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Lonza leader outlines small-molecule trends for 2021 and beyond
By Jenni Spinner contact
06-May-2021 - Last updated on 06-May-2021 at 15:18 GMT
(howtogoto/iStock via Getty Images Plus)
Related tags: Lonza, CDMO, Pharmaceutical formulation, Small molecule drugs, Research
The head of small-molecule business for the pharma solutions specialist talks about obstacles, and how companies can work to clear them for future success.
COVID-19 certainly has created unique challenges for the pharmaceutical industry, but the pandemic is not the only factor making the job of a life-sciences professional more difficult than ever. Rapid technological evolution, changing global conditions, and increasing pressure to get treatments from idea to market launch rapidly also are impacting the field.
Gordon Bates, president of small molecules for Lonza Group, recently shared his perspective on the various forces impacting the industry, and how professionals in the field are rising to the occasion.
OSP: What challenges and opportunities are small-molecule manufacturers and developers facing today?
GB: We continue to see small molecules being the predominant technology and products that are approved in the clinical pipeline, so that is leaving us feeling really positive.
Small molecules will continue to be the number one new technology for new products being approved, and about two-thirds of them are on accelerated pathways of one designation or another. More and more, we see smaller companies commercializing themselves, where perhaps 10 years ago, these smaller companies may have sold much earlier in development to a larger pharma.
The opportunities and challenges are very close to each other. Smart, smaller companies don't have so many people on their teams, and they rely heavily on outsourcing--not just for access to resources, but also for the quality of conversations that they're having with our team.
At Lonza, we have great heritage and experience in the number of molecules that we've developed and that we've taken successfully through commercialization. That helps small companies who perhaps don't necessarily have all that expertise, or their expertise is in one specific area, and we see them using consultants to help close those gaps.
As I mentioned, two-thirds of those molecules approved in 2020 were on an accelerated pathway. The ability to be able to move quickly, or slow down if necessary, or move at the same pace that our customer wants to move, to be able to ramp up activities quickly and know what to do, or accelerate to get through to commercialization, that certainly is a challenge. It's also an opportunity for those that can move quickly and that can help those smaller customers through that process.
OSP: How does the Lonza service model flex to support the requirements of small and emerging companies?
GB: More and more large pharma is working in collaboration with smaller companies on their development programs, or even perhaps being an investor in some of these companies. I don't see it as kind of a competition; it's more that large pharma has started thinking about different ways in which they can work to further innovation needs.
From our perspective, about 90% of our customers are what we would call small customers—and we have a lot of customers. We see the kind of guidance and support they need, and I think having the capacity to be able to respond quickly is a real challenge that we need to balance.
Mostly, what I hear when I talk to people is that many of the lead CDMOs, those with great track records are extremely busy. I hear that the capacity is tight, and not having the capacity to be able to move at the pace that smaller companies want to move when they get great data readout, or perhaps they get other funding, that challenge of being able to be flexible and accommodating with what's important to their business, or what's important to our business model.
And here, you know, I think that simply comes down to do you talk to the customers enough to really understand what the key drivers are in the business, and perhaps demonstrating that empathy and understanding what the drivers are to be able to adapt and move at the pace that they want to move.
OSP: Do you find it's harder to have those conversations now that COVID has impacted the industry?
GB: You know, none of this technology is new. You're speaking to someone who's spent the last 10 years every week on an airplane, so to not have been on an airplane since March of last year is a strange experience for me.
When the pandemic first reached the West, there was a bit of a slow down for a couple of months, then things pretty quickly got back to a normal level of activity in demand. We did several things which were really exciting because they've challenged (if we ever get to a new normal) how we'll think about them in the future.
Firstly, because I couldn't travel, I wasn't spending as much time talking to customers, so we invited customers to participate in our leadership team meeting and dial in; that's been a spectacular success that the customers have been able to participate, have a seat at the table and give us feedback on how we're doing or what opportunities could come through.
Another part of it that's been really interesting is how the sites have responded to setting up virtual visits and audits. We provided all the technology needed to support that, but the creativity that came from the sites of how to actually conduct a virtual audit—imagine you're talking in a room one minute, then you want to hand over to someone in the laboratory or in the factory—they choreographed this so fantastically well to keep it flowing, that it felt like a really immersive experience.
Adapting and learning different ways and new technologies to be able to support that, changes our thinking going forward forever.
I don't feel as though I'm missing out and having fewer conversations now because we've embraced the technology so much. This actually brings a different level of intimacy to relationships, When I'm talking to customers, they can see my house, or if my dogs run past and bark in the background or my kids come and pick something up off the printer. I've met people's husbands and kids. I've had a tour of someone's boat, and of someone's cabin. It changes the dynamic and intimacy is an interesting point.
OSP: What market trends do you expect in 2021 and over the next several years in small molecule? How do you advise pharma and biotech to capitalize on these trends?
Gordon Bates, president of small molecules, Lonza Group
GB: Using the technology will actually become a little bit more than the norm. The growth of specialty medicines, where we see smaller volumes than traditionally experienced in the past and accelerated timelines, are more and more migrating into those types of supply chains that don't have special breakthrough designations. That speed is becoming the new norm.
Smaller companies are continuing to own most of those pipeline products coming through, and outsourcing as a result of that. I don't know whether the location of manufacturing will become more of a topic; we're seeing more and more people talking about manufacturing within national boundaries, as opposed to in the global environment, but it's hard to judge how that will play out.
In my area of responsibility, Lonza Small Molecules, our integrated network is globally located from China to Oregon.
The EU made a list of medicines that they would like to be manufactured within their boundaries. We have a very healthy presence of a footprint in the US, but what we don't have is drug substance in the US, and that is an area that we continue to explore in small molecules. We have strong investments that we're making in small molecule and large molecule, and we're extremely proud of the role that we play in supporting some of the vaccine production work that's going on in development programs as well.
OSP: How are CDMOs like Lonza helping accelerate development of innovative drug products to trials and to patients?
As referenced earlier, more drugs are getting some form of accelerated designation. When you've got robust processes of how you are able to take those through development cycles, the regulatory support that you can provide, pitfalls that you've seen elsewhere, you're able to bring all of those experiences with the processes that you have. You can offer regulatory support, you can offer clinical packaging and distribution capability. The ability to have all of that in one house is something that definitely helps with particularly smaller companies that want to accelerate.
The ability to come to a company that has all of those services helps. One of the challenges to make sure that you're successful in moving more quickly because it's always the handoffs between one step and another that either slow down or have the greatest propensity to have risk. Our intent is to be able to co-locate drug product and drug substance development on one site to get rid of all of that complication or on logistics.
OSP: Is there anything else you want to add about developments in personalized medicines and how Lonza is helping clients facilitate growth and innovation in that space?
Our estimate is about 30% of pipelines require highly potent manufacturing capability. We have made multiple investments in HPAPI capacity over the last several years, primarily at our Visp site. More recently, in April 2021 we announced a new manufacturing complex for small molecules, including antibody drug conjugate payloads, at our site in Visp, Switzerland.
We also see that 70% of these molecules require some degree of solubility or bioavailability improvement; we have multiple technologies that support making drugs that in the past weren't considered to be druggable. By applying these technologies, to be able to resolve those bioavailability challenges or bring a different technology that perhaps makes a drug druggable is possible. We have a facility in Bend, Oregon, and it's probably one of the industry-leading shops for supporting and bringing different technologies to resolve bioavailability challenges. In November 2020, we made significant new investment in 12 new suites, including our Bend facility, because our commercial portfolio is evolving and it's consuming more capacity.
We're going to add more clinical capacity to address that trend of bioavailability and solubility challenges. We have a high degree of expertise, and we're adding capacity to be able to support clinical pipelines in that direction. It's kind of a nice problem; we're seeing more products being commercialized there, so we need more capacity to support clinical, rather than seeing it being consumed by clinical and commercial.
OSP: How does Lonza plan to keep ahead of the competition?
GB: Almost anyone can buy the equipment, almost anyone could sink capital into the ground, in any part of the world. The things that make the difference in how you work with customers are your technical competence, which comes from the experience that you have in the teams, and making sure that we attract to continue to develop great people that can help solve those complex problems.
Most important is asking, what's that customer journey like? Do they have a great experience when they're with us, both from a perspective of helping solve problems, but also feeling like we really care and that we listen. It comes down to the caliber of people and the conversations that you have, and how that experience makes a difference.
It's a competitive advantage to be able to have that great customer feedback. We test feedback all the time in various different mechanisms because you run the risk of living in an ivory tower otherwise. It's a great way of connecting so that you stay in the reality of how customers feel from a technology perspective. We continue to invest, to say what technologies we think are important to be able to solve some of those challenges.
Related topics: Preclinical Research, Contract Manufacturing & Logistics, Bioavailability Challenge, Processing equipment, Drug delivery, formulation, Delivery formulations, Contract Manufacturing, Analytical testing, QC
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6459 Хідесан (6459 Hidesan) — астероїд головного поясу, відкритий 28 жовтня 1992 року.

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LGBTQ community comes out
Hillary Hetrick, @hillarymhetrick
Los Medanos College Allies Club and LMC faculty from the LGBTQ community celebrated "Coming Out Day," an event that addresses LGBTQ issues and encourages community visibility. Three faculty members told their coming out stories during the event. The event also showcased Deb Cuny, a Restorative Justice Coach from Oakland who is part of the #BornPerfect Campaign whose goal is to end Conversion Therapy.
English instructor Liz Green gave a warm welcome to the audience.
"You're not just at any National Coming Out Day," she said. "You're at the 30th anniversary."
After sharing the agenda for the evening, she continued by explaining the importance of "coming out."
"By coming out to our family and to our friends, colleagues, coworkers, we're making our community visible, and we're creating a sense of safety and coming out of isolation," Green explained. "There's all these different levels in which coming out happens and it's a life-long process."
Green gave way for the next speaker, English instructor Jeff Mitchell Matthews. He gave his told his coming out story after giving a brief history of his career at Los Medanos College. He has been at Los Medanos since 1992.
"For many, many years I was the only fag on campus, as I used to put it," Mitchell Matthews said.
Matthews gave a detailed description of programs and services on campus that help students in the LGBTQ community and emphasized the new LGBTQ studies degree for transfer the college is offering.
"Our LGBTQ programs here on campus have been firmly established," said Mitchell Matthews
Liz Green returned to read a poem she wrote about coming out as a bisexual. Then she and Library staff member Catt Wood placed a chocolate cake with candles at the front of the room and sang "Happy National Coming Out Day" to the tune of "Happy Birthday."
The stage was turned over to the main speaker Deb Cuny. Cuny gave her coming out story. with the cake as a prop.
"With a cake and a celebration comes candles, and with candles come wishes and I have quite a few wishes I want to share tonight. And I invite you to make a wish," Cuny said.
There were 12 wishes corresponding with 12 parts of Cuny's coming out story. As a person who was raised in the Christian faith, her family and church was homophobic and initially could not accept her sexual orientation. Her family did everything to enforce gender roles, like making her wear hair bows when she played sports. She said that she liked dressing in her father's clothes, had ambitions of becoming a preacher and often was found preaching with a bible to a line of stuffed animals.
As a teenager, Cuny tried to seek help from her youth group leaders.
"I turned to them and told them about my same-sex attractions," Cuny said.
She was appalled when the people she trusted for help abandoned her. Her church rejected her, her parents refused to accept her and joined anti-gay organizations. After a downward spiral of anxiety, depression and resorting to alcohol dependence, she felt she was powerless and needed help. Again she reached out to her parents and finally things began to get better.
"It is by the grace of God that I am standing here today four years sober," she said.
Her parents redeemed themselves and no longer partake in homophobia. Cuny said her mom changed her focus because she just couldn't understand why her faith system didn't align with what she knew about her daughter.
"My mom is now part of a group called the Mama Bears, and the Mama Bears focus on how to love their queer kids," Cuny explained.
The Mama Bears go to events and offer love to queer people who need a supportive parent.
"I am finally proud to be queer and Christian," said Cuny.
Before she ended the presentation, she addressed why she came out.
"I do it for my sanity, for my sobriety and to reclaim my power which means not hiding or apologizing for what makes me so goddamn beautiful," she said, "and I'm beautiful."
Hillary Hetrick, Campus Editor

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Sith gun robh so…
What this blog is all about?
El Nino looks set to be strongest ever
September 13, 2015 September 13, 2015 5 Comments
These folks had checked weather within 24 hours – still were caught
The developing El Nino is stronger than the last major event of its type in 1997.
According to the US National Oceanographic and Atmospheric Administration (NOAA) and the UK Met Office, this El Nino is shaping up to be the strongest since records began in 1950.
El Nino is a natural phenomenon which occurs every two to seven years and lasts between six and 18 months.
It manifests as a warming of the surface waters of the eastern equatorial Pacific Ocean. The current El Nino is so strong that in some areas sea surface temperatures (SSTs) are more than 2 degrees Celsius above the long-term average.
Aside from the devastating effect that El Nino has on the Peruvian fishing industry, the real significance lies in the change in weather patterns that it produces around the globe.
In the Pacific, the warmer waters in the eastern part of the ocean have spawned more typhoons, super typhoons and hurricanes than usual, with the tracks of those storm systems also being altered considerably. Severe weather conditions have been experienced around the Asia-Pacific region…
In North America, where much of the south and west has been experiencing the worst drought in a century, the El Nino could bring the benefit of rain, although if the El Nino of 1997-98 is anything to go by, that rain could result in severe flooding and deaths.
Yup. Here in New Mexico, many look forward to El Niño. Snowier winters bring lots of tourists to the best powder skiing in the United States. In high desert country, more moisture is always welcome. As long as people are bright enough to stay out of arroyos and away from flash flood danger, the additional precipitation is beneficial.
In the Caribbean, the developing El Nino has already had the opposite effect to the one experienced in the Pacific: namely, it has reduced hurricane frequency by causing an increase in wind shear. This is a change of wind direction and speed with height that can disrupt hurricane formation.
In Africa, El Ninos are associated with drought across southern portions of the continent, and drought in countries such as Zimbabwe, Botswana and South Africa is causing a looming food crisis.
Even Europe is not immune from the effects of an El Nino. If this year's event follows the pattern of previous ones, then winter weather here could be colder and drier than average and last well into spring.
Regular readers down in Oz are well aware of the dangers El Niño brings to their part of Earth. The fire danger experienced there can be the worst on the planet.
No two El Ninos are the same. There are lots of other short and long-term variables in the global weather patterns, but the coming months could see some unusual and spectacular weather in many parts of the world.
Cleanup suspended at 10 mine sites since the Silverton spill
Click to enlarge — La Plata County, CO
AP EXCLUSIVE
Site investigations and some cleanup work at 10 polluted mining complexes in four states were suspended because of conditions similar to those that led to a massive wastewater blowout from an inactive Colorado gold mine, U.S. Environmental Protection Agency officials said.
The sites include three in California, four in Colorado, two in Montana and one in Missouri, according to details obtained by The Associated Press following repeated requests for the information.
They have the potential for contaminated water to build up inside mine workings, EPA Assistant Administrator Mathy Stanislaus said. That would set the stage for a possible spill such as last month's near Silverton, Colorado, where an EPA team triggered a 3 million gallon blowout of toxic sludge while doing excavation work on the inactive Gold King Mine.
The accident fouled rivers in three states and attracted harsh criticism of the EPA for not being prepared despite prior warnings that such a spill could happen…
Cleanup efforts on some of the mines have been going on for years yet remain unfinished, underscoring the complexity of a long-running attempt to address an estimated 500,000 abandoned mines across the U.S. Work on others was in the early stages.
In a report to Congress delivered Friday, the Government Accountability Office said federal agencies identified thousands of contaminated mine sites in recent years — even as their attempts to assess what harm is being done to people and the environment have lagged.
Further investigations were needed to gauge the danger posed by the 10 mining complexes under the suspension before work could safely resume…
That includes categorizing their level of hazard. For those deemed a "probable hazard," the EPA plans to keep the work stoppage in place until emergency plans are drawn up to deal with any accident…
The Aug. 12 stop-work order from EPA Administrator Gina McCarthy did not apply to sites where halting operations would pose a threat to people or increase the potential for harm to the environment, according to internal EPA documents.
Also exempted were portions of the 10 stopped projects where construction already was completed, such as treatment systems for contaminated water that pours continually from many abandoned mine shafts.
RTFA for a bit more detail on the additional sites, location, etc.. As well as the updated, upgraded emergency procedures added by the EPA's cleanup contractor.
Feds drop charges against professor – Scientific reality beats Cold War bigots
Xi Xiaoxing, the chairman of Temple University's physics department – David Maialetti/Philly.com
When the Justice Department arrested the chairman of Temple University's physics department this spring and accused him of sharing sensitive American-made technology with China, prosecutors had what seemed like a damning piece of evidence: schematics of sophisticated laboratory equipment sent by the professor, Xi Xiaoxing, to scientists in China.
The schematics, prosecutors said, revealed the design of a device known as a pocket heater. The equipment is used in superconductor research, and Dr. Xi had signed an agreement promising to keep its design a secret.
But months later, long after federal agents had led Dr. Xi away in handcuffs, independent experts discovered something wrong with the evidence at the heart of the Justice Department's case: The blueprints were not for a pocket heater.
Faced with sworn statements from leading scientists, including an inventor of the pocket heater, the Justice Department on Friday afternoon dropped all charges against Dr. Xi, an American citizen.
It was an embarrassing acknowledgment that prosecutors and F.B.I. agents did not understand — and did not do enough to learn — the science at the heart of the case before bringing charges that jeopardized Dr. Xi's career and left the impression that he was spying for China…
…Dr. Xi's case, coming on the heels of a similar case that was dismissed a few months ago in Ohio, raises questions about whether the Justice Department, in its rush to find Chinese spies, is ensnaring innocent American citizens of Chinese ancestry…
The science involved in Dr. Xi's case is, by any measure, complicated…Dr. Xi's lawyer, Peter Zeidenberg, said that despite the complexity, it appeared that the government never consulted with experts before taking the case to a grand jury…
And the grand jury did what grand juries always think they're required to do. They handed over an indictment.
Mr. Zeidenberg, a lawyer for the firm Arent Fox, represented both Dr. Xi and Sherry Chen, a government hydrologist who was charged and later cleared in the Ohio case. A longtime federal prosecutor, Mr. Zeidenberg said he understood that agents felt intense pressure to crack down on Chinese espionage, but the authorities in these cases appeared to have been too quick to assume that their suspicions were justified.
In Dr. Xi's case, Mr. Zeidenberg said, the authorities saw emails to scientists in China and assumed the worst. But he said the emails represented the kind of international academic collaboration that governments and universities encourage. The technology discussed was not sensitive or restricted, he said.
"If he was Canadian-American or French-American, or he was from the U.K., would this have ever even got on the government's radar? I don't think so," Mr. Zeidenberg said…
About a dozen F.B.I. agents, some with guns drawn, stormed Dr. Xi's home in the Philadelphia suburbs in May, searching his house just after dawn, he said. His two daughters and his wife watched the agents take him away in handcuffs on fraud charges…
Temple University put him on administrative leave and took away his title as chairman of the physics department. He was given strict rules about who at the school he could talk to. He said that made it impossible for him to continue working on a long-running research project that was nearing completion.
Last month, Mr. Zeidenberg delivered a presentation for prosecutors and explained the science. He gave them sworn statements from the experts and implored the Justice Department to consult with a physicist before taking the case any further. Late Friday afternoon, the Justice Department dropped the case "in the interests of justice."
Nice of the DOJ finally to get round to consideration of justice – instead of continuing to act like obedient little blue minions on the payroll of a government committed to unrelenting Cold War ideology. Our political leaders – the two flavors we're allowed – are dedicated to the imperial ideal we took over from a poverty-stricken British Empire after World War 2. That this ideology leads the United States further down the path of economic and social corruption is of no concern. That lives and careers may be crushed by bureaucrats is of no concern.
The bigotry and racism that is a central characteristic of American culture is no less strong in our system of justice than daily life. If Professor Xi tried too hard to stand up for his rights, his innocence, he could have died at the stroke of a moment's decision made by FBI agents with guns drawn.
Thanks, Ian Bremmer
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Letters to Amelia
By Lindsay Zier-Vogel
Grace Porter is reeling from grief after her partner of seven years unexpectedly leaves. Amidst her heartache, the thirty-year-old library tech is tasked with reading newly discovered letters that Amelia Earhart wrote to her lover, Gene Vidal. She becomes captivated by the famous ... Read more
Grace Porter is reeling from grief after her partner of seven years unexpectedly leaves. Amidst her heartache, the thirty-year-old library tech is tasked with reading newly discovered letters that Amelia Earhart wrote to her lover, Gene Vidal. She becomes captivated by the famous pilot who disappeared in 1937. Letter by letter, Grace understands more about Amelia while piecing her own life back together.
When Grace discovers she is pregnant, her life becomes more intertwined with the aviation hero and she begins to write her own letters to Amelia. While navigating her third trimester—amidst new conspiracy theories about Amelia's mysterious disappearance, the search for her remains, and the impending publication of her private letters—Grace goes on a pilgrimage of her own.
Underscoring the power of reading and writing letters for self-discovery, Letters to Amelia is, above all, a story of the essential need for connection—and our universal ability to find hope in the face of fear.
Praise for Letters to Amelia:
"Brimming over with Lindsay Zier-Vogel's obvious love for the story of Amelia Earhart, Letters to Amelia is a wonderful novel about flight and passion, about love-letters and reaching out; a novel about how we never know quite what's coming next, but still keep launching ourselves into the blue tomorrow. "—Jon McGregor, author of Reservoir 13
"A tender portrait of heartbreak and a thoughtful ode to new motherhood. Letters to Amelia is an endorsement of finding our own ways to heal, and a celebration of that big, messy, wonderful journey of coming into one's own. Charming and beautifully rendered, this is a big-hearted hopeful novel, full of life and love. " —Stacey May Fowles, author of Baseball Life Advice: Loving the Game that Saved Me
"When we think of Amelia Earhart, we think enigmatic adventurer and feminist pioneer—and, of course, of her mysterious disappearance. But in Letters to Amelia, we meet a different Amelia Earhart, as seen through the eyes of Grace, the novel's protagonist, a young library tech tasked with reading her letters: an Amelia who is funny, charming, joyful, sad, and most of all, full of life. Zier-Vogel writes with uncanny empathy about heartbreak, friendship, motherhood, and the common threads that connect women across time, geography, and even between earth and sky. Letters to Amelia is a gorgeous, big-hearted debut that will make you feel like you are flying, and Zier-Vogel is a writer whose career is about to soar. " —Amy Jones, author of Every Little Piece of Me
"Letters to Amelia invites us to hold our heroines close and to take heart – it is gentle and joyous, full of tenderness, alive and sturdy with hope. " —Anne Michaels, author of Fugitive Pieces and The Winter Vault
Lindsay Zier-Vogel
Lindsay Zier-Vogel is a Toronto-based writer, arts educator and the creator of the internationally-acclaimed Love Lettering Project. After studying contemporary dance, she received her MA in Creative Writing from the University of Toronto. Her writing has been widely published in Canada and the U.K. Since 2001, she has been teaching creative writing workshops in schools and communities. Her hand-bound books are housed in the permanent collection at the Thomas Fisher Rare Book Library in Toronto. As the creator of the Love Lettering Project, Lindsay has asked people all over the world to write love letters to their communities and hide them for strangers to find, spreading place-based love. Lindsay also writes children's books. Because of The Love Lettering Project, CBC Radio has deemed Lindsay a "national treasure." Letters to Amelia is her first book.
NaNoWriMo: 22 Tips & Tricks from Writers
For National Novel Writing Month aka NaNoWriMo, we rounded up 22 tips and tricks from established writers, including a two-time winner of the 3-Day Novel Contest, to encourage and unlock your creativity.
Test Kitchen: Little Red Bus
This edition of Test Kitchen pays homage to Amelia Earhart, whose love letters in Lindsay Zier-Vogel's charming, big-hearted epistolary novel Letters to Amelia (Book*hug Press) propel the story's protagonist to go on a pilgrimage of her own. Scroll down to get the recipe ... Read more
Dimensions 200 pages, 5.25 x 8.00 x 1.00 in
Publisher Book*hug Press
Category Fiction
Keywords Epistolary , Contemporary Women , Literary


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Moradi () is a surname. Notable people with the surname include:

Ali Akbar Moradi (born 1957), Iranian musician
Amir Moradi (born 1990), Iranian middle-distance runner
Elshan Moradi (born 1985), Iranian chess grandmaster
Houshang Moradi Kermani (born 1944), Iranian writer
Jafad Moradi (born 1984), Iranian football player
Masoud Moradi (born 1965), Iranian football referee
Mike Moradi, American biochemist, entrepreneur and diabetes advocate
Mohammad Jafar Moradi (born 1990), Iranian long distance runner
Sajjad Moradi (born 1983), Iranian middle distance runner
Shahmirza Moradi (1924–1997), Iranian sorna player
Sohrab Moradi (born 1988), Iranian weightlifter
Zak Moradi (born 1990), Kurdish-Irish hurler
Zaniar Moradi (1987–2018), executed Kurd political prisoner

See also
Moradi (disambiguation)
Moradei
Morandi
Mouradian (disambiguation)


text:
Apycom Java Applets
LLANELLI AFC
Nicky Tucker
STRIP 1
Red shirts, Red shorts, Red socks
Yellow Shirts, Blue Shorts & Yellow Socks
Promoted to League of Wales, 1999. Highest finish 5th (2000/1). Relegated 2003 but returned as Welsh League champions 2004.
BEST LoW WIN
11-0 v Oswestry Town 04/04/01
WORST LoW DEFEAT
1-10 by Inter Cardiff 25/01/94
0-9 by Connah's Quay Nomads 08/10/94
MOST GOALS IN LoW SEASON
21 by Mark Dickeson 1999/2000
20 by Gary Lloyd 1993/1994
MOST GOALS IN LoW MATCH
4 by Mark Dickeson v Oswestry Town 04/04/01
TOP SCORERS IN LoW
55 by Mark Dickeson (1992 – 2002)
34 by Gary Lloyd (1992 – 1995)
33 by Anthony Smolka (1994 – 1996)
23 by Phil Davidson (1992 – 2000)
MOST LoW APPEARANCES
144 (+1 Sub) by Mark Dickeson (1992 – 2002)
121 (+4 Sub) by Phil Davidson (1992 – 2000)
121 by Richard Thomas (1992 – 1996)
99 (+5 Sub) by Stephen Myers (1993 – 1996)
Stebonheath Park, Penallt Road, Llanelli, SA15 1EY
Capacity: 3700
Seats: 700
Highest LoW attendance: 1,410 v Barry Town 14/01/00
WEBSITE OFFICIAL http://www.llanelliafc.co.uk/
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From East: A484 from Swansea or M4 (junction 48), follow signs to Llanelli until Trostre roundabout (MacDonalds). Take Llanelli exit. First exit at next roundabout, first exit again at next roundabout into James Street.
From North: A476 from Llandeilo, through Felinfoel follow sign to Swansea. Second exit at roundabout into James Street.
From West: From M4 (junction 48). A484 from Carmarthen, via Pembrey, Burry Port and Pwll. You will eventually arrive at a sort of misshapen roundabout, follow sign to Swansea. Second exit at roundabout into James Street. Follow road to no through road signs straight on for Robbie James Stand, right for Social Club.
Llanelli was formed in 1896 and turned professional in 1912.
The history of the club since professionalism tells the story of participation in three leagues: the Southern League, the Welsh League and latterly the League of Wales, of which Llanelli were founder members.
Relegated in 1995/6, Llanelli returned to the fold in 1999 when Ton Pentre declined promotion and finished fifth in their first season back. Unfortunately, the club could not maintain this form and after escaping the drop the next year, they finished bottom in 2002/3.
Famous names to have played at Stebonheath Park include Jock Stein and Welsh international Robbie James.
CLUB HISTORY AND STATS: Llanelli AFC


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Home » Mobile first, patient first
Mobile first, patient first
Modernizing health care with Gigabit Wi-Fi opens new opportunities for medical device innovation
Rick Reid
With today's patient experiences linked more closely to mobility than ever before, an effective mobile strategy is now a critical part of any health care organization's success. What tools and devices can providers use to improve the quality of care? How will patients find their way around a facility? How can care efficiency be increased while reducing costs? The answers begin with deploying a wireless infrastructure that supports current and future care innovations.
With Wi-Fi infrastructure that may be more than a few years old, many health care organizations are struggling to keep up with increasing mobile connectivity expectations. With the Internet of Things (IoT) quickly changing workplaces across every industry, including health care, organizations are seeing more opportunities to improve patient care and boost customer service, while simultaneously achieving operational efficiencies.
Here's how three organizations are tackling these challenges and embracing opportunities right now.
Case 1: Boston Medical Center
Photo courtesy of Aruba
During its clinical campus redesign, Boston Medical Center (BMC) installed a robust, modern wireless local area network (WLAN) infrastructure to improve health care delivery throughout the 496-bed academic hospital's 30 existing buildings, including three facilities it was renovating and expanding.
"Having highly reliable, secure and pervasive coverage was key," says Craig Reise, manager of infrastructure engineering for the hospital.
Adopting Gigabit Wi-Fi. BMC began upgrading its network by installing access points (APs) that support the latest IEEE standard, 802.11ac, also known as Gigabit Wi-Fi, for providing wirelike experiences.
To eliminate dead zones in even the most challenging areas, such as lead-lined walls of the radiology room, BMC installed approximately 800 indoor and outdoor APs along with the latest generation of mobility controllers — where the Wi-Fi operating system, firewall and related applications reside.
BMC also leveraged a sophisticated mapping tool, supplied by its Wi-Fi technology partner, to determine the most advantageous locations for each AP. "Proper WLAN design and testing was critical to meeting our pervasive Wi-Fi goals," Reise says.
"For example, we recently moved our NICU to a new floor enabled with Gigabit Wi-Fi," Reise continued. "Our new [Hewlett Packard Enterprise] HPE Aruba infrastructure is supporting workstations on wheels, various wireless medical devices, an iPad-enabled language interpreter service, our Stanley Healthcare infant protection system and a new nurse call system using Ascom's Myco phones for Voice-over-Wireless and direct alarms from instruments attached to the babies."
Enterprise tools automate management. BMC also invested in enterprise management software that enables BMC's lean information technology (IT) staff to visualize every AP, as well as every device connected to each AP, from a centralized dashboard to monitor device behavior, troubleshoot application issues proactively and plan for capacity to meet new needs. Additionally, it can be used as a predictive tool to simulate situations, such as a flurry of devices connecting at shift changes.
To connect the myriad wireless devices on its campus, BMC is deploying the ClearPass Policy Manager from Aruba for secure network access. It will allow clinician and staff self-service onboarding and automatically puts different types of devices into different security roles.
For example, infusion pumps are only allowed to communicate with their own management servers. Sensors for an IoT infant-protection system receive an appropriate set of credentials. And providers signing into a cart-based wireless laptop can access BMC's EPIC system.
In addition to seamlessly connecting approximately 3,000 devices to the Wi-Fi network daily, the smart policy management platform will also segment the WLAN to create a separate guest network, replacing the manual configuration currently utilized to keep patient and visitor connectivity completely segregated from institutional traffic.
Adding a navigational app. Today, BMC's Wi-Fi supports multiple patient care-related applications for emergency, operating room and CPOE (computerized provider order entry) systems. Operationally, it powers a Vocera Communications Badge solution, a pneumatic tube control system, temperature sensors, security-related devices, locator tagging for high-value assets and a valet management system.
Reise notes that BMC plans to explore a branded app to assist patients, staff and visitors with wayfinding around its campus. The app will allow users to access a campus map and real-time locating data for quickly finding facilities and departments spread over several city blocks.
"With our new, secure WLAN in place, our IT staff can concentrate on projects that help BMC deliver exceptional patient care," he says. "And, we can do it while also reducing our overhead costs."
Case 2: Torrance (Calif.) Memorial Medical Center
Torrance Memorial Medical Center
Los Angeles County-based Torrance Memorial Medical Center's transition to 802.11ac on campus also includes innovative technology for extending Gigabit Wi-Fi to off-campus locations.
"A modern WLAN is mission-critical to our organization as we have grown to become a multifaceted health system," says Steve Lantz, director of IT infrastructure and operations for the 446-bed nonprofit medical center. "The demand for wireless is increasing not only on our main campus, but across our expanding network of physicians."
Zero-touch mobilizes remote sites. After replacing its aging wireless gear with approximately 750 new APs, Torrance Memorial also began outfitting remote physician offices with Instant APs from Aruba. Also called "controllerless," these units are zero-touch and self-provisioning, meaning a single, master AP communicates configurations to all similar APs.
What's more, Instant APs are plug-and-play, enabling nontechnical individuals to easily install them. This simplifies deployment and administration at remote sites, while providing the same reliability, security and performance as traditional, controller-managed APs.
In addition, a robust controllerless solution can automatically transfer critical controls from one Instant AP to another, ensuring no connectivity disruptions in the event of an AP failure — all without any human intervention.
New initiatives enabled. For security across all APs on its network, Torrance Memorial is also utilizing a smart policy management platform to separate guest and internal traffic. This supports the institution's hybrid device strategy, enabling Torrance Memorial to permit staff-owned, "bring your own device" gear, as well as corporate-issued tablets, laptops and wireless-enabled medical equipment, onto the network.
"Having policy management software that automatically detects the type of device seeking connectivity and then providing it with the appropriate credentials, allows us to deliver services securely," Lantz says. "Delivering access for staff, patients and guests while maintaining tight security is challenging, but our infrastructure provides a solid platform."
Torrance Memorial also appreciates its network management platform for ensuring the stability and reliability required to support skyrocketing device counts. In addition to institution-issued tablets, this includes wireless-enabled medical devices such as infusion pumps, Dolphin handheld barcode scanners, virtual desktop infrastructure-enabled mobile PC carts and mobile EKGs.
Continuous innovation. Moving forward, Torrance Memorial continues to plan for innovations that depend on modern Wi-Fi, such as expanding its Intouch Health virtual care program.
The organization will leverage its WLAN as a platform for mobile communications via smartphone. "This solution will provide voice, secure text messaging, access to patient information and other applications to help provide better, more efficient patient care," Lantz says.
Torrance Memorial also will be considering IoT connectivity as solutions mature.
"Our organization prides itself on having the expertise and technology to deliver the best medical care possible," Lantz says. "With our new Aruba Wi-Fi infrastructure in place, we have the foundation to do so."
Case 3: Kelsey-Seybold Clinic, Houston
Photo courtesy of Kelsey-Seybolda
Like BMC and Torrance Memorial, Houston's Kelsey-Seybold Clinic recently adopted an 802.11ac WLAN to enable its 420 health care providers to continue the organization's 75-year tradition of excellence while simultaneously reducing operational costs.
"As a leading U.S. physician-owned practice and the nation's first NCQA [National Committee for Quality Assurance]-accredited accountable care organization, we depend on our Wi-Fi to be responsive and stable," says Martin Littmann, chief technology officer and chief information security officer for the institution.
Improved security posture and more. Since it is a distributed organization, Kelsey-Seybold has deployed its WLAN throughout 20 locations spread across 10,000 square miles. To secure and manage this vast network, Kelsey-Seybold leverages the Aruba ClearPass Policy Manager platform for clinic-owned mobile devices, wireless medical hardware and employee-owned, bring-your-own-technology (BYOT) devices, as well as patient and visitor mobile connectivity.
This platform enables Kelsey-Seybold to divide the organization's Wi-Fi into internal and external networks, plus limit guest network bandwidth based on internal traffic loads. In addition, the security tool automatically and continuously moves BYOT devices from the guest network to the internal network, improving Kelsey-Seybold's security posture and reducing administrative costs.
"Our policy manager even enables us to quickly track down employee devices that may be infected with malware," Littmann says. "None of that was possible before."
According to Littmann, a network management platform is equally critical. "It's a tremendous asset for keeping an eye on our Wi-Fi environment." Littmann says. "We rely very heavily on its data collection and reporting capabilities to help us fine-tune the performance of our WLAN."
Real-time wayfinding on tap. At Kelsey-Seybold, the patient care benefits of a modern WLAN are palpable. This includes supporting Wi-Fi-enabled features available in the organization's Epic electronic health records system.
Littmann hopes to further enhance patient mobile experiences at Kelsey-Seybold by evaluating location-enabled technology for real-time wayfinding via a mobile app. "For instance," explains Littmann, "when a patient walks into our facility, he could receive a message that says 'Welcome, Mr. Smith, your 2:30 p.m. appointment with Dr. Miller is in Area A on our third floor. Also, if you need a prescription, our first-floor pharmacy is offering a discount today.'"
Kelsey-Seybold's WLAN now manages double the number of device connections it handled a year ago. And, with more people adopting IoT devices, such as personal fitness trackers, connectivity demands are only expected to rise.
"We're proud of our history of service and innovation," Littmann says. "We look forward to continuing to explore how Wi-Fi technologies can provide exciting new options to improve health care. With our new WLAN, we're ready."
As health care organizations continue looking for ways to control costs while improving patient experiences, reliable wireless infrastructure and mobile strategy are fundamental to supplying innovative, high-quality patient care in an environment where efficiency matters and seconds count.
Rick Reid, health care solutions product marketing manager, Aruba, a Hewlett Packard Enterprise Co.
Carolinas HealthCare launches first-ever mobile unit for lung cancer detection
The mobile CT unit brings care to underserved, at-risk residents in rural areas.
FDA clears first mobile diagnostic radiology application
March 2011 Checklist
First phase of new Eastern Maine Medical Center patient tower opens
New pavilion will modernize care for babies and includes space for families


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lights camera crohn's
an unobstructed view
Writing for a reason: IBD Pen Pals
Who says snail mail is a thing of the past? For one 10-year-old in the Chicagoland area, connecting with fellow IBD pediatric patients is helping her cope, comfort and help others as she takes on Crohn's disease herself. Meet Emily. This past February she received her chronic illness diagnosis. Even though she's brand new to IBD life, she's taking all the pain and all the setbacks in stride.
Her mom, Michelle, says watching her young daughter go through Crohn's has been a punch in the gut.
"It's overwhelming, lonely, and mentally draining for everyone involved. Her little body has been put through so much in the last few months and she just goes along with it all. I wish I could've done all the horrible tests and take away every ounce of her pain. My heart breaks every time she gets poked, every time she takes medicine, every time she has to do a test, or when I send her to school, knowing she feels horrible."
Emily's courage and compassion for others has inspired Michelle. Her Crohn's diagnosis has spurred an interest to connect with other IBD kids. Rather than take on the disease in silence, Emily finds there is strength in numbers, a purpose for her pain. Her mom was able to reach out to fellow parents on Facebook about a pen pal program.
"How cool to come home from school and have a couple letters waiting for you from kids all over the country?!? Emily has already made 12 new friends with IBD from the U.S. and the U.K. I never want Emily to feel alone on this journey nor do I want any other kids to feel alone. I want Emily to see that other kids who have IBD are living a "normal" life and that she can, too! There may be days when I won't understand what she's going through, but her new friends will."
From a parenting perspective, the pen pal group has introduced Michelle to other mamas going through the same fears and experiences. The connections have brought her peace of mind as she navigates these new waters with her daughter.
"Emily and I are firm believers in spreading positivity and what you give out, you get back. It's up to us to find the good in this situation and what better way than making new friends? Friends who understand and continually cheer you on, no matter how far they are. My hope is that Emily will make life long connections and that these letters will serve as a constant reminder that she is never alone."
Interested in joining this pediatric pen pal group? A Facebook page is in the works. In the meantime, you can get involved by emailing Emily's mom, Michelle: positivelyshelly@gmail.com.
Tagged: chronic illness, Crohn's disease, crohns, health, hope, IBD, IBD and children, IBD awareness, IBD pen pals, inspiration, invisible illness, making a difference, parenting with IBD, pediatric ibd, pen pals, snail mail, writing for a reason
Breastfeeding with IBD: 5 tips for getting started
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One thought on "Writing for a reason: IBD Pen Pals"
thepooponcrohnsdisease says:
This is marvelous! This young lady's mom and I connected when I started a blog for parents of Crohn's disease kids, called thepooponcrohnsdisease.com . Thank you for writing this. Anything that can give these kids hope for a normal-as-possible life is terrific. Thank you for writing this. See? Old-fashioned ways still have a niche in this world.
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Why Crohn's is the gift that keeps on giving


Most people need help in order to pay for their own. A student loan will help finance the cost of a college education.
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Don't eschew private student loans for college. There is quite a demand for public loans. Explore any options in your community.
TIP! Be sure you select the right payment plan option for you. The majority of student loans have ten year periods for loan repayment.
Don't panic if you get caught in a loan payment. Job losses or unanticipated expenses are part of life. There are options like forbearance and deferments available for such hardships.Just remember that interest is always growing, so try to at least make payments on the interest to keep the balances from increasing.
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You are here: Parliament home page > Parliamentary business > Publications and Records > Lords Publications > Annual Report
H O U S E of L O R D S
THE JUDICIAL WORK OF THE HOUSE OF LORDS
The House of Lords is the highest court in the land - the supreme court of appeal. It acts as the final court on points of law for the whole of the United Kingdom in civil cases and for England, Wales and Northern Ireland in criminal cases. Its decisions bind all courts below.
Conditions for Appeal to the House
The right to appeal to the House is ancient but the conditions under which an appeal can be made have become closely defined over the last 100 years. Each category of appeal is subject to statutory provisions which provide for the granting of leave to appeal and set out time limits within which leave to appeal may be sought from the House. In certain kinds of appeal the statutes require a certificate from the court from which the appeal is to be brought, e.g., civil appeals are governed by the Appellate Jurisdiction Act 1876 with additional provision for England and Wales in the Administration of Justice (Appeals) Act 1934.
Courts from Which the House of Lords Hears Appeals
The House hears appeals from:
The Court of Appeal (England and Wales and Northern Ireland) (civil and criminal appeals);
The Court of Session in Scotland (civil);
A Divisional Court of the Queen's Bench Division of the High Court in England and Wales and the High Court in Northern Ireland (criminal);
The Courts-Martial Appeals Court.
The House may also hear certain kinds of civil cases brought direct from the High Court in England and Wales and Northern Ireland under the "leapfrog procedure".
If the court below grants leave to appeal to the House of Lords the appeal may be presented direct to the House. If the court below refuses leave, a party may seek leave to appeal from the House itself. A petition for leave must be presented to the House within one month (fourteen days in criminal matters) from the making of the order of the lower court. Every admissible petition is referred to an Appeal Committee consisting of three Lords of Appeal. An Appeal Committee decides whether a petition should be refused or leave provisionally allowed. If provisionally allowed, objections will be invited from the Respondents to the petition (the other party involved in the case) and the Committee can then decide whether to refuse or grant leave or the petition can be referred for hearing and the decision made after both sides have put forward their arguments.
The Law Lords
The modern form of appeal to the House was established by the Appellate Jurisdiction Act 1876 when provision was made for the creation of Law Lords (the first life peerages). These peers, formally known as Lords of Appeal in Ordinary, also sit in the House like other members. They are required to have held high judicial office for at least 2 years or to have been practising as barristers for at least 15 years.
Today there may be up to 12 Lords of Appeal in Ordinary and they are usually appointed from the Lords Justices of Appeal, or less frequently, from judges of the High Court. Two are normally from the Scottish Bench. In addition, former Lords of Appeal in Ordinary, former Lord Chancellors and holders of other high judicial office are entitled to sit as Law Lords under the Act but in practice do so infrequently.
The Judicial Pensions and Retirements Act 1993, which came into force in 1995, lowered the age of retirement of Law Lords who had been appointed to high judicial office after the coming into force of the Act from 75 and 70. It also provided that no one except the Lord Chancellor may sit judicially in the House of Lords beyond the age of 75.
Sittings of the Court - When and Where
The Law Lords sit from Monday to Thursday throughout the law terms. The Law Lords may sit not only on days when Parliament is itself sitting for public business, but also during periods of parliamentary recess, prorogation and even (by special dispensation) during a dissolution. The House can be recalled specifically for judicial business.
The Law Lords used to sit daily in the Chamber of the House before public business began at 4.15 p.m. After bomb damage to the Chamber of the Commons during the Second World War changes were made. The Law Lords were moved "temporarily" to a Committee room to escape the noise of building repairs and were constituted into an Appellate Committee for this purpose.
This Committee first met on 26th May 1948. The experiment proved so successful that the arrangement continued after the repairs had been completed and in 1960 authority was given for a second Appellate Committee to be appointed. In modern times, although the Law Lords occasionally hear appeals sitting as the House, in the chamber, the majority of appeals are referred to, and heard by, Appellate Committees.
Hearing Appeals
For the purposes of hearing appeals an Appellate Committee usually consists of five Law Lords. Sittings take place in Committee Room 1 and, when necessary, Committee room 2. Final judgment on an appeal is always given in the Chamber, usually on a Thursday afternoon. This serves as a reminder that, despite modern practice, it is the High Court of Parliament that determines appeals.
Proceedings are less formal than the Courts below. The five Law Lords sit in a semi-circle round a horseshoe shaped table and the Senior Law Lord present presides as Chairman. They do not wear robes but counsel appear in wig and gown at the Bar across the centre of the room at which stands a lectern. Counsel for the Appellant(s) is heard first, then counsel for the Respondent(s) and finally counsel for the Appellant(s) in reply. There are frequent questions from the Law Lords as arguments are developed. The length of hearing varies but the average is just over two and a half days.
Once the hearing has been concluded the Law Lords discuss the case. Very occasionally they will recall counsel to tell them what the result of the appeal will be. Nevertheless, this intimation has no formal effect until it has been encapsulated in the Judgment of the House. By far the most usual arrangement is for judgment to take place a few weeks after the hearing, generally on Thursdays at 2 p.m. in the Chamber of the House. Sittings for judgments are full meetings of the House and other peers may attend although, by convention, only Law Lords take part in the proceedings. The Judicial Clerk summons counsel and other interested parties to the bar of the House and the presiding Law Lord sits on the woolsack as speaker.
Law Lords give their opinions in the form of speeches to the House. Each Law Lord states that for the reasons he has given in his prepared speech he would either allow or dismiss the appeal. The House, having agreed to the report of the Appellate Committee, then makes the orders which are the judgment of the House. The full speeches are made available to the public in printed form or via the internet.
After the House has given judgment a written order is prepared by the Judicial Office and signed by the Clerk of the Parliaments who is the Registrar of the Court. The Order is sent to the successful party.
Current list of Lords of Appeal in Ordinary and other Lords of Appeal (not disqualified by the Judicial Pension and Retirement Act) in order of judicial precedence.
Transcripts of judgments (Fees payable) are available from the Judicial Office.
Telephone: 0171-219 3111 Fax: 0171-219 2476
Since October 1996 this information has also been available on the Internet. Judgments are available by 4.30 p.m. on the day of the judgment at:
www.parliament.uk
S W 1 A 0 P W
Prepared 2 November 1998


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Arts & Life Arts & Entertainment The Arts
Drama an exploration of relationships
Fine performances power play set in historic Gettysburg
By: Randall King
Posted: 04/6/2019 4:00 AM	| Comments:
While it has discreet touches of haunting supernatural mystery, Annie Baker's drama John will doubtless scare off a few potential audience members due to its nearly three-hour length (including not one, but two intermissions).
Factor in that this is not a thrill-a-minute kind of piece. It proceeds at a leisurely pace, with quiet stretches that exceed the parameters of the Pinter pause.
Sometimes actors leave the stage altogether and take their dialogue elsewhere, leaving you to take in a painstakingly cluttered set depicting a bed-and-breakfast in historic Gettysburg, Pa. (Set designer Brian Perchaluk's set is a marvellous work of intricately detailed kitsch; imagine a Hallmark gift store in the throes of delirium tremens.)
But, to paraphrase Roger Ebert: no good play is too long and no bad play is too short. John is a good play, a sharply observed examination of relationships, fragile and otherwise, with spiritual elements pinging resonantly around its edges.
Into this tchotchke-laden B&B comes couple Jenny (Rosie Simon) and her longtime boyfriend Elias (David Reale), returning home to New York after visiting her parents in Ohio. Elias, a drummer/computer programmer by profession, is also a would-be historian, especially fascinated by the U.S. Civil War. He has brought Rosie, a professional question-writer for a game show, for a little holiday break in the home of Mertis ("Call me Kitty"), the owner of this aggressively charming house that once witnessed mind-blowing horrors when it had been pressed into service as a hospital in the aftermath of the Battle of Gettysburg in 1863.
Mertis (Maggie Nagle) is a conscientious hostess and she shows it by accommodating her troubled guests, even as they demonstrate that their relationship is in the middle of a feverish bad patch. Elias is weaning himself off depression meds. Jenny is suffering tortuous menstrual cramps and Mertis supplies curative chocolate-red velvet tea and also, later, wine, allowing Elias freedom to do on a midnight "ghost tour" of the battleground.
Revelations about the specific problems facing Elias and Jenny come courtesy of a visit by Mertis's blind best friend Genevieve (Terri Cherniack), who enjoys describing her battle with madness instigated by an ex-lover named John, whose voice dominated Genevieve's every thought during her long institutionalization.
Jenny's ears prick up at the name. She too has a John in her life, she says.
"Everyone knows a 'John,'" Genevieve deadpans, one of many of the play's universal truths.
It is Genevieve alone who claims to hear rustlings and voices in the house, but all the characters are touched by otherworldly things: Mertis, when she hears Jenny has slept in a different room, acknowledges that some rooms are safer than others when it comes to inexplicable phenomena. And Jenny, upon seeing a familiar doll, describes a childhood of torment, recalling her relationship with a doll she felt judged her.
Director Christopher Brauer grounds some of the play's more fantastic elements with grounded, naturalistic performances by the cast. Nagle is the show's anchor, a hard-working hostess who even takes it upon herself to open and close the curtain before and after each act.
Mertis has the potential to be played as a lovable loon, but Nagle affords her dignity and elder gravitas. Reale, last seen at the Royal MTC Warehouse in My Name Is Asher Lev, finds some empathy for a character who might easily be judged on his neurosis — hard-earned as it turns out. Simon, likewise, creates an admirably balanced performance: neither victim nor villain.
As the blind mystic Genevieve, Cherniack may have here one of her best roles, and she takes it on with great comic aplomb. Genevieve is the play's one character that is allowed to break through the play's restrained character dynamics. Cherniack takes that liberty and runs with it... joyously.
randall.king@freepress.mb.ca
Twitter: @FreepKing
In a way, Randall King was born into the entertainment beat.
By Annie Baker
Tom Hendry Warehouse
To April 20
Tickets $22-$41 at royalmtc.com
4 stars out of five


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MANILA, Philippines—President Benigno Aquino III is flying on Sunday to Brunei to attend the wedding of Sultan Hassanal Bolkiah's daughter.
Mr. Aquino, together with Foreign Secretary Albert del Rosario, will attend the wedding of Princess Hajah Hafizah Sururul Bolkiah this Sunday morning, Malacañang officials said Saturday night.
"Given that it is important to continue to strengthen our relations with fellow Asean (Association of Southeast Asian Nations) countries, the President will be engaging in some informal diplomacy," Undersecretary Abigail Valte, deputy presidential spokesperson, said in a text message to reporters.
The Sultan extended the invitation to Mr. Aquino and other heads of state on the sidelines of the Asia Pacific Economic Cooperation Leaders Summit in Vladivostok, Russia, early this month, said another official, who asked not to be named for lack of authority to speak on the matter.
Mr. Aquino, Del Rosario and a small group of security officers are expected to depart for Brunei on a chartered flight early Sunday, and fly back to Manila this afternoon, the official said.
Hajah, 32, the fifth child of the Sultan and Queen Saleha, and her groom, Pengiran Haji Muhammad Ruzaini, 29, exchanged vows last Thursday. They would be officially presented to the royal court SUnday to cap weeklong wedding festivities, according to reports.


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Wanna live the American dream? Live in the Midwest – at least that's what they say. But can this dream survive in a world where which Artificial Intelligence is not a novelty giving interviews on morning shows but rather integrated into the mundane and everyday?
Depicting primarily queer human and artificial characters and relationships, Bower Theatre Ensemble members Nathaniel Andrew, Elliot Sowards, Lizzy Sulkowski and Alexander Utz perform a series of linked absurdist sci-fi vignettes that ask us to consider whether the creators of A.I. – and by extension, technology at large – are more machine than their creation.


See the top Marine trips that go through France, Greece and Italy. With 5 tours to choose from, they range in length from 22 days to 31. The most popular month for these tours is June, which has the most departures.


Last Friday's homecoming hype was in full swing.
With every physical step taken by Perrysburg's 2018 attendants, there was a metaphorical step taken into our joy and excitement for the coming Homecoming Football game and the next night's GlowCo Homecoming Dance.
Homecoming King, Carl Conley, and Queen, Jesse Menke, led the court with pride in their school and their fellow students.
The crowd was a wave of red white and blue, whose energy flowed from the stands to the football field below where our homecoming court anxiously awaited. Those special students who walked the field, accompanied by their parents, knew that this was no superficial vote for tradition's sake.
Homecoming Court is often viewed as a popularity contest, but what it truly represents is those students who assert themselves as leaders in our school's community.
Homecoming Queen Jesse Menke supports this belief by describing her thought process on voting. She voted for people who "[she] knew were genuinely good people and not just people who [she] thought were popular and had to be on court.


As a hundreds of Mirena IUD lawsuits continue to move forward throughout the country, the U.S. District Judge presiding over the federal litigation has established a bellwether schedule that calls for the first trial to begin in March 2016.
Mirena is a long-lasting form of birth control known as an intrauterine device, or IUD, which is manufactured by Bayer Healthcare. The T-shaped device is designed to be implanted into the uterus to prevent pregnancy for up to five years. However, a growing number of women have suffered severe and debilitating injuries when the Mirena IUD migrated spontaneously, puncturing the uterus and causing other internal injuries.
Bayer currently faces more than 2,000 product liability lawsuits nationwide, all involving similar allegations that the manufacturer failed to provide adequate warnings about the risk of injuries associated with side effects of Mirena.
In the federal court system, about 600 of the cases have been centralized before U.S. District Judge Cathy Seibel in the Southern District of New York, as part of an MDL, or multidistrict litigation.
As part of the coordinated pretrial proceedings, Judge Seibel previously identified a small group of Mirena IUD cases to be prepared for early trial dates, known as "bellwether" trials.
According to a scheduling order (PDF) issued July 29, the first federal trial is expected to begin on March 7, 2016.
Judge Seibel outlined the process for completing discovery in the group of 12 bellwether trials, which will be narrowed down to six cases by May 2015. Following expert witness discovery and dispositive motions, the Court indicates that the first trial setting will be selected for that March trial date.
While the outcomes of this early trial date will not be binding on other plaintiffs, it is designed to help the parties gauge the strengths and weaknesses of their case and facilitate further negotiations to reach Mirena settlements to resolve the litigation without the need for thousands of individual trials.
Bayer introduced Mirena in 2000, aggressively promoting the IUD as a hassle-free form of birth control. However, a growing number of women and their doctors have reported problems where the Mirena IUD migrated from its initial implant location, perforating the uterus and other organs, causing infections and abscesses, and leaving women unknowingly unprotected against the chance of pregnancy.
Since 2000, more than 70,000 adverse events have been filed with the FDA involving Mirena IUD problems, including at least 5,000 cases involving women who indicated that Mirena moved out of place since 2008, and 1,322 reports where the Mirena IUD punctured the uterus.
Bayer has attempted to defend the cases, arguing that information about the risk of perforation was included on the warnings provided with the IUD. However, plaintiffs maintain that the previous warnings were vague and misleading, suggesting that the risk of injury only exists at the time of insertion. Most of the complaints involve women who found that the Mirena migrated spontaneously, often long after the IUD was successfully placed in the uterus.
In addition to cases filed at the federal level, nearly 1,000 cases have been filed in New Jersey state court, where similar consolidated proceedings have been established, centralizing all Mirena IUD lawsuits before Judge Brian R. Martinotti in Bergen County.
A similar bellwether process has been established in state court of New Jersey, which is where Bayer's U.S. headquarters are based. According to a prior case management order issued by Judge Martinotti, the first Mirena trial dates are not expected to be ready to begin until late 2015.
My daughter is in surgery right now to get it removed. It has moved and they couldn't find it until they did ultrasound so now she had to have surgery. I know she had severe stomach aches & cramping hopefully she'll be better after its out!
In 2014 my wife stroked due to Hypertension, while in hospital stroked a second time which set her recovery back during all this time the device was still implanted it was time for removable but no one thought to do so, she developed sepsis, after reading up own all symptoms, it my belief that the IUD, caused her death. fi a law firm is willing to look at med record and dates , contact me .


Back when she was scooping ice cream at a local joint called Thrifty's, Terri decided she wanted to study pre-med. As a young person, she also volunteered at animal shelters, veterinary clinics, and hospitals, gaining a lot of knowledge that would help her in her future.
Armenta loves science, chemistry, and what science can do. This naturally wired appeal, is what ultimately drew her to work in forensics.
What shifted Terri's interest from general science to forensic science started from an old crime-solving show called Columbo. With her dad, she watched the rumpled, slow-talking Columbo use details, facts, and scientific evidence to solve mysteries. Armenta didn't yet realize just what those evenings on the couch were sparking.
At first, Terri thought a medical career was the right choice for her, so she resolved to follow the long track that would lead to saving lives. But by pre-med, Terri was getting burned out with school, so she went to a job fair with her sister, where they were promoting a new Forensic Identification Program. She immediately and completely fell in love with it. Armenta wanted to dip her toes into this deeper world of investigation, so she took a leave of absence from her medical studies to take the classes for this new program.
1. She was on the wrong career path. Terri was more passionate about the study of death than interested in saving people.
2. She was completely hooked on this new thing called Forensic Science.
She knew she'd found her calling. Terri graduated, and four months later, the founder of that program contacted her.
Terri's start in what she calls, "the fun of forensic science," seemed at first like a detour, when in fact, it was the destination.
The Forensic Science Academy, Terri's current passion and focus, is a nationally accredited, six month, 200-hour hands-on training program, in Southern California. It was developed from another identification program that was handed over to Armenta around 2010, when its founder retired. Terri grabbed that career opportunity and built on it. She created online classes, while enhancing the on-site hands-on trainings.
Today, the Forensic Science Academy has six training modules offered on weekends over a six-month period. You can take the following trainings as part of a whole certification process, or individually, to educate yourself about specific skills, or reinforce them.
One of the things Arment prides herself on is cooperation and collaboration. The Forensic Science Academy works in conjunction with other courses, like those offered through the Death Investigator Training Academy, to educate, improve, and enhance the skills of those who investigate and crime-solve deaths.
I couldn't agree more. We're all part of the same team. In my work as a death investigator, both from the law enforcement and coroner perspectives I've found you may not be the one cordoning off an area, but you need to understand all aspects of what happens at a scene or in the lab by others.
I asked about student successes, from those who've completed the Forensic Science Academy course. Terri's excitement couldn't be contained.
Armenta, like myself, has an inner drive to train as many investigators as possible, in uniform methods. She's even had a student from Belgium sign up, who relocated to Southern California. More and more, inquiries are coming in from other countries, because of the need for field agents to receive consistent, reliable, and well-rounded teaching. The challenge for them is the six-month commitment.
The importance of teaching solid systems and predictable methods from a reputable source, is something most in the death investigative industry agree we need. The job of taking that training to different states and various regions, to meet the need for consistent and well-educated investigators, is not easy. But it is something Terri Armenta commits herself to daily. As a fellow advocate, I applaud her.
Forensic science mostly happens behind-the-scenes we work, but our findings impact the public in many ways. Families and friends of the deceased are affected. Court rulings are influenced. Careers are shaped. And we are defined, by how well we do the work we do. Facts are waiting on us to reveal them and people are counting on us to give them answers. For death investigators, we can't afford to get things wrong, proper training is how we get our conclusions right.


text:
Fermentative bacteria from estuarine mud: Phylogenetic position of Acidaminobacter hydrogenoformans and description of a new type of Gram-negative, propionigenic bacterium as Propionibacter pelophilus gen. nov., sp. nov.
Wim G. Meijer1,2, Manny E. Nienhuis-Kuiper1, Theo A. Hansen1
Affiliations: 1 Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, NL-9751 NN Haren, The Netherlands 2 Department of Industrial Microbiology, University College Dublin, Dublin 4, Ireland
Author for correspondence: Theo A. Hansen. Tel: +31 50 363 2163. Fax: +31 50 363 2154. e-mail: [email protected]
First Published: 01 July 1999 https://doi.org/10.1099/00207713-49-3-1039
The phylogenetic positions of two strains of fermentative bacteria that had been isolated from the highest positive tubes inoculated with serial dilutions of estuarine mud in agar media with either glutamate or aspartate as substrate were determined by comparative sequence analysis of their 16S rRNA genes. The strain isolated with glutamate (glu 65) utilized several substrates, including a number of amino acids but no sugars. The degradation of certain substrates was enhanced by or dependent upon co-cultivation with a hydrogen-utilizing partner. In earlier work this strain was assigned to the new genus and species Acidaminobacter hydrogenoformans. On the basis of its 16S rRNA gene sequence Acidaminobacter hydrogenoformans has now been identified as a member of cluster XI of the Clostridium subphylum with Clostridium halophilum as its closest relative. The aspartate-fermenting strain asp 66T was a Gram-negative, rather aerotolerant anaerobe which utilized a wide range of substrates in a propionic fermentation and had the ability to fix molecular nitrogen. Strain asp 66T was shown to be a new member of the ß-subclass of the Proteobacteria with Azoarcus sp. strain 6a3 and Rhodocyclus tenuis as its closest relatives. It is described as Propionibacter pelophilus gen nov., sp. nov., with the type strain asp 66T (= DSM 12018T).
Keyword(s): Acidaminobacter , Propionibacter gen. nov. and propionic fermentation
Copyright © 1999 International Union of Microbiological Societies
/content/journal/ijsem/10.1099/00207713-49-3-1039
http://instance.metastore.ingenta.com/content/journal/ijsem/10.1099/00207713-49-3-1039
10.1099/00207713-49-3-1039


Organiser Patina (parents and teachers in the arts) has announced that the annual event to mark outgoing year 6 pupils' transition to secondary school and into adolescence will have children's literature as its theme and the title Once upon a Moving On.
Director of the arts charity Caroline Croft said children's literature has been chosen as it is 'rich' for the imagination.
She said: "For a generation that is increasingly drawn to screens it will be great to celebrate books and storytelling.
Moving On, now in its 18th year, will take place on July 5, with pupils from 17 schools set to process wearing costumes and carrying carnival structures made with support from Patina artists.
Last year, 472 primary school pupils took part in Moving On; the title was Spread Your Wings and Fly and focused on human fascination with flight throughout history, such as in film, mythology and music.
See the video at the top of the page for photographs of last year's event captured by Peter Cripps.


text:
DP-PMI Day 2015 - Abstracts
The Physics of Impossible Machines
Vlatko Vedral (University of Oxford)
Maxwell's demon was born in 1867 and his sole function was to illustrate some potential problems with the Second Law of thermodynamics. He still thrives in modern physics and plays an important role in clarifying connections between thermodynamics and information theory. In my talk I will present a variety of different demons which, when restricted by the Second Law, will lead to interesting consequences in electromagnetism, optics, gravity, quantum mechanics as well as quantum information. Finally, I will speculate if the concept of information could in some sense be considered deeper than the entities typically though of as fundamental in physics and will mention various efforts to derive quantum physics from simpler information theoretic axioms.
Robustness of Spatial Quantum Search
Shantanav Chakraborty (PDEEC, IST)
A continuous-time analogue of Grover's algorithm can be formulated as a quantum walk on a complete graph of N vertices. We analyse the robustness of this algorithm against the loss of edges in the graph, as well as against static disorder. Firstly, when a few edges are removed from a complete graph, the dynamics of the algorithm is restricted to a three dimensional subspace and its optimality is retained. Subsequently, in the more general scenario where each edge of the graph remains with probability p, the underlying structure can be treated as an Erdos-Renyi random graph. We show that in the asymptotic limit, when N goes to infinity, search is optimal on almost all graphs as long as p = c N^(-z), where c is a constant and 0<=z<1. Secondly, we analyze the robustness of this algorithm to random static disorder in the diagonal and off-diagonal elements of the search Hamiltonian. We show that the algorithm retains its optimality as long as the standard deviation of the disorder is of O(N^(-1/2)).
Degradation of Entanglement between Two Accelerated Parties
Benedikt Richter (PDF, IST)
We study the entanglement of families of Unruh modes in the Bell states $|\Phi^\pm\rangle =1/\sqrt{2}(|00\rangle\pm|11\rangle)$ and $|\Psi^\pm\rangle=1/\sqrt{2}(|01\rangle\pm|10\rangle)$. Thereby we find fundamental differences in the robustness of entanglement against acceleration for these states. So are states $\Psi^\pm$ entangled for all finite accelerations, while, due to the Unruh effect, states $\Phi^\pm$ lose their free entanglement for finite accelerations. This is true for Bell states of two bosonic modes as well as for Bell states of a bosonic and a fermionic mode that are studied for the first time in this work. But also for Bell states of fermionic modes there are differences in the degradation of entanglement. We reveal the origin of these distinct characteristics of entanglement degradation and discuss the role that is played by particle statistics. Our studies suggest that the behavior of entanglement in accelerated frames heavily depends on the occupation patterns of the constituent states, whose superposition constitutes the entangled state, where especially states $\Phi^\pm$ and $\Psi^\pm$ inherit distinct characteristics regarding entanglement degradation. Finally, we point out possible implications of hovering over a black hole for these states.
Reflections on Quantum Data Hiding
Andreas Winter (Universitat Autònoma de Barcelona)
Quantum data hiding, originally invented as a limitation on local operations and classical communications (LOCC) in distinguishing globally orthogonal states, is actually a phenomenon arising generically in statistics whenever comparing a 'strong' set of measurements (i.e., decision rules) with a 'weak' one. The classical statistical analogue of this would be secret sharing, in which two perfectly distinguishable multi-partite hypotheses appear to be indistinguishable when accessing only a marginal. The quantum versions are richer in that for example LOCC allows for state tomography, so the states cannot be come perfectly indistinguishable but only nearly so, and hence the question is one of efficiency. The issues covered in the talk are going to be the following:
1. Every restriction on the allowed measurements, but with arbitrary processing of the measurement data at the end, gives rise to a norm on density matrices, the "distinguishability norm"; we will review the general theory of these [Matthews/Wehner/AW, CMP 291:813-843, 2009].
2. LOCC is perhaps the most natural restriction in multi-partite systems, and we will revisit LOCC data hiding and its efficiency.
3. Gaussian operations and classical computation (GOCC): Not very surprisingly, GOCC cannot distinguish optimally even two coherent states of a single mode [Takeoka & Sasaki, PRA 78:022320, 2008].
But we can find states, each a mixture of multi-mode coherent states, which are almost perfectly distinguishable by suitable measurements, by when restricted to GOCC, i.e. linear optics and postprocessing, the states appear almost identical. The construction is random and relies on coding arguments. Open questions include whether one can give a constructive version of the argument, and whether for instance even thermal states can be used, or how efficient the hiding is.
Mitigation of Power Side-Channel Leaks with Satisfiability Modulo Theories
Filipe Casal (PDInfoSec, IST)
Recently, the Automated Reasoning community has turned its attention to the area of Satisfiability Modulo Theories (SMT). In short, SMT deals with problems that are a generalization of boolean SAT problems, in the sense that we are dealing with first-order formulas and not just propositional formulas. On the other hand, the Security community has been very interested in the prevention and detection of side-channel attacks. Here, we will see how we can use SMT techniques in the mitigation of power side-channel leaks.
A Cold Atoms Experiment: Collective Behavior and Rydberg Physics
João Rodrigues (PDF, IST)
We present the developments in a Magneto Optical Trap (MOT) recently assembled by the Group of Quantum Plasmas - IPFN.
A distinct collective behavior is identified through a comparison between the experimental density profiles and the theory previously developed by the group. These collective processes are mediated by the multiple scattering of light, in conditions of high number of atoms and low laser detuning, which may lead to exotic phenomena such as photon bubbles, phonon lasing, classical rotons, twisted phonons, etc.
The current experimental efforts to excite high-lying Rydberg states are also discussed. We intend to investigate the Rydberg bloackade process, the building block of quantum information with neutral atoms.
Go back to the DP-PMI Day 2015 page.


And then I'm going to work my little hands to the bone for THE VIEW FROM HERE as the new kid on the block.
Oh and revising and writing and gosh...There's simply NO TIME to sit and eat BonBons this month.
The new year enters with masses of explosions here in Hawaii.
The next morning it kinda looked the same except for all the fireworks offal. Red paper. Cardboard. Passed out party goers in heaps.
In a few more days it was all cleaned up.
Except for the occasional wandering party goer with their head ornament slightly askew trying to find their hotel room and then realizing they actually live in Honolulu.
Sleep, eat, write and be happy.
...a novel about trust, loyalty, and what distinguishes us as capable..."
I consider myself a renaissance woman. I have been in the Army, worked as a medical technologist, competed as a professional horsewoman, been an educator, a diver,a sailor, a PHD student, writer and now an author.
KUDOS FOR LOTTERY CAN BE SEEN HERE.
AUTHOR EVENTS CAN BE SEEN HERE.
Orion is a 48-ft Celestial Ketch. She was abandoned in the middle of the Pacific Ocean during a storm and over the course of several months found her way back to the Big Island. When my husband and I first looked at her and found out her history we decided she was the boat for us and bought her. She sails like a dream and we love her dearly.
For luck, success, and good fortune.
The first contract that came was from the Netherlands.
IT GOT HERE SAFE AND SOUND - The real honest to goodness hardback.
Is that a margarita in your hand or are you just glad to see me?