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November 9, 2021 samversionone
Kathy Rain: Director's Cut | Nintendo Switch Review
Clifftop Games and Raw Fury's Kath Rain originally saw release back in 2016 on PC and later for Android and iOS. It was received quite favorable amongst critics, which is probably why five years later, we're seeing a Kathy Rain: Director's Cut. Kathy Rain: Director's Cut expands upon the original in almost every way. There's an extended storyline with a new ending, new areas to explore, new dialog, improved art, controller support, and more. Basically, if you are a fan of Kathy Rain or have always wanted to play it, this is the version you need to check out.
Kathy Rain: Director's Cut is a point-and-click adventure-mystery game set in the '90s. You play as the titular character, Kathy Rain, a college student who has returned back to her hometown of Conwell Springs due to the death of her grandfather. While her visit there was just to attend a funeral, she soon discovers that there are plenty of questions surrounding his death and embarks on a journey to discover the truth of the secrets the town and its residents are hiding.
Originally conceived as a game using a mouse pointer and later touch Kathy Rain: Director's Cut now has full controller support thanks in part to now being on the Nintendo Switch. It can be played via the Joy-cons or with a regular controller. The controls are pretty self-explanatory and aren't too difficult to learn. It is interesting how they dealt with the "pointing-and-click" aspect of the game using the joysticks. If you click the left joystick and hold it down, you can see all the areas you can interact with. The right joystick lets you select specific points of interest and if you press the right trigger, you'll interact with those. It's a pretty good solution instead of just having some sort of floating pointer. Of course, if you wanted to, you can just go full touch as the Nintendo Switch version also supports touch controls.
Moving on, the graphics in this game are quite good. They are very retro and remind me of point-and-click games from the past, such as King's Quest. Character designs are very detailed as are all the environments. What I'm also really liking is the full voiceovers here for the dialog. While most of these games in the past were mainly all text-based, having full voices makes the experience so much more immersive and interesting.
Now in terms of the storyline and gameplay, Kathy Rain: Director's Cut is pretty much everything you'd expect from a point-and-click adventure. There's a really deep story here and a mystery that needs solving. The character herself also seems fairly likable so it just makes playing the game more inviting. Playing the game is also a pretty nice experience. Think of it as an interactive book. You just follow along with the story and when it needs your interactions, you give it. Tap on anything that can be tapped and look at all the clues and items you gather. I do also like the puzzle elements in the game which is also classic point-and-click. Some puzzles require items you find and some items can be combined with each other.
Overall, despite the original Kathy RAin being an older game, Kathy RAin: Director's Cut is still a fantastic experience for those who want to experience it again or for those who haven't. I'm of the latter group and found the story and overall game quite good. The exploration elements and puzzle elements are neat and I just couldn't wait to continue on with the story whenever I had to stop. That's a good sign for a game that is so stories dependant.
Kath Rain: Director's Cut is available now on the Nintendo eShop.
Received game from developer and/or publisher for coverage purposes.
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College affordability looks for a passing grade from House members
By Jason SchottFox Business
College affordability: Will taxing the wealthy help or hurt?
Third Way Director of Education Tamara Hiler discusses 2020 Democratic candidates' plans for college students and the impact on free tuition.
The House of Representatives' Committee on Education and Labor introduced a comprehensive overhaul of the higher education system - the College Affordability Act – that will lower the cost of college for students and families, improve the quality of higher education through stronger accountability, and expands opportunity for students by giving them the support and flexibility needed to succeed.
"With this Act, the House Democrats are delivering on the top priority for the American people," said Speaker Nancy Pelosi, who was on hand for the press conference introducing the landmark bill. "Every time we meet with students and families, we hear the same thing: college affordability in America is just inaccessible to them. We must put an end to years of Republican inaction because we can no longer afford to do nothing when 44 million Americans are saddled with $1.5 trillion in debt."
This groundbreaking legislation comes more than a decade after the last reauthorization of the Higher Education Act (HEA) and at a time when the combination of rising tuition and inconsistent quality is undermining students' access to the benefits of a college degree.
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BIDEN'S $750B 'BEYOND HIGH SCHOOL' EDUCATION PLAN WOULD BE BANKROLLED BY 'SUPER-WEALTHY'
"The College Affordability Act is a responsible, comprehensive overhaul of our higher education system that would mean students can spend less and earn more," said Committee on Education and Labor Committee Chairman Bobby Scott (D-VA). "This proposal immediately cuts the cost of college for students and families and provides relief for existing borrowers. At the same time, it improves the quality of education by holding schools accountable for their students' success, and it meets students' individual needs by expanding access to more flexible college options and stronger support – helping students graduate on time and move into the workforce."
A major focus of the College Affordability Act is the rising cost of tuition, which the legislation will take on by restoring state and federal investments in public colleges and universities. This should reduce the burden that has been shifted to students and their families.
"It's a little bit surprising that the bill has been introduced; there's been speculation about it for quite some time," said Jim Boyle, a Washington D.C. based consultant who is the former president of the College Parents of America. "Reauthorization of the Higher Education Act, over the years, has been delayed and punted by various Congresses and, so, this introduction of it is just a step in the process. There's still curiosity about what will happen in the Senate, and of course, there will not be a reauthorization of the Higher Education Act unless, somehow, the House and Senate can come to an agreement on the various elements that will be a part of it."
The College Affordability Act also promises to make college affordable for low- and middle-income students by increasing the value of Pell Grants, ease the burden of student loans by making existing them cheaper and easier to pay off, and crackdown on predatory for-profit colleges that defraud students, veterans, and taxpayers.
"Every time we meet with students and families, we hear the same thing: college affordability in America is just inaccessible to them."
- House Speaker Nancy Pelosi
"The issue of affordability is a complicated one to address," said Boyle. "Part of the reason is because it's attempting to put a government solution to what really is a market problem. There are certain degrees that are viewed as extremely valuable in the marketplace, and institutions that have a strong brand and reputation can charge whatever they want, and they would have people that are willing to pay."
Boyle believes that most institutions now "are going out of their way to make their pricing more attractive to students, and they can and will take advantage of government programs that can make the cost less onerous, but someone ends up paying for it in the end, and that's the taxpayer."
The new plan will also hold all schools accountable for providing students a quality education that leads to a rewarding career, and helps improve graduation rates by providing stronger wraparound services to keep students in school and on track.
While there is disagreement between the parties when it comes to the issue of for-profit colleges or how necessary it is that people attend college at all, the College Affordability Act aims to satisfy both parties.
"The whole area of vocational education, as some would call it, or workforce training, as others might call it, that's an area where, I think, there is some bipartisan agreement," said Boyle. "When you hear, and Chairman Scott, for instance, talked about the money that might be used for short-term Pell Grants programs. Those are for programs often offered by community colleges that provide a chance to get a credential that can very quickly lead to a job or promotion within a company because that is required to reach the next step. There's bipartisan agreement that an investment like that makes sense."
The Act also promises investment in the critical institutions that enroll underserved students by increasing and permanently reauthorizing mandatory funding for Historically Black Colleges and Universities, Tribal Colleges and Universities (TCUs), and other Minority Serving Institutions.
CLICK HERE FOR THE ALL-NEW FOXBUSINESS.COM

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Current Topic: On Sunday, January 6, we began a new Sunday Morning Bible Class called: The WORD at Work in a Little-Bitty Church with Big-City Problems. The city is Corinth. The small group of believers there had some real big challenges to their faith in Jesus. Their challenges are no different than ours. Our Lord inspires Paul to tackle each problem head-first. As we unfold this letter we will be amazed at Paul's clarity, patience and grace as Jesus uses Paul to share God's amazing grace in the solutions to the problems. Come see that grace in action.
Current Topic: We are currently studying the Old Testament book of Isaiah. We are working through this study at our own slow pace, mining the treasures of God's Word as we go.
Current Topic: Contentment. Are you content? In our society full of "stuff", it still can be elusive. Grow in contentment in Ecclesiastes beginning on Wednesday, Jan. 9 at 1pm. Join us!
Description: Assist members and friends with chores around the house.


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Steven Spielberg's company pulls out of CBS hit 'Bull,' reports say
Home / Entertainment / Steven Spielberg's company pulls out of CBS hit 'Bull,' reports say May 10, 2019 Entertainment 4 Views Michael Weatherly stars in "Bull" (Photo: CBS) Steven Spielberg and his production company Amblin Television have pulled out of the CBS hit show "Bull" [See More] Michael Weatherly "We can confirm that we are no longer associated with the show," a spokeswoman for Spielberg's company, Amblin Television, told The New York Times. Spielberg and Amblin Television co-heads Darryl Frank and Justin Falvey served as executive producers on "Bull" for the first three seasons of the procedural drama. The show was renewed May 9 for a fourth season. In December, The Times reported that CBS paid actress Eliza Dushku $ 9.5 million to settle her claim that she was sexually harassed by Weatherly. Weatherly told The Times he made jokes to Dushku "mocking some lines in the script" and he was "mortified to have offended here." In a lengthy Boston Globe essay, Dushku wrote that the harassment was caught on camera and lasted "weeks" while she worked on the series. Industry website Deadline.com referred to the move by Spielberg as "bold" since a long-running CBS procedure is considered one of the most lucrative propositions in TV. Spielberg and his wife, Kate Capshaw, have been major Supporters of the Time's Up movement Dushku, 38, said in a March deadline interview that she met with Spielberg "and brainstormed and discussed possible solutions for this systemic imbalance of power, the abuse and harassment…
Home / Entertainment / Steven Spielberg's company pulls out of CBS hit 'Bull,' reports say
May 10, 2019 Entertainment 4 Views
Michael Weatherly stars in "Bull" (Photo: CBS)
Steven Spielberg and his production company Amblin Television have pulled out of the CBS hit show "Bull" [See More] Michael Weatherly
"We can confirm that we are no longer associated with the show," a spokeswoman for Spielberg's company, Amblin Television, told The New York Times.
Spielberg and Amblin Television co-heads Darryl Frank and Justin Falvey served as executive producers on "Bull" for the first three seasons of the procedural drama. The show was renewed May 9 for a fourth season.
In December, The Times reported that CBS paid actress Eliza Dushku $ 9.5 million to settle her claim that she was sexually harassed by Weatherly.
Weatherly told The Times he made jokes to Dushku "mocking some lines in the script" and he was "mortified to have offended here."
In a lengthy Boston Globe essay, Dushku wrote that the harassment was caught on camera and lasted "weeks" while she worked on the series.
Industry website Deadline.com referred to the move by Spielberg as "bold" since a long-running CBS procedure is considered one of the most lucrative propositions in TV.
Spielberg and his wife, Kate Capshaw, have been major Supporters of the Time's Up movement
Dushku, 38, said in a March deadline interview that she met with Spielberg "and brainstormed and discussed possible solutions for this systemic imbalance of power, the abuse and harassment that we've been seeing and hearing and experiencing and both in our industry and beyond. "
Read or Share this story: https://www.usatoday.com/story/life/people/2019/05/09/steven-spielberg-amblin-cbs -show-bull / 1159535001 /


Aquarius Vintage SF is a 70s inspired vintage shop born from Mara's love for anything antique and avant-garde. Being a San Francisco native raised around the Sunset District and Golden Gate Park, Mara is influenced by the bohemian and laid back culture these neighborhoods express. She travels far and wide to find unique pieces of clothing and jewelry that fit her free-spirited style. Mara is passionate about music and social good. Being an Aquarius woman, she is a creator with eccentric ideas. A dreamer, sun child, humanitarian, old soul always looking for the next adventure.
Dubbed by many as a fashion icon, his gifted eye for design and talent were instrumental to the ascent of Fred Segal as one of the most influential specialty boutiques in Los Angeles.
John and his line have been featured in Vogue, Italian Vogue, BAZAAR, Time, and C Magazine. Flaunt Magazine stated, Like a fashion clairvoyant, he seems to have a knack for knowing what everyone will be wearing before knowing themselves.
A collection of closet staples built on a foundation of neutral basics and graphic tees.
We design for sun-kissed, free spirits with a penchant for travel and an eye for clean lives.
Stillwater employs mindful business practices.
We source recycled materials and encourage sustainable practices and fair-wage domestic production.
Leaving the world a better place than we found it.
Blending west coast ease and east coast edge, the brand is synonymous for pairing feminine styling with masculine elements to create styles that are made to mix and match. Pieces are wearable, versatile, and perfectly undone, making them ideal to dress up or down.
Since the creation of the brand in 2012, Knot Sisters has grown to represent the friendship and bonds that are built between women, whether it is swapping outfits, sharing secrets, or having a shoulder to lean on. It's the connection anyone has ever felt for a sister, even if you are...Knot Sisters.
Pour l'air is about finding moments to love in the everyday. We use scent and stories that ignite inspiration and ideas. Room fragrances that enhance the everyday.
The stories and look of the candles are inspired by writers sitting in a corner of a café or a cozy home writing out thoughts of living light. The handwriting, the typewriter font, the letterpress labels are designed to create the feeling of someone telling you a story, and you get to put yourself in it. Each story has a purpose. The box is inspired by a young Paul Newman in a white cotton tshirt, it is 100% cotton and meant to be kept with mementos from a day you loved. I loved you today is a reminder to look at each day and find something to love in it.
I have been developing fashion branding and campaigns for 20 years - taking brands to international success, creating sketches and sayings, art directing, designing and creative directing photo shoots with renowned photographers and models. I loved everyday. Now I am pouring my passion into my own brand Pour l'air. Breaking all the rules I wish, making my own mess and writing my own story. I always used scent to get my mind to where it needed to be. I am fascinated with scent and the power of it so I spent time making scents of stories that you can get out of your head and into your dreams. Based on the science of scent affecting minds and moods, I write stories then work with highly skilled fragrance developers to make the stories into scents. Pour l'air scents are designed with purpose. They are designed to be an experience, to move your mind to hear your heart. Like a lover or a mother reading to you, they soothe and make the mind wander. They are made to pair with spaces to add poetry to the air.
MAME Soy Candles is a hand poured, hand blended and luxury soy candle company based in Phoenix, Arizona. Our candles are made from 100% soy wax and premium oils which allow them to burn longer and cleaner than most candles. We personally produce them in small batches to ensure the best quality handmade soy product. The candles are named and scented for some of our favorite things; these are things that personally resonate with shoppers who enjoy the scenery, memories and everyday beauty of life. Because the candles are made with pure soy wax, they burn much longer and much cleaner than other candles. And we promise you'll love them because they smell wonderful.
Minnie Rose is a luxury cashmere and knitwear brand that evokes a sophisticated yet playful attitude, attracting strong and successful women all over the globe.
Founded in 2005 by the iconic fashion visionary Lisa Shaller-Goldberg, who was the influence behind the success of beloved brands such as Juicy Couture, Ugg Australia, and True Religion. Minnie Rose has steadily proven their progressive vision for fashion while continuously cultivating the creative energy and passion that drives the brand.
The collection incorporates fresh, core wardrobe ingredients in the finest cashmere and softest cotton that become the basis of our client's ensembles. With a profound attention to detail, each season unveils an extensive compilation of layer-friendly cashmere and an assortment of effortlessly chic trend pieces. By combining boho-chic with vibrant, elegant styles, it is undeniable that Minnie Rose is an alluring brand in the typically classic luxury market.
Growing up in the suburbs of Los Angeles, my childhood smelled like oranges, tasted like avocado, felt like a perfect cannonball into a cool pool and every day looked like a new adventure. Whether it was making mud pies in the back yard, or playing with one of my family's many pets, a sense of cheerful exploration filled my early days. This set the stage for what would eventually become Chocolate and Steel.
My dad operated a family owned print shop and I was the lucky recipient of scraps of discarded projects that I turned into collages or clothes for my dolls. It was here, too, a seed was planted that would become a deep appreciation for small business and local products made with love.
My hobby became a full time business in 2008 after my son was born. I carved out a corner of our living room and set up shop. Chocolate and Steel has since grown into a small group of artisans and our dog Ninja with our very own studio. The studio is solar powered and we work with a small local LA casting studio. We take every care to maintain the integrity of American made products and processes with each step in crafting our jewelry.
Happy socks started in the Spring of 2008. Two friends had a vision: to spread happiness by turning an everyday essential into a colorful design piece with a rigid standard of ultimate quality, craftsmanship, and creativity. A concept now brought to perfection by the Happy Socks collective of creators.
Simply put: there's a pair of high-quality socks and underwear for every occasion, mindset, and style.
The Sage Lifestyle is home to Sage Machado's niche gemstone perfumery, natural candles and artisan jewelry. Sage opened her first flagship boutique in Los Angeles 25 years ago, which was devoted entirely to her one-of-a-kind jewelry and unique items from around the globe. Inspired by her love and passion of gemstones, her perfumery was born. Sage's fans quickly fell in love with her new addition, which continues to grow and flourish.
Book an appointment directly with our in house Recommended seamstress.


Have you always wanted to paint but did not know the first thing about it? Have you sketched thousands of pictures in your sketch book and wanted to put them on canvas? Now you can with the help of this book. We teach you everything to get you started in the wonderful world of fine arts. You can learn to express yourself with color.
Learn basic painting techniques. Understand lighting and shading. Learn how to choose your subjects. Determine which paints are right for you. Get a breakdown on all the brushes and what they are for. Learn why you should layer your paints.
How long have you sat there wondering if you have what it takes to put your creativity on canvas? Have you ever seen a painting and thought you could have done better? Do you have an urge to touch up the artwork in your house because you see flaws in the technique? We can help you.
Learn the different kinds of paint available. Understand the "Fat over Lean" rule. Find out where you can get the best art supplies. Learn to paint like a pro in no time.
This informative ebook will guide you through the steps of painting on canvas. You will discover who some of the great artists were. With the information in this book you can learn to paint just like them. Understand their techniques. Learn how to use references. Determine what is a good subject matter for you to paint.
How to determine where your light source should be. Learn how to carry it over to the rest of the painting. Understand what the shadows are for.
Which one is best for you? What is the difference? How do you store them? Which brand do you use?
You can have all the information in one neat package for only $17.00. This all inclusive guide will explain in simplified terms all the questions that have eluded you in your internet searches or textbooks on the subject.
Why spend hours going over outdated information that will leave you as clueless as when you started. Your time is money and it could be better spent reading just one informational source and spending the rest of your time painting.
Canvas Painting 101: Beginners Guide to Canvas Painting canvas painting;guide;tips 132323042 21.97 tablaqueen Fresh Download Available!


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Kid-sized versions of the world's best musicals.
Broadway Junior Downloads
Free Songs!
Download and listen to a song from each and every Broadway Junior™ musical.
Download all the KIDS songs! | Download all the JR songs!
"A Whole New World" - Disney's Aladdin JR.
"Zip-A-Dee-Doo-Dah" - Disney's Alice in Wonderland JR.
"It's the Hard Knock Life" - Annie JR.
"Be Our Guest" - Disney's Beauty And The Beast JR.
"Ziggy" - Dear Edwina JR.
"My Friend the Doctor" - Doctor Doolittle JR.
"Happy All The Time" - Elf the Musical JR.
"The She Goes!/Fame" - Fame JR.
"If I Were a Rich Man" - Fiddler on the Roof JR.
"Look to the Rainbow" - Finian's Rainbow JR.
"Bushel and a Peck" - Guys and Dolls JR.
"You Can't Stop the Beat (Part 1)" - Hairspray JR.
"We're All in This Together" - Disney's High School Musical JR.
"Different" - Honk! JR.
"Children Will Listen" - Into the Woods JR.
"Bend and Snap" - Legally Blonde JR.
"Under the Sea" - Disney's The Little Mermaid JR.
"I Like To Move It" - Madagascar JR.
"Stop Thief!" - Magic Tree House: A Ghost Tale for Mr. Dickens
"A Girl Worth Fighting For" - Disney's Mulan JR.
"The Wells Fargo Wagon" - The Music Man JR.
"Toys" - My Son Pinocchio JR.
"Mama Will Provide" - Once On This Island JR.
"You Can Fly/Fly to Your Heart (Part 2)" - Disney's Peter Pan JR.
"With Cat-Like Tread" - The Pirates of Penzance JR.
"Interjections" - Schoolhouse Rock Live! JR.
"Oh, the Thinks You Can Think" - Seussical JR.
"Singin' in the Rain" - Singin' in the Rain JR.
"Gimme Gimme" - Thoroughly Modern Millie JR.
"Friend Like Me" - Disney's Aladdin KIDS
"You're Never Fully Dressed Without a Smile" - Annie KIDS
"Scales and Arpeggios" - Disney's The Aristocrats KIDS
"The Work Song (Reprise)" - Disney's Cinderella KIDS
"Friend or Foe (Part Two)" - Magic Tree House: Dinosaurs Before Dark KIDS
"The Bare Necessitites" - Disney's The Jungle Book KIDS
"Seventy-Six Trombones" - The Music Man KIDS
"Alone in the Universe" - Seussical KIDS
"Once Upon a Dream" - Disney's Sleeping Beauty KIDS
"Winnie the Pooh" - Disney's Winnie the Pooh KIDS
"A Year with Frog and Toad (Opening)" - A Year With Frog and Toad KIDS
Mary Poppins JR.
Your favourite practically perfect nanny takes centre stage in this Supercalifragilisticexpialidocious adventure based on the award-winning Broadway musical and classic Walt Disney film.
Disney's High School Musical JR.
We're all in this together in Disney Channel's smash hit musical phenomenon featuring the students of East High.
ABBA's hits tell the hilarious story of a teen's search for her birth father on a Greek island paradise.
Adapted from the Disney film, New York City's newsboys seize the day when they strike against unfair working conditions.
Be Our Guest! The Academy Award-winning film comes to life in this romantic and beloved take on the classic fairytale.
The epic tale of broken dreams, passion and redemption is set against a nation in the throes of revolution.
"Oh, the thinks you can think" when Dr. Seuss's best-loved characters collide and cavort in an unforgettable musical caper!
Everyone's favorite ogre is back in the hilarious stage spectacle based on the Oscar-winning smash hit film.


From the second you walk in to CareOne at Holmdel, the appearance is excellent, along with the receptionist. I bring her flowers once a week because she is so pleasant. The food is above standard, the caretaking is good, and my wife is always kept clean. I tell my friends and family that although no one wants to be at a center, if you or a loved one should ever have the need I would say to send them to CareOne at Holmdel.


Studio Teresa Collins hand-tufted rugs express a love of colour, texture and abstract imagery. We make off the peg, customised and bespoke designs.
These contemporary classic are unique and a barefoot luxury.
My career over 25 years includes countless projects involving rugs, wall hangings and carpets. I am committed to innovative design, excellent quality, the finest materials and skilled British craftsmanship.


Jetstar will operate three flights per week on the new route from 3 August 2018, with 56,000 seats available on the route annually.
Jetstar has today announced new flights from Brisbane to Uluru (Ayers Rock Airport) will take off later this year, marking the first ever direct flights between the two destinations.
The low fares airline will operate three flights per week on the new route from 3 August 2018, with 56,000 seats available on the route annually.
Jetstar Executive Manager Alan McIntyre, said the airline expects strong demand from Queenslanders wanting to visit the red centre.
"Uluru is one of the most iconic destinations in Australia," Mr McIntyre said. "With Brisbane continuing to grow as one of Australia's largest tourism hubs, we are confident that our low fares will encourage more people to travel to the Northern Territory.
"Currently thousands of Queenslanders are travelling to Uluru via Melbourne, so not only will direct flights provide a lower cost link to central Australia, but also the flight time will only be around three hours.
Tourism Industry Development Minister Kate Jones said today's announcement was another win for Tourism in Queensland and would support up to 100 jobs a year.
"Through the Queensland Government's Attracting Aviation Investment Fund we've partnered with Jetstar to secure this new route and give thousands of tourists direct access to Brisbane from Uluru," she said.
NT Government Minister for Tourism and Culture, Lauren Moss welcomed the announcement: "The new three per week service will provide domestic and international tourists unprecedented access to the Red Centre and its rich cultural experiences.
Jetstar currently operates direct flights from Melbourne and Sydney to Uluru. The additional flights from Brisbane will see us offering up to 257,000 seats to and from Uluru each year.
To celebrate the announcement, Jetstar is launching a 12-hour sale with fares from $89 one way*.
*Jetstar sale runs on Wednesday April 11 from 12:00 AEDT to 23:59 AEDT. Select travel periods apply across November-December 2017. Sale fares not available on all flights or days. Terms and conditions will be on Jetstar.com from Wednesday 9 August, 2017.


With the winter weather we all tend to spend most of our time in our homes trying to stay warm. While sometimes curling up with a blanket and drinking coffee will do the trick, Service Experts Heating & Air Conditioning is here with some tips on how to stay warm (and safe!) this winter.
Make sure you have carbon monoxide (CO) detectors installed on every floor of your home, specifically near bedrooms, and test them to verify they are working. Since CO cannot be detected because it is odorless and invisible, it's vital that you have working CO detectors to make sure you are safe.
This is the right time of year to get the fireplace going, but before you do, be sure you have your chimney cleaned and checked by a professional. The fireplace may be a source of CO if you don't keep it regularly cleaned and maintained.
Space heaters are typically safe, energy efficient, and a helpful way to heat small sections of your home, but verify it has been sanctioned by a recognized testing laboratory and has an automatic shut-off feature. Observe all manufacturer's instructions and ensure it is placed on a hard, level surface at least 36 inches away from any flammable products.
With a Precision tune-up from Service Experts Heating & Air Conditioning in Longmont, we will perform a safety check of your heating system to be sure there are no leaks or CO problems. Along with a Precision tune-up, make sure your heating vents are free from obstruction and that you're replacing your air filter each month. This will prevent the air flow from becoming restricted and help prevent allergens from irritating respiratory issues.
There are correct ways and wrong ways to heat your home – using the oven, a grill, or a camp stove are all wrong ways. Using these devices to heat your home could cause a fire or a dangerous buildup of carbon monoxide. If you need support paying your energy bills, visit NeedHelpPayingBills.com to find a service close to you.
To ensure your home is ready to keep you safe and warm all winter long, call Service Experts Heating & Air Conditioning at 303-647-5749 today.


developed a comprehensive food safety system that ensures your pet's food is .Wolf King ® With Bison. Bison & Brown Rice Recipe With Sweet Potatoes ..
ensures your pet's food is .Wolf King ® With Bison. Bison & Brown Rice Recipe With Sweet Potatoes ..
delicious Rachael Ray dog food that both you and your dog will appreciate.Description.


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iPadOS 16.1 could arrive sooner than you think – but what about Stage Manager?
admin October 11, 2022 Uncategorized 0 Comments
After a delay and a rename to iPadOS 16.1, it's been alleged that the software update for iPads could arrive on October 24, six weeks after iOS 16 and watchOS 9 debuted.
It's an update that's regarded as one of the most important to come to Apple's tablet, and it's not just because of the weather app arriving. Stage Manager is the latest method to help you manage multiple apps at once, while also enabling external display support.
However, the feature has not only been updated to work on other iPads, but external display support has been delayed to a later release.
Yet there's plenty to enjoy from iPadOS 16.1 – so with this in mind, here's what should be arriving on your iPad by the time October ends.
What's included in iPadOS 16.1
iPadOS 16.1 is on track to be released the week of Oct. 24th — barring any new bugs or issues. Apple has historically held launches the week of its earnings calls in October.October 10, 2022
With Stage Manager heralding a huge change for multitasking on the iPad, we don't see a situation where October 24 arrives with iPadOS 16.1 and the feature is nowhere to be seen. It's a far too important an addition to be left out, so we're expecting it to arrive at the end of the month, albeit with some bugs.
However, while you can use what's also available in iOS 16 – such as the improved Mail and Messages features – there's a bunch of exclusive improvements that you can only take advantage of once iPadOS 16.1 arrives, such as the Weather app.
First debuting in iOS 14, the app is moving over to iPadOS and macOS Ventura, where it showcases an expanded layout, letting you look at more information, such as predicted rain, detailed maps for temperature and more.
There's also an effort by Apple to make each of its iPad apps 'desktop class', which means adding menus that you can easily access for features and shortcuts that are otherwise inaccessible on iOS.
With October 24 fast approaching, there's going to be a feature in iPadOS 16.1 that you'll find useful at least, but it depends on how Stage Manager will debut.
Tagged arrive, iPadOS, Manager, sooner, Stage
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Ant-Man has been getting early praise from critics and fans, who call it the "most human Marvel film to date." But even with the overall warm reception to the script, the most positive attention is arguably going to Ant-Man's apparently plentiful MCU connections.
Early screenings confirm there are two "huge" post-credits scenes, as well as miscellaneous Easter eggs and MCU cameos. Now, a new TV spot not only confirms that an Avenger will make an appearance, but briefly shows which Avenger it will be.
The TV spot, which seems to highlight positive critical reviews, doesn't give any insight as to why Falcon is there. But we can only assume that he was called in to help, since it was implied in a previous TV spot that the Avengers are unavailable to assist Ant-Man with his struggle against Yellowjacket in the current MCU timeline.


There are way too many people around us with up to not good in any way. To keep them thoroughly protected, we need to install one of the most proper security and locking systems and mechanisms done only through the professionals. We definitely would make sure that any of our properties' locks can't be picked, bumped and are resistant to break ins. What's great is that we can always seek for help by contacting professionals in locksmithing. Licensed locksmith technicians who have locksmithing expertise provides any assistance we require starting from locked out troubles, security issues at home, office or in our car, or even as simple as a basic fix on the locking mechanism.
Making sure that our family, valuables and cherished properties are well guarded is our responsibility. It's good to know that there are reliable and efficient locksmith service providers that we could turn to when we are in need. Regardless of what locksmith problem you are encountering, it can be a residential, automotive or commercial locksmith dilemma; you can truly depend on a reputable locksmith expert.
We are a company available no matter what time. This includes nights, weekends, and holidays. All commercial, residential and automotive clients can benefit to the wide range of services we offer. We make sure to satisfy you with the use of the most advanced locksmith technology. Safety and security remain our top priority. Act now or you will be sorry later. Our customer service support can answer all of your concerns. Do not waste your time for nothing, call us right away!


In today's Gospel, we hear of a "large number of people" who came to "hear Jesus and be healed of their diseases." We can see that it is the people's desire for healing that first draws them to Jesus. With that, today's Gospel can be seen as an invitation to all of us to recall what first drew us to Jesus. In the case of the twelve Apostles, it was the explicit calling of their names by Jesus. In the case of other disciples, it was their desire for healing.
Each Christian will have a personal story of what first drew him or her to Jesus. Perhaps it was an encounter with Scripture. Perhaps it was seeing the faith of a friend or family member. Perhaps it was even the witnessing of a miracle. Whatever the case may be, today's Gospel invites us to recall what first drew us to Jesus, and to thank him for it.


It was a different time, says Carol Collins Cole, DIP P&OT'54, BSc (P&OT)'55, of her years at McGill, when uniformed waiters still served lunch and dinner to students in residence.
It was also the height of a polio epidemic that would leave an estimated 11,000 Canadians paralyzed. Cole remembers provincial governments from across the country sending new high school graduates to study at McGill—one of Canada's only two universities with a physical and occupational therapy program—to learn to care for those crippled by the disease.
Cole and a classmate were the first to earn BSc degrees from the School of Physical & Occupational Therapy (SPOT). As a McGill student and then as a graduate working in Montreal, she practised physiotherapy on many, including refugees, veterans, pregnant women, miners and sailors. One miner from Sept-Îles, treated for a broken neck, gave her a gold nugget that she still has today.
Her path to McGill began in Grade 9 in Schenectady, New York, where she befriended a hospitalized teen with polio who had to wear a corset and leg braces. "I wanted to help people who were in that situation to get better," she says, adding that performing charitable deeds had always been an important part of her family, school and church life.
Cole decided to study physiotherapy. She looked at the program offerings in New York City and Boston, but both required her to study physical education or nursing, or to already have a bachelor's degree. Once she saw that the SPOT curriculum would allow her to concentrate more closely on physical and occupational therapy, she made up her mind. Soon enough, her grandmother was writing a cheque for her first year's tuition and she was shipping her trunk to Montreal.
It was September 1950, and, at 5'9" and wearing clothes her mother had sewn, the small-town teen felt intimidated by the backgrounds of some of her new peers when she arrived at her residence, Royal Victoria College (RVC). Amongst them were the daughters of a food magnate and of a former governor general. Such worries quickly dissipated, though, as residence life brought together students from around the world and of different means.
One RVC memory has Cole standing on its Sherbrooke St. steps (now the Schulich School of Music) with her fellow residents and curtsying for an open-air limousine passing by, carrying the then-Princess Elizabeth.
SPOT was located up the hill on Pine Ave. in a former Golden Square Mile Edwardian mansion, Beatty Hall. Cole attended lectures held in the ballroom and a dark wood panelled billiard room. She had massage therapy classes and learned how to use electrodes to stimulate muscles. Under the Occupational Therapy curriculum, she studied sewing and weaving as well as metal and wood work.
Cole loved discovering Montreal. She would travel by street car and then bus to Verdun Protestant Hospital, now the Douglas Mental Health University Institute, to treat psychiatric patients. She still remembers reading the sign on the street car: Défense de cracher sur le plancher (No spitting on the floor). She can also still recite the French she used in physiotherapy: Toussez s'il vous plait (please cough) and Pliez les genoux (bend your knees).
Between her third and fourth year, she interned in Alberta, "hot-packing" polio patients to relieve muscle spasms. The Salk vaccine came out that same year and conquered polio.
Her parents convinced her to take a fifth year at the School to earn its newly offered bachelor of science degree. She and a fellow student struggled through Physiology but were saved, she says, by a young Phil Gold, BSc'57, MDCM'61, MSc'61, PhD'65, co-discoverer of the carcinoembryonic antigen (CEA), still used widely to test for cancer today. "He helped us with these frogs, where you had to cut their spinal cords." She remains thankful for his kindness.
In 1953, in her starched white uniform with velvet green striped cap, she would travel to the Montreal General Hospital, which was then located on De la Gauchetière St. Each ward contained forty beds. She would have to drag the large privacy screens from the nurse's desk. She remembers that one of her patients was a Chinese sailor injured at port. She also treated Hungarian refugees, some grappling with the aftermath of shrapnel wounds, at the now-defunct Queen Mary Veterans Hospital, where she secured a staff position after graduation.
In 1957, she married George Cole, MDCM'57, a day after his graduation. They had met in 1954 and had discovered that they both had attended high school in Schenectady.
They moved to the United States and would eventually settle in Minnesota. She continued in her career until starting a family, eventually raising four children. She and her husband would later volunteer every year in Haiti and, since his passing, she has been an avid traveller.


The wreckage of a British tank beside the Menin Road near Ypres.
Bullets flew past the 20-year-old soldier as he stormed towards enemy machine gunners.
It was the first day of the Battle of Passchendaele, a World War 1 campaign which would become infamous not only for the scale of casualties, but also for the mud.
But on that day Private George McIntosh's bravery earned him a Victoria Cross (VC).
Born in Fraserburgh, before moving to Buckie aged 12, Pte McIntosh fought with North-east regiment the Gordon Highlanders.
The young soldier received the highest award for bravery for saving the lives of his comrades under heavy machine-gun fire during the conflict near Ypres in Belgium.
Pte George McIntosh stormed forward to attack the enemy, saving British lives.
Pte McIntosh stormed forward and threw a Mills grenade into a German emplacement, killing two of the enemy and wounding a third. He then entered the dugout and found two light machine guns, which he carried back with him.
Pte McIntosh went on to serve in World War 2 and was 68 when he died.
His medal was sold at a London auction in 2006, fetching £36,800.
The successful bid was made by an anonymous collector and was more than double what auctioneers Spink of St James's had expected.
It also far exceeded what the Gordon Highlanders Regimental Museum in Aberdeen could afford in its attempt to keep the medal in the North-east.
But this Friday the museum will hold a re-enactment to commemorate his bravery.
It is being held to mark the start of a tour honouring the regiment's 19 recipients of the VC.
Members of the Regimental Association will be joined by distinguished guests to launch the programme of events which will take place in schools across the North-east.
Members of The Great War Boys, one of Scotland's leading re-enactment groups, will recreate Pte McIntosh's charge. Together with museum staff they will also give a presentation telling the story of all 19 Gordon Highlanders who, since the award's inception in 1856, have been awarded this honour.
Mike McDonald, Gordon Highlanders VC Commemorative Secretary, said: "The museum, where so much of the regiment's fine history is now conserved and on display was the ideal place to launch such a tour which will lead up to the main commemoration in July.
"In organising this tour, the Gordon Highlanders are returning to their roots.
The tour will go to Fraserburgh on February 24, Huntly on April 21, Turriff on May 26 and Aberdeen on a date to be confirmed.
It will culminate at the Commemorative Parade and Gathering at Buckie on July 19.


text:
Dallas Summer Musicals not only presents, but produces and invests in Broadway shows. Because of our strong involvement with musical theatre on and off Broadway, we have been fortunate to receive the following awards and nominations:
Awards Received: 25
Nominations: 60
DRAMA DESK AWARDS
Awards Received: 9
OLIVIER AWARDS
Nominations: 4
OUTER CRITICS CIRCLE AWARDS
Boeing - Boeing
2 MORE TONY AWARDS® FOR Dallas Summer Musicals:
BOEING – BOEING! PRODUCED IN PART BY DALLAS SUMMER MUSICALS
"BEST REVIVAL OF A PLAY" WINNER!
"BEST PERFORMANCE by a LEADING ACTOR in a PLAY" WINNER!
Read the NY Times review here. Official website here.
Nominated for Six Tony Awards® & WINNER of Two! Play revival produced in part by Michael Jenkins, Dallas Summer Musicals
"We're thrilled to announce that Boeing-Boeing has been nominated for six Tony Awards®," said Michael Jenkins, President and Managing Director, Dallas Summer Musicals. "Dallas Summer Musicals has played a huge part in producing this hilarious play revival on Broadway and we look forward to the awards announcements on Sunday, June 15th."
Boeing-Boeing was nominated for these TONY AWARDS®:
* Best Revival of a Play; * Best Performance of a Leading Actor in a Play: Mark Rylance * Best Performance by a Featured Actress in a Play: Mary McCormack * Best Direction of a Play: Matthew Warchus * Best Costume Design of a Play: Rob Howell * Best Sound Design of a Play: Simon Baker
Also in June 2007 Jenkins and Dallas Summer Musicals were bestowed with the incredible honor of winning the 2007 Tony Award® for Best Special Theatrical Event for Jay Johnson: The Two and Only.
BOEING-BOEING When BOEING-BOEING took off to a roar of laughter in 2007, it was crowned "The funniest show on the London Stage" by the Daily Telegraph and quickly became the first-class champagne toast of the town. Now this Olivier and Evening Standard Theatre Award-nominated production of the classic comedy is coming in for a landing on the Great White (Run)Way!
The new Broadway cast Includes Tony® and Emmy® Award winner Christine Baranski ("Cybill"), Emmy® winner Bradley Whitford ("The West Wing"), Gina Gershon ("Ugly Betty"), Kathryn Hahn ("Crossing Jordan") and Mary McCormack ("The West Wing"). Reprising his star turn as Robert is acclaimed British actor Mark Rylance.
In BOEING-BOEING, Bernard, an architect living in Paris, has been successfully juggling three fiancées who are all flight attendants. Bernard's housekeeper reluctantly plays romantic air-traffic controller as they fly in and out of his swank bachelor pad. But when an old college pal visits, things get rather turbulent! Schedules change, flights are delayed and chaos ensues in this hysterical, high-flying fiancée fiasco!
Jay Johnson: Two And Only
An Award for Excellence – Michael Jenkins Brings the Tony® Award Home to Dallas! Video of acceptance speech beneath photo
Dallas Summer Musicals, presented by Comerica Bank, is proud to have been bestowed with the incredible honor of winning the 2007 Tony Award for Best Special Theatrical Event for Jay Johnson: The Two and Only.
The Tony Awards are Broadway's longest-running salute to theatrical excellence, both on stage and behind the scenes. On June 10, Tony Night was a celebration of the Best of Broadway. So, it was only fitting that DSM's President and Managing Director, Michael A. Jenkins, joined the esteemed group of Broadway and Hollywood stars on stage to bring not just one, but two medallions back to Big D! Mr. Jenkins accepted a Tony Award both on behalf of DSM and for himself as a producer of the award-winning show. The DSM medallion is proudly showcased in the lobby of its rightful home at The Music Hall at Fair Park.
As a visionary leader in Dallas' entertainment community, Jenkins' has consistently brought the "Best of Broadway" to Dallas Summer Musicals. This season, will be no different with a sensational line-up featuring more shows than have ever been offered in the organization's history.
To kick off the season, DSM will bring the Tony Award winning production of Jay Johnson: Two and Only to Dallas as the first show in the Broadway Contemporary Series.
Producers: Roger Alan Gindi, Stewart F. Lane & Bonnie Comley, Dan Whitten, Herbert Goldsmith Productions, Ken Grossman, Bob & Rhonda Silver, Michael A. Jenkins/Dallas Summer Musicals, Inc., WetRock Entertainment
About The Tony Awards The Antoinette Perry "Tony" Awards are bestowed annually on theatre professionals for distinguished achievement. The Tony is one of the mist coveted awards in the entertainment industry and the annual telecast is considered one of the most prestigious programs on television. The Tonys are presented by the League of American Theatres and Producers and the American Theatre Wing.
About the Medallion In 1949 the designers' union, United Scenic Artists, sponsored a contest for a suitable model for the award. The winning entry, a disk-shaped medallion designed by Herman Rosse, was initiated that year at the third annual dinner. It continues to be the official Tony Award.During the first two years of the Tonys (1947 and 1948), there was no official Tony Award. The winners were presented with a scroll and, in addition, a cigarette lighter (for the men) or a compact (for the women).
Since 1967 the medallion has been mounted on a black pedestal with a curved armature. After the ceremony, each award is numbered for tracking purposes and engraved with the winner's name.


Auto Windscreens is delighted to have been shortlisted in the Brake Fleet Safety Awards 2017.
The ceremony, taking place at The Hilton Birmingham Metropole on Thursday 28 September, will see the windscreen repair and replacement provider looking to take the top prize in the Fleet Safety Innovation category.
The awards run by Brake, the road safety charity, recognise the achievements of those working to help reduce the number of road crashes involving at-work drivers.
Rupert Armitage, Managing Director of Auto Windscreens commented on the news: "We are delighted to have been shortlisted in the innovation category this year. It's fantastic to be recognised for our ongoing work and commitment to supporting our fleet clients and the industry".


Sudan's new military rulers on Sunday rejected a demand by protest leaders to hand over power immediately to a civilian government that will bring deposed leader Omar Al-Bashir to justice.
"The Sudanese Professionals Association calls on its supporters to continue with the sit-in until the revolution achieves its demands". He was arrested the following year on suspicion of involvement in a coup attempt but was later pardoned by al-Bashir, who appointed him intelligence chief in February 2018.
A 10-member delegation representing the protesters held talks with the council and delivered their demands on Saturday, the Alliance for Freedom and Change said. The UAE said it welcomed the swearing-in of General Abdel-Fattah Burhan on Friday as head of that council.
"We surely want our demands to be met, but both sides will have to be flexible to reach a deal", said a demonstrator who spent the night at the army complex.


"The church is supposed to be the lobbyist of the poor, and the church has given up on its calling and resigned itself to a powerless position. We've sort of forgotten that for a long time. These are some of the signs that we''re stepping up. We need to reclaim that heritage." Shanta Premawardhana, president of the Seminary Consortium for Urban Pastoral Education in Chicago, on clergy engaging people of faith in conversations during the upcoming NATO Summit about why they should work to end poverty, world hunger, and war.
1. Top nine reasons Congress is broken.
Nearly three dozen D.C. insiders recently gathered at the Woodrow Wilson International Center for Scholars to discuss why Congress isn't working. From that conversation comes this list of the nine toughest problems facing Congress today.
2. Budget time bomb sends shivers across economy.
3. Over 55 and jobless, Americans face tough hunt.
The number of long-term unemployed workers aged 55 and older has more than doubled since the recession began, and their chances of reentering the workforce are grim.
4. A generation hobbled by the soaring cost of college.
Nearly everyone pursuing a bachelor''s degree is borrowing money, and as prices soar, a college degree often comes with an unprecedented financial burden.
5. Pakistan signals end to blockade of Nato supplies.
Top Pakistani leaders will on Tuesday (today) discuss ending a blockade of foreign military supply routes into Afghanistan and repairing US relations, signalling a rapprochement ahead of a Nato summit.
6. Iran sees success in stalling on nuclear issue.
7. Syria's resurgent Muslim Brotherhood.
After three decades of persecution that virtually eradicated its presence, the Syrian Muslim Brotherhood has resurrected itself to become the dominant group in the fragmented opposition movement pursuing a 14-month uprising against President Bashar al-Assad.
8. Palestinian prisoners end hunger strike.
9. Africa must boost food output.
The United Nations Development Programme says Africa needs to boost agricultural productivity if it is to sustain its economic boom. … But it says sub-Saharan Africa cannot sustain its present economic resurgence unless it eliminates the hunger that affects nearly a quarter of its people.
Hollande sets out growth agenda.
New French President Francois Hollande called for a European pact for growth to balance out German-driven austerity measures in his inaugural address on Tuesday.
Merkel won't budge on austerity.
Europeans hoping that mounting international opposition will make her drop her austerity plan to save the euro -- a policy that is causing so much pain in ailing economies like Greece and Spain -- are likely to be disappointed.
Political deadlock in Greece rattled world markets Monday, reviving fears that the fractious Mediterranean country could spurn an international bailout, abandon the common European currency and risk a fresh round of world economic turmoil.


What is an OCT eye test – and what does it do?
Cascadia Eye has an OCT device at five of our locations. But unless you have glaucoma (or a family history of it), macular degeneration, or diabetic retinopathy, you may never have seen this amazing piece of technology at work. And if you have received an OCT test before, now you can find out what it actually does, and how!
It's not just the abbreviation for October – in ophthalmology, OCT stands for Optical Coherence Tomography. At its most basic description, the OCT "takes pictures of the back of your eye." From a patient standpoint, this simply means you sit at the machine and place your head as directed, and shortly thereafter the technician tells you they have the images they need and you go on to the next portion of your eye exam. But it's so much more than that.
The best description I've heard for how the OCT functions is that it's like an ultrasound, except it uses laser light* – instead of sound waves – to map the shape of the retina and optic nerve. It's non-invasive and not destructive to tissue; a camera-like device directs the waves of light, which bounce back with an accurate 3-D picture.
So what do these colorful pictures mean? A doctor looking at the above image knows what a healthy retina and optic nerve will look like – how thick and/or even it should be, and more. Because the OCT's map of the eye is in 3-D, doctors can detect areas of the eye that are abnormal or damaged early on (for example, if they have a blister of fluid in a layer of the retina), before it has affected the vision of the patient. Early detection means we can treat diseases like glaucoma, or halt the progress of macular degeneration, before they cause irreversible vision damage.
For a (somewhat amusingly) dated – but informative – look at the OCT when it first came out, you can also watch this video. The technology has gotten even better since then; it is also much more widespread in its use, which is a wonderful thing!
If you would like to learn more about the OCT, or if you would like to schedule an appointment at Cascadia Eye, please contact us today. We are happy to answer any questions you might have!
*The light is actually a 'laser-like' light source known as a super luminescent diode (SLD).


Does One Month Make A Difference?
After 3 lab works, my doctor thinks I should start a treatment.
For certain reasons it would be convenient for me to start it one month later. He says its up to me (as always) BUT he strongly believe that I shouldnt wait. My CDs are pretty much ok (he says), round 700, but VL is high 100,000.
My question is: does that one month of postpone makes that much difference?
That last time he saw me he wanted to do my general physical check up. For some reasons he didnt, and now I have an appointment with the pharmacist next week AND another meeting with the doctor in almost 4 weeks when hes going to perform those tests. My question is: are those tests relevant regarding starting medication, choosing a right combinationkidney parameters, liver parameterscholesterol?
Thank you very much for your answers and your time.
Hello Nik and thanks for your post.
While I generally consider HIV medications for the majority of my patients, there's little harm in waiting a month to start (especially if you're asymptomatic and have a CD4 count of 700).
We do look at a wide variety of factors, including the health of liver and kidney prior to the selection of medications, so having this information at the time of deciding on which medications to use is valuable.


text:
Project Acronym: CoaBrush_I
Title: Conformational and Dynamic Properties of Short DNA Minicircles in Aqueous Solution from Atomistic Molecular Dynamics Simulations
Pi: Vlasis G. Mavrantzas
Conformational and Dynamic Properties of Short DNA Minicircles in Aqueous Solution from Atomistic Molecular Dynamics Simulations
by T. S. Alexiou, P. V. Alatas, D. G. Tsalikis, V. G. Mavrantzas
Detailed molecular dynamics (MD) simulations of aqueous solutions of short DNA minicircles ranging in size from 30 to 180 bp were performed for the investigation of the structure and dynamics at an atomistic level, by employing the recently developed parmbsc1 force field. The resulting MD trajectories were analyzed for the determination of local conformation in terms of backbone torsion angles and interbase pair helical parameters, and very good agreement was observed with respect to relevant experimental data. Minor groove hydration exhibits a bimodal structure for all nucleobases, with water molecules residing in the first subshell of hydration forming a highly ordered, chiral water layer that conforms to the topological state of DNA, even adopting a twisted, figure-eight shape in the case of 180 bp minicircles. The mean-squared radius of gyration of the simulated DNA minicircles was found to scale with the number of base pairs, Nbp, as ⟨Rg2⟩ ∼ Nbp2ν with ν ≈ 0.83, a scaling exponent in-between the values corresponding to a rigid rodlike behavior and the 3D self-avoiding walk limit for flexible chains. Ultrashort and very stiff 30 bp minicircles exhibit an unexpectedly pronounced degree of anisotropic diffusion, a phenomenon that is attenuated as the molecular length increases due to the emergence of out-of-plane bending motions.
Conformational and Dynamic Properties of Short DNA Minicircles in Aqueous Solution from Atomistic Molecular Dynamics Simulations (T. S. Alexiou, P. V. Alatas, D. G. Tsalikis, V. G. Mavrantzas), In Macromolecules, volume 53, 2020.
@article{doi:10.1021-acs.macromol.0c0082,
author = {T. S. Alexiou, P. V. Alatas, D. G. Tsalikis, V. G. Mavrantzas},
doi = {10.1021/acs.macromol.0c0082},
url = {https://doi.org/10.1021/acs.macromol.0c00821},
journal = {Macromolecules},
pages = {5903-5918},
title = {Conformational and Dynamic Properties of Short DNA Minicircles in Aqueous Solution from Atomistic Molecular Dynamics Simulations},
abstract = {Detailed molecular dynamics (MD) simulations of aqueous solutions of short DNA minicircles ranging in size from 30 to 180 bp were performed for the investigation of the structure and dynamics at an atomistic level, by employing the recently developed parmbsc1 force field. The resulting MD trajectories were analyzed for the determination of local conformation in terms of backbone torsion angles and interbase pair helical parameters, and very good agreement was observed with respect to relevant experimental data. Minor groove hydration exhibits a bimodal structure for all nucleobases, with water molecules residing in the first subshell of hydration forming a highly ordered, chiral water layer that conforms to the topological state of DNA, even adopting a twisted, figure-eight shape in the case of 180 bp minicircles. The mean-squared radius of gyration of the simulated DNA minicircles was found to scale with the number of base pairs, Nbp, as ⟨Rg2⟩ ∼ Nbp2ν with ν ≈ 0.83, a scaling exponent in-between the values corresponding to a rigid rodlike behavior and the 3D self-avoiding walk limit for flexible chains. Ultrashort and very stiff 30 bp minicircles exhibit an unexpectedly pronounced degree of anisotropic diffusion, a phenomenon that is attenuated as the molecular length increases due to the emergence of out-of-plane bending motions.},


So why does the US draw a disproportionate number of foreigners to its college campuses?
The American research university is arguably the world's most powerful engine of innovation and discovery. Most young students like to study in such a setting and be a part of the next big thing.
Dr. Jonathan Cole of Columbia University maintains a list of the great contributions of US universities to every day living. Can you really imagine modern life without the following discoveries that we all now take for granted? [And mind you, this is just a partial list. For the full list, check references at the bottom of this post].
If you want even more inspiration about how academics meets the world of industry, please take the time to read this superb New York Times profile of Dr. Robert Langer of MIT. A chemical engineer by training, Dr. Langer has helped start 25 companies and has 811 patents, issued or pending, to his name. That's not too far behind Thomas Edison, who had 1,093. More than 250 companies have licensed or sublicensed Langer Lab patents.
Pursuing higher education opportunities in the US can truly change your life. And you don't have to attend any of the schools listed on this page either.
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