Tiny Code: Floppy booting, Open Firmware, Bitlash, more Movizt.
Floppy booting, Open Firmware, Bitlash, more Movizt.
As a child, I was fascinated by small, intricate things. Wind up clocks and tree seeds were two of my favorites. This continues through my programming. I take a certain pride in making something small, reliable and easy to comprehend. I also take it a bit further than most. Even in college, while surrounded by engineers (who usually like pragmatic elegance), I was teased for writing a dozen three line functions when my classmates used a single 100 line main.
Similar minimalistic styles can be found in artwork, literature and music. These styles are often enforced by the medium. Ink drawings only use crisp lines. Haiku will never ramble on. Saxophones don't play chords.
Sometimes the tools themselves are simple. An ink pen is pretty simple. However, the full interplay of language available to the poet is beyond a single person's understanding. As for music, you know how complicated a saxophone is if you've ever repaired a broken spring deep in the works.
There is a certain appeal in closing the meta-loop of minimalism in programming. Writing simple, efficient code in languages which themselves are simple and efficient. To that end, I've collected programming environments which are small and self contained, while still useful.
Side note: many of these are for x86 linux. If you don't have linux, find almost any old flash drive or memory card. Install Tiny Core Linux to it. Enable USB booting on your computer. Tiny Core is 10 megabytes and uses a highly modular packaging system. There is a copy on the boot partition of every computer I own, for the two or three times a year when I brick a primary partition. Tiny Core is actively maintained and dead simple to extend. It is a good fit with philosophy of minimalism.
Side note two: several of these are bootable floppies. Such disks and drives are a rare breed today, so boot the images with grub. The same trick works for LILO, too. Basically this copies the image to memory, then executes it. There is one downside, changes to the ram disk will not be saved back to the disk image.
amforth is probably the gem of this collection. All you need is a serial connection to begin programming high level embedded applications.
Tiny C Compiler is a very small compiler that very quickly compiles very small x86 binaries. Available for Linux and Windows, use it to build many of the following applications.
Caml Light compiles for windows and unixes. The entire system is about 200kb.
dream Scheme is an R4RS compatible Scheme written in x86 assembly. There are versions for Linux, Windows, and bootable floppy.
Gofer (GOod For Equational Reasoning) is a subset of Haskell 1.2. Very small, very fast, but no GC.
jonesforth is a literate x86 assembly tutorial and forth environment. Public domain, too.
joy is an odd little language. It feels halfway between Forth and Factor. But throw in single assignment and Lisp-style code manipulation, while replacing every flow control statement with combinators.
Needs K as a backend?
Little Smalltalk v3 has a non-graphical Smalltalk REPL in 40K. V4 segfaults a bunch, and v5 was biggish.
mini Pico Lisp is basically Pico Lisp but without any libraries.
Movitz is a small (almost) ANSI complete Common Lisp which runs on bare x86. The floppy image works well, but I had some issues with screen width. Asteroids and emacs are available on archive.org, but I haven't tested these yet.
Open Firmware provides a Forth environment and a lot of hooks into your system. The build instructions do not match the current directory layout, but you can figure it out.
Oxford Oberon-2 is the smallest Oberon compiler around. Building from source is a little convoluted, but works on Solaris, Linux, Windows.
SmartEiffel Compiles to C or JVM bytecode. I recommend version 1.1, or the pre 1.0 SmallEiffel.
TinyScheme is mostly R5RS. See the site for optional goodies like sockets, filesystems and regular expressions.
Some of these are not programming languages. Some are languages, but don't run on the metal themselves. Some of them are clever toys, but not useful. Some are redundant. Some are useful, but also comparatively big. Some look awesome, but I don't have the hardware for proper experimentation. They still deserve mention, and if your tastes differ from mine, may even be exactly what you are looking for.
a-Linux has a 532 byte http server.
BashForth is a portable, no install atrocity.
bitlash fixes one of my complaints about the Arduino, by providing an interactive shell.
Bluebottle is the very modern OS built on Oberon-2.
Chaos Linux is a 6Mb distro for clusters.
Dreams is a message-passing Forth.
GTK-server can easily give any little program a GUI.
Hedgehog Lisp "Never underestimate the power of a small tactical Lisp interpreter."
IOCCC x-lisp is a tiny lisp interpreter, which stores all it's data structures as strings.
IoL4 merges the IO language and L4 microkernel. Very buggy.
Language Zoo contains several different styles of languages written in OCaml.
Lua is a common application scripting language.
MinForth provides windows, linux, dos and source versions.
OCaml Mindstorm runs on the second generation brick, the NXT.
pbForth for RCX is a nifty interactive Forth for the Lego Mindstorms.
pbLua offers a complete toolchain and is actively developed.
Pico Lisp is a very complete lisp system, with many libraries.
picoOS supplies a small real time operating system for several platforms.
smlisp almost made the cut, but the Modula3 library kills its size.
TFLC is a very small and experimental Haskell engine.
tinypy is missing all of my favorite features.
uBASIC is the only Basic listed here, and only then because it was written by the brilliant guy behind uIP.
XS for RCX is a Lisp shell for Lego Mindstorms.
It has been surprising hard finding a single floppy linux which provides more than BusyBox shell scripting. Surprisingly, Tomsrtbt has Lua!
But I don't have any 64 bit chips to try it out on.
Quest for the smallest Java VM, http://www.harbaum.org/till/nanovm/ is the leading contender.
Jim is an 85KB TCL interpriter.


text:
Q: How to include a class in CakePHP 2.x This is a very basic question but I can't figure it out.
I have a class that could be named myClass.php, this is a standalone PHP script that contains a standard object definition like this:
<?php

class myClass
{
  public function myFunction($param1, $param2){
    return $param1*$param2;
  }
}

All I want to do is to be able to call to this class from a model, this is from App/Models/MyModel.php be able to simply do $myClass = new MyClass();
Where should I store myClass.php in the file structure and how can I make it visible for MyModel?
Thanks!

A: You'll note that you have a 'vendors' directory inside the root (ie, on the same level as the 'app' folder). This is for placing non-CakePHP related files that are shared across applications. You also have an 'app/Vendor' directory, which is for storing non-CakePHP files that are specific to that one app.
So, it should go in one of these two directories - most likely, in app/Vendor.
There's a little bit to know about loading vendor files - you can read the details here.
In your case, you probably just need:
App::uses('myClass', 'Vendor');

redpajama_set_name: RedPajamaStackExchange


text:
Roseisle Distillery
The Roseisle area is home to woodland walks, miles of sand and the remnants of wartime defences along Scotlands northern shore. Hidden away from the tourist trails, this new operation from Diageo points towards a gleaming, mechanized future of malt production with nair a hint of Victorian ornamentation on its structures.
The first spirit ran in 2009 from Roseisle's stills. It has operated consistently since. It's not uncommon for a distillery to produce multiple styles of Whisky. Rarer, perhaps, for one to be designed expressly for such a purpose.
Roseisle has seven pairs of stills, six of which can switch between stainless or copper shells and condenser. To produce a light, vegetal make, a long fermentation can run in excess of 90 hours.
At the same time a heavy spirit can be produced elsewhere, by shortening mashing and fermentation regimes. The versatility of the equipment lined up at Roseisle, will allow Diageo to produce a variety of expressions at any given time.
Diageo Roseisle Distillery Elgin, Moray IV30 5YP United Kingdom

redpajama_set_name: RedPajamaCommonCrawl


text:
3 Ireland to launch 4G services
Sophie Donoghue
Hutchison Whampoa subsidiary 3 Ireland has announced that its 4G services will go live next week, on January 27.
Its 4G network will offer over 60% coverage in the cities of Galway, Limerick and Waterford and 40% in Dublin and Cork.
With Vodafone and Meteor launching their LTE services before Christmas, 3 Ireland is the third Irish operator to launch 4G.
Hutchison's Irish subsidiary is in the process of acquiring Telefónica's O2 Ireland for a reported $1 billion (€780 million). The deal is still subject to regulatory approval.
News ServicesWireless/MobileEnd UserEuropeNewsServicesInfrastructure and NetworksInfrastructure and Networks


text:
Q: Django - strptime() argument 1 must be str, not None In my application user is entering his name, email, meeting date and meeting hour and I want to save all these information to my database. But application is not running. I'm getting TypeError: strptime() argument 1 must be str, not None but don't what is the reason. Everything seems like true.
models.py:
def index(request):
    context = {
        'schedules': Schedule.objects.all()
    }

    participant_name = request.POST.get('name')
    participant_email = request.POST.get('email')
    meeting_date = request.POST.get('date')
    meeting_hour = request.POST.get('hour')
    converted_meeting_date = datetime.strptime(request.POST.get('date'), "%m-%d-%Y")
    converted_meeting_hour = datetime.strptime(request.POST.get('hour'), "%H:%M")
    if request.POST.get('participant_email'):
        Schedule.objects.create(
            participant_name = request.POST.get('name'),
            participant_email = request.POST.get('email'),
            meeting_date = converted_meeting_date,
            meeting_hour = converted_meeting_hour
        )
    return render(request, 'index.html', context)

models.py:
class Schedule(models.Model):
    participant_name = models.CharField(max_length=100)
    participant_email = models.CharField(max_length=100)
    meeting_date = models.DateField()
    meeting_hour = models.TimeField()
    is_scheduled = models.BooleanField(default=False)

    def __str__(self):
        return self.participant_name

A: You need to check if both meeting_date and meeting_hour are not None and also you need to convert them into string before applying strptime to them.
def index(request):
    context = {
        'schedules': Schedule.objects.all()
    }

    participant_name = request.POST.get('name')
    participant_email = request.POST.get('email')
    meeting_date = str(request.POST.get('date'))
    meeting_hour = str(request.POST.get('hour'))
    converted_meeting_date = datetime.strptime(request.POST.get('date'), "%m-%d-%Y").date() if meeting_date else None
    converted_meeting_hour = datetime.strptime(request.POST.get('hour'), "%H:%M").time() if meeting_hour else None
    if request.POST.get('participant_email'):
        Schedule.objects.create(
            participant_name = request.POST.get('name'),
            participant_email = request.POST.get('email'),
            meeting_date = converted_meeting_date,
            meeting_hour = converted_meeting_hour
        )
    return render(request, 'index.html', context)


John Lloyd Ackrill, FBA (30 December 1921 – 30 November 2007) was an English philosopher and classicist who specialized in Ancient Greek philosophy, especially the philosophy of Plato and Aristotle. Ackrill has been said to be, along with Gregory Vlastos and G. E. L. Owen, "one of the most important figures responsible for the upsurge of interest in ancient Greek philosophy among Anglo-American philosophers of the second half of this century".
Ackrill was born, to Frederick William Ackrill and Jessie Anne Ackril, in Reading, Berkshire where he attended Reading School.
In 1940 he entered John's College, Oxford, as a scholar in Classics where his philosophy tutors were Paul Grice and John Mabbott.The next year he left for war service in the Royal Berkshire Regiment and General Staff, reaching the rank of captain. He returned to Oxford in 1945 to read Literae Humaniore, graduating in 1948. He then accepted a teaching position as assistant lecturer in Logic at Glasgow before being appointed university lecturer at Oxford in Ancient Philosophy in 1949. Granted two years of study-leave, Ackrill was a visiting scholar at the Institute for Advanced Study in 1950-51 (as he was again in 1961-62) before becoming, in 1953, a tutorial fellow at Brasenose College. In 1966, Oxford university created a statutory chair in the History of Philosophy, to which Ackrill was elected as the first holder. He retained that Chair, whilst remaining a fellow of Brasenose, until he retired in 1989 as an Emeritus Professor. In 1981 he was elected a Fellow of the British Academy and, in 1996, an Honorary Fellow of St John's.
In 1953 he married Margaret Kerr with whom he had four children.
John Lloyd Ackrill died in Oxford on 30 November 2007.
In 2009, Brasenose College inaugurated The John Ackrill Memorial Lecture which is held annually "in honour of the outstanding contribution he made to the study of ancient philosophy".
^ Owen Goldin "J. L. Ackrill, Essays on Plato and Aristotle." in Bryn Mawr Classical Review 98.4.01.
^ a b Judson, Lindsay (2009-12-17). "John Lloyd Ackrill 1921–2007". doi:10.5871/bacad/9780197264577.001.0001/upso-9780197264577-chapter-1.
^ a b c "Professor John Ackrill: Oxford Professor of the History of Philosophy". The Independent. Retrieved 2018-11-30.
^ Organ, Joe. "John Ackrill Memorial Lecture in Ancient Philosophy 2011 - Brasenose College, Oxford". www.bnc.ox.ac.uk. Retrieved 2018-11-30.
This page was last edited on 11 March 2019, at 05:49 (UTC).


text:
Rockstar to Release Next-Gen Game in 2015
by James Gough
in Articles, Video Games
Earlier this week Take Two, publisher for the Grand Theft Auto and Borderlands series' and other games under the Rockstar and 2K Games labels, announced their Quarter 4 2013 financial reports. The reports provided confirmation that GTA V has now shipped a colossal 33 million copies and reached more than $1 billion in sales as well as impressive sales figures for Borderlands 2 and Bioshock Infinite, shipping 9 million and 6 million units respectively.
Take Two also confirmed its release slate for the current fiscal year which was mostly comprised of announced and expected games, although there was one rather large surprise involved – Rockstar Games, developers of the GTA series, will be releasing an as yet unannounced game on next-gen systems (PS4 and Xbox One) before the fiscal year is over.
Several possibilities have cropped up, including repeated information regarding a GTA V port to the new generation of consoles, although it's hard to image a new version of the game being released while the PS3 and Xbox 360 sales are still performing well.
Other possible options would be a sequel to the highly rated 2010 game Red Dead Redemption – again, rumors have leaked suggesting the game is actively under development with the title Red Dead Rebellion being mentioned more than once. Given that the game will be Rockstar's first release on the new gen consoles, it seems fairly likely they would build upon the current fan base of their Red Dead IP rather than release something new entirely.
GTA V's Agent Easter egg – a hint at their next-gen game?
Never a company to play by the rules though, Rockstar could equally surprise everyone by finally revealing the 70s spy game Agent as the new release. Agent was originally announced way back at e3 in 2009, nearly five years ago and there's been very little of the game mentioned since. However Rockstar are a company who like to tease fans with in-game Easter eggs and their most recent release, GTA V, included a high powered and weaponised car during one main story mission with the cars license plate reading 4G3NT. The financial report does state the mystery next-gen game is unannounced and although information is thing on the ground, Agent has technically been announced.
Whichever game it is that the report refers to, it seems that neither Rockstar or Take Two are ready to comment yet and Rockstar have a history of not attending e3, making a reveal or announcement there highly unlikely. Whatever the next game is, Rockstar will tease fans and let us know when they feel comfortable, until then everything else is simply speculation or calculated guesswork.
We'll have more on the game as details become available to share, but until then let us know in the comments what you think the mystery game will be.
Tags: agentgrand theft autoPS4red deadrockstar gamestake twoxbox oneXbox One


text:
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The Atkinson Graphic
The Crofton Journal
The Niobrara Tribune
The Wakefield Republican
The Plainview News
Basketball: Girls Jr. High
Jan 18 from 4:00 PM to 6:00 PM
Pierce Public Schools, 201 N Sunset St, Pierce, NE 68767, USA
Basketball: Girls Freshmen/Boys Freshmen vs. Wayne
Crofton High School, 89048 NE-121, Crofton, NE 68730, USA
The freshmen girls play at 6:00 p.m. The freshmen boys play at 7:00 p.m.
Crofton Community Club Meeting on Zoom
Basketball: Boys JV/Girls JV/Girls Varsity/Boys Varsity
Wayne, NE 68787, USA
The games will begin at 4:30 p.m., 4:30 p.m., 6:00 p.m., and 8:00 p.m., respectively.
FCCLA District Competition
Wayne State College, 1111 Main St, Wayne, NE 68787, USA
Basketball: Boys Jr. High/Girls Jr. High
Hartington-Newcastle
Basketball: Girls Freshmen/Boys Freshmen vs. Norfolk
The freshmen girls game starts at 6:00 p.m. The freshmen boys game starts at 7:30 p.m.
Wrestling: Boys varsity invitational
Jan 22 from 10:00 AM to 4:00 PM
Madison, NE 68748, USA
Basketball: Girls JV/Boys JV/Girls Varsity/Boys Varsity
The games start at 4:00 p.m., 5:00 p.m., 6:30 p.m., and 8:00 p.m., respectively.
Boone Central Speech Invite
Neligh-Oakdale Public Schools, 600 J St, Neligh, NE 68756, USA
Copyright © Paper & Ink 2021. All rights reserved.


text:
Andrew Humphrey, CBM, Meteorologist And Station Scientist
Published: March 27, 2021, 10:43 AM
Updated: March 27, 2021, 11:26 PM
Tags: andrew, humphrey, andrew humphrey, weather, passover, palm sunday, forecast, weather forecast, detroit weather, detroit forecast, detroit weather forecast
Metro Detroit weather: Milder with sunshine Saturday afternoon, rain showers arrive at night
Highs near 60 degrees
Published: March 27, 2021, 10:43 AM Updated: March 27, 2021, 11:26 PM
Saturday night becomes cloudy with rain showers redeveloping by midnight and afterward. Temperatures remain above freezing overnight. Across the region, lows will be in the low and middle 40s.
DETROIT – Welcome to Saturday afternoon, Motown.
Sunday will be mostly cloudy in the morning and partly sunny in the afternoon. Daytime temperatures will be lower than Saturday; in the low and middle 50s. Jackets will be needed all day to stay warm and comfortable.
Monday will be sunny and chilly to cool. Afternoon temps will be near 55 degrees.
Tuesday will be milder with sunshine. Highs will be near 65 degrees.
Wednesday, the last day of March, will have a chance of rain. It will be cooler and cloudier with highs in the middle 50s.
Marine Forecast
Saturday: Mostly sunny. Wind: E 4 to 9 knots; Waves: 1 to 2 feet; Water Temp: 38 degrees.
Saturday Night: Cloudy, rainy. Wind: SSE 5-10 knots. Waves: 0 to 2 feet. Water Temp: 38 degrees.
Sunday: Morning rain, then mostly cloudy. Wind: SW 9-18 knots; Waves: 1 to 3 feet. Water Temps: 38 degrees.
Lake St. Clair
Lake Huron
Track the live Michigan Weather Radar here
Track severe weather alerts here
Submit storm photos here
Find more weather forecast articles at Weather Center
Remember to download the FREE Local4Casters weather app -- it's easily one of the best in the nation. Just search your app store under WDIV and it's right there available for both iPhones and Androids! Or click the appropriate link below.
Download for iPhone
Copyright 2021 by WDIV ClickOnDetroit - All rights reserved.
Andrew Humphrey, CBM
Andrew Humphrey is an Emmy Award winning meteorologist, and also an AMS Certified Broadcast Meteorologist (CBM). He has a BSE in Meteorology from the University of Michigan and an MS in Meteorology from the Massachusetts Institute of Technology, where he wrote his thesis on "The Behavior of the Total Mass of the Atmosphere."


Set at a summer sleep-away camp, this debut novel explores the complexities of female friendship over time from adolescence through early adulthood. Perennials offers readers a unique look at the bliss and beauty of girlhood, as well as the grief of growing up and remembering when and where you lost your innocence.
Mandy Berman is a writer from Nyack, New York. Perennials is her debut novel. She holds an MFA in fiction from Columbia University. She lives and writes in Brooklyn.


LONG BEACH – It has been called "the largest regatta in North America," and who's to argue? Alamitos Bay and Long Beach yacht clubs will be among 31 clubs from San Diego to Santa Barbara and east to Arizona staging the Southern California Yachting Association's 80th annual Midwinter Regatta today and Sunday.
There will be races for sailboats, radio-controlled models, land yachts, powerboats (predicted log competition) and outrigger canoes – in all, as many as 600 boats in 80 classes.
Alamitos Bay YC will run small boats inside the bay and outside on the ocean. Long Beach YC will line up big boats on an ocean course.
"We are praying for good weather," Midwinter Chairman Peter Glick said.
Over the years since 1928 the Midwinters have been interrupted only by World War II but not by the Great Depression, so a mere recession shouldn't interfere with the fun.
Weather is always a threat, but the forecast this weekend is for light winds and only a slight chance of rain by late Sunday night.
ABYC will have racy 505 and International 14 skiffs, F-18 catamarans, A-Cats, Finns, Lasers, Etchells, Cal 20s and Lido 14 dinghies.
LBYC will run Catalina 37s, Express 37s, Santana 30/30s, J/29s, Shock 35s and two PHRF handicap classes of ocean racers rated faster than minus-3 seconds per mile and 0-120.
In the same inshore local, Seal Beach YC will host Cal 25s, Catalina 25s, 27s and 30s and a PHRF fleet of boats rating 123 and up.
Multiple races are scheduled each day starting at noon, conditions permitting.


Heating elements from Every Appliance Part for use on your water heaters with competitive shipping and low prices. We have manufacturers of these parts, such as, Goodman and American Water Heater Co.
This aluminum/zinc anode rod can be used on some water heater models.
This part can be used on some American Water Heater Company brand Water Heaters.
This Natural Gas Burner Assembly is compatible with certain Water Heater models.
This part is a flame sensor and igniter assembly for hot water heaters.
This part can be used on some Maytag brand Water Heaters. This part is a 4500-Watt, 240-Volt screw-in type water heater element. This replacement element must be the same voltage and wattage as the element being replaced.


text:
Tag: anthony rapp
Gossip Girl Alert: Leighton Meester Hearts DVF, Blake Lively Hearts…RENT?
So I didn't wake up today and say to myself, "Dude, you should totally be a paparazzi specializing in CW stars," but it seems as though I ended up being one today… I just happen to spot almost all the major players in the cast of Gossip Girl! I was walking around the tent for Diane von Furstenberg at Bryant Park today and all of a sudden out the corner of my eye I saw a girl wearing yellow, and then a herd of people instantly swarming around her and her friend.
Walking closer, I recognized Miss Leighton Meester! I snapped a few photos, and then only later did I realize that the other girl accompanying her was none other than Jessica Szohr!
Continue reading "Gossip Girl Alert: Leighton Meester Hearts DVF, Blake Lively Hearts…RENT?"
RENT on Good Morning America
This morning I got up at the buttcrack of dawn in order to get to Bryant Park by 6am. "Why?" you may ask? Because the current cast of RENT, alongside original cast members Adam Pascal and Anthony Rapp, were performing as part of the Good Morning America (GMA) Summer Concert series, and I had good enough fortune to get a VIP entrance with a fellow "RENThead" friend who worked at ABC.
Yes, yes, as you are probably already aware, I'm a long-time RENT fan, so although it was not *fun* trying to catch the subway when it was nearly pitch black out, I did it anyway (for the sake of the LOLz).
After 7am there were a few sound checks–first with Adam and Anthony (practicing "What You Own"), then with the full current cast, which just happens to feature two additional original cast members: "Seasons of Love" soloist Gwen Stewart and former ensemble member Rodney Hicks (now playing Benny). Tracie Thoms, who played the role of Joanne in the 2005 movie remake of the musical has also joined the production for it's final months. (RENT will close September 7, 2008, making it the seventh longest running show in Broadway history.)
During sound check, one of the current members of the Bway cast handed Anthony their camcorder and Anthony went gonzo filming them as they rehearsed "Seasons"–to the point where he was directly in the audience's sightlines, up in all the performer's faces. I guess once a "Mark" always a "Mark."
Continue reading "RENT on Good Morning America"
Posted on January 20, 2002 August 8, 2015
Anthony Rapp Gets a Nod on the Golden Globes — Waaahh?
MTV is so lame sometimes. Like their new Handpicked album. Coldplay "Yellow," Travis "Sing"… Five for Fighting, Yorn, Adams. Oyyyyyy… But we like the picture they put up on their website of good ol' CP.
Which brings us to something more enjoyable. MTV2 premiere Thursday– KYLIE MINOGUE. Gentlemen, start your engines.
I missed Ewan on the Golden Globes. Ooops. And Russell Crowe just THANKED Anthony Rapp in his speech. First Adam on the Mandy Moore diary… now Anthony. Ok. Whatever. Apparently Anthony is doing some stuff with the Japanese cast of Rent… Yeah… I don't get it either.. Go to his site to figure it out.


text:
Different basal levels of CaMKII phosphorylated at Thr at nociceptive and low-threshold primary afferent synapses.
Larsson, Max LU and Broman, Jonas LU (2005) In European Journal of Neuroscience 21(9). p.2445-2458
Postsynaptic autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) at Thr286/287 is crucial for the induction of long-term potentiation at many glutamatergic synapses, and has also been implicated in the persistence of synaptic potentiation. However, the availability of CaMKII phosphorylated at Thr286/287 at individual glutamatergic synapses in vivo is unclear. We used post-embedding immunogold labelling to quantitatively analyse the ultrastructural localization of CaMKII phosphorylated at Thr286/287 (pCaMKII) at synapses formed by presumed nociceptive and low-threshold mechanosensitive primary afferent nerve endings in laminae I-IV of rat spinal cord. Immunogold labelling was enriched in the postsynaptic densities of... (More)
Postsynaptic autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) at Thr286/287 is crucial for the induction of long-term potentiation at many glutamatergic synapses, and has also been implicated in the persistence of synaptic potentiation. However, the availability of CaMKII phosphorylated at Thr286/287 at individual glutamatergic synapses in vivo is unclear. We used post-embedding immunogold labelling to quantitatively analyse the ultrastructural localization of CaMKII phosphorylated at Thr286/287 (pCaMKII) at synapses formed by presumed nociceptive and low-threshold mechanosensitive primary afferent nerve endings in laminae I-IV of rat spinal cord. Immunogold labelling was enriched in the postsynaptic densities of such synapses, consistent with observations in pre-embedding immunoperoxidase-stained dorsal horn. Presynaptic axoplasm also exhibited sparse immunogold labelling, in peptidergic terminals partly associated with dense core vesicles. Analysis of single or serial pCaMKII-immunolabelled sections indicated that the large majority of synapses formed either by presumed peptidergic or non-peptidergic nociceptive primary afferent terminals in laminae I-II of the spinal cord, or by presumed low-threshold mechanosensitive primary afferent terminals in laminae IIi-IV, contained pCaMKII in their postsynaptic density. However, the postsynaptic levels of pCaMKII immunolabelling at low-threshold primary afferent synapses were only approximately 50% of those at nociceptive synapses. These results suggest that constitutively autophosphorylated CaMKII in the postsynaptic density is a common characteristic of glutamatergic synapses, thus potentially contributing to maintenance of synaptic efficacy. Furthermore, pCaMKII appears to be differentially regulated between high- and low-threshold primary afferent synapses, possibly reflecting different susceptibility to synaptic plasticity between these afferent pathways. (Less)
LarssonBlackwell.pdf
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Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/140351
Larsson, Max LU and Broman, Jonas LU
Neurophysiology (research group)
European Journal of Neuroscience
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ebd4a430-5ca4-4856-a882-d2a48c00bf3e (old id 140351)
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date added to LUP
@article{ebd4a430-5ca4-4856-a882-d2a48c00bf3e,
abstract     = {Postsynaptic autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) at Thr286/287 is crucial for the induction of long-term potentiation at many glutamatergic synapses, and has also been implicated in the persistence of synaptic potentiation. However, the availability of CaMKII phosphorylated at Thr286/287 at individual glutamatergic synapses in vivo is unclear. We used post-embedding immunogold labelling to quantitatively analyse the ultrastructural localization of CaMKII phosphorylated at Thr286/287 (pCaMKII) at synapses formed by presumed nociceptive and low-threshold mechanosensitive primary afferent nerve endings in laminae I-IV of rat spinal cord. Immunogold labelling was enriched in the postsynaptic densities of such synapses, consistent with observations in pre-embedding immunoperoxidase-stained dorsal horn. Presynaptic axoplasm also exhibited sparse immunogold labelling, in peptidergic terminals partly associated with dense core vesicles. Analysis of single or serial pCaMKII-immunolabelled sections indicated that the large majority of synapses formed either by presumed peptidergic or non-peptidergic nociceptive primary afferent terminals in laminae I-II of the spinal cord, or by presumed low-threshold mechanosensitive primary afferent terminals in laminae IIi-IV, contained pCaMKII in their postsynaptic density. However, the postsynaptic levels of pCaMKII immunolabelling at low-threshold primary afferent synapses were only approximately 50% of those at nociceptive synapses. These results suggest that constitutively autophosphorylated CaMKII in the postsynaptic density is a common characteristic of glutamatergic synapses, thus potentially contributing to maintenance of synaptic efficacy. Furthermore, pCaMKII appears to be differentially regulated between high- and low-threshold primary afferent synapses, possibly reflecting different susceptibility to synaptic plasticity between these afferent pathways.},
author       = {Larsson, Max and Broman, Jonas},
issn         = {1460-9568},
language     = {eng},
number       = {9},
pages        = {2445--2458},
publisher    = {Wiley-Blackwell},
series       = {European Journal of Neuroscience},
title        = {Different basal levels of CaMKII phosphorylated at Thr at nociceptive and low-threshold primary afferent synapses.},
url          = {https://lup.lub.lu.se/search/ws/files/2926404/624764.pdf},
doi          = {10.1111/j.1460-9568.2005.04081.x},
volume       = {21},


Just like The Baby Niche's style we've created our own take on a classic wooden toy.
FIVE Canadian Walnut + Canadian Maple shapes to stack.
Measuring 4" tall. A great size for little fingers to hold + practice their shapes.
Available untreated or treated with organic coconut oil.


Choir of St. Luke in the Fields, under the direction of David Shuler, presents The Splendor of the Spanish Renaissance on Thursday, February 28, 2019 at 8 p.m. at the Church of Saint Luke in the Fields, 487 Hudson Street. There will be a lecture by Dr. Raymond Erickson at 7 p.m.
The Choir of St. Luke in the Fields is the resident vocal ensemble at the Church of St. Luke in the Fields in New York City's historic Greenwich Village. Under the direction of David Shuler since 1988, the Choir regularly performs masses and motets dating from the fifteenth century to the present as part of the church's liturgy. They are known for their historically informed performances of Early Music. The Choir presented the North American premieres of Georg Phillip Telemann's St. Matthew Passion (1746) in 2003 and St. Luke Passion (1748) in 2013. In 2011, the ensemble gave the first New York City performance of C.P.E. Bach's St. Matthew Passion (1769). The 2015 season featured a rare performance of Handel's Esther – his first English oratorio. Their most recent recording, Music of Pierre de Manchicourt: Missa Reges Terrae and other works, was released to critical acclaim on the MSR label in September 2016. In November 2018, they released a recording of Palestrina's Missa Tu es Petrus and motets, also on the MSR label.


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The Flash S7E01 – "All's Wells That Ends Wells"
The Flash left us in a precarious place last season, and it starts back up by leaving us in tears.
Spoilers below
The title of the season seven premiere, "All's Wells That Ends Wells," should have told us that this wasn't going to end well at all.
Nash Wells sacrifices himself for Barry. (Katie Yu/The CW)
We've always had a Wells. Now that Nash Wells (Tom Cavanagh) has sacrificed himself and all the other Wells, does that mean we won't get another? As Barry Allen (Grant Gustin) said, there is no Team Flash without a Wells.
The Flash has been going through some changes. Last season marked the first time the show had two different villains, one in the first half of the season and one in the second half. While it may have seemed like it was written that way because of the Arrowverse crossovers, it was an intentional shift.
Chester helps get Barry's speed back. (Katie Yu/The CW)
We've also seen more additions to Team Flash. Chester (Brandon McKnight) and Allegra (Kayla Compton) can feel truly part of the team now. Not only did they help save Barry and bring back his speed, but they were also part of an experiment gone wrong. How many times has a theory gone wrong in the past?
This time particles got transferred into Barry, and all the Wells spoke through him. And with Barry's speed dwindling, it could have killed him if the particles were in him too long. Between all the Wells, Chester, and Allegra, they got the particles back into Nash.
Allegra is sad she will never get to know Nash. (Katie Yu/The CW)
It was a nice farewell to all the Wells from the last six seasons, even if none of us were ready to say goodbye to them. We got one last glimpse at their personalities. The Flash is never going to be the same again.
On a happier note, Barry is now able to save Iris (Candice Patton). How exactly he and Team Flash will rescue her is still a mystery, but now that he's got his speed back, they'll definitely find a way.
I hope this means the original Team Flash will be back at it. It's just not the same without Cisco (Carlos Valdes) and Caitlin (Danielle Panabaker).
Iris is doing her part from where she is. She's still fighting to break through and believing that Barry and Team Flash will also find a way.
How sad were you to say goodbye to all Wells's characters? Tweet @Fandomopolis or comment below.
Categories:	Movies & TV, Reviews	/ No Responses / by Mandy Carr
Post Author: Mandy Carr


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DUMBARTON OAKS STUDIES
Dumbarton Oaks Studies 33
Sowing the Dragon's Teeth
Byzantine Warfare in the Tenth Century
Eric McGeer
$29.95 • £23.95 • €27.00
x Text
Dumbarton Oaks Research Library and Collection > Dumbarton Oaks Studies
HISTORY: Middle East: General
HISTORY: Military: Wars & Conflicts (Other)
HISTORY: Europe: Medieval
See all: Dumbarton Oaks Studies
The military achievements of the emperors Nikephoros Phokas, John Tzimiskes, and Basil II brought the Byzantine Empire to the height of its power by the early eleventh century. This volume presents new editions and translations of two military treatises—the Praecepta militaria of Nikephoros Phokas and the revised version included in the Taktika of Nikephoros Ouranos—outlining the tactical system used by Byzantine armies in campaigns against Muslim forces in Cilicia and Syria. Products of experienced soldiers, the texts offer a realistic view of Byzantine warfare and reveal the sophistication of Byzantine military science. Eric McGeer places the treatises in military historical context; explores the factors that led the Byzantine army to fight as it did; and investigates morale, discipline, and leadership—all of which determined the difference between failure and success.
The Dumbarton Oaks Medieval Library


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From the brink of the Worldwound, where demonic hordes lay siege to the mortal realm, to the battlefields of Mendev and Nirmathas, where soldiers distinguish themselves as heroes of ideals, battle is a common part of life in the Inner Sea region. Whether practiced by virtuous crusaders, fierce gladiators, or daring scoundrels, skill with a blade and knowledge of when to use it can mean the difference between life and death. The secrets of battle might not be etched on altars or scribed in spellbooks, but they're just as diverse and powerful as any magic—and just as available for bold heroes to claim!
A who's who of the Inner Sea region's deadliest martial masters.
Details on four types of martial training grounds—dojos, gladiatorial arenas, thieves' guilds, and war colleges—along with rules for joining and honing one's skills within such organizations.
Rules for several types of specialized or variant combat, including the secrets of the legendary Aldori swordlords, fighting styles particular to Golarion's many faiths, gladiatorial combat, mastering monstrous mounts, and using technology in combat.
Two new cavalier orders—the order of the beast and the order of the guard—along with new context for each knightly order.
More than a dozen new archetypes for all manner of brave battlers, including the gun scavenger, the monk of the seven forms, the Shoanti burn rider, and the Tanglebriar demonslayer.
Two new prestige classes—the Pure Legion enforcer and the Ulfen Guard.
Dozens of new magic items guaranteed to protect combatants through the most brutal battles and transform even novices into masters of war.
Inner Sea Combat is intended for use with the Pathfinder Roleplaying Game and the Pathfinder campaign setting but can easily be used in any fantasy game.
Written by Dennis Baker, Jesse Benner, John Compton, and Thurston Hillman.
Cover Art by Yu Cheng Hong.
The Aldori feats are bad. Tying ranger combat styles with a deity is a bad idea. Combat performance is big NO. The House of perfection's feats are bad. Oath against chaos is good, oath against grotesquery is ok. The monstrous feat chain is so-so. There are a couple of interesting Rogue's Skill taunt, but the others are quite bad. Firearm feats are ok.
The Combat school section is somewhat interesting, but not great. I guess that It has a greater appeal to people who are accustomed to the Fame rewards mechanics.
Cavalier orders are meh at best. Prestige classes are ok. Archetypes are a mixed bag, with a few couple of good ones, but the rest are quite bad.
Basics- MORTAL COMBAT! Inner Sea Combat focuses on marital characters and how to build these characters and their world into your Pathfinder Game. The book starts by discussing nations and their interactions with martial characters. Next, the book adds feats and a discussion on how specialized martial characters function within the rules of Pathfinder. After specialization, the book moves to schools/guilds and rules to operate these in Pathfinder. From schools, the books present new prestige classes and archetypes for classes from barbarian to the rogue. The last section of the book focuses on magic items that specialized characters from this book might need.
One of the things I like best about a book like Inner Sea Combat is that it's much easier to see immediate uses for the new options contained within. Pathfinder is a game with a lot of options—far more than most people can easily keep track of. While generic books like Ultimate Combat may contain many interesting abilities, they can quickly get lost in the deluge as they don't have a context to make them stand out. But with the world-specific flavour that Inner Sea Combat offers, its options are instantly more recognizable. They make both the characters and the world more interesting. There are several things in here that I already want to introduce to my own games, and any game book that fills me with ideas is a good book, in my opinion.
Hoo yes, Inner Sea Magic is gonna have a little sister!
As someone who prefers to play martial characters, I'm very much looking forward to this book.
Finally....been waiting for this book for a long time...hopefuly it does not make fighters cool by replacing them weizard wannabes like a certain other company's book...and to stealth playtest their next edition.
And just what is wrong with "common brawling" may I ask? Best way to unwind after a hard day's aventuring with worship of Cayden Cailean and a good brawl.
Perhaps there'll be a dedicated tavern-brawl-fighting-style?
I hope the Shoanti War Paint from A History of Ashes gets an update.
This looks like it is going to be a great product!
Will this book have a list of Notable Martial characters in the Inner Sea like Inner Sea Magic had for spellcasters?
I hope so, that would be interesting.
I hope it has rules for Military Academies, much like how ISM had Magic Academies.
Lord Gyr of House Gixx. Notable level 13th rogue and veiled master-in-disguise.
Ever seen Lord Gyr and a veiled master in the same room together? I haven't either.
Ever seen Lord Gyr and a veiled master in the same room together?
Yeah, but he was the only one there, wink wink nudge nudge.
Please let there be a low-level "hadoken" ki-power for monks.
I would really like some stuff like that for monks.
I wonder how much Jalmeray info might be in this, given there's still no psychic magic supplement on the horizon.
Will certain 3.5 prestige classes be updated to Pathfinder in this book? I'm thinking of the Chevalier (Second Darkness 2), the Justiciar (Curse of the Crimson Throne 2), the Liberator (Second Darkness Player's Guide), the Lion Blade (Taldor Companion), and the Living Monolith (Osirion Companion).
And I'm hoping that those other 3.5 prestige classes which still remain in limbo will eventually get their Pathfinder updates. Maybe Inner Sea Gods will deal with the Balanced Scale of Abadar (Dark Markets/Katapesh), the Pain Taster (Second Darkness 3), the Spherewalker (Rise of the Runelords 2), and possibly the Brightness Seeker (Elves of Golarion), and the two upcoming Osirion/northern Garund sourcebooks will present the updated Genie Binder (Legacy of Fire 4).
And where would one put the original Shackles Pirate (3.5 Campaign Setting, now replaced by the Inner Sea Pirate)? I always thought that those fog ships were a nifty ability.
While I'm hoping this is mostly information for individual characters, if we get a little bit for mass combat/that whole new 'troop' idea specifically for Golarion, I will be a very happy customer.
Swashbuckler alternate-class designed by James Jacobs!
I'm not so sure that Paizo is too keen on releasing new classes in the non-Core line... But it'd be interesting.
The best comparison for this book is Inner Sea Magic. So, don't expect new base classes, but you CAN expect some academy type stuff, lists of famous NPCs, lots of archetypes and some prestige classes and some new rules and expansions to existing subsystems for combat stuff (or perhaps some new stuff even). There's not gonna be a spell chapter, of course, but there will be a chapter of magic items and stuff that work great for martial characters.
Expectations management question: Could we see some new rules to support characters outside the usual magic item expectations? Like gearless ascetic monks or warriors who keep their one special weapon throughout their career?
I've done the latter by allowing a Masterwork weapon at level one for a trait. Basically Heirloom weapon without the other bonuses. Not unbalancing and the player had the weapon all the way to level 14, when the game collapsed.
Is this placeholder art from the Alkenstar adventure that's not yet been released?
It's from Champions of Purity.
I'm relatively sure my opinion on the need for a swashbuckler base class is well established.


text:
Ariel Winter Workman (Fairfax, Virginia; 28 de enero de 1998), conocida como Ariel Winter, es una actriz, actriz de voz, y cantante estadounidense. Es más conocida por su papel como Alex Dunphy en la serie de televisión Modern Family, por el cual ganó el Premio del Sindicato de Actores al mejor reparto de televisión en una comedia, junto con el resto de sus compañeros de elenco.

Vida personal
Ariel Winter es hermana de la actriz Shanelle Gray y del actor Jimmy Workman. El 3 de octubre de 2012, Winter se fue a vivir con su hermana mayor después de denunciar a su madre por abusar física y emocionalmente de ella. Su madre niega las acusaciones. Shanelle Workman solicitó entonces la tutela permanente y el control financiero de Winter.

En junio de 2015, a los 17 años, Ariel Winter acudió a que le realizaran cirugía para la reducción del busto.

Filmografía

Cine

Televisión

Videojuegos

Premios y nominaciones

Referencias

Enlaces externos

Actrices de San Diego
Actrices de cine de Estados Unidos
Actrices de televisión de Estados Unidos
Actrices de voz de Estados Unidos
Actrices infantiles de Estados Unidos
Nacidos en Virginia

redpajama_set_name: RedPajamaWikipedia


Two years ago I spend a week during summer holiday on a small island in Danmark. Hand mixer broke, daughter really wanting desert. Improvised solution. Powerful.
Wonder what a blender of this kind will look like. Any?


Australia has gone into reverse on energy efficiency and now ranks behind India, Indonesia and China in what is a huge, largely untapped opportunity to cut energy bills and carbon emissions.
In a 2018 international ranking on energy efficiency, released overnight, Australia ranks 18th among the world's 25 largest energy users, down from 16th in 2016 and at the bottom of the list of major developed economies.
Italy and Germany tied for top place, scoring almost double Australia's points, while Saudi Arabia was last.
Without stronger measures to improve, it will be "impossible" for Australia to meet the carbon reduction goals necessary to cap global temperature increase to 2 degrees Celsius, said report author Shruti Vaidyanathan at the American Council for an Energy-Efficient Economy.
It will also be more expensive, said Australian Energy Efficiency council chief Luke Menzel, pointing to CSIRO research last year that found ambitious improvements in energy productivity would cut household energy bills and reduce wholesale power prices.
"We are a way behind our international competitors in terms of the energy efficiency and productivity of our economy but that means there are a lot of fairly straightforward options and opportunities that we have to bring down energy bills pretty quickly by pursuing those demand-side savings," Mr Menzel said.
"It's a bit of a wake-up call and hopefully a timely reminder that the NEG [National Energy Guarantee] is not the only game in town. There's a whole other conversation we need to have about what's happening behind the meter."
The strongest score for Australia was in building energy efficiency, the only area where it outperformed the median thanks to building codes, its commercial building labelling program and appliance labelling.
But in industrial and transport energy efficiency, Australia ranks near the bottom. In industrial energy efficiency it was particularly poor, putting it 22nd out of 25, with the report highlighting the absence of accords with the manufacturing sector on efficiency or requirements for regular energy audits at sites.
In transportation Australia also lags behind, being the only developed economy without fuel economy standards for passenger vehicles and a low use of public transit. Australia invests only about 26¢ in rail transport for every dollar on road construction, it noted.
Australia has a national energy productivity plan which aims to lift productivity by 40 per cent between 2015 and 2030, but implementation of the goals are seen as "slow".
"Our global competitors are saving energy and money with smart energy-efficiency policy and investments, while Australia lags at the back of the pack," Mr Menzel said.


Appeal from the Circuit Court for Lee County, John W. Dommerich, J.
James Marion Moorman, Public Defender, and Diane Buerger, Asst. Public Defender, Bartow, for appellant.
Robert A. Butterworth, Atty. Gen., Tallahassee, and Dale E. Tarpley, Asst. Atty. Gen., Tampa, for appellee.
R.G., a juvenile, appeals an adjudication of delinquency and commitment for grand theft. He challenges the denial of his motion to dismiss the delinquency petition. Because the delinquency petition was not filed within forty-five days of custody and no extension of time was granted, we reverse.
Section 39.048(6), Florida Statutes (1991), states: "On motions by or in behalf of a child, a petition alleging delinquency shall be dismissed with prejudice if it is not filed within 45 days after the date the child is taken into custody. The court may grant an extension of time not exceeding an additional 15 days for cause, upon motion by the state attorney."
Any motion to suppress, sever, or dismiss shall be made prior to the date of the adjudicatory hearing unless an opportunity to make such motion previously did not exist or the party making the motion was not aware of the grounds for the motion.
A juvenile can knowingly and voluntarily waive his right to have a delinquency petition filed against him within the statutory period. R.F.R. v. State, 558 So.2d 1084 (Fla. 1st DCA 1990). There was, however, no knowing or voluntary waiver in this case. Section 39.048(6), Florida Statutes (1991), grants a juvenile a substantive right, and substantive statutes supersede procedural rules. See S.R. v. State, 346 So.2d 1018 (Fla. 1977); see also D.C.W. v. State, 445 So.2d 333 (Fla. 1984). Therefore, dismissal of the delinquency petition was mandatory in this case if the petition was filed after the expiration of the statutory period. 346 So.2d at 1019.
In Y.S. v. State, 620 So.2d 245 (Fla. 3d DCA 1993), the Third District held that section 39.048(6), Florida Statutes (1991), precluded the refiling of a delinquency petition where the charge had been nolle prossed more than forty-five days after the child was taken into custody. As in Y.S., the original petition in this case was nolle prossed. Thus, the subsequent petition began a new prosecution even if for the same offense. Cf. State v. Vazquez, 450 So.2d 203, 204 (Fla. 1984) (nolle prosequi amounts to nullification of information and renders nugatory any proceedings carried on subsequently under same information).
We find distinguishable those cases which have held that the filing of the original petition within forty-five days of custody tolls the limitation period. See, e.g., Rubin v. State, 390 So.2d 322 (Fla. 1980); L.G.R. v. State, 485 So.2d 13 (Fla. 3d DCA 1986); State v. Garofalo, 453 So.2d 905 (Fla. 4th DCA 1984). In those cases, the state did not enter notices of nolle prosequi. Instead, the charging documents were refiled or amended to correct inaccuracies. Thus the subsequent documents were sufficiently linked to the original charging documents so as to constitute continuations of the original prosecutions.
We therefore reverse the adjudication and commitment for grand theft and remand with directions that R.G. be discharged. We need not discuss R.G.'s remaining point on appeal.
DANAHY, A.C.J., and LAZZARA, J., concur.