text:
When Did The Anasazi Vanish
September 20, 2018, 4:07 pm / facebookchacobook39360.onesmablog.com
The Anasazi civilization belonged to the Indigenous American descent that thrived during the U.S. Southwest among 750 and 1150 C.E. For the duration of their existence, they learned tips on how to learn pottery, astronomy and architecture. A lot of the tribes learned the best way to acquire sophisticated irrigation systems which fed massive fields of beans, maize and squash.
The Anasazi also developed intricate metropolitan areas of earth and stone that perched large earlier mentioned the ground inside the faces from the cliff. Other structures were sprawled on desert-ground spots and ended up thoroughly organized based on the formation of the heavens.
Suddenly, the advanced Modern society on the Anasazi began to break down toward the top with the 12th century. At the peak of its "golden age" era, the people "ran absent" from their ancestral habitations in just one sweeping and inexplicable exodus.
One noteworthy detail with the movement is definitely the notion which the Anasazi left at the rear of their possessions which involve their pottery and applications. A number of them even went so far as burning their residences together with their ceremonial properties.
This abrupt migration with the Anasazi brought numerous scientists to decades of knowledge and acquiring the reasons that may explain the phenomenon. Many theories have because been formulated as experts make an effort to fill the unsolved hole which includes haunted the globe of anthropology until finally the existing.
Cataclysmic Party
A cataclysmic party was believed to acquire happened towards the top of the 13th century which can have compelled the Anasazi to go away their cliff properties and their homeland so that you can shift east and south toward the Very little Colorado River and the Rio Grande. Archaeologists have observed the occasion as the best puzzle of ancient culture that should be solved. The Pueblo Indians of currently have their very own version of oral history that concentrates on their men and women's migration. Even so, the details encompassing the tales have remained as large secrets read more and techniques.
Horrible Drought
Specialists also focused on environmental explanations and chose to use the info from tree rings to seek out solutions. They learned that from 1276 to 1299, a terrible drought had hit the Southwest. Probably, sure places have pretty much no rain for 23 many years. Also, the Anasazi can have Nearly deforested the region introduced by chopping down the trees for firewood and for use as roof beams.
Nevertheless, it was also learned which the Anasazi, through the hundreds of years, are in the position to climate equivalent crises. Just one instance is the drought that occurred in between 1130 and 1180 which was longer plus more significant. Throughout this era, the Anasazi did not run with the cliffs nor abandon their homeland.
Extensive-Long lasting Violence
Aside from weather issues, the Anasazi had to endure lengthy-lasting violence which tore aside their lifestyle. Small archaeological proof of legitimate warfare was recorded while in the 11th and early Portion of the 12th century. Scientists have famous about the executions that happened during the period of time. Goon squads have existed. There were executions and acts of cannibalism which were committed via the governing framework. Due to this fact, a Culture-broad paranoia was created. The Anasazi people today lived in consistent worry.
Comments on "When Did The Anasazi Vanish"


Entest BioMedical said this week that it has kicked off an internal bioinformatics effort that will sift through clinical information as well as -omics and pathway data to explore whether existing drugs can be applied to chronic obstructive pulmonary disease and to identify potential biomarkers for COPD.
The firm's bioinformatics-based program will "integrate existing and newly generated data," including -omics information, about COPD, the company said.
Rather than focus on finding "new pieces" to the puzzle of COPD, the researchers want to make "sense of the pieces we already have," Feng Lin, Entest's scientific director, said in a statement.
"We have begun a program based on using various automated algorithms to mine existing data sets and develop hypotheses that can be experimentally tested," Lin said.
Entest is a La Mesa, Calif.-based firm and a subsidiary of Bio-Matrix Scientific Group that is focused on stem cell therapies for COPD, cancer immunotherapies, and medical device development.
The company said that the first step in the project will be the creation of databases containing "all genes associated with various aspects of COPD."
Company scientists will then categorize these genes based on biological functionality and association with each other, enabling a search function that will allow the company to explore, for example, which existing drugs may act somewhere on a relevant pathway "and possibility induce a benefit." the company said.
The bioinformatics approach will give Entest the opportunity to "develop new intellectual property, some of which we anticipate will include new uses of existing drugs on the market," said David Koos, chairman and CEO of Entest.
Entest said the project began when it began exploring ways to develop biomarkers for planned "photoceutical trials" of its therapeutic candidates.
Last month, the firm and academic collaborators published in the Journal of Translational Medicine an outline of its approach to treating COPD with a stem cell-based therapy accompanied by the use of "low level" lasers, which induce photo-stimulation rather than the thermal effects of higher-energy lasers.


Five project to develop active travel or low carbon transport hubs, including the installation of a new hydrogen refuelling station, have scored £3.25m in funding from the European Regional Development Fund (ERDF).
Transport Scotland's objectives include increasing the number of ultra-low emission vehicles on Scottish road.
Announced by Scotland's Transport Minister Humza Yousaf, the projects include the development of the Broxden Low Carbon Transport Hub, Perth, featuring the introduction of a hydrogen refuelling station and the expansion of existing electric vehicle charge points. The hub will also introduce an ultra-rapid (150kW) electric vehicle charge point, and upgrade the electricity sub-station for ultra-rapid charging.
Meanwhile Falkirk Council is to introduce a public-facing active travel hub in Falkirk town centre and a low carbon vehicle hub at Falkirk Community Stadium that will provide 20 electric vehicle charging bays and a 168-bay solar array to harness energy for charging at the low carbon hub.
The announcement of the projects follows last December's launch of the ERDF Low Carbon Travel and Transport (LCTT) Challenge Fund, which is open to public, third and community sector organisations and is intended to help drive Transport Scotland's objectives of encouraging drivers to turn to walking, cycling and public transport as well as increasing the proportion of ultra-low emission vehicles on Scotland's roads.


text:
On a Beautiful Day
Macmillan Digital Audio
Clare Wille
Audiobook PaperbackHardbackCDEbook Buy Amazon Audible iBooks Waterstones WH Smith
Treasure every moment. Life can change in a heartbeat.
What the fans say: 'Wonderful characters and the stories are always great, with twists and turns' Gemma
It's a beautiful day in Manchester and four friends are meeting for a birthday lunch. But then they witness a shocking accident just metres away which acts as a catalyst for each of them.
For Laura, it's a wake-up call to heed the ticking of her biological clock. Sensible Jo finds herself throwing caution to the wind in a new relationship. Eve, who has been trying to ignore the worrying lump in her breast, feels helpless and out of control. And happy-go-lucky India is drawn to one of the victims of the accident, causing long-buried secrets to rise to the surface.
This is a novel about the startling and unexpected turns life can take. It's about luck – good and bad – and about finding bravery and resilience when your world is in turmoil. Above all, it's about friendship, togetherness and hope.
Exclusive to the audiobook, On A Beautiful Day contains a unique Q&A session between the author and her editor.
Praise for Lucy Diamond:
'A hugely satisfying read' Heat
'An absolute treat' Katie Fforde, bestselling author of A Summer at Sea
'Warm, witty and wise' Daily Mail
Full of emotion and insight - it really makes you think
Katie Fforde, bestselling author of A Summer at Sea
This is about friendship and about being there for the ups, the downs and everything in between. It's warm, witty and wise
A new Lucy Diamond book is one of the happiest highlights of my calendar. On a Beautiful Day is a celebration of family, friendship and love and a poignant reminder to make the most of every day
Cathy Bramley, bestselling author of The Lemon Tree Cafe
Books by Lucy Diamond
Something to Tell You
The House of New Beginnings
The Secrets of Happiness
Hens Reunited
Any Way You Want Me
Summer With My Sister
The Year of Taking Chances
Sweet Temptation
One Night in Italy
A Baby at the Beach Cafe
Summer at Shell Cottage
Christmas Gifts at the Beach Cafe
Christmas at the Beach Cafe
Lucy Diamond on the life-changing effects of new starts and New Year's resolutions
Lucy Diamond: What's on my bookshelf

redpajama_set_name: RedPajamaCommonCrawl


World Press is committed to environmentally sustainable manufacturing today and every day.
Happy Easter from World Press!
Happy Easter from everyone at World Press!
Are you looking for fresh thinking to take your printing projects to the next level? The new World Press WHEEL has some ideas. Contact your account rep for your copy.
What will the WHEEL reveal for you?
Do you maintain a critical eye when viewing your own work?


text:
namespace System.Security.Permissions
{

#if CONFIG_POLICY_OBJECTS && CONFIG_PERMISSIONS && !ECMA_COMPAT

using System;
using System.Security;

[AttributeUsage(AttributeTargets.Assembly |
			 	AttributeTargets.Class |
			 	AttributeTargets.Struct |
			 	AttributeTargets.Constructor |
			 	AttributeTargets.Method,
			 	AllowMultiple=true, Inherited=false)]
public sealed class ZoneIdentityPermissionAttribute
	: CodeAccessSecurityAttribute
{
	// Internal state.
	private SecurityZone zone;

	// Constructors.
	public ZoneIdentityPermissionAttribute(SecurityAction action)
			: base(action)
			{
				zone = SecurityZone.NoZone;
			}

	// Get or set the zone value.
	public SecurityZone Zone
			{
				get
				{
					return zone;
				}
				set
				{
					zone = value;
				}
			}

	// Create a permission object that corresponds to this attribute.
	public override IPermission CreatePermission()
			{
				if(Unrestricted)
				{
					throw new ArgumentException(_("Arg_PermissionState"));
				}
				else
				{
					return new ZoneIdentityPermission(zone);
				}
			}

}; // class ZoneIdentityPermissionAttribute

#endif // CONFIG_POLICY_OBJECTS && CONFIG_PERMISSIONS && !ECMA_COMPAT

}; // namespace System.Security.Permissions

redpajama_set_name: RedPajamaGithub


text:
Nvidia releases game-ready drivers for The Witcher 3: Wild Hunt
By Sherif Saed, Monday, 18 May 2015 20:05 GMT
Nvidia has released new game-ready drivers for The Witcher 3: Wild Hunt.
Driver 352.86 for Nvidia GPU owners is now live. The new driver ensures the game can be played at its maximum potential across a wide range of PCs.
Nvidia recommends installing the drivers before playing the game. Along with the promised optimisations, the driver also brings the latest SLI profiles to the library.
But that's not all. Nvidia has also published a very detailed performance tweak guide. The guide is a thorough look at all of the game's graphical settings, the effect they produce in-game, as well as the frame-rate hit they cause.
As with most of these guides, this is essential for anyone looking to maximise the game's frame-rate and graphical fidelity on their PCs.
The video below shows the full suite of Nvidia's GameWorks in action:


text:
25 LISTSLucky There's a Family Guy
Lists about Seth McFarlane's irreverent cartoon about Quahog's finest family, airing on Fox since 1999.
12.7k voters
The Best 'Family Guy' Episodes of All Time
Updated January 15, 2021 76.7k votes 12.7k voters 1.5m views313 items
List RulesVote for your favorite Family Guy episodes, no matter how popular they are.
List of the best Family Guy episodes, as determined by voters like you. With all the amazing episodes of the show that exist, it's hard to trust just one person's opinion of what the top Family Guy episodes of all time are. Fans will also enjoy hilarious pictures of real people who look like Family Guy characters and disturbingly dark Family Guy jokes. The first three seasons of MacFarlane's hit cartoon are so classic, but many believe the show hit its stride in seasons 4-7. Fans of Family Guy are very passionate about the show, and there are often debates over which episodes are the greatest. That's why this list exists- so you can vote for your favorites and we can find out once and for all what everyone thinks the funniest Family Guy episode of all time is. Considers this your definitive guide to the best Family Guy episodes featuring the greatest moments from characters like Peter, Stewie, Brian, Lois, Chris, and that other girl.
If you're wondering what the top 10 Family Guy episodes are, this list shows you guys the answer!
List features the Stars Wars specials like "Blue Harvest," and "It's a Trap!" and some funny new Family Guy episodes like "The Simpsons Guy" where the Griffins finally meet the residents of Springfield in an epic crossover. What is the best Family Guy episode of all time? What episodes really grind your gears? List features almost every Family Guy episode, but some of the newest ones might be missing if you want to add them. Including good episodes, highest reviewed episodes, the rudest episodes, top rated episodes, and the funniest Family Guy episodes, this list has it all.
And Then There Were Fewer
In this murder mystery special, The Griffins as well as all the other major characters become... more on Wikipedia
Road to the Multiverse
With the help of an out-of-this-world remote control, Stewie and Brian travel through... more on Wikipedia
Back to the Pilot
Season 10, Episode 5
"Road to the Pilot is the fifth episode of the tenth season of the animated comedy series... more on Wikipedia
Season 4, Episode 14
After a "wardrobe malfunction" occurs during a live broadcast, the FCC begins to censor all of... more on Wikipedia
Petarded
After winning a game of Trivial Pursuit, Peter is convinced he is a genius. To prove Peter... more on Wikipedia
Stewie Kills Lois
Lois and Peter sail off on a cruise. Jealous that he was left behind, Stewie's matricidal...
Road to Germany
Mort Goldman accidentally steps into Stewie's time machine and goes back in time to 1939... more on Wikipedia
12 and a Half Angry Men
"12 and a Half Angry Men" is the sixteenth episode of the eleventh season and the 204th... more on Wikipedia
Lois Kills Stewie
Presumed dead, Lois returns from the wilderness and names Stewie as her killer. On the look...
McStroke
Peter decides to grow a mustache, and after being mistaken for a fireman, ends up lending a... more on Wikipedia
Untitled Griffin Family History
"The Griffin Family History" is the 27th episode of the fourth season of the animated comedy... more on Wikipedia
Road to Rhode Island
Death Is a Bitch
When Peter tries to get out of paying a doctors bill by faking his own death, he is visited by... more on Wikipedia
Peter retells the story of Star Wars in this hour-long episode of Family Guy. When Princess... more on Wikipedia
Road to the North Pole
Stewie's favorite thing after his teddy bear, Rupert, is Christmas. So when he hears that... more on Wikipedia
Petergeist
Peter wants to top Joe, who just built a new home theater system, so he starts to build a... more on Wikipedia
To Live and Die in Dixie
Chris chooses a robber out of a lineup, but after Peter accidentally tells the robber where... more on Wikipedia
I Dream of Jesus
When Peter re-discovers his love for the painfully annoying yet seductively catchy tune... more on Wikipedia
Road to Europe
Stewie is addicted to the British hot children's show "Jolly Farm Review" based on Mother... more on Wikipedia
The Courtship of Stewie's Father
Lois thinks Stewie is trying to kill her due to his lack of quality time with his father, so... more on Wikipedia
Peter makes good on another power outage at home--by entertaining his family with a retelling... more on Wikipedia
E. Peterbus Unum
"E. Peterbus Unum" is the 18th episode from the second season of the FOX animated series... more on Wikipedia
Meet the Quagmires
Death grants Peter's wish to go back in time to 1984 when he was 18, but only for one night.... more on Wikipedia
Baby Not On Board
Peter gets a lasting supply of gasoline for the year, so the family decides to use it to take... more on Wikipedia
Da Boom
"Da Boom" is the third episode of the second season of the animated comedy series Family Guy... more on Wikipedia
Family GuyEntertainment
Top 10 Current Queries in TV Episodes: nipsey hussle status symbol 2anime girl motorcycleGilmore Girls referencesrock opera examplesellen snyder when will she be releasedsongs with must in the title49ers middle linebackersong name by soundtoaster strudel flavorsshameless season 2 cast


Charles are garnered over thirty years of preaching the Word, teaching sound doctrine, counseling, and leadership mentoring. Pastor, a self-published author and founder of Jump Start Recovery - helping the forced homeless ignite faith in Christ and recover life.
The Making of a Midnight Cry Messenger.
Enduring Tribulation to become Rapture Ready.
Ministry to the Homeless and those in Crisis.
Speaking Agreement: I require that my travel, lodging, and meal expenses are covered in advance. To be refunded if there is a cancellation. I ask that a offering to be taken up during each meeting to be equally shared with the sponsoring ministry or fellowship, and that my portion of any offerings be donated to our Jump Start Recovery Ministry to the homeless.


text:
Press Releases and Bulletins
Procedures/Treatments
Early Life Exposures Impact the Odds of an Endometriosis Diagnosis
Author: ASRM
Origin: ASRM Press Release
HIGHLIGHTS FROM THE AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE'S 2019 SCIENTIFIC CONGRESS & EXPO
Note: Press room (PCC 203A) open Sun. October 13, 2pm-5pm EDT; Mon. October 14-Wed. October 16 8:00am-5:30pm EDT.
Philadelphia, PA- New results from The Women's Health Study: From Adolescence to Adulthood (A2A) presented at ASRM's 75th annual Scientific Congress and Expo reveal that in addition to having a hereditary component, the odds a young woman will be diagnosed with endometriosis are influenced by early life exposures, like whether or not she was breastfed or if her parents smoked during pregnancy or around their children.
The nested case control study included 604 young women within the A2A: 295 with laparoscopically-confirmed endometriosis and 309 controls. All participants were under 25 years of age at enrollment; controls averaged 22 years old and subjects with endometriosis were an average age of 17 when they joined the study.
Participants completed a questionnaire on early life health factors including mother's age at delivery; birthweight; length of gestation; parents' smoking habits during pregnancy, infancy, and childhood; and whether or not the subject was breastfed.
The average age at menarche was 12 for both subjects with endometriosis and controls. The mothers of 50% of the women with endometriosis also suffered from endometriosis, while only 9% of the controls reported that their mothers had endometriosis.
Participants who were breastfed had about one third the odds of diagnosis with endometriosis under the age of 25 as those who had not been breastfed. Although the number of women exposed was small, the impact of parental smoking was dramatic. Young women whose parents smoked during their childhood were 2.5 times more likely to be diagnosed with endometriosis and those whose mothers smoked while pregnant with them were four times more likely to receive an endometriosis diagnosis.
ASRM Vice President Hugh Taylor, MD, noted, "Research like this into potential causes of endometriosis is extremely valuable. Identifying modifiable risk factors, like parental smoking, and taking action on them can help reduce the impact of this painful and debilitating condition."
P-525 Sasamoto et al, "In Utero and Early Life Exposures in Relation to Odds of Endometriosis in Adolescents and Young Adults"
ASRM is a multidisciplinary organization dedicated to the advancement of the science and practice of reproductive medicine. The Society accomplishes its mission through the pursuit of excellence in education and research and through advocacy on behalf of patients, physicians, and affiliated health care providers. The Society is committed to facilitating and sponsoring educational activities for the lay public and continuing medical education activities for professionals who are engaged in the practice of and research in reproductive medicine. www.asrm.org
For more information on these press releases, contact:
J. Benjamin Younger Office of Public Affairs
409 12th Street SW, Suite 602
Sean Tipton
Ph: 202-863-2494 or 202-421-5112 (mobile)
Email: stipton@asrm.org


text:
Q: Combine two ImageMagick codes in a Script from Linux Thanks to different forums, I could solve two issues separately:

*

*The first was to blend, resize and position two images.

*The second was to place the filename in the middle.

Taking the images of the first link, I tried to combine both codes.
What I want is to run both codes automatically.
Concerning the text, the code must identify properly the filename of the background image and place in the middle. Sometimes, the filename is so large that does not fit the area, so it must be written in two lines. There must be a white background with 75% of opacity in the text, going some pixels at the top-bottom-left-right margins of the text.
The order of the the script is:

*

*Blend the logo to the southwest area of the fractal image.

*Place the name of the fractal in the middle of the previous combination.

I tried different ways, but I copy/paste here both independent codes. The one concerning the text should fulfill the requirements said previously.
convert 1.png \( 2.png -resize 60% -gravity west -chop 80x0 \) -gravity southwest -define compose:args=75 -compose blend -composite 1_2_b.png

filename=`convert "2.png" -ping -format "%t" info:`
convert "2.png" -fill black -undercolor white \
-gravity center -pointsize 30 -annotate +0+0 "$filename" \
 lena_label.jpg

A: You can do that as follows in ImageMagick 6.
convert 1.png -set option:f "%f" \( 2.png -resize 50% \) \
-gravity southwest -define compose:args=75 -compose blend -composite \
-undercolor white -fill black -gravity south -font arial -pointsize 18 \
-annotate +0+0 "%[f]" 1_2.png

For ImageMagick 7, replace convert with magick.

redpajama_set_name: RedPajamaStackExchange


Attorneys for a Christian mother of five sentenced to death by hanging for allegedly speaking ill of Muhammad, the prophet of Islam, have filed an appeal of the verdict, they said.
The women told Muslim cleric Muhammad Salim about the June 14 incident, and he filed a case with police on June 19, 2009, according to police. On that day (June 19), Masih said, the Muslim women suddenly raised a commotion, accusing Noreen of defaming Muhammad.
Chaudhary also fined her 100,000 rupees (US$1,150), according to the Centre for Legal Aid Assistance and Settlement (CLAAS).
verdicts in blasphemy cases are usually overturned by higher courts. He said lower court proceedings take place under intense pressure, with local Muslims gathering outside and chanting slogans to pressure judges. Saman added that NCJP research showed that up to 80 percent of blasphemy charges are filed against people to settle personal scores.


Welcome to the official website of the No. 1 Ladies' Opera Festival!
Next April, we will launch an opera festival in the heart of Botswana. There will be concerts, workshops, and performance events. And we'll get it all on film! Feel free to explore our site to learn more about this exciting project.
Thank you, Carrie! Check back when you can for more cool details!


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Colorado's "most versatile artist" Douglas Rouse continues to reinvent himself for any occasion. He has proven his artistic abilities, creativity and reliability to companies and individuals worldwide. He is available for hire, anywhere in the world, as a Speed Painter, 3D Chalk Artist, Muralist and Contemporary Artist for works on canvas. Douglas is beginning in 2019 a 52 Mural in 24 month campaign. A mural in each of the 50 states and 2 international. Thank you for your possible interest.
This is an example of TROMPE L'OEIL.


text:
The Best Schools in Auckland 2013
By Simon Wilson date Nov 12, 2013
The life and culture of the place, the ability to hold on to students – how do you measure the quality of a school, and how do you work out how well it will serve your child? We've been talking to principals, teachers and students, reading the reports and crunching the numbers.
Also on metromag.co.nz, The Best Schools in Auckland 2014, featuring the most recent available achievement data.
Every morning, not so long ago at a school in South Auckland, principal David Hodge and his deputies rostered themselves, two by two, to stand at the gates and greet every student as they arrived. By name. They weren't doing it to guard the school. They were doing it to reinforce a culture of communication and care. And it wasn't just about the kids: "We knew the kids, and we knew their families," says Hodge. "We'd ask after them, 'How's that new puppy?' and 'Is your mum's cold better?'"
So the kids came to school knowing they were part of something big and inclusive, and that the men and women who ran the school — who were important role models for those kids — cared about each one of them.
This in itself did not make it a good school or guarantee good grades for the students. But it did create an environment where teaching and learning would be easier. When the culture of the school is based on its relationship not just with the students but with their whole families, that's a strong platform for achievement.
Hodge has moved on now, swapping those few hundred low-decile students for a few thousand high-decile ones at Rangitoto College, the largest school in New Zealand. He can't know them all by name, and he certainly can't greet them all every morning. So integration with families takes other forms: getting the students involved in some of the enormous wealth of extracurricular options, for example, in which parents can also become engaged.
Catholic schools know all about a commitment to families, although it is not usually the first thing they point to when asked about their success. Their levels of academic achievement are almost universally higher than those in other comparable schools, and they like to tell you the reason is their religion.
Chris Rooney, principal of Liston College, a decile 5 Catholic school in Henderson, says quite fervently his school does well because it is dedicated to making the most of every student's "God-given abilities".
Brian Evans told me it was "the faith" a few years ago, when he was principal of De La Salle College, a decile 1 Catholic school in Mangere East. His students were achieving way above the norm. But a couple of years ago, Evans moved to Kelston Boys High, a state school, where his students are now also recording some startlingly good grades.
Clearly, it's not just the faith. Malaea Evile, a student at Marcellin College, a co-ed decile 3 Catholic school in Royal Oak, told us something revealing: "My mum is ambitious for her children," she said. "The teachers smile when they see her coming with her notebook. She demands excellent effort, homework and achievement. So she records every bit of advice from parent-teacher evenings and repeats it to me and my sister for months."
Parent-teacher evenings as the cornerstone of a family/school/student plan for progress? And how it's monitored? Now there's some revolutionary thinking.
Every parent knows how desperately farcical those parent-teacher evenings can be, when we shuffle dutifully from pillar to post, queueing in the corridors in the glumly remote hope the next five-minute interview might reveal something useful. Wondering if all the families not represented at all on such evenings are making things worse in the school, or are they the only smart ones?
It shouldn't be like that. If a school tells you that's the best they can do, they really don't understand one of the basics of modern education.
So what do Catholic schools have over many other schools? Perhaps it's not so much the faith itself, as the mechanism that faith provides for the schools to integrate into the lives of their families. They share not just their religion but so many of the significant events of their lives — cultural, social, sporting, celebratory, commemorative. The things that give shape to who they are.
For other schools, doing all that in other ways can be much harder. And that raises the first of our big questions. All schools love to talk about their "community", so when you're out there choosing, ask them about that community.
What is it you will belong to? Ask them: How are we — school and family — going to share in the frequently frustrating, occasionally shocking, often entertaining and deeply rewarding (you hope) process of helping your anxious newbie adolescents become fine young adults?
How Good are the Teachers?
What's the biggest influence on success in school? The quality of the teachers. Which means looking for a good school is about looking for a school with good recruitment policies, good professional expectations for its staff and a good record of retention.
But what does good even mean? It hasn't got much to do with personal style. Old-fashioned non-nonsense types are just as likely as down-with-the-kids young thrusters to be good teachers, or bad ones.
It's a handy question to ask a principal, though: what do they look for in a teacher? As some American studies have suggested, a key predictor of teacher quality is past performance. If a prospective teacher has a record of academic success and of running something successfully, they'll probably have a valuable aptitude for the job. Wanting to teach and being happy with their lives as teachers are also important, and so is perseverance.
Ask the principal, do they ask their teachers if they are enjoying their work? And if they're not, do they help them find something else to do?
Ask how many inspirational teachers your child will have over five years in the school. Ask what's expected of teachers in their own development. Post-graduate study? Regular upgrades for their teaching skills? Professional activity away from the school? Good schools have programmes of such things for their staff.
What do schools do to keep their best teachers? Private schools can offer whatever incentives their resources allow, but state schools are tied to nationally established pay scales. Some state schools get around this with trust funds that allow teachers to be paid for "extra activities", take "sabbaticals" and the like.
For many teachers, though, the issue isn't just money. It's also a question of opportunity. So how does the school help good teachers to advance?
Often, the best judges of teachers are the students. They know who gets them doing the business. The website ratemyteachers.com provides insights on this, although it's susceptible to peer pressure and not as good as talking to students directly.
Can they Explain Themselves to you?
Teachers — well, the entire education industry, really — love jargon. They call what they do "pedagogy". They use "formative assessment" if they're good, and rely entirely on "summative assessment" if they're not. They can, if you let them, go on and on about it.
You might not want to hear that stuff, but unfortunately many teachers are not good at using their words to explain themselves in simple language. Ask them to try. See if they can walk you through a typical lesson, tell you why it happens the way it does, and make it sound interesting.
What you're looking for is this. At the start, they will set out in writing the goals for the lesson. Throughout, there will be a two-way engagement: the teacher will give students feedback on an individual basis, and they will give the teacher feedback too. The lesson may well be based on the outcome of a recent test, and if there is to be another test, the results of that will be used to plan the next round of teaching.
In simple terms, this is the widely accepted best method, or pedagogy, of teaching. A "formative" approach emphasises the two-way nature of learning, where teachers must be attuned to student needs and ready to modify what they do, as they go. It also emphasises the diagnostic role of testing.
The alternative, put crudely, is to teach a bunch of stuff, have a test at the end, and then move on to something else.
One of the fundamental reasons most teachers dislike league tables and the prevailing emphasis on pass rates in end-of-year exams is that they can easily push classroom practice towards summative learning. As long as the students know what they need to know on the day of the exam, that's all that matters. Getting an A on a report becomes more valuable than whatever comments the teacher might provide.
Of course, good teachers and good schools will help their students to achieve beyond their own expectations, and end-of-year grades are the ultimate measure of that. So there has to be a balance. Ask about that. A good teacher should have some pretty interesting things to say about all this.
Next page: More on how to pick a secondary school, including academic options and the 'life of the school'
The success story of Catholic schools in Auckland
by Aimee Cronin
Metro's Best Schools in Auckland 2019: How to pick the right school
Macleans College cancels graduation dinner after students throw boozy before-school parties
The place of technology in New Zealand's classrooms
Young & restless: The new generation of high school activists
Going above and beyond: A genuine holistic education at Kristin
Read this before you send your child to boarding school
by Alex Blackwood


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Local lad, James Masters started his soccer career with Balgownie Public School before joining Australia's oldest soccer club, Balgownie Rangers. Slight of build and a master strategist, Masters went on to play for Australia in 22 international games and captained the team on 5 occasions taking on the likes of China, New Zealand, Canada and Czechoslovakia, during the 1920s.
After enlisting for active service in WW1, Masters also played club games for Newtown and Granville whilst stationed at Liverpool awaiting departure to the front. He played an impressive 401 club games scoring 351 goals. In all his time on the field, he was never once cautioned.
James was a stretcher bearer and bandsman during his active service and at the end of the war, he led an AIF soccer team formed in France in 1918.
During his war service, James met an English girl Annie Barraclough and at the completion of the war, he brought her back to Balgownie where they married and raised two daughters, their only son having died as an infant.
When not playing the beautiful game, James was a miner at Corrimal coal mine, executive officer of the South Coast Soccer Association and Master of the Balgownie Band. He had a life long association with the Balgownie Rangers Football Club, as player, executive and coach.
His achievements both on and off the field were posthumously acknowledged when the Balgownie village green soccer and cricket field were named in his honour along with the front gates of his local public school.
Both respected and loved by all, James 'Judy' Master was certainly one of Australia's great soccer players, and a true gentleman.
You can learn more about James 'Judy' Masters here.


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Jamie Shaw (born 11 June 1990) is a Canadian scientonomists and philosopher of science..
Barseghyan and Shaw (2017): Barseghyan, Hakob and Shaw, Jamie. (2017) How Can a Taxonomy of Stances Help Clarify Classical Debates on Scientific Change? Philosophies 2 (4), 24. Retrieved from http://www.mdpi.com/2409-9287/2/4/24.
This page was last modified on 28 September 2018, at 16:01.


SAN BERNARDINO, Calif. - After reviewing video circulating on social media that shows a brutal arrest conducted by two sheriff's deputies in San Bernardino, officials have asked members of the public who witnessed the incident to come forward.
Authorities are concerned with the actions of one of the deputies in particular who is seen in the cellphone video repeatedly kicking the suspect in the head after the man was handcuffed and his body limp, according to KTLA.
The arrest occurred last Friday around 1 a.m., and investigators are hoping to interview motorists who were in the area at that time, the San Bernardino County Sheriff's Department said in a statement.
The one-minute clip opens as one deputy has 21-year-old Gerardo Bernabe Vasquez pinned to the ground, with Vasquez's legs squirming.
Moments later, a second deputy arrives on the scene. As the second deputy begins to arrange Vasquez's hands to cuff them, the first deputy punches Vasquez twice in the head.
After Vasquez is handcuffed, the deputies each pick up one of his arms as they attempt to load him into a patrol vehicle. But Vasquez's body has gone limp, his torso and legs flopping toward the ground as his arms are raised behind his back.
The deputies drop him, and it is then that the first deputy begins to kick his face. It appears he strikes him three times, stepping on his head in the final blow.
Vasquez was eventually booked on suspicion of resisting or obstruction an officer, was cited and later released, the Sheriff's Department said. It was unclear why or how the two parties initiated contact.
The deputy seen striking Vasquez was placed on paid administrative leave, pending the results of the probe. Authorities said they would not identify the deputy while the investigation is ongoing.
Sheriff's officials said they were already investigating the incident when the video gained attention on social media, and Sheriff John McMahon said he found the "level of force" seen in the video concerning.


New item at Step 2 - An additional traffic management item has been added at Step 2 allowing users the ability to create more detailed plans.
Signage Icon Improvements - Users with access to the signage app will notice significant improvements to the way signs are placed on the map, moved and deleted. Enhancing the ability to place signage items closer together without causing conflict with other signs already on the map.While deleting signs has been upgraded to a click and drop feature which allows users complete control over the actions they complete with their signage.
CSV Output enhancement - Permit status has been included into the CSV output.For more information about the Roadworks Report App please contact your account manager for more information.


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Get Up Dates Daily > Blog > Automotive > 2023 Subaru Ascent Coming This Fall
2023 Subaru Ascent Coming This Fall
Automotive 85 Views Posted by Jared Kiss June 17, 2022
2024 Honda MDX All-Electric Variant Coming
The new 2023 Subaru Ascent is about to receive a facelift that will bring a more modern grille design and revised lighting elements. On top of that, the interior is refreshed as well and the three-row SUV now comes standard with a large 11.6-inch touchscreen that supports wireless Apple CarPlay and Android Auto.
We also heard that Subaru would make EyeSight driver-assistance tech richer this year, which includes a new automated evasive steering feature. Just like its predecessor, the forthcoming Ascent will come with the same engine. Under the hood is a 2.4-liter turbo flat-4 capable of producing 260 horsepower and 277 lb-ft of torque.
Will the 2023 Subaru Ascent Be Redesigned?
Design for the 2023 Subaru Ascent is more attractive thanks to an updated appearance. The new SUV now comes with a larger grille, headlights that are reshaped, and the updated front bumper.
Subaru also reveals that they improved aerodynamics, which should result in better fuel economy. The rear is also redesigned, and we noticed new taillights that are now shaped like the letter C.
Interior Upgrades
The cabin of the 2023 Subaru Ascent is roomy and comfortable. Still, the third row is a bit tight but is ideal for small children. Interior design and quality are on a higher level, and you'll find a softer touch material. Every Ascent comes with a vertically oriented 11.6-inch touchscreen that replaces the aging 6.5-inch and optional 8.0-inch displays.
The new interface also supports wireless Apple CarPlay and Android Auto. The black-trimmed Onyx Edition is the best option if you're looking for something unique. This model has green contrast stitching inside, standard panoramic sunroof, and more. We must also mention that the Ascent also comes with the improved driver assists. Subaru says it now can recognize cyclists and pedestrians sooner at low speed. Likewise, it comes as standard with a blind-spot monitoring and rear cross-traffic alert also called Automatic Emergency Steering.
2023 Subaru Ascent Engine Specification
As we said, the 2023 Subaru Ascent will deploy the same powertrain from its predecessor. This means we can expect a potent 2.4-liter turbocharged flat-4 capable of making 260 horsepower and 277 lb-ft of torque.
The engine uses a CVT automatic transmission and 8-speed manual mode. According to Subaru, maximum towing of the new Ascent is 5,000 pounds. It is also worth noting that the new SUV also has standard all-wheel drive as well as trailer stability assist.
2023 Subaru Ascent Price, Release Date
The pricing for the 2023 Subaru Ascent will be reportedly slightly higher compared to the outgoing model. The base model starts at $33,295, which is around $1000 more. However, the mid-range Premium trim is $35,795 for the model with 8-passenger, or $37,255 if you go for a second-row captain's chairs.
Finally, the range-topping Touring model, which includes all that you need, starts at $46,445. We expect the new SUV to debut in the coming months with a slightly revised exterior and interior. As before, the closest competitor in the family-friendly 3-row crossovers class is the Nissan Pathfinder.
Jared Kiss June 17, 2022
Previous Article Richard W McIver Killed in Vehicle Crash on Highway 118 [Moorpark, CA]
Next Article Your Daily Horoscope: June 17, 2022
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Posted by Jared Kiss December 28, 2022


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There was a moment in time where I wasn't buying a ton of beauty products. I had taken a massive break after being consumed by my collection and I knew I didn't need any more items. I also was less than impressed with whatever was happening in the industry.
However, with the end of winter and the start of new seasons, my love of beauty has been reinstated. Maybe it's because the warm weather brings new and innovative products; everything from hair lighteners to SPF hybrids. It excites me and instills something new in me.
There are so many beauty products I want to try and that's a post for another time but right now, there are so many new beauty products I'm loving and simply cannot stop using.
1. Ouai Sun of a Beach Spray: Something came over me when I saw this product being teased on Ouai's Instagram. I don't know if it was the 11-year-old inside me that desperately wanted blonde highlights or if I was drawn in by the name and packaging. Either way, I scooped it up and have been loving it. I've used this a handful of times, spraying in my hair after a shower, and it smells like a beautiful beach. Is it doing anything for my hair? No, but I love it anyway. Maybe once I sit in the sun (if it ever gets warm in NYC) it'll make a difference to my dark locks.
2. Milk Watermelon Brightening Serum: This was another product I bought on launch day and I have never looked back. My skin is pretty decent but I deal with a lot of discoloration and dullness. Sometimes it looks like my skin is lacking and I just need something to oomf it up. That's this serum! I love the fact that it's a solid serum and it absorbs into your skin super fast so there is no greasy mess to deal with. It's also one of the few beauty products that I notice an immediate difference with; I wake up the next morning and my skin is a little brighter and looks a little evener. It's magic!
3. Trader Joe's Rose Oil: I have a new obsession with Trader Joe's and a continuing obsession with rose scented items. Those two loves have combined to give me this delightful oil. It's not too heavy, sinks into the skin immediately and smells pretty damn good. I don't notice a huge difference but I feel very pampered when I use it -- it's a nice little pick me up and is a lightweight moisturizer for the warm months.
4. Drunk Elephant Baby Facial: My curiosity about Drunk Elephant products is growing by the day and I owe it to the magic Baby Facial. I've never gotten a facial before but using this once a week (or even once every two weeks) has made a huge difference in my skin. The texture has disappeared and discoloration has faded -- this is magic in a bottle and there is a reason it has a cult following. DE is the real deal and Baby Facial is something everyone should have in their skincare routine.
5. Benefit Roller Lash: This is an oldie but a goodie. I've been using Laura Geller LashBOSS for a while but wanted something different. I picked up Roller Lash after using a sample I had and haven't looked back. I've gone through a handful of these in the past few years but rediscovering it was heaven. It has a really unique brush, the perfect wet/dry formula and is truly my favorite mascara of all time.
6. Laura Mercier Flawless Fusion Concealer: If you've been reading the blog for a while, you know how much I love concealers. I was itching for a new one a few months ago and bought the newest Laura Mercier one. It took me a few tries to really like it because I think I got the wrong shade, but now I'm in love and haven't touched Shape Tape in weeks. It's the perfect medium coverage and blends out like a dream. It's not super tacky but is long wearing; it's really everything you could want from a liquid concealer.


Airbnb has revolutionised the way we travel but has also created a whole new class of budding entrepreneurs; the so-called rentrepreneurs. These are ambitious property owners who have decided to top their incomes up by renting out anything from spare rooms in their houses or flats, to an entire house or any number of other spaces from caravans and yurts to wooden shacks deep in the wilderness.
The success of Airbnb is one of several disruptive technologies that have taken the internet by storm. It's not surprising then that this brave new world comes with a lot of questions, whether about being a good host or how to get the best out of the guest experience.
How do I list my property on Airbnb?
It's quite straightforward to sign up for an Airbnb account and then add a listing by clicking the "List My Space" button. You can upload pictures, add information about your listing and its location and choose whether to accept instant bookings or whether you prefer to vet guests by going through the booking request procedure. Once your listing is live, make sure you keep it up to date and respond to any queries as quickly as possible as fast response times boost your ranking.
Airbnb collects payment on your behalf and strongly discourages direct cash payments. Money is held for 24 hours after check in at which point payment is transferred directly to your bank, minus Airbnb's 3% fee, which is payable on every booking.
If you have a mortgage, then it's up to you to check the legality of listing your home on Airbnb with your lender. Many mortgage companies won't allow Airbnb lets (at least not without incurring fees), but there is evidence that the industry is adapting to the Airbnb market. If you rent your property then you will need to contact your landlord but be warned, most leases in the UK forbid subletting. If you own your home outright, check the Planning Portal for information on change of use.
Do I need to pay taxes on my Airbnb?
Under the UK Government's Rent a Room scheme you can earn up to £7,500 tax-free every year by letting out a room in your house. If your Airbnb listing earns you more than that amount then you will need to file a tax return with HMRC (although you can offset certain house expenses against your earnings).
How can I boost my listing?
Earning good reviews is the best way to boost your listings and there are plenty of ways you can do it that don't cost a fortune. A basket of fruit and good tea and coffee, a bottle of wine and fresh flowers can all welcome your guests. Provide the best quality bedding and towels you can afford and always leave nice toiletries in the bathroom, Information and recommendations for your area are always appreciated and you might even consider leading an Airbnb Experience locally.
Airbnb offers a Hosts Guarantee but it's worth reading the terms and conditions to see exactly what's covered. The best thing to do is to check your home insurance and talk to a specialist insurer to make sure your property is protected. Because Airbnb is a community built on trust, it pays to offer as complete a profile as possible and get verified as part of your hosting experience. Use the tools that Airbnb provides to vet your guests discreetly before accepting any bookings. You can also choose from one of five graded refund policies and use the Airbnb Resolution Centre to resolve any disputes in a timely manner.
Remember that when you book through Airbnb you're staying in someone's home, so the first thing to do before you view any listings is to complete your profile so your host knows a little bit about you. When you find a listing you like you can either book instantly or go through the booking approval process. You can pay using major credit and debit cards and services such as PayPal.
Should I communicate with my host outside Airbnb?
No, you shouldn't. The Airbnb community is designed to protect both hosts and guests, so make the most of profiles and verifications and the communication tools provided. Same goes for making payments - always pay through Airbnb and never offer your hosts cash.
Yes, you do. This is the host's way of protecting their property from damage. You'll also pay a 6-12% service fee when you make your booking and you may also be asked to pay a cleaning fee. All fees should be clearly explained when you book but you'll pay extra if you change your reservation.
Any tips for finding a good place to stay?
The first thing to do with any listing is to read it from start to finish so you know exactly what's on offer. Some hosts will even bury a code phrase in their listings so they know you've read it thoroughly. Then check out the reviews and your host's verifications and references. Get familiar with their cancellation policy too so you won't be in for any nasty surprises. Always use Airbnb for payments and communications and if something doesn't feel right, walk away from the booking.
Should I tip my host?
Tipping isn't necessary but gifts like wine, chocolate and cake are always appreciated and are certainly a very good way of getting a really great review from your host.
Communicate with your hosts as quickly as possible - nothing's worse than telling your hosts everything is fine and then giving them a poor review about an issue you didn't give them the chance to resolve. However, if there is a genuine problem - for example, your host asked for extra payments that weren't mentioned at the time of booking or the accommodation is unsafe or doesn't match up to the listing - use the Resolution Centre to settle the dispute.
Any hints on being a good guest?
An Airbnb rental isn't like a hotel - you're often staying in your host's home, so don't treat them like the concierge. Let them know if you're likely to miss your scheduled arrival if you're delayed and clean up after yourself by taking away any rubbish and stripping the bed. Always respect the power of the review as well; by all means, leave negative feedback if you've had a genuinely bad experience but don't blame your host if there's bad weather or you didn't like the city you were staying in, as these are things outside of their control.


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Posted inElection 2006
Edited: Waxing Nostalgic
by Christine Stuart August 8, 2007, 10:09 pm January 21, 2021, 5:44 pm
One year ago today, all the world watched as the results of the Democratic primary between U.S. Senator Joseph Lieberman and Ned Lamont rolled in.
A palpable sense that change is possible in America rang out in a Meriden hotel ballroom as a confetti- draped Lamont proclaimed victory. At Lieberman headquarters in Hartford it seemed at times that the media outnumbered the campaign staff and supporters, who returned from the polls apprehensive about what would happen.
Today, Lamont re-launched his web site with great enthusiasm from local blogs. Bloggers waxed nostalgic about the primary victory and wondered if those who propelled Lieberman back into office in the general election regretted their votes.
Connecticut bloggers are unique in that they stayed involved in politics, even when there was no Congressional candidate, like Lamont, to rally behind. And they seem poised to relive the Lamont-Lieberman battle through their coverage of local mayoral races.
Hartford's mayoral race has all the ingredients for a Lamont-Lieberman rematch.
A bunch of Democratic Hartford politicos like City Council Majority Leader rJo Winch and her mother, Prenzina Holloway, maintained their support for Lieberman even after his defeat in the Democratic primary. Hartford Mayor Eddie Perez said he supported the Democratic nominee after the primary, but the photo of Perez smiling and clapping with Lieberman's son after Lieberman lost the primary in August makes it hard to believe. Not to mention, Lieberman's campaign manager, Sherry Brown is the mother-in-law of Perez's Chief of Staff Matt Hennesy.
Perez has hired two former Lieberman staffers to run his re-election campaign against more than a handful of candidates seeking to unseat him.
According to campaign records, Perez 07 has paid former Lieberman staffers, Dan Gerstein and Ken Curran more than $20,000 each, since April. Curran is Perez's campaign manager and Gerstein is listed as a consultant.
Lamont has also thrown his hat into the Hartford political arena by donating to two mayoral candidates running against Perez. According to records, Lamont has given $250 to Thirman Milner, who has decided to forego the Democratic primary on Sept. 11 and run as an Independent in the general election, and $250 to state Rep. Art Feltman, who has petitioned to get on the Novemeber ballot, in case he loses the Sept. primary.
Like his challengers, Perez will petition to get on the ballot in November.
Two more Democratic mayoral candidates, I. Charles Mathews and state Rep. Minnie Gonzalez, will petition to get on the November ballot.


text:
Monse Teams Up With Equinox for Capsule Collection
HOSIERY'S NEW CENTER STAGE AT DANSKIN
HOSIERY'S NEW CENTER STAGE AT DANSKIN
Byline: Marc Karimzadeh
NEW YORK -- Danskin's got some ideas in...
March 5, 2001, 12:00am
NEW YORK — Danskin's got some ideas in store.
Beaming with confidence that legwear will fully turn around this fall, the company that owns Pennaco hosiery has chosen to present its legwear at the center of the showroom, laid out like a store department.
"We feel so strongly that it is hosiery's time again," said Carol Hochman, Danskin's president and chief executive officer. "We wanted to show the stores what [we feel] they need to do to get the customer excited."
The result is a clean and graphically organized space with separate fixturing for its Ellen Tracy, Round The Clock and Givenchy brands. There are also selected fashion items of those collections displayed on leg forms placed on side tables.
This is a departure for the company. Before the restructuring of the showroom, samples were put on a large, central table and accompanied by some leg forms here and there. For this fall market, fashion items feature more prominently than before to underscore that fashion will be one of the main driving forces in the category's future and show how they can make legwear departments more attractive to consumers.
"The business had become so commodity driven with basic pantyhose women only buy when they really have to. Now, we are giving them something different," said Barry Tartarkin, Pennaco's vice president and general manager.
For fall, the company's offering includes a variety of textures and specialty items, such as Givenchy's plaid and argyle knee-highs or styles adorned with Swarovski crystals. "Magazines are still showing much legwear, so let's replicate that with an extensive fashion offering in the departments," Hochman said, pointing to another accessories classification that has seen a similar revival in the past five years. "Handbags used to all be black and brown leather but that's not what the business is about anymore."


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Nevertheless, a few hardy entrepreneurs and venture capitalists continue to found and fund start-ups, whose goal is to discover and develop truly innovative classes of drugs for obesity and metabolic disease.
A November 3, 2010 Xconomy article focused on the Cambridge, MA startup biotech firm Energesis Pharmaceuticals. Energesis was confounded by Olivier Boss, PhD (formerly of Sirtris Pharmaceuticals), Brian Freeman, MD (former Venture Partner at GreatPoint Ventures), and Jean-Paul Giacobino, MD (Professor Emeritus, University of Geneva Medical School, Switzerland). Dr. Boss serves as Energesis' Chief Scientific Officer, and Dr. Freeman as its Chief Operating Officer.
Energesis focuses on the discovery and development of drugs for the treatment of obesity, diabetes, and related metabolic diseases. The company plans to develop therapeutics that work by increasing energy expenditure, rather than the usual approaches of decreasing appetite or blocking absorption of fat in the gut. Energesis researchers intend to discover and develop drugs that increase the amount and/or activity of brown adipose tissue (BAT) to combat obesity and other metabolic diseases. BAT is a type of mitochondria-rich adipose tissue that burns fat and dissipates the energy as heat rather than storing it. The mitochondrial protein UCP1 (uncoupling protein 1) is the key biomolecule that makes this process possible. BAT has long been known to be central to non-shivering thermogenesis in rodents, for example to maintain body temperature when they are exposed to cold.
Until recently, researchers believed that in humans, significant populations of BAT cells were found only in infants. However, in recent years researchers found that adult humans possess reservoirs of brown fat in the neck region and other areas of the upper body as well as in skeletal muscle. (See the figure above.) Adult human BAT can be stimulated by acute exposure to cold and via the sympathetic nervous system, and by various pharmacological agents. Energesis' drug discovery technology is based on the use of brown fat stem cells. The company has provided few details on its technology in published sources.
In October 2010, Energesis was named as one of the winners of the 2010 MassChallenge Global Startup Competition, where it was the top life sciences company. In that competition, Energesis was also one of the top 111 entrants that were invited to participate in a 3-month accelerator program. This provided intensive mentoring, and access to such resources as office space, legal counsel, and introductions to funding sources. Energesis, which has temporary office space in the Cambridge MA incubator Dogpatch Labs (created by venture capital firm Polaris Ventures), is now seeking additional seed-stage funding.
Brian Freeman is key to Energesis' financing strategy. As a Venture Partner at GreatPoint Ventures, Dr. Freeman cofounded another Cambridge MA company that focuses on obesity, Zafgen. Zafgen was founded in 2005. We discussed Zafgen briefly in an earlier blog post. Zafgen's drug discovery and development profile is based on targeting the vasculature of adipose tissue, similarly to targeting tumor angiogenesis. Zafgen already has a compound, ZGN-433 (which is a methionine aminopeptidase inhibitor), in Phase I development, and is working on earlier-stage compounds. Thus, like Energesis, Zafgen targets a novel weight-control mechanism that does not involve appetite control in the CNS or fat absorption in the gut.
Zafgen has venture funding not only from GreatPoint, but also from Atlas Ventures and Third Rock Ventures. It was named as one of the "Fierce 15" leading biotechnology companies of 2009 by FierceBiotech.
Meanwhile, another Cambridge MA biotech company, Acceleron Pharma, discovered a compound, ACE-435, which targets BAT. ACE-435 inhibits signaling of members of the TGF-beta protein superfamily. in preclinical studies in obese animals, ACE-435 increased brown fat, decreased white fat, increased skeletal muscle, and dramatically lowered serum cholesterol and triglyceride levels. Acceleron is developing ACE-435 for treatment of metabolic diseases. The company was named as one of the "Fierce 15" biotech companies in 2010.
Acceleron, which was founded in 2004 and has three products in the clinic, has raised three rounds of venture capital, and has a major corporate alliance with Celgene. In September 2010, it also signed a $498 million agreement with Shire to develop muscular dystrophy drugs. Acceleron is thus a more mature company than Zafgen or Energesis. Unlike Zafgen and Energesis, Acceleron works in several therapeutic areas, not just obesity and metabolic diseases.
The entrepreneurs who founded obesity specialists Zafgen and Energesis–as well as the venture capitalists who funded Zafgen, and the executives and researchers at Acceleron who have been developing ACE-435–are working on obesity drug development despite the pall of gloom caused by the failures of nearly every antiobesity drug, and the increasing currency among leaders of health insurance companies and health care providers of the old idea that obesity is entirely the fault of the obese, due to "lack of personal responsibility" or "food addiction". This is despite the abundant evidence that obesity is a complex disease with a large genetic component. Health care leaders, as well as obese people themselves, are frustrated with the lack of solutions to the growing obesity problem, and thus may be tempted to fall back on old, discredited explanations.
The entrepreneurs, researchers, and venture capitalists behind Energesis, Zafgen, and Accleron, however, see the failure of most antiobesity drugs as an opportunity. The failed drugs target common neurotransmitter receptors in the CNS, and thus would be expected to have serious adverse effects, since these receptors are involved in multiple physiological processes in the CNS and elsewhere in the body. Drugs that target physiological pathways other than appetite control in the CNS, and which are based on superior biology-driven drug discovery strategies, may avoid the safety problems of the CNS-acting drugs, as well as exhibiting much greater efficacy. Such drugs may fulfill the major unmet medical need in the obesity area, where there are currently no good solutions.
The founding of Zafgen and Energesis also flies in the face of the current negative situation in the venture capital and credit markets, and in the economy in general. Small companies (especially including startups) continue to find it difficult to raise cash. More established biotech companies, as well as pharmaceutical companies, also feel the need to cut budgets and especially to cut their workforces to save cash. In the Boston area, Big Biotechs Genzyme (which has been facing a hostile takeover from Sanofi Aventis, and which is in discussions to sell itself to Takeda) and Biogen Idec have slashed workforces and budgets, as has contract research firm and animal model supplier Charles River Laboratories. Acceleron also cut its workforce in November 2010.
Nevertheless, both Acceleron and Zafgen (the latter under the leadership of Brian Freeman) have managed to raise significant amounts of venture capital in this tough market. In the case of Zafgen, this is despite the generally gloomy prospects for antiobesity drugs, which are its dedicated focus. We hope that Energesis, in Dr. Freeman's capable hands, will also be able to bring in Series A venture funding.
The type of entrepreneurial innovation shown by Energesis, Zafgen, and Acceleron has implications beyond the obesity area. In a recent speech, the CEO of Lilly, John C. Lechleiter, Ph.D. outlined the components of an environment that supports medical innovation. (We citied Dr. Lechleiter's speech in an earlier blog post on the obesity drug market.) Among these components is what Dr. Lechleiter called "a larger 'ecosystem' that allows innovation to flourish". Such an ecosystem would include an "atmosphere" that allows innovation to thrive, "nutrients" in the form of monetary investments, and the "seeds" of human talent in relevant scientific disciplines.
The development of Zafgen and Energesis illustrates the importance of the Boston area biotech and pharmaceutical innovation hub in fostering the initiation and growth of biotech companies with innovative strategies that are potentially game-changing, by providing such an ecosystem. This has included entrepreneurial researchers with innovative ideas and intellectual property, lead venture capitalists willing to back their ideas (and, as in the case of Brian Freeman, to leave their venture capital firms and to join with the researchers in a start-up), universities such as Harvard, MIT, Tufts, and Boston University, the large numbers of biotech companies, both large and small, in greater Boston, the presence of Big Pharma facilities including Novartis' R&D world headquarters, incubators such as Dogpatch Labs, and entrepreneurship competitions such as the MassChallenge and the MIT Enterprise Forum's 100K competition.
The United States has other biotech/pharma innovation hubs as well, most notably the San Francisco Bay area and greater San Diego. As shown by the example of ZymoGenetics (see our November 11, 2010 blog post), Greater Seattle has been such an innovation hub, although biotech leaders in Seattle are afraid that their hub has been eroded by acquisitions such as that of ZymoGenetics by Bristol-Myers Squibb and the earlier Amgen-Immunex merger, with the resulting substantial layoffs. Other major U.S. biotech/pharma hubs include the Research Triangle Park area of North Carolina and greater New York/New Jersey/Philadelphia. Canada and several Western European countries also have biotech/pharma innovation hubs.
Various other cities and states in the U.S., as well as cities and countries in Europe and South and East Asia, are working to build new biotech hubs to bolster their economies. Big Pharma companies, with their massive need to acquire or partner for new, innovative drugs, must also develop strategies to foster ecosystems for innovation, both within their own organizations and in seedbeds for potential partners such as existing and emerging biotech hubs. The example of the role of the greater Boston area in spawning such companies as Energesis, Zafgen, Acceleron, and several others that have been covered in this blog may provide case studies to help Big Pharmas in formulating new strategies to foster innovation.
As the producers of this blog, and as consultants to the biotechnology and pharmaceutical industry, Haberman Associates would like to hear from you. If you are in a biotech or pharmaceutical company, and would like a 15-20-minute, no-obligation telephone discussion of issues raised by this or other blog articles, or of other issues that are important to your company, please contact us. We also welcome your comments on this or any other article on this blog.


A miniature wiener dog has returned to his home in Southern Minnesota three weeks after he disappeared.
According to KARE-11 News, The Norwood Young America couple, Matt and Mandi Rademacher, have three dogs, which includes the long-haired dachshund Oliver. It all started on Christmas Eve as the Rademachers let Oliver outside to do his thing. A loud noise scared him off.
As the days passed there was still no sign of Oliver. The Rademachers even left out his kennel on their porch with blankets inside of it, along with his favorite toys in hopes to lure the lost pooch back.
It was about three weeks later as Matt was letting one of their other dogs out in the morning that something scared the dog. It was Oliver. Matt Rademacher told KARE-11 that during the time Oliver was missing the temps "got down to -15 a couple nights, really, really cold snaps and one night it even rained. It's like, well he's a long-hair. If he gets wet and it's that cold, what are the odds of him surviving?"
Other than a wound to Oliver's backside, and some weight loss which he is gaining back, Oliver seems fine to the family.
Where Oliver was, no one really knows. One thing we can say though is that Oliver is one lucky dog.
You can watch the full report here.


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If you have taken Dr. Pickel's "Introduction to Experiential and Horse Powered Reading" workshop, and would like your program added to our Find a Program page, please contact us. Join the mission to spread HOPE to all students!
Owners: Katherine Kuhn, MA in Rehabilitation Counseling for the Deaf, Doctoral Student in Education Leadership with emphasis in Special Education, Curriculum Service Provider at TUSDI.
Services: Specializing in helping individuals process through anxiety, learned helplessness, learning problems, motivation problems, depression, attention and processing issues. We work with all ages and anyone wanting to connect with themselves through horses. Call for information and learn how much we love our job - and that means we love working with all of you.
Services: We offer equine-assisted psychotherapy and learning and have recently added the Horse Powered Reading program! All of our services are available to children and adults.
2) Horse Powered Reading games and activities based on the Wild West, Colorado, and Bible History.
3) Read to a Mini Program.
4). We also try to do various book giving projects throughout the year.
Services: Helping children that have suffered emotional trauma or abuse with equine assisted personal development activities. Horse Powered Reading is also available for children and adolescents.
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I am also a Website Designer; and there is a special place in my heart for assisting my fellow EAL/EAP practitioners. In fact, I designed the Horse Powered Reading site you are browsing right now! Having a clean, organized website immediately boosts your credibility and builds trust with your audience. Your site can help grow your clientele, allows clients to book and pay for sessions online, is an excellent platform for obtaining donations and grant money, helps increase awareness through social networking, blogging, and email campaigns, allows you to share special events and fundraisers with the public, and more. I am dedicated and determined to bring awareness to our profession. We KNOW horses can change lives! Your site will be clean, easy to navigate, simple to maintain, and ultimately...an authentic reflection of your program and services.
I offer special pricing for certified Equine Specialists and can tailor website packages to fit any budget. Call me to set up a Free Consultation. I'll answer your questions and we can talk horses!
Services: Horse Powered ., multisensory Orton-Gillingham based reading instruction and writing instruction. I am a certified Special Education teacher with over 20 years of experience as a classroom, special education teacher and reading specialist. I believe that horses help children move forward in their confidence and learning both in and out of the classroom.
Services: Northland Counseling Center and Healing Foundations Therapeutic Farm now offers individual Horse Powered Reading using the Eagala model of Equine Therapy.
Phone: (651) 343-5016, Michele Pickel, PhD.
Services: K-16 students / school groups and individual or small group assessment and tutoring to teach reading strategies that build decoding, fluency, vocabulary, and comprehension skills; problem solving, team building, and school success. Contact Michele Pickel for information regarding Horse Powered Reading Curriculum as well as collaborating, coaching, or consulting in the use of Horse-Powered Reading.
Services: Open to individual and group settings. Specializing in equine assisted Learning and Psychotherapy, Riding Lessons, Leadership Development and Conflict Resolution. Special focus classes such as Horse Powered Reading and Tutoring for all reading levels, Parenting from the Barn and Power Tools/Life Skills.
Services: We partner horses with people to have experiential opportunities for learning and personal growth. Activities can focus on communication, relationships, perseverance, problem solving, and other areas of personal growth. Successful Strides offers Horse Powered Reading, Tutoring with a Twist, Youth cooperative skill building, equine assisted learning programs and psychotherapy sessions. Partnering with horses offers clients an experiential opportunity working alongside a non-judgmental, non-verbal, living being. Though gentled and trained, horses still rely on their instinct to respond to situations and they read the intention of those they work with in sessions. It is extremely powerful.
Services: Horse Powered Reading and Math, Life Skills, Psychotherapy, Parenting from the Barn. Not only do the children work on academic skills, but also the issues that keep them from learning in the classroom.
Services: As a Special Ed teacher who is studying to become a licensed counselor, Ellen offers Horse Powered Reading as well as tutoring and Equine Assisted Therapy and Learning.
Services: Riding with HEART is a Premier Accredited Center of the Professional Association of Therapeutic Horsemanship (PATH). Riding with HEART offers adaptive therapeutic riding lessons, Hippotherapy, Veterans program's, and Equine Assisted Learning groups. We offer Horse Powered Reading to children and groups ages 6-18. Call or email for more information. Watch our website for dates of groups and summer learning programs.
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Services: HSVA offers; Horse Powered Reading/Math for individuals and groups, mental health services, therapeutic riding, and other educational programs.
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To download detailed information about our program click here.
Phone: We have 4 locations. Find branch nearest you below.
Services: Equitots is a carefully designed, holistic Equine Assisted Learning program, which benefits children physically and it improves cognitive and sensory, emotional, social and psychological development. Horse Powered Reading is also integrated into the Equitots program as needed.


text:
Mad it's monday
Despite all that I could do, it's Monday again — the weekend ends way-too quick.
Clear skies, however, and quiet here on California's north coast. And we start another plunge into what's called 'making a living,' which depends deeply on the key word, 'living,' and will work our asses off for the next five days until we strike Friday afternoon in the face.
No surprises in store except continual shock and awe — George Carlin mimics: "No one knows what's next, but everybody does it."
(Illustration found here).
And on the topic of work — or not work — in a land of the young, educated and jobless:
The problems start with a lack of jobs.
In 2011, the most recent year for which international comparisons exist, 26.2 percent of Americans between ages 25 and 34 were not working.
That includes those for whom unemployment is a choice (those in graduate school, for example, or taking care of children) and those for whom it is not (the officially unemployed or those who are out of work and no longer looking).
The share was 20.2 percent in Canada, 20.5 percent in Germany, 21 percent in Japan, 21.6 percent in Britain and 22 percent in France.
Robert J. Samuelson at the Washington Post adds:
The answer almost certainly involves employers, not workers.
Businesses have become more risk-averse.
They're more reluctant to hire.
They've raised standards.
For many reasons, they've become more demanding and discriminating.
These reasons could include (a) doubts about the recovery; (b) government policies raising labor costs (example: the Affordable Care Act's insurance mandates); (c) unwillingness to pay for training; and (d) fear of squeezed profits. In practice, motives mix.
The chief victims of this shift in business behavior seem to be the long-term unemployed (more than six months), as some fascinating research by economists William Dickens and Rand Ghayad of Northeastern University suggests.
By their estimates, virtually all the reduction in hiring falls on this group, regardless of their other characteristics (age, education, industry experience).
Many firms seem to have concluded that the long-term jobless are damaged goods.
The big, huge, humongous problem is too much money at the top. Getting any kind of work is getting low wages, which makes the economy act like a drunken sailor, bouncing around and falling.
From Pew Research:
Because of these differences, wealth inequality increased during the first two years of the recovery.
The upper 7 percent of households saw their aggregate share of the nation's overall household wealth pie rise to 63 percent in 2011, up from 56 percent in 2009.
On an individual household basis, the mean wealth of households in this more affluent group was almost 24 times that of those in the less affluent group in 2011.
At the start of the recovery in 2009, that ratio had been less than 18-to-1.
Meanwhile, over the weekend the NRA assholes blustered with a bang, and the new head of the dangerous, delusional organization is a fine fit — Alabama gun nut extraordinaire, James Porter:
Revenge is what's motivating the president's unrelenting attacks on gun owners today," Porter told the group's meeting Saturday amid news that the NRA's membership had grown to a record 5 million.
"Millions of Americans are becoming first-time gun owners," Porter said.
"The media calls it fear.
That's not it.
It's a sense of natural outrage that's been building for quite some time."
Porter, 64, a lawyer from Birmingham, Ala., who defends gun manufacturers, has been building that outrage his whole life.
His father, Irvine C. Porter, was president of the NRA in 1959 — when the son says the NRA was "a glorified shooting society."
At a breakfast Friday, Porter told grass-roots organizers that they are on the front line of a "culture war."
"He seems to come out of a mold that's much closer to the base than David Keene," said Josh Horwitz of the Coalition to Stop Gun Violence.
Whereas Keene was a "steady hand" for the NRA amid controversy, Porter is "a complete wild card," Horwitz said.
"The world's changing around them, and they're hunkering down."
And the firearms, oh, those wonderful firearms:
Meanwhile, Bushmaster wasn't lowering its profile at the NRA confab.
At its booth on the bustling exposition floor, Bushmaster invited children to pose for photos with a .50-caliber sniper rifle with a 30-inch barrel.
The BA50 offers "monstrous long-range power."
In a promotional booklet, George Kollitides, Freedom Group's CEO and a former member of the NRA nominating committee, said Bushmaster builds "each rifle with purpose and passion—yours."
And that's the fluttering news board this morning as time approaches for work. This coming week will have a litany of shit that accounts for how the world operates nowadays. We're looking at a nutcase nation and one fucked-up planet that's cruising for a bruising.
Here now in the quiet and solitude of early morning, life seems gentle and warm without a threat in sight. One neat feeling about these way-early morning is that feeling, that sense of wonder at the day ahead and the non-disclosure of the well-worn thrust of reality later on down the line.
But it's all soft and kitty-like for a little while.
One must remember, Monday is only one day of the week — the rest of the time is mostly just terror.
Posted by: Bruce Maulden // Bullshit, Crime, Economy, Everything, Jobs // assholes, economy, Finance, James Porter, Media, NRA, Politics // May 6, 2013
← Washing the blues away — once again 'Whiplash' Concerns →


text:
package com.mediamath.terminalone.models;

public class TPASCreativeBatchIndex {

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	public String getClickUrl() {
		return click_url;
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	}

	public String getBatchIndex() {
		return batch_index;
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	public void setBatchIndex(String batch_index) {
		this.batch_index = batch_index;
	}

}