The other day I splurged on a beach ball from Wal Mart for the horses. Never did I have any idea how much fun it would be for them to target the beach ball nor how many training benefits would accrue.
Since both my mares are used to working together, I introduced it to both of them at the same time. When they first saw it rolling, they both scattered, of course. Meadowlark was the first to return to investigate it and earn a click. Serena was soon right next to her.
The first few times I lifted the ball up and rolled it away, they both acted a bit spooky. But, in no time at all I had two horses crowding around me before I could even get it out of my hands. Not wanting to get in the middle of two mares in excited competition, I quickly added another step into the training.
Both mares were clicked for targeting the ball with their nose and then they had to back up two steps and stay there until I rolled the ball away. I would cue them to "touch" and off they would trot to the ball.
Serena is usually taciturn and can be almost lethargic but she was trotting briskly after the ball. Meadowlark is Appendix Thoroughbred so she was off to the races in no time. My job was to stay safely aside until they had reached the target and touched it. I would click from a distance and then treat them as they stood quietly waiting for their reward.
Now to the benefits. Both of my mares have been struggling with different body issues that requires me to restrict the amount of lunging they do. Circle work is restricted, especially smaller circles, so I have been scratching my head for a way to exercise them that wasn't exhausting for me and injurious to them. Meadowlark isn't being ridden currently and Serena's spinal cord injury/past problem still restricts her riding tolerance. She is only ridden for short times at the walk.
I have discovered that working with the beach wall is a wonderful way to gently warm the horses up at the walk and then introduce slow trotting. They get exercise but without aggravating body issues that can be stirred up by too many circles. They also get lots of transitions. Since they are accustomed to working politely together, I can exercise them both at the same time when I am short on time and energy.
Meadowlark is practicing her ability to be energetic yet stay calm and polite when targeting the ball. I have tried teaching her trotting in hand in the past but we haven't perfected that yet. She seemed to considered my running along side of her as a sign that the herd was in trouble and she needed to leave fast. If I insisted she slow down through the lead she would pin her ears and make unhappy faces at me for asking her to go forward and then immediately asking her to slow down.
The beach ball gives a wonderful interim training step between her free lunging and trotting in hand. Tonight she was trotting out but also staying aware of my position and remaining polite throughout. Since she was heading to the target off lead, I could allow her to get a bit ahead and not have to ask her to slow down. Some of the time we practice walking to the ball together as well. Towards the end we were getting a steadier trot in which I could keep up but she didn't feel crowded and pressured. I was delighted to discover targeting the ball was an ideal training medium that can eventually lead to trotting in hand on a lead rope.
For those people who are dealing with horses that are so used to staying glued to their side that they can't get them to "go forward" out ahead, targeting a ball will teach them that they can work out ahead of you or leave you and still earn a treat. I balance the ball work with leading exercises to ensure we maintain our past lessons about matching my pace when I request it.
Meadowlark is improving each year but she has tended to be a reactive, sensitive mare. As a youngster she was spooky and would bolt without apparent warning, if something alarmed her. I was thrilled tonight when we took targeting the ball to a new level. By the end of the evening, I could stand next to her head, kick the ball into the air so it went at least 15 feet high and landed on the other side of the arena. I would then release Meadowlark and she would trot after the ball, trying to target it with her nose before it could even stop rolling. She didn't bat an eye when I kicked the ball vigorously throughout the arena and wasn't the least worried to see it flying through the air. A new version of sacking out to play with! I was so thrilled as tonight's exercise was something that would have sent her in full flight in the opposite direction not that long ago.
I admit I have been slow to come to trick training and "horse toys" as there were so many "manners" and foundation behaviors that needed to be established first, especially with Meadowlark. And I think I was wise to get her emotionally stable and thoroughly familiar with the clicker game first so we can now play in a safe manner. I had to work a long time on teaching her patience, calmness and tolerance for standing still. Now we get to mix it up a bit with exuberance and energy.
Now we are literally having a ball working a bit into the other end of the energy spectrum while maintaining manners and respect of space. Besides all these wonderful educational and exercise benefits, all three of us are having a lot of fun.
1) Introduce the ball. Have it sitting still and encourage the horse to approach it. Click if they reach forward to sniff it or touch it.
Repeat as many times as necessary until the horse is clearly comfortable with touching the ball and understands that it will be clicked for touching the ball with its nose.
2) Roll the ball forward a few inches. My horses know what the word "touch" means. If I cue them to touch, they will look for the nearest object to touch with their nose. You don't have to introduce a verbal cue now or at all, as long as your horse clearly has the idea of moving towards the ball and touching it.
3) Gradually extend out the distance you roll the ball, making sure that the horse is highly successful at each step so it doesn't get confused or give up. The more time you spend on getting each component solid, the more reliable the final behavior of chasing the ball.
4) At least with my horses, once they knew they were to follow the ball or go to the ball, they rapidly became enthused about chasing it.
We started with a very low level of energy and only accelerated the pace when they were clearly comfortable with the ball's motion and were eager to follow it. A lot will depend on your own horse's prior training experiences which is why I was pretty vague in specific details in my original post.
My horses have already been trained to go forward to stationary targets without me so the only new element for them was the idea of going to a moving target.
Also, you will need to see how skittish the horse is about the ball, especially the ball rolling. Some horses have been trained to stand still and ignore strange objects. In this case, you will need to increment the distance very slowly and encourage the horse to move forward to target the ball.
5) Get the behavior solid at a walk before working on speed. My horses were used to walking with me at liberty so initially I walked with them to the ball, after I rolled it. As they became more enthused they gradually went on ahead. I think when I started the horses trotting to the ball, I trotted with them so they knew they had permission to go faster.
6) If your horse is not used to working at liberty, you may want to start this on a lead rope. Safety always comes first. If you see your horse getting exuberant in a way that makes you feel uneasy, definitely do the initial training in hand and slow down the pace.
If I saw any rudeness between my mares or towards me, I stopped the game and left the arena for a few minutes. I only had to leave once when Meadowlark tried to warn Serena off from the ball. Both horses have been well mannered since. You are the best judge of your horse and its level of training in this area.
7) The behavior of "step back and stay back until I roll the ball" became necessary once the horses were so eager to chase the ball that they weren't willing to wait for me to roll it. Essentially they were mugging the ball to earn a treat faster and so they were starting to crowd into my space. I immediately set up the rule of them staying back and rewarded it each time initially so they didn't feel teased or punished by my withholding the ball. In time, they learned to stay back without me physically walking them back.
In order to ensure calm, control and safety, I simply took the horses by the halter, dropped the ball and backed them up a few steps. I clicked and treated for their backing. Once they know they will get reliably treated for backing as well as going forward and for staying back, they are happy to be polite. They are interested in getting the maximum number of treats in the shortest possible time and they don't particularly care what order they have to do things in, as long as requests are consistent and predictable.
Please note that my horses were trained to back on cue, to stand stay at liberty and to go forward or touch on cue. So I was simply shuffling several very well trained behaviors. Since they had a rich "vocabulary" of trained behaviors, it only took 3 sessions to achieve the final behavior.
Establish the rules for safety first, before you introduce an activity in which the horse will work at liberty and especially before you work at liberty in high energy. It is a great joy when you get to that point!
I hope all of my details and cautions are not daunting. Once you have an idea of what behavior you want to end up with, it is simply a matter of starting with the introduction of the ball and let the horse's response dictate what are the next essential steps.
Let this be a fun and safe learning experience for you and the horse. Take as long as it takes at each step of the way and enjoy the journey.
I hope you have a lot of fun with this. It is good exercise for the trainer too!


Flaxseed: A Superfood to Reign in Health & Fitness With!
Flaxseed is a powerful superfood that many people are still unfamiliar with. I was showing some pictures of me making my raw flaxseed crackers on facebook and someone asked me what was flaxseed and it's benefits. So here is a brief introduction!
Flaxseeds are made from the plant Flax and is also called linseed. 50% of the fat in flax seeds is omega 3 fatty acid. Flaxseed is the richest source of omega 3 fatty acids in plants making it a prime super food for vegetarians (vegans) who don't eat fish.
Whole flaxseeds should be stored in a cool dark place and are good for up to 12 months. For ground (milled, flaxmeal), it is optimal to store in the freezer. Whole seeds last longer than ground because the oxidation process begins when the seed is broken or ground. Flaxseeds are better that flax oil simply because you get the benefits of the entire seed and not just in part when you consume only the oil. Although flax oil is good, flaxseed is better!
How much do I need to see the benefits?
The optimum dose to obtain health benefits is not yet known. But 1-2 tablespoons of ground flaxseed a day is currently the suggested dose, according to the Flax Council of Canada.
Every time you have a certain food, like oatmeal, smoothies, soup, or yogurt, stir in a couple tablespoons of ground flaxseed. Flaxseed can be added to sauces, stews, soups, etc.
You can bake with it, muffins, breads, bagels, pancakes and waffles. Try substituting a portion of ground flaxseed meal for your flour. A suggested ratio is replacing1/4 to 1 cup of flaxseed meal when the recipe calls for at least 2 cups of flour.
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text:
Q: How to set up Firebase location as a Backbone Model ID? I use BackFire - Firebase integration with Backbone.js
Examining BackFire demo application I see that Firebase location is set as "root" key and as a value for ID key.
JSON response from Firebase

 {
  "-It-MYaWEFBI1QGD8PXB":
    {
     "title":dummy title",
     "id": "-It-MYaWEFBI1QGD8PXB"
    }
 }

In Model I see that Firebase location is set as Model ID.
Backbone Model attributes

attributes: {
  id: '-IswDV_2rwZu3WHO0giQ'
  title: 'dummy title'
},
id : '-IswDV_2rwZu3WHO0giQ'

I wonder how does data structure look like in Firebase Forge (backend) which creates response described above?

A: By going to the TODO page and typing in this command:
new Firebase('https://backbone.firebaseio.com').once('value', function(ss) {
console.log(JSON.stringify(ss.val(), null, 2))});

I am able to see the data structure looks like this:
{
  "-It-MYaWEFBI1QGD8PXB": {
    "id": "-It-MYaWEFBI1QGD8PXB",
    "title": "prepare lunch"
  },
  "-It-Mch8_bA23vkwAbUZ": {
    "id": "-It-Mch8_bA23vkwAbUZ",
    "title": "install Linux"
  }
}

So basically, because it's a demo, Anant has obeyed KISS and put the todo items at the root level. In a sophisticated application, you'd need to have more nesting and depth, of course.

redpajama_set_name: RedPajamaStackExchange


Jewish flags.  What if Jesus should claim to be the heir of King David?
decision to arrest Jesus had in fact been made several months earlier.
Passover.  This discussion ended abruptly on Palm Sunday.
patience, and might lead to direct occupation by Roman legions.
vipers, whitewashed tombs, and devourers of widow's houses.
were many reasons for dealing with Jesus.


text:
Ancient Symbols of Power: Royal Egyptian Rock Art of Nag el-Hamdulab Depict Rule of State and Military Might
http://www.ancient-origins.net/news-history-archaeology/ancient-symbols-power-royal-egyptian-rock-art-nag-el-hamdulab-depict-rule-020619
13 November, 2015 - 14:35 lizleafloor
An ancient king—heralded by standard bearers and trailing a retinue of soldiers, fan bearers, powerful beasts and deities—projects power and military might in elaborate scenes carved into the very rock in the Egyptian desert.
Rock art tableaux at the ancient site of Nag el-Hamdulab, created some 5000 years ago, are thought to have been done by the hands of professional artists close to the royal court. They are the earliest known depictions of a pharaoh wearing the "white crown" of dynastic power, and they represent the transition between pre-Dynastic Egypt's religious processions into the tax-collecting tour of a triumphant monarch.
Interpreted and presented for the first time by an international team of experts in the journal Antiquity, the "most important iconographic source for the period of state formation in Egypt" is revealed through symbols of power and ritual across seven sites on the west bank of the Nile.
Boat petroglyphs from Nag el-Hamdulab, Egypt. Credit: University College London
Study authors Stan Hendrickx, John Coleman Darnell, and Maria Carmela Gatto explore the historical significance of the rock art gallery at the sandy site, west of Nag el-Hamdulab village, about six kilometers (3.7 miles) north of Aswan, in Egypt.
Hendrickx, Darnell and Gatto date the creation of the images to a time just before Narmer, unifier of Egypt and founder of the First Dynasty.
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The Narmer Palette, dating from about the 31st century BC, contains some of the earliest hieroglyphic inscriptions ever found. It depicts the unification of Upper and Lower Egypt under the king Narmer. He holds a mace and wears the White Crown, as seen in the petroglyphs at Nag el-Hamdulab. (Public Domain)
The Discovery of Lost Symbols in the Desert
British Assyriologist and linguist, Archibald H. Sayce stumbled upon some of the rock art in the early 1890s, and recorded his find through simple drawings. The sketches and the rocks themselves would not be examined again for over a century, until 2008, when the site was rediscovered by archaeologists. The old sketches and the newly identified tableaux—seven in all, forming an ancient gallery of scenes—when brought together presented a unique record of a royal celebration and tax collection dating between 3200 and 3100 BC.
Hieroglyphic texts beneath the carefully pecked images explain the intent of the scenes. John Coleman Darnell, director of the Yale Egyptological Institute in Egypt, and professor of Egyptology told YaleNews that the Nag el-Hamdulab cycle is significant as it's the first of such images with hieroglyphic annotation.
The team of international researchers, including Egyptologists and archaeologists from institutions in America, Europe and Egypt have used high-tech digital reconstruction to analyze the images and texts.
Showcasing a series of vignettes, the rock art inscriptions of Nag el-Hamdulab represent a cycle. Interpreting the images, archaeologists believe the scenes of hunting, animals, boats, warfare, soldiers, prisoners, and an anonymous king wearing the White Crown are highly symbolic.
Though the scenes have been heavily damaged within recent history, the styles and techniques of the artists are evident, and suggest to researchers that all the works were the creations of only one or two individuals, and that it was created with an overarching 'grand scheme', and was not added to, piecemeal, over time.
The Grand Scheme: The Power of the King
The seven independent scenes at Nag el-Hamdulab are highly symbolic, culminating in a final message of royal power in Egypt.
Antiquity reports that the scene at Site 1 is dominated by boats. Near several reed boats a figure wearing feathers lies prostrate—possibly a prisoner or a foreign ally. Three prisoners follow a boat (they're shown with their hands bound behind their backs and ropes around their necks.) It is the boats which symbolize power and military might, rather than humans.
Reed boats, among the oldest known types of boats, are depicted in ancient rock art in Egypt. ((WT-shared) Shoestring at wts wikivoyage Creative Commons)
Sites 2 through 5 are located very close to each other, nestled within cliffs at the center of the Nag el-Hamdulab plain.
The first tableaux has a military theme wherein bowmen and prisoners are seen next to a boat upon which two figures stand. The two elevated figures each hold a staff. Who they are or what they represent is unclear. A unique individual stands between bowmen. His arm is shown bent behind his back, and his other arm is "upturned before the chest, in a manner unlike any other representation at Nag el-Hamdulab." Before the boat stands a single bowman with a very large bow. Bows were symbols of power and could be found often in Egyptian art appearing by themselves without an archer.
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A typical pre-Dyanstic pot with a boat theme. (CC BY-SA 1.0)
The second tableaux at Site 2 shows boats with many oarsmen and oars. An ancient sickle-shaped boat has a unique element – it is decorated with a bull standard. The king wears the White Crown or hedjet, the tall crown of Upper Egypt. In front of the king a dog is seen, a canine deity related to hunting and warfare, and his name "Wepwawet" means "the opener of ways" meaning the choices of life or the paths to death and the underworld.
The White Crown, or hedjet, as worn by Osiris in this tomb depiction. (Public Domain)
Animals, Feasts and Sacrifices: The Dance of the Old Kingdom
Site 3 has been mostly destroyed, and is only available via archive photographs. In the two scenes at the site the presence of a boat forms a connection to the other locations, but the king here is portrayed as a powerful ruler, rather than a symbolic religious placeholder. A man leads a wild bull or calf, and this is followed by the image of a large knife, suggesting that these are sacrificial animals for offerings.
A feast is presented in the rock art at Site 4. The festival scene shows brewing, and a figure sitting and drinking. What is thought to be a Nubian figure (by his distinctive bow) is depicted as bigger, perhaps signifying an important presence of Nubians in the Aswan region during pre-Dynastic times, the study notes.
Site 5 is unfortunately heavily damaged, but an interesting depiction of a bull's head and a female dancer can be seen. The dancer sports a long braid, the end of which has an oval shape that is said to be a weighted ball or disc found in hairstyles of female dancers during the Old Kingdom, effectively dating the scene. The bull and dancer communicate the rituals of hunting, butchering, feasting, music and dance of the Old Kingdom.
A scene of cattle being controlled by humans and dogs is shown at Site 6. This isolated tableau in the south of Nag el-Hamdulab highlights both wild and domesticated animals. The researchers note that hunting was important iconography of the pre-Dynastic era; it was part of an elite lifestyle and done not necessarily for survival, but for important festivals or burials. The hunting scenes are said to represent the wealth of local, likely Nubian, cattle-herding groups.
A Culmination: The Divine King Brings Order to Chaos
Site 7 is believed to be the most important of the series, the culmination of the cycle. Composed of four tableaux, one the largest of them all, the pecked rock images depict many boats in a row, with one notably higher than the others. An obvious ruler figure is followed by a fan bearer, and is preceded by standard bearers and a canine. This king figure stands on a decorated cabin, wears the White Crown, and holds a scepter. He is flanked by standards of falcons and bull horns, royal symbols. A shrine, or divine boat, is seen below this, lending the scene a religious context. Four bearded men tow the divine boat with a rope. The ritual procession is under the supervision of the king, and represents royal power.
Other scenes portray groups of animals—real and mythological—such as dogs, lions, ostriches, ibex, and animals whose heads radiate strange lines.
Narmer in a procession with standard bearers, falcons, on detail of the Narmer Palette. (CC BY-SA 3.0)
Antiquity writes, "The ultimate meaning of the tableau is the royal, human assurance of control, the triumph of order over chaos on a cosmic level, referring eventually also to regeneration. The link between site 7 and those previously described is not only made by the royal image, the boats, and the concept of ritual processions, but also by a small—and unfortunately poorly preserved—hunting scene close to the royal boat procession."
Early Dynastic usage of the White crown as seen in a detail of the Narmer Palette of Pharaoh Narmer. (CC BY-SA 3.0)
In all, researchers believe these rare panels are meant to highlight and extol the power of the first Egyptian pharaohs and their grand tax collection tours. Symbolic images drive home the royal domination over humans and a chaotic natural world. This ensemble sheds light on very early state formation in Egypt.
Featured image: A pecked petroglyph of a reed boat I the Nag el-Hamdulab cycle in Egypt. Credit: Stan Hendrickx, John Coleman Darnell & Maria Carmela Gatto
By: Liz Leafloor
Stan Hendrickx, John Coleman Darnell and Maria Carmela Gatto (2012). The earliest representations of royal power in Egypt: the rock drawings of Nag el-Hamdulab (Aswan). Antiquity, 86, pp 1068-1083 doi:10.1017/S0003598X00048250
Antiquity / Volume 86 / Issue 334 / January 2012, pp 1068 - 1083 DOI: 10.1017/S0003598X00048250, Published online: 02 January 20
Baker, Dorie. "Earliest Image of Egyptian Ruler Wearing "White Crown" of Royalty Brought to Light" 2011. News.Yale.edu [Online] Available here.
Gatto, Maria C. "The Aswan area at the dawn of Egyptian history". 2015. Academia.edu [Online/PDF] Available here: http://www.academia.edu/327900/The_Aswan_area_at_the_dawn_of_Egyptian_history
Watson, Ethan. "Rise of Civilization: Review of Research of Nag el-Hamdulab Rock Art Panels". 2013. NationalGeographic.com [Online] Available here.
Watrall, Ethan. Michigan State University. "Pictures: Oldest Pharaoh Rock Art Rediscovered in Egypt". 2012. Anthropology.msu.edu [Online] Available here.
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redpajama_set_name: RedPajamaCommonCrawl


text:
Design & Development BBDO
Theodore Asprogerakas-Grivas
Theodore Asprogerakas - Grivas is Managing Partner of the firm.
He is a full member of the Athens Bar Association as Attorney to the Supreme Court and a criminal law expert.
He provides legal consultation and representation on all criminal law matters with a further specialization on economic criminal law.
He practices active criminal law litigation on high-profile criminal cases before national Courts, the Supreme Court and the Court of State. He regularly represents similar cases before the European Courts and the European Court of Human Rights.
He has written and published several monographs and articles, mainly on criminal law topics but also on other fields of law.
He is a regular lecturer in seminars, conferences, institutions, academic fora and bodies in Greece and abroad.
He is an active full member of many prestigious Legal Societies, such as the Hellenic Society of Criminal Law, the Society of Greek Criminal Lawyers, the Hellenic Society for Legislation, the Association Littéraire et Artistique Internationale, the Society of Administrative Studies and others. In April 2022 he was elected Vice-President of the BoD of the Hellenic Society of Philosophical and Historical Research of Law and member of the BoD of the Société Hellénique d' Informatique Juridique et de Cybernétique du Droit.
He holds two Postgraduate Diplomas and a Master of Arts Degree, both from King's College London.
e-mail: asprogerakas@asprogerakas.gr
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It's April 25th, 2019, 5:37 am.
Real took the lead on 15 minutes thanks to Casemiro's opener but parity did not last long as Antoine Griezmann levelled things up 10 minutes later. Sergio Ramos then put the visitors back in front two minutes before the break after converting from the penalty spot.
And substitute Gareth Bale rounded things off 16 minutes from time before Thomas Partey was dismissed for picking up two bookings.
Now atletico hope of catching Barca is truncated.


text:
title := MinimumSizeSubarraySum
all: $(title).class

$(title).class: *.java
	javac *.java

again:
	javac *.java

edit:
	emacs $(title).java

run: $(title).class
	java $(title)

redpajama_set_name: RedPajamaGithub


text:
Position ID: UofT-Statistical Sciences-ASSISBIO [#14922, STA17#1]
Position Title: Assistant Professor, Statistics and Biosciences
Subject Areas: Biostatistics
The Department of Statistical Sciences in the Faculty of Arts and Science at the University of Toronto invites applications for a full-time tenure stream position in Statistics with applications in the area of Biosciences. The appointment will be at the rank of Assistant Professor and will commence on July 1, 2020 or shortly thereafter.
We are interested in candidates with research interests in one or several of statistical genetics and genomics, electronic health records (EHR), population health, multi-omic analysis and methods and data integration, whose research and teaching interests complement and strengthen our existing departmental strengths https://www.statistics.utoronto.ca/research .
Applicants must have earned a PhD degree in Statistics, Biostatistics or a related area by the time of appointment, or shortly thereafter, with a demonstrated record of excellence in research and teaching. Excellence in research is evidenced primarily the quality of published or forthcoming papers in top ranked and field-relevant academic journals, the submitted research statement, presentations at conferences, research awards and accolades, and strong endorsements by referees of top international stature. Evidence for excellence in teaching is based on strong letters of reference, teaching accomplishments and a teaching dossier containing a strong statement of teaching philosophy, teaching evaluations and sample syllabi.
The University of Toronto is an international leader in statistical science research and education. The successful candidate will be expected to conduct outstanding independent, innovative research at the highest international level; to establish a strong competitive externally funded independent research program; to demonstrate a strong commitment to undergraduate and graduate teaching, and to contribute to the enrichment of the department. The successful candidate will join a vibrant intellectual community of world-class scholars at Canada's leading university. The Greater Toronto Area offers amazing cultural and demographic diversity and one of the highest standards of living in the world.
Applicants are to apply online at AcademicJobsOnline and submit a cover letter; a current curriculum vitae; a list of publications; a research statement outlining current and future research interests; a recent writing sample (of no more than 15 pages); and a teaching dossier to include a teaching statement, sample course syllabi, and teaching evaluations. Applicants must also arrange to have at least three letters of reference (on letterhead and signed) uploaded through AcademicJobsOnline directly by the writers.
All application materials, including signed reference letters, must be received by November 25, 2019.
For more information about the Department of Statistical Sciences please visit our websites at https://www.statistics.utoronto.ca or contact Katrina Mintis, Department of Statistical Sciences at katrina.mintis@utoronto.ca.
Presentation List


This series will discuss how to seek after God's will for your life. You haven't finished your life story. What will you do with the blank pages? The choices you make today will lead you one way or another—but when you know who to trust, you'll always be headed in the Divine Direction.


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Home / News / Treatment & Doctors
Genetically Altered Adenovirus May Increase Efficiency of First-Line Chemotherapy
Treatment & Doctors
Written by Faith Franz
Franz, F. (2020, October 16). Genetically Altered Adenovirus May Increase Efficiency of First-Line Chemotherapy. Asbestos.com. Retrieved January 29, 2023, from https://www.asbestos.com/news/2012/11/26/adenovirus-chemotherapy/
Franz, Faith. "Genetically Altered Adenovirus May Increase Efficiency of First-Line Chemotherapy." Asbestos.com, 16 Oct 2020, https://www.asbestos.com/news/2012/11/26/adenovirus-chemotherapy/.
Franz, Faith. "Genetically Altered Adenovirus May Increase Efficiency of First-Line Chemotherapy." Asbestos.com. Last modified October 16, 2020. https://www.asbestos.com/news/2012/11/26/adenovirus-chemotherapy/.
In cancer treatment, oncologists often use certain compounds to make chemotherapy drugs more effective against malignant cells. These compounds are said to increase the cytotoxicity of the medication.
Researchers have identified several of these compounds for various mesothelioma drugs. These include the COX-2 inhibitor, which makes pemetrexed more effective, and HMBA, which increases the potency of doxorubicin.
An article in the December 2012 issue of the Journal of Thoracic Oncology discussed another such compound, known as E1B-ff kD-defective adenovirus.
In laboratory tests, this genetically altered adenovirus produced encouraging anti-tumor effects with both cisplatin and pemetrexed. Animal studies also recorded positive results in subjects who received the altered adenovirus/cisplatin combination.
E1B-ff kD-Defective Adenovirus
In its original form, the adenovirus can cause respiratory illnesses such as conjunctivitis and tonsillitis. Without the E1B-ff kD gene, however, the virus is not able to trigger these diseases.
The E1B-ff kD-defective adenovirus is a type of oncolytic virus. In layman's terms, this means that it is a virus that researchers have specifically engineered to play a role in cancer treatment.
The E1B-ff kD-deficient version of the adenovirus is also referred to as Ad-delE1B55.
Oncology researchers have focused on the adenovirus for more than a decade. This virus can selectively infect and reproduce in tumor cells, making it an ideal agent for gene therapy.
This type of therapy treats mesothelioma by replacing genes that became defective during the development of the cancer. Because mutated genes can allow cancerous cells to grow uncontrollably, gene therapy focuses on replacing the damaged genes with a healthy copy. Viruses – such as the adenovirus – are their preferred method of manipulating their target genes.
Most medical professionals regard gene therapy as less toxic to healthy cells than chemotherapy. However, when used in combination with chemotherapy, gene therapy may provide even more promising results.
E1B-ff kD-Defective Adenovirus in Mesothelioma Gene Therapy
When used with first-line mesothelioma chemotherapy, researchers believe the E1B-ff kD-defective adenovirus may be a potential therapeutic method for treating mesothelioma.
The study found that the E1b-ff kD-defective adenovirus was able to activate the p53 tumor suppressor gene. This gene is commonly mutated in mesothelioma patients, and some versions of the gene are associated with a higher risk of cancer susceptibility.
Mesothelioma cells that were infected with the altered adenovirus also displayed higher-than-normal chromosome levels. Cells that have these elevated chromosome levels (a condition known as hyperploidy) are especially susceptible to immune responses.
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Faith Franz
ffranz@asbestos.com
After graduating with an English degree from Southeastern University in 2010, Faith Franz came on board as a health and wellness writer for The Mesothelioma Center.
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In the Automotive Sector Deal the Government pledged £16m (subject to business case) for an industry led national supplier competitiveness and productivity improvement programme. It is intended that this improvement activity will be delivered by the NMCL Automotive Programme and led by SMMT.
The NMCL system includes a capability and competitiveness assessments and is supported by quality controlled improvement providers. Support to companies in the automotive supply chain can include training, coaching, mentoring and consultancy.
You are invited to declare an initial expression of interest in participating in NMCL Automotive by completing the following survey. Further information on the programme will be forwarded to you.


The Program is designed for special education students (ages 16-21) who will be transitioning from high school to independent living.Program staff will provide an authentic apartment living environment where students learn daily responsibilities, problem-solving, and decision-making skills.
Directions for contributing to this program.
See a list of community sponsors!


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Your Turn: July 15
Opinion // Letters to the Editor
Readers take Gov. Greg Abbott to task for two statements he's made recently: That migrants are creating "carnage" at the border — which PolitiFact has rated as false — and that drive-thru voting could open the door for "coercive effect."
Tamir Kalifa /Getty Images
More migrant myths
Re: "Abbott: Migrants causing 'carnage,'" PolitiFact, Metro, Monday:
Gov. Greg Abbott continues to pour mistruths on us — for example, his recent claim that "carnage is being caused by the people coming across the border."
Dictionaries generally define "carnage" as the slaughter of hundreds of people, as in wartime battles or military forces turning against their own people with massacres. No such events are occurring in Texas!
What has happened in much of Central America for decades, however, is carnage. That is why terrified people are at our border seeking asylum and safety. Abbott's disrespect for human suffering and dignity matches his shameless political posturing by promoting such mistruths. This includes the "Big Lie" about Donald Trump and the 2020 election. It's often hard to be a proud Texan these days.
Sally J. Andrade
Publicize policy
Re: "AG charges man who waited 6 hours to vote," Metro, Monday:
In the third-to-the-last paragraph in the story about Hervis Rogers, the real sad story is revealed: The number of credible cases of voter fraud is very small, with an outrageous amount of time and money spent "proving" them.
Rogers voted before his parole for a felony had expired. Wow! He did his civic duty but is being treated as if he had murdered someone. If people with felony convictions are not eligible to vote, it should be on the state to impress that fact on people who are released.
Christine M. Crowley
Slamming the brakes
I know "backseat drivers" can be a distraction, but I have never considered the problem they posed to voter integrity.
Thanks to Gov. Greg Abbott, I now see why "drive-thru voting" must end. As Abbott told Chris Wallace of Fox News on Sunday: "If you do drive-thru voting, are you going to have people in the car with you, and it could be somebody from your employer or somebody else who may have some coercive effect on the way you may cast a ballot?"
Wouldn't that be just like having my spouse join me in the voting booth?
Drive-thru voting must be ended to protect the sanctity of the ballot box! We're lucky to have a man of such great insight as our governor.
Carl Lloyd


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Recently my horizons have expanded. I am in no way a scholar of Japan or claim to be knowledgeable about Japanese culture, however, the narrative experimentation and craft of many of the following films fascinates me.
Imagine these are fragments from a film diary rather than reviews. I recommend the Criterion film essays that accompany many of these movies.
Double Suicide (1969), dir. Masahiro Shinoda, 10/10 (Masterpiece), IMDB link: The film starts in a modern puppet theater, the director discuss the scenes and the various theatrical styles. The historical drama unfolds, the puppeteers guide the human actors–who replace the puppets–and interact with their movements. Far from passive observers, the puppeteers watch in anguish as they cannot rewrite the plot as they are compelled to manipulate the characters towards their disasterous ends… This layer of artifice meshes with the thematic exploration of individuals who cannot escape from their societal constraints despite their incredible passions. Their anguish is our spectacle.
Pastoral Hide and Seek (variant title: Pastoral: To Die in the Country) (1974), dir. Shûji Terayama, 10/10 (Masterpiece), IMDB link: Japan's El Topo (1970) dir. Alejandro Jodorowsky? Shûji Terayama, a proponent of avant-garde theater (his troop acts in the film) weaves a poignant, personal, and surreal exploration of memory and time. The director as a young boy plays hide-and-seek in a cemetery with his friends, as he closes his eyes adults emerge from the tombstones. The film is his journey into his memories. Memories wild and metaphoric, relayed in surreal dreamlike visions across fraught fantasy-esque landscapes…. The film is color-coded, black and white, sepia-tinged, heightened color, each indicates a state of time–the circus and its timeless perambulations, the present, the memories of the past. His young self, but a projection of his present, is a ghost in his own past.
The Pornographers (1966), dir. Shôhei Imamura, 8/10 (Very Good), IMDB link: Imamura and his favorite themes, petty lowlifes and their lustful desires. All types of relationships and lusts, all observed from voyeuristic angles unfold. The pornographer lusts after his step-daughter, his mistress obsesses over the presence of her dead husband whom she believes is reincarnated as a carp that swims in a tank in her bedroom…. The camera peers through windows. The camera observes from the eyes of the fish. The pornographer feels his profession brings out repressed desires, none of which he questions or judges. The film is a psychological landscape with every obsession made manifest. Unlike a lot of Japanese film, the subject mater might be controversial but the Imamura never resorts to explicit sexual images—they are all left to our imagination.
Next on my watch list: Nagisa Ôshima's The Man Who Put His Will on Film (1970), The Ceremony (1971), and Diary of a Shinjuku Thief (1969) and perhaps Kei Kumai's Sandakan 8 (1974) although the subject matter will be tough to take.
I love the reincarnated husband fish!
It "jumps" (or the wife perceives it does) when something bad is about to happen… We observe all the scenes in her bedroom (with her new lover) from the perspective of the fish tank or, with the fish tank central to the scene. What a wonderful viewing experience….
Great to see that you have this interest as well. Have not seen the Oshima, am intrigued now.
Yes. old Japanese cinema is my favorite of all! Loved the Shinoda, not so sure about the Pornographers, did not "get" Pastoral. I am also thinking of blogging a aeries of posts on world cinema. Starting with Japan!
The Oshima film was definitely the weakest of the four. I suspect some of his earlier stuff (I list a few I want to watch at the very bottom — The Ceremony, etc) is more interesting. Ultimately it felt like a rather straightforward ghost story… He's famous for In the Realm of the Senses (1976) — which, you might know, is still banned in Japan.
I loved Oshima's Death by Hanging. So far, that is the only film of his that I have really liked. The Ceremony was pretty good but not exceptional, I thought.
Ha ha – I was posting about Death by Hanging at the same time you were! Yes, great film imo.
Thanks for this. Man oh man, my lists upon lists… all because of your awesome site. But: better to be busy than not!
No problem! I've seen a few more since this post… love the period.


As part of the wider movement for women's rights during the mid-1800s, women campaigned for admission to medical schools and the opportunity to learn and work alongside men in the professions. Such rights came slowly. Even after qualifying as physicians, women were often excluded from employment in medical schools, hospitals, clinics, and laboratories. To provide access to these opportunities, many among the first generation of women physicians established women's medical colleges or hospitals for women and children.
Persistence, ingenuity, and ability enabled women to advance into all areas of science and medicine. Courageously, they worked long and hard to succeed even where they were most unwelcome, such as in surgery and scientific research.
The first women to complete medical training and launch careers confronted daunting professional and social restrictions. To establish their rightful place as physicians and to expand opportunities for other women in medicine, they devised many strategies, establishing their own hospitals, schools, and professional societies. They excelled in their chosen fields of medical practice and scientific research-often while campaigning for political change and managing the administrative responsibilities and financial affairs of educational and medical institutions.
The first women of color who gained access to medical school confronted financial hardships, discrimination against women, and racism. For generations, their families had been enslaved or oppressed. They had been denied the means of making a living and access to decent medical care. Even to begin training, these women often had to work their way through medical school or seek funding from supporters of women's and minorities' rights.
Once they became doctors, these women played an important role in bringing better standards of care to their own communities and served as role models for other women.
By the early 1900s, women had made impressive inroads into the medical profession as physicians, but few had been encouraged to pursue careers as medical researchers. To succeed as scientists, despite opposition from male colleagues at leading institutions, women physicians persisted in gaining access to mentors, laboratory facilities, and research grants to build their careers.
The achievements of these innovators often went unrewarded or unacknowledged for years. Yet these resourceful researchers carved paths for other women to follow and eventually gained recognition for their contributions to medical science.


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Huang Tingjian (chinois 黃庭堅, EFEO Houang T'ing-kien, pinyin Huáng Tíngjiān), né en 1045 à Fenning de Hongzhou (actuelle Xiushui au Jianxi), mort en 1105 au Guangxi, est un écrivain et calligraphe chinois.

Son surnom (hao) est Shangu laoren, le Vieillard de Shangu.

Huang Tingjian obtient le grade de docteur en 1067. Politiquement proche de Su Shi, il est exilé à Fuzhou au Sichuan.

Poète renommé, Huang Tingjian est l'auteur de ci, forme dans laquelle il est toutefois inférieur à Su Shi, son contemporain auquel il est étroitement associé. Il est surtout remarquable pour ses poèmes réguliers (shi) et ses ballades. Ses préoccupations formelles font que sa poésie est difficile d'accès. Il est cependant un novateur, ayant eu une grande influence jusque sous la dynastie Ming.

Œuvre calligraphique

 Poème de Du Fu à He Lanxian, Pékin, musée du Palais
 北宋 黃庭堅 草書廉頗藺相如傳 卷 (Biographies de Lian Po et Lin Xiangru), New York, Metropolitan Museum of Art
 Scroll for Zhang Datong (Zeng Zhang Datong guwen ti ji), Princeton, Princeton University Art Museum

Le , l'une de ses calligraphies a été vendue 390 millions de yuans (environ 47 millions d'euros) lors d'une vente aux enchères.

Traductions
 Paul Demiéville, Anthologie de la poésie chinoise classique, Gallimard, « Poésie », Paris, 1962
 Jacques Pimpaneau, Anthologie de la littérature chinoise classique, Philippe Picquier, 2004

Références

Bibliographie
 David Palumbo-Liu, The Poetics of Appropriation : the Literary Theory and Practice of Huang Tingjian, Stanford University Press, 1993.
 Yugen Wang, Ten Thousand Scrolls. Reading and Writing in the Poetics of Huang Tingjian and the Late Northern Song, Harvard University Press, 2011.

Voir aussi

 Compilation complémentaire de la poésie ci de Shangu, sur le site de la Bibliothèque numérique mondiale

Écrivain chinois du XIe siècle
Poète chinois du XIe siècle
Poète chinois du XIIe siècle
Naissance en 1045
Décès en 1105
Calligraphe chinois du XIe siècle
Calligraphe chinois du XIIe siècle

redpajama_set_name: RedPajamaWikipedia


Hey, I'm Elizabeth. I hung up my nanny hat a while ago and now work full time for a very busy non-profit. I love hanging out with kids of all ages and am looking for some babysitting jobs to fill my spare time with. I have experience with newborns to teens -- my favorite kids activities are reading, puzzles, legos, hide and seek and baking.
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Getting this far took courage.
The rest of the way requires the right team.
We maximize results through a combination of individual, intensive outpatient, group, and family therapy.
We use multiple modes of treatment to get to the root of the condition.
If your insurance is not listed above, please call us to discuss your payment options.
Talk Therapy is a certified DHCS facility.
This California State certification is granted to programs that exceed minimum levels of service quality and are in substantial compliance with State program standards, specifically the Alcohol and/or Other Drug Certification Standards.


I loved this series and this last disc wraps it all up nicely in a last hoorah that ties up any loose ends as Jean and Lionel reminisce over all the good times and bad in the last thirty eight years. I thought that this was exceptionally well done and a fitting end to this great show.
Fans of the series would know as do I that what keeps us hooked on this is the human element that was so delightfully portrayed by Judi Dench and Geoffrey Palmer. They suited each other perfectly and the vibe that I felt was of one of mutual respect and the ability to get the best out of each other's performance.
There are many shows out there and I couldn't pretend that it's not often that a series like this comes around, however I could say that during it's time there were not many British shows hitting our shores that had what As Time Goes By did. And certainly nothing on the tele depicting as believable and genuine a relationship.
I recommend all viewers to this series and naturally enough those that came before it as if you were to start watching this series at the end you would be wasting your time! It's a great series and this DVD does a splendid job of wrapping it all up nicely.
Audio and visual present nothing at all to complain about. It's all good over here guv'nor.