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Home /News /Proposed Wellness Centre in Coby
Proposed Wellness Centre in Coby
Wellness Centre Update
We are one more step closer to building a Wellness Centre to serve the needs of people in the northern areas of Kawartha Lakes!
On June 9, 2020, the Chamber presented the Feasibility Study for the Wellness Centre in Coboconk to City Council and we wanted to give you a quick update on the result of that presentation.
The City funded Feasibility Study was received by Council with thanks to the Chamber for preparing it. Council referred the Study to staff for their review and input during the third quarter, so it can be included in the budget process for 2021.
With the Feasibility Study now completed, we can turn our attention to securing the provincial and federal grant funding we are seeking. We can also begin to raise funds locally! The Wellness Centre project is going to have a long term impact on our community - not just for our health and well-being, but also with construction jobs, good-paying year-round jobs once it is built, and a positive impact on our local businesses too!
We will be bringing you some news this summer about ways to get involved in supporting the new Wellness Centre, but in the meantime, if you have ideas or you would like to organize a fundraiser to benefit the Wellness Centre, please get in touch with us. We have already heard from a few groups who are ready to pitch in to help get this Wellness Centre built, but it is going to take a lot of effort and you know the saying: Many hands make light work! Let's work together to make this project a reality!
Finally, we would like to say a big thank you to the community - we had more than 150 people attend the Community Meetings for the Wellness Centre, more than 450 responded to the Community Health Needs Survey letting us know your needs and wants, businesses and our local doctor who have shown their enthusiasm for the project, and a wonderful core team of volunteers who have spent countless hours getting this project to this point.
We look forward to hearing your thoughts and ideas about how to make this project a reality!
Want to read the feasbility report? Click here!
Want more info, including the Community Health Needs Assessment? Read our appendices here!
What is this project?
The concept is to renovate and expand the Coboconk Train Station building, preserving that significant piece of Coboconk history, and building space for 2-3 doctors, walk-in clinic hours, a dentist, and other complementary practitioners such as seniors foot care, massage, physio and chiropractic care. Expanded space through new construction, new parking, and better road access are all part of the new plans.
Why Does Coboconk Need a Wellness Centre?
There has been a long-time perception of the community that there are not enough health services in the northern area of Kawartha Lakes. Although the community of Coboconk is very grateful to have a long-time family doctor, there are many who are still without a family doctor both in Coboconk and in its surrounding communities. No after-hours care exists in the north, and the need for this has been heard clearly. The nearest hospitals are 30-60 minutes away, and their emergency departments report high levels of patients utilising emergency department services for non-emergencies.
Given the fact that the original Coboconk Medical Centre building was shut down 4 years ago due to a compromised foundation and the family doctor was moved into a temporary portable building until a solution was found, it is clear that a more permanent solution is needed for health services in the north.
What has the CNACC Been Doing to Make this Happen?
The Coboconk, Norland & Area Chamber of Commerce (CNACC) spear-headed an initiative to find the best possible solution for both the community and the municipality. After a deputation to City Council in September of 2018 presenting the issue, Council requested that the Chamber conduct a feasibility report and provided City funds for this purpose. A Feasibility Report has recently been completed and is the result of 18 months of community consultation, primary data collection, research on the gaps in care according to the MOHLTC, site evaluations, and building concept design.
Objectives of the Feasibility Report
To determine:
• Health service gaps of our community;
• If, and/or how a wellness centre offering primary care and allied professional care could address service gaps and increase the efficiency of the current system;
• A model for a wellness centre based on perceived gaps and provincial trends in care;
• Potential services and the level of interest of doctors and allied health professionals in participating in the wellness centre health services delivery model and;
• The feasibility of a wellness centre, including the physical design of the facility, construction costs and the operating costs.
Vision of the Wellness Centre
To provide quality medical and wellness services to the residents and visitors of the City of Kawartha Lakes, Ward One by establishing a permanent wellness centre in the historic Coboconk Train Station. The Wellness Centre will provide a hub for community health that will bring increased access to conventional medicine and allied health care services, as well as community organizations in an underserved geographic area.
By providing space for more primary care physicians and nurse practitioners, much needed after-hours care, mental health supports, blood lab, dental services, home and community care services, pre & post-operative care, chiropractic and physiotherapy services, the needs of people in this area will be better served and will help to alleviate the strain on current health care services offered in Lindsay and Minden. The number of people in this area without a local family doctor is significantly higher than the provincial average, and these residents must drive a minimum of 30 minutes to the nearest hospital and/or after-hours care clinic.
1. There is a Gap In Care - There is a gap in health care services in the northern area of Kawartha Lakes. The family doctor in Coboconk is doing all he can to help the people, but does not have the capacity to address the gap in care. With no rural transit available, a larger than provincial average population of seniors, and a larger than provincial average of people earning a lower income, a local health services centre is greatly needed.
2. Impact on Emergency Departments - Given that the local family doctor is over-capacity, and that there are no after-care services available in the area, the nearest emergency departments are being accessed for non-emergency health care services. By adding to the burden of the nearest emergency departments for non-emergencies, resources at those emergency departments are being diverted from their needed focus on emergencies – an issue always, but even more so in light of the current COVID-19 pandemic and the forecast for future similar situations.
3. Recommended Site - The City-owned historic Coboconk Train Station building and surrounding property is a community facility but currently under-utilised. This site provides the opportunity to renovate the historic building, and expand its footprint with new construction to continue its community meeting use, while also housing a hub for health care and wellness services for those in the northern area of Kawartha Lakes. It has a high walk-ability score, and will bring people into the Coboconk community for their health care services.
4. Key Partnerships Indicate Success - Key partnerships with the community, the municipality, and the Kawartha Lakes Health Care Initiative (KLHCI) – who is mandated with the retention and recruitment of family doctors in Kawartha Lakes – are strengths indicating a high rate of success that this project will reach its goal of providing quality, year-round health care and wellness services to the northern communities.
5. Opportunity for Seniors Housing - The community has been very clear that there is a great need for seniors housing. The size and configuration of the Train Station site provides the opportunity for private developers/investors to build seniors housing, along with respite and hospice services. There are currently 2 developers who have indicated interest in the site for these purposes. People are excited about this possibility!
6. High Economic Benefit - The Wellness Centre will generate significant economic benefits for the community and also the municipality as a whole. Not only will the Wellness Centre create jobs during renovation and construction, there will be a maintained positive economic impact as new doctors and other practitioners, support staff, and community organizations are engaged, and new residents and families find it an attractive place to settle with good access to medical care. Apart from the positive impact on the people of our communities, the documented economic impact of having a doctor in a community is significant. The Kawartha Lakes Health Care Initiative estimates approximately $500,000 - $1,000,000 in economic development/year/physician in a community.
Overall, the Wellness Centre will result in:
• good quality, year-round jobs;
• retention of seniors in our community;
• attraction of new retirees as well as families and professionals;
• attraction of new investment and;
• long term positive impact on local businesses.
7. A Spark for Economic Recovery amid COVID-19 - Given the economic impacts of the COVID-19 pandemic, the Wellness Centre project represents a key opportunity to spark economic activity and prosperity in Kawartha Lakes – both short term construction jobs, and long term good quality, year-round jobs.
Overall, there are many benefits that will emerge through the construction of a Wellness Centre in Coboconk. Most significant are these:
 An innovative, well-designed facility that will attract doctors and practitioners to serve the needs of permanent and seasonal residents in the northern area of the Kawartha Lakes – a Ministry of Health designated under-served area.
 The Wellness Centre will be part of a long-term strategy post-COVID-19 to ensure that the strain of dealing with non-emergencies in our local Emergency Departments is alleviated, allowing Emergency Departments to focus on the pandemic or emergency.
 The Wellness Centre will serve as a lever to significant economic development in the area, benefiting local business, residents, tourists, and the municipality.
Want to get involved in a project that will help to serve the needs of the northern parts of Kawartha Lakes and bring more jobs and economic activity to our area? Email jwilson@coboconknorland.ca or call 705-454-1110. We would love to hear from you!
Want more info? Here are a few resources we can share with you so far:
Slide Presentation: July 2019 Community Meetings
Background Document: The Need for a Wellness Centre in Coboconk
Want to know more about the history of the Train Station and the village of Coboconk? http://cobytrainstation.ca/
More Info to Come...stay tuned!
Coboconk, Norland & Area Chamber of Commerce
6666 Hwy 35 P.O. Box 177,
Coboconk, ON K0M 1K0
chamber@coboconknorland.ca
Copyright © Coboconk, Norland & Area Chamber of Commerce 2020. All rights Reserved.


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The LeftBacks
A Sports Blog For Professional Sports Fans.
Top Memories of SA Sport in my Twenties
Written by Juan on June 24th, 2015 June 24th, 2015 .	Leave a comment
My twenties have come and gone and the big 3-0 is mere hours away. It's been quite a journey and I'm really looking forward to life's next chapter.
But before I look forward, now is as good a time as any for reflection.
The last 10 years has played host to many, many memorable sporting moments and while some of them have been memorable for all the right reasons – others have scarred me for life.
Since this is a celebration, I thought I'd keep it positive. Stick around as I rewind the clock and bring you the top sporting moments of my fleeting twenties.
In chronological order:
I'll go on the record and say that while I always participated actively in the festivity of ODI cricket, I didn't really follow it too closely. But I'll never forget this game as long as I live.
I woke up at a mate's house after one too many Wellington brandies and caught their innings on his couch. It was a massacre and the chief destroyer was everyone's all time favourite Australian – Ricky Ponting. I left for home and forgot it was on.
Imagine my surprise when a couple of hours later I flicked on the telly and we were still in it with Gibbs smashing the ball to all corners.
When we won it was the first time I remember my whole family screaming about a cricket match. #CherishedMemory
Rugby World Cup Final 2007
If I had to rank these on merit, this would be my number one sporting memory from my twenties.
I remember a few days before the World Cup semis – when we were up against the almighty Argentineans (there was still much debate in the media on whether it was Argentines or Argentineans). At some point I realised that we were probably going to be in the final for the second time, and if things were on our side – we could go all the way.
Then England emerged as the victors in the other semi and I knew that, after hammering them 33 – 0 in the group stages, we had this.
In the lead up to the game, my and friends and I stood shoulder to shoulder and sang along to what can only be described as the most eyeball misting rendition of Nkosi Sikelel' iAfrika I've ever seen (find it here). And then when we won, we hit our local bar and the entire establishment was bathed in green and gold.
The following week I had Queen's We Are the Champions on constant repeat. I'll never forget it.
Have you checked that anthem? Do yourself a favour – do it NOW!
London Paralympics
I think the Paralympics was so memorable to me because the Olympics was such a disappointment, particularly from a South African point of view.
During the 2008 Summer games we only managed to take home 1 medal, coming in at 70th place. Conversely, our Paralympians came in 6th place with a massive haul of 30 medals – 21 of those were gold.
It was unreal. We were dominating everything we tried and it made me so immensely proud to be South African.
Two names that stick out for me during that tournament are Natalie Du Toit and pre-drama Oscar Pistorius. I remember getting out of a warm bed at some crazy hour to watch Oscar race the finals.
Soccer World Cup 2010
Even more so than cricket, soccer is a sport that was foreign in my house growing up. But when we won the Soccer World Cup bid and it finally arrived, I found myself totally wrapped up in the euphoria and got behind our boys.
While the tournament didn't go our way – I'll never forget Tshabalala's first goal against Mexico. I'm pretty sure our nation's cheer registered on the Richter Scale that day.
Ever since then I thoroughly enjoy World Cup soccer – even participating in a work Superbru pool in 2014.
Currie Cup final
My latest great sporting memory is of Western Province beating the Sharks in the 2012 Currie Cup final in Durban.
This is a top memory for me because it's an underdog story.
While WP rugby are no strangers to the Currie Cup final – they had done it numerous times before in the past – we had not won the cup in 10 years. Also, we were up against a star studded Sharks outfit that didn't really look like losing.
But somehow we won. One player that sticks in my mind from that day is Demetri Catrakilis – as always, he was just ridiculously reliable off the kicking tee.
A particular memory that sticks here for me happened in the build-up when a close mate (a Sharks supporter) disclosed to me that he was very worried about the game. I found that bizarre but at full time I understood why.
So there you have it, those are my top sporting memories from my twenties.
One thing that you'll notice here is that my latest memory was from 2012. With that in mind, I think we can all agree that SA is the market for a new great sporting moment.
The good news is that the Rugby World Cup is fast approaching and I'll be there – doesn't that seem like just the perfect occasion to get my 30s off on the right foot? I think so.
Come on Bokke!!!
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Daniel Jay Rudolph (1949–2010) was a mathematician who was considered a leader in ergodic theory and dynamical systems. He studied at Caltech and Stanford and taught postgraduate mathematics at Stanford University, the University of Maryland and Colorado State University, being appointed to the Albert C. Yates Endowed Chair in Mathematics at Colorado State in 2005. He jointly developed a theory of restricted orbit equivalence which unified several other theories. He founded and directed an intense preparation course for graduate math studies and began a Math circle for middle-school children. Early in life he was a modern dancer. He died in 2010 from amyotrophic lateral sclerosis, a degenerative motor neuron disease.

Early life and education
Rudolph was born to William Franklin Rudolph (1922–2000) and Betty Johnalou Waldner (1921–2004). He was the second of three sons, the others being Gregory and James. The family moved to Fort Collins when Daniel was very young. He attended Fort Collins High School where he was active in the chemistry, physics, computer and flying clubs, and was on the student council. He was a semifinalist in the Westinghouse Science Talent Search.

He graduated from Fort Collins High School in 1968 and matriculated at the California Institute of Technology. He attended Caltech on a Sloan Research Fellowship, and planned to major in theoretical physics. He soon changed his mind and graduated with a bachelor's degree in mathematics in 1972. Before graduating he won Caltech's Bell Prize for Undergraduate Mathematics Research.

Career
Rudolph moved to Stanford University in 1972 where revolutionary work was being done on ergodic theory. He was awarded a Master of Science in 1973 and completed his PhD under the supervision of Don Ornstein in 1975, with the thesis "Non-Bernoulli Behavior of the Roots of K-automorphisms". His work in ergodic theory focused on measure theory, as opposed to the functional analysis approach that dominated ergodic theory.

His description of ergodic theory:

From August 1975 to August 1976, Rudolph was a postdoctoral fellow at the Hebrew University of Jerusalem, where he devised a solution to a problem in ergodic theory that had resisted solutions by Ornstein and others, entitled "When are two-point extensions of Bernoulli shifts also Bernoulli shifts?". In so doing he devised the method of "nesting" which evolved into a powerful tool. He also began his studies into varieties of orbit equivalence.

He became a fellow of the Miller Institute at U.C. Berkeley from late 1976 to 1978 and was appointed assistant professor at Stanford University from 1978 to 1981. He spent part of 1979 at the University of Maryland where he studied dynamics. At Maryland, he lived at "Ergodic House" with Bruce Kitchens, Brian Marcus and Laif Swanson; they were regularly visited by Doug Lind and Andres del Junco.

In 1981 Rudolph was appointed associate professor at the University of Maryland and was awarded a Sloan Research Fellowship. This is also where he became recognised as a world leader in ergodic theory. He was appointed professor of mathematics in 1985 and was at Maryland until 2004, at which time he was chair of the graduate program and acting chair of the Department of Mathematics.

In collaboration with Janet Kammeyer and others, Rudolph developed a theory of restricted orbit equivalence which unified Ornstein's Bernoulli theory, Dye's theorem, Kakutani equivalence, and other relations into a single framework.

Rudolph was also a Visiting Professor at several universities, including the Pierre and Marie Curie University (1988), the Mathematics Institute of the University of Warwick, Nicolaus Copernicus University in Toruń (1989), the University of North Carolina at Chapel Hill (1991), Université d'Aix-Marseille (1993); and Université de François Rabelais in Tours (1993).

He presented several lectures, including one at the 2002 International Congress of Mathematicians in Beijing, entitled "Applications of orbit equivalence to actions of discrete amenable groups".

Rudolph and his family moved to his hometown of Fort Collins in 2005, where he was appointed to the Albert C. Yates Endowed Chair in Mathematics at Colorado State University. There he was diagnosed with Amyotrophic lateral sclerosis, a degenerative motor neuron disease.

He founded and directed the SPIRAL program at Maryland, an intensive six-week preparation for graduate studies in mathematical sciences. It was acknowledged by the American Mathematical Society with an award for "Mathematics Programs That Make a Difference" in 2008.

As the disease progressed, some physical activities became impossible for Rudolph, but he continued to teach and do some departmental work, including supervising PhD students. He began a Math circle for middle school girls with the assistance of a middle school teacher, Martha Cranor. It was later expanded to a summer Math Circles camp for middle school girls and boys.

Rudolph died February 4, 2010, from complications from ALS. The April 2012 volume of the journal Ergodic Theory and Dynamical Systems (Vol 32, Part 2) was dedicated to him. One of his last papers was a joint work with Benjamin Weiss and Matthew Foreman in the journal Annals of Mathematics on the conjugacy equivalence relation of automorphisms.

Selected publications
Rudolph authored and co-authored more than 70 articles in ergodic theory, including:

He also authored two books:

Personal life
Before he got married, Rudolph had taken dance classes at as a Caltech undergraduate and at Maryland modern dancing became a serious hobby for him, after being inspired by dance innovator Alvin Mayes. In 1991, Mayes choreographed a duet "For Bill and Johnalou", dedicated to Rudolph's parents. In 1991 Rudolph married Michelle Hyde and they had three children, Beatrice, Jonah and Layton. "Rudolph was devoted to his children and evenings became a precious time to be spent with the children - no longer with friends or dance."

In November 1981 Rudolph's older brother Gregory, Gregory's wife Kristin and their two children died in a plane crash. The plane had been piloted by Gregory and had crashed while attempting to land at Cedar City Airport.

Rudolph was considered dynamic, inspiring and generally positive. For a while he kept a sign in his Maryland office that read "Eat problems for breakfast". His academic papers were considered difficult to read but in-person he expressed ideas elegantly. His students remembered him as "demanding but very supportive".

References

External links
 Daniel Jay Rudolph at the Mathematics Genealogy Project
 Caltech Mathematics Department prizes and awards (archive)
 Colorado State University memorial page for Daniel J. Rudolph

1949 births
2010 deaths
20th-century American mathematicians
California Institute of Technology alumni
Colorado State University faculty
Neurological disease deaths in Colorado
Deaths from motor neuron disease
Academic staff of the Hebrew University of Jerusalem
People from Fort Collins, Colorado
Stanford University alumni
Stanford University faculty
University of Maryland, College Park faculty
21st-century American mathematicians

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The Dramatist LIVE: Longstanding Collaborations, Part Two – The Charles Busch Edition
The live streamed format of our magazine aimed to inform, engage, delight and provide support for Guild members during the unprecedented time of the COVID-19 pandemic.
The July 2 Dramatist LIVE was all about playwright and performer, Charles Busch. His play, The Tale of the Allergist's Wife, is the longest running Broadway comedy of the past 25 years. But his career path has been unconventional, to say the least. "I didn't pursue the normal route," Busch explained in the webinar. "I always thought it was an adventure to put on a play in a strange place and just do it." In a frank and witty lightning round of Ten Questions LIVE, Busch revealed that he is terrified "of the blank page or the blank screen." He confronts his fear by writing down copious notes and then arranging them.
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D.Boche@soton.ac.uk
Professor Delphine Boche PhD
Professor of Neuroimmunopathology
Delphine Boche is a Professor of Neuroimmunopathology within Medicine at the University of Southampton. Her research focuses on understanding neuroinflammation and its consequences in patients affected by neurological disease. She was the recipient of a European Marie Curie Individual Fellowship (2000) and of a MRC New Investigator Award (2006).
Microglia, the Dr Jekyll and Mr Hyde of the brain
Her main interest is to develop a greater understanding of the role of neuroinflammation in relation with ageing, neurological diseases and systemic inflammation, using the complementary approaches of human brain analysis and animal models. Her work is located at the junction between clinical neurodegenerative disease, human neuropathology and experimental neuroscience where she has developed expertise in neuroimmunopathology.
Delphine serves on: (i) International grant review boards for France, Canada, Spain and Belgium including The Weston Brain Institute, US Alzheimer's Association, ERA-NET scheme of the European Commission, "La Caixa" Foundation; (ii) International editorial boards: Neuropathology and Applied Neurobiology, Scientific Reports; (iii) International conference committees: US Alzheimer's Association co-chair of the Scientific Program, International Society to Advance Alzheimer's Research and Treatment (ISTAART); (iv) Grant review boards: Alzheimer's Research UK, Hearing loss/ARUK, Wellcome Trust Cellular and Molecular Neuroscience Expert Review Group. Delphine sits on the BRAIN UK committee, Sheffield Brain bank committee, the Cambridge Brain Bank Committee and the British Neuropathological Society Academic committee. She was the external examiner for the MSc in Translational Neuropathology (Neuroscience) for Sheffield University (2015-2019). In 2014, as the co-chair of the Southampton Neuroscience Group (SoNG) - a platform for collaborative, interdisciplinary and applied neuroscience- she initiated the Spring Event and Prizes for the best neuroscience project delivered by an undergraduate and a master's students. Since 2019, Delphine is chair of the PostDoctoral Association with the aim to enhance the development of the Early Career Researchers (ECRs) and represents the Faculty Concordat Champion, ensuring that the Principles of the Concordat with a particular focus on ECRs are implemented within the Faculty.
BSc Cell Biology and Physiology, University Paris 12, France (1991)
MSc Cell Biology, University Paris 12, France (1992)
MRes Neurosciences, College de France and University 6, France (1993)
PhD in Neurosciences, University Paris 6, France (1997)
Fellow of the Higher Education Academy, UK (2010)
Appointments held
Bourse Roux (Fellowship) Institut Pasteur Paris (France): 1998-1999
Marie Curie Fellow (European Community), School of Biological Sciences, University of Southampton (UK): 2000-2001
Post-Doctoral Research Fellow, School of Biological Sciences, University of Southampton (UK): 2001-2004
Post-Doctoral Research Fellow, School of Medicine, University of Southampton (UK): 2004-2006
MRC New Investigator, School of Medicine, University of Southampton (UK): 2006-2009
Lecturer, Faculty of Medicine, University of Southampton (UK): 2009-2013
Associate Professor, Faculty of Medicine, University of Southampton (UK): 2013-2017
Professor of Neuroimmunopathology, Faculty of Medicine, University of Southampton (UK): 2017-present
Delphine serves as PI and Co-PI on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration. Her research investigates the role of microglia, the immune cells of the brain, in neurodegenerative diseases using the complementary approaches of human brain tissue analysis and animal models.
Immunophenotyping microglia in neurological conditions such as: Alzheimer's disease, dementia with Lewy bodies, Frontotemporal dementia, schizophrenia, glioblastoma
Neuroinflammation in age-related dementia
Exploring the impact of systemic inflammation on the brain pathology and inflammation
Aβ immunotherapy in human Alzheimer's disease
Department(s)
Clinical and Experimental Sciences
Affiliate Department(s)
Clinical Neuroscience Research group
International grant review boards
Agence Nationale de la Recherche (French governmental Agency for Scientific Research) – Member of the Scientific Committee section Neuroscience CES16 (2021 on)
Member of the Research Foundation – Flanders (FWO) Review College (2021-2023)
The Royal Society - Member of the Society's Newton International Fellowships Committee: Biological Sciences (2021-2023)
"La Caixa" Foundation Health Research Selection Committee - Neuroscience High Level Expert panel (Spain, 2020)
"Network of European Funding for Neuroscience Research" (NEURON) under the ERA-NET scheme of the European Commission, Member of the Peer Review Panel for the "Transnational Research Projects on Mental Disorders" call (2018)
Canadian Weston Brain Institute, grant review panel (2015 on)
US Alzheimer's Association, Canadian Weston Brain Institute and Alzheimer's Research UK joint grant review panel for "Mechanisms of Cellular Death in Neurodegeneration" (MCDN) call (2015)
International editorial boards
Frontiers in Neuroscience – Neurodegeneration and Molecular Neuroscience, Review Editor (2018 on)
Scientific Reports (Neurology, Nature Publishing Group), Editorial Board (2015 on)
Neuropathology and Applied Neurobiology, Editorial Board (2015 on)
Brain Pathology, Senior Editor, special review issue on the "Inflammasome" (2017)
Neuropathology and Applied Neurobiology, Guest Editor, special review issue on "Neuroinflammation in ageing and neurodegenerative disease" (2013)
International conference committees
US Alzheimer's Association, Co-chair of the Scientific Program Committee, International Conference (2019 on)
US Alzheimer's Association, Lead for the "Basic and Translational Science" Theme, Scientific Program Committee, International Conference (2017-2019)
US Alzheimer's Association, International Society to Advance Alzheimer's Research and Treatment (ISTAART), Executive Committee member of the Professional Interest Area "Immunity and Neurodegeneration" (2015 on)
The Alzheimer's Disease Congress, Advisory Board (2014-2015)
International (other activities)
European Alzheimer's Disease Consortium, Southampton lead (2013-2018)
International Conference on Alzheimer's Disease (ICAD), selected for media/press presentation (2010)
Nominated expert for: US Alzheimer's Association; France Alzheimer; "Agence Nationale de la Recherche"; Israel Science Foundation; Research Foundation Flanders (FWO), Hong Kong Council, L'Oreal-UNESCO, National University of Singapore.
National grant review boards
Wellcome Trust Cellular and Molecular Neuroscience Expert Review Group (2020)
Action of Hearing Loss - Alzheimer's Research UK, Grant Review Board (2018 on)
Medical Research Council, Grant Review Board for the "Human Cell Atlas" Initiative (2018)
Alzheimer's Research UK, Grant Review Board (2016 on)
Alzheimer's Society, UK, PhD review panel (2015-2018)
National Examining
External Examiner, MSc in Translational Neuropathology (Neuroscience), Faculty of Medicine, Dentistry and Health, University of Sheffield (2015-2019)
BRAIN UK User Representative on the Committee (2019 on)
British Neuropathological Society Academic Committee (2018 on)
Sheffield Brain bank, Committee member (2018 on)
UK Brains for Dementia Research, Steering Committee member (2014-2018)
The Cambridge Brain Bank, University of Cambridge, Committee member (2014 on)
Alzheimer's Research UK National Network, South Coast Regional Chair (2008-2014), included hosting the national conference in Southampton (2010)
University of Southampton, Faculty of Medicine, Chair of the PostDoctoral Association Steering Committee (2019 on)
University of Southampton, Faculty of Medicine, Concordat Champion (2019 on)
University of Southampton, Southampton Neurosciences Group (SoNG), co-chair, (2013-2016)
External Examiner, MSc in Translational Pathology (Neuroscience), Faculty of Medicine, Dentistry and Health, University of Sheffield (2015-2019)
35 BMEdSc
21 MMEdSc / MSc
7 PhD
7 Academic Clinical Fellows completed
11 International visitors
Lopez-Rodriguez, A. B., Hennessy, E., Murray, C., Nazmi, A., Delaney, H. J., Healy, D., Fagan, S., Rooney, M., Stewart, E., Lewis, A., de Barra, N., Scarry, P., Riggs-Miller, L., Boche, D., Cunnigham, M., & Cunnigham, C. (Accepted/In press). Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's Disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction. Alzheimer's & Dementia, [ADJ-D-18-00596R2].
De Picker, L., Mendez-Victoriano, G., Richards, R., Gorvett, A., Lyons, S., Buckland, G., Tofani, T., Norman, J., Chatelet, D., Nicoll, J., & Boche, D. (2021). Immune environment of the brain in schizophrenia and during the psychotic episode: a human post-mortem study. Brain, Behavior and Immunity, 97, 319-327. [BBI-D-21-00220R2 ]. https://doi.org/10.1016/j.bbi.2021.07.017
Shatya, A., Bridges, L., Williams, R., Trippier, S., Zhang, L., Pereira, A. C., Nicoll, J., Boche, D., & Hainsworth, A. (2021). Innate immune anti-inflammatory response in human spontaneous intracerebral haemorrhage. Stroke, 3613-3623. [STROKE/2021/034673DR1]. https://doi.org/10.1161/STROKEAHA.121.034673
Galea, I., Durnford, A., Glazier, J., Mitchell, S., Kohli, S., Foulkes, L., Norman, J., Darekar, A., Love, S., Bulters, D., Nicoll, J., & Boche, D. (Accepted/In press). Iron deposition in the brain after aneurysmal subarachnoid haemorrhage. Stroke.
Tzioras, M., Stevenson, A. J., Boche, D., & Spires-Jones, T. L. (2021). Microglial contribution to synaptic uptake in the prefrontal cortex in schizophrenia. Neuropathology and Applied Neurobiology, 47(2), 346-351. https://doi.org/10.1111/nan.12660
Asby, D. J., Boche, D., Allan, S., Love, S., & Miners, S. (Accepted/In press). Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease. Brain, [BRAIN-2020-01836.R1].
Amin, J., Holmes, C., Dorey, R. B., Tommasino, E., Reis Casal, Y., Williams, D., Dupuy, C., Nicoll, J., & Boche, D. (2020). Neuroinflammation in dementia with Lewy bodies: a human post-mortem study. Translational Psychiatry, 10(1), 1-11. [267]. https://doi.org/10.1038/s41398-020-00954-8
Amin, J., Boche, D., Clough, Z., Teeling, J., Williams, A., Gao, Y., Chudley, L., Lau, L., Smith, F., Harris, S., & Holmes, C. (2020). Peripheral immunophenotype in Dementia with Lewy bodies and Alzheimer's disease: an observational clinical study. Journal of Neurology, Neurosurgery & Psychiatry, 91(11), 1219-1226. https://doi.org/10.1136/jnnp-2020-323603
Jäkel, L., Boche, D., Nicoll, J. A. R., & Verbeek, M. M. (2019). Aβ43 in human Alzheimer's disease: effects of active Aβ42 immunization. Acta Neuropathologica Communications, 7(1), 1-11. https://doi.org/10.1186/s40478-019-0791-6
Franco Bocanegra, D. K., George, B., Lau, L. C., Holmes, C., Nicoll, J. A. R., & Boche, D. (2019). Microglial motility in Alzheimer's disease and after Aβ42 immunotherapy: a human post-mortem study. Acta Neuropathologica Communications, 7(1), 174. https://doi.org/10.1186/s40478-019-0828-x
Nicoll, J. A. R., Buckland, G. R., Harrison, C. H., Page, A., Harris, S., Love, S., Neal, J. W., Holmes, C., & Boche, D. (2019). Persistent neuropathological effects 14 years following amyloid-β immunisation in Alzheimer's disease. Brain, 142(7), 2113-2126. https://doi.org/10.1093/brain/awz142
Shtaya, A., Bridges, L. R., Esiri, M. M., Lam-Wong, J., Nicoll, J. A. R., Boche, D., & Hainsworth, A. H. (2019). Rapid neuroinflammatory changes in human acute intracerebral haemorrhage. Annals of Clinical and Translational Neurology, 6(8), 1465-1479. https://doi.org/10.1002/acn3.50842
Harrison, C. H., Buckland, G. R., Brooks, S. E., Johnston, D. A., Chatelet, D. S., Liu, A. K. L., Gentleman, S. M., Boche, D., & Nicoll, J. A. R. (2018). Brief communication. A novel method to visualise the three-dimensional organisation of the human cerebral cortical vasculature. Journal of Anatomy, 1-6. https://doi.org/10.1111/joa.12805
Taga, M., Mouton-Liger, F., Sadoune, M., Gourmaud, S., Norman, J., Tible, M., Thomasseau, S., Paquet, C., Nicoll, J., Boche, D., & Hugon, J. (2018). PKR modulates abnormal brain signaling in experimental obesity. PLoS ONE, 13(5), [e0196983]. https://doi.org/10.1371/journal.pone.0196983
Moro, M., Phillips, A. S., Gaimster, K., Paul, C., Mudher, A., Nicoll, J., & Boche, D. (2018). Pyroglutamate and isoaspartate modified amyloid-beta in ageing and Alzheimer's disease. Acta Neuropathologica Communications, 6(3), 1-39. https://doi.org/10.1186/s40478-017-0505-x
Rakic, S., Hung, Y. M. A., Smith, M., So, D., Tayler, H., Varney, W., Wild, J., Harris, S., Holmes, C., Love, S., Stewart, W., Nicoll, J., & Boche, D. (2018). Systemic infection modifies the neuroinflammatory response in late stage Alzheimer's disease. Acta Neuropathologica Communications, 6(88). https://doi.org/10.1186/s40478-018-0592-3
Fahrenhold, M., Rakic, S., Classey, J., Brayne, C., Ince, P. G., Nicoll, J. A. R., & Boche, D. (2018). TREM2 expression in the human brain: a marker of monocyte recruitment? Brain Pathology, 28(5), 595-602. https://doi.org/10.1111/bpa.12564
Paquet, C., Nicoll, J., Love, S., Mouton-Liger, F., Holmes, C., Hugon, J., & Boche, D. (2017). Downregulated apoptosis and autophagy after anti-Aβ immunotherapy in Alzheimer's disease. Brain Pathology. https://doi.org/10.1111/bpa.12567
Paquet, C., Boche, D., El Bouchtaoui, M., Gourmaud, S., Janin, A., & Bousquet, G. (2017). Effect of anti-cancer drugs on microglia in patient-derived breast cancer xenografted mouse models. Neuropathology, 1-3. https://doi.org/10.1111/neup.12323
Franco Bocanegra, D. K., Nicoll, J. A. R., & Boche, D. (2017). Innate immunity in Alzheimer's disease: the relevance of animal models? Journal of Neural Transmission, 20. [JONT-D-16-00259R1]. https://doi.org/10.1007/s00702-017-1729-4
Boche, D., & Brough, D. (2017). Role of the inflammasome in brain pathogenesis: a potential therapeutic target? Brain Pathology, 27(2), 190-191. https://doi.org/10.1111/bpa.12481
Amin, J., Boche, D., & Rakic, S. (2017). What do we know about the inflammasome in humans? Brain Pathology, 27(2), 192-204. https://doi.org/10.1111/bpa.12479
Taga, M., Minett, T., Classey, J., Matthews, F., Brayne, C., Ince, P., Nicoll, J., Hugon, J., & Boche, D. (2016). Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology? Brain Pathology, 27(3), 226-275. https://doi.org/10.1111/bpa.12388
Minett, T., Classey, J., Matthews, F. E., Fahrenhold, M., Taga, M., Brayne, C., Ince, P. G., Nicoll, J., & Boche, D. (2016). Microglial immunophenotype in dementia with Alzheimer's pathology. Journal of Neuroinflammation, 13, [135]. https://doi.org/10.1186/s12974-016-0601-z
Garland, P., Durnford, A. J., Okemefuna, A. I., Dunbar, J., Nicoll, J. A. R., Galea, J., Boche, D., Bulters, D. O., & Galea, I. (2016). The heme-hemopexin scavenging system is active in the brain, and associates with outcome after subarachnoid hemorrhage. Stroke, 47(3), 872-876. https://doi.org/10.1161/STROKEAHA.115.011956
Paquet, C., Amin, J., Mouton-Liger, F., Nasser, M., Love, S., Gray, F., Pickering, R. M., Nicoll, J. A. R., Holmes, C., Hugon, J., & Boche, D. (2015). Effect of active Abeta immunotherapy on neurons in human Alzheimer's disease. The Journal of Pathology, 235(5), 721-730. https://doi.org/10.1002/path.4491
Amin, J., Paquet, C., Baker, A., Asuni, A. A., Love, S., Holmes, C., Hugon, J., Nicoll, J. A. R., & Boche, D. (2015). Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β. Neuropathology and Applied Neurobiology, 41(4), 445-457. https://doi.org/10.1111/nan.12205
Durnford, A., Dunbar, J., Galea, J., Bulters, D., Nicoll, J. A. R., Boche, D., & Galea, I. (2015). Haemoglobin scavenging after subarachnoid haemorrhage. Acta Neurochirurgica Supplement, 120, 51-54. https://doi.org/10.1007/978-3-319-04981-6_9
De Lucia, C., Rinchon, A., Olmos-Alonso, A., Riecken, K., Fehse, B., Boche, D., Perry, H., & Gomez-Nicola, D. (2015). Microglia regulate hippocampal neurogenesis during chronic neurodegeneration. Brain, Behavior and Immunity, 1-36. https://doi.org/10.1016/j.bbi.2015.11.001
Noorani, I., Petty, G., Grundy, P. L., Sharpe, G., Willaime-Morawek, S., Harris, S., Thomas, G. J., Nicoll, J. AR., & Boche, D. (2015). Novel association between microglia and stem cells in human gliomas: a contributor to tumour proliferation? The Journal of Pathology: Clinical Research, 1(2), 67-75. https://doi.org/10.1002/CJP2.7
Gomez-Nicola, D., & Boche, D. (2015). Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease. Alzheimer's Research & Therapy, 7(42), 1-8. https://doi.org/10.1186/s13195-015-0126-1
Sakai, K., Boche, D., Carare, R., Johnston, D., Holmes, C., Love, S., & Nicoll, J. A. R. (2014). Aβ immunotherapy for Alzheimer's disease: effects on apoE and cerebral vasculopathy. Acta Neuropathologica, 128(6), 777-789. https://doi.org/10.1007/s00401-014-1340-9
Zotova, E., Bharambe, V., Cheaveau, M., Morgan, W., Holmes, C., Harris, S., Neal, J. W., Love, S., Nicoll, J. A. R., & Boche, D. (2013). Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization. Brain, 136(9), 2677-2696. https://doi.org/10.1093/brain/awt210
Proctor, C. J., Boche, D., Gray, D. A., & Nicoll, J. A. R. (2013). Investigating interventions in Alzheimer's disease with computer simulation models. PLoS ONE, 8(9), e73631. https://doi.org/10.1371/journal.pone.0073631
Boche, D., & Nicoll, J. A. R. (2013). Neuroinflammation in ageing and in neurodegenerative disease. Neuropathology and Applied Neurobiology, 39(1), 1-2. https://doi.org/10.1111/nan.12009
Boche, D., Perry, V. H., & Nicoll, J. A. R. (2013). Review. Activation patterns of microglia and their identification in the human brain. Neuropathology and Applied Neurobiology, 39(1), 3-18. https://doi.org/10.1111/nan.12011
Billingham, C., Powell, M. R., Jenner, K. A., Johnston, D. A., Gatherer, M., Nicoll, J. A. R., & Boche, D. (2012). Rat astrocytic tumour cells are associated with an anti-inflammatory microglial phenotype in an organotypic model. Neuropathology and Applied Neurobiology. https://doi.org/10.1111/j.1365-2990.2012.01283.x
Galea, J., Cruickshank, G., Teeling, J. L., Boche, D., Garland, P., Perry, V. H., & Galea, I. (2012). The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage. Journal of Neurochemistry, 121(5), 785-792. https://doi.org/10.1111/j.1471-4159.2012.07716.x
Zotova, E., Holmes, C., Johnston, D., Neal, J. W., Nicoll, J. A. R., & Boche, D. (2011). Microglial alterations in human Alzheimer's disease following Aβ42 immunization. Neuropathology and Applied Neurobiology, 37(5), 513-524. https://doi.org/10.1111/j.1365-2990.2010.01156.x
Boche, D., & Nicoll, J. A. R. (2010). Are we getting to grips with Alzheimer's disease at last? Brain, 133(5), 1297-1299. https://doi.org/10.1093/brain/awq099
Zotova, E., Nicoll, J. A. R., Kalaria, R., Holmes, C., & Boche, D. (2010). Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy. Alzheimer's Research & Therapy, 2(1), 1-9. https://doi.org/10.1186/alzrt24
Boche, D., Denham, N., Holmes, C., & Nicoll, J. A. R. (2010). Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis. Acta Neuropathologica, 120(3), 369-384. https://doi.org/10.1007/s00401-010-0719-5
Boche, D., Donald, J., Love, S., Harris, S., Neal, J. W., Holmes, C., & Nicoll, J. A. R. (2010). Reduction of aggregated Tau in neuronal processes but not in the cell bodies after AB42 immunisation in Alzheimer's disease. Acta Neuropathologica, 120(1), 13-20. https://doi.org/10.1007/s00401-010-0705-y
Weller, R. O., Boche, D., & Nicoll, J. A. R. (2009). Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy. Acta Neuropathologica, 118(1), 87-102. https://doi.org/10.1007/s00401-009-0498-z
Nicoll, J., Boche, D., & Holmes, C. (2008). Amyloid-beta vaccination for Alzheimer's dementia - Authors' reply. Evidence-Based Complementary and Alternative Medicine , 372(9647), 1381-1382. https://doi.org/10.1016/S0140-6736(08)61580-9
Boche, D., Zotova, E., Weller, R. O., Love, S., Neal, J. W., Pickering, R. M., Wilkinson, D., Holmes, C., & Nicoll, J. A. R. (2008). Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain, 131(12), 3299-3310. https://doi.org/10.1093/brain/awn261
Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R. W., Bullock, R., Love, S., Neal, J. W., Zotova, E., & Nicoll, J. A. R. (2008). Long-term effects of Abeta(42) immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet, 372(9634), 216-223. https://doi.org/10.1016/S0140-6736(08)61075-2
Boche, D., & Nicoll, J. A. R. (2008). The role of the immune system in clearance of Abeta from the brain. Brain Pathology, 18(2), 267-278. https://doi.org/10.1111/j.1750-3639.2008.00134.x
Nicoll, J. A. R., Barton, E., Boche, D., Neal, J. W., Ferrer, I., Thompson, P., Vlachouli, C., Wilkinson, D., Bayer, A., Games, D., Seubert, P., Schenk, D., & Holmes, C. (2006). Aβ species removal after Aβ42 immunization. Journal of Neuropathology & Experimental Neurology, 65(11), 1040-1048. https://doi.org/10.1097/01.jnen.0000240466.10758.ce
Boche, D., Nicoll, JAR., & Weller, RO. (2006). Immunotherapy for Alzheimer's disease and other dementias. Clinical Neuropharmacology, 29(1), 22-27.
Boche, D., Cunningham, C., Docagne, F., Scott, H., & Perry, VH. (2006). TGF-beta1 regulates the inflammatory response during chronic neurodegeneration. Neurobiology of Disease, 22(3), 638-650. https://doi.org/10.1016/j.nbd.2006.01.004
Cunningham, C., Wilcockson, DC., Boche, D., & Perry, VH. (2005). Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease. Journal of Virology, 79(8), 5174-5184. https://doi.org/10.1128/JVI.79.8.5174-5184.2005
Boche, D., Nicoll, JAR., & Weller, RO. (2005). Immunotherapy for Alzheimer's disease and other dementias. Current Opinion in Neurology, 18(6), 720-725.
Galea, I., Palin, K., Newman, T. A., Van Rooijen, N., Perry, V. H., & Boche, D. (2005). Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain. GLIA, 49(3), 375-384. https://doi.org/10.1002/glia.20124
Felton, LM., Cunningham, C., Rankine, EL., Waters, S., Boche, D., & Perry, VH. (2005). MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease. Neurobiology of Disease, 20(2), 283-295. https://doi.org/10.1016/j.nbd.2005.03.008
Cunningham, C., Deacon, RMJ., Chan, K., Boche, D., Rawlins, JNP., & Perry, VH. (2005). Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits. Neurobiology of Disease, 18(2), 258-269. https://doi.org/10.1016/j.nbd.2004.08.015
Picanço-Diniz, CW., Boche, D., Gomes-Leal, W., Perry, VH., & Cunningham, C. (2004). Neuropil and neuronal changes in hippocampal NADPH-diaphaorase histochemistry in the ME7 model of murine prion disease. Neuropathology and Applied Neurobiology, 30(3), 292-303. https://doi.org/10.1111/j.1365-2990.2004.00537.x
Cunningham, C., Deacon, R., Wells, H., Boche, D., Waters, E., Picanco Diniz, C., Scott, H., Rawlins, JNP., & Perry, VH. (2003). Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease. European Journal of Neuroscience, 17(10), 2147-2155. https://doi.org/10.1046/j.1460-9568.2003.02662.x
Boche, D., Cunningham, C., Gauldie, J., & Perry, VH. (2003). Transforming growth factor-beta1-mediated neuroprotection against excitotoxic injury in vivo. Journal of Cerebral Blood Flow and Metabolism, 23(10), 1174-1182. https://doi.org/10.1097/01.WCB.0000090080.64176.44
Perry, VH., Cunningham, C., & Boche, D. (2002). Atypical inflammation in the central nervous system in prion disease. Current Opinion in Neurology, 15(3), 349-354.
Cunningham, C., Boche, D., & Perry, VH. (2002). Transforming growth factor-beta1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix. Neuropathology and Applied Neurobiology, 28(2), 107-119. https://doi.org/10.1046/j.1365-2990.2002.00383.x
Chrétien, F., Boche, D., De La Grandmaison, G. L., Ereau, T., Mikol, J., Hurtrel, M., Hurtrel, B., & Gray, F. (2000). Progressive multifocal leukoencephalopathy and oligodendroglioma in a monkey co-infected by simian immunodeficiency virus and simian virus 40. Acta Neuropathologica, 100(3), 332-336. https://doi.org/10.1007/s004010050031
Boche, D., Khatissian, E., Gray, F., Falanga, P., Montagnier, L., & Hurtrel, B. (1999). Viral load and neuropathology in the SIV model. Journal of Neurovirology, 5(3), 232-240. https://doi.org/10.3109/13550289909015809
Boche, D., Gray, F., Khatissian, E., Hurtrel, M., Montagnier, L., & Hurtrel, B. (1997). Apport des modeles animaux dans la comprehension de l'encephalopathie SIDA. Archives d'Anatomie et de Cytologie Pathologiques, 45(2-3), 75-85.
Boche, D., Hurtrel, M., Gray, F., Claessens-Maire, M. A., Ganière, J. P., Montagnier, L., & Hurtrel, B. (1996). Virus load and neuropathology in the FIV model. Journal of Neurovirology, 2(6), 377-387. https://doi.org/10.3109/13550289609146903
Boche, D., Gray, F., Chakrabarti, L., Hurtrel, M., Montagnier, L., & Hurtrel, B. (1995). Low susceptibility of resident microglia to simian immunodeficiency virus replication during the early stages of infection. Neuropathology and Applied Neurobiology, 21(6), 535-539. https://doi.org/10.1111/j.1365-2990.1995.tb01100.x
Denham, N. C., Nicoll, J. A. R., & Boche, D. (2011). Synapses and Alzheimers's disease: effect of immunotherapy? In A. Wyttenbach, & V. O'Connor (Eds.), Folding for the Synapse (pp. 269-287). Springer. https://doi.org/10.1007/978-1-4419-7061-9_14
Weller, R. O., Carare, R. O., & Boche, D. (2009). Amyloid: Vascular and parenchymal. In L. R. Squire (Ed.), Encyclopedia of Neuroscience (pp. 355-362). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00105-4
Weller, R. O., Carare, R., & Boche, D. (2008). Ageing and the accumulation of amyloid in brain parenchyma and blood vessel walls in Alzheimer's disease. In L. R. Squire (Ed.), New Encyclopedia of Neuroscience Elsevier.
Boche, D. (2004). Comprehension du role de la microglie dans les maladies neurodegeneratives a l'aide du modele animal [Understanding the role of microglia in neurodegenerative diseases using the animal model]. In G. Guillemin (Ed.), Cellules microgliales (pp. 106-111). (Neuroanatomie fonctionnelle, de la cellule aux comportements; Vol. 7). Association de la Neuro-Psycho-Pharmacologie (ANPP).
Hurtrel, B., & Boche, D. (2000). Physiopathologie et modeles animaux de l'infection du systeme nerveux central par le VIH [Pathophysiology and animal models of central nervous system infection by HIV]. In S. Mrejen, & A. Moulignier (Eds.), Atteintes neurologiques et infection par le VIH Flammarion.
Amin, J., Williams, T., Teeling, J., Dorey, R., Williams, D., Tommasino, E., Boche, D., & Holmes, C. (2017). Central and systemic inflammation in Dementia with Lewy bodies and Alzheimer's disease. Neuropathology and Applied Neurobiology, 43(S1), 12-13. [O04]. https://doi.org/10.1111/nan.12382
Amin, J., Williams, T., Teeling, J., Dorey, R., Williams, D., Tommasino, E., Holmes, C., & Boche, D. (2017). Inflammation in Dementia with Lewy bodies. Alzheimer's & Dementia, 13(7, Supplement), P594-P595. https://doi.org/10.1016/j.jalz.2017.07.232
Amin, J., Boche, D., Holmes, C., Williams, A., Teeling, J., & Nicoll, J. (2016). Central and systemic inflammation in Dementia with Lewy Bodies and Alzheimer's disease. Neuropathology and Applied Neurobiology, 42(S1), 36-36. https://doi.org/10.1111/nan.12306
Boche, D., Amin, J., Mouton-Liger, F., Nasser, M., Hugon, J., Nicoll, J. A. R., & Paquet, C. (2014). Effect of active A beta immunotherapy on neocortical neurons in Alzheimer's disease. Neuropathology and Applied Neurobiology, 40, 32-32.
Boche, D., Amin, J., Mouton-Liger, F., Nasser, M., Love, S., Gray, F., Pickering, R., Nicoll, J., Holmes, C., Hugon, J., & Paquet, C. (2013). Consequences of beta‐amyloid immunotherapy for Alzheimer's disease on neurons in the human cerebral cortex. Alzheimer's & Dementia, 9(4S, Part 7), P284. https://doi.org/10.1016/j.jalz.2013.05.571
Boche, D., Holmes, C., Wilkinson, D., Hopkins, V., Bayer, A., Jones, R., Bullock, R., Love, S., Neal, J., Yadegarfar, G., Zotova, E., & Nicoll, J. A. R. (2008). Continued progression of neurodegeneration in Alzheimer's disease despite complete removal of the Abeta plaques?. 1. Abstracts of the 109th Meeting of the British Neuropathological Society, . https://doi.org/10.1111/j.1365-2990.2007.00921.x
Zotova, E., Holmes, C., Nicoll, J. A., & Boche, D. (2008). Microglia activation in Alzheimer's disease after Abeta immunization: good or bad?. 216. Paper presented at 9th International Congress of Neuroimmunology, . https://doi.org/10.1016/j.jneuroim.2008.08.001
Boche, D., Bridges, L., Neal, J., Wilkinson, D., Holmes, C., Love, S., Esiri, M. M., & Nicoll, J. A. R. (2007). Variability of Abeta removal after Abeta42 immunization in Alzheimer's disease. 252. Paper presented at Abstracts of the 108th Meeting of the British Neuropathological Society, . https://doi.org/10.1111/j.1365-2990.2007.00837.x
Weller, R. O., Carare-Nnadi, R., Yow, H. Y., Boche, D., Mazanti, I., Bridges, L. R., Perry, V. H., & Nicoll, J. A. (2006). Cerebrovascular disease impedes the perivascular elimination of amyloid-beta from the brain in Alzheimer's disease. S79. Paper presented at XVIth Congress of the International Society of Neuropathology, United States. https://doi.org/10.1111/j.1750-3639.2006.00019.x
Boche, D., Barton, E., Neal, J., Ferrer, I., Wilkinson, D., Bayer, A., Holmes, C., Weller, R. O., & Nicoll, J. A. R. (2006). Effects of Abeta immunotherapy on cerebral amyloid angiopathy in Alzheimer's disease. 223-224. Paper presented at Proceedings of the 107th Meeting of the British Neuropathological Society, United Kingdom. https://doi.org/10.1111/j.1365-2990.2006.00749.x
Bridges, L. R., Boche, D., Neal, J., Love, S., Esiri, M., Wilkinson, D., Holmes, C., & Nicoll, J. (2006). Immunization with Abeta42 results in variable clearance of Abeta plaques in Alzheimer's disease. S81. Paper presented at XVIth Congress of the International Society of Neuropathology, United States. https://doi.org/10.1111/j.1750-3639.2006.00019.x
Boche, D., Holmes, C., Perry, VH., Vlachouli, C., Thompson, P., & Nicoll, J. A. R. (2006). Neuroinflammation and Alzheimer's disease: implications of Abeta immunotherapy. 267-268. Paper presented at 8th International Conference of Neuroimmunology (ISNI 2006), . https://doi.org/10.1016/j.jneuroim.2006.07.002
Felton, L. M., Cunningham, C., Rankine, E. L., Waters, S., Boche, D., & Perry, V. H. (2005). MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease. S51. Paper presented at Abstracts of the XVIIIth World Congress of Neurology, . https://doi.org/10.1016/S0022-510X(05)80203-5
Boche, D., Cunningham, C., Scott, H., & Perry, V. H. (2002). TGF-beta1 and murine prion disease. S27. Paper presented at Fifth European Meeting on Glial Cell Function in Health and Disease (Euroglia 2002), . https://doi.org/10.1002/glia.6002
Nicoll, J., Bloom, T., Clarke, A., Boche, D., & Hilton, D. (2021). BRAIN UK: accessing NHS tissue archives for neuroscience research. Neuropathology and Applied Neurobiology, [NAN12766]. https://doi.org/10.1111/nan.12766
Boche, D., & Gordon, M. (2021). Diversity of transcriptomic microglial phenotypes in aging and Alzheimer's disease. Alzheimer's & Dementia, [ADJ-D-20-01327R2].
Beardmore, R. C., Hou, R., Darekar, A., Holmes, C., & Boche, D. (Accepted/In press). The Locus Coeruleus in Aging and Alzheimer's Disease: A post-mortem and brain imaging review. Journal of Alzheimer's Disease, 83(1), 5-22. [21-0191R2]. https://doi.org/10.3233/JAD-210191
Hartnell, I., Blum, D., Nicoll, J., Dorothee, G., & Boche, D. (Accepted/In press). Glial cells and adaptive immunity in frontotemporal dementia with tau pathology. Brain.
Ashford, B. A., Boche, D., Cooper-Knock, J., Heath, P. R., Simpson, J. E., & Highley, J. R. (Accepted/In press). Microglia in Motor Neuron Disease. Neuropathology and Applied Neurobiology, [NAN-2020-0025.R2].
Boche, D., & Nicoll, J. (Accepted/In press). Understanding cause and effect in Alzheimer's pathophysiology: implications for clinical trials. Neuropathology and Applied Neurobiology.
Sehlin, D., Syvänen, S., & on behalf of the MINC faculty (2019). Engineered antibodies: new possibilities for brain PET? European Journal of Nuclear Medicine and Molecular Imaging, 46(13), 2848-2858. https://doi.org/10.1007/s00259-019-04426-0
Franco-Bocanegra, D. K., McAuley, C., Nicoll, J., & Boche, D. (2019). Molecular mechanisms of microglial motility: changes in ageing and Alzheimer's disease. Cells, 8(6). https://doi.org/10.3390/cells8060639
Boche, D., Gerhard, A., & Rodriguez-Vieitez, E. (2019). Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging, 1-17. https://doi.org/10.1007/s00259-019-04462-w
De Picker, L. J., Morrens, M., Chance, S. A., & Boche, D. (2017). Microglia and brain plasticity in acute psychosis and schizophrenia illness course: a meta-review. Frontiers in Psychiatry, 8, 238. [276071]. https://doi.org/10.3389/fpsyt.2017.00238
Gray, F., Scaravilli, F., Everall, I., Chretien, F., An, S., Boche, D., Adle-Biassette, H., Wingertsmann, L., Durigon, M., Hurtrel, B., Chiodi, F., Bell, J., & Lantos, P. (1996). Neuropathology of early HIV-1 infection. Brain Pathology, 6(1), 1-15. https://doi.org/10.1111/j.1750-3639.1996.tb00775.x
BM5. Lectures on the Locomotor & Nervous Systems Courses
BM4. Facilitator
BIOL3037/BIOL6038 Immunology. Lectures on Neuroimmunology
BMedSc/MMedSc. project supervisor
BIOL6084. Workpackage on Human Neuropathology and Brain Banks
BIOL6092. MSc Neuroscience Research Project
Personal Academic Tutor for students
Professor Delphine Boche
Faculty of Medicine Clinical and Experimental Sciences University of Southampton Southampton General Hospital Mailpoint 806 Southampton SO16 6YD
Room Number: SGH/LD62/MP806
Telephone:(023) 8120 6085
Email:D.Boche@soton.ac.uk


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Neeraj to spearhead 22-member Indian team at World Athletics
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'They won't be affected at all by loss of money or points. They are all chasing each other on number of Grand Slams as they have legacies already in place.' IMAGE: Novak Djokovic, Rafael Nadal and......
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How the 22-year-old Indian reached the Show Court at US Open, finding himself against 20-time Grand Slam Champion Roger Federer after beginning the year outside 350. IMAGE: While Sumit Nagal has......


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Exploring Fun Activities at YCIS Beijing Primary Summer Camp
The YCIS Beijing Summer Camp is officially underway and our Primary school students are immersed in an array of activities designed to not only entertain them, but also encourage them to explore new interests, learn in detail about specific topics and give them a chance to mingle with students in different year levels and interact with teachers they do not frequently come in contact with.
Journeying Back to Beijing with Hayley Edge
When Hayley Edge, YCIS Bejing Head of Humanities and Secondary School Coordinator, left Beijing for a holiday in January, never did she imagine she would be living from her suitcase in four countries and 15 different accommodations. Approximately seven months later, her penchant for travelling may be less after this experience, but she certainly will have entertaining stories to share with colleagues once she is back in Beijing.
Chefs' Hats Are on at YCIS Beijing Summer Camp
Food, just like music, has the power to unite people in a way that nothing else can. It has been evident in the YCIS Beijing Primary Summer Programme cooking classes, which are 50-minutes sessions led by Ms Freda Humber, Drama Teacher and Bethany Adams, Year 1 Teacher. Both teachers opted to teach a cooking class based on several reasons. The motivation for both, however, was to develop students' confidence working in the kitchen, introduce them to different flavours and acquire other skills while enjoying their creations.
Meet our New School Vice Principal
As announced by our CEO and School Supervisor, Dr Betty Chan , before the end of the last semester, our former Vice Principal, Head of Primary School, Mr James Sweeney, has been appointed as the new School Vice Principal on the School Leadership Team (SLT) at Yew Chung International School of Beijing. Starting from August 1st, Mr Sweeney will be working together with his fellow SLT members, Dr Rae Wang and Ms Fanny Du, to oversee the smooth running and continual enhancements of our Honglingjin campus.
Five Fun Activities to Keep Children Busy this Summer
The summer holiday is usually met with the excitement of planning vacations abroad or locally for families in our community - especially after a gruelling academic year. The unpredictable nature of 2020, however, and the closing of borders prompted parents to come up with creative ways to entertain families while in Mainland. This rings true to the experience of Jenny Chu, President of the YCIS Beijing Parent Organisation and her family.
Delivering the Best E-Learning Experience
The abrupt transition to e-learning last semester took us all by surprise, but the adjustment by students and their parents is truly commendable, taking it all in stride. Preparations for the new academic year in September are officially underway and to ensure we kick-start the year on a high note, the academic team with the assistance from teachers are finding innovative ways to continue to offer excellent e-learning to students from K2 – Year 13.
How We Foster Personal Development through Character Education
One of the most important characteristics of our principles at YCIS Beijing is we believe that the core purpose of education is character formation, and it is the most important shared responsibility of the school and home. Within the school, there are designated programmes which are aimed at teaching students about charity, environmental responsibility, and most importantly develop compassion for others while having a strong sense of self. These contribute to our holistic approach to education in preparation for a life post-school.
Five Top Tips for Mental Health this Summer
The summer break was welcomed with open arms by teachers, students and parents alike after several months of eLearning, as a result of the COVID-19 outbreak. Although the majority of students may be experiencing feelings of euphoria during this time, others may be facing mental health challenges. Rachel George, Head of Student Support at YCIS Beijing shares with us factors that can cause stress and ways they can be curbed.
Useful ICT Resources for IBDP Students
Although our YCIS Beijing students like many of their counterparts are enjoying the summer break, we continue to encourage learning to be a constant part of their lives. With the help of Satyendra Arora, YCIS Beijing's Secondary Technology Integrator we compiled a list of resources they can access to improve or learn new ICT related skills.


Currently viewing the tag: "Light Will Consume Us All"
"Anything that comes out on Neurosis' home label, Neurot Recordings, is sure to be drenched in minimalist atmosphere and performed with impeccable skill. After seeing critical success with 2015's debut Unanswered Hymns, as well as this year's split with Fister, Sacramento's CHRCH are set to lay claim to the mantle of heaviest all-caps doom band with the release of sophomore effort Light Will Consume Us All. Being one of the few AMGers who is into long, drawn-out doom extravaganzas, I laid claim to the album immediately, and have cranked it for a month now — because when songs are ten to twenty minutes long, you need a lot of time to dig into them." Missing vowels and busting bowels.


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News Gaming Elon Musk says Cyberpunk 2077 is playable in Tesla Model S which...
Elon Musk says Cyberpunk 2077 is playable in Tesla Model S which have 10 Teraflops of processing power
Vibhanshu Sharma
Elon Musk, the CEO of Tesla and founder and CEO of SpaceX, flaunts that the forthcoming Tesla Model S can compete with Sony's PS5 and Microsoft Xbox Series X as it can run Cyberpunk 2077 on the inside screen. The as of late disclosed new Tesla Model S, the first remodel of the vehicle since it dispatched in 2012, incorporates various extravagant highlights, for example, an upgraded inside and an amazing powertrain.
After uncovering the brand new Plaid Tesla Model S using Twitter, Elon Musk determined that the vehicle's internal screen is fit for running CD Projekt Red's Cyberpunk 2077. The new Model S includes a 17-inch portrait display with a 2200×1300 resolution between the driver and passenger seats, just as a supplementary display for passengers beneath the vehicle's center console.
Extra data from Tesla asserts that the "Tesla Arcade" will empower in-vehicle gaming that rivals current-gen consoles, including up to 10 teraflops of processing force and wireless controller compatibility. The capacity to run Cyberpunk 2077, a very demanding game that was released just a single month prior, shows the power of the Tesla Arcade.
For some comparisons on the teraflop side of this vehicle:
Xbox Series X has 12 teraflops
Tesla Model S has 10 teraflops
PlayStation 5 has 10 teraflops
It can play Cyberpunk
— Elon Musk (@elonmusk) January 28, 2021
With using Cyberpunk to show the new Model S's gaming potential, Elon Musk had another experience with the title toward the end of last year. After the turbulent arrival of Cyberpunk 2077, which was profoundly criticized by players, Musk demonstrated that he was playing the title and encountered a few glitches himself. He started presenting images on his Twitter account, responding to other gamers who experienced troubles and answering posts from the game's development group.
While it's not clear how safe it will be to play video games while operating a vehicle, travelers will have the option to profit from Elon Musk's attention on gaming. If the Tesla Arcade can adequately run Cyberpunk 2077, almost certainly, the vehicle will have the ability to run pretty much any title.
CD Projekt Red's share surges after Elon Musk's tweet
The esthetics of Cyberpunk are incredible btw. The interior design is👌.
However, after Elon Musk expressed his admiration for the game, the Musk effect has already started benefiting the game developers. As on Thursday, CD Projekt's share price went up sharply after this tweet. And reportedly stock was up around 12.6% during afternoon trading.
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The Employee Giving program enables Coast Mountain College staff to have a nominal amount of money deducted from their pay to contribute to student scholarships, awards & bursaries.
For as little as $5 per pay cheque, you can choose the bursary or award that you would like to contribute to. A big thank you to the staff members who have already signed on to the program.
View our FAQs to learn more about how you can contribute to the future success of our students.
To register, submit an CMTN Employee Giving Form [PDF] to Christine Speidel in the Advancement Department at cspeidel@coastmountaincollege.ca.
Funding my five-year education through student loans and part-time work was daunting. I almost quit because I knew how deep in debt I was getting into. I give to the student emergency funds. Most students hit barriers that feel overwhelming. Financial help during an emergency can make a huge impact.
We give to share the opportunity for success. That first helping hand is often the one that makes the biggest difference.
Each pay cheque, the amount you have chosen will be automatically deducted from your paycheck. At the end of the year your tax deductible charitable donation will be on line 46 of your T4, eliminating the extra paperwork and receipts to file.
You can contact Christine Speidel at extension 5383 or cspeidel@coastmountaincollege.ca. There is a form to fill out selecting the amount you would like to donate and where you would like your contribution to go.
You can donate to a student emergency fund, a specific fund of your choice, or the Coast Mountain College Foundation which supports capital projects, programs, bursaries, scholarships, and awards.
Scholarships are awarded on the basis of academic achievement.
Bursaries are awarded based on financial need and satisfactory academic achievement.
Awards are a combination of both.
The awards committee at Coast Mountain College meets regularly to review applications. Recipients are chosen based on criteria established by the donor(s); this could be need, academic achievement or a combination of both.
Yes, the Coast Mountain College Foundation is obligated by law to make this information public.
What tax credits will I receive?


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James Corden Tricks Matt Damon
Matt Damon's latest film, "Jason Bourne," features the return of his iconic super-assassin. To make a good action hero like that, however, requires just as much from stunt men as it does the actor himself. On Monday night, Damon tried to rope James Corden in to being his stunt double, in order to avoid appearing on "The Late Late Show." Corden was excited, taking this as proof that he and Damon look alike, but the job turned out to be a little more painful than expected. For his first scene, Corden got punched in the face. "James looks like he can take a punch," Damon said afterward. "That can't be the first time he's been punched in the face. He's got an extremely punchable face."
by Brendan Lemon | 8/2/16 | Leave a comment |
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Every Minnesotan — regardless of income, race, ethnicity, color, or national origin — has the right to healthy air, sustainable lands, clean water, and a better climate. Unfortunately, too many people, especially low-income communities, communities of color, and Indigenous people, bear the disproportionate impacts of pollution and climate change. The MPCA focuses on developing strategies to reduce pollution and health disparities in communities most at-risk.
Environmental Justice Advisory Group applications open
The MPCA is seeking new members for its environmental justice advisory group. The group will advise the MPCA commissioner on implementing the agency's environmental justice framework, provide feedback on its effectiveness, and ultimately guide systemic change within the agency.
Prioritizing environmental justice
The MPCA is committed to environmental justice, the fair treatment and meaningful involvement of all people, regardless of race, color, national origin, or income, concerning the development, implementation, and enforcement of environmental laws, regulations, and policies. We're committed to making decisions that do not place disproportionate pollution burdens on these communities.
We use environmental justice principles when reviewing and issuing grants to reduce pollution and improve air quality. Environmental justice is part of our decision-making process when writing new or renewal permits for facilities. In some cases we increase air quality monitoring and provide additional scrutiny of emission sources. These principles are the foundation when developing new regulations and conducting enforcement actions.
Early involvement in decision-making
To most effectively reduce pollution risks and impacts on communities, people must have the opportunity to participate in decisions that may affect their environment and health. The public's feedback and concerns can influence the regulatory process and the agency's decisions. We identify and remove barriers to ensure more voices have a role in environmental regulations and decision-making. The MPCA also encourages industries and facilities seeking permits to engage in an open, authentic dialogue with impacted communities.
Better data leads to better results
Many studies demonstrate that low-income neighborhoods and communities of color have higher potential exposures to outdoor air pollutants and have more sources of pollution. In addition, the social, economic, and health inequities that these populations face can make them more vulnerable to the effects of air pollution. For instance, 32% of all communities in the state have air pollution-related risks above health guidelines. However, in low-income communities, the number is 46%. In communities of color, it's 91%.
Seventy-six out of about 2,000 facilities in Minnesota have modeled risks above guidelines. Only about 6% of communities in Minnesota are near one or more of these facilities. However, 14% of communities of color, which include Indigenous peoples, and 9% of low-income communities are located near one or more of these facilities.
Living near air pollution
Your likelihood of living near a facility that emits pollution at a level above health guidelines is higher if you are a person of color, Indigenous, or lower income.
MPCA environmental justice resources
Understanding environmental justice in Minnesota
MPCA Environmental Justice framework (p-gen5-05)
EPA environmental justice resources
EJSCREEN online mapping tool (US EPA)
Environmental justice (US EPA)
MPCA environmental justice advisory group
Ned Brooks
Environmental Justice Coordinator
ned.brooks@state.mn.us


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christianmovies
A Fork in the Road
February 13, 2020 February 16, 2020 | Faith and Family Films
Would you like some fresh ideas and methods to effectively reach your community and fulfill the great commission? That's where I found myself in 2008, and God answered that question for me in an amazing way in my life.
I was born and raised in Hollywood. Not the Hollywood of Southern California, but the Hollywood District in Portland Oregon. In 1983 I became a follower of Christ and my desire was to fulfill the great commission in some form or fashion. In 1993 I graduated from Multnomah University and I was ready to embark on the journey to make a difference in the world. Over the years, I have been able to fulfill that desire with many mission trips, two church plants and numerous years as a pastor to youth and children. I have definitely had numerous mountain top experiences and a few low points of desperation along the way. But all in all the first few chapters have been exciting and fulfilling in so many different ways.
The next few chapters were about to be written in my story. In 2008 the story of my life was about to make a major change in the midst of uncertainty. I was facing a fork in the road and did not know what I was going to do and how I would continue to fulfill the great commission. Well, an opportunity was presented to me. But not in Portland or the Hollywood District this time, instead the Hollywood in Southern California.
The opportunity was to help spread the gospel through the medium of film and over the last twelve years I have had the privilege of working on the marketing teams for over 55 feature films. This opportunity has allowed me to continue to fulfill the great commission. With stories of lives challenged and changed because of films like Warroom, October Baby, Hacksaw Ridge, Woodlawn, Soul Surfer, The Star, Paul The Apostle of Christ, Breakthrough and I Can Only Imagine. The stories have been nothing short of inspiring and they reminds me that God can use anyone and anything to fulfill the great commission. I am so thankful for the door that the Lord has opened for me to be used in the "other Hollywood".
Currently I am working on two incredible films that deliver a powerful message that will encourage the church and will provide the opportunity to laugh and learn to love through the pain of life. The first film is "I Still Believe" and the second is a family comedy called "Selfie Dad".
I Still Believe opens in theaters nationwide March 13th and is an inspiring love story for the ages. It's based on the real-life story of chart-topping singer Jeremy Camp and is a powerful reminder that in the midst of life's storms, true hope can be found. The film stars Gary Sinise as Jeremy Camp's father and he does a fabulous job bringing insight to the story.
On June 12th, 2020 Selfie Dad hits theaters one week before Fathers Day. Some films have an inspiring faith-based message and others are fall-out-of-your-chair funny, but I don't think there has ever been a faith film that was both? I believe Selfie Dad is that movie. Watch for the launch of the official Selfie Dad trailer on Tuesday February 25th, 2020.
Both I Still Believe and Selfie Dad are films that will inspire the church and cause people to reflect on their personal journeys. I hope and pray these films will play a part in stirring renewal and personal revival throughout America.
My journey continues and allows me to fulfill the call the Lord put on my life many years ago 'to go into all the world and preach the gospel' with some fresh new ideas using the medium of film to impact culture with the good news.
If you are interested in learning more about these two films and how you can utilize them to impact your community, please email me or give me a call.
David Almgren
dave@faithandfamilyflms.info
I Still Believe movie website
https://istillbelievemovie.com
https://istillbelievemovie.com/share-tools
Selfie Dad the Movie Website
The Selfie Dad official trailer is coming Tuesday February 25th, 2020.
https://selfiedadmovie.com