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COVID 19 SOLUTION CHALLENGE
by JagmOHaN Singh Sekhon March 27, 2020
COVID 19 THREE PRONGED SOLUTION CHALLENGE
THREE PRONGED STRATEGY TO A SOLUTION
We have been doing an extensive research on the current Coronavirus SARS-CoV-2 (2019-nCoV) and the interventions that need be taken. On the basis of our findings, we are pushing forward a three pronged solution.
A. Vaccine.
B. Strengthening the innate and adaptive immune systems.
C. Testing
A. Vaccine — We shall divide this into 2 parts .
1. Actions on the virus side.
2. Actions on the human cells side.
1. Virus Side Actions
a. Coronavirus Family Code
i. Coronaviruses contain a genome composed of a long RNA strand (SARS-CoV-2 is about 30,000 nucleotides long) one of the largest of all RNA viruses. This genome acts just like a messenger RNA when it infects a cell, and directs the synthesis of two long polyproteins that include the machinery that the virus needs to replicate new viruses. These proteins include a replication/transcription complex that makes more RNA, several structural proteins called viroporine that construct new virions, and two proteases. The proteases play essential roles in cutting the polyproteins into all of these functional pieces.
ii. Thus coronavirus is limited to just 2 following subunits and both can be attacked to stop it.
1. The protease exterior
2. The lengthy stand of RNA which serves as the viruses' genetic material
iii. Actions on Protease :
1. The protease's activity is triggered by the binding of molecules to specific points on the protease called active sites. The binding of a substrate effectively switches the protease on, allowing it to cut the long viral protein strands into smaller chains. The protease's activity can also be blocked by molecules called inhibitors. When an inhibitor attaches to an active site, it prevents the binding of substrates stopping the action of the protease altogether. Therefore, finding an inhibitor for COVID-19's heart-shaped protease is the first step to beating the epidemic which is what the current research and trials being conducted is all about.
2. Current effort to save time are more towards repurposing existing antiviral drugs as protease inhibitors. WHO is focusing on what it says are the four most promising therapies:
a. An experimental antiviral compound called remdesivir;
b. The malaria medications chloroquine and hydroxychloroquine;
c. A combination of two HIV drugs, lopinavir and ritonavir;
d. And that same combination plus interferon-beta, an immune system messenger that can help cripple viruses.
3. Some data on their use in COVID-19 patients have already emerged — the HIV combo failed in a small study in China — but WHO believes a large trial with a greater variety of patients is warranted.
iv. Actions on RNA — Using CRISPER enzyme CAS13
1. The COVID-19 public health emergency is due to a coronavirus, which contains an RNA — not DNA — genome.
2. Researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center and New York University have developed a new kind of CRISPR screen technology to target RNA.
3. Cas13 enzymes are Type VI CRISPR (clustered regularly interspaced short palindromic repeats) enzymes that have recently been identified as programmable RNA-guided, RNA-targeting proteins with nuclease activity that allows for target gene knockdown without altering the genome.
4. This property makes Cas13 a potentially significant therapeutic for influencing gene expression without permanently altering genome sequence.
5. Using the model derived from their massively-parallel screens, optimally guided RNAs can help detection and therapeutic applications.
v. Challenges
a. Diversity of the Coronavirus :
i. Diversity of coronaviruses poses a great challenge with this as the proteases of these viruses can be very different. So drugs designed to fight one may not be effective against others.
b. Mutation :
i. SARS-CoV-2, is believed to have 2 "strains": the "L" type and the "S" out of which "L" type, is deemed to be more aggressive type and found in 70% of the virus samples. But its prevalence decreased after early January. The more commonly found type today is the older, "S" type, because "human intervention" such as quarantines may have reduced the ability of the "L" type to spread. For one thing, the mutations are incredibly small on the order of a couple of nucleotides, the basic building blocks of genes. (SARS-CoV-2 is about 30,000 nucleotides long). These slight changes likely wouldn't have a major impact, if any at all, on the functioning of the virus, so it would be "inaccurate" to say that these differences mean there are different strains. These viruses are still so genetically similar that these mutations shouldn't alter a new vaccine. Once the vaccine is out, however, the virus could adapt to it and develop resistance, but considering that other RNA viruses such as those that cause measles, mumps and yellow fever didn't develop resistance to vaccines, that scenario is unlikely.
2. Human Cells Side Actions :
a. Coronaviruses both the SARS coronavirus of 2003 and the novel coronavirus of 2019/20 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming.
b. The spike glycoproteins have two subunits; one subunit, S1, binds to the receptors on the cell surface; the other subunit, S2, fuses with the cell membrane. A host transmembrane serine protease, TMPRSS2, promotes entry of SARS-Cov into cells by two separate mechanisms. After the S1 subunit of the spike binds to the ACE-2 enzyme on the cell membrane surface, TMPRSS2 activates the spike and cleaves ACE-2. TMPRSS2 also acts on the S2 subunit of the spike glycoprotein, causing an irreversible conformational change, activating it, and facilitating fusion of the virus to the cell membrane. The virus then enters the cell.
c. Actions on ACE2 side
i. The receptor for the SARS cough virus that causes COVID19 is the ACE2 receptor. The virus enters the body through the nose, mouth or eyes, then attaches to cells in the airway GI tract that produce a protein called ACE2 which is where the s protein docks. Then there's another protein called a serine protease TMPRSS2 which is also here in the membrane which helps to internalize this virus into the cell and it allows the messenger RNA which is in here to come in and infect the cell. This protein on the human cell side is exactly the same protein that was the receptor for the SARS. Treatment with an anti ACE-2 antibody can block entry of SARS-CoV-2 expressing S protein.
ii. The ACE 1 and ARB inhibitors used for the treatment of blood pressure and cardiac diseases are being talked about of increasing the ACE2 receptors but there is no evidence so far.
iii. Janus-associated kinase (JAK) inhibitor Olumiant (baricitinib), approved for rheumatoid arthritis, was identified using machine learning algorithms on the basis of its inhibition of ACE2-mediated endocytosis.
iv Another JAK inhibitor, Jakafi (ruxolitinib), is in trials (combined with mesenchymal stem cell infusion) for ACE2.
d. Actions on TMPRSS2 side
i. SARS-CoV-2 requires the protease TMPRSS2, which is present in the human body, to enter cells. This protease is a potential target for therapeutic intervention if blocked by an inhibitor. Since it is known that the drug camostat mesilate inhibits the protease TMPRSS2, research is going on here to whether this inhibition can also prevent infection with SARS-CoV-2.
e. Actions On Other Methods : Sera from recovering SARS patients reduced SARS-CoV-2 S protein-driven entry into Vero-E6 cells. Different Covalescent Blood Produtcs (CBP) being tried to achieve artificially acquired passive immunity include all of the following
1. Convalescent whole blood (CWB), convalescent plasma (CP) or convalescent serum (CS);
2. Pooled human immunoglobulin (Ig) for intravenous or intramuscular administration;
3. High-titre human Ig;
4. Polyclonal or monoclonal antibodies.
5. A future vaccine could help the body produce antibodies that target the SARS-CoV-2 virus and prevent it from infecting human cells. The flu vaccine works in a similar way, but antibodies generated from a flu vaccine do not protect against coronavirus.
3. Strengthening the innate and adaptive immune systems.
a. Learning's from SARS Proteases
i. The SARS-COV2 proteases while cutting the polyproteins also clips several proteins in the infected cell, including removing ubiquitin from ubiquitinated proteins. One of the consequences of this deubiquitination is that it interferes with production of interferons in the innate immune system, short-circuiting some of our defenses against the virus.
ii. Because the interferon system ( communication system between our innate and adaptive immune system ) is compromised, the adaptive system cannot be put to work.
b. Understanding Current Model Of Immune System Beyond The Old Two Box Model Immune System : We have four parts to the new model of immune system away from the old two box model.
i. Innate immune system which then integrates with the
ii. Adaptive immune system to create antibodies.
1. Innate Immune Stem
The innate immune system is that aspect of our body at the physical level, organ level all the way down to the cellular level that interacts with these pathogens that come from the outside — through our eyes, right through our mucosa in our nose, through our mouth, through our ears, through our skin and other orifices of our body. This is where these pathogens when they come, first interact with what is called as our innate immune system. This includes things like neutrophils and macrophages. The goal of innate immune system is to knock things out quickly and if things are working right it happens during the first few hours when we are experiencing some pathogens and thereafter what happens is the adaptive immune system kicks in.
2. Adaptive Immune System
a. The adaptive immune system include T cells and B cells which attempt to take out that particular pathogens by creating a particular antibody.
b. In a healthy individual the innate kicks in first and we don't even notice it. This may be a little sniffle that we get and don't feel that well and then adaptive kicks in and we create these antibodies and next time we are exposed to that particular pathogen we don't even notice that nothing really happens.
3. The Interferon System
The innate immune system communicates to the adaptive immune system and this interaction is through what is called as the interferon system. The interferon system regulates all sorts of genes to interfere with viruses. This means our body is expecting pathogens and it trains its stuff to get stronger. But these three systems are not alone there's a fourth system called the microbiome.
4. The Microbiome :
This system also includes what's called the biome which has trillions of viruses in our body. The microbiome is bacteria. For our six trillion cells, we have about ten times ie sixty trillion bacteria and then around three hundred sixty trillion viruses with a small number of fungi.
c. Viruses Don't Kill — The Compromised Immune System Does
1. Thus we already have hundreds of trillions of viruses in our body and tens of trillions of bacteria and all of these things are actually supporting life within us.
2. Viruses do not harm or kill us. It is the overreaction of a weakened and dysfunctional immune system to the virus that results in our own body attacking its own cells, tissues and organs.
3. Now these dysfunctional immune response is a result of underlying pre-existing conditions like Obesity, Diabetes, Heart disease which are because of Poor lifestyle, lack of sleep, poor dietary choices, lack of exercise, eating sugar, smoking people being immuno compromised.
4. Thyroid dis-functioning leading to our body not able to take carotenoids that we eat and convert them into vitamin A and we get less cytokeratins which create a wall around our cells to really protect us.
5. Lower HCL levels rising to lower our gut acidophilus due to which microbiome goes into dysfunction.
6. High sugar diet leading to candida and a whole other set of organisms that start growing leading to growth in glio toxins which destroy our macrophages and t-cells(innate and adaptive immune system).
d. Cytokine Storm :
1. Unable to help itself due to the broken immune system, the body while trying to heal itself against pathogens unleashes cytokine storm . All these other chemicals start raging to try to make up for the fact that the other subsystems have failed. When this cytokine storm happens, these chemicals go and start attacking our own tissues.
2. Now in corona it is our cytokine storm that attacks the epithelium which is a different set of cells in our lungs leading to ARDS ( Acquired Respiratory Distress Syndrome). The epithelial cells and mucosa and mucous tissue in integrity in our lungs, function as a front line of defense against pathogen and bae invasion. So when things are coming into us when someone with corona sneezes these pathogens come across the frontline defense which is our epithelial mucosa tissue.
3. Here Vitamin A plays a crucial role in the morphological formation of the epithelium epithelial keratinization stratification differentiation and functional maturation of the epithelial cells. Vitamin A is literally used to produce cytokeratins which are the building blocks protecting our cell walls and they're the ones who provide the border and in the epithelial cells of our lungs they're the ones who create the proper infrastructure so our body doesn't get attacked by these pathogens. So that's like the first defense system. Vitamin A is an integral part of the mucus layer of both the respiratory tract and our intestines. If we look at our grunt gut and our respiratory tract vitamin A is an integral part of that mucus layer and vitamin A promotes a mucus secretion it improves antigen nonspecific immunity of our innate and adaptive system so vitamin A is a hormone.
4. Vitamin A protects our cell walls but more importantly it also makes sure that our immune system is properly modulated and it down regulates those cytokines that will cause a cytokine storm that goes and attacks us.
5. A large percent of the people who test positive and die are on ventilators and they died with something called a ARDS.
6. ARDS is how corona virus kills it's not just the corona virus but many other viruses including the influenza virus that we have every year.
7. As described above the virus attacks the cells of the 600 million alveoli that human lungs have. The entire lungs become inflamed creating a large barrier. A fluid goes into the interstitial space. Furthermore the blood capillaries start to become leaky and fluid starts to leak into the alveolar space as well and this starts to fill up with proteinaceous liquid that prevents oxygen from getting into the bloodstream.
8. So instead of having nice oxygenated blood this blood becomes hypoxic and we become hypoxic. If we have ARDS and we have a hard time breathing and that's when we get placed on the ventilator.
9. We have to be supported on the ventilator so that we're getting enough oxygen and that the machine can breathe for us .
10. Another amazing nutrient from the Sun called vitamin D which produces chemicals which are antiviral is also important
11. So vitamin A, vitamin D and Vitamin C are major for the immunity and we can add more.
Thus we have to understand the above immune system holistically and then aggressively build immunity enhancement theureupatics to curtail infection at its source .
3. Testing Side : Following are the efforts going on.
a. RT-PCR :
When testing for a new virus like SARS-Cov-2, the first wave of diagnostics almost always relies on two important (though not particularly modern) technologies.
i. The first, PCR, or polymerase chain reaction, is a DNA amplification technique that is routinely used in the lab to turn tiny amounts of DNA into large enough quantities that they can be analyzed.
ii. But if scientists want to detect a virus like SARS-CoV-2, they first have to turn its genome, which is made of single-stranded RNA, into DNA. They do that with a handy enzyme called reverse-transcriptase. Combine the two techniques and you've got RT-PCR. Currently, RT-PCR is the only way to determine if a person has Covid-19.
iii. Starting in January, shortly after Chinese researchers released the first whole genome sequence of SARS-CoV-2, groups around the world began designing, testing, and publicly posting protocols for detecting the new coronavirus with RT-PCR. As a resource for testing labs, the World Health Organization has been keeping a list of these protocols, as well as guidelines for best practices. All countries experiencing their own outbreaks moved to adopt other protocols publicized by the WHO.
iv. Roche and Thermo Fisher, which recently had their in-clinic tests approved by the FDA, have been forced to reckon with supply chain issues that have limited their distribution.
b. Crispr-based diagnostics:
i. These tests use Crispr's programmable gene-seeking capabilities to deliver a diagnosis in under an hour without the need for fussy lab instruments.
ii. Startups like Sherlock Biosciences and Mammoth Biosciences are very active here. Mammoth published a preprint on March 10, describing a test the company developed for SARS-CoV-2 that works with paper test strips like those in a drugstore for pregnancy test. The company is currently in the process of further validating its initial results.
c. Serological Test
i. These tests look for antibodies to the virus in the blood of patients which would be useful, because in addition to identifying people with Covid-19, it could tell if someone was once infected but then recovered.
ii. Cheaper than PCR but not as accurate as molecular, this does detect SARS-COV-2.
d. Teleheatlth At Home tests
i. These are molecular point of care tests which companies are targeting to deliver a test in 30 minutes.
ii. A swab that's done too shallowly could wrongly convince someone that they don't have Covid-19.
iii. People getting a test result at home may react in unexpected ways compared with how they might handle the news where a clinician delivering it in-person.
iv. Nurx, Everlywell, LetsGetChecked, Carbon and few other startups had started home testing but FDA has declared that it has not prescribed any at home tests and hence those are stopped.
As we can see that the actions under the three pronged strategy will clearly lead to to reach the root cause and a solution to kill this virus forever.
We are in touch with various IITs in India and many institutes abroad are working on the above.
We intend to interact for solutions in vaccines , immunity and testing.
If you have one, reach out.
Back to News and Articles for the Billionaires


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Tim Roda
Tim Roda is a New York based artist. His art career began at the Pennsylvania State University, graduating in 2002 with a BFA. He achieved his MFA in 2004 from the University of Washington, Seattle. Roda's work travels within arenas of installation, photography, and performance. He was a resident artist at the Archie Bray Foundation in 2005, Marie Walsh Sharpe in 2006, and the Centro Cultural Andratx in 2008. He has received several awards, most notably a Fulbright Award in 2009 to Italy (Photography). In 2012, he received the Kennedy Family Fellowship at the University of South Florida, Tampa. Roda is represented by the following art galleries: tANJA gRUNERT gALLERY in New York City; Greg Kucera Gallery in Seattle, WA; Michael Jannsen, Berlin, Germany; and the Angell Gallery in Toronto, Canada. His work is in the following public and private collections; Bard College Museum, Hessel Foundation (New York, NY); The Rose Museum, Brandeis University (Waltham, MA); Seattle Art Museum and the Henry Art Museum (Seattle, WA); Museum of Fine Arts (Houston, TX); Elton John Collection; Museum of Contemporary Photography (Chicago, IL); Essl Museum, (Klosterneuburg Austria); Gaia Collection (Busca, Italy); and the Centro Cultural Andratx (Majorca).
Untitled #180
14.5 x 21"
edition #1/8
edition #AP/8
In My Brothers Name #201
edition #2/8 and #4/8 available
36 x 25.5"
Seattle Bound

redpajama_set_name: RedPajamaCommonCrawl


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Little Baby Bum (also known as LBB and LittleBabyBum) is a British children's CGI-animated web series created in 2011 by Cannis Holder and her husband, Derek Holder. The show revolves around Mia, a young girl, her family, peers and a group of anthropomorphic characters. The format of the show is 3D animated videos of both traditional nursery rhymes and original children's songs, but with a modern aesthetic, supporting child development of language through song and repetition. It was acquired by Moonbug Entertainment in 2018. The show is available on YouTube, BBC iPlayer, and distributed across SVOD and AVOD players, and over 40 platforms including Netflix, Amazon Prime, and Hulu. Little Baby Bum is available in English, Spanish, Dutch, Brazilian Portuguese, Italian, Russian, Polish, German, French, Mandarin Chinese, Japanese and Turkish.

History
Cannis and Derek uploaded their first video, Twinkle Twinkle Little Star, to YouTube on 29 August 2011. This was followed up, four months later, with their second upload, Baa Baa Black Sheep, a more complex and slightly longer video.

Little Baby Bum's popularity increased after the release of its 2nd compilation of videos which was approximately one hour long. To create a one-hour-long video they combined individual videos into long-form videos. The rationale behind this change was so that "parents wouldn't have to keep pressing the play button after each video had finished."

The OpenSlate company published a list of YouTube's 10 most profitable channels of 2014, ranking Little Baby Bum in 4th place with 270 million views and $3.46 million in earnings.

In June 2018, LBB announced an upcoming live show tour in 30 cities throughout the UK.

In September 2018, Little Baby Bum was bought by Moonbug Entertainment for an undisclosed sum. By the time of the purchase, LBB had accumulated 16 million subscribers and about 23 billion views across Netflix, Amazon, and YouTube.

In April 2020, Moonbug signed a deal with Chinese video platform Xigua Video, to host the show on its platform in China.

Rankings
Since 2014 when the video was posted, Little Baby Bum's 54-minute compilation video of Wheels On The Bus | Plus Lots More Nursery Rhymes | 54 Minutes Compilation has had 2.3 billion views and was YouTube's 39th most viewed video of all time. At that time, this video was the most-watched video of all time on YouTube, surpassing Psy's Gangnam Style, and was the first non-music video to reach 1 billion views.

As of April 2016, Wheels On The Bus had attracted over 1.33 billion views. It was officially recognized as the number one educational video by Guinness World Records in 2017.

As of 2018 Little Baby Bum was the world's tenth-largest YouTube channel with 16.5 million subscribers. In 2020 the show attracted over 1.5 billion monthly views and over 80 million subscribers.

Merchandise
LittleBabyBum signed a licensing deal to launch a set of plush toys of its main characters, extracted from the traditional English nursery rhymes, like Incy Wincy Spider and Baa Baa Black Sheep. This deal was signed with Commonwealth Toy, the same company that makes plush versions of Angry Birds, and also distributes products for Care Bears and SpongeBob.   The plush toys went on general release on 18 May 2016.

Little Baby Bum signed a toy master agreement with MGA Entertainment in August 2020 in which MGAE is the worldwide licensing agent for merchandise based on the animated show.

References

External links
Official site

YouTube channels launched in 2011
Children's mass media
Moonbug Entertainment

redpajama_set_name: RedPajamaWikipedia


text:
Geotrupes opacus, the opaque earth boring beetle, is a species of earth-boring scarab beetle in the family Geotrupidae.

References

Further reading

Geotrupidae
Articles created by Qbugbot
Beetles described in 1853


Storyteller, Various locations, Australia. . . "...A book must be the axe for the frozen sea within us..." Franz Kafka . . As you read the items in this portfolio, my aim is that you would fall headlong into each story, into a different world, and only emerge after the words have taken deep hold on your mind, extending to create goosebumps on your arms. . . Sparky.
Two tingling reviving hours that were worth impoverished decades of waiting.
Sometimes we struggle to sleep, or fight to stay awake.
Always there, part of the furniture, but now this!
My poems in a tidy convenient folder.
Generated in 0.87 seconds at 2:49am on Apr 20, 2019 via server WWW2.


I recently redesigned my blog and with that redesign, came very slow page load speeds for some reason. CB and my mom have both told me that they've had issues with slow page loading on my blog in the past, but even I started to see it with the new design. Once Ember left me a comment also noticing slow load speeds, I knew I had to get it fixed ASAP. What I discovered was actually fascinating, but maybe that's just because I'm a big nerd. Here are the changes I've made to make my blog load faster.
This is not the very first thing that I did to increase my page load speed, because I was putting it off. I knew this would be time consuming and quite frankly I was too lazy to do it. I'm listing it first for you guys though, because it is THE BEST thing you can do for your blog's page load speed. If you don't do it for old images, at least do it for all of your images going forward.
First things first, size your images down to the correct size when editing.
Although I have a tutorial on how to manually size your blog's images without using a photo editor, using this method will not help the speed at which your images load. There are some pros for that method, I personally like it because I have a Mac with retina display and it's the best way I can get my images really crisp on my screen. I've decided though, that page load speed is more important than a slightly more crisp image.
For the longest time, I've saved my images as PNGs. PNGs are awesome, but they are a much bigger file size, and that kind if quality really isn't needed on the web, only for print. Here's an example of the two below, you really can't tell much of a difference.
If you have photoshop, it is quite simple. You just save your file as a jpg, change your quality level to medium, which will decrease file size, then under Format Options, select Baseline Optimized. If you don't have photoshop, here's how you can quickly optimize your images over the internet.
1. I've been using this Online Image Optimizer website, which makes it very easy.
2. Upload the image you'd like to optimize. As an example, I'm going to optimize my images from my old post "25 Fashion Poses for Lifestyle Bloggers to Feel More Comfortable In Front of the Camera."
3. You'll see the original listed first, followed by variations of the image that have been optimized. Save the image that looks the best to you, without giving up your quality. I'm picking this one, which is a savings of 82% over my original.... 504 kb vs 89 kb. Looks just fine to me.
A speed test will not only tell you how your site's page load speed compares with others on the web, it will also give you solutions to fix it. If you have a blogger blog, I'd recommend using the Google Developer's Page Speed Insights. It'll give you solutions for both mobile and desktop versions of your blog.
2. Scroll down to the main blog post area, click edit.
3. Change the number of posts shown. I personally only show 2. Then click save.
Third Party Content is anything on your site that needs information from somewhere else in order to load. For example, I now have a Facebook like gadget on my sidebar. That decreases my page load speed, because the widget needs to go to Facebook to retrieve the information it needs to load. Third Party Content can obviously be very beneficial -- I want more likes on my Facebook page -- so just make sure it is benefitting you in some form if it's on your sidebar. If it's not, ditch it.
These are the easiest things you can go do right now to make your page load faster. If you have any other advice on increasing page load speed, I would LOVE to hear it!
This is like those 3 times in life that I've been to church. Some how you gave me exactly what I needed at exactly when I had the question floating around in my head. My page has been so ridiculously slow that I've had to block ads on my own site! That seems ridiculous to me.
I'm pretty sure my pictures are too big... Definitely going to be optimizing from now forward, because who has time to be going backwards ;) Thanks girl!!!
This is great! I need to decrease my page load time and am definitely going to try that photo optimizer that you suggested.
This is really helpful! I am guilty of using huge image sizes, too, because on my Mac, they look normal to me in Photoshop, while they are actually huge on the web. Mac is just too good for it's own good.
adore these posts. this is so so so helpful!
This is so helpful! Thanks, Sarah!
oh this is so helpful! thanks for also linking to google developers 'page speed' thing! fascinating to see and now i need to get crackin'!
This is so helpful!! I recently realized my pictures were making my blog SO slow so I've been shrinking them to load faster. I just checked my page speed and it's not amazing but it is WAY better than when I had huge images. It was at a 9/100 before haha sooo yeah! These tips are super useful because I am always trying to increase my site speed. thank you!!
This is great! I never thought of these!
first of how flattering to be mentioned by name (and link! you are sweet) it makes me feel like you truly do listen to your readers which is always a nice thing to know. Not only that though but this post is SOOO super helpful. Definitely pinning it and doing all these things when I switch my blog over to the new name.
a page loading effect with jQuery and it is also a animated page loader. You can make customization in it for better use.


will be moving out of current address and would like to request to cancel my ADSL service by 25 March 2018. Preferred communication is via email only.
I would love to help and raise this to the relevant team and request for assistance.
Kindly, PM me your account details (Username/Customer ID or Contact number associated with the account) also, include your best contact number and preferred time for a call.


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Anita Hill's Commission Launches Entertainment Industry Survey on Sexual Harassment
Dave McNary Variety November 20, 2019 11:23AM PT
The Hollywood Commission on Eliminating Sexual Harassment and Advancing Equality, led by Anita Hill, has launched a survey of the entertainment industry.
Hill accused U.S. Supreme Court Justice Clarence Thomas of sexual harassment during his Senate confirmation hearings in 1991. Since then, in addition to teaching law and policy at Brandeis University, Hill has been active in fighting against harassment and racial discrimination. She was named chair of the commission in 2017 in the wake of a multitude of sexual abuse scandals in Hollywood, sparked by revelations about Harvey Weinstein.
"Due to the heroic and brave work of many, we all now know there are serious problems of harassment, bias and mistreatment of others in Hollywood," Hill said. "What we need to get our arms around, if we're going to come up with effective solutions, is reliable data that reveals the specific nature and actual extent of those problems as well as the cultural environment that enables and hides them."
"We also want to know what is going well, and how we can improve the industry for all employees," she added. "Therefore it is important for everyone who has worked or even tried to work in the entertainment industry to partake in the survey as their experiences will tell us what we need to know."
The Ethics & Compliance Initiative will administer the survey, which is taken anonymously online via a secure website and will be available to fill out for four weeks. The commission emphasized on Wednesday that participants will remain anonymous.
"It is designed to guarantee privacy and anonymity for all participants," the commission said. "It will not be possible for responses to be traced back to individual participants, nor will any specific organizations be linked to any findings. The data compiled will enable the Hollywood Commission to develop initiatives aimed at protecting entertainment-industry workers many of whom are freelance and/or starting out in this industry and therefore lack access to adequate safeguards against workplace bias and harassment."
The survey will seek data from people who are professionally involved in any aspect of the entertainment industry, including actors, directors, producers, writers, musicians, singers, dancers, crafts people, hair and makeup artists, wardrobe and costume stylists, technicians, drivers, assistants, agents, managers, publicists and executives.
"The more varied the mix of industry employees, freelance, long term, support staff, executives, etc. who participate in the survey, the more illuminating and useful it will be," Hill said. "At the end of the day, the aim here is to help us develop as complete an understanding as possible of the issues facing the entire industry. The number of survey responses will also tell us how serious and purposeful Hollywood is at solving the systemic problems it has been so dogged at illuminating."
The results of the survey are expected to be released in early 2020. The survey is available at this website.
https://variety.com/2019/film/news/anita-hill-commission-entertainment-industry-survey-sexual-harassment-1203410532/
And we will continue to Doggedly cover this story! Woof! Woof!
*Headline photo is featured in Mr. McNary's Variety article
ATA Urges WGA To Allow Writers To Return To Agencies That Haven't Signed The Guild's New Franchise Agreement	David Simon Drops Individual Claims Against CAA In WGA's Anti-Packaging Lawsuit, Remains Part Of Broader Antitrust Suit; Writer & WGAE Issue Statements – Update


DG Set Buyer in Hydeabad A diesel generator is the combination of a diesel engine with an electrical generator (often called an alternator) to generate electric energy A diesel generator is the combination of a diesel engine with an electric generator (often an alternator) to generate electrical energy. This is a specific case of engine-generator. A diesel compression-ignition engine is usually designed to run on diesel fuel, but some types are adapted for other liquid fuels or natural gas.


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Janet Jackson on The FADER
Future, Chris Brown, and Janet Jackson added to Saudi Arabia festival Nicki Minaj pulled out of
Future, Chris Brown, 50 Cent, Tyga, and Janet Jackson will all play Saudi Arabia's Jeddah Fest on July 18. Nicki Minaj pulled out of the festival, citing concerns over human rights in the country.
Masters by Tupac, Eminem, Janet Jackson, 700+ more destroyed in UMG fire
Many of the world's most significant master recordings, including ones by Eminem and Janet, may have been lost in the devastating fire that Universal Music Group covered up a decade ago.
Janelle Monáe to induct Janet Jackson into Rock Hall of Fame
Rock Hall 2019 speakers confirmed, including Janelle Monae (for Janet Jackson), Harry Styles, Trent Renor, and David Byrne.
music / R&B
Janet Jackson announces Las Vegas residency
Janet Jackson's Las Vegas show "Metamorphosis" show will begin in May.
Janet Jackson's former tour manager sues for $300,000
Danny O'Donovan claims he wasn't paid for months of work on Janet Jackson's 2016 world tour.
Janet Jackson to be inducted into Rock Hall Of Fame
Janet Jackson is among 2019's Rock Hall Of Fame inductees alongside Radiohead, The Cure, and Stevie Nicks.
The 6 best celebrity ASMR videos of all time
From Cardi B to Ariana Grande, the best celebrity ASMR videos ranked.
culture / Internet
Janet Jackson to accept Global Icon Award at 2018 EMAs
Janet Jackson will receive the 2018 Global Icon Award at the upcoming EMAs
CBS chief executive was reportedly fixated on "ruining" Janet Jackson's career after Super Bowl
A new report details Les Moonves as vengeful following Janet Jackson's wardrobe malfunction.
Watch Normani nail the choreography for Janet Jackson's "The Pleasure Principle"
Normani paid tribute to Janet Jackson at the BMI Awards last week.
Janet Jackson shares homage to Michael's "Remember The Time" video
Janet Jackson's new "Made For Now" clip pays tribute to one of Michael Jackson's classics.
Watch Janet Jackson's tingly, insightful ASMR interview
Janet Jackson discussed her new single and favorite musicians while doing ASMR during a new interview.
Hear Janet Jackson's new song with Daddy Yankee "Made For Now"
Janet Jackson and Daddy Yankee parade through the streets of New York in their new video.
Janet Jackson is releasing a new song and video this week
Janet Jackson announced on Monday that she will be releasing a new song with Daddy Yankee on August 17.


The City Soul Choir is thrilled to present its 10th annual spring concert! This will be music director Brian Tate's final concert with the choir. People Get Ready will include often-requested CSC favourites from the past 10 years, along with some beautiful new songs. We are pleased to present a familiar face in a new role - our wonderful pianist, Michael Creber, is taking on the role of associate conductor this term, and you'll see him conducting three pieces. One is a powerful song from the civil rights movement, the 1965 Curtis Mayfield classic, People Get Ready. Today, it's troubling to see how little progress has been made in many areas of social justice. More than ever, we need to rally and fight for freedom and equality for all. It is said that Martin Luther King Jr. declared People Get Ready an anthem of the ongoing civil rights movement. Music helps drive that movement. So, people get ready, get on board, there's a train a-comin'!
Not recommended for kids under 5.