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Pages tagged "Bars Restaurants and public places closed until May 1st"
Coronavirus In Minnesota: Gov. Walz Issues Executive Order Directing MN Residents To Stay At Home For 2 Weeks
MINNEAPOLIS (WCCO/AP) — Minnesota Gov. Tim Walz has issued an executive order directing Minnesotans to stay at home for two weeks in response to the coronavirus (COVID-19) pandemic Wednesday afternoon. Walz made the announcement in a 2 p.m. address from his residence, during a daily update on the pandemic with state health officials. The stay at home order goes into effect Friday night at 11:59 p.m. and is scheduled to end on April 10th.
Walz also announced that the closure of bars, restaurants and other public accommodations will be extended to May 1, 2020.


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BUILDING A NETWORK OF MUTUALITY: A CALL TO ACTION AND A FOUR-YEAR LOOK BACK
from Shanelle Matthews, Founder of RadComms
Dear RadComms: What a time to be alive! Every day, I am in awe of the incredible and unyielding commitment and work of movement-makers such as yourselves. Four years ago today, after Trump was elected, I asked social-justice communicators to join me in finding some way, small or large, for those of us who care about narrative power to ensure Trump doesn't get elected again.
One hundred of you joined the call the next day, and we decided we needed a network—so we built one and poured into it. Four years later, we have a new administration and a networked home for narrative power–builders to learn and grow together.
From those first 100 people to 3,500 members across platforms, the Radical Communicators Network has become a formidable movement home for discussion, engagement, and peer learning among communicators of 21st-century social movements. Since 2016, we have:Begun developing a theory of change for our network, which is unique in its centering of the grassrootsBuilt an impressive and democratized resource list
Hosted and recorded dozens of peer-learning sessions, teaching each other what we know about the ins and outs of strategic communications, media-making, narrative power–building, inclusion strategies, and storytelling
Organized a conference in 2017, bringing together a third of our membership to strengthen community-building and bonds across geographical and organizational lines (and thanks to a committed volunteer fundraising team, we have since raised the funds to organize another conference, which we look forward to sharing more about soon)Hosted dozens of happy hours in places like Portland, Los Angeles, Oakland, New York City, Gainesville, and Austin, to build community offline and meet our peers and co-conspirators face-to-face
Designated funding (among RadComms members within the philanthropic community) for us to author our first book, Building Narrative Power for 21st-Century Social Movements (working title), co-edited by myself and leadership team member Marzena ZukowskaPartnered with our co-conspirators and family at ReFrame to ensure we have adequate infrastructure to do our important work (THANK YOU!)
Earned a $100k grant, in collaboration with our partners at the Center for Public Interest Communications (CPIC), to co-create messaging direction with poor people about poor people and poverty that engenders an honest conversation about economic dignity for allCreated a space for white communicators to lean into racial solidarity, allyship, and deep vulnerability in our white accountability working group led by Anna Ghosh, Meredith Fenton, and so many others
Coordinated a beautiful mutual-aid effort that landed in the New York TimesAnd so much more
Together, we have shared in the pain and wretchedness caused by this outgoing oppressive regime, which has told story after story to malign and criminalize the most marginalized communities in this country, including immigrants, women, Black people (especially Black organizers), and people with disabilities, to name a few.
Together, we have contended with deeply entrenched narratives on every issue from climate to reproductive justice to immigration to police terror. We have fought tirelessly in the narrative realm for our ideas on inclusion, accountability, justice, and real democratic people power to become common sense. We have cultivated and told affirmative stories to build a world deserving of all of us.
Over the last two years, the inaugural Radical Communicators Network leadership team—including Ana Tellez, Marzena Zukowska, Hermelinda Cortes, Micky Jordan, Katrina Rogers, JD Davids, Bryce Fields, Chelsea Fuller, and me—began the long and tedious work of building stable, continual infrastructure for this community. As our terms come to an end, we are excited to bring on new leadership team members. If you're eager to step into leadership in this one-of-a-kind network, step forward and throw your hat in the ring.
Together, we've shared in the grief and unnecessary loss of more than a quarter-million people to the coronavirus and seen our daily lives shifted in vast ways. We leaned away from being with each other in person and leaned toward collective safety and healing so that we may be together again soon. And I hope we will.
This year, we also saw an incredible outpouring of politicized individuals (because of our organizing—let that soak in!) from every state stepping up to say Black lives matter, and it's time to divest from horrific and antiquated measures of policing and invest in a vision of public safety that works for all of us. If that is possible in America, anything is possible.
Because of the GOTV ground game of organizations that knocked on millions of doors, the people spoke and demanded a regime change. And that is what we got—exactly what we hoped for four years ago. And we played some small role in that. Congratulations and thank you.
Our work is not done. We know as organizers and movement-makers that the election of a new president does not negate our work, but that now we have a somewhat level playing field on which to contend for power. We owe it to ourselves, to this community that we have built over the last four years and invested in, to the relationships we have cultivated, to the victories we have won, and most importantly, to the people we serve, to deepen our rigor in this field and push this administration to radicalize, as well as question what is narratively and politically possible.
Thanks to each of you for joining in this experiment. We are a nimble network with low overhead, but we do have costs. If you have benefited in any way from the resources and community we have built together, can you chip in to help us pay for things like facilitation and stipends for under-resourced comms folks? Any amount is helpful. (You can also check out what RadComms members are saying about how RadComms has helped them expand the scope and possibilities fo thie rwork.
Whether you can give financially or not, we are so grateful that you are giving of your time and talents in the fight for narrative power, because what sets grassroots communicators apart is that we don't sacrifice principles or ethics for strategy.
We believe the most important role strategic communications plays in social movements is to build narrative power. We know stories and storytelling are the backbone of an inclusive society; how they are told defines whose lives are valued and whose are not. That is what makes our work so important. We also know narrative shifts and social change do not happen overnight—nor do they occur one organization at a time. They require all of us to be in community with one another. And here we are.
In community and service,
ShanelleP.S. You can also join us on Facebook and follow us on Instagram and LinkedIn.
RadComms Anthology
©2016–2022 Radical Communicators Network

redpajama_set_name: RedPajamaCommonCrawl


Easy-song-writing.com also provides software that can be used to write your own lyrics and music. Something similar to It's Official from SARAI.
:: The best It's Official midi files here!
SARAI - It's Official Lyrics and Midi files are provided by Easy-song-writing.com.


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Why intermittent fasting may be the best diet plan
http://ift.tt/2F1KJYm
Skipping meals to save calories is a sure-fire way to tank your metabolism and sabotage weight loss. Condense those food-free time periods to set intervals, however, and watch the fat melt away.
That's the principle behind the diet method known as intermittent fasting. Unlike many popular diets, intermittent fasting has the backing of scientific research (including a massive 2017 study analysis by the International Society of Sports Nutrition), which suggests that intermittent fasting is just as effective as daily calorie restriction—sometimes better—at improving body composition. Furthermore, intermittent fasting doesn't involve any calorie counting, and may suppress hunger better than traditional low-calorie diets.
Intermittent fasting really just means a period of eating followed by a period of not eating, repeated over time, explains Krista Varady, Ph.D., an associate professor of kinesiology and nutrition at the University of Illinois at Chicago, who has studied the effects of intermittent fasting on human body composition.
There are three types of intermittent fasting: whole-day fasting (5-6 feed days, 1-2 nonconsecutive fast days, repeated every week), alternate-day fasting (1 feed day, 1 fast day, repeated), and time-restricted feeding (4-8 feed hours, 16-20 feed hours, repeated daily).
All three types offer the same fat-burning benefits of intermittent fasting. The real differences are just in how long you're fasting and what you're allowed to eat during the fast, Varady says. On both whole-day fasting and alternate-day fasting, for example, you consume 500 calories per fast day to spark fat loss but maintain muscle. During time-restricted feeding, however, you're consuming zero calories during your fast period (water and tea, for example, are allowed). In all types, you're free to go hog-wild during the feeding window—though, obviously, all nutritionists would recommend you ditch the junk and stick to healthy fare.
About that: People don't usually binge that much on their feed day. "Most people report they can only eat about 10% more coming off a fast than they normally would—their body just won't let them overeat," Varady says. That's why an increasing number of studies show that intermittent fasting may work just as well as limiting your calorie intake when it comes to weight loss.
Now, intermittent fasting isn't magical—your calories still count. It's just an alternate way to reach that same calorie restriction, says Grant Tinsley, Ph.D., C.S.C.S., an intermittent fasting researcher and assistant professor of exercise physiology at Texas Tech University. "With traditional calorie restriction, you're following a normal, healthy eating pattern but eating less at each meal. With intermittent fasting, you're eating roughly the same number of reduced calories, just in a confined time frame. You're just giving yourself different parameters to live within."
What's the payoff of intermittent fasting?
The main benefit of intermittent fasting is weight loss—fat loss, specifically. "Insulin increases when you eat, and when insulin is high, you cannot burn fat. When you fast, insulin falls, which allows your body to access its stores of food (i.e., body fat) for energy," explains Jason Fung, M.D., a Toronto-based nephrologist and author of The Complete Guide to Fasting.
Study after study confirms that any form of intermittent fasting will help reduce weight and improve body composition, though the results are probably about the same as you'd see from restricting your calories. One study Varady ran, published in 2017 in JAMA Internal Medicine, found that after dieting for one year, people lost about 5–6% of their bodyweight whether they restricted their calories or tried alternate-day fasting.
Other studies suggest that intermittent fasting may help you lose more weight. One study in the Journal of Translational Medicine found that fit people who tried time-restricted feeding lost more fat and maintained more muscle than people who ate the same number of calories but over 12 hours instead of eight.
The science is mixed on which is better. What is confirmed, though, is that both methods work.
One advantage of intermittent fasting: helping you retain muscle mass. "When people lose weight, typically 75% is fat loss and 25% is muscle mass. But with fasting, the ratio actually changes so that 90% of weight loss is fat and 10% is muscle," Varady says.
And because you retain this muscle, your metabolism won't drop the way it might with calorie-restricted weight loss. In fact, fasting actually boosts your metabolism, says Tinsley. "There's a misconception that your metabolic rate will decrease if you're not eating. If you're fasting, your body views it as a mild stress, so research actually that shows your resting metabolism is actually higher after an overnight fast, and 16-24 hours is the window in which you see the largest increase in fat burn," he explains.
Plus, time-restricted feeding can help control cravings better than the normal, all-day graze, according to research out of the University of Alabama at Birmingham.
Additionally, alternate-day fasting and whole-day fasting have been shown to not only reduce body fat but also total cholesterol and triglycerides in both overweight and normal-weight people, according to a study analysis in Nutrition Reviews. Because intermittent fasting can stabilize insulin levels—if you don't eat, your blood sugar will come down—there's reason to believe it could be a good diet for people with Type 2 diabetes, Varady adds. Research also suggests that intermittent fasting may even help prevent Alzheimer's and cancer, adds Fung.
Intermittent fasting: What's the catch?
All three of our experts agree: There are no real downsides to intermittent fasting. "It's quite safe in terms of how it affects your health and biomarkers, and it doesn't lead to eating disorders," says Varady.
Fung concurs: "We, as physicians, tell people to fast all the time. Prior to surgery, prior to colonoscopy, for ultrasounds, even for fasting blood work, people need to fast and nothing bad happens. There's no more risk with extended fasting."
The biggest drawback is irritability—the first five fast days on alternate-day fasting and whole-day fasting are difficult for many people, Varady adds. "[Irritability] subsides after the first week or so, though, after which people actually say they have a boost of energy on their fast day," she adds.
Who should try it?
Intermittent fasting is safe for anyone to try. If you take medications, especially for diabetes, talk to your doctor first, Fung advises.
It's important to remember intermittent fasting is an eating plan, not a diet. "People certainly use it as a short-term plan to lean up and that's fine, but the majority of researchers prefer to think of it as a lifestyle you'd continue indefinitely as an alternate feeding plan," Tinsley adds.
That means there's certainly a type of person who won't fare as well on it. "If you're the type of person who wakes up ravenous, who loves breakfast, or who loves to snack, this may not be a good diet for you," says Tinsley. "You won't want to do something that makes it hard for you to adhere to. If this doesn't gel with something you enjoy, you don't need to fit yourself into this box just because intermittent fasting is popular right now."
Ultimately, if you're trying to lose fat or maintain a low body-fat percentage, the most important question is whether intermittent fasting is an easier day-to-day eating strategy than counting calories or focusing on macros, Tinsley says.
Ready to try intermittent fasting?
So: The first two weeks of intermittent fasting will suck. "Like anything else, fasting becomes easier the more you do it," Fung says. You'll likely experience side effects (lack of concentration, irritability, headaches, maybe constipation), and you may feel hungry, but you shouldn't feel weak, he adds. Learn how to cope with these and know that if you can power through the first 7-14 days, you're golden.
If you can't decide which strategy is best for you—whole-day fasting, alternate-day fasting, and time-restricted feeding—try each for a month, Varady advises.
Just remember: If you're trying whole-day or alternate-day fasting, your goal is to eat 500 calories on your fast day—and that's accounting for 50g of protein (200 calories' worth) to maintain muscle mass, she adds.
Again: Don't use your feed days as a free pass to the buffet. "During the feeding period, people should still stick to real, unprocessed foods and avoid sugar," Fung adds.
Wait, what about working out?
You can still work out on fast days, but stick to low-intensity work and try to get it in toward the start of your fast window rather than the end when your carb stores are totally depleted, Tinsley advises.
Also: Save your fast-day meal till after the workout, Varady adds. "In our studies, people got really hungry after they exercised, so a lot would cheat if they'd already eaten their 500 calories for the day," she explains.
Save high-intensity interval training and heavy weight training for feed days/during your feed window, if you can, when you have the calories for fuel and nutrients for recovery. But if your training schedule calls for a grueling workout on a fast day that can't be moved, add the calories burned to your count for the day so you don't burn through muscle. At 200 or 300 calories, you don't need to compensate, but if you burn 500 or more on a fast day, instead of just 500 maintenance calories with 50g of protein, eat 1,000 calories with 80g or more of protein, Varady advises.
via Men's Fitness http://ift.tt/2u0SmvI


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Related Post "List of Decorative Fencing Ideas"


if him & joker do a mixtape together it will be stupid.
would you prefer kano, demon & ghetto or east co vs kids in the hood??
Web have u got any Aftershock Sets wid Badness + Development?
Last edited by fuk off; 14th April '08 at 10:58 PM.
Ive got 2 Kano, Demon & Ghetto one's so im guessing we have same, East Connection set would be good, safe.


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Home | Shows | The Boys
2018-10-06 by Leave a Comment
Find out everything about The Boys right here on the The Boys TV show page!
Are you a fan of The Boys TV show? Do you think The Boys should be cancelled or renewed for another season? Stay tuned with the latest The Boys cancel/renew status and news.
Status: Running
Networks: Amazon, Amazon Prime Video
Originally Premiered: 2019-07-26
Seasons: 3
Genre(s): Action, Drama, Science Fiction, Superhero
The Boys Synopsis/Details:
Amazon Prime Video today announced that the hit superhero satire The Boys will premiere the first three episodes of its second season Friday, September 4, 2020. New episodes will be available each Friday culminating in an epic season finale on October 9. The news comes on the heels of the cast coming together for a virtual event, hosted by season two guest star Patton Oswalt, that looked back on season one and also dropped hints for the upcoming season. The eight-episode Amazon Original series will be available on Prime Video in more than 200 territories around the world, and is produced by Amazon Studios and Sony Pictures Television Studios with Point Grey Pictures, Kripke Enterprises and Original Film.
Today's streaming event also contained a sneak preview of the new season, with the cast and executive producer Eric Kripke revealing the opening moments of season two.
Creator and executive producer Eric Kripke says, "We cannot WAIT to show you season two. It's crazier, stranger, more intense, more emotional. In fact, it's too much - so the Surgeon General** has insisted we air the first three episodes on September 4, then air the remaining five episodes weekly after that. We wanted to give you time to freak out, digest, discuss, come down from the high, before we give you another dose. We only have your well-being in mind. Hope you love the season as much as we do.
**No, he didn't."
The even more intense, more insane season two finds The Boys on the run from the law, hunted by the Supes, and desperately trying to regroup and fight back against Vought. In hiding, Hughie (Jack Quaid), Mother's Milk (Laz Alonso), Frenchie (Tomer Capon) and Kimiko (Karen Fukuhara) try to adjust to a new normal, with Butcher (Karl Urban) nowhere to be found. Meanwhile, Starlight (Erin Moriarty) must navigate her place in The Seven as Homelander (Antony Starr) sets his sights on taking complete control. His power is threatened with the addition of Stormfront (Aya Cash), a social media-savvy new Supe, who has an agenda of her own. On top of that, the Supervillain threat takes center stage and makes waves as Vought seeks to capitalize on the nation's paranoia.
The Supes of The Seven also include Queen Maeve (Dominique McElligott), A-Train (Jessie T. Usher), The Deep (Chace Crawford) and Black Noir (Nathan Mitchell).
Recurring stars in season two include Claudia Doumit, Goran Visnijc, Malcolm Barrett, Colby Minifie, Shantel VanSanten, Cameron Crovetti, PJ Byrne, Laila Robbins and Giancarlo Esposito returning as Vought boss Stan Edgar, among others.
The Boys is a fun and irreverent take on what happens when superheroes - who are as popular as celebrities, as influential as politicians and as revered as Gods - abuse their superpowers rather than use them for good. It's the powerless against the super powerful as The Boys continue on a heroic quest to expose the truth about The Seven, and Vought - the multi-billion dollar conglomerate that manages these superheroes and covers up all of their dirty secrets.
Based on The New York Times best-selling comic by Garth Ennis and Darick Robertson, The Boys was developed by showrunner Eric Kripke (Supernatural), who also serves as writer and executive producer. Joining Kripke as executive producers are Point Grey Pictures' Seth Rogen (Preacher), Evan Goldberg (Preacher), and James Weaver (Preacher), Original Film's Neal H. Moritz (Prison Break) and Pavun Shetty (New Girl), as well as Phil Sgriccia, Craig Rosenberg, Rebecca Sonnenshine, Ken Levin and Jason Netter. Ennis and Robertson also co-executive produce along with Michael Saltzman.
The Boys TV show cancelled or season 3 renewed? The Boys TV series ratings? The cancellation reaper is stalking all the latest cancellation and renewal updates, so keep this page to hand to track The Boys Season 3 status and release date news.
Check out all related premiere dates for this show!
When Will The Boys Season 3 Release on Amazon? Renewal & Premiere Date
When Will The Boys Season 2 Start? Amazon Prime Video Premiere Date
The Boys Season 1 On Amazon Prime Video: Release Date (Series Premiere)
Find out more about The Boys at the following resources:
The Boys on IMDb
The Boys on Wikipedia
Review The Boys. Cancel reply
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Henry Clay Barnabee
Henry Clay Barnabee was born in Portsmouth, New Hampshire, in 1833, the son of a stage-driver turned innkeeper in Portsmouth. At the age of twenty, Barnabee moved to Boston, where he worked in the dry goods business while also pursuing acting and amateur singing. In 1859, he married Clara George of Portsmouth in Warner, New Hampshire, where her family originated. They made their home in Jamaica Plain, Massachusetts. In 1865, Barnabee made his formal performance debut and began touring New England with a concert troupe. In 1878, he joined the Boston Ideals, a group formed to present Gilbert and Sullivan's operetta, H.M.S Pinafore, though the Ideals would go on to perform other operettas. Barnabee and two other actors from the Boston Ideals formed the Bostonians in 1887. The latter group toured widely, making a number of transcontinental trips, until it finally disbanded in 1904. Its mainstay production was Smith and DeKoven's comic opera, Robin Hood, in which Barnabee played the role of the Sheriff of Nottingham. Clara George Barnabee died in 1906, the year in which Barnabee's career essentially ended. Henry Clay Barnabee published his autobiography, My Wanderings, in 1913 and died in 1917.
Version 1, edited by Nickajack on 23 January 2021, 11:40am


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Looking for info about University of Alaska ? Find articles and resources about career education, degrees and diplomas.
Associate Degree Programs
Doctorate Degree Programs
University of Alaska Review
University of Alaska is a public university made up of three campuses throughout Alaska, with the flagship school in Fairbanks. The main campus is made up of nine schools and students can choose from degrees and certificates in more than 100 disciplines.
University of Alaska Overview
University of Alaska is a land-, sea-, space- and sun-grant institution. It is home to more than seven major research units, including Alaska's Geophysical Institute and the Agricultural and Forestry Experiment Station. Since Fairbanks is located just 200 miles south of the Arctic Circle, students are in a unique position to study and research the Arctic. The school is most notable for its research in Arctic biology, engineering, geophysics and supercomputing. However, other academic disciplines include film, library science, forest sciences, education, biology, mining engineering and physics.
The Fairbanks campus of University of Alaska enrolls 8,575 students, but the greater University of Alaska system, with seven campuses around Alaska, educates more than 33,000 students a year.
Admissions and Enrollment Overview
To be admitted to University of Alaska, students must have received a high school diploma and transcripts or equivalent, taken the SAT or ACT and submitted a letter of intent. The school adheres to certain minimal standards in terms of grades and test scores, which are detailed on the school's website. Separate, detailed standards are required for first year students, whether they're home-schooled, international, transfer or a member of the military. Graduate applicants must have a bachelor's degree from an accredited institution. Depending on the field of study, different requirements may be in order.
Campus Facilities and Learning Environment
There are several book publishers at University of Alaska. These include the University of Alaska Press, the Alaska Native Language Center and the Alaska Sea Grant. There are also several magazines published on campus and two student newspapers, one of which is independent of the university. The university's fine arts complex houses student art shows, art galleries, BFA and thesis shows and combined faculty shows.
This school's athletic program competes at NCAA Division I for several sports, including hockey, for which it is best known. The team plays in downtown Fairbanks. University of Alaska's rifle team has also won ten NCAA National Rifle Championships since 1994.
Schools and Colleges at University of Alaska
College of Engineering and Mines
College of Natural Science and Mathematics
College of Rural and Community Development
School of Natural Resources and Agricultural Sciences
School of Fisheries and Ocean Sciences
Address: Signers' Hall, Fairbanks, AK 99775-748
www.educhoices.org
All other trademarks and copyrights are the property of their respective owners. All rights reserved.


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Home Research > Members > 1715-1754 > MANSEL, Hon. Bussy (?1701-50)
MANSEL, Hon. Bussy (?1701-50), of Briton Ferry, Glam.
Published in The History of Parliament: the House of Commons 1715-1754, ed. R. Sedgwick, 1970
CARDIFF BOROUGHS
31 Jan. 1727 - 1734
9 Mar. 1737 - 26 Nov. 1744
b. ?1701, 3rd s. of Thomas Mansel, M.P., 1st Baron Mansel of Margam, Glam. by Martha, da. and h. of Francis Millington of Newick Place, Suss.; bro. of Hon. Robert Mansel. educ. Ch. Ch. Oxf. 6 July 1717, aged 16. m. (1) 17 May 1724, Lady Elizabeth Hervey (d. 3 Sept. 1727), 1st da. of John Hervey, M.P., 1st Earl of Bristol, sis. of Carr and John, Lords Hervey, s.p.; (2) 13 Mar. 1729, Lady Barbara Blackett, o. da. of William Villiers, M.P., 2nd Earl of Jersey, wid. of Sir William Blackett, 2nd Bt., 1da. suc. to Briton Ferry on d. of kinsman, Thomas Mansel, M.P. 1706; bro. Christopher as 4th Baron 26 Nov. 1744.
The Mansel family had represented Glamorgan uninterruptedly from 1670 to 1712, when Bussy's father, Sir Thomas Mansel, was one of the twelve peers created to give a Tory majority in the House of Lords. After Lord Mansel's death in 1723, Bussy himself became a leading political figure in the county. In addition to his own estate of Briton Ferry, he managed the interest of his nephew, the 2nd Lord Mansel, until the latter came of age in 1740; and in 1738 he inherited a tenure for life of the Stradling estate of St. Donat's. Returned as a Tory on the family interest at a by-election for Cardiff in January 1727, he was again successful at the general election in that year, voting always with the Opposition. According to the 1st Lord Egmont he was the bearer, in April 1732, of a letter from his brother-in-law, Lord Hervey, to Anne Vane, the Prince of Wales's (and Hervey's) mistress, 'upbraid[ing] her with the ill services she did him with the Prince.' Miss Vane fell into a fit and threw the letter back to Mansel, who
swore to her he would be my Lord Hervey's death for making him the messenger of so great an affront, and for deceiving him, for that my Lord told him his letter was only to recommend a midwife. To prevent murder Miss Vane was obliged to acquaint the Prince with what happened, who made the matter up.1
In 1734 Mansel stood for the county but was narrowly defeated by William Talbot. On Talbot's succession to the peerage Mansel was not opposed at the ensuing by-election, retaining his seat until 1744 when he too became a peer. He continued to vote with the Opposition both before and after Walpole's fall but was one of those Tories who, on 13 Feb. 1741, voted for the Administration on the motion to dismiss Walpole. A man of miserly disposition, he was reputed to have left a large fortune at his death on 29 Nov. 1750.
Authors: Peter D.G. Thomas / R. S. Lea
1. HMC Egmont Diary, i. 264-5; Hervey, Mems. 482.


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Project acronym cis-CONTROL
Project Decoding and controlling cell-state switching: A bottom-up approach based on enhancer logic
Researcher (PI) Stein Luc AERTS
Host Institution (HI) VIB
Summary Cell-state switching in cancer allows cells to transition from a proliferative to an invasive and drug-resistant phenotype. This plasticity plays an important role in cancer progression and tumour heterogeneity. We have made a striking observation that cancer cells of different origin can switch to a common survival state. During this epigenomic reprogramming, cancer cells re-activate genomic enhancers from specific regulatory programs, such as wound repair and epithelial-to-mesenchymal transition. The goal of my project is to decipher the enhancer logic underlying this canalization effect towards a common survival state. We will then employ this new understanding of enhancer logic to engineer synthetic enhancers that are able to monitor and manipulate cell-state switching in real time. Furthermore, we will use enhancer models to identify cis-regulatory mutations that have an impact on cell-state switching and drug resistance. Such applications are currently hampered because there is a significant gap in our understanding of how enhancers work. To tackle this problem we will use a combination of in vivo massively parallel enhancer-reporter assays, single-cell genomics on microfluidic devices, computational modelling, and synthetic enhancer design. Using these approaches we will pursue the following aims: (1) to identify functional enhancers regulating cell-state switching by performing in vivo genetic screens in mice; (2) to elucidate the dynamic trajectories whereby cells of different cancer types switch to a common survival cell-state, at single-cell resolution; (3) to create synthetic enhancer circuits that specifically kill cancer cells undergoing cell-state switching. Our findings will have an impact on genome research, characterizing how cellular decision making is implemented by the cis-regulatory code; and on cancer research, employing enhancer logic in the context of cancer therapy.
Cell-state switching in cancer allows cells to transition from a proliferative to an invasive and drug-resistant phenotype. This plasticity plays an important role in cancer progression and tumour heterogeneity. We have made a striking observation that cancer cells of different origin can switch to a common survival state. During this epigenomic reprogramming, cancer cells re-activate genomic enhancers from specific regulatory programs, such as wound repair and epithelial-to-mesenchymal transition. The goal of my project is to decipher the enhancer logic underlying this canalization effect towards a common survival state. We will then employ this new understanding of enhancer logic to engineer synthetic enhancers that are able to monitor and manipulate cell-state switching in real time. Furthermore, we will use enhancer models to identify cis-regulatory mutations that have an impact on cell-state switching and drug resistance. Such applications are currently hampered because there is a significant gap in our understanding of how enhancers work. To tackle this problem we will use a combination of in vivo massively parallel enhancer-reporter assays, single-cell genomics on microfluidic devices, computational modelling, and synthetic enhancer design. Using these approaches we will pursue the following aims: (1) to identify functional enhancers regulating cell-state switching by performing in vivo genetic screens in mice; (2) to elucidate the dynamic trajectories whereby cells of different cancer types switch to a common survival cell-state, at single-cell resolution; (3) to create synthetic enhancer circuits that specifically kill cancer cells undergoing cell-state switching. Our findings will have an impact on genome research, characterizing how cellular decision making is implemented by the cis-regulatory code; and on cancer research, employing enhancer logic in the context of cancer therapy.
Project acronym DRY-2-DRY
Project Do droughts self-propagate and self-intensify?
Researcher (PI) Diego González Miralles
Summary Droughts cause agricultural loss, forest mortality and drinking water scarcity. Their predicted increase in recurrence and intensity poses serious threats to future global food security. Several historically unprecedented droughts have already occurred over the last decade in Europe, Australia and the USA. The cost of the ongoing Californian drought is estimated to be about US$3 billion. Still today, the knowledge of how droughts start and evolve remains limited, and so does the understanding of how climate change may affect them. Positive feedbacks from land have been suggested as critical for the occurrence of recent droughts: as rainfall deficits dry out soil and vegetation, the evaporation of land water is reduced, then the local air becomes too dry to yield rainfall, which further enhances drought conditions. Importantly, this is not just a 'local' feedback, as remote regions may rely on evaporated water transported by winds from the drought-affected region. Following this rationale, droughts self-propagate and self-intensify. However, a global capacity to observe these processes is lacking. Furthermore, climate and forecast models are immature when it comes to representing the influences of land on rainfall. Do climate models underestimate this land feedback? If so, future drought aggravation will be greater than currently expected. At the moment, this remains largely speculative, given the limited number of studies of these processes. I propose to use novel in situ and satellite records of soil moisture, evaporation and precipitation, in combination with new mechanistic models that can map water vapour trajectories and explore multi-dimensional feedbacks. DRY-2-DRY will not only advance our fundamental knowledge of the mechanisms triggering droughts, it will also provide independent evidence of the extent to which managing land cover can help 'dampen' drought events, and enable progress towards more accurate short-term and long-term drought forecasts.
Droughts cause agricultural loss, forest mortality and drinking water scarcity. Their predicted increase in recurrence and intensity poses serious threats to future global food security. Several historically unprecedented droughts have already occurred over the last decade in Europe, Australia and the USA. The cost of the ongoing Californian drought is estimated to be about US$3 billion. Still today, the knowledge of how droughts start and evolve remains limited, and so does the understanding of how climate change may affect them. Positive feedbacks from land have been suggested as critical for the occurrence of recent droughts: as rainfall deficits dry out soil and vegetation, the evaporation of land water is reduced, then the local air becomes too dry to yield rainfall, which further enhances drought conditions. Importantly, this is not just a 'local' feedback, as remote regions may rely on evaporated water transported by winds from the drought-affected region. Following this rationale, droughts self-propagate and self-intensify. However, a global capacity to observe these processes is lacking. Furthermore, climate and forecast models are immature when it comes to representing the influences of land on rainfall. Do climate models underestimate this land feedback? If so, future drought aggravation will be greater than currently expected. At the moment, this remains largely speculative, given the limited number of studies of these processes. I propose to use novel in situ and satellite records of soil moisture, evaporation and precipitation, in combination with new mechanistic models that can map water vapour trajectories and explore multi-dimensional feedbacks. DRY-2-DRY will not only advance our fundamental knowledge of the mechanisms triggering droughts, it will also provide independent evidence of the extent to which managing land cover can help 'dampen' drought events, and enable progress towards more accurate short-term and long-term drought forecasts.
Project acronym GENOMIS
Project Illuminating GENome Organization through integrated MIcroscopy and Sequencing
Researcher (PI) Marzena Magda BIENKO
Host Institution (HI) KAROLINSKA INSTITUTET
Summary In human cells, two meters of DNA sequence are compressed into a nucleus whose linear size is five orders of magnitude smaller. Deciphering how this amazing structural organization is achieved and how DNA functions can ensue in the environment of a cell's nucleus represent central questions for contemporary biology. Here, I embrace this challenge by establishing a comprehensive framework of microscopy and sequencing technologies coupled with advanced analytical approaches, aimed at addressing three fundamental highly-interconnected questions: 1) What are the design principles that govern DNA compaction? 2) How does genome structure vary between different cell types as well as among cells of the same type? 3) What is the link between genome structure and function? In preliminary experiments, we have devised a powerful method for Genomic loci Positioning by Sequencing (GPSeq) in fixed cells with optimally preserved nuclear morphology. In parallel, we are developing high-end microscopy tools for simultaneous localization of dozens of genomic locations at high resolution in thousands of single cells. We will obtain first-ever genome-wide maps of radial positioning of DNA loci in the nucleus, and combine them with available DNA contact probability maps in order to build 3D models of the human genome structure in different cell types. Using microscopy, we will visualize chromosomal shapes at unprecedented resolution, and use these rich datasets to discover general DNA folding principles. Finally, by combining high-resolution chromosome visualization with gene expression profiling in single cells, we will explore the link between DNA structure and function. Our study shall illuminate the design principles that dictate how genetic information is packed and read in the human nucleus, while providing a comprehensive repertoire of tools for studying genome organization.
In human cells, two meters of DNA sequence are compressed into a nucleus whose linear size is five orders of magnitude smaller. Deciphering how this amazing structural organization is achieved and how DNA functions can ensue in the environment of a cell's nucleus represent central questions for contemporary biology. Here, I embrace this challenge by establishing a comprehensive framework of microscopy and sequencing technologies coupled with advanced analytical approaches, aimed at addressing three fundamental highly-interconnected questions: 1) What are the design principles that govern DNA compaction? 2) How does genome structure vary between different cell types as well as among cells of the same type? 3) What is the link between genome structure and function? In preliminary experiments, we have devised a powerful method for Genomic loci Positioning by Sequencing (GPSeq) in fixed cells with optimally preserved nuclear morphology. In parallel, we are developing high-end microscopy tools for simultaneous localization of dozens of genomic locations at high resolution in thousands of single cells. We will obtain first-ever genome-wide maps of radial positioning of DNA loci in the nucleus, and combine them with available DNA contact probability maps in order to build 3D models of the human genome structure in different cell types. Using microscopy, we will visualize chromosomal shapes at unprecedented resolution, and use these rich datasets to discover general DNA folding principles. Finally, by combining high-resolution chromosome visualization with gene expression profiling in single cells, we will explore the link between DNA structure and function. Our study shall illuminate the design principles that dictate how genetic information is packed and read in the human nucleus, while providing a comprehensive repertoire of tools for studying genome organization.
Project acronym HOM
Project Homo Mimeticus: Theory and Criticism
Researcher (PI) Nidesh LAWTOO
Summary Mimesis is one of the most influential concepts in Western thought. Originally invoked to define humans as the "most imitative" creatures in classical antiquity, mimesis (imitation) has recently been at the centre of theoretical debates in the humanities, social sciences, and the neurosciences concerning the role of "mimicry," "identification," "contagion," and "mirror neurons" in the formation of subjectivity. And yet, despite the growing confirmations that imitation is constitutive of human behaviour, mimesis still tends to be confined to the sphere of realistic representation. The HOM project combines approaches that are usually split in different areas of disciplinary specialization to provide a correction to this tendency. Conceived as a trilogy situated at the crossroads between literary criticism, cinema studies, and critical theory, HOM's outcomes will result in two monographs and accompanying articles that explore the aesthetic, affective, and conceptual implications of the mimetic faculty. The first, radically reframes a major proponent of anti-mimetic aesthetics in modern literature, Oscar Wilde, by looking back to the classical foundations of theatrical mimesis that inform his corpus; the second considers the material effects of virtual simulation by looking ahead to new digital media via contemporary science-fiction films; and the third establishes an interdisciplinary dialogue between philosophical accounts of mimesis and recent discoveries in the neurosciences. Together, these new perspectives on homo mimeticus reconsider the aesthetic foundations of a major literary author, open up a new line of inquiry in film studies, and steer philosophical debates on mimesis in new interdisciplinary directions.
Mimesis is one of the most influential concepts in Western thought. Originally invoked to define humans as the "most imitative" creatures in classical antiquity, mimesis (imitation) has recently been at the centre of theoretical debates in the humanities, social sciences, and the neurosciences concerning the role of "mimicry," "identification," "contagion," and "mirror neurons" in the formation of subjectivity. And yet, despite the growing confirmations that imitation is constitutive of human behaviour, mimesis still tends to be confined to the sphere of realistic representation. The HOM project combines approaches that are usually split in different areas of disciplinary specialization to provide a correction to this tendency. Conceived as a trilogy situated at the crossroads between literary criticism, cinema studies, and critical theory, HOM's outcomes will result in two monographs and accompanying articles that explore the aesthetic, affective, and conceptual implications of the mimetic faculty. The first, radically reframes a major proponent of anti-mimetic aesthetics in modern literature, Oscar Wilde, by looking back to the classical foundations of theatrical mimesis that inform his corpus; the second considers the material effects of virtual simulation by looking ahead to new digital media via contemporary science-fiction films; and the third establishes an interdisciplinary dialogue between philosophical accounts of mimesis and recent discoveries in the neurosciences. Together, these new perspectives on homo mimeticus reconsider the aesthetic foundations of a major literary author, open up a new line of inquiry in film studies, and steer philosophical debates on mimesis in new interdisciplinary directions.
Project acronym MAGNETIC-SPEED-LIMIT
Project Understanding the speed limits of magnetism
Researcher (PI) Stefano BONETTI
Host Institution (HI) STOCKHOLMS UNIVERSITET
Summary While the origin of magnetic order in condensed matter is in the exchange and spin-orbit interactions, with time scales in the subpicosecond ranges, it has been long believed that magnetism could only be manipulated at nanosecond rates, exploiting dipolar interactions with external magnetic fields. However, in the past decade researchers have been able to observe ultrafast magnetic dynamics at its intrinsic time scales without the need for magnetic fields, thus revolutionising the view on the speed limits of magnetism. Despite many achievements in ultrafast magnetism, the understanding of the fundamental physics that allows for the ultrafast dissipation of angular momentum is still only partial, hampered by the lack of experimental techniques suited to fully explore these phenomena. However, the recent appearance of two new types of coherent radiation, single-cycle THz pulses and x-rays generated at free electron lasers (FELs), has provided researchers access to a whole new set of capabilities to tackle this challenge. This proposal suggests using these techniques to achieve an encompassing view of ultrafast magnetic dynamics in metallic ferromagnets, via the following three research objectives: (a) to reveal ultrafast dynamics driven by strong THz radiation in several magnetic systems using table-top femtosecond lasers; (b) to unravel the contribution of lattice dynamics to ultrafast demagnetization in different magnetic materials using the x-rays produced at FELs and (c) to directly image ultrafast spin currents by creating femtosecond movies with nanometre resolution. The proposed experiments are challenging and explore unchartered territories, but if successful, they will advance the understanding of the speed limits of magnetism, at the time scales of the exchange and spin-orbit interactions. They will also open up for future investigations of ultrafast magnetic phenomena in materials with large electronic correlations or spin-orbit coupling.
While the origin of magnetic order in condensed matter is in the exchange and spin-orbit interactions, with time scales in the subpicosecond ranges, it has been long believed that magnetism could only be manipulated at nanosecond rates, exploiting dipolar interactions with external magnetic fields. However, in the past decade researchers have been able to observe ultrafast magnetic dynamics at its intrinsic time scales without the need for magnetic fields, thus revolutionising the view on the speed limits of magnetism. Despite many achievements in ultrafast magnetism, the understanding of the fundamental physics that allows for the ultrafast dissipation of angular momentum is still only partial, hampered by the lack of experimental techniques suited to fully explore these phenomena. However, the recent appearance of two new types of coherent radiation, single-cycle THz pulses and x-rays generated at free electron lasers (FELs), has provided researchers access to a whole new set of capabilities to tackle this challenge. This proposal suggests using these techniques to achieve an encompassing view of ultrafast magnetic dynamics in metallic ferromagnets, via the following three research objectives: (a) to reveal ultrafast dynamics driven by strong THz radiation in several magnetic systems using table-top femtosecond lasers; (b) to unravel the contribution of lattice dynamics to ultrafast demagnetization in different magnetic materials using the x-rays produced at FELs and (c) to directly image ultrafast spin currents by creating femtosecond movies with nanometre resolution. The proposed experiments are challenging and explore unchartered territories, but if successful, they will advance the understanding of the speed limits of magnetism, at the time scales of the exchange and spin-orbit interactions. They will also open up for future investigations of ultrafast magnetic phenomena in materials with large electronic correlations or spin-orbit coupling.
Project acronym METLAKE
Project Predicting future methane fluxes from Northern lakes
Researcher (PI) DAVID TORBJORN EMANUEL BASTVIKEN
Host Institution (HI) LINKOPINGS UNIVERSITET
Summary The new global temperature goal calls for reliable quantification of present and future greenhouse gas (GHG) emissions, including climate feedbacks. Non-CO2 GHGs, with methane (CH4) being the most important, represent a large but highly uncertain component in global GHG budget. Lakes are among the largest natural sources of CH4 but our understanding of lake CH4 fluxes is rudimentary. Lake emissions are not yet routinely monitored, and coherent, spatially representative, long-term datasets are rare which hamper accurate flux estimates and predictions. METLAKE aims to improve our ability to quantify and predict lake CH4 emissions. Major goals include: (1) the development of robust validated predictive models suitable for use at the lake rich northern latitudes where large climate changes are anticipated in the near future, (2) the testing of the idea that appropriate consideration of spatiotemporal scaling can greatly facilitate generation of accurate yet simple predictive models, (3) to reveal and quantify detailed flux regulation patterns including spatiotemporal interactions and response times to environmental change, and (4) to pioneer novel use of sensor networks and near ground remote sensing with a new hyperspectral CH4 camera suitable for large-scale high resolution CH4 measurements. Extensive field work based on optimized state-of-the-art approaches will generate multi-scale and multi-system data, supplemented by experiments, and evaluated by data analyses and modelling approaches targeting effects of scaling on model performance. Altogether, METLAKE will advance our understanding of one of the largest natural CH4 sources, and provide us with systematic tools to predict future lake emissions. Such quantification of feedbacks on natural GHG emissions is required to move beyond state-of-the-art regarding global GHG budgets and to estimate the mitigation efforts needed to reach global climate goals.
The new global temperature goal calls for reliable quantification of present and future greenhouse gas (GHG) emissions, including climate feedbacks. Non-CO2 GHGs, with methane (CH4) being the most important, represent a large but highly uncertain component in global GHG budget. Lakes are among the largest natural sources of CH4 but our understanding of lake CH4 fluxes is rudimentary. Lake emissions are not yet routinely monitored, and coherent, spatially representative, long-term datasets are rare which hamper accurate flux estimates and predictions. METLAKE aims to improve our ability to quantify and predict lake CH4 emissions. Major goals include: (1) the development of robust validated predictive models suitable for use at the lake rich northern latitudes where large climate changes are anticipated in the near future, (2) the testing of the idea that appropriate consideration of spatiotemporal scaling can greatly facilitate generation of accurate yet simple predictive models, (3) to reveal and quantify detailed flux regulation patterns including spatiotemporal interactions and response times to environmental change, and (4) to pioneer novel use of sensor networks and near ground remote sensing with a new hyperspectral CH4 camera suitable for large-scale high resolution CH4 measurements. Extensive field work based on optimized state-of-the-art approaches will generate multi-scale and multi-system data, supplemented by experiments, and evaluated by data analyses and modelling approaches targeting effects of scaling on model performance. Altogether, METLAKE will advance our understanding of one of the largest natural CH4 sources, and provide us with systematic tools to predict future lake emissions. Such quantification of feedbacks on natural GHG emissions is required to move beyond state-of-the-art regarding global GHG budgets and to estimate the mitigation efforts needed to reach global climate goals.
Project acronym NARMESH
Project Narrating the Mesh: Ecology and the Non-Human in Contemporary Fiction and Oral Storytelling
Researcher (PI) Marco CARACCIOLO
Summary Today's ecological crisis prompts us to rethink our attitude towards physical and natural realities that have traditionally been seen as opposed to human subjectivity and agency. What emerges from this "non-human turn" is a sense of our interdependence on things like the bacteria in our intestines or the carbon atoms supporting life on Earth. Ecological theorist Timothy Morton uses the metaphor of the "mesh" to express this idea of human/non-human interconnectedness. This project will map the formal and thematic strategies through which contemporary narrative practices engage with the non-human and envisage this interconnectedness. Storytelling is an indispensable tool for making sense of experience by establishing temporal and causal relations. But it is also biased towards the human-scale realities of action and social interaction. How can narrative overcome this bias? How does it convey phenomena that challenge our belief in the ontological and material self-sufficiency of the human? Comparing fictional narratives in print (novels and short stories) and conversational storytelling, we will systematically explore the ways in which narrative can forge connections across levels of reality, weaving together the human and the non-human into a single plot. The assumption is that narrative is a field where fictional practices are in constant dialogue with the stories told in everyday conversation—and with the culture-wide beliefs and concerns those stories reflect. Through its three sub-projects, the proposed research charts this complex dialogue while greatly advancing our understanding of how stories can be used to heighten people's awareness of the mesh and its significance. The project builds on a combination of methods (close readings of novels, qualitative analysis of interviews), aiming to open up a new field of study at the intersection of literary scholarship and the social sciences—with narrative theory serving as a catalyst for the interdisciplinary exchange.
Today's ecological crisis prompts us to rethink our attitude towards physical and natural realities that have traditionally been seen as opposed to human subjectivity and agency. What emerges from this "non-human turn" is a sense of our interdependence on things like the bacteria in our intestines or the carbon atoms supporting life on Earth. Ecological theorist Timothy Morton uses the metaphor of the "mesh" to express this idea of human/non-human interconnectedness. This project will map the formal and thematic strategies through which contemporary narrative practices engage with the non-human and envisage this interconnectedness. Storytelling is an indispensable tool for making sense of experience by establishing temporal and causal relations. But it is also biased towards the human-scale realities of action and social interaction. How can narrative overcome this bias? How does it convey phenomena that challenge our belief in the ontological and material self-sufficiency of the human? Comparing fictional narratives in print (novels and short stories) and conversational storytelling, we will systematically explore the ways in which narrative can forge connections across levels of reality, weaving together the human and the non-human into a single plot. The assumption is that narrative is a field where fictional practices are in constant dialogue with the stories told in everyday conversation—and with the culture-wide beliefs and concerns those stories reflect. Through its three sub-projects, the proposed research charts this complex dialogue while greatly advancing our understanding of how stories can be used to heighten people's awareness of the mesh and its significance. The project builds on a combination of methods (close readings of novels, qualitative analysis of interviews), aiming to open up a new field of study at the intersection of literary scholarship and the social sciences—with narrative theory serving as a catalyst for the interdisciplinary exchange.
Project acronym PhilAnd
Project The origin and early development of philosophy in tenth-century al-Andalus: the impact of ill-defined materials and channels of transmission.
Researcher (PI) Godefroid DE CALLATAŸ
Summary The objective of PhilAnd is to conduct a large-scale exploration of how, and under which form, philosophy appeared for the first time in al-Andalus. This issue is pivotal to understanding the history of sciences and ideas, and the role of the Arab-Muslim world in this transfer to Medieval Europe. Its relevance today also lies in the fact that it addresses questions of cultural and religious identities, since the formative stage of philosophy in al-Andalus proved decisive in shaping the intellectual background of many later authors from the Peninsula, whether Muslims, Jews, or Christians. At the crossroads of major lines of enquiries in scholarship and in line with recent discoveries having important chronological implications, PhilAnd focuses on the 10th century, a period usually disregarded by historians on the assumption that philosophy as such was not cultivated in the Iberian Peninsula before the 11th-12th centuries. Its originality is also to put emphasis on 'ill-defined' materials and channels of transmission, a field which remains largely unexplored. This project consists of five topics designed for highly-specialised scholars, and of another three transversal types of exploration conducted in the form of conferences convened with leading experts in the world. The final objectives are to test the hypothesis: 1) that the emergence of philosophy in al-Andalus significantly predates the currently accepted time; and 2) that the impact of this formative stage was considerably wider than commonly acknowledged. This project also seeks to provide a better evaluation of the originality of the first Andalusī philosophers with respect to their Oriental forerunners. This cutting-edge investigation is likely to stimulate major changes in our perception of how this primeval stage of philosophy in al-Andalus determined the subsequent developments of rational speculation among the three monotheistic communities of the Peninsula and the intellectual formation of Europe.
The objective of PhilAnd is to conduct a large-scale exploration of how, and under which form, philosophy appeared for the first time in al-Andalus. This issue is pivotal to understanding the history of sciences and ideas, and the role of the Arab-Muslim world in this transfer to Medieval Europe. Its relevance today also lies in the fact that it addresses questions of cultural and religious identities, since the formative stage of philosophy in al-Andalus proved decisive in shaping the intellectual background of many later authors from the Peninsula, whether Muslims, Jews, or Christians. At the crossroads of major lines of enquiries in scholarship and in line with recent discoveries having important chronological implications, PhilAnd focuses on the 10th century, a period usually disregarded by historians on the assumption that philosophy as such was not cultivated in the Iberian Peninsula before the 11th-12th centuries. Its originality is also to put emphasis on 'ill-defined' materials and channels of transmission, a field which remains largely unexplored. This project consists of five topics designed for highly-specialised scholars, and of another three transversal types of exploration conducted in the form of conferences convened with leading experts in the world. The final objectives are to test the hypothesis: 1) that the emergence of philosophy in al-Andalus significantly predates the currently accepted time; and 2) that the impact of this formative stage was considerably wider than commonly acknowledged. This project also seeks to provide a better evaluation of the originality of the first Andalusī philosophers with respect to their Oriental forerunners. This cutting-edge investigation is likely to stimulate major changes in our perception of how this primeval stage of philosophy in al-Andalus determined the subsequent developments of rational speculation among the three monotheistic communities of the Peninsula and the intellectual formation of Europe.
Project acronym WeThaw
Project Mineral Weathering in Thawing Permafrost: Causes and Consequences
Researcher (PI) Sophie OPFERGELT
Summary Enhanced thawing of the permafrost in response to warming of the Earth's high latitude regions exposes previously frozen soil organic carbon (SOC) to microbial decomposition, liberating carbon to the atmosphere and creating a dangerous positive feedback on climate warming. Thawing the permafrost may also unlock a cascade of mineral weathering reactions. These will be accompanied by mineral nutrient release and generation of reactive surfaces which will influence plant growth, microbial SOC degradation and SOC stabilisation. Arguably, weathering is an important but hitherto neglected component for correctly assessing and predicting the permafrost carbon feedback. The goal of WeThaw is to provide the first comprehensive assessment of the mineral weathering response in permafrost regions subject to thawing. By addressing this crucial knowledge gap, WeThaw will significantly augment our capacity to develop models that can accurately predict the permafrost carbon feedback. Specifically, I will provide the first estimate of the permafrost's mineral element reservoir which is susceptible to rapidly respond to enhanced thawing, and I will assess the impact of thawing on the soil nutrient storage capacity. To determine the impact of increased mineral weathering on mineral nutrient availability in terrestrial and aquatic ecosystems in permafrost regions, the abiotic and biotic sources and processes controlling their uptake and release will be unraveled by combining novel geochemical techniques, involving the non-traditional silicon, magnesium and lithium stable isotopes, with soil mineral and physico-chemical characterisations. I posit that this groundbreaking approach has the potential to deliver unprecedented insights into mineral weathering dynamics in warming permafrost regions. This frontier research which crosses disciplinary boundaries is a mandatory step for being able to robustly explain the role of mineral weathering in modulating the permafrost carbon feedback.
Enhanced thawing of the permafrost in response to warming of the Earth's high latitude regions exposes previously frozen soil organic carbon (SOC) to microbial decomposition, liberating carbon to the atmosphere and creating a dangerous positive feedback on climate warming. Thawing the permafrost may also unlock a cascade of mineral weathering reactions. These will be accompanied by mineral nutrient release and generation of reactive surfaces which will influence plant growth, microbial SOC degradation and SOC stabilisation. Arguably, weathering is an important but hitherto neglected component for correctly assessing and predicting the permafrost carbon feedback. The goal of WeThaw is to provide the first comprehensive assessment of the mineral weathering response in permafrost regions subject to thawing. By addressing this crucial knowledge gap, WeThaw will significantly augment our capacity to develop models that can accurately predict the permafrost carbon feedback. Specifically, I will provide the first estimate of the permafrost's mineral element reservoir which is susceptible to rapidly respond to enhanced thawing, and I will assess the impact of thawing on the soil nutrient storage capacity. To determine the impact of increased mineral weathering on mineral nutrient availability in terrestrial and aquatic ecosystems in permafrost regions, the abiotic and biotic sources and processes controlling their uptake and release will be unraveled by combining novel geochemical techniques, involving the non-traditional silicon, magnesium and lithium stable isotopes, with soil mineral and physico-chemical characterisations. I posit that this groundbreaking approach has the potential to deliver unprecedented insights into mineral weathering dynamics in warming permafrost regions. This frontier research which crosses disciplinary boundaries is a mandatory step for being able to robustly explain the role of mineral weathering in modulating the permafrost carbon feedback.


m ⊥ n returns True if the integers m and n are relatively prime (that is, if gcd(m, n) = 1), and False otherwise.
v1 ⊥ v2 returns True if the n-dimensional vectors v1 and v2 are orthogonal w.r.t. the standard inner product of R^n (or E^n), that is if their scalar (dot) product (v1|v2) = v1⋅v2 vanishes.


Happy Monday everyone! Today marks the final day of the 2nd Annual Great Computer Spring Clean-a-thon which means it's time to share the progress you've made this week!
1) Clean out my Downloads, Documents and Current Projects folders. I set these up last year and have mostly kept them updated so they should only need a little work.
2) Reorganize my NettioDesigns folder. This folder is a hot mess right now. And not in a template-y goodness kind of way.
3) Get started organizing my photos in Aperture. This is a major major task and definitely not one I will complete this week but I am going to get started on it and see what I can get done. Started is better than nothing, right?
When I last updated you on my progress, I had completed the first 2 of my 3 Clean-a-thon goals, as well as a little extra credit digiscrap supplies purging.
So how did the rest of my week go?
Well…as much as it pains me to say it, I'm afraid I never did get to tackle goal number 3.
Because despite my best intentions, the universe had different plans for me and decided instead of spending my evenings happily purging photos while I watched my favorite reality TV shows, I should spend the week wallowing in my misery sick with the flu. Oh and just to add to the fun, I should wake up at 4am Wednesday morning with intense ear pain requiring a trip to urgent care and a round of antibiotics.
Believe me, I would have much rather been organizing photos.
But despite my initial disappointment, I've realized it's ok.
Because while I would have loved to come in here today with a big splashy photo-tastic update, the reality is that's not what the Great Computer Spring Clean-a-thon is about.
The goal of the Computer Spring Clean-a-thon is to kickstart your organizing progress, get you excited about organizing again and maybe even help you think about organizing in a different way.
And I definitely feel like I've done that.
So while I may not have tackled everything I hoped this week, I'm still feeling good about my progress. For the first time in a long time I'm feeling excited about the prospect of organizing photos and I'm ready to move forward and keep working on my goals. And that IS what this week is all about.
So how about you? How did your Computer Spring Clean-a-thon week go? Did you make the progress you hoped? Did you run into any unexpected roadblocks?
I'd love to hear about the progress (or lack of progress) you've made this week!
I didn't make nearly the progress I had hoped. To be honest I just didn't have much time at home, but I still thought I would get more done. I got my desktop cleared, but I still have a September wallpaper 🙂 I did get my in-box purged as well. And the time & computer hog – I'm about 50% complete with uploading all of my 2011 pictures to Picasa. It's uploading the full resolution file so it has taken 3 days to do 10gb! At the end of the day, if my computer crashed this would be the thing I was the most upset to lose so I'm happy to have this push. I can't believe I didn't upload at all for the whole year!
LOL, I stopped using any desktop wallpapers with dates because I never change them out, haha. That's still some awesome progress though! Way to go!
Well, like you, I've got started, but not nearly as much as I would like. My sister was in town, so I was with her and her kids entire weekend. I guess, at least I had a better reason than you did. Hope you're feeling better now!
I do plan to delete bad photos and start the adding keywords to the photos. I do tag my digi stash minimum 5-10 minutes everyday, so I'm good with that part. I also clean out my Download folder as soon as the kit is downloaded. I miss the part about selecting the folder to download my kits when I moved to Mac from PC. So, I move the kit as soon as I can.
Yeah, I slept pretty much all day Friday and that finally got me on the mend. Guess my mom was right when she said I needed to rest or else I wouldn't get better, haha.
You've made some great progress though! I still need to get all my photos added into Aperture and then I plan to start deleting and key wording too. Deleting probably needs to be the priority as boring as it is, haha, since I need to free up space on my machine.
So all in all, this week was good in laying the groundwork for some serious organizing, and I love that I got to do that! 😀 Thanks, Lynnette!
Woohoo, awesome progress! You rocked this challenge.
Ooo, way to go! Yay for clearing off the list!
Woo Hoo!!! Just reclaimed 212 GB!!!! Just had to come back and tell you! That's just from deleting the iPhoto directory! 🙂 Now, off to delete bad/duplicate photos!
Wow, that's awesome! Crazy iPhoto!


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For Valentine's Day, Heather and I enjoyed a 6 course farm-to-table dinner at Roaring Creek Farm. Paul Schertz opens his farm house once or twice a month for these farm-to-table dinners. There's a waiting list, and when a spot opens up, it fills up within 15 minutes of sending out the email. We'd been wanting to go for months, but pregnancy and children and work had prevented us from doing much outside the homestead.
Life has been good since baby Levi was born in November. In fact, it's been better than ever. The business is going well and requires less work and stress to maintain. So after enjoying an excellent anniversary meal at Rolfe & Daughters just a few weeks prior, I was ready for another sumptuous meal we wouldn't have to cook and jumped on the opportunity to take Heather to our first Roaring Creek farm-to-table dinner.
We approached the house a little bashful at first because we were carrying baby Levi. Most people who sign up to pay good money for a great Valentine's dinner aren't hoping to hang out with a baby. But we met some really great people from the start and never worried about it again.
Our names were written on spoons where our seats were reserved. We sat with eight other people we'd never met before. And it was FUN. I mean, this was the best date night we've had in years. The conversation and food exceeded my expectations. The house was warm and Paul and Pat made everyone feel like a welcome member of the family. It was an experience worth repeating, for certain.
I am inspired by the lifestyle Paul and Pat are building within their community. They are living off the land. With the help of Michael (Paul's son), they are operating Joe Natural's Farmstore and Cafe. They are fostering community while turning the fruits of their labors into gourmet experiences via farm-to-table dinners. And they offer help and resources any time they sense a need.
May we all learn to be so gracious and useful in our communities.
First Course: Cheese plate featuring House made herbed cheese, hummus, and olive tapenade. The goat milk was provided by Dolly and Ruby, two of Roaring Creek Farm's Nubian dairy goats.
Second Course: Trio of baked wonton wrappers stuffed with a medley of avocado and salmon, tilapia ceviche, and farm fresh eggs with caviar.
Third Course: Traditional French Onion Soup featuring house made beef stock, sweet onions, and Gruyere cheese.
Fourth Course: Romaine lettuce accented by house made olive dressing, tomatoes, black olives, and Parmesan cheese.
Fifth Course: Grass Raised filet of beef tenderloin medallions atop a sourdough crouton and accented by a mushroom glaze. Smashed red potatoes featuring garlic and olive oil, topped with goat cheese creme fraiche. Spinach Souffle.
Chocolate Dream Pie: Rich dark chocolate and sweetened goat cheese atop a shortbread crust.
Strawberry Shortcake: Features fresh strawberries dusted in sugar atop a homemade biscuit and freshly whipped cream.
I'm going to go crazy if Joe Natural's doesn't open back up soon! Glad to hear the farm to table dinner was so great!
They're reopening in March. At least, that's the current plan.
I would love to take my sister there. If only she would move here to experience the blessed milk and honey.


Pune, India, February 1, 2019: Zensar, a leading digital solutions and technology services company that specializes in partnering with global organizations across industries on their Digital transformation journey, announced today it has been featured in Novarica's Market Navigator Report: Business Intelligence Solutions for Insurers 2018.
ZenAnalytica provides a full‐stack solution including extract, transform, and load (ETL) models, data warehouse, and BI content. Zensar asserts that ZenAnalytica is a big data‐enabled platform for end‐to‐end information management. The solution offers a blend of automation, process orchestration, and simple integration to deliver BI and analytics. ZenAnalytica' s business intelligence functions include presentation/reporting, standard predefined reports, an ad-hoc reporting tool, data mining and analytics, predefined insurance specific dashboards, as well as report scheduling and delivery capabilities.


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text:
Q: Issues running nightwatch + selenium on local docker pipelines I am having issues when running a simple nightwatch test file on my local Docker image. I am trying to figure out why selenium does not want to run the local tests. If anyone has figured this out, any help would be much appreciated. Thanks!
Here is my test file:

nw-example.test.js

module.exports = {
  'End-to-end all browsers' : function (browser) {
    browser
      .init('http://localhost:3000/')
      .setValue('#loginForm-username', '')
      .setValue('#loginForm-password', '')
      .pause(2000)
      .click('#loginForm-submit')
      .perform(function(done){
        console.log('Done testing')
        done()
      })
      .pause(3000)
      .assert.containsText('#app','Welcome,');
  }
};

Here is my nightwatch.json file:
{
  "src_folders" : ["tests"],
  "output_folder" : "reports",
  "custom_commands_path" : "",
  "custom_assertions_path" : "",
  "page_objects_path" : "",
  "globals_path" : "",

  "selenium" : {
    "start_process" : true,
    "server_path" : "",
    "log_path" : "",
    "port" : 4444,
    "cli_args" : {
      "webdriver.chrome.driver" : "./usr/local/bin/chromedriver",
      "webdriver.gecko.driver" : "./usr/local/bin/geckodriver",
      "webdriver.edge.driver" : "",
      "webdriver.safari.driver" : ""
    }
  },

  "test_settings" : {
    "default" : {
      "launch_url" : "http://localhost:3000",
      "selenium_port"  : 4444,
      "selenium_host"  : "localhost",
      "silent": true,
      "screenshots" : {
        "enabled" : false,
        "path" : ""
      },
      "desiredCapabilities": {
        "browserName" : "chrome",
        "javascriptEnabled" : true,
        "marionette" : true,
        "acceptSslCerts" : true
      }
    },

    "chrome" : {
      "desiredCapabilities": {
        "browserName": "chrome",
        "chromeOptions" : {
          "args" : ["headless", "--no-sandbox"]
        }
      }
    },

    "firefox" : {
      "desiredCapabilities": {
        "browserName": "firefox"
      }
    },

    "edge" : {
      "desiredCapabilities": {
        "browserName": "MicrosoftEdge"
      }
    },

    "safari" : {
      "desiredCapabilities": {
        "browserName": "safari",
        "javascriptEnabled": true
      }
    }
  }
}

And the errors I am getting:
root@2b755e5a6174:/vital-webapp/src/__tests__# nightwatch nw-example.test.js

[Nw Example Test] Test Suite
================================

Running:  End-to-end all browsers
20:13:49.642 INFO - Found handler: org.openqa.selenium.remote.server.commandhandler.BeginSession@2465e6e1
20:13:49.643 INFO - /session: Executing POST on /session (handler: BeginSession)
20:13:49.646 INFO - Capabilities are: Capabilities {acceptSslCerts: true, browserName: chrome, javascriptEnabled: true, marionette: true, name: Nw Example Test}
20:13:49.646 INFO - Capabilities {acceptSslCerts: true, browserName: chrome, javascriptEnabled: true, marionette: true, name: Nw Example Test} matched class org.openqa.selenium.remote.server.ServicedSession$Factory (provider: org.openqa.selenium.chrome.ChromeDriverService)
Starting ChromeDriver 2.35.528139 (47ead77cb35ad2a9a83248b292151462a66cd881) on port 4516
Only local connections are allowed.
20:13:59.737 WARN - timeout
java.net.SocketTimeoutException: timeout

A: The error says it all :
20:13:49.646 INFO - Capabilities are: Capabilities {acceptSslCerts: true, browserName: chrome, javascriptEnabled: true, marionette: true, name: Nw Example Test}
20:13:49.646 INFO - Capabilities {acceptSslCerts: true, browserName: chrome, javascriptEnabled: true, marionette: true, name: Nw Example Test} matched class org.openqa.selenium.remote.server.ServicedSession$Factory (provider: org.openqa.selenium.chrome.ChromeDriverService)
Starting ChromeDriver 2.35.528139 (47ead77cb35ad2a9a83248b292151462a66cd881) on port 4516
Only local connections are allowed.
20:13:59.737 WARN - timeout
java.net.SocketTimeoutException: timeout

While you configured ChromeDriver you have suplied the following  desiredCapabilities :
  "desiredCapabilities": {
    "browserName" : "chrome",
    "javascriptEnabled" : true,
    "marionette" : true,
    "acceptSslCerts" : true
  }

ChromeDriver have no such capability as "marionette" which is set to true.
Remove the capability "marionette" : true and execute your @Test

redpajama_set_name: RedPajamaStackExchange


Skip The Dump In Bedford NH!
Among the fastest growing communities, not just in New Hampshire, but all of America is Bedford, New Hampshire.
A recent report released in 2015 on residential and commercial settlement rates ranked Bedford among top 25 very best places to live in the U.S.
The result being that increasing numbers of businesses and families are choosing Bedford as their lifestyle destination.
Why such high ratings? Of course, there are many reasons why a family or business would want to settle in Bedford, however the most common reasons cited are the lovely environment and the plentiful resources available.
Fresh air, clean rivers, low crime, affordability and location are among the many reasons why Bedford is growing so quickly, with employment opportunities in numerous local businesses, from banks to hospitals and everything in between.
And not to neglect Mother Nature, Bedford sports some lovely and popular spots to visit, such as the Watertown West End and Zorvino Vineyards, a family owned ranch that is already highly respected for its award winning wine.
Other hot tourist spots include the Witch City Walking Tour, Gore Place, Mels Funway Park and Chuckster's Family Entertainment.
Of course, all of these great activity centers attract increasing population. And that means increasing need for trash pickup, trash disposal and recycling services too, for both residents and businesses.
Today's business family or business owner would understandably prefer to skip the trip to the dump each week and let someone do it for them.
This is where SNH Disposal steps in to provide efficient, friendly and affordable garbage collection and disposal services.
• Keeping the environment clean. Rather than leave trash and disposables to pile, professional disposal guarantees that Bedford's waste recyclables are disposed of in an environmentally correct and timely manner.
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• Resources are utilized via trash recycling as common, everyday trash like cans and bottles are reused and natural resources preserved.
All of these factors and more are among the many ways that SNH Disposal can help keep Bedford, New Hampshire's environment clean.
Affordable rates, professional service and friendly staff are among the reasons to consider SNH Disposal as your trash pickup, disposal and recycling company for residential and commercial accounts in the Bedford and the greater Nashua, NH area.
Give us a call today at (603) 821-0146 for a friendly, free quote. You'll be glad you did!


You are about to enter a secure area of the site. This area holds final artwork files for all elements of the 2009 NextBuses campaign as well as logos and other generic graphic elements. You will be asked for a username and password after clicking the continue button below.
I don't have a username and password. How do I get one?
Usernames and passwords are available on request.
Click here to send an email request to Traveline.


text: turbo build --overwrite build.me "Wildcard Searches.sql" DATA

redpajama_set_name: RedPajamaGithub


Monique Griffith Designs: Totally Tees!
Super-Super cute! Wish I was local so I could take the class...I think it is going to be a BIG hit!
Would you consider me "local"? How cute is that, not quite as cute as Emily, but very cute.
I love it! I want to do that too! I am going to figure it out somehow!
I love those! Would you consider an online class? I would love to learn!
Those did turn out amazing! Great job.
Your little girl is so cute. And your blog is really nice...you have some great projects you've created.


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text:
DoubleTree By Hilton London ExCel
mary Kammitsi
ADNEC
Double Tree by Hilton ExCel
ADNEC Acquires DoubleTree By Hilton London ExCel
The Abu Dhabi National Exhibitions Company (ADNEC), part of ADQ, one of the region's largest holding companies, has added a new hotel to its portfolio: the DoubleTree By Hilton London ExCel.
The announcement comes in line with ADNEC's long term investment strategy, aimed at diversifying its business across the Group and achieving optimal integration of its assets through diversified economic sectors. The decision will further support both the UAE and British business and leisure tourism sectors, alongside the development of the local communities around the hotel, given ADNEC's extensive experience and capabilities across the hospitality industry.
The addition brings ADNEC's total portfolio of hotels to six, with other hotels under management including the Aloft Abu Dhabi, Andaz Capital Gate, Abu Dhabi, the Anantara Sir Bani Yas Island Abu Dhabi, and the Qasr Al Sarab Desert Resort by Anantara in the UAE. It also owns the Aloft London ExCel.
Humaid Matar Al Dhaheri, Group CEO, Abu Dhabi National Exhibitions Company, commented, "ADNEC is proud to welcome the DoubleTree By Hilton London ExCel to our portfolio. ADNEC holds a long-term investor perspective in identifying and acquiring key assets in developed markets. As such, this acquisition strengthens the Group's competitiveness, increases the direct and indirect economic contributions of the hotel and hospitality sector to the UK economy, and further enhances the business tourism sectors in both nations. This acquisition reinforces our commitment to sustain the development of local communities alongside bolstering the relationship between the public and private sector."
Strategic Asset Transfer for ADNEC Group
Mishaal Eid Appointed Hotel Manager of Franklin London
Tourism 365 Launches Business Trip to Promote Abu Dhabi
ADNEC Launches 'Tourism 365' to Support the Growth of Abu Dhabi