text:
Chromatin roadblocks to reprogramming 50 years on
Peter J Skene1 &
Steven Henikoff1
A half century after John Gurdon demonstrated nuclear reprogramming, for which he was awarded the 2012 Nobel Prize in Physiology or Medicine, his group provides insights into the molecular mechanisms whereby chromatin remodeling is required for nuclear reprogramming. Among the issues addressed in Gurdon's latest work are the chromatin impediments to artificially induced reprogramming, discovered by Shinya Yamanaka, who shared the award with Gurdon.
See research article: http://www.epigeneticsandchromatin.com/content/5/1/17
Nuclear reprogramming is the name given to the change that occurs in the nucleus of a somatic cell when it is induced to revert from its differentiated state and assumes a pluripotent state, from which it can adopt any cellular identity, given the appropriate cues. This is the basis for much of the promise in regenerative medicine, for example in the repopulation of bone marrow following chemotherapy. In a laboratory setting, reprogramming can be achieved in two ways. In the first, the somatic cell nucleus is transferred into an oocyte. Here the oocyte provides the necessary factors to reprogram the somatic nucleus, which is in principle then capable of recapitulating the entire developmental program. In the second, expression of four key transcription factors (Oct4, Sox2, Klf4 and c-Myc) is sufficient to reprogram a somatic cell to produce what is known as an induced pluripotent stem cell (iPSC) state, originally discovered by Shinya Yamanaka and colleagues [1].
There are, however, several hurdles to be overcome before reprogrammed cells can be used in a therapeutic setting. Currently, the generation of iPSCs is typically slow and the reprogramming of somatic cells from accessible adult tissues, which is most applicable for therapeutic uses, is particularly inefficient because donor cells from these tissues are at a late stage of differentiation [2]. It also appears that iPSCs are not truly equivalent to the pluripotent embryonic stem cell, as iPSCs display a reduced differentiation capacity that is biased to the cell lineage of origin. This is consistent with the observation that iPSCs may retain a memory of the somatic cell gene expression pattern. An important aim of research in this field, therefore, is a better understanding of the mechanism of reprogramming that may lead to improvements in the efficiency and fidelity with which pluripotent stems cells can be generated. Such an understanding is beginning to emerge from studies on chromatin remodeling in the generation of pluripotent stem cells.
Resetting the chromatin landscape
Studies on iPSC generation have suggested that chromatin at the promoters and enhancers of pluripotency genes in somatic cells is in a repressed state characterized by modifications such as DNA methylation and histone deacetylation, and this is a roadblock to reprogramming, which is thus promoted by inhibitors of DNA methylation and histone deacetylation [3]. c-Myc is thought to function as a catalyst in this process, by increasing the rate of cell proliferation and perhaps transcriptional elongation, both of which result in large-scale chromatin remodeling.
In the study reported in Epigenetics & Chromatin, John Gurdon and colleagues describe the investigation of reprogramming that is independent of DNA replication, by transferring mammalian somatic cell nuclei into Xenopus oocytes, which are mitotically arrested, and following the resulting chromatin changes [4]. They focused on the incorporation of the histone variant H3.3, which is a hallmark of sites of high nucleosome turnover, and is associated with active genes and their regulatory elements [5, 6]. When they microinjected mRNA encoding epitope-tagged H3.3 into the oocytes prior to nuclear transfer, they observed early incorporation of H3.3 into the pluripotency gene Oct4 coincident with the onset of transcription of the gene. To check the requirement for H3.3, they injected into the oocyte polyclonal antibodies against HIRA, the chaperone responsible for the incorporation of histone H3.3 into chromatin, and were able to show that this abrogates transcriptional reprogramming. They also showed, by the use of the polymerase II inhibitor alpha-amanitin, that H3.3 incorporation depends on transcriptional activity as well as HIRA. Impaired reprogramming in the absence of HIRA and H3.3 deposition could not be compensated for by the increased deposition of histone variant H3.2. These results imply that some specific function is attributable to the H3.3 deposition pathway in promoting reprogramming, and raises the question of what that function might be.
Reprogramming is far less efficient than differentiation and this may reflect the need for reprogramming factors to overcome changes to the chromatin environment that occur with differentiation. Embryonic stem cells are characterized by a highly dynamic chromatin state compared with that of more differentiated cell types [7], and pluripotency genes in particular have been shown to gain repressive chromatin marks during differentiation. It is, however, at these silenced sites that the reprogramming factors must bind to elicit their effects. Whilst c-Myc binding occurs early in the reprogramming process, Oct4, Sox2 and to a lesser extent Klf4, which co-occupy a large number of promoters, bind only later during reprogramming. Delayed binding of Oct4, Sox2 and Klf4, presumably because of the repressive chromatin environment at their binding sites, is thought to be a major roadblock in the reprogramming process.
As transcription factor binding sites associated with active genes are marked by rapidly turning-over nucleosomes, it is probable that during reprogramming the nucleosomes at the Oct4/Sox2/Klf4 sites become remodeled to contain H3.3. The high turnover observed at regulatory sites might be required to prevent sites from becoming stably occupied by nucleosomes, which would impede transcription factor binding and therefore reprogramming. This removal of repressive chromatin and replacement with H3.3 may facilitate transcription factor binding and successful reprogramming. Perhaps, therefore, HIRA-dependent H3.3 deposition is functioning to promote pluripotency. This is consistent with the observation that HIRA deficient embryonic stem cells rapidly differentiate [7]. It also, however, raises the question of how histone H3.3 may confer a more accessible chromatin environment.
Histone H3.3: striking a balance
One obvious possibility is that the high turnover of H3.3-containing nucleosomes reflects some intrinsic instability. However, H2A/H3.3-containing nucleosomes seem to be just as stable in vitro as H2A/H3.1-containing nucleosomes [8]. Another possibility is that histone H3.3 accumulates at these high turnover sites as a gap-filling mechanism after the eviction of nucleosomes following transcription or the activity of chromatin remodelers. The observations of Gurdon and colleagues, however, indicate failure of histone variant H3.2 to compensate for the lack of H3.3 deposition, suggesting that there is more to H3.3 deposition in the reprogramming process than simple gap filling.
If there is nothing intrinsic to the amino acid sequence of H3.3 that favors a permissive chromatin state, then perhaps the deposition process itself is key. Perhaps, therefore, a specific post-translational modification of H3.3 might be associated with HIRA-dependent deposition, or an additional chromatin remodeling step at the point of H3.3 deposition might promote an active chromatin conformation and accessibility to the underlying DNA sequence. iPSC generation has been suggested to be a stochastic process [9], which at a molecular level may reflect the stochastic nature of binding by the reprogramming factors to their target sequences due to transient exposure of these sites in the repressive chromatin environment [10]. Increases in the deposition of H3.3 may therefore facilitate reprogramming by increasing the frequency of exposure of these binding sites (Figure 1a).
Opposing roles of histone H3.3 in reprogramming. (a) In somatic cells, pluripotency genes are in a repressive chromatin environment. Transient binding by a reprogramming factor to its binding site results in histone H3.3 incorporation, which in turn results in a more permissive chromatin structure and enhanced accessibility of the binding site. These chromatin changes increase the probability of concomitant binding of Oct4, Sox2 and Klf4 and activation of the target pluripotency gene. (b) Active genes are marked by high levels of histone H3.3. During DNA replication H3.3 is diluted out by the replication-dependent incorporation of histone H3.1. Depending on appropriate cues the gene will either become re-activated or become silenced. During reprogramming, tissue-specific genes become progressively silenced. High levels of H3.3 expression, however, increase the probability of H3.3 incorporation and therefore promote the memory of the somatic cell gene expression pattern.
A key question for future studies is whether the overexpression of HIRA and/or histone H3.3 may accelerate reprogramming and increase the efficiency of iPSC generation by allowing the remodeling of transcription factor binding sites. A second, related question is whether such overexpression might provide the necessary replication-independent chromatin remodeling, thereby reducing the requirement for c-Myc as a catalyst. This would be desirable because c-Myc, which is thought to aid reprogramming by increasing the rate of cell proliferation and thereby genome-wide chromatin remodeling, is a proto-oncogene; there are thus naturally concerns about its induced expression in the generation of iPSCs as a therapeutic agent.
There is, however, a potential pitfall in the overexpression of HIRA/H3.3 in reprogramming. Whilst it may allow the remodeling of repressive chromatin to promote gene activation, histone H3.3 has also been shown in an earlier study by Gurdon and colleagues [11] to potentiate transcriptional memory (Figure 1b). In that study, using reprogramming via somatic cell nuclear transfer into enucleated Xenopus oocytes, they showed that overexpression of histone H3.3 increased the frequency at which nuclei maintained their original transcriptional program, as determined by MyoD expression. They have since suggested that the unusually high H3.3 content in eggs is responsible for this transcriptional memory [2]. This may suggest the need for a delicate balance in the overexpression of HIRA and/or H3.3, in which factor binding will be facilitated through chromatin decondensation, but transcriptional memory will not be evoked. Given the evidence that transcriptional memory in iPSCs may cause some of the observed limitations to the regenerative applications of these cells, clearly the operation of the H3.3 pathway in both reprogramming and memory will need to be taken into account in any manipulation of that pathway for therapeutic purposes. Gurdon's latest work thus forges a connection, through the changes to chromatin required for reprogramming, between the two 2012 Nobel Prize-winning papers published almost a half century apart.
Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006, 126: 663-676. 10.1016/j.cell.2006.07.024.
Pasque V, Jullien J, Miyamoto K, Halley-Stott RP, Gurdon JB: Epigenetic factors influencing resistance to nuclear reprogramming. Trends Genet. 2011, 27: 516-525. 10.1016/j.tig.2011.08.002.
PubMed CAS PubMed Central Article Google Scholar
Plath K, Lowry WE: Progress in understanding reprogramming to the induced pluripotent state. Nat Rev Genet. 2011, 12: 253-265. 10.1038/nrg2955.
Jullien J, Astrand C, Szenker E, Garrett N, Almouzni G, and Gurdon JB: HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes. Epigenetics Chromatin. 2012, 5: 17-10.1186/1756-8935-5-17.
Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, Boydston EA, Holmes MC, Gregory PD, Greally JM, Rafii S, Yang C, Scambler PJ, Garrick D, Gibbons RJ, Higgs DR, Cristea IM, Urnov FD, Zheng D, Allis CD: Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 2010, 140: 678-691. 10.1016/j.cell.2010.01.003.
Deal RB, Henikoff JG, Henikoff S: Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones. Science. 2010, 328: 1161-1164. 10.1126/science.1186777.
Meshorer E, Yellajoshula D, George E, Scambler PJ, Brown DT, Misteli T: Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell. 2006, 10: 105-116. 10.1016/j.devcel.2005.10.017.
Thakar A, Gupta P, Ishibashi T, Finn R, Silva-Moreno B, Uchiyama S, Fukui K, Tomschik M, Ausio J, Zlatanova J: H2A.Z and H3.3 histone variants affect nucleosome structure: biochemical and biophysical studies. Biochemistry. 2009, 48: 10852-10857. 10.1021/bi901129e.
Hanna J, Saha K, Pando B, van Zon J, Lengner CJ, Creyghton MP, van Oudenaarden A, Jaenisch R: Direct cell reprogramming is a stochastic process amenable to acceleration. Nature. 2009, 462: 595-601. 10.1038/nature08592.
Ahmad K, Henikoff S: Modulation of a transcription factor counteracts heterochromatic gene silencing in Drosophila. Cell. 2001, 104: 839-847. 10.1016/S0092-8674(01)00281-1.
Ng RK, Gurdon JB: Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. Nat Cell Biol. 2008, 10: 102-109. 10.1038/ncb1674.
PJS is a Damon Runyon Fellow supported by the Damon Runyon Cancer Research Foundation (DRG-2110-12).
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA
Peter J Skene & Steven Henikoff
Peter J Skene
Steven Henikoff
Correspondence to Steven Henikoff.
Skene, P.J., Henikoff, S. Chromatin roadblocks to reprogramming 50 years on. BMC Biol 10, 83 (2012). https://doi.org/10.1186/1741-7007-10-83
Transcription Factor Binding Site
Chromatin Remodel
Somatic Cell Nuclear Transfer
Histone Variant
Focus on stem cells


Column 1), _ Address:="mailto:[email protected]? subject=Sales Report", _ Sub Address:="", _ Screen Tip:="Critical", _ Text To Display:="Mail this Figure" Application. You do not have to worry about missing links anymore.
Here, in this article we will see how we can add Hyperlinks in Excel using VBA. ' -------------------------------------------------------------------------------- ' Copyright 1999-2018, Shyam Pillai, All Rights Reserved.' -------------------------------------------------------------------------------- ' You are free to use this code within your own applications, add-ins, ' documents etc but you are expressly forbidden from selling or ' otherwise distributing this source code without prior consent.Declare Function Find Window Lib "user32" Alias "Find Window A" _ (By Val lp Class Name As String, _ By Val lp Window Name As Long) As Long ' Use Lock Window Update to prevent/enable window refresh Declare Function Lock Window Update Lib "user32" _ (By Val hwnd Lock As Long) As Long ' Use Update Window to force a refresh of the Power Point window Declare Function Update Window Lib "user32" (By Val hwnd As Long) As Long Property Let Screen Updating(State As Boolean) Static hwnd As Long Dim Version No As String ' Get Version Number If State = False Then Version No = Left(Application. Version, ".") - 1) ' Get handle to the main application window using Class Name Select Case Version No Case "8" ' For PPT97: hwnd = Find Window("PP97Frame Class", 0&) Case "9" ' For PPT2K: hwnd = Find Window("PP9Frame Class", 0&) Case "10" ' For XP: hwnd = Find Window("PP10Frame Class", 0&) Case "11" ' For 2003: hwnd = Find Window("PP11Frame Class", 0&) Case "12" ' For 2007: hwnd = Find Window("PP12Frame Class", 0&) Case "14" ' For 2010: hwnd = Find Window("PPTFrame Class", 0&) Case "15" ' For 2013: hwnd = Find Window("PPTFrame Class", 0&) Case Else Err.Raise Number:=vb Object Error ERR_VERSION_NOT_SUPPORTED, _ Description:="Newer version." Exit Property End Select If hwnd = 0 Then Err.Raise Number:=vb Object Error ERR_NO_WINDOW_HANDLE, _ Description:="Unable to get the Power Point Window handle" Exit Property End If If Lock Window Update(hwnd) = 0 Then Err.
Raise Number:=vb Object Error ERR_WINDOW_LOCK_FAIL, _ Description:="Unable to set a Power Point window lock" Exit Property End If Else ' Unlock the Window to refresh Lock Window Update (0&) Update Window (hwnd) hwnd = 0 End If End Property 'Sample Usage: Sub Long Processing Sub() ' Lock screen redraw Screen Updating=False ' --- Long time consuming code ' Redraw screen again Screen Updating=True ' Also see below article for another example of usage of the code End Sub It's fairly simple to open a Power Point file (*.ppt) for editing using VBA code however opening a Power Point Show (*.pps) file for editing is altogether another matter. Open method and it defaults to open the file in Slide Show mode. The routine below illustrates a manner of woring around the default behaviour and opening the file for editing.
Excel & Word have the Screen Updating method thru which a developer can lock the main window from unnecessarily redrawing itself whilst the macro is being executed. If left alone, redrawing is not only ugly on the eyes it also takes more time for the macro to reach completion.
Manually, I enter the following formula: =VLOOKUP(K2,'C:\Users\me\Documents\raw data\[current products to analyse.xlsx]Sheet1'! Thus, I can then autofill down my sheet to calculate for many rows.
I've tried the following: Sub check_for_analysis() Dim result As Variant ' check_for_analysis Macro ' check_for_analysis using the VLOOKUP to external file Range("P1").
Hey everyone, Have tried to gather information from other sources, but to little avail - When clicking the button on my userform, it goes through a quite complex process of changing the views in several pivot tables that are linked to an "report" sheet, which has all the figures the user needs in a neat format.


text:
Bungin Jaya is een bestuurslaag in het regentschap Ogan Komering Ulu van de provincie Zuid-Sumatra, Indonesië. Bungin Jaya telt 775 inwoners (volkstelling 2010).

Plaats in Zuid-Sumatra

redpajama_set_name: RedPajamaWikipedia


I believe one of the key personal qualities an individual can offer to as Business Development Professional is drive and enthusiasm. as Business Development Professional traits to me need to withstand rejections be customer focused, career driven, passion for sales, ability to delight customers through relationship building above all abilityto listen, put myself in customer situation and come up with appropriate solution and I am able to stay motivated even when dealing with very difficult customers.
My continuous employment in the business development and account management over 6 years and my application to bettering myself through self initiated training demonstrated my willingness to "go the extra mile".
Following over 6 years in mixture of retail, business to business and call centre type of business development and account management environment (experience in both dealing with customer face to face as well as over the phone) I find myself ready to take on new challenge and am highly motivated to undertake any challenge ahead of me.
Manages and grows new customer relationships and revenue associated with the company IT security software and networking products.
Qualifying new accounts and making sales of strategic vendor products.
Establish, develop and maintain strong professional sales relationships with current and future Channel Partners.
Create and analyse sales reports, identify issues contributing to success or shortcomings and take any corrective action.
Support and leverage other channel efforts, field marketing, product launches and product promotions as well as certifications and specializations.
Keep current with our product release information including sales materials, product roadmap, features, applications, competition and disseminate to partners as appropriate.
Recruit new channel partners and channel partner sales and process training and continued achievement of Channel Partner sales growth.
Perform business metrics reviews and analysis of each Channel Partner's performance.
Takes initiative in getting necessary training and certification on vendor products.
Monitors client satisfaction and elevates issues of dissatisfaction for quick resolution.
Sets own priorities and schedules to meet established goals; meets commitments consistently.
Drives Revenue through recognition and realization of opportunity with existing accounts by up selling and cross selling other energy product.
Meets and exceeds weekly target by executing an account growth strategy.
Work with customers and to leverage solar PV product and services to enhance customer's business and grow customer portfolio opportunities.
Manages relationships with customer as the primary point-of-contact for day-to-day issues, including ongoing communications, and coordination of installation project, billing and other activities to ensure continued customer satisfaction.
Regularly review customer experience and provide these feedbacks to assist the company in modify process where necessary to satisfy customer expectation.
Target for sale was two sales per day have managed from one to two sales per week to average 2 - 5 sales per day.
Best sales per day was 5 sales, best week was 15 sales per week.
Relationship Skills In a recent customer feedback survey at TRUenergy my customers praised my outgoing and friendly disposition, and especially my willingness to spend that extra bit of time with them getting to understand their needs. Over the years of sale I have developed a loyal customer base who now constitute over 50% of my (repeat) business in all industry I been working in. Motivation I am keen to learn new ideas and skills; often I go to book shop to read book on business development to better myself and motivation book to keep me going. Another key to better my skills is to have good conversation with experience people and learn from them in all aspect of life and business. In my job in business development professional I establish goals for myself, setting higher standard to better myself resulting in me having one of highest tribute from customers hence, resulting in generating more business for the company over 6 years. Language Skills Can speak and write fluent Chinese – Mandarin Computer Skills · Knowing office package: Microsoft Words, Microsoft Excel, Microsoft PowerPoint and Microsoft Outlook Express · Other software: Lotus Notes and SAP Other Relevant Skill Account Management and Business Development Skill · Ability in managing multiple projects and priorities with attention to quality, detail and results · Contribute positively to the team environment · Produce high impact proposals, reports and communications · Maintain a high level "cutting edge" knowledge and awareness of the key business drivers for clients · Sales experience and exposure to digital marketing including SEO, PPC and some SEM and Social Media (Facebook, Twitter & LinkedIn) · Demonstrate flexibility and agility to manage accounts at different stages of maturity · Employ a systematic approach to analysing territory and account potential to prioritise and focus Sales activity · Flexibility to work in an evolving dynamic and fast-paced work environment · An ability to be a good team player · A strong customer service ethic and drive towards the achievement of optimal customer experience outcomes.


Our Developers and Sales Team struggle with our bottom line pricing. There are thousands of businesses that simply don't have the resources to spend $10,000 on a website. Our Account Managers talk to these people everyday. We want to help these businesses develop their presence on the internet, but we also want them to have quality websites that serve them well. It's not always easy to do that on a very tight budget.
Design and development of websites takes time and money. The cheapest solutions, like the cookie cutter websites advertised on TV, just don't cut it in today's competitive world. Websites need to project a professional appearance. Functionality and SEO aren't options with the cookie cutter sites. That leaves us with either a templated design or a custom website design.
Unique image exclusive to your business and brand.
Functionality is built to do exactly what you need. Also allow for easier addition of functionality down the road.
Coded for optimal SEO and ease of administration.
Templated designs can potentially offer cost savings of $4,000-$6,000 because they use pre-built functionality and visual designs. Although a templated design might save money off the top, is it actually cost effective? The short answer is no.
Ease of use-- the template is going to have some areas where changes will require so much time/code changes that it will negate the cost savings.
May not be able to easily change a particular functionality, or may not be able to automate a function that is easily automated in a custom design.
Not coded for SEO-- difficult if not impossible from a cost-effectiveness standpoint.
Can be used by multiple users-- so your competition may have a website that looks just like yours. Even if you purchase exclusive rights, anyone who has previously purchased that template can and will still use it.
These are all some of the areas that make custom sites a much better option long term. Templated sites aren't a great alternative, but they are a better than a cookie-cutter site.
When it comes to investing in your website, think about how it sits from a long term perspective. Make sure that you weigh the benefits over the costs at all levels. Don't be afraid to ask questions about how cost saving measures in the short-run impact the overall value of your site, it's longevity, and effectiveness.


The dragon fruit is a strange little fruit hailing from Southeast Asia and Central America, although the cactus that produces the fruit is originally from Mexico. The fruit is shaped like a grenade and is covered in what resembles "dragon scales", if ever dragons did exist. On the inside the fruit can have white, yellow or a deep pink flesh, while the skin on the other hand is usually a fuchsia color.
Dragon fruits are surprisingly high in nutrients. This fruit can contain up to 10% of your daily requirement for vitamin C. The fruit contains several B-vitamins and is even a good source of calcium.
If you want more anti-oxidants in your fruit, pick the ones with the deep pink flesh.
The pigment that causes the color is lycopene – an anti-oxidant that has been found to fight certain types of cancers. Even the tiny black seeds contain omega-3 and omega-6 fatty acids. Despite being so highly nutritious, dragon fruits are pretty low calorie fruits that are also low in sugar making them ideal snacks for those who are trying to manage their diabetes.
Berries are amazing. They are probably nature's first portable multi-vitamin. It's amazing how much benefit we can get from such a small package. Where else can you find a kind of food that helps you fend of cancer, dementia and the common cold that is both yummy and super low calorie.
There is evidence which shows that eating a serving of blueberries and strawberries every week can help delay cognitive decline for up to two and a half years. This is attributed to compounds in the berries called anthocyanidins which cross the blood brain barrier to provide nutrition to learning and memory centers in the brain. Berries are also rich in flavonoids and these compounds have been found to reduce the risk of developing Parkinson's disease by 40%. To top it all off, berries lower blood pressure as well as promote cardiovascular health.
Bet you never thought of avocado as a great summer treat, but it is! Traditionally used for savory applications this rich and creamy fruit can be made into ice cream, nice-cream (more on that later!) popsicles and creamy fruit shakes.
A pear shaped fruit with alligator like skin and creamy flesh, the avocado is rich in vitamin E and K, vitamins B5 and B6, vitamin C and potassium. Avocado even has more potassium than bananas!
Seventy seven percent of the calories in avocado are from fat. Good thing it's good fat, mostly heart-healthy monounsaturated fatty acids. It is rich in oleic acids, the same component that makes olive oil so healthy.
Okay, let's talk about avocado NICE-cream as promised. Most of the nice-cream recipes we see online are made out of bananas but the inherent creaminess of avocados makes them a perfect swap for any of the ice cream cones you can get at any ol' ice cream truck.
To make avocado nice-cream simply take 2 ripe avocadoes, 1 ½ cup of milk, 1 cup of cream, ½ cup of sugar and blend in a blender until smooth. Pour into an ice cream maker and wait for it to set.
Papayas, with their sweet juiciness and sunshine-y color, remind us a lot of the tropics and the warm heat of the summer. Once quite exotic and referred to as the "fruit of the angels", this fruit is now available year round.
Papayas are very nutritious fruits – they are filled with vitamin A and beta carotene (as you can see from their orange flesh), vitamin C, potassium, flavonoids and papain.
The vitamins A and C in papayas are particularly important in fighting atherosclerosis. Plaque develops through the oxidation of cholesterol and these vitamins prevent it from happening, essentially preventing atherosclerosis.
Papain, a proteolytic enzyme found in plants is particularly abundant in papayas. This enzyme has been found to reduce inflammation (by breaking down proteins that cause inflammatory responses) and is also effective in treating burns, possibly by hastening the breakdown of burnt and dead tissue, preventing infection from cell necrosis.
Get a serving of papaya by eating it by itself or with a squeeze of lime. You can also add both ripe and unripe papaya (which has even MORE papain) to salads.


Velotopia is as circular as the topography has allowed, for the usual reason that citizens are always clamouring to live near the civic centre.
Development has been restricted to level ground and city limits have been restricted to a diameter of 15km. That ensures average commuting distances of less than 7km and average trip times of less than 30 minutes by bike.
The 15km limits define an area of 177 sq km. Development control guidelines are designed to ensure that at least 30,000 people live in every square kilometre, the average density across Manhattan (including the parks).
Velotopia has never sought the services of mobility experts, so has no P&R (park and ride), ERP (electronic road pricing), PRT (personal rapid transport), HOV lanes (high-occupancy vehicle), LRT systems (light rail transit), or anything else that might seem essential because it is described by an acronym. In fact, it is completely car-free. Velotopia has a ground plane where nothing is allowed to threaten or obstruct cycling.
Whenever stakeholder groups are formed for consultation on matters of planning or public life, their constitution requires that the majority be parents of young children. There is no charity or positive discrimination at play here. They simply want to optimise conditions for a group that makes many trips in a day and whose work – raising the next generation – has a great influence on the city's wealth and productivity in the long term.
Successive committees of parents have voted against a rail network throughout the city. It is sufficient, they have said, to have a few solar-powered electric carts available to collect them at times when they are physically unable to cycle.
Velotopia has a small but efficient fleet of these electric carts.They are limited to 15 kph to ensure they always fall in behind bicycle traffic. Nevertheless, they benefit from the city's smooth flow. They never have to slow down or stop, so the connectivity speed is much faster.
The city doesn't need traffic lights as there is no risk of high-speed collisions. Instead there are small roundabouts, raised on elevated mounds. Rising on to the mounds, bikes naturally shed enough speed to safely filter through, before regaining their lost speed as they descend.
There is a major subway station in the centre of the city, covered with ground level shops. Above those is a giant structure for parking thousands of bikes. But trains departing this station don't leave to other parts of the city. There is no local network. No metro map can be seen on its walls. All of the trains that depart from Velotopia Station are bound for other cities.
Dotted around Velotopia, outside city limits, are car parking garages. Visitors coming from car-centric parts of the region park their cars here and swap to one of the four legal modes – cycling, walking, pedicabs or the dynamically-routed driverless carts – to enter the city. Although most Velotopians heading out of the city go on their bikes, some hire cars from these points on the outskirts if they need to go to the country.
With regards to essential services, non-urgent patient transport is done with modified pedicabs and police do patrols using bikes. Cargo bikes are used for deliveries to houses and small shops, and tradespeople, cleaning contractors, gardeners and other groups who can't prove they need to carry more than 500kg for their work are likewise compelled to use them.
As a result, and even though it is a city of millions, there are never more than a few dozen heavy vehicles moving throughout Velotopia at any one time – not enough to warrant a network of service roads. Successive committees of stakeholders have been very particular about not wanting service roads. People here don't want to be superficially car-free while cars serve their needs in some behind-the- scenes way. They say that would be like living on Main Street, USA, in Disneyland where visitors are led to believe there are no vehicles, rubbish collections or hurried staff, and that all of the shops are somehow stocked using magic. Disneyland's deceit is only possible thanks to an underground network of utility corridors.
The people of Velotopia know that garbage trucks collect their bulk waste. They see the cranes and cement mixers that build their new buildings. They are aware that trucks service their supermarkets. It is precisely because motorised vehicles are put in plain view, where they sometimes annoy them, that the people of Velotopia would never vote for a mayor who allowed the ration of motorised vehicles to ever increase.
That leaves fire trucks, ambulances and police cars. These all have 15-kph speed-limiting devices just as the trucks do, but can move at full speed under siren. Emergency vehicles make better time than they would in a city of cars thanks to Velotopia's compactness and the ease with which cyclists are able to get out of their way.
In Velotopia every commercial premises has a corner location. It is as if one day all the disgruntled shopkeepers lining the avenues had picked up their shops, relocated them part-way along their nearest side streets, then finished their day by quadrupling the number of avenues.
Overall numbers of passers-by are even higher for shopkeepers here than on avenues in Manhattan. That's because moving in this city is fun. People make more discretionary trips. Half of the time they're moving through the city for no reason other than to be out. For merchants it's like having a kiosk in the middle of an ice rink with prospective patrons randomly swirling around them. Every patron has between 10 and 15 seconds to notice their shop, travelling at between 4 and 5 m per second.
From the point of view of citizens riding their bikes, it is a great relief not being herded to avenues and funnelled along them.
This may sound like a difficult city to find your way around, but the ground plane of Velotopia is infinitely varied. Cities with cars may be diverse in their architectural forms and the widths of their streets. Look down, though, and all you will see is the same tired asphalt, curbs and lane markings. In Velotopia there are smooth tracks that attract skaters, dirt tracks with berms and jumps designed for mountain bike riders and more paving treatments than you could fit in a catalogue.
The shops all sit on top of earth mounds so that cyclists naturally slow down as they approach them, and naturally speed up as they ride away. There is a saying here that high means slow, and low means go. High points are where bikes slow to a speed suitable for mingling with pedestrians, while the low spaces between are for bikes to move at cruising speed.
So how do pedestrians move between shops? In parts of Velotopia that have turned out to be busier because of a conglomeration of popular attractions, the preference is for grade separation. Lightweight bridges link the crests of the mounds so pedestrians can walk over while cyclists ride underneath. The few bridges that require them have lifting mechanisms to allow heavy vehicles to pass under. Throughout most of Velotopia, though, cyclists and pedestrians convivially share the same space.
• Dr Steven Fleming is the founder and director of Cycle Space, a consultancy helping cities around the world with bike-centric architecture and urban planning approaches. He can be found on Twitter at @behoovingmoving.
Velotopia is published by nai010 Publishers, who specialise in publishing and distributing books in the field of architecture, urbanism, art, and design. Physical and electronic copies can be ordered from their website.


Filmed in Greenfield, Indianapolis, and rural Rush County, Indiana in 1987 and premiered in 1988, "Pushed Too Far" stars Indiana native and veteran actor Claude Akins and 3 time USKA World Karate Champion Herb Johnson. This is a 1st Release Collector's Edition of the movie on DVD with color photograph on the DVD. A story of action and drama, a small peaceful community faces danger when a deranged professional wrestler stalks its citizens...and finally the local karate school owner. His non-violent teachings won't allow him to seek revenge, but when his family becomes the target, he is faced with the toughest decision of his life. No one knows what a man will do until he's...PUSHED TOO FAR! Rated PG Color/95 minutes. English version only. Not closed captioned.
The film received theatrical distribution in the United States and was released on VHS tape through Major Video Concepts and Waxworks to video rental stores throughout the country. The film also received foreign theatrical sales. The DVD for sale on this site was specifically manufactured as a "limited edition collector's copy" as a promotional fund raising event for the restoration of an old movie theater in Greenfield, Indiana. All rights including television and DVD licensing rights for the film are available!
About CLAUDE AKINS: Akins was raised and worked in Bedford, Indiana where his father was a policeman. He became best known in the 70's for his television roles as Sonny Pruit in "Movin' On" and as Sheriff Elroy P. Lobo in "BJ and the Bear" and the spin-off "Lobo." He appeared in more than 50 movies and 400 TV shows. His film career included roles in the Academy Award-winning film "From Here to Eternity", "The Cain Mutiny", "Inherit the Wind", "How the West Was Won", "The Devil's Brigade", and in 1992 in John Mellencamp's movie, "Falling From Grace."
Herb Johnson, 66, passed at home on Friday, November 20th, 2015. Herb and his wife shared 34 years of marriage together. He was the father to two children.
Herb was born in Kentucky on March 25th, 1949 to Truman and Flora Johnson. He is predeceased by his parents, Truman and Flora Johnson and sister, Carol Johnson.
He is survived by his wife, son, daughter, grand-daughter, and three brothers. He is also survived by several nieces, nephews and cousins.
Herb began his Martial Arts training career as a high school wrestler. After high school, he went to Ball State University, where he met Bill Wallace. This is where Mr. Johnson was introduced to Shorin Ryu Karate. After he left Indiana, Mr. Johnson trained with Glenn Keeney in Goju Ryu Karate. In 1973, Bill Wallace returned to Indiana and opened Olympic Karate Studio of Indianapolis which was owned by Ken Knudson of Chicago.
In 1974, Bill Wallace left to begin training with Elvis Presley and Mr. Johnson took over for Bill Wallace and began working for Ken Knudson. In 1977, Herb purchased the Olympic Karate Studio of Indianapolis. Soon after, Herb began training with Robert Trias and was later named Style Head of Shorei Goju Ryu in 1979.
Herb had a tremendous amount of love and joy for his family and karate students. He enjoyed taking rides on his Harley Davidson and was an avid bass fisherman. He enjoyed hunting with his father, uncle and brothers when he was younger. He enjoyed dates with his wife at the home Colts games. Herb loved spending time with his family including taking his grand-daughter on four wheeler rides through the woods.
A gathering of friends will be from 5 to 7 p.m. Tuesday, December 1, 2015 at the Greenfield Church of God, 1561 E. Main St. in Greenfield, for those who wish to convey their condolences.
A Celebration of Herb's Life will be at 7 p.m. Tuesday at the church.
Copyright 1988 John Kleiman and Kelly Hocker. 2018 All rights reserved.


We keep your vehicle running at peak performance levels and ensure there are no issues that could cause you problems in the future. Our experienced technicians and certified master mechanic provide every vehicle with a 15-point inspection.
Having regular preventative maintenance done on your vehicle is necessary if you want to keep it in good working order. Regularly having an oil change helps keep your car running smoothly for much longer. Without regular maintenance, you will almost certainly end up suffering from a costly breakdown. Keep in control and regularly maintain your vehicle. You get to choose when your car goes in for maintenance but not when it has to go in for repairs.
Here at Uncle Al's Quick Lube & Wash, we hire only the best. Our expert technicians follow the specifications set by your car manufacturer to ensure everything is working as it should be. We have the best technology available that allows us to quickly and effectively diagnose almost any issue that you might have with your vehicle. Just schedule an appointment with us and we take care of the rest. Your car will be up and running the way it should in no time.
If you are ready to try the preventative maintenance services offered by us here at Uncle Al's Quick Lube & Wash, just give us a call! We'll fit you in at a time convenient to you. Not only will we give your vehicle all of the necessary oil/filter changes, but we also do a thorough assessment to identify any issues with your vehicle. This means that you will avoid the stress, inconvenience, and expense of a bad breakdown in the future.


text:
Nuffield Scholarship program an opportunity for farmers.
Member for Warren-Blackwood, Terry Redman is encouraging future leaders in the agricultural industry to apply for the 2018 Nuffield Scholarship program.
Mr Redman said the awards afforded primary producers scholarships to research a topic that would add value to the Australian agricultural industry by supporting their overseas travel and study.
"The Nuffield Scholarship program has proven to be a launching pad for scholars from Australia and across the world who are passionate about growth and innovation in the agricultural sector," Mr Redman said.
"The program has enabled scholars to make a significant impact at a regional and local level, both in their communities and in farm management."
Mr Redman said Warren-Blackwood boasted many talented and passionate agricultural professionals and noted the opportunities that often arose from participating in the program.
"Scholars produce a written report and communicate their knowledge and experience to others in the industry," Mr Redman said.
"This knowledge builds the capacity of industry, enabling farmers and agriculture professionals to remain competitive in an ever changing global landscape.
"Ongoing communication, networking and events with fellow Nuffield scholars ensures the learning experience continues even after their participation in the program concludes."
Applications for the 2018 program close June 16, 2017.
For more information visit: http://nuffield.com.au/scholarships/

redpajama_set_name: RedPajamaCommonCrawl


text:
TABOR vs. Colorado's floods
Colorado floods, tabor, Taxpayer's Bill of Rights
This Oct. 25, 2013, photo shows flood debris that smashed into and heavily damaged the town hall and general store in Glen Haven, Colo., during heavy flooding in September. (AP Photo/The Coloradoan, Kevin Duggan)
Re: "Colorado voters were saved by TABOR," Nov. 25 guest commentary (online only).
When the Taxpayer's Bill of Rights was approved more than 20 years ago, I am certain not one voter contemplated what effects the measure would have on dealing with a major flood such as the one that covered more than 1,500 square miles of northeast Colorado earlier this year.
TABOR restricts the kinds of taxes which can be levied during an emergency. It restricts what must be kept as emergency reserves. It prevents holding an election immediately when a flood occurs to raise the revenues needed to address any damage. It penalizes local governments receiving certain grants in an emergency.
The most important tool needed by local governments when faced with a disaster is ready access to the resources necessary to protect the health and safety of citizens. Natural disasters are not planned in advance and when they happen citizens expect the most and best from their local government leaders, not the least and the worst.
Sam Mamet, Denver
The writer is executive director of the Colorado Municipal League.
This letter was published in the Dec. 2 edition.
For information on how to send a letter to the editor, click here. Follow eLetters on Twitter to receive updates about new letters to the editor when they're posted.
Schools and Christian charities
Going nuclear on Senate filibuster rule (5 letters)


text:
ISIS - The New Threat To World Peace?
ISIS Flag (Photo Credit: By Yo - Own work, Public Domain, https://commons.wikimedia.org.
On the eve of the 13th anniversary of the September 11th, 2001, terrorist attacks, President Obama declared a new war on terror. However this time his target was not our age-old enemy al Qaeda, but a group that goes by one of three acronyms: ISIS (Islamic State of Iraq and al-Sham), ISIL (Islamic State of Iraq and the Levant ), or simply, IS (Islamic State). So who is this new terrorist organization that has the world on edge? Read on . . .
The genesis of this jihadist group can be traced back to 2011. Similar to many other countries in the area, Syria was experiencing what is now being collectively called "Arab Spring" - A series of revolutions that began in the North African country of Tunisia and spread to the neighboring countries of Egypt, Algeria, Yemen and many others. While a majority of the leaders gave in to the wishes of their people and resigned, Syrian President Bashar al Assad managed to quell the uprising. Since then, the country has been embroiled in a civil war with several rebel groups still trying to overthrow the President. Among them, is Jabhat-Al Nusra, an "approved" offshoot of Islamic militant group, al-Qaeda.
Though the group was radical, they did not garner much world attention until April 2013, when the "Islamic State of Iraq" another offshoot of al Qaeda led by Abu Bakr al Baghdadi, decided to join forces with Jabhat-Al Nusra. When both al Qaeda and the leader of Jabhat-Al-Nusra protested against the union, Baghdadi convinced 80% of the Syrian rebel group's members to defect with him and form a new organization that he called the Islamic State of Iraq and al-Sham (ISIS).
Photo Credit: U.S. Department of Defense, September 2015
The term "al Sham" refers to a vast area that includes southern Turkey, Syria, Egypt, Lebanon, Israel and the Palestinian territories. Baghdadi plans to conquer all and unite them as one Islamic state or Caliphate. Since the English term for this entire region is "the Levant", many experts and politicians have begun to refer to the organization as the Islamic State of Iraq and the Levant or ISIL.
No matter what they are called, the one thing that is rapidly becoming apparent is that the organization, which has broken all ties with its parent group al Qaeda, means business. Since their formation, ISIS has rapidly expanded its control over towns and cities in Syria and Iraq. What's even more disconcerting is that their growth has been strategically planned around areas that are close to major supply routes, crucial infrastructure and important border crossings.
As a result, they are able to smuggle goods as well as oil from the 11 fields that are now in their control, and sell them at highly discounted prices to help fund their terrorist activities. Experts estimate that this together with extortion money obtained from kidnapping foreign nationals for ransom, as well as widespread looting of old artifacts, yields the group about $3 million USD daily. If the estimates are correct, it elevates ISIS into the world's wealthiest terrorist group, making them even more lethal.
Yazdi refugees receiving support from the International Rescue Committee (Photo Credit: DFID - UK Department for International Development (picture: Rachel Unkovic/International Rescue Committee via creativecommons.org
In addition to inching towards the formation of the dream 'Islamic State', ISIS has lately also been grabbing headlines with the public beheadings of two American journalists - James Foley and Steven Sotloff, as well as British aid worker David Haines. Some officials believe the videos, which have been distributed worldwide, are a way to warn off the group's foes, particularly the US military, that has been able to stop their progress towards northern Iraq. Others think it may be for just the opposite reason - to draw the world's ire and force them to declare war against the terrorists.
If that was their intention, it certainly seems to have worked since the US along with 40 allies have vowed to do whatever is necessary to fight the group of approximately 31,500 rebels that are causing havoc worldwide. While the current plans are to try weaken the group by using drones and reconnaissance flights to strike down crucial check posts and vehicles believed to be transporting key personnel, some experts fear it may not be enough. They think that the only way to defeat this increasingly sophisticated group of militants, is by deploying ground troops. If they are right, the allies may be drawn into another long-drawn war, a situation that everyone hopes to avoid, unless it becomes inevitable.
Resources: theguardian.com,independent.co.uk, telegraph.co.uk, wikipedia.org, vox.com
Dolasia, Meera. "ISIS - The New Threat To World Peace?." DOGOnews, DOGO Media, Inc., 21 Sep, 2014, www.dogonews.com/2014/9/21/isis-the-new-threat-to-world-peace. Accessed 29 Jan. 2023.
Dolasia, Meera. "ISIS - The New Threat To World Peace?." DOGOnews, DOGO Media, Inc., 21 Sep, 2014, Web. 29 Jan. 2023.
Dolasia, M. (2014, September 21). ISIS - The New Threat To World Peace?. Retrieved 2023, January 29, from https://www.dogonews.com/2014/9/21/isis-the-new-threat-to-world-peace
Dolasia, Meera. "ISIS - The New Threat To World Peace?." DOGOnews. September 21, 2014. Accessed January 29, 2023. https://www.dogonews.com/2014/9/21/isis-the-new-threat-to-world-peace.
AlgeriaEgyptIsraelLebanonSyriaTunisiaTurkeyYemen
bboos3000over 1 year
Why is ISIS a thing, just why?!
x_goddess_xover 1 year
It's really dangerous, and scary. It try not to think about it all the time.
master1over 1 year
ISIS is horribley and they are in the future gonna join the Taliban and Be the most powerful militant group in the world i think
generaldruid51almost 2 years
ISIS will regret this eventually.
fudge77about 2 years
solana1344over 3 years
stop killing people that do nothing to you
RobotFaxMachineover 3 years
ISIS is super bad and it must be stopped by all the countries.
Magpiealmost 4 years
Stop it ISIS I don't know why you kill but stop!😤
So sad...
I live in Tunisia and all the people are scared of ISIS just like us. Some people think all arabs are bad but they are not. Also I speak Arabic so I can read the tag it say "La Ilah Ila Allah" "Allah Rasoul Mouhammed" which means: There's no God except God and Mouhammed is God's messenger.
duskyalmost 3 years
Very true my friend I also live in a all muslim country and some of the fighters originate from here (Maldives) but our respected President is getting rid of the fighters. The fighters are not really Muslim they pretend to be so
ditooI we oSaIcdm SHu?b
ifu oWtodt?Ssss S a h amidi?eihewnttsIes'r uHiotg voisncipsI
ppa ciireatlnotegwtneare ue soap rl osHoitlncw W trdp teechtdstkun?hiw'' tieaag seachns fe?onhcsverdai id
somrycantaftcriascdtefeoplyedgniegditnrcosncireldmieoboxneoittrefosseniegshocavbilteneivariftrutuscnareeriiadijthshatlelhoftosofeesnlopnrqulelcaaidlranrsmoincensaserocnaironuvesloteyisaaltgctrlnpiuisgr


A view of the European Parliament, Brussels.
During the signature ceremony of the declaration, Luca Jahier, President of the EESC, stated: "Understanding and embracing change will allow Europe to move forward and shape the global order for the 21st century. There is no other alternative than being together. There is no way back. I am very happy to work together with President Tajani to reassert the moral foundations of our model of democracy. ThisTimeImVoting yes, but for us at the EESC it's also ThisTimeImActing".
" The European Parliament is committed to responding to the needs and priorities of citizens – especially on jobs, growth, security, migration and climate change. We all have a stake in these elections and we have a duty to inform. The EESC can play a key role in engaging social partners and wider civil society in this election campaign that will determine the future of Europe," underlined Antonio Tajani, President of the European Parliament.
The joint declaration signed by President Jahier and President Tajani points out "the need to anticipate, act and react with proper facts to annihilate fake news and make sure the positive and true stories are not overshadowed by negative, opportunistic propaganda". With this aim, the EESC and the European Parliament will undertake a number of activities in order to raise awareness of civil society organisations and the general public about the upcoming European elections and to encourage participation.
General communication: 3 major awareness campaigns will be run through to encourage EESC members to play an active role in the European elections' campaign. They will also be asked to act as ambassadors towards their respective organisations and will receive specific training for Going Local actions in the context of the elections. A special attention will be paid on how to communicate on social media, with specific guidelines on the use of hashtags, target groups, etc. and an internal training event for EESC members and staff.
Events and conferences: all major activities organised by the EESC or taking place in its premises will include awareness raising on the elections, in particular the EESC Citizens' Convention that will be organised in Brussels in early 2019. EESC members will also be encouraged to organise Going Local activities linked to the elections with the help of the EP information offices and to interact with lead candidates (Spietzenkandidaten) whenever possible. The "Europe Day" on 4 May 2019 will also focus on the European election, with specific activities.
European Parliament election will be held in 23–26 May 2019.


When a faulty time machine deposits Diego at the top of a pine tree, he knows he's in the wrong place – but has no idea he's in the wrong time. Naked and shivering in the chilly mountain air, he attempts to climb down, but slips, whacks his head, and falls into oblivion. He wakes up inside a darkened room, crippled and disheartened, and must come to grips with the realization that he is marooned in a bleak alternate future. In this universe, what remains of the human race is trapped inside a handful of aging biodomes. With his mission failed, his world destroyed, and the one woman he loves dead, he can find no reason to go on living. But Lani, the emotionally scarred doctor who finds him, refuses to let him give up, and as Diego heals, their relationship becomes complicated. He struggles to let go of the past, but is unable to get Isabel out of his head or his heart. Just when it seems he may be able to find some measure of happiness in a world teetering on the edge of extinction, another note arrives from the future: Isabel is alive – but not for long.
This is book two in the series and follows Diego's journey into the future, but in a different timeline. When he opens his eyes and finds himself up the top of tree. In a snow-covered habitat, that's all he sees before he falls and breaks multiple bones.
Luckily he is rescued, and wakes up in a Bio dome being looked after by a doctor called Lani. It was then when he realised he is twenty years in the future.
This is a shorter book than the first, but no less interesting. We are twenty years after D day and the human plague that has driven everyone that survived in to domes, and humans can't be outside without bio suits. In the Dome Diego is taken to, everyone is friendly and the children are so innocent.
Diego takes nearly a year to recover from is injuries, and still can't stop his love for Isabel which controls his actions.
Diego soon finds out not everyone in this world is warm and friendly. This a shorter listen, but no less enthralling as we learn more about this world.
I can't praise the narrators enough, it was like listening to a large cast of characters, and that is amazing when you realise there is only two.


text:
Bringing Psychology to Cyber Security
Stories of cyber security breaches have become are a regular occurrence in the media. Companies have banks have been scammed out of money; customer details have been stolen from phone companies and credit agencies; the NHS was forced to cancel and postpone procedures following the Wannacry incident. Even the largest and most capable technology companies such as Google and Facebook have fallen victim to hackers. There has been a corresponding response from academia and law enforcement, with the creation of the National Cyber Security Centre in 2016 and the growing number of cyber security courses offered by universities and industry. These real-life events have been mirrored in an increasing public interest in the hacking and hackers, illustrated by the popularity of such TV shows as Mr Robot.
Given the technological nature of cyber security it can be easy to forget the role of people in cyber security, but every cyber security only occurs because of a serious of decisions and actions by individuals. Many cyber security attacks rely on tricking a target in some way; such as through opening a malicious link or divulging sensitive information. The attackers themselves may have complex motives for selecting and pursuing targets – the stereotype of the hoodie wearing hacker seeking to steal credit card numbers is an over-simplification. In case of hacktivism individuals may make use of hacking skills to challenge social injustice or oppressive regimes. Many of those who may be labelled hackers work for the benefit of society by identifying vulnerabilities in computer system and reporting these problems to the organisations and companies involved.
Dr John McAlaney, Associate Professor Jacqui Taylor and PhD researcher Helen Thackray of the Department of Psychology work alongside colleagues in the Bournemouth University Cyber Security Research Group to understand the people behind the computer screens. This aims to include all of those who have a stake in cyber security – the public, the cyber security practitioners and those who seek to identify, and in some cases exploit, the weaknesses in computer systems. An example of this is the work currently being undertaken in researching the social identity and group dynamics of hackers and hacktivists. This is done through spending time with on relevant web forums, conducting interview online and visiting events such as the DEF CON hacking conference, attended every year by approximately 20,000 people in Las Vegas. This work has already produced some novel insights into how people involved in hacking communities share knowledge and skills to overcome substantial technological and societal challenges.
Dr John McAlaney and colleagues work together to bring these research ideas to the public, industry and government. In November 2017 he spoke about the role of psychology in cyber security at an event hosted by the Foreign and Commonwealth Office at the University of Manchester, which was attended by industry and government officials from several Gulf countries. This was followed by a trip in December 2017 to speak at the 'Realigning Cyber Security Education' event hosted by the Australian Defence Force Academy to discuss how to incorporate psychology into the education of the next generation of cyber security practitioners. Future work will continue to explore how psychology can be used to address the challenges in cyber security that technology alone cannot.
Fire alarm testing across BU
Please be aware that the fire alarm sounders will be tested between 6am-8am over the next few weeks.
SportBU: sign up for Campus Sport activities
Start your New Year's resolution and get fit with these great offers from SportBU!
Get exam ready!
READ: Tips for revision techniques, managing stress and where you can revise or study on campus.
BBC Radio 4's The 3rd degree quiz show
Join us to watch BU staff and students battle it out in a live recording of Radio 4 quiz show The 3rd Degree.


First, that's a lovely cover. Just wanted to say that, because once again that's what caught my eye while randomly browsing for a distraction. Now for the review.
The book is told in first person, alternating chapter-by-chapter between the voices of Audrey and Aaron, which actually works well. Sometimes I had to check back to see who we were following, but I think that was about me being tired, not the voices being clear (actually, the voices aren't so very different, but the things they notice and comment on are, if that makes any sense). We start with several chapters of the kids' lives at home, which sets the backstory for why they are going on the wilderness camp and why each struggles with friendship. Of course, knowing that, we know from the start that the two will become friends during this camp experience. And we know that the wilderness camp will test them in unexpected ways.
The story lies in how those things happen. The one drawback, for me, is that the story relies in part on an unbelievable setup for the wilderness trek. The idea that any commercial operation could or would take 15 kids into the desert with only one adult was almost laughable (but probably wouldn't trouble juvenile readers). That adult then exercises a lot of bad judgement and endangers his charges more than once, which is also probably more believable to young readers. For a time, however, the unbelievable elements made me think I might not be able to enjoy the book. And the book does rather depend on there being just the one adult present.
Fortunately, as the kids begin to bond and discover their strengths and overcome their weaknesses, I was more able to engage in the story. I liked that Aaron and Audrey aren't "troubled youths," in the typical sense. This isn't a camp meant to whip kids into shape before they end up in jail. It's "La Viaje a la Confianza," the Journey to Confidence, and while some of the kids are dealing with some major issues, those issues aren't trouble with the law.
And even though things don't exactly go according to plan, they do gain confidence. Audrey and Aaron also come to realize that they can learn to live with their issues, be honest with each other (and the other two friends who are part of what becomes a foursome), and be best friends anyway. In the end, this gets a positive review despite the unrealistic elements, because the message is great without being preached at the reader. Instead, it is wrapped in a mild adventure. The ending gives it a bit of a marking down, for excessive sentiment.
I think this is a good read for any kid who wonders if he or she has what it takes to have friends (which I'm guessing is most junior high kids). But beware: whether or not the reader already loves the outdoors, they are apt to feel at the end as though they could maybe love the desert, and they'll want to go find out. My answer: go . The desert is an amazing place--all our different deserts.
FTC Disclosure: I checked Connect the Stars out of my library, and received nothing from the writer or publisher for my honest review. The opinions expressed are my own and those of no one else. I am disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials in Advertising."
This does sound good. Heck, I never got over the feeling that it's hard to make friends.
LOL! True enough. (In a funny way, the internet has made that easier. Or maybe it just allows us to take our time without it being so obvious? I only know that I have made a number of real friends, some I've actually met in person and even backpacked with, through the internet).
I loved the cover too, but I think I'll pass on the book.
Probably a good call. This one I think will appeal more to the kids than to us grownups.


text:
Mythology Monday: Pygmalion and Galatea
July 6, 2015 June 6, 2015 / kaitlinbevis
Once upon a time, there was a woman made of stone. She was beautiful and perfect and strong. Until one day, she was found by a lonely man who could not find a woman to love him.
Blind to her beauty, Pygmalion took a chisel to her and reshaped her to better fit his desires. Though her flesh softened and her shape changed, she remained strong and unchanged within.
Frustrated, the man appealed to the gods. "The women of Cyprus are all poor and whores and unsuited to a man of my station. Breathe life into this stone, and I shall build a great temple in your honor."
"The city of Cyprus is filled with women made of flesh and bone," The goddess of wisdom reasoned. "Perhaps the problem does not lie with them."
"Do not blame the prey when you are not worthy of the hunt," said Artemis.
"Never." Ares's eyes glittered with disdain.
"Build me a temple that touches the sky and the woman is yours," decreed the God-King.
Pygmalion agreed and when the last stone of the temple was set into place, Zeus breathed life into the statue, hollowing out her insides, removing every trace of who she once was and replacing her very essence with what Pygmalion wished her to be.
According to the myth, she was beautiful, dedicated, and obedient to her husband's every whim. The perfect wife.
But I know better than anyone that perfection has a price.
~@~
I'm going to be honest, I *hate* this myth. I hate the message it sends. I hate that it's so popular. Everything about this myth makes me feel kind of sick. So be warned, my distaste WILL be reflected in my tone. But it's important in my next book. So…mine it for spoilers.
Pygmalion was a skilled sculptor who grew tired of he local prostitutes (technically these women pissed off Aphrodite, so she cursed them into prostitution). Apparently every woman he met, ever, was unworthy of his love, so he made one of his own. He carved a beautiful, pure, clean woman, and fell in love with it.
Like, really in love with it.
At Venus' next festival, Pygmalion made a sacrifice on the alter and prayed for a girl who was like his statue. He later returned home, began to make out with his statue, and noticed its lips were warm.
Let's pause there for a minute. Pygmalion did not go home assuming his statue would be alive. He didn't check it for a pulse or anything. He didn't even ask Aphrodite to bring his statue to life. He asked for a girl *like* his statue to appear on his doorstep (where he likely would declare she was unworthy, slam the door, and start a war of epic proportions). The idea that his statue could come to life had not actually occurred to him before he started making out with it.
Take from that what you will.
Anyhow, the statue comes to life and Pygmlion names it Galatea, or Galathea, or Elise. That last name you may want to remember when you read Venus and Adonis. Just sayin.
They get married and have a daughter named Paphos, who had the Island of Paphos named for her, near the rock of Aphrodite (where Aphrodite was born). They also had another daughter named Metharme who married King Cinryas, who had a daughter named Myrrah, who slept with her father and had a child named Adonis. More on him next week.
As much as I hate this myth, it's become a major part of Aphrodite's trilogy. My favorite part of studying mythology is seeing where the myths intersect. They're all connected, which makes my job of rewriting them a lot more fun.
← Happy Fourth of July!
Way Back Wednesday: Pygmalion →


text:
HomeLatest sports
Terry McLaurin says ref told him he was lined up legally before penalty that cost Commanders a TD
The Washington Commanders have a bone or two to pick with the officials after their 20-12 loss to the New York Giants on Sunday Night Football.
Needing a touchdown and two-point conversion to send the game to overtime with a minute left, the Commanders found themselves on the Giants' doorstep when a scramble from quarterback Taylor Heinicke gave them 3rd-and-goal at the 1-yard line.
Commanders running back Brian Robinson seemingly scored that necessary touchdown on the next play, until it was called back due to an illegal formation penalty on wide receiver Terry McLaurin. The Pro Bowl pass-catcher was not lined up close enough to the line of scrimmage, wiping the score off the books.
However, a subsequent replay appeared to show McLaurin asking the line judge if he was lined up correctly and twice adjusting his position. The player confirmed that to be the case after the game.
Heinicke was incensed after the game, reportedly saying "He gives the thumbs-up to Terry, what the f*** is that?" Referee John Hussey told a pool reporter that McLaurin had to be lined up in front of the belt line of the center, which he was not, and said an official typically doesn't have to tell a player whether or not they're positioned legally.
Somehow, that might not have been the worst of it.
One incomplete pass later, the Commanders had 4th-and-goal from the 6-yard line. Heinicke danced in the pocket for a few seconds, then targeted wide receiver Curtis Samuel in the end zone for a potential game-tying touchdown.
The pass fell incomplete after some, well, let's just call it aggressive defense by Giants cornerback Darnay Holmes for now. Upon further review, though, it became clear that Holmes was much more than just aggressive while covering Samuel. He was basically pretending to be his opponent's backpack.
Many on social media were quick to call the play a missed pass interference penalty by the referees. Unfortunately for the Commanders, there wasn't much they could do from there beyond watch the Giants kneel out the clock and move into a commanding position in a close playoff race.
Commanders head coach Ron Rivera wasn't too happy about the situation after the game. Perhaps wisely, he declined to provide reporters his in-depth thoughts on the game's officiating:
"Don't ask me about the refereeing because I can't answer the question."
Of course, the Commanders lost for more reasons than just the officials, something Heinicke noted. The team struggled to protect him for most of the game, most notably on a Kayvon Thibodeaux fumble return touchdown. But it's hard not to think the team should have had two different chances at a game-tying two-point conversion, and that's never a fun way to lose.
Terry McLaurin thought he had his best foot forward. It ended up costing the Commanders a massive touchdown against the Giants. (AP Photo/Susan Walsh)
Previous articleCDC investigating multistate outbreak of norovirus stemming from raw Texas oysters
Next articleBitcoin Price and Ethereum Prediction; Breakout Patterns Will Drive Price Action


For nearly 30 years, the name Dex Romweber has been the password to a cool club. It lets the doorman size you up through the slit in the green door that leads to a world where rock and roll is still real… and real, real gone. Dex's progeny, impacted by his wild and wildly influential work in Flat Duo Jets, his Duo and solo, includes the White Stripes, the Black Keys, the Kills, Man or Astroman? and dozens of other bands that have stripped down, turned up, and cut loose.
Carrboro, with its cover shot of the railroad tracks that run through his hometown, where on a grey day or a dark night you'd find a young Dex immersing himself in the music of his idols, is his fourth record for Bloodshot (and his first for us a solo artist). Through 13 originals and far-ranging covers, Dex reaches into his steamer trunk of influences and inspirations, and fabricates an enthralling sonic quilt. As Dex describes his approach, "It doesn't matter to me what genre—if I like a song I might record it." It's all different, but all of one piece.
On Carrboro, Dex assumes several musical mantles (and uncharacteristically plays all or many of the instruments). There's the sparse and jumpy hillbilly liveliness of "Knock Knock (Who's That Knockin' On My Coffin Lid Door?)" with help from Rick Miller of Southern Culture On The Skids; "Lonesome Train," originally recorded by Cecilia Batten in nearby Chapel Hill in '57; and a take on the T. Bone Burnett-penned "I Don't Know," sung by The Dude and Ryan Bingham for the film Crazy Heart (says Dex: "the lyrics seem to be so much about my own life… damn I just had to record it"). With the fuller sound of the New Romans, a 10-piece Chapel Hill collective, "Nightide" is a Tarantino grind on the surf-deck of the USS Enterprise, while Mahalia Jackson's "Trouble of the World" throbs with a thrilling apocalyptic gloom.
Dex's last-call crooner persona kicks off the album with a surprising contemporary cover, that of English singer-songwriter Findlay Brown's "I Had A Dream" ("It affected me deeply personally when I first heard it," Dex explains).  He embraces "Smile," a Charlie Chaplin tune (yeah, you read that right) and the Jerry Lee Lewis obscurity "Tomorrow's Taking Baby Away" with Waits-ian levels of resignation and weariness. And no Dex Romweber record is complete without some instrumental wizardry. There's the tiki surf of "Midnight at Vic's" and the sunset dreamscape of "Out of the Way." He even turns "My Funny Valentine," the Rodgers and Hart Broadway chestnut from the 1930s into the soundtrack to a ghostly roller rink murder caper.
In the end, the album plays like the jukebox at the full service honky-tonk saloon, jazz club, Tin Pan Alley pitch house, and blues joint along the tracks. Get off at the Carrboro station.


Well, now you can! You can from that page download html, txt or PDF versions, or just read it here on CnV. It's published under a Creative Commons licence, so feel free to share!
And remember, if you enjoy it, please do consider signing up to my writing and bookbinding newsletter (or sign up in the sidebar there to your right).
Hi Suw, just to say that I've just finished reading Argleton on my phone's Kindle app, thanks to a link on boingboing, and I loved it. As someone who is very fond of the writings of William Gibson and Charles Stross, particularly William G's, for the way he blends the tech into great storytelling your story really struck a chord with me. And it described an England that was very familiar to me, some parts very well indeed. Thank you for sharing it and making it available as a free download. I've got your blog bookmarked on my homepage now, so I can keep up to date with future writings.
What a great story! I also loved the way the geek was a woman & that it was the man who couldn't drive. A very pleasant departure from the usual cliche.


text:
Where is Stuart Broad, the tall, experienced bowler who should, on paper, be getting a wicket or two Down Under?
Stuart Broad (via Channel 5)
The pitch is flat, say tetchy England fans. This is the short version of the recurring Test match question: the pitch is flat, so what are you going to do about it?
England went with a bit of fast-medium. After that, they tried a bit more fast-medium, then a bit more, then a quick burst of Moeen Ali, then back to fast-medium. Maybe once the ball was old and the bowlers fatigued, the God of Pity might bring them some lateral movement.
The God of Pity was unmoved.
As we observed on the first day, wickets are hard to come by on this Waca pitch. England's attack, which is spectacularly ill-suited to these conditions, was always going to struggle more than Australia's did. An even bigger crime was arguably that their batsmen could only muster one proper partnership in the whole first innings. The lower order collapse has been given a lot of attention, but the top order nothingness was worse.
But on today's performance, it's hard to see what difference it makes anyway. James Anderson has made the most of favourable conditions and Craig Overton has been game, but none of the other bowlers have had any real impact on this series.
If we had to pinpoint the biggest hole in the England team on this tour, it's been Stuart Broad. England's tallest bowler and capable of bowling at a fair lick from time to time, he also has experience of bowling well in Australia in the past – 21 wickets at 27.52 in the 2013/14 series when England got hammered.
Broad really should have presented the greatest threat, yet at the time of writing he has five wickets at 50-odd with every sign that the ratio between those two numbers will further deteriorate.
He hasn't even looked that pissed off. To see Broad accepting his cap at the end of another fruitless over with an utterly blank face is to be momentarily transported to a parallel dimension.
Broad is a man who smiles when he's winning and grouches about the place like a sleep-deprived man who's just trodden on an upturned plug when things aren't going his way. Bad days have historically led to a snowballing fury that has resulted in either a wicket or some kind of warning from the match referee.
Now there is only a kind of medicated mellowness. It's a mood that's shaping the series, but not in the way that England would like.
What to expect from Stuart Broad
Like Stuart Broad… but different
Stuart Broad fails to trouble the speed gun
December 16, 2017 / King Cricket / 17 appeals
Australia cricket news, England cricket news
Stuart Broad
England end up looking a bit fast-medium
The day James Vince didn't edge one
Bail-out
Overton's been very game, all things considered. I hope he isn't going to do himself any damage in a vain cause.
Stokes aside, this team was about as good as England could have sent.
There aren't any great fast bowlers who were left behind, Toblerone and Wood wouldn't have been any more effectual if they had been fit, and there wasn't a magic batsman who would have improved things noticeably.
English cricket doesn't often produce players who can win in Australian conditions, and that's fine. Occasionally the stars align and you get 2010-11, or both teams are pretty rubbish and you get 1986-87.
Some time around 2040 England might win over there again.
But I'd probably back what's left of this team to win in England in 2019. If Stokes isn't in prison and they can find another batsman or three.
Mercifully I have been kinda-busy these past few days, not least singing an early Tudor-period song in a Tudor Hall in medieval German, like you do:
http://ianlouisharris.com/2017/12/14/gresham-society-soiree-barnards-inn-hall-14-december-2017/
It's extraordinary how much such a challenge can take one's mind off England's pitiful Ashes campaign. Yet still I have been "grouching about the place like a sleep-deprived man who's just trodden on an upturned plug…"
…how do you know this stuff, KC? Have you infected our PCs with worms that switch on the webcams and let you watch us stumbling around in the early hours in the vain hope of some good news in the cricket score? That would be well-clever if you have.
One of the worst days I can remember for England cricketings.
But Farbrace thinks they bowled pretty well and he was happy with their body language, so that's ok.
Hoopy
I was at my work's do last night and we ended up doing the old top five films, top five albums(no compilations) just to avoid talking shop. All of which got me thinking today about my favourite eleven cricketers. To make it clear; this is based on Test cricketers that I'd like to have a pint with and not based on career stats. With a tequila fuelled hangover, I jotted down a list of names, then rearranged it into batting order:
Mike Atherton
Stephen Flemming
Adam Gilchrist(wk)
Wasim Akram
Brett Lee
Ian Bishop
Shane Bond
With that done, I made a list of Test cricketers that I respect as players, but wouldn't want a pint with:
Mathew Hayden
Geoff Boycott
Viv Richards
Brian Lara (no idea why you're in this list…soz…I'll buy the first round)
Kevin Pietersen
Ian Botham
Alec Stewart(wk)
Dennis Lillee
Richard Hadlee
Waqar Younis
Just for fun, which would win?
Los bastardos have it for me.
Yup – it would be a more uneven series than these Ashes in my view…
…the "No Thanks, I'm Washing My Hair This Evening XI" winning by a country mile over the "I'll Have A Pint Of Mild, Please XI".
I'd differ on some of your choices, though. But I think my criteria are based more on "who would make for an interesting one-off evening's company?" than "who might I want as my friend?" On my criteria, several of the choices would be the other way around.
Viv, Both, Lillee, Hadlee and Warne should all make for a fun and interesting evening – albeit not one I'd want to repeat too often.
Not too many of your "fancy a pint" team strike me as fun, Hoopy.
I'm not sure Bishop, Bond and Lee will stand up to bowling through a whole match.
curious about why you have waqar in that list, he isn't really reputed to be a world class asshole like most of the other guys
Probably unlikely to go for a pint, though.
ah, but then you have akram in list 1
Justification:
Ath: Played for Lancs and, when carrying out an interview, slouches better than anyone else I've ever seen.
Mark Taylor: Perhaps the only Aussie I'd really value an opinion from.
Stephen Flemming: The best captain I've ever seen (I never saw Brearley)
Sachin Tendulkar: Really?
Kumar Sangakkara: The best person to have ever lived on the face of the planet.
Adam Gilchrist: Massive ears and massive bat and, I think, nice bloke.
Wasim Akram: Played for Lancs. Bowled a fucking ace yorker. Spoke to me at OT once.
Brett Lee: A proper fast bowler who never really got a bit fast medium. I think he was/is probably quite a decent fellow.
Ian Bishop: This https://www.youtube.com/watch?v=0TW5fKgLMHk
Shane Bond: Dunno, just always thought he was ace.
Muttiah Muralitharan: well, he could always give you an over before lunch.
142/0. Ouch. Serves him right for leaving Leics.
I'm sure England will do just great batting today, though.
Yep, batting great. Cook's longest run without a 50 ever, I believe. So at least he's overdue.
If you're going to lose, lose embarrassingly badly, that's what I always say.
Hope fading. Soon we will experience the sweet release of defeat.
Royal Highlights
Andrew Strauss repairs his stats
England's reactive batting
Mitchell Johnson, all-rounder?
Is it okay to drop Jos Buttler?


text:
stuart school of business, illinois institute of technology
A capstone project with Associate Professor Sang Baum Kang gave Trevor Wheeler the chance to build on his classroom learning and to show his understanding of investments and trading. Illinois Tech's Stuart School of Business was founded by a gift from Lewis Institute alumnus Harold Leonard Stuart in 1969, and joined Chicago-Kent at Illinois Tech's Downtown Campus in 1992; it phased out its undergraduate program (becoming graduate-only) after spring 1995. The Stuart School of Business (often just Stuart or Stuart School) is an academic unit of the Illinois Institute of Technology, a private Ph.D.-granting technological university. A minimum score of 85 on the internet-based TOEFL, 600 on the paper-based TOEFL, or 7.0 on the IELTS exam is required for admission consideration, A one-page professional statement of goals and objectives, At least one letter of recommendation from an academic or professional reference. Official TOEFL or IELTS score, if required. Domestic candidates for the Master of Science in Finance program may apply for the scholarship, which awards students up to $20,000 toward this degree program. Chicago Innovation Scholarships of up to $14,000 are available for students in the Accelerated M.B.A. program who demonstrate a continuing commitment to innovation in the Chicago region. In the highly ranked Master of Science in Finance program, students learn the latest industry-relevant ideas and technologies from faculty who bring their career knowledge of the marketplace to the classroom. Companies that have hired Stuart M.B.A. graduates include: Accelerated but not abridged, the Accelerated M.B.A. program provides the solid background to thrive in an innovative business environment, including marketing, finance, business analytics, economic principles as applied to business, operations and organizational design, ethics, and leadership. As an intern at CME Group, he saw the value of his business studies in his on-the-job experience. Business at Illinois Institute of Technology Stuart School of Business provides intellectually rigorous business and management education at all levels, from baccalaureate to doctoral. With her Illinois Tech M.B.A., Leslie Voegtlin has the background for career advancement that she wanted. Apply for a waiver with résumé and transcripts. Accelerated to meet the pace of working professionals, the program features a two-year, part-time schedule with Saturday classes at Illinois Tech's convenient Conviser Law Center in downtown Chicago. The program offers convenient Saturday classes in downtown Chicago. College of Computing Stuart School of Business Request Info Visit Apply Illinois Tech's Master of Mathematical Finance program provides a superior quantitative education to prepare students to pursue careers in quantitative analysis and financial engineering. Through rigorous, innovation-focused academics and hands-on learning, Stuart School of Business's unique accelerated M.B.A. program prepares busy mid-career professionals to advance their careers, especially in organizations where technology is a key source of competitiveness. I hope to leverage the connections I make through Chicago Innovation as I advance further into my career.", —Christopher Hoffmann (M.B.A. '19), Lead Rotating Equipment Engineer, Honeywell, —Association to Advance Collegiate Schools of Business International, Director, Master of Business Administration, Associate Professor of Operations Management, Assistant Director, M.S. "Picking a graduate program is all about fit. You'll find challenging business and management programs taught from an applied perspective and attuned to leading-edge industry practices. The program offers convenient Saturday classes in downtown Chicago. Stuart School of Business. Illinois Tech welcomes you to join our community of people who discover, create, and solve. To report a incident, problem or suggestion, please e mail us at supportdesk@iit.edu or call 312.567.3375 (7DESK).. IIT's academic computer labs, classrooms and kiosk PCs have a … in Marketing Analytics, Director, Center for Advancing Corporate Performance, Professor of Operations and Technology Management, Coleman Foundation Clinical Associate Professor of Entrepreneurship, Director, Master of Technological Entrepreneurship. A capstone project with Associate Professor Sang Baum Kang gave Trevor Wheeler the chance to build on his classroom learning and to show his understanding of investments and trading. GMAT or GRE score within five years of testing date. Partnerships with alumni and other leaders in the finance industry provide opportunities for students to gain valuable experience as they work on real-world projects, engage in internships at top companies, and network with finance professionals. They learn the latest industry-relevant ideas and technologies from faculty who are both practitioners and scholars, bringing their career knowledge and understanding of the marketplace directly to the classroom. Students take classes alongside a group of peer professionals who bring diverse perspectives and career experiences to class discussions and group projects. At Stuart School of Business, students can study in one of the nation's premier Master of Science in Finance programs in … Students are also eligible for Chicago Innovation Scholarships of up to $14,000. Networking events and activities hosted by Stuart School of Business's partner, Chicago Innovation, give students opportunities to engage with entrepreneurs and professionals from industries across the city's innovation-focused business community. As a leading financial center, Chicago offers many opportunities for internships and networking.
Sine Mora 360, Modal Verbs Worksheets With Answers Pdf, Barn Swallow Babies Died, Market Pantry Chocolate Ice Cream, Morgan County, Wv Population, A First Course In Linear Algebra Kuttler, Aia Owner Architect Short Form Agreement, Date Energy Balls, Walmart 25 Lb Flour, Houses For Sale In Meadow Vista, Ca, What Is A Funeral Visitation, How Many Calories In Pico De Gallo With Avocado,


For your next special event! Our facility can accommodate guest counts from 30-275 so there is no event too large or too small. We have state of the art audio systems as well as a lounge area, indoor and outdoor bar, prep kitchen, fully paved parking area with lighting and many other amenities that you and your guests can enjoy.
Use of venue, ceremony site and 4 outdoor entertaining areas, up-lighting, tables, cross-back wooden chairs, hand-carved cedar ceremony benches, cocktail table and stools, wooded display tables, yard games, cleanup and taxes.
No cleanup or service Fees!
Includes fire attendant Fire maintained and managed. Includes tiki torches and firewood. No penalty for inclement weather if canceled by 2pm day of. The fire typically start after ceremony pictures are taken so smoke isn't in view.
3 for $75/each for patio heaters Heaters come with propane and comfort levels are monitored and adjusted by our staff as required. Typically started after ceremony during cocktail hour till send off.


The benefit for endoscopic therapeutic procedures includes an amount for diagnostic endoscopy. This should therefore not be charged for separately.
The benefit for gastroscopy and sigmoidoscopy includes an amount for sedation.


text:
REDC adds three to board of directors
RUTLAND—Continuing the reorganization and refocusing of the Rutland Economic Development Corporation (REDC), the REDC Board of Directors has elected new members from three of the region's leading companies.
John Casella II, 31, of Casella Construction; Shana Louiselle, 30, of Vermont Electric Power Company (VELCO); and Mark Werle, 52, of Ryan, Smith & Carbine, Ltd., will join the board immediately.
"All three are accomplished professionals who bring expertise in their fields as well as fresh perspectives to economic development in the region," Executive Director Lyle Jepson said. "They also bring new vitality and a demonstrated commitment to the region, which will be invaluable as we expand REDC's focus on business and professional recruitment."
Casella, who lives in Castleton, is operations group manager for Casella Construction and serves on an industry-related committee advising the Vermont Agency of Natural Resources on matters pertaining to construction and demolition.
Louiselle of Pittsford manages corporate communications and governmental affairs at VELCO, where she has assisted the facilitation of the Vermont System Planning Committee, a statewide collaborative stakeholder process for addressing electric grid reliability planning in Vermont.
Werle, a Killington resident, practices insurance law in Vermont and New York and leads Ryan, Smith & Carbine's New York practice group. He is also active in environmental, commercial and real estate litigation. Werleis a past member of the Town of Killington Planning Commission.
Board Chairman Mark Foley, Jr. said the election of the new board members followed several months of discussion by members of REDC's Executive Committee and would provide invaluable insights. "Their background is varied, but the common denominator is a love for Rutland and Rutland County, and a commitment to helping make this an even better place in the years ahead," Foley said.
The REDC Board recently approved a new mission statement, "to use collaboration, creativity and ingenuity to recruit talent and businesses of all kinds, grow and retain employers, and promote a healthy and vibrant commercial and residential real estate market. We believe economic development is a team sport, capitalizing on fun, fresh ideas, passionate people, and open, inventive partnerships."
REDC's new offices are co-located with Castleton University at Castleton Downtown, 67 Merchants Row, Rutland, Vt.
John Casella IIKillingtonLyle JepsonMark WerleREDC adds three to board of directorsREDC BoardRutlandRutland Economic Development CorporationShana LouiselleTown of Killington Planning CommisionVelcoVermont Electric Company
Compass Music and Arts Foundation seeks matching funds for the performance hall
ANR announces approved tactical basin plan for the Battenkill, Walloomsac, and Hoosic river basins


JJ Hickson receives a nice bounce-pass from Nicolas Batum for a strong one-handed throw down against the Sacramento Kings. Hickson has 17 points and 14 rebounds in the Blazers' victory over the Kings.
This video was posted in JJ Hickson and tagged JJ Hickson, JJ Hickson Dunks, JJ Hickson Highlights. Bookmark the permalink.


text:
Early Morning Shooting Leaves 2 Dead In St. PaulTwo people are dead following an early Thursday morning shooting in St. Paul.
How Does Soap Work?
By Heather Brown October 24, 2018 at 10:10 pm
Filed Under:Centers For Disease Control And Prevention, Good Question, Hennepin Healthcare, Local TV
MINNEAPOLIS (WCCO) — There's a constant reminder as we approach the height of flu and cold season — wash your hands with soap.
That has Dan from Blaine wanting to know: how does soap work? Good Question.
"Soap is important," says Dr. Caitlin Eccles-Radtke, an infectious diseases specialist at Hennepin Healthcare.
In one study conducted in rural Bangladesh, researchers found a baseline of 12.5-percent of kids having diarrhea. That was cut to 6.9-percent when they washed their hands with just water. It went down to 3.7-percent when they also used soap.
Most people know that oil and water don't mix, which is why only using water doesn't do the proper job. According to W. Stephen McNeil, an Associate Professor in the Department of Chemistry at UBC Okanagan in British Columbia, soap essentially creates little balls that trap the dirt and oil, while still allowing them to move through the water. That way, when someone rinses off the soap, all of the junk that soap collected goes with it.
McNeil also points out soap kills germs, whether or not it says antibacterial. It does so by breaking the cell wall of the bacteria.
The general recommendation from the Centers for Disease Control and Prevention for handwashing with soap is 20 seconds.
"We always tell people– especially kids, but adults could do it too– to sing the alphabet slowly," says Dr. Eccles-Radkte.
She says people don't have to wash their hands every time they touch something, but should do it after using the restroom, before eating or preparing food, after changing diapers or touching the trash and after sneezing or rubbing your nose.
"If you look at all the literature and medicine, handwashing is the most important thing," says Dr. Eccles-Radkte.
Heather Brown loves to put her curiosity to work to answer your Good Questions on WCCO 4 News at 10, and helps you kick your weekdays off on WCCO This...More from Heather Brown