Choice of direction. 3d person standing on red arrows with compass. 3d image. white background.
3D person standing on red arrows with compass. 3d image. White background.
3D little human character about to make a choice. Blue. People series.
3d Illustration of person and different directional arrows. 3d rendering of human character.
3d small person standing on red arrows. 3d image. Isolated white background.
Backward or forward opposite signs. Two opposite signs against blue sky background.
Choices and strategies symbol represented by a network of roads and highways merging to a center point showing many options and paths available to a team and common goals vision and a multiple paths to a unified strategy.
Arrow and question mark are shown in the picture.
Two people are choosing the direction of movement. 3d image. Isolated white background.
3d person sitting on a rock on a distinguished road. 3d image. Isolated white background.
3d person thinks that choose. 3d image. White background.
What to choose yes or no. 3d image. White background.
Man chooses a resting place on the globe. 3d image. White background.
The man is pointing the right direction. 3D image. White background.
The green arrow points to the top, a red down. 3d image. White background.
Two people at the crossroads. 3d image. White background.
Businessman moving up on the green arrow. 3d image. White background.
The compass indicates the direction of movement. 3d image. White background.
3d people and diagram of financial growth. 3d image. White background.
The team of businessmen promotes your business. 3d image. White background.
3D person is promoting the leader of the up arrow. 3d image. White background.
A green check mark in the center of the circle. 3d image. White background.


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Drosophila phalerata is a species of mushroom-feeding fruit fly in the Drosophila quinaria species group. The genome of D. phalerata was sequenced in 2019 as part of a study on the evolution of immune systems, but was not assembled de novo.

Unlike its sister species D. innubila, the anterior and posterior costal wing veins of D. phalerata show prominent melanin deposition (see gallery below). Drosophila quinaria species group flies including the related D. guttifera display marked variation in their wing patterning, and melanin synthesis and deposition has been used as an obvious and malleable trait to study the regulation of gene expression.

Gallery

References

External links

phalerata
Articles created by Qbugbot
Insects described in 1866

redpajama_set_name: RedPajamaWikipedia


Is the Wellcome Trust's decision not to go with the four-day week a setback for flexible working?
It was reported at the end of last week that the Wellcome Trust had decided not to go ahead with plans for a four-day week. The Trust is said to have looked into it and found a four-day week 'too operationally complex' to implement.
The initial reasons for doing a three-month study into the possibility of moving to a four-day week was employee well being and greater work life balance as well as potential improvements in productivity. However, the Trust is said to have found a compressed working week would be difficult to operate in some back room departments such as IT and HR and include stress.The decision not to go ahead with the four-day week is seen as a blow to those advocating reduced working weeks, including the Labour party, but the Wellcome Trust says it is still committed to finding ways to improve employee well being.
We have profiled employers who have moved to a four-day week on workingmums.co.uk. Most are smaller employers and have very specific ways of operating. For instance, Radioactive PR's move to a four-day week recognises that Fridays are light days in PR and that PR people already work on stand-by over weekends.
It's harder in larger organisations and each sector has its own demands. Some have criticised the four-day week as an example of inflexible flexible working, imposing four days instead of finding more flexible solutions that fit a particular individual, team or workplace.
But four-day weeks are popular. In recent years many women who would previously have reduced to three days a week are instead moving to four with a day or two a day of working from home. That makes the whole work life thing manageable.
What people want is more time for the non-work stuff and more time generally to recover from the ever-increasing intensity of the working week.
Workloads seem always to go up rather than down. In the media, there's more and more social media to keep on top of or feed, for instance. An extra tweet or two a day seems like nothing much extra, but then there is Instagram, replying to tweets usually more or less immediately, tagging the right people, monitoring other tweets and so on and so on. It all mounts up. And nothing else is usually taken off your workload.
That is why there need to be regular checks on workloads, regular discussions on what is and isn't possible, what is and isn't necessary. It's not enough to review and redesign jobs at the point of advertising them, though that is crucial. Jobs are changing all the time and workloads need to be realistic or people end up not caring so much, caring too much and risking burnout or leaving.
The clamour for a four-day week is just a symptom that people need more time to recover from the intensity of modern working lives. It coincides with increasing automation. Who knows what automation will bring – different reports suggest wildly different scenarios. If it could be used intelligently to free people up to do the elements of their jobs that only they can do it could be a positive.
I was trying to find contact details for a journalist the other day. I went on a newspaper's Facebook page. It boasted that it replied instantaneously to messages. Of course, it did. It was a bot. I asked it for the contact details of the newsdesk. Instantaneously it gave me the page which I had earlier looked at on the newspaper's website. A blank page. I asked again in different words. It did not understand. It started suggesting wilder and wilder options. In fact it was next to useless, like so many of those phone systems you get from internet companies and the like when your line goes down and you are basically desperate to talk to a human being to explain your problem.
On our site we get loads of questions from people about employment law. Like most questions, they are usually not straightforward because people's lives are not straightforward. They often have several caveats or different elements. A bot answer can only answer the simple stuff. That does alleviate some of the work a human might have to do, but it does not entirely replace a human. At least not yet. If that could be harnessed to benefit an exhausted workforce it could bring benefits – at least in the short term.


Queen Jacquelyn of Villeneuve is a benevolent ruler, a loving mother, a devoted wife, and a woman with a monstrous score to settle. Set more than a century before the events of Damsels, this gigantic one-shot tells the tale of one woman's quest for ultimate revenge. By sword, or by sorcery, all shall be slain.


text:
The battery for Onyx BOOX Vasco da Gama 3
In order to be sure that exactly this battery is installed in your e-book it is necessary to disassemble your device before ordering something. Some manufacturers of e-books install different batteries into different batches of the same model!
Attention: the authors are not responsible for disruptions of work of e-books got after using this information. Everything you do is on your risk! Using this method removes your e-book from the warranty!
In e-books Onyx BOOX Vasco da Gama 3 is installed the battery PH386888.
Parameters of the battery:
model: PH386888
capacity: 3000 mAh
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Battery for the Gmini Magic Book M61SHD
Arkady Strugatsky, Boris Strugatsky "Roadside Picnic". Red Schuhart is a stalker, one of those strange misfits who are compelled by some unknown force to venture illegally into the Zone and, in spite of the extreme danger, collect the mysterious artefacts that the alien visitors left scattered around. His life is dominated by the Zone and the thriving black market in the alien products. Even the nature of his daughter has been determined by the Zone. And it is for her that Red makes his last, tragic foray into the hazardous and hostile depths...
Sergey Dyachenko, Marina Dyachenko "The Scar". Reaching far beyond sword and sorcery, The Scar is a story of two people torn by disaster, their descent into despair, and their reemergence through love and courage. Sergey and Marina Dyachenko mix dramatic scenes with romance, action and wit, in a style both direct and lyrical. Written with a sure artistic hand, The Scar is the story of a man driven by his own feverish demons to find redemption and the woman who just might save him. Egert is a brash, confident member of the elite guards and an egotistical philanderer. But after he kills an innocent student in a duel, a mysterious man known as "The Wanderer" challenges Egert and slashes his face with his sword, leaving Egert with a scar that comes to symbolize his cowardice. Unable to end his suffering by his own hand, Egert embarks on an odyssey to undo the curse and the horrible damage he has caused, which can only be repaired by a painful journey down a long and harrowing path...
Cecelia Ahern "The Time of My Life". Lucy Silchester keeps receiving this strange appointment card and sweeping its gold embossed envelope under the rug. Literally. She busies herself with a job she doesn't like, helping out friends, fixing her car, feeding her cat, and devoting her time to her family's dramas. But Lucy is about to find out that this is one appointment she can't miss, when Life shows up at her door, in the form of a sloppy but determined man...

redpajama_set_name: RedPajamaCommonCrawl


text:
Rec. Grade Levels Archives: 9
When their mother is sentenced to 10 years in a Mexican prison on questionable charges, teenagers Rocío and Ale are left with no choice but to play the role of both mother and father to their two younger siblings. The Other Side of the Wall roots its timely story about dislocation and migration in a deeply intimate and emotional domestic drama.
For Akheem
Daje Shelton, a 17-year-old girl from St. Louis, just wants to do the right thing. But growing up in a tough neighborhood, she can't catch a break: she's struggling in school; she's distracted by boys; and she's surrounded by a culture of violence and brutality. The fatal shooting of Michael Brown Jr. provides a powerful backdrop for this masterfully crafted portrait of working-class urban life.
Young Tom Hall and his misfit friends fight to save "Buster" the baby elephant during the German air raid bombings of Belfast, Northern Ireland in 1941.
Life and Nothing More
A stunning fusion of drama and real-life, Florida-based director Esparza's remarkable second feature follows Regina, a single-mother, and her teenage son Andrew. As Regina brings another man into their lives, Andrew wrestles with young adulthood, first love, and his feelings about his absent father.
United Skates
A rousing tribute to roller-skating's pivotal role in the African-American community, United Skates careens around the country, offering an intimate look at a lively subculture that's under threat. Facing discriminatory policies and rink closures, committed skaters from around the country—including Chicago's own Buddy Love—fight to preserve a space for people to come together and express themselves in sliding, bouncing, snapping glory.


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Company: Nottingham Shakespeare Company
A tall tale of lost love, betrayal and redemption, spanning two kingdoms and 16 years. A story of kings and queens, princes and rogues, shepherds, prophecies . . . and a bear.
St Giles' Church, Nottingham 2 Feb 2023
St Peter's Church, Nottingham 3 Feb 2023
Southwell Minster, Southwell 4 Feb 2023


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CALCIUM DEPOSITS/TURNING TO STONE
Reprinted with permission from our Preferred Product Partner Life Extension
By William Faloon
As we age, our soft tissues harden as a result of calcium infiltration. This calcification process is a major contributor to degenerative disease. Vitamin K functions to keep calcium out of soft tissues. New findings reveal that a vitamin K deficit creates more vascular calcification than initially thought.
A recent study showed when women were given a drug that blocks vitamin K, there was a 50% greater prevalence of arterial calcification compared to women not taking this drug (warfarin). This pathological effect occurred in as little as one month.1 This study showed that longer term use of warfarin was associated with even greater arterial calcification prevalence.
Kidney dialysis patients suffer severe arterial calcification with cardiovascular disease accounting for almost half of all their deaths.2 A clinical study examined vitamin K levels in dialysis patients. The results showed that93% of the patients were at risk for arterial calcification. This risk was shown to be reduced with vitamin K2supplementation.3
The quotation below comes from a report published by the American Heart Association.4 Despite this indisputable data, doctors today typically do nothing to protect their aging patients from the devastating impact of vascular calcification.
This article briefly describes how proper use of vitamin K can markedly protect our soft tissues against calcification.
"Most individuals aged over 60 years have progressively enlarging deposits of calcium mineral in their major arteries.5 This vascular calcification reduces aortic and arterial elastance, which impairs cardiovascular hemodynamics, resulting in substantial morbidity and mortality6-8 in the form of hypertension, aortic stenosis, cardiac hypertrophy, myocardial and lower-limb ischemia, congestive heart failure, and compromised structural integrity.9-11 The severity and extent of mineralization reflect atherosclerotic plaque burden12 and strongly and independently predict cardiovascular morbidity and mortality."13
Source: American Heart Association
A search of the National Library of Medicine data base using the term "vascular calcification" at the time of this writing turns up the following numbers of published scientific articles:
Year New Articles
2014 700+
The total number of articles that discuss arterial calcification in the National Library of Medicine as of April, 2015, is over 6,400.
The surge from a mere 16 articles in 1982 to over 6,400 today is a reflection of the exponential increase in knowledge about this widespread pathological process.
The problem is that this lifesaving data is not being translated into clinical medical practice where it is urgently needed to protect aging humans against a host of cardio-vascular disorders.
Calcification And HypertensionWhen arteries are soft and elastic, they readily expand and contract with each heartbeat. As arteries harden (calcify) and lose youthful elasticity, there is a progressive elevation in blood pressure.14
This happens because the heart is forced to beat stronger to force blood into the increasingly rigid arterial system. Calcification of the large artery exiting the heart (the aorta) helps explain why blood pressure elevates as people age.
A hallmark sign of long-term hypertension is enlargement of the heart's left ventricle,15 which is the chamber of the heart that pushes blood into the aorta from where it is then distributed throughout the body.
The increase in cardiac workload caused by aortic rigidity (calcification) contributes to heart failure that afflicts over 5 million Americans.16,17
A dilemma faced by elderly persons is progressive dysfunction of the valve between their heart and aorta that opens and closes with each heartbeat.
When the aortic valve fails to completely close, blood regurgitates back into the left ventricle of the heart.18,19Without surgical replacement/repair of the aortic valve, death from congestive heart failure often occurs.20
Elderly persons are challenged to fully recover from aortic valve replacement, though newer intra-arterial techniques are becoming available whereby an artificial valve is threaded through the aorta and sewn into place.21 Those with successful mechanical valve replacements usually require anticoagulant drug therapy for life, which poses its own complicated set of side effects.22
It used to be thought that aortic stenosis was caused by a lifetime of "wear and tear."23 It is now clear that calcification of the aortic valve leaflets is a cause of aortic valve failure, along with chronic inflammation, elevated glucose, high homocysteine, and low magnesium.24-31
Coronary Artery Calcification
Blockage of the coronary arteries that feed the heart muscle necessitates enormous amounts of hospital expenditures each year in the form of open heart coronary bypass surgeries and intra-arterial "stenting" procedures.
Interestingly, when open heart surgery is performed to replace a calcified aortic valve, the surgeon will often also bypass blocked coronary arteries in the same patient.32 This is not surprising since coronary atherosclerosis and aortic valve stenosis have similar underlying causes such as elevated homocysteine, chronic inflammation, and calcification.33-36
Calcification plays a significant role in accelerating the formation of the atherosclerotic plaque that narrows the coronary arteries of aging humans. In patients with coronary artery disease, calcification is present in90% of cases.37,38
Clinically, vascular calcification is now accepted as a valuable predictor of coronary heart disease.39 Yet most cardiologists use it only as a diagnostic marker (the coronary calcium score test) as opposed to directly treating the underlying calcification pathology.40
What Causes Arteries To Calcify?
Many of the known risk factors that underlie atherosclerosis have been shown to promote arterial calcification. These include elevated LDL cholesterol, elevated homocysteine, diabetes, kidney failure, chronic inflammation, and oxidative stress.33,41-55
Additional calcification contributors include low magnesium (a natural calcium channel blocker), hormone imbalance, and excess blood calcium (caused by hyperparathyroidism).56-66
An underappreciated, major reason our vascular system turns to stone (calcifies) as we age, however, is inadequate intake of vitamin K.
As you'll read next, a low blood level of vitamin K2 causes a protein in the vascular wall to bind calcium to arteries, heart valves, and other soft tissues.
A Calcium Inhibitor In Need Of Vitamin KMatrix Gla-protein is a vitamin K-dependent protein, and it must be carboxylated to function properly. Poor vitamin K status leads to inactive uncarboxylated matrix Gla, which enables calcium to accumulate in soft tissues.67-69
Failure to optimally carboxylate matrix Gla-protein is a risk factor for atherosclerosis, coronary heart attack, and kidney disease.70-74 The title of a 2008 study that examined the impact of cardiovascular calcification is: "Matrix Gla-Protein: The Calcification Inhibitor In Need Of Vitamin K."75,76
Matrix Gla-protein lines our vascular system and its function is governed by the quantity of vitamin K in our bloodstream.
When vitamin K levels are less than optimal, matrix Gla-protein allows calcium to infiltrate into our soft tissues similar to the way calcium absorbs into bone. When you hear the term "hardening of the arteries," this can literally mean one's previously flexible blood vessels are turning into rigid (calcified) bony structures.
With optimal levels of vitamin K, matrix Gla-protein becomes activated to shield calcium from entering arteries, heart valves, and other soft tissues.
Said differently, vitamin K functions as a control switch. When matrix Gla-protein is turned "on" by vitamin K, itblocks calcium from entering soft tissues. In the absence of adequate vitamin K, the matrix Gla-proteinswitch is turned "off" and calcium quickly infiltrates into soft tissues.
So the title of the 2008 study is quite revealing in that matrix Gla-protein is clearly a " calcification inhibitor in need of vitamin K."
WHAT IS MATRIX GLA-PROTEIN?
Early forms of life emanated from calcium-rich oceans, which required primitive organisms to develop mechanisms to prevent widespread calcium crystallization of living soft tissues.77
A prominent calcium-blocking mechanism is through activation of a protein called matrix gamma-carboxyglutamic acid, more commonly referred to asmatrix Gla-protein or matrix Gla.78
The key to how matrix Gla-protein functions lies with its "carboxyl" group.Matrix Gla must be carboxylated to function properly.74
In the presence of vitamin K2, matrix Gla-protein becomes "carboxylated," which means it's being turned " on" to repel calcium infiltration.74
Insufficient vitamin K2 results in matrix Gla being inadequately carboxylated or turned "off," which means it's unable to inhibit calcium infiltration into soft tissues.
To keep our natural calcium inhibitor matrix Gla continuously carboxylated, we need to provide it with a steady supply of vitamin K2. This is easy to do with one-per-day dosing of the proper forms of vitamin K.
What Happens When Vitamin K Is Acutely Withdrawn?
A recent study provided real-world evidence of what happens to aging humans who are deprived of vitamin K.
Warfarin is an anticoagulant drug that functions by antagonizing the effects of vitamin K in the body.79 This drug has been sold under the trade name Coumadin® for many decades.
Scientists were long ago aware that warfarin users suffered accelerated arterial calcification, but until recently, there was no alternative to protect high-risk patients from a thrombotic (arterial clotting) event, such as an ischemic stroke.
A study published in 2015 evaluated 451 women using mammograms to measure arterialcalcification. After just one month or more of warfarin drug therapy, the prevalence of arterial calcification increased by an astounding50% compared to that in untreated women. When these women were evaluated again after five years, the prevalence of arterial calcification increased almost 3-fold.1
This new human trial provides stark evidence of rapid calcification occurring in response to vitamin K withdrawal caused by warfarin (a vitamin K antagonist drug.)
We discuss the pros and cons of anticoagulant drugs that may be used in place of warfarin in this month's issue of Life Extension® magazine.
What Happens When Vitamin K Is Introduced To Deficient Patients?Kidney failure patients are kept alive by thrice weekly dialysis treatments. While the advent of hemodialysis has added countless human life years, it produces devastating side effects over the longer term. Over 50% of hemodialysis patients have vascular calcification, a major cause of cardiovascular disease. Cardiovascular disease accounts for about 50% of all deaths in these patients.80-82
A study was done to evaluate the effects of varying doses of the MK-7 form of vitamin K2 on markers of arterial calcification including carboxylation (activation) of matrix Gla-proteins.83
MK-7 (menaquinone-7) is a unique form of vitamin K2 because it remains active in the body for 24 hours and longer.84
At baseline, hemodialysis patients had a 4.5-fold higher level of uncarboxylated matrix Gla compared to controls.83 Daily doses of MK-7 of 45 mcg, 135 mcg, and 360 mcg were then administered over a six-week period.
THREE FORMS OF VITAMIN K
Based on the totality of evidence and low cost, it is prudent to take a supplement that contains multiple forms of vitamin K. The three forms of vitamin K most applicable to human health are:
Vitamin K1 . Vitamin K1, also known as phylloquinone, is found in plants and some of it converts to vitamin K2 in the body.85 This form is considered the least effective because it depends on conversion into activated K2 to confer significant protection against calcification. There are nonetheless published studies showing disease risk reduction in response to ingestion of vitamin K1.86-90
Vitamin K2 (MK-4) . MK-4 is found in meat, eggs, and dairy products.91 It is the most studied form of vitamin K to preserve bone health. It is rapidly absorbed and rapidly metabolized by the body.92-96
Vitamin K2 (MK-7) . MK-7 is found in fermented soybeans and fermented cheeses.97,98 What makes this form so special is that it remains active in the body for more than 24 hours.84 This is critical when protecting against calcification since matrix Gla-proteins quickly inactivate in the absence of vitamin K2.99
The federal government says that adults only need 90 to 120 mcg per day of vitamin K.100-102 While this is enough to enable proper blood clotting, current research suggests it falls below levels needed to protect against vascular calcification.99,103-106
Results were measured by the reduction of uncarboxylated matrix Gla and other measures of systemiccalcification. Recall that when matrix Gla is under-carboxylated, it enables calcification of its surrounding tissue.
Supplementation with the MK-7 form of vitamin K2 reduced uncarboxylated matrix Gla by 36.7% in the 135 mcg dose group and 61.1% in the 360 mcg dose group. In the group given 360 mcg per day of MK-7, the favorable response rate was a remarkable 93%.83
When vitamin K2 supplementation was ceased in these dialysis patients, plasma levels of uncarboxylatedmatrix Gla-protein increased significantly, which indicated these high-risk individuals were once again vulnerable to severe vascular calcification.
Can Calcification Be Reversed?
Most adults probably suffer some degree of calcification, as intake of vitamin K in Western societies remains at epidemic low levels.
Some of us are severely calcified because of medical disorders requiring dialysis or the drug warfarin, or we allowed blood levels of homocysteine, LDL, or glucose to remain too high for too long.
So the question begs is there anything we can do now to reverse the accumulation of calcium in our arteries, heart valves, glands, and other soft tissues? We found one animal study published in 2007 suggesting that high-dose vitamin K might work. The authors of the study wrote: 99
"Given that arterial calcifications are predictive of cardiovascular events, regression of arterial calcification may help to reduce the risk of death in people with chronic kidney disease and coronary artery disease."
The study involved four groups of rats who were all initially fed a six-week diet that contained warfarin to induce calcium buildup in the blood vessels. This diet also included a low-dose (normal) vitamin K1 to ensure the animals were not vitamin K deficient. The rats were divided into several groups, of which the following four groups comprised the main part of the experiment:
Group 1: Continue thewarfarin plus normal K1 diet;
Group 2: Stop warfarin, but continue with normal dose of vitamin K1;
Group 3: Stop warfarin, but use a high-dose of vitamin K1;
Group 4: Stop warfarin, but add high-dose of MK-4 formof vitamin K2.
During the initial six weeks of warfarin plus normal K1, all animals showed a significant increase in arterial calcification.
In the groups receiving high-dose vitamin K1 or K2 (MK-4), not only was there no further arterial calcium accumulation, but there was a greater than 37% reduction of previously accumulated arterial calcification after six weeks. After 12 weeks, there was a 53% reduction in accumulated arterial calcium deposits.
The groups receiving the high-dose vitamin K1 and K2 also showed a reversal in carotid artery stiffness.99
This study provides intriguing evidence that warfarin-induced calcification may be reversible by high vitamin K intake.
An estimate of the human equivalent dose given to the rats whose arterial calcification was reversed is difficult to precisely calculate because of many variables involved. Our calculations based on estimates of food consumption and animal body weight suggest that the human equivalent dose of the vitamin K2 (MK-4)used in this study is in the range of approximately 52,000 mcg to 97,000 mcg per day (i.e. 52 mg to 97 mgper day).
Since the RDA for vitamin K is only 90 to 120 mcg, the dose of vitamin K used in this rat study may seem extremely high. Yet in Japan, the MK-4 form of vitamin K2 is approved as a drug to treat osteoporosis in humans, and the daily dose is 45,000 mcg (45 mg), which has not been reported to have any toxic effects.120-123
Most Life Extension® members take a combination supplement that provides 1,000 mcg of vitamin K1, 1,000mcg of vitamin K2 (MK-4), and 200 mcg of vitamin K2 (MK-7).
These are high doses compared to dietary supplement industry standards, and one could postulate that taking these daily doses over an extended time period might induce a regression of arterial calcification, but more human research is needed to establish this. Some members are taking higher doses of vitamin K now with the objective of reversing accumulated soft tissue calcification.
Systemic Calcification Cardiovascular tissues are particularly prone to calcium infiltration.
The calcification process, however, is also commonly observed in the skin, kidney, tendons, glands, and other soft tissues as a result of disease, and/or aging.124-132
How To Properly Supplement With Vitamin KA review of the published scientific literature provides a rationale for aging people to supplement with all three vitamin K forms, i.e. vitamin K1, vitamin K2 (MK-4), and vitamin K2 (MK-7).
Since vitamin K is fat-soluble, taking it with the fattiest meal of the day will greatly augment absorption into one's bloodstream.
A lot of members ask why they cannot take just the MK-7 form of vitamin K2 since this has long-acting effects in the body and has demonstrated powerful calcium blocking properties. Our response is that vitamin K1 and MK-4 have demonstrated impressive results in other studies, so it is best to take a formula that contains all three forms of vitamin K. As mentioned already, the MK-4 form of vitamin K2 has been used in high doses as a prescription drug in Japan to treat osteoporosis.
Since vitamin K1 and MK-4 are inexpensive, it makes sense to include them with the long-acting MK-7 form of vitamin K2 to inhibit and possibly reverse as much vascular calcification as possible, while providing support for strong bones.
Why Doctors Are Apprehensive About Vitamin KIn 1999, one of our scientific advisors recommended to me that aging people supplement with vitamin K.
Vitamin K is known as the "coagulation vitamin" because of the critical role in plays in essential blood clotting.
I was initially apprehensive because abnormal clotting inside blood vessels (thrombosis) is a leading cause of death in the elderly. 133,134 Thrombosis is a frequent underlying cause of coronary occlusion heart attacks and ischemic strokes.135,136
One might think that taking higher amounts of vitamin K would increase thrombotic risk. This concern, however, has no basis in reality. The reason is that only small amounts of vitamin K are required to fully saturate coagulation
proteins .137
Once coagulation proteins are fully saturated by vitamin K, then there is no increased thrombotic risk in response to additional vitamin K intake.
The misconception about the role vitamin K plays in coagulation is contributing to the epidemic of diseases caused by vascular calcification. A plethora of published studies indicate that the most common degenerative diseases afflicting aging humans could be prevented by taking the proper doses of vitamin K.
What mainstream doctors still don't understand is vitamin K's critical role of blocking the calcification of heart valves, arterial linings, and other soft tissues, while helping to keep calcium in bone where it is needed.
Eye-opening recent studies shed light on the importance for people to optimize their intake of vitamin K to protect against soft tissue calcification.
An urgent need exists to convey this information to the medical community. This may not happen any time soon because vitamin K is sold as a low-cost dietary supplement and not an expensive prescription drug.
For longer life,
William Faloon


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Everything San Miguel Corp. and Ramon Ang Have Donated for the Fight Against COVID-19
Including a lump of the tycoon's personal wealth.
By Anri Ichimura | Apr 7, 2020
IMAGE RAENA ABELLA
"What is more important are lives, not money," said San Miguel Corp. (SMC) president and COO Ramon Ang last week to CNN Philippines. "We can make money again, but life, once you lose it, it's gone forever. So between life and money, I'd choose life."
And now Ang is living up to his words after his conglomerate reported that its contributions to the fight against COVID-19 have reached P877.8 million as of April 4, 2020.
The corporation disclosed that its total donations currently include:
P500 million worth of personal protective equipment
P199.4 million worth of canned goods, meat products, biscuits, bread, coffee, and milk
P38.9 million worth of 70-percent ethyl alcohol (approximately 518,340 liters)
P38.4 million worth of rice (approximately 1.1 million kilos)
P1.1 million worth of free toll for over 2,000 medical frontliners, as well as donations to PNP and AFP stationed at SLEX, Skyway, and Star Tollway checkpoints
And there's no doubt that these numbers will grow as quarantine extends to April 30.
According to SMC, these donations have been given to affected and vulnerable communities, particularly the urban poor of Luzon who are now struggling to put food on the table.
If that wasn't enough, Ang and his family personally donated P100 million of their personal wealth to Project Ugnayan, a collaboration of the country's biggest businesses committed to feeding the urban poor in and around Metro Manila.
According to Forbes, Ramon Ang's net worth is currently estimated to be around $1.5 billion, and the tycoon has reportedly lost 46 percent of his wealth due to the economic impact of COVID-19. But as Ang has stated before, if given the ultimatum between life and money, this businessman will choose life every single time.
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Anri Ichimura
Section Editor, Esquire Philippines
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Do Supplements Help, or Harm?
Some studies of supplements actually found they increase the risk of death. But it may depend on how you crunch the numbers.
In recent times, supplementing the diet with vitamins and minerals has shifted from trying to prevent deficiencies to taking higher amounts of them in an effort to enhance health.
Vitamins, minerals and other micronutrients are needed in small amounts for good health. Without them, diseases such as scurvy will develop (Vitamin C). Some of the effects of vitamin and mineral deficiency have been known for hundreds of years and the amounts needed to prevent deficiency are given as the recommended daily allowance (RDA), formerly the minimum daily requirement.
as with everything else, it's almost certain that the effects of vitamins and minerals on health follow an upside down U curve: too little is bad for health and so is too much.
The SELECT trial (the Selenium and Vitamin E Cancer Prevention Trial) was designed to determine the long range effect of selenium and vitamin E supplements on prostate cancer. Previous studies had hinted that both of these substances might offer protection against prostate cancer. But the trial found a 17% increase in the risk of developing prostate cancer in men who took 400 units of vitamin E daily, and no protection against developing prostate cancer from selenium.
Over 35,000 men from the U.S., Canada and Puerto Rico were split into four groups in a randomized controlled trials. One group took 400 International Units of Vitamin E per day, the second took 200 micrograms of selenium a day, the third took both vitamin E and selenium and the fourth took only inactive placebo.
The results as of July 2011 found an increase in new prostate cancers among all three groups taking supplements, with the increase only significant in the vitamin E group. That group showed a 17% increase in the rate of prostate cancer compared to the placebo group.
The recently published article included results as of July 2011. It found an increase in new prostate cancers among all three groups taking supplements, with the increase only significant in the vitamin E group. That group showed a 17% increase in the rate of prostate cancer compared to the placebo group.
The selenium group showed a 9% increase and the group taking both selenium and vitamin E showed a 5% increase, increases that were not statistically significant and could have been caused by chance alone. The results of the group taking both vitamin E and selenium suggest that selenium somehow blunts the ability of vitamin E to increase prostate cancers.
The researchers don't offer a biological explanation for why vitamin E appears to increase the risk of prostate cancer. They do express concern that the rate of prostate cancer continued to rise even after subjects stopped taking vitamin E supplements, suggesting that harm continues for years afterwards. They also note a 2005 study that found that 50% of U.S. individuals over the age of 60 take vitamin E containing supplements and 23% of them are taking at least 400 IU of vitamin E per day. The SELECT study may give them a reason to reconsider this. The adult RDA for vitamin E is 22.5 IU a day.
At the start of the study, 66% of the study subjects reported using at least one supplement. This increased to 85% in 2004, with 27% reporting use of four or more supplements.
One possible scenario is that women were taking supplements in response to illness, which may have been the reason for their earlier deaths. But since most people can get all the nutrients they require from eating a balanced diet, the study does raise the question of whether routinely taking a vitamin or mineral supplement is a good idea.
The women in the study completed a 16-page questionnaire on their dietary and lifestyle habits in 1986, including supplement use. They were also asked about other factors such as their age, height, education, physical activity, diet and certain medical conditions, such as high blood pressure. Follow-up questionnaires were completed in 1997 and 2004.
Different types of statistical analyses markedly changed these results.
During the course of the study, 15,994 of the women died. Those who died from injury, accident or suicide were not included in the study results, since it's unlikely that supplement use could have played a part in those deaths.
The researchers analyzed the data for any association between supplement use and mortality, using validated statistical methods and adjusting the results for other possible factors known to affect mortality including age, lifestyle, smoking, alcohol and certain medical factors. And different statistical treatments gave different results.
Adding in adjustments for the non-nutritional factors listed above, only calcium gave a significantly lower risk of death. Copper, multivitamins, vitamin B6 and iron gave a significantly higher risk.
Robert M. Russell, M.D., Special Expert to the Office of Dietary Supplements (ODS) at NIH and former Senior Scientist and Director of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University told TheDoctor that, "Trying to make sense of observational epidemiology study results can at times be difficult. Different populations, study designs, lengths of follow up often can account for confusing and seemingly contradictory results.
"In general, what we have learned from an accumulating database from both observational epidemiology and interventional studies is that the vitamin and minerals are safe to take in RDA amounts (as are contained in most over the counter multi vitamin-multi mineral preparations). Further, we have learned that taking large amounts of single nutrients or nutrient combinations often lead to chronic undesirable toxic effects with implications for chronic disease such as cancer. We have seen this with beta-carotene with a stimulation of lung cancer at high doses, and now we are seeing a similar picture with high dose vitamin E vis-a-vis prostate cancer.


While increased security on the Mexican border has reduced the number of illegal crossers, it has also magnified violence among professional smugglers connected to drug cartels that often outgun U.S. Border Patrol agents.
Soon-to-be-released Homeland Security statistics reveal that the U.S. crackdown has indeed deterred Individuals from attempting to enter the country illegally, but it has also created a lucrative human smuggling enterprise operated by heavily armed drug cartels that charge up to $6,000 a person.
Essentially, smalltime smuggling operations have been replaced with sophisticated ones run by Mexico's notorious cocaine cartels. Smugglers now carry high-caliber weapons, use military tactics to evade capture and dress in camouflage uniforms. Often gunfights occur between rival smuggling gangs or gangs that hijack each other's human cargo as they make their way north.
Keep hiding your head in the sand. Ostrich is a good look for you. After all, it works for our government doesn't it?
The difference is that the US federal government has no Constitutional authority to waste taxpayer money Prohibiting forms of commerce.
Prohibition has never worked in the history of the US.
Isn't one definition of insanity, repeating the same mistakes of the past and expecting different results?
How did you come to this conclusion?.
See...at 17 you think you know it all, but you can't even recognize sarcasm when it walks up and kisses you on the mouth.
I have a few of those 17 YO's in my family. Oh yes they have opinions, so did I when I was 17, my gosh did I ever learn how little I really knew when I started raising a family of my own.
Circular reasoning doesn't do much for your argument. Why are the Minutemen on the border if the towers were not on the border?
Do you also suggest the Minutemen muster for the "driving militia" to prevent those deaths from, mostly, legal residents in the US for national security reasons?
Oh no of course not, they're doin a great job where they intended to, helping secure the border to keep foreign intruders out!!
The news reported that the towers, which are not on the border, are the ones that got attacked. I have never heard of any news reports of our borders being attacked by terrorists.
Wouldn't it be more cost effective, if we used better and more market friendly public policy that actually reduces public and private sector costs?
What are you talking about,,,cost effective??? the minutemen don't cost us $$ Sounds like a cheesy political quote gone astray!
Well, ya know--if you feel that strongly about it, work to change the law. But for now, our federal laws prohibit the sale and importation of narcotics such as heroin and cocaine.
I guess you have no problem with some drug dealer offering your kids crack--you have no problem with some sleazeball selling or giving a drug to your daughter that is so highly addictive it could likely bring her to a point in her life where she would lie, cheat, steal, and prostitute her body to get it.
I suppose you're one of those cool parents who gives drugs and alcohol to your kids because hey, if you tell them they can't have it, they'll just do it behind your back.
All the more power to you then Mr. Federalist.
I'm not a member but know some that are.
How do those minutemen support their families?
You may be right about the Minutemen, but then again, what are they doing on the border, when the terrorists used airplanes? Are they going to simply watch, potential, terrorists fly overhead?
Which laws are you suggesting I change? The federal government has no constitutional authority to Prohibit commerce. How do you change laws that have no basis in our Constitution to begin with? If being unconstitutional were as illegal as the misdemeanor of jaywalking across a state line, the Minutemen would be patrolling Washington DC, instead of the border.
Legal drugs are just as bad. Ask Rush Limbaugh. I don't think we would have as much of a problem if all drugs were merely Regulated, as enumerated in the Constitution, instead of non-constitutionally Prohibited. The pharmaceuticals could make designer recreational drugs that are much less harmful than anything an amateur could manufacture in a bathroom lab.
No. I am one of those parents who believes in the Ninth Amendment to our glorious Constitution. Unfortunately, many people who profess it but don't act upon it, would actually prefer an all-powerful "communist" style government that can tell people who they can or can't hire, to our current form of federalism that has a built-in separation of powers.
Doesn't the Pledge mean anything to anyone? Why do we still have "under God" in the pledge, if so many people feel it is ok to be hypocrites?


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Genesis Compound Bow Left Hand Green. Single cam bow designed to be easy to shoot for any archer. Zero let-off single cam technology allows the bow to be shot at any draw length without making adjustments. Built to withstand the punishment of multiple shooters in youth programs, range use, or video target systems.
The only bow allowed in the NASP program. Draw Weight: 10-20 lbs, Draw Length: 15-30", Axle to Axle: 35.5". Includes flipper style arrow rest and nock point.
The item "Genesis Compound Bow Left Hand Green" is in sale since Wednesday, June 27, 2018. This item is in the category "Sporting Goods\Outdoor Sports\Archery\Bows\Compound". The seller is "bowhunterssuperstore" and is located in Wellsville, Pennsylvania. This item can be shipped worldwide.


For http://visual6502.org/sim/varm/armgl.html, would be much nicer that dragging would pan rather than "3D rotate" the view. The panning with wasd is too slow and not compatible with some keyboard layouts.
And of course zooming around mouse cursor rather than around center of screen would also help to zoom towards the part you want.
The 3D rotation is gimmicky but not actually useful to see the gates, and the current UI just doesn't let me zoom to gates I want without spending too much effort fighting the slow panning and the zooming target.
Without the conditional moves (MOVLE and MOVGT) after the compare (CMP), you'd have to branch after the compare, which is wasteful."
How are those those two conditional moves after the CMP operation more efficient than branching? Aren't they kind of branches themselves? What would the alternative "branching" sequence look like then?
The big deal is the conditional branch (the bgt). If the processor gets it wrong it's a pipeline flush. And best case you still have extra instructions for the branches. The conditional mov example is a fixed cost of a single "wasted" cycle, which matches the best case of the branching example (branch correctly predicted to mov r0,#1 and fall through). The worst case for the branching version is probably somewhere ~15 cycles depending on the uArch, but is still 1 cycle for the conditional move.
All of that being said, the branching version tends to be nicer for OoO cores since there aren't data dependencies on the flag registers any more, hence why you see RISC ISAs designed for OoO cores removing conditional execution for most instructions (AArch64 and RISC-V standout here).
So for a simple if/else, it was usually both less code and faster to use a straight line of conditional instructions. In more complicated cases, if the programmer was feeling clever, it was possible to update the status flags to get three-way (or more!) conditionals in straight-line branchless code. Fun!
The conditional moves convert into a NOP when the condition is false.
The idea here is that a branch results in a pipeline flush which takes a couple of cycles to refill.
In practice, most CPUs have very good branch predictors these days and conditional moves aren't all that useful anymore.
That's probably the reason why they don't exist for later ISAs such as RISC-V.
A real branch would involve a jump instruction somewhere. With a branch, different code executes depending on the condition. With the code above, you get different data depending on the condition.
Thanks for all the great explanations and insights. I really appreciate it. Cheers.
>"The ARM2 had pretty much the same instruction set as the ARM1, although featured new multiplication and (later) atomic swap instructions."
Does this mean that the ARM1 didn't support any atomic operations or were they using something else besides "compare and swap"?
The ARM1 did not have any atomic operation. You only need those if you have more than one processor. It also lacked the multiply and multiply-accumulate instructions, as stated above. These took multiple cycles, which is not very RISC-like. That is also true of the load multiple and store multiple instructions of the ARM2 (I don't remember if the ARM1 had them). The ARM2 also added the coprocessor interface.
Ah of course there were no mutli-cores back then. That makes total sense. Thanks.
Does anyone else find it slightly entertaining that this is an article from a news outlet titled "The Register"?


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Ravens-Browns Preview: Lamar Jackson, Baltimore Look To Clinch Home Field
Filed Under:Baltimore Ravens, Cleveland Browns, Lamar Jackson, NFL On CBS, Norm Elrod
(CBS Baltimore) — The Baltimore Ravens (12-2) have the inside track on home-field advantage throughout the playoffs. Led by MVP candidate and breakout star Lamar Jackson, the Ravens have become the team to beat down the homestretch. The Cleveland Browns (6-8) are barely holding on to their last shred of playoff hope. The Browns haven't really improved on their almost-.500 2018, and Baker Mayfield hasn't emerged as the high-end starter last season portended. But the team and Mayfield have shown flashes.
Both of these AFC North rivals have something to play for in their Week 16 matchup. The Ravens need to keep their foot on the gas to maintain home-field advantage. The Browns will need to string together a more complete game to have any shot at playing in January. As an added bonus, each team would certainly enjoy spoiling the other's holiday season with a late December loss.
Everyone suspected the Ravens could improve on last season's 10-6 record and first-round playoff exit. Their 12 wins so far this season ensure the first, and a likely first-round bye would accomplish the second. But that's just part of the story and doesn't explain how they got here, riding a 10-game win streak and on the cusp of the franchise's first-ever top seed in the playoffs.
Stream your local NFL on CBS game live with CBS All Access.
Jackson ended last season as an electrifying athlete who needed to develop into a legitimate NFL quarterback. The Ravens ran a stripped-down passing attack that limited his exposure to mistakes but also limited his chances for success. The Ravens's success going into the 2019 season depended on his development as a passer.
Clearly Jackson, an NFL offensive MVP candidate, has made great strides. He's coming off an absurd five-touchdown performance against the New York Jets. Scarier still, it was Jackson's third five-touchdown game of the season. The first came against the Miami Dolphins in Week 1; the second happened against the Los Angeles Rams in Week 12. He has 33 TD passes total so far.
Jackson isn't the league's most prolific passer in terms of yardage. The Ravens average only 207.6 yards passing per game, which puts them in the bottom half of teams by that measure. But their running game is by far the best in the NFL, with an average of 202.1 yards per game, more than 50 yards better than the next highest team. And Jackson has flourished in a system that allows him to read defenses and react.
For all the talk about the Ravens offense, their defense has quietly become an asset rather than a liability. They allow 314.3 yards per game, sixth best in the league, and 18.4 points, fourth best on the season. But over the course of their 10-game win streak, the Ravens defense has been in the best in football. In that time, they've held the Seattle Seahawks, Houston Texans, Los Angeles Rams and San Francisco 49ers each to under 20 points.
The last team to beat the Ravens, of course, was the Browns. (And don't think both teams aren't using that game as motivation.) But since their last meeting, these teams' seasons have diverged. The then 2-2 Browns, have since won four games and lost six. The win over the team that would become the NFL's best, became a watershed moment, though not in the way any teams hopes. Cleveland dropped their next four games.
Losing to some of the league's best teams, including the San Francisco 49ers and Seattle Seahawks, showed that these Browns weren't really ready for prime-time. Baker Mayfield, Jackson's 2018 NFL Draft-mate, proved to be incapable of leading the Browns out of mediocrity. Any success the offense had this season seemed to be paired with failure. Look no further than Mayfield's 17 touchdown passes and 17 interceptions on the season.
Odell Beckham Jr. has let it be known that he is not pleased, though it seems like the prima donna wide receiver wants to stay in Cleveland. The Browns should not be pleased either, given that the elite receiver has posted less than elite numbers — 67 catches, 910 yards, two touchdowns.
Through it all, Nick Chubb has been a nice surprise though. The Browns running back leads the league in yards per game (100.6), and is the only back in the league averaging 100-plus yards. Whether that will be enough in a one-dimensional offense facing one of the league's best defenses is another story.
As NFL On CBS sideline reporter Evan Washburn recently noted about Cleveland, "as dysfunctional as it appears right now, you never know at any moment if all those pieces could decide to come together and have a day. Maybe it's a quarter. Maybe it's just half a quarter, and that is all they will need to keep it close or steal a win from Baltimore," said Washburn. "I think that is at the forefront of the Ravens mind. I know for a fact that the way they felt after that Week 4 loss was embarrassed. And that's in the front of how they are approaching this rematch."
Browns coach Freddy Kichens could be playing for his job. Mayfield may be as well. But don't expect any sympathy from a Ravens team looking to clinch home-field advantage throughout the playoffs.
The Ravens play the Browns Sunday @ 1 p.m. ET on CBS.


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rainangel
Decapitated head of 2,000-year-old Egyptian mummy found in UK doctor's attic
August 8, 2022 August 5, 2022 - by rainangelorg
The mystery behind a decapitated mummy head that was discovered in the attic of a British doctor 's home has been solved.
The ancient Egyptian mummy was put under a CT scanner, revealing it once belonged to a woman who lived 2,000 years ago.
Her tongue was remarkably reserved while her teeth were well worn due to a rough diet, and her brain was removed, scans showed.
But, the exact origins of the mummified head remains unsolved, according to researchers at Canterbury Christ Church University.
One theory is that it was brought back from Egypt as a souvenir in the 19th century and passed down as an heirloom.
Mummies were popular during the Victoria era when people hosted unwrapping parties and enjoyed the process of pulling away the wrappings of a mummified body.
Lecturer James Elliot, an expert in forensic radiography, said: "The head was found in the attic of a house in Kent which was being cleared out following the death of the owner.
"During the Victorian times, items like this used to be brought back from Egypt as souvenirs and may well have been passed down through generations to the person who owned it."
Researchers have been examining the mummy head since it was donated to the team in November 2020.
An initial CT scan was carried out the following year followed by further scans that uncovered details of the person's gender and diet.
The woman's worn teeth suggested she ate grains which were a staple food among the ancient Egyptians.
It also showed a type of tube within her left nostril.
Mr Elliott, who has a background in archeology, said: "The scan provides a huge amount of information.
"Everything from dental status, pathologies, method of preservation as well as assisting estimations of age and sex.
'Whether the tubing is historic [Victorian] or ancient [Egyptian] is unknown."
Researchers will analyse all of the scans again in the next stage of the project, hoping to find out more about dental status and any possible disease, injury or trauma.
They will also try to determine how the woman's brain was removed.
"Ironically, the ancient Egyptians believed that a person's mind was held in their heart and had little regard for the brain," Mr Elliott added.
"Regardless of this, the brain was removed to help preservation of the individual."
The team will also run ancient DNA tests and carbon dating as part of their scientific investigation before moving on to create a facial reconstruction of the woman.
It's hoped the findings will help to understand the wider picture of mummification and will be published in a scientific journal.
Mr Elliott said: "We plan on using the scanning data to create a three-dimensional replica of the head and possible facial reconstruction to allow a more intensive study of it without exposing the actual artifact.
"Similar reconstructions were made with Ta Kush, the mummy at Maidstone Museum."
Mr Elliott explained how mummification was common practice within ancient Egypt but with the advancement of CT technology, more detail can be researched on ancient traditions.
"Beginning in 3500 BC, mummification was a way to safeguard the spirit in its journey to the afterlife," he said.
"Mummification was common practice within ancient Egypt for both commoners and royalty, although with different levels of complexity and accompanying wealth."
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Farr Residence is a mountain contemporary home designed by Studio 80 Interior Design with a warm, inviting and elegant appeal in Colorado.
This double volume foyer has been transformed into a cylinder of rustic contemporary appeal that boasts a textural story of mountain life complete with random flagstone flooring that suggests the natural stone of the mountain side itself; walls clad in rough wood boards held together with metal strapping as though the room was the inside of a wine barrel; exposed ceiling beams that wrap the round room and come together in the center to form a turret with square clerestory windows repeated around the walls above the strapping. A stunning light fixture that is suspended at the same level as the metal strapping and tells the tale of a wagon wheel referencing the strapping as the wheel itself; and finally a round faux pony skin covered bench with shoe shelving that is reminiscent of a coin operated bull ride. This foyer is a fantasy come true for anyone with an imagination and a taste for whimsy.
The kitchen boasts all the modern essentials, complete with a commercial grade stove and center island. The island picks up on the dining room angles by being narrower at its base then the counter and this is further emphasized by the bar over hang. The bar stools bring in a vintage flare while the faux skin rug on the floor has a country appeal.
Much like the living room, the dining room features exposed posts, beams and window surrounds, but here they are featured in a room of angular dimensions. Narrower at the floor line then the ceiling, it is as though the pitched ceiling is pushing the walls outward with the only thing holding it together being a metal rod crossing the center section of the room. This metal rod is part of another wheel reference; only this time the visual is within the support detail rather then in the two simple pendants that are suspended from it. Creating additional flare within the room is a vintage china bureau and a contemporary table that is paired with modern chairs, all three creating a purposely-neutral color story that allows the fuchsia area rug to be the soprano within the room.
The kids bedroom continues the country rustic decor via the patchwork quilt and found board bed frame. The small desk, floor lamp and safety rail on the suspended bed bring in an industrial flavor while the Lucite chair reminds us that this is a contemporary home.
The counter on the vanity continues the color story of the tub and the contemporary faucet and mirror supports reinforce the industrial aesthetic.
In the bathroom, each coin nickle has been glued individually, then grouted and sealed. It's a lot of work but well worth the effort!


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Tommaso Pardi
Mr Tommaso Pardi MSc
School of Metallurgy and Materials
txp754@student.bham.ac.uk
Elms Road
B15 2SE
Tommaso Pardi is a PhD student in the School of Metallurgy and Materials at the University of Birmingham.
He is a member of the Extreme Robotics Lab, where he is working on grasping, manipulation and cutting for robotics applications in hazardous environments. Also, he is interested in Deep Learning and Deep Reinforcement Learning techniques. Previous areas he has worked on include soft-grasping and soft-robotics; teleoperation; and multi-UAVs coordination and control. He has competed in different International Robotic challenges.
MSc in Robotic and Automation Engineering, 2015
Bsc in Computer engineering, 2012
He qualified with BSc in Computer engineering (2012) and a MSc in Autonomous and Control engineering (2015) from University of Pisa.
After his graduation, he worked for 9 months in a spin-off company of the University of Pisa as Analyst Programmer, and then, as a research fellow for 1 year and a half at the BioRobotic Institute of the School of Advanced Studies Sant'Anna in Pisa.
In his previous experiences, he worked on soft-robotics, grasping manipulation, robotic teleoperation, and UAV controls.
He competed in two important International Robotic Challenges: the first edition of the Amazon Picking Challenge in Seattle (2015) and the Mohamed Bin Zayed International Robotic Challenge (MBZIRC) in Abu Dhabi (2017).
Postgraduate supervision
Rustam Stolkin
Amir Ghalamzan
Robotics in extreme environments


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In response to criticism by protesters, aimed at the neoliberalization of universities, governments often reply that "they are investing more" in universities than ever before. This argument often has a silencing effect, it is often seen and experienced as an effective rebuttal of the protesters' claims.
It also fits nicely with the general call, repeated endlessly, that "the best possible investment is investment in education". From Warren Buffett and the World Economic Forum down to local city councils and poverty-combating NGO's: the same message is broadcast over and over again. Invest in education, and you will increase employment rate, build superior skills for the workforce of the future, produce surplus value and become innovative that way, and fight poverty most effectively. "Investing in education" is generally perceived as uniformly and unambiguously good, something we all want and something of which all of us would massively benefit. Governments pulling that rabbit out of their hats, therefore, can align their discourses with massively consensual ones at societal level. Which increases the silencing effect of the argument on protesters claiming a more democratic and low-threshold university.
The argument is very easy to answer though. The issue is what EXACTLY governments are investing in? The fact of investment itself is entirely conditioned, as to usefulness and impact, by the actual aspects of university life that receive the investments. And looking at these, we see that such investments usually go to constructing or strengthening a high-end elite environment of competitive science: new state-of-the-art labs specialized in research that can be immediately converted into market value. Or some "top" recruitment of celebrity professors capable of attracting loads of new students. "Low end" activities, on the contrary, are usually the object of disinvestment (think of student facilities, adjunct academics, basic infrastructure).
So the issue is: where do the investments actually go to? After all, a company can say that it "invests" in its factories by repainting their façades.
Public lecture, Athens 27 February 2015.


The Independent Living Centre is a charity based in Semington, near Trowbridge, offering free and impartial advice to older and disabled people living in Wiltshire and BaNES.
We have the entire ground floor of an old hospital building, (click here to see the history of the centre) with a vast range of different mobility equipment available for assessment with our Occupational Therapist. No referral is necessary to book an appointment, and all assessments are tailored to your own specific requirements. We do not sell or provide the equipment demonstrated, so there is never any worry about feeling pressured to buy. We do have a limited Medequip retail shop on site where you can purchase smaller items such as grab rails and cutlery if required.
Unfortunately we are unable to offer home visits, but we can give advice over the phone, email, or post information packs out. We are also happy to give information to carers, family, friends and professional staff.
Our Benefits Adviser works two days a week and can advise on disability benefits, help complete forms, and aid with appeals. We also offer wheelchair hire, and have a library of information on things such as accessible holidays and days out. Click here or follow the navigation bar above to find out more about the ways we can help.


More online debate about teaching handwriting.
I am ALSO in support of teaching 'touch-typing' for competent keyboard skills - but not at the expense of teaching print and joined handwriting. I don't view this as an either/or scenario.
I suggest that if teachers were better at teaching print and joined handwriting, then this wouldn't be such an issue in the first place.
In other words, should people be debating whether or not we should teach handwriting - and whether we should teach joined (fully cursive) handwriting - or should the discussions be around how well teachers teach handwriting - and whether teacher-training addressed this skill in the first place?


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WItherfall to tour as Support for Moonspell and Swallow The Sun!
WItherfall will be hitting the road this fall with fellow Dark Melodic Metal legends Moonspell and Swallow the Sun! Due to the pandemic and other related issues this will be the first Witherfall tour around last years highly acclaimed "Curse…
Vocal Isolation Video for As I Lie Awake Released
We have had quite a few request for this so here it is the first installment of the isolated vocal tracks from "Curse Of Autumn" As I Lie Awake!
Watch, Enjoy, Comment and share
https://www.youtube.com/watch?v=HNh2cHrHou8&lc=UgzYIkagjTacbGls3J54AaABAg
Witherfall announce new Drummer Chris Tsaganeas
ATTENTION WITHERFALL LEGION: we would like you all to extend a warm welcome to our new drummer Chris Tsaganeas! Chris is a dynamic and versatile percussionist that has a feel for multiple genres. We were blown away with Chris' precision…
Witherfall - Nocturnes and Requiems turns 5 years old today!
Today marks the Five Year Anniversary of the release of WITHERFALL's debut album NOCTURNES AND REQUIEMS. Mixed and Mastered by Zeuss, Produced by Joseph Michael and Jake Dreyer. The only Witherfall album to feature original drummer Adam Sagan who died…
Marco Minnemann The Other Side of Fear Drum Playthrough
Marco Minnemann - Witherfall - The Other Side Of Fear Drum Playthrough
https://www.youtube.com/watch?v=y5uTbs5ZDxY
Check out this ridiculous display of technique and power from Witherfall "Curse Of Autumn" Drummer Marco Minnemann. (The Aristocrats, Joe Satriani, Jorden Ruddess, Necrophagist…
Century Media/Sony Recording Artists WITHERFALL ANNOUNCE FULL-TIME DRUMMER AUDITIONS
los angeles, CA, December 21, 2021 For Immediate Release: December 20, 2021
Los Angeles-based dark melodic metal outfit Witherfall are hosting…
Tshirt and Signed Wine Bottle Giveaway
GIVEAWAY TIME! Enter for your chance to win 1 of 24 bundles! Each bundle includes 1 Witherfall T-shirt, as well as an empty bottle of our TEMPEST red blend wine which we consumed during the recording of our album CURSE…
Witherfall Christmas and Black Friday Sale
Hello everyone! We hope your thanksgiving was free of political arguments and strife. It's been a rough couple of years for us and the entire Music industry but we are coming back strong. We will have some great news regarding…
New Witherfall Tab Books with Guitar Pro Download files!
We are very pleased to announce the newest addition to the Witherfall merch store. The Curse of Autumn complete guitar tablature book. We teamed up with transcriber Evan Bradley to painstakingly transcribe all of the individual guitar tracks from Curse…
Witherfall Wine Presale Discount ends soon
Pre-sale price goes away on Monday, get yours now before they are gone!
https://charlieandecho.com/product/2020-witherfall-tempest/
Rated 91 by WineEnthusiast
https://www.winemag.com/.../charlie-echo-2019-witherfall.../
What happens when a Los Angeles metal band teams up with a natural winemaker in San Diego…
Witherfall covers Boston - Foreplay/Long Time our version Out Now!
After entering several international charts with their latest album, "Curse Of Autumn", WITHERFALL are releasing a special cover of Boston's illustrious "Foreplay/Long Time", entitled "Long Time (Long Version)". The song has been available as Acoustic Version on "Curse Of…
Witherfall - Boston Cover Clip
This song is our Tribute to one of the greatest voices in rock and roll history Boston Vocalist Brad Delp who in 2007 tragically took his own life... The re-working of this song reflects the true emotions behind the lyrical…
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Despite weather advisories, icy roads and chilling temperatures, hundreds gathered at First Baptist Church, Trussville, to hear from six speakers at the State Evangelism Conference on Feb. 24.
Josh Lancaster, pastor of Underwood Baptist Church, Florence, opened the morning session with the message "Dealing with Disappointment" from 2 Samuel 7.
"You are an individual person and God deals with you individually. God is personal, He knows your wishes. He knows your ways. … God's 'No' today doesn't mean it will be forever," Lancaster said.
Dan Garland, LifeWay Christian Resources regional director, urged those in the congregation to focus on the hurting and "the 'one' instead of the masses" when sharing the gospel, referencing from Acts 3.
Herb Reavis Jr. shared from Acts 20 at the conference.
"If you're going to reach your community it's going to take a worship service that is alive," said Reavis, pastor of North Jacksonville Baptist Church, Jacksonville, Fla.
"Worship should be a time of celebration, adoration, proclamation, illumination and elevation. We are surrounded by a culture of darkness but we've got the Light and I believe that when people come to church they ought to get the gospel. The gospel gives people light.
Scott Dawson, of the Scott Dawson Evangelistic Association, shared during the afternoon session, relating ministry to running a marathon.
There's a start to the race, running the race itself and finishing the race, Dawson said.
He said there are three marks that should be on a believer's life in order to "finish the race" of ministry. 1) You will be spiritual. 2) You will be humble. 3) You will be persistent.
"If we're going to have a ministry that lasts, it's not about me. It's all about Jesus. Be passionate about Jesus," Dawson said.
"Faith demands action. … I believe we see churches falling apart because we haven't attempted to do anything bigger than us in a long time," Hammond said.
For the morning and afternoon sessions, participants heard several familiar and several new songs from Daniel Crews, resident artist at First Baptist Church, Jacksonville, Fla.
Kevin Hamm, pastor of Gardendale First Baptist Church, was the evening session speaker, with special music by the church's choir and praise team.
Hamm shared from Mark 2 and suggested four reasons why American doesn't see revivals anymore. 1) There is no real burden for the lost. 2) There is no real passion for Jesus. 3) There's no real openness to change. 4) There's no real celebration in the church.
Look for a full coverage of the conference in the March 5 issue of The Alabama Baptist.


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Mark Carney Defends The Bank of England: "We Are Not Robbing The Poor To Pay The Rich"
December 5, 2016 by Infinite
– Mark Carney Defends The Bank of England: "We Are Not Robbing The Poor To Pay The Rich":
In a speech delivered at the Liverpool John Moores University on Monday, Bank of England head, and former Goldman partner, Mark Carney defended his central bank's near-zero borrowing costs which have been increasingly criticized by local politicians ever since the Brexit vote, claiming that central bank monetary policies have not been the cause behind wealth transfer.
Carney said the BoE's actions had softened the hit to Britain's economy since the global financial crisis, easing the blow for poorer households who suffer most from recessions.
"Has monetary policy robbed savers to pay borrowers? Has the MPC been Robin Hood in reverse? In a word, no."
Which is surprising, because in many more words, some 20 pages worth, in March of this year, the BIS released a research report titled "Wealth inequality and monetary policy", in which it said that its "simulation suggests that wealth inequality has risen since the Great Financial Crisis. While low interest rates and rising bond prices have had a negligible impact on wealth inequality, rising equity prices have been a key driver of inequality" and conclude that "this suggests that monetary policy may have added to inequality to the extent that it has boosted equity prices."
So, in more than one word, yes.
That said, we can understand why Carney feels threatened: in October, Prime Minister Theresa May said the BoE's policy of cutting interest rates to just above zero and buying hundreds of billions of pounds worth of government bonds had "bad side effects" for savers.
Carney said most people whose savings income had been hit by low rates had gained from a rise in value of assets, paradoxically citing data which showed only 2% of households had savings of over 5,000 pounds, but few other assets and did not own a home. Meanwhile, what Carney ignored is that according to the annual high net worth report by Credit Suisse, the net worth of the pinnacle of the global weath pyramid, those 0.7% of global adults who are worth more than $1 million, has nearly doubled from $69.2 trillion in 2010…
… to over $116 trillion in 2016…
… even as those adults who were worth less than $10,000 in 2010 had a combined net worth of $8.2 trillion, a number which has since declined to $6.1 trillion in 2016 despite a half a billion increase in the sample size, while the combined net worth of the layer worth between $10K and $100K also declined from $32.1 trillion to $29.1 trillion, confirming the rich got richer, while the middle class (and poor) got even poorer.
So if not monetary policy, then what was the culprit according to Carney for record wealth inequality and such political shocks as Brexit, Trump and Renzexit? Here the central bank chief offered a familiar scapegoat, one first proposed by none other than the IMF itself: globalization, which in March the IMF accused of being the catalyst behind rising inequality and market crashes.
In his paper, Carney warned that "to address the deeper causes of weak growth, higher inequality and rising insecurity requires a globalisation that works for all." Oh, so now, 8 years later they decide that globalization was only working for "some."
Only Carney took it one step further, and he did not explicitly blame globalization, but rather the threat of doing away with it entirely, and warning about the risk of a return of protectionism in the global economy, a concern which has grown for investors since the election victory of U.S. President-elect Donald Trump. "Turning our backs on open markets would be a tragedy, but it is a possibility. It can only be averted by confronting the underlying reasons for this risk upfront," he said.
Because why not just blame Trump now: after all, in just a few years when global economies and stock markets are crashing, everyone will be doing it, may as well have a head start.
Finally, Carney reiterated his view that the BoE was prepared to further slam the poor and middle classes by letting British inflation run above its 2% target, in the process hurting those who Carney is suppoedly protecting, and not been a "Robin Hood in reverse to."
"The MPC is choosing a period of somewhat higher consumer price inflation in exchange for a more modest increase in unemployment," he said. "There are limits, however, to the extent to which above-target inflation can be tolerated."
Those limits will be tested when millions of poor people realize just what running "somewhat higher consumer prices" means to their bottom line, and their already soaring anger at a political establishment that continues to test the breaking limits of some 90% of the population just so it can, one day, inflate away the world's gargantuan debt load.
Categories Economy, Global News, Politics, Society Tags Bank of England, Economy, Global News, Government, Mark Carney, Politics, U.K. Post navigation
Rival gangs clash in mass brawl on Birmingham street (VIDEO)
The Recount …


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Did Olympians really crash Grindr in London?
By Cyd Zeigler@CydZeigler Jul 23, 2012, 11:43am PDT
Share All sharing options for: Did Olympians really crash Grindr in London?
Call me a little dubious, but I find the whole "Olympians crash Grindr" story to be unlikely at best. In case you missed it, gay hook-up application Grindr claims its servers were overloaded and crashed when Olympic athletes began arriving in London. The city of London has 8 million people. A whopping 11,000 athletes are competing in the Olympics. Even if 10 times that amount were coming, it would still only be an increase of 1% of the traffic.
Unless the Grindr folks are claiming that all of the Olympic athletes, gay and straight, suddenly started looking for guys to hook up with when they landed in London, it's impossible to believe there's any validity to the story. Still, if you see this profile show up on your phone, please please please let us know....
PHOTO: Ryan Lochte prior to competing in the mens 200m backstroke final in the 2012 U.S. Olympic swimming team trials at the CenturyLink Center. Mandatory Credit: Andrew Weber-US PRESSWIRE
Former pro Australian basketball player Trevor Torrance publicly comes out as gay Torrance, who played at the height of the AIDS epidemic, is finally free to tell his story.


These presentations are classified and categorized, so you will always find everything clearly laid out and in context. You are watching FREE PDF Download Readings for Diversity and Social Justice FULL VERSION presentation right now. We are staying up to date!


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ulfSCHNEIDER
Ulf Schneider
Imprint & Privacy
Ulf Schneider, born in 1968, studied in Hannover, New York and Berlin with Jens Ellermann, Felix Galimir, Masao Kawasaki and Thomas Zehetmair. His artistic development was strongly influenced through impulses from Hatto Beyerle, Eberhard Feltz, Nikolaus Harnoncourt and Sir Roger Norrington.
In 1991/92 he founded the Trio Jean Paul together with Martin Löhr (violoncello) and Eckart Heiligers (piano). As a member of the trio he was awarded first prizes and several special prizes at the international chamber music competitions in Melbourne and Osaka as well as at the German Music Competition in Bonn.
Extensive international concert activities with the Trio Jean Paul, with his duo partners Stephan Imorde and Jan Philip Schulze and with the Bartholdy Quintet regularly take him to the great centres of music such as the Philharmonies in Berlin and Cologne, Alte Oper Frankfurt, Wigmore Hall London, Tonhalle Zurich, Sydney Opera House, Konzerthaus Dortmund, Mozarteum Salzburg, Vienna Konzerthaus, Palais des Beaux Arts Bruxelles, Concertgebouw Amsterdam and Gulbenkian Foundation Lisbon.
He is a welcome guest at important festivals such as the Rheingau Musik Festival, Schleswig-Holstein Festival, Mecklenburg-Vorpommern Festival, Berlin Festwochen, Beethovenfest Bonn, Mozartfest Würzburg, Edinburgh Festival, Lucerne and Ludwigsburg Festivals, Heidelberger Frühling, Niedersächsische Musiktage, Kissinger Sommer, the Schubertiade Schwarzenberg, among others.
As soloist, Ulf Schneider has appeared with the Württemberg Chamber Orchestra Heilbronn, Beethoven Orchester Bonn, berliner Sinfoniker, Musikkollegium Winterthur, Orchestra I Pomeriggi Musicali Milano, Presidential Orchestra Ankara, Nordböhmische Philharmonie Teplice, Dallas Symphony,Tucson Symphony, WDR-Sinfonieorchester Cologne, Radiophilharmonie Hannover, Tonhalle-Orchester Zürich, Orchester des Prager Nationaltheaters with conductors such as Jörg Faerber, Antonello Manacorda, Charles Olivieri-Munroe, Eiji Oue, Petri Sakari, Marc Soustrot, Erich Bergel, Gerd Schaller, George Hanson, Jukka-Pekka Saraste, Jaap van Zweden and Sylvain Cambreling.
Since 2001, Ulf Schneider is Professor at the Hannover University of Music, Drama and Media. Many of his students are prize-winners of national and international competitions, members of leading European orchestras, teachers at German universities for music as well as chamber musicians in renowned ensembles. Ulf Schneider is regularly invited to teach master classes, as well as serve as member of the jury for national and international competitions.
He is dedicated to the project Rhapsody-in-School and the PE-Förderungen für Musik Mannheim, an association supporting outstanding young musicians.
Ulf Schneider plays a Joannes Florenus Guidantus violin from Bologna, 1725.
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Q: Actionscript 3: Sequence Diagrams for Event Handling i have to draw some sequence diagrams for a software i wrote. In my Software i have some Objects that dispatch custom Events and other Objects that listens for these events.
When it comes to illustrate Eventlisteners und dispatchEvent-function i'm a little bit confused how to do that. I googled a lot, but couldn't find the right hint :(
Or is a sequence diagram not a good choice for explaining event handling?
Thanks for your help!

A: There is no definitive answer to your question, because creating useful diagrams largely depends on what kind of information you want to convey to the reader.  My advice is: You will never be able to show all your program's functionality in just one diagram; event handling is often too complex and ugly - try to split it up into smaller parts and decide individually, which kind of diagram is useful for which aspects you want to show.
For each one, your focus should always be on the reader: What do you want him or her to understand?
To start with, it's usually best to write user stories and show use cases, if you don't have those already. They convey the functionality your program was made for, and help you to identify processes and organize the way in which you think about your program.
For each of those processes, a sequence diagram is probably most useful to show how things work.  For example, if one of your program features is uploading an image, you should draw a sequence diagram showing the main components, objects and sequences of events involved only in the upload procedure.
The next step is to categorize the remaining events and objects, which are more fine-grained or do not interact directly with the user: Which events are internal (i.e. dispatched and handled within the same object), which are external (between some objects), or even global (affecting the entire application).  This will help you to identify groups of objects interacting with one another.
Depending on how complex an object is, I often display internal event sequences within a state diagram or flow chart.
If you have some smaller object groups where the interactions are not too complex and more interesting in terms of who does what why instead of when, you can possibly use slightly altered class diagrams - these might not be very formal, but for some concepts, they are often more useful than flow charts, state or sequence diagrams.
It should also be mentioned, that in some cases, a diagram doesn't really help at all. Sometimes it is far more useful to write a short text providing an example, or collect information in tables.  Documentation is complete, when a reader understands the concepts of what your program does and how it does so.  For everything else, there is always the source code.

A: I don't know exactly what you are trying to do here but sequence diagrams are perfectly capable of representing the sort of system you have described. Here is an article on sequence diagrams. Look at the section on asynchronous messages and concurrency. Another article actually has an example of an event listener. It talks about both sequence and class diagrams. I guess the example of sequence diagrams will be of interest to you.

redpajama_set_name: RedPajamaStackExchange


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Home Actor Liev Schreiber Net Worth
Liev Schreiber Net Worth
What is Liev Schreiber's Net Worth?
Liev Schreiber Net Worth and Salary: Liev Schreiber is an American actor, screenwriter, and producer who has a net worth of $40 million. A talented actor, Schreiber is respected in both the theatre world and in Hollywood. He first started to appear in mainstream productions in the 90s, and today he is one of the most recognizable faces in the entertainment industry. In addition, Schreiber is an accomplished voice actor who has taken roles in a variety of animated films. Liev has won some of his most notable awards as a result of his stage performances.
Liev Schreiber Biography
Early Life: Isaac Liev Schreiber was born on October 4th of 1967 in San Francisco, California. His parents were both artists, and at the age of one Liev relocated to British Columbia with his family. His mother then suffered from a bad acid trip, and she was hospitalized for the next four years. When Liev's mother became convinced that her husband would admit her to a mental institution, she ran away with her young son.
Liev Schreiber Quick Facts
What is the net worth of Liev Schreiber? What is his zodiac sign? Here is Liev Schreiber in a nutshell:
Liev Schreiber Overview
October 4, 1967 (age 55 years)
Actor, Film director, Film Producer, Screenwriter, Voice Actor
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Many are probably wondering about the foundation behind Liev Schreiber's success and wealth. Below we have listed some of the actor's quotes that will get you in the mindset to pursue your financial success.
Hamlet is a remarkably easy role. Physically it's hard because it tends to be about three hours long and you're talking the whole time. But it's a simple role and it adapts itself very well, because the thing about Hamlet is, we all are Hamlet.
Film is such a bizarre vehicle for acting. It's such a bizarre experience. I don't think you ever really get familiar with it. If you do get familiar with it, you're probably not that good anymore.
There's the private persona and the public persona and the two shall never meet.
I think it's really, really important to mix it up as an actor, to try to get as much kind of varied experience as you can, not only for your own personal growth as an actor but for the audience to keep them guessing about what you're going to do.
I think conflicted characters are always more interesting.


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Scott Olson/Getty Images News/Getty Images
Here's How The Obamas Practically Won An Oscar
by Azure Hall
Barack and Michelle have been busy since leaving the White House. Among their many projects, a film production company, Higher Ground, helped the Obamas win an Oscar for American Factory, well, kind of. Higher Ground produced American Factory, and the film won the Oscar for Best Documentary Feature. If you want to be loose with the facts, the Obamas are on their way to an EGOT and no one can tell me otherwise.
OK, the Obamas weren't technically up for an Academy Award this year. Netflix released American Factory under the Obamas' production company, Higher Ground, but the former POTUS and his First Lady were not directly involved in the making of the film. Their names aren't in the credits and they will not receive statuettes, according to CNBC. But, you know what, whatever.
Michelle Obama tweeted out her support for everyone involved in American Factory following its Oscar win. "Congrats to Julia, Steven, and the whole crew on winning Best Documentary for #AmericanFactory, Higher Ground's first release," she wrote. "So glad to see their heart and honesty recognized—because the best stories are rarely tidy or perfect. But that's where the truth so often lies."
While the Obamas haven't officially won an Oscar yet, the power couple have quite a few other awards under their belts, with everything from a Grammy, to an NAACP Image Award, to the Nobel Peace Prize in their trophy room (I'm imagining a room like Timmy Turner's dad has on Fairly Odd Parents with an empty spot for their Oscar) and I have no doubt that an Oscar will make its way there soon. American Factory was only Higher Ground's first release, so there's still plenty of time for my Obama Oscar dreams to come true.
Jan. 17. 2021
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