Description: "Rationing Means a Fair Share for All of Us," a 1943 Office of Price Administration poster promoting rationing of food and other items during World War II. This style of poster was aimed at promoting conservation of resources during World War II by showing civilians how they could contribute to the war effort through their everyday activities. View on Ohio Memory.
Description: "Keep the Home Front Pledge," a 1944 poster promoting conservation of resources during World War II and cooperation with government rationing. View on Ohio Memory.
Description: "Do With Less - So They'll Have Enough," a 1943 Office of War Information poster promoting rationing on the home front during World War II. This style of poster was aimed at encouraging the conservation of resources during World War II by showing civilians how they could contribute to the war effort through their everyday activities. View on Ohio Memory.
Description: "Americans! Share the Meat as a wartime necessity," a 1942 Office of War Information poster about rationing of meat. This style of poster was aimed at promoting conservation of resources during World War II by showing civilians how they could contribute to the war effort through their everyday activities. It is identified as OWI Poster No. 10, distributed by the Foods Requirement Committee of the War Production Board. View on Ohio Memory.
Description: "Food Is a Weapon," a 1943 Office of War Information poster promoting maintenance of a healthy lifestyle and conservation of resources during World War II. This style of poster was aimed at showing civilians how they could contribute to the war effort through their everyday activities. View on Ohio Memory.
Description: Cartoons by Billy Ireland, a long-time editor of "the Passing Show" page of the Columbus Dispatch. These cartoons refer to recommended restrictions on wheat and other supplies due to wartime shortages during World War I. America, characterized as Uncle Sam, is seen embracing cornbread as an alternative to traditional wheat bread. This image was included in a "Memory Book" compiled by Mrs. H. V. Cottrell, historian for the Clinton League (sometimes called the Clinton Welfare League) from 1938-1943. The book shows the development of the Clintonville neighborhood of Columbus, Ohio, and records the history of the League. The Clinton League was a women's group founded in 1912 to promote child welfare and later general welfare in Columbus, but which was based in and primarily focused on the area of Clintonville. View on Ohio Memory.
Description: "War Shipments Mean Less Fuel for All," a 1943 Office of War Information poster promoting a sense of common purpose during World War II and encouraging civilians to dress warmly to preserve oil and fuel for military transport purposes. View on Ohio Memory.
Description: Printed list of "The Club Women's Sugar Slogans," composed by Roy Snively of Clintonville. These slogans were related to the voluntary conservation of foodstuffs like sugar and wheat on the homefront during World War I. This image was included in a "Memory Book" compiled by Mrs. H. V. Cottrell, historian for the Clinton League (sometimes called the Clinton Welfare League) from 1938-1943. The book shows the development of the Clintonville neighborhood of Columbus, Ohio, and records the history of the League. The Clinton League was a women's group founded in 1912 to promote child welfare and later general welfare in Columbus, but which was based in and primarily focused on the area of Clintonville. View on Ohio Memory.


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Home Politics Marco Rubio:Biden Bank Nominee 'Supports Communist Policies'
Marco Rubio:Biden Bank Nominee 'Supports Communist Policies'
Sen. Marco Rubio, R-Fla., blasted President Joe Biden's nominee to lead the Office of the Comptroller of the Currency, saying she supports communist policies on Friday.
"Saule Omarova supports abolishing private bank accounts, using govt to bankrupt energy companies & creating a Soviet style 'National Investment Authority,'" Rubio wrote on Twitter.
"She supports communist policies & a communist should not be our Comptroller of the Currency," Rubio added.
Saule Omarova, a Cornell Law School professor, has recently faced criticism for allegedly supporting Marxist policies, criticism which was reiterated Thursday during her hearing in front of the Senate Banking Committee.
Omarova was born in the Soviet Union and graduated from Moscow State University in 1989, the Daily Caller News Foundation reported. Her past writings on Marxism called for an overhaul of America's banking industry.
Omarova also praised the now-defunct Soviet government for its lack of a "gender pay gap" in a 2019 tweet.
"Until I came to the US, I couldn't imagine that thing like gender pay gap still existed in today's world. Say what you will about old USSR, there was no gender pay gap there. Markets don't always 'know best,'" Omarova wrote on Twitter in 2019.
Omarova has also criticized the financial sector, calling it the "quintessential asshole industry" in a 2019 documentary, the Daily Caller News Foundation reported.
Biden's nominee also wrote a college thesis titled "Karl Marx's Economic Analysis and the Theory of Revolution in The Capital." Sen. Pat Toomey, R-Pa., the ranking member of the Senate Banking Committee, sent a letter to Omarova demanding that she turn over the thesis by Oct. 13, which she still has yet to do.
In the book "The Seven Sins of Wall Street: Big Banks, Their Washington Lackeys, and the Next Financial Crisis," Omarova was quoted praising Marxist policies, saying they changed her view of the world, the Daily Caller News Foundation reported.
Omarova has also called to "'end banking,' as we know it" by advocating for a system where Americans have government bank accounts with the Federal Reserve that would "fully replace—rather than compete with—private bank deposits."
Sen. John Kennedy, R-La., went after Omarova during the hearing Wednesday, saying, "I don't know whether to call you professor or comrade," after pressing her on her previous memberships in Marxist organizations.
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There are a few SEO-related things that we only need to review perhaps once a year, such as reassessing the titles and descriptions and mapping out the internal linking. If you never get around to these, it's not the end of the world. At the other extreme, there are what should be almost weekly tasks, including checking into Google Search Console, and monitoring positions for key search terms.
In the middle are quite a few jobs that get neglected: potential problems if you don't do them, but never quite important enough to get to the top of the to-do list. It's these which I think smarter people put on a 3-monthly schedule.
The first is taking an in-depth look at Google Analytics – not just the headline traffic, but the pages getting viewed, the sources of traffic, the geographical location of visitors and the tech being used to view the site. You don't really want to identify long term trends two years after they became a really significant factor.
A second task is a full site crawl to identify broken links, missing tracking codes, accidental noindex tags and the like. As frequently mentioned here, the pro tool of choice is Screaming Frog SEO Spider. Less costly or free workarounds are available.
Finally, check the robots.txt file and XML sitemap(s). Are they up to date and doing what you want them to do? It's amazing how often these get inadvertently amended or automatic updates fail.
Get those items covered if your website health matters to you, and you'll sleep easier.
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The Unspoken Consequences of Bombing Syria
Now that U.S. bombs are falling in Syria, will Islamic extremism be stopped in its tracks? Such a question is an insult to the intellect, yet it's the dominant theory in Washington D.C., where years of Middle East war have taught politicians nothing.
Not only will bombing yet another Middle East country create yet more extremists, the bombings in Syria are likely to broaden an already-existing proxy war between regional rivals. Obama's strategy to combat ISIS purposely excludes key players that, if included, could actually help stop the fighting. The strategy of exclusion will thus intensify the regional proxy fight, leading to the likelihood of even deeper U.S. involvement in the Syrian war and a broader conflagration.
Iran, Syria, and Russia were not invited to join the war against ISIS, since the broader regional proxy war is a war between the U.S. and its allies versus Syria, Iran, Hezbollah and Russia.
Syria cannot join the anti-ISIS coalition even though Syria has been fighting ISIS for over two years. Obama's reason is that the Syrian government has "no legitimacy." But Obama's "coalition" of Gulf states are composed of totalitarian dictatorships that, in comparison, make Syria look like the bastion of democracy.
Equally hypocritical is that Obama's Arab bombing partners are the states most responsible for ISIS' creation. Saudi Arabia and Qatar are especially guilty of sending money, weapons, and extremist fighters into Syria to topple the Syrian Government, which directly helped transform ISIS from a fledgling group of fanatics into a regional power.
While Saudi Arabia and Qatar were exporting jihadism, Obama looked the other way, so pleased was he to have an army of foreign mercenaries to help topple Assad. These extremists dominated the Syrian battlefield for nearly three years, and only now Obama is using a couple of beheadings to flood the emotions of the American public.
Obama's "coalition of the willing" is largely a mirage, since it's composed of Gulf state monarchies that are completely dependent on U.S. aid, which supplies these dictatorships with enough fire power to protect them from their own citizens, who would otherwise topple their "royalty" in minutes.
Further enraging the Gulf state population is their governments helping the U.S. bomb another Arab country; the U.S. is disliked as much as the hated dictatorial monarchies.
To complicate matters more, there are large sections of support in the Gulf states for groups like ISIS, since these governments give institutional support to religious institutions that hold an extremist interpretation of Islam.
In fact, the only thin base of popular support for these dictatorships is religion, which is why these theocratic regimes cannot wage a real war on Islamic extremism — their thin political base will not support their monarchy bombing familial-religious offshoots. Thus, Obama's coalition of regional lackey dictatorships cannot give too much support — or support such a war too long.
The real danger of bombing Syria is expansion. Once the first bomb explodes, the logic of war takes over, usually creating a dynamic of expansion. The U.S. military uses the sanitized term "mission creep" to explain this phenomenon. And the war is already starting to creep; Obama has already bombed non-ISIS targets, which has enraged some Syrian rebels.
An even larger "mission creep" is easily predictable because Obama's main strategy to fight ISIS is to arm the rebels who are fighting the Syrian government. The rebels are more interested in fighting Assad than fighting their ideological cousins.
The New York Times recently confirmed this, as they mentioned that Syrian rebels dislike ISIS, but "…ousting Mr. Assad remains their primary goal, putting them at odds with their American patrons."
Obama himself finally admitted in his U.N. speech that targeting the Syrian government was at least half of his intention by funding the Syrian rebels:
"Together with our partners, America is training and equipping the Syrian opposition to be a counterweight to the terrorists of ISIL and the brutality of the Assad regime."
Of course, no politician tells the U.S. public that funding the Syrian rebels is being done to attack the Syrian government.
The above New York Times article also mentioned that the U.S. is currently paying the salaries of 10,000 fighters in northern Syria. This is a mercenary army, and thus a manufactured war. The U.S. is paying 10,000 fighters while Saudi Arabia and Qatar have long been paying "rebels" to fight the Syrian government. This cash-flush Syrian mercenary army has artificially expanded the catastrophic Syrian war that Assad would have otherwise won long ago, saving tens of thousands of lives in the process.
The likelihood of "mission creep" was recently discussed by legendary Middle East journalist Robert Fisk:
"How soon… before a missile explodes in a Syrian regime weapons depot — by "mistake", of course — or other government facilities? Since the US has decided to fund and train the so-called "moderate opposition" to fight Isis and the Syrian regime, why should it not bomb both sets of enemies?"
Fisk is, of course, correct; investing in the Syrian rebels is likely an investment in a longer-term war against the Syrian government. Now that the U.S. Congress approved $500 million in funding for the Syrian rebels, the U.S. is more likely to "come to their defense" if they engage in a large battle with the Syrian government.
The U.S. politicians understand that the intended outcome of funding the Syrian rebels is regime change, while they tell the American public that ISIS is the only target. The real agenda is quite simple: keeping the Middle East under U.S. control by any means necessary.
Socialists on Palestine and Israel: One or Two States?
How Obama and Al-Qaeda Became Syrian Bedfellows
In Syria, Obama and al-Qaida share the bed


The September 30th countdown continues. Read the Telegraph article here.
Tip of the TinFoil to StandFirm.
Actually why not invite everyone to Lambeth, but hold two separate types of meetings … one working fully together as constituent members. Agenda: missions, covenant, etc. The other to be held between constituent members and associate members, you know for tea and listening to one another. This would fit into the scheme Williams offered previously, would save face so all get to come to meet at the table, but only some get to be involved in the actual business of the communion. Those Americans who would not be allowed in as constituent members could show up and listen (or have others listen to them I suppose) but the work of the communion could go on seriously among those who abide by its previous rulings, and subscribe to its discipline.Just a thought. Not like I'm waiting by the mailbox for my invite.
Ah but that's the beauty of the process. If the Americans do not attend they can no longer say they are interested in listening … or that they are full members of the communion. No matter how hard they try the spin that they are the victims here, it would be their choice not to participate, not to come and try to have an impact on the less sophisticated bishops who merely need to meet more GLTB folk to change their minds.And they would be free to come as constiuent members if they renounced the choices they made to place them in the second tier. You see the best way forward I think is to leave the responsibility for choosing in the hands of someone other than the ABC. That would actually make each person responsible for their own choices and the consequences …Wouldn't that be a novel thing these days, wot?


Juicy J Tickets | Catch the Southern Rapper Live in 2019!
Stay Trippy with Juicy J LIVE in 2019 with Tickets for Less!
Iconic Southern hip-hop star Juicy J — best known as one half of the Academy Award-winning duo Three 6 Mafia — is releasing his fifth studio album, Rubba Band Business, and he's bringing his supporting tour to a concert venue near you in 2019! Tickets are available for all performances, so if you're a fan of old-school hip hop, you'll want to check out his schedule below. And lucky for you, because you've come to BigStub, you're just a click away from the best Juicy J tickets around... no matter how much you're looking to spend!
So don't miss your chance to see one of the biggest names in Southern hip hop as he performs new cuts and old favorites. Find out more about upcoming performances from the calendar below, and get your set of Juicy J Tickets from BigStub today!
When you're looking to catch the biggest hip hop tours of the year, look no further than BigStub, your one-stop shop for amazing tickets on the web! With over 10 million tickets for more than 100,000 unique live entertainment events in our extensive database — the Juicy J tour included — we can help you out no matter what your interests or your budget. Explore our website to learn more about the great concerts, sporting events, theater performances, and more that are headed your way in 2019 — just be sure to grab your Juicy J Tickets today!


* Build strong working relationships with your stakeholders.
Randstad is seeking a highly motivated Part Time Onsite Recruitment Consultant to provide excellent customer service to a major client. You have will have the option to work 3 - 4 days.
Ideally, the successful candidate would come from a blue collar recruitment environment and consider themselves a guru on all matters pertaining to industrial relations and HR best practices. They would have developed the ability to build instant rapport with employees and clients and would have fine-tuned their administration, HR and customer service skills.
In addition to the above, the successful candidate will be self-driven, vibrant, passionate and have the ability to maintain a high level of personal motivation at all times. This is an excellent opportunity to develop and progress your career.
The successful applicant will be provided with an amazing opportunity to join a group of highly motivated and quality professionals that collectively form the highly cultured and successful Randstad team. The successful candidate will also be provided with all the necessary tools to be successful in this role.
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If this sounds like the role that you have been waiting for, please apply now.


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It really does feel like I am writing an essay, it took me sometime to actually decide to start on it, because knowing myself this post will spiral out of control mainly because my life with Nuffnang and the bloggers/friends since my encounter with Nuffnang is a very blissful and eventful one.
It's definitely like a roller coaster, full of fun and thrills.
My first screening from Nuffnang since i join is "Super 8"
It was the first time I met the rumored bloggers of Nuffnang community, it was freaking awesome. I met so many of them!
That's basically how my Nuffnang story started.
Soon enough I was active, I was more than myself more like I found a new and better self.
Something that I could relate to, something that could empower my visions and motivate me to do the great things that I should be doing.
It was not the fact that I have a chance to earn money from blogging or sharing but rather Nuffnang gave me a platform to meet people whom have different passion for different things but used blogging as a means of spreading their joyous moments.
It has not been long since I started actively blogging, but in these 4 months I have certainly learnt and grow much stronger and happier then who I was back then.
Laser Tagging was one of the first team bonding event and I got to know so many new faces there.
This was also thanks to MilkADeal for the oppurtunity.
From then on, events and get together seems like a part of my life now, it's not just the partying. It's partying with the right PEOPLE that matters.
The people who you can make fun off, joke around and laugh it all out. That's how it's always been around them.
Nuffnang was the guide, that took me into this world that i would never imagined myself to be in, and it is somewhere i tend to stay and defend with what ever I got.
With the friends, the moments and the days that would only have value because I choose to enjoy every part of it.
Henry, Eric, Jia Yeen, Caroline, Philippe, Edwin, Jackie, Yeong Boon.
Ysquare, Chutipond, KenWooi, YeeIng, Qian, ShiiTeck, Kian Fai, Isaac, Ryan.
The list goes on and the fun, excitement and the inspirations plus the motivations are endless and always renewed with even more new faces for me to meet, everyone is so awesome, and thought me a lot about the things I have not seen.
This is the story of not just Nuffnang, the story of how Nuffnang was the one who gave me a chance to meet these great people.
So as the list grows, the more I learn and the more I strive in my passion to blog and to do multiple things my way through my perseverance and passion.
Every blogger is never alone, and when there is a gathering like this, to honor these hardworking and selfless bloggers. You better be there!
Come 16 December 2011, 500 bloggers from around the Asia-Pacific region will flock to Kuala Lumpur, Malaysia for the Nuffnang Asia-Pacific Blog Awards 2011 in Putrajaya Marriott.
The Awards aims to not only honour the region's best bloggers, but also to bring together blogger communities from across Asia-Pacific.
The Nuffnang Asia-Pacific Blog Awards is brought to you by Volkswagen Malaysia and Putrajaya Marriott.
Photos used are from Facebook mostly and other bloggers.
wahaha, i love my afro so much in this post~! who saw me ? wahahaha~!
awwww. such a sweet post!
a great post indeed! it's an honor to know you too!!
i'll know u if i wasn't off to work 4months ago. hahaa..
I m sure we will meet up one day.
XD wah can make people warm and fuzzy. better den booze!
I don think all is here oso. paiseh.
seriously a great post to read!


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Scotland confirms increasing rate of drug-related deaths
July 17, 2019 by meziesblog.com, posted in News
More than 1,100 people died from drugs in Scotland last year, new figures indicate, the worst level since records began.
There were 1,187 drug-related deaths registered in 2018 – above 1,000 for the first time and up 253 (27%) on the previous year.
The National Records of Scotland statistics indicate Scotland's drug death rate is nearly triple the UK rate and the highest in the European Union.
It is at its highest level since current records began in 1996 and more than double the 2008 figure of 574.
The health board area with the highest proportion of drug deaths in 2018 was Greater Glasgow and Clyde at 394 (33%).
Deaths from opiates or opioids, such as heroin, morphine, or methadone, were implicated in, or potentially contributed to, 1,021 deaths.
For benzodiazepines such as diazepam and etizolam, this figure was 792.
Men accounted for the majority (72%) of the drug-related deaths. The 35-44 age group was associated with the most deaths at 442, followed by those aged 45-54 (345).
The Scottish government has vowed to get a grip on the spiralling number of deaths relating to drugs.
Scotland's Public Health Minister Joe FitzPatrick said the country faces an "emergency" on this issue.
He said: "The number of people who have lost their lives because of drug use is shocking.
"It is vital this tragedy is treated as a public health issue, and we are prepared to take innovative and bold measures in order to save the lives of those most at risk."
He said he asked for help in persuading the UK Government to either act now to enable Scotland to implement a range of public health focused responses – including the introduction of supervised drug consumption facilities – or devolve the power to the Scottish Parliament so that it could take action.
"I want to ensure that the work of the new taskforce which I have established is driven by strong evidence and the voices of those with experience of using drugs, and their families, are heard," he said.
"I am determined to shape our services in every walk of life to prevent harm and reduce the appalling number of deaths.
"So I will give consideration to any proposals they bring forward which may help to tackle this issue and, ultimately, save lives."
From the 1,187 deaths, methadone – a synthetic opiate used as an alternative to heroin which is prescribed by doctors – was implicated in, or potentially contributed to, 560 deaths.
Heroin and/ or morphine were also implicated in, or potentially contributed to, the cause of 537 deaths (45 per cent of the total).
In total, 1,021 deaths were related to heroin or other opiates.
Benzodiazepines – a class of psychoactive drugs which includes anti-anxiety drugs – were involved in 575 drug deaths.
Most of the drug-related deaths are of people who took more than one substance. Just 68 of the 1,187 deaths where only one drug, and possibly alcohol, contributed or possibly contributed to the cause of death.
More than three people a day (3.25) die from drugs in 2018.
Of Scotland's estimated 5.4million population, there are around 58,900 problem drug-users in the country.
Tagged drug abuse, Scotland
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Frank Dominianni/Hi-Speed Automotive - Legendary Driver
in Legends Lost
Last Updated: 26 February 2019
So much has been written about Frank over the span of his long career and you'll still never find a complete synopsis of his wit, engineering prowess and mechanical spirit. Being friends of his led him to come in and give us an incredible interview, and unfortunately, we could never get him back for another. Respecting his wishes we never bugged him about it, and we're happy to have this one to share with you.
Here's how Frank Dominianni sounded on MotorMouth Radio back on Aug. 14, 2005.
Here is an excerpt from a blog article on Scotty Gosson Exposed! on Frank:
While I was busy with my little experiment, Motormouth Ray was unwittingly stumbling across one that he had initiated years earlier. It's still bearing sweet fruit today. Take it, Ray...
Hi-Speed Automotive as it sat until Frank's passing in 2011....lost in time.
Time stood still in this display cabinet at Hi-Speed.
There was a very popular speed shop in Valley Stream Long Island (one town over from us) that I used to go to when I was in high school. The name of the shop was Hi-Speed Equipment, and the owner was a very wise and crafty man named Frank Dominianni. I just went there to buy small items, because I couldn't afford his knowledge of early Corvette fuel injection systems, nor a pull on his Clayton dyno.
Always magnanimous & wearing a smile for his friends, this is Frank Dominniani.
Fast forward to 2005, when I happened to see the front door of the dilapidated shop open. I wondered if it was being sold or emptied, as it hadn't been a working shop in many years. I walked over and immediately recognized the notably older Frank, sitting behind the desk. Cut to the chase: Frank had kept the shop and went there every day - rain or shine - just to keep a schedule. We became fast friends, and had many deep conversations about life, love, and the state of the world at large. We shared some deep mother issues.
We had Frank on the show once, in 2005 (see link on the Motor Mouth Radio home page), but I was never able to coerce him to come on again, due to his shyness. Frank passed away a few years ago, but his son Joe regularly sends me tidbits he finds while going through the contents of Frank's life (and he saved everything!). I could give you volumes of information on this iconic racer/fabricator/mechanic, but we'll get to that later. For now, I want to share with you a document that Frank received in 1963 and filed away. This is cool stuff...
A letter from Dodge Public Relations that was sent to Frank introducing the "new" Ramchargers engine program.
(Photos courtesy of Motormouth Ray) (Images courtesy of Frank Dominianni)
Here is link to an article on Hi-Speed Power Equipment from Hemmings.
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Al Krotoski
Wojciech Antoni "Al" Krotoski
(Physician and pro-life activist)
Born June 20, 1937
Died January 1, 2016 (aged 78)
Political Party Republican
Spouse (1) Danuta M. Krotoski (divorced)
(2) Judith Ann Goins Bell Krotoski (married 1985-2013, her death)
Religion Roman Catholic
Wojciech Antoni Krotoski, known as Al Krotoski (June 20, 1937 – January 1, 2016), was a physician in New Orleans and later Baton Rouge, Louisiana, who was active in the right-to-life movement, having frequently testified on family issues before the Louisiana State Legislature.
Dr. Krotoski was a pro-life giant, who forever changed the life landscape in the Louisiana legislature, nationally, and internationally -- The Reverend Gene Mills of the Louisiana Family Forum.
A citizen of Poland by birth, Krotoski was actually born in Riga, Latvia, where his father, Ludwik Krotoski, was the charge d'affairs of the Polish consulate. In 1939, his parents and two older siblings were living in Warsaw awaiting assignment when Nazi Germany invaded Poland and began World War II. With Poland abandoned to communism after the war, the Krotoskis managed to reach London, where Ludwig served the Polish government-in-exile until after the war. In 1949, the Krotoskis became British subjects but that same year immigrated to the United States. In 1955, they were naturalized as American citizens while residing in Los Angeles, California.[1]
Krotoski graduated in 1952 from Loyola High School in Los Angeles and began college at the age of fifteen, but he did not receive his Bachelor of Arts degree in bacteriology until 1960 from the University of California at Los Angeles. He entered graduate school and then medical school in 1961. In 1968, he received a Ph.D. in medical microbiology as well as his M.D. degree. He engaged in an internship at Gorgas Hospital, named for medical pioneer William C. Gorgas (1854-1920), in the former Panama Canal Zone.[1]
In 1969, he returned from the Canal Zone to the United States upon receipt of a commission in the Public Health Service. He was assigned to research malaria at the National Institutes of Health office in Chamblee, Georgia. In 1972, he undertook a residency in preventive medicine at the public health hospital in San Francisco. This training required him to visit tropical centers in Africa, India, and Southeast Asia. Having completed the residency in 1974, he received the Master of Public Health degree in epidemiology from the University of California School of Public Health at Berkeley. In the summer of 1975, he came to the public health hospital in New Orleans to establish a tropical infectious disease research program. He subsequently traveled to the Marshall Islands as a consultant in a radiological health program. This assisgnment included a visit to Bikini Atoll. In 1980, with the technical assistance of his former wife, Danuta Gwozdziowski, and others, he discovered the cause of relapse in malaria as a hypnozoite. For this endeavor, he was nominated in 1989 for a Nobel Prize in Physiology and Medicine. When the public health hospital system closed in 1981, Dr. Krotoski began work at the National Hansen's Disease Center in Carville in Iberville Parish near Baton Rouge. He worked there until his retirement in 1995. He was the author or co-author of fifty-five scientific papers and a reviewer on several editorial boards for medical journals. He continued after retirement to lecture extensively on subjects related to tropical infectious diseases.[1]
Krotoski was active in statewide and local pro-life organizations. He was the co-founder of The Hippocratic Resource and an elected member for two terms to the Louisiana Republican State Central Committee, a 144-member body which governs the activities of the state party. He was a member of St. Jude the Apostle Parish in Baton Rouge and the Roman Catholic men's order, the Knights of Columbus. His second wife, Judith Ann Goins Bell Krotoski (1945-2013), an occupational therapist who specialized in rehabilitation of the hand, was a native of Fort Worth, Texas. The couple married in 1985;[2] they were active in the Worldwide Marriage Encounter movement. Dr. Krotoski is survived by his daughter from the first marriage, Aleksandra Krystyna Theresa "Aleks" Krotoski, an American citizen, broadcaster, journalist, and Ph.D. social psychologist, about whom there is a Wikipedia biography. She was born in 1974 in Kuala Lumpur, Malaysia, and lives in the United Kingdom with her husband, Ben Hammersley, and daughter, Ripley (born 2014); a stepson, John Bell, IV; and his sister, Danuta (same first name as his first wife) K. Shaw, and her husband, Robert. A mass of Christian burial was recited at St. Jude the Apostle Catholic Church on January 8, 2016. He is interred beside Judith at Resthaven Gardens of Memory in Baton Rouge.[1]
Krotoski joined with Dr. Francis D. Rinaudo (1948-2020), a dentist from St. Francisville in West Feliciana Parish, in establishing the Hippocratic Resource Council, which has for decades assisted the pro-life cause.[3]
The Reverend Gene Mills, president of the Louisiana Family Forum in Baton Rouge, called Krotoski "a pro-life giant, who forever changed the life landscape in the Louisiana legislature, nationally, and internationally. ... He reminded us that words have meaning. He refused to refer to the practice of abortion with sanitized words. He consistently referred to 'abortion clinics' as 'abortion facilities' emphasizing the truth that 'clinics' are life affirming and life saving whereas 'abortion facilities' are not."[4] Krotoski presented the pro-life perspective on a variety of bills and will be remembered and honored as a voice for "an ever-greater respect for all human life, from fertilization until natural death."[4]
Other pro-life activists:
Cathie Adams
Angie Hammond
Joe B. Phillips
Christopher F. Young
↑ 1.0 1.1 1.2 1.3 Wojciech Antoni Krotoski. The Baton Rouge Advocate. Retrieved on January 6, 2016.
↑ Judith Ann Goins Bell Krotoski. Findagrave.com. Retrieved on January 6, 2016.
↑ Louisiana Family Forum, "Family Facts: Loss of a Giant: Dr. Rinaudo Steps into His Heavenly Home," January 28, 2020.
↑ 4.0 4.1 Gene Mills, "A Pro-Life Champion Goes Home!," Louisiana Family Forum, Baton Rouge, Louisiana, January 5, 2016.
Retrieved from "https://conservapedia.com/index.php?title=Al_Krotoski&oldid=1648933"
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This slick-looking new ball is be used in all of the Premier League games next season, and is the spiritual successor to last year's Premier League ball – the T90 Ascente.
The Nike T90 Tracer Premier League Football represents the pinnacle of Nike's football development. Taking much of the technology from the T90 Ascente, such as the dimpled surface which enhances air flow across the ball.
Nike claim that the graphics used on the surface of the Nike T90 Tracer Premier League' Football are designed to enhance depth perception (part of the Visual Performance science behind the Nike Elite Series Football Boots) making the ball easier to judge as it moves at high speed.
However, we've always been told that asymmetrical graphics were best for judging ball flight, so it'll be interesting to get some player feedback on this new ball's print!
Other features on the ball include a decorative decal to celebrate Nike's 10th anniversary of making footballs for the English Premier League.
The new Nike Premier T90 Tracer League Football will cost the handsome sum of £85 and is available to buy now.
Does anyone have a link for the replica ball please??
@kevlin, it's not out yet.
Thank god we haven't got that bloody Jabulani!


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Human Research Oversight Expands
Jill Wechsler
Jill Wechsler is ACT's Washington Editor
Applied Clinical Trials, Applied Clinical Trials-10-01-2001,
Columns | View from Washington
While Health and Human Services builds a comprehensive program to ensure the safety of human subjects, Congress weighs proposals to stiffen the rules.
When the Office for Human Research Protections shut down clinical studies at Johns Hopkins University in July, one objective was to send a strong message that OHRP will not tolerate lax oversight of human research by even the most eminent medical institution. Since it was established in June 2000, the Office for Human Research Protections in the Department of Health and Human Services has gained visibility for waving a big stick at noncompliant research organizations, while expanding the governments capacity for setting policy, monitoring studies, and educating all segments of the research community. OHRP director Greg Koski is leading the charge, working with other government agencies to build an aggressive oversight program.
OHRP is working closely with the Food and Drug Administration, which has established an agency-wide office to coordinate oversight of clinical trials and ensure that studies provide unbiased and sound data to support market applications. FDAs good clinical practice staff (which may be renamed Office for Human Research Trials) in the Commissioners Office of Science Coordination and Communication now oversees FDA bioresearch monitoring programs, in coordination with the Office of Regulatory Affairs and individual product centers. David Lepay, senior advisor for clinical science, heads the GCP staff; he represents FDA in meetings with other federal agencies and at external policy forums. Stan Woollen has moved from the Division of Scientific Investigations (DSI) in the Center for Drug Evaluation and Research (CDER) to assist Lepay, prompting CDER to name Martin Cohen, medical officer in CDERs Division of Oncology, to head up DSI on an acting basis. Health issues analyst Bonnie Lee rounds out Lepays GCP staff. The group plans to revise FDA Information Sheets for investigators and Institutional Review Boards (IRBs) along with other policy initiatives.
Congress weighs in
Administration efforts to step up oversight of clinical research may be encouraged by action on Capitol Hill. In August, the House International Relations Committee approved a measure that aims to protect individuals participating in clinical trials overseas. If finalized, this amendment to the Export Administration Act could require pharmaceutical companies to obtain approval from a U.S. IRB and from federal regulators to sponsor clinical studies in developing nations.
Members of Congress also are weighing new legislation to expand federal oversight of human research studies and to impose penalties on noncompliant researchers. Representative Diana DeGette (Democrat, Colorado) leads efforts in the House to enact legislation to codify certain human research protections for both private and publicly funded studies. Senator Ted Kennedy (Democrat, Massachusetts), chairman of the Senate Health, Education, Labor and Pensions Committee, may go further and offer legislation to establish a central federal clinical research agency, as recommended by the National Bioethics Advisory Commission. Kennedy also supports giving FDA and NIH the authority to levy fines on researchers who violate the rules, as an alternative to shutting down research activities altogether. Academic research institutions and industry sponsors are leery of added mandates and penalties. But the research community may encourage Congress to signal its support for stronger research oversight by increasing funds for OHRP and FDA to expand educational efforts and boost inspections of clinical study sites and IRBs.
Other than funding initiatives, Congress may hold off making major changes in human research policy until the Institute of Medicine (IOM) completes a broad assessment of the nations system for overseeing human research. The same IOM panel (headed by Daniel Federman of the Harvard Medical School) that issued recommendations for accreditation standards for research organizations in April (View from Washington, June 2001) has launched this broader project, due to be completed in the fall of 2002. OHRP requested this IOM review. The panel held meetings in May and August, and another is planned for November. One objective is to identify ways to measure system effectiveness in order to establish models for improvement.
During the August session, the panel examined the role of private-sector organizations in protecting human research participants. David Lepay described FDA policies and procedures for regulating commercial clinical trials. Bert Spilker (senior vice president, Pharmaceutical Research and Manufacturers of America, or PhRMA) described the role of industry sponsors, and Helen Wyn Davies (senior vice president, Quintiles) explained how large contract research organizations (CROs) operate. Davies noted that too often examinations of the biomedical research system focus on federal agencies, research institutions, and investigatorsleaving out sponsors and CROs. Increased outsourcing of clinical trials, she explained, has transformed CROs from subject recruitment and support providers to full partners in drug development that are well positioned to ensure the safe treatment of study subjects and maintain quality research programs.
Another group examining the research enterprise is the Human Subjects Research Subcommittee of the White House Office of Science Technology Policy. This government-wide panel chaired by Koski evaluates specific issuessuch as international research policiesas well as big-picture initiatives. For example, its SUEE task force on simplification, uniformity, efficiency, and effectiveness will meet in November to discuss ways to make government oversight more efficient. The subcommittee also plans to form a think tank to explore ways that a new, high-tech system could be designed to capture information in real time and prevent harm to research subjects.
And moving onto the stage is the White House Council on Bioethics, which President Bush announced in August as part of his program to permit limited government funding for stem cell research. The new panel will monitor studies of embryonic stem cells while also addressing broader biomedical issues. It may replace the National Bioethics Advisory Commission, which was scheduled to go out of business in October 2001. Bush raised some eyebrows by naming University of Chicago bioethicist Leon Kass to chair the council. Kass opposes cloning human embryos to derive stem cells, but supports adult stem cell research and is considered fair-minded and well-versed in the issues.
Meanwhile, Congresss General Accounting Office is assessing how well government agencies have improved research oversight since the death of Jesse Gelsinger, the first recorded gene therapy fatality, in fall 1999. These issues were discussed at the July meeting of the National Human Research Protections Advisory Committee, which advises Health and Human Services (HHS) and OHRP on specific policies. Participants at the meeting outlined a number of initiatives by OHRP, FDA, and the research community to address public concerns.
Improve IRB operations. OHRP and FDA have launched an online program to register all IRBs in order to facilitate oversight and enhance communication with IRB officials. All organizations that receive government research funding will have to register an IRB. FDA is developing a rule that would require registration of all IRBs regulated by the agency and hopes to issue it by year-end. In addition, an NIH Regulatory Burden Working Group is studying IRB operations to better assess resource needs.
Develop central IRBs. To improve the review and monitoring of multicenter trials, academic institutions and PhRMA are promoting increased reliance on accredited central IRBs. These bodies will demonstrate expertise in overseeing complex research studies and compliance with good IRB practices, which are being developed by a joint government/private-sector panel. FDA and OHRP would encourage this system by instructing all IRBs that an expedited review will suffice for a component of a multicenter trial that has been approved by an accredited IRB.
Improve trial monitoring. To help IRBs oversee ongoing studies, OHRP and FDA are encouraging research institutions and sponsors to make greater use of data and safety monitoring boards (DSMBs) to monitor research and evaluate adverse event reports. NIH has issued guidance supporting DSMB review of adverse events for certain multisite and high-risk studies, and FDA is developing additional guidance on DSMB use.
Separately, the Center for Biologics Evaluation and Research (CBER), which is responsible for regulating gene therapy research studies, is weighing new policies to improve clinical trials monitoring. CBER has formed a working group to evaluate the need for earlier agency review of sponsor monitoring plans to make sponsor oversight requirements clearer and more specific.
Clarify conflict-of-interest standards. HHS has issued a draft interim guidance on financial relationships involving investigators and institutions, largely to help IRBs and researchers evaluate proposals and programs. Academic institutions have complained that the agency is going too far in micromanaging research arrangements, and HHS is reviewing these comments.
Promote accreditation. HHS is pilot testing accreditation programs by nongovernmental organizations, as recommended by the IOM April report mentioned above. This initiative should be spurred by the August release of final accreditation standards by the Department of Veterans Affairs and the National Committee for Quality Assurance for VA-sponsored research.
Promote investigator training. HHS now requires investigators applying for NIH grants to meet educational requirements on human subject protections. A national educational summit in August recommended forming a national council to promote educational efforts.
Update informed consent policies. A main goal for OHRP is to reshape informed consent from a system that documents subject consent to one that promotes understanding of the research process as a prelude to voluntary participation. NIH is conducting studies on how well individuals can understand risks and benefits in research, and FDA is reviewing these issues.
Enhance adverse event reporting. HHS and FDA are working to reduce differences between their AE reporting requirements to make it easier for investigators to understand and comply with the rules.
To carry out these multiple assignments, Koski has organized OHRPs staff into units that reflect the agencys roles and responsibilities.Education. This division, headed by Jeffrey Cohen, provides training programs for professional societies, IRBs, and other government agencies on research policies and ethics. It co-sponsors workshops for investigators with organizations such as PRIM&R, and plans a series of town meetings to explain research practices and policies to the public.
Assurance and quality improvement. An important OHRP initiative under George Gasparis is streamlining the process for NIH grantee institutions to provide the required assurance that they will comply with research regulations. The online assurance system has approved about 800 federal-wide assurances, with 3000 expected in the long run. This division also is testing a quality self-assessment tool for human research protection programs that could lead to a site visit by the agency. OHRP aims to conduct 60 quality improvement interactions with research organizations each month, reaching all 125 accredited medical schools in the coming year.
Oversight. Kristina Borror leads OHRPs Division of Compliance, which investigates research institutions, primarily after receiving a complaint or learning of a potential problem. In addition, the agency is beginning to conduct not-for-cause site visits, which eventually will mesh with a voluntary accreditation program. A goal for Koski is to shift the perception of compliance from an administrative burden to an opportunity to learn about policies and how to fulfill responsibilities appropriately.
International policies. With human research increasingly global in scope, OHRP has established a small international affairs office headed by Melody Lin. OHRP is playing a lead role in developing federal policies related to the conduct of clinical trials overseas, including non-biomedical research.
Policies and planning. OHRPs policy office under Irene Stith-Coleman helps to assess and develop proposals related to a broad range of research issues, such as studies involving prisoners and children.
Koski acknowledges that OHRP cannot regulate some 5000 IRBs and hundreds of research organizations with a staff of fewer than 50 people. He regards the oversight of biomedical research as a distributed system with many key players, including Congress, the White House, and other federal agencies, along with public and private research organizations. The goal is a network of outstanding research organizations that use quality improvement tools to meet voluntary accreditation standards that ensure compliance with educational and oversight requirements.
View from Washington | FDA


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Adams 14 school district pays $5 million settlement to student sexually abused by teacher
COMMERCE CITY, Colo. — Adams County School District 14 has paid $5 million to settle a lawsuit filed by a former student who was sexually assaulted by an elementary school teacher.
Denver attorney Dan Sloane, whose law firm represented the student, said the victim was 9 years old when she was sexually abused by fourth grade Dupont Elementary School teacher Gilbert Trujillo in 2010.
Trujillo was convicted of sexually assaulting two students in 2017 and sentenced to 25 years to life in prison. He had originally been accused of assaulting six girls, but was convicted for two of the known victims.
Sloane said the district was aware Trujillo was engaging in inappropriate behavior with students as far back as 2007 and even issued a warning letter to Trujillo in 2008. That letter included a number of restrictions on Trujillo's interactions with students, Sloane said, including not being alone with them and, if he sat at a table with a student, staying on the opposite side of the table and keeping his hands on the tabletop.
"The egregious thing about this is it should never have happened," Sloane said. "He never should have been around her in 2010."
Sloane said Trujillo threatened the victim with violence if she ever reported the abuse, and the girl was so frightened she didn't tell her parents until they moved out of Colorado and she felt safe enough to do so.
In an emailed statement, Adams 14 spokesman John Poynton declined to comment on the case, citing a confidentiality agreement:
"It is not uncommon for school districts in Colorado to enter into settlement agreements to resolve disputed claims. Sometimes the parties agree that settlement terms are confidential. One reason a party may do so is to protect the privacy of a minor-aged student and prevent revictimization. When an agreement makes clear that all settlement terms are protected as education records under the federal student privacy law and requires all parties to maintain confidentiality, the District simply cannot comment at all about the settlement. Unfortunately, the District encounters a situation where a party or its attorney does not honor the confidentiality that was previously agreed to. Such situations are difficult because the District may be perceived to be unwilling to provide information it believes it cannot legally disclose."
Sloane said the settlement was reached in April and included $3.5 million paid from an insurance pool and $1.5 million directly from the district.
Sloane said the victim and her family hope the settlement drives reform at the school district.
"We hope it never happens again. We hope something meaningful happens at the highest level of the school district to prevent this from ever happening again," Sloane said.
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Thanks to the generosity of Florida State University's Department of Art alum Chuck Whited, the College of Fine Arts is pleased to be able to offer a range of more than 200 hand-painted backdrops for use in photo shoots, filming and more to the Florida State University family!
Chuck Whited earned his BFA in Studio Art in 1976. To help pay his way through school, he ran an airbrushing business in Panama City Beach on the weekends. His entrepreneurial spirit never died. Chuck moved to Atlanta where he worked in a number of production capacities. As Atlanta became an epicenter of filming in the U.S., Chuck responded to the growing need for backdrop rentals and custom-made sets with C&M Backdrops.
In 2007, Chuck joined the FSU College of Fine Arts Dean's Advisory Board. He worked as a mentor for students in film and art, and grew to know the excellence of FSU's many arts programs. He also learned about our needs.
After more than 20 years as the film industry's go-to company, Chuck Whited made a bold move. In Summer 2017, Chuck closed C&M Backdrops and donated his entire inventory of 236 backdrops to FSU College of Fine Arts. The gift will supplement sets in our many hands-on learning environments.
Whited may have hung up his hat in the backdrop rental business, but he continues to work as an artist, consultant, art director and executive producer in the film and television community. He is also a competitive cyclist and advocate for increased shared use paths, better awareness, and safety.


Bill Dagnall is the Assistant Vice President of Business Development for Greater Pensacola Operations. He is responsible for planning, organizing and directing Navy Federal's business development activities and strategies that promote brand identity and growth for the organization in Northwest Florida.
Bill has been employed with Navy Federal for 23 years, starting his credit union career as the Singapore Branch Manager in 1995. Prior to relocating to Pensacola in 2008, Bill held leadership positions within the organization in Jacksonville, FL and Virginia Beach, VA.
Bill currently serves on the Board of Directors for Florida's Great Northwest. He also serves on the Achieve Escambia Operational Support Team, Greater Pensacola Chamber Military Affairs Committee, Greater Pensacola Defense Community Alliance, and the Pensacola International Airport Air Service Development Committee. Bill is a graduate of the Greater Pensacola Chamber's Leadership Pensacola program (LeaP Class of 2014).
Bill obtained his bachelor's degree in Speech Communications from Valdosta State University in Valdosta, Georgia. He also holds Executive Leadership Certifications from Columbia Business School and Georgetown University's McDonough School of Business.
Bill, a native of Clarksville, TN, proudly calls Pensacola his true hometown, where he enjoys spending quality time his wife Khari, son Logan and daughter Madison.


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MDX Technology Reports Continued Expansion in 2015, Closes Funding Round
The software development company reported a record expansion in 2015 and successfully raised a USD seven-figure amount in funding.
Andy Traveller | Data ( FinTech ) | Thursday, 16/07/2015 | 14:11 GMT+2 2015-07-16T12:11:17+00:00 2015-07-16T12:11:17+00:00
Photo: Bloomberg
London-based software development company, MDX Technology Ltd (MDXT), announced that it has successfully completed a round of fund raising, which will further contribute to the expansion of its business.
Formed in 2010, the firm develops real-time market data collaboration solutions for the trading community, catering to traders, developers and market data professionals in the capital markets, energy and commodities sectors.
In the announcement, the firm recorded strong growth in 2015. MXDT confirmed with Finance Magnates that it now boasts 29 contracted clients, including investment banks, energy trading companies, proprietary traders, hedge funds, investment managers, spread betters, and software development companies.
"We have had five years of carefully managed organic development which yielded a variety of clients across all sectors and all regions," said Paul Watmough, CEO at MXDT. "The first half of 2015 has been exceptionally busy. During this we grew our existing client base, added several new name customers, extended our partner network and evolved our product offering to attract a wider audience."
The announcement also reported a successful completion of a first round of funding to accelerate further growth. In a statement to Finance Magnates, the firm confirmed that the investment was a seven figure USD raise: "The investors are pretty much all operating in the industry, some of which are existing clients and recognize the potential of the business."
David Priestley, Chairman at MDXT, said, "I was pleasantly surprised by the appetite to invest in MDXT. We were also very encouraged by the fact that a number of our existing clients were keen to participate in the fund raising."
dxFeed Upgrades Offering with 5th Generation of Market Data Platform
Liquidnet Expands into Provision of Investment Analytics
IPC Teams Up with OpenFin on Voice App Store, Collaborative Workflow


The best adventures in life aren't found on a map. The 2017 Toyota 4Runner brings over three decades of proven capability to your next adventure. 4Runner incorporates rugged body-on-frame construction and is equipped with skid plates to help protect the engine, front suspension and fuel tank (and the transfer case on 4x4 models). On the inside, a rugged, yet intuitive, interior trim and panel shape give you total control of 4Runner, so you've got freedom to roam. Outside and inside. Let's Go Places.
Wondering if the Toyota 4Runner is the Toyota for you? Here are a few ways in which the 2017 Toyota 4Runner TRD Off Road Premium compares against the 2017 Ford Explorer Limited 4WD. To start, Comparably Equipped Price on 4Runner TRD Off Road Premium 4X4 is $6,625 less than the Explorer Limited 4WD. 4Runner TRD Off Road Premium 4X4's Fuel Economy (city) is 17 while Explorer Limited 4WD's Fuel Economy (city) is 16. Looking to tow? 4Runner TRD Off Road Premium 4X4 has 3000 more pounds of Standard Towing Capacity than Explorer Limited 4WD, and Tow Package is Standard on 4Runner TRD Off Road Premium 4X4 but Optional on Explorer Limited 4WD. If cruising range is a concern, consider that The Cruising Range of the 4Runner TRD Off Road Premium 4X4 is 414 while it is 361 on the Explorer Limited 4WD.
These are just a few areas where the 4Runner outperforms the Explorer. Learn more in the chart below, or contact a dealer near you today!


Microsoft's newest version of its operating system, Windows 7, is finally in the release-to-manufacturing (RTM) stage, so the OS will soon be preloaded on new computers. Though not officially released yet, Windows 7 is expected to be a hit. For instance, after just eight hours on Amazon UK, Windows 7 pre-orders outpaced the total number of pre-orders for Vista over a period of 17 weeks.
According to Microsoft, Windows 7, which offers seven different versions of the OS, has undergone significant testing, quality assurance and validation required to get to the RTM stage. Independent software and hardware vendors will be able to download Windows 7 RTM as early as August 6th. Microsoft will be rolling out Windows 7 to other partners in mid to late August. Enterprise customers and developers will be able to download Windows 7 RTM in English starting on August 7, with additional language functionality for Windows 7 released shortly after.
For the plebes/consumers, Windows 7 will be in retail stores and shipping on new PCs starting October 22nd, which we already knew. After receiving an overwhelming response from beta testers, Microsoft is also offering a "family pack" for Windows 7 that will allow installation on up to 3 PCs. The company has also officially released the new version of Expression 3, the set of tools Microsoft offers for developers to build applications off of Silverlight.
Of course, the official RTM release of Windows 7 comes at a time when Microsoft's stranglehold of the operating system is being challenged by the recent announcement of Google's Chrome OS. Google is scheduled to release the open source code for Chrome OS later this year, which perhaps could conveniently fall around the October launch of Windows 7. The first Chrome OS computers won't launch until next year. While Google says the Chrome OS is targeted towards netbooks at the moment, there is definite potential for Google's OS to expand to the other types of computers, giving Microsoft something to mull over.


Turkish President Recep Tayyip Erdogan asserted on Tuesday that Turkey's infantry will participate in the liberation of Mosul, Iraq's second-largest city, from the Islamic State, despite repeated demands by Iraqi Prime Minister Haider al-Abadi that Turkey stay out of his country.
"The Turkish military will enter Mosul," Erdogan said Tuesday, after demanding Abadi stop publicly challenging him. Erdogan described Abadi's opposition to a Turkish presence in Iraq as "insulting" and dismissed Abadi himself as an inferior world leader.
"The Iraqi prime minister is insulting me, first know your limits. You are not my collocutor. Even you are not in my quality, my level," Erdoğan said, according to the pro-government Turkish newspaper Yeni Safak.
Abadi has repeatedly rejected the idea of Turkish help in the liberation of Mosul. "Turkish forces will not be allowed to participate in the liberation of Mosul under any circumstances," Abadi asserted on Sunday, protesting that Turkey had "violated Iraq's sovereignty" by placing troops inside its borders without Baghdad's approval.
Turkish Premier Binali Yildirim expressed concerns this week regarding the activities of other parties fighting in Iraq, particularly in regard to the reconstruction of Mosul. Mosul is currently the second-largest city in Islamic State control — after Raqqa, Syria, the Islamic State "capital" — and was traditionally home to diverse ethnic and religious groups.
In 2014, when the Islamic State took over, the jihadist group forced non-Sunni Muslims out of the city. Islamic State terrorists confiscated the property of all Christians, labeling it with the Arabic letter "N" for "Nazarene," and forced Christians to flee, convert to Islam and pay an "infidel's tax" (jizya), or face execution. Christians had been present in the city for two millennia, since Jesus's time.
Yildirim issued a statement warning that any alternation to the "demographic structure of Mosul after Daesh [ISIS] is taken out would spark a big civilian and sectarian war." Turkey's demographic concerns likely do not involve Christians, however, who have long fled Mosul, many living under Kurdish rule in northern Erbil.
Turkey has openly expressed alarm at the possibility of Syrian Kurdish forces establishing an independent Kurdistan out of Arab, Turkish, and Iranian territory. They would have to compete with the Iraqi military, led by a Shiite government and aided by Iran-backed Shiite militias. As those remaining in Mosul are Sunni Arab Muslims, a Shiite takeover could lead to sectarian violence.
Turkey deployed troops to Iraq in August, apparently to keep the Syrian Kurdish forces known as the YPG/YPJ from moving too far east in Iraq. "Operation Euphrates Shield" was nominally meant, however, to "clear Daesh [ISIS] from the southern border," according to Foreign Minister Mevlut Cavusoglu. That move alarmed Baghdad, and while the Iraqi Kurdistan Regional Government (KRG) accepts aid from Turkey, Sunni Kurdish leaders have denied that they have any information that Turkey will participate in the Mosul takeover.
"Turkey won't take part in the Mosul battle, they only train us. We will join with the Iraqi army, federal police and Peshmerga forces and will take part in the battle and expel ISIS from Mosul," Sunni General Mohammed Yahya, deputy commander of the Hashd al-Watani from Gudad military base in Bashiqa, told the Kurdish outlet Rudaw on Monday.
Rudaw notes that various sources have given them conflicting reports on whether Turkish troops in Bashiqa have attacked the Islamic State directly yet — Turkish sources say yes, while the Kurdish Peshmerga deny it.


Jamie Whincup topped Practice 2 for the ITM Auckland SuperSprint, as Supercars Championship leader Scott McLaughlin came unstuck.
Whincup took his Red Bull Holden Racing Team Commodore to a 1:02.6575s lap of Pukekohe, to finish 0.0962 seconds clear of David Reynolds.
McLaughlin, though, missed the bulk of the 40-minute session, which his title rival Shane van Gisbergen finished eighth.
After setting the pace on Friday morning, McLaughlin crashed at Turn 3, three minutes in.
Having set an initial flying lap, he locked a front brake in his Shell Ford between Turns 2 and 3 after landing on the kerb, firing into the outside tyres.
"Just trying to find a little bit more of a driving thing that I've been working on into there, I just overstepped the mark, completely my fault," McLaughlin said.
"Sorry to everyone at Shell V-Power Racing, I've given them a whole lot of work that they didn't need, I'll give myself a good kick up the arse and come back tomorrow.
"We've been locking into there all run, so I've been running a little bit more brake bias since the start of that session.
"I just lost the rear braking into 2 there, lost it and it was gone, passenger."
The session was red-flagged again inside the opening 10 minutes, when Andre Heimgartner's Nissan stopped at pit entry.
After an interrupted first half, Nick Percat led the way with a 1:03.2487s, 0.0098s clear of Scott Pye, followed by Whincup, Fabian Coulthard and van Gisbergen.
Percat's benchmark in the Coregas NZ Commodore stood into the final eight minutes, when running resumed after a third red-flag period.
Todd Hazelwood had fired off at Turn 1 in the Bigmate Racing Commodore but managed to wash off enough speed before getting to the tyre wall and avoided major damage.
Whincup jumped to the top with a 1:03.1316s straight after the restart but was quickly pipped by a 1:03.1316s for Tim Blanchard.
James Courtney, Rick Kelly and Reynolds had brief spells at the top in a frantic finish, before Whincup fired in the definitive 1:02.6575s.
"We had a programme, and we stuck to it," Whincup, in Triple Eight's prototype ZB this weekend, said.
"It wasn't that eventful for us. We just got through out plan, did our thing, and the car is pretty quick.
"I haven't driven this car before, so it took a bit of time to get used to it. But now it feels like home.
"We pride ourselves on engineering excellence, but you can just feel little differences here and there.
"Just positions of everything, how the steering rack reacts, how the car reacts over the bumps, the gearstick feels a bit different.
"And around this place you need to be at home, you need to be at one with the car.
"I was a bit timid at the start, because you can easily have big off here, but now I feel at home."
Reynolds wound up second, 0.0962s adrift, while Tickford pair Mark Winterbottom – in his penultimate event with the team – and Chaz Mostert leapt from 18th and 11th to third and fourth.
Pye and the lead Nissan of Kelly were next, ahead of top rookie Richie Stanaway in another Tickford Falcon.
Van Gisbergen was eighth, 0.3644s off the benchmark set by his team-mate, while Craig Lowndes and Tim Slade rounded out the top 10.
Courtney and Blanchard wound up 11th and 12th, and Percat 16th, after tagging the Turn 4 wall in the closing stages.
The Shell Fords of Coulthard and McLaughlin were 14th and 24th, with Heimgartner 20th and Hazelwood 26th.
The ITM Auckland SuperSprint continues on Saturday, with Practice 3 at 10:25am local time followed by ARMOR ALL Qualifying and the weekend's opening 70-lap race.


On most days we are answering your property questions for free via our Property Forum.
Q - I've found a property to buy that needs alot of work including structural work, I need a mortgage but each time I've been to a mortgage company, they've taken my money then told me that they will not give me the mortgage! What can I do?


About a 1 ½ hours north of Toronto is one of Canada's favorite hotels. With luxurious accommodation and gracious hospitality this hotel has won the hearts and minds of tourists and locals as Orillia's best accommodations. Whether you want a quiet and relaxing stay or a fun-filled retreat, Stone Gate Inn will not disappoint! – Casino Rama Shuttle Packages – Stay & Play Golf Getaway Packages – Live Theatre & Dining Escapes – Intimate Wedding Packages – Perfect Girls Getaway Retreat. It's no wonder why Stone Gate Inn is Orillia's #1 rated hotel. Don't miss us in the heart of Ontario's Lake Country! Certified "Bicycle-Friendly" by Ontario By Bike.


With the fiftieth anniversary of the May '68 upheaval weighing so heavily on the cultural hive mind at the moment, now's the perfect time for a retrospective of work by the radical director and producer of documentaries, Emile de Antonio. The Metrograph's is on through Monday, and at the New York theater's site, David Fresko looks back on "a series of double bills that would link his films with their fictional counterparts" that de Antonio dreamed up for a 1974 survey of his work. America Is Hard to See (1970), for example, "de Antonio's chronicle of Senator Eugene McCarthy's bid for the 1968 Democratic presidential nomination, was to be shown alongside Michael Ritchie's political satire The Candidate (1972)." Millhouse: A White Comedy (1971), about Richard Nixon, would be paired with Stanley Kubrick's Dr. Strangelove, or: How I Learned to Stop Worrying and Love the Bomb (1964). And so on.


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Themes from 'World News Tonight'
"World News Tonight" Current Theme
This World News Tonight theme is a composition by major Hollywood composer Hans Zimmer and his co-composer at Remote Control Productions Steve Mazzaro. They had previously worked together on the score for the Batman film "The Dark Knight Rises". This theme is a total departure from the theme that ABC's evening newscast had been using in some form or another since the late seventies. Although Zimmer has adapted his style for news music, the World News Tonight theme still sounds like a classic Hans Zimmer theme. He relies heavily on thumping, pulsating strings that evoke a sense of urgency, energy and determination. In musical terms it is called ostinato and in film scores it is often used to propel a scene forward which lacks dynamic visual action.
The result is a theme that sounds decidedly cinematic. It continues a trend of movie composers doing news themes that was started by NBC which commissioned John Williams in 1985 to compose The Mission. On Primetime Live movie composer Bill Conti composed the theme music. The theme debuted along with new graphics and a slightly refreshed set. ABC kept the theme when David Muir became anchor of the broadcast, though the open has been shortened.
Remote Control Productions - World News Tonight open Remote Control Productions - World News Tonight close
"World News Webcast" Theme
The webcast was launched in 2006 as part of a larger effort by ABC News to provide more frequent newscasts. When Elizabeth Vargas and Bob Woodruff started anchoring, they anchored 3 live broadcasts for 3 different timezones. And in the afternoon at 3 p.m. EST, one of them also did the daily webcast. In the beginning it was called World News Now, but the name was changed to avoid confusion with the ABC's overnight newscast. When Charlie Gibson took over as anchor, he continued the webcast but only appeared on it a couple of times a week. When Diane Sawyer took over World News in 2009, the webcast was cancelled.
The theme package for the webcast was originally intended for the weekend editions for World News Tonight.
Score Productions - World News Webcast
"World News Tonight" 2000 – 2012 theme
This is the version of the World News theme by Edd Kalehoff that was used in a period during which the broadcast underwent significant changes. Longtime anchor Peter Jennings passed away and one of his replacements, Bob Woodruff, was severely injured by a roadside bomb in Iraq. Eventually the other replacement for Jennings, Elizabeth Vargas, who was in effect sole anchor as Woodruff was out of the running, was replaced by Charles Gibson. He retired after three years as anchor of the program and was succeeded by Diane Sawyer. This theme is fifteen seconds shorter than the previous versions of the theme. Kalehoff compressed the front part, giving the theme a more urgent sound.
Edd Kalehoff - World News Tonight theme
Here's the headline bed that they used from 2000 to 2008.
Edd Kalehoff - World News Tonight 2000 - 2008 headline bed
In 2008 they started using a different headline bed that lasted for about a year. The program had dropped the 'Tonight' from its name, simply calling itself 'World News'.
Edd Kalehoff - World News 2008 - 2009 headline bed
And finally, this is the headline bed that ABC World News used from 2009 to 2012. It is derived from ABC's election theme at the time. The music composed by VideoHelper made its on air debut just a few months before Charles Gibson left the anchor chair.
VideoHelper - World News 2009 - 2012 headline bed
"World News Tonight" 2000 Open (Unused)
This theme was supposed to debut when World News Tonight premiered its new graphics in 2000. It didn't. While Peter Jennings, then-executive producer Paul Slavin, and others had cleared it, Senior Management had not. And that was a problem. At the very last minute, they decided that the show already had altered its appearance enough and that it might alienate viewers if it also changed it's long established theme. That's very unfortunate because it is a good theme. It's composed by the people at VideoHelper. The story, however, continues. Good Morning America later adopted this as their opening theme.
VideoHelper - World News Tonight theme (unused)
This theme was used on ABC World News Tonight with Peter Jennings until September 29, 2000 when they got brand new graphics. The theme was actually used on the weekend editions of World News Tonight until well into 2001 when that program got a graphics update as well. The music is essentially the same as the other versions with the exception that an extra "ta-dum" was added at the end. The primary difference is that this theme sounds louder. This is because the string instruments seem to have largely been replaced with more brass.
Here is the headline cue which is slightly different than the '89 version. Updates of the World News Tonight theme have, since 1998, been composed by New York-based composer Edd Kalehoff.
Edd Kalehoff - World News Tonight headline bed
For the first time since 1978, ABC News used a different theme for its evening flagship broadcast, World News Tonight. It was not entirely new because this theme is certainly based on the previous theme. It was used for a short period of time in which NBC Nightly News overtook ABC in the ratings. In 1998 they brought back a version of their original theme, but have in later years attempted twice (2000, 2001) to replace the original theme with something different. This short-lived theme was brought back for the coverage of the political conventions of 2000.
Edd Kalehoff - World News Tonight open
Edd Kalehoff - World News Tonight close
In 1990 the old theme was starting to sound dated, hence Score Productions produced an updated recording. The theme debuted without any new graphics and was probably not noticed by the average viewer. A bigger change to the opening sequence came a few years later. Up until 1994 World News Tonight started with the theme playing while a voice over introduced the anchor. But producers realized that a more effective way to get people to watch until the end is to tease the top stories at the top of the broadcast. So that is what they started doing. At first it lasted only a few seconds with the anchor just quickly mentioning their top stories. Later in the year it was expanded and accompanied by the music below. These days, the opening tease can last forty seconds or so.
Score Productions - World News Tonight theme Score Productions - World News Tonight headline bed
The 1978 theme music package is the first to contain the now famous ABC News signature. This is the orchestral update that was first used on World News Tonight in 1979. ABC News president Roone Arledge specifically wanted orchestral music to open the broadcast.
Arledge became president of the low rated ABC News in May of 1977 and would go on to create such programs as World News Tonight, 20/20, Nightline and later This Week with David Brinkley and PrimeTime Live. The first five years of WNT featured an anchor trio. Frank Reynolds (father of current CBS correspondent, Dean) was the lead anchor and based in Washington, D.C. Max Robinson, the first black network anchor, in Chicago anchored other national news. Finally, Peter Jennings in London anchored international news. With a year of its debut, the program made a remarkable leap in ratings when it passed NBC Nightly News with John Chancellor in the Nielsens. When Frank Reynolds died in 1983 of cancer, the program was relaunched with one anchor. After Dan Rather, Tom Brokaw, Roger Mudd and Ted Koppel passed on the job, it was given to Peter Jennings.
Score Productions - World News Tonight theme
Here's the version of the theme that was used on ABC News Radio up until 1995.
Score Productions - ABC News Radio theme
This is the teletype theme that was used at ABC News for various programs: Nightline, 20/20 and most famously, World News Tonight. In 1979 World News Tonight stopped using this theme as its main theme, but ABC used it until about 1996 for News Briefs. It's the first electronic news theme. Electronic music became popular in part thanks to the Moog Music, which released the first relatively affordable synthesizer in 1970. Before that time, most music was played by live instruments. Score Productions' Edd Kalehoff used the Moog Synthesizer for The Price Is Right theme which is still on the air today. They also used it for a number of other game show themes from that era. When ABC was looking for something different, Score Productions offered them a Moog-produced news theme. Though it did not stick around as long as the The Price Is Right theme, it certainly is an incredibly memorable theme.
"ABC News" 1975 – 1976 Theme
ABC first started a newscast in the fall of 1953. Its anchor was John Charles Daly and the broadcast lasted only 15 minutes, as was customary at the time. After many different anchors and other stunts (such as naming a young unknown man from Canada named Peter Jennings as anchor from 1965 – 1967), ratings still weren't great. From 1970 to 1975 Harry Reasoner and Howard K. Smith were at the helm of ABC News. The broadcast had no theme music, having a cold open and quiet close. In 1975 Smith was assigned a commentary role and Reasoner anchored solo. The broadcast was renamed "ABC News with Harry Reasoner". During this time, they used this theme, which is part of the KPM production music library and can be found on CD #433 but was originally found on vinyl 1138. The name of the piece is 'Gathering Crowds' and was also used on Fox's This Week in Baseball. On the air the theme sounded quite differently due to heavy editing, hence below you can listen to the original piece and how it was used on air. This theme was dropped in 1976 when Barbara Walters was named co-anchor of the renamed "ABC Evening News".
ABC News Open 1976
KPM Music - Gathering Crowds
"Peter Jennings with the News" Promo
Peter Jennings had two stints anchoring ABC's flagship newscast. In the 1960's ABC News was a distant third in the ratings, so the took a leap of faith and selected the young Canadian Jennings to compete with Walter Cronkite and the team of David Brinkley and Chet Huntley. But the public did not accept him. Too inexperienced and too unfamaliar with American culture. After just a few years, Jennings quit and became ABC's foreign correspondent. Here's a promo for Jennings' newscast. You might hear a piece of theme music in the background. That is the World News Now theme, which replayed this ad a few years ago.


Free Software and Open Source Software are not the same. Free Software does not mean it comes free of cost but to study and change the source code or design. You have heard that, lot of companies now arriving in a different avatar for commercial purpose. They are dangerously abusing the users' freedom, practically cheating with a subtitle like "Open Source Toothpaste Company". Today it is very important to understand the difference between Free Software and Open Source Software.
Free Software versus Open Source Software : Why We Need to Know the difference ?
We need to know the difference between Free Software and Open Source Software as today and in next few decades, computing will become an integral part of the life. You can shut down your computer or mobile phone, but many devices you actually can not shut down. Heath sector and medical devices are such examples.
To cite practical reason why we used the name Free Health Foundation NOT Open Source Health Foundation (Free Health Foundation has no relationship with Free Software Foundation except the idea of being free, the working spectrum is fully different), lies on the basic idea of what Richard Stallman actually defined by the word Free.
If Open Source Software was the same as Free Software; that "Toothpaste Company" would have used the subtitle "Free Toothpaste Company". Definitely I am not saying about Toothpaste but software related product or service. These Open Source company refuses or tries to avoid the moral ethics of defined by Free Software Foundation. There is practically no reason to use the phrase "Open Source" instead of "Free Software" except avoiding the legal and ethical points.
You will not nothing to disagree with if you sell a product by modifying it. Open source license for a particular thing needs to be read carefully by the user, whether it comes free of cost or is non-free. There is difference between non-free and commercial. Usually some legal points are modified. OpenStack project for example, is distributed under the Apache 2.0 license, which is Free Software and compatible under GNU GPL 3.0. But when a company uses it, usually they changes some parts of codes or terms of usage / License and it becomes Open Source. There are ethical flaws in OpenStack though. It requires Launchpad account, which actually is a point where Ubuntu collects the data. Ubuntu means Canonical Ltd. Canonical Ltd means all data is going to Amazon. Its funny, but logically the thing becoming is – Rackspace is encouraging to submit data to Amazon unknowingly (from the users' point).
This isthe basic reason, why it is far better to use own login system, that is different point though.
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Server OS and Desktop OS has differences. The same Operating System like Ubuntu is different on Server and on Desktop.Lets see Server OS and Desktop OS closely.
Cite this article as: Abhishek Ghosh, "Free Software versus Open Source Software," in The Customize Windows, April 7, 2013, April 21, 2019, https://thecustomizewindows.com/2013/04/free-software-versus-open-source-software/.


Imagine never having to use a key on your bike again and still having it secure. No more keys to rattle around and annoy you with sound or scratch up your perfectly polished machine...this is what the Motogadget m-Lock offers.
This simple system can utilize two options to turn your bike on and off. One is a very tiny, virtually invisible, glass vial (available for purchase separately here) that can be embedded into your jacket, gloves, or even helmet strap for a completely unencumbered experience. For a more straightforward approach, you can use the small plastic key fob about the size of a quarter that you simply swipe past the sensor and your bike comes to life, ready to go. It's almost like magic with no drama and no keys to carry ever again.
Depending on the model, key sizes range from very small (key fob sized) to tiny (glass vial) and may be integrated into other objects like gloves, clothing, pendants (non-metallic!), and more.
The m-Lock is a contact free digital ignition lock with Radio-Frequency Identification technology and substitutes mechanical ignition locks or a main on/off power switch for your motorcycle.
The associated digital key/transponder only has to be swiped near the m-Lock (switching distance approx. 1-2 inches) and the ignition is switched on or off completely contact free.
You simply must install the small m-Lock sensor somewhere on the bike and perhaps cover it with non-metallic parts like a plastic side panel or leather and this allows you to completely remove the mechanic ignition lock. This gives a very clean look and many design possibilities are guaranteed - especially for custom bikes! This can be the finishing touch to your machine. After all....this is how you actually turn the damn thing on!
The available option 'Glass Tube' is so small (3 x 13 mm) that it can be sewn into your gloves or clothing and really lose the key idea altogether. [Please note the reduced switching distance (about 5-10 mm) of the Glass Tube transponder] The 2 included standard keys (teardrop-shaped) are key fob-sized.
NOTE: We do not recommend using the m-Lock combined with immobilizers! Contact your dealer/manufacturer for information about the possible deactivation of the immobilizer if necessary.
For more documentation about the use and installation of the Motogadget m-Lock, we encourage you to consult the manual here.
Fantastic addition to the motogadget system.
The m-Lock is working great in conjunction with the m-Unit and m-Button. I'm doing a complete rebuild/modification of a '79 XS1100 and wanted to update the wiring. This setup allowed me to modernize the electronics and parts of the wiring harness in an uncomplicated way. I will absolutely use this system again.
After some research I found that this item needed a great deal more parts to get it working on my triumph. I'm not faulting revival cycles, but it would have been good information to have before getting in to it.
Order was quick and customer service was helpful during a short back order. Products arrived exactly as described and the M-Lock was exactly what I was hoping for, cleaned up my project nicely.
Works great, I would repurchase it for another bike and or classic car.
Works amazing with the motogadget M-unit. I don't do bike wiring (any wiring for that matter). I had two mechanics (who do wiring) turn the project down (complete wiring harness creation) - the combination Mi-unit & Wireless key made the project doable - and it works great! Even helps you know where you screwed up so you can fix it!
One of the coolest gadgets I've seen in a while. It was pretty easy to install and cleaned up the bike. I might buy these for every bike I build.
A pretty simple install as long as you are handy and have a basic knowledge of motorcycle electrics. Its super cool and everyone I show it to is amazed. I will be adding these to all my future bikes.
I have recently bought the m-unit,m-button,m-lock,harness,and a couple other things. I haven't had the chance to install everything yet. my scheduling has been a little backed up. Im really looking forward to doing this project. Im sure that I will be in touch with questions and your staff has been very helpful when I have needed it so far.


text:
package org.terasology.rendering.gui.framework.events;

import org.terasology.input.events.KeyEvent;
import org.terasology.rendering.gui.framework.UIDisplayElement;

/**
 *
 * @author Marcel Lehwald <marcel.lehwald@googlemail.com>
 *
 */
public interface KeyListener {
    void key(UIDisplayElement element, KeyEvent event);
}

redpajama_set_name: RedPajamaGithub


text:
La intolerancia a la proteína lisinúrica (IPL), también conocida como aminoaciduria dibásica de tipo 2 o aminoaciduria catiónica es un desorden metabólico autosómico recesivo que afecta al transporte de aminoácidos.
Se han reportado alrededor de 140 pacientes, aproximadamente la mitad de los cuales eran de origen finés. Asimismo, se han reportado algunos individuos afectos en Japón, Italia, Marruecos y el norte de África.

Características
La IPL se suele presentar tras el destete, pudiendo darse episodios diarreicos e incluso coma tras la ingesta de comidas ricas en proteínas, malnutrición, aversión a la comida rica en proteínas, hepatosplenomegalia, hipotonía muscular y retraso del crecimiento. Con el tiempo, pueden aparecer osteoporosis, afecciones pulmonares y renales, anormalidades hematológicas e incluso pancreatitis aguda.

Diagnóstico
El diagnóstico de la enfermedad puede establecerse mediante pruebas bioquímicas, como es la medida de la concentración de amonio en plasma, que suele ser elevada tras una comida rica en proteínas. Estas concentraciones plasmáticas de aminoácidos catiónicos, como son la ornitina, la arginina y la lisina, están por debajo de las normales para la edad, pero pueden encontrarse dentro de los parámetros normales. Por otro lado, las concentraciones de glicina, serina, prolina, alanina, glutamina y citrulina presentan un incremento frente a la concentración normal. Asimismo, la excreción de ácido orótico en la orina aumenta, al igual que la excreción de aminoácidos catiónicos, especialmente de la lisina. Otros compuestos que aparecen alterados en los niveles de plasma son la globulina fijadora de tiroxina (TBG), lactado deshidrogenasas (LDH) y ferritina, que aumentan. También es frecuente observar hipertrigliceridemia e hipercolesterolemia.
A nivel molecular, SLC7A7 es el único gen en el cual las mutaciones están asociadas a la enfermedad. Los tests moleculares identifican dos mutaciones que se observan en más del 95% de los individuos que presentan las alteraciones bioquímicas asociadas a IPL.

Diagnóstico clínico

El diagnóstico de la IPL se basa en hallazgos clínicos y bioquímicos y, recientemente, en los tests moleculares.
La LPI se suele presentar tras el destete o la alimentación con fórmula infantil, de forma variable y con cuadros clínicos no específicos que incluyen:
Vómitos recurrentes y episodios diarreicos
Episodios de estupor y coma tras comidas ricas en proteínas
Aversión a la comida rica en proteínas
Retraso del crecimiento
Hipotonía muscular
El diagnóstico de IPL no suele sospecharse por los hallazgos clínicos en sí mismo y puede pasar inadvertida durante la infancia a menos que halla implicaciones neurológicas que deriven en una evaluación diagnóstica que incluya la determinación de la concentración en sangre de amonio. En algunos casos, el diagnóstico se da en la edad adulta. Al cabo del tiempo, pueden descubrirse nuevas presentaciones clínicas como:
Escaso crecimiento
Osteoporosis temprana
Afecciones pulmonares subclínicas
Afecciones renales
Síndrome de linfohistiocitosis hemofagocítica o de activación macrofágica

Pruebas Bioquímicas
Individuos afectos
Concentración de amonio en el plasma, que suele ser elevada tras la ingesta de comidas ricas en proteínas. En ayuno, los valores son normales.
La excreción de ácido orótico en la orina es normalmente elevada.
Concentraciones de aminoácidos en plasma
Los aminoácidos catiónicos están por debajo de lo normal para la edad aunque pueden estar dentro de los parámetros normales.
Las concentraciones de prolina, alanina, glutamina, citrulina, glicina y serina son elevadas.
La excreción en la orina de aminoácidos suele estar incrementada, especialmente de la lisina.
Otros
Las concentraciones plasmáticas de TBG, LDH y ferritina son elevadas
Anemia normocrómica o hipocrómica, leucopenia y trombocitopenia son síntomas hematológicos no específicos
Suelen ser frecuentes hipertrigliceridemia e hipercolesterolemia.
Portadores.
Los análisis bioquímicos no pueden emplearse para determinar si un individuo es portador.

Pruebas genéticas moleculares
Actualmente, SLC7A7 es el único gen cuya mutación se sabe que causa IPL, de modo que las pruebas moleculares se realizan en torno a él. Algunas de las que se realizan son el análisis de secuencia, en el que se identifica el alelo causante; el análisis de la mutación diana y análisis de deleción/ duplicación, aunque este último se utiliza únicamente en investigación.

Tratamiento

De los síntomas
Crisis hiperamonemicas agudas: se recomienda la administración por vía intravenosa de cloruro de arginina y drogas como benzoato de sodio o fenilacetato de sodio para bloquear la producción de amonio, reducción del exceso de nitrógeno en la dieta y proporcionar energía en forma de carbohidratos para reducir el catabolismo.
A largo plazo: restricción de proteínas en la dieta, suplementación oral con citrulina y fármacos quelantes de nitrógeno, L-lisina-HCl y carnitina.

Prevención de las manifestaciones primarias
Se recomienda restricción proteica y administración de citrulina y fármacos quelantes de nitrógeno.

Prevención de las complicaciones secundarias
Vacunación contra la varicela en aquellos que no tengan historial previo de varicela o varicela zóster.

Seguimiento
Es necesario hacer seguimiento de las concentraciones plasmáticas de aminoácidos para identificar las deficiencias de los aminoácidos secundarios esenciales para la dieta de restricción proteica, así como las concentraciones de amonio en sangre durante el ayuno. Hay que prestar especial atención a signos de hiperamonemia y excreción de ácido orótico en la orina. Es recomendable evaluar la función renal periódicamente y la afección pulmonar.

Situaciones a evitar
Restricción proteica completa durante más de 24-48h.

Tests para los casos de riesgo
Pruebas genéticas moleculares o bioquímicas para el diagnóstico temprano y para tratamiento de familiares en riesgo.

Aminoácidos
Enfermedades raras
Enfermedades genéticas
Trastornos autosómicos recesivos

redpajama_set_name: RedPajamaWikipedia