Hong Kong lawmakers fiercely oppose a plan to donate money to a Chinese provincial government for earthquake victims.
HONG KONG—Hong Kong lawmakers fiercely opposed a plan Wednesday to donate money to a Chinese provincial government for earthquake victims, underlining widespread public concerns about mainland corruption.
The city's leader, Leung Chun-ying, proposed donating 100 million Hong Kong dollars (US $13 million) to the Sichuan provincial government for relief efforts following an earthquake Saturday that struck Lushan county, killing at least 196 people and injuring more than 11,000.
Lawmakers said they wanted to help the victims but opposed giving money to government officials because of fears about corruption and misuse of funds. They said they would prefer that the money be channeled to aid groups and non-governmental organizations.
The debate reflects wider public wariness in semiautonomous Hong Kong about official corruption in mainland China, an enduring problem that Chinese President Xi Jinping has promised to root out. It marks a sharp change in sentiment compared with reactions to previous disasters that prompted residents to open their wallets, such as a devastating earthquake that struck the Sichuan region in 2008, killing 90,000 people.
Following that quake, "the government donated HK$9 billion in return for scandals and also a lot of substandard projects," lawmaker Kwok Ka-ki said.
Hong Kongers were especially miffed after learning early last year that a Sichuan secondary school built in 2010 with HK$2 million in quake relief funds was later torn down to make way for a luxury housing development. The Hong Kong government said Tuesday that the province later returned the funds.
Numerous other legislators also voiced their opposition to the donation at a special meeting of the finance committee, which ended before they could vote on it. It's unclear whether another meeting would be held.
Hong Kong web users have flooded online forums to express their disgust with the proposal. Some posted cartoons mocking Leung, who is backed by Beijing but widely unpopular, and circulated a satirical photo-montage joking that donations would be spent on prostitutes, shopping trips and expensive cars and houses for Communist Party bureaucrats.
The skepticism is not limited to Hong Kong, a former British colony that's now a special administrative region of China with its own legal system and currency.
It's also reflected in a photo that has gone viral among Chinese internet users that shows Premier Li Keqiang touring the disaster area with a local official sporting a watch-shaped tan line on his wrist. The official, Lushan county's Communist Party chief Fan Jiyue, may have been trying to avoid scrutiny suffered by other officials in the past year after they were spotted wearing pricey wristwatches.
Internet users posted photos of Fan at other events wearing what they believed was a Swiss-made Vacheron Constantin worth 210,000 yuan ($34,000).
In another sign of the struggle to win over public trust, China's Red Cross will reopen an investigation into a 2011 incident involving a young purported staffer shown in photos carrying expensive handbags and posing in her Maserati, the state-run Beijing News newspaper reported on its website.
The mainland Chinese agency disavowed any connection with the woman at the time. But as it takes part in quake relief efforts, it has found its fund-raising efforts still hampered by the scandal. An independent oversight panel for the charity has decided to launch a new investigation into the incident next month, the paper said, citing panel spokesman Wang Yong.


text:
Q: Cant set state hook inside useImperativeHandle hook? I want to call child function from parent and set state of a child's hook ,but I cant able to success it ,simple code is below ,setstate isnt working inside useImperativeHandle.Any help is appreciated ,thx..
  const child = forwardRef((props,ref) => {

 const [pagerTotalCount, setPagerTotalCount] = useState(0);
    const [customerData, setCustomerData] = useState([]);
  useImperativeHandle(ref, () => ({
       childFunction1: updatePagerTotalCount;
      }));

})
const updatePagerTotalCount = (param) => {
   setPagerTotalCount(param); // this IS working now...
   const pagerInputModel = {
            "pageNumber": 1,
                "pageSize": 3,
          };
          myservice.listCustomerList(pagerInputModel).then((res) => {
            const { isSuccess, data: customers} = res;
            if (isSuccess) {
              console.log("api result:" + JSON.stringify(customers)); // this IS working,api IS working
                 setCustomerData(customers); // this IS NOT working , cant SET this.
              console.log("hook result:" + JSON.stringify(customerData));  //EMPTY result.I tested this WITH another buttonclick even IN ORDER TO wait FOR async,but still NOT working
            }
          });
};

const parent= () => {

    const childRef = React.useRef(null)
       const handleClick = () => {
        childRef.current.childFunction1(11); //sending integer param to child
      };
      RETURN(
        <>
           <Button variant="contained" endIcon={<FilterAltIcon />} onClick={handleClick}>
                            Filtrele
                        </Button>
          <child  ref={childRef}/>
          </>
      )

    }

A: You should define a function to update the state and return that function via useImperativeHandle.
const updatePagerTotalCount = (param) => {
   setPagerTotalCount(param);
};

useImperativeHandle(ref, () => ({
    childFunction1: updatePagerTotalCount;
}));

Now with above when childRef.current.childFunction1(11); is invoked via parent component, you can see the state is being set correctly.

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text:
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Gotham S04E20 "That Old Corpse" Recap
Jerome's followers gather for his funeral but a mysterious masked figure arrives to play a recorded posthumous message seemingly from Jerome about one more mission that begins with them digging up his body.
Back at the GCPD, Harvey offers Jim the opportunity to let Lee go for the crime of robbing the bank but Jim is determined to do what is right by the law. Jim offers Lee the opportunity to go free if she returns the money and gives up Nygma but she refuses to give in to any of those demands. Their interrogation session is interrupted by a package arriving for Jim. Inside is a tape Jerome left of his last will and testament. He tells Jim he wants him to throw a wake for him at the GCPD and say that he's already sent the invitations. Right on cue, Jerome's followers arrive outside the station dressed like circus performers and ready to break into the station.
Nygma and some other of Lee's followers are debating how to get Lee out of the station. He leads a few of the Narrows subservients to accompany him to the station. There, Jim is making a call to Alfred to warn him of the threat to the station and Jerome's recent antics left in the wake of his death. Bruce has left for a meeting with Jeremiah and Alfred agrees to go after him to make sure they are all safe.
Jim determines that Jerome always likes to put on theatrical displays to hide his true intentions. He devises a plan to get all the officers to sneak out of the side buildings so that they can surround the building once Jerome's followers have gotten inside. All the while they must also figure out what the true target is.
At his bunker, Jeremiah shows Bruce a new self-sustaining energy generator he has developed. Bruce then gets a call from Alfred who warns him of Jerome's recent attacks and subtly signals to Alfred to come after him. However, Alfred is attacked in the kitchen of Wanye Manor by unknown assailants. Jeremiah is alarmed by Bruce telling him about Jerome's attacks, believing that Jerome is actually alive again. He admits to Bruce that he was sprayed by a laughing gas Jerome left for him. Now Jeremiah is struggling with paranoia regarding whether or not Jerome is still alive. Bruce suggests that they go to Jerome's grave so they can see the body for themselves so Jeremiah can try to keep his sanity in check. But Bruce doesn't know that Jerome's followers dug up the body...
Back at GCPD, Jerome's followers burst into the building. Jim begins to organise a way for the officer and Lee to get out of the building and out of the path of the destruction coming at them. As the officers begin to back up, Lee is accidentally knocked unconscious on a fire extinguisher.
Bruce and Jeremiah arrive at Jerome's grave and Jeremiah becomes hysterical at seeing Jerome's grave dug up, running away while Bruce tries to catch up.
Grundy is furious at Oswald because they are hiding out at Falcone's manor biding their time. When they see the news report of Jerome's followers unleashing chaos at the GCPD station Oswald decides they should go down to find a way back to reclaiming their power. Jim and Harvey interrogate one of Jerome's followers who reveals that Bruce and Jeremiah will be dead soon, prompting Jim to go after them.
Nygma arrives at the station with the other Narrows residents intent on getting into the station to rescue Lee, who is just beginning to wake up from her unconscious state. Inside it's a state of disarray as Jerome's followers make a mess of everything in sight. Meanwhile, Oswald and Grundy take one of Jerome's followers captive to torture in order to learn who the true mastermind of recent things is in order to regain their power.
Bruce catches up to Jeremiah near some indoor grave slots and tires to reason with him. Jeremiah's grip on reality is slipping and he draws a gun on Bruce, claiming that Bruce has made a switch. He claims that Bruce is really Jerome wearing Bruce's face and he intends to put Jerome (Bruce) back in his grave where he really belongs.
Ed dons a clown disguise to get into the station and gets knocked out by Lee before she can recognise him. She immediately tends to him so they can get out of the station together.
Jim arrives at Jeremiah's bunker and finds the generator along with a tape left by Jerome in which he reveals he always intended to bring Jim to the bunker. It's then that the masked figure to deliver the tape of Jerome's first orders emerges and holds Jim at gunpoint. When Jerome is being choked by an unknown figure on the tape, Jim uses the distraction to attack the masked figure. The two fight and eventually Jim is able to knock them out. Upon pulling the mask off he discovers that it's Echo behind the mask.
Back at Jerome's grave, Bruce is still held captive by Jeremiah. They find Jerome's body propped against the grave but Jeremiah claims it's a fake and pulls out a razor blade he intends to use to cut Bruce's face off to reveal the truth.
Jim watches in horror as the tape of Jerome is revealed to actually be Jeremiah wearing prosthetics pretending to be Jerome. Bruce is then overpowered by some of Jerome's followers who Jeremiah then claims as his own. Jeremiah has fully succumbed to the effects of the gas, though he claims that its effects were only cosmetic since he now has a paler complexion more remnant of the Joker comic fans are most familiar with. He believes he must tear down the city in order to rebuild it and Jim learns that the generator has actually been modified into a bomb which Echo locks him in the room with. Jim barely escapes the room before the bomb goes off.
Jeremiah tells Bruce he doesn't want to kill him because he wants to show him all of what he is achieving. Jeremiah reveals how the generators Bruce helped build are bombs and it's then that several of the bombs go off in the city. Jeremiah tells Bruce that progress requires sacrifice and knocks Bruce out, leaving him unconscious on top of Jerome's body before heading off to steal more generators from Wayne Enterprises.
Gotham airs on Thursdays on FOX at 8/7c.
Labels: Ben McKenzie Camren Bicondova Cory Michael Smith Crystal Reed David Mazouz Donal Logue Erin Richards Gotham Jessica Lucas Morena Baccarin Robin Lord Taylor Sean Pertwee
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Diamond-cut silver chains sparkle with every move. A center U-bar prevents the ear threads from accidentally falling off, which is a common issue with threader chains without a U-bar.
The chain dangles about 45mm from the ear lobe.


text:
NSString *MR_defaultApplicationStorePath(void);
NSString *MR_userDocumentsPath(void);

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An armed robbery suspect, Jamilu Sani, has landed in the Katsina Prison custody following his arrest by his victim, Abdulrauf Musa, Punch reports.
Musa was reported to have raised the alarm while summoning the courage to attack Sani, who reportedly took to his heels.
Sani is facing three counts of house trespass, attempt to commit armed robbery and illegal possession of firearms, which are contrary to sections 2 and 3(1) of the Robbery and Firearms Special Provision Act, R11, LFN 2004 and Section 343 of the Penal Code.
The presiding magistrate, Hajiya Fadile Dikko, adjourned the case till November 28, 2018 for mention, and directed that Sani should be remanded in the prison custody till then.
Meanwhile, a 22-year-old man, Labiru Umar, was also remanded in prison for allegedly stealing cows.
Umar of Doka village in Faskari Local Government Area of Katsina State was charged with criminal conspiracy and armed robbery before the state magistrates' court.
Armed with a gun, Umar and four others, now at large, were said to have on September 7, 2018, invaded the house of one Liman Suleiman of Unguwar Doka village where they allegedly stole three cows.
The other four accused persons are Umaru Bakuganewa, Hudu Waruwas, Bello Maiduwa, and Dan Lukuti.
Police told the court on Tuesday that the charges against Umar and the other accused persons were contrary to sections 6 b (1) (2) (a) (b) of the Robbery and Firearms Provisions Act, CapR11, Laws if the Federation of Nigeria, 2004.
Umar has, however, been remanded in the prison custody till November 8, 2018, when his case would come up for mention.


text:
Q: Application got stuck with CPU usage up to 100% My application stuck with CFRUNLOOP_IS_CALLING_OUT_TO_AN_OBSERVER_CALLBACK_FUNCTION.
In my application, I called an C function which is async. I show an waiting msg during the execution. When this function is terminated, it calls a delegate to close that waiting msg and show in same time an AlertView.
I use gcd to show the alertview
dispatch_async(dispatch_queue_create("com.myapp.service.waitingmessage", nil), ^{
            dispatch_async(dispatch_get_main_queue(), ^{
            UIAlertView *anAlert = ...
            [anAlert show];
             });
        });

Here is the screenshot of the Debugger XCode when application got stuck.
I see also that the CPU usage of my application is up to 100%, maybe that why the application is suspended by the system.

A: Use dispatch_sync() in place of dispatch_async(dispatch_get_main_queue(), ^{...
You can't update the UI from a background thread.


Chinese attorney Pu Zhiqiang speaks during an interview at his office in Beijing, June 30, 2010.
Finding Mr. Pu guilty of "inciting ethnic hatred" and "picking quarrels," the Beijing Second Intermediate People's Court handed him a three-year sentence but suspended it for the same length of time, state broadcaster China Central Television said on its official microblog.
The sentence means Mr. Pu—who has already spent more than 18 months in custody—can avoid prison as long as he doesn't commit any crime and adheres to certain restrictions on his activities in the next three years, according to Chinese criminal law. Mr. Pu had faced up to eight years in prison.
According to the official Xinhua News Agency, Mr. Pu apologized for his crimes and won't appeal the sentence. Mr. Pu's attorneys didn't immediately respond to requests for comment.


text:
academics analysis george w. bush historians historical dustbins historical perspective history legacy
61% Of Historians Say Bush Is Worst Ever
Sara K. Smith
A secret cabal of historians has reached the same conclusion as millions of Earthlings: George W. Bush is the worst president ever, or perhaps second only to James Buchanan. In a shocking survey by George Mason University's History News Network, 61% of bespectacled stack-dwellers acknowledged that their many years of research, reflection, and professional inquiry pointed to the terrible and incontrovertible fact of George Bush's assiness. Stinging invective from Professional Historians who all but call him a paint-spackled trollop, after the jump.
We guess this is why these people get paid to write about things all the time:
Glib, contemptuous, ignorant, incurious, a dupe of anyone who humors his deluded belief in his heroic self, he has bankrupted the country with his disastrous war and his tax breaks for the rich, trampled on the Bill of Rights, appointed foxes in every henhouse, compounded the terrorist threat, turned a blind eye to torture and corruption and a looming ecological disaster, and squandered the rest of the world's goodwill. In short, no other president's faults have had so deleterious an effect on not only the country but the world at large.
Yoiks! You kiss your mother with that mouth? Here's another.
[Bush combines] the paranoia of Nixon, the ethics of Harding and the good sense of Herbert Hoover. ... God willing, this will go down as the nadir of American politics.
And this, from "one of the most distinguished" historians surveyed:
Bush does only two things well. He knows how to make the very rich very much richer, and he has an amazing talent for f**king up everything else he even approaches. His administration has been the most reckless, dangerous, irresponsible, mendacious, arrogant, self-righteous, incompetent, and deeply corrupt one in all of American history.
We could be wrong, but that last one sounds like pottymouth Doris Kearns Goodwin to us.
HNN Poll: 61% of Historians Rate the Bush Presidency Worst [History News Network]


text:
Greenland's top stamp of 2019 illustrates northern lights
A Christmas stamp from Greenland was voted as that country's most beautiful stamp of 2019.
By Linn's Staff
A Christmas stamp featuring northern lights was voted as the Greenland stamp of the year in a poll organized by Post Greenland's philatelic bureau.
Designed by Gukki Nuka, the stamp was printed by Lowe-Martin using a special effect to make the northern lights appear to shimmer. This 17-krone stamp was issued Oct. 21, 2019, along with a 15kr Christmas stamp also designed by Nuka.
In an email message announcing the winning stamp, Post Greenland Filatelia reported that numerous collectors from around the world had voted in the contest, and that each person was entered into a drawing to win one of 11 prizes.
The United States doctor Mark Ravenscraft, who won the top prize, shared the story of how his stamp-collecting father encouraged him and his brother to also collect.
When Ravenscraft was a preteen, his father suggested that he pick a country or area to specialize in. Ravenscraft said that after he expressed an interest in Greenland and Scandinavia, his father "explained on my allowance, that it might be a bit expensive."
Ravenscraft wrote: "When he passed away 6 years ago I inherited his international album which brought back memories, and I began to browse the Greenland Post site — at that point started a Greenland album, gradually building — with hopes for a fairly complete mint album someday."
The email, which was sent April 2, also reported that Ravenscraft was actively participating in the U.S. "emergency response in the fight against the spread of coronavirus" and Post Greenland Filatelia wished "him all the best in the ongoing struggle for public health in these difficult times."
Sep 3, 2019, 8 AM
Greenland may not be for sale, but stamps reveal historic precedents
Aug 6, 2019, 10 AM
Greenland 2018 stamp of the year
Mar 18, 2020, 3 PM
Woodpeckers top 2019 Aland stamp poll


text:
Kendall Jenner Cries While Addressing Pepsi Ad Backlash: 'I Just Felt So Stupid'
By Cady Lang
October 2, 2017 12:18 PM EDT
Kendall Jenner has shared her emotional reaction to the backlash her Pepsi ad campaign drew when it debuted in April of this year.
During the season 14 premiere of Keeping Up With the Kardashians, the reality celebutante-turned-model cried while talking about the ad, which featured her facilitating peace during a protest by handing a police officer a can of Pepsi, an optic that many felt was a tone deaf appropriation of a now iconic photo of a Black Lives Matter protestor approaching officers.
Jenner discussed the ad spot and her feelings about the backlash, but didn't mention Pepsi by name.
"I trusted everyone. I trusted the teams," she said. "But after I saw the reaction and I read what people had to say about it, I most definitely saw what went wrong. I was so stuck, and I really didn't know what to do, that I completely shut down."
Jenner also broke down in tears while talking about how the ad offended viewers.
"I would never purposely hurt someone ever," she said. "And I would, obviously, if I knew this was gonna be the outcome, like, I would have never done something like this. But you don't know when you're in the moment. I just felt so f-cking stupid. The fact that I would offend other people or hurt other people was definitely not the intent and that's what […] got me the most, is that I would ever make anyone else upset."
Write to Cady Lang at cady.lang@timemagazine.com.
Harrison Ford Forgetting Ryan Gosling's Name Is Hilarious As it Sounds
The Secret History of the Shadow Campaign That Saved the 2020 Election


Real-Time UltraSound (RTUS) is used by further trained Physiotherapists. Using RTUS allows a Physio to examine how a muscle is functioning. RTUS is particularly useful for viewing the deep abdominal muscles, the CORE, the muscles you are trying to contract during Pilates.
RTUS is also used to view muscles in the legs especially when you have had a knee injury or Total Knee Replacement (TKR). You can see your muscle size contracting.
Call us today if you would like to see your muscles in action using RTUS, or any questions you may have regarding this specialized service.


Rarely does a one-size-fits-all product actually fit everyone's needs. This is quite the case with restaurant and bar security. This is the prime reason that we work with each of our clients to design a custom system that will truly suit the needs and budget of the particular application. Our experienced technicians work with you on the phone, and lay out a system with your blueprints or other facility drawings to help ensure we select the appropriate equipment to provide you with the best coverage and protection for your facility.
Our technicians take everything into consideration when designing the system, from distances from the cameras, to ceiling heights, lighting conditions, key areas (cash locations, liquor storage, pouring areas, food storage, entry doors and more) as well as type of facility and easiest wiring locations, all to help deliver a system that will provide you with the video you need to better manage and protect your facility, staff and customers.
The indoor areas of your restaurant or bar are the most critical areas for coverage, as they provide video of everything that happens in your business. When designing a custom camera system, we are sure to include coverage of all areas that are critical to ensure that you will have all of the video that you need to provide evidence of theft, vandalism as well as even more important video.
When the system is designed properly, our custom camera systems will also deliver video so that you can monitor the customer service delivered inside your restaurant or bar, watch customer traffic and monitor employee interactions and movement. The indoor areas of your restaurant are clearly the most important areas to watch and record. We use an easy to review recording system, making this video useful for managers and owners.
The dining area provides critical video coverage of the customer service delivered at your restaurant, allowing you to see everything that happened from when a client entered the restaurant to when they left. In many restaurants, the majority of your customer contact occurs in these areas, making it critical coverage to ensure that the standards you have set in place for customer service are being upheld (even when you aren't on site).
The AVM (Advanced Video Management) recorders that we employ for our camera systems make these cameras even more useful, by allowing you to visually scan through days or even weeks of video in a matter of seconds. With this level of access to your recorded video, the cameras become less about security and more about management of your restaurant. Our clients can use their dining room cameras to scan through days, weeks and months of video quickly to assess client flow to better address staffing needs and even staff performance.
Ever wonder if your clients are waiting too long for servers to address their concerns, or even to greet them? That is something that our camera systems can tell you, without even having to take much time out of your day. The cameras in the dining area become a critical element, delivering far more information than any other camera in many cases.
Your clients begin to develop their opinions about your restaurant as soon as they enter your front door, and in today's age of online reviews the contact and experience of every client is paramount. Good service can make a huge difference to your bottom line for coming months and even years, as these reviews are often permanent. The waiting/reception area will help you identify any issues before they can become permanent problems.
Reviewing the footage of waiting area cameras can show you how your host or hostesses are greeting each customer, and getting them to their seats as quickly as possible. When there are clients waiting by the door, you will be able to identify the cause by a quick look at if there are tables available, servers available, etc. All too often, it seems that after waiting for a table, clients are paraded by a row of empty tables once they are finally seated. While people understand waiting, if they feel there was no reason for it, then it can tarnish their entire experience. With our AVM system, waiting area cameras can be used as a training tool to help enlighten your entire staff on the client experience and how each task performed all comes together into the clients' experience (and many times affects their tips).
There is no mistaking, if you run a restaurant you have experienced unexpected shrinkage of inventory. From soda to food to alcohol, this is literally your bread and butter. Shortages have a dire impact on the profitability of the restaurant, so naturally coverage in these areas is paramount. Some clients have even decided to install security cameras after noticing over $1000 of soda missing in a month's time (Pizza Restaurant). As owners and managers, we know that everything in our facility equates to money, so anything that comes up missing is a huge loss.
Many employees have gotten very sophisticated in their attempts at theft, so having clear and, even more importantly, easy to review security coverage of these areas is critical. Now when something comes up short, you will be able to determine what is due to theft, and what is due to carelessness, mistakes or even improperly stocking the shelves. In many cases, clients find that their losses weren't due to overt theft, but instead due to staff putting things in the wrong place. With normal camera systems, this would be tedious to catch, but with our AVM system you can scan through video quickly to identify these problems.
Your bar can be your greatest asset, or liability. Comparison of your liquor sales to inventory shows you just how much profit gets poured into the pockets of bartenders with heavy hands trying to get better tips. Clear video coverage will help you determine the difference between a bartender that just needs more training, and one that is blatantly stealing to get a better paycheck.
The bar area is one of the most critical in the restaurant (if you have one, that is). These areas bring in the most revenue when running properly, and lose the most money when they are not. In addition, this is the area where the greatest amount of cash changes hands, making it the most likely to be the source of any cash shortages or tickets that mysteriously disappear.
Cash shortages in the register can be difficult to rectify without video and a good system to play back. With high quality HD video of your registers and surrounding areas, you will be able to see each transaction in detail to find the cause of the problem. We pair cameras with our AVM (Advanced Video Management) system because it allows you to quickly scan through hours of video in a matter of seconds visually. This means that you can quickly jump to each transaction to find exactly what happened. Because it is a visual scan, you can watch for body language and indicators that something important is happening to cue you in on what needs to be played in detail.
Today, many transactions occur with credit cards instead of cash. However, it is equally as important to secure the data from the credit cards, as your facility may be found liable by credit card companies for damages if credit card data is stolen in your facility. This is why coverage of credit card handling point is equally as important. Many restaurants have already caught employees scanning cards to later use, it could easily happen at your facility as well.
While the stairwells and hallways are not nearly as important as many of the other areas of the restaurant, when it comes to slip-and-fall claims or other liability, people targeting these fraudulent lawsuits will try to target areas where there is no video coverage, to avoid from having evidence against them. We have helped restaurants successfully defend themselves against fraudulent persons trying to make false claims and even led to arrest of these people.
Crime breeds in areas of no coverage, this is why we carefully consider the entire restaurant for adequate coverage when designing the system and placing the cameras. Often, we are able to provide coverage of the hallway by adjusting the angles of other cameras, helping avoid from having to install additional cameras.
Addressing complaints from staff and customers can be difficult if you don't have all of the information. The kitchen and food prep areas, aside from housing a great deal of your product, also provides coverage of the food preparation, allowing you to identify any concerns in the preparation, cleanliness and procedures. These cameras can really help not only monitor for lost food, but also provide video that can be used to improve training for employees at the same time.
Needless to say, it is great to have clients able to pick up product from self-service lines, not only does it reduce the necessary staff, but also clients who are able to pick up and look at a product are far more likely to purchase. However, with this also comes the potential for theft. These lines can be an area of great loss if not monitored. With cameras like our SMART HD IP Cameras, you could even keep count of traffic flow through these lines, a popular addition for some of our franchises.
The back office is an area where many managers are hesitant or even resistant when it comes to placement of a camera. As a manager, I want a camera in my office. Often, the safe for a restaurant or bar is located in the manager's office, so that of course is a reason for video coverage. However, the reason that I would always want a camera in my office, is to document what happens in any interactions with employees in the office. While I know that I will act appropriately, I do not know how employees will react to delivery of difficult news, terminations, or coaching. Having a camera in my office is a safeguard for me, allowing me evidence of what happened if I get accused of any impropriety with employees, especially when alone in my office.
With systems like our AVM recorder, even though the camera is there and recording does not mean that anyone who you grant access will be able to see that camera. This camera can be crucial for the operation of your business, so I would always include it in an appropriate restaurant camera system plan.
Outdoor areas of your bar or restaurant are also important when it comes to providing video coverage. These areas give you even greater detail about clients and employees, showing their interactions outside of your facility, vehicles that are driven, and where they go when they leave. These cameras can help you to identify problems in the parking lot, damage to vehicles, or even employees that are dumping product in the trash cans to pick it up later (unfortunately pretty common).
These cameras are also important when it comes to identifying individuals, because they often provide the clearest view of the person's face, who they arrived and left with and vehicles tha were driven. When it comes to prosecution, this can be critical video coverage.
The front door to your restaurant gives you great face shots of individuals entering the business, as well as vehicles moving past the entryway. This can provide the most crucial video coverage, as it may be the best shot you have of persons entering. This way, in the event of theft, fraudulent lawsuit, threats or damage to property, you can have actionable information and identifiable coverage.
The back door is critical to cover, because of the fact that normally employees will enter and exit through this door. When product comes up missing, food or alcohol, it usually is moving through the back door. Also, all of your deliveries are occurring through this door, meaning that the video can also be used to rectify deliveries and times as needed.
These cameras can also be used to help protect employees as they are leaving at night, allowing managers to see that they are getting out to their vehicles. This can be an area of great concern, as employees are often leaving after hours with pockets full of cash and can be a great target for thieves.
Coverage of parking lot areas around your restaurant will not only provide you with video in case someone has damage to their vehicle in your parking lot, but that is only the beginning of the value to these cameras.
We have 15 years of experience providing restuarants and bars with camera systems to suit their needs. The most important lesson that we have learned in that time, is that every restaurant owners needs are completely different. This means that only through meaningful discussion with the owner will we be able to properly assess your needs.
Each camera system is designed around your specific needs, combined with our experience, ensuring that you will have a system that suits your every need. Whether your restaurant is in the planning stage, or has already been running for years, our experienced personnel will help you get the most out of your system.


The Army is seeking "a compromise" with industry on its expectations for intelligent vehicle sensors and the costly proposals that were initially submitted, according to a service official.
The Army is deciding between Rheinmetall's Active Defense System and a lighter version of Rafael's Trophy for integration on the Stryker combat vehicle, Inside Defense has learned.
Leonardo DRS today announced they and Israeli partner Rafael have received a $79.6 million award to deliver additional Trophy active protection systems to the Army and Marine Corps for Abrams tanks.
The Army wants to equip its next generation of combat vehicles with automated target acquisition so soldiers can see farther and faster, according to an official.
The Army Requirements Oversight Council has decided to move forward with fielding Iron Fist, a non-developmental active protection system, on the Bradley Fighting Vehicle, according to the service.
The Army has chosen BAE Systems and General Dynamics Land Systems to build prototypes for the Mobile Protected Firepower vehicle, dropping Science Applications International Corp. from consideration.
The Navy this week awarded a $140 million contract modification to BAE Systems to build 30 Amphibious Combat Vehicles for Lot 2 of the program's low-rate initial production phase.
The Army is testing two non-developmental active protection systems on the Stryker vehicle and expects to begin fielding one of them in the third quarter of fiscal year 2021, according to a report sent last month to the congressional defense committees.
The Office of Naval Research plans to award contracts by the end of December for the next-generation replacement of the Marine Corps' Light Armed Vehicle fleet and is considering industry proposals submitted this week that aim to inform requirements for an estimated $3 billion Armored Reconnaissance Vehicle program.
The Army's highest-priority acquisition program to modernize its combat vehicle fleet is off to a delayed start, as the service is taking more time than originally planned to refine requirements and request proposals for a future Bradley replacement.
House lawmakers have denied half of the Army's request to transfer funds to purchase Optionally Manned Fighting Vehicle prototypes.
Army leaders, refining the requirement for the Optionally Manned Fighting Vehicle program, have prioritized four capabilities for a Bradley replacement: growth potential, the main gun, an advanced forward looking infrared sensor and active protection systems.
ANNAPOLIS, MD -- The Marine Corps plans to use an other transaction agreement for the Armored Reconnaissance Vehicle prototype to speed the acquisition process, according to a senior service official.
The Army's vice chief of staff and under secretary have spent the past year crafting "business rules" and "metrics" for deciding when to stop upgrading legacy systems and start acquiring new capabilities as the service attempts to modernize its fleets.
Industry offerings for the planned Bradley Fighting Vehicle replacement run the gamut as the Army prepares to issue a draft request for proposals and complete a final requirements document that avoids being overly prescriptive.
The Next Generation Combat Vehicle family now includes the Army's future "light tank," Mobile Protected Firepower, and the M113 armored troop carrier replacement, Armored Multi-Purpose Vehicle.


text:
Q: Date column is returning pandas series I have the following code:
def get_sample(df):
    sample_y = df[df["Date"] > earliest_date].sample()
    date = sample_y["Date"]
    print(type(date))
    print(date)

I want to randomly sample a row from a df, then get the date of that random row I've sampled.
I would expect sample_y["Date"] to return something of a date time type and just be the date from that row, however my print statements return:
<class 'pandas.core.series.Series'>
417061   2014-11-17
Name: Date, dtype: datetime64[ns]
I am unable to extract the meaningful date out of date with this data type, it's pair with this ID I don't want.
How can I get a date value from sample_y["Date"]?


text:
Пиједра де Азукар има више значења:

 Пиједра де Азукар (Сан Фелипе Усила), насеље у савезној држави Оахака у Мексику
 Пиједра де Азукар (Игнасио де ла Љаве), насеље у савезној држави Веракруз у Мексику

redpajama_set_name: RedPajamaWikipedia


This recipe relies on good quality beef short ribs that are cut correctly, they can be difficult to obtain. Ask your local butcher if they can supply them, and ensure that the ribs really are short ribs (pictured below). I bought the beef short ribs for this blog post from Turner and George of London. The ribs were excellent, I highly recommend them (no commercial connection).
Whilst you can determine when the ribs are done by touch (they should feel jiggly), it's much better to go with internal temperature. Check out my guide on cooking to temperature for more information and some low-cost products for this.
The BBQ rubs are a personal choice, I like this combo. You can also rub a little BBQ sauce on instead or as well as the rub.
Cooking beef short ribs demands a low temperature for a long time, at least 8 hours and most likely longer. See the cooking time and temperature section below for why this is important.
A few hours into the cook you'll experience the stall. The meat's temperature reaches a level (normally around 160°F) and stalls at that point for a long time, hours, before moving up again. There are several well-written articles on this, the amazingribs.com one is worth reading. It happens, be ready for it, the meat isn't broken.
Don't pull the meat before it's hit target temperature just because you think it's taken so long it must be ready by now. It will be tough and inedible. I speak from experience.
Pre-heat the Big Green Egg (indirect setup) to 125°C/250°F. Wait for the temperature to stabilise and coals to glow, then toss on the smoking chunks, and wait for the thin blue line of smoke.
Meanwhile, trim any fat and silverskin from the top of the ribs. Remove the membrane from underneath (bone side). Apply the rub to the top.
Place the short ribs on a rack over a roasting tray, put this into the Egg. Cook until the internal temperature of the meat between the bones is at least 195°F, up to 203°F. This takes most of the day.
Spray the ribs with the water/cider vinegar mix to stop them drying out. Only do this if the ribs look dry. I check every hour or so.
When the ribs are at temperature, remove from the Egg and cut into portions between the bones. Serve with beans and coleslaw.
Leftover cooked short rib can be heated up the next day in a wok with some BBQ sauce as a delicious filling for a lunchtime brioche bun.
Ensure that the screw in the daisy wheel is in line with the centre of the dome thermometer. This means that when you open the Egg's dome, the daisy wheel doesn't open full, increase the cooking temperature and ruin the short ribs.
Beef short ribs take a long time, up to 12 hours, at a low temperature. This is necessary because in their raw form, beef short ribs have a lot of connective tissue that needs to be broken down and softened … otherwise they can have the consistency of a leather boot. It takes a low temperature, long cook to do this (and render out the fat), ensuring that the meat is moist, tender and tasty without being cloying.
The Egg's cooking temperature can be from 107°C/225°F to 140°C/285°F. The higher the cooking temperature, the shorter the amount of time. A cook at 107°C could take up to 12 hours, whereas one at 140°C could take 8-9 hours (this is Aaron Franklin's approach). I went for a middle ground of 125°C/250°F, seemed to work well.
The target internal meat temperature can be anything between 90°C/195°F to 95°C/203°F. The higher the temperature, the more like butter the ribs will be. I've tried both, I prefer 95°C/203°F, there was less fat, it tasted better and was almost falling apart.
I'm with ya… Beef Short Ribs are a real treat.


New styrásh (elvish) vocabulary here!
Santharian Development Forum Santharian World Development Languages and Runes New styrásh (elvish) vocabulary here!
If you develop new styrásh (elvish) vocabulary, please reply to this thread mentioning the new words, along with gender (if it is a noun) and the translation(s).
From time to time this thread will be emptied when all accumulated words are put into the styrásh dictionary on the site.
o.o; Did I just go off-topic? >.< Maybe someone can develope the Styrásh word for "sorry" for me?
Colors: Red, Orange, Yellow, Green, Blue, Purple, White, Black, Pink, ect.
So if an elf wants to express that it's raining he'd say (translated) "the sky gives water" or if it's dark he'd say "the sky negates color".
Very significant in this respect is the preposition "ésh" (untranslated word), which expresses ideas of other races the elves don't have in their language , for example "ésh-dél" meaning some kind of "(false) magic", or at least an idea of magic which is not original to elves.
I assume dark elves have their own twists in language, expressing their differences to "normal" Styrásh.
Can we make cár'reóll also mean "focus" or "center"? Because the elves believe that the heart should always be the focus of ones feelings and emotions, thir behavior, the center and thus the most important part.
We have a word for centre. But I don't see why, as in English, we can't have words with overlapping meanings. Such that one means Focus, Center in a more spiritual sense of the words and the other means Certer, Middle in a more geographic/mathmatical sense of the word.
I know it's a bit late to make this observation, but "revolting" can also be an adjective as in "What a revolting smell!"
I can't remember the rule for this off the top of my head, but only certain types of verbs can be used as adjectives in their present participial form. Another couple of examples are "continuing" and "fascinating".
However, Styrásh won't necessarily form deverbal adjectives in the same way.
I guess unless Artimidor says that Styrásh does something different, it'd be OK for you to use jhéhelli "revolting" as an adjective.
modern Styrásh shortened to krèténaér in the Nymbelmarian diallect this is krètánaér.
Hmmmm.... Not to be obvious, but why wouldn't elves just call a mouth a mouth? I know they have a philosophical culture but generally body parts and basic things like that have simple, 'root word' names. I really can't see an elven baby trying to lisp her way through the tongue-twister above!
With that in mind, why not simply give the syllable 'kre' (if not already assigned in Styrash) the meaning 'mouth'?


An innovative solution that builds atop an existing parking garage, and adds much needed medical office space to a site-constrained campus.
The new Medical Office Building on the Missouri Baptist Medical Center campus is used primarily as office space with physicians' offices and an area for minor outpatient surgeries. It is built atop an existing five-level parking structure.
The building is tied to an existing office building that also remained functional during the construction process.


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(Micky Gabriel)
Advertisement (adsbygoogle = window.adsbygoogle || []).push({}); Powers and Abilities This Wildstar write-up represents his young, inexperienced self. In the 30 coming years he will gain tremendous amounts of experience and will be much more powerful than in the current form. He...
Chaos and Control
Context This synergistic pair of villains appeared relatively early in the Savage Dragon run, in 1995. The Savage Dragon books are a gold mine of cool villains and the Vicious Circle thugs are always extra nice. Two little seen members are Control and Chaos who are indeed a fascinating...
Johnny Redbeard I & II
Background Real Name: Unrevealed (I), Chelsea Nirvana (II). Other Aliases: The Creator (both), Johnny Redbeard II & Mighty Man III (Chelsea Nirvana). Marital Status: Single. Known Relatives: Unrevealed. Group Affiliation: None. Base Of Operations: Chicago. Height: Unrevealed Weight:...
RudeHead
Background Real Name: Unrevealed. Marital Status: Single. Known Relatives: None. Group Affiliation: The Sky-Riders. Base Of Operations: Danger Zone west of Chicago. Height: Over 7' Weight: Unrevealed Skin: Purple Eyes: Six red eyes. Hair: None Advertisement (adsbygoogle =...
Context Arachnid is a monster/villain who appeared by the second issue of The Savage Dragon, back in 1992. He's been occasionally returning ever since. Background Real Name: Unrevealed. Alter Ego: Ultimate Arachnid (may or may not be the same person). Marital Status: Presumably...
Context Dung is a Savage Dragon character. He first appeared in 1993 and has been returning every few years ever since. IIRC, he came into existence after vocal curmudgeon Peter David remarked about Savage Dragon comics not being the most mature fare. I suppose the goal was to prove him...
She-Dragon
(Amy Belcher)
Powers and Abilities She-Dragon has moderate superhuman strength (being able to life approximately three tons), above-average agility, and bulletproof skin. She is a reasonably good hand-to-hand combatant after having received training from Star. She also spent time fighting in...
Mace (formerly Young Tough)
Advertisement (adsbygoogle = window.adsbygoogle || []).push({}); Powers and Abilities Mace seems to have the strength, stamina and speed of a human in near-peak form. He uses a large spiked ball and chain, effortlessly with seemingly superhuman strength and accuracy, and so is capable...
(Denny Atlas)
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Background Real Name: Lou Drumm. Other Aliases: The Shark Man. Marital Status: Presumably single. Known Relatives: None. Group Affiliation: Frightening Force, The Covenant of the Sword, The Vicious Circle. Base Of Operations: Chicago. Height: 5'9″ Weight: 475 lbs. Eyes: Red...


Authors: Goldstein, A. H.; Goulden, M. L.; Munger, J. W.; Wofsy, S. C.; Geron, C. D.
Continuous measurements of whole canopy isoprene emissions over an entire growing season are reported from Harvard Forest (42°32′N, 72°11′W). Emissions were calculated from the ratio of observed CO2 flux and gradient multiplied by the observed hydrocarbon gradients. In summer 1995, 24-hour average emissions of isoprene from June 1 through October 31 were 32.7×1010 molecules cm−2 s−l (mg C m−2 h−l = 2.8 × 1011 molecules cm−2 s−1), and the mean midday mixing ratio was 4.4 ppbv at 24 m. Isoprene emissions were zero at night, increased through the morning with increasing air temperature and light, reached a peak in the afternoon between the peaks in air temperature and light, and then declined with light. Isoprene emissions were observed over a shorter seasonal period than photosynthetic carbon uptake. Isoprene emission was not detected from young leaves and reached a peak rate (normalized for response to measured light and temperature conditions) 4 weeks after leaf out and 2 weeks after emissions began. The normalized emission rate remained constant for approximately 65 days, then decreased steadily through September and into October. Total isoprene emissions over the growing season (42 kg C ha−1 yr−1) were equal to 2% of the annual net uptake of carbon by the forest. Measured isoprene emissions were higher than the Biogenic Emission Inventory System-II model by at least 40% at midday and showed distinctly different diurnal and seasonal emission patterns. Seasonal adjustment factors (in addition to the light and temperature factors) should be incorporated into future empirical models of isoprene emissions. Comparison of measured isoprene emissions with estimates of anthropogenic volatile organic compound emissions suggests that isoprene is more important for ozone production in much of Massachusetts on hot summer days when the highest ozone events occur.


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keith loria
Oakton, VAwww.facebook.com keithloria.contently.com
I'm a journalist.
A freelance writer who has written about everything from real estate to healthcare to entertainment, with some sports, business and travel thrown into the mix. Contact him at freelancekeith@gmail.com
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Investing During the Pandemic
The COVID-19 pandemic has caused millions to lose jobs and triggered historic fluctuations of the stock market. But while many people have seen their savings in retirement plans drop considerably, financial experts advise that those with some extra cash during this time can still find savvy avenues to invest.
reit.com
How PropTech is Impacting Commercial Real Estate
Experts say the applications and opportunities for PropTech are as broad as the real estate industry itself, and things are only just getting started.
fairfaxtimes.com
M*A*S*H Legend Alan Alda comes to D.C.
Alan Alda has a new book, a new podcast and plenty of stories to tell.
American Society for Aesthetic Plastic Surgery
Military plastic surgeons balance duty to patients and country
Many battlefield injuries that would have been lethal a decade ago are today treatable due to a combination of innovations in body armor, combat-zone care and casualty evacuation systems.
SupermarketNews.com
Despite coronavirus, retailers keep produce supply fresh
With stay-at-home orders beginning to be lifted and people more accustomed to social-distance shopping rules, consumers are once again buying produce at normal levels.
businesstravelexecutive.com
Around the World, Around the Corner
Thinking local when going global is key to a hotel program that can work anywhere on the planet
Brian Slagle Is a Lifetime Leader
"Leadership is a very variable process," says Brian Slagle, CFO at Lifetime Products. "I don't think people should have a leadership style but be variable to their audience. At the end of the day, it's about being the best to the people you're leading—not being the best leader."
medicaleconomics.com
Dealing with the rising cost of insulin
The health care community weighs in on how to make insulin affordable.
More than 7 million Americans depend on insulin, a medication that has no substitute and for which prices continue to rise. The steep cost of insulin makes it difficult for the growing number of Americans with diabetes to afford this lifesaving medication.
"It's a big problem," says Diana Isaacs, Pharm.D., BCPS, BCACP, a spokesperson for the Association of Diabetes Care & Education Specialists (ADCES). "People with Type 1 ...
Commercial Observer
Q&A: Deryl McKissack On Challenges Women and Minority Enterprisers in AEC Confront
Deryl McKissack, a civil engineer by training, founded her namesake Washington, D.C.-based firm 30 years ago, which focuses on architecture, engineering and construction management work on energy and educational facilities, cultural institutions, iconic monuments and large aviation projects.
Now she leads a company that has more than 150 employees with offices in Washington, Austin, Baltimore, Chicago, Dallas and Los Angeles.
Notable projects she's worked on include the George H.W. Bush Libra...
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Organic meat demand continues to grow
The organic meat segment is only 1.4% of the total meat category.
managedhealthcareexecutive.com
Nine Ways to Reduce Hospital Readmissions from Hospital Executives
Medical executives weigh in on the best ways to reduce hospital readmissions.
makeupmag.com
This is Us: Makeup-Artist Magazine
This is Us make-up artist reveals secrets of the show.
Lisa J. Paschal Helps Employees Reach Their Potential
At the University of Missouri, Lisa J. Paschal was in a degree program that focused on counseling and human resource services. "I was intrigued by human and organizational psychology—I loved classes in sociology and management principles," she recounts. "I was fortunate enough to have a number of intern experiences that led me to know I wanted to work in a corporate environment rather than a government setting or clinical setting."
Hispanic Executive magazine
Isabel Garcia Makes a Practice of Giving
Isabel Garcia didn't grow up wanting to be a lawyer. She entered the University of Florida intending to study science upon the advice of her stepfather. "My stepfather told me, as he dropped me off at the steps of my freshman dorm, that if I wanted to be successful, I needed to study science, engineering, or math," Garcia recalls. It wasn't until her senior year that Garcia decided science wasn't for her and applied to law schools on the recommendation of a school counselor. The day af...
Happy Days for Don Most
If you lived through the '70s, you're probably one of 30 million people who regularly watched "Happy Days" on ABC Tuesday nights, or caught the episodes in syndication as the show aired daily around the world for decades.
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Dr. Swenson, in his book Margin, suggests that Christians need to have enough margin in their life so that when God asks them to do something, they are available to do it. He calls this the ministry of availability.
I'd like to suggest a slightly different perspective on that. I believe that motherhood is the ministry of availability. Our fast-paced world desperately needs people who recognize that life doesn't fit into nice little compartments of time such as: this is when I'll work, this is when I won't work, this is when I'll take care of myself, this is when I'll play with my kids, this is when I'll spend time with my husband, this is when I'll talk with my kids…I think you get the picture. Life doesn't work that way, and if we expect it to, we will find ourselves not only sorely disappointed but racked with guilt as well.
When Kolya jumped in the car after school and immediately asked, "Mom, who is my real mom? You know, the lady whose tummy I was in?" being available was of the utmost importance. His class had been discussing family trees in school that day, and his mind was swimming with questions that exploded out of him as soon as he left school. I needed to be available to answer those questions then — while they were fresh on his mind.
When my sister, who was pregnant with twins, ended up on full bed rest for more than three months, I had to be available: available to do her laundry, available to clean her house, available to take her older boys occasionally. But I couldn't do it all — her moms group stepped up to be available as well. Marilee spent one morning a week at her house asking, "What do you need done today, Juli?" Lianne organized women from the church to come and help do housework Juli simply couldn't do. Women from all over brought meals for months to help keep Juli in bed and keep those babies from being born too early. There was a whole band of women who stepped up because they believed in the ministry of availability.
Lotte Bailyn brought some perspective to this availability concept when she said, "Instant availability without continuous presence is probably the best role a mother can play." There is a balance between being there for your children and smothering them with your presence. Children need Mom to be available but not hovering over their lives in such a way that it robs them of independence and their ability to eventually fly from the nest.
Availability also doesn't mean that Mom is so focused on the needs of her family that she cannot take care of her own physical and emotional needs. Mom may be the site manager, but even a site manager has to step away from the job occasionally and take some time off. Who takes care of Mom? Mom has to learn the art of self-care.


Breakfast trays require a 10 person minimum. All breakfast trays are served with plates and napkins. Pastries also include butters and jellies. If your party does not need paper or utensils ask for our no paper discount.


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Among Us Was The PlayStation Store's Most Downloaded Game In December 2021
By LesliePosted on January 11, 2022
PlayStation's top downloaded games for December 2021 have been revealed, and across North American and European regions, Among Us rose to the top on both PS5 and PS4 consoles. Among Us made its console debut in December, and at a $4 price-point, the popular social game was an easy purchase for fans and newcomers alike.
While players were trying to figure out just who the most suspicious person around them was, the rest of the top ten featured newer games such as Call of Duty: Vanguard, Madden NFL 22, and Battlefield 2042 in the US and Canadian charts, while the European lists had a similar spread of games in its top ten list.
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A number of older games also reached the top 10, as Spider-Man: Miles Morales and the remastered edition of Marvel's Spider-Man were some of the most-downloaded games of the year across the world, while Ubisoft's Assassin's Creed Valhalla also earned a spot on the US chart. Considering that the Nordic sandbox was drastically discounted last year and came with a free upgrade option for newer consoles, it's not too surprising to see it resurface on the charts.
In the VR department, Beat Saber was the most-downloaded PSVR game in the US, Canada, and Europe, while the rest of those lists were populated by Job Simulator, Swordsman VR, and Superhot VR. For those players looking for a free-to-play experience, Fortnite was firmly entrenched at the top, while the rest of the world delved into games such as Genshin Impact, Destiny 2, and Rocket League.
The full rankings for North America and Europe, as provided on the official PlayStation Blog post, are listed below.
PlayStation Top Monthly Downloads – December 2021
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Hemolysins or haemolysins are lipids and proteins that cause lysis of red blood cells by disrupting the cell membrane.  Although the lytic activity of some microbe-derived hemolysins on red blood cells may be of great importance for nutrient acquisition, many hemolysins produced by pathogens do not cause significant destruction of red blood cells during infection.  However, hemolysins are often capable of lysing red blood cells in vitro.

While most hemolysins are protein compounds, some are lipid biosurfactants.

Properties
Many bacteria produce hemolysins that can be detected in the laboratory.  It is now believed that many clinically relevant fungi also produce hemolysins.  Hemolysins can be identified by their ability to lyse red blood cells in vitro.

Not only are the erythrocytes affected by hemolysins, but there are also some effects among other blood cells, such as leucocytes (white blood cells). Escherichia coli hemolysin is potentially cytotoxic to monocytes, lymphocytes and macrophages, leading them to autolysis and death.

Visualization of hemolysis (UK: haemolysis) of red blood cells in agar plates facilitates the categorization of Streptococcus.

Mechanism
One way hemolysin lyses erythrocytes is by forming pores in phospholipid bilayers.  Other hemolysins lyse erythrocytes by hydrolyzing the phospholipids in the bilayer.

Pore formation

Many hemolysins are pore-forming toxins (PFT), which are able to cause the lysis of erythrocytes, leukocytes, and platelets by producing pores on the cytoplasmic membrane.

Hemolysin is normally secreted by the bacteria in a water-soluble way.
These monomers diffuse to the target cells and are attached to them by specific receivers. After this is done, they oligomerize, creating ring-shaped heptamer complexes.

Hemolysins can be secreted by many different kinds of bacteria such as Staphylococcus aureus, Escherichia coli or Vibrio parahemolyticus among other pathogens.
We can take a look at the bacterium Staphylococcus aureus as a specific example of pore-forming hemolysin production. Staphylococcus aureus is a pathogen that causes many infectious diseases such as pneumonia and sepsis. It produces a ring-shaped complex called a staphylococcal alpha-hemolysin pore. In nature, Staphylococcus aureus secretes alpha-hemolysin monomers that bind to the outer membrane of susceptible cells. Upon binding, the monomers oligomerize to form a water-filled transmembrane channel that facilitates uncontrolled permeation of water, ions, and small organic molecules. Rapid discharge of vital molecules such as ATP, dissipation of the membrane potential and ion gradients, and irreversible osmotic swelling leading to the cell wall rupture (lysis) can cause death of the host cell.

This pore consists of seven alpha-hemolysin subunits, which represent the major cytotoxic agent that is freed by this kind of bacterium. These subunits attach to the target cells in the manner described before, and extend the lipid bilayer, forming the pore structures. These pores in the cellular membrane will eventually end up causing cell death, since it allows the exchange of monovalent ions that would cause the DNA fragmentation.

Enzymatic
Some hemolysins damage the erythrocyte membrane by cleaving the phospholipids in the membrane.

Staphylococcus aureus hemolysins

α-hemolysin

Secreted by Staphylococcus aureus, this toxin binds with the outer membrane, with subsequent oligomerization of the toxin monomers to form water-filled channels. These are responsible for osmotic phenomena, cell depolarization and loss of vital molecules (v.gr. ATP), leading to cell death.

β-hemolysin
β-hemolysin (hlb; ) is a Phospholipase C toxin secreted by S. aureus. Upon investigating sheep erythrocytes, its toxic mechanism was discovered to be the hydrolysis of a specific membrane lipid, sphingomyelin, which accounts for 50% of the cell's membrane. This degradation was followed by a noticeable rise of phosphoryl-choline due to the release of organic phosphorus from sphingomyelin and ultimately caused cell lysis.

γ-Hemolysin
γ-Hemolysins are pore-forming toxins in the same family as α-Hemolysin. They are unique in that they come in two components, and hence are referred to as bi-component toxins (). Compared to beta-hemolysin, it has a higher affinity for phosphocholines with short saturated acyl chains, especially if they have a conical form, whereas cylindrical lipids (e.g., sphingomyelin) hinder its activity. The lytic process, most commonly seen in leucocytes, is caused by pore formation induced by an oligomerized octamer that organizes in a ring structure. Once the prepore is formed, a more stable one ensues, named β-barrel. In this final part, the octamer binds with phosphatidylcholine.

Structure
The structure of several hemolysins has been solved by X-ray crystallography in the soluble and pore-forming conformations. For example, α-hemolysin of Staphylococcus aureus forms a homo-heptameric β-barrel in biological membranes. The Vibrio cholerae cytolysin also forms a heptameric pore, however Staphylococcus aureus γ-hemolysin forms a pore that is octameric.

The heptamer of α-hemolysin from Staphylococcus aureus has a mushroom-like shape and measures up to 100 Å in diameter and 100 Å in height. A membrane-spanning, solvent-accessible channel runs along the sevenfold axis and ranges from 14 Å to 46 Å in diameter. On the exterior of the 14-strand antiparallel β barrel there is a hydrophobic belt approximately 30 Å in width that provides a surface complementary to the nonpolar portion of the lipid bilayer. The interfaces are composed of both salt-links and hydrogen bonds, as well as hydrophobic interactions, and these contacts provide a molecular stability for the heptamer in SDS solutions even up to 65 °C.

Role during infection
Hemolysins are thought to be responsible for many events in host cells. For example, iron may be a limiting factor in the growth of various pathogenic bacteria. Since free iron may generate damaging free radicals, free iron is typically maintained at low concentrations within the body. Red blood cells are rich in iron-containing heme. Lysis of these cells releases heme into the surroundings, allowing the bacteria to take up the free iron. But hemolysin is related to bacteria not only in this way but also in some others.

As mentioned before, hemolysin is a potential virulence factor produced by microorganisms, which can put a human's health at risk. Despite causing some severe pathologies, many cases of hemolysis do not suppose a health hazard. But the fact that hemolysins (produced by pathogenic microorganisms during infections) are combined with other virulence factors may threaten a human's life to a greater extent.

The main consequence of hemolysis is hemolytic anemia, condition that involves the destruction of erythrocytes and their later removal from the bloodstream, earlier than expected in a normal situation. As the bone marrow cannot make erythrocytes fast enough to meet the body's needs, oxygen does not arrive to body tissues properly. As a consequence, some symptoms may appear, such as fatigue, pain, arrhythmias, an enlarged heart or even heart failure, among others.

Depending on the type of hemolysin and the microorganism that produces it, manifestation of symptoms and diseases may differ from one case to the other:
 Alpha-hemolysin from uropathogenic E. coli produces extra-intestinal infections and can cause cystitis, pyelonephritis, and sepsis. Alpha-hemolysin from Staphylococcus aureus can cause severe diseases, such as pneumonia.
 Aerolysin from Aeromonas sobria infects the intestinal tract, but it might also cause sepsis and meningitis.
 Listeriolysin from Listeria monocytogenes (a facultative intracellular bacterium that thrives within host cells, mainly macrophages and monocytes) causes the degradation of phagosome membranes, but they are not a potential danger for the cell's plasmatic membrane.

Both aerolysin and alpha-hemolysin are synthesized by extracellular bacteria, which infect specific tissue surfaces.

Hemolysins have proved to be a damaging factor for vital organs, through the activity  of Staphylococcus aureus. S.aureus is a dangerous pathogen that may lead cells to necrotizing infections usually recognized by a massive inflammatory response leading to tissue damage or even tissue destruction. There is a clear example of this: the pneumonia produced by S.aureus. In this case, it has been proven that alpha-hemolysin takes part in inducing necrotic pulmonary injury by the use of the NLRP3 inflammasome, which is responsible for inflammatory processes and of pyroptosis. Pneumonia caused by S.aureus is a common disease in some areas, which is the reason for the many studies in the field of immunology aimed at developing new farmacs to cure easily or prevent this kind of pneumonia. At the moment, apiegnin and beta-cyclodextrin are thought to alleviate S.aureus pneumonia, whereas the antibodies of anti alpha-hemlysin are thought to give protection.

Further findings show that the main virulence factor of S. aureus, the pore-forming toxin α-hemolysin (Hla), is the secreted factor responsible for the activation of an alternative autophagic pathway. It has been demonstrated that this autophagic response is inhibited by artificially elevating the intracellular levels of cAMP.  This process is also mediated by the exchange factors RAPGEF3 and RAP2B.

Another interesting point is that pretreatment of leukocytes with doses of alpha-hemolysin at which nearly 80% of the cells survived decreased the ability of the cells to phagocytize bacteria and particles and to undergo chemotaxis. Premature activation of leukocytes and inhibition of phagocytosis and chemotaxis by alpha-hemolysin, if they occur in vivo, would greatly enhance the survival of an E. coli attack.

Some hemolysins, such as listeriolysin O, allow bacteria to evade the immune system by escaping from phagosomes. Hemolysins may also mediate bacterial escape from host cells.

Regulation of gene expression

The regulation of gene expression of hemolysins (such as streptolysin S) is a system repressed in the presence of iron. This ensures that hemolysin is produced only when needed. The regulation of the production of hemolysin in S.aureus(expression of hemolysin) is now possible due to in-vitro mutations that are related to serine/threonine kinase and phosphatase.

Treatment
As hemolysins are produced by pathogenic organisms, the main treatment is the intake of antibiotics specific to the pathogen that have caused the infection. Moreover, some hemolysins may be neutralized by the action of anti-hemolysin antibodies, preventing a longer and more dangerous effect of hemolysis within the body.

When blood cells are being destroyed too fast, extra folic acid and iron supplements may be given or, in case of emergencies, a blood transfusion. In rare cases, the spleen must be removed because it filters blood and removes dead or damaged cells from the bloodstream, worsening the lack of erythrocytes.

Applications

Medicine
Thermostable Direct Hemolysin (TDH; ) produced by Vibrio parahaemolyticus is now being studied in the field of oncology. It regulates cell proliferation in colon carcinoma cells. TDH induces Ca2+ influx from an extracellular environment accompanied by protein kinase C phosphorylation. Activated protein kinase C inhibits the tyrosine kinase activity of epidermal growth factor receptor (EGFR), the rational target of anti-colorectal cancer therapy.

See also
 Hemolysis (microbiology)
 Pore-forming toxins
 Staphylococcus aureus

References

External links

Bacterial toxins
Transmembrane proteins
Protein domains


Here are some quick facts about this report and what they tell us about the issues that the healthcare industry as a whole needs to address: 58% of incidents involved insiders—healthcare is the only industry in which internal actors are the biggest threat to an organization. Medical device hacking may create media hype but the assets most often affected in breaches are databases and paper documents. Ransomware is the top malware variety by a wide margin. 70% of incidents involving malicious code were ransomware infections. Basic security measures are still not being implemented. Lost and stolen laptops with unencrypted PHI continue to be the cause of breach notifications.


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Classically styled with a polished stainless steel exterior and a satin finished interior, the Calphalon Tri-Ply Stainless Steel 12-in. Stir-Fry Pan is designed with three layers to ensure even, consistent heating. A heavy-gauge aluminum core surrounded by stainless steel provides excellent heat conduction for browning and searing, while giving you enhanced control of the cooking process. Designed like a wok, these stainless steel pans are perfect for creating crisp, healthy vegetable or meat stir frys. Includes tempered glass cover.
Calphalon Tri-Ply Stainless Steel 12-in. Stir Fry with Cover is rated 4.1 out of 5 by 29.
Rated 1 out of 5 by mbkid88 from Horrible Lid Design its a wok,it works like other woks. the flat bottom may or may not be an advantage. Traditional woks do not have flat bottom. But the reason for the 1 Star rating is the glass lid with metal trim.... water and grease / fat that has splattered onto the glass lid will tend to flow and seep into the seams of the trim, no way to clean it out! and when heated up duing use, all that nasty grease and old liquids will flow back out and onto your food inside the wok... Just Horrible!!!! Defect in design for sure.
Rated 5 out of 5 by terry53 from My First Stir Fry Pan...WOW! I purchased this pan in December and used it the first time last week. The pan was easier to use then I expected, the food heated up quickly and uniformly. This stir fry pan was the first pan of this type of I have owned...would highly recommend it.
Rated 3 out of 5 by Seth from Some issues It's okay, but there are some problems. As others have mentioned, food tends to stick when browning / searing. My bigger complaint is that water has gotten between the glass and rim of the lid and when heated is forced out and drips into food, which is pretty gross.
Rated 1 out of 5 by Andrea from Not for stir fry I have used this wok 3 times now. Each time I coated the interior with olive oil to prevent sticking, used a medium heat, and every single time the food stuck to the interior and then began browning the surface and even smoking a little. The only thing that seems to be helpful at all is adding water/liquid to dislodge the food as soon as it starts sticking. So if you're cooking things in it that have a lot of sauce, such as curries, you wouldn't have a problem. But if you want to do a classic East Asian stir fry, a fried rice, or any stir-fried noodle dishes (as the name of the product and the description indicate you should be able to do), your ingredients will stick and it will be very difficult to clean out your wok if in fact you can even get it clean at all. This is a wok for sauces, NOT for stir fry. I am incredibly disappointed because I have loved my stainless steal soup pot, but upon reflection I have the same issue when I saute garlic or onions to start a soup. If you want to stir fry, stainless steal is not the surface. It will stick.


text:
__author__ = 'olga.ostapenko'

from model.contact import Contact

def test_modify_first_contact(app):
    app.session.login(username="admin", password="secret")
    if app.contact.count() == 0:
        app.contact.create(Contact(First_Name="test", Middle_Name="test", Last_Name="test", Company_Name="Test Company",
                                   Address="Test Address", Home_Phone="12345", Mobile_Phone="12345", Work_Phone="12345",
                                   Email="test@test.com", Homepage="www.test.com", Birthday="1984", Anniversary="2017",
                                   Secondary_Address="Test Address"))

    app.contact.modify_first_contact(
        Contact(First_Name="Updated First_Name", Middle_Name="Updated Middle_Name", Last_Name="Updated Last_Name",
                Company_Name="Updated Company_Name", Address="Updated Address", Home_Phone="Updated Home_Phone",
                Mobile_Phone="Updated Mobile_Phone", Work_Phone="Updated Work_Phone", Email="Updated Email",
                Homepage="Updated Homepage", Birthday="1984", Anniversary="2017",
                Secondary_Address="Updated Secondary_Address"))
    app.session.logout()


// be relocated in memory whenever the table expands itself.
was evicted from that spot (if one exists).
// WARNING! if this function causes a segfault, check the hash code function!
// if we've gotten here then we almost assuredly hit an infinite rehashing loop; expand the tables and try again.


The Hawaii Department of Human Services in Honolulu needs a replacement or upgrade to its automated welfare system. The system works with public assistance programs, such as Aid to Families with Dependent Children, food stamps, Medi-Cal, foster care, refugee assistance and county medical service programs. The project is worth $1 million, and a request for proposals is expected in April.


Chocoholics raised over £640 at our Big Chocolate Tea Party!
It's no secret we love a sweet treat here at Woman's Own, so we knew we had to do something big for our own Big Chocolate Tea Party! We partnered up with The Sick Chidren's Trust for the second year running for a making and baking extravaganza – and our chocoholics definitely delivered!
Bake Off's finest, Cat Dresser and master chocolatier, Paul A Young, were at hand to taste over 40 baking creations, crowning a winner from each category and then an overall winner. Each winner took home some amazing Kenwood treats to bake up some more tasty treats at home for their lucky families.
After the expert judging was finished the rest of us got to tuck into all the delicious bakes when they were sold off, and more chocolate treats were up for grabs in our charity tombola. In total, a whopping £640 was raised for The Sick Children's Trust.
A fun day was made that bit better by the news that we had beaten last year's fund raising total, which meant The Sick Children's Trust was able to help 30 families like The Normans.
TOWIE stars joined in the fun and hosted their own Big Chocolate Tea party too.
Want to help Woman's Own and The Sick Children's Trust raise even more this year? Why not hold your own Big Chocolate Tea party? Click here to find out how you can get involved!


A SHEEP pain relief product developed in Australia by Emergence client, Animal Ethics, has been approved for clinical trials for human use in the United Kingdom. Click here to read the full story!
The UK's Medicines and Healthcare products Regulatory Agency (MHRA) has approved its application for a Phase IIa clinical trial of Tri-Solfen® (for human use the product will be branded as Medi-Solfen®) for the treatment of pain during the surgical debridement of venous leg ulcers.
Medi-Solfen® is an innovative medicine designed to provide rapid onset and both short and prolonged analgesia effects for up to 24 hours. The topical gel contains two local anaesthetic agents and an antiseptic, and other active ingredients, designed to minimise bleeding and potentially protect against infection as well as promote healing.
The Phase IIa clinical trial will assess the safety and efficacy profile of Medi-Solfen® in providing anaesthesia when applied topically to venous leg ulcers, prior to and post-surgical debridement.
The open, randomised, parallel group-controlled study will be conducted in 90 patients in three successive stages, which aim to study the time taken to achieve surface anaesthesia, degree of post-operative pain relief and patient's assessment of overall quality as an anaesthetic during this procedure.
Secondary objectives include the duration and quality of post-operative pain relief following a single-dose, levels of anaesthesia achieved, and influence on the early healing trajectory of the leg ulcer.


Piotr Ikonowicz is a special adviser to the Palikot movement, which was the third political force at the Polish legislative elections of October 2011 and which aims at reshuffling the liberal, social and green agenda of the Polish left.
With one of the highest growth rates in the European Union, the Polish economy seems to escape the crisis. But there is another side of the coin. The Polish are working more and more but earning less. This is the result of a practical obligation to systematically work overtime during weekends and the impossibility of taking annual leave. But what is the social impact of this inequality?


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text:
20 years ago, it finally was Mark O'Meara's turn for Masters glory
Published on Monday, April 2, 2018
The 20th anniversary -- Mark O'Meara wins first Masters
It was finally Mark O'Meara's turn.
The 41-year old was one of the golfers labeled as the best to never have won a major. That talk ended in 1998.
O'Meara sunk a 20-foot birdie putt on No. 18 to close the tournament with 5-under par 67 Sunday round. He finished the tournament at 9-under par. The closing putt was enough to give O'Meara a one-stroke victory over David Duval and Fred Couples.
O'Meara birdied three of the final four holes to pull off the win, recording the scores at Nos. 15, 17 and 18.
O'Meara would win the British Open later that year, his only other major title.
"To win a major championship, especially the Masters, is a dream come true for me," O'Meara said at the time. "I feel very honored and very proud."
Tiger Woods, who won his first Masters the previous year, and O'Meara had developed a friendship and became Florida neighbors. So when Woods slipped the green jacket on O'Meara, he whispered, "You deserve this."
O'Meara started the final round two strokes behind the leader Couples. O'Meara caught Couples early and the two stayed close to each other -- until Duval made a charge. He took a two-stroke lead after No. 13 at 8-under par with an eagle. Couples double bogeyed the same hole to join O'Meara at 6-under par. After 15 holes, it was Duval at 9-under, Couples at 8-under and O'Meara at 7-under. Duval bogeyed No. 16 and finished with two pars. Couples finished with three pars. But O'Meara won with birdies on the final two holes, including the lengthy putt on his final stroke.
The tournament will also be noted by yet another incredible late charge by Jack Nicklaus. Now 58, and 12 years after he shocked the world by winning the 1986 Masters, Nicklaus tied for sixth with a score of 5-under par. The finish, the oldest to finish in the top 10, came with a 4-under par 68 on Sunday.
Long-time Atlanta Journal-Constitution columnist Furman Bisher wrote this on the Nicklaus dramatics: "Yes, Mark O'Meara won the tournament and the precious Green Jacket that goes with it, but Jack Nicklaus won this Masters in a way that only Jack Nicklaus could. He won the hearts. The sound of his name resounded among the tall pine forests of Augusta National, and cries of adulation and exhortation. It was as if he were 46 again, or 36, and on the charge on a Sunday afternoon a splash in sunshine.
"Instead, he was an old warrior of 58 for whom walking is painful and whose hips ache. He who was serenaded by the membership of Augusta National Golf Club in a ceremony usually reserved for retirees, observed his 40th Masters. He has won it six times, but that wasn't enough. He wanted another."
The 62-year-old Gary Player became the oldest to make the cut at the Masters.
O'Meara won 34 times in his career and was inducted into the Golf Hall of Fame in 2015.
This article is written by Chris Vivlamore from The Atlanta Journal-Constitution and was legally licensed via the Tribune Content Agency through the NewsCred publisher network. Please direct all licensing questions to legal@newscred.com.


13 Days of Halloween – Day 12 | Trick or Treat!
Hey There, This is my last card for the Halloween season this year. I will have one more video to finish up the 13th day but I need to wait until after I'm sure the recipient has it as I don't want to ruin the surprise. For this card, I combined two MFT stamp sets… Continue reading 13 Days of Halloween – Day 12 | Trick or Treat!


text:
Odorrana bolavensis is a species of frog in the family Ranidae. It is endemic to the Bolaven Plateau, Laos. Its natural habitats are wet evergreen forest. It can be found at night on rocks and vegetation along rocky streams, occasionally on leaf-litter or tree branches away from streams.

References

bolavensis
Amphibians described in 2005
Frogs of Asia
Amphibians of Laos
Endemic fauna of Laos
Taxonomy articles created by Polbot


So after living with ET for the past 10years and never doing any research into what it was or how many other people are affected by it, I thought it was time to finally have a look!
Just to give you some insight into my background I'm a 23year old female living in the UK and was diagnosed with ET at 13years old! From what I've been told by previous doctors I am one of the youngest people to have been diagnosed with ET.
Over the years I have been on most of the medication available to ET sufferers from Hydroxeurea (tablet form) to Anegralide (tablet form) and finally peg interferon (injection) without realising I have suffered most of the side effects of the treatments but have never voiced them to a doctor because somewhat unwittingly having had the disorder for so long and from such a young age I never realised that the symptoms I had where down to me having ET and taking medication for it.
Symptoms range from – hair loss, burning sensation in hands and arms, fatigue and general tiredness (all the time), shortness of breath, pins and needles, needing the toilet all the time and finally severe anxiety!
Today is the first day that I have realised that all these symptoms which I just consider to be 'normal' are actually down to me taking medication for ET. Even so I want to stress that I feel that even with these symptoms I have lived a completely normal lifestyle and most of the time even forget I have ET.
It's taken me 10years to realise that there are support groups out there for people like myself and hopefully now I can get some of the questions answered that have been preying on my mind all these years. And in return I hope that I can help and support people like me that have had to deal with ET from a young age.
Hi Thanks for getting in touch, My anxiety has got worse in the last 2 years I don't know if it's been down to increasing my medication or maybe it's just because now I'm older I am more aware of things around me and have responsibilities such as a mortgage etc... to worry about. I don't know about you but my anxiety results in me getting so anxious about seemingly nothing other than just life in general that I cry quite a lot completely un- announced. Does anyone else's anxiety result in these symptoms?
We're you put on medication straight away when you were diagnosed? My daughter isnt on any at the moment but when the time comes i think her haem is talking about Anegralide.
Where are you based? I love to hear from young people as i think my daughter is probably one of the youngest at the moment.
Hi thanks for getting in touch. I think my best advice to you would be to not treat your daughter any differently, my parents never treated me any differently and I have lived a perfectly normal life I don't do anything any different to if I hadn't of had ET. I work 50 hours a week and have a very active social life in the evenings after work and at weekends I spend most of my time either shopping, horse riding, rock climbing, skiing and going out drinking socially usually on friday nights. I do get tired but always put it down to how busy I am all the time.
When I was first diagnosed I was rushed to the children's cancer ward and immediately put on hydroxeurea and for the first week I was on it was violently sick every time I took it. I don't know if this was more down to stress and anxiety of me being 13 and thinking I was going to lose all my hair like the other patients on the ward. But after a week the sickness subsided and ever since then on every different medication I take I get flu like symptoms and an achy feeling but I just take paracetamol and its gone in a couple of hours. I always take my medication at night so I think I must sleep through most of the symptoms.
I'd be more than happy to talk to you or anyone else in more detail if you want to find out a bit more. I'm planning on attending the talk in Cardiff in Oct to hopefully meet some other people with ET.
To be honest with you I have absolutely no idea what my first doctor was or even his name. When I was 16 I was transferred to an adult heamotolgy outpatients ward and my doctor is a called Dr Guy Lucas, I don't know whether he is a MPD specialist I never thought to ask the question before. That might sound a bit naive but I've always just gone along with what the doctors said a lot of the time dr Lucas isn't around and I just end up seeing a stand in DR who never knows what to do with me, I normally end up advising them to either increase my meds or keep them the same depending on my platelet count.
Hi I was diagnosed with ET at age 35 (in 2004) - platelet count was 2000. Since then been taking Hydroxeurea x 5 daily. This was 6 in the early stages but 5 seems to give some stability. Its very interesting to read that some people suffer from anxiety as this is the case with me and now visiting psychotherapist and taking anti-depressants for 3 years. I have found my anxiety is getting worse but never ever thought it could possibly have something to do with the medication. I have since moved back to Holland where I was originally from and will need to have another bone puncture soon as my puncture results when I was diagnosed in 2004 were unsatisfactory. I only found this out recently as my new haematologist needed the results. I was seeing a great Haemotologist in Carlisle who is now semi-retired. I am going to find a MPD specialist in Utrecht hospital. Thank you for sharing your stories its good to know there is a support forum for all of us.
Hi Jennie, really pleased to see that you have found the group but sad to hear that you are having symptoms of anxiety. The only advice I can think to add, is to see if you can find an MPD clinic somewhere. I live in London and therefore have been lucky enough to get to Guys Hospital. However, I know others on here have MPD clinics they go to around the country. You can always ask for a referral to a specialist clinic to run alongside your haematology clinic.
If so I recommend Guys in London.
Also, I am wondering what your platelet counts were when you were 13, they must have been pretty high, very frightening for you. Not wanting to sound too psycho babbly but maybe you are just beginning to process all of that now you are an adult?? Just a hypothesis that may be part of your anxiety issues.
I have ET, btw, but only need aspirin, which helps me enormously. Good luck and take care.
just seen your post and wondered if you had spoken to your haematologist about the side effects of interferon - I am taking that for et, after hydroxy was no longer effective and it has been really good at controlling my counts so that my platelets are now around the 400 mark. However earlier this year I suffered from lots of side effects, bordering on depression and under active thyroid - hair loss/fatique/dis-interest in my family/ I could hardly think straight and each day was a major challenge. Fortunately I realised that the meds had been affecting me and discussed reducing the dose to see what happened and I felt quite a lot better after 2-3 weeks AND my counts stayed stable/low - have since reduced meds again and have a consult next week to review. I feel so much better, clear headed, not anxious or tired so if you haven't looked at this with the haematologist do broach it - I have another friend who had to be taken off interferon due to depression.
If your haem is not willing to discuss this it may be worth asking for a referral to an MPD specialist unit as you are young and you do want a quality life as well as good control of the blood counts and unfortunately some consultants forget this.
Take care I'd recommend that you try to become an expert and your own project manager of the condition as it's quite rare and research and trials are moving head of the general haematologists knowledge.
Thank you for your excellent message. Bless you , so young to receive the diagnosis, a special lady!
I was diagnosed last year but at the old age of 60!! More common.
I so hope you keep well. There does seem to be a variety of symptoms linked to the condition but I think you are right, I have looked upon it as a new social group and we hope to help with research.
My hospital team are brilliant and very informative.
Please feelw elcome to keep in contact.