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Colon: Neoplastic Disease: Metastatic Cancer: Classic CT Patterns of Dissemination
CT scanning is the modality of choice for the staging of most neoplasms. CT scanning can rapidly and efficiently survey the entire body in the search for metastatic disease. Knowledge of common patterns of dissemination of specific neoplasms is vital for accurate detection and staging. Pattern recognition is also important for suggesting the underlying primary tumor in cases of unknown primary, or when multiple sites are involved and the organ of origin is unclear. This essay reviews some of the common, classic patterns of metastatic disease demonstrated at CT evaluation.
Over 50% of patients with newly diagnosed cancer have metastatic disease present at initial diagnosis . Tumors often disseminate in a predictable and reliable fashion, either proliferating at the first site encountered, or bypassing proximal organs in search of a milieu favorable to metastatic growth . Metastatic dissemination results from a complex series of tumor-host interactions, including cellular invasion, vascular intravasation, circulation, tumor arrest, tumor growth, and angiogenesis . Unusual patterns of metastatic spread, not explained from anatomic considerations alone, is the result of organ tropism: the ability of different tumors to exhibit specific and unique attachment factors, probably via specific tumor surface receptors . Tumors can spread in a variety of channels. The most common pathway is contiguous invasion of adjacent structures via infiltration of tissue spaces. The most common pathways for distant spread in the chest and abdomen are the lymphatics, blood vessels, and epithelial and coelomic cavities.
Lymphatics are entered relatively easily by tumor cells, as lymphatic vessels lack a basement membrane . Tumor cells can then embolize to regional lymph nodes before disseminating into the venous system via lymphaticovenous connections . Axillary and internal mammary lymph node involvement by breast cancer is a classic example of lymphatic dissemination. As tumor cells obstruct lymphatic drainage, retrograde lymphatic spread can occur to additional locations such as the liver, skin, and distant lymph nodes. Tumor involvement of the thoracic duct is especially notorious for altering lymph node, often resulting in widespread retrograde dissemination of cancer cells .
Another pathway of tumor spread is vascular invasion, either arterial or venous. Venous invasion is most common, and typically occurs at the sit e of the primary tumor capsule . Metastases are then embolized to drainage organs where cell arrest can occur, typically at the first capillary bed encountered. Classic examples include the lung for systemic venous emboli, the liver for portal venous emboli, and the peripheral body tissues for arterial emboli. Retrograde venous seeding is also possible, most notably in the paravertebral plexus, which because of it's valveless nature can allow unmitigated tumor cell dissemination from the head to the pelvis . Tumors which can spread via this route are able to bypass the portal and pulmonary systems before dissemination. Classic examples are prostate, breast, renal and lung cancers.
Coelomic cavities involved in tumor dissemination include the pleural space of the thoracic cavity and the peritoneal spaces of the abdomen and pelvis. The most commonly involved is the peritoneum, which carries tumor cells in ascitic fluid. The distribution of intraperitoneal metastases often corresponds to predictable flow patterns, the most classic example of which is seen with ovarian cancer . With this tumor, or any tumor demonstrating intraperitoneal spread, the paracolic gutters, cul-de-sac, omentum, and liver surface are common sites of metastases. In the chest, pleural dissemination typically spreads via gravitational forces and is often seen in the lower thoracic cavity .
Pattern of dissemination: lower neck
Common primaries: head and neck, lymphoma, esophagus, stomach Lower cervical adenopathy can result from metastatic tumors of the head and neck, most commonly tumors of the pharynx, oral cavity, and supraglottic larynx . Supraclavicular nodes are also frequently encountered in patients with lung cancer, and represent stage IV disease. Lymphoma is also commonly encountered in the neck. Supraclavicular lymph node metastases can also represent a site of dissemination at some distance from the primary tumor. For example, tumors of the esophagus and stomach can spread via the thoracic duct to drain into the left supraclavicular nodes (the so-called "Virchow's" node). Cervical or supraclavicular lymph node metastases occur more frequently with upper third esophageal carcinomas.
Pattern of dissemination: internal mammary nodes
Internal mammary adenopathy is an important site of occult metastasis in breast cancer. Involvement is often ipsilateral to the primary tumor and represents a site of regional nodal spread, much like the axilla. Lymphoma represents the other common malignancy to selectively target this nodal chain. Involvement is usually the result of contiguous spread from the anterior mediastinal or paratracheal area to the other mediastinal lymph node groups, including the internal mammary chain. Occasionally, isolated internal mammary nodal involvement is seen.
Common primaries : breast, lymphoma
Pattern of dissemination: mediastinum
Common tumors to involve the mediastinum include bronchogenic carcinoma and lymphoma. In general, the larger and more central the primary lung tumor, the higher the prevalence of mediastinal lymph node involvement. One exception is small cell lung cancer, which can present with bulky mediastinal nodes even in the presence of a small or even grossly undetectable lung primary. Lymphoma classically presents as a bulky anterior mediastinal mass, which can be massive. Another relatively common tumor to metastasize to the mediastinum is breast cancer, often in continuity with an internal mammary nodal mass. In practice, almost any tumor can metastasize to the mediastinum. Without a known primary, histologic confirmation is often necessary.
Common primaries :lung, breast, lymphoma
Direct lymphatic connection from the renal lymphatics to the thoracic duct and mediastinum exist, accounting for the classic but uncommon finding of metastatic renal cell cancer to the mediastinal or hilar lymph nodes, especially on the right side.
Pattern of dissemination: lung parenchyma
Pulmonary metastases occur in 30% of all malignancies, usually through hematogenous dissemination. In 10-25% of cases, the lungs are the only site of metastasis. The classic CT appearance is that of multiple well-defined nodules, often seen in continuity with an underlying blood vessel. Lung metastases are typically widespread, although solitary metastases are not at all uncommon, particulary in colon, kidney, breast, testicular, and musculoskeletal primaries. It is often possible to narrow a differential diagnosis based upon the appearance of metastastic lung nodules. Discrete cavitary nodules are most commonly seen with squamous cell primaries, especially a head and neck tumor in men and cervical cancer in women. "Fuzzy" nodules may indicate a hemorrhagic primary such as renal cell carcinoma or choriocarcinoma, or treated lesions. Miliary nodules are characteristic of metastatic thyroid cancer, melanoma, and adenocarcinoma. A reticulated, "beads-on-a string" appearance suggests lymphangitic spread of tumor, especially common in metastatic lung or breast cancer.
Common primaries:Based on appearance
Pattern of dissemination:pleural space
Metastases constitute the most common tumor to involve the pleura. Involvement can be unilateral or bilateral. Metastatic adenocarcinoma is the most frequent cell type to metastasize, with lung and breast cancer most common. Spread is either by direct spread or lymphatic dissemination. Classic findings include small, lenticular masses and pleural thickening. An associated pleural effusion is often demonstrated. Other tumors which can involve the pleural space include invasive thymoma and lymphoma. Invasive thymomas invade the mediastinum and seed the pleural space directly. Spread from thymomas are usually confined to one hemithorax. Both lymphoma and thymoma can present as well-defined, lobulated pleural implants without associated pleural fluid.
Common primaries :adenocarcinoma, thymoma, lymphoma
Pattern of dissemination: liver
The liver is second in frequency to the lungs as the most common site of metastases. The CT appearance of liver metastases is very dependent on lesion vascularity, histology, and the presence or absence of necrosis, hemorrhage, and calcification. Therefore, a tremendous spectrum of appearances are possibly, even with differing foci of the same tumor. In general, most metastases are hypovascular and appear relatively hypoattenuating, and are best appreciated during the portal-venous phase of contrast-enhancement. Such tumors have classically disseminated to the liver via portal venous emboli: colon cancer is by far the most common tumor to do so. Less common are the hypervascular tumors, which appear as hyperattenuating foci against the normal liver and are best appreciated during the arterial phase of contrast enhancement. Classic hypervascular primaries include pancreatic islet cell tumor, carcinoid tumor, and renal cell cancer. Calcification is typically demonstrated in metastases from mucinous tumors such as colon or stomach cancer, or other primary tumors including ovarian, breast, and thyroid cancer. Necrotic metastases are characteristic of metastatic sarcomas, melanoma, and mucinous tumors of the colon or ovary.
Common primaries :Based on appearance
Pattern of dissemination: gastrohepatic ligament /celiac axis
Metastatic esophageal carcinoma can present in nodes from the supraclavicular region to the celiac nodal chains. Tumors located in the distal third of the esophagus most commonly spread to the regional lymph nodes in the gastrohepatic ligament and celiac axis. Adenocarcinoma of the stomach is another common primary to involve this region. Lymphoma is often in the differential diagnosis.
Common primaries:Esophagus, stomach
Pattern of dissemination: pancreas
Metastases to the pancreas are uncommon. When they do occur, most commonly the primary tumor arises from the kidney, lung, breast, or GI tract. Melanoma can also metastasize to the pancreas. Usually, the diagnosis is suggested by the presence of multiple pancreatic masses in a patient with a known primary. When solitary, however, the appearance can be indistinguishable from primary pancreatic carcinoma. Lymphoma can also present with peripancreatic lymphadenopathy that can mimick a pancreatic cancer.
Common primaries: Kidney, lung, melanoma
Pattern of dissemination: spleen
Metastases to the spleen most often result from hematogeneous dissemination. Metastases typically appear as multiple nodules, although solitary masses are not uncommon. The most common primary malignancies to metastasize to the spleen are lung and breast. Melanoma has the highest incidence of involvement on a per primary basis, seen in up to 30% of patients at autopsy . Cystic metastases can occur with breast, ovary, and melanoma primaries. Calcifications are common in patients with a mucinous adenocarcinoma primary, particularly colon and ovary.
Common primaries: adenocarcinoma, ovary, melanoma
Pattern of dissemination: adrenals
Adrenal gland metastases constitute up to 25% of all adrenal tumors. Involvement is commonly by hematogenous dissemination. Metastases can be unilateral or bilateral. Lesions tend to be well circumscribed and of soft-tissue attenuation. Size can vary from small to very large. Lung cancer is the most common primary, with adrenal metastases found in up to 20% of patients . Other relatively common primary sites include the breast, kidney, colon, pancreas, esophagus and thyroid. Of these, kidney and breast cancer are most common. Metastatic spread of renal cell carcinoma with ipsilateral involvement of the adrenal gland occurs in up to 10% at surgery Lymphoma can also involve the adrenal glands; the adrenals will typically maintain an adreniform shape; bilateral involvement is seen in 1/3 of cases.
Common primaries: Lung, breast, kidney
Pattern of dissemination: peritoneum / omentum
Disseminated carcinomatosis to the peritoneum and omentum occurs when tumors penetrate beyond the primary organ of origin to spread directly along the adjacent peritoneal surfaces. Tumors of the stomach, colon, pancreas, and ovary are most common to do so. The appearance of dissemination can produce a distinctive appearance ranging from stranding to small nodules to discrete masses. The transverse mesocolon, gastrocolic ligament, and gastrosplenic ligament are important pathways of tumor spread for stomach and colon primaries. Ovarian cancer spreads diffusely along all mesothelial surfaces. Ovarian cancer metastases often produce a "scalloped" appearance to the adjacent solid organs, and may calcify.
Common primaries :Ovary, colon, stomach
Pattern of dissemination: small bowel
Lung cancer and melanoma represent the most common primary tumors to metastasize to the small intestine. Involvement is typically by hematogenous dissemination of tumor. Other common primaries to seed the small intestine include the kidney and breast. Metastatic lesions present as well defined masses within the bowel lumen. Intussusception may be the presenting finding at CT evaluation. Intraperitoneal seeding and direct invasion represent other pathways for small bowel metastases. Lymphoma can also commonly involve the small bowel. Common primaries: Lung, melanoma, lymphoma
Pattern of dissemination: kidney
Metastases to the kidney are not rare. Involvement is typically via hematogenous dissemination. Common primary tumors include lung, breast, colon, melanoma. Most metastases are small and hypovascular, enhancing less than normal renal parenchyma following contrast administration. Larger lesions can be indistinguishable from renal cell carcinoma. A distinguishing feature of primary renal tumors is renal vein invasion, which is very rare with metastases. Lymphomatous involvement of the kidneys is also quite common. Multiple masses, a solitary mass, or diffuse renal enlargement are typical CT patterns of lymphoma.
Common primaries: Lung, lymphoma
Pattern of dissemination: ovary
Metastatic involvement of the ovaries should always be considered in the differential diagnosis of patients with bilateral adnexal masses. Krukenburg tumors, classically described from metastatic adenocarcinoma of GI primary, can mimic the CT and sonographic appearance of primary ovarian cancer and present as the initial site of involvement. Involvement is typically by hematogenous dissemination of tumor. Other possible primary tumor sites include the breast and lung.
Pattern of dissemination: retroperitoneum
Retroperitoneal adenopathy is a very common finding in metastatic dissemination from a multitude of possible primaries, as well as lymphoma. Adenocarcinoma is most common solid organ primary, and common sites include the colon, stomach, pancreas, lung, and breast. At times the primary remains "unknown" even after exhaustive work-up. Pelvic tumors, such as prostate or endometrial cancer, can bypass pelvic nodes and also present with paraaortic nodes. One characteristic tumor metastasis from testicular cancer, which typically shows initial retroperitoneal drainage into a "sentinal" node located in the renal perihilar region. Tumor spread is commonly unilateral. Nodes may demonstrate low attenuation from intratumoral necrosis, especially bulky nodes from seminoma or embryonal carcinomas. .
Common primaries:Adenocarcinoma (GI tract)
Common primaries: Adenocarcinoma, lymphoma
Pattern of dissemination: pelvic lymph nodes
Pelvic nodal metastases are most commonly seen with disseminated pelvic primaries, as well as lymphoma. Pelvic tumors, such as endometrial and cervical cancer, spread along the uterine vessels to the internal, external, and common iliac nodes. Prostate cancer typically spreads first to the hypogastric and obturator nodes, and less commonly to external iliac lymph nodes. Bladder cancer spreads through the major lymphatic trunks that drain into the external iliac node chain. Tumors from the posterior bladder wall may drain into the internal iliac chain.
Common primaries:prostate, cervix, lymphoma
Pattern of dissemination: subcutaneous tissues
Metastatic nodules in the subcutaneous tissue are typically the result of hematogenous dissemination. Common primaries include melanoma, lymphoma, or adenocarcinoma from primaries such as the lung, kidney, or breast. Multisystemic involvement is a hallmark or lymphoma and melanoma, and a careful search of the subcutaneous tissues should be part of every CT evaluation.
Common primaries: Melanoma, lymphoma, adenocarcinoma
Note:this review is based on an exhibit from Urban BA et al.
© 1999-2020 Elliot K. Fishman, MD, FACR. All rights reserved.


Marapharm has entered into an agreement to purchase a Medical Delivery Service with the specific and limited purpose to deliver, facilitate or coordinate cannabis transactions between qualified patients and caregivers. The delivery service is located in Rancho Mirage, located in the Coachella Valley, California. The Valley connects with the Greater Los Angeles area to the West, population 19,000,000. The population of the valley is 500,000 and in addition has 3.5 million annual conventioneers and tourists.
Marapharm purchased 80% of the shares of Moringa Cooperative, Inc. "Moringa" and 20% ownership remains with the founding group, who will continue to operate the business. Presently the DBA (doing business as) is MedicalDriveBy and a change to Marapharm Delivery or other names is being considered. Terms of the transaction are $300,000 US. Additional funds may be required for further delivery vehicles, expansion and working capital. Moringa is a cooperative corporation organized under the California Consumer Cooperative Corporation Law. The purpose of the corporation is to engage in any lawful activity and specific to cannabis transactions in California.
"Delivery services for cannabis are a big profit business in other locations in the United States and we're excited for our first one to be in California. Marapharm's business model is to be part of the entire marijuana experience in different States and countries, to grow it, sell it and now to deliver it. This is great diversity!" Linda Sampson, Marapharm, CEO.


The utility sector is vast and covers a wide variety of categories including gas, water, telecoms and power. Due to this, significant infrastructures are required to contain powerful equipment needed for the necessary requirement, ranging from huge national grids right down to the small stand-alone buildings and kiosks, often situated near residential areas.
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Designed to be installed at remote sites where there is a high risk of vandalism, our doorsets are secure and have been engineered to last. For locations where security is a notable issue, our security door range is also available with LPCB certification to LPS 1175 SR1, SR2, SR3 and SR4 respectively, and with optional CERTIFIRE accreditation to FD240 dependant on specification.
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Home » Stocks » Micron Stock » MU Stock: Here's Why Billionaire D.E. Shaw Is Bullish on Micron Technology
https://www.profitconfidential.com/stock/mu-stock-heres-why-billionaire-d-e-shaw-is-bullish-on-micron-technology/ MU Stock: Here's Why Billionaire D.E. Shaw Is Bullish on Micron Technology Alessandro Bruno, BA, MA Profit Confidential 2015-12-22T12:48:51Z 2017-08-21 04:35:45 Micron Technology Inc NASDAQ:MU Huawei Intel NAND semiconductors Inotera Billionaire D.E. Shaw is buying up shares of Micron Technology Inc.'s (NASDAQ:MU) stock hand over fist. Here's why. Micron Stock,Stocks https://www.profitconfidential.com/wp-content/uploads/2015/12/Micron-Technology-stock.jpg
The Smart Money Is Buying MU Stock
Micron Technology, Inc. (NASDAQ:MU), the U.S.-based microchip manufacturer that is trading around $14.50, is less than half the value it was a year ago. Is it time to bail on MU stock? Definitely not, especially given that one of the world's smartest investors D.E. Shaw is buying up MU shares hand over fist. Billionaire D.E. Shaw has increased his stake in Micron Technology by 38% in the last quarter. (Source: "D. E. Shaw & Co. Inc 13-F Filing," Securities and Exchange Commission, December 11, 2015). One of the reasons explaining D.E. Shaw's optimism over MU stock is that Micron Technology is developing a new type of computer memory with Intel Corporation (NASDAQ:INTC), which is said to be more efficient than are its predecessors.
D.E. Shaw Increases Stake in Micron Technology Stock
The technology is the first new type of memory since the launch of NAND flash memory, which led to the development of the smartphone with the potential of being up to a thousand times faster. Micron says the new technology will allow for much faster access to data. Intel and Micron have already started production in their joint plant in Lehi, Utah. The sampling circuit 128 Gbits is planned for this year and the technology itself is based on a three-dimensional structure with no transistor memory cells. In early December, at the International Electron Devices Meeting (IEDM), the world's pre-eminent semiconductor conference, Micron and Intel discussed their 3D-NAND flash technology, now sampling to customers. (Source: "Intel/Micron Detail Their 3D-NAND at IEDM," Solid State Technology, December 10, 2015.) Micron has completed the final 67% acquisition of the Taiwanese memory-chip technology firm Inotera for $3.2 billion. Inotera was founded in 2003 as a joint venture between Nanya Technology and Infineon Technologies. Micron, which had taken over the latter's shares in 2008, effectively became the sole customer for the Taiwanese company's production. (Source: "Micron Technology to Buy All of Taiwanese Chip Company Inotera," The Wall Street Journal, December 14, 2015.) MU stock could also see gains thanks to Huawei, one of the world's fastest-growing cell phone manufacturers. Huawei wants to improve its devices, starting with the hardware. The Chinese company already produces its own processors, but it wants to become autonomous in GPU and memory for smartphones and tablets. Nevertheless, a wise company, bent on fast expansion, cannot simply start from scratch and Micron Technology is ideally suited to contribute to the design and implementation of storage hardware. Plus, the company already possesses economies of scale in this area. Micron Technology, based in Boise, Idaho, produces various types of semiconductor devices, including DRAM, NAND Flash and NOR, and solid-state storage (SSD) units. Micron also manufactures storage devices for consumers, marketed under the Lexar and Crucial brands. Together, Micron and Intel have formed a joint venture, IM Flash Technologies, which manufactures the NAND flash memory. Thomson Reuters named Micron among the 100 most innovative companies in the world in 2012 and 2013. (Source: Top 100 Global Innovators, Thomson Reuters, Last Accessed Dec 22, 2015.) Micron Technology is one of the world's top three semiconductor companies, falling behind Samsung and SY Hynix. Meanwhile, China has become ever more ambitious in creating its own memory and data storage industry. There, Micron Technology remains a major target for acquisition, despite the likely hostility of U.S. authorities. Chinese companies will also look for other ways to benefit from Micron's experience and market reach. The technology has attracted attention from China's Tsinghua Unigroup, because China, the largest semiconductor consumer, accounts for almost half of computer chip demand for domestic and export markets, even if it has to import 90% integrated circuits.
The Bottom Line on MU Stock
Zhao Weiguo, president of Tsinghua Unigroup, has already met with Micron's board members to gauge the feasibility of an acquisition with U.S. authorities. Should it be rejected on national security grounds, as noted by Senator John McCain, Tsinghua could still ally with Micron to enable it to develop its sales in China, while negotiating a production on Chinese soil of flash memory drives and other devices. (Source: "Tsinghua's Latest Deal Adds Chairman of Micron Venture," Bloomberg, October 12, 2015.) All the more reason to be bullish on MU stock. Stay in the loop. Follow Alessandro on Facebook and Twitter.
By Alessandro Bruno, BA, MA
Alessandro Bruno, BA, MA
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MU Stock: Here's Why Billionaire D.E. Shaw Is Bullish on Micron Technology
By Alessandro Bruno, BA, MA Published : December 22, 2015
Micron Technology, Inc. (NASDAQ:MU), the U.S.-based microchip manufacturer that is trading around $14.50, is less than half the value it was a year ago. Is it time to bail on MU stock? Definitely not, especially given that one of the world's smartest investors D.E. Shaw is buying up MU shares hand over fist.
Billionaire D.E. Shaw has increased his stake in Micron Technology by 38% in the last quarter. (Source: "D. E. Shaw & Co. Inc 13-F Filing," Securities and Exchange Commission, December 11, 2015). One of the reasons explaining D.E. Shaw's optimism over MU stock is that Micron Technology is developing a new type of computer memory with Intel Corporation (NASDAQ:INTC), which is said to be more efficient than are its predecessors.
The technology is the first new type of memory since the launch of NAND flash memory, which led to the development of the smartphone with the potential of being up to a thousand times faster. Micron says the new technology will allow for much faster access to data.
Intel and Micron have already started production in their joint plant in Lehi, Utah. The sampling circuit 128 Gbits is planned for this year and the technology itself is based on a three-dimensional structure with no transistor memory cells. In early December, at the International Electron Devices Meeting (IEDM), the world's pre-eminent semiconductor conference, Micron and Intel discussed their 3D-NAND flash technology, now sampling to customers. (Source: "Intel/Micron Detail Their 3D-NAND at IEDM," Solid State Technology, December 10, 2015.)
Micron has completed the final 67% acquisition of the Taiwanese memory-chip technology firm Inotera for $3.2 billion. Inotera was founded in 2003 as a joint venture between Nanya Technology and Infineon Technologies. Micron, which had taken over the latter's shares in 2008, effectively became the sole customer for the Taiwanese company's production. (Source: "Micron Technology to Buy All of Taiwanese Chip Company Inotera," The Wall Street Journal, December 14, 2015.)
MU stock could also see gains thanks to Huawei, one of the world's fastest-growing cell phone manufacturers. Huawei wants to improve its devices, starting with the hardware. The Chinese company already produces its own processors, but it wants to become autonomous in GPU and memory for smartphones and tablets. Nevertheless, a wise company, bent on fast expansion, cannot simply start from scratch and Micron Technology is ideally suited to contribute to the design and implementation of storage hardware. Plus, the company already possesses economies of scale in this area.
Micron Technology, based in Boise, Idaho, produces various types of semiconductor devices, including DRAM, NAND Flash and NOR, and solid-state storage (SSD) units. Micron also manufactures storage devices for consumers, marketed under the Lexar and Crucial brands.
Together, Micron and Intel have formed a joint venture, IM Flash Technologies, which manufactures the NAND flash memory.
Thomson Reuters named Micron among the 100 most innovative companies in the world in 2012 and 2013. (Source: Top 100 Global Innovators, Thomson Reuters, Last Accessed Dec 22, 2015.) Micron Technology is one of the world's top three semiconductor companies, falling behind Samsung and SY Hynix.
Meanwhile, China has become ever more ambitious in creating its own memory and data storage industry. There, Micron Technology remains a major target for acquisition, despite the likely hostility of U.S. authorities.
Chinese companies will also look for other ways to benefit from Micron's experience and market reach. The technology has attracted attention from China's Tsinghua Unigroup, because China, the largest semiconductor consumer, accounts for almost half of computer chip demand for domestic and export markets, even if it has to import 90% integrated circuits.
Zhao Weiguo, president of Tsinghua Unigroup, has already met with Micron's board members to gauge the feasibility of an acquisition with U.S. authorities. Should it be rejected on national security grounds, as noted by Senator John McCain, Tsinghua could still ally with Micron to enable it to develop its sales in China, while negotiating a production on Chinese soil of flash memory drives and other devices. (Source: "Tsinghua's Latest Deal Adds Chairman of Micron Venture," Bloomberg, October 12, 2015.)
All the more reason to be bullish on MU stock.
Stay in the loop. Follow Alessandro on Facebook and Twitter.
Subject: Gold: The Stock Contrarian Investors' Best Play of the Decade

redpajama_set_name: RedPajamaCommonCrawl


Ask 100 different persons about true happiness and you will get 100 different answers. Some will tell you that real happiness is in being rich and popular, others will tell you that happiness has nothing to do with money or fame while a third group will tell you that real happiness is in finding a loving relationship.
Actually all of the answers are incorrect because what makes me happy is very different from what makes you happy.
The biggest mistake people make when they try to seek happiness is that they follow generic advice that will never work except for a few of them because each one of us have got their own happiness keys.
If you want to be happy then you must find customized happiness tips that matches your own needs and this is what this article is all about.
Finding happiness within: Some people claim that happiness can be found through meditation or Yoga. While these practices can help in reducing stress and in improving your mood still true happiness would never be found before you get a hold of your happiness keys. See Why Meditation never worked for you.
I know that many books and articles have told you that you can be happy on the spot once you decide to do so but if you had a chance to meet the authors of those articles and books then you will discover that they are unhappy.
In order to be happy you have to fight for it. Improving your life, getting rid of your problems and changing the things you dislike about your life are all actions that require a lot of determination and hard work.
When you manage to get all of these tasks completed you will find yourself a much happier person and most of your bad moods will disappear. See also How to program your mind to become happy.
Each day there are so many things that you might be doing that might be lowering your happiness levels and making you sad. Negative thinking patterns, self defeating thoughts and getting exposed to negative sources are among the common habits that can make you unhappy.
Why cant i be happy with my life?
How to be really happy?


text:
Muzikologija je znanost o glazbi. Riječ dolazi od starogrčkog musike (glazba) i logos (riječ). Hrvatski izraz za ovu znanost je glazboslovlje

Istražuje fenomen glazbe iz perspektive raznih relevantnih disciplina uključujući i humanističke znanosti, kulturološki, prirodoslovni i sociološki pristup.

Izvori

Vanjske poveznice
 Hrvatsko muzikološko društvo
 Američko muzikološko društvo

Glazba

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Resources on Hip disarticulation from Pubget.
Resources on Hip disarticulation and related topics in OrthopaedicsOne spaces.
. Hip disarticulation. OrthopaedicsOne Articles. In: OrthopaedicsOne - The Orthopaedic Knowledge Network. Created Jun 05, 2010 13:42. Last modified Jul 24, 2012 03:25 ver.3. Retrieved 2019-04-20, from https://www.orthopaedicsone.com/x/bAoCAg.


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Definition of now and then
: from time to time : occasionally now and then we go off to the country
Synonyms More Example Sentences Learn More about now and then
Synonyms for now and then
here and there, now, occasionally, sometimes
Examples of now and then in a Sentence
we do go to the library now and then, but not as often as we should
Everybody plays badly now and then, but Woodland would not allow the pressure of coming off a major win to be an excuse. — J.l. Kirven, Detroit Free Press, "Rocket Mortgage Classic: U.S. Open champ Gary Woodland could miss cut," 27 June 2019 But every now and then there are Sikhs like Pal, with long salt-and-pepper beards, colorful turbans and thick Indian accents. — San Diego Union-Tribune, "Sikh drivers are transforming U.S. trucking. Take a ride along the Punjabi American highway," 27 June 2019 The children described in the book range from the impressive to the banal to the amusing to the infuriating, and every now and then there's a catastrophe that stops you in your tracks. — Titus Techera, National Review, "A Teacher Confronts Reality," 26 June 2019 Every now and then a viral trend comes along that poses a major health threat. — Samantha Lauriello, Health.com, "The Viral Sunburn Tattoo Trend Is Seriously Dangerous—Here's Why," 10 June 2019 However, a few veggies now and then, especially if the cat is craving them, is OK. — Joan Morris, The Mercury News, "Seemingly benign skunk deterrent can be dangerous for cats," 14 June 2019 Every now and then, though, a report would make its way into the zeitgeist that was just...bizarre. — Christopher Rosa, Glamour, "11 Meghan Markle Headlines From This Year That Are So Ridiculous, You Have to Laugh," 25 Dec. 2018 Every now and then, for example, a narrator, voiced by Willem Dafoe, comments on Celeste's life in a mock-heroic tone that may have been meant to defuse the grandiosity, but only enhances it. — Joe Morgenstern, WSJ, "'Vox Lux' Review: Dressing Sharp, Feeling Flat," 6 Dec. 2018 Jewel smuggling, however, like any smuggling designed merely to evade duties, was confined to a comparatively small professional class, with now and then an occasional traveler who attempted to bring in something for his own use. — Popular Mechanics Editors, Popular Mechanics, "Rewind: What Guarding Uncle Sam's Borders Was Like in 1925," 11 Feb. 2019
These example sentences are selected automatically from various online news sources to reflect current usage of the word 'now and then.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.
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The first known use of now and then was in the 15th century
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ANTIOXIDANT, ANTIBACTERIAL AND GUT MODULATING ACTIVITIES OF KALANCHOE LACINIATA.
@article{Iqbal2016ANTIOXIDANTAA,
title={ANTIOXIDANT, ANTIBACTERIAL AND GUT MODULATING ACTIVITIES OF KALANCHOE LACINIATA.},
author={Shahid Iqbal and Qurrat Ul Ain Jamil and N S Mohd Jamil and Mohammad Kashif and Rehan Mustafa and Qaiser Jabeen},
journal={Acta poloniae pharmaceutica},
S. Iqbal, Q. Jamil, +3 authors Q. Jabeen
Acta poloniae pharmaceutica
Kalanchoe laciniata (L.) DC. (Crassulaceae) is a widely distributed plant in Africa and Asia. Traditionally, various communities use this plant for the treatment of a variety of ailments such as gut prob- lems, allergic conditions and wounds. The current study was designed to explore the antibacterial, antioxidant and gut modulating activities of K. laciniata in order to provide scientific rationale for its traditional uses. Phytochemical compounds were assessed through screening 70% crude…
ptfarm.pl
Crassulaceae
Kalanchoe pinnata leaf extract
Calcium Channel
Anti-Bacterial Agents
Illness (finding)
Gastrointestinal Microbiome
Antibacterial Activity of Kalanchoe mortagei and K. fedtschenkoi Against ESKAPE Pathogens
Nicholas Richwagen, J. T. Lyles, Brandon Dale, C. Quave
Front. Pharmacol.
Evaluated in vitro antibacterial effects of two previously unexplored species against a panel of multidrug-resistant bacteria reveal K. fedtschenkoi to be a plant of medicinal interest, and future research should aim to characterize the bioactivity of this species and its active constituents through bioassay-guide fractionation.
Cytotoxic effect of Kalanchoe flammea and induction of intrinsic mitochondrial apoptotic signaling in prostate cancer cells.
Iván Arias-González, A. García-Carrancá, J. Cornejo-Garrido, C. Ordaz-Pichardo
Journal of ethnopharmacology
K. flammea is a potential candidate for the development of new drugs for the treatment of prostate cancer, but to propose their use in clinical trials, additional studies are required to understand their pharmacokinetic behavior, as well as theDevelopment of a suitable pharmaceutical form.
Biocultural Significance and Toxicity
Gideon F. Smith, E. Figueiredo, A. V. van Wyk
Kalanchoe (Crassulaceae) in Southern Africa
Abstract Bufadienolides are cardiac glycosides that characterise members not only of the genus Kalanchoe but also of Crassulaceae subfam. Kalanchooideae as a whole. These compounds are neurotoxins…
Vasodilating, spasmolytic, inotropic and chronotropic activities of curcuminoids from Curcuma longa in isolated organ preparations of guinea pigs.
Q. Jamil, S. M. Iqbal, W. Jaeger, C. Studenik
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Interestingly, ferulic acid, feruloyl methane and vanillin demonstrated no pharmacologicical activity at all in the various isolated organs, while curcumin and bisdemethoxycurcumin showed high uptake into the various tissues where concentrations correlated with pharmacological activity.
Bangladesh J
S. Prodhan, A. Komamine
Genetic transformation of rice (Oryza sativa L.) mediated by Agrobacterium tumefaciens has been confirmed for japonica varieties and extended to include more recalcitrant indica varieties.…
"J."
G. G. Stokes
however (for it was the literal soul of the life of the Redeemer, John xv. io), is the peculiar token of fellowship with the Redeemer. That love to God (what is meant here is not God's love to men)…
Acta Pol
Pharm. Drug Res. 70, 115
Lebensm
Wiss. Technol. Food Sci. Technol. 44, 347
Afr. J. Bot. 77, 170
Asian Pac
J. Trop. Med. 3, 898
Saudi J
Biol. Sci. 17, 57
Food Chem
Toxicol. 47, 2083
Pharmacogn
Rev. 3, 364
Medicinal plants of the AsiaPacific: drugs
for the future?,


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text:
Come rain or shine there is so much to see and do in Cornwall. There are hundreds of places to visit, far too many to list. From castles, historic houses and gardens to beaches, zoos, fishing villages and churches.
For the more active there is paddle boarding, coasteering, surfing, kite surfing, gokarting, horse riding, golf football, fun pools and parks, bike riding, kayaking, canoeing and golf to name just a few. We can help you with obtaining theatre tickets, booking events or organising a group event here on the farm such as archery, lazer clay shooting and clay shooting
If you enjoy walking, there are numerous woodland and coastal walks and Tor View is on the 26-mile Saints' Way walking route from Padstow to Fowey. If cycling is more your thing, bicycles can be hired from Padstow or Bodmin to help you complete the 25 mile Camel Trail from Padstow to Helland on the Moor. There is also a new set of cycle routes at Lanhydrock, (a fabulous national trust property in Bodmin) where bicycles can be hired and a great set of off track routes at Cardinham Woods, Bodmin.
Pencarrow House and gardens, with woodland trails, are also near Bodmin. Nearer the South coast, there is Restormel Castle in Lostwithiel and of course the famous Eden Project is just 10 minutes drive from Tor View and the Lost Gardens of Heligan, 30 minutes away. The Eden project houses the world's largest global gardens and house plants from all around the world. Nearer to the farm is Luxulyan Valley which has a 650 feet long viaduct and at Goss Moor, there is a national nature reserve, which is the largest wetland and heathland in the south west.
We have plenty of leaflets in both properties giving you ideas of where to go and what to do.
torview@btinternet.com
Tor View,
Corgee Farm,
Luxulyan,
Bodmin,
PL30 5DS
Copyright © 2020 Tor View Barn, All rights reserved. Privacy Policy


The Master of Arts in Teaching (MAT) program is designed for students seeking initial teacher certification in Mathematics. The program shares the philosophy and conceptual base of the Zucker Family School of Education: Preparing Principled Educational Leaders who are knowledgeable, reflective, and ethical. In addition, students must demonstrate an understanding of essential knowledge and its application to the classroom through field experiences and a professional internship. Some of those areas of knowledge include human development, education foundations and research, as well as an understanding of the academic content the student proposes to teach.
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An official transcript of the baccalaureate degree and all other undergraduate or graduate work from accredited colleges and universities. Applicants are expected to have a cumulative undergraduate GPA of 2.5 or higher. Applicants with less than a 2.5 GPA may appeal to the Department of Mathematics and Computer Science, and their application will be reviewed by the Program Director and the Department Head. The department recommendation will be forwarded to the Dean of Science and Mathematics for final action.
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COURSES CONTINUALLY UPDATED! Available courses such as MATH 514 cover topics including assessment, engaging students in classroom discourse, supporting struggling learners, and fostering equity in the mathematics classroom.