text:
Report: Most States Have Poor Safeguards Against the Revolving Door
By Angie Schmitt
States do a poor job safeguarding against corruption, according to a recent report from the Center for Public Integrity. The list above ranks state ethical protections in descending order. The green states received "B" grades; yellow ones got "C"s; orange ones earned a "D"s and the red ones failed. Image: ##http://www.stateintegrity.org/your_state##Center for Public Integrity##
Last week we looked at three state DOTs which are currently led by former lobbyists for the asphalt or energy industries. The "Revolving Door" series highlighted how billions in federal funding for transportation get funneled, with no oversight, to states where money and politics corrupt policy and lead to shocking amounts of waste.
While it's outrageous that a state DOT chief can flit back and forth between lobbying gigs and the public sector, or dole out enormous contracts designed to benefit the governor's political benefactors, such antics aren't limited to the three states we profiled. For a good survey of the lax ethics rules that prevail in most American statehouses (affecting not just transportation but all aspects of state policy), check out the Center for Public Integrity's State Integrity Investigation.
CPI's recent analysis found that loose state ethics rules and oversight are the norm, not the exception, in state capitals around the country. The group graded all 50 states, and not a single one scored an A. Only five states managed Bs. The rest were all mediocre-to-abysmal.
The three states Streetsblog examined — Ohio, Texas, and Oklahoma — received Ds for overall ethics oversight and transparency.
The report found that, across the country, state-level ethics protections are weak, and where they do exist, they often lack teeth.
Tennessee, for example, started a state ethics commission six years ago, but has yet to issue a single citation.
Notably, in CPI's investigation, Ohio, Texas and Oklahoma all rated below 50 percent — a failing grade — on "regulating conflicts of interest by the executive branch" — the rules and oversight that would apply to state DOT directors.
The agency responsible for ethics oversight in Austin, for example, is basically set up to fail.
"The Texas Ethics Commission is comprised of appointees by the governor and legislature, which not only presents an inherent conflict but often leads to gridlock," CPI's Caitlin Ginley said. "Commissioners are typically split along party lines, but in order to pursue an investigation, at least six of the eight commissioners must agree."
As a result their analysis, CPI reports, Maine is currently considering legislation that would establish "cooling off periods" preventing state officials from working for the industry they regulated immediately after leaving the public sector — an attempt to halt the "revolving door."
Meanwhile, the next time you hear an elected official call investments in transit, biking, or walking a waste of money, keep in mind how road builders can exploit weak ethics rules to make sure billions get spent on highways to nowhere.
Filed Under: Ohio, Oklahoma, Texas, The Revolving Door
The Revolving Door: TxDOT's Phil Wilson, "Revolver in Chief"
By Angie Schmitt | Feb 1, 2013
This is the final installment in our three-part "Revolving Door" series about how cronyism in state DOTs leads to wasteful highway building. The first part profiled Ohio DOT chief Jerry Wray and the second part looked at Oklahoma DOT boss Gary Ridley. Both Wray and Ridley left the DOTs to work as asphalt industry lobbyists, only to return […]
The State DOT Revolving Door: Meet Jerry Wray, Ohio's "Asphalt Sheriff"
By Angie Schmitt | Jan 29, 2013
One of the top goals of the national transportation reform movement is to get state DOTs to spend their money more wisely. The feds distribute tens of billions of dollars to state DOTs each year with very few strings attached. But for every state like Massachusetts or Tennessee that's decided to shift toward building walkable […]
The Revolving Door: Oklahoma's Gary Ridley – Asphalt Lobbyist, DOT Chief
This is the second installment in our three-part "Revolving Door" series about how cronyism in state DOTs leads to wasteful highway building. The first part profiled Ohio DOT chief Jerry Wray, who has switched back and forth between working directly for the asphalt industry and shoveling money to the asphalt industry as a public official. […]
NHTSA Chief David Strickland Gets Caught in the Revolving Door
By Tanya Snyder | Jan 10, 2014
When David Strickland announced last month that he was stepping down as the head of the National Highway Traffic Safety Administration, he didn't give any clues about where he might be going. The news came out this week: The nation's top auto regulator is going to be a lobbyist at a law firm that deals […]
Puppies and Peanut Butter: Brookings on State Transpo Mistakes
By Tanya Snyder | Feb 23, 2011
As transportation advocates adapt their messaging to a new, more conservative Congress, the language of fiscal conservatism has become the mother tongue of the movement. Smart Growth America and the Bipartisan Policy Center have recently used the fiscal responsibility argument to urge policymakers to invest more strategically, especially as infrastructure budgets shrink. Now the Brookings […]
Brookings: Revive State Infrastructure Banks to Stretch Transpo Dollars
By Angie Schmitt | Sep 14, 2012
In these days of stagnant gas taxes, state and local governments are scrambling for new ways to finance infrastructure. Rahm Emanuel has his $7 billion Chicago Infrastructure Trust, and Antonio Villaraigosa has his America Fast Forward. Even John Kasich in Ohio is trying to sell advertising at rest stops to shore up ODOT. In a […]


What is The Purpose of Plasterboard in Building Construction?
When searching for the ideal wall panels, there will be a variety of aspects you would want to look for. With different options like plywood, hardboard, fiberwood and plasterboard, there is a large range of properties you can consider for your construction job.
Plasterboard is one of the most widely used material in construction jobs, be it residential or commercial. Here, let's talk about the benefits and purpose of plasterboard in building construction.
Flexibility – Compared to other wall types, plasterboard can be installed as an interior wall in your building in a much lesser span than that of other panel options. A conventional plaster application can take a week or more, whereas when the same job is done using plasterboard or drywall, it can be done within a day or two. Gypsum panels can fit in a variety of office environments, ranging from warehouses to companies. Our Konnstruct Plasterers in Melbourne will complete your job within the suggested time-frame along with an outstanding result.
Fire Resistant – Many hazardous materials are used on a daily basis for different work processes. But, when you design a building, it is extremely important to take this combustibility factor into consideration. Plasterboard is extremely resistant to fire. Because of its non-combustible core, it retards the spread of heat and fire. In fact, even after complete calcination, plasterboard continues to serve as a heat-insulating barrier. With low smoke density and low flame spread index, plasterboard continues to effectively protect your building from fire.
Sound Dampening – Restraining the transfer of unwanted sound to neighbouring areas is a key factor to be considered when designing a building, especially a commercial one. When a company constructs its conference room right besides a manufacturing amenity, you better ensure that the wall panels will absorb all the unwanted noise coming from outside. This is where plasterboard or gypsum board comes into the picture. With a polystyrene core, gypsum does a great job of minimising sound transmission by its own.
Cost – To conclude, plasterboard is a very convenient option for almost any wall application for building construction. Gypsum has been used commonly in construction since centuries. All you need is mineral gypsum, a few additives and water in order to make plasterboard. Since these are readily available and the process is easy, the overall price of the product is extremely less. With its high durability, maintenance costs are very low, making upkeep a breeze.
At Konnstruct, we use plasterboard panels on a majority of our internal wall panels. Although we wouldn't suggest that plasterboard is the perfect material for every wall, it is our go-to material for building construction that solves your space needs at a low price. Get in touch with our team for all your Plastering in Melbourne needs today! Call us now at 1300 743 734.


text:
ASH Clinical News
ASH News Daily
ASH-SAP
Blood Advances
The Hematologist
Blood Chinese Edition
Blood Japanese Edition
Blood Italian Edition
Blood Latin America Edition
Blood Spanish Edition
ASH Home
ASH Store
search filter All ContentAll JournalsBlood
2020 Late Breaking
All Meeting Abstracts
Author Center
Why Submit to Blood?
About Blood
Editorial Board and Staff
Blood Classifieds
641. CLL - Biology and Pathophysiology, excluding Therapy: Poster III| November 18, 2011
17p Deletion Is the Most Frequent Abnormality Acquired During Clonal Evolution in Chronic Lymphocytic Leukemia (CLL): 429 Cases Analyzed by Interphase FISH and Chromosome Banding Analysis,
Claudia Haferlach, MD,
Claudia Haferlach, MD
MLL Munich Leukemia Laboratory, Munich, Germany
Melanie Zenger,
Melanie Zenger *
Susanne Schnittger, PhD,
Susanne Schnittger, PhD
Wolfgang Kern, MD,
Wolfgang Kern, MD
Torsten Haferlach, MD
Blood (2011) 118 (21): 3870.
https://doi.org/10.1182/blood.V118.21.3870.3870
Claudia Haferlach, Melanie Zenger, Susanne Schnittger, Wolfgang Kern, Torsten Haferlach; 17p Deletion Is the Most Frequent Abnormality Acquired During Clonal Evolution in Chronic Lymphocytic Leukemia (CLL): 429 Cases Analyzed by Interphase FISH and Chromosome Banding Analysis,. Blood 2011; 118 (21): 3870. doi: https://doi.org/10.1182/blood.V118.21.3870.3870
Abstract 3870
Background and Aim: CLL is a chronic disease with heterogeneous clinical course. While a subset of patients requires early treatment others are followed without treatment for many years. Cytogenetic aberrations have major impact on the prognosis. The aim of this study was to evaluate 1) the frequency of gain of additional chromosome aberrations during the course of the disease (clonal evolution,CE) 2) the pattern of genetic abnormalities acquired during the CE 3) the association between genetic parameters at diagnosis and CE and 4) the impact of CE on clinical outcome. An additional aim was to compare monitoring by interphase FISH (IP-FISH) or chromosome banding analysis (CBA). Patients and Methods: Two different cohorts were evaluated: A) 363 CLL patients who were analyzed during the course of their disease at least at 2 time points by IP-FISH. In this cohort only patients were enrolled who were analyzed at each time point with the complete FISH panel using probes for 13q14 (D13S25, D13S319), 11q22 (ATM), 17p (TP53), 6q21/6q23, chromosome 12 centromer and IGH -CCND1. B) 245 CLL patients who were evaluated by CBA at least at 2 time points. 179 cases were included in both cohorts. Results: In cohort A 954 FISH analyses were performed in 363 cases (mean: 2.6, range: 2–14). The median time between the first and the last evaluation was 21.1 months (range 1.0–68.9 months). Overall, in 42 of 363 patients (11.6%) clonal evolution was observed, 9.3% of untreated and 16.8% of treated patients showed clonal evolution (p=0.05). The most frequently acquired abnormality was a 17p deletion detected in 12/42 (28.6%) cases, followed by deletion of 13q14 and 11q22 (9 cases each, 21.5%). In 6/131 (4.6%) cases with heterozygous 13q14 deletion at first analysis a homozygous 13q14 deletion was observed during follow up. In 290 of 363 the IGHV mutation status was available. An unmutated IGHV status tended to be associated with clonal evolution, 26/35 (74.3%) cases with and 147/255 (57.6%) patients without clonal evolution showed an unmutated IGHV status (p=0.067). No association between any specific abnormality detected by FISH and clonal evolution was observed. The median time between first FISH analysis and the first detection of clonal evolution was 25 months (range 2–65 months). In cohort B 618 CBA were performed in 245 cases (mean: 2.5, range: 2–8). The median time between the first and the last evaluation was 18.8 months (range 1.0–68.9 months). In 73 patients (30.0%) clonal evolution was observed. The most frequently acquired abnormality was loss of 17p detected in 26 cases, followed by deletion of 13q (n=21), and 11q (n=8). Other recurrent aberrations occurring during CE were gains of 8q (n=14), 13q (n=11), 17q (n=8), 1q (n=7), 3q (n=6), 16q (n=6), 4q (n=5), 1p (n=5), 9q (n=4), 15q (n=4), losses of 8p (n=10), 9q (n=8), 8q (n=7), 9p (n=7), 6q (n=7), 1q (n=6), 6p (n=5), 1p (n=5), 10q (n=4), 7q (n=3) and 14q32-rearrangement (n=6) with different partners (2p11, 4p16, 10p11, 2x 8q24, 19q13). In 202 of 245 patients the IGHV mutation status was available. An unmutated IGHV status was significantly more frequent in cases with as compared to patients without CE (44/62 (71.0%) vs 75/140 (53.6%), p=0.021). The median time between first CBA and the first detection of clonal evolution was 21 months (range 1–65 months). Clonal evolution was observed in 7/48 (14.6%) patients with normal karyotype, in 48/159 (30.2%) cases with non-complex aberrant karyotype and in 18/38 (47.4%) patients with complex karyotype (≥ 3 abnormalities) (p=0.04 for normal vs non-complex aberrant and p=0.056 for non-complex aberrant vs complex). For 135 of 245 cases clinical data with respect to treatment was available (45 cases with and 90 without CE). 33/45 (73%) patients with and 52/90 (57.8%) without clonal evolution had received treatment. A tendency towards a shorter overall survival was observed in patients with as compared to patients without CE detected by CBA (alive at 10 yrs 75.4% vs 93.5%). Conclusions: 1. Chromosome banding analysis detects clonal evolution more frequently than IP-FISH (30.0% vs 11.6%). 2. Clonal evolution occurs more frequently in patients with an unmutated IGHV status and an aberrant karyotype with the highest frequency in patients with complex karyotype. 3. Sequential analyses by FISH and CBA seem reasonable as especially 17p abnormalities occur frequently during the course of the disease, which impacts on treatment decisions.
Haferlach:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Zenger:MLL Munich Leukemia Laboratory: Employment. Schnittger:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Kern:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Haferlach:MLL Munich Leukemia Laboratory: Employment, Equity Ownership.
chromosome 17p deletion, chromosome banding, chronic b-cell leukemias, chronic lymphocytic leukemia, interphase, karyotype determination procedure, leukemia, chronic disease, cyclin d1, did not receive therapy or drug
Asterisk with author names denotes non-ASH members.
© 2011 by The American Society of Hematology
Close comment form modal
"I agree to the terms and conditions." You must accept the terms and conditions.
You have entered an invalid code
Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email.
Sign In or Create an Account Close Modal
Submit to Blood
Advertising in Blood
American Society of Hematology
2021 L Street NW, Suite 900
TEL +1 202-776-0544
ASH Publications
Hematology, ASH Education Program
Copyright ©2020 by American Society of Hematology

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: How to add _.debounce to Foundation range slider? I have a Foundation range slider on my site. The intended function is that when the slider is moved, it submits an Ajax query and updates a list of search results. This is my JQuery for when the slider changes:
$('[data-slider]').on('change.fndtn.slider', function(){
    $('#location-ajax-filter').trigger('change');
});

This works perfectly. However, I've noticed that it fires a zillion times. On page size change, on page load, on slight movement of the slider, etc. This is something I would like to have better control over. It seems to me that the Foundation range slider is lacking one fundamental thing - a stop event like the JQueryUI slider has. I don't want the overhead of JQueryUI, so I don't want to use it.
Since I already have _underscore.js as part of my build, I figured why not use the _.debounce to control the firing. The thing I need help with is how to rewrite the code above.
I've tried this, but it doesn't seem to work - I think I'm calling the debounce function in the wrong place?
$('[data-slider]').on('change.fndtn.slider', function(){
    _.debounce($('#location-ajax-filter').trigger('change'), 3000);
});

Also, is there a way I can extend this to address page size changes and keep it from firing on page load?
Any help would be greatly appreciated!
UPDATE
I think I may have sorted out how to use the debounce function, however, I still have not resolved how to keep the data slider from firing on page load and page resize. This is how I partially resolved the issue:
$('[data-slider]').on('change.fndtn.slider', _.debounce(function(){
   $('#location-ajax-filter').trigger('change');
}, 1000));

Still need help if anyone knows the answer for the page load and size.

redpajama_set_name: RedPajamaStackExchange


Netter's Neurology provides the best of an atlas, an anthology of clinical cases, & an important basic introduction to requisite information needed to diagnose & initiate treatment of various neurologic and neuromuscular disorders. Case vignettes from the Lahey Clinic set the stage for discussion of the basics of specific neurologic disorders, including history, epidemiology, clinical presentation, differential diagnosis, testing modalities, therapy, & prognosis. To help readers more easily and clearly conceptualize this complicated body system, more than 350 classic Netter and Netter-style illustrations are included and supplemented by modern neuroimaging, or photomicrography, further defining the anatomy of the specific areas of dysfunction.


It's possible for one's investments to be allocated among beneficiaries unfairly without a clear property plan. It really is normal for conflicting things on the house to arise after one's death.
To effectively manage such things, one must retain the services of the services of a skilled lawyer. The legal professional perceives to it that the property is handled relating to the hopes of the deceased. You may also know about an estate planning lawyer via http://www.voyantlegal.com/ogden-elder-law-attorney.html.
This means that the estates are allocated to beneficiaries quickly and reasonably. A good legal professional can also assist in choosing somebody who is designed for the estate in the event the dog owner dies.
An excellent plan minimizes fees that are owed by people's estates giving the allowed maximum to various beneficiaries. If one possesses a company empire, they need to ensure that the business operates uninterrupted by describing a good plan of succession and syndication of revenues.
In the case of death, regulations stipulate plainly how one's estates can be allocated. An experienced law firm can help in safeguarding the house. The lawyer means that the assets aren't susceptible to this long and expensive treatment. They also lessen tax responsibility which estates suffer when the owner dies.


Serving St. Louis since 1991, St. Louis Lock and Key is the locksmith to call in all situations. Whether you need emergency service on a motorcycle in the middle of the night or you'd just like to re-key your entire fleet, St. Louis Lock & Key can accommodate you with skill and speed. We can provide a wide range of services, from high-tech solutions like automotive chip keys to solving the simplest issue imaginable: a lost key.
St. Louis Lock & Key has been serving St. Louis since 1991 and is an AAA vendor. We opened in 1991 with the hopes of being the best. We've achieved our goal and are now proudly serving many repeat customers.


text:
Final Diagnosis -- Waldenstrom's Macroglobulinemia
FINAL DIAGNOSIS:
WALDENSTROM'S MACROGLOBULINEMIA WITH:
ADVANCED AMYLOIDOSIS (lambda light chain type) INVOLVING GLOMERULI (nodular lesions) AND RENAL BLOOD VESSELS, WITH MODERATE TO FOCALLY MARKED TUBULOINTERSTITIAL CHRONICITY CHANGES.
ATYPICAL, MONOCLONAL LYMPHOPLASMACYTIC INTERSTITIAL INFILTRATE (CD20+, IgM+, lambda light chain restricted) WITH ADMIXED REACTIVE T-LYMPHOCYTES (CD3+); CONSISTENT WITH RENAL INTERSTITIAL INVOLVEMENT BY PATIENT'S LYMPHOPLASMACYTIC LYMPHOMA.
Waldenstrom's macroglobulinemia, representing approximately 2% of hematologic malignancies (2), is less common than multiple myeloma, and must be differentiated on predominantly clinical grounds from other entities presenting with monoclonal spikes of IgM. These conditions include the monoclonal gammopathy of undetermined significance (MGUS), various B-cell lymphomas, chronic lymphocytic leukemia, IgM myeloma, essential macroglobulinemia, and plasmacytoma (1). The condition is diagnosed in approximately 1,500 individuals annually in the U.S., and is usually not detected until either the paraprotein level exceeds 3.0 g/dL (1,2), or until the blood viscosity is at least four times that of normal serum (2). As demonstrated by this case, the common presentation occurs in elderly males showing signs of organ involvement and bone marrow infiltration. The most common finding in patients (not appreciated in this current case) is the hyperviscosity syndrome, seen in approximately 15% of cases (2). The clinical presentation includes fatigue, dizziness, blurred vision, and easy bleeding of mucous membranes (2). In addition, cryoglobulinemia, peripheral neuropathy, hemorrhagic diatheses, and diffuse systemic amyloidosis have also been described (1), and usually occur in patients without lymphoma (2). The current case demonstrated acute renal involvement with the infiltrating lymphoma and glomerular-based changes which is of significance since severe proteinuria in the nephrotic range, and renal insufficiency are usually an infrequent finding in Waldenstrom's as compared to multiple myeloma (1). The difference in clinical presentation is felt to be secondary to the lower frequency of both Bence-Jones proteinuria and hypercalcemia in Waldenstrom's macroglobulinemia (1,2).
The pathologic renal findings in Waldenstrom's macroglobulinemia by light microscopy and other methods are described as four potential patterns of involvement, with simultaneous overlap of each pattern possible in any given patient. The first is apparent widespread capillary loop "thrombosis" by acellular hyaline material that is PAS positive (as seen in this case). Of significance is the near total lack of a cellular response to the amorphous material giving the appearance of "pseudothrombi," and which is also seen to expand the mesangium. These deposits directly correspond to the amyloidotic IgM material, with a glomerular and vascular distribution (as illustrated in this patient's renal biopsy). Interestingly, the "pseudothrombi" result from the amyloid / IgM deposits displacing the endothelial cells from a subendothelial / mesangial location to occlude the capillary lumen. True thrombi can be ruled out on light microscopy and immunofluorescence, as fibrin stains will be negative in the glomerular capillary loops (1). The second presentation on renal biopsy consists of a proliferative glomerulonephritis consistent with cryoglobulinemia and hypocomplementemia (1). This condition can also lead to massive true capillary loop thrombosis with a cellular proliferative glomerulonephritis and complement activation (not seen in the current case). Amyloidosis, the third possible presentation, is seen in less than 5% of Waldenstrom's patients, and represents the most frequent cause of nephrotic range proteinuria in affected patients (1). This finding is illustrated to a degree by this patient as shown by the immunostaining results and electron microscopic findings of organized fibrils. These changes overlap with the light microscopic features presenting as "pseudothrombi." The fourth, and considered the most common presentation, is that of diffuse renal parenchymal infiltration by the actual lymphoproliferative cells causing the Waldenstrom's macroglobulinemia (illustrated in the current case) (1). The atypical lymphocytes are morphologically and phenotypically identical to the cells usually detected in the bone marrow, in 90% of cases (2), or elsewhere including lymph nodes, the lungs, the gastrointestinal tract, or the skin (2). Of importance for the renal biopsy, these infiltrates have been described in all anatomic locations of the kidney, including the cortex, medulla, and hilar / peripelvic fat. The infiltrates may also surround and involve the ureter (1). Within the kidney, the lymphoid infiltrates usually circumscribe and compress the tubules with or without tubular damage. In cases with significant tubular damage, the infiltrates are thought to contribute directly to the acute renal insufficiency (1).
To illustrate the variability of clinico-pathologic presentations, the reader is referred to a case report of a 53 year-old man with Waldenstrom's macroglobulinemia and acute renal failure (3). The authors describe a monoclonal IgM kappa-restricted paraprotein spike detected in the gamma range on electrophoresis, normal serum viscosity, and a less severe degree of renal failure showing a creatinine clearance of 78 mL/minute. A bone marrow biopsy also revealed an immunocytoma, but the renal biopsy showed only a minimal lymphocytic infiltrate without atypia. Similar glomerular changes were noted as in the current case with a mild degree of tubular atrophy; however, Congo Red stains were negative for amyloid. The patient underwent an extensive chemotherapy regimen including cyclophosphamide, vincristine, and prednisone with improvement in renal function and clearing of the kappa light chains by urine immunoelectrophoresis. The serum IgM paraprotein, although decreased, was still present after 21 months of chemotherapy; and the patient still had residual hematuria suggestive of persistent glomerular damage. These results, however, are consistent with the impression that depending on the severity of the proteinuria, the renal insufficiency can be mild and reversible with treatment (2).
Another case report describes a 66 year-old female with very similar clinical findings as described in the current case, with mild persistent edema of the feet and lower extremities for four months duration as the only significant finding on exam (4). As in our case, this patient showed a monoclonal IgM lambda-restricted paraprotein, and proteinuria also in the nephrotic range. The renal biopsy showed subepithelial and subendothelial deposits of Congo Red positive fibrillary material consistent with glomerular amyloidosis, and IgM deposition in both the mesangium and along the glomerular capillary membrane. The reader is referred to the excellent discussion of the clinical differential diagnoses provided in this case report (4). Information on prognostic factors is limited due most likely to the relatively infrequency of Waldenstrom's; however, age greater than 60 years, male gender, hemoglobin less than 10 g/dL, and neutropenia, are associated with a shorter survival (1,2).
Current treatment options include those discussed above (3), the use of chlorambucil on daily low-dose and intermittent high-dose schedules (1,2,4), interferon-alpha (2), and plasmapheresis to decrease the level of circulating IgM paraprotein since 80% of the IgM exists in a circulating form (1,2). In cases with hyperviscosity syndrome, chemotherapy is recommended to aid in rapidly decreasing the paraprotein level, and to target and control the underlying lymphoproliferative disorder. The therapeutic regimens were adapted from those used for chronic lymphocytic leukemia, and have shown a median survival of 5 years, with 20% of patients dying of unrelated causes (2). A reported 10% of patients will achieve complete clinical remission with clearance of the IgM paraprotein on studied by electrophoresis and immunofixation, with median survival regarded as 11 years (2). Alternative chemotherapeutic agents including fludarabine and 2-chlorodeoxyadenosine have also shown some promise in the treatment of this disease.
Schwartz, MM. Chapter 31: The Dysproteinemias and Amyloidosis; Heptinstall's Pathology of the Kidney; 5th Edition, Volume 2; Lippincott-Raven, Philadelphia, PA; pp. 1334-1337.
Dimopoulos, MA, and Alexanian, R. Waldenstrom's Macroglobulinemia. Blood, 83 (6); March 15, 1994: 1452-1459.
Veltman, GAM, et al. Renal Disease is Waldenstrom's Macroglobulinemia. Nephrol Dial Transplant, 12; 1997: 1256-1259.
Soetekouw, R, et al. A 66-year-old Woman with Nephrotic Syndrome and an IgM Monoclonal Gammopathy. Ann Hematol, 76; 1998: 227-230.
Contributed by Douglas R. Johnson, MD


Over the past few days I have had a number of long discussions with other credit unions and credit union suppliers about where our system is headed and what the challenges are.
First it seems important to realize that though we all call ourselves credit unions there is a difference behind the scenes. There are the large credit unions and the small credit unions. For the most part the size of the credit union is a differentiator in more ways than we might think.
Independence. This would mean that the credit union values and maintains its own sense of who it is and how it fits into the cooperative system. It means that by being independent it is accountable and responsible for its own decisions. I think credit unions have become lazy in not attempting to understand vital areas of their operation, specifically technology. They rely on the advice of others and haven't taken the time to realize the extent and future challenges that may be in store for them when they make decisions about a banking system or switch provider without sound evidence. Knowledge starts first from admitting ones ignorance. The beauty of the credit union system is that most credit unions are willing to share any information if one begins at that humble position.
Innovation. This means keeping a key strategy that smallness brings, the ability to turn on a dime when it comes to creating and producing a product or service. When you see innovation as a strategic weapon you will be amazed at the possibilities available. You turn from the depressing "we can't do that" to the positive "why can't we do that". It is very powerful when your energies are used in developing things your member wants instead of cloning what others already have.
Integrity. No credit union will last when it neglects this aspect of who they are. You cannot operate in a healthy fashion with your members or in the marketplace without this. The trust that you have will disappear when you forsake a culture established on having integrity. Sometimes it can be painful but whatever the loss, the gain is usually magnified by remaining true to who you are.
There are large credit unions that also have these attributes in their culture but because of their size they may not have them woven into their everyday fabric as much as a smaller credit union. Sometimes size diminishes the possibility of such. Small credit unions have less of an internal political life and because of this tend to approach problems differently within the credit union system. You can solve problems easily when the operational issues are solved. It becomes very difficult to finalize anything when politics become so dominant.
Great article Gene. Keep rocking and proving that small is still doable!


Football coaches seek specific fits for Bethel athletics.
A blizzard covers the quaint town of Yuma, Colorado. A fresh coat of snow blankets the road. Glaring ice an ever-present threat as the howling wind pushes against the side of Scott Kirchoff's car like an offensive line doing sled drills. A strong gust pushes the white Ford Focus towards the shoulder, and Kirchoff yanks the wheel back to avoid the steep ditch that lies in waiting.
Kirchoff, Bethel University's former assistant football coach, thinks that he is on the way to Woody's restaurant to meet the next starting quarterback for the Bethel Royals, because that's who he was told he was meeting. However, waiting for him is a 300 lb. offensive lineman named John Chouinard and his mother, Margaret.
As a recruiter for the Bethel football team, Kirchoff scans the small diner looking for what he thinks a quarterback might look like. Across the room is the only high school boy in the place. Kirchoff walks up tentatively and asks if the young man is John Chouinard, wondering as he approaches how in the world this man can do a seven-step drop back without tripping over his own feet.
John responded, "Offensive lineman coach, why do you ask?" Kirchoff let out a sigh of relief and proceeded with his recruitment pitch.
The world of Division III Christian College football recruiting is not one of glitz and glamour. It often involves weird hours, long road trips, and a lot of lukewarm hotdogs at high school football games all across the country – even during the season. When it comes to recruiting for Bethel, coaches are after specific types of players.
"We want players who love the Lord, and love football," Greg Peterson, an offensive coordinator and recruiter, said. "We don't recruit everyone, because everyone is not a fit for Bethel. We want kids who will thrive academically, and kids who can play athletically." Peterson also said whenever a Bethel recruiter sits down with a kid, they are always very up front about what Bethel is about and what they expect from them as part of the Royals family.
Funds are needed in order for the recruiters and coaches to do their job and bring in players to the program. According to Bob Bjorklund, Bethel's athletic director, money used for recruitment comes from the football team's budget which stems from the athletic department's overall budget. No specific numbers were given.
The Royal's coaching staff knows that recruitment is only the first step in developing a Championship level program. The improvements that develop daily in the players on the practice field and in film sessions gives coaches hope to turn the Bethel football program into a perennial powerhouse.


text:
Tripti Home
Tripti Joshi (Editor)
I Live my life to the Fullest!!! coz you know you only get one !!!
Birth name Orlando Colon
Billed weight 217 lb (98 kg)
Billed height 6 ft 0 in (1.83 m)
Name Orlando Colon
Billed from San Juan
Debut 2005
Born March 24, 1982 (age 33)San Juan, Puerto Rico, United States (1982-03-24)
Ring name(s) Dos EquisDynamicoEpicoFernandoFire BlazeOrlando ColonTito ColonTito Nieves
Trained by Carlos Colon Sr., Dan Severn
Orlando Tito Colón (born March 24, 1982) is a Puerto Rican professional wrestler. He is currently signed to WWE, where he performs on the SmackDown brand under the ring name Epico Colón. He is one-half of the tag team The Colóns with his real-life cousin, Primo Colón.
Early career (2004–2006)
World Wrestling Council (2006–2011)
Pro Wrestling Zero1 (2009)
Florida Championship Wrestling (2010–2011)
Teaming with Primo (2011–present)
In wrestling
Championships and accomplishments
Colón attended Western Michigan University, graduating with a bachelor's degree in accounting. While attending, he played baseball for the Western Michigan Broncos.
Colon began his training at Dan "The Beast" Severn's, Michigan Sports Camps and competing in Price of Glory Wrestling (Coldwater, MI) in 2004. Colón began wrestling in the independent circuit of the United States, performing in Hybrid Pro Wrestling, a promotion based in Schoolcraft, Michigan. He was given a villainous persona, which noted his lineage as a member of the Colón family, as well as a gimmick of "winning by any means necessary", emphasizing his heel character. It was in this promotion that he first used his finisher move, a swinging half nelson with leg capture dubbed "Orlando's Magic". Concurrently, he worked three dates for Price Of Glory Wrestling and eight for Independent Wrestling Association Mid-South. Colón participated in the tournament to crown the first Hybrid Pro Wrestling Champion. In the first round, he was booked against CJ Otis, being eliminated after losing the contest by pinfall due to interference. Subsequently, Colón created a tag team with independent wrestler Jack Thriller, from Honolulu, Hawaii. The team began a feud with Jayson Quick and Josh Abercrombie, which was scheduled to conclude at a special event titled Phase: One. However, Colón was included in an angle where he provoked Quick, engaging in a public fight. As part of the storyline, Colón and Quick were banned from participating at Phase: One by the HPW Championship Committee. He was said to be cleared to return, but as part of the angle Colón refused to wrestle in the promotion until the company compensated him. This storyline was used to explain Colón's departure from the company due to moving back to Puerto Rico.
In 2006, Colón joined the World Wrestling Council, a promotion owned by his uncle, Carlos Colón, Sr.. He debuted as the mystery opponent in a stipulation match that promoted the debut of "another member of the Colón family". Shortly afterwards, he made his return to the company under a masked gimmick named "Fireblaze". Under this ring name he won his first title in the promotion, the WWC Puerto Rico Heavyweight Championship, being booked to defeat "El Bronco" Ramón Álvarez. During the following six months, Colón dropped and recovered the title twice, before dropping it a final time on March 24, 2007. He continued using the pseudonism and was included in a feud with Bronco. The storyline concluded at Aniversario 2007, where he dropped a retirement & mask vs. retirement match between them, revealing his identity. During the first half of 2008, WWC organized a tournament for the vacant WWC Universal Heavyweight Championship. The event presented a purported points system, in which Colón gained an early and decisive lead. Concurrent to this tournament, he entered in a feud with El Condor, a masked character played by Ray González. After defeating El Condor one week before Honor vs. Traicion, a stipulation match was scheduled for that event, in which El Condor would receive the same amount of points held by Colón. At the event, Colón was booked to lose the match. The angle between both wrestlers continued, before serving as a transition to a feud between an unmasked Gonzalez and the other members of the Colón family. Subsequently, Colón continued his involvement in the tournament, entering a feud with the second seed, Noriega. The finals were held at Aniversario 2008, with Noriega defeating Colón to win the Universal Heavyweight Championship. He continued performing in contests against both González and Noriega, who assaulted him in a backstage segment. After Noriega abandoned the company, Colón moved on to feud with Gonzalez, exchanging victories with him. On September 6, 2008, Colón defeated Steve Corino. Following this, Colón suffered an injury that kept him out of being booked in matches, while participating in backstage segments.
In December 2009, Colón appeared in a spot where he signed a legal documment that allowed El Bronco to return to the promotion, in order to fight against González, who had now received a face persona. At Euphoria 2009, Colón returned as a masked heel wrestler, subsequently introduced as La Pesadilla, attacking González. Meanwhile, he also continued performing backstage as a face under his former character. The angle continued, with La Pesadilla performing multiple attacks and interventions against Gonzalez, who offered a ransom of $5,000 for the wrestler's identity and contracted a private investigator. As a result of this, two more masked wrestlers began serving as bodyguards. La Pesadilla's in-ring debut took place at Camino a la Gloria 2009, where he defeated Shane Sewell. On that same night, Colón wrestled under his face character, performing against Bronco. The match was won by Bronco, after González entered dressed as La Pesadilla and interrupted the action. After the contest, González gave Colón the mask, revealing him as the wrestler responsible for the attacks against him. The feud peaked at the promotion's top annual event, Aniversario 2009. Here Colón was booked to lose against González in a contest that featured Félix Trinidad as the guest referee, dropping the mask and adopting the pseudonym Orlando "La Pesadilla" Colón. After this event, Colón formed a heel stable with Hiram Tua Mulero, subsequently including Eric Pérez. As the leader, he continued feuds with González and the company's face faction. While leading the group, Colón won his fifth Puerto Rico Heavyweight Championship, being placed over Shane Sewell on September 26, 2009. After WWC closed its 2009 season, he participated in a tryout for World Wrestling Entertainment (WWE) held in December, signing a developmental contract immediately after concluding his performance. In the first event of 2010, Euphoria, Colón was placed over his cousin and WWE wrestler, Eddie Colón. During the following months, the stable was systematically dismantled, Mulero received a gimmick change and returned as an unrelated masked wrestler, while Pérez left WWC to work for Combat Championship Wrestling and American Combat Wrestling. Ultimately, Colón dropped the Puerto Rico Heavyweight Championship and left the promotion to join Florida Championship Wrestling. At Aniversario 2010, he was booked to win his sixth WWC Puerto Rico Heavyweight Championship, which he went on to lose to Carlitos on September 25, 2010. At Septiembre Negro 2011, he won his first WWC Caribbean Heavyweight Championship over Chavo Guerrero. In his last days with the company, Colón had a minor role as a booker.
On March 4, 2009, Pro Wrestling Zero1 based in Japan, announced that Colón would debut in the company. His inclusion was as part of a heel faction named "Premium Wrestling Federation" or P.W.F., led by Steve Corino, which was "invading" the company. In his debut, he was teamed with Sonjay Dutt to perform against Shinjiro Otani and Ikuto Hidaka. The P.W.F. won this match-up at the 15:09 mark, when Colón utilized his finisher move, Orlando's Magic, on Hidaka to score a pinfall. Subsequently, all members of the P.W.F. participated in a sketch that involved invading the residence of several young Pro Wrestling Zero1 performers. In only his second appearance within the promotion, Colón was booked in a championship contest against Shinjiro Otani, for the World Heavyweight Championship. The match-up was won by Otani, who utilized his finisher, the Spiral Bomb, to score a pinfall. Meanwhile, the WWC promoted his participation in Japan as a "test tryout". The company avoided mentioning Colón's heel character in Pro Wrestling Zero1, and continued booking him as a face until Camino a la Gloria 2009.
Colón debuted on March 11, 2010, teaming with Johnny Prime and Incognito and being booked to defeat Tyler Reks, Derrick Bateman and Vance Archer.The promotion's creative team gave him a new ring name "Tito Nieves", which was quickly changed to "Tito Colon". Subsequently, his character was revamped as a masked wrestler called "Dos Equis" (After the Dos Equis beer), while Incognito was renamed Hunico and their team was named Los Aviadores (Spanish for "The Aviators") On June 3, 2010 Los Aviadores defeated the Uso Brothers to win the Florida Tag Team Championship. Shortly after, his character was renamed again, now being known as "Dynamico" and then "Epico". On July 15 Los Aviadores lost the tag team titles to Kaval and Michael McGillicutty, but regained the titles the following day in a rematch. On August 12, 2010, Epico and Hunico lost the tag team championship to Johnny Curtis and Derrick Bateman in a three-way match, also involving the team of Donny Marlow and Brodus Clay. Following this, his gimmick was changed back to Tito Colon. In mid-2011, he joined a stable known as The Ascension or La Ascención led by Ricardo Rodriguez, which also consists of Conor O'Brian, Kenneth Cameron, and Raquel Diaz.
On the November 4 episode of SmackDown, Colón made his debut on the main roster as a heel, under the Epico name but without the mask, losing to Sin Cara by disqualification after interference by his Los Aviadores tag team partner Hunico, who Sin Cara had recently unmasked. The following week, Epico and Hunico teamed up in a winning effort against the Usos, with Epico's cousin Primo in Los Aviadores' corner. Epico then began teaming with Primo, with Rosa Mendes as their manager, where they defeated The Usos on the November 17 episode of WWE Superstars. They then began a feud with WWE Tag Team Champions Air Boom (Evan Bourne and Kofi Kingston), defeating them in tag team and singles matches. On December 18 at Tables, Ladders & Chairs, Epico and Primo failed to capture the WWE Tag Team Championships from Air Boom. Their feud with Air Boom continued in singles and non-title matches, with both teams trading victories.
At a Raw live event on January 15, 2012, in Oakland, California, Epico and Primo defeated Air Boom to win the WWE Tag Team Championship. The following night on Raw, Primo and Epico successfully defended their titles against Air Boom in a rematch. On the February 27 edition of Raw, Primo and Epico retained their titles in a Triple Threat tag team match against the teams of Kofi Kingston & R-Truth and Dolph Ziggler & Jack Swagger. In the pre-show of WrestleMania XXVIII, Epico and Primo successfully defended their titles against the Usos and Justin Gabriel and Tyson Kidd in a triple threat tag team match. On the April 30 episode of Raw, Epico and Primo lost the titles to Kofi Kingston and R-Truth. In May, Primo, Epico and Mendes joined A. W.'s talent agency. At No Way Out, A.W. turned on them during their #1 contender Fatal Four-Way tag team match and aligned with the Prime Time Players (Titus O'Neil and Darren Young). The following night on Raw, Primo and Epico defeated the Prime Time Players by count-out after O'Neil and Young walked out of the match. The teams continued their feud on WWE Superstars, where Epico lost to Young and Primo beat O'Neil in singles matches. At Money in the Bank, Primo and Epico defeated Young and O'Neil in a tag team match. The feud ended in August when A.W. was released from WWE. At the Survivor Series pay-per-view, Epico took part in a 10 man elimination tag team match, but was eliminated by Tyson Kidd. Primo & Epico could not find any wins after August 2012, and by the first SmackDown of 2013, Primo was on a 20 match losing streak, and Epico was at 17. On the January 9, 2013 episode of NXT, Primo & Epico broke their losing streaks with a win over Bo Dallas and Michael McGillicutty. However, Dallas & McGillicutty gained revenge by defeating Primo & Epico in the first round of the NXT Tag Team Championship tournament to crown the inaugural champions.
On the August 19, 2013 episode of Raw, a vignette was aired introducing a new tag team known as Los Matadores, which was Primo and Epico wrestling as masked matadors. Later, on the September 30 edition of Raw, Primo and Epico debuted as Los Matadores, a face team of two masked Spanish bullfighters with El Torito as their mascot and faced 3MB in a winning effort. On April 6, 2014 Los Matadores faced The Usos, Rybaxel, and The Real Americans on the WrestleMania XXX Pre-show in a Fatal four-way Elimination match for the WWE Tag Team Championship in a losing effort. On June 23 WWE.com reported that Fernando was injured at a live event that past weekend. He returned to action on the August 19 episode of Main Event, teaming with Diego in a loss to Slater-Gator (Heath Slater and Titus O'Neil). On the WrestleMania 31 pre-show, the two faced Tyson Kidd and Cesaro, The Usos and The New Day in a Fatal 4-way tag team match for the Tag Team Championship in a losing effort. After more losses, the group showed signs of dissension as one of the matadors attacked El Torito, only to receive a 3D from The Dudley Boyz. The two ceased appearing on TV.
From April 4 to May 9, 2016, several videos aired on Raw promoted the return of Primo and Epico, who revived their Puerto Rican gimmick under the new name The Shining Stars. On the May 16 episode of Raw, The Shining Stars made their debut, defeating a team of local competitors. On the November 7 edition of Raw, after R-Truth sold The Golden Truth's Survivor Series spot for a stay at a timeshare to The Shining Stars, both teams competed to qualify for the 10–on–10 Survivor Series Tag Team Elimination match, which Team Raw won. The Shining Stars were confirmed to be in the Andre The Giant Memorial Battle Royal at WrestleMania 33, however neither of them were successful in winning the royal. During the 2017 WWE Superstar Shake-up, they were moved to Smackdown Live, reverting to the Colóns gimmick.
Finishing moves
As Fernando
Double knee facebreaker
As Epico
Backstabber (Double knee backbreaker) - adopted from his cousin
Signature moves
Belly-to-back suplex
Butterfly suplex dropped into a double knee facebreaker
Flying clothesline
Flying forearm smashes
Gory special
Monkey flip
Slingshot elbow drop
Slingshot somersault senton
Springboard tornado DDT
Standing hurricanrana sometimes while performing a baseball slide
Swinging neckbreaker
Tripleta (Belly-to-back suplex followed by a German suplex followed by a brainbuster)
El Torito
Entrance themes
"Let Battle Commence" by Daniel Nielsen (FCW; 2011; Used while a part of The Ascension)
"Wrong Time (A)" (November 4, 2011)
"Barcode" by Jack Elliot (November 17, 2011 – June 28, 2012; used while teaming with Primo)
"Enchanted Isle" by Jim Johnston (July 13, 2012 – January 9, 2013; used while teaming with Primo)
"Olé Olé" by Jim Johnston (September 30, 2013 – September 8, 2015; used while teaming with Diego)
"Shining Star" by CFO$ (May 16, 2016 - April 18, 2017; used while teaming with Primo)
"Primos" by CFO$ (April 18, 2017 – present; used while teaming with Primo)
Florida Championship Wrestling
FCW Florida Tag Team Championship (2 times) – with Hunico
PWI ranked him #76 of the top 500 singles wrestlers in the PWI 500 in 2012
World Wrestling Council
WWC Caribbean Heavyweight Championship (1 time)
WWC Puerto Rico Heavyweight Championship (6 times)
WWE Tag Team Championship (1 time) – with Primo
Epico Colón Wikipedia
Epicocconone
Epicoccum nigrum
David Austin (actor)


text:
Q: symbol(s) not found for architecture arm64 (M1 mac) I'm trying to run my c++ program with the following line:
  g++ -I/Library/gurobi950/macos_universal2/include -L/Library/gurobi950/macos_universal2/lib model.cpp -lgurobi_c++
But I get the following error:
  ld: symbol(s) not found for architecture arm64  clang: error: linker command failed with exit code 1 (use -v to see invocation)
Hope someone knows what is going on. I have a M1 macbook.
Thank you!
Actualization! The library works, when I compile it with a makefile, but when I try in the terminal it does not. This is the actual line I'm trying.
g++ -o main -m64 -g -Wall -I/Library/gurobi950/macos_universal2/include -L/Library/gurobi950/macos_universal2/lib model.cpp -lgurobi_c++
But the error it throws is still the same.
p.d.: I'm new to c++ and gcc.


Home > World > Germany: After Paralyzing Railroads, Strike Takes to Skies!
ORIGINAL FRENCH ARTICLE: Allemagne : après avoir paralysé le rail, la grève gagne le ciel !
Germany: After Paralyzing Railroads, Strike Takes to Skies!
Lufthansa pilots extended their strike to long-haul flights on Oct. 20. It's the eighth strike in the year. Train drivers struck for 50 hours over Oct. 18-19.
Since the beginning of the year, the pilots of the German airline, Lufthansa, have been fighting corporate management over the conditions for early retirement. The Vereinigung Cockpit (VC) trade union had already announced a strike beginning at 1 p.m. on Oct. 20, and on Oct. 21 for short and medium-haul flights. On Oct. 20 it warned that long-haul flights would also be affected on Oct. 21.
Lufthansa management announced on the evening of Oct. 19 that it was cancelling 1,450 flights concerning over 200,000 passengers because of the strike, which followed a work stoppage by train drivers over the Oct. 18-19 weekend.
The air and rail strikes come as school holidays begin in nearly half the 16 German Länder.
VC, which represents some 5,400 Lufthansa pilots, wants to keep the rules that allow pilots to retire from age 55 and to receive 60% of their salary until retirement at age 65. The trade union has proposed a plan to cover the cost of the measure.
For its part, Lufthansa management is proposing to maintain the set-up for workers who joined the company before this year. But it wants to up the retirement age for new hirees as soon as possible.
Over the Oct. 18-19 weekend, Deutsche Bahn train drivers held a 50-hour strike, the third strike in less than two weeks. The strike paralyzed two-thirds of the national trains. The GDL trade union is demanding a 5% wage hike for 20,000 drivers and a reduction in the work week from 39 to 37 hours. It also wants to be able to negotiate wage contracts for all rail workers.


We doubt you'll find anywhere better than this sensational first floor apartment where you get two bedrooms for the price of one! Having no stairs and secure lift access straight from the car park makes it ideal for downsizers . . . this is young, modern, stylish, spacious, superbly presented and very well appointed throughout, and yes it is even PET FRIENDLY . . . you will love it! Of special mention is the tiled open plan living area filled with an abundance of morning light, opening to your private outdoor balcony with a natural gas outlet and the bonus of an amazing NORTH EASTERLY aspect. Serviced by its own Ensuite, the bedroom is an excellent size and also has a large mirrored built-in-robe plus direct access to the balcony. The study or potential 2nd bedroom is HUGE and is serviced by a fully tiled bathroom, built-in-robes and internal European laundry. As you would expect in any LUXURY home, a quality GAS kitchen with Caesarstone bench tops and genuine pantry space, fully tiled bathrooms, down lights, split system air conditioning and much much more! ! Located within a recently completed small boutique unit complex and conveniently situated within easy walking of Kellyville shopping plaza!


Two methods to find theme words for any article, keeping LSI in mind.
How well themed are ghost written articles? What about those PLR articles you are having written? How do they measure up with the top pages in Google?
hi Andy – love your other videos. Sadly the one that's suppose to be on this page is missing. Can you help?
I'll have to do another one for this page as the old one was out-dated.


Intracellular pH is important in many functions that take place in a cell. For example, pH affects protein structure and the function of lysosomes, mitochondria, and other organelles. Changes in energy metabolism also often correlate with pH changes, and so scientists would like to monitor ATP and pH in a cell simultaneously.
Figure 1a. The researchers transfected Neuro-2A cells with a single fusion construct of pHRed-Perceval targeted to the plasma membrane and the nucleus. The Andor Revolution DSD was used to collect both widefield and confocal signals at a single z-plane through the center of the cells using a 40X 0.95NA air objective. The widefield image is on the left, and the confocal image is seen on the right. Only the green Perceval emission is represented in the image.
The Andor Revolution DSD confocal microscope is helping Dr. Gary Yellen's lab at Harvard Medical School develop genetically encoded fluorescent sensors for monitoring metabolism of single cells. "We are interested in sub-cellular compartmentalization of metabolites, and the optical sectioning afforded by the DSD allows us to assess the distribution of our sensors when they are genetically targeted to different cellular locations (e.g., plasma membrane, mitochondria, etc; Figures 1a and 1b)," he says.
Dr. Yellen's research team recently developed a genetically encoded pH sensor that could be used with GFP-based ATP sensors (Figure 1.) This type of probe was needed to monitor ATP and pH changes in a cell and to correct for the pH sensitivity of ATP sensors. They used the red fluorescent protein mKeima as a basis to engineer a genetically encoded ratiometric pH sensor they named pHRed. The sensor has a fluorescence emission peak at 610 nm and dual excitation peaks at 440 and 585 nm that allow ratiometric imaging.
Postdoctoral research fellow Mathew Tantama imaged energydependent changes in cytosolic and mitochondrial pH with the Revolution DSD, demonstrating pHRed's capability to monitor intracellular pH in living cells. "The Andor Revolution DSD offered us a practical, cost-effective solution for optical sectioning with the flexibility of a white light source," Dr. Yellen says. The microscope's broadband prefiltered light source and user-selectable filters gave the researchers access to a wide variety of excitation wavelengths. "During the process of sensor development, color requirements often change, making the fixed wavelengths of laser-based systems constraining or cost-prohibitive for an individual lab," he adds. The unique optical architecture of the Revolution DSD enables capture of both conventional and confocal fluorescence images simultaneously. This feature provides further flexibility for the researchers who can choose between the sensitivity of widefield and the resolution of confocal imaging according to conditions and experimental requirements.
Figure 1b. The widefield and confocal signals were simultaneously acquired with the Andor DSD system, and data are shown for a representative line profile through a cell (left) and a representative axial intensity profiled through the nucleus (right). Subcellular compartments such as the plasma membrane and nucleus are better defined in the confocal image compared to widefield, allowing more spatially accurate measurements. The wide field mode of the DSD is useful when spatial variation is minimal but more sensitivity is required.
The researchers transfected the pHRed sensor and the mVenusbased Perceval ATP/ADP sensor into live cells. For intensity ratio imaging they imaged the cells on an inverted microscope equipped with a Revolution DSD system controlled by Andor iQ software. Ratio imaging of the two sensors used excitation filters 445/20 nm, 482/18 nm, or 578/16 nm filters. The DSD unit contained a 59022bs dichroic, 492 nm short pass, 490 nm short pass, and 590 nm short pass filters. Emission light was passed through 525/39 nm or 629/56 nm filters. They typically acquired images every 10 seconds with 2×2 binning and 50 to 400 ms exposure times using a 20X/0.75NA objective. The speed performance of the Revolution DSD allowed imaging of several wavelengths at multiple XY positions while maintaining an adequate temporal resolution.
After capturing the images, they subtracted background and bleedthrough of Perceval fluorescence into the pHRed channel before calculating ratios. At the shared wavelength of 445 nm there was little bleedthrough during excitation. The researchers calculated pixel-by-pixel ratios, identified regions of interest around cells, and calculated averaged measurements using thresholding with ImageJ software. They found that pHRed's intensity ratio responds with an apparent pKa of 6.6 and a greater than 10-fold dynamic range.
Figure 2. Mouse primary astrocytes (pictured above) as well as neurons were transfected with a single fusion construct of pHRed-Perceval targeted to the plasma membrane and nucleus. Data acquired with the DSD confocal microscope (graph above) demonstrates that the sensors report neuronal response to glutamate challenge (t = 20 to 40 min) with a decrease in ATP/ADP but astrocytes did not. All cells responded to lowering of extracellular glucose (t = 70 to 120 min). In this experiment, images in 4 separate color channels at 4 stage positions were taken at each time point with only the green Perceval emission being represented in the image.


Denver — In the 2013-2014 school year, Centennial Middle School saw nearly 200 major office referrals, in an effort to discipline students. By the 2015-2016 year, that number went down to 45—and that was thanks to the efforts made by school principal Joe Simo, who joined the Centennial team at the beginning of that year.
From student behavior and the ways staff handled disciplinary actions, to repairing a fractured staff that couldn't agree on the future of Centennial, he was able to oversee a 180-degree shift in the building's culture. That's why the Colorado Association of School Executives and the Colorado Association of Secondary School Principals is proud to name Simo the 2018 Colorado Middle School Principal of the Year.
When Simo was first hired, he said, he was tasked with "getting student discipline under control and repair[ing] the culture of the building." Centennial staff was divided—some wanted the school to transition into a Charter model, while others felt it should continue with business as usual. Without a solid administrative foundation, student behavior was rebellious, and staff wasn't prepared to handle it.
So, one of Simo's first missions was to build strong relationships with his new coworkers. He proved his commitment to the school by spending hours researching ways to appease both sides of the fractured staff, eventually settling on a School of Innovation proposal. Providing Centennial with School of Innovation status would allow them the flexibility of a charter school, he said, while keeping the security of the district.
"On our last school performance framework, we were the highest performing school in our district," that teacher added. Even as a school with a 57 percent free and reduced-lunch student population, Centennial has become a performance school with a high growth in ELA and math.
By providing Centennial with School of Innovation status, Simo was able to offer students more classes. He introduced engineering courses, robotics and Spanish, he was able to bring them a drama club and a class called WIN—What I Need.
When it came to the student behavior, Simo approached them with that same humble spirit. Nothing he asks of his staff or his students is above his own pay grade, he said.
Simo will celebrate his win with a school assembly later this year, and at the April CASE Awards Reception, where he'll be honored along with other 2018 winners.


text:
El Campeonato Mundial de Baloncesto Sub-19 de la FIBA 2015 fue la XVII edición del torneo. Tuvo lugar en Heraklion, (Grecia), desde el 27 de junio hasta el 5 de julio.

Primera fase

Grupo A

Grupo B

Grupo C

Grupo D

Segunda fase

Octavos de final

Definición puestos 9°-16°

Definición puestos 13°-16°

Décimo Quinto Puesto

Décimo Tercer Puesto

Definición puestos 9°-12°

Undécimo Puesto

Noveno Puesto

Cuartos de final

Semifinales

Tercer lugar

Final

Estadísticas

Posiciones globales

Líderes

Puntos

Rebotes

Asistencias

Referencias

2015
Baloncesto en Grecia
Deporte en Grecia en 2015
Competiciones deportivas mundiales celebradas en Grecia
Baloncesto en 2015

redpajama_set_name: RedPajamaWikipedia


text:
Q: What does it mean for $\mathcal{C}$ to be a $\mathcal{D}$-module, when $\mathcal{C}$ and $\mathcal{D}$ are categories? If $\mathcal{C}$ is a module over a category $\mathcal{D}$, what does this mean? I looked around on line but couldn't find a definition.
My guess is that this means there is a functor $\mathcal{D}\to\operatorname{End}(\mathcal{C})$ from $\mathcal{D}$ into the category of endofunctors on $\mathcal{C}$? And so objects of $\mathcal{D}$ give endofunctors on $\mathcal{C}$, and the arrows in $\mathcal{D}$ give natural transformations of endofunctors, all encoded in a functorial way?


text:
INTERVIEW: Expanding Devenish Highlights Evolving Nature of Market
5 November 2020 - In 2018, Devenish signed a major refinancing deal to support the company's growth to 2026.
The long-term funding package of EUR 118 million has helped support growth across the group, bolstering R&D and manufacturing capabilities, as well as facilitating M&A activity.
Despite challenging market conditions, the company remains optimistic about delivering on its objective of increasing turnover by over GBP 100 million to reach approximately GBP 315 million by 2021.
Richard Kennedy, CEO of Devenish, told Feedinfo in an interview: "Although we are expanding, Brexit and COVID-19 slowed our organic growth. We have put the infrastructure in place; be it manufacturing footprint, staff numbers, expansions, and we launched our global innovation centre. I am confident that we will hit the numbers and remaining targets of the investment period. I am pleased with our performance in general."
And for 2021, Kennedy predicts a similar pattern.
"We aim to continue investing in our R&D, delivering on commercialising our research, and ensuring the profitability of our business and the businesses of our partners," he said.
2021, however, will not be without its challenges for Devenish, namely the lingering effects of COVID-19 and the resulting economic effects, as well as Brexit.
Kennedy commented: "COVID-19 has no doubt created a tectonic shift in how businesses operate globally. COVID-19 for sure slowed down business in some of our markets but also sped up plans in others. There were ups and downs globally, but we have been diligently and successfully working to offset disruptions."
"In fact, we saw opportunities coming out of COVID-19. It has opened a few windows and generated new sales for us. It's also been an occasion to get a lot more out of existing resources and focusing on essentials," he added.
Richard Kennedy
Devenish Nutrition
Kennedy also mentioned the recovery from the fire Devenish experienced in November 2019 at its distribution centre in Belfast.
"Be it the fire or COVID-19," he said, "we have proven to be very resilient and we reacted to market conditions very quickly."
Being a Northern Ireland headquartered business, Devenish is naturally keeping an eye on all Brexit related matters too and constituted a team which has been working on the issue from day one.
"Any barriers to trade are going to impact export-oriented companies. But it's the prolonged period of economic uncertainty surrounding Brexit and the government deadlines which have affected us the most," Devenish's CEO said.
"The Northern Ireland protocol did bring in some certainty. However, its implementation will be key, be it for external or internal market access. For us that is pivotal," Kennedy went on to say, adding that there will undoubtedly be increased costs, especially from an administrative standpoint, and these will have to be absorbed somehow along the supply chain.
The Premix Market is Changing
Established in 1952, Devenish has manufacturing sites across Ireland, the UK, US, Mexico, Turkey and Uganda, and employs more than 750 people. The company trades in over 50 countries. Traditionally labelled a premix business, Devenish describes itself as more of a specialist in optimising nutrients across the food chain to improve food quality, human health and the environment.
"We see ourselves as nutritionists, developers of sustainable solutions for effective use of nutrients, more like innovators in the feed industry," Kennedy argued.
"Premix is evolving and is increasingly integrating such solutions. So rather than a premix company, we are more of a sustainability business," he added, putting special emphasis on the R&D side of Devenish's operations which is an integral part of the company's strategy.
Currently approximately 15% of Devenish's revenue is reinjected into R&D, but Kennedy considers R&D as the core aspect of what his company does and the impact such efforts have on customer operations.
"Every time we sell something, we monitor performance at customer level. We work with customers to make sure they are also environmentally and financially sustainable," he commented.
In Northwest Europe, Devenish's traditional premix market, the competitive environment has intensified and the company was quick to realise that to grow in such a context it had to innovate and think out of the box in order to play a role that has impacts on the whole food supply chain.
"What's crucial for a premix business is to move beyond commoditised premixes and the exposure to market volatility associated with the segment," he said. "Premix today is more of a focus on the utilisation of nutrients and their added value. So, premix businesses must bring something new to the market."
Kennedy added: "They must also continue to find partners as more capacity is required. We've even seen some companies leave this market, only to come back. And it's important to work with the full supply chain you are in. Smaller premixers can be valuable partners at a local level."
Global premix markets are characterised as fragmented. This leaves room for some strong regional brands. With COVID-19 and companies renewing their interest in regional/local expansions, Kennedy doesn't see why animal nutrition businesses can't be both global and local.
"At Devenish, we aim to be local with access to global innovations, finding local partners to drive efficiencies throughout the full supply chain," he said.
"I see a future with more animal nutrition companies looking at collaborations and licensing of their technologies or even production sites to local partners. The IT sector did this years ago by setting up server farms across all locations. Why can't we do it too?" he added.
Expansion Projects, M&A and Raising Equity
Over the years Devenish has grown its business and expanded dramatically.
For instance, the company partnered with Yem-Vit in Turkey in 2017, acquiring a 50% stake in a Turkish nutrition business in the process. This move provided Devenish with manufacturing capabilities closer to some of its key export markets. It was another step in the internationalisation of the business, giving an opportunity to expand further in the Turkish and surrounding markets.
"We have an emerging markets strategy," Kennedy stressed, highlighting some more recent developments.
"In the US, we will have grown from two when we first started there, to six manufacturing sites by the end of the year," he said. "In Mexico, where we already have offices, we are expanding and will open a new manufacturing plant early next year. Also, we have set up new business in Chile and in other areas."
In his view, emerging markets want to capitalise on Devenish's knowledge and the company is seeing the demand in these areas.
"Premix is a route to these markets. We then bring in the technologies and make them applicable," Kennedy added, bringing up the example of Jamaican poultry firm Caribbean Broilers with whom Devenish signed a GBP 30 million, 10-year R&D and supply agreement in April this year. As part of the agreement, Devenish will build a Poultry Performance House on Caribbean Broilers estate in Jamaica, where joint research and development trials will take place.
"This is an important development in Devenish's international growth and a significant milestone in the rollout of our Performance House business model worldwide," he said.
"At Devenish we prefer to take a partnership approach with our customers. Like with Caribbean Broilers, we have set up, with the help of Tyson Foods in the US, additional Poultry Performance Houses which enable the application of our technologies at poultry producer level," Kennedy added.
"COVID-19 has certainly accelerated our way of thinking about M&A and the focus on fostering local opportunities. We need to be more open-minded in terms of mergers. And we believe there is value in partnering with non-premixers," Devenish's CEO went on to say.
"Today," Kennedy confided, "we are looking at raising equity to build our global footprint and we are exploring all types of options, be it with private equity companies or industry partners."
Kennedy shared that Devenish is having ongoing discussions with the industry in its search of strategic partners. He also said his firm is examining a potential IPO.
"I am fully confident in our future. We have seen significant growth in our sustainability solutions and we're looking to keep on growing."


Evgeny Add is a graphic artist from central Siberia who works in the genre of hyperrealism. "I believe that in the 21st century, a modern artist should keep pace with the times and try to use modern techniques and approaches in creating his works. There is no difference between then hand-brush or stylus from the tablet. The main idea of my works is a complete rethinking of existing real forms, creatures, people and other things for creating new compositions, new meanings. Compositions from the simplest forms give birth to new more complex things and meanings. The absence of a context gives rise to a certain identity, gives a fresh look to the habitual way of life. The human body is interesting in itself. Attention to detail gives an unlimited field for creativity. The process of degeneration of something complicated by means of splitting it into simple fragments gives a very interesting effect in the compartment with graphical means of expressiveness. In fact, this is a new visual language with a huge variation in everything that happens in the plot".
Jc Trouboul is a Spanish artist born in 1985. He showed an interest in art, particularly painting and drawing, from a young age. JC Trouboul studied architecture in Barcelona, and his love for art and design influenced much of his work. Artist JC Trouboul pays homage to ambassadors of British culture, power and compassion. Treated as royalty, JC Trouboul constructs through colour and texture the reflection of their resilient spirits. These two pieces were painted in unison, thought to work together or on their own.
Ksenia Sic is a Serbian born artist living and working in France. Ksenia has exhibited extensively in Europe since 2014 and has also completed Artist residences across Europe including in Switzerland, Iceland, Belgium and Finland. Her work incorporates acrylic and gold leaf on canvas, producing portraits that are visually striking. "In her art, Ksenia Sic is displacing herself as an observer. She does not paint portraits of certain specific individuals. Her paintings are neither representations or selfies. Each of her paintings is actually a portrait of the state of modern man and society as a whole, a society in which the illusion of the uniqueness of the Icon is unachievable on the horizon of the ocean of commonness" – Milan Poznanovic, Art historian.
Louise Allen began her life as an artist as a child. She studied faces wondering who she looked like. She painted and drew people, then after leaving Art School she embarked on a creative life. For years other opportunities and work took her away from portraits. After leaving her role as a Lecturer in Art she began to paint people again, finding her life experiences gave her a sense of ease as she gently observes the sitter's character and works to create paintings that represent their whole self.
There is a unconscious nod to folk art in Louise's work that is unintentional and was a curiosity to Louise. She recently learnt whilst painting her birth mother that her maternal grandmother was the first generation of Romany Gypsies to live in a house. Creating paintings and art was traditionally part of her gypsy family way of life.
Ulku Yilmaz is a Turkish artist who has exhibited extensively since 2005. The new series of deeply personal paintings by Istanbul-based artist Ülkü Yilmaz are a meditation on desire and lack as constitutive of the human subject. The artist has stated that though skulls play a prominent role in these paintings, these works are decidedly not in the vanitas tradition. Instead, they are in much closer by Melanie Klein which defines art as 'passion transformed'. So, rather than meditating on the brevity of life, ethical concerns, futility, etc…, the skulls in these paintings represent sensuality, or, more specifically, a world of sentiment. In this sense, one could see these works as evoking the private world of Antigone, in that, Antigone does not give way on her desire.The figure in the painting is lovingly holding the skull, this remnant/memory of the body held in fidelity to the life cherished and loved, and she is keeping the skull for herself. In this act she is alienating the viewer, not leaving space for the viewer's subjective interpretation. She never gives her full face to the viewer. The viewer must enter into the image and feel her experience, not interpret it through the lens of (art) history, but feel it in its immediacy. This approach to art is akin to both Francis Bacon's project of 'painting sensation' and Baudelaire's intention to be the 'poet of nerves'.
Liz Kori is an artist from South London with a degree in BA Illustration. "My work is very bold and illustrative in its nature. For me, It's all about the face; capturing human expressions and emotions in one shot. I use the contrast of bright colours and dark lines. I'm inspired by the cool flair of film noir, the vibrant colours of world cinema and lyrical poetry. There's no perfection or imperfection when it comes to Art but I want to catch your eye and stop you in your tracks".
Rhianna Catt is a young British watercolour artist from London who loves to paint portraits, trying to express each person's personality through each painting. She is completely self-taught through trial and error and the internet and is exhibiting for the first time in London. "When I sit down to paint I reach a certain point of calmness and a state of relaxation, where my inner most thoughts come to express themselves through my brush, as I spread the watercolour across the paper seeing my ideas and thoughts come to life; it is my way of trying to make sense of the world and people around me".


text:
Uber to Become the Sole Owner of Grocery Delivery Startup Cornershop
Uber has reached a deal to become the sole owner of Latin American delivery startup Cornershop, just one year after acquiring a majority stake in the company. The ride-hailing giant said in a regulatory filing Monday that it will purchase the remaining 47% interest in Cornershop in exchange for 29 million shares. The transaction is expected to close in July.
Uber announced in 2019 plans to take a majority ownership in Cornershop. That transaction wasn't completed until the third quarter of 2020 other than in Mexico, which closed in January 2021. This latest agreement, which was reached June 18 and reported Monday, will make Cornershop a wholly owned subsidiary of Uber. The deal is a logical next-step in the Uber-Cornershop relationship, a source familiar with the matter told TechCrunch.
The deal suggests Uber's bullishness in delivery hasn't waned. With Cornershop as wholly owned subsidiary, Uber can beef up its grocery delivery options, a service made popular during the pandemic. The company started offering grocery delivery in select cities across Latin America, Canada and the U.S. last summer after it acquired Postmates in a deal valued at $2.65 billion. Uber CEO Dara Khosrowshahi said in a statement that the company's grocery and new verticals business has exceeded a $3 billion annual bookings run rate for this year.
Source: Techcrunch


Slieve Donard (via the Glen River) – Northern Ireland's. – Slieve Donard at 850m (2,789 ft) is the highest of the Mourne Mtns. The views from the summit are extensive and on a clear day the Isle of Man, Wicklow, Donegal, Wales and Scotland may be seen, as well as the long stretch of Newcastle Beach.
where can i move to start over Walmart made a game that lets you see what it's like to work at one of their stores – here's how to play – Over the course of your workday. to switch between the places you need to perform tasks. You start each day in the back room, where you have to complete all your work before you can move into your.
How do you know when to give up? | Gentle Doberman – · Wow—that photo of Griswold reminds me SO much of how Ziva's right ear does when she gets tired. Her ears will stand perfectly until she gets sleepy, then that.
How Much is My House Worth? Local Home Value Estimates — ERA – Use home value estimates as a starting point. Home value estimates are a great place to get an idea of what your house is worth today. For more details, use the pricing tool to instantly customize your estimate.
fha guidelines for manufactured homes Requirements for the Inspection of FHA insured mobile homes – The Federal Housing Administration, an agency within the Department of Housing and Urban Development, offers various insurance programs for affordable housing. Certain mobile homes, known as.hud meaning real estate What Does HUD House Mean? | Sapling.com – A HUD house is listed for sale through a local real estate broker or agent contracted by the department. agents promote hud homes much like they would other foreclosures and non-foreclosed properties.
So how much is your house really worth? – Gloomy predictions of a meltdown in the UK's residential property market have come to nothing. Far from collapsing, house prices have risen beyond their February 2008 peak to a new record, according.
A loophole helped McAllen hide how much it paid Enrique Iglesias. The Texas House on Wednesday moved to patch it. – REUTERS/Carlo Allegri Looking to close a loophole in Texas public records laws that was made infamous by the pop singer enrique Iglesias, the Texas House on Wednesday. Do you value our journalism?.
Camel Tank- Auxiliary Fuel Tanks | Adventure Rider – · I've been in on the secret for some time as one of the test fitters Cory has used. Gotta give him credit for a ton of work he's done to get this tank designed and ready to manufacture; the few others that hinted at this type of tank in the works have not had the determination to get anywhere near this far in.
Aventus Creed for men – Fragrantica.com – The hype about this fragrance is due to its versatility. You can blind buy this and 99% you will like it! The pineapple and green apple notes are unique, superb, exquisite and have been copied by many clones since, yet this remains my favorite in the group, in spite of high price.
How Much Is Meghan Markle's Engagement Ring Worth? The Rock Is So Gorgeous – The couple made their official announcement in a statement from the Clarence House. on either side are from my mother's jewelry collection to make sure that she's with us on this crazy journey.
use home equity to buy rental property hud meaning real estate Definition of a HUD House | Home Guides | SF Gate – Additionally, a real estate agent with access to the Multiple Listing Service (MLS) can locate hud-owned homes in a buyer's area of interest.Is It Better to Buy or Rent a Second Home? – I merely want to address whether a second home is a good financial investment. Let's compare the two options. You can use a portion of your savings to buy a second home, or you can invest the same.hard money loan monthly payments where can i move to start over Walmart made a game that lets you see what it's like to work at one of their stores – here's how to play – Over the course of your workday. to switch between the places you need to perform tasks. You start each day in the back room, where you have to complete all your work before you can move into your.How to pay off your mortgage early – If you're ready to get a jump-start on paying your mortgage off sooner than the loan terms say you should, here are a few ways to get started. If you have a 30-year loan, you can refinance to a 10- or.
Rental Truck Help LLC – MOVING LABOR NEAR ME – Ranked #28 in the Nation on Hireahelper also ranked 1st in Dallas-Ft.Worth with a 100 mile radius in 2018. Over 900 jobs through Hireahelper alone.
How much is my house worth? Depends on who you ask – What's my house worth? That's an easy question to ask, but a difficult and complex one to answer. Usually the questioner is a homeowner who wants to know how much they can sell their house for now if.


2-U Technology, LLC was founded by enterprising young people with a desire to provide complete technology solutions for their clients needs. With many successful projects to our credit we continue to grow and provide better services to our clients. Today we continue to expand our experience and technical expertise in providing the right solution to our customers, with concentrations in IT cloud solutions and managed services.
Select Adobe Flash Player ActiveX. prof. Windows Error Support Home About Contact Terms Trademarks: Microsoft Windows logos are registered trademarks of Microsoft. Reply paulina says: October 31, 2011 at 04:53 WOO MAN!
How to Chat Online Copyright © 2016. You now have a backup of your Adobe Flash Player-related registry entry. Select Adobe Flash Player from the list of displayed program list. Thank you Hyperborean Reply DanielV says: November 5, 2010 at 03:36 DUDE YOUR MY HERO!!!
You don't have to hire a professional and spend hundreds of dollars on repairs. program, uninstalling and reinstalling your Error 2046-related program will likely be the solution to your problem. Re: Error #2046? Finding the exact driver for your Error 2046-related hardware device can be extremely difficult, even directly on the Adobe Systems Inc.
What can be preventing me from viewing the image? Have you restarted your comp? 2. Either increase the storage space or delete the Flash cookies. We do not guarantee that problems resulting from the incorrect use of Registry Editor can be solved.
If you are still having trouble after following these steps, please try completing this process for your other Web browsers. Close the dialog when you're done. If you would like to chat with people on webcam chat sites such as Chatroulette, Omegle, Omegle Lady Zone and Funyo, you may get such errors. Open the problematic website. 2.
NBittinger May 18, 2012 2:01 PM When I attempt to login at formscentral.acrobat.com, the login form successfully submits and begins launching the application. Thank you so, sooooo much. : ) Reply Tom says: May 17, 2015 at 21:13 Worked great for me.. A Quick Guide to Fixing Error 2046 Home > Windows > A Quick Guide to Fixing Error 2046 PC Support Hotline: 1-844-377-4107 Resolve Error 2046 Error 2046 - What is it? Error Tools Editor's Choice.
Once that's done, restart the web browser and repeat the same steps but this time click enable button. Step 5: Utilize Windows System Restore to "Undo" Recent System Changes Windows System Restore allows you to "go back in time" with your PC to help fix your Error 2046 problems. This is a next generation and a multi-functional PC Fixer embedded with a powerful antivirus and a registry cleaner. Re-Enable Flash Player Add-on Adobe Flash Player add on is basically installed in IE (Internet Explorer) which is loaded each time you load IE.
You have a corrupt cache. because the truth is that I had time I could not solve this problem Reply Chris says: November 26, 2011 at 08:17 I have followed your directions to get rid of Check the boxes of the categories you want to clean and click OK. Select Tools -> Manage Add-Ons. 3.
Please enter a title. Reply Bill Green says: May 17, 2015 at 13:53 Excellent advice. I also cleared my cache and all Adobe cookies. We also share information about your use of our site with our social media, advertising and analytics partners.
These troubleshooting steps get progressively more difficult and time consuming, so we strongly recommend attempting them in ascending order to avoid unnecessary time and effort. salaries: gross vs net, 9 vs. 12 months Why does argv include the program name? Restore your computer. DO NOT hit ENTER yet!
blog:15173:4::0 Tweet More about error 2046, error code 2046, error 2046 windows 7 Latest News Top News Police hacked to death in Myanmar as Islamist claims pique fears U.S., Canada ban Deselect Automatically Detect Settings Checkbox In Local Area Network (LAN) Settings, there is a checkbox which is used to detect automatic settings for your LAN internet. windows-8.1 video flash-player share|improve this question edited Aug 23 at 7:54 Burgi 2,0913929 asked Jun 7 '15 at 14:38 Rod 62531836 add a comment| 1 Answer 1 active oldest votes up Follow the on-screen directions to complete the uninstallation of your Error 2046-associated program.
How? Alphaverse.comLife, the Multiverse and Everything... Type "regedit" and hit ENTER. Download a good antivirus software from here.


text:
Q: How To Monitor Download Progress of Stream From SharePoint, I get a "Stream" for a file. I want to copy this entire file from the internet to a local file on the PC, but I want to have status while this download is occurring. How? FileStream and StreamReader seem to have bytes vs char differences when not doing a full "CopyTo" which doesn't have progress updates. There has to be a cleaner way...
using (var sr = new StreamReader(fileData.Value))
{
    using (FileStream fs = new FileStream(localFile + "_tmp", FileMode.Create))
    {
        byte[] block = new byte[1024];
        // only guessing something like this is necessary...
        int count = (int)Math.Min(sr.BaseStream.Length - sr.BaseStream.Position, block.Length);
        while (sr.BaseStream.Position < sr.BaseStream.Length)
        {
            // read  requires char[]
            sr.Read(block, 0, count);
            // write requires byte[]
            fs.Write(block, 0, count);
            Log("Percent complete: " + (sr.BaseStream.Position / sr.BaseStream.Length));
            count = (int)Math.Min(sr.BaseStream.Length - sr.BaseStream.Position, block.Length);
        }
    }
}

A: Just had to use BinaryReader instead of StreamReader. Easy Peasy.


shocked coming it white travelling injuries The in minor staye"We are just shocked and numb and coming to terms with what has happened.
They found that Numb is required for cells to maintain the correct balance between stem cells and differentiated cells in the gland.
Team Comfortably Numb was given the project by its sponsor and co-inventor, Mehdi Razavi, a cardiac electrophysiologist at the Texas Heart Institute.
I had a disc that was nicking on my sciatic nerve and my leg was going numb during games.
Numb chin syndrome normally presents as unilateral numbness along the lip and chin with patients describing effects feeling similar to local anesthesia.
Numb and Numbl are highly conserved, meaning that they're nearly identical in mice, humans and other animals, a sign that they're likely very important.
My left arm went numb I was taking so much cocaine.
The 31-year-old was sleeping when she woke up to find her hand going numb.
Lewis Hamilton, pictured above, was left feeling numb after failing to finish his final race for McLaren on Sunday despite starting on pole position and leading the race.
They must, use an amazing amount of anesthetic on politicians since I can only imagine how-much it would take to be numb to the truth.
It was so shocking that it made me numb straight away and I have not really got the feeling back yet,'' he told a national TV programme.
Canals, rivers and ponds may look appealing to youngsters but within a shocking 30 seconds of falling into freezing water, the body can go numb and hypothermia sets in.


In total 16 players will participate, 11 qualifiers as per regulations (listed below) plus 4 nominees from the organisers (to be announced) plus 1 nominee of the FIDE President (to be announced).
3. Mamedyarov, S (Average Rating List 5/2013 to 4/2014).
Each player will play in 3 tournaments and all his results will be taken into account for the overall final standings of the Grand-Prix.
The qualified players mentioned above shall download their participation contract from here and return it signed to the FIDE Secretariat, as scanned email or fax, by the deadline of 27 August 2014.
Da hat sich die FIDE ja mal wieder selbst übertroffen. Zwei Turniere an denen mindestens ein Spieler aus politischen Gründen nicht teilnehmen kann - Aronian wird in Baku sicher nicht spielen, Gelfand darf unter Garantie nicht in Teheran teilnehmen. Warum überlässt man es nicht den Spielern, an welchen Turniern sie teilnehmen möchten?


text:
Tribunal fees deterring employees from suing employers
A shock drop in the number of claims being taken to employment tribunals has sparked a reaction from the top trade union body.
In response to new figures published by the Ministry of Justice, the TUC said tribunal fees are deterring workers from taking action against their employers. staras
Employers committing wrongdoing against their employees are increasingly likely to escape punishment, according to the Trade Union Congress in a press release on Thursday. The TUC said there was a 59 per cent drop in the number of single claims being taken to employment tribunals. These numbers showed that new fees were deterring workers from taking action against their employers, the TUC said.
TUC General Secretary Frances O'Grady said in the press release: 'If an employer breaks the law and sacks someone unfairly, sexually harasses them or cheats them out of their wages, it's understandable that an individual should want to seek some kind of redress.' She added that the drop is not due to nicer employers over the past year, but said that filing a complaint against a bad employer has become too expensive for many workers, and that it is 'just plain wrong'. The figures show an 85 per cent fall in the number of claims for unpaid wages between January and March 2013 to the first three months of 2014. Over the same period, sex discrimination cases were down 80 percent and unfair dismissal cases were down by 62 per cent. Source: TUC Press Release.


text:
July 14, 2019 @ 9:30am » Andrew HolleranShares 84
Photos: Meet The Wife Of Wimbledon Finalist Roger Federer
Mirka Federer (front row C), wife of Switzerland's Roger Federer, and Federer's father Robert Federer (front row L) watch as Roger Federer serves against Spain's Rafael Nadal during their men's singles semi-final match on day 11 of the 2019 Wimbledon Championships at The All England Lawn Tennis Club in Wimbledon, southwest London, on July 12, 2019. (Photo by Adrian DENNIS / POOL / AFP/ Getty Images)
Roger Federer is playing for another championship at Wimbledon this morning, as the 37-year-old tennis legend is taking on one of his longtime rivals, Novak Djokovic, in the final match of the historic tournament.
This would be Grand Slam win No. 21 for Federer, who defeated his biggest rival, Rafael Nadal, in the semifinals. Federer last won at Wimbledon in 2017. He has eight total wins at the legendary tournament.
Mirka Federer, the wife of the tennis star, is in the stands supporting her husband today, like she's been all tournament.
The wife of the tennis legend is a former player herself, having represented Switzerland during her career. She had some injuries during her career before becoming Federer's public relations manager.
The couple first met at the Australian Open in 2000 and married in 2009.
Switzerland's Roger Federer and his girlfriend Mirka Vavrinec (L) arrive at the Shanghai Pudong International Airport on November 6, 2006 to attend the Shanghai Tennis Masters Cup which begins November 12, 2006. (Photo by Osports/Getty Images)
Mirka Federer is often quite emotional during her husband's matches. Who can blame her for that, after all, as he's been a part of many of the sport's most jaw-dropping moments.
LONDON, ENGLAND – JULY 12: Mirka Federer attends day eleven of the Wimbledon Tennis Championships at All England Lawn Tennis and Croquet Club on July 12, 2019 in London, England. (Photo by Karwai Tang/Getty Images)
LONDON, ENGLAND – JULY 12: Tony Godsick and Mirka Federer attend day eleven of the Wimbledon Tennis Championships at All England Lawn Tennis and Croquet Club on July 12, 2019 in London, England. (Photo by Karwai Tang/Getty Images)
Federer has often praised his wife for how well she's handled everything over the years. The couple has four children – two sets of twins.
"My wife does a lot of work, as much as she can. And I try to help as much as I can.
"We have the grandparents as well and all my team members, they sometimes just tag along.
"Clearly we also need some help on the road, so Mirka can have an opportunity sometimes to sleep in a little bit, or come to watch one of my matches.
"You need to be well organized, but by now we know how it works," he said.
Perhaps we'll see Roger and Mirka celebrating another Grand Slam win in a couple of hours.
Federer and Djokovic are currently in the first set of their championship match.