text:
What does Home mean?
Breaking Benjamin: Home Meaning
Get "Home" on MP3:
Get MP3 from Amazon
Home Lyrics
Play "Home"
I've got a little red bow
And I bought it for you
'Cause I know you're not fair
I don't get it, oh well
And you color my skin
And the colors don't blend
'Cause I'm gonna get you
And your little dog too
There's a yellow brick road
That we...
Oct 15th, 2009 10:14pm report
http://www.youtube.com/watch?v=zWaga-tSFG8
I'm sure Breaking Benjamin doesn't care how you interpret the song,but it seems to me that the song is about the Wizard of Oz; In this video he actually says "This song is about the 'Wizard of Oz'" .
Jan 8th, 2009 1:37pm report
This song is very much so aligned with the Wizard of Oz. The three times I've seen BB live they have introduced this song by shutting off all the lights on stage except for a single green strobe that they flash all over the crowd while a recording of the Wicked Witch states her famous line, "Ill get you, my pretty, and your little dog, too!"
There is no arguing for the song not having attachment to the classic film, but its highly likely that he is interpreting the movie to his own life. Maybe he had a childhood thing for Dorothy, maybe he is relating to a character. This is a freshman album, by all means, so quite possibly the song isnt the deepest of all their work to date, its still a great song and open to interpretation. We can take this as deep as we'd like, too.
Chulyin
Dec 19th, 2008 12:43pm report
The Wizard of Oz is a methapor.
This wabsire can explain it better than I can... Http://www.rumormillnews.com/cgi-bin/archive.cgi?noframes;read=115708
Anyway, seeing as how the Wizard of Oz is a metaphor (at least, the characters) I'd sayt that the song is a metaphor for a methaphor. It talks about going home, away from everything, and that could mean getting away from politics, government, etc.
But that's just my thought. It could be wrong. =)
Jul 4th, 2008 7:49pm report
THE WIZARD OF OZ IS A METAPHOR. life is a fucking metaphor. This song is about Wizard of Oz, therefore yes it is metaphorical.
Jan 18th, 2008 1:28pm report
(This refers to Dorothy)
(This refers to Ben's confusion of the story line, as he probably watched it as a small child)
(Refering to the black and white section's of the movie)
(A line courtasy of the Wicked Witch of the West)
That we follow back home
(Well that's a no-brainer)
'Cause I know you can't wait
Your belligerent hate
(This may be referring to the "Deeper Meaning" everyone seems to be talking about)
Like home
(Again, a line from Dorothy, another no-brainer there)
I've, got a southern belle too
And ruby red shoes
(Dorothy once again, from Kansas and her shoes)
With a body of straw
(Duh, the scarecrow)
Are you sick of it all?
(Refering to the twisted plot line of the movie)
There's a man made of tin
With an oil can grin
(The tin man)
And I'm gonna get you
(Wicked Witch of the West)
And I know you can't wait
There's a little white porch
And you wanted it so
(Refering to how much Dorothy wanted to go home during the course of the movie)
Can you let me go down
To the end of the road
(The Wizard of Oz)
In the black and the white
A technicolorful life
(This is refering to how boring the World seemed to Dorothy when she got home)
Can I stand by your side?
We can make it alright
'Cause I'm home
Then another arrived
It's a cowardly lion
What I want from this world
What I wanna resolve
When I want you to stay
So I wash you away
I don't wanna be bold
I don't wanna be cold
I don't wanna grow old
I don't wanna go home
(This is basically about how much Dorothy regrets going home in the end, as she finds the wirld boring compared to Oz)
Well that's my interpretation, I don't get why everyone seems to think that every one of thier songs has to have a deep meaning, the song is probably about a love that Ben had for this song as a child.
ilovepaparoach
Dec 3rd, 2007 12:56pm report
This song IS a fucking metaphor. Why would Breaking Benjamin write about the damn Wizard of Oz?! It makes no sense. This song is about the differences between himself and another person (probably a girl). He loves her but they just don't click together for her.
Dec 2nd, 2007 12:16pm report
The song does have a metaphor. It is surrounding the story of wizard of oz.
Oct 26th, 2007 10:30am report
Omfg not everything has to be a metaphor! they can write bout the freaking wizard of oz if they want. even the best artists can be random and not choose some deep song. quit tryin to change it into something it's not. It's wizard of oz. get over it
musica_equals_love
Oct 3rd, 2007 10:40pm report
It IS a metaphor, nobody as brilliant as Breaking Benjamin will write about a story. He doesn't know what he wants out of life (what I want from this world, what I want to resolve)
There is a girl, but he's confused about her. She makes his black and white life a technicolorful life. but the colors don't blend and she hates him. He wants to go home, which is back to how he was before her.
Sep 9th, 2007 9:31pm report
This song IS about the wizard of oz. Ben himself usually introduce "home" as "the song about the wizard of oz"
Aug 9th, 2007 8:33pm report
Its a metaphor for her being different and wanting different things than him, and she wants him to be something he's not but he loves her anyway and can't figure out what to do. There you go.
erinw88
Jun 7th, 2007 6:10am report
What? wtf?! I don't know what it's metaphorically, but it's not that, that makes absolutely no sense.
May 7th, 2007 5:16pm report
It's about him being in love but there are other people that are standing in his way of the girl. He is willing to give her everything, but isn't sure if the will is worth the reward.
Apr 29th, 2007 4:32am report
IT'S NOT ABOUT THE MOTHER FUCKING WIZARD OF OZ!!! It's a metaphor. I just don't know what the hell it means.
Apr 25th, 2007 4:17pm report
Not to mention "There's a yellow brick road that we follow back home" "I'm gonna get you and your little dog too" "There's no place like home" "Ruby Red Shoes" and "Black and the white, technicolorful life" Basically all about the wizard of oz.
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text:
Q: Issues while reading Writting USB data I am new to Linux operating system, i am trying to interface GSM module with USB,i interfaced USB with GSM module successfully, but i have problem while reading the data from GSM module, i can able to write data to GSM module but while reading its too difficult for me, some time i can able to read data but some time i can't able to read data, here i copy and pasted my code, please go through the code and please let me where i am failing to read data,
i need to write data normally to USB port and data should be read on interrupt based
USB configuration
int init_ttyusb0(int speed,int parity)
{
fd=open("/dev/ttyUSB1",O_RDWR|O_NDELAY|O_NOCTTY|O_APPEND,S_IRWXU|S_IRWXG|S_IRWXO);|O_NOCTTY|O_SYNC|O_NDELAY);
        perror("open");
        if(fd==-1)
        {
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        }

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        saio.sa_restorer=NULL;
        sigaction(SIGIO,&saio,NULL);

        fcntl(fd,F_SETFL,FNDELAY);
        fcntl(fd,F_SETOWN,getpid());

        tcgetattr(fd,&tty);
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        cfsetospeed(&tty,speed);
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        tty.c_cc[VTIME]=10;                       //0.5 seconds
        tty.c_iflag&=~(IXON|IXOFF|IXANY);
        tty.c_cflag|=CLOCAL;             // igniore modem controls
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        tty.c_cflag&=~(PARENB|PARODD);
        tty.c_cflag&=~CSTOPB;
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        tty.c_cflag&=~ISIG;      // Disabling interrupt signaling bits
//      tty.c_iflag&=~(IXON|IXOFF|IXANY); // Disabling software flow control
        tty.c_lflag&=~ECHO;
        tty.c_lflag&=~ECHOE;
        tty.c_lflag&=~ECHONL;
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        tty.c_oflag&=~OPOST;

        tcsetattr(fd,TCSANOW,&tty);
        perror("tcsetattr");
        printf("UART configured.....................\n");
}

Interrupt handler
-----------------------

void signal_handler_IO(int status)
{
        static int gsm_count
        read(fd,&zfc_buffer[gsm_count],sizeof(zfc_buffer));
        printf("%s\n",zfc_buffer);
        memset(zfc_buffer,0,sizeof(zfc_buffer));
        fcntl(fd,F_SETFL,!(O_ASYNC));

}

int main(void)
{
int init_ttyusb0(B9600,0)
 while(1)
        {

        printf("\n  eneter option > ");
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        buf[0]='A';
        buf[1]='T';
        buf[2]='\r';
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        write(fd,"AT\r",3);
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        usleep(150000);
        fcntl(fd,F_SETFL,O_ASYNC);// Enabling interrupt after write

        break;

}

redpajama_set_name: RedPajamaStackExchange


Once we take some time to look beyond the day to day necessities of language access it becomes apparent how diverse a society we live in.
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1 Response to "Impending Anniversary!"
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Monday – Friday, 9-11 a.m.
Scroll down for a contact form that you can fill out to sell your items or alert listeners to your yard sale, announcement, etc.
Think you've heard it all when it comes to buying and selling? If that's the case, you obviously have not listened to Home Ad on WSIC. Every weekday from 9-11 a.m., veteran broadcaster Pat Shannon takes to the airwaves to help listeners buy, sell, trade, find, or give away just about anything imaginable. From yard sales to lost dogs, and from appliances to electronics, there is not much you won't hear on Home Ad. Best of all, it is absolutely free to put an item on-air. Just use the information above to call-in, or e-mail your information to the show. Even traditional snail mail is accepted.
The Home Ad show has been a part of WSIC programming, though the name has changed, since the late 40′s. The Home Ad show evolved from a fifteen-minute afternoon segment to the two-hour talk program it is today. Home Ad is more than just a buy and sell program, though. Pat makes the show entertaining, funny, and uplifting so listeners will love to tune-in regardless of what they might have to put on-air!
Pat was born and raised in Iredell County, and first started working for Statesville Broadcasting in 1960 while at Troutman High School. After graduating from Troutman High School in 1961, and attending Mitchell College for a year, Pat joined the Air Force and was trained as a military broadcaster. With the exception of a year break in service, during which he returned to Statesville and WSIC from 1965-1966, Pat served 23 years of active duty in the Air Force with 16 years overseas in Armed Forces Radio and Television in Taiwan, Vietnam, Korea, Germany, Azores, Iran and Guam. While stationed stateside, Pat made training films for the Air Force and handled advertising and publicity for the Air Force Recruiting Service.
Please note that the Home Ad Facebook Page is a uniquely on-line community. Items posted there will not be read on-air.
Now, being semi-retired, Pat enjoys spending time with his wife, Sonja, and his two animal companions Scruffy and Mia. Pat also enjoys time spent on his boat "The Mulligan," and playing golf. He has two daughters, three grandchildren, and three great grandchildren. With the exception of trying to retire once, Pat has hosted the Home Ad show (and for a period of time, the morning show as well) since 1986.
Every Tuesday and Thursday Pat gives YOU the opportunity to WIN a Home Ad t-shirt!!!!!
The shirt displays a graphic of Pat Shannon behind the microphone on the front with his favorite phrase, "I'm blessed with the joy of living!" Frequent callers who have their own "Home Ad Handle" are listed on the back. A certificate of authenticity accompanies each Home Ad t-shirt, verifying that the shirt is indeed genuine. Be sure to tune-in Tuesday and Thursday mornings for a chance to win your own Home Ad T-Shirt! WSIC Contest Rules apply, CLICK HERE TO VIEW CONTEST RULES.
Home Ad is heard every weekday from 9-11 AM on 100.7 FM, 1400 AM, 1520 WDSL, and TV 21.2.
The HOME AD show is for individuals to buy, sell, and trade items of value. If you'd like to advertise your business, please call, 704-872-6345.
As always, we reserve the right to refuse, edit, and/or reject any and all submissions to the HOME AD Show. HOME AD is a pubic service of the station, and is for entertainment purposes. No warranties, endorsements and/or the like are expressed, implied, or suggested. The public is advised to take all precautions for safety if ever meeting anyone to purchase items. Always take friends and meet in very public places. The station is in no way responsible for transactions made after listening to Home Ad.


text:
The FA Launches Developing Creative Players Online Course
The FA is adding to its growing suite of free online coaching courses with the launch of its first ever Massive Open Online Course, or MOOC for short.
Developed in partnership with Birmingham University, this three-week qualification is titled "Youth Football Coaching: Developing Creative Players" and explores the developmental needs of young players as well as the role of the coach in coaching creative behaviour.
Available to all, the course will provide learners with three hours of innovative and engaging content each week where they'll have the ability to self-select or create the most appropriate teaching practices for young players' needs.
The course will also bridge unique gaps in policy, practice and research to provide a valuable learning experience.
Nick Baker, FA learning design and development manager, is one of the team behind the launch of the new course. He told TheFA.com that it's an exciting new step forward in the way The FA can deliver education to coaches around the country:
"In response to the changing needs of the modern learner, we're constantly looking at new ways of supporting coaches with new content in different formats.
"This MOOC is the first course we're developing in partnership with the University of Birmingham and we're really excited about its potential to offer a new way of supporting the development of grassroots coaches."
To join the course visit: https://www.futurelearn.com/courses/developing-creative-players-in-youth-football.
Barclays doubles investment in Women's and Girls' football
New three-year sponsorship deals agreed with Premier League and The FA to cover men's and…
Walking Football Tournament at The FDC
The FDC, Bowthorpe hosted The FDC Walking Football Xmas Cup 2021, this week.
Rainbow Laces: Di Cunningham
The theme of this year's Rainbow Laces campaign is 'Lace Up and Speak Up'.
Rainbow Laces: Tim Sadler
The theme of this year's Rainbow Laces campaign is 'Lace Up and Speak Up'.
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County 5IVES is returning
Norfolk's most popular small-sided football leagues are returning this April!
Supporting LGBT+ this February
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U18's semi-final fixture postponed
Futsal Fever!
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redpajama_set_name: RedPajamaCommonCrawl


Corps takes a new look at green bullet.
The Marine Corps intends to purchase 1.8 million rounds of the Army's new green bullet in addition to the millions of U.S. Special Operations Command cartridges already downrange as the service looks to find the best replacement for its Cold War-era ammo.
Source: Dan Lamothe and Matthew Cox for Military Times.


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It is compulsory for all international students studying in New Zealand to have medical insurance. Your school or institution may be able to help you purchase insurance. Sometimes, insurance costs will be part of your study fees.


The optics in play for Michigan coach Jim Harbaugh this season were plain to see. The Wolverines' battles to win a big games versus their rivals or play for a conference title have haunted him during his 4 seasons in Ann Arbor, despite the fact that three of those projects resulted in 10 wins.
Another offseason of concerns about the direction of the Michigan program and Harbaugh's capability to provide it that last push back to college football's top tier make sure to come after the Wolverines' 41– 15 loss to Florida in the Chick-fil-A Peach Bowl.
Michigan played without four essential starters, consisting of defensive end Rashan Gary and linebacker Devin Bush, who both declared for the NFL draft and are anticipated to go in the very first round. Leading rusher Karan Higdon also skipped the championship game to get ready for his pro profession.
In spite of a blowout 62– 39 loss to Ohio State in the routine season ending, the Wolverines still got in the video game ranked No. 1 in backyards enabled and 2nd in pass defense, providing up 17.6 points a game. However that stout defense was exposed time and time once again with the crafty playcalling of Gators coach Dan Mullen, who established his receivers to facilitate catches, unleashed quarterback Feleipe Franks' running capability and, rather of attempting to face the middle of Michigan's defense, called up jet sweeps and option plays at the best times.
Michigan, who lost to Florida for the very first time in 5 meetings in between the 2 schools, got the game's first goal on a Donovan Peoples-Jones nine-yard catch from Shea Patterson. The Wolverines' junior quarterback was largely inadequate after that, finishing 22-of-36 for 236 yards with one touchdown. He was picked off twice by Chauncey Gardner-Johnson, who took his second interception to your home to cap the scoring, and was sacked 5 times.
Michigan's unique teams did its part, providing a trigger in the 2nd quarter when J'Marick Woods got his hands on a Florida punt, however the Wolverines had to opt for a 48-yard Jake Moody basket after acquiring no yards on the occurring belongings. The Wolverines obstructed a 2nd punt that went through the back of the end zone for a safety, but their ensuing ownership ended with Gardner-Johnson's exclamation point pick-six, setting off a celebration on the Florida sideline.
The Gators waited patiently for their chances and lastly took the lead for great before halftime thanks to the legs of Franks. On a 75-yard march to a three-point halftime lead, Franks had runs of 30 and 15 lawns prior to striking paydirt on a 20-yard scuttle. Franks tossed for 174 yards and added 74 on the ground with 2 overall goals, ending his roller-coaster year on a high note.
35– 31 win. That game started a rare offending hot streak, in which the Gators gained 500-plus yards in each of their final three regular season games after reaching that threshold just once before November. Florida acquired 427 lawns on Saturday, converting eight of their 16 third-down chances and scoring on each of their 5 red-zone belongings at the expense of planner Don Brown's vaunted defense.
Michigan's meltdown was complete when Lamical Perine raced unblemished for 53 backyards on a third-and-20 draw to put Florida put by 3 goals. The Wolverines quit a season-high 257 yards on the ground to Gators.
As Michigan and its fan base fume over this most current addition to Harbaugh's 1– 3 bowl record, the Wolverines will be losing some crucial factors. Still, 2019 figures to establish well for another run at conference and national hardward, with the news that Patterson is going back to school for his senior season.
Florida will look to continue to develop itself into a challenger to SEC East champ Georgia, with the hope of being back in Atlanta for the SEC title video game and beyond. For now, the Gators have a humiliation of among the nation's most appreciated defenses as a springboard into the offseason.


The Birds is now taking bookings for your festive feasts.
Has your annual Christmas party become predictable? Instead of going through the motions when it comes to planning your Christmas party, you could opt for something unique; something that gets guests excited; something they'll be talking fondly about over the next 12 months.
The Birds takes influence from the great Alfred Hitchcock, creating an exciting and unique venue to host your parties and lasting festive memories.
Beers & Booze: The Birds will always have the latest and most interesting craft beers as well as a tasty wine list to compliment your feast. Give us a buzz to find out what we have on the taps!


The Brooklyn-based duo Medium Mystic – comprised of Brenna Ehrlich and Morgan Enos – began their collaboration writing songs together despite living on opposite coasts – Morgan in California and Brenna in Brooklyn. Their quirky subject matter included dreams, night terrors, and their mourning of the loss of David Bowie. "Sleepwalk Girl" is about that very topic, and it comes to fruition now that they both reside in Brooklyn.
With raw instrumentals and upbeat vocals, "Sleepwalk Girl" possesses otherworldly elements, and is widely comprised of a very 60's musical vibe, much like The Animals' "It's My Life".
Medium Mystic will be playing their first show on December 7th at Shea Stadium. It is a benefit for Planned Parenthood. Tickets are available here.


text:
MRG puede referirse a:

Política y sociedad
 Grupo de Investigación de las Minorías (), primera organización británica para la defensa de las lesbianas, activa entre 1963 y 1972;
 Movimiento de los Radicales de Izquierda (), denominación anterior del Partido Radical de Izquierda, un partido político francés;
 Movimiento de Resistencia Global, red de colectivos alterglobalización surgido en la antesala de las protestas de Praga en el año 2000.

Otros
 Magnetorresistencia gigante (MRG en sus iniciales en español, GMR en inglés), efecto mecánico cuántico que se observa en estructuras de película delgada compuestas de capas alternadas ferromagnéticas y no magnéticas.

redpajama_set_name: RedPajamaWikipedia


A 1999 graduate of Oakes College, Kenji Treanor earned his B.A. in American Studies with an emphasis in ethnic studies and socio-political analysis. Kenji has continued his social justice work through his professional as well as volunteer activities.
Stephanie Casher graduated from UC Santa Cruz in 1998 with a Bachelor's degree in Sociology and a minor in Education. After graduation, she became a staff member on campus, and now with eleven years of service under her belt, currently works as a Committee Analyst in the Academic Senate. Stephanie nurtures her creative spirit and passion for the written word by moonlighting as a writer and freelance editor. In December 2009, Stephanie partnered with two fellow writers to start their own publishing company, The Pantheon Collective (TPC), LLC.
Marti Noxon graduated from Oakes College in 1987 with a B.A. in Theater Arts. Marti has written and executive produced for many critically acclaimed shows including Buffy the Vampire Slayer, Grey's Anatomy, Private Practice and Still Life. She is readying her launch into the film arena with the release of Dreamworks/Disney's I Am Number Four.
David graduated from Oakes College in 1989 with a degree in Biology. He went on to receive a Doctorate in Veterinary Medicine from UC Davis in 1993. David returned to Santa Cruz after veterinary school. In 1999, he converted an abandoned house on Laurel Street into the Westside Animal Hospital. He has a thriving Veterinary practice and continues to be actively involved in numerous community organizations.
Teri Greeves uses the traditional skill of beadworking to tell stories in innovative ways and create a new language that draws people together.
As an amazing Oakes and campus leader, Shadin is dedicated to mentoring students, both informally and as a Neighborhood Assistant. She has also been an active member of Rainbow Theater, and helped to coordinate the Afrikan Black Coalition Conference on our campus. This was the first time Afrikan Black Coalition Conference was hosted on our campus in 10 years; Shadin's leadership was essential in making this happen. While doing all of this, Shadin earned a 4.0 during the Spring 2014 quarter.
Hanes's interest in the topic of sports related head injuries and her gel-helmet proposal earned her two visits to the White House this week as a part of the administration-sponsored science fair along with an opportunity to talk with President Obama.
Don Rothman joined the Oakes College (then College Seven) faculty in 1973, hired to teach writing and coordinate the writing tutoring program. After 34 years of teaching, Don "retired". He dedicated his work to exploring the promise of writing to enhance democracy, especially in the area of non-violent persuasion. He has recently published a book that combines some of his writings as well as his other love, photography.


Great opportunity to own on LBI. Recently remodeled condo, some features include a new kitchen, new floors with updated baths. This 2 bedroom 1.5 bath condo (with a POOL!) is situated in the heart of Barnegat Light with in walking distance to the beach and local attractions.


text:
"""Defines test utilties useful for testing BYOC flows."""

from tvm import relay
from tvm.relay.expr_functor import ExprMutator
from tvm.relay.op.annotation import compiler_begin, compiler_end

class CcompilerAnnotator(ExprMutator):
    """
    This is used to create external functions for ccompiler.
    A simple annotator that creates the following program:
           |
      -- begin --
           |
          add
           |
        subtract
           |
        multiply
           |
       -- end --
           |
    """

    def __init__(self):
        super(CcompilerAnnotator, self).__init__()
        self.in_compiler = 0

    def visit_call(self, call):
        if call.op.name == "add":  # Annotate begin at args
            if self.in_compiler == 1:
                lhs = compiler_begin(super().visit(call.args[0]), "ccompiler")
                rhs = compiler_begin(super().visit(call.args[1]), "ccompiler")
                op = relay.add(lhs, rhs)
                self.in_compiler = 2
                return op
        elif call.op.name == "subtract":
            if self.in_compiler == 1:
                lhs = super().visit(call.args[0])
                rhs = super().visit(call.args[1])
                if isinstance(lhs, relay.expr.Var):
                    lhs = compiler_begin(lhs, "ccompiler")
                if isinstance(rhs, relay.expr.Var):
                    rhs = compiler_begin(rhs, "ccompiler")
                return relay.subtract(lhs, rhs)
        elif call.op.name == "multiply":  # Annotate end at output
            self.in_compiler = 1
            lhs = super().visit(call.args[0])
            rhs = super().visit(call.args[1])
            if isinstance(lhs, relay.expr.Var):
                lhs = compiler_begin(lhs, "ccompiler")
            if isinstance(rhs, relay.expr.Var):
                rhs = compiler_begin(rhs, "ccompiler")
            op = relay.multiply(lhs, rhs)
            if self.in_compiler == 2:
                op = compiler_end(op, "ccompiler")
            self.in_compiler = 0
            return op
        return super().visit_call(call)

redpajama_set_name: RedPajamaGithub


We're very excited to announce that CR Languages will be at to a new location starting January 22nd, 2019. Our new address will be 1655 W. Fairview Ave, Ste. 117, Boise, ID 83702.
This move is indeed unexpected, even for us! However this new space has some significant advantages, and we had to move quickly to make it happen. It will allow us more room to grow and more comfortable class sizes for our growing group and children's classes. It also offers better sound control, and …… drum roll, please…… FREE PARKING FOR EVERYONE!!! We'll still be close to downtown and all that it has to offer, as well as the connector.
We will be operating out of the old office until Friday, Jan. 18th. We greatly appreciate your flexibility and understanding as we make this move.


The timed-sequential chemotherapy regimen consisting of etoposide, mitoxantrone and cytarabine (EMA) is an effective therapy for relapsed or refractory acute myelogenous leukemia (AML). We postulated that granulocyte colony-stimulating factor (G-CSF) might enhance the cytotoxicity of EMA by increasing the proportion of leukemic blasts in S-phase. We added G-CSF to EMA (EMA-G) for therapy of advanced high-risk AML patients.
High-risk AML was defined as refractory, relapsed or secondary to either an antecedent hematologic disorder or exposure to cytotoxic agents. The patients were treated with one course of EMA-G consisting of mitoxantrone and cytarabine on days 1–3, and etoposide and cytarabine on days 8–10. G-CSF was started on day 4 and continued until absolute neutrophil count recovered.
Thirty patients were enrolled. The median age was 51 years (range, 25–75). Seventeen (61%) patients had unfavorable cytogenetic karyotypes. Twenty (69%) patients had secondary AML. Ten (34%) had relapsed disease. Four (14%) had refractory AML. Three (10%) patients died from febrile neutropenia and sepsis. Major non-hematologic toxicity included hyperbilirubimenia, renal insufficiency, mucositis, diarrhea, nausea and vomiting, skin rash. A complete remission was achieved in 13 (46%) patients. Median overall survival was 9 months (range, 0.5–66). Median relapse-free survival (RFS) for those who had a CR was 3 months (range, 0.5–63) with RFS censored at the time of allogeneic bone marrow transplantation or peripheral stem cell transplantation for 6 of the patients.
EMA-G is a safe and efficacious option for induction chemotherapy in advanced, high-risk AML patients. The activity of EMA may be increased if applied in patients with less advanced disease.
The combination of timed sequential chemotherapy and hematopoietic growth factors allows for an initial cytoreductive course of chemotherapy before starting growth factors. The growth factor could then work with the other "humoral factors" generated by chemotherapy to maximize recruitment of leukemic blasts into cell cycle. Few studies have tested this approach. We report the results of a clinical trial assessing the potential benefit of adding G-CSF to a proven timed sequential chemotherapeutic regimen.
All patients had AML defined according to the standard French-American-British (FAB) cytologic and cytochemical criteria . Patients were considered to have good-risk cytogenetics if their karyotype revealed either t(8;21), inv(16), t(16;16) or t(15:17). A normal karyotype defined intermediate-risk cytogenetics. All other clonal abnormalities were considered poor-risk. Patients were eligible for this protocol if their leukemia was: 1) refractory to previous induction chemotherapy, 2) in first or subsequent relapse after initial complete remission following induction chemotherapy, 3) secondary to transformation from an antecedent hematologic disorder, or 4) secondary to previous exposure to cytotoxic agents. All patients were over 18 years of age. Only patients with a performance status of 2 or less and no organ failure [less than grade 2 according to the World Health Organization (WHO) grading system] could enter the study, except if organ failure was related to the leukemia itself. Patients with leukemic meningitis were excluded. All patients gave signed informed consent and were treated on clinical protocols approved by the Cleveland Clinic Foundation's Institutional Review Board.
The EMA regimen contains etoposide, mitoxantrone and cytarabine administered in a timed-sequential fashion.  We added G-CSF to the EMA regimen, thus EMA-G. EMA-G consists of mitoxantrone 12 mg/m2 per day intravenous (IV) bolus for 3 days (day 1 to 3) with cytarabine 500 mg/m2 per day IV continuous infusion (CI) for 72 hours (day 1 to 3). Etoposide 200 mg/m2 per day IVCI for 72 hours and cytarabine 500 mg/m2 per day IVCI for 72 hours were administered on day 8 to 10. G-CSF 5 mg/kg per day subcutaneouly was started on day 4 and continued until the absolute neutrophil count (ANC) rose above 0.5 × 109/L for two consecutive days (Fig. 1). Only one course of EMA-G induction was given. Post remission therapy included chemotherapy, allogeneic bone marrow transplantation (BMT) or peripheral stem cell transplantation (PSCT) at the treating physician's discretion and availability of a transplant donor.
All patients were cared for in semi-private rooms supplied with HEPA filters on a regular oncology unit. All patients received standard supportive care including blood component support for severe cytopenias as previously described. Acyclovir 250 mg/m2 per day IV or 400–800 mg PO bid, allopurinol 300 mg PO qd and fluconazole 400 mg PO qd were administered prophylactically.
Bone marrow aspirates and biopsies were obtained on day 8 of chemotherapy and then at the discretion of the treating physicians. When a bone marrow aspirate or biopsy obtained on or after Day 14 contained 5% or more blast cells, G-CSF was stopped.
Complete remission (CR) was achieved when the following parameters were met: 1) bone marrow was normocellular, containing <5% blasts, >15% erythroid cells, and >25% normal granulocytes; 2) peripheral blood had neutrophils > 1.5 × 109/L, hemoglobin >11 gm/dl, and platelets > 1 × 1011/L; 3) no evidence of extramedullary leukemia, and 4) all of the above fulfilled for at least 4 weeks. Nonresponse to EMA-G induction was defined as the absence of CR after one course of induction therapy. Relapse was defined by the appearance of circulating blasts or bone marrow blasts >5% in a patient previously in complete remission.
The method of Kaplan and Meier was used to analyze overall survival, relapse-free survival, time to neutrophil recovery and time to platelet recovery. Exact 95% confidence intervals (CI) based on the binomial distribution were calculated for proportions such as the complete response rate.
From August 1994 to November 1996, 30 patients were enrolled onto this study. One patient received high-dose cytarabine instead of EMA-G for induction therapy after enrollment and was therefore excluded from further analysis. Thus, 29 patients received EMA-G induction therapy and are evaluable for treatment-related toxicity. Only 28 patients are evaluable for induction response since 1 patient was lost to follow-up shortly after receiving induction therapy (no evidence of persisting leukemia by the post-induction bone marrow biopsy). The characteristics of the evaluable patients are listed in Table 1. Twenty-eight patients had cytogenetic studies of bone marrow aspirates. Most patients (61%) had unfavorable karyotypes. The majority of patients (69%) had secondary AML transformed from either MDS (n = 10), CML (n = 5) or other myeloproliferative diseases (n = 4), or secondary to cytotoxic agents (n = 1). Overall, 15 patients with secondary, but untreated, AML were enrolled. Four patients were enrolled with AML refractory to previous induction therapy, and 10 were enrolled with relapsed AML.
Characteristics of 29 patients with AML treated with EMA-G.
The median time from the start of chemotherapy to recovery of an absolute neutrophil count exceeding 0.5 × 109/L was 30 days (range, 19 to 47 days). Three patients died of febrile neutropenia and sepsis during induction therapy. The median duration of platelet transfusion dependence was 30 days (range, 22 to 48 days).
Twenty-eight patients are evaluable for treatment response. Thirteen patients (46%, 95% CI 27%–66%) achieved a complete remission. Seven of those 13 patients with CR had secondary leukemia. Twelve patients (43%) failed to achieve CR following induction treatment. One of the non-responders had no evidence of leukemia after induction treatment and proceeded to bone marrow transplant before meeting all of the criteria for complete remission. Three patients (10%) died during induction treatment.
Of the 13 patients who achieved CR, 6 patients received further consolidation chemotherapy (3 with high dose cytarabine, and 3 with intermediate dose cytarabine combined with daunorubicin, etoposide, or interleukin-2), and 6 patients received either allogeneic BMT or allogeneic PSCT. One patient relapsed before any post-remission therapy was given. Of the 13 patients who did not achieve CR, 1 received salvage chemotherapy, 2 received allogeneic BMT, and 10 died due to rapid disease progression.
The median overall survival (OS) for all evaluable patients is 9 months (range, 0.5–66 months). Median relapse free survival (RFS) for those who achieved CR is 3 months (range, 0.5–63 months) with 6 patients censored at allogeneic BMT or PSCT. At five-years of follow-up, 3 patients (11%) were still alive. Two of them were in CR, one of whom had allogeneic BMT and the other had high dose cytarabine as post-remission therapy. The third patient is alive with recurrent leukemia.
All patients experienced fever in the setting of severe neutropenia. Fifteen (15%) patients had documented infections. Three patients (10%) died from febrile neutropenia and sepsis. Other WHO grades III-IV toxicity included mucositis (17%), diarrhea (17%), skin rash (14%), nausea and vomiting (14%), bleeding (3%). Ten (34%) patients had reversible hyperbilirubinemia and 5 (17%) had WHO grades III-IV renal insufficiency. Three (10%) patients experienced severe neurological toxicity (1 with seizure, 2 with severe vertigo) but those complications resolved shortly after the completion of induction therapy. GCSF was stopped in 1 patient due to persisting peripheral blasts. When G-CSF was discontinued the peripheral blasts cleared and the patient achieved a complete remission.
Rather than use a standard high-dose cytarabine regimen we employed the EMA chemotherapy protocol devised by Archimbaud and colleagues.  This regimen is effective in patients with relapsed and refractory AML with a reported CR rate of 60%. In addition EMA avoids the cerebellar neurotoxicity of high-dose cytarabine. Recognizing the potential value of hematopoietic growth factors, Archimbaud and colleagues added GM-CSF to the EMA regimen beginning on Day 4 of treatment. Unlike the current report, however, GM-CSF was discontinued on Day 10 of treatment. Unfortunately the addition of GM-CSF did not increase the CR rate when it was compared to placebo in a prospective randomized study in patients with relapsed and refractory AML.  The results with EMA and EMA plus GM-CSF are compared with our own results in Table 2.
Comparison of three clinical trials of EMA with and without the use of hematopoietic growth factors.
The treatment of advanced high-risk AML patients remains challenging. The use of EMA-G in the current study failed to demonstrate a better CR rate than published data of EMA alone or EMA with GM-CSF (EMA-GM). However, the 46% CR rate achieved in our cohort of patients with a higher proportion of secondary AML and older median age suggests that the EMA-G regimen deserves further study in a population of patients with less advanced disease.
X-YH collected and compiled the data and reviewed the manuscript with MK. PE participated in the design of the study, performed the statistical analysis and wrote the statistical section. MH, AL, BP, and SA conducted the study, contributed patients, and commented on the data analysis and manuscript. MK conceived of the study, reviewed the data collection and analytical processes, and wrote the body of the manuscript. All authors read and approved the final manuscript.
acute myelogenous leukemia. G-CSF, granulocyte colony-stimulating Factor. GM-CSF, granulocyte-macrophage colony-stimulating Factor. EMA, etoposide, mitoxantrone and cytarabine. EMA-G, EMA and G-CSF.
We thank the nurses and staff of H71 without whose aid we could not perfom our work.


WooThemes, the parent company or designer that mooted the concept of WooCommerce, hired developers James Koster and Mike Jolley who established the ecommerce plug-in. The plug-in ended up being a phenomenon overnight and in 3 years there were practically half a million sites utilizing the plug-in, which offered it a market share of simply short of 20% of all ecommerce sites. By the end of 2015, WooCommerce had been actively installed by millions of users and it was powering around 30% of the ecommerce market. While WooCommerce has remained among the totally free themes and plug-ins of WooThemes, there are thousands of extensions and add-ons, a number of which are premium and hence have to be spent for.
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text:
Reminder: Most People Endangered by Football Don't Play in the NFL
President Obama says it's OK to enjoy events like the Super Bowl because the players are consenting adults. But most of the country's players are kids and teens who don't know better.
By Gregg Easterbrook
A youth participates in a December NFL game's halftime program. (Chris Schneider / AP)
On Sunday evening, the 48th Super Bowl will kick off, and millions of Americans will tune in—the Super Bowl has been the most-watched television broadcast for 20 of the last 20 years. Americans need not view the controlled violence of the professional football as a guilty pleasure: The president says it's okay to watch NFL games.
"These guys, they know what they're doing. They know what they are buying into," in terms of risk, the president told David Remnick of The New Yorker.
Obama is correct—there is no reason not to enjoy the Super Bowl. I'll be at the game, and anticipate having a great time. I like Seattle by a field goal.
But Remnick and Obama spoke only of the NFL. Most attention to football focuses on its professional level, where "they know what they're doing" is a common theme. For instance, a few days after the president's remarks were published, Mike Florio, a football analyst for NBC, denounced "incessant hand wringing" about football's neurological harm—the players are highly paid "grown men."
Can Youth Football Be Saved? (And Should It Be?)
An Electrifying Adaptation of a Murakami Short Story
15 Books You Won't Regret Re-reading
Bethanne Patrick
Focusing on the grown men of the NFL is the wrong way to think about this sport's impact on society. Ninety-eight percent of football players are tykes, tweens, and teens who, legally, are children; who assume all the risks for none of the gain; who emphatically do not "know what they are buying into."
In The New Yorker interview, Obama compared football to prizefighting, a sport of which Remnick has written admiringly. In reference to adults who play in the NFL despite knowing its dangers, the president added, "It's sort of the feeling I have about smokers, you know?"
By this logic, children should be allowed to smoke. Eight-year-olds should be able to smoke, since they play full-pads tackle in many leagues. Middle schools should sponsor cigarette clubs. High schools should get the student body together for smokers' pep rallies.
Or if boxing is the correct analogy, it's as if every high school had 100 boys in a prizefighting society that stages a dozen public battles-royal each fall in front of the entire school. It's as if public universities spent more on the boxing program than the English Department. (Ohio State football budget for 85 players: $23 million. Ohio State writing center budget for 43,000 undergraduates: $800,000.) It's as if large public universities spent $13,736 on academics per student and $138,424 per member of the boxing team—the actual latest numbers for education versus football. (Check this tool created by the Knight Commission on Intercollegiate Athletics, which is the good twin to the NCAA's evil twin.)
Pro football is the No. 1 sport of the No. 1 nation, so it's only natural the NFL is the focal point when football is mentioned. It's fine to love this fabulous game. I played in high school and college, have attended way too many NFL contests including many Super Bowls, and look forward to attending more. I wince whenever an NFL player is injured, though understand that risk is part of producing great athletics—just as dancers may ruin their knees or lower backs in producing great ballet.
At the high-school level, too many programs operate like cults, pulling teens away from the classroom while instilling a sense of BMOC entitlement that backfires when recruiters don't call.
But there are only 1,700 NFL players, compared to 50,000 in helmets in college and four million youth and prep. Nearly all the social impact of football occurs outside the NFL. It's youth, high school, and college players society should worry about.
Big college football programs graduate just 55 percent of players, compared a to 68-percent graduation rate for male students overall at the same universities. Florida State, this season's champion, graduates 58 percent of its football players, versus 71 percent for male Florida State students overall. Football players typically get five years instead of four, and don't pay for college; meanwhile, running out of money is the most common reason non-athlete undergraduates fail to complete degrees. So college players ought to graduate at a higher rate than students as a whole. Instead, nearly half are used up and thrown away—sold by their coaches a daydream of the NFL, when just three percent of big-college players ever take a snap in the pros.
Lack of diplomas is a greater problem in college football than lack of pay. A bachelor's degree adds $1 million to lifetime earnings, more than the typical college player could receive under any pay scheme. And the diploma confers on its recipients social mobility, which no proposed college football pay scheme addresses.
Big-college football with strong graduation rates is not pie-in-the-sky. My new book The King of Sports spends two chapters detailing how Virginia Tech has posted 20 consecutive winning seasons and played in the top bowl games, yet graduates 77 percent of its players. Virginia Tech caters to typical students, not the rare person who can both play football and be accepted by the admissions department at Notre Dame or Stanford. The Virginia Tech example shows big-college football really can promote education—if the university cares.
At the high-school level, football is a great experience, teaching self-discipline and teamwork. But too many programs operate like cults, pulling teens away from the classroom while instilling a sense of BMOC entitlement that backfires in senior year when recruiters don't call. One varsity player in 50 is offered either an NCAA scholarship or "ath admit" to college. Many wake up in December of senior year to discover their GPAs are too low, or extracurriculars too few, for regular college admission.
The rise in female educational achievement, as male achievement declines—documented by Hanna Rosin in her 2011 book The End of Men—must sync at least in part to large numbers of boys taking themselves out of the competition by spending so much of their teen years on football, which has become a year-round activity in many states. Athletics themselves can't be the issue, as girls' participation in high school sports is associated with increased women's success in college. But there is one high school sport girls do not play.
At the prep level, there is no meaningful informed consent. No 16-year-old will defy a coach who tells him to be a man and play through head pain.
What about high school concussions? Steven Broglio of the University of Illinois estimates prep football players sustain 43,200 to 67,200 concussions annually. That's versus 80 to 100 concussions annually in the NFL, where the attention focuses. In high school there is usually no certified athletic trainer on scene (fitness trainers are nice but often unskilled in medical matters), nor ready access to neurologists. The only health insurance many high school players have is Medicaid, which is stingy about specialists; their parents or guardians may avoid doctors, fearing co-pays. The result is a head-injury double whammy: High-school concussions are far more frequent than NFL concussions, plus more likely to be mistreated (if treated at all).
At the prep level, there is no meaningful informed consent. No 16-year-old—desperate to start for varsity, conditioned to obey adults—will defy a coach who tells him to be a man and play through head pain. Generally, children can't give informed consent in any case. But the care-and-custody legal standard that applies to their teachers generally does not bind their coaches.
In youth football, participation peaked two years ago and has tailed off a little since. But still, with three million involved, there are significantly more tackle football players below high-school age than above. If concussions happen in youth football at roughly half of the rate of the NFL, that's 75,000 brain injuries annually to boys (and a few girls) in elementary or middle school.
Research shows the accumulation of routine blows to the head can do as much brain harm as one spectacular knockout hit—which is especially dangerous for the young, whose brain cases are not finished developing. "Compared to adults, younger persons are at increased risk for traumatic brain injuries, with increased severity," the Centers for Disease Control has said.
If you think little guys don't hit hard enough to hurt each other's heads, think again. Virginia Tech researcher Stefan Duma put accelerometers into the helmets of the Auburn Eagles, a youth team—ages 7 and 8—in a town near campus. He found the typical player sustained 107 head impacts per season, most in practice. (Audiences see games; the majority of hits occur during drills and scrimmages.) Acceleration for the median hit equated to 15 times the force of gravity. Duma's tykes recorded 38 impacts of at least 40 "gees" and six impacts of 80 times the force of gravity, which is 95th percentile for NCAA football contact.
In a society increasingly education-based, having millions of boys smashing each other's heads from a very young age on—wearing helmets that were designed for adults and weigh more than helmets designed for children would—just cannot be good.
There are potential reforms for all the social problems caused by football. Public subsidies to the NFL can end. Today, there are huge rewards for victory, no penalties of any kind for failure to educate—so football-factory college programs could be given incentives to ensure that their players graduate. NCAA scholarships could be reimagined so players receive extra semesters, after athletic eligibility ends, to fix their credits and get degrees. High school practice hours and contact hours could be restricted.
And the NFL could stop encouraging little kids to sign up for tackle—good for the league's fan base and equipment sales, bad for little kids - and only promote flag football, which is a lot of fun. Eli and Peyton Manning did not put on pads and helmets until age 13. Neither should anyone else. As president, Barack Obama now has said twice that if he had a son, he would not let that son play football. What about other people's sons?


text:
Stanislav Tichavský (* 7. května 1937) byl český a československý politik Komunistické strany Československa, poslanec Sněmovny lidu Federálního shromáždění a ředitel automobilky Tatra Kopřivnice za normalizace.

Biografie
K roku 1976 se profesně uvádí jako ředitel podniku. Byl ředitelem automobilky Tatra Kopřivnice. V této funkci se připomíná ještě k roku 1989.

Ve volbách roku 1976 zasedl do Sněmovny lidu (volební obvod č. 124 – Nový Jičín, Severomoravský kraj). Mandát obhájil ve volbách roku 1981 (obvod Nový Jičín) a volbách roku 1986 (obvod Nový Jičín). Ve Federálním shromáždění setrval do konce funkčního období, tedy do svobodných voleb roku 1990. Netýkal se ho proces kooptací do Federálního shromáždění po sametové revoluci.

Odkazy

Reference

Externí odkazy
  Stanislav Tichavský v parlamentu

Narození v roce 1937
Čeští manažeři
Českoslovenští politici české národnosti
Poslanci československého Federálního shromáždění
Členové KSČ
Muži


text:
Q: vb.net buttonless delete in gridview i am trying to delete a record in my database via datagridview by just pressing the delete key but its giving me error "Index was out of range. Must be non-negative and less than the size of the collection.". here is my code
Private Sub DataGridView1_UserDeletedRow(sender As Object, e As DataGridViewRowEventArgs) Handles DataGridView1.UserDeletedRow

    For i = 0 To DataGridView1.Rows.Count - 1

        Dim deleterows As Integer = DataGridView1.SelectedRows(i).Cells(0).Value
        Dim sqlquery As String = "delete from tblname where ID = " & deleterows & ";"
        Dim sqlcommand As New OleDbCommand

        With sqlcommand
            .CommandText = sqlquery
            .Connection = conn
            .ExecuteNonQuery()
        End With

    Next

End Sub

A: I wonder if the problem lies with "DataGridView1.Rows.Count - 1"
it may not be performing the -1 calculation...
try (DataGridView1.Rows.Count - 1)

A: If you are wanting to use a loop to delete the rows, try going backwards through your rows (i.e. start at the last row and work your way back, instead of starting at the front and working forward).
For what you are describing, it might work better to leave the loop out all together (using your own code) :
 Dim deleterows As Integer = DataGridView1.SelectedRows(i).Cells(0).Value
 Dim sqlquery As String = "delete from tblname where ID = " & deleterows & ";"
 Dim sqlcommand As New OleDbCommand

 With sqlcommand
     .CommandText = sqlquery
     .Connection = conn
     .ExecuteNonQuery()
 End With