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Q: Understanding the curves of a MOSFET I am trying to understand the curves of a MOSFET. Sorry if the question is very basic.
Where the red point is is the saturation zone of the MOSFET, therefore the source drain voltage must be 0V because at this point the MOSFET is saturated conduction at maximum current, because on the X axis of the graph called Vds marks 10V for the red point.

A: Question
What do the curves and the red dot represent in the following MOSFET Id vs Vds and Vgs characteristic graph?

Answer
Part A - Meaning of the curves and the operation point

*

*The green (update: pale cyan) region is the "saturation" region.

*The yellow region is the "linear", or "ohmic", or "triode" region.

*In the saturation region, the thick horizontal (well, slightly tilting upwards) straight lines (well, OK, curves) represent the (connected) points in the region of a particular Vgs value.

*So for example, the curve that the red dot sits represents the points of Vgs = 2.5V.

*The vertical lines 0, 5, 10, 15, 20 mean the voltage across Drain and Source, Vds.

*Now the red dot operating point says this: If (a) Vds = 10V, and (b) Vgs = 2.5V, then (c) Ids = approx 16A.

Part B - Meanings of "Linear region", "Saturated region" and "Linear mode" and why the MOSFET can be "operated in linear mode at the saturated region"

(1) Meaning of "linear region"
When I first look at a curve in a two dimensional graph, I almost always look at the labels of the X and Y axis. For example, if (a) X axis is labelled "voltage across a resistor, Vr", and (b) Y axis is labelled "current through the resistor, Ir", and (c) The Ir vs Vr "curve", is a straight line starting from origin and goes, say 30 degrees, upwards, then we can conclude that Ir is proportional to Vr, or in mathematical terms, Ir is a function  Vr, ie, Ir = f(Vr), where function f, the proportional constant, is a linear function. This is the mathematical definition of a linear function.
Now let us go back to National Semi's EE engineer Locher's Ir vs Vds graph (Fig 8) and focus only at the straight line labelled "liner" in yellow, we should conclude that the straight line should represent a linear function, Ir = f(Vds), or Ir = (1/R) * Vr, where R is a constant, the resistance value in Ohms, of course obeying Ohm's Law.
We might now ask ourselves: "OK, the straight line represents a linear or "Ohmic"  function, but how come this linear "straight line" becomes a linear "region"?
Well, Prof Jaeger gives the answer with the following graph:

One thing to clarify is that the linear region shown above is a zoom in view of the left bottom corner of the big I-V characteristics.  It is only at the zoom in that we can see the linear curves separated. In the big picture, the curves are merged and becomes just one straight line.  Here, the y-axis shows current in order of 0.1mA, and voltage in 0.1V, so the resistance is approx 0.1mA / 0.1V or of the order of 1 milliOhm.
/ to continue, ...

References
(1) Microelectronic Circuit Design, 4th Ed (free eBook) - Richard C  Jaegar, Travis N Ballock, McGraw Hill 2011
(2) MOSFET Characteristic Curves (Ohmic, Triode & Saturation Region) (25 min YouTube) - Dr Sunanda Manke, Barkatullah University
India 2020sep03
(3) Linear Mode Operation and Safe Operating Diagram of Power-MOSFETs - J Schoiswohl, Infenion, App Note V1.1 2017may
(4) AN-558 Introduction to Power MOSFETs and Their Applications, Doc No SNVA008 - Ralph Locher, National Semi, 1988dec (page 5 for the description of linear and saturation regions)

Appendices
Appendix A - Recommended reading list of the Jaeger book
Part 1 Solid State Electronics and Devices
Chapters

*

*Chapter 4 Field-Effect Transistors page 145,

*Chapter 5 Bipolr Junction Transistors page 217

Sections

*

*Saturation of the I-V characteristics, Section 4.2.4, Page 154, Fig 4.8

*Mathematical Model in the Saturation (Pinch-off) Region, Section 4.2.5, Page 155, Fig 4.10

*NMOS Transistor Mathematical ModelSummary (Cutoff region, Triode region, Saturation region, Threshold voltage) Chapter 4, page 160.

Appendix B - Clarifying concepts and terms in MOSFET characteristics graph
Linear Mode Operation and Safe Operating Digram of Power-MOSFETs - J Schoiswohl, Infenion, App Note V1.1 2017may

Appendix C - Comparing and Constrasting between MOSFET and BJT
Introduction
MOSFET and BJT, by their structure and operation mode, cannot be easily compared, though can be more easily constrasted.  The following discussion is limited to NPN BJT and N-channel MOSFET, and are over simplified and therefore potentially misleading.
1.1 BJT is basically a "current device".  So we talk about (a) current amplification gain Ic/Ib and (b) current switching.
1.2 MOSFET is basically a "voltage device".  We change Vgs which causes a change in Rds and therefore Ids and Vload. So the amplification is more indirect.

Appendix D - Linear Region vs Saturation Region

/ to continue, ...

A:
therefore the source drain voltage must be 0v because at this point
the mosfet is saturated conduction at maximum current

No, you have this wrong. Maybe you were perhaps thinking of the BJT saturation region (when the collector-emitter voltage is close to 0 volts)? If so, then you'd be correct but, it's the other way round for a MOSFET - the channel is saturated rather than the base/collector on a BJT.
From Wiki on MOSFETs: -

A: If you will ever find a magic MOSFET that has a drain-source voltage drop of zero at any measurable current through the channel at any operation mode then let me know immediately. That would be a straight way to a near 100% efficient DC-DC converter circuit and to an enormous success on the power supply market. Your graph only shows how wide the channel is open at different constant gate voltages. Obviously it is the more the gate voltage the lower the channel resistance within the "saturation" region.

A:
I am trying to understand the curves of a MOSFET.

You also need to understand the (output) curves of other transistors - JFET, BJT, etc. Interestingly, however, they are very similar in that in the area of the red dot they are almost horizontal. This means that when the (drain-source or collector-emitter) voltage changes over a wide range, the (drain or collector) current hardly changes. Elements with such behavior are current-stabilizing nonlinear elements... and they are used to make the very useful constant-current sources. But how do they do this magic? The general idea behind them can be explained by the concept of "dynamic resistance".
Think of the output part of the transistor as a variable "resistor" that, in contrast to the humble "static" resistor, changes its resistance in the same direction and rate when the voltage across it varies. For example, if Vinc increases, Rinc increases, and v.v., if Vdec decreases, Rdec decreases as well. So, in Ohm's law, both the numerator and denominator increase simultaneously and the current does not change - I = Vinc/Rinc = Vdec/Rdec = const.
In this way, transistors behave as "dynamic resistors" that keep the current constant.

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Selling With Story
SEP Episode 6: Building a Niche Business
Today we are interviewing Hannah Crum. Now Hannah Crum is a case study that I think Seth Godin would just gush over. She's got an amazing business that she's built all around a unique passion of hers; brewing kombucha. She's transformed that over many years from serving a small audience, a small local group to a thriving eCommerce business. And is even building an association and scaling this up in ways that you could not believe, and I'm sure she never would've imagined possible when she started out. She's got a lot of great information and stories, on how you can organically grow your brand, create good content and build a thriving business based off it. Lots of good tips in here today and I'm excited to share them with you
[02:18] What is Kombucha
[03:11] How Hannah started her Kombucha business
[05:22] Why Hannah decided to teach others how to make Kombucha and created Kombucha Kamp
[6:31] How Hannah transitioned to online
[9:37] Hannah's traffic drivers and how she keeps her customers excited about Kombucha
[13:15] Learn how Hannah used the success of her book to drive sales
[17:59] The biggest challenge Hannah faces when working with traditional marketing teams
[19:36] Why it's important to give something away
[20:46] How Hannah takes her potential clients from reading content to purchasing products
Hannah Information
Kombucha Kamp
Free Kombucha DIY Guide
Kombucha Kamp Store
Kombucha Kamp Facebook
Hannah Crum, the Kombucha Mamma Facebook
The Big Book of Kombucha
The Artist's Way
Kombucha Brewers Organization
Transcript of Podcast
Kyle:
Today we are interviewing Hannah. Hi Hannah, welcome to The Story Engine podcast.
Hannah:
Thanks Kyle. Glad to be here.
Now I'm excited to interview you because you've been involved building up a business around kombucha which is a somewhat new or maybe not new at all, but recently reemerging home brewing DIY kinda phenomenon, and you're right on the edge of this with your business. So why don't you introduce yourself and tell us a little bit like what is kombucha?
Sure. I'm Hannah, known as the Kombucha Mamma. I've been brewing and teaching people about how to make kombucha since 2004. Kombucha is fermented tea, so just like sauerkraut is fermented cabbage, wine is fermented grapes, beer is fermented grain, salami is fermented meat, cheese is fermented milk. Right? We eat all of these fermented foods on a regular basis, sometimes we don't realize they're fermented like chocolate is fermented. But kombucha is tea and sugar, so sweet tea, to that, we add our culture. The culture has a special name, it's called a SCOBY, which stands for Symbiotic Culture Of Bacteria and Yeast. And those bacteria and yeast immediately start consuming the sugar and the tea and break it down into these healthy organic acids.
Awesome. And so take us back to 2004 when you got started in this. Did you … Were you brewing kombucha before this or was this when you started teaching and helping others do it themselves?
It was … I actually probably started a few months prior to then. I had first met kombucha while visiting a friend who lived in San Francisco. It's a pretty groovy town if you've never been there. You definitely gotta check it out and at that time of my life in 2003, I was very standard American diet, didn't really understand health or how the foods I ate impacted that. And I say that by way of meaning that it's really easy to do this at home and anyone can do it. When I first met kombucha, we didn't even have a chance to try it. It was just a friend, they had jars and they were covered and just mysterious things floating around which was the kombucha. So of course, it's one of those weird words, it stuck in my mind. I came back to LA and of course, at the Whole Foods, there were shelves and shelves of it. So I grabbed a gingerade off the shelf and cracked it in the store and my first sip … Have you had kombucha, Kyle? Do you remember your first sip of kombucha?
I'm familiar with it. It's not … It is a bit of an acquired taste in the beginning.
Right. Exactly right. Even your first sip of coffee maybe was an acquired taste, right?
Of course. Of course.
And now you can't live without it. So kombucha, a lot of people get sour face 'cause it is an acidic acid ferment like vinegar. For me though, it really reminded me of pickle juice, which I had an obsession with as a child.
Like I was sneaking it out of the fridge. My mom would yell at me, "Oh, there's too much salt in that." Maybe I was having a salt deficiency, I don't know. But it just … I love that kinda savory, yummy flavor and I think the fact that it was alive and because I wasn't eating foods that had that kind of alive quality them, it just really struck me. I felt physiologically the impact of consuming the kombucha and like everybody, my thirst dug through my budget, and because I had seen somebody making it themselves at home, I was like, "Well why can't I do that?" So I went to the library, checked out every book and started making it at home and of course, those first batches just like any time you try a new recipe, weren't necessarily all that tasty. But this is where doing the practice, engaging in the brewing process, you kind of hone your skills, you learn new things and I just really fell in love with it. And I took an Artist's Way workshop, I don't know if you're familiar with the Artist's Way.
I've read the book. Yeah.
Yeah, exactly right. So I did a workshop format of that, which was really great because by the end of it what I had uncovered is what I really wanted to do, which was to teach people about kombucha. Now that wasn't a career choice, it was just something that I felt impassioned and really wanted to get authentic information into the world. And that's when I started Kombucha Kamp as a workshop in my home where you come and learn about kombucha, see the whole process, try some of my homebrew and then, of course, I would have cultures to give to people so they could start with their own at home.
That's fascination. So you at first iteration of this business was just inviting people over to your house and maybe having tasting parties or showing them the process of growing this or-
Yeah, creating it. Fascinating. And so how did that go? How long were you just doing kind of your … the at home kombucha parties and how did you transition into an online format?
Well, it was interesting. Now we kind of take for granted all of these websites with video tutorials that teach you everything you wanna know. But back in 2007, they were just getting started and so I think I responded to an ad on Craigslist, where they wanted to find people who taught interesting things to do a video series. So there was a really great video series on … I wanna say eHow. I can't remember if that's the name it still has right now, that shows my whole Kombucha Kamp in my home and that was kind of an early genesis and then I started blogging about it because again, I was frustrated by the lack of authentic information about kombucha on the internet. And even today, you can go and read these like circular references where everyone repeats this same thing, but there's no actual original citation. And so I just wanted to put authentic information out there and then when I started the blog. So in 2007, I put it online and just started sharing that information through this new format to reach people and people started reaching back. First of course with questions and then asking, "Hey, do you have any SCOBYs? Do you have this? Do you have a that?" And so that then led to putting a couple PayPal buttons up on the blog so that people could grab a SCOBY if they needed one.
Now my husband has a film background. He worked in documentary film and production and all kinds of things like that, and he was kind of in transition considering maybe a career change into doing a video for bloggers. And so as a test case, he decided to help me out and shoot some videos of the brewing process. I needed some educational videos and things like that. And through working together, we found that we actually had a very productive partnership and then around this time in 2010, when they took all the kombucha off the shelves at Whole Foods, we kinda had a surge because all of a sudden people weren't able to access their kombucha. They were kinda freaking out and so, of course, they wanted to make it themselves, and we had already developed a couple of packages at this time. It wasn't a storefront at this point, but that kind of inspired us to get an eCommerce site off the ground and that's when my husband dove in. He learned HTML, CSS, got us onto an eCommerce platform like he really became this driving force behind everything we were doing, and that's basically the launch of our business.
Now, of course, both of us still had jobs at that time. This was kind of our side hustle. It's just organically evolved from there and I think finally in 2014, I let go of all of my other side jobs and things like that and been doing kombucha full time ever since.
That's beautiful. And so leading up to then and maybe since 2014, I would really like to know what are the main channels that you're getting to spread your message out there. You've mentioned you started with video and right now video is very, very trendy, very, very powerful, and if you've had that much of a head start, then I'm assuming that's one of your best channels. How are you driving traffic to your site? Is the blog generating a lot of traffic and yeah, what's keeping people excited right now?
Well ironically, although our start was in video, we have since founded a trade association of which I'm a part-time president in my spare time, and we've also launched a book, our Big Book of Kombucha, which an Amazon bestseller. We've sold almost a hundred thousand copies in just two and a half years.
Oh, my goodness.
Yeah. So it's a really-
That's huge.
Right. But then writing the book and all that … So ironically, we've gone away from video, but it's definitely something we need to come back to. So we do have a YouTube channel, but you probably haven't seen any new videos on there in a little while. What that means though is we have a very robust Facebook group, we another forums site and then we also have Instagram and just do a lot of social media. We write for other publications. So really, anyone who wants to know about kombucha, we're there to do podcasts to talk about. Really, I see myself as an ambassador for the culture. Right? I'm here to tell you why it means you no harm, it means you a world of good and of course through cultivating the industry. Right? By supporting the industry through the trade association, what that means is we've also created all these jobs. Right? So because kombucha has somewhat of a low barrier to entry similar to craft beer in that you can be a homebrewer, love it as a hobby and then actually turn it into a viable business. And because probiotics and microbiome and understanding that we really need to get our nutrition from what we're putting into our body, not just in the form of pills or powders and things like that, kombucha I think is at a very influential point in its development. We see it as the 21st-century yogurt. Right?
Well, you and I probably remember when yogurt was sold in the stores, but a generation before us, you had to be a crazy hippie making it at home on your countertop. Like you couldn't just go to the store and buy yogurt. Now, of course, it's multi-billion dollar industry and sold on the fact it was probiotic and helped people live to be an old age. And so kombucha I think is experiencing a similar phenomenon right now, and the reason I mention all of this is because, think about it like this. The more people who've tried kombucha from a store, the more who've even heard the word-
And then if they end up like me where their thirst outgrows their budget, at some point, then they're gonna wanna try to make it themselves. And so we've kind of fueled this whole trend of course towards people knowing about kombucha, reincorporating it into its popularity … It's had actually multiple points of popularity throughout time, but of course, there's nothing like an internet to consolidate all of that information and make it easier for people to find instead of little sheets of paper that they get passed around with a weird SCOBY in a bag.
Yeah. Tell me about … I'd love to know a little bit more about your book and how … Was there a way that you designed your book to drive attention and traffic back your site and your store, and can you tell me some of the strategy on how you leveraged the big success of your book to really … Because I think a lot of people when they think about books, it's, of course, nice to think about retiring on just book royalties alone. What I find books very useful for and how mine have worked really well is by … They're like a first step in the process. You introduce them to an idea and often I find a popular strategy these days is to give something that you can collect, their emails or give them a next step to engage with you in the book. Is that a strategy you used?
So ours is with a traditional publisher. So we were limited in how exactly we could … We were able to put 'Founders of Kombucha Kamp' on the book, which was really important. In fact, it is a way in which a lot of people now find us. Unfortunately though, sometimes will find other brands and they also have our book, but ultimately, of course, it does bring them to us. And you just have to google kombucha and you're a stone throw from any of our content. We've done a great job with SEO and really writing the book actually put us on hiatus from doing all of that, and so now we're ginning back up the content. But prior to all of that, the book really came … it came from the blog. It was turned into a 100-page pdf handbook that came with some of the kits and cultures that we had for sale, and then we were able to leverage that into the 400-page book deal. Right?
So it had its own kind of natural evolution as it went and these days, I don't know how easy it's been for you to get book deals Kyle, but it seems like they want something similar to like a record deal. They wanna see do you have a platform already, can you actually sell this, are you viable, whereas in the past it used to be, "Oh, I have this interesting idea that nobody else has had. Here, let me write a book about it." Right? These days they want demonstrable ability to sell that book before they wanna engage with you anyways. So that's … All of that has worked really well in getting the word out, but it's also because there's a low barrier to entry, because the culture's so highly reproductive, it's also led to a lot of competition from sellers on Craigslist and eBay and … As much as people understand the difference in quality for vehicles, right? Everyone knows the difference between a Lexus and a Toyota, they don't always understand the difference in quality when it comes to something that … like a kombucha culture, when in fact there is. There's always a difference in quality whenever you're considering what you're gonna put into your body.
Absolutely. So just retracing the steps of your story, what I love is like this is a … Yours is a case study that I think Seth Godin would go crazy for because you saw a problem, you saw your passion and you wanted to work in that, and then I think a lot of the questions that I get from my readers or listeners is, "What do I need to do? How can I like …" They wanna cut straight to profit or straight to having a successful Kickstarter campaign because that's all they see. They see all of a sudden this new invention on Kickstarter and blam, it's a huge raging success and I think that's a very rare case, that it's actually just kind of a spark out of nowhere. But what you've done is again like you were saying, organically you started solving a problem, creating content around it, having conversations and always focusing on serving the people that were right in front of you right away, which brought more people to you and spread the word.
And I'm sure … I wanna ask you about your SEO in a moment because I'm guessing like for the first while, you probably weren't that concerned about it. You were probably trying to just solve a problem and describe it as best as you could, and those took care of itself. And another thing that I loved that you told me is that the book that was this incredibly successful book, was originally just a small handbook that you were giving away to help your customers succeed, which again, a lot of people enter book marketing hoping to just get their … get the results that you did. You were designing something to be helpful from the ground up for the people you were already serving and I think that that's a really, really powerful story that a lot of people who are in the early stages of a business, no matter if it's in health and wellness and any kind of industry. Just learning how to start these conversations, create good content, tell a good story and share your story online and if you're tapped into the right place, then people are gonna find you.
That's exactly right. And what you're hitting on the head is helping others because … and it's a lot of hard work, like it doesn't just magically grow itself. You have to put in the work and the other side of this is we have a product based] business, and that comes with its own host of challenges. Right? You have to figure out shipping and managing inventory and all of those other aspects that go beyond just I show up and write a blog. It's very different … And more than that, we're not even selling a ready to drink product. Like you can go to a store and think, "Oh, I've never had a kombucha. Sure, I'll try it once." But to take home a culture and decide you're gonna ferment and make it at home, that I think has been the biggest challenge with working with traditional marketing teams or a traditional SEO because what works for widgets doesn't always work for a lifestyle.
And really, it's giving people the information that they need knowing that when they're fully informed on a process or they understand what it is they're going to be undertaking, that they can move forward into that with more confidence. Not everybody's gonna read everything before they dive into something. A lot of people just wanna jump in and get their hands dirty and kind of learn that way as well. So there are many ways to kind of approach that, but it's just been by like absorbing, reading, researching. That to me is fun and interesting, to kind of learn all of these details, this minutia, and then to have my husband who's this wonderful balancing force. I'm the like, "It's a miracle. It's gonna save the world.", and theoretically that could be true, but you always have to balance that kind of enthusiasm with, "Okay. But it's a food like any other and no one food is ever going to be everything you need to consume ever because that's not how human beings are designed."
And … So it's also not getting totally caught up in the drama or the excitement of the thing that you're working with, but really staying focused on how do we serve the people who need this information, because you're gonna end up answering the same questions again and again and again. But it's important that even if you're tired of doing that, you still show up with a smile and present the information to that new person because for them, you're creating a relationship, you're creating a contact point. They're like, "Oh, I can trust this person because they didn't ask anything of me, and yet they gave freely of their information." And so we've had a freemium for a long, which you probably talk about in many of your shows-
About how important that is to give something away and that's been an important part of being able to build a list. And then … Again, marketing to them is very different than to other widgets.
To that point, I'd love to hear kind of what you have set up right now about … How do you do to take them from their first point of contact, they're consuming your content, to making a purchase in the store? How do you guide them through that process? Do you have … You've got a freemium play right now. So what do you do to kind of level them up and show them the value that you can create?
Yeah. Well obviously where we're going to maximize value, not only to them but to us, is by selling our higher priced packages. Right? And again, most people aren't gonna … who just occasionally drink kombucha aren't gonna think, "Oh, let me drop $300.00 on a kit that's gonna help me make kombucha all the time." So first, you have to be someone who's really excited and into it. And so when you get our … It's an email a day for five days, so we try not to over inundate people. They also get a downloadable recipe as well as a brewing guide with that. So you have some assets that you can work with immediately and then we just kind of gradually walk them through what kombucha is, how it can help and then leading up to why it's beneficial to jump into continuous brewing, 'cause it really is. It saves time, it saves effort, ultimately it saves money, but people have to kinda come to that information themselves and our philosophy is to trust your gut. That means don't do something because I do it. It means listen to your body. When you're getting feedback, does this resonate? Does this feel good?
And so it's a very different sales technique than, "You must have this now!" Or "Limited time! It's all running out!" It's a very different approach because it's very gradual and it's about helping people come to this decision themselves. And so the way we do that is with just really quality information that allows them … Maybe continuous brew isn't for them right now, they're gonna start with a smaller kit or a smaller package, and then ultimately they know they can come back and get the pieces they need from us. And the other point of specific differentiation, is we try to invent products that fit our niche.
So we've developed a heater with a thermostat at a time when there were no heaters with thermostats for brewing and fermentation. There were kind of brew belts and things you had to monitor on your own, but we came out with one that has a thermostat. Now, of course, you can find a lot of these in a lot of places, but we also developed a vessel that has a unique shape and we work with a potter. It's made in the U.S.A., so we continue to try to create these points of differentiation that other people who just wanna sell some SCOBYs or whatever aren't thinking of in terms of catering to the entire experience.
[bctt tweet="Create points of differentiation in your content and think in terms of catering to the entire experience. -Hannah Crum" username="kylethegray"]
I think that's beautiful. I think that's really exciting and being able to package a bunch of different products into one big kit to show a lot of value, I think is really powerful and essential for an eCommerce plan. I love what you were touching on where there's much information in the digital marketing world, especially where I live in all the time, which is all this kind of high now urgency, kind of fear-driven copywriting. And that's one of the reasons why I love content and building relationships and aiming for something longer than just a quick sale, which I think you've done so well and which is why I was so happy to have your story here today. Hannah, you've mentioned a lot of your different products, but where can we go to learn a little bit more about you if people are excited about kombucha and ready to start their own homebrew or just wanna learn a little bit more about you?
Absolutely. So kombuchakamp.com, that's Kamp with a K 'cause I'm a word nerd. I'm [kute and klever]. Yes, those all had Ks. But Kombucha Kamp is the best first place to go to, from there you can also go to our store. We do four cultures in total. So we do kombucha, which is the fermented tea. We do jun or jun, which is its green tea raw honey cousin. And then we also do milk kefir and water kefir and all of these are in a living form and we have loads of content for all of them. So if you're into fermentation at all when it comes to fermented drinks, come check us out because we have that information there.
And then, if you're someone who wants to start your own kombucha business, we do offer consultation, but then there are also great resources at the trade association, which is kombuchabrewers.org. So you can also find me there. We have a lobbying effort. Our trade association has really grown quite a bit. So we started with 40 member brands and we're over 300. So it's just a testament to how quickly this industry is growing and how much our efforts are contributing to that process. And of course, people are seeing that there's an opportunity and we wanna make it easy for them to take advantage of that because right now, there's no one producer that can make enough kombucha to satisfy the world's thirst. So it's really … If you're considering getting into a business and you're afraid of hard work, fermentation whether it's drinks or sauerkraut or whatever, everybody needs it. Everyone's sick and they need a good, local option. So highly recommend that if you're not afraid of hard work.
Amazing, Hannah. Thank you so much for joining us.
Thanks, Kyle. Really great to be here.
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SEP Episode #177: The Value of Surrounding Yourself with Experts with Reed Davis
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SEP Episode #175: 2021 Year in Review for Kyle and The Story Engine
SEP Episode #174: Misadventures in Kyle's Musical Past
SEP Episode #173: Your Faulty Sense of Risk and Reward
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Firefighters put out brush fire close to Halfmoon Bay home
Fast moving flames were reported on Wednesday, July 27, and firefighters quickly extinguished the fire that 'had the potential to get out of control very quickly.'
Keili Bartlett
1 / 1 The Halfmoon Bay Volunteer Fire Department quickly responded to a brush fire near a property on Leaning Tree Road on July 27. Halfmoon Bay Volunteer Fire Department
As a brush fire on a private property quickly began to spread, the Halfmoon Bay Volunteer Fire Department rushed to the scene from the fire hall, where three members were already gathered.
Homeowners reported a fire on their property on Leaning Tree Road in the afternoon of July 27. When the firefighters arrived, the fire was only 40 feet away from the home. It spanned 3,000 square feet and was starting to climb trees, a July 29 press release from the Sunshine Coast Regional District (SCRD) said.
A total of 17 members responded to the call for help, fire chief Ryan Daley told Coast Reporter. He, the deputy chief and a volunteer firefighter left from the fire hall, while the assistant chief was able to drive the duty vehicle from his house. "There were a few of us on scene really quick," Daley said.
When they arrived, Daley said he grabbed the pre-connect hose and immediately began to suppress the fire. Once the flames were extinguished, the crew stayed on scene through the evening to monitor the area.
The cause of the fire is still under investigation. The call came on Wednesday, about midway through a heatwave covering much of the province.
"The ground is getting dry, the heat's not helping, the relative humidity is not helping. So, the conditions are getting very good for brush fires," Daley said.
"This is a big reminder of how important it is to FireSmart your home," Daley said in the SCRD's press release. "The techniques used by FireSmart assist in slowing the spread of fires and help to protect your home. In this instance, it's fortunate that the fire department was in a position to provide such a quick response, with a number of resources as this fire had the potential to get out of control very quickly."
The SCRD's press release also issued a reminder — ahead of the B.C. Day long weekend — to practice safety and awareness around preventing wildfires.
"A fire needs an ignition source to start. So, we have to be extremely careful with anything we're doing that has an ignition source," Daley said. That could be anything from cigarettes to barbeques and camping stoves.
Off-duty firefighter prevents 'torched' truck fire from spreading
Two hectare wildfire north of Egmont declared out
Marina fire torches four boats in Garden Bay


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Q: Parsing Part of a file that is fixed width I've got a file that is fixed width in the first half and table delimited by "," in the second half. When I copy part of the file and save as another file, the python function pandas.read_fwf(file_path) works perfectly as read_fwf can infer column lengths.
However, when I try to use read_fwf(file_path, skiprows = 2, nrows = 75) to read only the fixed width part of the input file, it does not correctly infer the columns, and simply returns a DataFrame with 1 column.
Are there any workarounds or solutions


text:
MAINE & NEW HAMPSHIRE
Email: nwalsh@gwi.net
Jones Act
The Right to Wharf Out
If your land abuts navigable waters, whether fresh or tidal, your property ends at the water's edge. The state owns the submerged lands. At common law – that's the law judges make when ruling in court cases, as opposed to the statutes made by Congress or state legislatures – the owner has the right to make reasonable use of the abutting stream, including the right to build a warehouse by the water's edge, and to build a wharf extending into the water to the edge of the channel. This is the right to "wharf out", and it still exists – after a fashion.
The right to wharf out has always been subject to the public's right to use the channel: a shorefront owner never could build a wharf that blocked the channel. Now the right to build a wharf is subject to local, state and federal approvals. Of these, state approval is likely to the biggest challenge.
State approval is controlled by Maine's Natural Resources Protection Act. This extensive law controls development in the parts of Maine most sensitive to development, including fresh and salt water shorelands. NRPA requires that any proposed construction or activity submitted to the DEP for a permit "[must] not unreasonably interfere with existing scenic, aesthetic, recreational or navigational uses." The decision whether to issue the permit lies with Maine Department of Environmental Protection, Division of Land Resource Regulation. Its charge is to see that a project avoids and minimizes damage to the marine environment to the greatest extent possible.
Whether the permit will issue turns on three sets of factors. The first set asks, in effect, whether the damage which even a carefully executed wharf will cause can be avoided – by avoiding building the wharf at all. DEP wants to know how badly you need the wharf. Are you a commercial fisherman? Is there a marina nearby? What about a boat launch? Have you asked about availability?
Second, what kind of physical impact will your project have? Will the pier be built on pilings, granite cribwork or – most difficult to permit – solid fill? What sort of habitat will the project be built on? DEP requires the applicant to sample the habitat, determine what sorts of worms, clams etc. occupy the project site, and their relative abundance. What will the project's impact be on the non-tidal marine environment? Will the wharf affect shoreland bird or wading bird habitat, an issue of increasing concern to DEP lately? As a practical matter, the landowner will probably hire a biologist.
The third set of factors is often the most tricky: Characterizing how the completed project will affect existing uses. Some of these uses are aesthetic.. Will the project be visible from a "National Natural Landmark or other outstanding natural feature"? What about a state or national wildlife refuge, sanctuary, or preserve, or a state game refuge? A state or federal trail? A public site or structure listed on the National Register of Historic Places, a national, state or municipal park, a public open space, or "a publicly owned land visited, in part, for the use, observation, enjoyment and appreciation of natural or man-made visual qualities"? If it is visible, is it visible year 'round, or does foliage screen it in summer? These are tricky considerations.
Other uses are navigational, and DEP (as well as the Army Corps of Engineers) want impact on navigation minimized. Wharf applications have been denied because the wharf would interfere with the ability of sailboats boats to race around a cove or small bay, recreation being a recreational "existing use."
Complicating matters for the would-be wharf owner is that most applications require public notice and a public comment period, and sometimes hearings. Until a few years ago DEP allowed wharfing out applications to proceed by "permit by rule". Under permit by rule, widely used by agencies, the agency determines that projects which meet certain minimum criteria may be permitted without individual application. But wharf applications are too individual, and too varied, for permit by rule, and after too many trips to court (by denied applicants as well as by aggrieved abutters), DEP dropped permit by rule for wharfs.
Covid and the Jones Act January 15, 2023
Homeowner's insurance policies and marine claims January 8, 2023
A Bad Way to Lose a Case December 16, 2022
The Jones Act Plaintiff November 29, 2022
Strange Facts, Great Case October 26, 2022
Keeping the Port in Portland October 23, 2022
For Want of a Nail September 21, 2022
Recreational Boating Injuries August 22, 2022
Covid and the Mariner September 27, 2021
North Pacific Voyage August 30, 2021
The Q Flag April 9, 2020
Bread and Water March 4, 2020
Property in Divorce January 13, 2020
Where Was I? October 4, 2019
Saving Taxes on Boat Purchases May 2, 2018
Crew Agreements? Yes, crew agreements. November 8, 2017
Duty July 7, 2017
Behind the Veil June 14, 2017
Home Grown Estate Planning May 10, 2017
Boilerplate March 26, 2017
© 2020 Law office of Nicholas H. Walsh, P.A.
WordPress Development by Maine Hosting Solutions


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Artists are the vanguard of the urban revolution
A 5 minute read by Tom Bloxham
Artists are the vanguard of the urban revolution and Urban Splash has had a proud history of supporting them in various ways.
When you look at London, part of what's made it a great international city is it's diversity, and the way artists have flocked there, enriching its cultural life by setting up studios, boosting exhibitions and pop-ups - and asking the difficult questions.
It makes me sad that they are increasingly being priced out not only of London now, but of other cities too; the financial success of London and subsequent increase in property prices is possibly killing the very thing that made it such a desirable city.
Paradise works in Salford
Elsewhere, in cities across the UK, Urban Splash is trying to help support the arts ecology; in Manchester we have supported Paradise Works - which is located on East Philips Street, Salford adjacent to our development at Irwell Riverside. Developed in response to a crisis in studio provision, the ambition of the artists behind the new Paradise Works studio was to create a sustainable urban model for artist-led activity in and around Manchester. That became a reality thanks to our support along with the Arts Council England - the result is a studio which is now home to more than 30 artists.
Ocean Studios at Royal William Yard in Plymouth
In Plymouth, we have achieved similar arts results. We were the catalyst setting up Ocean Studios, helping a not for profit raise funds from myriad of sources, supported by Urban Splash, Plymouth City Council, ERDF and others. The space is now being run by RIO (The Real Ideas Organisation) it gives artists a base.
S1 Artspace at Park Hill in Sheffield
At Park Hill in Sheffield too, we have been long-term supporters of S1 Artspace and are currently assisting them with a big capital fundraise to help them create a new and permanent centre at the scheme.
The place for arts within our development is one big factor, but another is the broader commitment of our Urban Splash directors who each have many personal affiliations with arts organisations; I've had the privilege of serving on the Arts Council and the Tate - and am Chair of the Manchester International Festival. Many of my colleagues do likewise.
Here are some of the other arts projects we have helped support over the past 25 years, you can find out more about our extensive work in the arts here.
Kid Acne installation at Park Hill
Kid Acne installation, Park Hill 2009
Art has been intrinsic to our Park Hill development in Sheffield since day one; as well as our more recent work with S1 one of the first installations at the scheme was in 2009 when graffiti-artist Kid Acne installed artworks around our site; soon follow by Gary Hindley, who created huge canvases of original residents of Park Hill in the concrete frame windows of the building.
British Modern at Park Hill (Susan Tebby, Permutation on 7, (1973). Arts Council Collection, Southbank Centre, London, © the artist.)
'British Modern Remade', Park Hill 2011
Park Hill played the starring role here, as a piece of mid-century modern sculpture at the heart of this exhibition which was curated by Helen Kaplinksy as part of Select.ac - the Arts Council Collection's curatorial competition for postgraduate students.
Superlambanana at Matchworks in Liverpool
Superlambanana Parade, Matchworks 2008
The Matchworks was the place in which the original Superlambanana was created, so for this Capital of Culture Parade in 2008, it was fitting to bring one of the sculptures home. Our commission was a wire frame - an intended "skeleton" of a Superlambana which remains installed at our Matchworks development a decade on.
Cow Parade at Timber Wharf in Manchester
Cow Parade, Timber Wharf, 2004
The same organisers of the Superlambanana Parade also staged a similar sculpture event in Manchester a few years earlier; many of the painted cows we commissioned remain at Timber Wharf today.
Birdman installation at Rotunda in Birmingham
Birdman, Rotunda, 2005
Belgian performance artist Benjamin Verdonck lived in a nest which was suspended on the side of our Rotunda building in Birmingham in 2005 as part of the city's Fierce festival.
If you're an artist, performer; an inspiring creative with brilliant ideas, get in touch to see if we can make any of our spaces around the country work for you.
Chairman and Co-Founder
The least qualified board member, Tom sold fire extinguishers door to door, studied a degree in politics, sold records then posters and ran a market stall down Affleck's Arcade.
He made more money sub-letting the space than selling his posters. That's how it started. Following setting up a pub business, nightclub and radio station, Tom, along with Jonathan Falkingham MBE, founded Urban Splash in 1993.
More articles by Tom View full profile
Urban Splash Newsplash
Want to be kept in the loop about all things Urban Splash? Then signup for Newsplash!
Our monthly news round-up with the latest and freshest news on property development, place-making, housing, architecture, events and careers sent straight to your inbox.
Pushers and Junkies - Urban Splash and the Arts
"It's not a moment to say "It Will Never Work", it's time to think big." Our exhibition comes to Manchester


Have you made Barley Mushroom Casserole?
1. Saute onion in 6 tablespoons butter.
2. Add barley and brown lightly. Pour in casserole with 1 1/2 cups chicken broth.
3. Bake 350 deg. F. for 30 minutes. Add the mushrooms which have been sauteed in the remaining butter and the rest of the chicken broth.
4. Top with almonds and continue baking until the liquid is absorbed, approximately 45 to 60 minutes. Cook uncovered all the time.
This recipe contains potential food allergens and will effect people with Tree Nuts, Butter, Mushroom, MSG, Poultry, Almonds, Malt, Onion allergies.


The AustralAsian Academy of Anti-Ageing Medicine (A5M) is hosting their 10th Annual Conference and Expo in Melbourne, presenting an unrivalled line up of international and national experts in the field of preventative, integrative and anti-ageing medicine.
Azelis Pharma in Australia provides outstanding service to compounding pharmacies. Come along and meet the team to find out more.


text:
Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget's Disease of Bone
Xiaohui Tao, Li Liu, Xingguang Yang, Zhe Wei, Zhongzhong Chen, Ge Zhang*, Zhenlin Zhang*, Hua Yue*
Institute for Advancing Translational Medicine in Bone and Joint Diseases
Objective: To evaluate the clinical features of sporadic Paget's disease of bone (PDB) in China and further explore the underlying genetic abnormalities of the disease.
Methods: Clinical characteristics, biochemical indices, bone turnover markers and radiographic examinations of the patients were collected. Genomic DNA was extracted from peripheral blood and whole-exome sequencing was carried out to identify the potential pathogenic genes. The pathogenicity of the variants was thereafter investigated by bioinformatics analysis.
Results: A total of 50 patients (57.20 ± 15.52 years, male/female: 1.63: 1) with PDB were included and the mean onset age was 48.34 years (48.34 ± 17.24 years). 94.0% of the patients exhibited symptomatic patterns described as bone pain (86.0%), elevated skin temperature at the lesion site (26.0%), bone deformity (22.0%) and local swelling (18.0%). The most frequently involved lesion sites were pelvis (52.0%), femur (42.0%), tibia (28.0%), skull (28.0%) and spine (18.0%), respectively. Additionally, 40.0% of them accompanied with osteoarthritis, 14.0% with pathological fractures, and the misdiagnosis rate of PDB was as high as 36.0%. Serum level of alkaline phosphatase was significantly increased, with the mean value of 284.00 U/L (quartiles, 177.00-595.00 U/L). Two heterozygous missense mutations of SQSTM1 gene (c.1211T>C, M404T) and one novel heterozygous missense mutation in HNRNPA2B1 gene (c.989C>T, p. P330L) were identified in our study. Moreover, several potential disease-causing genes were detected and markedly enriched in the pathways of neurodegeneration (including WNT16, RYR3 and RYR1 genes) and amyotrophic lateral sclerosis (ALS, including NUP205, CAPN2, and NUP214 genes).
Conclusion: In contrast to Western patients, Chinese patients have an earlier onset age, more severe symptoms, and lower frequency of SQSTM1 gene mutation (4.0%). Moreover, a novel heterozygous missense mutation in HNRNPA2B1 gene was identified in one male patient with isolated bone phenotype. As for other genetic factors, it was indicated that WNT16, RYR3, RYR1, NUP205, CAPN2 and NUP214 genes may be potential pathogenic genes, pathways of neurodegeneration and ALS may play a vital role in the pathogenesis of PDB.
Frontiers in Endocrinology
https://doi.org/10.3389/fendo.2022.850462
disease-causing gene
SQSTM1
whole-exome sequencing (WES)
10.3389/fendo.2022.850462
Dive into the research topics of 'Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget's Disease of Bone'. Together they form a unique fingerprint.
Osteitis Deformans Medicine & Life Sciences 100%
Genes Medicine & Life Sciences 28%
Missense Mutation Medicine & Life Sciences 24%
Ryanodine Receptor Calcium Release Channel Medicine & Life Sciences 19%
Age of Onset Medicine & Life Sciences 14%
Bone and Bones Medicine & Life Sciences 13%
Spontaneous Fractures Medicine & Life Sciences 9%
Skin Temperature Medicine & Life Sciences 9%
Tao, X., Liu, L., Yang, X., Wei, Z., Chen, Z., Zhang, G., Zhang, Z., & Yue, H. (2022). Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget's Disease of Bone. Frontiers in Endocrinology, 13, [850462]. https://doi.org/10.3389/fendo.2022.850462
Tao, Xiaohui ; Liu, Li ; Yang, Xingguang et al. / Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget's Disease of Bone. In: Frontiers in Endocrinology. 2022 ; Vol. 13.
@article{f24d9d06aff0493f8138bc685478d46f,
title = "Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget{\textquoteright}s Disease of Bone",
abstract = "Objective: To evaluate the clinical features of sporadic Paget{\textquoteright}s disease of bone (PDB) in China and further explore the underlying genetic abnormalities of the disease. Methods: Clinical characteristics, biochemical indices, bone turnover markers and radiographic examinations of the patients were collected. Genomic DNA was extracted from peripheral blood and whole-exome sequencing was carried out to identify the potential pathogenic genes. The pathogenicity of the variants was thereafter investigated by bioinformatics analysis. Results: A total of 50 patients (57.20 ± 15.52 years, male/female: 1.63: 1) with PDB were included and the mean onset age was 48.34 years (48.34 ± 17.24 years). 94.0% of the patients exhibited symptomatic patterns described as bone pain (86.0%), elevated skin temperature at the lesion site (26.0%), bone deformity (22.0%) and local swelling (18.0%). The most frequently involved lesion sites were pelvis (52.0%), femur (42.0%), tibia (28.0%), skull (28.0%) and spine (18.0%), respectively. Additionally, 40.0% of them accompanied with osteoarthritis, 14.0% with pathological fractures, and the misdiagnosis rate of PDB was as high as 36.0%. Serum level of alkaline phosphatase was significantly increased, with the mean value of 284.00 U/L (quartiles, 177.00-595.00 U/L). Two heterozygous missense mutations of SQSTM1 gene (c.1211T>C, M404T) and one novel heterozygous missense mutation in HNRNPA2B1 gene (c.989C>T, p. P330L) were identified in our study. Moreover, several potential disease-causing genes were detected and markedly enriched in the pathways of neurodegeneration (including WNT16, RYR3 and RYR1 genes) and amyotrophic lateral sclerosis (ALS, including NUP205, CAPN2, and NUP214 genes). Conclusion: In contrast to Western patients, Chinese patients have an earlier onset age, more severe symptoms, and lower frequency of SQSTM1 gene mutation (4.0%). Moreover, a novel heterozygous missense mutation in HNRNPA2B1 gene was identified in one male patient with isolated bone phenotype. As for other genetic factors, it was indicated that WNT16, RYR3, RYR1, NUP205, CAPN2 and NUP214 genes may be potential pathogenic genes, pathways of neurodegeneration and ALS may play a vital role in the pathogenesis of PDB.",
keywords = "clinical characteristics, disease-causing gene, Paget{\textquoteright}s disease of bone, SQSTM1, whole-exome sequencing (WES)",
author = "Xiaohui Tao and Li Liu and Xingguang Yang and Zhe Wei and Zhongzhong Chen and Ge Zhang and Zhenlin Zhang and Hua Yue",
note = "Funding Information: This work was supported by the National Key R&D Program of China (No. 2018YFA0800801), National Natural Science Foundation of China (NSFC) (No. 81770874 and 81974126); the Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center (No. SHDC12018120) and Shanghai Key Clinical Center for Metabolic Disease, Shanghai Health Commission Grant (No. 2017ZZ01013). Publisher Copyright: Copyright {\textcopyright} 2022 Tao, Liu, Yang, Wei, Chen, Zhang, Zhang and Yue.",
doi = "10.3389/fendo.2022.850462",
journal = "Frontiers in Endocrinology",
Tao, X, Liu, L, Yang, X, Wei, Z, Chen, Z, Zhang, G, Zhang, Z & Yue, H 2022, 'Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget's Disease of Bone', Frontiers in Endocrinology, vol. 13, 850462. https://doi.org/10.3389/fendo.2022.850462
Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget's Disease of Bone. / Tao, Xiaohui; Liu, Li; Yang, Xingguang et al.
In: Frontiers in Endocrinology, Vol. 13, 850462, 09.03.2022.
T1 - Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget's Disease of Bone
AU - Tao, Xiaohui
AU - Liu, Li
AU - Yang, Xingguang
AU - Wei, Zhe
AU - Chen, Zhongzhong
AU - Zhang, Ge
AU - Zhang, Zhenlin
AU - Yue, Hua
N1 - Funding Information: This work was supported by the National Key R&D Program of China (No. 2018YFA0800801), National Natural Science Foundation of China (NSFC) (No. 81770874 and 81974126); the Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center (No. SHDC12018120) and Shanghai Key Clinical Center for Metabolic Disease, Shanghai Health Commission Grant (No. 2017ZZ01013). Publisher Copyright: Copyright © 2022 Tao, Liu, Yang, Wei, Chen, Zhang, Zhang and Yue.
N2 - Objective: To evaluate the clinical features of sporadic Paget's disease of bone (PDB) in China and further explore the underlying genetic abnormalities of the disease. Methods: Clinical characteristics, biochemical indices, bone turnover markers and radiographic examinations of the patients were collected. Genomic DNA was extracted from peripheral blood and whole-exome sequencing was carried out to identify the potential pathogenic genes. The pathogenicity of the variants was thereafter investigated by bioinformatics analysis. Results: A total of 50 patients (57.20 ± 15.52 years, male/female: 1.63: 1) with PDB were included and the mean onset age was 48.34 years (48.34 ± 17.24 years). 94.0% of the patients exhibited symptomatic patterns described as bone pain (86.0%), elevated skin temperature at the lesion site (26.0%), bone deformity (22.0%) and local swelling (18.0%). The most frequently involved lesion sites were pelvis (52.0%), femur (42.0%), tibia (28.0%), skull (28.0%) and spine (18.0%), respectively. Additionally, 40.0% of them accompanied with osteoarthritis, 14.0% with pathological fractures, and the misdiagnosis rate of PDB was as high as 36.0%. Serum level of alkaline phosphatase was significantly increased, with the mean value of 284.00 U/L (quartiles, 177.00-595.00 U/L). Two heterozygous missense mutations of SQSTM1 gene (c.1211T>C, M404T) and one novel heterozygous missense mutation in HNRNPA2B1 gene (c.989C>T, p. P330L) were identified in our study. Moreover, several potential disease-causing genes were detected and markedly enriched in the pathways of neurodegeneration (including WNT16, RYR3 and RYR1 genes) and amyotrophic lateral sclerosis (ALS, including NUP205, CAPN2, and NUP214 genes). Conclusion: In contrast to Western patients, Chinese patients have an earlier onset age, more severe symptoms, and lower frequency of SQSTM1 gene mutation (4.0%). Moreover, a novel heterozygous missense mutation in HNRNPA2B1 gene was identified in one male patient with isolated bone phenotype. As for other genetic factors, it was indicated that WNT16, RYR3, RYR1, NUP205, CAPN2 and NUP214 genes may be potential pathogenic genes, pathways of neurodegeneration and ALS may play a vital role in the pathogenesis of PDB.
AB - Objective: To evaluate the clinical features of sporadic Paget's disease of bone (PDB) in China and further explore the underlying genetic abnormalities of the disease. Methods: Clinical characteristics, biochemical indices, bone turnover markers and radiographic examinations of the patients were collected. Genomic DNA was extracted from peripheral blood and whole-exome sequencing was carried out to identify the potential pathogenic genes. The pathogenicity of the variants was thereafter investigated by bioinformatics analysis. Results: A total of 50 patients (57.20 ± 15.52 years, male/female: 1.63: 1) with PDB were included and the mean onset age was 48.34 years (48.34 ± 17.24 years). 94.0% of the patients exhibited symptomatic patterns described as bone pain (86.0%), elevated skin temperature at the lesion site (26.0%), bone deformity (22.0%) and local swelling (18.0%). The most frequently involved lesion sites were pelvis (52.0%), femur (42.0%), tibia (28.0%), skull (28.0%) and spine (18.0%), respectively. Additionally, 40.0% of them accompanied with osteoarthritis, 14.0% with pathological fractures, and the misdiagnosis rate of PDB was as high as 36.0%. Serum level of alkaline phosphatase was significantly increased, with the mean value of 284.00 U/L (quartiles, 177.00-595.00 U/L). Two heterozygous missense mutations of SQSTM1 gene (c.1211T>C, M404T) and one novel heterozygous missense mutation in HNRNPA2B1 gene (c.989C>T, p. P330L) were identified in our study. Moreover, several potential disease-causing genes were detected and markedly enriched in the pathways of neurodegeneration (including WNT16, RYR3 and RYR1 genes) and amyotrophic lateral sclerosis (ALS, including NUP205, CAPN2, and NUP214 genes). Conclusion: In contrast to Western patients, Chinese patients have an earlier onset age, more severe symptoms, and lower frequency of SQSTM1 gene mutation (4.0%). Moreover, a novel heterozygous missense mutation in HNRNPA2B1 gene was identified in one male patient with isolated bone phenotype. As for other genetic factors, it was indicated that WNT16, RYR3, RYR1, NUP205, CAPN2 and NUP214 genes may be potential pathogenic genes, pathways of neurodegeneration and ALS may play a vital role in the pathogenesis of PDB.
KW - clinical characteristics
KW - disease-causing gene
KW - Paget's disease of bone
KW - SQSTM1
KW - whole-exome sequencing (WES)
U2 - 10.3389/fendo.2022.850462
DO - 10.3389/fendo.2022.850462
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
Tao X, Liu L, Yang X, Wei Z, Chen Z, Zhang G et al. Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget's Disease of Bone. Frontiers in Endocrinology. 2022 Mar 9;13. 850462. https://doi.org/10.3389/fendo.2022.850462


Dr. John Flucke is in private practice in Lee's Summit, Missouri where he spends four days per week in direct patient care. He also serves as Technology Editor for Dental Products Report magazine as well as Chief Dental Editor where he writes, edits, and does video demos of products featured in his "Technology Evangelist' columns.
Doctor Flucke has one of the most popular dental blogs on the Internet "Ramblings of Dentistry's Technology Evangelist" featuring daily updates on technology in healthcare and technology in general.
He lectures extensively on all aspects of clinical dentistry as well as technology in dentistry and has been featured at every major dental meeting in the U.S. and international locations as well.
Dr. Flucke uses technology in every aspect of his practice and and personal life; pushing himself to constantly be on the leading edge. He loves testing, and breaking, the latest gear he can get his hands on. He lives his life by the motto "you can't have too many toys".
He consults with manufacturers helping with development of techniques, technologies, and products which allows him to see things from the "duct tape and zip tie stage" all the way through to the completed item.
He is a past president of the Greater Kansas City Dental Society as well as serving as the Missouri State Peer Review Chairman.
Dr. Chris Salierno is a general dentist from Long Island, New York.
He graduated from Stony Brook School of Dental Medicine in 2005.
Dr. Salierno has served as the National President of the American Student Dental Association, Chair of the ADA New Dentist Committee, and as President of his local dental society.
He lectures internationally on clinical dentistry, practice management, and leadership development. His material can be viewed on his blog, The Curious Dentist.
In 2014, Dr. Salierno became the Chief Editor of Dental Economics. In 2017, he became a Chief Development Officer with the Cellerant Consulting Group.
Our conversion rate has increased from 7% at the start to now just under 36%.
As a practice we have generated over $1.2 MM in new patient revenue each year consistently over the last several years and are on our way to doubling this number with the help of this software.
It's hard to find the time to create a dynamic social media presence and regularly develop content. Social media channels can be a powerful source of new patients and a platform for educating existing ones about our services, so the effort is worth it! Fortunately MMG Fusion helps our teams create and schedule content efficiently. We can even track practice revenue from these initiatives so we can intelligently refine our marketing. Whether you're a social media novice or expert, MMG Fusion has the tools you need to get results.


text:
Statement: CMPA welcomes BTLR What We Heard Report
OTTAWA, June 26, 2019—The Canadian Media Producers Association today issued the following statement on behalf of its President and CEO, Reynolds Mastin:
On behalf of our more than 400 members across Canada, the CMPA welcomes today's interim report from the Broadcasting and Telecommunications Legislative Review Panel, and thanks its Chair, Janet Yale, along with her fellow panelists for their considerable efforts in consulting widely with industry stakeholders and Canadians across the country.
Canada's independent producers share the government's goal of a strong, vibrant sector that will continue to produce compelling Canadian stories for the screen for both domestic and international audiences. Key to meeting this objective, in an increasingly global media ecosystem, is a legislative foundation that allows Canadian producers to own and control the intellectual property they develop and create.
We look forward to the Panel's final recommendations to government in early 2020.


Come learn about the great volunteer opportunities available at Career Wardrobe and The Wardrobe Boutique!
In order for us to prepare the correct amount of volunteer packets, an RSVP is requested. RSVP in the Tickets link below. Thank you!


Five companies, including one founded by two UB medical researchers, have been approved for START-UP NY through their affiliation with the university.
The companies, which will start up, expand or relocate on or near UB's campuses, expect to create 39 jobs and invest $597,000 in the region within five years.
Each company has ties to the university's academic and research strengths, will collaborate with UB faculty researchers and offer internships, scholarships or jobs to students.
START-UP NY stands for SUNY Tax-free Areas to Revitalize and Transform Upstate New York. The program aims to spur economic development by enabling universities to identify areas where new and expanding businesses can operate for 10 years without paying New York State business, corporate, income, sales or property taxes, or franchise fees.
Since Cuomo announced the program, 42 companies — including these five — have pledged to move or expand in the Buffalo Niagara region and work with UB to further their respective businesses. The 42 companies plan to create 1,491 jobs and invest $47,241,322 in the region.
CytoCybernetics, a startup company founded by UB researchers Glenna Bett, associate professor in the Department of Obstetrics and Gynecology, and Randall L. Rasmusson, professor in the Department of Physiology and Biophysics. The company, which is developing technology to increase the safety of all drugs prescribed to humans, expects to create four jobs and invest $41,000.
It will move into the Sherman Annex on the South Campus. The company plans to work with UB researchers and the Office of Science, Technology Transfer and Economic Outreach (STOR). It also intends to create internships and hire graduates from the engineering, medicine, management and law programs.
Geocove, an existing software company from Florida that builds geographic information system (GIS) products that government agencies can use to assess damage. Founded by UB alumnus Karyn Tareen, the company expects to create five jobs and invest $60,000.
It will move into STOR's business incubator at Baird Research Park adjacent to the North Campus. It plans to work with UB researchers and recruit interns and graduates with GIS expertise from UB's geography department.
Natural Energy Systems Inc., an existing company from Canada that is developing proprietary technology to convert organic materials, without incineration, to gases that can be used to create electricity or biofuels. The company expects to create five jobs and invest $50,000.
It will move into STOR's incubator at Baird Research Park. It intends to work with researchers from the School of Engineering and Applied Sciences and the Center for Industrial Effectiveness, more commonly known as UB TCIE, as well as recruit interns and graduates from UB.
Patient Pattern (Greenwich Geriatrics), a startup company that is developing software to assess care needs and identify risk for geriatric patients and health care organizations. The company expects to create 20 jobs and invest $355,000.
It will move into UB's New York State Center of Excellence in Bioinformatics and Life Sciences (CBLS) in downtown Buffalo. It plans to work with researchers from the School of Medicine and Biomedical Sciences and UB's Center for Computational Research (CCR), and expects to recruit interns and UB graduates.
Zintera Corp., a California technology company that develops software models inspired by the brain to explore big data and small data sets for health care, genomics and life sciences commercial applications. The company, whose headquarters will remain in California, expects to create five jobs and invest $91,000.
It will open an office in CBLS and plans to work with researchers from UB's Institute of Healthcare Informatics and CCR. The company will recruit PhD graduates from the schools of medicine and engineering.


If Curves Could Talk: Nails of the week: OPI Nicki Minaj "Save Me"
Nails of the week: OPI Nicki Minaj "Save Me"
This week I am trying out Nicki Minaj's "Save me" from her OPII LINE! I had seen some wear it alone, but I got a NEW nail polish from my friend Mari, that I just HAD TO pair the two up. However MAINLY focusing on the OPI "Save me".
Base: Wet N' Wild "Buffy the violet slayer"
Top: OPI Nicki Minaj "Save me"
I really did fall in love with her OPI line and this glitter. As you can see it has shreds of glitter, which in the Muppets Collection was dots of glitter. It also has a rainbow effect to it, which totally made my nails POP!
Have you tried any of her line yet?
What color are you nails this week?
Labels: NAILS OF THE WEEK, Nicki Minaj, Nicki Minaj OPI Collection, OPI, OPI Nicki Minaj "Save Me"
I have red nail polish on right now from Essie. Love Essie and Opie products.
I love that blue! I don't like Wet & Wild because they leave my nails stained, so a no no for me, but Sally H is okay. My nails are hot magenta today, lol.
I love glitter nail polish, but it's so hard for me to take off! LOL But this is so pretty!
Cuteee! Love the violet color and the glitter is just right!
Her collection is awesome!!! and that purple is so pretty .


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Hippo Press Articles
This Week's Hippo
"Children Running Through" – Patty Griffin's Long Winter Journey
February 7, 2007 February 7, 2007 Michael Witthaus
Time, inexorably passing and gratefully savored, informs much of Patty Griffin's latest effort, Children Running Through. Fittingly, it arrives amidst this season's coldest days. Throughout the 12-song collection (13 when purchased through iTunes), it's winter – for broken bodies and beaten souls. World-weary resignation courses through this, Griffin's fifth and most fully realized record, and colors the chilly landscape of slow buses, empty fields and sinking vessels like flinty clouds.
Fans of every phase of Griffin's 11-year recording career will find something to like here, from the raw acoustic folk of her earliest work to the lush arrangements on 2004's Impossible Dream. Often, the elements come together in a single song. "No Bad News" opens with busker guitar and ends a Calypso romp, while the Dylanesque "Getting Ready" hints at the stark, percolating fury of Living With Ghosts, then shifts into a loose garage band sound familiar to anyone who's heard a leaked Internet copy of Silver Bell, her unreleased masterpiece.
There are gentler moments, such as "You'll Remember," a sultry torch song that opens the disc, and the spare, nostalgic piano ballad, "Burgundy Shoes." Griffin and producer Mike McCarthy (Spoon) again recruit Americana grand dame Emmylou Harris to sing backup to stunning effect. Framed by elegiac guitar, Harris's brittle, beautiful voice perfectly complements "Trapeze," the tale of an aging circus performer who has loved, lost and even taken a potion to harden her heart, yet still works without a net.
"Trapeze" is a perfect distillation of the storytelling magic heard in earlier works like "Making Pies" and "Top of the World." It's destined to be one she's singing 20 years from now, and make no mistake – people will pay to experience Griffin's timeless magic even then. For more than any songwriter, Patty Griffin crafts her music the way Shakers make chairs, seamlessly joined and breathtaking in their durable beauty.
Griffin's songs are as lean as her frail physique, yet powerful as the train at the center of "Railroad Wings." "There are things you don't know you know," observes Griffin over a lazy guitar cadence, coming to wisdom by song's end: "as far as I can tell everything means nothing/except some things that mean everything." Such small, beautiful jewels are everywhere on this record.
The "children running through" this disc would bury Griffin or worse, reduce her to irrelevancy. "I'm no kid/In a kid's game," she laments at one point, a moment later waiting to "send the ghosts on their way/tell them they've had their day" in "Someone Else's Tomorrow."
But Griffin echoes each funereal moment with one of fierce determination. On the gospel-fueled "Heavenly Day," she sings, "tomorrow may rain with sorrow/here's a little time we can borrow," with the spirited abandon of a young Aretha Franklin. Throughout, she wrestles hope from her darkest moments. In "I Don't Ever Give Up," she states defiantly, "I'm not clean/but I'm not washed up."
Hardly. This record probably won't get much radio airplay, and may be completely ignored by a youth culture that consumes music like Pop-Tarts. But Children Running Through will be passed, hand-to-hand, among the gray believers who know that, as the final track ("Crying Over") intones, "in all of this dreaming of silver and gold/is something to break this winter so cold."
Posted in CD Review, Children Running Through, Mike McCarthy, Patty Griffin, Spoon
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One thought on ""Children Running Through" – Patty Griffin's Long Winter Journey"
Erin Lowther says:
I am going to run out and buy this CD today. Supposedly Barnes and Noble has an additional 2 song CD with it. I was hoping you would have some thoughts on it so I was thrilled to see that you did! This is the most thorough reveiw that I have read. Thanks for the in depth notes on why everyone is hailing this album as possibly her best yet. I can't wait to hear the songs live when I see Patty at the Warfield next month in San Francisco. By the way, tonight (2-11-07)KFOG has a four song set Patty played in their playspace in 2002 on their Acoustic Sunset Show 8 PST
Blue Skies, Erin Lowther
Michael is the primary music and comedy writer for the Hippo, New Hampshire's largest alt-weekly; Michael contributes reviews of current CDs and DVDs, covers concerts large and small, and writes stories about the area music scene. He's a prescient observer of the trends making every word, note and image "local" entertainment. Michael wrote the weekly "Local Rhythms" column for three New Hampshire/Vermont papers: the Eagle Times (Claremont), Connecticut Valley Spectator (Lebanon) and the online Message for the Week (Chester, Vermont) before their abrupt closing on 9 July 2009. He later wrote Local Rhythms for the Compass in Claremont. Email:mwitthaus@gmail.com
Crazed by the Music
Jaded Insider
RAIN: Radio & Internet


BEIJING, China I January 22, 2019 I Beijing-based Immunochina Pharmaceuticals today announced the closing of its $140 million RMB Series C financing (approximately $20.4 million in US Dollars). This financing will enable the company to expand its GMP-grade manufacturing capabilities while continuing clinical trials for its lead IM19 product targeting B-Cell Acute Lymphoblastic Leukemia (B-ALL) and Non Hodgkin's Lymphoma, as well as advancing the development of its pipeline targeting multiple solid and liquid tumors. The financing was led by a syndicate of Chinese and international investors including Shougang Fund, Sherpa Venture Capital, Peter Thiel, Qingzhe Capital, and China Resources Innovative Equity Investment Fund.
Immunochina is committed to the development of best-in-class CAR-T cell therapies and a lentiviral manufacturing platform for the treatment of malignant tumors. The company is reported to be one of only few cell therapy companies in China developing end-to-end research and development capabilities. Founders of Immunochina, Dr. Ting He, Dr. Xin'an Lu and Dr. Feifei Qi, graduated from School of Life Sciences, Tsinghua University. They have been devoted to the basic and translational research in cancer and immunology, and have mastered multiple CAR-T core techniques. Immunochina is backed by a number of Chinese and international investors including Peter Thiel and Legend Capital. For further information, visit www.immunochina.com.


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John B. Goodenough
Winner of the 2019 Nobel Prize in Chemistry
John B. Goodenough, who holds the Virginia H. Cockrell Centennial Chair of Engineering in the Cockrell School of Engineering, has been awarded the 2019 Nobel Prize in Chemistry — jointly with Stanley Whittingham of the State University of New York at Binghamton and Akira Yoshino of Meijo University — "for the development of lithium-ion batteries."
In the words of the Nobel Foundation, "Through their work, they have created the right conditions for a wireless and fossil fuel-free society, and so brought the greatest benefit to humankind."
Goodenough, who was born in 1922, identified and developed the critical materials that provided the high-energy density needed to power portable electronics, initiating the wireless revolution. Today, batteries incorporating Goodenough's cathode materials are used worldwide for mobile phones, power tools, laptops, tablets and other wireless devices, as well as electric and hybrid vehicles.
Watch the Press Conference
On October 14, UT Austin held a press conference that welcomed Goodenough home from London, where he was at the time of the Nobel announcement, and offered local media the opportunity to interview him.
10 Fast Facts About John Goodenough
He still comes to work in his lab every day — and has a laugh that can be heard reverberating through the halls of Texas Engineering buildings. Listen
He has authored several books, including an autobiography titled "Witness to Grace."
He served in WWII as an Army meteorologist.
Goodenough began his career at MIT, where he laid the groundwork for the development of random-access memory (RAM) for the digital computer.
Sony commercialized the battery with his materials in 1991.
He is the recipient of the Japan Prize, the Charles Stark Draper Prize, the National Medal of Science, the Benjamin Franklin Award, the Enrico Fermi Award, the Welch Award, the Copley Medal and many others.
Goodenough was born in Germany in 1922. His students wish him Happy Birthday every year with a cake and celebration. (His birthday is July 25.)
The Royal Society of Chemistry grants an award in his honor, the John B. Goodenough Award for contributions in materials chemistry.
At the University of Chicago — where he earned his master's and doctoral degrees — he studied under Nobel laureate Enrico Fermi and John A. Simpson, both of whom worked on the Manhattan Project.
One of his frequent pieces of advice is to not retire too early. Listen to his conversation with the Nobel Foundation
UT engineer John Goodenough changed our lives with his pioneering battery research — and he isn't done yet.
Read more in UT's alumni magazine, The Alcalde


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Falcon 9 launch timeline for the Starlink 1 mission
May 15, 2019 Stephen Clark
EDITOR'S NOTE: Updated to reflect new launch attempt May 23.
Follow the key events of the Falcon 9 rocket's ascent to orbit 60 satellites for SpaceX's Starlink broadband network.
The 229-foot-tall (70-meter) rocket will lift off Thursday during a 90-minute opening at 10:30 p.m. EDT (0230 GMT Friday) from the Complex 40 launch pad at Cape Canaveral Air Force Station in Florida.
The Falcon 9 will head northeast from Cape Canaveral over the Atlantic Ocean to place the 60 Starlink satellites into a circular orbit around 273 miles (440 kilometers) above Earth.
The Falcon 9's first stage will target a landing on SpaceX's drone ship "Of Course I Still Love You" in the Atlantic Ocean nearly 400 miles northeast of Cape Canaveral.
The first stage booster launching tonight previous flew on two missions — the Telstar 18 VANTAGE launch from Florida in September 2018 and SpaceX's eighth mission for Iridium from California in January.
Data source: SpaceX
T-0:00:00: Liftoff
After the rocket's nine Merlin engines pass an automated health check, hold-down clamps will release the Falcon 9 booster for liftoff from pad 40.
T+0:01:13: Max Q
The Falcon 9 rocket reaches Max Q, the point of maximum aerodynamic pressure, a few seconds after surpassing the speed of sound.
T+0:02:31: MECO
The Falcon 9's nine Merlin 1D engines shut down.
T+0:02:34: Stage 1 Separation
The Falcon 9's first stage separates from the second stage moments after MECO.
T+0:02:41: Stage 2 Ignition
The second stage Merlin 1D vacuum engine ignites for an approximately 6-minute burn to inject the Starlink satellites into a parking orbit.
T+0:03:33: Fairing Jettison
The 5.2-meter (17.1-foot) diameter payload fairing jettisons once the Falcon 9 rocket ascends through the dense lower atmosphere. The 43-foot-tall fairing is made of two clamshell-like halves composed of carbon fiber with an aluminum honeycomb core.
T+0:06:43: Stage 1 Entry Burn Complete
A subset of the first stage's Merlin 1D engines completes an entry burn to slow down for landing. A final landing burn will occur just before touchdown on SpaceX's drone ship "Of Course I Still Love You" around 385 miles (620 kilometers) northeast of Cape Canaveral.
T+0:08:17: Stage 1 Landing
The Falcon 9 rocket's first stage booster touches down on SpaceX's drone ship in the Atlantic Ocean.
T+0:08:46: SECO 1
The Merlin 1D vacuum engine turns off after placing the Starlink satellites in a temporary parking orbit, beginning a 37-minute coast in space.
T+0:46:11: Stage 2 Restart
The Falcon 9's second stage engine ignites again for a 3-second burn to circularize its orbit.
The Merlin 1D vacuum engine shuts down after reaching a target orbit about 273 miles (440 kilometers) high with an inclination of approximately 53 degrees.
T+1:02:14: Begin Starlink Deployments
The 60 flat-panel Starlink satellites, each with a mass of about 500 pounds (227 kilograms) begin deploying from the Falcon 9 rocket's second stage.
Complex 40
Launch Timeline
Reusability
Starlink 1
Citing SpaceX delays, Inmarsat moves satellite launch from Falcon Heavy to Ariane 5
First unpiloted test flight of SpaceX Crew Dragon capsule reset for March 2
Arab and Indian satellites fly aboard Ariane 5


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'To All the Corners of the World' Anime Film Reaches Crowdfunding Goal
posted on 2015-03-17 21:30 EDT by Crystalyn Hodgkins
Film by Black Lagoon director centers on bride living through World War II
The crowdfunding campaign for the anime film of Fumiyo Kono's To All the Corners of the World (Kono Sekai no Katasumi ni) manga reached its goal on Wednesday. The campaign launched in Japan on March 9.
The campaign's goal was to reach 20 million yen (about US$164,873) in funding, and as of press time the campaign had raised 20,354,000 yen (US$167,788) from 1,736 backers.
The crowdfunding campaign offers six tiers of rewards from 2,000 yen (about US$17, with a member's pin badge and a letter from the lead character Suzu) to 1,000,000 yen (about US$8,000 with the badge, the letter, an invitation to one of three production support member meetings in July, and a name listing in the ending credits). The campaign will end on the Makuake website on May 29.
The award-winning story of Kono Sekai no Katasumi ni follows a bride named Suzu Urano as she moves to her new life in Kure City on the coast of Hiroshima Prefecture. Suzu perseveres through World War II with pluck and determination. The tagline on the site for the film's production support members reads:
Meals.
Sketchbook.
Shōwa Years 19 and 20…
Kure, Hiroshima…
In that place and time was my humble daily life.
Director and writer Sunao Katabuchi (Mai Mai Miracle, Black Lagoon) had announced the feature film in 2012. Early concept art featured designs by Chie Uratani (Black Lagoon: Roberta's Blood Trail, Mai Mai Miracle, Tekkonkinkreet animation director), and the staff completed the scenario and storyboards. The studio MAPPA (Kids on the Slope, Terror in Resonance) is animating the film, and Genco is producing.
JManga had released Kono's manga in English online. The manga series won an Excellence Prize in the 13th Japan Media Arts Festival, and it already inspired a live-action television special starring Keiko Kitagawa (live-action Sailor Moon's Sailor Mars, Paradise Kiss) as Suzu Urano in 2011. Last Gasp Publishing and jaPress released Kono's manga Town of Evening Calm, Country of Cherry Blossoms in North America.
[Via Yaraon!]


Shared Houses Featured on Shinjuku, Shibuya, Roppongi, Close to Station. Narrow your results by location and feature. Sort by price, vacancies, and new is also helpful.
3	mins to Shinjuku-sanchome Station	(the Marunouchi line) on foot.
4	mins to Ningyo-cho Sta	(the Hibiya Line) on foot.
Shared Houses Featured on Shinjuku, Shibuya, Roppongi, Close to Station.
5 mins to Higashishinjuku Sta. on the Toei Oedo Line on foot.
1 mins to Shimoochiai Sta. on the Seibu Shinjuku Line on foot.
3 mins to Takadanobaba Sta. on the JR Yamanote Line on foot.
You can choose one! I hope you would find the best option from them. Please inquiry the detail.
10 mins to Tokyo sta on the JR line. Marunouchi Line on foot.
8 mins to Shiba kouen Station on the Mita line on foot.


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class UpdateBuildsForCommonSense < ActiveRecord::Migration
  def change
    execute "UPDATE `builds` SET `ssh_server_port`    = SUBSTRING_INDEX(`ssh_server_address`, ':', -1)"
    execute "UPDATE `builds` SET `ssh_server_address` = SUBSTRING_INDEX(`ssh_server_address`, ':', 1)"

    execute "UPDATE `builds` SET `target_port`    = SUBSTRING_INDEX(`target_address`, ':', -1)"
    execute "UPDATE `builds` SET `target_address` = SUBSTRING_INDEX(`target_address`, ':', 1)"
  end
end

redpajama_set_name: RedPajamaGithub


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Jan 23 Immortal Hulk #12 // Review
Adult, Horror, Marvel Comics, Nostalgia, Sci Fi
The Hulk's world is changing with each passing issue of The Immortal Hulk, but #12, written by Al Ewing, with pencils by Joe Bennett and Eric Nguyen, inks by Ruy Jose (and Nguyen again), and colors by Paul Mounts, brings the biggest changes yet. Previously, Absorbing Man was tricked into absorbing Hulk's gamma energy, opening the "Green Door" to what is essentially Hell. Now, Banner has been split from his monstrous alter ego, leaving the Green Goliath to wander Hell with reporter Jackie McGee.
Ewing finally shines the spotlight on Banner's father, who was revealed issues ago to be manipulating Hulk from beyond the grave on behalf of a mysterious, dark entity. Now that he's managed to manipulate the land of the living into opening the "Green Door" to Hell, he's spending his time explaining himself to his son (who may, or may not, be able to hear him). Ewing masterfully weaves his dark tale of an evil entity manipulating Banner, the Hulk, and his father, altering the history of old Jade Jaws for all time. Whether these retcons truly stand the test of years to come is unknown at the moment, but Ewing is doing his best to make sure we'll be talking about them for the foreseeable future.
If every great comic book writer adds something of his/her own to a story in their run on a title, then Ewing is doing the work of several writers. In every chapter of The Immortal Hulk, Ewing seems to add some new wrinkle to the character, whether it's as small as a personality tick, or as large as a whole new identity for the Hulk. This issue is no different. The very nature of Hulk and Bruce, and their relationship to one another, is being called into question, and it's unlikely Ewing will leave this book without making the readers redefine how they think of the character. Is he a misunderstood monster, created by an accident of science, or is there something more sinister to that accident, and the creature that was born from it? Ewing will, no doubt, keep people guessing for some time, but the journey to the answers is one hell of a ride.
Bennett, once again, proves he was born to draw this book, but he's joined this issue by another talented penciler/inker, Nguyen, who handles all of the art duties, except colors, on the flashback portions. Nguyen's pencils and inks work well with the dark subject matter in his parts of the book, and add a very welcome creepiness to Banner's father's memories. Jose, who inks the rest of the book, as well as Mounts on colors, work their usual magic, elevating this title into one of the best Marvel has to offer, art-wise.
If you're not reading this book, you are doing yourself a disservice. Even if you've never been a big fan of the Hulk, give it a try. Ewing is crafting a story that is somehow, everything a classic Hulk fan would love, while still being completely different than anything that's come before it. This will be a beloved piece of Hulk history years from now, if there's any justice in the world. Jump aboard now, while history is still being made.
Grade A+
Al Ewing, Joe Bennet, Eric Nguyen, Ruy Jose, Paul Mounts, Green Door, The Incredible Hulk, The Immortal Hulk, Hulk, Bruce Banner
Jan 23 Shazam! #2 // Review
Jan 23 Aquaman #44 // Review
Mar 21 The Immortal Hulk #15 // Review
May 29 The Immortal Hulk #18 // Review
Jul 3 The Immortal Hulk #20 // Review


The Cavaliers had some friends in high places, as they toured USO bases and performed for many 'foriegn dignitaries'. They also played dances throughout southern Ohio.
The Cavaliers recorded one 45 at Magnetic, covers of "You Are My Sunshine" and "Unchained Melody". Both sides featured the band's signature Wurlitzer piano sound.


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Q: Prevent selection being greyed out in iframe in Firefox without using contenteditable In Firefox 3 and later (and probably older versions), selecting content within an iframe always seems to use the grey selection background colour used for a document that doesn't currently have focus, even if the iframe does have focus. The only exception I have been able to find is when the content within the iframe is editable. This is not the case in other browsers. Here's an example illustrating this:
http://jsfiddle.net/97Vjz/
This unfortunately prevents styling the selection within an iframe using the ::-moz-selection CSS pseudo-element because it only applies to non-grey selections:
http://jsfiddle.net/YYXSY/1/
My question is: is it possible to prevent an iframe's selection being grey in Firefox without using contenteditable / designMode?
UPDATE
This only seems to happen on dynamically written iframes: using a separate file and the src attribute solves the problem. However, I do need it to work with dynamically written iframes.

A: I just tried to reproduce the problem with a "real" page as iframe content and then it works like you want: blue colored selection! (FF 5.0)
see: http://jsfiddle.net/97Vjz/8/
It seems only generated content has this problem, so you could make a page (php/asp(x)) that generates the content for you to circumvent the problem.
Another solution to use javascript generated content is to load it with src="javascript:''" (actually this is Tim's own solution from the comments below.)
A simple example script: http://jsfiddle.net/97Vjz/9/
 iframe.src='javascript:\'' + content + '\'';

A: There is a property of the iframe exposed in Firebug's DOM inspector contentDocument->designMode which is set to false for you iFrames.  Forcing it to true through the DOM inspector enables the blue highlight you're after.

A: Hypothesis: It seems that for dynamically written iFrames, either a XUL Iframe is rendered or the Gecko engine doesn't honor the styles.
Short of submitting a bug, the only workaround I can see is to wrap our contents in a textarea and style it to make it 'invisible': http://jsfiddle.net/mrchief/YYXSY/19/


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Empowering Lives Through Heart Work
Emily Koh Hui Yu
Physiotherapist, SPD (formally known as Society for the Physically Disabled)
Meet Emily Koh, a Physiotherapist who desired in giving back to society upon graduation led her to join the social service. This is her story.
What sparked your interest in social service?
It was the desire to give back to society. I always knew that I wanted to join either healthcare or social service upon graduation. In the end, I decided to join social service as it serves the stratum of society that is most vulnerable and requires the most support. I wanted to contribute by empowering people's lives.
How has the social service scholarship enabled you to fulfil this dream?
The scholarship provides opportunities to intern and to rotate across social service agencies in Singapore. This enables us to gain a more holistic understanding of social service and learn from senior professionals to become better at what we do.
Now that you have joined the social service sector, what are your current
roles and responsibilities?
I am a physiotherapist at SPD. Formerly known as the Society for the Physically Disabled, I work with people to help them to be self-reliant and independent. To extend holistic support to our clients, I constantly collaborate with other social service professionals to help clients improve their physical, psychosocial, emotional, and social well-being.
What is the biggest challenge you face in your work then, and
how do you overcome them?
The biggest challenge I face with some clients is when they lack the motivation to participate in physical activity at home and within their community. On my part, I work with clients, their families, and other professionals to try to identify ways that they can participate in community activities at activity centres and support groups. The joy from interacting with my clients is the motivation that keeps me going.
On the other hand, what is one memorable experience from
your career?
One of my clients teared up during a meeting with his occupational therapist, his daughter and me. He thanked us for our collaborative efforts. To me, that meant that I was on the right track because we were providing what he truly needed and had made a positive impact on his life as a team.
What advice would you give to those who are considering the
social service scholarship?
I would encourage them to learn more about what working in the social service is like before applying for the scholarship. The best way to do this is to visit various social service agencies or speak to people from social service to find out more. The industry is a growing sector with several career tracks for social service professionals to embark on. There are plenty of opportunities for personal growth and career development! We are professionals who are proudly empowering Singapore's people to lead dignified lives. Discover what it means to be part of the Tribe and career opportunities within the social service.
We are professionals who are proudly empowering Singapore's people to lead dignified lives. Discover what it means to be part of the Tribe and career opportunities within the social service.
Emily converses with a client in a session.
"My parents and grandparents consistent acts of kindness spurred my decision to join social service."
Dylan Koh
SPD (formally known as Society for the Physically Disabled)
"My beliefs and values reminded me to reach out to the vulnerable and support them in meaningful ways as a Psychologist."
Jeremy Heng
Singapore Children's Society
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Copyright©2021 Social Service Tribe. All Rights Reserved. Last updated on 1 January 2021


Timing : Every Saturday from 04:00 - 6:00 pm.
The Children Fellowship is an outreach ministry for children both saved and unsaved. It serves to bring the gospel to the unsaved young ones and also to help in the spiritual development of those who have already accepted Jesus Christ as Saviour. It caters to children from nursery age to Primary 6. The children are divided by age into 4 subgroups - Seekers (N2 to K2) / Keepers (P1 & P2)/ Helpers (P3&4) / Givers (P5& 6).
The programme consists of Council Time, Handbook Time and Games. During Council Time, the children receive messages on biblical truths or listen to stories leading to spiritual growth. During the Handbook Time, the children learn bible verses and do worksheets that will help them apply what they have learnt. Even while playing Games, the children are encouraged to show discipline and team-work. Besides regular Saturday meetings, every year we organize outings during school holidays and fun-fair style Games Day.
To further encourage the children, there is an award system that rewards the children for attendance, good behaviour , completing Handbook sections etc. There will be a Store Day once every month, where the children can exchange their awards for snacks or useful items.