Cambridge, Mass., April 3, 2018 — H3 Biomedicine Inc., a clinical stage biopharmaceutical company specializing in the discovery and development of next-generation cancer medicines using its data science and precision chemistry product engine, announced today the publication of a comprehensive genomic landscape analysis illuminating the breadth, frequency and potential disease-driving significance of somatic mutations in RNA splicing factor genes in human cancers. The findings demonstrate that splicing factor mutations, which lead to RNA splicing dysregulation, are highly prevalent in many hematologic and solid tumor cancers, suggestive of their role as a hallmark of tumor formation and growth and, thus, opportunities for therapeutic intervention. RNA splicing is the biological process by which pre-cursor messenger RNA (pre-mRNA) is edited into a mature messenger RNA (mRNA). Splicing factors carry out the editing process which is catalyzed by the core spliceosome complex. H3 Biomedicine scientists' research and findings were published in the most recent online version of Cell Reports. (Seiler M. et al, "Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types"). This manuscript is part of The Cancer Genome Atlas (TCGA) Program, a joint effort of the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI).
Using whole exome and RNA sequencing data in TCGA, H3 data scientists analyzed over 10,000 patient samples across 33 tumor types to identify somatic mutations in RNA splicing factors. The analysis of over 400 splicing factor genes identified 119 genes as having putative driver mutations, including over-representation, recurrent loss-of-function or recurrent hotspot (oncogene-like) mutations.
Mutations in splicing factor genes were found in all 33 tumor types with the frequency of mutations in multiple splicing factor genes as high as 60% in patient samples of the same tumor types, representing a much larger occurrence than previously reported. In addition, H3 scientists, as exemplified in case studies of five genes, showed that mutations in splicing factor genes led to dysregulated or altered splicing in mutated cells.
H3 Biomedicine is advancing novel cancer therapies that target core splicing factor mutations. A Phase 1 trial is underway in patients with hematologic malignancies for the company's first spliceosome pathway-targeting cancer therapeutic, H3B-8800, a potent, selective and orally bioavailable small molecule modulator of wild-type and mutant SF3b complex, a splicing factor gene. The study is evaluating the safety and preliminary efficacy of H3B-8800 in patients with myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia who carry mutations in splicing factor genes. Preclinical data demonstrate that H3B-8800 modulates RNA splicing and shows preferential antitumor activity in a range of spliceosome-mutant cancer models.
H3B-6527, an oral, potent and highly selective small molecule covalent inhibitor of FGFR4 for treatment of hepatocellular carcinoma (HCC) patients with overexpression of FGF19.
H3 Biomedicine, a Cambridge, Massachusetts-based biopharmaceutical company specializing in the discovery and development of precision oncology treatments, was established in 2011 as a subsidiary of Eisai's U.S. pharmaceutical operation, Eisai Inc. H3 Biomedicine combines long-term vision with operational excellence, leveraging its collaboration with Eisai Co., Ltd., who provides essential research funding and access to the capabilities and resources of a global pharmaceutical company. Using modern synthetic chemistry, chemical biology and human genetics, H3 Biomedicine seeks to bring the next generation of genomics-based cancer treatments to market with the goal of improving the lives of patients. For more information, please visit www.h3biomedicine.com.


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Q: Python iterating over a dictionary for some reason I just can't iterate over a dictionary in Python. I've done it before but somehow I can't make it happen anymore. I feel like I'm missing something obvious although I don't know what exactly. I am currently learning Python at http://learnpythonthehardway.com/book Exercise 48. Using Nosetests and a given testcode I should then code the according code in the actual script to make the test work. Here is the code in the testfile:
from nose.tools import *
from ex48 import lexicon

def test_directions():
    assert_equal(lexicon.scan("north"), [('direction', 'north')])
    result = lexicon.scan("north south east")
    assert_equal(result, [('direction', 'north'),
                          ('direction', 'south'),
                          ('direction', 'east')])

So now I wrote this code to make the test work:
lex = { 'dir':'north', 'dir':'south', 'dir':'east', 'dir':'west',
        'dir':'down', 'dir':'up', 'dir':'left', 'dir':'right',
        'verb':'go', 'verb':'stop', 'verb':'kill', 'verb':'eat',
        'stop':'the', 'stop':'in', 'stop':'of', 'stop':'from', 'stop':'at', 'stop':'it',
        'noun':'door', 'noun':'bear', 'noun':'princess', 'noun':'cabinet'}

def scan(word):
    for k in lex:
        if lex[k] == word:
            return (k, word)
    return None

assert_equal() just checks if both parameters are the same.
I am pretty sure this should work but anyway I changed it according to the Python documentation:
def scan(word):
    for k, v in dict.iteritems():
    if v == word:
        return (k, word)
    return None

Both ways just throw a None back at me and I just can't figure out why.

A: The way you build your lex dictionary is wrong. For example, you start by storing north for the key dir. Then you overwrite the key dir with south, and so on.
In the end, only one of those values is stored for dir. If you want multiple values in one key, combine them in a tuple:
"dir" : ("north", "south", "east", "west")
you'll need to adapt your other code to this change too, then, though.

A: Something like the following would work, a list of acceptable words for each dictionary key is used:
lex = { 'dir': ['north', 'south', 'east', 'west', 'down', 'up', 'left', 'right'],
        'verb': ['go', 'stop', 'kill', 'eat'],
        'stop': ['the', 'in', 'of', 'from', 'at', 'it'],
        'noun': ['door', 'bear', 'princess', 'cabinet']}

def scan(word):
    for k, v in lex.items():
        if word.lower() in v:
            return (k, word)
    return None

print scan('north')

Which would print:
('dir', 'north')

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— Radical Shi'ite cleric Sheik Muqtada al-Sadr, threatening suicide bomb attacks on US troops, Associated Press, April 24.
— William J. Perry, US Secretary of Defense from 1994 to 1997, Moscow Times, May 7.
—Dominique Moisi, French Institute for International Relations, about US Secretary of State Colin Powell, Wall Street Journal, April 30.
—Australian foreign minister Alexander Downer, signed column, Wall Street Journal, April 27.
— Rumsfeld at "Town Hall Meeting" with US troops in Iraq, May 13.
— Konstantin Kosachyov, chairman of Duma International Affairs Committee, Moscow Times, April 23.
— Deputy Secretary of Defense Paul D. Wolfowitz, on number of US troops killed in Iraq, House Appropriations Subcommittee on Foreign Operations, April 29. Actual numbers at that point: 726 dead, of which 524 were combat deaths.
—Former Sen. Robert Dole on the new World War II Memorial in Washington, D.C., CBS News, May 27.
—Libyan leader Muammar Qaddafi, who is known in his country as "Brother Guide," New York Times, April 28.


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text:
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Public Sector Solutions Review
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By Kevin Seller
The Public Sector Solutions Expo was held at the ExCel London and, for the first time, was held over two days. This presented an excellent opportunity for decision-makers and influencers to pre-engage with a wide range of suppliers, with over 100 expert suppliers, 2,500 public sector professionals, and 140 speakers in attendance. Government Digital Services (GDS) and Crown Commercial Services were also prominent in the exhibition area.
There were five dedicated theatres, Commissioning and Procurement, Digital and Technology, Public Finance, Workforce and Leadership, and Assets and Estate Management. Each hosted a series of thought provoking presentations and panel discussions throughout the two days. In addition, GDS hosted a small presentation hub on their stand, where they delivered presentations and hosted Q&A drop-in sessions.
One of the highlights of day one was a panel session in the Digital and Technology Theatre, hosted by Henry Rex, Head of Public Sector at TechUK. The panel focused on bridging the public sector digital skills gap to support long term digital transformation. One particularly interesting area discussed by the panel – which consisted of Simon Leeming from DCMS, Paul Schagen of the GDS Academy, and Debbie Brown of Salford City Council – was how do we equip people with relevant skills in a fast-moving digital world. It was particularly interesting to hear Simon Leeming say that the degree with the highest rate of graduates still unemployed six months after graduating was Computer Science, because skills learnt two or three years ago are already out of date. It's key that graduates continue to learn even once the syllabus is finished to ensure their skillsets remain relevant.
On day two, the Digital and Technology Theatre played host to a panel discussion chaired by Sue Bateman of GDS, looking at innovation in government. She was joined by Sebastian Krier, who spoke about the role of Artificial Intelligence across government, and Ian Tester, who spoke about the GovTech Catalyst. Ian explained how they select challenges to put to a range of suppliers, with 5 shortlisted suppliers being given £50k each to develop a solution. The two best solutions then receive further funding to produce a production-ready solution.
The Commissioning and Procurement Theatre opened day two with a keynote from Simon Tse, Chief Executive of Crown Commercial Services (CCS). Simon gave a very open and frank assessment of CCS. He accepted that there was still work to do, but also explained the impact they'd already had on saving money, and was particularly proud of activity in key areas – such as Education and Health – where the savings delivered were being re-invested in improving services. He also talked about the future of CCS, how they want to have a more dynamic procurement system that can see suppliers added and removed during the life of a framework. Simon also explained that he is keen to see government carry out a lot more pre-market engagement, with suppliers helping inform buying decisions.
The Public Sector Solutions Expo certainly delivered, and it's encouraging to see more engagement between buyers and suppliers being openly sought by CCS.
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Q: SQL Server 2017 cannot connect to remote databases I tried to uninstall some old versions of SQL Server I had installed just to free up hard drive space, and along the way I corrupted my SQL Server 2017 such that SSMS could no longer connect to any remote databases. After a lot of troubleshooting, I gave up and decided to reinstall SQL Server and SSMS. I uninstalled SQL Server and related software and reinstalled it, but I still have the same problem as before of not being able to connect to remote databases.

*

*I'm using Windows 10 Home

*I can connect to my local database using SSMS for what it's worth

*I can connect to the remote database from other computers

Here is the "Cannot connect" error:

Here is what I get when I search SQL in Add/Remove Programs

How do I get to where I can connect to remote databases again?


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Book review: Fifteen Words by Monike Jephcott Thomas
December 2, 2016 December 2, 2016 ~ Debra Schoenberger
Publisher: Clink Street Publishing
Published: (November 22, 2016)
Two young doctors form a profound and loving bond in Nazi Germany; a bond that will stretch them to the very limits of human endurance. Catholic Max – whose religious and moral beliefs are in conflict, has been conscripted to join the war effort as a medic, despite his hatred of Hitler's regime. His beloved Erika, a privileged young woman, is herself a product of the Hitler Youth. In spite of their stark differences, Max and Erika defy convention and marry.
But when Max is stationed at the fortress city of Breslau, their worst nightmares are realized; his hospital is bombed, he is captured by the Soviet Army and taken to a POW camp in Siberia. Max experiences untold horrors, his one comfort the letters he is allowed to send home: messages that can only contain Fifteen Words. Back in Germany, Erika is struggling to survive and protect their young daughter, finding comfort in the arms of a local carpenter. Worlds apart and with only sparse words for comfort, will they ever find their way back to one another, and will Germany ever find peace?
Fifteen Words is a vivid and intimate portrayal of human love and perseverance, one which illuminates the German experience of the war, which has often been overshadowed by history.
Buy the book: Amazon UK
About Monike Jephcott Thomas
Monika Jephcott Thomas grew up in Dortmund Mengede, north-west Germany. She moved to the UK in 1966, enjoying a thirty year career in education before retraining as a therapist. Along with her partner Jeff she established the Academy of Play & Child Psychotherapy in order to support the twenty per cent of children who have emotional, behavioural, social and mental health problems by using play and the creative Arts. A founder member of Play Therapy UK, Jephcott Thomas was elected President of Play Therapy International in 2002.
A riveting and raw account of life during WWII when Germany was on the verge of losing the war. We see how, despite coming from very different backgrounds, Erika and Max choose to make a life together. Both are doctors.
While Erika remains behind, Max goes is conscripted to work for the Nazis as a doctor. He detests Nazi ideology but is determined to help as many of the wounded as he can. A timid man by nature, an early boyhood experience helping his aunt rescue the wounded as a result of a bomb blast targeting civilians gives him the courage to put his life at risk to save others. He is aware that, if he survives the war, he will always carry the emotional scars of the war with him.
Intense, nail-biting and thought-provoking, this novel reveals what every-day Germans who did not agree with Hitler felt as the war raged on.
The author's writing style is unique, lyrical and poetic. It helps temper the rawness of the atrocities perpetrated by so many of those who, due to abuse of power, rendered the lives of so many to sheer misery.
For both Erika and Max, fifteen words of dialogue continue to link them together. But they may not be enough.
Posted in #redhead.with.book, Book review	#redhead.with.bookAuthorightBook ReviewFifteen Wordshistorical fictionMonike Jephcott Thomas
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I do wonder how much more we'll end up paying as a result. This would be a great idea if Canadian ISPs and TV service providers — which are the same thing these days — didn't treat their customers so poorly.
We have two major providers in Calgary: Telus and Shaw. There are smaller companies, too, but they largely resell the same Telus and Shaw pipes. Telus has traditionally been more expensive than Shaw, and it became a local waiting game of seeing which company would budge first. Unfortunately, it was Shaw — I'm with Shaw — who raised their prices across the board. My package's price increased by 50%, which is atrocious. These prices took effect just prior to a few laws which affected major ISPs.
My cell plan, on the other hand, is with Telus. In December, new laws are going into effect which will prohibit the three-year contracts all Canadian wireless companies default to. As such, new two-year plans are being rolled out across the board which increase the already-exorbitant monthly fees we pay.


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Home » First Class Travel Blog » Uh Oh: Norwegian Canceling Long-Haul Scandinavian Routes
Uh Oh: Norwegian Canceling Long-Haul Scandinavian Routes
Posted By Stephen Hoechst on Nov 27, 2019 | 1 comment
Norwegian Air has been going through difficult financial times. After a failed takeover attempt by IAG, many wondered whether Norwegian would be next. Given all the European low cost carriers that have liquidated lately, it's almost been a surprise that Norwegian hasn't joined them.
However, things have seemed to be moving in the right direction as of late. The airline reported a record profit last quarter and recently hired a new CEO. Whether the airline remains on track to sustainable profitability is yet to be seen.
Norwegian Canceling Long-Haul Service
Norwegian Boeing 787-9 (image courtesy of Wikimedia Commons)
Effective March 29, 2020, Norwegian will end long-haul operations from Stockholm and Copenhagen to the US. In addition, the airline will also end operations between those cities and Thailand. They'll also be ending the Oslo-Bangkok route this summer. However, the airline plans to continue long-haul flights between Oslo and the US.
The airline said their Stockholm and Copenhagen long-haul routes were losing money due to low demand and issues with their Boeing 787s. With new leadership and a renewed focus on profitability, the airline was looking to reduce losses. It seems like these routes were a part of the problem and not worth the trouble.
Courtesy of Travel with Grant
You're probably wondering, "OK, so what? It's just a couple routes to the US that I'd probably never fly anyway." While that may be true, this still has the potential to impact just about every flyer.
Norwegian may not be your ideal way to get across the Atlantic, but they serve a very important purpose in the Transatlantic market. By offering low fares, Norwegian has forced competitors to bring down their prices. They're largely the reason why we've seen record low airfares across the Atlantic. With WOW Air already going under, Norwegian is the last major low cost carrier operating in the market. If they were to fail, it's likely that these fares would rise and in a hurry.
While Norwegian is reducing transatlantic service from their non-Oslo locations, they currently do not have plans to reduce service from Oslo. In addition, they apparently plan to add long-haul flights between the US other popular European markets, such as London, Barcelona, and Paris.
The airline also stated that there are no planned changes to their intra-European short-haul service at this time.
Obviously, it stinks anytime an airline has to cancel routes. It gives travelers one less option to get from Point A to Point B. However, in this case, I think it makes sense. Norwegian has been struggling with profitability and these routes appear. This isn't a huge pull-back. It's just a few long-haul routes.
If it helps Norwegian on the route to profitability, I'm all for it. The transatlantic market needs a low cost competitor to keep prices low on airlines like Delta, American, and United. Let's hope this is a smart financial decision rather than a sign of trouble ahead.
What are your thoughts on Norwegian canceling these long-haul routes? Is it a smart business move or a worrying sign of things to come?
Author: Stephen Hoechst
JeffieBoy
Having flown the short lived YYM-DUB route this summer, I was saddened to see the almost immediate cancelation of the route and now all these others as well. I feel this will be a problem in the future as it will give carte blanche to the other Canadian air pirates to steal our wallets. Wow and Norwegian held them to accounts. Sorry to see them go, hope they return! They will have my business.


Jordan's heart felt lyrics, catchy choruses and sultry voice are a staple of her music and are the driving force behind her debut album The Lonely Hearts Club which was released June 2016. Jordan obviously has a huge passion for music and songwriting and is excited to share it. It's a winning combination, Take Me Out Tonight is ultra catchy with lots of hooks throughout. With the sing-a-long chorus and beautiful melody, it stands out. Her voice is unique, but in the best possible way. It's melodic dance music with just enough production bite to keep things fresh and interesting. Jordan has such a wonderful and natural voice that just keeps getting better, It's so upbeat and makes you feel euphoric. If you're into songs with feeling and a varied pace and tempo then this is the artist for you.
The song has a relaxed, poppy sound but manages to avoid sounding over-manufactured and too similar to the other music that is around today. I'm serious, she is one of the most innovative artists I've ever heard. It's so refreshing to hear some genuine talent and originality. This record is a true gem that shines way brighter than any of the clichéd tunes that have choked the airwaves over the last few years. I hope that her musical career continues to flourish. Personally, I'm already looking forward to her next album, she'll be massive in 2017, deservedly so!
I'm not the only one writing positively about Jordan Alexander, there's acknowledgement all over from Media, Internet and Artist's alike. She's currently being referred to as the 'Next Gay Pop Star' – AfterEllen, and picked by DIVAMag.co.uk as 'Queer Ones To Watch in 2016', It's no wonder really that Bif Naked has personally chosen Jordan to appear on the Bif Naked – I,Bificus – Songs and Stories Tour.
If you enjoy this track as much as I do, then I think you'll love Jordan's newest album 'Lonely Hearts Club' – It's available on Apple Music. You can also keep up to date with their latest offerings by following them on Twitter, Instagram & Facebook.
I've been a fan of Chanel N°5 for as long as I can remember, it's my go to comforting fragrance.


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Equipping You For Success With Social Media
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I'm Andrew Knowles, welcome to my business blog. Here you can find tips, tricks and ideas to make the most of digital marketing and social media for your business.
I post regular tutorials and guides to help you get started, as well as more in-depth articles on topics such as SEO, local Dorset businesses and measuring website traffic.
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Posts in Dorset business
Dorset foodie uses social media to spice up her business
IIlana Smith of Hari Hari is an inspiration to anyone who wants to set up a small business based around food. She's combined her passion for cooking with her Sri Lankan roots to create a brand that's getting noticed, and, of course, she's using social media to get the word out. I recently spoke with Illana to learn more about the origins of Hari Hari and the part that Twitter, Facebook and Instagram have played in her story so far.
Dorset foodie
The seeds of a spice shop
Illana's professional background is HR and training in bigger companies. Like so many of us, she wanted to work for herself, which meant looking at the resources and opportunities available.
Being half-Sri Lankan, and having lived there for many years, she had a deep appreciation for Sri Lankan curries, which she loves to cook. The difference in taste means she prefers to use spices shipped directly from Sri Lanka, rather than those bought in the UK.
Turning these spices into meal-ready packages seemed to be a great way for Illana to combine her curry passion with her business ambitions.
She spent a year planning the business. Advice she received early on was to set a high standard of presentation from the start, making it important that her branding and packaging was right from day one.
Dorset foodie cooking
Growing a business through networking
Hari Hari began in 2014 with a website and a Facebook Page. Illana then discovered and joined The Anonymous Travelling Market, which promotes local food and craft in the South West. That led her to Dorset Food & Drink, where she made the most of every networking opportunity on offer, picking up loads of advice from fellow producers at every event.
One of the most useful revelations was the power of Twitter to connect small businesses. Through Twitter, Illana has made lots of useful new contacts with other small producers and local retailers.
Because retailers have seen Hari Hari being talked about on Twitter, they're more open to putting the spice packages on their shelves. Whereas some shops were initially wary, some are now approaching Illana in order to stock her products.
Another revelation to Illana was supper clubs, where foodies gather around a table to share a meal and get to know one another better. She has gone on to develop a supper club in conjunction with Comins Tea House in Sturminster Newton.
Hari Hari food
How people and social media have helped Hari Hari
Illana effectively launched her business at the school gate, supported by a website and Facebook Page. Today that Page has well over 400 likes. She also has over 800 followers on Twitter and over 1,100 followers on Instagram.
As a sole trader, Illana struggles to give more time to social media. She's also very happy with the follower numbers because, while they're not high, they deliver results.
Illana's approach to Facebook and Instagram is to share the journey that she's on, while Twitter is more about connecting with other businesses. She usually posts at least one Instagram picture per day, and posts on Facebook two or three times a week. Because they're important channels, she keeps up with them during the day.
If you're thinking of setting up a business, or already run one, here are some tips from Illana:
Give social media time - it takes one or two years to really start getting results.
Be patient about sales - it took around a year for her website sales to go from zero to frequent.
Have a way to measure success - for Illana this is repeat customers. A very high percentage of those who buy from her come back for more.
Dorset is well known for its specialist, artisan food producers. Hari Hari is a part of that vibrant community, both online and offline. It's a great example of how someone is making a success of their business ambitions by connecting with their passion and harnessing the power of social media.
Hari Hari is a 2016 Taste of the West gold award winner.
Click here to learn more about Hari Hari spices.
Hari Hari packs
Business networking, Dorset business, MarketingAndrew Knowles 8 November 2016 Dorset, social media, small business, marketing, Hari HariComment
How a Dorset author uses social media to sell books
If you want to know how to promote your product through Twitter, you can probably learn something from Di Castle of Swanage. In 18 months, she's sold hundreds of copies of her 'Grandma's Poetry Book'. That's some achievement, particularly for a volume of poetry, and she's confident there's potential to sell a lot more. Di kindly agreed to share with you the story of how Twitter helped her find and then grow her market. Whatever you sell, or promote, through social media, there's something to learn from her experience.
Of course, not all of Di's sales come as a result of using Twitter and other social media channels. She sells at fetes and fairs, and even sold from a Swanage beach hut in the run up to Christmas.
But Twitter has helped her sell further afield and, perhaps more significantly, build a network of valuable contacts.
Find the right publisher for the book
Having written for years, when Di became a grandmother she pulled her poems into a collection and began looking for a publisher. People were genuinely complimentary about her work, but poetry books don't get a lot of space on retailers' shelves.
Grandma's Poetry Book cover
She found an illustrator, Denise Horn, also from Swanage, and at the Winchester Writers' Festival she connected with self-publishing specialists Matador.
When she signed up, Di agreed to pay Matador to promote her book on social media. But the publisher then spotted she already had a presence on Twitter and suggested that rather than pay them, she could take on the book's promotion on social media.
Di then took the sensible step of getting some training. She attended some courses, including a workshop I ran with my wife, Rachel, at Purbeck Literary Festival in 2015.
Grasping the power of the hashtag
Di is very clear about what she learned from her training. This included:
The importance of having good quality content on your blog or website
Not being afraid to tweet links to your content more than once
Why and how to schedule tweets
The power of the hashtag
Like so many people, Di didn't really understand how a hashtag worked. When it was explained, and she was encouraged to engage with hashtags popular with authors, such as #amwriting and #amreading, she found her tweets began to get attention.
Di started becoming strategic about who she followed on Twitter. Previously it had been a very mixed bag, so she unfollowed many of them and became more focused on following bloggers, particularly parent bloggers. She discovered them through the #mblogger and #pblogger hashtags (that's mum bloggers and parent bloggers).
Di engaged with the bloggers, retweeting them and starting to build relationships. Then she asked if they'd like to review her book, which several did. The bloggers then shared links to the reviews with their audience.
Finding and focusing on the target audience
By now, Di knew that the people most likely to appreciate her book were grandparents. They'd either buy it for themselves or people would buy it for them as a gift.
Di Castle
Through Twitter she discovered Gransnet, an online community of grandparents, who reviewed her book. Then she tweeted to Saga, who agreed to run a competition for a signed copy of her book. The exposure she received brought in hundreds of new followers.
All the time, more and more people were getting to hear about 'Grandma's Poetry Book' and many were buying. Perhaps more satisfying, for a writer, was the positive feedback about the book. Social media makes it really easy for authors, and anyone else with a 'product', to hear what people think of it.
One important lesson for Di has been that someone she's sold to once often becomes a repeat customer. Because the book makes an ideal gift for a new grandparent, people come back for more copies for friends and family. This gives her confidence that the book will keep selling.
She is continuing for look for outlets frequented by her target readership. She's approached the National Trust and the book should soon be appearing on the shelves of their gift shops.
The unexpected benefit of social media engagement
Through Twitter, Di has developed a strong network of contacts. Some of them have asked her to write for them, giving further opportunities to grow her profile in the online communities of which she's become a part.
She's even written about her experience of getting to grips with Twitter on the popular women's website, Henpicked.
Today Di spends about half an hour a day on social media, covering both Twitter and Facebook. She's now much more confident about using social networking to promote what she doea, although she admits that, like the rest of us, there's still plenty to learn.
Click here to learn more about Di Castle and her 'Grandma's Poetry Book'.
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Dorset businessAndrew Knowles 22 April 2016 Comment
How to get a great headshot photo
First impressions count for a lot. However much we might say that we want to judge by merit, not appearance, our initial opinion is heavily influenced by how someone or something looks.Whether we're researching a restaurant or shop, a new business contact or potential employee, a website or social media profile, our reaction will be affected by those first impressions.
This is why the quality and presentation of the headshot photos you use on social media are so important. I recently picked up some useful tips from photographer David Morphew which I'm sharing here.
We humans are a social lot and we're naturally drawn towards pictures of people. Hence the recommendation to use a headshot or portrait photo on your social media profile. We find it easier to connect with people than with a logo or some other, more impersonal image.
A headshot photo brings the added benefit that people recognise you when you meet in person.
As portrait photographer David Morphew was updating the images I'll be using on my social media accounts, we chatted through the elements that make up a great headshot.
Use a professional photographer
This is my tip, not David's. A good quality portrait says a lot about your attention to detail and the best way to get one is by using a professional. Or at least a good amateur.
During my training courses, when I talk about using portrait or headshot photos, quite a few people tell me they don't like photos of themselves. In most cases, I suspect that's because they've not been photographed professionally.
And even if you really don't like to see a picture of yourself, you're not putting an image on your social media profile for your pleasure. You're doing it as part of your online marketing.
People do business with people, not logos, so I recommend you start that person-to-person relationship as early as possible. Photos of yourself that you're not embarrassed to use are a great asset.
Relax and enjoy the shoot
I find it hard to smile for the camera. That's because I don't usually pay much attention to how I smile - it just happens. When David asked me to smile, I became aware of all those facial muscles that normally work unconsciously.
Part of the photographer's skill is to get the subject to relax and to forget those facial muscles. David's jokey, slightly irreverent style made that easy. He coaxed me into a variety of facial expressions without me needing to try too hard.
I have a newfound respect for professional models who know how to manipulate their look!
Changing the the environment can help you relax. Below are two photos that I like - one is posed and the other David snapped when we went for coffee after the shoot. I thought we were done when we got to the cafe, but clearly not.
Think about the look you want to achieve
David recommends that you wear your normal business attire for a photoshoot, and ideally have some variations on it.
You'll look most comfortable when you're wearing clothes that you're used to. It also helps people connect with you more easily, both through a photo and if you meet in person.
Variations in appearance can help you transition between the serious professional look and the more relaxed, approachable style. Both may deserve a place in your portfolio, depending on the context in which the photos are to be used.
You may want to use a more relaxed, smiling image on Twitter, but adopt a more formal look for LinkedIn. If you're using the photos to go out with press releases, you want an image that matches the tone of the story.
Lighting makes a huge difference
David talked about sculpting with light. From the way he speaks, you know that he's continually thinking about how to use lighting, both natural and artificial, to get a better result.
The easiest way to discover what approach to lighting works best is to try several alternatives. David shot me in his studio using natural light, then with a seriously large but not overwhelmingly bright flash. After that, we went outdoors into a chilly, bright February morning.
While we liked the idea of the outdoors photos, they didn't make it to the final portfolio.
Andrew Knowles
Don't face the camera directly
Why do passport photos look so grim? Because you're staring directly into the camera lens, with no smile, and the lighting is purely functional.
David's advice for getting a decent headshot is to position your shoulders at an angle to the camera. Take a look at the photos below - one is square on, the other at an angle.
The camera itself doesn't need to be at the same height as your face. It could be looking down on you, or looking up. Looking down is popular because when you look up to the camera, the skin beneath your chin is stretched, helping to mask sags and bags.
It's not obvious from these photos, but when David took them, I was sitting down and he was standing up.
Perfecting the results with image editing
Many of my photos looked great straight out of the camera. David's skill with lighting, angles and depth of field was evident. But there was still room for improvement using Photoshop.
David hasn't performed virtual plastic surgery on me, trimming off pounds or reshaping my nose and chin. All that was possible, I'm sure, but it wasn't what I wanted.
Now it's time to play 'spot the difference'. Before reading on, take a look at the two photos below to see what's changed.
How many differences did you count? I've not asked David what he altered, but there are at least three changes.
First, it's brighter, bringing out more of the colour in my face and clothes, and brightening the background.
Secondly, I've been flattered by having the lines around my eyes softened. They're not hidden - just not quite so obvious.
Thirdly, my hair is a little more under control. I confess this is a change I made having received the photos. My hair does have a tendency to stick out at odd angles, despite my best efforts to take control of it. In this case, that control came through Photoshop.
When I put the two images side by side on my computer screen, I also thought that David had airbrushed out a mark on my face, but then I realised it was a mark on my screen!
How often should you update your headshot photos?
The photos I've been using until recently were taken in 2008. That's eight years ago. I leave it for you to judge whether I needed to update them.
I recommend that you consider updating your headshots every two to three years. Your appearance may not have changed much, but perhaps the image you want to portray has.
Putting fresh photos of yourself on your website and social profiles gives them something of a refresh.
Don't be shy when it comes to using headshots as part of your marketing. Be confident that your face is an asset. Using good quality headshots means you're taking control of how your face appears, in order to help make that all-important positive first impression.
Click here to learn more about photographer David Morphew, who's now based in Dorset.
How to use a hashtag
How to start using Google Analytics
Dorset business, Guides, OpinionAndrew Knowles 9 March 2016 Comment
Business networking for pleasure and profit
Business networking can be scary. I remember the nerves the first time I walked into a room full of strangers at a networking event. For some, online networking provides a more comfortable place to mingle and chat with other firms. But some still struggle to unlock any value from networking, online or in person. The strategies for getting results from networking are very similar, whether it's on Twitter or at your local Chamber of Commerce. I spoke to professional networker Lorna Trent to get her tips on how to not just become successful at networking, but also how to make it a pleasure!
Lorna Trent gets paid to network on behalf of other firms. She has nearly 20 years of networking experience, 10 of those gained at Dorset Chamber of Commerce and Industry (DCCI). At DCCI she helped reinvigorate a networking programme, which grew from 10 events to over one hundred per year.
As a result of the networking opportunities they created, DCCI came second in a national competition for Excellence in Networking.
Arranging events aimed at different types of business networkers was central to DCCI's strategy, said Lorna. They varied the size, theme and venue of their many meetings.
Business networking tip #1: Find a networking group or format that you're comfortable with. Some groups are very unstructured, while others are quite the opposite. Visit different types of meeting to get a feel for which format would suit you.
Networking generates income
A common complaint from non-networkers is that they tried it but it didn't bring in any business.
After her time at DCCI, Lorna went to the non-profit housing organisation BCHA, as fundraising manager. Lorna spent much of her time networking and identified that around 60% of donations came through networking contacts.
Business networking tip #2: Give networking time to get results. Whether you're tweeting as part of #dorsethour or going to your local Chamber business breakfast, don't expect to come away from your first or even second meeting with some hot business leads. Be patient and they will come.
Learn to enjoy networking
Lorna-Trent-smll
After leaving BCHA, Lorna spent time working out what she wanted to do next. Whilst analysing what she was good at and really enjoyed doing, she identified her strength in business networking. Could this strength be converted into a business?
What Lorna really enjoys about business networking is connecting people. She listens to people talking about their situation, their needs and aspirations, and she spots opportunities to connect them with someone who could be able to help.
As a result of helping others, Lorna also helps the organisations she represents. People like and trust her - key ingredients to securing business, donations or support.
Business networking tip #3: A great way to start networking is to ask people about themselves and to listen with genuine interest. The best networkers listen more than they talk.
The benefits of a professional business networker
Today, Lorna goes to several networking events each month on behalf of her clients. She was initially surprised that most of her clients were already busy networkers themselves. She had expected to be working for people who didn't want to network.
Because her clients are successful networkers, they know the power of business networking. They hire Lorna because they can't get to as many networking meetings as they'd like.
Lorna makes it clear that she's not a sales rep for her clients. Her role starts and ends with business networking, where she connects people who have needs with those who could help supply what's required.
Business networking tip #4: Accept that most people you meet at a networking event are there to sell. Listen to what they have to offer, because it could help you or someone you know, and by helping someone they then become keen to help you.
Making business networking work for you
Lorna does not use social media. She set up a Twitter account three years ago and has tweeted once. For her, networking is about meeting people face to face.
However, the networking principles she describes - listening to people, connecting people, and building trust - apply whether you're networking through tweets or at a breakfast meeting.
However, there was one tip I wanted from Lorna that particularly applies to an offline or real-world networking event: how do you find someone to talk to at a networking meeting when everyone else seems to be chatting away?
I recommend that you turn up early to networking events, because that way it's easier to engage in conversations as people arrive. But what happens if you turn up later and the room is packed with small groups chatting away over coffee? How do you avoid wasting your time by being a wallflower?
Business networking tip #5: Look at the body language to find a group that's still in the shallow end of a conversation. They're exchanging pleasantries but nothing serious. They'll welcome someone new into the group and some will even be grateful to have another person to talk to.
Business networking in Dorset
There are networking groups in Dorset to suit all tastes. Some are referral groups that only allow one member per trade or profession and try to keep a score of how much business they've generated. Others offer little more than somewhere to chat over coffee and a breakfast.
There is no 'right' or 'wrong' approach to networking. There's just what works for you and what doesn't. Here's a list of business networking groups in Dorset.
To find out more about how Lorna Trent and Parrot can help you with business networking, click here.
The social media harvest of a growing Dorset business
How to use Twitter lists
Dorset business, GuidesAndrew Knowles 26 January 2016 Comment
Dorset businesses that blog
Blogging is a great way to keep adding fresh, highly quality content to your website, something that Google recommends as a way of keeping your visibility high on search engines. Blogging is also a great way to demonstrate credibility to potential customers, because it shows that you know what you're talking about.
This post is a list of the Dorset businesses and charities I know of that blog. No doubt there are others and if you know of one, please tell me.
ClickForTraining-inBlogimage
List updated April 2016
Cater Data
Christchurch Harbour Hotel
Comins Tea House
Concept Photographic
Dorset Orthopaedic
Dream Cottages
Dorset Wildlife Trust
Fox Inn Ansty
Goldhill Organics
Hixons Business Advisors
In the Bag PR
Intergage
IT Support 365
Medisave
Morris Lane Chartered Accountants
Roving Press
Salterns Harbourside Hotel
Yellow Book Interiors
Criteria to be included on this list of Dorset businesses that blog:
- The blog must be written by a business or charity based or headquartered in Dorset. - The latest post must be dated no more than six months earlier than the date when I visit the blog. - There must be at least five posts on the blog, with varying dates. - Ideally the blog posts should be dated, or at least give a clue to their date, to indicate how current they are.
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Blogging, Dorset businessAndrew Knowles 15 November 2015 marketing, small business, DorsetComment
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Andrew Knowles has business experience from corporate, charitable and start-up environments. He started Dorset Social to provide training to local businesses in social media and technology. Andrew is an active member of the Weymouth business community and President of the Weymouth and Portland Chamber of Commerce for 2017-18.
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Gallery / Image / Media / Middle East / News / Opinion / Yemen
Latest Updates On Yemen 5 May 2018; The US Official Presence in the War Against Yemen
Monday, 7 May 2018 - 11:14
The United States presence in the Yemeni war and cooperation with the Saudi-led coalition is not a new issue, but the official announcement and emphasis on confronting Iran's threats in the region, as well as what they call as"Iranian missiles in hands of the Houthis" is a challenge that is related to the political developments of these days against Iran!
1. The joint meeting of Iran and European countries (Britain, Germany, France and Italy) in Rome in order to examine the Yemen political solution ended with no specific result.
Subsequent sessions were postponed to the following months.
2. Emirati forces after entering Socotra island and capturing the port and the airport, did not allow the flight and departure of Mansour Hadi's government members.
Lately, political disputes between the Southerners (backed by the UAE) and the Mansour Hadi forces (backed by Saudi) have led to military conflicts in southern Yemen.
Hadi's forces also claim that the island is being seized by UAE. In this regard, Saudi crown prince Ben Salman has sent a committee to Socotra to investigate the recent conflict.
The Emirates now controls the island by sending troops and fighters.
3. The US Official Presence in the War Against Yemen.
The United States Department of Defense In addition to its military presence in Yemen along with the Saudis and the exchange of information, etc… stated: "The purpose of the presence of US troops alongside the Saudis is not for military or conflict engagement, but for guidance and training for the Saudi Army to destroy Iranian missiles!"
4. The disagreement between the parliament and the Sudanese government regarding Yemen.
Sudanese MPs have recently called for limiting interference in Yemen.
They criticized Sudan's heavy losses for the battles and demanded for Sudan foreign interests and stop interfering in Yemen conflict and support the peace in Yemen.
But the commander of Sudanese military forces in the Saudi coalition announced that the country's military will remain in Yemen to achieve all goals!
P.S:
But so far, it's generally possible to say that the US claim for Yemeni missiles, is in line with the pressure on Iran to begin another layer of talks (regional or missile, or both).
The Americans, with the Cold War illusion (especially the Cuban Missile Crisis), are trying to induce a new threat for the world and their allies, this time, Iran is their best option.
But keep in mind that the US is gradually withdrawing from the West Asia region and filling its place with the Saudi coalition, and this is just like the formation of "NATO" against the "Soviet Union"!
Image: The rally of the Yemeni people in Sanaa, titled "Qods is the land and the first Qibla of Muslims"
Emirati forces ISWNews ISWNews.com Saudi Saudi Arabia Socotra Sudan UAE US Yemen Yemen news Yemen war


MGFTSMED11 Inglewood Series 2 Piece Gift Set with Twist Off Cap Rollerball Pen and Multi-Purpose Pocket Knife in Rosewood, Laser Engraved 25 piece minimum order. Imprint area (Pen): 5/16" x 1-3/4". Imprint area (Knife Handle): 3/4" x 1/4". Standard packaging is a gift box.


Tarantulas are not for everyone, but the brave folks who keep them as pets love them as much as anyone can love a spider. Tarantulas, though they look quite fearsome and strike fear in the hearts of many, really are quite fragile and can suffer injuries during molting.
Molting is a natural process experienced by animals with an exoskeleton. As the animal grows, the outer shell, or carapace, does not grow with it, so it must be discarded in favor of a newer, bigger one. This process of molting involves the animal shutting down for a time while he sheds his outer skin and emerges with newer, softer skin, which will quickly harden into a new exoskeleton. Tarantulas molt about every six months and some continue to molt throughout their lives. When Mother Nature tells the spider it's time to molt, the spider begins to secrete special hormones and fluids that will help him evacuate the old shell. He will roll over on his back and you may see some silk around him. Do not disturb him as he is very vulnerable during this process, which can take anywhere from 15 minutes to a few hours. It's a complicated and dangerous time for a spider.
The most common problem during molting is for the spider to get stuck inside the old carapace. Most of the time it's just a small part of the body that is stuck, but sometimes the spider actually can become trapped inside the old carapace, which leads to a slow death. Molting problems usually are caused by a lack of sufficient hydration, or humidity. Molting requires lubrication, and without proper levels of humidity, 60 percent or higher, the process cannot continue. Spiders with regenerated legs, older spiders and malnourished spiders all are at a higher risk for molting injuries. The only time you should intervene during molting is if you see your spider having obvious trouble extracting himself from the outer shell. Gently apply moisture to the area where he is stuck, using a wet paintbrush, to help separate the old shell from the new skin.
Another common problem occurs with one or more of the legs during molting. If you see your spider having difficulty extracting a leg from the inside of the carapace, gently pull the old shell off the leg using a tweezers. Do this only if you see your spider has completed the molting process and is having trouble. If your spider has a deformed leg after molting, which happens sometimes with juveniles, wait a few days to see if it falls off on its own. If it does not, remove it with a hemostat or tweezers. If you don't, he will have trouble during his next molt.
Keep your tarantula well-nourished and hydrated at all times. Always offer fresh water, even if your spider appears to ignore it. When he needs it, he needs it desperately and if it's not available he could be in big trouble. The water should be offered in a shallow saucer so he can lower himself into it to drink. The ambient humidity should be at least 60 percent or higher. Remove any uneaten prey in the tank, as crickets and other insects are criminals of opportunity and will attack the spider when they see him go into molting mode. Know the signs when your spider is about to molt so you can be prepared: he will stop eating and become lethargic. The carapace becomes transparent and may split. His abdomen will darken and he may spin a web. Keep a close eye on him from a distance and watch nature take its amazing and spectacular course.
Does a Spider Have Bones?


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Congress urged to act fast on student loan interest rates
By Stacey Samuel, CNN
Washington (CNN) Freshman Tyler Dowden from Northern Arizona University has high aspirations for a career as a psychologist, but worries about his future have brought him to Washington with a petition for Congress not to raise interest rates on his Stafford student loans.
"I don't feel that I can be successful with this overwhelming debt strangling me. I can't really breathe because whenever I look around, whenever I look at my future or try to make goals for my future, I really can't. I have to take my massive debt into consideration," Dowden said.
His father is a firefighter and his mother works in retail. He is one of six children, and saving for college has been out of reach for his family, he said.
Dowden isn't alone. He is among nearly 8 million college students who could potentially have the interest rates on subsidized Stafford student loans nearly double from 3.4% to 6.8% if Congress doesn't act by July 1.
Filed under: College • Issues • Policy • Practice • video
Encyclopedia Britannica to stop printing books
By Julianne Pepitone, CNNMoney
NEW YORK (CNNMoney) - After 244 years, Encyclopedia Britannica will cease production of its iconic multi-volume book sets.
Britannica usually prints a new set of the tomes every two years, but 2010's 32-volume set will be its last. Instead, the company will focus solely on its digital encyclopedia and education tools.
The news is sure to sadden champions of the printed word, but Britannica president Jorge Cauz said the move is a natural part of his company's evolution.
"Everyone will want to call this the end of an era, and I understand that," Cauz says. "But there's no sad moment for us. I think outsiders are more nostalgic about the books than I am."
Filed under: At Home • Practice • Reading • Resources • Technology
How 'trigger laws' empower parents
CNN's Kyra Phillips questions Christina Sanchez of Parent Revolution about laws that enable parents to take over public schools.
For more information, read the Five minute primer: Parent trigger laws.
Filed under: Issues • Parents • video
A-M-A-Z-I-N-G: Girl, 6, becomes youngest eligible for Scripps Spelling Bee
Can you say extraordinary?
I suspect that 6-year-old Lori Anne Madison can spell it – and it's one of the best words to describe her.
The young girl from Prince William County, Virginia, has just become the youngest speller eligible to participate in the Scripps National Spelling Bee, according to the event's record books, which date to 1993. Mike Hickerson, the bee's communications manager, said there have been four spellers since 1993 who were 8 years old.
Lori Anne, who is home-schooled, beat out 21 other kids in the county to win the bee, which enters her into the national bee.
The word that thrust her into the spotlight? "Vaquero," the Spanish translation of "cowboy," which is often used in Spanish-speaking parts of the South such as Texas, according to InsideNova.
The paper reported that after one of the last spellers missed her word, Lori Anne stepped up to the microphone, was given her word and without hesitation rattled off the spelling correctly.
Read the full story from This Just In
Filed under: Elementary school • Practice • Spelling • Students
Five minute primer: Parent trigger laws
by Donna Krache, CNN
(CNN) Last Friday, Florida's state senate narrowly defeated a proposed "parent trigger" bill. In more than 20 states, legislatures are considering or have taken action on parent trigger bills, which are designed to empower parents to take action on failing schools by firing staff, transferring students or creating a new school.
How do parent trigger laws work?
State proposals and laws vary, but in essence, if a school fails to demonstrate academic achievement among its students according to predetermined benchmarks (for example, test scores), under parent trigger laws, a majority of parents could determine that some or all teachers and administrators should be dismissed and new staff brought in. Under some state proposals, action by a majority of parents could close the school altogether or hand over management of a school to a private corporation or organization and re-establish the school as a charter school.
Proponents of parent trigger laws say that they empower parents, especially those of students in low-performing schools, to be able to turn schools around and provide their children with the best opportunity for a good education. They say it gives parents an option that they currently do not have. Often these parents lack the means to provide other options, such as a better public school or a private school for their kids, they say.
California was the first state to pass a parent trigger law, in January 2010. The primary force behind its passing was Parent Revolution, which, according to its website, makes this promise to parents: "Organize half the parents at your children's failing school to demand change, and we will stand with you and empower you to fight for the great school your children deserve."
Posted by Donna Krache CNN
Filed under: Five minute primer • Policy


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Report: Ben Howland Frontrunner for Mississippi State Basketball Head Coach
Not long after Mississippi State announced that it would part ways with Rick Ray, Ben Howland's name has been floated as the next head coach.
By justinrsutton Mar 22, 2015, 6:23pm EDT
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ESPN's Jeff Goodman reported Sunday afternoon that Ben Howland is in the pole position to be the next head coach of Mississippi State basketball.
Ben Howland has emerged as the frontrunner and is in discussions to take the Mississippi State job, sources told ESPN.
— Jeff Goodman (@GoodmanESPN) March 22, 2015
Howland, who last coached UCLA, taking the Bruins to the Final Four in 2008, would provide a much different direction than the last time the Bulldogs made a basketball coaching change. That last change saw an assistant coach take the reigns at Mississippi State after Rick Stansbury was relieved of his coaching duties.
Without a doubt, there is pressure on Scott Stricklin to make a solid hire for the position given how things sorted out with Rick Ray. With much of the fanbase clamoring for a proven head coach, hiring Howland could make many of the fans happy.
However, some fans may feel concern at the situation given the way Howland, according to a Sports Illustrated article, handled Reeves Nelson at UCLA. The article claimed that Nelson bullied many people and even went as far as to try to intentionally injure teammates. Worse, the article claimed that Howland looked the other way at this behavior, a charge that UCLA and the coach denied. Some Mississippi State fans may worry that this sounds too much like Renardo Sidney and Stansbury.
On the positive side, Howland is a coach that has taken three programs to the NCAA tournament, including taking UCLA to the Final Four. Additionally, Howland turned around Pittsburgh and UCLA in quick fashion after taking over both programs when they were in a state of struggle, a more than fair description of Mississippi State basketball right now.


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Q: Android saving data from sensor in internal storage file not found I am now working on my first android project, including saving data from the sensor on the phone for 15 minutes after the mainAcitivity called. Considering sometimes there may not be sd card in the phone, I decided to store the files on internal storage.
Now I have stuck it these problems for a few days:

*

*After saving the data I have returned the directory with getFilesDir(), but I couldn't find the showed route anyway.
screen shot after running service
/data/user/0/com.example.liya.medicinecalendar/files/201807100711.txt

*The service according to the toast sometimes starts and ends not as wished.
In MainActivity.class I just used
startService(new Intent(MainActivity.this,SaveSensorService.class));

I didn't create a thread because I don't wanna let screen activity and service run at the same time.
Here is my SaveSensorService.class
public class SaveSensorService extends Service implements SensorEventListener {

    private static final String TAG = "SaveSensorService";

    private Float xValue, yValue, zValue, xGyroValue, yGyroValue, zGyroValue;
    SensorManager sensorManager;
    private Sensor accelerometer, mGyro;

    private SimpleDateFormat Date_Format,Newtime_Format;
    private  Calendar calendar;
    private String StartTime, StopTime, CurrentTime, FileName;

    @Nullable
    @Override
    public IBinder onBind(Intent intent) {
        return null;
    }

    @Override
    public int onStartCommand(Intent intent, int flags, int startId) {
        Log.d(TAG, "onStartCommand: SaveSensorService started.");

        Newtime_Format = new SimpleDateFormat("HHmmss");
        calendar = Calendar.getInstance();
        StartTime = Newtime_Format.format(calendar.getTime());
        CurrentTime = StartTime;
        //calendar.add(Calendar.MINUTE, 15);//save sensor data for 15min
        calendar.add(Calendar.SECOND,60);//for test
        StopTime = Newtime_Format.format(calendar.getTime());
        Toast.makeText(SaveSensorService.this, StartTime+" SaveSensorService is running",Toast.LENGTH_SHORT).show();

        Log.d(TAG, "onCreate: Initializing Sensor Services");
        sensorManager = (SensorManager) getSystemService(Context.SENSOR_SERVICE);

        accelerometer = sensorManager.getDefaultSensor(Sensor.TYPE_ACCELEROMETER);
        if (accelerometer != null) {
            sensorManager.registerListener(SaveSensorService.this, accelerometer, 5000000);
            Log.d(TAG, "onCreate: Registered accelerometer Listener");
        } else {
            xValue = null;
            yValue = null;
            zValue = null;
            ;
        }

        mGyro = sensorManager.getDefaultSensor(Sensor.TYPE_GYROSCOPE);
        if (mGyro != null) {
            sensorManager.registerListener(SaveSensorService.this, mGyro, 5000000);
            Log.d(TAG, "onCreate: Registered Gyro Listener");
        } else {
            xGyroValue = null;
            yGyroValue = null;
            zGyroValue = null;
        }

        if ((accelerometer!=null || mGyro != null)&&CurrentTime.compareTo(StopTime) < 0) {
            calendar = Calendar.getInstance();
            CurrentTime = Newtime_Format.format(calendar.getTime());
            saveSensor();
        }

        else  {
            stopSelf();
            Toast.makeText(SaveSensorService.this,"Time's up or device not support."+ CurrentTime,Toast.LENGTH_SHORT).show();

        }

        return START_STICKY;
    }

    @Override
    public void onDestroy() {
        Log.d(TAG, "onDestroy: SaveSensorService stopped.");
        Toast.makeText(SaveSensorService.this,"Sensordaten wurden gespeichert."+ CurrentTime,Toast.LENGTH_SHORT).show();
    }

    /*********** save the sensor data during the set time - START *******************/

        public void saveSensor () {

            //create a new file, named by the current time
            Date_Format = new SimpleDateFormat("yyyyMMddHHmm");
            FileName = Date_Format.format(calendar.getTime())+".txt";

            try{
            FileOutputStream fos = null;

                //to prevent that the file fail to be read or created, use catch to print the error
                // write in txt,

                fos = openFileOutput(FileName, MODE_APPEND);
                //write the first line - description
                fos.write("xValue\tyValue\tzValue\txGyroValue\tyGyroValue\tzGyroValue\r\n".getBytes()); //define the first line

                    //append the sensor data in the file
                    fos.write((xValue + "\t" + yValue + "\t" + zValue + "\t" + xGyroValue + "\t" + yGyroValue + "\t" + zGyroValue + "\r\n").getBytes());
                    fos.flush();
                    fos.close();
                } catch (FileNotFoundException e1) {
                e1.printStackTrace();
            } catch (IOException e1) {
                e1.printStackTrace();
            }
            Log.d(TAG, "onClick: file ist written.");
                Toast.makeText(this, "Saved to " + getFilesDir() + "/" + FileName, Toast.LENGTH_SHORT).show();

            }

    @Override
    public void onAccuracyChanged(Sensor sensor, int accuracy) {
    }

    @Override
    public void onSensorChanged(SensorEvent sensorEvent) {
        Sensor sensor = sensorEvent.sensor;

        //get accelerometer data
        if(sensor.getType()==Sensor.TYPE_ACCELEROMETER) {
            Log.d(TAG, "onSensorChanged: X:" + sensorEvent.values[0] + "Y:" + sensorEvent.values[1] + "Z:" + sensorEvent.values[2]);

            xValue = sensorEvent.values[0];
            yValue = sensorEvent.values[1];
            zValue = sensorEvent.values[2];

        }

        //put gyrocope data
        else if(sensor.getType()==Sensor.TYPE_GYROSCOPE) {
            Log.d(TAG, "onSensorChanged: XG:" + sensorEvent.values[0] + "YG:" + sensorEvent.values[1] + "ZG:" + sensorEvent.values[2]);

            xGyroValue = sensorEvent.values[0];
            yGyroValue = sensorEvent.values[1];
            zGyroValue = sensorEvent.values[2];

        }

    }

    /***************** save the sensor data during the set time - END *************************/

}

And here is my AndroidMainifest.xml
   <?xml version="1.0" encoding="utf-8"?>
<manifest xmlns:android="http://schemas.android.com/apk/res/android"
    package="com.example.liya.medicinecalendar">
    <uses-permission android:name="android.permission.WRITE_EXTERNAL_STORAGE"></uses-permission>
    <uses-permission android:name="android.permission.READ_EXTERNAL_STORAGE"></uses-permission>

    <application
        android:allowBackup="true"
        android:icon="@mipmap/foreground"
        android:label="@string/app_name"
        android:roundIcon="@mipmap/ic_launcher_round"
        android:supportsRtl="true"
        android:theme="@style/AppTheme">
        <activity android:name=".MainActivity">
            <intent-filter>
                <action android:name="android.intent.action.MAIN" />

                <category android:name="android.intent.category.LAUNCHER" />
            </intent-filter>
        </activity>
        <activity android:name=".CalendarActivity"></activity>
        <service android:name=".SaveSensorService"
        android:enabled="true"/>
        <receiver android:name=".AlarmReceiver"></receiver>
        <service android:name=".AlarmService"
            android:enabled="true"/>
    </application>

</manifest>

I will be so grateful if someone can give me some advice to solve this problem when saving data. Thank you so much in advance!


text:
International Livestock Research Institute2019 Annual Report
In the lab
The ILRI 2018 Annual Report> Capacity building
ILRI/Apollo Habtamu
Woman holding egg
ILRI recognized at the 2018 World Food Prize
Wellington Ekaya
Head of Capacity development
ILRI has participated in the WFP's internship program for nearly 20 years
The prestigious World Food Prize Borlaug-Ruan International Internship provides high school students an eight-week, hands-on experience working with world-renowned scientists and policymakers at leading research centres around the globe. Since 1998, the World Food Prize has sent over 300 students on Borlaug-Ruan International Internships at 34 of the world's top agricultural research centres. Through the internship program, the student becomes an integral part of her or his assigned project, spending time in the lab, as well as days or weeks at a time in the field, conducting research and gathering data.
The International Livestock Research Institute (ILRI) has participated in the Borlaug-Ruan International Internship since the program began, 19 years ago. Twenty-three United States (US) high school students participated in an internship at ILRI. ILRI recently asked former participants about their experience and how it shaped their lives. A few of the responses, edited for length and clarity, follow.
Wellington Ekaya, ILRI's head of capacity development, received a Plaque of Appreciation at last year's World Food Prize Convention and Award Ceremony in Des Moines, Iowa, US, on behalf of ILRI and joined the World Food Prize international roll of mentors. The plaque was in recognition of ILRI's continuing participation in the prestigious World Food Prize Borlaug-Ruan International Internship program. In his acceptance remarks, Ekaya said that 'capacity development is one of ILRI's three strategic objectives, and so it is always a pleasure and privilege to mentor young minds into agriculture, and to grow the next generation of global leaders'.
Alisa Evans (2018)
My internship crystalized my goal of wanting to become a veterinarian and work in the developing world. It made me more aware about the specific causes of global food insecurity from diseases such as East Coast Fever and how these diseases can be controlled. If we can control livestock diseases, then more meat will be available and we can eventually eliminate world hunger.
Sydney Sherer (2018)
My internship at ILRI opened my eyes to a lot of the issues that our world is facing and will face in the future when it comes to food insecurity. I was also able to gain first-hand experiences with policy makers and scientists in Kenya who are leading the way when it comes to developing better policies and technologies regarding a wide range of topics from women's education to the accessibility of healthcare in rural areas. This experience also allowed me to see first-hand how hard it is for scientists to get their improved technologies accepted by the government and then by the people. This process is necessary to ensure the safety of consumers, but it is hard for scientists to navigate this process on their own. That is why I will eventually pursue a degree in Food and Agricultural Law.
Hannah Heit (2017)
I served as a Borlaug-Ruan Intern at ILRI in Addis Ababa, where I conducted research on an improved breed of chicken. My experience with ILRI allowed me to solidify my passion for combating food insecurity through improving animal agriculture. I am currently an undergraduate but I plan to pursue a Master in Public Health and Doctorate of Veterinary Medicine with hopes of reducing the prevalence of zoonotic diseases which threaten the livelihoods of smallholder farmers in Africa. I am very grateful for the opportunities that ILRI provided me because they helped shape my career goals of combating global food insecurity and improving the world's food supply through international agricultural development and veterinary medicine.
Dylan Lampe (2016)
This internship completely reshaped my world view when it came to global food insecurity. Back in high school, I did a lot of research on food insecurity, and I thought I knew what I was talking about. Of course, living in Iowa, most, if not all, of my research was very abstract. I never put a face to these issues. I didn't know what true poverty looked like or how people were fighting to get food out of some of the most infertile soil in the world. This inspired a passion in me to help combat global food insecurity for the rest of my life.
Trisha Web Collins (2010)
My experience at ILRI really opened up windows of opportunity for me, especially at Iowa State University. I came from a small high school with limited science equipment, but my internship at ILRI put me a step ahead of my peers and I got a job at the college's world-renowned diagnostic laboratory as an undergraduate freshman. This eventually led to a variety of internship and job opportunities within the United States Department of Agriculture (USDA) Animal and Plant Health Inspection Service, USDA Agricultural Research Service, and even in private pharmaceutical companies like Boehringer-Ingelheim.
I learned about the importance of not only research, but extension and direct application to farmers in the field. This helped prepare me for a summer experience working alongside the Iowa State College of Ag and Life Sciences and the Food and Agriculture Organization of the United Nations, writing a published research paper on the importance of safeguarding genetic biodiversity in different cattle breeds. This also led to my interest in the double major of international agriculture as an undergrad and my Master in Public Health which I pursued along with my professional school. ILRI taught not only the importance of science and research, but also extension and application to farmers in the field. What good is a new technology if it cannot be put to good use?
I am just getting started in my career, and my long-term plans are to work directly with livestock and food security on an international level. I would not have this passion and interest without ILRI.
Abbey Canon (2004)
With the support of the World Food Prize and ILRI at age 19, I completed a research project concerning international nutrition and animal-source foods. Surveying the Ethiopian meat industry gave me an unimaginable opportunity to immerse myself in international public health and experience a beautiful country and culture.
Since interning at ILRI in 2004, I obtained a Bachelor of Science degree in animal science and international agriculture, a Master of Public Health degree, a Doctor of Veterinary Medicine degree, and became board certified as a specialist in veterinary public health. I have held various roles in veterinary public health with the Centers for Disease Control and Prevention, local and state health departments, veterinary colleges, and food security and public health organizations. In almost all of my roles, I focus on improving human health through animal health.
My placement at ILRI, the fantastic and flexible mentorship I received, and the opportunities it opened when I returned were exactly why I chose and have been successful in my career path.
Jerad Chipman (2003)
My Borlaug-Ruan Internship at ILRI in Ethiopia has had a substantial effect on my career and personal outlook. I grew up on a farm in western Iowa. I appreciated the farming lifestyle, but I knew that farming was not going to be my long-term career path. I am currently serving as a senior planner at the Village of Montgomery, Illinois, a career that is a direct result of the time that I spent in Ethiopia, learning about people, cities, governments and nations. In my role as a municipal planner, I am able to work with the community towards the goals of sustainability, equality and progressing towards a better built environment. The internship has also inspired me to travel as often as possible.
Shawn Thomas (2002)
My internship at ILRI in Ethiopia in 2002 has had an impact on my entire career. Following my internship, I pursued ecology and animal science. I then became a veterinarian. After initially focusing on small animal medicine, my interests shifted towards public health. I have since commissioned in the US Army. As an Army veterinarian, I now work in food safety and public health (human and animal health), both in the US and throughout the world.
My internship at ILRI was the first time I had ever left the US. It opened me up to a new world and new experiences. It also taught me lessons I continue to use throughout my career. Before ILRI, I had never worked with large animals or milk. Some of the lessons I began learning at ILRI included how to talk to and work with people from different backgrounds, how to work (and milk) cattle, and how to collect and analyse scientific data. As my career progressed, I have had many other teachers of these lessons, but working in the dairy co-operative in Debre Zeit, Ethiopia, spending afternoons in the barns and stables at ILRI, and working with the scientists at ILRI is where I had my very first lessons. These have stuck with me my entire life.
Ambassador Kenneth Quinn, president of the World Food Prize Foundation, had this to say regarding ILRI's contribution to introducing young minds to agriculture through hosting the international interns:
Given the exceptional research achievements and extraordinary leadership of ILRI, it has been an unparalleled honor to partner with ILRI on the Borlaug-Ruan International Internship. Since 2001, ILRI has inspired 23 US high school students to pursue education and careers in animal science and agriculture. And, as a direct result of the mentorship they received from the staff at ILRI, are now seeking solutions on how to sustainably and nutritiously feed the over nine billion people who will be on our planet in 2050. Dr Norman Borlaug, the founder of the World Food Prize Foundation, was incredibly grateful for this collaborative partnership, which we continue in his honour.
Borlaug-Ruan International Internship program
Mentoring women to become future leaders in science
ILRI's support for South-South partnership to improve food safety in Asia
ILRI | International Livestock Research Institute
CGIAR
The Human Face of Sustainable
Livestock Development
Ethiopian girl drinking milk produced by the family cow
Jimmy Smith (l) received a doctorate with honoris causa and gave the commencement speech at the University of Melbourne, Australia, on 6 Dec 2018, with Lindsay Falvey (r).
2018 was a year of continuing progress and solid achievement for ILRI—and for that we remain both grateful and proud. Thanks to our staff, our partners, our donors and the governments with whom we work, ILRI is helping countless farmers and other stakeholders in the livestock sector in the developing world live better lives through livestock. It is helping to raise household incomes, improve human nutrition and health, fight devastating livestock diseases, breed more productive and drought-resistant animals, redress gender imbalances, enhance biodiversity and develop livestockrelated policies that will address, mitigate and adapt to climate change.
In past reports, we've noted that the global demand for animal-source foods continues to grow rapidly in developing and emerging countries, a phenomenon we've dubbed the "livestock revolution." In Africa, for example, the demand for livestock-derived foods is projected to increase by 80% from 2010 to 2030, mostly because of population growth. Asia, already the largest consumer of livestock-derived foods, will see a nearly 60% jump in consumption—and much of that will be due to rising incomes and greater urbanization.
The breadth of the opportunities these figures represent requires new science and new research results that are taken to scale. This report highlights just a few of the many activities ILRI staff have undertaken in the past year.
felixioncool
Good science is the foundation of ILRI's work
Novel index developed to measure women's empowerment in livestock production
RHoMIS: A rapid, standardized and cost-effective tool for tracking agricultural performance
Building a bioinformatics community for agricultural sciences in Africa
ILRI Information products 2018
ILRI/Zerihun Sewunet
ILRI is committed to research for development
Using smartphones to track livestock disease outbreaks in northern Kenya
Scientists and farmers swap information for more profitable milk production
Converting straws and stover into concentrates
Securing rangelands and settling conflicts through village land use planning in Tanzania
ILRI Offices and staff worldwide
Building local capacity and mentoring the next generation of agriculture scientists
ILRI.org site usage
Top 2018 science publications from ILRI programs
We thank ILRI's many partners and donors


Bjørvika, Oslo's former container port, was built on reclaimed land adjacent to the founding medieval settlement of the city. As part development named Fjord City (1980s and approved in 2003), Bjørvika is undergoing radical structural change. This involves the relocation of the central highway under the fjord, the construction of a central business district and thousands of new waterfront apartments, and the dedication of public spaces woven between those new buildings as allmenningen (commons). The development is highly contested. 'Slow Space', Situations' vision for the permanent programme, was developed from 2010 as part of the developer Bjørvika Utvikling's progressive approach to public art commissioning, along with the ongoing support of the Oslo Konsthall. Enter Futurefarmers, a network of artists, researchers, designers, farmers, scientists and engineers, whose common interest is in creating work that challenges current social, political and economic systems. Futurefarmers deconstruct systems such as food policies, public transportation and rural farming networks to consider alternative ways of living.
Flatbread Society, conceived by Futurefarmers including Amy Franceschini, Stijn Schiffeleers, Lode Vranken and Marthe Vandessel, grew as a constellation of farmers, oven builders, astronomers, artists, soil scientists and bakers through conversations and actions in Oslo and elsewhere from 2011. The physical home of Flatbread Society is an unpromising site on Loallmenningen, one of the Bjørvika commons under the road tunnel's ventilation shafts – the harbour's twin towers between the fjord and the medieval park. Futurefarmers formed Flatbread Society – a proposition to build a public baking facility housed within an experimental architectural structure – as the organizing principle of their project in Oslo, through which they environmentally respectful form of grain production and cultivation. The change in land use at Loallmenningen was signalled by a parallel project – Herligheten – in which one hundred allotment beds were given away to Oslo residents.