this weapon is depleted, you can pick it up again and throw the shotgun at an enemy.
The rifle is another gun which has a six shot load. It fires slowly but does quite a bit of damage. Once it's ammo is depleted, you can pick it up again and club an enemy with it.
The Uzi fires lots of bullets in bursts, and several shots will cause an enemy hit by them to fall down. This weapon is extremely useful against level 3's boss, Hogg. When the ammo for it is depleted, pick it up again to throw it at opponents.
The M-16A1 is a large automatic rifle that sprays bullets everywhere when you press the attack button. Once its ammo is depleted it can be used as a club when picked up again. It is also the most difficult weapon to get and is the most rarely seen in the game, only appearing in smashed objects randomly.
The bazooka is a four shot wonder. Any enemy hit by a bazooka shot will suffer massive damage. Whenever you continue, you restart with one of these, which is most generous.
Whilst not exactly a weapon, ammo is pretty important. Pick it up, and then the next weapon you pick up will have it's ammo refilled. So use up every bullet in the Uzi, then go pick the ammo up, then go pick the Uzi up again and it will be full.
... to bring on the ultimate weapon: the Cadillac! Steer the car around and mow down every enemy you see. You can only get the radio in the third level, so it means you can only drive the car around in that level as well.


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redpajama_set_name: RedPajamaGithub


text:
Question: Why is to kill a mockingbird called to kill a mockingbird?
Why is To Kill a Mockingbird banned?
To Kill a Mockingbird is one of the most frequently challenged books in the US due to its themes of rape and use of profanity and racial slurs. Unlike the previous case, the book was banned due to the accumulation of complaints over the years.
What was To Kill a Mockingbird originally called?
After the "Watchman" title was rejected, it was re-titled Atticus but Lee renamed it To Kill a Mockingbird to reflect that the story went beyond a character portrait. The book was published on July 11, 1960. Since the original publication, the book has never been out of print.
Why Boo Radley is a Mockingbird?
Boo Radley is a mockingbird because he is sweet and innocent even though he is misjudged by society. He is a gentle, caring man who loves the children. He showers the children with gifts and even saves their lives when they are attacked by Bob Ewell.
Why is To Kill a Mockingbird so important?
' A haunting portrait of race and class, innocence and injustice, hypocrisy and heroism, tradition and transformation in the Deep South of the 1930s, Harper Lee's To Kill a Mockingbird remains as important today as it was upon its initial publication in 1960, during the turbulent years of the Civil Rights movement.
Why is 1984 a banned book?
Why it was banned: George Orwell's 1984 has repeatedly been banned and challenged in the past for its social and political themes, as well as for sexual content. Additionally, in 1981, the book was challenged in Jackson County, Florida, for being pro-communism.
Is To Kill a Mockingbird appropriate for 11 year old?
A must-read for 13+
It is not inappropriate for children under thirteen, but the messages and reading level mean that a person must be enough advanced to get everything out of it.
Is To Kill a Mockingbird historically accurate?
While To Kill A Mockingbird is not autobiographical, there are similarities between the novel and Lee's life. The book is set in Maycomb, Alabama, the fictional name for Monroeville, where Lee grew up. Like the main character Scout, Lee was a tomboy who was uncomfortable with traditional femininity.
What is Atticus famous quote?
"Courage is not a man with a gun in his hand. It's knowing you're licked before you begin but you begin anyway and you see it through no matter what. You rarely win, but sometimes you do." "You rarely win, but sometimes you do."
How much money did Harper Lee make from To Kill a Mockingbird?
According to a 2013 court case filed against Lee's former agent Sam Pinkus, she earned $2.5 million in royalties from To Kill A Mockingbird between July 2009 and July 2010. Assuming that time frame represents an average gross from the book, Lee earned over $9,000 per day off of the novel.
How does Boo Radley lose his innocence?
Boo Radley was one of the characters who loss his innocence. He lost his innocence when he was just a kid. As a teenager, Boo experienced trouble with the law and for his consequences, his father imprisoned him in his own house. Radley crushed Boo's child-like innocence.
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Who killed Bob Ewell?
On the night of the Halloween pageant Bob follows the children home and attacks them but Boo saves Jem and Scout but fatally stabs Bob Ewell. Atticus is convinced Jem killed Bob Ewell but Heck Tate (the sheriff) points out that Jem isn't strong enough and after Bob broke his arm he wouldn't have been able to stab him.
Why did Boo Radley stab his father?
Boo did stab his father with the scissors. His father was domineering (and there are suggestions that he was emotionally abusive). Boo stabbed him because he was angry. Boo supossedly stabbed his father in the leg with a pair of scissors when he was a teenager, then returned calmly to clipping articles in the paper.
Did they really shoot the dog in To Kill a Mockingbird?
Let's dig a little deeper as we Remember this Moment in TO KILL A MOCKINGBIRD. THAT MOMENT: Atticus takes aim at the rabid dog, removing his glasses. Once he's sure, he kills the dog instantly with one shot.
What did To Kill a Mockingbird teach you?
The story of To Kill a Mockingbird also teaches us about what the Deep South was like during the Great Depression. The South has changed somewhat since then, but there is still a lot of racial prejudice. The injustice suffered by Tom Robinson conveys a lesson that everyone should receive equal treatment under the law.
How Has To Kill a Mockingbird changed the world?
The book was assigned widely in American schools and quickly became a literary and popular favorite — worldwide sales topped 40 million. Lee won the Pulitzer Prize for her work. The book was also quickly turned into an Academy Award-winning movie starring Gregory Peck.
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redpajama_set_name: RedPajamaCommonCrawl


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Great'rex History, Family Crest & Coats of Arms
The Anglo-Saxon name Great'rex comes from the family having resided in an area that was referred to as the great ridge. Great'rex is a topographic surname, which was given to a person who resided near a physical feature such as a hill, stream, or in this case a ridge. [1]
Another source postulates that the name was from "Greatorick, from Gayteric, the old form of Catterick, Yorkshire, in which county the name remains common." [2]
And two sources claim the name is from Great Rocks; a hamlet, Tideswell, Derbyshire. [3] [4] This latter source dives into more detail: "the Derbyshire name of Greatorex is evidently derived from Great Rocks, a hamlet in the parish of Wormhill. Greatrix and Gratrix are now Lancashire forms of the name." [4]
And yet another source claims the name is from Greterakes, a place name in the Domesday Book of 1086. [5]
Early Origins of the Great'rex family
The surname Great'rex was first found in Essex where Augustine Brandon and Elizabeth Greatracks, of Westham, Essex married in 1382. [6]
Early History of the Great'rex family
This web page shows only a small excerpt of our Great'rex research. Another 90 words (6 lines of text) covering the years 1647, 1659, 1697, 1743, 1625, 1675, 1712, 1629, 1683, 1629, 1628, 1683 and 1666 are included under the topic Early Great'rex History in all our PDF Extended History products and printed products wherever possible.
Great'rex Spelling Variations
Great'rex has been spelled many different ways. Before English spelling became standardized over the last few hundred years, spelling variations in names were a common occurrence. As the English language changed in the Middle Ages, absorbing pieces of Latin and French, as well as other languages, the spelling of people's names also changed considerably, even over a single lifetime. Spelling variants included: Gratrix, Greatrix, Greatrex, Great-Rex, Greatorix, Greatorex and many more.
Early Notables of the Great'rex family (pre 1700)
Distinguished members of the family include Ralph Greatorex (c.1625-1675), an English mathematical instrument maker and apprentice of London clockmaker Elias Allen, his name appears in Pepys's Diary. His date of death is uncertain as the Dictionary of National Biography claims he died as late as 1712. Valentine Greatrakes (1629-1683), whose name...
Another 50 words (4 lines of text) are included under the topic Early Great'rex Notables in all our PDF Extended History products and printed products wherever possible.
Migration of the Great'rex family to Ireland
Some of the Great'rex family moved to Ireland, but this topic is not covered in this excerpt.
Migration of the Great'rex family
In an attempt to escape the chaos experienced in England, many English families boarded overcrowded and diseased ships sailing for the shores of North America and other British colonies. Those families hardy enough, and lucky enough, to make the passage intact were rewarded with land and a social environment less prone to religious and political persecution. Many of these families became important contributors to the young colonies in which they settled. Early immigration and passenger lists have documented some of the first Great'rexs to arrive on North American shores: George, Henry and Lawrence Greatrake settled in Delaware in 1813.
Contemporary Notables of the name Great'rex (post 1700) +
Stanley "Stan" Greatrex, English professional motorcycle speedway rider in the 1930s, National League Champion in 1938
Neil Greatrex (b. 1951), English former miner, trade unionist, and the former president of the Union of Democratic Mineworkers (UDM); he was found guilty of embezzlement
John Greatrex (b. 1936), English cricketer for Norfolk in the 1970s
Thomas James "Tom" Greatrex (b. 1974), British Labour Party politician, Shadow Minister for Energy (2011-2015), Member of Parliament for Rutherglen and Hamilton West (2010-2015)
Tim Greatrex, British television executive
^ Harrison, Henry, Surnames of the United Kingdom: A Concise Etymological Dictionary Baltimore: Geneological Publishing Company, 2013. Print
^ Barber, Henry, British Family Names London: Elliot Stock, 62 Paternoster Row, 1894. Print.
^ Guppy, Henry Brougham, Homes of Family Names in Great Britain. 1890. Print.
Great'rex (English)


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Ectopic pregnancy occurs when a fertilized egg implants in tissue outside of the uterus, and the placenta and fetus begin to develop there. The most common site is within a fallopian tube. However, ectopic pregnancies can rarely occur in the ovary, the abdomen, and in the lower portion of the uterus (the cervix).
Ectopic pregnancies are usually caused by conditions that obstruct or slow the passage of a fertilized ovum (egg) through the fallopian tube to the uterus. This may be caused by a physical blockage in the tube. Ectopic pregnancy may also be caused by failure of the zygote (the cell formed after the egg is fertilized) to move down the tube and into the uterus.
Most cases are a result of scarring caused by previous tubal infection or tubal surgery. Up to 50% of women with ectopic pregnancies have a medical history of salpingitis or PID (pelvic inflammatory disease). Some ectopic pregnancies can be traced to congenital tubal abnormalities, endometriosis, tubal scarring and kinking caused by a ruptured appendix, or scarring caused by previous pelvic surgery and prior ectopic pregnancies. In a few cases, the cause is unknown.
On occasion, a woman will become pregnant after elective tubal sterilization. The risk of an ectopic pregnancy occurring in this situation may reach 60%. Women who have had surgery to reverse previous tubal sterilization in order to become pregnant also have an increased risk of ectopic pregnancy when reversal is successful.
The administration of hormones, specifically estrogen and progesterone, can slow the normal movement of the fertilized egg through the tubal epithelium and result in implantation in the tube. Women who become pregnant despite using progesterone-only oral contraceptives have a 5-fold increase in the ectopic pregnancy rate.
Women who become pregnant despite using progesterone-bearing IUDs also have an increased risk of ectopic pregnancy. Ectopic pregnancy rates for those who become pregnant despite non-medicated IUD are 5%, while the rate for medicated IUD users who become pregnant despite the device is 15%. Note that these rates only refer to percents of the tiny proportion of women who become pregnant while using these methods - they do not refer to women who have once used these methods and later become pregnant, or to the percent of women who become pregnant while using these methods.
The "morning after pill" is associated with a 10-fold increase in risk of this condition when its use fails to prevent pregnancy.
Ectopic pregnancies occur from 1 in every 40 to 1 in every 100 pregnancies. This rate increased four-fold between 1970 and 1992.
Increased risk is associated with women who have a history of salpingitis or PID, tubal surgery of any type (including tubal ligation and its reversal), or prior ectopic pregnancy.
A pelvic examination may reveal uterine adnexal (Fallopian tube or ovary region) tenderness.
There is usually a positive pregnancy test. o Urine HCG (qualitative) tests may be falsely negative in up to 17.5% of them. o In contrast, serum HCG (quantitative) tests have only a 2% incidence of false-negative results.
A hematocrit test may be normal or decreased.
The white blood count may be normal or increased.
A culdocentesis may be performed to determine if free blood is present in the abdomen.
An ultrasound (transvaginal ultrasound or pregnancy ultrasound) illustrates an empty uterus. Products of conception may be evident elsewhere.
A laparoscopy or a laparotomy may be necessary for adequate diagnosis.
A D and C may be indicated to rule out a nonviable intrauterine pregnancy.
Serum progesterone - a value of 25ng/mL or more is, 98% of the time, associated with a normal pregnancy in the uterus, while a value of less than 5ng/mL indicates that the pregnancy, regardless of location, is not going to be successful.
In the event that pelvic organ rupture has occurred because of the ectopic pregnancy, internal bleeding or hemorrhage may lead to shock. This is the first symptom of nearly 20% of ectopic pregnancies.
Shock is an emergency condition. Initial treatment may be keeping the woman warm, elevating her legs, and administering oxygen. Treatment with intravenous fluids and sometimes a blood transfusion is performed as soon as possible.
Surgical laparotomy is performed to stop the immediate loss of blood (in cases in which rupture has already occurred), or to confirm the diagnosis of ectopic pregnancy, remove the products of conception, and repair surrounding tissue damage. In some cases, removal of the involved fallopian tube may be necessary.
In non-emergency cases, mini-laparotomy or laparoscopy are the most common surgical treatments. Such procedures have similar outcomes. However, they are less invasive and are available at a lower cost because they require minimal hospitalization or outpatient treatment.
Non-surgical (medical) management for ectopic pregnancies without suspected immediate danger of rupture is being implemented in many medical centers . In such cases, methotrexate is administered with careful outpatient monitoring of the woman and serial quantitative HCGs, CBCs, and liver function tests.
Ectopic pregnancies cannot continue to term (birth), so removal of the developing cells is necessary to save the life of the mother.
About 85% of the women who have experienced one ectopic pregnancy are later able to achieve a normal pregnancy. A subsequent ectopic pregnancy may occur in 10 to 20% of cases. Some women fail to become pregnant again, while others become pregnant and spontaneously abort during the first trimester.
The maternal death rate from ectopic pregnancy in the U.S. has decreased in the last 30 years to less than 0.1%.
Rupture, with resulting hemorrhage leading to shock and the need for blood transfusion, is the most common complication. Death from rupture is rare.
Infertility occurs in 10 to 15% of women who have experienced an ectopic pregnancy.
A woman who has an early pregnancy, or who thinks she might be pregnant and has symptoms (especially lower abdominal pain or abnormal vaginal bleeding) should notify her health care provider. Ectopic pregnancy can occur in any woman who is fertile and sexually active, regardless of contraceptive use.


Builder~s Model Home Now Available for Sale. Possible Summer Delivery. Model Home is Loaded with High End Upgrades like Full Stone Front Exterior, Rear Composite Deck, Expanded Gourmet Kitchen, Upgraded Master Bath, Upgraded Stone Fire Place with Custom Built-ins, Upgraded Flooring and Electrical Options, and Side Car Entry Garage to name a few! The Sussex Series features 2935 sqft of living space and offers a main floor office/study and 2nd floor laundry, with 4 bedrooms and 2.5 Baths. The impressive Standard Features List includes but by no means is limited to First Floor Nine Foot Ceilings, Single Stage Crown on the Kitchen Cabinetry which Showcases a Variety of Rich Finishes, Granite Kitchen Countertop, Custom Crafted 5 1/2″ Baseboard & 3 1/4″ Door Trim, Foyer with Hardwood Flooring, Crown Molding in the Living Room and Dining Room, and a Family Room with Gas Fireplace! On the edges of West Norriton Township lies the remnants of what once was a much adored Swim & Tennis Club where locals from as far back as a half century can remember spending their summer days on this once fruitful farmland. DelGrippo Builders has charged themselves with the task of breathing fresh life back into the desolate ground with the construction of New Homes and once again bringing the happiness and laughter back to the rolling hills. With a new walking path to be strolled along and benches to sit upon, the serenity of Markley Pond will no longer be adorned by no trespassing signs. Instead 79 beautiful new homes amidst tree lined streets will surround the Pond and add to the beauty that is being created. Located just minutes from local shopping, dining, parks, golf courses, and the desirable Visitation BVM church and Elementary School. Easy access to major highways like Rts 422, 202, and the PA Turnpike for a quick trip to the King of Prussia Mall, Valley Forge Casino, The Philadelphia Premium Outlets and much more!
130 WORTHINGTON CIR #LOT 79 is a house for sale in West Norriton, PA 19403. This SQFT house sits on a 0.59 acre lot and features 4 bedrooms and 2 bathrooms. Built in 2017, this house has been on the market for a total of 2 years and is currently priced at $535,000.


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Longwood Reimagined will transform 17 acres of existing property and feature a 32,000 SF glasshouse at the heart of its renowned garden grounds.
CM w/ a GMP
Weiss/Manfredi and Reed Hilderbrand
Bancroft recently began construction on Longwood Reimainged, which will transform Longwood's Kennett Square property as it exists today. Adding new plantings and buildings across 17 acres, Longwood Reimagined: A New Garden Experience will expand the public spaces of the renowned central grounds and connect them from east to west, offering a newly unified but continually varied journey from lush formal gardens to views over the open meadows of Pennsylvania's Brandywine Valley.
In keeping with Longwood's tradition of blending fountain gardens and horticultural display, the centerpiece and largest single element of Longwood Reimagined is the creation of a new 32,000-square-foot glasshouse, designed by WEISS/MANFREDI, with gardens and pools designed by Reed Hilderbrand. This new West Conservatory with its asymmetrical, crystalline peaks seems to float on a pool of water, while the garden inside, inspired by the wild and cultivated landscapes of the Mediterranean, is conceived as seasonally changing islands set amid pools, canals, and low fountains.
In the tapestry-like garden design, iconic plants of this ecology such as aloes, laurels, blueblossom, and Greek horehound hug the ground, with higher plants such as cypress and 100-year-old olive trees rising up into the soaring space while other plantings are suspended from above. Building on the great 19th – century tradition of glasshouses through new sustainable technologies, the West Conservatory is a living, breathing building, with earth tubes and operable glass walls and roof that allow the interior garden to thrive.
For more information about Longwood Reimagined: A New Garden experience, please visit Longwood Reimagined | Longwood Gardens.
Longwood Main Fountain Garden Revitalization
After two years and over $90 million worth of construction, the Main Fountain Garden Revitalization, originally built during the 1920's stands as the largest fountain preservation project of its kind in the United States
Longwood Nursery Production Greenhouse
Longwood's newest greenhouse, the 80,948 SF facility, accounts for 60 percent of Longwood's crop production.
Longwood Meadow Garden Expansion
Spanning 86 acres, the Longwood Meadow Garden Expansion project added plantings, trails, bridges, and engaging interpretation to the three-mile site.
Nemours Reflecting Pool Restoration
Opened to the public in 1977, the Nemours Estate is home to the one-acre reflecting pool, which was restored to its original glory during this project.
Mt. Cuba Center Greenhouse/Headhouse
Part of a Master Plan project at a botanical garden, the Greenhouse Complex aspired to a zero-energy footprint and involved extensive environmental sustainability measures.


In AnTuTu test mobile phone Doogee F7 Pro got a score of 88000 points. This is due to the use of chipset MediaTek Helio X20 (MT6797) , having a main processor 2x 2.5 GHz ARM Cortex-A72, 4x 2.0 GHz ARM Cortex-A53, 4x 1.4 GHz ARM Cortex-A53 that using 64 bits architecture and graphic processor ARM Mali-T880 MP4. By opinion of China Prices mobile phone got a score of eight point three for hardware performance and overall score of five point seven AnTuTus.


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Suge Knight Claims Dr. Dre Paid $20,000 to Have Him Killed
Pool/Kevin Winter, Getty Images (2)
Even from behind bars, Suge Knight has been able to find ways to keep his name in the limelight. Now the former Death Row Records owner is making scandalous allegations about Dr. Dre, claiming the super producer tried to have him killed.
In new legal documents obtained by TMZ, Suge claims a man named Dwayne Johnson showed him a check for $20,000 that was signed by Dre back in July 2016. According to Suge, the payment was for the former record exec's life and Suge was supposed to be offed the day he ran over Terry Carter at the Straight Outta Compton set, killing him.
Suge claims Johnson was supposed to be in on the hit but flipped. He and Johnson later met with a private investigator. Suge says this is the reason he was scared for his life when he ran over Carter at the Tam's in Compton, a crime he is currently facing trial for. Dre's lawyers are refuting the claims.
Suge has been talking a lot while behind bars. Most recently, he claimed that Tupac Shakur might still be alive. "When I left that hospital, me and 'Pac was laughing and joking. So I don't see how somebody could turn from doing well to doing bad," he said during an interview for the new Fox series, Who Shot Biggie & Tupac. "I'ma tell you, with 'Pac, you never know," he added.
Earlier this year, he claimed he was the target of the deadly shooting that took the rap icon's life.
11 Rappers Who Were Shot While They Were in the Spotlight
Filed Under: Dr. Dre, Suge Knight


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Florida Medical and Dental Care
Duval Clinic Directory
Volunteers in Medicine-Jacksonville
Volunteers in Medicine-Jacksonville - Jacksonville Free Clinic
41 E Duval Street
Jacksonville FL, 32202
Clinic Details: Volunteers in Medicine Jacksonville, Inc. was established in 2002 by co-founders James Burt, MD and Dottie Dorion, RN, MS and opened its doors for patients in September 2003 — one of 94 Volunteers in Medicine clinics across the United States. All Volunteers in Medicine clinics are free clinics, but not all are dedicated to treating the working poor. The Jacksonville clinic is at the corner of Ocean St. and Duval St. in the old Paulus Music Store. The building was rehabilitated to a clinic shortly after incorporation through private donations and volunteer craftsmen. Ms. Dorion and Dr. Burt's reason for starting the clinic was that there were healthcare options for low or no income individuals that did not work, but no options for hardworking people who did not have access to medical care. The mission of Volunteers in Medicine Jacksonville is to provide free outpatient primary and specialty medical services to Northeast Florida's WORKING, low-income and uninsured individuals and families to keep them healthy, employed and out of our hospital emergency rooms. The Volunteers in Medicine Jacksonville Clinic is staffed by dedicated active and retired physicians, nurse practitioners, registered nurses, and specialists. These professionals dedicate their time to fulfill our mission of helping our community's working uninsured. Our success can be directly attributed to the passion and commitment of more than 230 active volunteer clinical and non-clinical professionals that perform a wide array of services at our downtown clinic five days a week.
Website: https://vim-jax.org/
Services: Health screenings for chronic diseases; Cancer screenings, Vision screening; Well woman exams; On site bloodwork for Lab test; Cardiology; Gastroenterolgy; Rheumatology; Dermatology; Gynecology; Urology; Endocrinology; Hematology/oncology; Dental
Dental Services: Cleanings
Remarks: Urban Area, Permanent Clinic, Year-Round, Part-Time (open 35 hours per week)
Payment Method: Free
Operation Hours: Tues-Fri: 9:00am-5:00pm; Sat: 9:00am-12:00pm
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Low Income Clinics Nearby
Sulzbacher Medical Center - Hope
Location: Jacksonville, FL - 32202 | 0.4 mile away
Details: A critical factor in the success of the Sulzbacher Clinics is the Sulzbacher Homeless Outreach Project Expansion (HOPE) medical outreach program. Started in 2000 in downtown Jacksonville, the HOPE initiative was expanded in 2008 to the beaches communities. The program utilizes trained medical outreach specialists to engage individuals who are living on the street. Clinical staff travels with the van to provide health and psychiatric services. The HOPE Team also distributes clothing, blankets, food, water, and basic hygiene items to the homeless. Transportation to the beaches clinic is provided for homeless persons that are unable to come to the clinic on their own.
Sulzbacher Medical Center - Downtown Clinic
Details: Our campus is home to the Sulzbacher Medical Center, a Federally Qualified Health Center and a Federal Tort Claims Act (FTCA) Deemed Facility that offers a complete range of health-care services to residents of the Sulzbacher Center and to others in need in our community. Each resident undergoes a comprehensive medical assessment and treatment for any health issues that are discovered. Community partners help in many areas, including providing free medication, medical case management, health-education classes, vision screenings, low-cost glasses, wheelchairs, and much more. The center benefits from the services of nurses, doctors, residents and interns from the University of Florida, Florida State University, Jacksonville University and the University of North Florida.
Florida Department Of Health In Duval County - Central Health Plaza
Location: Jacksonville, FL - 32206 | 1.1 miles away
Details: Our Mission: To protect, promote & improve the health of all people in Florida through integrated state, county & community efforts.
Uf Health Total Care Clinic - Jacksonville
Details: UF Health Jacksonville is the region's premier academic health center, a leader in the education of health professionals, a hub for clinical research and a unique provider of high-quality patient care. With more than 5,000 faculty and staff, the academic health center in Jacksonville is the largest UF campus outside of Gainesville. At 37 clinical sites throughout Northeast Florida, UF physicians tally more than 600,000 outpatient visits and more than 34,000 inpatient admissions annually.
Uf Health Community And Family Medicine - Jacksonville
Uf Health Women's Specialists - Jacksonville
Florida Department Of Health In Duval County - Happy Tooth Express And Smile Express
Details: The Florida Department of Health in Duval County Dental Program provides a school based dental care program. The two mobile dental units, Happy Tooth Express and Smile Express, visit elementary schools in Duval County providing services to Pre-K through 5th Grade students who are eligible for the Free and Reduced Lunch Program. The services provided to these students are dental examinations at least once a year, dental cleanings, fluoride treatments, oral hygiene instructions, and dental sealants as needed. The mobile units are staffed by licensed dentists.
Agape Community Health Center - Mobile Medical Bus
Location: Jacksonville, FL - 32204 | 2 miles away
Details: AGAPE Community Health Center, Inc. is a Federally Qualified Health Center (FQHC) committed to providing comprehensive medical, dental, pharmaceutical and behavioral health services for insured, uninsured, under-insured and medically under-served populations throughout the city of Jacksonville, Florida.
Uf Health Family Medicine - Brentwood
Uf Health Family Medicine - Elizabeth G. Means Center
©2021 Free Clinic Directory


Tracy is a graduate of Nelson County High School. She has been coaching and judging cheer since 2002. She is USASF Safety Certified, and judges for Varsity Brands and the Kentucky High School Athletic Association. Tracy is married to Jaime and they have a daughter named Kenley.
Ashton is a graduate of Nelson County High School. She has been coaching cheer since 2012. She is USASF Safety Certified. Ashton is married to Josh and they have a two year old son named Harrison.
Dexter comes to us from Georgia. Dexter is a former Gerogia All Star Cheerleader and former University of Louisville Cheerleader where he won a National Champsionship. Dexter has also been judging cheer for 5 years.


Continuing to chart my experience of Udacity's Android Developer Nanodegree we step up in level, embarking on the advanced part of the super-course.
Completing project "Popular Movies" (see Part 2 of this series) signaled the end of "Android Developer". Now we are ready to tackle the second element of the program "Advanced Android Developer", a new class with a new syllabus and project. Continuing to chart my experience of Udacity's Android Developer Nanodegree we step up in level, embarking on the advanced part of the super-course.
Completing project "Popular Movies" (see Part 2 of this series) signaled the end of "Android Developer". Now we are ready to tackle the second element of the program "Advanced Android Developer", a new class with a new syllabus and project.


Prolinx recently attended the Police ICT Summit 2018 at Hinckley, Leicestershire, demonstrating our policing capabilities on a Stand in the Suppliers Exhibition Hall and also sponsoring the drinks reception. The focus for the 2018 Summit was about demonstrating progress in delivering ICT reform across policing and its law enforcement partners, in line with the Policing Vision 2025.
The Summit looked to the future and demonstrated what a transformed service should look like and what contribution suppliers can make to aid this transformation. The event was well attended with senior representatives from a large number of the Police forces around the country, the Police ICT Company and the National Police Technology Council (NPTC).
This provided a unique opportunity for two-way conversations between suppliers and police forces, sharing best practice and exchanging innovative ideas that tied into the Summit key themes. There were updates from senior stakeholders in policing, across Government and industry on ICT Principles, Enabling Programmes, the Digital Policing Portfolio, Home Office Programmes, and more.


Part of serving the needs of campus is diversifying the nutritional profiles of our menus to accommodate a variety of needs and preferences. University Catering provides the following guide to help better inform our guests of our dining options. For weekly nutrition tips and information, visit our Nutrition at Notre Dame page on Facebook.
Look for the letter H which indicates a healthier option. The items with this marking are prepared using healthy techniques. They contain less fat or calories than other options and contain more vitamins, nutrients, and positive health influences. Include these as part of your balanced diet.
Look for the V to find vegetarian choices of entrees and soups. These items do not contain meat or fish. Vegetarian diets are one opportunity to benefit in both good health and social responsibility. Vegetables require much less natural resources to grow than animal products. If you are looking for Vegan choices, please visit the vegan page of our web site.
Because of new changes by the FDA with gluten free labeling, Campus Dining will no longer identify food items with a GF icon. However, we do offer menu items that do not contain wheat, rye, or barley as an ingredient. These items may have come into contact with gluten through regular production processes. We are not responsible for cross contamination or product substitution. If gluten must be strictly avoided, please contact our dietitian at ndfood@nd.edu to discuss options.


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Sub-tenants' Rights under the Commercial Tenancies Act (Ontario)
The ongoing uncertainty in the economy and the resultant market slowdown have tenants re-evaluating their space needs. After considering their options and weighing demand, some tenants determine that the appropriate way to shed space on a cost-effective basis is to sub-let all or a portion of it to a third-party sub-tenant. Often a condition of a sub-lease is the sub-tenant's waiver of its rights in case of termination of the head lease.
Preventing an Insecurity Complex: What to Do Before Your Landlord Goes Under
In economic downturns, talk in the commercial leasing industry inevitably turns to what to do with unreliable tenants and how best to protect the position of the landlord. However, it is not only landlords and sub-landlords that are facing problems; tenants and sub-tenants are increasingly finding themselves left out in the cold, figuratively and literally, when their landlord or sub-landlord faces financial difficulties.
Buying Time: Rent Relief Agreements
As a result of the current economic downturn, many commercial tenants are finding themselves in precarious financial positions and are approaching landlords to seek rent relief in order to survive until the economy recovers. While landlords are often hesitant to diminish their revenue stream by granting rent relief, they may have a strong self-interest in facilitating a successful lease restructure if the tenant's need is genuine.
Tenant Exit Strategies
Given the weak economy, many tenants may find themselves with premises that they no longer require or which they need to dispose of in order to cut costs. This update explores some of the more common exit strategies employed by tenants, each of which is fraught with business and legal issues.
Commercial Lease Gross-Ups
Commercial leases often contain gross-up provisions relating to the calculation of the tenant's share of operating costs and realty taxes. In addition, commercial leases often include gross-up provisions relating to the calculation of the tenant's rentable area. What are gross-up provisions? Why are they necessary and are they fair? What are the issues associated with gross-ups that landlords and tenants must consider?
Developers Beware: New Amendments to Financial Crime Legislation Apply
Key amendments to the regulations under the Proceeds of Crime (Money Laundering) and Terrorist Financing Act have now come into force. These amendments include real estate developers in the group of people required to keep records and report certain transactions. Most importantly, real estate developers will have to develop comprehensive compliance regimes specifically to manage this reporting.
Expropriation and Compensation - The British Columbia Framework
Governments must often invoke their powers of expropriation to carry out public projects. From an owner's perspective, if approached for a government land acquisition, there is always the reality that in the absence of a voluntary transfer, the owner faces expropriation of the required land in return for compensation.
Possession Following Mortgage Default and Environmental Liability
There are necessarily a number of business and legal implications which a lender must consider in determining whether to take possession of a mortgaged property. Foremost among these is the risk of incurring liability for costs in connection with the remediation or clean-up of any environmental contamination affecting the property and any related third-party claims.
Legal Implications of Possession in the Context of Mortgage Default
In Ontario, a lender's decision to take possession of a mortgaged property upon the borrower's default can have important implications. For example, once in possession of the mortgaged property, the lender incurs the obligations of a mortgagee in possession and is liable to account for the revenues that were or should have been received from the mortgaged property.
Selecting a Mortgage Enforcement Remedy
When a borrower defaults on its obligations under a mortgage in Ontario, the lender has a variety of remedies from which to choose. A lender's enforcement strategy and choice of remedy after a default has occurred will regularly depend on careful consideration and the weighing up of its options at as early a stage as possible. This update looks at the potential pitfalls that a lender may face along the path to recovery.
Landlord Waivers
Occasionally, a tenant will present a landlord with an agreement entitled 'landlord waiver' or 'landlord's waiver and consent', requesting often urgent execution. A landlord waiver is usually delivered to a landlord for execution in the context of a loan transaction by a tenant. As part of the financing, the tenant may be required to grant security over both its real and personal property in favour of its lender.
Green Building Designations: LEED versus BOMA Go Green
It seems these days that everyone is going green. The real estate sector is no different, with industry players rapidly familiarizing themselves with terms such as 'green leases' and 'greening a building'. This shift towards green building practices has been driven greatly by the benefits that are a direct result of implementing a green approach. But how exactly is a building designated as green?
Green Buildings and Green Leases: What's in it for Me?
The past several decades have seen a major push towards using environmentally friendly products, increasing conservation of resources and ensuring viable sustainability for future generations. Although progress has been slow, the green movement is becoming more prevalent in the commercial and industrial building and leasing sector of the economy.
How to Avoid Little-Noticed Traps in Sub-Leasing
Sub-leases are far from being a new concept in leasing, but recent cases have highlighted the subtle differences between a sub-lease and a standard commercial lease. Sub-landlords and sub-tenants should keep these thoughts in mind as they navigate the potential traps of sub-lease negotiations.
Commercial Leasing and Ontario's Limitations Regime
When changes were made to the limitations laws in Ontario in 2002, the legal community debated extensively about when and how the new limitations would apply to commencing an action in respect of existing and future disputes. Parts II and III of the former Limitations Act were repealed and replaced with the Limitations Act 2002.
Lender Non-disturbance Agreements - Pitfalls and Traps
Although there are several reasons why a tenant and mortgagee would want to terminate the lease if the mortgagee went into possession, tenants and mortgagees usually prefer to play it safe and obtain the protections afforded by a non-disturbance agreement. This update looks at some of the more significant issues to consider when negotiating non-disturbance agreements.
New Asbestos Regulation Affects Landlords and Tenants
New legal requirements regarding asbestos recently came into force, which significantly increase the responsibilities of landlords and tenants in dealing with asbestos in their buildings and premises. Lease negotiations will be affected by parties responding to the regulation.
Sale-Leaseback Transactions
Although not a new concept, there has been an increase in sale-leaseback transactions, both for owners of operating businesses that wish to monetize the real estate they use and for governmental agencies transferring the risk of management and ownership of government buildings to third parties. This update looks at the key differences between a sale-leaseback transaction and a normal leasing transaction.
Provisions to Watch for When Conducting Leasing Due Diligence
A purchaser of income-earning commercial real property must take steps to confirm the integrity and enforceability of the rental income stream. This update provides a brief explanation of nine key aspects of leases that should be reviewed by the purchaser or its legal advisers during the due diligence period.
Building Naming Rights as Part of a Lease Transaction
The granting of building naming rights is an inducement used by landlords to secure a desirable, major or lead tenant in a commercial development. For tenants, the ability to have their corporate moniker on a building is an important brand promotion tool. However, the issues associated with naming rights must be properly addressed as part of the lease negotiations.
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Find out more on what 'customer support' means in the web hosting community and about the different support varieties.
The customer support that you can receive from your shared hosting provider is very important, no matter if you have pre-sales questions and you are not a client yet, or you've got some technical problem with an active account. Prompt and correct info about a question or a problem will save you a lot of time and efforts, not mentioning that this is usually an indicator that you're ordering from a genuine website hosting supplier and not from a reseller. When you buy a hosting account via a company that doesn't own its servers and it can't access them right away, it is likely that you'll wait for a few days so as to receive a response to your query, which means that your websites may stay offline for a long time. Alternatively, a company which offers different means of communication and has a support staff that is available all the time will assist you to right away and help you limit or entirely avoid any kind of downtime and possible losses.
The customer and tech support services for our shared hosting packages are twenty-four-seven, therefore you can forget about waiting for several days so as to receive assistance. In case you aren't our client yet, you can call us, chat with a representative or send an e-mail. In case you do have an account, you can open a support ticket in addition to the other three options for communication. You can choose the most suitable way to contact us depending on what your location is or what device you are using. We're able to help you for almost any webhosting-related query that you may have or issue that you could encounter and even if you contact us during the weekend or on official holidays, we will be available 24/7. For more technical or time-consuming matters you can open a ticket, but even then the max response time will never exceed an hour.
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Herschel's Final Destination: The Moon?
Artist's impression of Herschel
Herschel will run out of its helium coolant at some point in the first half of 2013, after which the mission will be over. There is much debate about what to do with the spacecraft after that. One suggestion is to fly Herschel into the Moon, creating a fresh impact crater and allowing astronomers to search for further signs of water.
Once the helium coolant has run out, none of the the instruments on board will work, but the spacecraft itself will still be fully functional. There will be a few engineering tasks to complete, but after that the scientific mission of the spacecraft will be done. It won't be a complete derelict however: there will still be the on-board computers, the thrusters, the communications equipment, and the "Space Radiation Environment Monitor" – which measures high-energy particles coming from the Sun and other astrophysical phenomena.
Herschel has on board a number of thrusters, which it fires every month or so to keep it in its orbit around L2, a point in space 1.5 million km from Earth in the opposite direction to the Sun. The thrusters are not particularly powerful, but they are crucial – if the orbital maintenance manoeuvres weren't done, Herschel's orbit would become unstable and it would drift onto an unknown trajectory. While the risk is low, this unknown trajectory could cause it to return to the Earth in the future, possibly causing damage either on the ground or to orbiting satellites and spacecraft.
It's a problem that the European Space Agency are well aware of. Göran Pilbratt, Herschel's Project Scientist, told Spaceflight Now "When the coolant is gone, then Herschel is useless as an astronomical facility. The spacecraft needs to be put somewhere for posterity – you don't want it to come hitting our heads".
Herschel trajectory to its orbit around the L2 point, with the Earth, Sun and Moon also shown
The solution envisaged at the start of the mission was to fire Herschel's thrusters to place in a stable orbit around the Sun, which would remove the risk of it causing damage for at least a few hundred years. This would allow the spacecraft to be retrieved many years in the future, though some argue that it would be so out of date by then that. A research team, coordinated by Neil Bowles from Oxford University, has proposed a more permanent solution – to put Herschel on a collision course with the Moon.
This might sound more risky than the current plan, but in fact the spacecraft could be targeted at an area the size of a football stadium. Herschel's thrusters would not cause it to travel very quickly, and it would take severl months to reach the Moon. As it nears the Moon, the spacecraft would be accelerated by the pull of the Moon's gravity, and the 3-tonne spacecraft would impact at a speed of around 5500 mph. This would give it enough speed to excavate a crater 30 metres wide and 5 metres deep – large enough to be seen by spacecraft currently in orbit around the Moon.
The purpose of doing this would be to try to find water under the Moon's surface. The Moon used be thought to be a completely dry place. But parts of the lunar surface, particulary in deep craters near the Moon's poles, are never exposed to sunlight, and it is thought that water ice could be trapped beneath the surface, at depths up to a few metres. It's something that has be tried before, notably by NASA's LCROSS mission which crashed a rocket stage – which had a slightly lower mass than Herschel – into the crater Cabeus near the Lunar south pole. The trailing spacecraft took images of a plume of material that rose several miles high, and identified the presence of water – though only in this one location on the Moon.
The image of the impact of a rocket stage, taken by a trailing LCROSS spacecraft
The presence of water ice on the lunar surface could have an impact on future manned bases, not least because water can be used to generate fuel for rockets and spacecraft. Neil Bowles, a planetary scientist at Oxford University who is coordinating lunar impact proposal, pointed out that "It is certainly lower than the cost of a purpose built mission with similar science goals."
There are mixed reactions amongst the Herschel team. Some object on emotional grounds, while others are all for it. Matt Griffin, from Cardiff University and lead scientist of the SPIRE Instrument, commented that it's "better to go out in a blaze of glory and do some more science as we do so!"
The decision will be made by ESA in the coming months, but the research team are already picking possible locations. One question will still remain however: there's already a crater on the Moon called Herschel, so what will we call the new one?
Raed more: herschel.cf.ac.uk
Posted in ASTRONOMY, SPACE
Tagged with Herschel
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The Irish population haemorrhage: mapping 160 years of data
Posted on 5 August, 2011 by cassmob
Alerted by tweets from @IrishWattle @CaroleRiley and @QueenslandFHS, I investigated the link they'd provided for 160 years of Irish population data. The National Centre for Geocomputation's (NCG) Online Atlas Portal is an absolute goldmine for family historians with ancestry in Ireland. There are two options: mapping and data relating to 2002 together with a timeline chart for population changes across the decades, and the other relating specifically to the impact of the Famine comparing census data from 1841 to 1851. Both are invaluable tools for your background research.
Kilseily parish % population loss 1841 to 1851 from NCG website listed. Kilseily is in orange and the bar on the bottom right indicates it had a severe loss of people.
The population loss from Kilseily parish 1841-1851 from the NCG website listed.
Over the years I've read widely on the Famine, and crunched raw census numbers for my parishes of interest, primarily Kilseily and Killokennedy in East Clare. In my paper at Shamrock in the Bush 2009 I referred to the haemorrhaging of the people, a description which seems melodramatic but which is reaffirmed by the census data. Despite knowing the my ancestor's townland suffered a massive 47.24% loss of population between 1841 and 1851, seeing the long-term impact on the 2002 graphs is still heart-wrenching. In 2002, Kilseily had only just (by 14 people) regained the population it had in 1926, with a very long way to go to reach earlier population numbers.
When you're reviewing the maps etc, don't forget to use the "select indicator" button near the top left of the page as this lets you change the parameters which are being mapped to review such things as 1841 and 1851 population as well as the changes, acreage under potatoes and housing. For example it reveals that in 1841 Kilseily had 475 inhabited houses and 9 uninhabited. By 1851 there were only 258 inhabited houses and 13 uninhabited: the parish had lost 44% of its housing, presumably "thrown down" with the departure and death of the inhabitants.
It is easy to regard all this as simply mind-boggling numbers, but imagine for a minute you are in a large meeting hall with some 3000 odd people, many of whom are kin or close neighbours, people well known to you. Then in a magic-wand moment, every second person leaves the room, never to be seen again. Bewildered, you leave the meeting hall, only to discover that virtually every other building had also disappeared and the built landscape is changed forever. Your mind and emotions would be reeling I imagine. How the Irish who remained, and those who fled the country in desperation, ever coped with this sense of grievous loss is a mystery. My father had a saying which he repeated regularly over the years: "they left their country for their country's good". I confess I would mentally eye-roll and think it was not only melodramatic but irrelevant. It was only last night that it occurred to me that this sentiment may have been passed down as an historical "memory" of the need to leave Ireland because of the post-Famine impact on families: three of his great-grandparents left Ireland for Australia in the early 1850s.[i] In my mother's Irish ancestry, less can be found on their pre-Famine origins but these great-grandparents of hers also survived the Famine though they did not emigrate until the 1880s.
In my JSTOR reading yesterday I came across a journal article by Sharon O'Brien called "Remembering Skibbereen", based on her memoir " The Family Silver". Her belief is that these silenced memories of Famine deprivation, hunger, family loss, and the precariousness of housing and land, remain sub-consciously with descendants to this day, sometimes manifesting in depression or bewildering family behaviour patterns. If there is any validity to this hypothesis imagine the impact of this experience on Biddy Gollagher, Irish Famine Orphan, about whom I recently posted a story.
"Mapping the Great Irish Famine" is an excellent reference book.
I've rather diverted from abstract data into the human impact but it does highlight that these are not mere numbers we're looking at. If you are interested there is another brilliant source of information and mapping on the Famine which includes more wide-ranging data taken from the census. It is a book called "Mapping the Great Irish Famine"[ii] and is well worth buying or borrowing if you have an interest in these topics. This online article provides some background on it.
The census information for Ireland is also available online through the University of Southampton. It's a little more convoluted to get there than I remember it from previously as you need to search their library catalogue for, say, EPPI Ireland 1851 census and you will then select whichever county you're interested in. However as yet I've been unable to locate the raw data online that I had previously been able to download. Lucky I've saved Clare data already!
[i] Although his maternal line were Scottish, they didn't fare a great deal better in the difficult 1840s and 1850s though theirs was a fairly typical Scottish story of displacement from their home place to an urban environment prior to emigration. His German ancestry was more well-off but perhaps pushed out by the revolutions in Europe in the late 1840s as well as compulsory military service.
[ii] Authors: Liam Kennedy, Paul S Ell, E M Crawford and L A Clarkson. Published by Four Courts Press, Dublin in 1999.
Posted in Broadford, Cass family history, Family History, Gavin Family Queensland, Irish family history, O'Brien family, WiddupTagged EPPI, Irish census data, Irish famine, Killokennedy, Kilseily, Mapping the Great Irish Famine, Online Atlas Portal, Remembering Skibberreen, The Family Silver, The National Centre for Geocomputation, University of Southampton
JSTOR @ NLA: finding the historical context for family history
52 weeks of personal genealogy and history: Week 31: Grandparents' House: More charming than George Clooney?
6 thoughts on "The Irish population haemorrhage: mapping 160 years of data"
Jennifer Geraghty-Gorman says:
5 August, 2011 at 11:17 pm
An extraordinary find Pauleen! Also, Sharon O'Brien's thesis about about the sub-conscious inheritance, if you will, of the very real suffering of our Irish ancestors is absolutely fascinating. It would certainly go a long way in explaining many Irish 'habits', some of which I have witnessed in my own family, not the least of which is a sort of self-hatred. A wonderful post; thank you for sharing it.
7 August, 2011 at 9:12 pm
Thanks Jennifer. Yes I agree Sharon O'Brien's insights trigger off lots of reflections and "aha" moments…for me anyway. Cheers Pauleen
Thanks for the wonderful post! It's heart-wrenching to think about the reasons that some people crossed the oceans to reach new homelands. Your post makes me want to start researching the reasons why my ancestors may have left central Europe.
hi Sheryl, It is indeed heart wrenching. And yes, finding out the social circumstances at the times of our ancestors' emigration is so pivotal to our family stories. We may never know the precise reason but we'll have a good idea of the possible causes. Pauleen
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Q: OAuth - Python android app which can upload data to a server So I have a kivy app which asks the user some questions and then takes the responses and exports them to a .csv file.
Now, the functionality I want to implement is that the user of the app should be given a token from my server and then the app should be able to use that token to upload the .csv file to the server. When uploading, the server should be able to identify the user based on the token given to the app.
I have no idea on how to implement this using python. Can someone point me to tutorials or something that do something along those lines? I have a Linux/Debian server with just apache installed.

redpajama_set_name: RedPajamaStackExchange


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Malaysia Muslim Groups Call for Boycott of Cadbury, Kraft Foods
Members of Malaysian Muslim Wholesalers and Retailers Association (MAWAR), a non-governmental organization, throw Cadbury chocolate products into a dustbin as a protest and officially announced their boycott of Cadbury products, after their news conferenc
KUALA LUMPUR — Muslim retail and consumer groups in Malaysia on Thursday called for a boycott of products made by Britain-based confectioner Cadbury and its parent Kraft Foods Group Inc after two chocolate varieties were found to have infringed Islamic rules by containing pork DNA.
Cadbury Malaysia, a part of Mondelez International Inc. on Monday recalled the Dairy Milk chocolates after the finding by Malaysian authorities in a random test.
Products in the Muslim majority Southeast Asian nation are regularly checked to ensure they are halal, or permissible according to Islamic law.
Cadbury Malaysia only sells to the local market. Mondelez's Malaysia sales are a small fraction of the around 15 percent of its revenues that come from the Asia-Pacific region, but concerns over halal standards could jeopardize sales in bigger Muslim markets, such as Indonesia and the Middle East.
A Muslim retail group said on Thursday the 800 stores it represents would be asked to stop selling all products made by Cadbury and Kraft, which acquired Cadbury in 2010 in a $19 billion deal. Kraft subsequently spun off its North American grocery business as Kraft Foods Group.
Mondelez is the name of what remains of Kraft Foods Inc after the spin-off. Its brands include Oreo cookies and Ritz crackers, which were among more than a dozen products the Muslim groups urged Malaysians to boycott.
"This will teach all companies in Malaysia to maintain and protect the sensitivities of Malaysians," Sheik Abdul Kareem Khadaied, the head of research with the Muslim Consumers Association Malaysia, told a news conference in Kuala Lumpur.
He said the companies should have apologized and recalled all their products voluntarily.
"This is an issue that cuts across religion," he told Reuters. "It affects the vegetarians as much as it affects the Muslims."
Cadbury Malaysia said in a statement this week that it was working closely with the Islamic Affairs Department to ensure its products meet halal guidelines. It said the authorities were running more tests and would announce the results within a week.
A spokeswoman for Cadbury Malaysia declined to respond on Thursday to the call for a nationwide boycott.
The Muslim retail and consumer groups said a full boycott of Cadbury and other products was needed because the contamination was unlikely to have been limited to just the two types of chocolate.
"Although only two products were listed as contaminated, since the same mechanism is used to produce other products, doubt exists in our minds that all products could be exposed to the same contamination," said Bazeer Ahmad, an adviser with the Malaysian Muslim Wholesalers and Retailers Association.
Besides pork, items considered non-halal by Muslims include alcohol and the meat of animals and birds that have not been slaughtered according to Islamic rites.
More Asia News
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Hey friends, can we all agree to be super grateful that it's Friday? I know I sure am! I've rounded up some of my favorites of the week and, as always, be sure to share yours in the comments!
My first favorite is this Milani Bronzer in the shade Fake Tan. I love the contour because it's so cool toned and the bronze has just a bit of shimmer for a nice summer glow. Also, the pan is HUGE so it will last forever and because it's Milani it was affordable.
This second Milani product is not only aesthetically pleasing, but it also is really pretty as a blush topper. It's the illuminating face powder in the shade Amber Nectar. It's a bronze, blush, and highlight all in one but when you mix them all together you get the prettiest sheer coral. You can use it for a super natural blush or highlight and it's just gorgeous.
I've been doing more shop my stashes lately as I am trying super hard to rotate my ridiculously large makeup collection and I pulled out this beauty that I was obsessed with last summer. It's from an Etsy store called Give Me Glow and it's in the shade Halo, a super gorgeous golden highlight that packs a big punch. It was also really affordable.
I've also been loving using this e.l.f. contouring brush to get a majorly defined contour. It's super thin and dense so it really gets in the cheek to add definition and I am loving a bold contour lately.
Last but always most favorite is Stephanie, the blogger behind Go Fashion Deals. Not only do I love her blog for fashion inspiration, she also has an Etsy store (GeekyGlamSteph) now where she sells tee shirts like the one she's modeling above. I love them, especially paired with a skirt like she's showing here! Go check her out.
That illuminating face powder looks beautiful! You always find the BEST stuff, love checking out your suggestions. Hope you have the best weekend sweet friend, XO!
Oooh that first Milani is so pretty! I did not know that Stephanie had a Etsy store, too cool! I hope you have a blessed weekend sweet and beautiful friend!!
I love that bronzer! Milani has my heart especially when you can use cvs rewards on them. ;-) their shadows are amazing. Thank you so much for your kind words!!! It means a lot! Thank you!!!
I love the idea of "shopping your stash" regarding makeup. I've been trying to do that lately. Bronzer is one thing that I actually haven't worn for years and I don't currently own any, however these all look like good options!
Love all of these! Milani really is a great drugstore brand, I love so many of their products. Love the look of the elf brush too! Hope you're having a lovely week!


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Beverly Robertson (1827–1910) was a cavalry officer in the United States Army.

Beverly Robertson may also refer to:

Beverly Robertson (athlete) (born 1940), New Zealand long jumper and sprinter
Beverly Robertson (businesswoman) (born 1951), American businesswoman; see Greater Memphis Chamber

redpajama_set_name: RedPajamaWikipedia


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Ellen Falkner collects a medal at World Bowls Championships
Littleport bowler Ellen Falkner earns silver in women's fours at World Bowls Championships
Littleport bowler Ellen Falkner (Image: Danny Lawson/PA Wire)
Ellen Falkner had to settle for silver in the women's fours at the World Bowls Championships in New Zealand.
The Littleport player had skipped her England rink, which included Jamie-Lea Winch, Rebecca Wigfield and Wendy King, to the final in Christchurch without losing a match.
But they came up short in the decider, losing 23-8 to Australian quartet Kelsey Cottrell, Carla Krizanic, Rebecca van Asch and Natasha Scott.
Falkner's rink had an immediate mountain to climb after their opponents chalked up an eight-shot maximum in the first end.
The Australians carried on from their ruthless opening, extending their lead with singles or two-shot hauls.
They as good as killed the final off by scoring four shots in the 12th end and followed it up with another four, forcing the match to finish after 16 ends.
Falkner has the chance to gain another medal in the women's pairs with Sophie Tolchard with the group stage getting under way on Tuesday.


Ever wonder what might happen if you turned your garage into a distillery? Well, Slake is living that dream.
Our Grandad's beloved wood-work hideaway became SlakeHQ, the ultimate modern day man cave. From these humble beginnings, a journey connecting communities, science and nature began. Fighting every day to make the spirit world a little less boring, Slake brings you unique foraged flavours for the taste adventurers and spirit enthusiasts among us.
Our spirits are meticulously developed and produced by a doctor (no, not that type of doctor), this one's big into chemistry and nature, 'breaking good' from his Granddad's garage.
Slake is an independent distillery on the South Coast of England, situated in Shoreham-by-Sea between the South Downs National Park, the River Adur and the Sea; a beautiful part of West Sussex, which has a historically deep connection with nature. A short trip over the Downs brings us into the Weald, home to ancient Sussex woodland and unique natural heathland habitat. Inspired by the natural diversity of our locality and the fantastic ingredients we have around us we hand-craft quality spirits, distilled at the crossroads of science & nature.
His name is Slake and he's an insatiable Knucker – an infamous water serpent, said to be found across Sussex, residing in Knuckerholes & devouring unsuspecting sheep and farmhands alike. For us, dragons and mythological beasts represent the unknown, once marked on maps to warn wary travellers, they now hark back to times of adventure and discovery. In an interconnected and global world you could be forgiven for thinking that the time of exploration has passed us by, but the natural world still has many mysteries to divulge if we're willing to seek them out. Learning to live local and thrive with nature. This is our frontier.
We work with nature to thoughtfully hand-craft quality spirits that best capture the taste of the seasons and a sense of time and place. A passionate reflection of where & how they are made.
Everything takes place at SlakeHQ – from maceration to bottling, from development to distillation, batch by batch, we're hands on, completing the process from start to finish under one roof. Our nature led & exploratory approach certainly has its challenges, but we believe it is also the reason why our spirits are so unique. For us, it is not just the best way, but the only way. The yardstick we measure our success against is our customer, nothing gives us greater pleasure than hearing your feedback. But don't just take our word for it. Come & try something Slake for yourself! Search our events!
TIME TO SLAKE YOUR CURIOSITY?
STILL WANT TO GET TO KNOW US BETTER?
Hop over to the blog where you can read more about our journey as an independent artisan distillery, find out how and why our spirit's are made the way they are, share our tasty experiments (the triumphant and otherwise), and our vision for an ethical local business that works with nature.
Join our journey and receive the latest news, offers, articles and updates from Slake.


One is the coolest number when you reach for this single arm colorblock sweater. Cozy cotton knit and a flattering mock neck keep things clean and modern. Add just a touch of color this season and beyond to all your looks.


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Hillcrest Accelerates ZVS Inverter Technology Development for Use in Numerous Grid-Tied Applications
Hillcrest remains focused on deploying its inverter technology into a wide range of grid-tied applications
A grid-compatible ZVS inverter is expected to bring numerous benefits to V2X charging, renewable energy generation, energy storage and more
The company continues development of its Enhanced Powertrain Solution, the missing link between EVs and universal, bidirectional charging systems
VANCOUVER, BC, December 8, 2022 – Hillcrest Energy Technologies (CSE: HEAT) (OTCQB: HLRTF), a clean technology company developing transformative power conversion technologies and control system solutions for next-generation electrical systems, is pleased to announce that with the completion of Hillcrest's first Zero Voltage Switching (ZVS) inverter commercial prototype, the company is accelerating its development activities around grid-tied power conversion technologies.
The company is developing the firmware and hardware necessary to deploy its ZVS inverter technology into grid-tied applications, including renewable energy generation, storage, vehicle-to-everything (V2X) and EV charging infrastructure. This opens the door to accelerating progress on the company's grid-tied inverter, multi-level inverter and enhanced powertrain solution, all part of Hillcrest's building block approach to technology deployment. Completion and eventual commercialization of these Hillcrest grid-tied products is anticipated to create multiple future revenue streams for the company.
"Our ZVS inverter technology is intentionally designed to be decoupled from the power control system, making our firmware agnostic to specific applications, allowing us to move quickly to adapt our technology to any motor or grid application," said Chief Technology Officer Ari Berger. "With the completion of our 800-volt, 250-kilowatt traction inverter commercial prototype, we've set the foundation to facilitate our entry into grid-tied applications such as renewable energy generation and storage, as well as e-mobility charging."
The next generation of grid-tied energy systems will require high-frequency power electronics to better enable the smart, grid-forming capabilities of a more distributed, bidirectional system containing a variety of intermittent sources. Hillcrest's ZVS inverter technology is designed to provide new benefits to grid-connected energy systems by offering a more efficient and reliable means of deploying higher switching frequencies. The company's technology will also offer improved output power quality and control benefits not currently available in most electric power systems.
The new firmware and hardware being developed for Hillcrest's grid-focused inverters will also expedite advancements in the development of its patent pending Enhanced Powertrain Solution. This technology is a universal, bidirectional charging architecture that leverages the efficiency and high switching frequency capabilities of the company's ZVS inverter technology to simplify the overall powertrain and charging system. Hillcrest expects this technology to enhance an EVs efficiency, performance and capabilities beyond what is currently available through truly universal, bidirectional V2X charging.
The Enhanced Powertrain Solution is designed so that EVs would no longer require an onboard charger, which is expected to reduce the cost, complexity and weight of an EV powertrain. Onboard chargers are also responsible for charging losses of up to 14% and their removal from the system could result in immediate gains in charging efficiency, offering reduced charging times and costs to the end user.
Additionally, the Enhanced Powertrain Solution is intended to enable DC fast charging of 800V traction systems on existing 400V chargers without the need for an additional onboard DC/DC booster unit. Booster units are typically of a similar size and cost to the EVs traction inverter so eliminating the need for this unit as well as the onboard charger goes a long way in simplifying an EV and providing meaningful reductions in weight and cost.
As the future becomes increasingly electrified, Hillcrest Energy Technologies is reimagining how to manage energy on the grid, use it to charge vehicles and redeploy stored energy to stabilize systems through cutting-edge inverter and EV powertrain technology.
About Hillcrest Energy Technologies
Hillcrest Energy Technologies is a clean technology company developing high-value, high-performance power conversion technologies and digital control systems for next-generation powertrains and grid-connected renewable energy systems. From concept to commercialization, Hillcrest is investing in the development of energy solutions that will power a more sustainable and electrified future. Hillcrest is publicly traded on the CSE under the symbol "HEAT," on the OTCQB Venture Market as "HLRTF". For more information, please visit: https://hillcrestenergy.tech.
dcurrie@hillcrestenergy.tech
Walter Frank/Jennifer Belodeau
IMS Investor Relations
hillcrest@imsinvestorrelations.com


After you fill the jar, you set the candle holder inside the mouth of the jar. The top of the candle holder should be even with the top of the jar. You might have a little trial and error before you find just the right candle holder. Place the candle in the holder and then use the ribbon to tie a big bow around the neck of the jar. That's it! (You might want to use a little craft glue or your glue gun to tack the ribbon in place).
At Christmas you can purchase small ornaments and place them in the jar instead of the potpourri. Any small figurine would do–in the spring you could use little bunnies.
This entry was posted in Crafting Articles and tagged canning jar craft, easy homemade hostess craft on November 21, 2009 by admin.


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A working homemaker and an amateur blogger. My blog is a kaleidoscope where you can experience a colorful journey of life with a plethora of emotions. You can read stories from real life, nostalgic memoirs, emotions and feelings. Join me, and I take you on a memorable journey through my life. I promise you will be relaxed when you share your thoughts with me. I will make sure you return back a happy and contented visitor every time.