text:
The Rapidian
Place Matters
Teen violence prevention program launches summer campaign
Family Futures
metro nonprofits
Goal to get RAVE back in 50 classrooms this school year aimed at stopping the cycle of violence
RAVE empowers Grand Rapids teens to live violence free with healthy relationships /David Chandler
Underwriting support from:
Save RAVE Campaign
Physical aggression occurs in one in three teen dating relationships. This violence is preventable. Resources Against Violent Encounters (RAVE) stops the cycle of violence by empowering teens with the skills and confidence to avoid or escape abusive relationships. Join Family Futures this summer in raising funds to serve 50 classrooms in the 2013-14 school year. RSVP for the campaign kickoff event Thursday June 13 at the Women's City Club.
It started because of a need. The need to break the cycle of violence, spinning faster and faster throughout our community.
And now it's a program in need – a need for funding to stay in our schools where it can make an impact.
Founded in 1994 a decade after the rape and murder of Mary Murch, Resources Against Violent Encounters (RAVE) is a program that empowers teens to have healthy relationships – while recognizing an unhealthy relationships and how to get out of them. The program, once a stand-alone organization and now run by Family Futures, does three to nine sessions in middle and high school classrooms with engaging and interactive curriculum to empower our next generation to live violence-free.
Honoring Mary: RAVE begins
To her family, Mary Murch's death was at first a random, horrific act of violence. The 17-year-old who took her life was a complete stranger – knocking on the door of her apartment one night, asking to use her phone.
But then Lana Murch, Mary's sister-in-law, dug deeper.
"A few years after it all, I reviewed his records from the court," Murch said. "I found out he was horribly abused and neglected as a child. That's when I realized this is a cycle of violence."
In those years, additional violence continued to open Murch's eyes – her mother's friend killed, a neighbor's daughter raped and abducted. Murch said she felt called to take action, but wanted to do something that would go to the root of it all – something that could prevent violence from ever happening.
"This was something personally I could do that would honor the memory of Mary, to make her death have meaning and to make a difference in someone else's life," Murch said. "What happens when children are abused? They grow up and do things like this. They are so broken. It doesn't take away from the fact that they did it and are responsible and need to be punished, but on the other level it's just this cycle."
Murch and her friend Constance Grzanka co-founded RAVE. The two were focused on proactive and systemic change through prevention education, awareness and advocacy. The program would go in middle and high school classrooms with a curriculum designed specially for teens to promote healthy relationships and end abusive ones.
"There was nothing like that at the time," Murch said.
RAVE grows, joins Family Futures
Serving a large portion of Grand Rapids Public Schools and others, RAVE grew steadily. With an increasing demand for service, the program merged with Family Futures in 1999 (at the time, Family Futures was called the Child and Family Resource Council). Most of Family Futures' programming is geared toward parents with young children. But with a goal of preventing abuse and neglect, and knowing the abuse that Mary's killer went through as a child, Murch saw it as a perfect fit.
"It's all tied together," she said. "Family Futures is committed to prevention and believes prevention is the most effective way to protect children, youth and families from abuse and neglect."
Now on the verge of 20 years, RAVE is struggling with sustainable funding. Grants and public dollars are not as readily available as they once were. This past winter, Family Futures had to put the program on hiatus with no funding remaining for serving additional classrooms.
"This program is desperately needed – without it there is no program in our schools encouraging healthy relationships," said Lucy Joswick, the Family Futures Community Development Director and a former RAVE participant herself. "Violence is preventable. That's why we must keep RAVE going."
Save RAVE: A campaign to sustain
This summer, Family Futures aims to do just that with the Save RAVE campaign. The goal is to raise $12,500 from donors within the community. With the average cost of $250 to serve a classroom, the campaign would allow 50 classrooms in the 2013-14 school year to receive RAVE programming. Individuals can sign up to adopt a classroom that they'll raise funds for, and when they do, they'll become a part of the new Violence Free Society launching as part of the campaign.
The campaign begins this Thursday, June 13 with a kickoff event at the Women's City Club. The event will let people experience the program firsthand, as they stroll through a variety of 10-minute mini-sessions run by RAVE facilitators, covering topics like media influence and power and control exercises.
"We hope when people see the program up close and feel what it's like to be a teen experiencing these things, they'll be inspired to be a part of this group that supports RAVE," Joswick said.
The campaign will wrap up with a celebration event in August – just in time to prep for a new school year of bringing RAVE to classrooms throughout Grand Rapids.
"I believe that prevention is one of the most effective ways to promote healthy and safe relationships and to protect children, youth and families from abuse and violence," Murch said. "This work is important to make a difference – for Mary and all individuals who have been victims of abuse or violence."
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If each of our readers and content creators who values this community platform help support its creation and maintenance, The Rapidian can continue to educate and facilitate a conversation around issues for years to come.
Please support The Rapidian and make a contribution today.
familiy futures
teen relationships
JA of the Michigan Great Lakes Hosts Inaugural Pitch Competition for High School Students to Compete for Over $3,000 in Scholarship Awards to Grand Rapids Community College
Junior Achievement of Michigan Great Lakes
Getting the support he needs at Veterans Upward Bound
Grand Valley State University Veterans Upward Bound
At Camp Blodgett, the world is a classroom
Heart of West Michigan United Way
How Veterans Upward Bound is helping veterans stay focused on their goals
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MOTU VIGET
Place Matters.


text:
package org.jetbrains.plugins.scala.lang.typeInference
package generated

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  //This class was generated by build script, please don't change this
  override def folderPath: String = super.folderPath + "expected/param/"

  def testApplyDecision() {doTest()}

  def testComlexCase() {doTest()}

  def testComplexCombination() {doTest()}

  def testCurrings() {doTest()}

  def testCurringsUnderCall() {doTest()}

  def testDeepNamingParam() {doTest()}

  def testDeepParam() {doTest()}

  def testGenericMethod() {doTest()}

  def testNamingParam() {doTest()}

  def testParam() {doTest()}

  def testParamForSeq() {doTest()}

  def testSCL2880() {doTest()}

  def testTuplingCase() {doTest()}
}

redpajama_set_name: RedPajamaGithub


Perfect Posing for Pretty Pictures!
If you have trouble posing people, then you need to get this instructional slide program. It's based on high school seniors but is applicable to anyone (humans only).
Over 600 images with man before and after examples to show what works and what doesn't.
This will help you create poses that sell.
I will email you a link to download the program. Because of it's size, I divided it into two parts.


text:
← Matthew Pavlich
Mark Baguley →
Jake Carlisle
Team Website: www.essendonfc.com.au
Twitter: @jcarlisle22
Facebook: Jake Carlisle Facebook
Wikipedia: Jake Carlisle Wikipedia
Jake Carlisle currently plays for the Essendon FC and was born on the 1st October 1991 ( 76 other players in the league were born in 1991, the most common year of birth is 1992 giving an average age of 22).
Jake currently stands at 200 centimeters tall ( which is taller than the AFL average player height of 188 centimeters) and weighs 98kg's ( which is heavier than the AFL average player weight of 87.4 kg's ). Carlisle had his AFL debut in Round 20 of 2010 (61 other players also had their debut in 2010).
Jake played 18 games in 2012 ( average number of games played by players was 12.97 and 26 other players also played 18 games) and has now played 28 games in his entire career, the average being 62.3 games and the same as 5 other players in the league.
Jake scored 2 goals in 2012 which is below the average in 2012 of 8.15 goals and the same as 50 other players.
In his entire career Jake has scored 7 goals the same as 9 other players and below the average of 38.54 goals.
This entry was posted in AFL and tagged AFL, Essendon FC, Jake Carlisle. Bookmark the permalink.

redpajama_set_name: RedPajamaCommonCrawl


Date and Time: The training will commence in July and exact date of the program will be announced/intimated closer to the event. Training session will be for 6 hours.
Venue: Will be communicated later.
Posted in Mumbai and tagged Environment.


RONAN — Stewart Dale "Stew" Schiele passed away on March 28, 2019 at age 71. He was born on Jan. 5, 1948, in Ronan, at the family home, to Martin and Elsie Schiele, the 11th of 12 children.
Stew graduated from Ronan High School and joined the Navy in 1968. He graduated from welding school as a nuclear components welder and during the Vietnam War Stew served two tours to the Tonkin Gulf, one on the USS Worden and one aboard the USS Bainbridge. After his service Stew and Faye returned to Ronan to raise their boys in the valley that he called home.
Stew held many jobs in the area including at the Stove Shop, masonry work with his brothers and driving truck. He enjoyed the outdoors, hunting, camping and fishing with his family and friends.
Stew is survived by his wife of 48 years, Faye; their sons, Robin (Heather) Schiele and Ron (Annette) Schiele; his grandchildren, Marcus, Tashea, Gavin, Gatlin and Anna; as well as his great-grandchildren, Tristan, Brantley, and Dacre; his sisters, Delores David and Sandra Noble; and his brothers, Raymond, Ronald and Larry.
Stew was preceded in death by his parents, Martin and Elsie; his sisters, Eileen Frazer and Donna Toelke; and his brothers, Marvin, Norman, Harold and Dennis.
A memorial service followed by military honors will be held on Saturday, April 6, 2019, at 1 p.m. at Mt. Calvary Lutheran Church, 1608 Second Street W, in Polson, with Rev. Kyle Whaley officiating and a celebration of Stew's life will be held at the North Crow Club House in Ronan after the service.


Chief Richard J. Ficco, Sr.
On January 12, 2019, The Richland Township Police Department arrested Jesse Loux, 30, of Richland Township, for Retail Theft, Resisting Arrest, Possession of an Instrument of Crime, Possession of Controlled Substance and Disorderly Conduct. The incident took place at Target, 610 North West End Blvd. Custody of Loux was transferred to the PA State Police, who had a warrant for Loux. Loux was transported to Montgomery County Correctional Facility.


text:
Macgowan, Kenneth, 1888-1963
Detailed View Similarity Assertions 1 Revision History Sources
His "The living stage" was published in 1955.
From the description of Letter, 1951 Sep. 18, Los Angeles, to Maurice Browne, London. (University of Michigan). WorldCat record id: 34365417
Macgowan was born in Winthrop, MA, Nov. 30, 1888; graduated Harvard, 1911; married Edna Behre, 1913; drama critic for Philadelphia evening ledger, the New York globe, Vogue, Theatre arts magazine, and Shadowland; publicity director for Goldwyn Pictures Corp., 1918-19; formed an association with Eugene O'Neill and Robert Edmond Jones at the Provincetown Playhouse; producer and director with the Actor's Theater, 1927-29; worked at RKO Studios (early 1930s-35), 20th Century Fox (1935-41), and Paramount Studios (1944-46); among his many film credits is La Cucaracha, the first production in modern Technicolor; instructor and first dept. chair at the UCLA Theater Arts Dept. (1946-58); studied both anthropology and archaeology; publications include The theater of tomorrow (1921), Footlights across America (1929), Early man in the new world (1950), Behind the screen : the history and technique of the motion picture (1965); he died of cancer on August 27, 1963.
From the description of Papers, 1915-1970. (University of California, Los Angeles). WorldCat record id: 38942505
Kenneth MacGowan collected African and Pre-Columbian art. He was a client of the Weyhe Gallery.
From the description of Correspondence with Carl Zigrosser, 1938-1939, n.d. (University of Pennsylvania Library). WorldCat record id: 155902096
Macgowan was born in Winthrop, Massachusetts, November 30, 1888; graduated Harvard, 1911; married Edna Behre, 1913; drama critic for Philadelphia evening ledger, the New York globe, Vogue, Theatre arts magazine, and Shadowland ; publicity director for Goldwyn Pictures Corporation, 1918-19; formed an association with Eugene O'Neill and Robert Edmond Jones at the Provincetown Playhouse; producer and director with the Actor's Theater, 1927-29; worked at RKO Studios (early 1930s-35), 20th Century Fox (1935-41), and Paramount Studios (1944-46); among his many film credits is La Cucaracha, the first production in modern Technicolor; instructor and first department chair at the UCLA Theater Arts Department (1946-58); studied both anthropology and archaeology; publications include The theater of tomorrow (1921), Footlights across America (1929), Early man in the new world (1950), Behind the screen: the history and technique of the motion picture (1965); he died of cancer on August 27, 1963.
From the guide to the Kenneth Macgowan Papers, 1915-1970, (University of California, Los Angeles. Library. Department of Special Collections.)
referencedIn Harvard University Archives Photograph Collection: Portraits, ca. 1852-ca. 2004 Harvard University Archives.
referencedIn Greenwich Village Theatre. Records of the Greenwich Village Theatre, 1925-1926 (inclusive). Harvard University, Houghton Library
creatorOf Macgowan, Kenneth, 1888-1963. Papers, 1915-1970. University of California, Los Angeles
referencedIn Eugene O'Neill papers, 1872-1970, 1930-1959 Beinecke Rare Book and Manuscript Library
referencedIn Welles mss., 1930-1950, (Bulk 1936-1947) Lilly Library (Indiana University, Bloomington)
creatorOf Agee, James, 1909-1955. James Agee Collection, 1928-1969. Harry Ransom Humanities Research Center
referencedIn O'Neill, Eugene, 1888-1953. Papers of Eugene O'Neill [manuscript], 1915-1940. University of Virginia. Library
referencedIn John Mason Brown papers, 1922-1967. Houghton Library.
referencedIn O'Neill, Eugene, 1888-1953. Eugene O'Neill collection, 1912-1993. Yale University, Beinecke Rare Book and Manuscript Library
creatorOf Macgowan, Kenneth, 1888-1963. Letter, 1951 Sep. 18, Los Angeles, to Maurice Browne, London. University of Michigan
creatorOf Twentieth Century-Fox Film Corporation. Correspondence with Margaret Naumburg, 1937. University of Pennsylvania Libraries, Van Pelt Library
creatorOf Adamic, Louis, 1899-1951,. Letters to Alfred Kreymborg [manuscript], 1921-1956. University of Virginia. Library
creatorOf Macgowan, Kenneth, 1888-1963. Correspondence with Carl Zigrosser, 1938-1939, n.d. University of Pennsylvania Libraries, Van Pelt Library
referencedIn Century Company records, 1870-1924 New York Public Library. Manuscripts and Archives Division
referencedIn Ellen Bartlett Ballow letters from various correspondents, 1926-1937. Harvard Theatre Collection, Houghton Library, Harvard College Library, Harvard University.
referencedIn Steele, Wilbur Daniel, 1886-1970. Daniel Wilbur Steele papers, 1907-1970. Stanford University. Department of Special Collections and University Archives
creatorOf Kenneth Macgowan Papers, 1915-1970 University of California, Los Angeles. Library. Department of Special Collections.
referencedIn O'Neill, Eugene, 1888-1953. Eugene O'Neill papers, 1872-1970 (bulk 1930-1959) Yale University, Beinecke Rare Book and Manuscript Library
referencedIn Stella Hanau Papers MS 73., 1904-1971 Sophia Smith Collection
referencedIn Friedman, Philip Allan. Correspondence to Philip Allan Friedman, 1952-1953. Yale University, Beinecke Rare Book and Manuscript Library
referencedIn Jones, Robert Edmond, 1887-1954. Drawing of The cherry orchard, [1922]. New York Public Library System, NYPL
referencedIn J. B. Matthews Papers, 1862-1986 and undated David M. Rubenstein Rare Book & Manuscript Library
referencedIn Hanau, Stella, 1890-1972. Papers, 1904-1971. Smith College, Neilson Library
creatorOf Browne, Maurice, 1881-1955. Ellen Van Volkenburg-Maurice Browne general correspondence, 1911- University of Michigan
creatorOf Ballou, Ellen Bartlett, 1905-. Letters : from various correspondents, 1926-1927. Harvard University, Houghton Library
creatorOf Macgowan, Kenneth, 1888-1963. Letter, 1951 Sep. 3, Los Angeles, to [Maurice Browne, London?] University of Michigan
referencedIn James Agee Collection TXRC98-A10., 1928-1969 Harry Ransom Humanities Research Center
creatorOf Boys, Richard Charles, 1912-. Correspondence, 1949-1954. University of Michigan
referencedIn Chapman, Robert Harris. Papers of Robert H. Chapman, 1963-1974 (inclusive). Harvard University, Archives
referencedIn Papers, 1920-1995. Houghton Library.
referencedIn George Pierce Baker papers, 1878-1958 Yale University. Department of Manuscripts and Archives
referencedIn O'Neill, Eugene, 1888-1953. Eugene O'Neill papers, 1872-1970 (bulk 1930-1959). Yale University, Beinecke Rare Book and Manuscript Library
creatorOf Macgowan, Kenneth, 1888-1963. Letter, 1953 Sep. 30, London, to Maurice [Browne, London?] University of Michigan
referencedIn Theatre Arts Monthly, collection of portraits, ca., ca., 1924-1939 (bulk), 1916-1964 (inclusive). Harvard Theatre Collection, Houghton Library, Harvard College Library, Harvard University.
creatorOf Macgowan, Kenneth, 1888-1963. Correspondence file, 1927-1930, from Boni & Liveright and Horace Liveright, Inc. University of Pennsylvania Libraries, Van Pelt Library
referencedIn Baker, George Pierce, 1866-1935. George Pierce Baker papers, 1878-1958 (inclusive). Yale University Library
creatorOf Macgowan, Kenneth, 1888-1963. Letter, 1951 Aug. 11, Los Angeles, to Maurice [Browne, n.p.]. University of Michigan
creatorOf Reber, J. Howard. Letter to Horace Howard Furness, Jr., 1929. University of Pennsylvania Libraries, Van Pelt Library
associatedWith Agee, James, 1909-1955 person
associatedWith Baker, George Pierce, 1866-1935. person
associatedWith Ballou, Ellen Bartlett, 1905- person
associatedWith Boys, Richard Charles, 1912- person
associatedWith Browne, Maurice, 1881-1955. person
correspondedWith Brown, John Mason, 1900-1969 person
correspondedWith Century Company corporateBody
associatedWith Chapman, Robert Harris. person
correspondedWith Dellenbaugh, Frederick Samuel, 1853-1935 person
associatedWith Friedman, Philip Allan. person
associatedWith Greenwich Village Theatre. corporateBody
associatedWith Hanau, Stella, 1890-1972 person
associatedWith Jones, Robert Edmond, 1887-1954. person
associatedWith Levin, Harry, 1912-1994 person
associatedWith Matthews, J. B. (Joseph Brown), 1894-1966 person
associatedWith O'Neill, Eugene, 1888-1953. person
associatedWith Reber, J. Howard. person
associatedWith Steele, Wilbur Daniel, 1886-1970. person
associatedWith Twentieth Century-Fox Film Corporation. corporateBody
associatedWith University of California, Los Angeles corporateBody
associatedWith University of California, Los Angeles. Dept. of Theater Arts corporateBody
associatedWith Welles, Orson, 1915-1985 person
Theatrical producers and directors--Archival resources
Motion picture producers and directors--Archival resources
Loyalty security program, 1947-
Theater critics--Archival resources
Birth 1888-11-30
Languages Used:
Virtual International Authority File WorldCat Identities LC Name Authority File Wikipedia
Permalink: http://n2t.net/ark:/99166/w6tb1pmf
Ark ID: w6tb1pmf
Mac Gowan Kenneth 1888-1963
Macgowan, Kenneth
Macgowan, Kenneth, 1888-
Mc Gowan Kenneth 1888-1963
McGowan, Kenneth 1888-1963
マックゴーワン, ケニス


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This year, 21 schools competed in the Diplomas Now Attendance Challenge. With a very tight race down to the final minutes of the Challenge, Miami Edison Middle School held out and won the Attendance Challenge with a total of 447 points! Finishing strong with a 2.89% increase in their attendance, Miami Edison fought for every point. Congratulations to Miami Edison Middle School who were visited by Flo Rida and Ace Hood.


text:
Shortening of telomere length by metabolic factors in diabetes: protective effects of fenofibrate.
People with diabetes mellitus have shorter telomeres compared with non-diabetic subjects. The aim of this study was to investigate an in-vitro model of telomere shortening under diabetes metabolic conditions. The mechanisms of the accelerated telomere length attrition and the potential telomere protective action of fenofibrate with related cellular mechanisms were also examined. Human dermal fibroblasts were passaged and cultured in normal (5.5 mM) or high (25 mM) D-glucose, across 7 days with hydrogen peroxide (H2O2), glucosamine (GA), or glycated albumin (AGEs-BSA). Relative telomere length (RTL) was determined by qPCR. The expression of shelterin complex members which regulate telomere stability were measured by qRT-PCR and Western immunoblot. Culture in high glucose decreased RTL compared with normal glucose: H2O2 and GA lowered the RTL after 7 days (each P < 0.05 vs untreated control), whereas AGEs-BSA had no effect compared with control-BSA. At day 7 the mRNA levels of most shelterin complex members, were induced by H2O2 and to a lesser extent by GA. Trf1 and Trf2 protein were induced by H2O2. Co-treatment with fenofibrate (100 μM) significantly attenuated the reduction in RTL caused by H2O2 and GA and prevented Trf induction by H2O2. However knockdown of Trf1 and Trf2 expression using specific siRNA did not prevent H2O2 effects to lower RTL, thus implicating factors other than these Trfs alone in the fenofibrate protection against the H2O2 induction of RTL lowering. These in vitro findings demonstrate that diabetic conditions can induce telomere shortening and that fenofibrate has protective effects on telomere attrition, through as yet undefined mechanisms.
Sutanto SSI
Greg Brown Diabetes and Endocrinology Research Laboratory, Sydney Medical School (Central), Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia. Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
McLennan SV
Greg Brown Diabetes and Endocrinology Research Laboratory, Sydney Medical School (Central), Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia. Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia. NSW Health Pathology, Sydney, Australia.
Keech AC
Greg Brown Diabetes and Endocrinology Research Laboratory, Sydney Medical School (Central), Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
Twigg SM
Greg Brown Diabetes and Endocrinology Research Laboratory, Sydney Medical School (Central), Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia. stephen.twigg@sydney.edu.au. Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia. stephen.twigg@sydney.edu.au.
Journal of cell communication and signaling : 2019 Jun 15 pg
Sutanto, Surya Shin Ichi, et al. "Shortening of Telomere Length By Metabolic Factors in Diabetes: Protective Effects of Fenofibrate." Journal of Cell Communication and Signaling, 2019.
Sutanto SSI, McLennan SV, Keech AC, et al. Shortening of telomere length by metabolic factors in diabetes: protective effects of fenofibrate. J Cell Commun Signal. 2019.
Sutanto, S. S. I., McLennan, S. V., Keech, A. C., & Twigg, S. M. (2019). Shortening of telomere length by metabolic factors in diabetes: protective effects of fenofibrate. Journal of Cell Communication and Signaling, doi:10.1007/s12079-019-00521-x.
Sutanto SSI, et al. Shortening of Telomere Length By Metabolic Factors in Diabetes: Protective Effects of Fenofibrate. J Cell Commun Signal. 2019 Jun 15; PubMed PMID: 31203557.
TY - JOUR T1 - Shortening of telomere length by metabolic factors in diabetes: protective effects of fenofibrate. AU - Sutanto,Surya Shin Ichi, AU - McLennan,Susan Virginia, AU - Keech,Anthony C, AU - Twigg,Stephen Morris, Y1 - 2019/06/15/ PY - 2019/03/03/received PY - 2019/05/07/accepted PY - 2019/6/17/entrez PY - 2019/6/17/pubmed PY - 2019/6/17/medline KW - Diabetes KW - Glucosamine KW - Oxidative-stress KW - Premature-aging KW - Telomere JF - Journal of cell communication and signaling JO - J Cell Commun Signal N2 - People with diabetes mellitus have shorter telomeres compared with non-diabetic subjects. The aim of this study was to investigate an in-vitro model of telomere shortening under diabetes metabolic conditions. The mechanisms of the accelerated telomere length attrition and the potential telomere protective action of fenofibrate with related cellular mechanisms were also examined. Human dermal fibroblasts were passaged and cultured in normal (5.5 mM) or high (25 mM) D-glucose, across 7 days with hydrogen peroxide (H2O2), glucosamine (GA), or glycated albumin (AGEs-BSA). Relative telomere length (RTL) was determined by qPCR. The expression of shelterin complex members which regulate telomere stability were measured by qRT-PCR and Western immunoblot. Culture in high glucose decreased RTL compared with normal glucose: H2O2 and GA lowered the RTL after 7 days (each P < 0.05 vs untreated control), whereas AGEs-BSA had no effect compared with control-BSA. At day 7 the mRNA levels of most shelterin complex members, were induced by H2O2 and to a lesser extent by GA. Trf1 and Trf2 protein were induced by H2O2. Co-treatment with fenofibrate (100 μM) significantly attenuated the reduction in RTL caused by H2O2 and GA and prevented Trf induction by H2O2. However knockdown of Trf1 and Trf2 expression using specific siRNA did not prevent H2O2 effects to lower RTL, thus implicating factors other than these Trfs alone in the fenofibrate protection against the H2O2 induction of RTL lowering. These in vitro findings demonstrate that diabetic conditions can induce telomere shortening and that fenofibrate has protective effects on telomere attrition, through as yet undefined mechanisms. SN - 1873-9601 UR - https://www.unboundmedicine.com/medline/citation/31203557/Shortening_of_telomere_length_by_metabolic_factors_in_diabetes:_protective_effects_of_fenofibrate L2 - https://dx.doi.org/10.1007/s12079-019-00521-x DB - PRIME DP - Unbound Medicine ER -
Shelterin differentially respond to oxidative stress induced by TiO2-NPs and regulate telomere length in human hepatocytes and hepatocarcinoma cells in vitro.
Telomere protein RAP1 levels are affected by cellular aging and oxidative stress.
Shorter telomeres in adults with Type 1 diabetes correlate with diabetes duration, but only weakly with vascular function and risk factors.
Telomere length is shorter in affected members of families with familial nonmedullary thyroid cancer.
Weight loss associated with bariatric surgery does not restore short telomere length of severe obese patients after 1 year.
The aging lung: tissue telomere shortening in health and disease.
TRF1 as a major contributor for telomeres' shortening in the context of obesity.
The effect of pro-inflammatory conditioning and/or high glucose on telomere shortening of aging fibroblasts.
Telomere length, telomerase expression, and oxidative stress in lead smelters.
Modulation of telomere shelterin by TRF1 [corrected] and TRF2 interacts with telomerase to maintain the telomere length in non-small cell lung cancer.


text:
Q: MVC2 binding data to view model super slow when using JSON and collections I followed the http://haacked.com/archive/2010/04/15/sending-json-to-an-asp-net-mvc-action-method-argument.aspx blog on how to setup binding json data to a ViewModel.  seems to work.
The problem is that it is super slow. A collection with 200 entries in it and 8 fields per entry takes 3 minutes to even reach a break point at the beginning of controller.  Just 1 or 2 entries take very little time.  The only thing I know of that is happening between submit and reaching the controller is data binding to the ViewModel.  I don't know if MVC2 provides a good way to send this much data and bind it. I also suspect using x-forms data, instead of json, and creating custom binders would run me into the same problem.  Any Ideas?

A: I would try submitting your json to the controller action as a single string and then deal with parsing json explicitly in your own code... and skip model binding all together...

A: I'm not sure if this helps anyone, but my binding issues seem to have been resolved.  I'm not sure exactly what the problem was.  I made a design change to minimize the problem (only sent changed data over the wire).  This put off the problem.  However, recently I had to implment something that does generate a lot of data that needs to be bound and I had no binding lag. So not sure what fixed it.
The only thing I can think of is that I found out that JSON variable casting is not necessary in the request.
data={"pkid":"86"} as opposed to data={"pkid":86}
Actually casting the JSON was causing problem with some data types and so now I use all strings in the request, which so far MVC2 bind very well.
So I'm not sure if this fixed the huge binding lag or if some other application/Server configuration fixed it.  If anyone has this problem try it out and confirm.

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774. It wasn't anything I thought consciously about; it had appeared in my mind's eye without so much as a breath of effort. I waited patiently for the page to load and for the chime indicating that I had new mail to go off. It sounded. 774. I smirked, unsurprised, and clicked on the first new piece; this had happened before.
For as long as I can remember I've had an uncanny, nearly-unconscious precognitive ability. It is not something that I have ever been able to hone, nor have I ever tried to obtain mastery over it. It would be nice to know what number would come up next at a roulette table or what the blackjack dealer was holding...but somehow that doesn't seem right; it's not how things are supposed to go.
I call it a parlor trick of the mind, or, at times, a psychic twinkle. More often than not, it manifests itself in innocuous, meaningless ways. I've lost count of how many times I've woken up in the middle of the night, wondering what time it was, then seeing a number in my mind's eye, and either rolling over to see that exact time or the clock or waiting a few minutes and then experiencing the same thing. Sometimes it's the temperature on the thermostat (I'll know that it's 72 degrees upstairs before I get up there, for example), or, as it was today, some other random number like the amount of mail I keep saved in my AOL inbox.
All of that, though, pertains to the parlor trick aspect of it; the psychic twinkle episodes have been a bit more arcane. I've had moments of precognition where I reach for my cell phone a second before it rings; on a few of those occasions I was even thinking of the person who called or texted me right before the phone went off. The most common way that the psychic twinkle seems to make itself known is also the least explainable. On dozens of occasions I have thought of someone, either a friend or a family member, and knew that something had just happened to them. Sometimes it's something positive, like finding out about passing test scores, or getting good news, but more often it's not. Usually I get a funny feeling that something unsettling or upsetting has just happened to that person and, when I speak to them later on, I'll ask them if everything is okay. Depending upon the strength and clarity of the feeling, I'll offer details as well. The result is often a moment of surprise or shock followed by confusion and then an explanation for what happened and a question as to how I knew; I'm almost never wrong.
The single most bizarre experience that I have had like this involved a dream. I hadn't seen nor spoken to my brother for a few months as he was out to sea with his naval unit. One night I had a dream that I was standing with him atop a docked submarine. It was night and nearly pitch black; we were both wearing dark-colored pea coats. The frigid air flew in wisps away from his mouth as he spoke to me, unconsciously lifting his gloved hands to his mouth and blowing on them for additional warmth. I had a foreboding feeling throughout the dream and, at the end, he said goodbye to me and walked up a strange, spectral staircase that led skyward from the submarine. I woke up in tears fearing that he had died. When I calmed down I realized that I was reading too much into the dream; still, though, the feeling gnawed at me, persisting and growing in intensity--something had happened.
Finally, when I could stand it no longer, I called my sister and asked if she had been in contact with our brother. Detecting the heightened emotion in my voice, she said yes and asked me why I was asking. I told her that I had a feeling that something bad had happened to him, that he was injured or somehow endangered. She remained silent on the other end of the line for a few tense moments before informing me that the previous night (when I had had my dream), my brother had slipped while performing a watch atop the docked submarine and injured his back. She was as amazed as I was by the prescience of my dream.
Though I have had other far more fantastic experiences than the aforementioned dream, I must turn away from my reminiscences and focus instead on the purpose I wished to elucidate through this entry. It goes without saying that there is much that we do not understand about ourselves and the world we live in. It also goes without saying that children have far more active and lively imaginations than we do. What I found myself wondering early this morning, though, is whether or not children are more attuned to such supernatural phenomena and, if so, what types of experiences do they have? Their version of "normal" differs greatly from that which we, as adults, are conditioned to accept. Is it truly that children's imaginations are more powerful than adults'...or is it simply that we must turn our faculties away from that which is viewed as fanciful or whimsical and instead use our brain power to focus on the banalities of balancing budgets and drafting weekly shopping lists?
I ponder these things because, as I look at my son, sleeping serenely, I can't help but wonder...what secrets of the universe is he privy to that go unseen or unnoticed by the rest of us? I have watched him sleep hundreds of times in his three months of living and, as early as his first few days of life, his eyes darted to and fro behind his lowered lids; he was dreaming, or so it seemed. Researchers can offer only their best of postulations as to what babies dream of, positing that it is their daily experiences that are being relived in their sleep. I've spent entire days with Timmy where nothing out of the ordinary has happened and yet as he sleeps he will let out a whimper, clenching his face as if in great fear. Was he recalling a series of faded shapes swirling before his face from earlier in the day...or was it something else?
Perhaps there is something to be said for reincarnation. I've long since wondered if babies are born with recycled souls, so to speak. They cannot move nor can they speak for a relatively predictable range of time, one that is undeniably tied into their physiological and neurological development...but what if it's something more? I've played around with the theory that during the period that infants cannot speak they are going through a process of forgetting the memories of their past lives. It could explain why infants have bad dreams or why they dream at all. It could also explain why many of us have those metaphysical moments of remembering something that has never happened to us before. Of course, it could also simply be neural impulses that have nothing to do with such fringe-science worthy topics; it is all subjective anyway.
Still, I cannot help but wonder whether or not Timmy sees, hears, feels, or otherwise experiences things that both Heather and I are oblivious to. I have had scores of eerie experiences throughout my life where I have felt an unseen presence in the room with me. During the first week that Heather and I lived in our apartment after moving in, we heard someone coming up the steps from the first floor up to the main level of the apartment, and then up to the loft where we were sitting. The footfalls were deliberate and unmistakable; this was not an old house settling. Both of us feared that someone had broken into the apartment as we heard the footsteps reach the landing directly in front of us...and yet no one was there. The sound stopped as the last step was trod upon--the one that was level with where we sat. We sat in pensive silence, holding our breaths, waiting to see what, if anything, would materialize...and then we felt nothing. It was as if whoever or whatever it was wanted simply to scope out the new tenants living in the house.
I bring up the previous point because Timmy has exhibited signs of detecting an unseen visitor in the house on a few occasions. Once, while Heather and I were sitting and playing with him on the floor, he looked up with mild surprise and proceeded to turn his eyes across the room behind us, as if following a moving figure. He fixed his gaze at a point on the other side of the room where, naturally, there was no one, and he remained staring for a few seconds with his head cocked before turning his attention back to us. We have had guests over who have held Timmy when, suddenly, he will look up and past them, as if watching someone who is standing, unseen, directly behind them. One of our friends picked up on this and even asked if there was someone behind him (incidentally, this is a person who has shared in many fantastic and unexplained phenomena with me in the past, so this type of thing is nothing new to him).
I suppose I will have to wait until Timmy can speak to get a better sense of what he sees and hears. If my experiences with uncontrolled paranormal activity (such as the mental parlor trick and psychic twinkle), as well as those that were controlled (a perfect record of twenty-five for twenty-five with Tarot predictions, for example; it's been years since I've dabbled with the cards--I put them down because it didn't feel right...it was as if I was divining the future using some sort of dark power. The feeling was both unnerving and addicting), it might suggest that I am either predisposed or inclined to such things. I do not think that there is anything unique or special about me and would offer that I am probably only mildly more open to these sorts of happenings than other people. Then again, it could all just be in my mind anyway.
Somehow, though, I don't think that that is the case. I'm looking forward to seeing if my son shares in any of these experiences but, if he doesn't, at least I'll be able to tell whether or not he's late coming home when he's a teenager...all without looking up at the clock!