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Tag Archives: C diff research and developnent
Researchers Make Chemical Changes In the InsP6 Inhibitor To Improve Its Hydrogen Bonding Capabilities With C. difficile Toxins
Infections with bacterium Clostridium difficile have rapidly become a significant medical problem in hospitals and long-term care facilities. The bacteria cause diarrhea and life-threatening inflammation of the colon by producing toxins that kill the endothelial cells that form the lining of the gut.
Although a natural inhibitor of these toxins, called InsP6, works in the test tube, it is not very efficient when administered orally.
Traditional methods to optimize InsP6 have until now not been successful, but researchers at Baylor College of Medicine have discovered that changing one atom in InsP6 can increase its ability to neutralize the toxins by 26-fold.
The results appear in Science Advances.
"The toxins, called TcdA and TcdB, are very large molecules that kill the cells very efficiently," said Dr. Tor Savidge, associate professor of pathology and immunology and of pediatrics, director of the Savidge Lab at the Texas Children's Microbiome Center and senior author of the paper. "It's like delivering a warhead into the cell. The toxins bind to the cell and the cell internalizes them in a sack of cell membrane called endosome. Not all of the toxin will exit this sack to kill the cell, just the little warhead pokes its head out. Another section of the toxin senses when the warhead is outside the sack and cleaves it. The warhead is released, interferes with basic functions and kills the cell," said Savidge.
To neutralize the toxins, the researchers targeted the section that senses when the warhead is inside the cell, called allosteric modulator. "The strategy we have tried is to make the toxin 'think,' before it binds to and enters the cell, that the warhead is ready to be released, so it releases it prematurely," said Savidge. When the warhead is released outside the cell, it is neutralized. InsP6, the toxins' natural inhibitor, works this way, but is not very efficient.
Finding molecules that would bind to the allosteric modulator and trigger the premature release of the warhead involved analyzing and testing half a million molecules listed in large databases. Dr. Numan Oezguen, a member of the Savidge Lab, used virtual drug screening to sift through the databases to identify candidate molecules that most likely would bind to the allosteric modulator. One of his screening strategies consists of creating virtual 3-D structures of the molecules, projecting them on a large screen and using 3-D glasses to determine the most likely interactions between molecules. The molecules whose virtual analysis suggested they would bind to the allosteric modulator were then tested in the lab.
"We found that allosteric mechanisms are very complicated," said Savidge. "You can find something that binds and you think, well, this is probably a good candidate for this, but it's not right. It binds, but it doesn't trigger the premature release of the warhead."
Far from discouraging their efforts, the results motivated the researchers to better understand what makes interactions between molecules stronger or weaker. Their comprehensive analysis of numerous molecules provided insights into how water contributes to molecular interactions, in particular those involving hydrogen bonds, one of the most important bonds between molecules. The roles of water and hydrogen bonding had not been considered in this way before.
"When you take water into consideration you need to acknowledge that it can form hydrogen bonds, which may or may not compete or interfere with those formed between other molecules such as C. difficile toxins and their inhibitors, which interact in the gut, surrounded by water," said Savidge.
"Before we considered the role of water, the predominant idea was that to strengthen the interaction between molecules the ability to form hydrogen bonds had to be made as strong as possible in the drug. It turns out this is not the case," said Oezguen. Many times drugs designed to be able to make strong hydrogen bonds bind poorly to their targets.
The researchers discovered that to enhance the binding of a drug to its target, both sides of the hydrogen bond, the side on the drug and the one on the target, have to have either significantly stronger or significantly weaker hydrogen bonding capabilities.
On the other hand, a mixed strong-weak hydrogen bond pairing decreases the overall binding of the drug to its target, in some cases by 3 million fold. The decrease in binding is the result, the researchers propose, of water molecules forming hydrogen bonds with the drug and its target, therefore preventing the drug and the target from forming hydrogen bonds between them.
With all this information in hand, the researchers proceeded to make chemical changes in the InsP6 inhibitor to improve its hydrogen bonding capabilities with
C. difficile toxins.
One of the modifications, changing one single atom in InsP6, strengthened InsP6 binding to the allosteric modulator by 26-fold. This observation builds on a report published by Savidge in Science last year exploring the role of water interactions in the origin of enzymatic catalytic power.
Plans are currently underway to exploit these fundamentally new concepts in the precision design of future therapeutic applications.
Other contributors to this work are Deliang Chen, now in Gannan Normal University, China, who contributed conceptual and theoretical proof of the hydrogen bonding pairing principle; Petri Urvil from Baylor performed lab studies; Colin Ferguson from Echelon Biosciences, Inc. synthesized the more efficient inhibitor; and Sara Dann from the University of Texas Medical Branch in Galveston, contributed animal studies.
This work was supported by grants RO1AI100914 and DK56338 from the National Institute of Allergy and Infectious Diseases and the National Institute of Diabetes and Digestive and Kidney Diseases at the NIH, and the National Science Foundation of China (21473041).
Source: https://www.bcm.edu/
To read the article in its entirety click on the following link:
http://www.azom.com/news.aspx?newsID=45377
This entry was posted in C. diff. Research & Development, C. diff. Research Community and tagged allosteric modulator, Baylor College of Medicine, C diff research and developnent, C difficile research and development, C difficile toxins, Clostrideum difficile, Colin Ferguson Echelon Biosciences, Deliang Chen Gannan Normal University China, Dr Numan Oezguen, Dr Tor Savidge, hydrogen bonding, InsP6, IP6, Petri Uryl Baylor, Sara Dann University of Texas Medical, Savidge Lab, Texas Children's Microbiome Center on March 29, 2016 by cdifffoundation.
C. diff. Spores and More Global Broadcasting Network Welcomes Guests; Dr. Michael Stecher, Dr. Sushma Shivaswamy, and Mr. Kelly Thornburg of XBiotech
XBiotech will discuss their novel True Human ™ approach on Tuesday, February 2nd at
10 a.m. Pacific Time,, 11 a.m. Mountain Time,
12 p.m. Central Time, 1 p.m. Eastern Time.
on C. diff. Spores and More™" Global Broadcasting Network – an educational program dedicated to C. difficile Infections and more — brought to you by VoiceAmerica and sponsored by Clorox Healthcare
http://www.voiceamerica.com/show/2441/c-diff-spores-and-more
This episode introduces XBiotech, developer of True Human ™ therapeutic antibodies. XBiotech has an exciting pipeline of product candidates in various areas of medicine. The Company recently anounced the launch of a research and development program to develop a first-in-class oral monoclonal antibody against Clostridium difficile (C. diff. ) infection. The Company will discuss the need for an effective C. difficile therapy, their novel approach to treating the infection as well as efficiency in their manufacturing technology.
Join guests Dr. Michael Stecher,MD, Medical Director, Dr. Sushma Shivaswamy, Ph.D., Vice President of Research and Development and Mr. Kelly Thornburg, Senior Vice President of Operations as they discuss how XBiotech is pioneering a new era in the discovery and development of targeted antibodies therapeutics.
XBiotiech is rethinking the way medicines are discovered and commercialized– from pioneering ways to create safer drugs that harness our natural immunity to disease, to developing technology that enables rapid transition from discovery to large-scale manufacturing. "At XBiotech we believe there is vast potential for next generation antibody therapies derived from natural immunity to disease. We believe our innovation in technology and in the clinic enables us to bring our new discoveries to patients more efficiently than any other bio-pharmaceutical developer in the industry. "
This entry was posted in C. diff. Spores and More Global Broadcasting Network and tagged Biopharmaceutical, C diff research and developnent, C difficile research and development, C. diff. spores and more, C. difficile Therapy, Clostridium difficile research and development, Dr Michael Stecher, Dr Sushma Shivaswamy, Healthcare, Mr Kelly Thornburg, True Human Therapeutic Antibodies, XBiotech on February 1, 2016 by cdifffoundation.
Michael G. DeGroote School of Medicine at McMaster Researchers Discover New Superbug Test With Quick Diagnosis
McMaster researchers have come up a way for inventing molecule probes to quickly identify deadly bacterial strains of infectious disease.
The find, published as a "hot paper" by a German scientific journal because of its importance, shows promise for detecting specific strains of bacteria and tracking their specific trail of illness.
"With this new technology we will be able to develop molecular tools to recognize any superbug down to the specific strain, and there will be many wide-ranging applications," said Yingfu Li, principal investigator and a professor of biochemistry and biomedical sciences for the Michael G. DeGroote School of Medicine at McMaster.
The scientists have found a way to make DNAzymes, or single-stranded catalytic DNA molecules from a simple test tube technique that allows for isolation of rare DNA sequences with special functions.
The research team's first success was the development of a molecular probe that precisely recognizes the strain which caused the 2011 Hamilton, Ont. outbreak of Clostridium difficile infection. This strain was very infectious, resistant to antibiotics and even fatal to some patients. Instead of having to do several different tests to narrow down to a positive identification of the specific strain, the researchers can now quickly pinpoint this superbug using their new molecular probe.
"This sets up the stage for numerous other applications where we can exploit synthetic DNAzyme probes for diagnosing infectious disease," said Li.
The test can be done in less than an hour, compared to the current 48 hours, allowing for rapid, more accurate treatment of patients.
"This technology can be extended to the further discovery of other superbug strain-specific pathogens. For example, such technology would prove useful in the identification of hypervirulent or resistant strains, implementation of the most appropriate strain-specific treatments and tracking of outbreaks", said Bruno Salena, a co-author of the study, an associate professor of medicine for the Michael G. DeGroote School of Medicine and a gastroenterologist with Hamilton Health Sciences.
"This technology is inexpensive, accessible without a lab, and will ultimately be adaptable to identify not just many other bacteria or viruses, but even other diseases," he said.
To read the article in its full version click on the link below:
http://m.phys.org/news/2015-12-infectious-disease-quick-diagnosis.html
This entry was posted in C. diff. Research & Development, C. diff. Research Community and tagged Associate Professor Bruno Salena, C diff research and developnent, C difficile research and development, DNAzyme, McMaster, Michael G. DeGroote School of Medicine, Professor Yingfu Li, Superbug Technology on January 19, 2016 by cdifffoundation.
Asymptomatic carriers of toxigenic C. difficile in long-term care
Asymptomatic carriers of toxigenic C. difficile in long-term care facilities: a meta-analysis of prevalence and risk factors.
Ziakas PD1, Zacharioudakis IM1, Zervou FN1, Grigoras C1, Pliakos EE1, Mylonakis E1.
The impact of Clostridium difficile colonization in C. difficile infection (CDI) is inadequately explored. As a result, asymptomatic carriage is not considered in the development of infection control policies and the burden of carrier state in long-term care facilities (LTCFs) is unknown.
To explore the epidemiology of C. difficile colonization in LTCFs, identify predisposing factors and describe its impact on healthcare management.
PubMed, Embase and Web of Science (up to June 2014) without language restriction, complemented by reference lists of eligible studies.
STUDY SELECTION:
All studies providing extractable data on the prevalence of toxigenic C. difficile colonization among asymptomatic residents in LTCFs.
DATA EXTRACTION:
Two authors extracted data independently.
STATISTICAL METHODS:
The pooled colonization estimates were calculated using the double arcsine methodology and reported along with their 95% random-effects confidence intervals (CIs), using DerSimonian-Laird weights. We assessed the impact of patient-level covariates on the risk of colonization and effects were reported as odds ratios (OR, 95% CI). We used the colonization estimates to simulate the effective reproduction number R through a Monte Carlo technique.
Based on data from 9 eligible studies that met the specified criteria and included 1,371 subjects, we found that 14.8% (95%CI 7.6%-24.0%) of LTCF residents are asymptomatic carriers of toxigenic C. difficile. Colonization estimates were significantly higher in facilities with prior CDI outbreak (30.1% vs. 6.5%, p = 0.01). Patient history of CDI (OR 6.07; 95% CI 2.06-17.88; effect derived from 3 studies), prior hospitalization (OR 2.11; 95% CI 1.08-4.13; derived from 3 studies) and antimicrobial use within previous 3 months (OR 3.68; 95% CI 2.04-6.62; derived from 4 studies) were associated with colonization. The predicted colonization rate at admission was 8.9%.
Asymptomatic carriage of toxigenic C. difficile represents a significant burden in LTCFs and is associated with prior CDI outbreaks in the facility, a history of CDI, prior hospitalization and antimicrobial use. These findings can impact infection control measures at LTCFs.
To read this article/abstract in its entirety click on the link below:
This entry was posted in C. diff. for Healthcare Providers, C. diff. Research & Development, C. diff. Research Community and tagged c diff, C diff research and developnent, C difficile research and development, C. diff. for healthcare, C. difficile in Long Term Care, C. difficile research, Clostridium difficile, Clostridium difficile research and development, Long term care on November 3, 2015 by cdifffoundation.
C. diff. Research and Development Community October 2015
Here is the latest from the Clostridium difficile research community
Serum 25-hydroxyvitamin D levels are not associated with adverse outcomes in Clostridium difficile infection
Clostridium difficile infection (CDI) is a significant source of healthcare-associated morbidity and mortality. This study investigated whether serum 25-hydroxyvitamin D is associated with adverse outcomes from CDI. Patients with CDI were prospectively enrolled. Charts were reviewed and serum 25-hydroxyvitamin D was measured. The primary outcome was a composite definition of severe disease: fever (temperature >38°C), acute organ dysfunction, or serum white blood cell count >15,000 cells/µL within 24-48 hours of diagnosis; lack of response to therapy by day 5; and intensive care unit admission; colectomy; or death within 30 days. Sixty-seven patients were included in the final analysis. Mean (±SD) serum 25-hydroxyvitamin D was 26.1 (±18.54) ng/mL. Severe disease, which occurred in 26 (39%) participants, was not associated with serum 25-hydroxyvitamin D [odds ratio (OR) 1.00; 95% confidence interval (CI) 0.96-1.04]. In the adjusted model for severe disease only serum albumin (OR 0.12; 95%CI 0.02-0.64) and diagnosis by detection of stool toxin (OR 5.87; 95%CI 1.09-31.7) remained independent predictors. We conclude that serum 25-hydroxyvitamin D is not associated with the development of severe disease in patients with CDI.
For full article click on the link below:
http://www.pagepress.org/journals/index.php/idr/article/view/5979
Clostridium difficile is a Gram-positive spore-forming pathogen and a leading cause of nosocomial diarrhea. C. difficile infections are transmitted when ingested spores germinate in the gastrointestinal tract and transform into vegetative cells. Germination begins when the germinant receptor CspC detects bile salts in the gut. CspC is a subtilisin-like serine pseudoprotease that activates the related CspB serine protease through an unknown mechanism. Activated CspB cleaves the pro-SleC zymogen, which allows the activated SleC cortex hydrolase to degrade the protective cortex layer. While these regulators are essential for C. difficile spores to outgrow and form toxin-secreting vegetative cells, the mechanisms controlling their function have only been partially characterized. In this study, we identify the lipoprotein GerS as a novel regulator of C. difficile spore germination using targeted mutagenesis. A gerS mutant has a severe germination defect and fails to degrade cortex even though it processes SleC at wildtype levels. Using complementation analyses, we demonstrate that GerS secretion, but not lipidation, is necessary for GerS to activate SleC. Importantly, loss of GerS attenuates the virulence of C. difficile in a hamster model of infection. Since GerS appears to be conserved exclusively in related Peptostreptococcaeace family members, our results contribute to a growing body of work indicating that C. difficile has evolved distinct mechanisms for controlling the exit from dormancy relative to B. subtilis and other spore-forming organisms.
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005239
XBiotech the world's leading developer of next-generation True Human™ therapeutic antibodies, announced today the launch of a research and development program to develop a first-in-class oral monoclonal antibody against Clostridium difficile (C. difficile) infection. Using its proprietary True Human technology, the Company has begun screening human blood samples from donors to identify and clone a therapeutic antibody candidate from individuals with natural immunity to C. difficile infection.
http://www.benzinga.com/news/15/10/5942247/xbiotech-initiates-program-to-develop-antibody-against-clostridium-difficile#ixzz3pyDmXwuw
Predominance of Clostridium difficile ribotypes 012, 027 and 046 in a university hospital in Chile, 2012
In a 1-year survey at a university hospital we found that 20·6% (81/392) of patients with antibiotic associated diarrohea where positive for C. difficile. The most common PCR ribotypes were 012 (14·8%), 027 (12·3%), 046 (12·3%) and 014/020 (9·9). The incidence rate was 2·6 cases of C. difficile infection for every 1000 outpatients.
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10011117&fileId=S0950268815002459
Microbiota Changes Predict Treatment Failure
Infection with C. difficile is associated with several adverse outcomes including treatment failure (5% to 35%) but researchers do not know what clinical factors can predict this failure.
Reporting at the American College of Gastroenterology Scientific Meeting in Honolulu, a Mayo Clinic team of researchers looked at which gut microbiota signatures might be useful in determining whether patients will get better.
They defined treatment failure as a non-response to treatment with vancomycin for four days or metronidazole for five days. They looked at 889 patients with primary C. dif in infection (CDI) of whom 60.2% were women and the median age was 54 years. Of these 7% had severe CDI, 70.5% had been treated with metronidazole, 23.8% with vancomycin, and 5.6% with a combination.
Overall 12.5% failed treatment and the rates were similar with each drug.
The researchers looked at clinical factors that might have predicted the failures–age, sex, obesity, prior antibiotic use, and other factors. They found no correlation between having those factors and failing treatment. They did find that patients who responded to treatment had higher quantities of certain bacteria, for instance Faecalibacterium and Bacteroides.
Conversely, the patients who failed treatment had more Streptococcus and Clostridium.
The authors suggest that analyzing these changes in microbiota could be useful. "Gut microbiota signatures may be used to predict treatment response in the absence of reliable clinical predictors," said Sahil Khanna, MBBS, M S in presenting the study.
http://www.hcplive.com/conference-coverage/acg-2015/c-dif-microbiota-changes-predict-treatment-failure-
This entry was posted in C. diff. Research & Development, C. diff. Research Community and tagged C diff research and developnent, C difficile research and development, Clostridium difficile research and development, Microbiota research, XBiotech on October 29, 2015 by cdifffoundation.
C. diff. Research and Development – August 2015
Microbiota and Subsequent Effects on Colonization Resistance against Clostridium difficile
Alyxandria M. Schubert, Hamide Sinani, Patrick D. Schloss
To read this paper in its entirety :
http://mbio.asm.org/content/6/4/e00974-15.short?rss=1&ssource=mfr
The gastrointestinal tract harbors a complex community of bacteria, known as the microbiota, which plays an integral role preventing its colonization by gut pathogens. This resistance has been shown to be crucial for protection against Clostridium difficile infections (CDI), which are the leading source of hospital-acquired infections in the United States. Antibiotics are a major risk factor for acquiring CDI due to their effect on the normal structure of the indigenous gut microbiota. We found that diverse antibiotic perturbations gave rise to altered communities that varied in their susceptibility to C. difficile colonization. We found that multiple coexisting populations, not one specific population of bacteria, conferred resistance. By understanding the relationships between C. difficile and members of the microbiota, it will be possible to better manage this important infection.
The spore-associated protein BclA1 affects the susceptibility of animals to colonization and infection by Clostridium difficile
http://onlinelibrary.wiley.com/doi/10.1111/mmi.12611/abstract
The paper shows that so-called "hypervirulent" strains of C. difficile, such as the 027 ribotype strains, are actually less infectious than the existing strains of C. difficile carried in humans and animals. We were able to show this by characterizing one gene of C. difficile that encodes the BclA1 protein. BclA1 is involved in the early stages of colonization and its presence enables spores of C. difficile to colonise the host. When this protein is removed or truncated the ability of spores to colonise is much reduced. This then raises the question of how hypervirulent strains are more efficient at infecting a host, in other words, how they can be more virulent. The answer is probably the hypervirulent strains are able to produce more toxins. This work raised the concept that C. difficile is similar to influenza. For example, with influenza the most infectious influenza strains do not normally cause fatality (ie, the seasonal flu strains). On the other hand, the pandemic strains (avian influenza) are not very infectious (that is, they spread poorly) yet when they do infect they cause a dangerous infection more likely to lead to fatality. C. difficile we reason behaves in a similar way, the hypervirulent strains are poorly infectious yet cause a more potent infection while highly infectious strains cause a less potent infection. We plan to use this knowledge to type new isolates of C. difficile and assess their risk to humans.
Professor Simon M. Cutting
School of Biological Sciences,
Bourne Laboratories, 4-26,
Egham,
Surrey TW20 OEX
This entry was posted in C. diff. Research Community and tagged c diff research, C diff research and developnent, Clostridium diffiicle, Microbiome Research, Spore-associated protein BcIA1 on August 15, 2015 by cdifffoundation.
C. diff. cases higher in the Spring according to a study conducted by researchers at the University of Texas at Austin
People may be more likely to get infected with the sometimes deadly gut infection called "C. diff" during the spring, according to a new study.
Researchers analyzed information from people who were discharged from U.S. hospitals between 2001 and 2010. During this time period, about 2.3 million people were released from a hospital following an infection with Clostridium difficile, which can cause severe diarrhea, and frequently comes back after treatment.
In the spring, there were about 62 cases of C. difficile for every 10,000 people discharged from the hospital, the study found.
In winter and summer, there were 59 C. difficile cases per 10,000 people discharged from the hospital, and the lowest rate was seen in the fall, when there were 56 C. difficile cases per 10,000 hospital discharges.
Most cases of C. difficile occur after people take antibiotics, which disturb the normal balance of gut bacteria, giving harmful bacteria the chance to overgrow. It's possible that the rates of C. difficile infection are the highest in the spring because people use more antibiotics during the winter months to treat respiratory infections, the researchers said. There can be a one- to two-month lag between the time a person takes antibiotics, or antimicrobials, and when he or she develops a C. difficile infection.
The new finding "emphasizes the importance of antimicrobials' use as a risk factor" for C. difficile infections, the researchers said. The results also underscore the need to better control infections and use antibiotics only when they are needed," particularly during high-risk seasons and in high-risk areas, the researchers wrote.
The study also found that, over the 10-year study period, the rates of C. difficile infection were the highest in the Northeast, where the overall rate was 80 cases per 10,000 hospital discharges, followed by the Midwest (64 cases per 10,000 hospital discharges), the South (50 cases per 10,000 hospital discharges) and the West (48 cases per 10,000 hospital discharges).
These regional differences in C. difficile could be partly due to differences in the number of older adults in each area, with the Northeast possibly having a higher proportion of older adults, the researchers said. Older adults are at increased risk for C. difficile infection. In fact, the overall rate of C. difficile infections during the study was 160 cases per 10,000 hospital discharges among adults age 65 and older, compared with 35 cases per 10,000 discharges in adults under 65 and 12 cases per 10,000 discharges in children.
"Our findings indicate the need for additional resources when and where health care burdens are highest," the researchers said.
The study, conducted by researchers at the University of Texas at Austin, is published in the May issue of the American Journal of Infection Control.
To read article in its entirety click on the following link:
http://news.yahoo.com/deadly-gut-bacteria-infections-peak-spring-145430313.html;_ylt=A0LEVxPSvkNV1ooA0MFXNyoA;_ylu=X3oDMTEza2t0ajNjBGNvbG8DYmYxBHBvcwMxBHZ0aWQDVklQNTY0XzEEc2VjA3Nj
This entry was posted in C. diff. Research & Development, C. diff. Research Community and tagged c diff, C diff research and developnent, C difficile study, Clostridium difficile, University of Texas at Austin on May 1, 2015 by cdifffoundation.


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The Walking Dead: Saints & Sinners Game
The Walking Dead: Saints & Sinners Articles
15 Upcoming Horror Video Games to be Excited About in 2020
by Ty Arthur
From a VR excursion into The Walking Dead to a bloody platformer where you get to play as the amorphous blob of a monster, there are some truly killer horror games due to land in 2020!
No one has reviewed The Walking Dead: Saints & Sinners yet!
Played The Walking Dead: Saints & Sinners yet? What did you think?

redpajama_set_name: RedPajamaCommonCrawl


Future 2014 and 2015 trips in the works!
Sue Smith Vacations/Vacation Valet teamed up with our rep Kenny Judd this morning from Collette Vacations to discuss future groups trips for 2014 and even 2015 too! We can't wait to show you guys what we have planned for in 2014.
Can anyone guess the name of this castle? This is one of the landmarks that we may be visiting next year!


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Peter Donnelly
Sir Peter Donnelly FMedSci FRS
wwwhttp://www.stats.ox.ac.uk/people/academic_staff/peter_donnelly
Peter Donnelly is developing and applying statistics and probability theory to understand how the human genetic code evolves and to identify what makes some people prone to certain diseases. As an expert on DNA, Peter has also extensively commented on how DNA evidence is misunderstood in criminal court cases and advised on best practice.
He has led collaborations of hundreds of scientists in analysing DNA from thousands of people. He has also made major contributions to similar international studies, including the Human Genome and HapMap projects. In addition, Peter has conducted related research into recombination — how genes from each parent 'mix and match' as they are passed on to their offspring.
Peter's important work is highly regarded around the world. Amongst his many awards are the Mitchell Prize of the American Statistical Association, the Guy Medal in Silver of the Royal Statistical Society and the 2008 Weldon Memorial Prize.
Professional positions
Director, Wellcome Trust Centre For Human Genetics, Smith School of Enterprise and the Environment
Statistics and Operational Research
Organismal biology, evolution and ecology


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Home > News > Next step top 20- Mo Zhang is staring at Tokyo
At the recent World Team Table Tennis Championships, Zhang won all of her matches - in Division 2. 11-0 was her record, keeping the Canadian team comfortably in Division 2.
While Halmstad may not have been her greatest challenge, Mo Zhang showed her ambition at the 2017 Uncle Pop Women's World Cup where she challenged WR#1 Zhu Yuling (CHN) to a to a duel which the Chinese star eventually decided in her favour, but the spectators could see that the distance was getting closer.
The turn around for Mo Zhang came when she joined Froschberg Linz, the Austrian powerhouse of women's table tennis. She joined the club ranked 113 and is now ranked 21. Good coaching, good training partners and the geographical proximity to high level competition allowed the Canadian to develop her talent and to join the ranks of the best women table tennis players world wide
"I want more for 2020," Mo Zhang says, "I want to see how far I can go."
To find out, the Canadian will join an elite training group near Copenhagen, Denmark, with top notch coaching staff and training partners.
Alicia Coté, Canada's #2 - also at Froschberg Linz - has seen a similar improvement during the last 2 years. The 19-year old from Drummondville, QC joined the Froschberg club in 2016 - ranked 498 - and has climbed to the 211th spot in a short period of two years.
Mo Zhang (CAN) - photo courtesy of ITTF


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package com.facebook.buck.core.model.platform;

import com.facebook.buck.core.exceptions.DependencyStack;
import com.facebook.buck.core.exceptions.HumanReadableException;
import com.facebook.buck.core.model.BuildTarget;
import com.google.common.collect.HashMultimap;
import com.google.common.collect.ImmutableList;
import com.google.common.collect.ImmutableSet;
import java.util.Collection;
import java.util.Comparator;
import java.util.Map;

/** Utilities to work with {@link AbstractConstraintValue} */
public class ConstraintValueUtil {

  private ConstraintValueUtil() {}

  /**
   * Buck does not allow duplicate {@code config_setting} in a set of {@code constraint_value} in
   * {@code config_setting} or {@code platform} rules.
   */
  public static void validateUniqueConstraintSettings(
      String ruleType,
      BuildTarget buildTarget,
      DependencyStack dependencyStack,
      ImmutableSet<ConstraintValue> constraintValues) {
    HashMultimap<ConstraintSetting, ConstraintValue> valuesBySetting = HashMultimap.create();

    for (ConstraintValue constraintValue : constraintValues) {
      valuesBySetting.put(constraintValue.getConstraintSetting(), constraintValue);
    }

    for (Map.Entry<ConstraintSetting, Collection<ConstraintValue>> e :
        valuesBySetting.asMap().entrySet()) {
      ConstraintSetting constraintSetting = e.getKey();
      Collection<ConstraintValue> constraintValuesForSetting = e.getValue();
      if (constraintValuesForSetting.size() > 1) {
        throw new HumanReadableException(
            dependencyStack,
            "in %s rule %s: Duplicate constraint values detected: constraint_setting %s has %s",
            ruleType,
            buildTarget,
            constraintSetting.getBuildTarget(),
            constraintValuesForSetting.stream()
                .map(ConstraintValue::getBuildTarget)
                .sorted(Comparator.comparing(BuildTarget::toString))
                .collect(ImmutableList.toImmutableList()));
      }
    }
  }
}

redpajama_set_name: RedPajamaGithub


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Puerto Rico Report
View pages:
Home News Archives
Posts Categorized: War Heroes
Puerto Rico Veterans to U.S. Officials: We Fought for Democracy Abroad; We Want it at Home
Some 10 members of the Puerto Rico Pro-Statehood Veterans Commission, a group of Puerto Rican veterans, are visiting congressional offices this week to deliver a simple message: They defended democracy for the United States abroad and now they want it at home. Because the Commonwealth of Puerto Rico is a territory and not a State,… Read more »
Admiral Horacio Rivero: Puerto Rico's First Navy Admiral
Horacio Rivero was born in 1910 in Ponce, Puerto Rico, just six years before the people of Puerto Rico accepted U.S. citizenship. He graduated third in his class from the US Naval Academy in Annapolis, Maryland, and served in a number of positions, including that of Gunner on the U.S.S San Juan, which was named… Read more »
Early Puerto Rican Military Leadership: Teófilo Marxuach and WWI
The first military unit in the U.S. territory of Puerto Rico was established on March 2, 1899, less than a year after the July 25, 1898, incursion of U.S. forces into Puerto Rico as Spain ceded the island to the United States under the Treaty of Paris. That first military unit was the Puerto Rico Regiment… Read more »
Carmen Garcia Rosado: Soldier and Activist
Carmen Garcia Rosado was one of the first women to join the Women's Army Corps (WAC) in World War II. She was a member of the Puerto Rican WAC unit, Company 6, 2nd Battalion, 21st Regiment of the Women's Army Auxiliary Corps. Rosado, an educator, wrote LAS WACS-Participacion de la Mujer Boricua en la Segunda… Read more »
Language, Culture and Military Training
Members of the Illinois National Guard Special Forces Unit and the Puerto Rico National Guard trained together at Camp Santiago in Salinas, Puerto Rico earlier this month. The training focused on military operations in urban settings, marksmanship, and close quarters combat, but both sides reported that they also benefited in another way. The trainings were… Read more »
A Page from History: Lt. Augusto Rodriguez, Puerto Rico's Civil War Soldier
Puerto Rico has provided military men and women for the United States since 20,000 newly created U.S. citizens were drafted from Puerto Rico in 1917 to fight in WWI. It is not as well known that there were Puerto Rican soldiers in the American Civil War. In the 1800s, many Puerto Ricans lived in Connecticut,… Read more »
A Personal Story for Puerto Rican Veterans
One of the striking things about Puerto Rico is the high level of military service in the U.S. territory. Particularly when in light of the fact that residents of Puerto Rico cannot take part in presidential elections, it is noteworthy that so many Puerto Ricans have volunteered to serve in their Commander in Chief. One Puerto… Read more »
Medal of Honor Awards to Puerto Rican Soldiers
Next month, President Barack Obama will award 24 U.S.. Army veterans the Medal of Honor for conspicuous gallantry during major combat operations in World War II, the Korean War and the Vietnam War. In each case, the soldiers have previously received the Distinguished Service Cross, which is the nation's second highest military award. The Medal… Read more »
Pierluisi Honors Puerto Rico's Military
Rep. Pedro Pierluisi honored the military men and women of Puerto Rico in a speech on the floor of the House of Representatives on Wednesday. Pierluisi reminded his fellow representatives that Puerto Ricans have served in the military in disproportionate numbers in every conflict since World War I. Speaking of the portraits of fallen soldiers… Read more »
Honor the Borinqueneers
On Veterans Day, we think more than ever of the Borinqueneers, members of an all-volunteer regiment of Puerto Rican soldiers who served with distinction in the U.S. Armed Services since World War I and are known for their extraordinary service and valor during the Korean War. Many groups are now working to gain recognition for the Borinqueneers… Read more »
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I registered to the first edition of the EQT 10 Miler being held in Pittsburgh in 2013 (Sunday, November 3). The registration fees were $40, which is honest/moderate for such a distance. Some will argue that this is on the expensive side for a first edition, but, considering the race and the quality of the organization, this is really worth it.
The race go around the South and North side of Pittsburgh. We started at Station Square and go in the North Side, crossed several bridges and go on Penn and Liberty avenues (two main avenue in the city). The road was clear with plenty of space. There was aid station and water stop. Several pacers were here in case you want to maintain a specific pace and they also give an estimate arrival time. The finish is at the EQT building in downtown.
The organization of the event was just great. The packet pick up was quick, simple and efficient. In less than 5 minutes, everything was done. The starting line was not too packed and it was pretty easy to pass the slowest runner and get your own pace. The course itself was really nice, crossing the bridges and passing by the North Side area is something you will enjoy, especially because many runners (at least the one I know) are not used to this area. The finish line was also well organized, with plenty of food and water.
The packet contains a nice tech shirt and you get a medal once you cross the finish line. Many race at that price does not provide such a package, most of them have regular shirt you do not use for training.
There was a pasta dinner organized but few people attended. As a volunteer, I was invited and the location (the Gateway Clipper) was really great, offering a nice view of Pittsburgh. The food option was basic (pasta, yogurt and cookies) but accurate for people racing within few hours. Unfortunately, few people came to the dinner. It would have been better to get more runners on the boat and make a tour. Maybe the dinner should be announced before and more explicit to try to get more people on board.
The only thing I did not really understand was the number of elite athlete invited to the race. Although it is obvious that having well-known athletes brings some challenge, some reported that there was so many of them that it was almost impossible to get a prize. This is not clear if having such athletes is really important for other runners and finally, it does not matter or impact the quality of this race: the overall feedback among the runner community is very good and this is what really matters. And this is probably because I have no interest in professional runners: even if I respect work and performance of professional athletes, I do not read famous journal (such as Runners Worls) and have no real interest on that topic. So, probably not my thing and might interest other folks.
Organization: water stop, aid station, etc.
Pasta Dinner: trying to get more runners and make a tour around the city !
Sure ! If you live in Pittsburgh, there is no reason for skipping it. If you do not live in Pittsburgh, this is a good opportunity to try a new race among this great city. Considering the organization, the package and the overall experience, this is a well-priced race you will enjoy for sure. So, let's do it again !


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Port Carlisle railway station was a railway station in Port Carlisle, Cumbria; the terminus on the Port Carlisle Railway, serving the village and old port and the steamer service to Liverpool that ran from here until 1856, when it was transferred to Silloth. Port Carlisle was two and a half miles away by train from Drumburgh and Glasson was one and a quarter miles away. The journey time to Drumburgh was nine minutes, although Glasson was a request stop.

History
A port was built in 1819 at the hamlet of Fisher's Cross, later renamed Port Carlisle, and four years later, in 1821, the eleven and a half mile-long Carlisle Navigation Canal was built to take goods to Carlisle. The canal was closed in 1853 and the canal basin at Carlisle and parts of the canal were filled in by the Port Carlisle Railway Company, who constructed a railway that started passenger services commenced in 1854, discontinuing them two years later when the Carlisle & Silloth Bay Railway & Dock Company's (C&SBRDC) new railway to Silloth opened, utilising the Port Carlisle Branch as far as Drumburgh. A brief resurgence of business at Port Carlisle had taken place upon the opening of the railway, taken away however by the new port at Silloth and the transfer of the steamer service to Liverpool.

As a cheap alternative a horse-drawn service was provided in 1856 between Drumburgh and Port Carlisle for a number of years. In 1914 steam power was used and to try to avoid closure, a steam railmotor called 'Flower of Yarrow' was built and this service to Port Carlisle railway station lasted until the branch was closed in 1932. Freight services had been withdrawn in 1899.

By altering sediment-carrying currents the construction of Solway railway viaduct of the Solway Junction Railway caused Port Carlisle harbour to silt up and lose trade, which in turn eventually resulted in the abandonment of the Port Carlisle to Carlisle railway. The large Ravenbank Jetty further up the Solway had also thrown the River Eden off towards the Scottish side and further hindered access to the port.

The Port Carlisle Railway Company had agreed to supply a locomotive if the C&SBRDC provided rolling stock. The North British Railway leased the line from 1862, it was absorbed by them in 1880, and then taken over by the London and North Eastern Railway in 1923.

On the day of closure residents gathered in a bower on the bowling green and passed a motion that "the line had been closed because of the poor and inadequate service offered to the public."

Infrastructure
The station had a substantial station house and a single platform intersected by a road crossing. A spur with sidings ran down towards the old canal jetty basin, a longer siding ran down to a second jetty and a turntable was located near the tumulus.

At Canal Junction the Port Carlisle line made an end on junction with the earlier goods branch from London Road and it was this section on to Drumburgh (pronounced drum-bruff) that was taken over by the Carlisle & Silloth Bay Railway & Dock Company. Immediately west of Drumburgh station the line branched off from the line to Silloth, passing under a minor road to Port Carlisle. The branch ran close to the south bank of the Solway Firth and the course of Hadrians Wall heading over low ground to the terminus of the line at Port Carlisle.

Micro-history
The Brampton to Brampton Junction line was also worked by a horse-drawn carriage from circa 1838 to 1881 and was known as the 'dandy' line.

Until the 1980s the station platform was fully intact and open to view; it has since been infilled and is part of a car park.

The railway leading to Port Carlisle lay close to the course of Hadrians Wall for much of its course.

Four horse-drawn 'Dandy cars' built by the North British Railway. The Dandy car was originally preserved at Carlisle, before being moved to the National Railway Museum at York. Port Carlisle became a day tourist attraction to Carlisle Victorians. Isaac Hickson was the driver of the horse-drawn train, and he became the guard on the steam powered train that entered service on 6 April 1914.

The 'Flower of Yarrow' Sentinel Railcar used on the line was driven by James Grey with T. Jackson as the fireman worked on the Port Carlisle Railway in 1932, before its final closure.

References
Notes

Sources

External links
 1866 6" OS map of the station National Library of Scotland
 Edwardian 6" OS map of the station National Library of Scotland
 The branch from Drumburgh with mileages Railway Codes
 The station and line Rail Map Online
 1840 Admiralty chart showing Port Carlisle and the canal National Library of Scotland

Disused railway stations in Cumbria
Former North British Railway stations
Railway stations in Great Britain opened in 1854
Railway stations in Great Britain closed in 1917
Railway stations in Great Britain opened in 1919
Railway stations in Great Britain closed in 1932

redpajama_set_name: RedPajamaWikipedia


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After Over 100 Plastic Surgeries, Model Suffers The Consequences (Photos)
Gee, another woman who turns herself into a freak in pursuit of the perfect body. It's just sad and horrific. I don't even know where to begin with this woman. I'm sure at one time, she was beautiful. Now, she's nightmarish. She's had over 100 plastic surgeries to get this look. What kind of doctor does this? Ethics anyone? And it's even worse than that, an unusually large-breasted and wide-hipped Instagram model nicknamed the "human blow up doll" died at the ripe old age of 23 because of this insanity. What a freaking waste.
Kristyna Martelli was known on social media for her extreme body decisions. "[RIP] beautiful I still can't believe it," tweeted Amy Anderssen, a friend of Martelli's. Uh huh… and it never occurred to her friend that Kristyna had mental issues? Not much of a friend if you ask me. "Yesterday, the most beautiful and amazing woman in the world passed away," Martelli's Facebook page read about the model, who has over 600,000 Instagram followers. "We will always love you. You are gone but not forgotten. REST IN BEACH KRISTYNA MARTELLI." Over 600,000 people thought this was just fine and sane. That's sick.
She first went under the knife at the tender age of 17. Rumors on the web abound that the extreme surgeries caused her death. That would not surprise me in the least. It could have been an infection or a rejection. Whatever it was, she courted her own death. "[Martelli] passed away a few days ago while having a procedure done," reads The Industry On Blast's Instagram page. "During surgery she had a seizure and died." I wouldn't be at all surprised by that either.
This has caused an uproar as sane and normal people are decrying the obsessive plastic surgery habits of some of these people. It's enhancement Russian roulette if you ask me. "There should be a law against this when ppl have … plastic surgery more than 10 times!" a Facebook user wrote on Ent! Breaking News' page. "Smh why, why, RIP." I couldn't agree more. And the doctor who aided this woman in her obsession should be prosecuted and lose his/her license.
This girl definitely had mental issues. Any doctor worth their salt would have seen that and would have turned her down flat. The sad thing is Kristyna didn't believe she had an obsession or mental problems. "The reason of all my surgeries is simply because I wanted to bring my body looks to another level and I regret nothing about any of them," she wrote on her website. "I was never unhappy with what I looked like, I was just simply amazed by all these girls with these plastic looks and went and bought myself anything I needed to look like them!"
"I developed a passion to enhance my body to become the definition of plastic's perfection," she added. "I just absolutely fell in love with it, it's not just a passion, it actually became my hobby, my life." Yep, she was not right in the head and enhanced herself to death. There's more than one way to commit suicide and she chose hers unwittingly.


Beautiful, hand crafted Canadian jewelry following the ancient tradition of wearing jewelry for healing, protection, inspiration and transformational purposes. Stay and explore... there are hundreds of designs for you to fall in love with. We also create custom designs, working alongside you to craft the perfect piece.


Translation:We know what you have been doing there!
I think that's the nature of learning a new language. I constantly have that problem of not recognizing words as they are spoken, even when I know all the words. Keep practicing... :-) But, yes, the text-to-speech can also be poor or even a bit wrong at times.
"Co jest tam na dole?"


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Q: Unable to edit WFS layers in QGIS I am unable to edit WFS layers in QGIS. I have set up a service access rule in Geoserver to allow users associated with role "staff_edit" to edit WFS layers. I followed this tutorial to ensure that I did not miss a critical step. I am currently using QGIS 2.16 and Geoserver 2.9.0.
I have the following service rule in place:
wfs.*   GROUP_ADMIN,ADMIN,staff_edit

No other rules have been specified (yet). I am able to connect to the server and add WFS and WMS layers in QGIS, but I am unable to edit WFS layers. The following have been verified:

*

*WFS service level set to "Complete"

*"staff_edit" role given WRITE access mode

*The data come from a PostGIS data store and credentials grant editing privileges (currently using admin credentials).

*tried uploading a vector dataset that was not in PostGIS, and same inability to edit.

How can I allow a specified role to edit WFS layers in QGIS?
UPDATE: The problem only exists on QGIS 2.16.3. Editing works on QGIS 2.14.

A: I had the same problem, and "solved" it by choosing wfs version 1.0.0 in QGIS.
It (1.0.0) seems to not be the default WFS version in QGIS 2.16 but it is in older versions.

redpajama_set_name: RedPajamaStackExchange


It's been a while since we've checked in on Acid Elephant, but in the years since their last studio album, Star Collider, they've continued outputting live material at a fairly steady rate. Solar Caravan is the latest recording to capture the group in their live setting, and over the course of its three tracks, they show that they've been hard at work growing their heavy psych power. Massive riffs, rumbling bass, crashing drums, tight grooves, and enough distortion to make your head swim; they've got them all, with the grit and grime to tar your speakers into suitable earthiness. While all the songs are great, the show-stealer is undoubtedly "Radien", a ~22-minute burner that smokes its way through a few dozen turns in structure, developing a sinister but still psychedelic haze of resonance and tone. As one big EP, it's a fun trip, and Acid Elephant's continued workshopping of their material should keep fans eager for the next full studio effort to arrive.


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FeaturesInterviews
Interview: Theo Kottis
Theo Kottis is one of the UK's most promising next generation artists and DJs.
Since first gaining recognition as a resident of Edinburgh's FLY Club and Glasgow's Sub Club, he can since count the likes of Joris Voorn and Kerri Chandler as fans. With tracks signed to imprints like Get Physical, Moda Black, and Last Night on Earth, Theo has built up an impeccable discography, enjoying regular features from the likes of Pete Tong, B-Traits, Monki, and Danny Howard on Radio 1.
June 2018 proves a big month in the career of Theo Kottis with both his artist album "Beautiful Strangers" and the 11th instalment of Global Underground's renowned NuBreed series. With all this going on, and in the middle of a typically busy season schedule, we caught up with Theo to see how things have changed, stayed the same, and what the future holds.
"I believe my strongest skill is being able to adapt"
Theo, great to chat with you, where are you right now and what you been up to this month?
I'm currently in London, though it's been a busy start to the summer festival season, so I've had gigs all over. I've also been getting stuck in to some promo work with press and radio, as my album is coming out very soon.
What's the basis and concept for the album, even the name 'Beautiful Strangers' feels like it has a deeper meaning behind it?
As a DJ, I believe my strongest skill is being able to adapt, I'm always experimental with my sets but hadn't been quite so much with my producing – until now. With this album, you can hear a range of styles; a true representation of my DJ selection. It's easy to get side-tracked by what you think people expect from you, artistically – so in many ways the Beautiful Strangers concept was a way for me to reset and give myself a whole new headspace, whereby I could make whatever I want, without worrying about it fitting any expectations.
Do you think the album stays true to one specific genre or sound? Or did you aim to explore a wide musical soundscape?
As I said, I've been much more exploratory, you can hear a range of styles in the album. It's the first time that I got experimental with sampling, spending hours finding weird, obscure samples to form the basis of my tracks. I really fell in love with this process. You can hear broken beats, soulful jazz, Brazilian vocals and tribalistic chants all with dance floor appeal.
Any personal favourites from the album?
Right now it's "Acid Disco", as I've had such a buzz seeing it so well received by crowds – it's undeniably a track in the summer festival spirit.
Who was involved with the design and the artwork, do you feel like it turned out how you had envisioned it?
I created the type, it was initially inspired by the distinctive visuals of Tom Ford's film 'Nocturnal Animals', combined with a vision of Sub Club's infamous red lighting. The main design was by Joe Mortell, an amazing artist based in London. It is exactly like what I had envisioned!
Is the label purely going to act as a platform for the album, or will we expect future projects to be released on the label, collaborations too maybe?
Beautiful Strangers is the first in a trilogy of albums, so expect much more – plus some collaborations too. I'm using the label as a way to experiment and not be tied down to a specific sound and hopefully, I'll see myself improve over the next 3 releases.
Have you been or played in Amsterdam before, if so, what do you like most about the city?
I played in Amsterdam a few years ago, I would love to play there again soon. I recently played with Job Jobse and he seemed so passionate about De School, I need to party there! The clubbing and music scene in Amsterdam seems like it's in a really great place right now, very inspiring.
So you'll also be curating your first Beautiful Strangers lineup in your hometown, Edinburgh, in partnership with FLY Open Air. It seems like quite a defining moment, cutting your teeth as FLY's original resident, how has your affinity with FLY over the years influenced your career as a DJ?
I am so excited to reveal the lineup, doing it my hometown gives it that extra special feeling too. Being able to play all night long at Fly has definitely helped me become a better DJ. It gave me a better understanding of the art of warming up and reading the dancefloor. A Fly party is always a belter of a crowd so I can't wait to play for them.
Looks live you've got such a busy summer ahead. You've recently asked to create a compilation mix for the seminal Global Underground series, 'Nubreed'. How do you feel about being part of such an esteemed compilation series? Briefly run us through you track selection process too…
I'm really proud to be involved, to have a physical product on such a legendary series is really special. No matter what happens in my career I'll always have this to look back on. All the tracks chosen have played a part in my journey as a DJ in the last 2 years. With each track, I can recall a specific memory where I've played or danced to it. I could have approached the mix by trying to select the newest music but I felt the best representation of myself is to look back into my music collection.
I believe you've recently moved down to London, how's it been? Any aspects of Scottish life that you really miss?
I am absolutely loving it, I'm in my element! Lots of great networking, record shopping and there's amazing parties on nearly every day. Also the food choice is turning me into some sort of foodie.
I'm missing my crew from Edinburgh but they are all coming down for a visit soon, the party won't stop!
Theo's debut LP Beautiful Strangers is out now, grab it here
Soundcloud Artist Page
Beautiful StrangersFLY ClubGet PhysicalLast Night on Earthmoda blackNuBreedscotlandSub ClubTheo Kottis
Premiere: Speaking Minds & Amarcord – Mermaid's Chant (Rave Mix)
Party Report: FLY Open Air
Mix #219 By Kate Simko
Premiere: Djuma Soundsystem & Westerby – Disambigua (Original Mix)
Free Your Mind Podcast #002 By M.A.N.D.Y.


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Marlins Analysis
Did We Overestimate the Miami Marlins Offense?
By Michael Jong Jun 18, 2012, 10:42am EDT
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June 17, 2012; St. Petersburg, FL, USA; Miami Marlins third baseman Hanley Ramirez (2) strikes out in the sixth inning against the Tampa Bay Rays at Tropicana Field. The Rays won 3-0. Mandatory Credit: Kim Klement-US PRESSWIRE
After a 3-0 defeat at the hands of the Tampa Bay Rays, the Marlins once again suffered a series loss and were left questioning where they will go from here. One thing that has plagued the Fish this month is their offense. The Marlins were shut out and had just two hits last night, and two evenings before they were shut out by the Rays as well with only one hit to their name. For the month, no team has hit worse than the Marlins' .204/.272/.336 (.267 wOBA), and this is not necessarily an isolated situation. Yes, the Fish were hot in the month of May, but they were still 14th in the league in wOBA that month after a month of April during which they also struggled at the plate.
But this was not supposed to be the case. Before the season, the Marlins were projected to be pretty good on offense. Baseball Prospectus's PECOTA projected a .265 TAv that would have put them third in the National League. Even in May, the club was only tied for sixth in the National League in hitting after park adjustment. Overall, the Marlins are only better than the lowly Pittsburgh Pirates and Chicago Cubs with the bats thus far. When combined with the team's poor defense overall, the Fish are currently second to last in the NL in FanGraphs Wins Above Replacement for their position players.
With the team's bats faltering now for one and a half of the two and a half months of the season, the question becomes whether we overestimated the Marlins before the season began.
The Tally
Here are the eight position players whom the Marlins played in their Opening Day lineup and how they have fared so far this season versus their preseason ZiPS projections.
Preseason ZiPS wOBA
2012 wOBA
John Buck .306 .262
Gaby Sanchez .345 .228
Omar Infante .310 .329
Hanley Ramirez .360 .340
Jose Reyes .362 .329
Logan Morrison .354 .298
Emilio Bonifacio .305 .328
Giancarlo Stanton .385 .372
All the players in red are guys that underperformed their projection by more than 20 points of wOBA. The lone player in green, Emilio Bonifacio, is the only guy who outperformed his projection by that much. Omar Infante, who has regressed since his hot April, is the only other starter who has outperformed his projection.
It is very clear that almost all of the Marlins have struggled at the plate, but not all Marlins have been "deservedly" bad. That is, for many of these guys, we can expect regression, and we suspect their true talents have not changed by that much. Jose Reyes and Hanley Ramirez have each lost about 10 points from their preseason projection, and both players have had good stretches that show that they need only see it through to the end of the season to see regression work in their favor. John Buck, as we noted last week, has improved his approach and is getting some pretty bad luck. The same could be said for Logan Morrison, though his situation is more of a mixed bag at this stage. Of the players in the Marlins starting five, only Gaby Sanchez has seen a tremendous fall in performance with a plausible explanation that does not involve large amounts of bad luck.
It should not surprise anyone, then, to see Sanchez be the player with the biggest drop in projected wOBA now versus from the preseason.
Preseason ZiPS
ZiPS ROS Proj
I arbitrarily chose to highlight anyone who lost more than 10 points on their projection from the start of the season. Immediately you can see that Ramirez and Reyes should be fine, and that the three concerns should lie on Buck, Morrison, and Sanchez. Of those three, I would be more concerned about Sanchez and Morrison. Morrison has not put together a good extended stretch of baseball the entire season, and the results of his swings have vacillated from power-heavy and light on contact (June) and patient but weak and lacking in hits (May). Sanchez, on the other hand, has continued to pop the ball up, and his strikeouts are at an all-time high while his walks are down to a career low. His struggles at the plate look very real at the moment, and if anyone was in need of some coaching assistance, it would be him.
Bench Concerns?
When three of your starters have real concerns at the plate, you may already be doing poorly. But the Marlins have compounded this by granting poor backups significant playing time and getting burned with their results. The Fish have given non-Opening Day starters 539 PA and received a .234/.299/.344 (.279 wOBA) out of those guys. Yes, some of them have stepped up, particularly Austin Kearns (.317/.379/.533), Justin Ruggiano (.310/.394/.690), and Donovan Solano (.367/.429/.433), but eventually those players too are sure to regress and bring that bench wOBA down.
However, compared to the other benches in the NL East, for example, we have done at least an adequate job.
Bench PA
Bench wOBA
Atlanta Braves 516 .262
Miami Marlins 539 .279
New York Mets 780 .292
Philadelphia Phillies 539 .322
Washington Nationals (non-Harper) 743 .275
The Phillies and Mets have gotten strong bench production, while the Marlins have outperformed the Braves and Nationals (without Bryce Harper because, let's be honest, he could have started this season and done this well). The Marlins have been able to avoid injury and utilize their bench significantly less than the Mets and Nationals. So despite our frustrations with the Marlins' bench underperforming, the Marlins seem to have been in at least an average situation compared to their division.
Can It Be Fixed?
The team is obviously struggling as a whole, but as we pointed out, only a few players are of real concern. Overall, however, it is likely that we overestimated this team's offense, as evidenced by the dropping projections for each player. The two players to keep an eye on for the rest of the year are clearly Logan Morrison and Gaby Sanchez, both of whom have significantly underperformed their projections.
Still, it was impossible to predict that going into this season. Gaby Sanchez had been a metronome of consistency in terms of end-of-season production at the plate in his first two years. Morrison was a concern heading into this year, if only because we were not sure whether we would get power or batting average Morrison. This season, we have not gotten either.
But while the rest of the team has underperformed, they have not changed so significantly that we should be overly concerned. Going into the season, maybe this team's offense was not the third best in the National League, but it certainly is not the third worst. Everyone else should either stay the course or be on the way up going forward.
Offishial news, 1/19/22: Baseball America Top 100 update; ZiPS projections The latest Miami Marlins coverage to get you through the lockout blues.
Biggest Marlins risers, fallers in ZiPS projections from 2021 to 2022 Which Miami players does the projection system feel significantly better or worse about compared to one year ago?
Offishial news, 1/20/22: Prospect coverage ramps up; player workouts The latest Miami Marlins coverage to get you through the lockout blues.
Offishial news, 1/17/22: All-Time Marlins Draft; 2022 uniform rotation; Aníbal ain't done yet? The latest Miami Marlins coverage to get you through the lockout blues.


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ABB swings to Q4 earns, lowers '05 earns margin
Published: Feb. 17, 2005 at 2:44 a.m. ET
Kabir Chibber
LONDON (MarketWatch) -- Swiss-Swedish engineering group ABB ABB, -0.32% ABB, -0.39% said it swung to a net income of $13 million in the fourth quarter, but was "burdened by costs to exit businesses in discontinued operations." Last year, its net loss was $391 million. Earnings before interest and tax more than doubled to $264 million, fuelled by double-digit revenue growth in its core divisions, Power Technologies and Automation Technologies. This beat broker expectations of $216.3 million, according to AFX News. Revenue rose 11 percent to $5.97 billion and orders rose 10 percent to $5.2 billion. ABB lowered its 2005 EBIT margin target to 7.7 percent from 8 percent previously, reflecting reclassification of its oil, gas and petrochemicals business into continuing operations from discontinued operations in accordance with U.S. GAAP accounting requirements. ABB also said it remains ubable to predict the financial impact of any asbestos liability. It recommended no dividend be paid in 2004, as in 2003.


The laws governing the practice of engineering and land surveying can be found in Iowa Code, Section 542B. The following information is provided merely as an overview of some of the more often referred to areas of the Code.
Following are a few of the terms referenced in 542B that practicing engineers and land surveyors, as well as others, should be knowledgeable of.
Engineering documents: The term engineering documents as used in 542B includes all plans, specifications, drawings and reports, if the preparation of such documents constitutes or requires the practice of engineering.
Engineer intern: The term engineer intern as used in 542B means a person who passes an examination in the fundamental engineering subjects, but does not entitle the person to claim to be a professional engineer.
In responsible charge: The term in responsible charge means having direct control of and personal supervision over any land surveying work or work involving the practice of engineering. One or more persons, jointly or severally, may be in responsible charge.
• Industrial or consumer products or equipment of a mechanical, electrical, hydraulic, pneumatic, or thermal nature insofar as they involve safeguarding life, health, or property, and including such other professional services as may be necessary to the planning, progress, and completion of the services further identified in this Code section.
• Design coordination includes the review and coordination of technical submissions prepared by others, including as appropriate and without l limitation, consulting engineers, architects, landscape architects, land surveyors, and other professionals working under the direction of the engineer.
• Engineering surveys include all survey activities required to support the sound conception, planning, design, construction, maintenance, and operation of engineered projects, but excludes the surveying of real property for the establishment of land boundaries, rights of way, easements, and the dependent or independent surveys or re-surveys of the public land survey system.
A. Practices any branch of the profession of engineering.
B. Makes a representation by verbal claim, sign, advertisement, letterhead, card, or other manner that the person is a professional engineer.
C. Uses any title which implies that the person is a professional engineer, or that the person is certified under this Chapter.
D. The person holds the persons self out as able to perform, or who does perform, any service or work included in the practice of engineering.
B. 2. Uses or employs the words Professional Engineer or Land Surveyor, or implies authorization to provide or offer professional engineering or land surveying services, or otherwise uses or advertises any title, word, figure, sign, card, advertisement, or other symbol or description intending to convey that the person is a professional engineer or land surveyor, or is engaged in the practice of engineering or land surveying.
The Board has the power to assess civil penalties in a number of other areas such as falsely impersonating any Licensed Professional Engineer, and aiding or abetting an unlicensed person who engages in any activity identified in the Code.
So, in other words, not only might the civil penalty be assessed against the individual found to practicing without a license, but it could also be assessed against that individuals client if they hired an person to do engineering or land surveying services knowing that that individual was not an Engineer or Land Surveyor (for additional information see 542B.27).
Professional engineer: The term professional engineer as used in the Code means a person, who by reason of the persons knowledge of mathematics, the physical sciences, and the principles of engineering, acquired by professional education or practical experience, is qualified to engage in the practice of engineering.
So am I a Licensed Professional Engineer, or a Registered Professional Engineer?
Prior to 1996 engineers in Iowa were referred to as Registered Professional Engineers. In 1996 the law was changed to refer to Professional Engineers as Licensed Professional Engineers.
Likewise, the term Engineer in Training was changed to Engineer Intern at that same time.
What if someone is practicing engineering but they are not a licensed professional engineer?
In 1996 the engineering law was expanded to give the State Licensing Board to assess civil penalties against unlicensed individuals found to be practicing or offering to practice professional engineer or land surveying services (see the definition of the practice of engineering).


Africa Beverage Forecasts is a bi-annual report designed as a global manual to provide both historical consumption trends for all commercial beverage categories, and forecast trends five years into the future. It is mainly numbers based, but includes a short analysis exploring the trends behind the data and forecast assumptions for each beverage category.
• Insightful and valuable analysis of the drivers behind the beverage trends and forecast assumptions for Nigeria and South Africa.
• Soft Drinks: Packaged Water (excludes all water sold in large containers of >10 liters), Carbonates, Enhanced Water, Flavored Water, Juice (100% pure juice), Nectars (products with a 25-99% juice content), Still Drinks (<25% juice content), Squash/Syrups, Fruit Powders, Iced/Ready To Drink (RTD) Tea Drinks, Iced/Ready To Drink (RTD) Coffee Drinks, Sports Drinks, Energy Drinks.
• Dairy & Soy Drinks & Milk Alternatives: Condensed Milk, Drinking Yogurt, Evaporated Milk, Fermented Milk, Flavored Milk, Grain Nut Rice and Seed Milk Alternative Drinks, Soymilk, White Milk.
• Hot Drinks: Hot Coffee, Hot Tea.
• Evaluate the very latest beverage category forecast projections to 2022 to enhance your understanding of consumption patterns and evolving trends in the beverage industry.
• Identify the current and emerging trends and future growth opportunities in the beverage market to assess the likely impact on your company's performance.
• Interrogate the data to understand both the historic and likely future performance of the beverage industry by country and category to support your long-term strategic planning.


text:
Home News Alleged OnePlus 6T Retail Box Leaks Out on Weibo
Alleged OnePlus 6T Retail Box Leaks Out on Weibo
Last Updated: September 4, 2018 6:33 pm
Chinese smartphone maker OnePlus is expected to launch the OnePlus 6T soon, and while we all expect it to take after the Oppo R17 Pro, details about the phone have so far been far and few in between. Now however, a new leak has popped up on Weibo showing the OnePlus 6T's retail box, and it gives away quite a lot about the phone itself too.
As seen in the image shared on Weibo by VP Technology (a tech blogger from China) the box looks like it'll have the names of various OnePlus Forum members printed on the inside.
Image Courtesy: VP Technology (Weibo)
There's the OnePlus 6T branding on one side, and the words 'Unlock the Speed' on the other. We can also see the box showing a diagram of the OnePlus 6T and it pretty much confirms that the phone will indeed feature a waterdrop notch like the Oppo R17 Pro, and will also come with an in-display fingerprint scanner.
As far as specs are concerned, the phone will likely launch with Snapdragon 845, 6/8GB of RAM, and 64/128/256GB of storage, which would fall in line with OnePlus launching T variants with the same specs as the non-T variant but with improved design. We saw this happen with the OnePlus 5 and 5T, and it looks like the OnePlus 6T will follow the same tradition.
OxygenOS Update for OnePlus 6, 6T Adds OnePlus Buds Support and More
OnePlus 6/6T Get Stable OxygenOS 10 Based on Android 10
OnePlus 6 and 6T Receive Android 10 Update with New Open Beta Build
NotifyBuddy Brings a Notification LED to Your Phone's AMOLED Display
You Can Now Get Android Pie-based MIUI 10 for OnePlus 6, OnePlus 6T


text:
{-# LANGUAGE QuasiQuotes #-}
module Hpack.Syntax.DefaultsSpec (spec) where

import           Helper

import           Data.Aeson.Config.FromValueSpec hiding (spec)

import           Data.Aeson.Config.FromValue
import           Hpack.Syntax.Defaults

defaultsGithub :: String -> String -> String -> [FilePath] -> Defaults
defaultsGithub owner repo ref path = DefaultsGithub $ Github owner repo ref path

spec :: Spec
spec = do
  describe "isValidOwner" $ do
    it "rejects the empty string" $ do
      isValidOwner "" `shouldBe` False

    it "accepts valid owner names" $ do
      isValidOwner "Foo-Bar-23" `shouldBe` True

    it "rejects dots" $ do
      isValidOwner "foo.bar" `shouldBe` False

    it "rejects multiple consecutive hyphens" $ do
      isValidOwner "foo--bar" `shouldBe` False

    it "rejects hyphens at the beginning" $ do
      isValidOwner "-foo" `shouldBe` False

    it "rejects hyphens at the end" $ do
      isValidOwner "foo-" `shouldBe` False

  describe "isValidRepo" $ do
    it "rejects the empty string" $ do
      isValidRepo "" `shouldBe` False

    it "rejects ." $ do
      isValidRepo "." `shouldBe` False

    it "rejects .." $ do
      isValidRepo ".." `shouldBe` False

    it "accepts underscores" $ do
      isValidRepo "foo_bar" `shouldBe` True

    it "accepts dots" $ do
      isValidRepo "foo.bar" `shouldBe` True

    it "accepts hyphens" $ do
      isValidRepo "foo-bar" `shouldBe` True

  describe "fromValue" $ do
    context "when parsing Defaults" $ do
      let
        left :: String -> Result Defaults
        left = Left
      context "with Object" $ do
        it "fails when neither github nor local is present" $ do
          [yaml|
          defaults:
            foo: one
            bar: two
          library: {}
          |] `shouldDecodeTo` left "Error while parsing $ - neither key \"github\" nor key \"local\" present"

        it "accepts Defaults from GitHub" $ do
          [yaml|
          github: sol/hpack
          ref: 0.1.0
          path: defaults.yaml
          |] `shouldDecodeTo_` defaultsGithub "sol" "hpack" "0.1.0" ["defaults.yaml"]

        it "rejects invalid owner names" $ do
          [yaml|
          github: ../hpack
          ref: 0.1.0
          path: defaults.yaml
          |] `shouldDecodeTo` left "Error while parsing $.github - invalid owner name \"..\""

        it "rejects invalid repository names" $ do
          [yaml|
          github: sol/..
          ref: 0.1.0
          path: defaults.yaml
          |] `shouldDecodeTo` left "Error while parsing $.github - invalid repository name \"..\""

        it "rejects invalid Git references" $ do
          [yaml|
          github: sol/hpack
          ref: ../foo/bar
          path: defaults.yaml
          |] `shouldDecodeTo` left "Error while parsing $.ref - invalid Git reference \"../foo/bar\""

        it "rejects \\ in path" $ do
          [yaml|
          github: sol/hpack
          ref: 0.1.0
          path: hpack\defaults.yaml
          |] `shouldDecodeTo` left "Error while parsing $.path - rejecting '\\' in \"hpack\\\\defaults.yaml\", please use '/' to separate path components"

        it "rejects : in path" $ do
          [yaml|
          github: sol/hpack
          ref: 0.1.0
          path: foo:bar.yaml
          |] `shouldDecodeTo` left "Error while parsing $.path - rejecting ':' in \"foo:bar.yaml\""

        it "rejects absolute paths" $ do
          [yaml|
          github: sol/hpack
          ref: 0.1.0
          path: /defaults.yaml
          |] `shouldDecodeTo` left "Error while parsing $.path - rejecting absolute path \"/defaults.yaml\""

        it "rejects .. in path" $ do
          [yaml|
          github: sol/hpack
          ref: 0.1.0
          path: ../../defaults.yaml
          |] `shouldDecodeTo` left "Error while parsing $.path - rejecting \"..\" in \"../../defaults.yaml\""

      context "with String" $ do
        it "accepts Defaults from GitHub" $ do
          [yaml|
          sol/hpack@0.1.0
          |] `shouldDecodeTo_` defaultsGithub "sol" "hpack" "0.1.0" [".hpack", "defaults.yaml"]

        it "rejects invalid owner names" $ do
          [yaml|
          ../hpack@0.1.0
          |] `shouldDecodeTo` left "Error while parsing $ - invalid owner name \"..\""

        it "rejects invalid repository names" $ do
          [yaml|
          sol/..@0.1.0
          |] `shouldDecodeTo` left "Error while parsing $ - invalid repository name \"..\""

        it "rejects invalid Git references" $ do
          [yaml|
          sol/pack@../foo/bar
          |] `shouldDecodeTo` left "Error while parsing $ - invalid Git reference \"../foo/bar\""

        it "rejects missing Git reference" $ do
          [yaml|
          sol/hpack
          |] `shouldDecodeTo` left "Error while parsing $ - missing Git reference for \"sol/hpack\", the expected format is owner/repo@ref"

      context "with neither Object nor String" $ do
        it "fails" $ do
          [yaml|
          10
          |] `shouldDecodeTo` left "Error while parsing $ - expected Object or String, encountered Number"


For more documentation on the command line client, see the synapseclient docs.
The synapseclient package is available to use Python to access Synapse. See the Python client docs for supported versions of Python.
For complete documentation of the Python client, visit the synapseclient docs.
The synapser package is available for R version 3.4 and 3.5.
To connect to Synapse with stored login credentials, visit the synapser Overview page. For more documentation on the R client, see synapser R docs.
Report client-specific issues or bugs at the R client or Python (including the command line client) GitHub Issues pages. If you have questions on how to use the clients to interact with Synapse, please ask in the Synapse Help Forum.


Grinning While Growing: Evan Turned Two!
Wife of Todd, mother of Evan, follower of Jesus, teacher of children, lover of life!
My baby turned two yesterday! How did that happen? I'm sure you can tell by my lack of blogging that he keeps me VERY busy! But, I wouldn't change a thing about him! So, to bring you up to speed, here are a few things about Evan from the last year!
Evan had his first haircut!
Went to Shell Island for the first time!
He blew out his candles all by himself!
So there you have it. Evan's second year in a picutre nutshell. I'd like to say i'll blog more often but, i can make any promises. I forsee Evan's third year to be even more busy!


Welcome to the Tremel family Web page. We are Appalachian oil field historians. Our hobby includes: researching, restoring, and preserving a piece of our oil heritage.
All times are GMT -4. The time now is 01:52:20 AM.


text:
JANUARY 1973 - PHILIPPINE SUPREME COURT DECISIONS
Rafael Zulueta, et al. vs. Pan American World Airways, Inc.
IN RE: IBP
In the Matter of the Integration of the Bar of the Philippines.
Enriquita T. Viray vs. Helen Mariñas, et al.
Conchita Cadano vs. Juan Cadano
People of the Philippines vs. Apolonio Enomar
Guillermo E. Torres vs. Court of Appeals, et al.
American Express Company, Inc. vs. Cirio H. Santiago
Intestate Estate of Julian A. Wolfson. Manuel Y. Macias vs. Ricardo Vito Cruz, et al.
Charito Planas vs. Commission on Elections, et al.
Phil. American Management Company, et al. vs. Philippines American Management Emp. Assoc., et al.
Alfredo Leongson, et al. vs. Court of Appeals, et al.
People of the Philippines vs. George Daeng, et al.
People of the Philippines vs. Romualdo Ricalde
National Marketing Corporation vs. Federation of United Namarco Distributors, Inc.
People of the Philippines, et al. vs. Alfonso P. Donesa, et al.
Soledad Arangco, et al. vs. Gloria Baloso
People of the Philippines vs. Camsa Otto, et al.
Miguel Perez Rubio vs. Herminio Mariano, et al.
Raymundo Z. Familara vs. J.M. Tuason & Co., Inc., et al.
Florenda Ariem vs. Walfrido De Los Angeles
Teodulo E. Abbu vs. Bernardo Teves, et al.
Pedro C. Parojinog, Jr. vs. Geronimo R. Marave, et al.
China Banking Corporation, et al. vs. Wenceslao Ortega, et al.
Republic, et al. vs. Augusto M. Amores, et al.


text:
Q: How can I calculate GCD of really large BigInteger numbers without getting a stackoverflow exception? I implemented my own Class Fraction, where I have a BigInteger numerator object and BigInteger denominator object. Whenever I call the constructor of a Fraction object, it parses the numerator and denominator from the argument and simplifies the fraction. The problem I am having is that I am getting stack overflow exception when calling gcd(biginteger numerator, biginteger denominator) for really big numbers. I want to be able to get the gcd of really big BigInteger objects.
private BigInteger gcd(BigInteger a, BigInteger b)
{
        if(a.mod(b).toString().equals("0"))
            return b;
        return gcd(b, a.mod(b));
}

The error I'm getting is:
Exception in thread "main" java.lang.StackOverflowError
    at java.math.MutableBigInteger.divideKnuth(MutableBigInteger.java:1203)
    at java.math.MutableBigInteger.divideKnuth(MutableBigInteger.java:1163)
    at java.math.BigInteger.remainderKnuth(BigInteger.java:2167)
    at java.math.BigInteger.remainder(BigInteger.java:2155)
    at java.math.BigInteger.mod(BigInteger.java:2460)
    at Fraction.Fraction.gcd(Fraction.java:69)
    at Fraction.Fraction.gcd(Fraction.java:71)
    at Fraction.Fraction.gcd(Fraction.java:71)
    at Fraction.Fraction.gcd(Fraction.java:71)

And A lot more of the Fraction.Fraction.gcd(Fraction.java:71).

A: The problem is that you have coded Euclid's algorithm incorrectly.  The algorithm is this:
gcd(a, 0) = a
gcd(a, b) = gcd(b, a mod b)

That's not what your code does.
// This is supposed to implement the first term ... but it doesn't
if (a.mod(b).toString().equals("0"))
        return b;

The comments above by @clemens and @EJP are apropos.
The comment by @AlexF is only relevant for extremely large numbers.  Euclid's algorithm converges rapidly.  (See https://math2.uncc.edu/~frothe/Euclidextendpnew.pdf for the gory details.)


text:
Liverpool's Lovren optimistic ahead of United, Chelsea clashes
Published On: January 4, 2017 04:20 PM NPT By: Reuters
A draw at Sunderland was not the end of the world for Liverpool as they attempt to chase down Chelsea for the Premier League title with key fixtures in January against Manchester City and the leaders on the horizon, according to defender Dejan Lovren.
The Merseyside club are second on the table, five points behind Chelsea, though they had a golden opportunity to close the gap on Monday but conceded a late equaliser at Sunderland.
"It felt like a defeat, especially after beating Manchester City," Lovren told the Liverpool Echo. "But we have to keep our heads high. A point is better than nothing."
Having already defeated title contenders Chelsea, Arsenal and Manchester City earlier this season, Lovren backs his side's mentality to keep them in the hunt.
"There is still half a season to go. There are so many games in front of us and in front of Chelsea. We just have to concentrate on ourselves," he added.
"We have some really big games in front of us. I'd say we like to play against the big teams. There's a lot to play for."
Liverpool travel to Old Trafford to face sixth-placed United on Jan 15, before hosting Chelsea on Jan 31.
dejan lovren
City stay ahead of United with win over champions Chelsea
LONDON, Oct 1: Manchester City stayed ahead of age-old local rivals Manchester United at the top of the Premier League...
Chelsea beat Mourinho's 10-man United to reach Cup semis
LONDON, March 14: Chelsea manager Antonio Conte got the upper hand on Jose Mourinho for the second time this season as...
Mourinho out for revenge as Man United visit Chelsea in Cup
LONDON, March 9: Jose Mourinho takes his Manchester United side back to former club Chelsea on Monday with a place...


Barrisol's diverse range of colours/finishes, it's ability to be shaped, to incorporate lighting, to provide a quick and lightweight installation, makes Barrisol a perfect option for your projects, from the simple to the complex.
The Quang Ninh Museum in Vietnam includes an "ARTOLIS" printed wall installation.
This installation shows the excellent print quality of the material and also features it's ability to help create the feeling of being in an outdoor landscape while inside an urban setting.
In our experience, we have found that nature photography and art prints are a perfect choice for commercial, industrial, and residential spaces, as they help to create a sense of calm and wonder within a room.
For more information about Barrisol's "ARTOLIS" line of wall fabrics please click here.
Combining Barrisol "Mirror", "Lacquer Finish" and "Artolis" Wall Fabric.
The following project is an excellent example of including multiple Barrisol finishes in one space, maximizing both the acoustics and aesthetics.
Barrisol is the perfect choice for restaurants and bars because of it's acoustic properties, quick dust free installation, and it's diverse range of finishes.
We are often asked if Barrisol is only for commercial applications. The reality is that Barrisol is a fantastic product for both commercial and residential projects. Barrisol's quick, dust free installation, it's ability to incorporate lighting, to create custom shapes/sizes, and to be highly reflective while still being acoustic, makes Barrisol the perfect match for a home renovation.
Barrisol® Clim®: for clean, healthy air and a constant temperature.
Barrisol® Clim® evens out the temperature of both your walls and the air, wherever you are in the room.
The extremely low temperature difference between the head and the feet of an occupant (1.0°C in heating mode and 0.5°C in cooling mode), alongside the almost imperceptible air speed, means that Barrisol® Clim® can provide unparalleled comfort.
Unlike "static" air conditioning ceilings (which use hydraulic tubes), Barrisol® Clim® offers almost unlimited power.
The admissible power of 600W/m2 while heating and 550W/m2 while cooling ensures that it can meet your heating and cooling needs, wherever you are on the planet.
Barrisol's 50th Anniversary book features an awe inspiring array of installations. Simply click on the cover below to view the full pdf version of the book.
This is an excellent example of a create, and aesthetic, use of light.
Location: Brandhorst Museum - Germany.
"The Contemporary Art museum of Munich was inaugurated last May. Its architecture is based on a design and ecological concept. The architect Sauerbruch Hutton chose Barrisol Lumière® to light and enhance the exposed works of the XXth century among which the Andy Wahrol's famous paintings. Indeed, Barrisol Lumière® diffuses the light in a sweet and homogeneous way on the whole exhibition space. Furthermore, the Barrisol sheets are 100%, recyclable and are so perfectly adapted in this modern building turned to sustainable environment." - Courtesy of www.barrisol.ca.
This West Vancouver wine room features the Emily Carr painting Big Raven, printed on the Barrisol's Artolis wall fabric. Thanks to the Vancouver Art Gallery for their work provided the graphic file. We look forward to a continued relationship with the VAG to bring your print projects to fruition. Both the Barrisol stretch ceiling system and the Barrisol Artolis wall fabric can be printed, allowing for custom images, art reproductions and aesthetic diversity.
Special thanks to Danielle Currie, Maegan Hill-Carroll and Rachel Topham from the Vancouver Art Gallery.
Barrisol ceiling installation (matt white) and Barrisol Artolis wall installation (printed Big Raven) completed by Barrisol BC.
Wine room renovation completed by Woodworks Custom Developments.
Design Architect: Terry Doyle, Architerior Design.
Emily Carr art graphic provided by the Vancouver Art Gallery.
Click on the image below to view the Barrisol booklet online.


Armando Fosco Sr. (July 13, 1922 – February 5, 1987) was former Secretary-Treasurer of Local 738 of the International Brotherhood of Teamsters.According to FBI documents, the government believed Armando was a member of the Chicago Outfit. FBI Agents observed Armando working with Outfit heavyweight Ross Prio. His wife, Gloria M. Nappi, was a blood relation to Outfit political fixer Romie J. Nappi.In 2009, Armando's son, Joseph Fosco, named Armando in a first of its kind civil RICO lawsuit against a mafia group. Armando was identified in the lawsuit as a suspected embezzler who failed to make a kickback payment to the Chicago Outfit. According to the complaint, it was alleged that members of the Chicago Outfit, including Outfit boss John DiFronzo, schemed to extort money from the Fosco family, as if the family was in possession of said ill-gotten gains alleged to have been skimmed from the International Brotherhood of Teamsters. The case was ultimately dismissed for statute of limitations issues.
James J. Marcello (born December 13, 1943), also known variously as "Little Jimmy", "Jimmy Light" and as "Jimmy the Man", is an imprisoned crime boss who was a front boss for the Chicago Outfit criminal organization in the 1980s, 1990s and early 2000s. Organized crime observers identified Marcello as a figurehead during that period while the organization's day-to-day operations actually were run by John "No Nose" DiFronzo, Joseph "Joey the Clown" Lombardo, Joseph "Joe the Builder" Andriacchi and Angelo J. LaPietra.
Joseph "the Builder" Andriacchi (born October 20, 1932) is a Chicago area resident and convicted criminal, considered by that city's Crime Commission to be a high-ranking member of the Outfit, the city's LCN organization.
This list includes mobsters and International organized crime figures by area of operation/sphere of influence. Some names may be listed in more than one city.
Marco D'Amico (born January 1, 1936) is a Chicago mobster and a high-ranking member of the Chicago Outfit crime organization. He admitted his role in the Chicago Outfit in federal court in 1995.
Michael Magnafichi is a member of the Chicago Outfit. He is the son of Lee Magnafichi, who also was a member of the Outfit, supposedly working under John "Jackie The Lackey" Cerone. Michael would later become Jackie Cerone's personal driver.
In a declassified 2002 FBI memorandum, Magnafichi was identified as one of the principal threats to the safety of mob turncoat Nick Calabrese, a cooperating witness in the Operation Family Secrets trial.Some sources claim that Michael, along with Rudy Fratto, was or still is an Elmwood Park street boss under Peter DiFronzo, brother of Outfit leader John DiFronzo. However, an in-depth interview of Michael Magnafichi by Outfit historian Joseph Fosco alluded that Michael has not been actively involved with the Outfit for years.Recently Michael, who spent years running book for the Chicago Outfit, began producing a sports podcast.
Peter DiFronzo (May 13, 1933) is the brother of John DiFronzo (reputed to be the leader of the Chicago Outfit) and Joseph DiFronzo. Peter DiFronzo is supposedly a made man, and stands at 5'8 and weighs 185 pounds. In 1965, he was arrested for interstate stolen property and served ten years in prison. He was featured in William F. Roemer Jr's War of the Godfathers: The Bloody Confrontation Between the Chicago and New York Families for Control of Las Vegas in 1990. His wife, Josephine, is part owner of D&P Trucking, located in Chicago, Illinois, though authorities believe it is Peter and his brothers Joe and John that actually run the enterprise. Peter is also supposedly active in some of the Outfit's racketeering schemes.He has a conviction for transporting stolen goods and served time in Leavenworth. His name appeared on a 2002 FBI list as a potential threat to the life of Nick Calabrese, a star witness in Operation Family Secrets under federal protection.
Rudolph C. "Rudy" Fratto (born December 12, 1943) has been identified by federal authorities and several Chicago newspapers as a high-ranking member of the Chicago Outfit crime organization.
Samuel A. Carlisi also known as "Black Sam" and "Sam Wings" (December 15, 1914 – January 2, 1997), was a Chicago gangster who was in the Chicago Outfit criminal organization. Sam Carlisi's brother Roy was a caporegime in the Buffalo crime family, otherwise known as the Magaddino crime family. Roy was close to legendary Buffalo Mafia boss Stefano Magaddino, which gave Sam direct access to various east coast crime families that were aligned with the Buffalo Mafia such as those based in Rochester and Utica, New York and in Northeastern Pennsylvania. Sam was known to use these connections to further his gambling and bookmaking interests, to fence stolen goods and possibly for narcotics operations he was overseeing or involved in. He was a cousin of mobster Al Tornabene.
Carlisi started his criminal career with the Outfit as a driver for mobster Joseph Aiuppa when he was boss of the Cicero, Illinois crew. He is the uncle to Chicago Outfit mobsters Dominick DiMaggio and Nicholas DiMaggio.
When Aiuppa was convicted in 1986 for the skimming of the Las Vegas casinos, Carlisi served as his replacement and as a front man. Carlisi earned his nickname "Wings" because he often flew around the country as a mob courier during the 1970s. When Ferriola became the boss of the Outfit, Carlisi served as his underboss. This followed the murders of Michael and Tony Spilotro, in which Carlisi had supposedly been involved.
After Ferriola was diagnosed with cancer, he assigned the day-to-day supervision of the Outfit to Carlisi. After Ferriola died, Carlisi became the new boss. In March 1996, Carlisi was convicted of mob racketeering, loansharking, and arson in connection with an illegal gambling business in the Chicago area and the West suburbs and was sentenced to 13 years in prison. Convicted with Carlisi were his chauffeur James "Little Jimmy" Marcello, Anthony Zizzo, Anthony Chiaramonti. On January 2, 1997, Carlisi died with fluid in his lungs as he was being force rushed/dragged out of a prison unit to a waiting golf cart. This caused heart attack while in prison.