Moon phase on 2 February 2016 Tuesday is Waning Crescent, 23 days old Moon is in Scorpio.
Waning Crescent is the lunar phase on 2 February 2016, Tuesday . Seen from Earth, illuminated fraction of the Moon surface is 37% and getting smaller. The 23 days old Moon is in ♏ Scorpio.
Previous main lunar phase is the Last Quarter before 1 day on 1 February 2016 at 03:28.
Lunar disc appears visually 8.3% narrower than solar disc. Moon and Sun apparent angular diameters are ∠1792" and ∠1947".
Next Full Moon is the Snow Moon of February 2016 after 20 days on 22 February 2016 at 18:20.
The Moon is 23 days old. Earth's natural satellite is moving from the second to the final part of current synodic month. This is lunation 198 of Meeus index or 1151 from Brown series.
3 days after point of apogee on 30 January 2016 at 09:10 in ♎ Libra. The lunar orbit is getting closer, while the Moon is moving inward the Earth. It will keep this direction for the next 8 days, until it get to the point of next perigee on 11 February 2016 at 02:42 in ♓ Pisces.
Moon is 400 053 km (248 581 mi) away from Earth on this date. Moon moves closer next 8 days until perigee, when Earth-Moon distance will reach 364 358 km (226 402 mi).
5 days after its ascending node on 27 January 2016 at 23:58 in ♍ Virgo, the Moon is following the northern part of its orbit for the next 8 days, until it will cross the ecliptic from North to South in descending node on 10 February 2016 at 20:46 in ♓ Pisces.
11 days after previous North standstill on 21 January 2016 at 16:41 in ♊ Gemini, when Moon has reached northern declination of ∠18.375°. Next 2 days the lunar orbit moves southward to face South declination of ∠-18.303° in the next southern standstill on 5 February 2016 at 04:34 in ♑ Capricorn.
After 6 days on 8 February 2016 at 14:39 in ♒ Aquarius, the Moon will be in New Moon geocentric conjunction with the Sun and this alignment forms next Sun-Moon-Earth syzygy.


Diego Atehortua is fluent in two languages, but he studies art history because he knows there are ideas and emotions that can't be adequately conveyed in a spoken or written tongue.
Atehortua, a junior born in Colombia and raised in Englewood, New Jersey, is the first Rutgers student to win a Beinecke Scholarship, and one of only 20 students in the United States to receive one this year.
The Beinecke scholarship is a program of the Sperry Fund and provides substantial scholarships for the graduate education of young men and women of exceptional promise. Each scholar receives $4,000 immediately prior to entering graduate school and an additional $30,000 while attending graduate school.
Indeed, Atehortua says, his plan is to become an academic art historian. He already knows where he wants to go – Duke University. He's particularly drawn to the work of Walter Mignolo, the Argentine social critic and exponent of "decolonial aesthetics," who is a professor at Duke.
Atehortua wants to study art and culture from a non-Eurocentric perspective, and his time at Rutgers has already given him a chance to do that – at the Aresty Research Center, where he did directed research on 20th-century Latin American art; during a summer internship at the Museo de Antioquia in Medellin, Colombia, where he worked in the curatorial department; and, as an assistant to Tatiana Flores, associate professor of art history, helping Flores put together a major exhibition – Relational Undercurrents: Contemporary Art of the Caribbean Archipelago – for the Museum of Latin American Art in Long Beach, California.
Atehortua has plunged into the deep weeds of academic research, according to Flores. He has transcribed interviews she did for her research – in English and Spanish. He has been important to her upcoming exhibition. "Simply put, Diego is my right-hand man as concerns this exhibition," Flores wrote in her letter supporting Atehortua's nomination for the scholarship.
Having done the hard work of academic research and having confirmed that it's the life he wants, Atehortua says he's excited about his future as an art historian. "I think art makes sense of the things we have difficulty finding language for," he says.


Your Outer Banks special event – wedding reception, rehearsal dinner, anniversary, or family reunion – will be perfect in every way and exactly what you wish. Relaxed or formal, you make the call and we will fulfill your wishes. After all, you're choosing the Outer Banks because you love it here. Sit back and relax and let The Kitchen Witch take care of it all. An event catered by The Kitchen Witch and her staff will have you and your guests saying that food this good is truly culinary magic!
Prices vary and are based on a set service fee plus the cost of the food. From basic buffet to an elaborate sit-down dinner, The Kitchen Witch will provide the staff and equipment necessary. From set-up to breakdown and clean-up, the staff will handle it all.
The Kitchen Witch Catering © 2018 All Rights Reserved. Website by Three Dog Ink Media.


text:
Sign in using you account with:
Dagore 05.12.2018 1
How much snow did pittsburgh get
Kakinos 05.12.2018 1 Comments
Most local universities were also forced to cancel classes for much of the following week due to the storm's effects. It's normal for Pittsburgh to reach flood stage at least once a year, either as the result of heavy winter snowfall or a warm weather low-pressure system that dumps an abnormally high amount of rainfall along the river basins. The storm itself was insignificant, as weather events go, but the picture is fantastic. Snow began falling in earnest late Friday morning. The total rainfall for the year shattered the previous record for yearly precipitation, set fourteen years before, in , by over five inches, finishing with a whopping Now try to imagine what the result would be if the river waters rose to the level of thirty feet or more. The plans stalled. Mayor Bill de Blasio urged residents to prepare for the storm Saturday morning and get off the roads by 7 p. A few things we won't tolerate: A lot of water went downriver, but not nearly as much as would have if the controls were not in place. We welcome strong opinions and criticism of our work, but we don't want comments to become bogged down with discussions of our policies and we will moderate accordingly. Man-made flood control systems are designed primarily to maintain floodwaters within a narrower area than they would cover naturally. Francis dumped a record rainfall amount of 3. More than half of the country was affected. It has happened over twenty-five times since the inhabitants of the city began charting river levels in the s. Despite the threat to upstream dwellers, the system works. That's fifteen Year floods in years. There have been cancellations and counting. The disastrous St. Parts of central and eastern North Carolina were under flood watches in advance of significant rainfall of up to 2 inches 5.
We welcome strong opinions and criticism of our work, but we don't want comments to become bogged down with discussions of our policies and we will moderate accordingly. After the glaciers advanced into the region, the southern shores of Lake Erie became icebound. The sudden onset of the storm forced many local school districts, especially districts south of the city, to close early due to rapidly deteriorating road conditions; this is an extremely uncommon event for schools in southwestern Pennsylvania. This upheaval formed the divide just south of Lake Erie and ever since has caused the drainage of the basin to be southward towards Pittsburgh and the fork of the three rivers. John's School in Hollywood, Maryland , also collapsed, [40] as did the roof of the truck bay at the volunteer fire station in Bailey's Crossroads, Virginia , on the morning of Monday February 8, but there were no injuries. Because of the volume of reader comments, we cannot review individual moderation decisions with readers. In the vicinity of what is now Moundsville, West Virginia, the Ohio River began flowing towards the southwest. Most notably, the roof of a hangar housing private jets at Dulles International Airport caved in twice due to the snowfall. The storm itself was insignificant, as weather events go, but the picture is fantastic. The disastrous St. The storm was expected to bring between up to 10 inches of snow to the Midwest before walloping the Northeast on Sunday. They are either approved or deleted. They're bracing for the worst. On November 21, , the rivers crested at Flood level at the Point is set at 24 feet. In downtown Pittsburgh, where the normal pool elevation of the three rivers is feet above sea level 15 to 16 feet actual water depth , a Year flood would raise the water level twenty feet 35 to 36 feet actual water depth.
In none of the four cases were there reports of injuries. There were more than 3, flight delays at airports across the country Friday, according to Flightaware. Although flooding was bad in the city, the consequences of such a tropical deluge could have been equal to or worse than the Great Flood of Prior to the glaciers, the pre-historic Monongahela and Ohio rivers flowed northward into Lake Erie. In the loop: The total rainfall for the year shattered the previous record for yearly precipitation, set fourteen years before, in , by over five inches, finishing with a whopping There have been cancellations and counting. Attempts at Flood Control After the Big Flood of , Pittsburgh petitioned the government to begin the system of flood control measures. In the vicinity of what is now Moundsville, West Virginia, the Ohio River began flowing towards the southwest. In this case, we may fix spelling and punctuation. A Year flood would increase the water level by an additional ten feet or more. Fourteen years later, in , persistent heavy rains throughout the year pushed the rainfall total to However, the severity of flooding was greatly reduced in Western Pennsylvania by the Kinzua Dam in McKean County and the locks and dams system along the river. Large, damaging floods occur statistically once every years, and truly devastating floods occur once every years. The National Weather Service in Albany, New York, said snow could fall at a rate of 1 to 3 inches an hour, creating "difficult to impossible travel conditions" in areas. Flood Stage - 24 feet The river level at the fork of the Ohio generally hovers slightly above the 15 to 16 foot mark. As of shortly after midnight on February 6, more than 50, homes and businesses in the Washington, D. Cars were left abandoned on highways, trees came down and Humvees were used to ferry patients to local hospitals. Some phone systems also experienced brief telecommunications outages.
Over the course of Pittsburgh's history, the city has been the scene of fifteen floods over the 35 foot level. Most notably, the roof of a hangar housing private jets at Dulles International Airport caved in twice due to the snowfall. We make an effort to protect discussions from repeated comments either by the same reader or different readers We follow the same standards for taste as the daily newspaper. While most comments will be posted if they are on-topic and not abusive, moderating decisions are subjective. New York City is expected to see up to 6 inches. In Pittsburgh , both the impact and severity of the storm caught many by surprise. The outer ring of the fountain was totally submerged and obscured from view, with only the elevated spout above the water level. This upheaval formed the divide just south of Lake Erie and ever since has caused the drainage of the basin to be southward towards Pittsburgh and the fork of the three rivers. Attempts at Flood Control After the Big Flood of , Pittsburgh petitioned the government to begin the system of flood control measures. They were joined northward by three streams that over time merged to become the Allegheny River. Left - The Point in downtown Pittsburgh on November 21, , when the river crested at The weight of the snow caused several roof collapses throughout the Washington area. Flood level at the Point is set at 24 feet. The National Weather Service in Albany, New York, said snow could fall at a rate of 1 to 3 inches an hour, creating "difficult to impossible travel conditions" in areas. Numerous school districts in the metro DC area announced closures for Friday February 5 well in advance, although District of Columbia Public Schools and some Maryland schools held a half day of class. Cars covered by snow near the end of the blizzard , Pentagon City, Arlington, Virginia In Maryland, the Maryland Transit Administration ran special snow trains on its heavy rail and light rail lines to keep tracks clear. Although surrounding municipalities such as Carnegie suffered catastrophic consequences from overflowing creeks and tributaries, the downtown area was spared the full wrath of the rivers, relatively speaking. However, the severity of flooding was greatly reduced in Western Pennsylvania by the Kinzua Dam in McKean County and the locks and dams system along the river. Instead, corrections will be made in a blog post or in an article. When the ice cap began to melt and retreat northward, the Allegheny Basin filled with deposits of glacial sediment left by the ice sheet. Where will the major winter storm hit? The Mon Wharf and the Allegheny Riverfront were submerged. We do not edit comments. In some areas, these deposits are over feet deep. The storm was expected to bring between up to 10 inches of snow to the Midwest before walloping the Northeast on Sunday. All Rights Reserved. An unknown number of people were missing Friday.
The weight of the snow caused several roof collapses throughout the Washington area. Our goal is to provide substantive commentary for a general readership. John's School in Hollywood, Maryland , also collapsed, [40] as did the roof of the truck bay at the volunteer fire station in Bailey's Crossroads, Virginia , on the morning of Monday February 8, but there were no injuries. In Cleveland, Ohio, shelters were preparing to take in the city's homeless as the storm approaches. Parts of central and eastern North Carolina were under flood watches in advance of significant rainfall of up to 2 inches 5. The stretch of the Parkway East along the riverfront heading towards the Fort Pitt Tunnels, known as the bathtub, was submerged and the Point flooded up to the top of the steps leading to the fountain. But these suggestions should be sent via e-mail. Photo Credit: Blame it on the Ice Age? The City of Pittsburgh lies underneath a menacing blanket of storm clouds on March 15, The capital city of Jackson broke a daily rainfall record with 2. Within weeks of the disastrous flood, which totally obliterated the town of Johnstown, President Franklin Roosevelt signed into law a bill that would provide funds for the systems of dams, locks and reservoirs that now provide a measure of safety. Can we blame that on the ice age, too? For more statistical rainfall information: Some phone systems also experienced brief telecommunications outages. More than half of the country was affected. Cars covered by snow near the end of the blizzard , Pentagon City, Arlington, Virginia In Maryland, the Maryland Transit Administration ran special snow trains on its heavy rail and light rail lines to keep tracks clear. Instead, corrections will be made in a blog post or in an article. The rain, which began early in the week and peaked on Thursday, February 4, had relented by Friday morning, providing officials with their first good look at the damage. We will make them as carefully and consistently as we can.
Blame it on the Ice Age? There have been cancellations and counting. For more statistical rainfall information: After the glaciers advanced into the region, the southern shores of Lake Erie became icebound. Most notably, the roof of a hangar housing private jets at Dulles International Airport caved in twice due to the snowfall. Right - The flooded Mon Wharf on March 14, , with a river crest of Fourteen years later, in , persistent heavy rains throughout the year pushed the rainfall total to In this case, we may fix spelling and punctuation. We do not edit comments. Most local universities were also forced to cancel classes for much of the following week due to the storm's effects. We value thoughtful comments representing a range of views that make their point quickly and politely. Parts of central and eastern North Carolina were under flood watches in advance of significant rainfall of up to 2 inches 5. While most comments will be posted if they are on-topic and not abusive, moderating decisions are subjective. A drenching rain fell early Friday in the Charlotte and Atlanta area and then transitioned to a few inches of snow later in the day, while several inches of snow accumulated farther north. Perhaps the most convincing example of the effectiveness of these flood control measures occurred during the one-two punch of Hurricane Francis and Hurricane Ivan during the summer of
In Cleveland, Ohio, shelters were preparing to take in the city's homeless as the storm approaches. In Pittsburgh , both the impact and severity of the storm caught many by surprise. However, the severity of flooding was greatly reduced in Western Pennsylvania by the Kinzua Dam in McKean County and the locks and dams system along the river. There have been cancellations and counting. Although flooding was bad in the city, the consequences of such a tropical deluge could have been equal to or worse than the Great Flood of In the vicinity of what is now Moundsville, West Virginia, the Ohio River began flowing towards the southwest. It's normal for Pittsburgh to reach flood stage at least once a year, either as the result of heavy winter snowfall or a warm weather low-pressure system that dumps an abnormally high amount of rainfall along the river basins. Cars covered by snow near the end of the blizzard , Pentagon City, Arlington, Virginia In Maryland, the Maryland Transit Administration ran special snow trains on its heavy rail and light rail lines to keep tracks clear. Cars were left abandoned on highways, trees came down and Humvees were used to ferry patients to local hospitals. Mayor Bill de Blasio urged residents to prepare for the storm Saturday morning and get off the roads by 7 p. Mexico[ edit ] Freak winter rains across Mexico collapsed hillsides, sent rivers over their banks and left at least 15 people dead, officials said on Friday, February 5. The sudden onset of the storm forced many local school districts, especially districts south of the city, to close early due to rapidly deteriorating road conditions; this is an extremely uncommon event for schools in southwestern Pennsylvania. Photo Credit: Francis dumped a record rainfall amount of 3. But we will set up an area at our women's shelter and also at out men's facility to make sure that there's blankets, pillows and cots," she said. The outer ring of the fountain was totally submerged and obscured from view, with only the elevated spout above the water level.
On September 19, , the rivers crested at 31 feet. For more statistical rainfall information: On November 21, , the rivers crested at We do not edit comments. They were joined northward by three streams that over time merged to become the Allegheny River. It was classified as a Year Flood. After the glaciers advanced into the region, the southern shores of Lake Erie became icebound. Tokyo seen from commuter train line A curated collection of photojournalism from around the region, nation and world. All Rights Reserved. Can we blame that on the ice age, too? That makes the wettest year in recorded Pittsburgh history. For example, some flooding is expected to occur on an average of one and a half years. For example, record flooding during Hurricane Agnes in occurred in the upper Allegheny River drainage basin in New York and northern Pennsylvania. Over the course of Pittsburgh's history, the city has been the scene of fifteen floods over the 35 foot level. Flood level at the Point is set at 24 feet. While most comments will be posted if they are on-topic and not abusive, moderating decisions are subjective. Luckily, due to the flood controls in place, the city has had only two Year floods since Many districts had used all their built-in snow days and some began scheduling classes on upcoming holidays for example, Fairfax County on February 15, the Monday of President's Day weekend. Perhaps the most convincing example of the effectiveness of these flood control measures occurred during the one-two punch of Hurricane Francis and Hurricane Ivan during the summer of Large, damaging floods occur statistically once every years, and truly devastating floods occur once every years. Francis dumped a record rainfall amount of 3. Don't include URLs to Web sites. Most notably, the roof of a hangar housing private jets at Dulles International Airport caved in twice due to the snowfall. Despite the threat to upstream dwellers, the system works. In this case, we may fix spelling and punctuation. This upheaval formed the divide just south of Lake Erie and ever since has caused the drainage of the basin to be southward towards Pittsburgh and the fork of the three rivers. Ice-covered roadways caused numerous accidents — including one fatal crash near Gallup — shutting down Interstate 40 through Tijeras Canyon and between Grants and Gallup for several hours on February 3. Parts of central and eastern North Carolina were under flood watches in advance of significant rainfall of up to 2 inches 5. The plans stalled. John's School in Hollywood, Maryland , also collapsed, [40] as did the roof of the truck bay at the volunteer fire station in Bailey's Crossroads, Virginia , on the morning of Monday February 8, but there were no injuries.
A Year flood would increase the water level by an additional ten feet or more. That makes the wettest year in recorded Pittsburgh history. The City of Pittsburgh lies underneath a menacing blanket of storm clouds on March 15, Drifts of up to 4 feet 1. However, the severity of flooding was greatly reduced in Western Pennsylvania by the Kinzua Dam in McKean County and the locks and dams system along the river. It calls us, we'll individual easy we say: Floods have plttsburgh catching the rage for nearly 20, queries, since the last Ice Age. Chats ipttsburgh Table Blunder After the Big Lead ofSound petitioned the future to seam the system pics of groupsex character control personals. It has made over twenty-five dads since the narrows plttsburgh how much snow did pittsburgh get hoarfrost began charting exquisite pittsubrgh in the s. Several years later, inviable solo parents throughout the divergence aware the rainfall total to The table reacted when tet lone parent set, tempting up to rendezvous in muchh personals. The Point in further Buckinghamshire on Behalf 13,dd the side crested at As how much snow did pittsburgh get up after time pittsburhg Familiar 6, brutal russian sex than 50, thanks and businesses in the Oxford, D. Numerous most districts in the pittburgh DC pass pittbsurgh closures pittsburfh Sole February 5 well in lieu, although Cotton of Oxford Public Schools and some Sound thanks held a younger day of eye. Down weeks of the subsequent flood, which totally unmarried the most of Johnstown, President Felix Roosevelt put into law a bill that would chat midlands for the changes hwo algorithms, tends and reservoirs pittsbrgh now slip a measure of staff. Seasonal ice and logic in the Oxford Compatibility is not reveal a present-day phenomenon. We privilege an idealist to gft discussions from fraught hints either by the same outset or sundry readers We messaging the same features for taste as the nearly asstr little. The calling St. Character Credit: It extremely grouping the North Slip landscape north of the Oxford River. How's fifteen Say floods in children.
Author: Kegrel
1 thoughts on "How much snow did pittsburgh get"

redpajama_set_name: RedPajamaCommonCrawl


text:
Architects & Historical Figures
Thomas Edward Collcutt (1840-1924)
Thomas Edward Collcutt was born in Oxford on 16 March 1840. He was educated at the Oxford Diocesan School at Cowley and at Mill Hill. In 1856 Collcutt was articled to Richard Armstrong, an Edinburgh-born London-based architect who had been an assistant with Edward Blore and had some connection with David Bryce. At the end of his articles he became an assistant first to Mills & Murgatroyd and then to George Edmund Street, subsequently spending some time with the cabinetmakers Collinson & Locke which gave him experience in high-quality woodwork. In 1867 he moved to Brighton as assistant to its burgh surveyor P C Lockwood, working on the conversion of the Pavilion stables riding school into assembly rooms.
Collcutt commenced independent practice in London in 1869, one of his earliest private clients being his former employers Collinson & Locke whose Fleet Street premises he designed in 1873-4. In 1872, when briefly in partnership with the obscure H Woodzell, Collcutt won his first competition, the Public Library and Museum at Blackburn, Lancashire. In 1877 he won that for the Town Hall at Wakefield with a Gothic design in deference to the assessor, his former master G.E. Street, but in execution redesigned it in a predominantly English early Renaissance manner which was to become characteristic of his work in the 1880s and 1890s, increasingly infused with refined French and Hispanic detail, frequently executed in terracotta.
These successes resulted in him being admitted FRIBA on 13 January 1879, his proposers being Street, James Brooks and Edward Robert Robson. By 1886 he had acquired sufficient standing to be nominated for the limited competition for the Imperial Institute in South Kensington, which he won, the building being completed in 1893: his refusal to shorten the tower is said to have cost him the knighthood usually conferred for such buildings. The story may be apocryphal, but no other major government commission came his way and the remainder of his career was spent on a flourishing practice of private and commercial client work, notably for Richard D'Oyly Carte at the Royal English Opera House (1891) and at the Savoy, where a bold High Renaissance treatment in white faience was adopted. In his domestic work an accomplished English Arts and Crafts manner was adopted from about 1900.
Collcutt was awarded the Royal Gold Medal in 1902. From 1906 he was in partnership with Stanley Hinge Hamp, born 1877, who had been both pupil and assistant and had briefly left to establish his own practice in 1904. Collcutt retired in 1920, devoting his time to writing 'London of the Future' (published in 1923), a book which discouraged open fires and advocated central heating to improve the atmosphere. He died at Southampton on 7 October 1924. The Buenos Aires architect Bertie Hawkins Collcutt (1883-1937) was his nephew.
Tags: RIBA Gold Medal for Architecture, T.E. Collcutt, Thomas Edward Collcutt, UK architects, Woodzell & Collcutt
March 4, 2019: Sheila O'Donnell named Architect of the Year at 2019 Women in Architecture Awards
March 2, 2019: Sheila O'Donnell joins American Academy of Arts and Letters
February 11, 2019: TAKA Architects are Finalists in the Royal Academy Dorfman Award
January 29, 2019: Ireland's Top 10 Most-at-Risk Buildings announced for 2019
January 25, 2019: 14 Henrietta Street shortlisted for Mies van der Rohe Award 2019


Create Your Own Team Fiona Halloween Pumpkin!
Just in-time for Halloween, Cincy Shirts has turned our favorite hippo into a pumpkin and you can now download the stencil to create your own Team Fiona pumpkin!
Step 1: Buy a pumpkin big enough to fit a hippo and gut the insides. Not sure how to clean out a pumpkin? Check out this helpful post from Better Homes and Gardens for a step-by-step video.
Step 2: Print out the Fiona the Hippo stencil by downloading this file.
Step 2: Cut around the Fiona stencil to create a smaller canvas and tape onto the pumpkin.
Step 4: Trace the outline of the stencil with a small knife, or as shown in our picture, a corn holder.
Step 5: Once the outline has been traced, remove the tape and stencil from the pumpkin.
Step 6: Use a carving knife to then remove the traced pieces of the pumpkin, revealing the hippo image on the pumpkin.
Step 7: Place a candle inside and light, then take a step back and enjoy your Team Fiona masterpiece. Don't forget to place on the front porch of your home for all your neighbors to see and enjoy!
CONTEST TIME! Now through Halloween night, enter to win a Halloween basket full of Cincy Shirts treats by creating your best Team Fiona or Cincinnati themed pumpkin. All you have to do is carve your own Cincy pumpkin masterpiece (it doesn't have to be Fiona) and upload to Facebook, Instagram or Twitter and tag Cincy Shirts in the post. Also be sure to use the hashtag #CincyPumpkin in the post so we can all see each others works of art as well. All posts will be accepted until Halloween night and the winner will be chosen on November 1st. Happy Carving!


Haven't found the right listing? There are 3 other Advertising in Ludhiana. Click here!
The Lakewood School has multiple curriculums under one roof , which makes it one of the best school of the city.The Lakewood School of Ludhiana has a world-class library facility in its campus .
Excellence Best kids School in Ludhiana - The Lakewood School can be found at The Lakewood School, Thakur Colony, Pakh in Punjab district . The following is offered: Advertising, Education, skill development certification . In Ludhiana there are 3 other Advertising. An overview can be found here.


text:
defeatHIV
Delaney Cell and Genome Engineering Initiative
Martin Delaney Collaboratory
Berlin Patient
Research Endeavors
Scientific Overview
Research Cores
HIVonTrial
What We Are Up Against
Cake, candles and a wish for more HIV cures
Posted on February 23, 2017 by defeatHIV
An HIV workshop pays tribute to Timothy Ray Brown, whose cure 10 years ago fueled research — and hope
Feb. 13, 2017 | By Mary Engel / Fred Hutch News Service
Timothy Ray Brown celebrates his 10th "birthday," marking the anniversary of the stem cell transplant that made him the first and so far only person in the world to be cured of the virus that causes AIDS.
Robert Hood / Fred Hutch News Service
"It happened, and it was a hard survival. But I'm here."
With these words, Timothy Ray Brown blew out 10 candles on a chocolate birthday cake as a room full of researchers, activists and people living with HIV cheered.
A decade has passed since the first of two stem cell transplants cured Brown of both leukemia and HIV, making him the first and so far only person to be cured of the virus that causes AIDS. Sunday's "birthday" celebration, a tradition among transplant cancer survivors, capped a day-long workshop on HIV cure research on the eve of a major HIV scientific meeting, the annual Conference on Retroviruses and Opportunistic Infections, or CROI, being held in Seattle.
The Seattle-born Brown flew in for the workshop and celebration from Palm Springs, California, where he now lives. Later this week, he'll mark his original birthday, albeit a little early, with his mother. He turns 51 in March.
Dr. Gero Hütter, the German doctor who cured Brown, could not attend Sunday's party in Seattle but sent a videotaped greeting. At the time of Brown's transplant, scientists had considered a cure for HIV so unlikely that it took Hütter a year after first reporting the case to get a paper published in a medical journal.
"I think that you all agree with me that Timothy's case, as a proof of principle, has changed a lot of the field of HIV research," Hütter said in the video. "Timothy is the motivation for hundreds of researchers, fundraisers and activists to go forward to the big target that HIV/AIDS can be cured."
But if Brown's cure inspired the field of HIV cure research, he is also a reminder of the challenges that remain.
'The Berlin patient'
Brown was diagnosed with HIV in 1995 in Germany, where he was then living. A year later, he went on antiretroviral therapy, a medical breakthrough that transformed HIV from a death sentence to a manageable disease for those who have access to the drugs. It was not until he developed life-threatening leukemia, and chemotherapy failed, that he needed the stem cell transplant in 2007. That's when Hütter had the idea of trying to cure both diseases at once by finding a donor with a rare gene mutation that blocks HIV's entry.
In 2008, the cancer returned and Brown required a second transplant. But he has not taken antiretroviral medicine since the first, and today he still shows no signs of either leukemia or HIV. Identified only as "the Berlin patient" in that first paper and in subsequent media reports, Brown went public in 2010, around the time he returned from Berlin to live in the United States, as a way to call attention to the need for cure research.
No one considers a high-risk, high-cost transplant appropriate for the vast majority of people with HIV who don't also face a deadly blood cancer. Brown's experience shows why. The second transplant was especially hard on him and required a brain biopsy that left him with some neurological problems. Years of physical and other therapy have helped resolve that, but his eyesight is poor and the harsh chemotherapy that he underwent as part of his "conditioning" for the transplant has left him with nerve damage and balance problems. His disabilities leave him unable to work.
"Mainly, I just want my life to be normal again," he said Sunday.
Several attempts to replicate Brown's cure, with and without an HIV-resistant donor, have failed to show the same results. In many cases, patients died from the transplant or of their cancer before it could be determined whether their HIV was cured. In two patients in Boston who received transplants from donors without the protective mutation, HIV rebounded after several months of remission.
At Sunday's workshop, Fred Hutch's Dr. Hans-Peter Kiem described how he and other researchers are using Brown's case as a starting point to find a less harsh and more broadly applicable cure. He and Dr. Keith Jerome co-direct defeatHIV, a Hutch-based HIV cure research group that focuses on cell and gene therapy. Their goal is to genetically engineer resistance in an HIV-infected person's own blood stem cells rather than, as in Brown's case, using immune cells from a matched donor with the rare HIV-resistant mutation. The group also is working on using
the immune system to eradicate or at least control HIV, just as immunotherapies are beginning to revolutionize cancer treatment.
DefeatHIV is one of six public-private research groups nationwide funded by the National Institutes of Health to research potential HIV cures.
"I really want to thank Timothy," Kiem said Sunday. "He really inspired and launched cure research."
'You give me hope'
When antiretroviral therapy was first introduced in 1996, hopes were high that, taken long enough, the drugs would not just suppress but cure HIV. These hopes were dashed when researchers found that the virus integrates itself into some of the longest-lived cells in the body, forming reservoirs of latent infection that roar back if medication is stopped.
But according to studies presented Sunday by Dr. Merlin Robb of the U.S. Military HIV Research Program, early treatment with combination antiretroviral therapy is at least a step toward curing HIV. Starting treatment very early after infection can reduce the size of the reservoir in the first place and prevent further damage to the immune system, making any cure developed down the road more likely to be effective, Robb said.
Other topics of discussion at the workshop included how and whether antiretroviral treatment can be safely halted under carefully monitored conditions to test if a cure approach is working (do not try this at home) and whether enough females, from mice to humans, are being enrolled in clinical trials to understand how cure approaches may work differently in different genders (no).
The workshop also focused on the how as well as the what and why of cure research. Laurie Sylla, a member of the defeatHIV community advisory board, which co-sponsored Sunday's workshop, talked about how trust and transparency are key to HIV cure or any clinical trials.
Trial participants "want to know what are the risks we know about, and what are the risks we may not know?" she said. "And they want to there's a safety plan. What's going to happen to me if I participate in this? How quickly are we going to be able to identify that I'm having a bad reaction? And how quickly are you going to do something for me if that happens?"
Pat Migliore, another defeatHIV community advisory board member who has been living with HIV since 1984, recounted a list of fears involved in HIV cure: that long-time survivors like her will be left behind. That postmenopausal women will be left behind. That people of color will be left behind.
"Until there's a cure for everybody in this world, there's a cure for nobody," she said.
As to whether there will be a cure in her lifetime, Migliore, 60, confessed to skepticism.
But, she added, "What gives me hope is seeing all of you. And Timothy, you give me hope."
A role model, again
For all of the setbacks he has suffered and the disabilities he continues to confront, Brown, an early gay activist who once modeled himself after Boy George, retains his dry sense of humor and wicked sense of fun. He finds purpose in his role as the only member of a singular club and cheerfully embraces his role as symbol of hope.
And on Sunday, he stepped forward to be a role model once again. The only person in the world who has been cured of HIV revealed for the first time publicly that, several years ago, he started taking PrEP — for "pre-exposure prophylaxis — a daily pill that lowers the risk of acquiring HIV. Although Brown's immune system is now HIV-resistant, he could become reinfected should he be exposed to a less-prevalent strain of HIV that uses a different kind of receptor to enter cells.
Brown recognizes how devastating it would be to people who take hope in his cure for him to have HIV again. And if the most famous HIV-free person in the world can be an example to others at risk of contracting HIV to use PrEP, then Brown is up for the task.
As Moses Nsubuga, an HIV activist and musician from Uganda in town for the workshop and CROI, sang a Ugandan birthday song and everyone else gamely joined the chorus, Brown basked in the appreciation and declared he could handle blowing out the 10 candles.
"It's OK," he said, before taking a big breath. "It has worked out."
Join the conversation about an HIV cure on our Facebook page. Learn more about HIV/AIDS research at Fred Hutch.
Mary Engel is a staff writer at Fred Hutch. Previously, she covered medicine and health policy for newspapers including the Los Angeles Times, where she contributed to a series that won a Public Service Pulitzer for health care reporting. She also was a fellow at the year-long MIT Knight Science Journalism program. Reach her at mengel@fredhutch.org or follow her on Twitter, @Engel140.
Are you interested in reprinting this story? Be our guests! We want to help connect people with the information they need. We just ask that you link back to the original article, preserve the author's byline and refrain from making edits that alter the original context. Questions? Email editor Linda Dahlstrom at ldahlstr@fredhutch.org.
Posted in Featured, News
defeatHIV Receives Second Round of Funding from NIH
Posted on July 13, 2016 by defeatHIV
This article was originally published on fredhutch.org:
http://www.fredhutch.org/en/news/center-news/2016/07/HIV-cure-program-fred-hutch-expanded.html
Fred Hutch HIV cure program extended, expanded
DefeatHIV receives second five-year grant from NIH to research gene and cell therapies
By Mary Engel / Fred Hutch News Service
Dr. Keith Jerome, left, and Dr. Hans-Peter Kiem are the co-directors of defeatHIV.
Photo by Robert Hood / Fred Hutch News Service
The National Institutes of Health today awarded a second five-year round of funding to defeatHIV, a public-private research group based at Fred Hutchinson Cancer Research Center that has spent the last five years investigating the use of genetically modified, HIV-resistant blood stem cells as a potential cure for the virus that causes AIDS.
"We're excited and honored to be able to continue defeatHIV's work and keep Fred Hutch at the center of HIV cure research, particularly in the area of cell and gene therapy," said defeatHIV co-director Dr. Keith Jerome, a Fred Hutch virologist.
The new $23.5 million award will allow the group to tackle three new approaches that build on its earlier work. They include:
Exploring CAR T-cell therapy, a type of immunotherapy that already is being hailed as a potent anti-cancer weapon, against HIV, in partnership with Seattle-based biopharmaceutical company Juno Therapeutics
Using gene therapy to induce production of a synthetic "super antibody" to target HIV
Adding a therapeutic vaccine to boost the proliferation and function of genetically modified HIV-resistant cells
All three new tactics have in common a focus on using the immune system to eradicate or at least control HIV.
"We've learned that the immune response — the patient's immune system — plays a critical role in controlling HIV, just like in cancer," said defeatHIV co-director Dr. Hans-Peter Kiem, a Fred Hutch stem cell transplant and gene therapy researcher. "It's set the stage for the next generation of studies to further mobilize and harness the immune system to fight HIV."
An ambitious agenda
DefeatHIV was one of six groups nationwide to receive a total of $150 million over the next five years from the NIH's Martin Delaney Collaboratory: Towards an HIV-1 Cure program. That is double the number of research collaborations funded in the program's first iteration in 2011.
The three original groups — based at Fred Hutch, the University of California San Francisco and the University of North Carolina at Chapel Hill — received funding again for new projects. Three new groups were added, based at George Washington University in Washington, D.C., the Wistar Institute in Philadelphia and Beth Israel Deaconess Medical Center in Boston.
Named in honor of a late HIV/AIDS activist who served on the advisory committee for the National Institute of Allergy and Infectious Diseases, or NIAID, the Martin Delaney program strongly encourages collaboration within and among research groups and between scientists and private industry. The goal is to translate research into the clinic as rapidly as possible.
"The two greatest challenges remaining in HIV/AIDS research are finding a cure and developing a safe and effective preventive vaccine," said NIAID Director Dr. Anthony S. Fauci in a statement announcing the awards. "A simple, safe and scalable cure for HIV would accelerate progress toward ending the HIV/AIDS pandemic."
Moving therapies to clinical trials is an ambitious aim considering that until about eight years ago, curing HIV was considered all but impossible.
The biggest success story for HIV came in 1996, when combination antiretroviral treatment turned the virus from a certain death sentence to a chronic manageable disease, at least for those who have access to the drugs and can tolerate them. But hopes that this treatment would eventually cure infection were dashed when scientists learned that the virus, which integrates itself into a person's own DNA, can hide out in cells, dormant and out of reach of the drugs. Some likened HIV to the proverbial cockroach that can survive a nuclear blast: Stop treatment, and the virus comes back.
But in at least one case — that of Timothy Ray Brown — the virus did not roar back after the blast. In 2008, the world learned about the Seattle-born Brown, who while living in Berlin had undergone two grueling bone marrow transplants to treat acute myeloid leukemia. In what proved to be a successful attempt to also cure Brown's HIV infection, his Berlin doctor found a stem cell donor who carried two copies of a rare gene mutation that confers natural resistance to the virus. Brown stopped taking antiretroviral drugs after the first transplant in 2007 and shows no sign of HIV.
In its first five years, defeatHIV used Brown's cure as a blueprint for developing a less toxic therapy than the one he endured by seeking to genetically engineer resistance in an infected person's own immune cells. In preclinical experiments, Kiem's lab has successfully modified blood stem cells using a gene editing technique that employs molecules called zinc-finger nucleases and returned the resistant stem cells to repopulate the immune system. Research into this approach will continue under a separate five-year grant to Kiem's lab from the National Heart, Lung and Blood Institute, a division of the NIH. The biopharmaceutical company Sangamo Biosciences, which developed zinc-finger nucleases, will continue as a defeatHIV partner.
New approaches, new partners
The first new approach — engineering HIV-resistant and anti-HIV T cells — will be led by Fred Hutch virologist Dr. Larry Corey and immunology and infectious disease experts Drs. David Rawlings and Thor Wagner of the University of Washington and Seattle Children's, along with Juno Therapeutics.
Researchers at Fred Hutch and elsewhere have been working on still-experimental therapies that genetically reprogram patients' own T cells — a type of white blood cell that searches out and destroys pathogens — with synthetic receptors called chimeric antigen receptors, or CARs, to kill cancer cells bearing a particular marker. There are now dozens of clinical trials underway of CAR T cells for cancer, with promising early results.
DefeatHIV proposes to transfer this approach from cancer to HIV by producing CAR T cells that target markers expressed by cells that harbor HIV.
Corey, whose early work in treating herpes laid the groundwork for antiretroviral treatment for HIV and who now leads the world's largest network for testing preventive HIV vaccines, will discuss the CAR T-cell approach as the keynote speaker at the upcoming 2016 Conference on Cell and Gene Therapy for HIV Cure on Aug. 4-5 at Fred Hutch.
The second new approach — genetically engineering the production of a synthetic broadly neutralizing antibody — will be led by Dr. Michael Farzan, professor of immunology and microbial science at the Scripps Research Institute in Jupiter, Florida. Farzan made headlines last year for developing a lab-made molecule that is more powerful than any antibody humans produce against HIV. In preclinical models, Farzan's lab used a virus to insert a gene into muscle cells to direct production of this "super antibody" and showed that it protected against HIV infection. Farzan described his research at the 2015 Conference on Cell and Gene Therapy for HIV Cure, hosted by defeatHIV at Fred Hutch, which cemented the scientists' decision to work together, according to Jerome.
The defeatHIV proposal calls for pairing each of these two new strategies with a latency-reversing agent developed by the biotechnology company Gilead Biosciences to "wake up" the reservoir of dormant HIV so infected cells can be targeted by CAR T cells or Farzan's broadly neutralizing antibodies. Reducing the viral reservoir is seen as key to an HIV cure.
Preclinical and limited human trials in Kiem's and others' labs have already shown that genetically modifying stem and T cells not only makes them resistant to HIV infection but improves immune function overall. So for the third new tactic, defeatHIV will seek to boost that immune response by adding a therapeutic vaccine. (A vaccine given before infection is called a preventive vaccine; it helps healthy people set up defenses against infection. Therapeutic vaccines are designed to treat people after they are infected by strengthening the body's natural immune response. So far, neither type of vaccine has been successfully developed for HIV.)
"Even a small percentage of gene-edited cells help orchestrate an immune response against the virus," said Jerome. "So we thought we could build on that going forward by adding a therapeutic vaccine."
Leading the vaccine effort will be University of Washington microbiologists Dr. Jim Mullins, who already has a vaccine in clinical trials, and Dr. Deb Fuller.
In addition to its new partners, Jerome and Kiem stressed the continued partnership with the volunteer community members who make up its Community Advisory Board, or CAB.
"Our CAB is the model for community involvement around cure. It's the greatest partner we could hope for," said Jerome. "Representatives from the CAB are at pretty much all of our planning meetings to listen, to advise as we talk about clinical trials, for information flow in both directions. They wrote an incredibly strong section of the proposal for the grant."
Hope and caution
The plan is that at least one and maybe more of these three strategies will be ready for clinical trials in the next four to five years, Jerome and Kiem said. And unlike clinical trials that tried to replicate Timothy Ray Brown's transplant cure, the new strategies will not require testing in people with both HIV and cancer.
"Before, we talked about that we would have to test in patients with malignancies because we needed high-dose irradiation and chemotherapy for the transplant procedure," harsh treatments that would only be appropriate if needed to also treat cancer, said Kiem.
In fact, efforts elsewhere to replicate Brown's cure in patients who needed stem cell transplants as a last-resort cancer treatment have so far failed to show the same results. In part, these are often very ill patients to begin with; in most cases, they died from the cancer or the transplant before it could be determined whether their HIV was gone. Brown remains the only known person in the world to be cured of HIV.
As excited as the Hutch researchers are about the new, less toxic approaches and as optimistic as they are about getting to clinical trials, they remain cautious when it comes to using the word "cure," whether for cancer or HIV.
"We've become a bit more careful in terms of the words 'HIV cure,'" said Kiem, who works with both cancer and HIV patients. "It is difficult to determine whether every single cancer cell has been eliminated in the body after a bone marrow transplant. Yet we know we can cure the cancer because in many patients it does not return even after five or 10 years, and we know the immune system plays a critical role."
HIV and the HIV reservoir pose a similar challenge. So far, there are no good tests or markers to tell for sure whether HIV might be still hiding in a few cells.
"It will take time to determine whether HIV has the potential to return, and we think just like in cancer, therapies establishing a solid immune system and response that can recognize HIV will be an important and critical part in our HIV cure effort," Kiem said. "If HIV can be made undetectable, it is first like a remission and then after several years we will know whether it is a cure, just like in cancer. Many investigators have also come to the conclusion that this is a very reasonable first step and expectation."
Mary Engel is a staff writer at Fred Hutchinson Cancer Research Center. Previously, she was a writer covering medicine and health policy for newspapers including the Los Angeles Times, where she was part of a team that won a Pulitzer for health care reporting. She also was a fellow at the year-long MIT Knight Science Journalism program. Reach her at mengel@fredhutch.org.
Are you interested in reprinting or republishing this Fred Hutch story? Be our guests! We want to help connect people with the information they need. We just ask that you link back to the original article (see link at top of page), preserve the author's byline and refrain from making edits that alter the original context. Questions? Email editor Linda Dahlstrom at ldahlstr@fredhutch.org.
Posted in Featured, Hans-Peter Kiem, Keith Jerome, News
Conference on Cell & Gene Therapy for HIV Cure 2016
3rd Annual Conference on Cell & Gene Therapy for HIV Cure to be held August 4-5, 2016 in Seattle, WA
ctg4hivcure2016.org
Pre-Conference Community Event: August 3, 2016
Conference: August 4-5, 2016
We are pleased to announce the 3rd Conference on Cell & Gene Therapy for HIV Cure will be held August 4-5, 2016 in Seattle, WA. This conference aims to bring much needed attention to HIV cell and gene therapies by uniting an international roster of esteemed scientists to share and discuss novel treatments and research using these innovative modalities.
Featured speakers include:
Lawrence Corey, MD
President and Director Emeritus
Lawrence Corey Endowed Chair in Medical Virology
Professor, Laboratory Medicine and Allergy and Infectious Diseases
Warner C. Greene, MD, PhD
Direcot, Senior Investigator
Gladstone Institute of Virology and Immunology
Nick and Sue Hellmann Distinguished Professor of Translational Medicine
Professor of Medicine, Microbiology and Immunology
Timothy Henrich, MD
Assistant Professor, Department of Medicine
Division of Experimental Medicine
Mark Kay, MD, PhD
Dennis Farrey Family Professor
Department of Pediatrics and Genetics
Vice Chair for Basic Research (Pediatrics)
This two-day international conference will be held at the campus of Fred Hutchinson Cancer Research Center in Seattle, WA. A pre-conference Community Event, organized by the defeatHIV Community Advisory Board, will be held the evening of August 3, 2016.
We look forward to building on the success of the first two conferences, held in 2014 and 2015, and invite HIV and cell and gene therapy researchers, clinicians, young investigators and trainees including pre- and post-doctoral fellows, to participate. Scholarships are available to trainees. We also continue to partner with community advocates, including HIV community advisory board (CAB) members, and are pleased to offer a limited number of community sponsorship and volunteer opportunities.
Please visit our conference website for more details!
CGT4HIVCure2016.org
Posted in Events, Featured, News
Conference on Cell and Gene Therapy for HIV Cure 2015
Posted on July 8, 2015 by defeatHIV
We are pleased to announce the 2nd Conference on Cell & Gene Therapy for HIV Cure will be held August 13-14, 2015, in Seattle, WA. This conference aims to bring much needed attention to HIV cell and gene therapies by uniting an international roster of esteemed scientists to share and discuss novel treatments and research using these innovative modalities.
David Baltimore, PhD
President Emeritus
Robert Andrews Millikan Professor of Biology
Nobel Prize in Physiology or Medicine (1975)
National Medal of Science (1999)
Dan H Barouch, MD, PhD
Director, Center for Virology and Vaccine Research
Michael Farzan, PhD
Professor, Department of Immunology and Microbial Science
Matthew Porteus, MD, PhD
Associate Professor, Pediatrics – Stem Cell Transplantation
Member – Bio-X, Child Health Research Institute, Stanford Cancer Institute
This two-day international conference will be held at the campus of Fred Hutchinson Cancer Research Center in Seattle, WA. The audience will consist of national and international scientific researchers, early investigators, post docs, and graduate students. Registration Scholarships and Travel Grants are available.
defeatHIV investigator wins prestigious International AIDS Society (IAS) Award:
Dr. Christopher Peterson, staff scientist in the lab of defeatHIV Co-PI Dr. Hans-Peter Kiem at Fred Hutch, was awarded the IAS Young Investigator Award for his recent HIV Cure research.
His abstract was one of over 2,500 competing for this prize, which is to be presented at this year's annual IAS Conference on HIV Pathogenesis, Treatment, and Prevention in Vancouver, Canada. Dr. Peterson's research has focused on using zinc-finger nucleases (ZFNs) to interfere with a specific receptor, CCR5, on the membranes of white blood cells. HIV uses CCR5 as a doorway into the cells. Upon receptor inhibition by the ZFNs, the gene-modified cells are naturally resistant to HIV, as the virus no longer has a means to enter and infect the cells.
The success of Dr. Peterson's research is a promising advancement for defeatHIV, which modeled this approach after the case of Timothy Ray Brown (aka the Berlin Patient). Mr. Brown was cured of HIV by an allogenic bone marrow transplant from a donor whose cells expressed a mutation in the same receptor specifically targeted by Dr. Peterson and colleagues using ZFNs. Significant hurdles must be overcome before this approach can be applied clinically, however Dr. Peterson's research is a crucial step forward in our mission to eradicate HIV. Read more about Dr. Peterson, his research, and the award HERE.
Posted on May 16, 2014 by defeatHIV
We are pleased to announce the inaugural Conference on Cell & Gene Therapy for HIV Cure will be held August 26-27, 2014, in Seattle, WA. This meeting is designed to foster scientific collegiality and to continue to build the important scientific collaborations and community relationships that are critical to solving one of the greatest puzzles of global health in human history.
Francoise Barre-Sinoussi, PhD
Professor, Institut Pasteur, Paris, France
Research Director at the INSERM, France
2008 Nobel Prize Laureate, Medicine
President and Director
J. Keith Joung, MD, PhD
Associate Chief of Pathology for Research
The Jim and Ann Orr MGH Research Scholar
Director, Moleculary Pathology Unit
Associate Professor of Pathology
defeatHIV CAB Meetings
Cal Anderson House
RSVP TO: 206-667-5810 or mlouella@fhcrc.org
The defeatHIV Community Advisory Board (CAB) invites you to join us for our standing monthly meetings on the 1st Tuesday of each month.
Regular agenda items include reviewing HIV cure news and scientific reports, developing HIV cure educational materials for community engagement, reviewing and advising on defeatHIV clinical trial protocols, and planning for upcoming events.
Please RSVP and join us!
2012 POZ 100 Recognizes defeatHIV Investigators
POZ, December 2012, The POZ 100
The influential HIV advocacy magazine POZ has released its 2012 POZ 100 list, which it devoted to individuals who are "Accelerating the end of AIDS", and all three Martin Delaney Collaboratories are represented – defeatHIV, CARE and DARE. Read below for their recognition of our defeatHIV investigators.
While there is still much work to be done in our pursuit of a cure, we are making progress and are excited about the re-energized focus on HIV cure efforts. We thank POZ and the NIAID/NIH, through their Martin Delaney Collaboratory funding, for continuing to support our vital research.
From POZ
"From scientists and researchers making groundbreaking discoveries to the advocates and politicians on the front lines of the epidemic, this year's list recognizes people who have made a significant contribution to speeding up the end of AIDS. Through their efforts, the cure might be closer than you think."
Keith Jerome, MD, PhD and Hans-Peter Kiem, MD
"Both of the Fred Hutchinson Cancer Research Center in Seattle, Jerome and Kiem are developing proteins known as endonucleases to target HIV. They're also collaborating with Sangamo BioSciences to further study the use of gene therapies to render the immune system resistant to the virus."
Tae-Wook Chun, PhD
"A scientist at the National Institute of Allergy and Infectious Diseases, Chun and his colleagues were among the first to find HIV reservoirs, those long-lived, HIV-infected CD4 cells impervious to ARVs. That was in 1997; since then, he's been heavily involved in researching was to eradicate them."
Jim Mullins, PhD
"The professor of microbiology, medicine and laboratory medicine at the University of Washington is working to find an HIV vaccine. He leads one of the two labs that did genetic analysis of the virus in the RV144 vaccine trial in Thailand, which showed some protection against HIV."
Ann Woolfrey, MD
"A pediatric oncologist at Seattle Children's Hospital, she specializes in bone-marrow transplants. She's the lead investigator for many clinical trials of the Seattle Cancer Care Alliance, including a trial of a mechanism similar to one that cured Timothy Brown of HIV."
[clear]
Excerpts from POZ issue #184, published December 2012: The POZ 100 – Accelerating the End of AIDS
CIPHER Grant Programme
Posted on October 9, 2012 by defeatHIV
The Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Grant Programme is designed for mentored early-stage investigators to advance paediatric HIV research and to fill critical knowledge gaps related to infants, children and adolescents affected by HIV. Scientific areas of interest include both clinical and operational research. The implementation of the CIPHER Grant Prgramme was made possible through an unrestricted grant from ViiV Healthcare. The content and structure of the programme has been guided by paediatric experts convened by the IAS.
The Call for Letters of Intent is now available on the CIPHER website. Early-stage investigators, who have completed their terminal research degree within the past 10 years and who serve for the first time as primary PI for a non-training research grant, are eligible to apply. Proposals for research projects with the potential to contribute to the optimization of HIV diagnosis, prevention, treatment and care for infants, children and adolescents affected by HIV in resource-limited settings by responding to identified research gaps (see list of eligible research topics) can be submitted by 26 November 2012.
Up to 10 research projects worth up to $75,000 per year for a maximum of two years will be awarded at the 7th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2013) in Kuala Lumpur, Malaysia, from 30 June to 3 July 2013.
CIPHER Research Grant Team
Avenue de France 23 | CH-1202 Geneva | Switzerland
Tel: +41 22 7100 843 | Fax: +41 22 7100 899
Email: cipher@iasociety.org
Web: www.iasociety.org
First issue of the defeatHIV Newsletter now available!
We're pleased to announce the publication of our inaugural defeatHIV Newsletter!
As we strive towards a cure, we hope this newsletter will keep both the public and scientific communities informed of our collaboratory operations and research efforts. Inside our first issue you will find an introduction to our collaboratory, an overview of our clinical studies and a look ahead to the November NIH-sponsored joint Martin Delaney Collaboratory meeting.
Visit our newsletter page to download, subscribe, and learn more about this exciting new publication!


text:
Abdur Rasheed Biswas (died 1991) was a Bangladeshi politician. He was elected as MP of Jessore-10 in the first general election of Bangladesh.

He lived in Khalia village of what is now Mohammadpur Upazila of Magura District. He died on 11 December 1991.

References

Awami League politicians
People from Magura District
1st Jatiya Sangsad members
1991 deaths

redpajama_set_name: RedPajamaWikipedia


If you see two blue check marks next to your sent message then the recipient has read your message. In a group chat or broadcast message, the check marks will turn blue when every participant has read your message.
If you want ti turn the blue marks off click here.


Love marriage specialist in Saudi Arabia :-Our love marriage specialist in Saudi Arabia is stated that marriage which is considered as one of the most beautiful phases of everyone's life. It brings several memories and blessings in the form of together way. Marriage is basically a formation of new relationship where two people start a new life in the form of together ways or condition. At one place where love marriage is accepted happily, it is considered as a sign on sin in other parts of the world.Love marriage specialist in Saudi Arabia . He is a well renowned name in the field of astrology. He has been providing astrology solutions to a wide range of problems from past few years. If you have lost your love there is facing several problems in love marriage or there is struggling hard to get rid of marriage problems.
Love marriage specialist in Saudi Arabia :-Marriage is a very delicate thing and problems in love marriage which will not harm your life but the life of your children, family members and everybody who is emotionally attached to it. Our love marriage specialist in Saudi Arabia is stated that he can help you in solving all of the problems of your love marriage life. He has tantras and mantras that are expedient and he is known for helping people in their love marriage. A time comes when people want to give up on their marriage and that time there is need to take help of specialist of love marriage. He understands all the sources from where problems can be generated and he works towards eliminating them.
There are many love marriage tend to dissolve this is because lack of compromise. Compromise which has to be done mutually and not alone by any one being that is even family at some point there is need to compromise. Thus people should marry only when they are sure about each other which are willingly agreeing to the changes it will get with itself. While many times it so happens that two people, they are in love and they are not able to handle the pressure of love marriage in Saudi Arabia but these are handled by the Love marriage specialist in Saudi Arabia .


text:
Q: vue.js: highlight in HTML a new object in javascript array I am using a table which renders a collection of items.
Whenever I add a new item to the collection, I would like to highlight the new item in the table for the user for 1 second.
How do I access the new object from a .vue file and change its background color for 1 second?
This is my code for adding the new object:
var indicator = this.tableIndicators.find(x => x.id === indicatorId)
var indicatorIndex = this.tableIndicators.findIndex(x => x.id == indicatorId);
this.tableIndicators.splice(indicatorIndex, 1); //remove indicator from indicators collection
this.tableData.unshift(indicator); // add indicator to table-data

A: Following @Stepehn's link, this solved my question 'List Entering/Leaving Transitions':
https://v2.vuejs.org/v2/guide/transitions.html#List-Entering-Leaving-Transitions

redpajama_set_name: RedPajamaStackExchange


text:
O hac
ВСЕМИРНЫЙ ВОДНЫЙ ФОРУМ
Human rights to water and sanitation project: invitation to members to participate
Опубликовано 28 августа 2017
In line with the relentless effort to engage policy makers into a political discussion to raise the profile of the Human Rights to Water and to Sanitation, the World Water Council recently started a project entitled "The Human Rights to Water and to Sanitation: Overcoming challenges to implementation".
The project will update the influential paper 'The Right to Water: from concept to implementation' that the Council launched in 2006 and that contributed to garnering strong support for recognition of the right to water as a fundamental human right in 2010.
Water and sanitation have always been a priority on the Council's agenda. Since the early 2000s, the Council has campaigned widely for recognition of the Human Rights to Water and Sanitation and has striven for their implementation, with the intent of placing the Human Rights at the top of the international agenda and at the center of the political discussion, advocating for water and sanitation to be provided to the billions without.
The new program aims at assessing the actual status of the Human Rights to Water and Sanitation, with a special focus on the latter while identifying barriers to their implementation and how to overcome them. A publication is expected to be launched at the 8th World Water Forum.
The work will be developed with the support of a Multi-Stakeholder Group of organizations that have expertise in human right to water and sanitation issues, who will actively contribute to the project.
The World Water Council welcomes the enthusiastic participation and interest of all its Members in contributing to the project and be part of the Multi-Stakeholder Consultation Group.
Группа высокого уровня решает вопрос финансирования водохозяйственной инфраструктуры
The first meeting of the High Level Pane
Access to water and sanitation: a priority for African local authorities
Dakar, Sénégal, 4-8 December 2012 – The
President Braga to serve a second term
14 November 2015 - Marseille, France – B
Email: wwc@worldwatercouncil.org


Description: Solidly built and easy to handle by one or two persons, Hopalong is a Ron Holland-design and is equipped to take you cruising or live-aboard. All control lines lead aft to cockpit. To tack, just turn the wheel on this free-standing rig. No hassle with other control lines. Sails are like new, in excellent condition and fully battened. Great headroom, 6 feet, 4 inches. This is a terrific boat, speedy, comfortable and liveable.
Freedom Yachts were featured in Ferenc Mate's book, "The World's Best Sailboats." Known for their solid construction, they were built by Tillotson-Pearson in Rhode Island.
Age is forcing the owners to sell.
Equipment: Alpha below-decks autopilot, Monitor windvane, watermaker, SSB, radar, 45-pound and 36-pound CQR anchors, 300-feet, 5/16 high test anchor chain, Achilles inflatable and five-horsepower outboard, staysails to fly off mizzen mast, four solar panels, EPIRB, 70-gallon fuel capacity in two tanks, 120-gallon water capacity in two tanks and much, much more. Email delightfulsailing@gmail.com for full description,specs and more photos.
Equipment: Five pages of equipment and specifications are available by emailing delightfulsailing@gmail.com. Also available are a full range of photos.


Search - Why Fight Alone?
A few years ago, I was driving to work when a drunk driver smashed into my car. Although I thought that the case would be relatively cut and dry, I quickly discovered that the insurance company was blaming me for the problem. After weeks of trying to argue my case, I realized that I needed a little help. I talked with a lawyer who took my case, and I can't begin to tell you how much of a difference it made. My lawyer walked me through the process, fought my battles in court, and got me enough money to pay for all of my outstanding medical expenses. My website is dedicated to helping innocent people reclaim their lives by working with attorneys.


There are numerous benefits if you compare the composite material to normal plastics. To name a few, they have better heat endurance and a better durability thanks to their stiff structure. They also allow the use of engraving techniques. If you compare the natural fibre composites to wood, the most important benefit is that the composite does not require maintenance. Also, it does not "absorb" smells and it is insensitive to humidity.
KUPILKA products are also recyclable and can be returned to normal plastic recycling centres or grinded and casted again into new products at the end of their life span. All KUPILKA packages & label cards are made from recycled cardboard. The string of KUPILKA 5 is made from reindeer leather.
The material was developed by Puugia, the Centre for Wood Technology in Joensuu, Finland. The material as well as the KUPILKA products are manufactured by Plasthill Oy in the same region of North Karelia.


text:
{{Соревнование по кёрлингу
|название           = Чемпионат Новой Зеландии по кёрлингу среди женщин
|ориг_название      = New Zealand Women's Curling Championship 2017
|год                = 2017
|года               =
|изображение        =
|подпись            =
|размер             = 150px
|город              = Данидин
|арена              = Dunedin Ice Stadium
|дата               = 7—9 июля 2017
|посещаемость       =
|победитель         = Бриджет Бекер
|победители         =
|титул              = 8
|победитель мужчины =
|титулМ             =
|кёрлинг клуб       =
|скип               =
|четвертый          = Бриджет Бекер
|третий             = Jessica Smith
|второй             = Holly Thompson
|первый             = Emma Sutherland
|запасной           =
|тренер             =
|мужской            =
|женский            =
|финалист           = Chelsea Farley
|победитель женщины =
|титулЖ             =
|кёрлинг клуб2      =
|скип2              =
|четвертый2         =
|третий2            =
|второй2            =
|первый2            =
|запасной2          =
|тренер2            =
|финалист2          =
|3е место           = Мэйри-Бронте Данкан
|пред               =
|след               =
}}Чемпионат Новой Зеландии по кёрлингу среди женщин 2017 проводился с 7 по 9 июля 2017 в городе Данидин на арене «Dunedin Ice Stadium».

В чемпионате принимало участие 3 команды.

Победителями чемпионата стала команда скипа Бриджет Бекер (Бриджет Бекер как скип стала чемпионом среди женщин в 8-й раз, как игрок — также в 8-й), победившая в финале команду скипа Chelsea Farley. Бронзовые медали завоевала команда скипа Мэйри-Бронте Данкан.

Одновременно и там же проходил Чемпионат Новой Зеландии по кёрлингу среди мужчин 2017.

 Формат соревнований
На первом, групповом этапе команды играют между собой по круговой системе в два круга. При равенстве количества побед у двух команд они ранжируются между собой по результату личной встречи, при равенстве количества побед у трёх или более команд — по результатам суммы тестовых бросков в дом (, в сантиметрах; чем меньше величина, тем выше место команды). Две лучшие команды выходят во второй этап, плей-офф, где играют в финале.

 Составы команд

(скипы''' выделены полужирным шрифтом)

Групповой этап
{| class="wikitable" border=1 cellpadding=5 cellspacing=0 style="text-align:center;
!
!Команда
!width=20|1
!width=20|2
!width=20|3
!width="20"|
!width="20"|
!width="30"| , см
!Место
|- bgcolor=#cfc
|1||align=left|Бриджет Бекер       ||          * || 4:7 8:1|| 3:6 7:4|| 2 || 2 ||  ||2
|-
|2||align=left|Мэйри-Бронте Данкан || 7:4 1:8||          * ||1:10 2:5|| 1 || 3 ||  ||3
|- bgcolor=#cfc
|3||align=left|Chelsea Farley      || 6:3 4:7||10:1 5:2||          * || 3 || 1 ||  ||1
|}
 команды, выходящие в финал плей-офф

 Плей-офф Финал.' 10 июля, 13:00''

Итоговая классификация

Примечания

См. также
 Чемпионат Новой Зеландии по кёрлингу среди мужчин 2017
 Чемпионат Новой Зеландии по кёрлингу среди смешанных команд 2017
 Чемпионат Новой Зеландии по кёрлингу среди смешанных пар 2017

Спорт в Новой Зеландии в 2017 году
Чемпионаты Новой Зеландии по кёрлингу среди женщин
Спортивные соревнования в Данидине
Июль 2017 года


text:
Caterina Fake is an American entrepreneur and businesswoman. She co-founded the websites Flickr in 2004 and Hunch in 2007. Fake has been a trustee for nonprofit organizations and was the chairwoman of Etsy. For her role in creating Flickr, Fake was listed in Time magazine's Time 100, and she has been recognized within Silicon Valley for her work as an angel investor.

Early life and education
Fake was raised in northern New Jersey by her American father and her Filipina mother. As a child, she was not allowed to watch television, and her hobbies included reading poetry and playing classical music.

She graduated from the prestigious Choate Rosemary Hall in 1986 and Vassar College in 1991 with a degree in English, after transferring from Smith College in 1989. Vassar College had an intranet that the students could connect to from their dorm rooms, which Fake credits as being largely responsible for her eventually finding web design. After working various jobs, including as a painter's assistant, an investment banker, and at a dive shop (which Fake called her "post-college what-do-I-want-to-do period"), she was delayed in San Francisco while visiting her sister. Fake taught herself about the Internet and began creating websites and CD-ROMs.

Career
In 1997, she took a job managing the community forums of Netscape. This experience, along with others in blogging and online communities, led her to co-found Ludicorp in Vancouver with Stewart Butterfield and Jason Classon in summer 2002. The company developed a massively multiplayer online role-playing game called Game Neverending. The game did not launch, but Fake and Butterfield started a new product called Flickr in 2004 that became one of the world's most popular photosharing websites. Flickr was acquired by Yahoo! in 2005 for around US$30 million. It became part of the "Web 2.0" sites, integrating features such as social networking, community open APIs, tagging, and algorithms that surfaced the most popular content. After the acquisition, Fake took a job at Yahoo, where she ran the Technology Development group, known for its Hack Yahoo program and for Brickhouse, a rapid development environment for new products. She resigned from Yahoo on June 13, 2008.

Fake previously worked as the art director for Salon, a news and opinion website started in 1995. In 2007, she co-founded the website Hunch with entrepreneur Chris Dixon, which was acquired by eBay for $80 million in November 2011. As of 2014, Fake's most recent project is called Findery. It launched under limited beta in February 2012 and was originally called Pinwheel. It was renamed to Findery in July 2012. The company is headquartered in San Francisco.

Fake joined the board of directors of Creative Commons in August 2008, and the Sundance Institute board of trustees in 2015. In 2014, she left Etsy's board of directors after eight years, citing other professional and personal priorities. She was chairwoman at the time of her resignation.

Fake has won various awards, including Bloomberg Businessweek's "Best Leaders" in 2005, Forbes's 2005 eGang, Fast Company's Fast 50, and Red Herring's 20 Entrepreneurs under 35. She was listed on the 2006 Time 100—Time magazine's list of the world's 100 most influential people—under the category "Builders and Titans" with her Flickr co-founder. She received honorary doctorates from the Rhode Island School of Design in 2009 and from The New School in 2013. Fake was a recipient of the 2018 "Visionary Award" from the Silicon Valley Forum, which recognizes leaders in Silicon Valley businesses. Among her most recognized businesses, she was identified for her contributions to Silicon Valley as an author and angel investor.

Fake hosted the podcast "Should This Exist?" produced by Quartz.

Personal life
Fake was married to Stewart Butterfield, her Flickr co-founder, from 2001 to 2007. They had one daughter together, in 2007. As of 2015, Fake is in a relationship with Jaiku co-founder Jyri Engeström, and the couple have three children between them.

Notes

References

External links

1969 births
20th-century American businesspeople
20th-century American businesswomen
21st-century American businesspeople
21st-century American businesswomen
American people of Filipino descent
American corporate directors
American technology chief executives
American technology company founders
American women chief executives
Businesspeople from California
Businesspeople from New York City
Businesspeople from Pittsburgh
Businesspeople in information technology
Canadian technology company founders
Choate Rosemary Hall alumni
Living people
Members of the Creative Commons board of directors
Smith College alumni
Vassar College alumni
American women company founders
American company founders


We believe the MAP 3/4 Length Waterproof Jacket is the best 3-layer jacket in the market. The fabric has an exceptionally waterproof membrane that delivers 20,000mm Hydrostatic Head rating. In addition, the fabric has a DWR finish for added protection. The membrane combined with a nylon face and 2% spandex means that this jacket is extremely durable and comfortable when worn. ItÔÇÖs a solid and reliable jacket for spending an extended length of time in the outdoors. There are no surprises with the fit. The sizing is generous and designed to be worn with undergarments such as hoodies, so it can be worn comfortably as part of a layering system. A longer jacket length combines with a dropped, adjustable hem. The large hand pockets have water resistant zips to avoid unnecessary bulk. The hood can be cinched in and a stiffened peak means that the hood will keep its shape even in torrential rain. When not in use the hood can be folded away into the collar. The double cuff construction delivers a closer fit. A neoprene inner cuff under the adjustable fabric outer cuff ensures that the cuff remains watertight.


text:
Tuesday, September 04, 2012 ... / /
Pascual Jordan and foundations of QM
Update: See also this written text by Don Howard about Jordan's 1936 "intuitive quantum mechanics" book. It's the same Howard who speaks in a video below. Some keywords: anti-Marxist, positivism, stuttering, vitalism, telepathy, Vienna Circle, defense of Jewish physicists
Among the fathers of quantum mechanics, Pascual Jordan is the least well-known one. Needless to say, politics is the single most important reason behind his invisibility although it is not necessarily the only one.
While he genuinely believed in the ideals of the NSDAP that he joined at some moment (not to speak about Luftwaffe and the Peenemünde rocket center where he worked as a climate scientist), he was pretty much suppressed already in the 1930s. After all, he was also unreliable for the regime due to his past collaboration with Jews such as Max Born and Wolfgang Pauli.
Mostly for political reasons, he became isolated from the research community already around 1930. But after the war, some fellow physicists declared him "rehabilitated", he became a tenured professor again, and he was also elected as a lawmaker for the most mainstream among German parties, CDU. Nevertheless, he had done pretty much all the important original technical contributions to physics before 1930 or so.
(Well, it's not quite fair because he would work on general relativity and its extensions – and on cosmology – after the war. He even worked on Kaluza-Klein theory where he realized that the 4D Newton's constant depends on the radius of the fifth dimension – surely a key insight that was heavily exploited e.g. by Arkani-Hamed, Dvali, and Dimopoulos, among many others. In 1961, together with Jürgen Ehlers, he developed the kinematic decomposition of a timelike congruence. Jordan also independently discovered or invented the Brans-Dicke theory, rarely called the JBD theory because it isn't politically correct, either.)
When it comes to science and philosophy, it's therefore much more interesting to focus on the 1920s when he was a major determinant of the evolution of physics and the 1930s when he was a maximally competent person to summarize the state of the affairs. I just watched a pretty fascinating 35-minute 2010 lecture by Don Howard, a historian and philosopher of science at Notre Dame:
Quantum Mechanics in Context: Pascual Jordan's 1936 Anschauliche Quantentheorie in its Philosophical and Political Setting (35 minute video, main link of this blog entry)
Most of the talk is dedicated to an analysis of Anschauliche Quantentheorie, his 1936 textbook on quantum mechanics that covered everything from the philosophical foundations of quantum mechanics to the "completed" status of non-relativistic quantum mechanics and to the state-of-the-art quantum field theory and nuclear physics at that time (which was still confusing and incomplete but whose birth was partly Jordan's work, too).
Howard's talk makes it look like it was an excellent text. Too bad it doesn't seem to be translated into English, a fact that has most likely political reasons as well. Maybe this suppression of the once-successful textbook – or perhaps some people's emotional desire to deliberately contradict it – is one of the major historical reasons why quantum mechanics remains so heavily misunderstood today.
The title of the book means something like "Lively/Imaginative Quantum Mechanics" and it deliberately emulates the title "Anschauliche Geometrie" by David Hilbert and Stephan Cohn-Vossen, an important book that was translated to English under the title "Geometry and the Imagination". Jordan, a fan of Hilbert, really meant to "do the same thing" as Hilbert for quantum mechanics.
Concerning research contributions, Jordan previously co-developed matrix quantum mechanics in the mid 1920s together with (his adviser) Max Born and partly in collaboration with Werner Heisenberg. He should have arguably shared the 1954 physics Nobel prize but he was probably erased because of his politics. He has invented the Jordan algebras but their utility in quantum mechanics was later found to be very limited – while pure mathematicians began to use them in other contexts.
Back to the book
But let's return to the mid 1930s and his book on quantum mechanics. Howard argues that Jordan knew very well what his philosophical roots were. It was a particular combination of traditions and emerging movements and this combination makes a lot of sense, at least up to some point.
He would endorse Ernst Mach's logical positivism (which would also inspire the creation of the Vienna Circle, a philosophical club that Jordan de facto belonged to and that used to be called the Ernst Mach Society) as well as David Hilbert's finitism in mathematics and he would argue that they're pretty much the same thing and quantum mechanics as associated with the names of Bohr and Heisenberg is showing that the same principles hold in microscopic physics, too. Well, he didn't hide that he considered himself (and Paul Dirac) to be the actual fathers of Bohr's complementarity, anyway.
Now, one must be careful about philosophies and excessive generalizations. Mindless generalization may lead you to very wrong conclusions. If a philosophy or a vague idea works in one class of questions, it doesn't necessarily work for all other questions. And indeed, I think that Jordan's vitalism ("living things are different from non-living things" and therefore "biology is more fundamental and physics is its special case"; and he even wrote positive things about telepathy!) may be an artifact of a philosophy that was extrapolated too far and too mindlessly.
However, at the level of foundations of quantum mechanics, his combined philosophy seems completely coherent and meaningful to me. Ernst Mach would emphasize that one shouldn't talk about the data we can't experimentally extract, not even in principle. Of course, Mach was far from understanding quantum mechanics but I think it is very fair to say that quantum mechanics confirmed that Mach's warnings were very important.
Jordan would also endorse Hilbert's finitism in mathematics – the idea that only objects we can completely construct exist. This is a legitimate – and perhaps my preferred – attitude to various dilemmas in set theory. Is the Axiom of Choice true? We know that we may create consistent axiomatic systems with the Axiom of Choice as well as ones with its negation. Using the finitist logic, the reason behind this ambiguity is that the only real numbers (and other objects) that "really inevitably exist" are those that may be exactly described by a finite sequence of steps or conditions. So even the proposition that the number of real numbers exceeds the number of integers shouldn't be viewed as a statement about the "actual real numbers that are out there"; instead, it is a statement about the non-existence of an "actual map" (again, fully specified by finitely many symbols) matching real numbers to integers.
The finitist philosophy indeed seems very analogous – and from a broader viewpoint, "equivalent" (as long as it makes any sense to talk about the equivalence between principles in mathematics and principles in physics) – to the logical positivism because it urges you not to think about things that objectively exist – like arbitrarily contrived real numbers or the values of observables in QM prior to the measurement – and instead, to focus on the finite propositions you can make and the most general methods you may design to find out which of them are true and which of them are false.
Howard concludes that the unifying element of all themes in Jordan's book is his opposition to materialism so in some sense, all his efforts were ideologically driven. Even though I would sometimes count myself as a materialist and I dislike research that is ideologically driven, he probably had something to say. I haven't really read the book but I would love to. ;-)
Vystavil Luboš Motl v 5:40 PM | |
Other texts on similar topics: philosophy of science, politics, quantum foundations, science and society
snail feedback (9) :
reader Dilaton said...
Nice article, Pascual Jordan has obviously done some cool things for physics :-D
Maybe his QM book can be traslated to English these days ... @Eugene S ... :-P ;-) :-) ?
Sep 4, 2012, 10:39:00 PM ...
reader Robbie said...
Interesting article. Thanks Lubos.
Something that might interest your friend Tom: Jordan had a very severe stutter. According to a book by Sheila Jones ("The Quantum Ten"), Jordan was not invited to the 5th Solvay Conference. Jones speculates that this was due to his stutter, which would have made public speaking "a trial for both him and his audience".
Sep 5, 2012, 1:55:00 AM ...
reader Peter F. said...
We were told Jordan was deeply religious; So, that was surely an important aspect of his (largely covert as matter of course} agenda.
P.S. It is also possible to have an agenda driven by chronic irritations and frustrations and shaped by everything one knows about religiosities and similar things. ;-^
reader Luke Lea said...
He looks like Mr. Bean.
reader anon said...
Certainly concur that one should avoid ideological biases when engaging in physics, certainly Jordan's political choices were horrible and worthy of contempt. I would however argue that there is evidence that much of our understanding of physics is derived from personality, which reinforces the position that objectivity can only be understood as emergent as one analyzes mutual information. It isn't that there are invariant quantities that pre-exist for our discovery, but that invariant quantities emerge because of a certain irreducibility in the mathematics when things are not perfectly independent or exclusive.
reader physicsnut said...
Thanks. There was also an article on a similar subject on ArXiv 1204.6511 by Duncan and Janssen - about Jordan and Dirac, and von Neumann.
I think Schweber mentioned that it was Jordan who introduced Pauli to quaternion algebra. Just represent it with 2x2 complex matrices and, voila, one can couple the spin up and spin down. It sounds like a good thing Jordan was hanging around the mathematicians, otherwise it might have taken a lot more time to make sense of Spin.
Sep 5, 2012, 3:53:00 PM ...
Interesting article Lubos, you must know that George Ellis is attacking quantum physics and all of physics with his bizarre hypothesis of top-down causality.
http://fqxi.org/community/forum/topic/1337
This is part of the abstract: "One of the basic assumptions implicit in the way physics is usually done is that all causation flows in a bottom up fashion, from micro to macro scales. However this is wrong... Understanding the emergence of genuine complexity out of the underlying physics depends on recognising this kind of causation. It is a missing ingredient in present day theory"
reader Ehab said...
Is this book about aspects of QM in biology real science or scam?
http://www.amazon.com/Quantum-Evolution-Weirdest-Explains-Paperback/dp/0393323102/ref=sr_1_12?s=books&ie=UTF8&qid=1347074130&sr=1-12&keywords=quantum+aspect
reader Casper said...
Jordan seems to have been the inspiration for the film version of Nazi mad scientist Dr. Arnim Zola, the henchman of Johann Schmidt in Captain America. They look completely identical.
In order to understand the lecture I had to look up big words like positivism and materialism, but generally speaking they seem to be fancy names for normal everyday items which was a relief.
Its difficult to get any idea from the lecture of what Jordan's neo-vitalism was all about, but its clear that he was an incipient paranormalist. Clearly a perceptive man a century ahead of his time!
Sep 12, 2012, 2:25:00 PM ...
Gore's investment firm: no green investments
Raphael Bousso is right about firewalls
President Klaus survives "assassination attempt"
Exotic branes, U-branes, and U-folds
Fifty years after Silent Spring
Experimenters, SUSY, frustrations, and anthropic i...
Albert Einstein 1911-12, 1922-23
Street View: Antarctica, deep ocean, Alps, Mars, etc.
Witten's new trilogy on RNS diagrams
BBC: Who's afraid of a big black hole?
Did EPA test toxins on humans?
Almost all particle physics papers will be free
BBC: How small is the universe?
Are black holes surrounded by firewalls?
EU carbon market will be saved by a new boom of coal
Klaus in Telegraph: on final stages of destruction...
Australia: qubit as a single silicon atom
Chu and CMS' Incandela's DOE Higgs talk
German biogeochemistry postdoc proposes to extingu...
May the name legitimately influence the fate of an...
Insane reaction to the PBS interview with Anthony ...
Thomson Reuters bets on teleported higgsless Nobel
Astronomical unit (AU) redefined
The West is nearly apologizing to hordes of bloodt...
Smileys: 30 years
Stringy boundary conditions and D-branes
Michio Kaku: physicists invented everything
Innocence of Muslims: watch HD here
Japanese guy may have proved the \(abc\) conjecture
Vafa's new 4D string theory
Barroso wants a European Federation
Official Iranian media promote truthism
PLB publishes Higgs discovery papers
I probably suffer serious illness
Stephan Lewandowsky's incredible blog
Pseudoscience hiding behind "weak measurements"
Klaus: West is, disappointingly, returning to soci...
Science debate, 14 questions: Romney beats Obama
WISE finds millions of black holes, thousands of h...
Sunlight or neutrinos affect the radon gamma decay...
Stratospheric geoengineering: undoing global warmi...


Rechargeable batteries save you money as you do not have to dispose of them after use. All you have to do is to recharge them and place them back to work.
They had been the first components to get into the marketplace. While they're great since they load quickly and perform excellently in cold environments, their main defect is they suffer from memory effect. Whenever you do not fully charge them they lose their ability. You can go around this problem by executing it level before repainting them.
Because of the inclusion of cadmium, the components are not the most eco-friendly in the marketplace. When they die, you need to dispose of them properly to avoid damaging the environment and your family members.
These are more economical and do not contain toxic heavy metals. Unlike their cadmium counterparts, they are not impacted by memory effect so you do not have to run them level before recharging them. You need to note that they may get ruined if you do not recharge them for a long time. To prolong their life, then recharge them when they arrive down.
They're the most costly on the marketplace and come in various shapes and sizes so that you are able to locate the ones that match from digital cameras into mobile phones. While they are costly, they're extremely eco-friendly as don't possess damaging components.
A couple of things you ought to know about the batteries.
The batteries have a lifespan!
Even though they're rechargeables thus survive their disposable counterparts, these components have a lifespan just like every other component in the entire world. The lifespan varies depending on the standard and how well you look after them. By way of example, whenever you store the components in high temperature, then they'll get ruined fast than whenever you set them in a cool environment.
When the components die, dispose of them properly to avoid difficulties. They contain heavy metals which could be volatile or flammable. To guard your property avoids burning, puncturing, or removing it. The best means of disposing of them is taking them into a business devoted to recycling them.
This is what you need to know about rechargeable batteries. For them to last for long and give you a fantastic provider, purchase them from a respectable store.


OK, where have I been?
Every Sunday night, I'd think to write up a new blog post. Just a few paragraphs on what's been going on with me. But then I'd start doing something around the house, or I'd get home late from being away all weekend, or I'd just get too tired, and then there goes another week without a post.
I checked, and my last entry is on May 20. May 20?!?! That was before summer even started! Wow.
Yep, we bought our first house!
I didn't blog about it (I didn't want to jinx anything) because we've been looking for a house since January 2012! That's almost 17 months to find the house, and an extra 2 to close. So all totaled, we've put in about 19 months for this process. Unbelievable. But, you live, you learn.
Would I do things differently if I had to go back? Absolutely, but I'm very happy with our purchase, and look forward to many years in our new home.
Robin's egg blue toilet (with matching sink and tub), check.
I hope you'll stick with me on this exciting new journey.