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News > Reuters Health Information
Pregnancy Not the Best Time to Lose Weight: Study
By C.E. Huggins
NEW YORK (Reuters Health) - Overweight and obese women who gain too few pounds, or even lose weight, during pregnancy may be putting their unborn child at risk, a new study suggests.
"While many people recommend that weight loss in pregnancy, particularly for very obese women is ok . . . (there) may be adverse effects," said Dr. Patrick Catalano, director of the Center for Reproductive Health at MetroHealth in Cleveland, Ohio.
"We don't have much data, in particular on body composition changes in overweight (or) obese women who lose weight," said Catalano, who led the new study. "Maybe we need to be a little bit more careful before we are just glib about saying it's ok."
Research has offered evidence of many risks posed by obesity to mother and fetus during pregnancy, up to and beyond the point of delivery.
Obese mothers are at raised risk of early spontaneous abortion and fetal birth defects. Later on, there is a higher chance of gestational diabetes and preeclampsia. At delivery, obese mothers are more likely to need a cesarean-section and to have postpartum wound infections.
The newborns of obese mothers are at risk of being overly large for their gestational age and that has been tied to childhood obesity.
The U.S. Institute of Medicine (IOM) issued guidelines in 2009 recommending that obese women gain between 5 and 9 kilograms (11 to 20 pounds) during pregnancy, which is somewhat less than the gain recommended for women who start pregnancy at a normal weight.
However, some researchers have suggested that for obese women, little to no weight gain, and even weight loss, is preferable during pregnancy to minimize the risks associated with obesity.
The American Congress of Obstetricians and Gynecologists recommends that individualized care be given to overweight or obese women who wish to gain less weight than recommended by the IOM.
Yet, little is known about the fetal health risks associated with weight loss or limited weight gain by overweight or obese women during pregnancy.
To investigate, Catalano, who was involved in developing the 2009 IOM guidelines, and his co-authors examined the effects of any weight loss or a weight gain of less than IOM's minimum 5 kg (11lbs).
They looked at 1,241 full-term singleton pregnancies among overweight and obese women.
Most (85%) of the women gained more than the IOM's minimum 5 kg during pregnancy, averaging a gain of 14.4 kg (32 lbs).
In contrast, 15% of the study participants had weight gains below IOM's minimum, averaging a gain of just 1.1 kg (2.4 pounds) while pregnant.
Infants born to women who gained little or no weight during pregnancy tended to be small for their gestational age, and had less lean body mass and less fat mass than infants born to women who gained more than 5 kg, Catalano and his team report in the American Journal of Obstetrics and Gynecology.
These infants also had a lower percentage of body fat, a smaller head circumference, lower birth weight and were smaller in length than infants born to women who gained more than 5 kg during pregnancy.
The results held when the authors took into account the mothers' pre-pregnancy weight, smoking status, glucose tolerance and other factors that may have influenced the infants' development.
Infants born to 46 women who lost weight during pregnancy were also small for their gestational age and had decreased lean and fat mass, lower birth weight and a lower percentage of body fat.
In contrast, infants born to women who gained more than the IOM minimum were more likely to be large for their gestational age. Among infants born to women who gained more than 5 kg, 13% were large for their gestational age. In comparison, 7.5% of infants born to women who gained 5 kg or less were large.
"Everyone agrees having a very big baby is not good," Catalano said. However, "the loss of lean mass may have long-term consequences" as well, he said.
What's the bottom line for obese and overweight women? "Lose weight between pregnancies," Catalano recommends. "We just don't know if it's safe to do during pregnancy."
SOURCE: http://bit.ly/1d6I6zG
Am J Obstet Gynecol 2014.
Reuters Health Information © 2014
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This book draws upon economic and political theory as well as recent history in examining the legal system's role in American society. By demonstrating the evolution legal institutions have undergone since the nation's founding, the author provides a view of modern-day judicial and regulatory processes which is both unexpected and disturbing. Due to this evolution, the courts and regulatory agencies have become the predominant forums for addressing societal disputes whether or not those disputes are amendable to legal resolution. Non-legal dispute resolution alternatives are undergoing steady diminution as political and economic power accrues to a legal aristocracy which seeks profit-maximization and the capture of influential policy-making roles. Contents: Introduction; Foundations of the American Legal System; The Evolution of Legal Standards; Minimization of Risk Through Law; Judicial Government; Social Impacts of the Legal System; The Law Industry; Toward a New Legal Paradigm; References.
James Robert Forcier is Adjunct Instructor at Golden Gate University and Regulatory Property Manager at Pacific Bell in San Francisco.


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New Jersey Moves to Ban Asbestos Products
By: Devin Golden on March 7, 2019
The United States government has loosened asbestos-related restrictions, but some states have implemented asbestos regulations to reduce resident exposure to the harmful substance.
New Jersey may join the list — and in a significant way.
The state's legislature passed a bill that outlaws buying, selling or disseminating products that include asbestos, a fibrous material often used in construction and insulation materials until the 1980s. Asbestos exposure is a primary cause for the development of numerous deadly diseases, including mesothelioma.
Passing the bill would prevent asbestos use in cars, buildings and fertilizer and could reduce mesothelioma rates among New Jersey residents. If the legislation becomes law, it could become an example for other states — and the federal government — looking to improve their residents' health.
What the Asbestos Law Would Do
Tapinto.net, an online news source for Morristown, New Jersey, reports that state assembly members Lisa Swain, Robert Karabinchak and Britnee Timberlake spearheaded the proposal. The New Jersey Senate unanimously approved the resolution on Feb. 21. The bill awaits executive approval before New Jersey becomes the first state to completely ban all products that include asbestos.
The proposed asbestos law includes a fine of up to $2,500 for violators. The state's Department of Environmental Protection could also seek additional penalties.
Tapinto.net reports that New Jersey's potential outlaw of all asbestos products is a response to the federal government's loosening of restrictions. The Environmental Protection Agency changed regulations in 2018 and now allows the manufacturing of asbestos-included products on a case-by-case basis.
Why Asbestos Is Dangerous
Asbestos exposure is a significant health concern for United States residents. People who worked in construction, mining or on U.S. Navy ships were likely exposed to the substance. Other ways that people have come into contact with asbestos include asbestos-abatement jobs and secondhand asbestos exposure from a friend or family member.
People can inhale or ingest asbestos, which attaches to the tissue that separates a person's chest cavity and lungs, abdomen and heart. Asbestos buildup on the tissue can result in the development of cancerous cells and a tumor.
Education regarding the dangers of asbestos is essential, especially for people or loved ones of those who have worked in an industry that used or still uses the substance. Asbestos exposure usually occurs without the person's knowledge, which is why early detection of mesothelioma is difficult. If you or a loved one is experiencing symptoms related to the rare cancer, seek medical attention immediately.
Additionally, anyone diagnosed with mesothelioma may be eligible to receive compensation due to asbestos exposure. Mesothelioma Guide can help you connect with asbestos legal experts. For more information, contact our patient advocates either by calling 888-385-2024 or complete our free case evaluation form.
NJ Lawmakers Ban Asbestos. Tap into Morristown. Retrieved from: https://www.tapinto.net/towns/morristown/articles/nj-lawmakers-ban-asbestos-2. Accessed: Feb. 27, 2019.
U.S. Federal Bans on Asbestos. United States Environmental Protection Agency. Retrieved from: https://www.epa.gov/asbestos/us-federal-bans-asbestos. Accessed: Feb. 28, 2019.

redpajama_set_name: RedPajamaCommonCrawl


Failed to instantiate file "ContentQueryMain.xsl" from module "XSLStyleSheets": The specified list does not exist.
When deploying a custom branding solution to one of our customer's environments, we ran into "Failed to instantiate file "ContentQueryMain.xsl" from module "XSLStyleSheets": The specified list does not exist." when we activated the publishing features on the site collection. After some investigation, it seemed that the ContentQueryMain.xsl should exist in a subfolder XSLStyleSheets within the Style Library (which actually gets created by this feature).
In my case there was no Style Library though. Nevertheless, creating a new Style Libary resulted in the url being "Style%20Library1", which meant that SharePoint did find the Style Library somewhere, I was just not seeing it. Opening the site with SharePoint Designer 2010 as a site collection admin gave me the option to choose All Files to see the content of the site. And there I could see the Style Library. I renamed it to Style_Library_Error and closed down SharePoint Designer.
Afterwards, I created a Document Library called Style Library. Now the URL was showing me properly Style%20Libary.
Thanx a lot, this really did the job for me! I have looked quite some time for a good solution, but this was what worked for me.
This saved me a headache. Great post, thanks!!
I located and deleted the previous Style Library and received the same error. It was recreated during reactivation of the feature. Seems something else is amiss.
I was indeed a very helpful article..it fixed my customer's issue…great!


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Boards o' Magick - The Stuff of Legends, Right Boo?
Home Forums > Miscellaneous Forums > Booktalk >
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Which book are you reading currently? #7
Discussion in 'Booktalk' started by Enagonios, Sep 7, 2007.
joacqin Confused Jerk Veteran
Those threads will be explored more fully. Seems like Erikson and Esslemont have divided up the characters which is why we have read so little about some of them despite them obviously being very important for the story and setting. Dassem Ultor is one of them and you will get quite a lot of him in Return.
joacqin, Mar 8, 2010
Chandos the Red This Wheel's on Fire
Thanks for the info, Joac. At the moment, it's Shadowrise by Tad Williams.
"It's called the American Dream because you have to be asleep to believe it." - George Carlin
Chandos the Red, Mar 9, 2010
Started "Watership Down" by Richard Adams. Remember finding the animated movie very scarey as a kid and I have read that it is essential reading. So far so good.
Saber A revolution without dancing is not worth having! Veteran
Just got Robin Hobb's new book. I will start once I have less work!
joacqin, I have similar memories as a child of that movie... there were a lot of bunnies killing each other if I recall correctly.
Saber, Mar 11, 2010
Triactus United we stand, divided we fall Veteran
Say what? Bunnies killing each other? What kind of movies your parents let you guys watch??
Tri-cactus, you damned do-goody-two-shoes! -- Disciple of the Watch
Triactus, Mar 11, 2010
Ziad I speak in rebuses Veteran
I believe Saber's talking about the Watership Down cartoon. Watching it as an adult, you will note how odd it is for a child's cartoon to have so much violence and blood. Watching it as a child... let's just say it's high octane nightmare fuel. I have no idea how or why it was aimed at children.
Ziad, Mar 11, 2010
Enagonios Gems: 31/31
Latest gem: Rogue Stone
high octane nightmare fuel, heh, i like that.
i finished "the devil you know" by mike carey, the writer of the lucifer comics and a couple of runs on hellblazer. pretty good stuff. felix castor (the main character) is kind of like john constantine, but a nice guy instead of a prick.
now i'm reading "in the name of rome" by adrian goldsworthy. kind of like a who's who of 15 of the arguably greatest roman generals and an overview of their campaigns and most famous battles and strategies.
If you can cheat, so can I. I won't let you beat me unfairly - I'll beat you unfairly first. -Ender
Enagonios, Mar 28, 2010
Scythesong Immortal Gems: 19/31
Latest gem: Aquamarine
Took a short break from books, read some internet fiction. Recently stumbled on this old Arcanum playthrough. It has pictures and stuff. So far it's been an interesting read, I've never played Arcanum before.
Scythesong Immortal, Apr 3, 2010
Merlanni ★ SPS Account Holder Veteran New Server Contributor [2012] (for helping Sorcerer's Place lease a new, more powerful server!)
I found a second hand copy of a Legend of the five Rings book. Anybody knows about it?
Merlanni, Apr 3, 2010
dmc Speak softly and carry a big briefcase Staff Member Distinguished Member ★ SPS Account Holder Resourceful Adored Veteran New Server Contributor [2012] (for helping Sorcerer's Place lease a new, more powerful server!)
The Phantom Tollbooth. My daughter and I are reading it together, taking turns each paragraph. What a great book! I highly recommend it to anyone with kids from 8 to 18.
dmc, Apr 6, 2010
wolf of the plains by conn igulden. fictional account of genghis khan's orgin story. i'm around halfway through already, gripping stuff
Enagonios, Apr 6, 2010
The Kilted Crusader The Famous Last words "Hey guys, watch THIS!" Veteran
The Bro Code by Barney Stinson! Great wee read if you're in need of a chuckle
The Kilted Crusader, Apr 7, 2010
lords of the bow by conn iggulden, the next book in the genghis series.
Blades of Vanatar Vanatar will rise again Adored Veteran Pillars of Eternity SP Immortalizer (for helping immortalize Sorcerer's Place in the game!)
Book 1 of th Sovereign Stone trilogy - Well of Darkness - by Margaret Weis and Tracy Hickman. Looking forward to the next 2 books.
"Still round the corner there may wait, a new road, or a secret gate." - J.R.R. Tolkien
Blades of Vanatar, Apr 19, 2010
Blades of Vanatar said: ↑
Is that the Dragonlance universe? I stopped after the war of souls trilogy. I dunno, everything after the Twins trilogy is not as good...
Triactus, Apr 19, 2010
No Tri, this series was based on another game world. I liked their non-Krynn series'. The Death Gate Cycle and The Darksword series were pretty decent reads. Some of the later DL stuff got lame though.
Just started William Faulkner's Go down, Moses. Still too early to say anything about it except it seems to be in typical Faulkner fashion.
Triactus said: ↑
The Twins trilogy is my favourite but Dragon of Summer Flame was quite good too. The Second Generation was odd because it seems so disconnected from everything (and from itself) but some of the stories take on a very different meaning when you get into Summer Flame. War of Souls had some great bits but I really didn't like the whole "I stole it all" business, it just seemed to come out of nowhere even though the build up to it had some really good scenes, such as the death of you-know-who at the end of book 2. Death Gate is next on my to-read list actually, I've heard some very good things about it.
Ziad, Apr 19, 2010
Ziad said: ↑
The Twins trilogy is my favourite but Dragon of Summer Flame was quite good too.
To me, even the Twins trilogy, although quite enjoyable, didn't compare to the original books. They were great! The problem I have with Dragons of summer flame is
that it seems there were too much effort in erasing everything magical. Almost every surviving character from the first books died in this one, it's hinted that the elves go away, same for the gods and for magic (although they put a spin on this in the following books, maybe because of bad fan reaction?). It just felt like they were trying too hard to end it.
Somehow Dragonlance just does not have it. I prefer Forgotten realms and Ebberon.
The Deed of Paksenarrion by Elizabeth Moon.
Merlanni, Apr 20, 2010
Tri - I prefer the Twins to the original trilogy actually. The Chronicles felt too much like the novelisation of a D&D campaign (which is exactly how they started IIRC) rather than novels in their own right. I think your problem with Summer Flame comes from TSR's attempt to radically change the magic system in Dragonlance. I think the reason they reverted back to the regular one with War of Souls was because WotC had taken over by then and probably wanted the older system back.
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Gail Kerr: Mayor Dean lays down gauntlet on school funding issue
Nashville's mayor has only one power when it comes to Metro public schools: funding.
The mayor cannot technically tell the elected school board what to do. He or she can only recommend how much money the schools get in the annual city budget, which the Metro Council can change if it so chooses.
But make no mistake about it. Mayor Karl Dean has thrown down a gauntlet, making it clear that he's fed up with the endless sniping by school board members and officials about charter schools, which Dean unabashedly supports. And unless they change their direction, school officials had best prepare to feel it in their checkbook come spring budget hearings.
The issue is whether charter schools drain the resources of regular public schools. School board members and Director Jesse Register say they do, to the tune of $23 million next year. They argue that the per-pupil amount the state budgets for schools disappears from regular classrooms when it goes to charters. Dean and charter proponents say only 8 percent of public school students attend charters, and the shift they take in tax dollars away from regular classrooms is no more than that which is shifted to magnet schools.
"Let me be clear," Dean said in a speech as the Nashville Area Chamber of Commerce issued its annual report card on schools. "I don't think the issue that we have in front of us with our schools is totally a resource issue. Instead, I believe it's time to take a hard look at where our existing resources are (allocated)."
Dean reminded the audience that he has funded Metro schools at record levels every year, with the backing of the council. The schools budget is $125 million more than when he took office in 2007. "However that does not mean we can afford or should continue the sizable year after year increases we've given the schools in previous years."
He reminded them that money included revenue from a property tax hike in 2012.
"That's not an option again," Dean said. "No department gets a blank check, and that includes schools."
Dean's unexpectedly blunt statement came on the heels of two key chamber officials criticizing the school board in an editorial board meeting with The Tennessean. The results of the chamber report card, which made five recommendations, just about got lost in the process.
"There's been a lot of time and effort wasted over this past year on the issue" of charter schools, said Marc Hill, the chamber's chief policy officer and education guru.
Chamber President Ralph Schulz was equally candid: "Every minute you spend arguing the issue of charters — and who's in charge and who's not in charge and what's imposed and what isn't imposed — you're taking away from the discussion on: 'How are we going to effectively improve student achievement?' It's an ongoing discussion, and it's not necessarily productive."
The chamber found the school system had "mixed results." It recommended five things, among them that schools stay the course on the new tougher core curriculum, and that Metro students be allowed to ride public buses for free to encourage more school choice.
Unlike last year's report card, the chamber did not weigh in directly on charters. Chamber officials did praise the school board for finally coming up with a strategic plan on directing charter growth, even though many charter proponents think the board's new policy is too limiting. The new policy allows charters only in areas of Nashville that have overcrowded or failing schools. That means mainly South Nashville/Antioch.
Register responded to Dean's comments, pledging to take a "hard look" at every line item in the budget as he said they do every year. The drain from charters, he said, is not "a myth. I consider fiscal impact to be a very important discussion."
But at least one school board member seemed to hear Dean loud and clear. Will Pinkston said the public is tired of hearing the back-and-forth about charters: "People are ready to talk about scalable improvement that reaches all schools."
Truer words have rarely been spoken. But make no bones about it. Dean is also ready to talk turkey. In particular, the price of turkey.
Gail Kerr's column runs on Sundays, Mondays and Wednesdays. Reach her at 615-259-8085 or gkerr@tennessean.com.


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Will Space Be A Topic at Thursday's Republican Presidential Primary Debate? – UPDATE
By Marcia Smith | Posted: August 5, 2015 12:00 am ET | Last Updated: August 7, 2015 12:04 pm ET
UPDATE, August 7, 2015: No space policy questions arose at the debate.
ORIGINAL STORY, August 5, 2015: The 10 Republican presidential candidates who will debate each other in prime time on Thursday were selected by Fox News on Tuesday based on an average of five national polls. Among them are former Florida governor Jeb Bush who recently said he is "a space guy," and Senators Ted Cruz (R-TX) and Marco Rubio (R-FL), both of whom made statements yesterday in support of Senate passage of a commercial space bill. While space activities rarely rise to the fore in presidential primary debates, it did happen in 2012. Perhaps it will this time, too.
Cruz is the sponsor of S. 1297, the Commercial Space Launch Competitiveness Act, which passed the Senate yesterday (August 4). Rubio of one of four cosponsors.
Following Senate passage, Cruz invoked the memory of President Ronald Reagan, saying the bill carried forward "President Reagan's torch" by continuing to support commercial space. The original Commercial Space Launch Act was enacted during Reagan's presidency. In addition to provisions dealing directly with commercial space launch issues, the bill also extends the U.S. commitment to operating the International Space Station to 2024. Reagan initiated the space station program in his 1984 State of the Union Address. Cruz also tied the bill to his home state interests, saying that it demonstrates Texas has a "major stake in space exploration" and Johnson Space Center employees "will continue to play a vital role in the future" of human spaceflight. Cruz has also made clear his support for space exploration during Senate hearings, arguing that exploration of space, not studying the earth, should be NASA's priority.
One provision of S. 1297 extends through 2020 the "learning period" during which the FAA cannot issue additional commercial human spaceflight regulations. Sometimes called a "moratorium," it is set to expire on September 30, 2015. The idea is that the commercial human spaceflight industry needs time to gain experience before decisions are made on what, if any, more regulation is needed.
It may be that provision Rubio was referring to in his statement that "we need to eliminate unnecessary regulations that cost too much and make it harder for American innovators to create jobs." He added that the reforms in the bill will "make it easier for our innovators to return Americans to suborbital space" and "help the American space industry continue pushing further into space than ever before." Like Cruz and other Senators who commented on the bill, he tied it to home state interests calling it "an important win for Florida's space exploration community."
For his part, Bush championed an increase in NASA funding during an interview with the New Hampshire Union Leader in Manchester, NH, enthusing that "I'm a space guy."
People were allowed to send in questions to Fox News that they want the candidates to answer. At least one is about space policy. Michael Listner, founder and principal of Space Law & Policy Solutions in New Hampshire, tweeted today that he submitted one.
Submitted my video question on #spacepolicy for consideration for @FoxNews Presidential Debate.
— Michael J. Listner (@ponder68) August 4, 2015
Whether or not it or any other space policy question gets asked is problematical, of course. The two-hour debate has 10 candidates and three co-moderators. How many questions can be reasonably asked and answered in that time span with so many participants will be interesting to watch. The debate airs on Fox News Channel and is being conducted in partnership with Facebook. It is being held in Cleveland, Ohio.
The 10 candidates who made the cut to be in the prime time debate at 9:00 pm EDT are (in order of their standing in the polls yesterday from highest to lowest):
Donald Trump (billionaire businessman)
Jeb Bush (former Florida governor)
Scott Walker (current Wisconsin governor)
Mike Huckabee (former Arkansas governor)
Ben Carson (commentator and retired neurosurgeon)
Ted Cruz (Senator from Texas)
Marco Rubio (Senator from Florida)
Rand Paul (Senator from Kentucky)
Chris Christie (current New Jersey governor)
John Kasich (current Ohio governor)
Seven other Republican presidential candidates who ranked lower in the polls will appear in a separate one-hour debate at 5:00 pm EDT. They are:
Rick Perry (former Texas governor)
Rick Santorum (former Senator from Pennsylvania)
Bobby Jindal (current Louisiana governor)
Carly Fiorina (former CEO of Hewlett Packard)
Lindsey Graham (Senator from South Carolina)
George Pataki (former New York governor)
Jim Gilmore (former Virginia governor)
During the 2012 Republican presidential primaries, candidate Newt Gingrich, a former Speaker of the House, laid out bold goals for the space program, and he and Mitt Romney responded to questions about the space program in one of the televised debates.
Last Updated: Aug 07, 2015 12:04 pm ET
Civil, Commercial, International, Military


Did you know that 1 in 4 homes will be affected by termites at some point in its life? They might be little but they can do an enormous amount of damage in a relatively short amount of time and your insurance probably doesn't cover you for this type of damage.
This is why we suggest that you always have a pre-purchase pest inspection before buying a new home, as well as regular maintenance checks over the years to come.
But there are things you can do to reduce your chances of attack and there are many options when it comes to detection, barrier protection and treatments.
Regular maintenance inspections can greatly reduce potential damage by identification of conducive conditions which are attractive to termites, small changes can often make an area unattractive or inhabitable, thus preventing the problem before it begins and the early detection of an attack can limit the damage done, minimising any repairs necessary.
At Prescan we use both traditional techniques and state of the art equipment to detect Termites and other Timber pests like Borers and Fungi and we strongly recommend anyone looking at purchasing a home to have one of our Timber Pest Inspections done before buying.
You can either have us conduct your Pre-Purchase or Maintenance Pest inspection on its own, or combine it with a pre-purchase building inspection.


-Get the Bedtime Routine down!
E is almost two, so she couldn't quite give us her intentions, but I'll make some for her.
We write ours in a brainstorm bubble format, and post in a conspicuous place so we can see them often! I like to revisit mine quarterly so that I can adjust my goals as needed. The point of intentions is not to shame, but to be doable and encouraging.
I love intentions not resolutions! Too many times resolutions don't get done which leads to guilt which leads to shame. Just the title Intention makes you feel better about making it because it makes you feel like you're actually going to get it done. Thank you for this!
Next Post When the Winter Blows… 5 ways to feel better about it!


Supreme Court Justice Ruth Bader Ginsburg underwent a procedure Friday in New York City to remove two nodules on her lung that were determined to be malignant.
The pulmonary lobectomy was performed at Memorial Sloan Kettering Cancer Center to remove the nodules from her left lung. They were discovered during tests in November to diagnose and treat rib fractures Ginsburg sustained from a fall.
There was no evidence of any remaining nodules after the operation was performed and pre-operation scans did not detect disease anywhere else in her body.
She is resting comfortably and no further treatment is planned, according to the press release. She will remain in the hospital for a few days.
The justices are not due back on the bench for oral arguments again until Jan. 7, but they are scheduled to meet for their first conference of the new year on Jan. 4.
Ginsburg, the Supreme Court's oldest justice, has had two previous bouts with cancer. In 1999, she underwent treatment for colorectal cancer, and in 2009, she was treated for pancreatic cancer.
Those who have praised Ginsburg as the court's leading liberal have expressed concerns about the 85-year-old justice's well-being, some jokingly offering to donate ribs or cloak her in bubble wrap.
Another vacancy on the high court would likely lead to another explosive fight with liberals trying to prevent President Trump Donald John TrumpRussia's election interference is a problem for the GOP Pence to pitch trade deal during trip to Michigan: report Iran oil minister: US made 'bad mistake' in ending sanctions waivers MORE from turning the court into a conservative stronghold with a third nominee.
— Lydia Wheeler contributed to this developing report, which was last updated at 12:46 p.m.


Edinburgh, Scotland, UK; 2 August, 2018. Painting Head of a Clown by artist Edwin G. Lucas at a preview of new exhibition by the artist at City Art Centre in Edinburgh. Edwin G. Lucas (1911-1990) was one of the most unique Scottish painters of the 20th century. Born and raised in Edinburgh, he channelled the influence of Surrealism in his work, cultivating an original and highly imaginative style of painting during the 1940s and 50s that set him apart from his contemporaries. Today, however, he is virtually unknown.


text:
Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases
Julian E. Fuchs, Ines G. Munoz, David Timson, Angel L. Pey
School of Pharmacy and Biomolecular Sci
Theoretical and experimental evidences have shown that protein function, regulation and degradation are intrinsicallylinked to the dynamic and fluctuating nature of protein ensembles. However, the effect of missense mutations on catalytic performance are often interpreted from conformational analyses derived from X-ray crystallography, molecular dynamics and modeling, while effects on conformational fluctuations at the active site as the source of catalytic defects are rarely investigated. Here, we explore the role of conformational fluctuations in the catalytic efficiency of WT and three missense mutations in the UDP-Galactose 4´-epimerase (GALE) protein causing type III galactosemia. Using comprehensive molecular dynamics simulations and small angle X-ray scattering we correlate low NAD+ binding affinity in some mutants with an increased population of non-competent conformations for NAD+ binding. Proteolysis studies combined with thermodynamic calculations reveal that mutations affecting GALE catalytic performance favor larger conformational fluctuations at the N-terminal domain and NAD+ binding site, shifting the equilibrium towards non-binding competent states in the native ensemble. Therefore, we provide a novel ensemble-based thermodynamic mechanism to explain catalytic defects caused by missense mutations that links large and transient conformational fluctuations and loss of catalytic efficiency and substrate/coenzyme affinity. In the context of this mechanism, we propose that allosteric ligands aimed at modulating these transient conformational fluctuations might correct catalytic defects in inherited metabolic diseases, representing a different approach to current small ligand therapies which target the low stability, but notcatalytic defects, of mutations.
https://doi.org/10.1039/C6RA05499D
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence
10.1039/C6RA05499DLicence: CC BY
c6ra05499d.pdfFinal published version, 1.44 MBLicence: CC BY
Fingerprint Dive into the research topics of 'Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases'. Together they form a unique fingerprint.
Missense Mutation Medicine & Life Sciences
Inborn Genetic Diseases Medicine & Life Sciences
Thermodynamics Medicine & Life Sciences
galactose epimerase Medicine & Life Sciences
UDPglucose 4-Epimerase Medicine & Life Sciences
Galactosemias Medicine & Life Sciences
Fuchs, J. E., Munoz, I. G., Timson, D., & Pey, A. L. (2016). Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases. RSC Advances, 6(63), 58604-58612. https://doi.org/10.1039/C6RA05499D
Fuchs, Julian E. ; Munoz, Ines G. ; Timson, David ; Pey, Angel L. / Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases. In: RSC Advances. 2016 ; Vol. 6, No. 63. pp. 58604-58612.
@article{881b0a2b9f5f4a20b8403c416eeb90ab,
title = "Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases",
abstract = "Theoretical and experimental evidences have shown that protein function, regulation and degradation are intrinsicallylinked to the dynamic and fluctuating nature of protein ensembles. However, the effect of missense mutations on catalytic performance are often interpreted from conformational analyses derived from X-ray crystallography, molecular dynamics and modeling, while effects on conformational fluctuations at the active site as the source of catalytic defects are rarely investigated. Here, we explore the role of conformational fluctuations in the catalytic efficiency of WT and three missense mutations in the UDP-Galactose 4´-epimerase (GALE) protein causing type III galactosemia. Using comprehensive molecular dynamics simulations and small angle X-ray scattering we correlate low NAD+ binding affinity in some mutants with an increased population of non-competent conformations for NAD+ binding. Proteolysis studies combined with thermodynamic calculations reveal that mutations affecting GALE catalytic performance favor larger conformational fluctuations at the N-terminal domain and NAD+ binding site, shifting the equilibrium towards non-binding competent states in the native ensemble. Therefore, we provide a novel ensemble-based thermodynamic mechanism to explain catalytic defects caused by missense mutations that links large and transient conformational fluctuations and loss of catalytic efficiency and substrate/coenzyme affinity. In the context of this mechanism, we propose that allosteric ligands aimed at modulating these transient conformational fluctuations might correct catalytic defects in inherited metabolic diseases, representing a different approach to current small ligand therapies which target the low stability, but notcatalytic defects, of mutations.",
author = "Fuchs, {Julian E.} and Munoz, {Ines G.} and David Timson and Pey, {Angel L.}",
note = "This article is licensed under a Creative Commons Attribution 3.0 Unported Licence",
doi = "10.1039/C6RA05499D",
journal = "RSC Advances",
Fuchs, JE, Munoz, IG, Timson, D & Pey, AL 2016, 'Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases', RSC Advances, vol. 6, no. 63, pp. 58604-58612. https://doi.org/10.1039/C6RA05499D
Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases. / Fuchs, Julian E.; Munoz, Ines G.; Timson, David; Pey, Angel L.
In: RSC Advances, Vol. 6, No. 63, 13.06.2016, p. 58604-58612.
T1 - Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases
AU - Fuchs, Julian E.
AU - Munoz, Ines G.
AU - Timson, David
AU - Pey, Angel L.
N1 - This article is licensed under a Creative Commons Attribution 3.0 Unported Licence
N2 - Theoretical and experimental evidences have shown that protein function, regulation and degradation are intrinsicallylinked to the dynamic and fluctuating nature of protein ensembles. However, the effect of missense mutations on catalytic performance are often interpreted from conformational analyses derived from X-ray crystallography, molecular dynamics and modeling, while effects on conformational fluctuations at the active site as the source of catalytic defects are rarely investigated. Here, we explore the role of conformational fluctuations in the catalytic efficiency of WT and three missense mutations in the UDP-Galactose 4´-epimerase (GALE) protein causing type III galactosemia. Using comprehensive molecular dynamics simulations and small angle X-ray scattering we correlate low NAD+ binding affinity in some mutants with an increased population of non-competent conformations for NAD+ binding. Proteolysis studies combined with thermodynamic calculations reveal that mutations affecting GALE catalytic performance favor larger conformational fluctuations at the N-terminal domain and NAD+ binding site, shifting the equilibrium towards non-binding competent states in the native ensemble. Therefore, we provide a novel ensemble-based thermodynamic mechanism to explain catalytic defects caused by missense mutations that links large and transient conformational fluctuations and loss of catalytic efficiency and substrate/coenzyme affinity. In the context of this mechanism, we propose that allosteric ligands aimed at modulating these transient conformational fluctuations might correct catalytic defects in inherited metabolic diseases, representing a different approach to current small ligand therapies which target the low stability, but notcatalytic defects, of mutations.
AB - Theoretical and experimental evidences have shown that protein function, regulation and degradation are intrinsicallylinked to the dynamic and fluctuating nature of protein ensembles. However, the effect of missense mutations on catalytic performance are often interpreted from conformational analyses derived from X-ray crystallography, molecular dynamics and modeling, while effects on conformational fluctuations at the active site as the source of catalytic defects are rarely investigated. Here, we explore the role of conformational fluctuations in the catalytic efficiency of WT and three missense mutations in the UDP-Galactose 4´-epimerase (GALE) protein causing type III galactosemia. Using comprehensive molecular dynamics simulations and small angle X-ray scattering we correlate low NAD+ binding affinity in some mutants with an increased population of non-competent conformations for NAD+ binding. Proteolysis studies combined with thermodynamic calculations reveal that mutations affecting GALE catalytic performance favor larger conformational fluctuations at the N-terminal domain and NAD+ binding site, shifting the equilibrium towards non-binding competent states in the native ensemble. Therefore, we provide a novel ensemble-based thermodynamic mechanism to explain catalytic defects caused by missense mutations that links large and transient conformational fluctuations and loss of catalytic efficiency and substrate/coenzyme affinity. In the context of this mechanism, we propose that allosteric ligands aimed at modulating these transient conformational fluctuations might correct catalytic defects in inherited metabolic diseases, representing a different approach to current small ligand therapies which target the low stability, but notcatalytic defects, of mutations.
U2 - 10.1039/C6RA05499D
DO - 10.1039/C6RA05499D
JO - RSC Advances
JF - RSC Advances
Fuchs JE, Munoz IG, Timson D, Pey AL. Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases. RSC Advances. 2016 Jun 13;6(63):58604-58612. https://doi.org/10.1039/C6RA05499D


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What Would JT Do?
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British headmaster says Harry Potter and other fiction causes brain damage in children.
May 10, 2016 by JT Eberhard
British headmaster says Harry Potter and other fiction causes brain damage in children. May 10, 2016 JT Eberhard
A British headmaster at the Acorn School in Nailsworth has gotten some attention for claiming that fiction such as Harry Potter can cause mental illness in children:
Can reading "Harry Potter," "The Hunger Games" and "The Lord of the Rings" cause brain damage in children?
The principal of a British private school says yes.
In a lengthy blog post that went viral over the weekend, Graeme Whiting, the headmaster of the Acorn School in the English town of Nailsworth, claimed that popular fantasy books "can damage the sensitive subconscious brains of young children, many of whom may be added to the current statistics of mentally ill young children."
Whiting also criticized books by authors George R.R. Martin and Terry Pratchett, claiming they "contain deeply insensitive and addictive material which I am certain encourages difficult behaviour in children."
The principal lamented the fact that children can buy these books without a "Special licence."
"Buying sensational books is like feeding your child with spoons of added sugar," Whiting wrote, "heaps of it, and when the child becomes addicted it will seek more and more, which if related to books, fills the bank vaults of those who write un-sensitive books for young children!"
Whiting praised the "old-fashioned values of traditional literature," offering as examples William Shakespeare, John Keats, Charles Dickens and "Shelley." (He didn't specify whether he meant Percy Bysshe Shelley, author of "The Necessity of Atheism," or Mary Shelley, author of the pioneering horror novel "Frankenstein.")
The principal ended his post with the lines, "Beware the devil in the text! Choose beauty for your young children!"
I like Shakespeare as much as the next guy (maybe even more, I've read all of his plays). Does Whiting know just how much wanton violence, depicted as perfectly real, is in Shakespeare? Harry Potter has nothing on ol' Will. If you compare body counts between Shakespeare and Rowling, it wouldn't even be a close contest.
Anyway, I strongly suspect that Whiting didn't consult any psychological experts before forging his opinion on the matter, so I went ahead and did that. The first person I pinged was Jeremiah Beene, PhD student at Ole Miss and expert on the psychology of mass murderers, specifically on whether or not violent video games cause violent behaviors (he also is co-host of both the Game Theory Podcast and the God Theory Podcast). Jeremiah sent me this quote:
This is a classic example of what the lead researcher in the (non)effects of violent media, Chris Ferguson, calls "juvenophobia." Every generation has a fondness of how they were brought up, with every aspect adored and believed to be critical in their overall development. When they see the disparity of how today's youth are raised, they instantly place a moral judgment on the issue. The whole thing is a textbook case of confirmation bias. You like who you are, you think you turned out the way you turned out because of x, y, and z, and then you begin seeking out proof for that belief. And, now you just need to dust off that old soapbox so everyone else can hear your oh-so-real moral crisis.
As for science, no. Absolutely not. There are documented cases from Plato's time that people were terrified of what plays and open readings of poems would do to the youth all the way through books, radio shows, movies, and video games. They just won't let it rest that humans are very, very good at contextualizing fiction.
Next I messaged my wife who has an undergrad in neuroscience and this coming July will start med school with a focus on either psychiatry or neurology:
There's a lot of studies that show reading fiction is correlated with higher levels of empathy. Anything by Mar or Oatley in the past 10 years is good.
In 2009 they even accounted for personality type, and afterward the amount of fiction one reads still positively predicted one's score on an exercise of empathy.
The wife then sent me a link to one such study. Here's the abstract (bold mine):
Readers of fiction tend to have better abilities of empathy and theory of mind (Mar et al., Journal of Personality 74: 1047–1078, 2006). We present a study designed to replicate this finding, rule out one possible explanation, and extend the assessment of social outcomes. In order to rule out the role of personality, we first identified Openness as the most consistent correlate. This trait was then statistically controlled for, along with two other important individual differences: the tendency to be drawn into stories and gender. Even after accounting for these variables, fiction exposure still predicted performance on an empathy task. Extending these results, we also found that exposure to fiction was positively correlated with social support. Exposure to nonfiction, in contrast, was associated with loneliness, and negatively related to social support.
So yeah, it turns out the exact opposite is true. Whiting could have easily known that if he'd just asked people who study the subject (or if he had consulted Dr. Google).
But after reading his blog post, I'm even more coming to think this man doesn't have the first clue about what he's saying, thanks in part to stuff like this:
"…as they do not have thinking brains until, at the earliest, fourteen years of age."
To once again quote my wife: "wtf?"
I'm also starting to think he's kind of full of himself thanks to passages like this:
It may take the readers of this blog a lifetime to fully appraise what the school represents, and why I chose to give children an education based on moral values and individual teaching in each class of children, which enriches their imagination.
News flash: you don't enrich the imagination of children by denying them access to some of the greatest imaginations of all time. Imagination is a skill that grows in contact with other dreamers, a fact that is patently obvious even if you are unaware of the relevant science.
Far from taking a lifetime to fully appraise what the school represents, it took me about a half an hour. I messaged experts, they messaged back, and now it's apparent your school stands for babying children to such a degree you deny them much of the wonder you purport to be instilling.
Arkansas man wants to raise $23 million to overthrow the government. Wants bible taught instead of common core.
May 10, 2016 Rabbis behind Jewish private school under investigation for not teaching secular subjects.
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Rael was already proving himself to be a provokingly fascinating teacher. He had the rare skill of creating a thirst for knowledge by sketching bare outlines of subjects drawn in attractive forms and colours that excited interest expectation, and desire, then quietly turning aside, for a time, without satisfying the appetite he had created. In this lay the great beauty and fertility of his design. A coveted treasure, discovered, out of reach, lost, sought for, and finally found, is far more precious than if it had been a plaything of our nursery.
I had been told that I was approaching the most momentous step in the soul's pilgrimage. How calmly, even cursorily, Rael had seemed to deal with it. Just a passing reference, then he turned abruptly to another subject equally engrossing, which he dismissed with similar brevity, then the door of opportunity was closed, and I had to stifle the flood of questions that rose to my lips and wait for some more convenient season—if I might meet with one—at Rael's suggestion that we should go forward to meet Omra.
Such was my introduction to the method my newly-found instructor intended to pursue.
My companion seemed disinclined for further conversation as we leisurely passed along the Court, nor had I any regret to find him so. He had already said enough to give me food for thought, and my active mind was not slow to accept the opportunity of digesting it. I could not hope clearly and definitely to solve the mysterious problem of the second birth which had been so cryptically referred to, but in trying to review Rael's declaration in the light of my previous experiences and attainments, might I not prepare myself in some measure to anticipate something that was in process of revelation?
The whole environment was suggestive of contemplation. The atmosphere was fragrant with peace; the silence musical with rest; the soft light liquid with a sense of communion too deep to find expression in language. Why disturb it by any attempt to continue our conversation?
My mind again reverted to the condition in which I found and now had left Vaone—the langour and listlessness experienced by such as her as they reach that Valley of Content after battling and struggling through the earth conditions, and the desire they feel to rest their overwearied souls. For some reason I could not explain, in the mercy and by the grace of God, I had escaped this retaining influence, to all appearance, and when reaching what I have spoken of as the still water between life's ebb and flow, some benign current had carried me across the stagnancy into the rising flow of the eternal stream.
I hesitated, almost trembled, as I found myself arriving at such a conclusion, which appeared to be the only logical interpretation of my condition in the light of what Rael had said. Had he been more explicit about the second birth, I might have had more confidence; but did not his reference to its momentous nature warrant my surmise? Was I not conscious of an unfolding within me of new faculties, capacities and powers which appeared to be carrying me into some enchanted land of being which already thrilled me with a hyper-susceptibility to which I had been hitherto absolutely oblivious?
How I wished I were alone.
Rael caught my thought almost before I was conscious of it myself.
As he finished he turned away, and I had my wish.
It was a master-stroke on his part, to select the obvious lesson of the styles and colouring of the robes around us, as an illustration of the inability to understand the development I was experiencing. It was one of the first explanations I had heard after my arrival, that each colour bears its own significance, in their simplicity the darker denoting the lower and the lighter the higher conditions; but I had not yet been initiated into the meaning of the combinations and multiple variations which were represented around me. These denoted mysteries beyond my skill to fathom, they spoke of ranks and conditions of being, of which my comprehension had not at present heard, nor the heart of my imagination dreamed. They were suggestions of worlds of revelation lying deep within still unsuspected worlds to me, the beauties and glories of which would have blinded my vision with their radiance had not mine eyes been mercifully held that their light might fall as darkness on my virgin ignorance.
But though my untrained faculties were not able to appreciate all the subtilities of the majestic music that rolled around me, I was permitted to partake thereof to a rich overflowing of my soul's content. I was conscious of sweet and strengthening influences playing, around me; in the calm deaths of my being were echoes of music—if not actual voices – rhythmical and captivating sounds I hungered to hear more fully; from hidden depths within me shadowy angelic forms arose, crowned with an aureole of promise, beckoned me to follow, and I was saturated with a sense of life to which I was unable to find any satisfactory analogy.
How I longed to grasp and understand every detail and item of the overpowering experience, to master each separate feature in a lingering analysis until had I made the whole part of my very self. Vain, covetous desire! As well might I have attempted to single out a solitary voice in that grand chorus of the Magnetic Chorale and balance its effect. The parts were so beautifully adjusted and interblended with the whole, that it became an absolute unit, before which I bowed my head in reverent adoration, while the silence breathed its benediction of peace.
I could see no city—no wall—but the gate stood only a little distance away, and my feet were moving towards it. Were the influences and harmonies that were enthralling, enwrapping me, part of the accessories of the 'Welcome Home' those outcasts so confidently believed would await us there? Would their anticipation be realized after all? The possibility did not seem to be so incongruous now as once it appeared to be. Shall I find anyone there "watching and waiting for me?" What a question to ask. How could I expect it? I had been met, or rather found, on the slopes by Helen, but my mother was not there; and, in turn, I had come away and left her somewhere behind me, and probably should not know when she would reach the gate, and it was possible that I might not come to meet her. What had I done at any time – anywhere—to secure any such recognition? And yet had not Rael told me that even a greater than Myhanene—Omra—was even now on his way to meet me? Had not Rael gone away in order to meet him?
I should not only find someone waiting for me at the gate—it was evident they were not content to abide my coming till I arrived at the portal, but others than those I had known in the flesh were already on their way to give me welcome! There might be a readjustment in some details of the perspective—I had not found the gate to be standing on the margin of the river, as I had been promised, but it was evident that I had lost nothing in the rearrangement. How many times had I already discovered that God only delays in order to increase His blessings.
High life. the earnest of a higher!
Surely this must be a vibration from the storehouse of my memory. But I failed to trace it. Then I recalled the name by which Rael had spoken of the place, and, awestruck, marvelled at the thought of what might be before me.
Neither Rael nor Omra betrayed the slightest indication that they had as yet seen me, as they came in leisurely communion across the Court. I was somewhat relieved to find it so. since it gave me an opportunity of preparing to meet with one of whom, as I had told Rael, I felt a certain sense of awe, having only seen him in his official capacity at that baptism in the Sanctuary of Silence. My disquietude, however, proved to be groundless, as Rael had foretold me. Omra was another instance of the condescension in which greatness is lost in service. I only had to see him to desire his closer friendship—to recognize another Myhanene in him, at whose feet I would only be too happy to sit. In his figure and movement he was wonderfully like my better-known friend, but his simple pink robe spoke of another condition, as his light bronze complexion proclaimed another nationality.
They were drawing near, and still there was no visible sign of their knowledge of my presence, while I was wishing that more time had been at my disposal in which to study one to whom I was feeling an additional attraction at every step he took towards me; but that opportunity had now passed by.
"We can easily excuse you in that respect. Let it satisfy you to know that we do not expect—even when the presence of genius is assured—to find scientific accuracy in the infant during its birth-throes." Omra playfully returned with mystic reference to the second birth Rael had already spoken of.
Here Omra came to a deliberate pause upon which I was about to question him further, when he resumed, as if under the influence of an afterthought. "Man, the climax and crown of creation, as far as his physical nature is concerned, is a member of the animal kingdom. 'The Lord God formed (him) of the dust of the ground' (Gen. ii, 7), as a potter fashioneth his vessel from the clay, and of this physical part God afterwards declared "dust thou art and unto dust shalt thou return" (Gen. iii, 19). But our continued existence after our dust has returned to that from which it was taken, forms an object lesson as to the incapacity of the physical to adjudicate in the domain of the spirit. It is when the potter has formed his vessel that he employs it as a receptacle. So God, having formed man, said, 'Let us make him the receptacle of our own image,' and 'breathed into his nostrils the breath of life; and man became a living soul' (Gen. ii, 7). Thenceforward man is a physical vessel filled with a spiritual content—'there is a natural body and there is a spiritual body.' Now, while the foundation of the vessel is dust, which has to be wrought into shape by the hand and artifice of the potter before it is available for service, the germ of the soul is breath—invisible and intangible—which is enshrined in the secret place of the physical, to germinate and to be brought to the birth in the fulness of the appointed time.
"Of course, I am not unfamiliar with the idea of a second birth, but it has never been more to me than a verbal assent to it as to any other theological dogma," I replied, hoping to draw a yet further exposition.
"You are in no way peculiar in that respect," Omra responded. "Well spake the Master when He said, 'The kingdom of heaven is like unto treasure hidden in a field.' It is the same figure as I have spoken of—the spiritual treasure in the earthen vessel, and all the artifice and acumen of the earth is directed to uphold the authority of the flesh as being the teacher, rather than the servant, of the spirit. This necessitates the whole system of correction which you have seen established here, since it is an immutable law of the kingdom that 'there shall in no wise enter into it anything that defileth, neither whatsoever worketh abomination, or maketh a lie: but they which are written in the Lamb's Book of Life' (Rev. xxi, 27).
I had to be content to allow the mysticism of his concluding remarks to pass, and it was some time before I could trace therein an instance of the patient freedom they are willing to allow in the acceptance of an unapprehended truth. Omra was breaking new ground for me, and the force with which he accomplished it brought to my mind Paul's words: "The word of God is quick, and powerful, and sharper than any two-edged sword, piercing even to the dividing asunder of soul and spirit" (Heb. iv, 12); and like Moses on the mount, when he saw the lightning and heard the thunder and the trumpets, I said, "I exceedingly fear and quake" (Heb. xii, 21).
"How am I to know that I shall attain to such a consummation?" I presently enquired.
"And may I go on to know and understand this wonderful mystery?" I asked with returning confidence.
I had been so engrossed with Omra's conversation that I had not noticed that Rael had left us, until Omra indicated his wish for us to take a seat, and we threw ourselves on one of the fragrant divans near at hand.


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Lions go back-to-back
Yerington wins its second consecutive Division III volleyball state championship.
Lions go back-to-back Yerington wins its second consecutive Division III volleyball state championship. Check out this story on rgj.com: http://on.rgj.com/1t8DLUJ
Published 1:26 p.m. PT Nov. 20, 2014 | Updated 1:27 p.m. PT Nov. 20, 2014
Yerington High School players and coaches celebrate after being presented their state championship trophy after beating White Pine in the Division III title match Saturday.(Photo: Robert Perea/Mason Valley News)
Chloe Dane already had been part of two state championship teams, but as the Yerington High School volleyball team put the finishing touches on its second consecutive Division III state championship Saturday, she couldn't help but let the tears flow.
The Lions defeated White Pine 25-15, 26-24, 25-12 last Saturday in the Division III state championship match, after beating The Meadows 25-18, 26-24, 25-19 in a semifinal match Friday night.
It was the Lions' seventh state championship and fourth repeat title since 2006.
Dane has been a part of the last three of those, as a freshman in 2011 and a junior last season, but it was this one that meant the most. That's why she couldn't stop the tears as the team accepted the state championship trophy and their individual medals.
"Because it's my last year and being the only senior, I felt like I had a huge part in leading the team to this victory," she said.
Kassidy Lommori had 25 kills and five digs for the Lions in the title match, while Dane had 12 kills, 10 digs, and four aces and Jordan Bobrick had 15 digs and five kills.
"It's a lot more emotional because it's my last game, my last time playing with these girls, and I'm just so excited we could go out with a win," Dane said.
The Lions struggled at times against The Meadows, and overcame a lull in the second set in the title match, trailing by four points midway through the set and staving off set point by scoring the last three points.
"Yesterday was a rough game," Dane said. "We got all of our nerves out and today we just came out and played like we had all season."
Coach Debbie Rife said the Lions were motivated by the program's recent run of success and wanted to keep the legacy going.
"They want to come out and take care of it and do what we needed to do," she said. "And we just wanted to show it on the court and that's what they did."
Lommori said in addition to wanting to send Dane off with a championship, the Lions also wanted to win for Brianna Soukup, who was injured during the Division III North Region tournament the previous weekend.
"One of our best players got hurt last weekend and our other outside players stepped up and it was just the best feeling," Lommori said. "We worked hard and it got us to where we need to be."
Lommori said after struggling in the second set in Saturday's championship match, the Lions talked about finishing the match strong.
"We said let's just come out, don't get behind again, just finish strong," she said. "It feels great. Couldn't be happier."
Even though Yerington's football team was hosting a playoff game at the same time, the Lions had their usual large corps of supporters decked out in purple and white, and Rife said the win is for them
"The whole community comes out and supports us and that's what's awesome," Rife said.
Read or Share this story: http://on.rgj.com/1t8DLUJ
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Q: How to have indices of an array, except the elements, when we use n-choose-k? I would like to write an algorithm which gives an integer, and also an array, as input, and increases some elements. Assume that our array has 4 elements. Indices of selected elements which are going to be increased are as following (left hand integers are our algorithm input and right hand ones are the selected indices):
1 -> 1
2 -> 2
3 -> 3
4 -> 4
5 -> 1,2
6 -> 1,3
7 -> 1,4
8 -> 2,3
9 -> 2,4
10 -> 3,4
11 -> 1,2,3
12 -> 1,2,4
13 -> 1,3,4
14 -> 2,3,4
15 -> 1,2,3,4

Anyone knows how can I implement this algorithm in MATLAB?

A: I suspect by 'pointers' you mean the arrows of a clock, but that doesn't make it any clearer. What I get from your pattern is that you want the binomial coefficients, you can get them with the nchoosek function:
array=[1 2 3 4];
for k= 1:numel(array)
    b{k,1} = nchoosek(array,k);
end

A: I assume you can't generate all combinations at once (to save memory).
If you need to enumerate all combinations (so that each combination appears once) but you don't mind the order, you can:

*

*Increase a counter from 1 to 2^n-1, where n is the number of elements

*Obtain the binary representation of the counter

*Find digits equal to one in that representation.

Code:
n = 4;
for counter = 1:2^n-1
    comb = find((fliplr(dec2bin(counter,n))=='1'));
    disp([num2str(counter) ' -> ' num2str(comb)]);
end

Result:
1 -> 1
2 -> 2
3 -> 1  2
4 -> 3
5 -> 1  3
6 -> 2  3
7 -> 1  2  3
8 -> 4
9 -> 1  4
10 -> 2  4
11 -> 1  2  4
12 -> 3  4
13 -> 1  3  4
14 -> 2  3  4
15 -> 1  2  3  4

redpajama_set_name: RedPajamaStackExchange


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Film in Review: Atomic Blonde
Posted On September 13, 2017 By Editor
Dir: David Leitch
Cast: Charlize Theron, James McAvoy, John Goodman, Til Schweiger, Eddie Marson, Sofia Boutella & Toby Jones
The spy-thriller genre is often viewed as either over-the-top cheesy and rather unbelievable, as demonstrated in the older James Bond films, or else gratuitously action-packed to the point where there is almost no room for anything else, as seen in the Bourne series. David Leitch's Atomic Blonde attempts to inject a bit of life into a genre that can so easily become repetitive, and for the most part, he makes a solid effort.
Set during the fall of the Berlin wall in 1989, Atomic Blonde centres on MI6 killing-machine Lorraine Broughton (Charlize Theron), who is sent to Berlin to retrieve a valuable list of double agents after a fellow British agent winds up dead while carrying it. She is also tasked with murdering Satchel, a double-agent who is believed to have leaked information to Soviet agents. Lorraine enters a chaotic Berlin and, with the help of the shady and unreliable David Percival (James McAvoy) and seductive French beauty Delphine Lasalle (Sofia Boutella), she must navigate her way through a sea of double-crossers and Russian enemies.
Atomic Blonde does a lot of things right. The film is flashy in the best way, boasting striking colours and a banging soundtrack that hugely compliments the action-packed scenes. The fighting sequences are choreographed to perfection, with an excellent balance between slick editing and hide-behind-your-hands violence. The soundtrack, particularly the slowed-down version of 99 Luftballons played over the final sequence, adds just the right amount of whimsy to the film, stopping it from overflowing with gratuitous blood and gore, but allowing it to remain sleek. Visually the film is a joy to look it. Leitch makes fantastic use of vibrant colours and exciting contrasts. In fact, the white-blonde hair of Lorraine Broughton does an excellent job at intensifying the striking surroundings of the comic-esque world.
Charlize Theron proved herself as an action superstar in her acclaimed role as Furiosa in Mad Max: Fury Road (2015), and Atomic Blonde allows her to shut down anyone who may have doubted her ability. Her fighting is phenomenal and her performance as steely Broughton is as Cold as the War itself. Theron puts her male counterparts to shame, making use of everything and anything, from a hose to her own stiletto, to ensure her survival. Rocking one of the fiercest looks I've seen onscreen, Theron's performance keeps the film's tension ticking over, even though at no point do I fear for her losing a fight.
However, Atomic Blonde is not a flawless film. My biggest issue had to be runtime. For such a fast-paced film it began to feel quite drawn out towards the end, and the concurrent timeline of Broughton being interrogated seemed to detract from the film rather than enhance it. This ultimately delayed the ending and felt like two storylines needed to be wrapped up rather than one. For me, it felt like a niggling issue that had to be dealt with and, though the outcome was entertaining and in keeping with the film, made an otherwise exciting film seem that bit slower.
With the exception of Theron's portrayal of Lorraine Broughton, the character development in the film did not exactly grab me. James McAvoy's performance as Percival, though well done, was not dissimilar to other roles he's had in the past, and overall the air of shadiness about his character made the outcome of the plot a little predictable. The other characters are given little opportunity to shine. Sofia Boutella does well to convey the 'small fish in a big pond' idea of a young girl who got herself caught up in something way out of her depth, and her one-on-one scenes with Theron are quite standout in the film. Toby Jones and John Goodman have little to work with. Eddie Marson performs well and his role is key, however he feels like more of a prop to enhance the respective performance of Theron and McAvoy, and ultimately my attention was drawn to them over him.
Atomic Blonde is a battle between spectacle and story, and spectacle comes out on top. The film is visually powerful and makes fantastic use of a retro soundtrack that somehow still manages to give the movie a very modern vibe. This was matched with snappy, exciting editing and incredible fight sequences to make for a visual delight. Charlize Theron gave a stellar performance as icy blonde death-dealer Lorraine Broughton but ultimately the appearance of the film overshadowed the plot, which for me felt a little too drawn-out. Nonetheless, David Leitch's creation makes for an exciting, entertaining watch and definitely one for gals who are sick of watching men be the heroes.
Ciara Dillon – Film Editor
#Film & TV
Tagged: atomic blonde Charlize Theron david leitch spy
Finding the Perfect Scare – The Conjuring: The Devil Made Me Do It vs. A Quiet Place II
Film In Review: Black Panther
Posted On : March 27, 2018
Film Review: Once Upon A Time In Hollywood
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Singled Out: Diana Rein's Queen of My Castle
Blues rocker Diana Rein is gearing up to release her new album "Queen of My Castle" and to celebrate we asked her to tell us about the title song. Here is the story:
In the winter of 2017, a year had passed since I had written a handful of songs. I wanted to record them but I also wanted to write some new songs to create a more cohesive Blues vibe to my next album. I had already had a few meetings with Michael Leasure to start arranging the older songs and to start playing them together to see how they can be improved. This was before he came on board to be the Producer for the album. After seeing the direction the album was taking, I decided to take a few weeks to write new material that would fit right in with the blues and hopefully put our stamp on it.
I just remember sitting at my desk and showing up to write every day. I would record myself playing, as I usually do, with my computer's camera and my notebook handy. It's pretty rare that I ever start a song with lyrics. I usually always start with the rhythm guitar vibe first. But I had one lyric that just kept popping up. "You can call me a square babe, but I sure know how to roll." That little play on words amused me so I wanted to keep it. I jotted it down. Something about being square reminds me of just how square I was growing up. Always working to be the straight A student, valedictorian, over-achieving...I was a total nerd and I am proud of it. During college I became more relaxed but I still didn't lose the "square" completely.
During that time, the #metoo movement came into light as well and I really wanted to mold the song to have a more serious message for women. But I just wasn't quite feeling that the inherent vibe of that song was conducive to a serious message. So try as I might, it felt really contrived when I tried to make it more than what it was. I realized that this song had a very upbeat, playful energy. And all that I could think of was that women need to know their worth and be their own Queens. So instead of say being the Captain of My Own Ship, I made it to be the "Queen of My Castle."
When getting ready to shoot the video my husband and I had the idea of incorporating clips of Old Hollywood musicals and Actresses into the final video. But I came up against copyright issues. Since I didn't want to deal with that, I said screw it! I will just do it myself!! So I put my old nerd hat back on and I choreographed a dance, made sure I had some sparkles for some glam, grabbed my guitar and had a ton of fun. Sometimes you can empower others by just shining your light as bright as you can and being yourself. No matter what anyone says or thinks, your expression and creativity belongs to you. And when you know your Worth on top of that......you are sure to be the Queen of Your Castle.
Hearing is believing. Now that you know the story behind the song, listen for yourself and learn more about the album right here!
Singled Out: Diana Rein's Down Down Down
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Tiktaalik Fossil: Skull
This model shows the skull of Tiktaalik, a vertebrate that existed about 375 million years ago and had features of both fish and tetrapods (four-limbed animals).
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Tiktaalik Fossil: Body
This model shows the skeleton of Tiktaalik, a vertebrate that existed about 375 million years ago and had features of both fish and tetrapods (four-limbed animals).
Tiktaalik Fossil: Pectoral Fin
This model shows the pectoral fin bones of Tiktaalik, a vertebrate that existed about 375 million years ago and had features of both fish and tetrapods (four-limbed animals).
Tiktaalik Fossil: Pelvis
This model shows the pelvis of Tiktaalik, a vertebrate that existed about 375 million years ago and had features of both fish and tetrapods (four-limbed animals).
Tiktaalik Fossil: Humerus
This model shows the humerus bone of Tiktaalik, a vertebrate that existed about 375 million years ago and had features of both fish and tetrapods (four-limbed animals).
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February 1, 2018by editorNo CommentsCeltic Life
The Feast of Brigid
Imbolc, also known as the Feast of Brigid, celebrates the arrival of longer, warmer days and the early signs of spring on February 1.
It is one of the four major "fire" festivals (quarter days, referred to in Irish mythology from medieval Irish texts. The other three festivals on the old Irish calendar are Beltane, Lughnasadh, and Samhain – Halloween).
The word Imbolc means literally "in the belly" in the old Irish Neolithic language, referring to the pregnancy of ewes.
In ancient Irish mythology, Brigid was a fire goddess. Nowadays, her canonization is celebrated with a perpetual flame at her shrine in Kildare.
St. Brigid is the patron saint of babies, blacksmiths, boatmen, cattle farmers, children whose parents are not married, children whose mothers are mistreated by the children's fathers, Clan Douglas, dairymaids, dairy workers, fugitives, Ireland, Leinster, mariners, midwives, milkmaids, nuns, poets, the poor, poultry farmers, poultry raisers, printing presses, sailors, scholars, travelers, and watermen. Here's a busy saint!
One folk tradition that continues in some homes on St. Brigid's Day (or Imbolc) is that of the Brigid's Bed.
The girls and young, unmarried, women of the household or village create a corn dolly to represent Brigid, called the Brideog ("little Brigid" or "young Brigid"), adorning it with ribbons and baubles like shells or stones. They make a bed for the Brideog to lie in.
On St. Brigid's Eve (Jan 31), the girls and young women gather together in one house to stay up all night with the Brideog, and are later visited by all the young men of the community who must ask permission to enter the home, and then treat them and the corn dolly with respect.
Brigid is said to walk the earth on Imbolc eve. Before going to bed, each member of the household may leave a piece of clothing or strip of cloth outside for Brigid to bless. The head of the household will smother (or "smoor") the fire and rake the ashes smooth.
In the morning, they look for some kind of mark on the ashes, a sign that Brigid has passed that way in the night or morning. The clothes or strips of cloth are brought inside, and believed to now have powers of healing and protection.
The following day the girls carry the Brideog through the village or neighborhood, from house to house, where this representation of the saint/goddess is welcomed with great honor.
Adult women – those who are married or who run a household – stay home to welcome the Brigid procession, perhaps with an offering of coins or a snack. Since Brigid represents the light half of the year, and the power that will bring people from the dark season of winter into spring, her presence is very important at this time of year.
Neopagans of diverse traditions observe this holiday in a variety of ways, celebrating Brigid's divine femininity. As forms of neopaganism can be quite different and have very different origins, these representations can vary considerably despite the shared name.
Some celebrate in a manner as close as possible to how the ancient Celts are believed to have observed the festival, as well as how these customs have been maintained in the living Celtic cultures. Other neopagans observe the holiday with rituals taken from numerous other unrelated sources, Celtic cultures being only one of the sources used.
Imbolc is usually celebrated by modern Pagans on February 1 or 2 in the Northern Hemisphere, and August 1 or 2 in the Southern Hemisphere, or at the solar midpoint between the winter solstice and spring equinox, which now falls later in the first week or two of February.
The Closed Distilleries
Bretagne Soupe au Poisson


Laura is heading to Ryan's flat. It is their second date. Both are unsure as to how the evening will go, what they should do, what they shouldn't do. The anxiety and uncertainty are almost palpable. And the story begins. This comedy play is beautifully written by Rachel Hirons, Stef O'Driscoll directs Amy Butterworth as Laura and Thomas O'Connell as Ryan with aplomb and mixed with the video footage that is interspersed throughout the production makes this a late evening must see. The beauty for me is that everyone has been in the two principals position. Everyone has had the doubts and fears, so everyone can identify in the dilemma. Certainly the sell-out crowd in the show I saw were in accord with them. Sound comedy acting performances are delivered and make the characters totally believable and it is easy to empathise yet agonise at their reaction. I would thoroughly recommend this production to anyone who is looking for a genuine late night laugh, but don't delay, tickets I'm sure will be at a premium.


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The Witcher Season 2 is Confirmed? & When Will The New Season Premiere on Netflix?
After winning the hearts of the public with the First Season of The Witcher, Makers have decided to bring the Second Season also. The series has been telecasting on Netflix since the 1st Season. This is a Polish American fantasy drama which is based on Andrzej Sapkowski's works. The audience is willingly waiting to watch the next season of The Witcher. This fantasy drama series has been created by the one and only Lauren Schmidt Hissrich. The first season has been telecasted in 2019 and the season is being surmised to be released this year in 2021. The Witcher is starring Henry Cavill, Freya Allan, Eamon Farren, Anya Chalotra, Joey Batey, MyAnna Buring, Royce Pierreson, Mimi Ndiweni, Wilson Radjou-Pujalte, Anna Shaffer, and Mahesh Jadu.
Also Read: The Expanse Season 5 Release Date
The Witcher Season 2 is going to be released soon. The first season of The Witcher has got a huge hit and cherished more imaginations till December. The filmography of the show has been impeded due to hard pandemic time. But now the show is filming again. The first look of Geralt's new armour has been shared on social media in October 2020. The show is expected to be brought on the silver screen in the next year.
The Witcher Season 2 Release Date?
The Witcher Season 2 is scheduled to be in August 2021. The released date will be announced soon. Even on the subject of the release date, Lauren S. Hissrich stated through Reddit AMA, They do not have the target of the releasing date of The Witcher Season 2. There are so many expecting dates for releasing the series, but the exact date may only announce in 2021.
All the fans and the loving watcher of this series are wanting to return Henry Cavill back to this series. So guy as per the information he is coming back to this series again as Geralt. All cast of this much awaiting show has been revealed by the Netflix which is also including the new casts. The release date of The Witcher Season 2 has not been confirmed officially so far. As you know Cirilla is the prominent character in this series who often creates a splash on the silver screens.
According to the information, the three witchers whose name are:- Lambert whose play is being done by Paul Bullion, Yasen Atour is essaying the role of Coen, and The third new cast is Joel Adrian who is playing the role of Henrik. The previous cast, who are coming back to the next season 2 of The Witcher are:- Jaskier (Joey Batey), Triss (Anna Shaffer), and Cahir whose play will be done by Eamon Farren.