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CHANTEL JEFFRIES DROPS NEW SINGLE "BETTER"
Featuring Blocboy JB and Vory
Genre : Electronic
Date : Fri, 10 Aug 2018
DJ, producer and content creator Chantel Jeffries drops her latest track, "Better" ft. BlocBoy JB and Vory along with the accompany lyric video, via 10:22 pm/Capitol Records. The catchy track is the third track to be released off her upcoming album, Calculated Luck, after the first two have garnered nearly 35 million streams. "Better" features a blend of Hip-Hop and European House, solidifying Jeffries unique and undeniable sound.
Jeffries has also announced her collaboration with Quay Australia – Melbourne-based leading fashion eyewear company – as the face of their new blue light blocking clear lens glasses campaign. The campaign was shot in the music studio where she recorded "Better." The new single art features Chantel wearing her signature Quay Australia blue light frame, HINDSIGHT. The lenses feature technology to assist with blocking potentially harmful (blue) HEV light from digital screens. The blue light glasses collection—comprised of 7 styles—will be available August 8th online at ww.QuayAustralia.com and retailers worldwide for $60-$70 each.
Chantel's signature frame "HINDSIGHT": http://bit.ly/QuayHINDSIGHTBlueLight
After making her massive Las Vegas debut, Jeffries will return next weekend to DJ at Wet Republic and OMNIA marking the first live performances of her latest track, "Better." Links to purchase tickets and show dates can be found below, with more to be announced at a later date.
FRIDAY, AUGUST 17 AT WET REPUBLIC: TICKETS HERE
SATURDAY, AUGUST 18 AT OMNIA: TICKETS HERE
ABOUT CHANTEL JEFFRIES
Over the past few years, Chantel Jeffries has traveled all across the world as part of her whirlwind career as a DJ and content creator. In her constant globe-hopping, the 24-year-old has tapped into her infinite curiosity about music of all kinds, gaining a deep knowledge of everything from Euro-house to dancehall. Upon returning to L.A., Jeffries began channeling those inspirations into her burgeoning work as a producer—a process that finds the former math whiz using mathematical sequencing to create her artfully arranged tracks. The first taste of her hip-hop-infused take on dance music: "Wait," a bright and beat-heavy instant smash that quickly hit #4 on Billboard's Dance/Electronic Digital Song Sales chart, and has already amassed over 30 million streams worldwide.
Along with creating Calculated Luck, Jeffries has spent much of the past year DJ-ing major events like the Vanity Fair Oscar party and the Apple Music x Beats 1 party at Coachella. "The live set is a full experience, with a lot of visual stimulation in the lights and video elements," says Jeffries, who's now performing a series of summer DJ sets at legendary Las Vegas venues Wet Republic and OMNIA. Also a model and brand ambassador for the likes of L'Oreal, she's currently developing her own line of merchandise, to be released simultaneously with Calculated Luck later this year.
CHANTEL JEFFRIES RELEASES NEW SINGLE "FACTS"
CHANTEL JEFFRIES RELEASES NEW SINGLE AND VIDEO, "CHASE THE SUMMER" FT. JEREMIH


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Leeds Legacy Award Secures £200,000 For Mesothelioma Charity
Lawyers Secure Settlement Assisting Charity In Asbestos-Related Cancer Research
A Leeds based national charity dedicated to asbestos cancer research has outlined how legacy awards are supporting victims of mesothelioma and how £200,000 of additional funds will make vital new research possible into a disease that currently has no cure.
The June Hancock Mesothelioma Research Fund (JHMRF) is set to benefit from additional funds from the estate of Norman Rose, from Knaresborough, who died 65 on 27 April 2017 following a diagnosis of mesothelioma, a cancer of the pleural membrane surrounding the lungs which is associated with asbestos exposure.
Norman instructed asbestos related disease specialists in the Leeds office of Irwin Mitchell to investigate how he was exposed to asbestos, but sadly died before his case was concluded. His wife, Bernadette was devastated, and unexpectedly passed away on 28 June, 2017.
Following his terminal diagnosis, Norman also asked Irwin Mitchell to draw up a will for him and his wife that would leave their estate to the four charities closest to their heart and in addition to the JHMRF, included Mesothelioma UK, Macmillan Cancer Support and the British Liver Trust.
The settlement, together with the additional funds allows the JHMRF to continue supporting ground-breaking research initiatives in accordance with Norman and Bernadette's wishes. In February 2019, the JHMRF announced three new awards, one to study a rare variant of mesothelioma, another to promote patient involvement in research and a third targeting the development and progression of the disease.
The Rachel Dodds' Award was the Fund's first ever award for peritoneal mesothelioma. Led by Professor Marciniak and Dr Rassl at the University of Cambridge, the study will lay the foundation for future peritoneal mesothelioma research.
The pump-priming grant awarded to Dr Arber and Dr Marcu (University of Surrey) supports the development of research champions, promotes patient involvement in mesothelioma research and is helping to ensure patient priorities are considered when funding decisions are made.
A third grant in the charity's 2019 funding round was awarded to Dr Hansen at the University of Edinburgh to support his study of the Hippo Pathway and its potential to provide a new approach to treatment, by targeting the development and progression of mesothelioma.
"I got to know Norman and Bernadette well, so I know they would be delighted with the research the JHMRF is able to support as a result of their will. It means a lot to have played a role in making their wishes a reality.
"All too often in my role, I see the devastating impact of asbestos-related disease and while settlement awards of this nature are not common, the sums involved are making a big difference to ongoing research efforts aimed at beating this terrible disease."
Nicola Handley - Senior Associate Solicitor
Dr Kate Hill, Trustee of the June Hancock Mesothelioma Research Fund, said: "Thanks to the efforts of Irwin Mitchell, the substantial legacy provided by Mr and Mrs Rose is supporting vital research that will lead to better treatments and improved care for patients with mesothelioma.
"In a disease like mesothelioma, where little or no core research funding is available, legacies provide a sustainable source of funds to support vital research to improve treatment and care for mesothelioma patients. Sustainable funding enables the development of new ideas and allows emerging findings to be pursued in order to achieve breakthroughs that could help to save lives in the future.
"The research projects we have supported over the last 22 years, have only been possible thanks to the generosity of those who have donated to the Fund, raised money in memory of loved ones or people like Norman and Bernadette who remembered the Fund in their will. We appreciate every donation because every pound contributes to our mission to beat mesothelioma."
Action Mesothelioma Day 2020 will be marked despite the Covid-19 situation. The June Hancock Mesothelioma Research Fund will host their annual AMD Meet the Researchers Event online on Friday 3rd July 2020 from 1 pm to 3 pm. This event will provide patients and their families with an opportunity meet research groups from the Cambridge Institute of Medical Research and the Universities of Greenwich, Sheffield Hallam and Surrey.
Nicola Handley
Senior Associate Solicitor
+44 113 220 6233 +44 (0)113 220 6233 Email Nicola
Spencer Bailey
0114 274 7997 0114 274 7997 Email Spencer
Nicola HandleyAsbestos-Related DiseaseLeedsKnaresboroughAction Mesothelioma Day

redpajama_set_name: RedPajamaCommonCrawl


Engenium | Christchurch based consulting engineering company involved in structural and civil engineering, structural draughting and Tekla structures.
The team at Engenium has a proven history and commitment to our Clients, having worked together on and delivered, numerous high profile and complex projects throughout New Zealand.
The Engenium team has worked in close partnership with several Canterbury schools. A collaborative working approach produces intelligent engineering solutions and the successful delivery of projects.


Protein Structure Initiative:Biology (PSI:Biology) is the third phase of PSI where protein structures are determined in high-throughput to characterize their biological functions. The transition to the third phase entailed the formation of PSI:Biology Partnerships which are composed of structural genomics centers and biomedical science laboratories. We present a method to examine the impact of protein structures determined under the auspices of PSI:Biology by measuring their rates of annotations. The mean numbers of annotations per structure and per residue are examined. These are designed to provide measures of the amount of structure to function connections that can be leveraged from each structure.
One result is that PSI:Biology structures are found to have a higher rate of annotations than structures determined during the first two phases of PSI. A second result is that the subset of PSI:Biology structures determined through PSI:Biology Partnerships have a higher rate of annotations than those determined exclusive of those partnerships. Both results hold when the annotation rates are examined either at the level of the entire protein or for annotations that are known to fall at specific residues within the portion of the protein that has a determined structure.
We conclude that PSI:Biology determines structures that are estimated to have a higher degree of biomedical interest than those determined during the first two phases of PSI based on a broad array of biomedical annotations. For the PSI:Biology Partnerships, we see that there is an associated added value that represents part of the progress toward the goals of PSI:Biology. We interpret the added value to mean that team-based structural biology projects that utilize the expertise and technologies of structural genomics centers together with biological laboratories in the community are conducted in a synergistic manner. We show that the annotation rates can be used in conjunction with established metrics, i.e. the numbers of structures and impact of publication records, to monitor the progress of PSI:Biology towards its goals of examining structure to function connections of high biomedical relevance. The metric provides an objective means to quantify the overall impact of PSI:Biology as it uses biomedical annotations from external sources.
Protein Structure Initiative: Biology (PSI:Biology) determines the structures of proteins on a large scale to reveal their biological functions. Scientific partnerships (PSI:Biology Partnerships) are formed between scientists in the structural genomics centers and those in biological laboratories of the community. Through the work of the partnerships, broad and challenging biological questions are addressed . Example areas of study include metagenomics and microbiomes, whole genomes of organisms and organelles, and proteins along pathways as described by systems biology approaches. The technologies and expertise available in the structural genomics centers enable protein structures to be determined in high-throughput [2, 3].
Systematic approaches are utilized for structure determination through the PSI, and the methodological pipeline starts with the selection of protein targets [4, 5]. Summaries of the target selection processes are described in the Structural Biology Knowledgebase . One approach to target selection is to choose representative sequences from protein families. An example application of that approach is to obtain the structures of unique folds. That application has been demonstrated through the attainment of representative structures of proteins with unknown folds, as was done in the first two phases of PSI (PSI:1&2). The project is subsequently continued into the third phase of PSI, PSI:Biology.
The resultant structures of unique protein folds are used directly in further studies or they are leveraged to obtain homology models of proteins which have no known structure. Applications that are enabled include computational studies such as the interactions with ligands or drugs [7–9]. Computational studies to characterize the proteins are thereby supported by PSI. Follow-on experimental studies are supported through the provision of the DNA clones of the determined structures, as available through the Materials Repository .
There are a proportionate number of follow-on functional characterization studies that are performed by the broader scientific community after determination of protein structures by the PSI . But there is a latency in these functional characterization studies that reflects the natural pace at which these studies are undertaken and completed. With the entrance of PSI:Biology, there is now more participation of scientists from the biomedical community studying the functions of the structures. This is done in a coordinated manner and it is subject to the NIH peer-review process of partnership formation. The resultant PSI:Biology Partnerships direct structural projects from start to finish with regard to the selection of targets and the concurrent functional characterization studies.
The overall impact of the structural results of PSI for the biomedical community at large is monitored and assessed in part by accounting for the total number of structures determined. A corresponding online metrics site lists the resultant numbers of structures . For the structures determined through PSI:Biology, the user can examine the numbers of structures represented for different phyla and organisms, e.g. eukaryotic, prokaryotic, and human proteins. The metrics site also lists the number of PSI:Biology publications, citations, and total journal impact. These can also be used as measures of the biomedical importance of the research being done in PSI:Biology. These measures account for some of the information that is generated through the PSI. But summaries regarding the specific functions of the determined structures, as assessed by external biomedical resources, are necessary. These external measures provide a further understanding of the focus and depth of the structure to function relationships that have been characterized.
In the current study, we describe the biological relevance of the structures determined through PSI:Biology to estimate the relative impact that the project has for the elucidation of structure to function relationships. A protein here is viewed as having higher biological relevance if it has been studied to a greater extent by the biomedical community. The annotations used in the study are those that represent biological functions that can be attributed to more than one protein. The relative impact of PSI:Biology is quantified using the objective measures of the rates of annotation assignments made by biomedical resources that are external to PSI.
We utilize protein knowledgebases that comprehensively integrate and describe the broad array of biological functions of proteins. The UniProt knowledgebase is used, which characterizes protein sequences on the scales of all known proteomes [13, 14]. Also used are the functional annotations obtained through the Structural Biology Knowledgebase (SBKB) from sources external to PSI [6, 15]. These annotations and others from open sources described herein provide a perspective regarding the wide range of functions that are attributed to the determined protein structures.
To see the relative impact of PSI:Biology, we examine the average rates at which annotations are assigned to PSI:Biology structures relative to other structural projects. One comparison is for PSI:Biology relative to PSI:1&2. A second is for structures determined through the PSI:Biology Partnerships as compared to structures determined by US authors in which they do not participate in such partnerships.
For this comparison, we measure the impact of PSI:Biology relative to PSI:1&2 to see the differences in the trends of the annotation rates of structures. Figure 1 compares the potential impact of PSI:Biology structures with those coming from PSI:1&2. Specifically, we calculated the ratios of the mean number of assignments per structure for a range of annotations from multiple data sources. PSI:Biology structures are more highly annotated across most of the resources that describe functional and phenotypic associations. These results are statistically significant as judged by the Student's t-test (p-value ≤ 0.05). For example, PSI:Biology structures are relatively more highly annotated in the Orphanet resource, (p-value < 0.001), a resource that describes associations of proteins with rare disease . From the perspective of annotations assigned to particular residues within the structures, we also see that rates of PSI:Biology are higher than PSI:1&2. See Figure 2. These results support the assertion that PSI:Biology has focused on structure determinations of higher biomedical interest than those examined during PSI:1&2. See Additional file 1: Tables S1 and S2 for the data used in the plots.
Ratios of mean number of annotation assignments per protein from PSI:Biology versus PSI:1&2. A ratio greater than 1 indicates that on average there are more annotation assignments per protein structure from PSI:Biology than from PSI:1&2. Data for the plot is available in Additional file 1: Table S1. Inset- Ratios for a representative groups of annotations based on the UniProt keyword system.
Ratios of mean number of UniProt annotation assignments per residue from PSI:Biology versus PSI:1&2. The plot shows the ratios of the mean numbers of UniProt annotation assignments per residue for proteins addressed in all PSI:Biology projects versus all PSI:1&2 projects. Data for the plot is available in Additional file 1: Table S2. A ratio greater than 1 indicates that on average there are more assignments per residue for that annotation type in PSI:Biology as compared to PSI:1&2.
As assessed from the perspective of a broad spectrum of biomedical annotations shown, most annotation assignment rates are higher across PSI:Biology structures relative to PSI:1&2. The types of functions well represented in PSI:Biology tend to be those that are associated with higher order biological processes rather than molecular level functions. For example, we see that Gene Ontology biological processes and UniProt disease keyword annotations are greater for PSI:Biology, but the rate of Gene Ontology molecular functions is lower. We also see a greater percentage of mammalian and human source organism assignments when viewing the organism annotations for PSI:Biology relative to PSI:1&2. We infer that this higher representation of complex biology characterizes PSI:Biology.
The numbers of structures served as a metric for the first two phases of PSI, PSI:1 and PSI:2. It measured the progress toward the goals of these phases which included the development of methods for high-throughput structure determination and the determination protein structures that address different protein sequence families. The metric is applied for PSI:Biology where structures are determined in high throughput using the methods, coordination, and expertise developed during the first two phases. We see that the PSI:Biology numbers of structures metric describes the degree to which high throughput is sustained, but it does not address all the progress towards its goals of determining biomedically relevant structure to function connections. The inference is made based on the result that there are a greater number of annotation rates that are higher in PSI:Biology compared to PSI:1&2. To more fully address the progress, we introduce the annotation metric as a way to more fully capture the numbers of structure to function connections addressed in PSI:Biology. As applied, it is an objective metric since it utilizes annotations of function that are made by biomedical sources that are external to PSI.
The annotation metric assesses a broad range of functions and can be viewed as a complement to the established metric of counting the numbers of structures. Further, it is complementary to another established metric of the impact of PSI that is based on the corresponding publication records of the structures. These are described in the SBKB's publication portal . We see that the annotation metric can be considered in the context of the established metrics. For example, there are proteins that are biologically relevant that have yet to be studied to great extent by the scientific community, such as those developed through protein design . These proteins will have a low number of annotations yet they will maintain a relatively high biomedical relevance. A more optimal measure of impact for such structures may be based on their corresponding publication records. Also an additional measure of the rate of follow-on studies based on the structure is to be considered. One such measure has been developed to examine PSI-2 structures , and may continue to be applied to PSI:Biology structures. We see that the publication records, numbers of structures metric, and annotation metric provide complementary perspectives regarding the impact of PSI:Biology.
We next compare structures determined as a result of the PSI:Biology Partnerships to non-structural genomics structures determined by US authors available from the PDB (PDB US non-SG ensemble). There are 117 structures identified as resulting from PSI:Biology Partnerships, and 5613 structures are identified in the US non-SG ensemble. A stated goal in the composition of the PSI:Biology Partnerships is to determine protein structures that address broad, challenging biological questions [1, 6]. These projects are subject to the NIH peer-review process. The comparison set is the US non-SG ensemble, which represents all structures determined by US authors exclusive of structural genomics.
Figure 3 shows that the Partnership structures tend to have higher annotation rates than structures from the PDB US non-SG ensemble. For the comparison, we see that there is a focus on higher order biological processes and diseases. One illustrative example is a higher focus on signaling pathways related to human cancer, as exhibited in the representation of proteins in the National Cancer Institute's Pathway Interaction Database . A second illustrative example is a greater focus on coding sequence diversity, which includes complex annotations of splice variants . UniProt domains are also higher, which indicates a focus on biologically relevant domains. Noteworthy exceptions are enzymes, annotated with EC numbers, and relevant ligands, as suggested by BioCyc small molecule entries. We interpret this finding as a result of a selection bias against enzymes within the PSI:Biology Partnerships. See Additional file 1: Table S3 for data used in Figure 3.
Ratios of mean number of annotation assignments per protein from PSI:Biology Partnerships versus the PDB US non-SG ensemble. Asterisks indicate the annotation ratios that are statistically significant based on a Student's t-test (p-value ≤ 0.05). Data for the plot is available in Additional file 1: Table S3. Inset- Ratios for a group of annotations based on the UniProt keyword system.
There is a separate structural genomics initiative that focuses on enzymes , which was excluded from the US non-structural genomics PDB ensemble. Thus, there appears to be higher emphasis on biological relevance in PSI:Biology Partnership structures versus US, non-structural genomics structures in the PDB. We believe that most of the US, non-structural genomics structures in the PDB represent structures determined under the auspices of individual investigator funding mechanisms (i.e., primarily R01 funded structure determinations).
For the comparison between PSI:Biology Partnerships and the PDB subset, the mean number of annotation assignments for a representative group of annotation types based on the UniProt keyword system is also examined . See Figure 3, inset. These keywords address different types of functions of proteins and aid in the reduction of redundancy in the data. They also have the quality of being manually reviewed (those with UniProtKB/Swiss-Prot entries) or assigned by rules (those with UniProtKB/Tremble entries) . The UniProt keyword annotations were normalized according to their relative occurrence, and the average of the normalized annotation rates were used to estimate an overall degree to which a protein structure is annotated. This comparison indicates that there are approximately 30% more annotations per protein on average when comparing PSI Biology Partnership structures to the structures from the PDB US non-SG ensemble. Analyses of the average ratios and the normalized ratios indicate that they are statistically different between these groups. See Table 1.
The mean numbers of annotation assignments for the PDB US non-SG ensemble and the structures determined by PSI:Biology Partnerships are shown in the first two columns respectively. The third column shows the ratios of these means. The average of the eight ratios is calculated for an overall mean ratio. A 1-tailed unpaired t-test is performed to test the null hypothesis that the overall mean ratio is greater than 1 (p-value = 0.0317). In the fourth and fifth data columns, the normalized means are shown, where the normalization is done by dividing by the rates of annotation assignments by their corresponding means for the entire PDB for structures deposited during the relevant time frame (July 1, 2010 through February 28, 2013). A 1-tailed unpaired t-test is performed on the data sets to test the null hypothesis that the average of the means for PSI:Biology Partnership structures is greater than that for the PDB US non-SG ensemble (p-value = 0.0517).
We also see that the rates of the residue annotation assignments based on the UniProt system further support the finding that there is approximately a 1.3 times higher assignment rate for PSI:Biology Partnership structures relative to the PDB US non-SG ensemble. The residue assignments are based on UniProt's system of identifying sequence features. We view these residue level assignments as addressing different functions, and we see that they can be accumulated at the same scale to give an overall assignment rate per residue for each data set. See Figure 4 with the supplementary data provided in Additional file 1: Table S4. As a further test, we excluded the annotation types that we regarded as largely computational derived, e.g. Compositional bias, Transmembrane, Coiled coil, Domain, Repeat, Signal, and Zinc finger. The results show that annotation rates for the residue level assignments for PSI:Biology Partnerships are higher than for the PDB US non-SG ensemble, p-value = 2.9×10-30.
Ratios of rates of UniProt annotation assignments per residue for PSI:Biology Partnerships structures versus non-structural genomics structures in the PDB. Asterisks indicate the rates that are statistically different between the sets based on a Student's t-test (p-value ≤ 0.05). A ratio greater than 1 indicates that on average there are more assignments per residue for that annotation in structures from PSI:Biology Partnerships than from PDB US non-SG structures. Data for the plot is available in Additional file 1: Table S4.
The highest rate difference for the residue level assignments was for Transit peptide. That makes sense given that there is a Mitochondrial Protein Partnership that determines structures of associated with mitochondrion [1, 22]. Also prevalent are proteins that are alternatively spliced. Such proteins are seen as a relative focus given their importance in protein disorder , which is relevant to PSI:Biology projects that involve signaling networks . We see that further review of relative prevalence of the residue level annotations across the range of highly specific functions further reveals details of the relative focus of the PSI:Biology Partnerships.
There are two major findings from these analyses. First, PSI:Biology indeed has a higher focus on proteins documented as being biomedically relevant than PSI:1&2. This finding validates the annotation rate metric is a means to measure the impact of PSI:Biology with regard to the numbers of structure to biological function connections examined. The metric is complementary to established metrics of the numbers of structures and the corresponding publication record of the structures. Second, there is clear evidence that PSI:Biology Partnerships have determined structures that are found to have a higher biomedical relevance than that found for US generated, non-structural genomics structures. As more structures are determined through PSI:Biology Partnerships and more data is evaluated, we expect this trend to become more apparent based on the many annotation types analyzed.
An inference of the second finding is that PSI:Biology Partnerships provide an added value towards the goals of PSI:Biology with regard to the resultant biological relevance of the determined structures. We interpret the result as evidence that PSI:Biology Partnerships are focusing on the determination of protein structures for which there is a higher interest to the biomedical community as judged through the representative annotation types. These representative annotations are based on the UniProt keyword system and based on the system developed by UniProt to identify different residue level assignments of function. Through the elucidation of structures, we see the team-based PSI:Biology Partnerships as tying together the varied functional information of proteins that have high biomedical relevance.
We assess that the added value of the PSI:Biology Partnerships is something that has not previously been quantified, and represents some of the progress toward the goals of PSI:Biology. The NIH's implementation of peer-reviewed structural projects that involve the formation of well established collaborations between structural genomics centers and biomedical scientists in the community are seen as providing a viable means to achieve more valuable structures. We see that the annotation metric can be used to monitor the progress towards the goals of PSI:Biology. In particular we see the metric as a means to quantify the added value and benefits of the synergies realized through PSI:Biology Partnerships.
To facilitate access to the results of the PSI:Biology projects based on the annotation rates, a website with interactive charting is available . The site describes the datasets used in the study in interactive form, and it provides access to current updates of the annotations across all structures in the PDB. A corresponding weekly updated analysis of the annotation rates of PSI:Biology structures is available.
The first step in the data assembly was to review biomedical databases that annotate proteins and decide which annotations therein to use in the study. All resources were required to have an open-source policy of freely available information to the scientific community. We identified assignments of annotations that can pertain to more than one protein such that none of the assignments used were specific to a single protein. Different proteins are defined as having a different primary accession code in UniProt. Annotations from a specific resource or subcategory of a specific resource were grouped as annotation types. A list of 43 annotation types that were identified is given in Additional file 1: Table S5.
Assignments of annotations were mapped to protein structures based on UniProt accession code correspondences for each protein structural chain. Information provided through UniProt data files and the SBKB were utilized. In addition, information was directly extracted from BioCyc , HumanCyc, NCI pathway , INOH pathway , CellMap pathway, ChEBI ligand , RGD , MGI , and OMIM . We used from RGD disease ontology (rdo) and pathway (pw) information for rat, human, and mouse. The MGI database was used to obtain mammalian phenotype information for mouse proteins. Phenotype information was used from OMIM.
As a representative group of annotation types, we used eight UniProt keyword categories. These keywords were viewed as covering a wide variety of annotations while remaining relatively independent with respect to the information that they provide. The UniProt keyword category called developmental stage was not used due to the use of non-standardized text descriptions instead of keyword assignments in some cases, and due to the relative scarcity of these annotations. The keywords of technical terms were not used as these can refer to the experimental system in which the protein was studied rather than a functional attribute of a protein.
A refinement of the keyword system for our purpose was to substitute the corresponding GO terms for the three keyword categories in UniProt– biological process, molecular function, and cellular component. The UniProt keyword entries are made to be different and complementary to GO terms in many cases, but there are significant synonymous cross-references as reflected in the mapping files. The choice to use GO terms was primarily based on the fact that not only are GO terms annotated manually and electronically by a specialized group of UniProt curators, but also manually by approximately 36 supplemental external groups as part of the GO Consortium . We also see that GO annotations in UniProt are generally limited to specific terms at the lowest leaves of the GO hierarchy. This has been verified by UniProt staff through a personal communication. We rely also on mappings between GO terms and structures from the SIFTs project , which adds another layer of review for these annotations.
Assignments of annotations of residues were taken from sequence annotation features as provided through UniProt. For the purposes here, only those annotation assignments that described as naturally occurring functions were used. In total, 29 types of annotation assignments from the group sequence annotation features were obtained. A list of the types of annotations used can be found in Additional file 1: Table S6.
The residue specific annotations from UniProt were mapped to those residues that were found within the region with a determined structure, and annotations outside these regions were not considered further. Mapping was done by using the information in the UniProt flat files that describe the functions of each residue. The information on the residue number correspondences between the UniProt sequence files and the PDB coordinate files were provided through the SIFTs project . We used the mapping files see which annotations fell within the region of the protein with a determined structure.
Protein structures deposited to the PDB were separated into three discrete data sets for comparison – PSI:1&2, PSI:Biology, and PDB US non-SG. The PSI:1&2 set (5138 structures in total) combined all structures determined during the first 2 phases of the PSI. PSI:Biology (1017 structures in total) contained all structures considered part of the third phase of the PSI. Any structures from the PSI projects that had multiple projects attributed to them, for example due to being studied at different structural genomics centers, were assigned to their earliest associated project. This was done to eliminate mislabeling protein structures that were determined in either PSI:1 or PSI:2 but subsequently have had a functional assay performed on them during PSI:Biology.
The third data set, PDB US non-SG (5613 structures), was comprised of US-only structures in the PDB deposited during the PSI:Biology time period, excluding those determined by structural genomics programs. We defined a PSI:Biology time period as structures deposited to the PDB from July 1, 2010 through February 28, 2013. Structures in the PSI:Biology project were separated into subsets based on their target categories as described in the TargetTrack database [34, 35]. PSI:Biology Partnership structures were chosen as the subset of PSI:Biology for a comparison to the PDB US non-SG data set. Of the 1017 structures determined in PSI:Biology as a whole, there were 117 protein structures identified as resulting from PSI:Biology Partnerships.
Each protein structure was associated with a UniProt accession code using information from SIFTS (5). Chimeric proteins (those protein structures that are associated with more than one UniProt accession) were removed from the data sets. The number of unique UniProt accession codes for each data set was 4444, 790, 81, and 2624 for PSI:1&2, PSI:Biology, PSI:Biology Partnerships, and PDB US non-SG respectively.
The rate, or mean numbers, of annotations per protein structure for each data set were calculated. The sum of the number of unique annotations was divided by the number of associated unique UniProt accession codes. For the residue level annotation analyses, the total number of residues for each project was split into groups of 250 residues, which was the average length of all the structures studied. There were 3842 groups for PSI:1&2, 815 groups for PSI:Biology, 62 groups for PSI:Biology Partnerships, and 2947 groups for the PDB US non-SG ensemble. The rates per residue of each sequence feature for residue level annotations were calculated by dividing the number of instances found per each group of 250 residues by 250. The average across all the groups of 250 for each project was obtained.
The rates of annotation for the protein level assignments and the residue level assignments were compared between data sets. Student's t-tests were conducted to show which annotation types had significantly different values between the data sets. For the comparison between the set of PSI:Biology Partnership structures to the set of PDB US non-SG structures, the average of the mean ratios of the annotation rates at the protein level across the representative group of annotation types based on the UniProt keyword system were tested to be greater than 1. The t-statistic was calculated by t = (x' – 1) / SE where x' is the average of the means and SE is the associated standard error. The mean numbers of annotations per protein for the representative annotation types (UniProt keywords combined with GO terms as described above) were also normalized to the mean for the given category as obtained for the entire PDB over the time frame of PSI:Biology. That time frame was July 1, 2010 to February 28, 2013. A 1-tailed unpaired t-test with the null hypothesis that the average normalized values across the annotation types for the two groups of structures was conducted.
National Center Biotechnology Information clusters of proteins with similar sequences.
We thank the SBKB team at Rutgers University for sharing their databases that integrate functional annotations of protein structures and for critical review of the study. Wendy Tao provided support for database transfer. David Micallef provided information regarding the TargetTrack database. Margaret Gabanyi and Li Chen kindly provided the list of protein structures determined by US authors. We thank Sameer Velankar for support on the residue level mapping. Financial support was provided in part by a grant from the National Institute of General Medical Sciences [grant number 5U01 GM093324-02].
WM identified the annotations that were utilized. WM, PD, and EJ created the programs for the integration of annotations and performed the data analysis. WM conceived the project. PD and WM wrote the paper. All authors read and approved the final manuscript.


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text:
var Maple = require('../Maple');
var $ = require('jQuery');
var Lazy = require('Lazy');
var fs = require('fs');

var BOARD_WIDTH = 3;
var BOARD_HEIGHT = 3;

var ERROR_ALREADY_PLAYED = -1;
var ERROR_NOT_IN_DICTIONARY = -2;
var WORD_ACCEPTED = 1;

// Test -----------------------------------------------------------------------
var TestServer = Maple.Class(function(clientClass) {

    Maple.Server(this, clientClass, [
        'echo',
        'board',            // Initial board, like 4 4 M0S0B0R0K0E0N0L0E0S0O0V0A0Y0F0T0
        'gameUpdate',       // Broadcast for when someone makes a move
        'clientInfo',
        'move',
        'moveResponse',
        'gameOver'
    ]);

}, Maple.Server, {

    started: function() {
        this.log('Started');
        this._populateWordList();
        this._generateBoard(this._boardWidth, this._boardHeight);
        this._pointTotals = {};
    },

    update: function(t, tick) {
        if (tick % 500 === 0) {
            this.broadcast('echo', ['Server', tick, this.getRandom()]);
        }
    },

    stopped: function() {
        this.log('Stopped');
    },

    connected: function(client) {
        this.log('Client has connected:', client.id, client.isBinary);

        this._pointTotals[client._conn.clientId] = 0;
        this._serializePointTotals();

        client.send('clientInfo', [client._conn.clientId]);
        client.send('board', [this._boardWidth + ' ' + this._boardHeight + ' ' + this._serializedBoard, this._serializedPointTotals]);
    },

    message: function(client, type, tick, data) {
        this.log('New Message received:', client._conn.clientId, type, data);
        if (type === 'move' && data[0]) {
            var playerID = client._conn.clientId;
            var moveResult = this._makeClientMove(playerID, data[0]);

            client.send('moveResponse', [this._lastWordAttempted, moveResult]);

            switch (moveResult) {
                case WORD_ACCEPTED:
                    this.broadcast('gameUpdate', [playerID, this._lastWordPlayed, this._serializedBoard, this._serializedPointTotals]);
                    break;
                case ERROR_ALREADY_PLAYED:
                    break;
                case ERROR_NOT_IN_DICTIONARY:
                    break;
                default:
            }

            var winnerID = this._isGameOver();
            if (winnerID != 0) {
                this.broadcast('gameOver', [winnerID]);
            }

        }
    },

    requested: function(req, res) {
        this.log('HTTP Request');
    },

    disconnected: function(client) {
        this.log('Client has disconnected:', client.id);
    },

    _board: [],
    _boardWidth: BOARD_WIDTH,
    _boardHeight: BOARD_HEIGHT,
    _serializedBoard: '',
    _serializedPointTotals: '',
    _boardColors: [],

    _availableWords: [],
    _playedWords: [],
    _lastWordPlayed: '',
    _lastWordAttempted: '',
    _pointTotals: {},

    _serializeGame: function() {
        this._serializeBoard();
        this._serializePointTotals();
    },

    _serializeBoard: function() {
        var string = '';

        // for (y=0; y < this._boardHeight; y++) {
        //     string += this._board[y].join('');
        // }
        // for (i=1; i < this._boardHeight * this._boardWidth * 2; i += 2) {
        //     string[i] = '_'
        // }
        this._pointTotals = {0: 0};
        for (y=0; y < this._boardHeight; y++) {

            for (x=0; x < this._boardWidth; x++) {
                string += this._board[y][x];
                var clientID = this._boardColors[y][x];
                string += clientID;

                if (typeof this._pointTotals[clientID] != 'number')
                    this._pointTotals[clientID] = 0;
                this._pointTotals[clientID]++;
            }
        }

        this.log('Serialized: '+ string);

        this._serializedBoard = string;
    },

    _serializePointTotals: function() {
        var string = '';

        for (var clientID in this._pointTotals) {
            string += clientID + ':' + this._pointTotals[clientID] + ',';
        }
        string = string.substring(0, string.length-1);  // Kill that last comma

        this._serializedPointTotals = string;
    },

    _generateBoard: function(width, height) {

        var letters = [];
        var numVowels = Math.floor(Math.random()*4) + 4; // 4..8

        for (i=0; i < width*height - numVowels; i++) {
            letters.push(this._randomConsonant());
        }
        for (i=0; i < numVowels; i++) {
            letters.push(this._randomVowel());
        }

        // Shuffle
        letters.sort(function() { return 0.5 - Math.random();});

        this._board = [];

        for (y=0; y < height; y++) {
            this._board[y] = [];
            this._boardColors[y] = [];

            for (x=0; x < width; x++) {
                this._board[y][x] = letters.pop();
                this._boardColors[y][x] = 0;
            }
        }

        this.log(this._board);

        this._serializeBoard();
    },

    _randomLetter: function() {
        return String.fromCharCode(Math.floor(Math.random()*26 + 'A'.charCodeAt()));
    },
    _randomConsonant: function() {
        var letters = 'BCDFGHJKLMNPQRSTVWXYZTHNRDSF';
        return letters.charAt(Math.floor(Math.random()*letters.length));
    },
    _randomVowel: function() {
        var letters = 'AAEEIOU';
        return letters.charAt(Math.floor(Math.random()*letters.length));
    },

    _makeClientMove: function(clientID, letterIndexes) {
        letterIndexes = letterIndexes.split(',');

        this.log('letterIndexes: '+ letterIndexes);
        this.log('board: '+ this._serializedBoard);

        var letters = [];

        for (var i=0; i < letterIndexes.length; i++) {
            var boardIndex = letterIndexes[i];
            var y = Math.floor(boardIndex / this._boardWidth);
            var x = boardIndex % this._boardWidth;
            //this.log('['+ boardIndex +']: ['+ y +', '+ x +']');
            letters.push(this._board[y][x]);
        }

        this.log("Client just played: " + letters);

        word = letters.join('');
        this._lastWordAttempted = word;

        if (this._alreadyPlayedWord(word)) {
            this.log('Already played');
            return ERROR_ALREADY_PLAYED;
        }
        if (!this._wordInDictionary(word)) {
            this.log('Not in dictionary');
            return ERROR_NOT_IN_DICTIONARY;
        }

        this._lastWordPlayed = word;

        for (var i=0; i < letterIndexes.length; i++) {
            var boardIndex = letterIndexes[i];
            var y = Math.floor(boardIndex / this._boardWidth);
            var x = boardIndex % this._boardWidth;
            this._boardColors[y][x] = clientID;
        }

        this._playedWords.push(word);
        this.log(this._playedWords);

        this._serializeGame();

        return WORD_ACCEPTED;
    },

    _alreadyPlayedWord: function(word) {
        return ($.inArray(word, this._playedWords) != -1);
    },

    _wordInDictionary: function(word) {
        console.log('Searching for word: '+ word);
        if (this._availableWords.length == 0) {
            this.log("Empty wordlist");
            return false;
        }
        return ($.inArray(word.toLowerCase(), this._availableWords) != -1);
    },

    // Returns 0 or the ID of the winner. Expects serialized pointTotals.
    _isGameOver: function() {
        if (this._pointTotals[0] == 0) {
            // Game over. Find winner.
            var winnerID = 0;
            for (var i in this._serializedPointTotals) {
                if (this._serializedPointTotals[i] > this._serializedPointTotals[winnerID]) {
                    winnerID = i;
                }
            }
            return winnerID;
        }

        return 0;
    },

    _populateWordList: function() {
        var that = this;
        // this._availableWords = [];
        new Lazy(fs.createReadStream('lib/enable.txt'))
            .lines
            .forEach(function(line) {
                that._availableWords.push(line.toString().trim());
            })
            .join(function(a) {
                that.log('Read wordlist of '+ that._availableWords.length +' words.');
            });
    }

});

var TestClient = Maple.Class(function(server, conn, isBinary) {
    Maple.ServerClient(this, server, conn, isBinary );

}, Maple.ServerClient, {

    message: function(type, tick, data) {
        console.log('Client got message:', type, tick, data);
    }

});

var srv = new TestServer(TestClient);
srv.start({
    port: 80,
    logicRate: 100 // only update logic every 10 ticks
});

redpajama_set_name: RedPajamaGithub


I wanted to give you the great news that not only was I able to finish my marathon this weekend, I shattered my goal of making Boston Qualifying time by running a 3:19! Even more amazingly, I did not feel ANY pain in my foot. I am absolutely amazed at being able to go from limping with tendonitis three weeks ago, to having no pain whatsoever during the race. It still doesn't hurt, 30 hours later.
I came to see Dr. Je rry (my first experience with chiropractic care) while I was pregnant with my second son. Getting regular adjustments from Jerry made that pregnancy much more comfortable than the previous one.
I knew that seeking chiropractic care meant that I was taking good care of my body, and I felt the difference.
Toward the end of the pregnancy, I developed a series of unforeseen complications, which resulted in my son, Dean, being delivered unexpectedly at 35 weeks.
I had an unusually large amount of amniotic fluid and Dean was hardly moving in the womb at all. After what was the scariest month of my life, we clung by Dean's side in the NICU amidst all sorts of monitoring, tests, and visits by specialists, and we found out that Dean had Prader-Willi syndrome (PWS).
Like many babies with PWS, Dean had very low muscle tone. In Dean's case, his tone was so low and he was born so weak that he could not even move his head or his limbs a lot of the time. My heart broke seeing my baby boy struggle in this frail body.
We saw a huge team of specialists, and Dean received physical therapy through Early Intervention. These were all great, but Dean still was so weak and lifeless.
As soon as Dean was released from the NICU at 5 weeks old, I knew that I had to bring him to Dr. Jerry (truth be told, I considered smuggling Jerry into the hospital for adjustments while he was there!).
I brought him to Jerry and I think the first time I did, I just cried the whole time. He and Sandi were so gentle with me and I'm thankful they were there to support me too as I tried to figure out how to help my sweet little Dean.
Jerry put his hands on Dean's head and neck and I'll never forget… the tiniest adjustments from Jerry's hands and Dean came ALIVE. I mean truly, he moved his arms, legs, and head while lying on that table like he had never moved before!
In Jerry's hands I saw strength come into Dean's body. I saw that it affected him, and that healing of some kind was taking place.
I made sure to bring Dean as much as I could after that, each time so encouraged by how the adjustments brought life to him.
Unfortunately, we moved to another state shortly afterwards, so we could not continue seeing Dr. Jerry for our chiropractic care.
Dean is almost 2 now and is doing great. He still has many challenges, but I think back to those times with Dr. Jerry taking care of him and the hope that it brought to all of us.


New Delhi: The Minister of Communications Shri Manoj Sinha launched here Tarang Sanchar, a web portal for Information sharing on Mobile Towers and EMF Emission Compliances and said that it will go a long way in clearing the myths and misconceptions of public on mobile towers and emissions from them. He expressed the hope that the portal will empower common man to know at the convenience of a mouse click, about towers working in a particular locality and whether they are compliant to the EMF emission norms defined by the Government.
Shri Sinha said that the portal will allow users to get a tower or base station checked for radiation emission, for a fee of Rs 4,000. He said that mobile phone today has become an essential requirement for all including the poor in the remotest corner of the country and no one will be allowed to spread misconception about the harmful radiation from the towers to impede the growth of the country. Shri Sinha reiterated that there are over 25,000 studies by WHO in the last 30 years on the subject and there is no proof that EMF radiation has any harmful effect on human health. Brushing aside growing concerns over the emanating electromagnetic frequency (EMF) radiations from mobile towers, the Telecom Minister once again reminded that Indian norms had prescribed 10 times stricter limits for radiation emission in comparison to global standards. He said that more measures are being taken to penalise the erring entities.
Shri Sinha said that to realize the Prime Minister's vision of Digital India, it is necessary to have more and more mobile towers in every nook and corner of the country and the Ministry has already approved installation of towers over government buildings, 16 places in post offices and soon a decision will be taken to install the same in Cantonment Boards, which will not only help in spreading digital connectivity, but will also solve the problem of call drops significantly. Describing the launch of the portal a historic step, the Minister said that in future it will help in identifying the blind spots and added that it is also environment friendly as no paper work is required for this. He said that it has the complete collated technical details of over 14.5 lakh base stations (BTSs) spread across the country of all technologies (2G, 3G, 4G etc.) and of all Telecom Service Providers (TSPs).
Speaking on the occasion, Secretary, DoT Shri P K Pujari said that the portal will make information available to all concerned and he underlined that the focus of the government in the last three years has been transparency, disclosures and citizen-centric measures, which are the hall marks of good governance. He said, though there is no scientific evidence of any health concerns from low power mobile BTSs, a need was felt to educate the citizens about EMF emissions from mobile towers and status of their compliances. Shri Pujari said that the portal has three elements of providing information, EMF compliance process and interface between different departments, besides ease of doing business.
In his address, the Chairman, TRAI Shri R S Sharma said that the portal will be a mile stone for transparency, fair play, citizen empowerment and will finally lead to a knowledge economy. He said that digital empowerment in India is only possible when there is adequate digital infrastructure. Shri Sharma said that mobile phone in India today is not only a talking tool, but it has become an instrument for various transactions including cashless transaction and he lauded the collaborative effort between the government and the industry for this.
Shri G K Upadhyaya, Member (Technology) said that the EMF Portal is designed to provide a public interface where an easy map-based search feature has been provided for viewing the mobile towers in vicinity of any locality. He said the that any person can request for EMF emission measurement at a location by paying a nominal fee of Rs 4000/- online. The tests will be conducted by the local Telecom Enforcement Resource and Monitoring (TERM) filed unit of DoT and the test report will be provided to the requestor. The portal also has 'EMF Overview' and 'Learn' Sections, which provide numerous articles, booklets and videos, to further educate the citizens about EMF and coverage of telecom services. Shri R K Misra Member (Services) in Telecom Commission in his thanks giving address said that in addition to Government to Citizen (G2C) services, portal also facilitates Government to Business (G2B) service delivery in a transparent and eco-friendly manner.
Tarang Sanchar, a web Portal for Information sharing on Mobile Towers and EMF Emission Compliance - Department of Telecom (DoT), Shri Sinha said that the portal will allow users to get a tower or base station checked for radiation emission, for a fee of Rs 4,000.


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Sorry to send this as an "answer" but I'm at work and therefore blocked from the listerve. argh.
Anyway, I'm going to try to make the meeting this evening but I have a birthday drinks thing after work for a dear friend and it might be obnoxious for me to show up at the meeting half in the bag, so if that's the case I won't come.
There was a lot of interest on the Pratt listserve about RadRef, however a lot of grumbling that the meeting is on a Friday night (I guess lots of bartenders and waitresses aspiring to be librarians!) because they couldn't attend.
I also want to mention that Pratt is having a "librarian swarm" on Saturday October 3rd for Banned Books Week and the organizers wanted me to see if Radical Reference was interested in attending/swarming/etc.
Saturday, October 3 between 1 & 3 pm. @ Union Square.
If anyone is interested, you can contact Jessica directly.


Early childhood education gains become basically undetectable within a few years after children start elementary school. This has actually been known for a number of years, despite politicians touting early childhood education programs like Head Start and various pre-K programs, but I thought I'd bring it up now because it appears that Vox got the memo.
But, despite the lack of any learning advantage, kids in programs like Head Start do better later on in life. The answer seems simple, and something I've been saying for a long time. It's all just really expensive subsidized daycare. Of course, providing safe and healthy environments during a critical age is good for children, particularly poor and at risk children which Head Start focuses on. Not to mention, having the option of subsidized daycare is a boon to parents who can focus their daily attention on work and not have to give up a good chunk of their paycheck.
So what's the takeaway from all this? Basically, that we should kill early childhood education programs that don't do much and replace them with less learning intensive preschool and quality daycare. It'd be both cheaper and could help more families at the same time.
I would also suggest focusing more educational attention on shoring up middle and high school children. That's where they actually fall behind and get lost. Elementary schools are actually just fine. The reason why politicians like to focus on early-childhood education despite it being pretty worthless is because it's easier to start and expand programs than to make changes in the school system that already exists.
Eh, I think early childhood education is fantastic and if there is a program it should be used. I'd like to see more of a sorting where we go to school for say 8 years and get some learning like math, how to write and read and then based on some testing and choices of the kid you can either go on to a technical school to learn auto mechanics or a trade of some kind, service type stuff or you can go on to a further high school like education through a kind of voucher system that helps you prepare more for college where when you finally get to college you just learn what you need to become a master at it and not spend endless amounts of money taking useless dumb classes that are basically forced on you to make more money for the school. Less money spent on the dumb who will be doing menial work and more money spent on producing good scientists, lawyers, cpas and doctors.
But it's not. As far as education goes, it's basically tossing money down the toilet. Gains have been consistently found to be lost within a few years.
Daycare centers are required by law to provide quality activities for the children in their care. That usually translates to art activities, sensory playtime, story time, song circle, simple games that work on dexterity and memory and cooperation - all things that kids do in a traditional preschool. So, how would providing daycare over preschool save money, exactly? Keeping in mind that private daycare providers and public school teachers make generally the same salary, and use the same classroom/playroom equipment.
I read that Vox article last week, and my takeaway was that while Head Start didn't provide the initial intended outcome, the outcome it did provide more than justifies the program, including expanding it to serve more families. I also think that we should be learning from and emulating the French and Japanese preschool systems.
I am a subscriber to Piaget's Theory of Cognitive Development. It essentially states that children move through different levels of development up until adulthood. Ages 2-7 is the pre-operational stage. Children primarily learn through play and thought processes are concrete. Children can understand abstract ideas, such as numbers and letters, when tied to concrete concepts (children can understand five toys but not understand what the concept of five). Soft skills, such as socialization and structure, are much more valuable than hard academic skills (memorization of the alphabet or site words).
However, that is not to say that all instruction of literacy skills should be abandoned at the pre-K level. Students who have strong pre-literacy/ early literacy and number sense have a tremendous head start over their peers. Something that the article did not touch on (but a few of its sources did) was the importance of high quality primary teachers. Schools that serve highly impacted populations have a difficult time retaining high quality teachers. Head Start serves students that generally go to schools with high staff turnover and not as a high quality of teachers.
First, reading to your children doesn't have a huge impact on student achievement. What is important is that parents who read to their children value education. It is the household value on education that is important. Parents that value education but do not read to their children will likely have similarly achieving students than those that do read. Do students that enter K knowing their ABCs have more success because they know their ABCs or they come from an environment which views knowing ABCs are important?
Second, the Sesame Street Effect. Primarily in the 1970s and the 1980s, PBS was not available in all US homes. Access to PBS was not decided based on income, ethnic background, or home language. Research found that Sesame Street DID improve student literacy across the board. Similar to the Vox article, these literacy gains were lost after a few years. However, these gains were only lost in students from impacted backgrounds. Students from middle class backgrounds MAINTAINED these gains. Head Start serves students from impacted populations so it is likely they will have similar obstacles to maintaining those gains.
Third, research on pure play programs show that these students struggle with skills such as academic resiliency and conceptual change which causes a learning dip in the mid-primary years, primarily in third grade, when students switch from learning to read to reading to learn. So even though literacy skills may diminish in the Head Start program, there are many soft skills that are developed because of the literacy component. So even though the literacy skills may dip, there are other soft skills which are developed. Learning how to learn is more important than the learning itself.
I am not arguing that there isn't validity to reducing the literacy emphasis in pre-K programs, but we shouldn't throw the baby out with the bath water because the learning expectations are not aligned with expected results.
Daycare centers are required by law to provide quality activities for the children in their care. That usually translates to art activities, sensory playtime, story time, song circle, simple games that work on dexterity and memory and cooperation - all things that kids do in a traditional preschool.
I said "less learning intensive preschool and quality daycare". The question is more of the value of relatively intensive programs like Head Start and such that try to, well, give them a head start in school. I've got no issue with having plenty of positive activities like art, story time, and even some basic phonetics and math sprinkled throughout the day to keep the kids busy and give them a sense of structure. That's just good daycare and preschooling.
Also, there is no uniform law as you just described. Any daycare laws would be patchwork among states, but I've never heard of state that requires what you listed.
So, how would providing daycare over preschool save money, exactly? Keeping in mind that private daycare providers and public school teachers make generally the same salary, and use the same classroom/playroom equipment.
Programs like Head Start require teachers with higher levels of education. It requires more specific learning tools. It requires a stronger curriculum. It requires more oversight to make sure the program is being followed. All these things require a lot more money.
But the article is saying the same thing I have. The program Head Start doesn't do much. There's an easier, more cost-effective, way to get the same results that could be expanded to more families if we just ax the gold-plated program and instead provide what's actually important.
Third, research on pure play programs show that these students struggle with skills such as determination and conceptual change which causes a learning dip in the mid-primary years, primarily in third grade, when students switch from learning to read to reading to learn.
By all means, post the study.
I don't think I am. If I were trying to do that I'd just say to cut the programs. Instead I'm saying that programs like Head Start are luxuries we don't need when there are easier ways to get the same outcome.
This basically what I heard today on NPR.
It is not about the act of reading but actually causing a sense of security that helps you to better stretch boundries and learn more because you feel safe enough. You create a bond or something akin to being with a person who is willing to read those Golden Book Stories that shows your values to which a child can live up to. I'm tired so I can't write as cohesively but I work in a lower income school district and the turn over affects so much!
But I already pointed out that Iceheart's post was objectively incorrect.
I'm sure it does. However, again, what does this have to do with gold-plated educational programs like Head Start?
Besides, as I keep repeating, the real problem isn't elementary school anyway. Generally speaking, our elementary school system does a decent job. It's middle school and high school where things fall apart.
So why is it that we always look backwards to the one part of education that's not broken and keep trying to fix it?
I wasn't speaking universally, I was speaking from experience. I've worked home daycare, and my mom has worked both home and childcare center care. And your reading comprehension is off, I never said that states require all the things I listed as examples, I simply said that licensed daycares need to have a curriculum in place that focuses on learning and development, that looks a whole lot like a standard preschool class. To the point where daycare resources intended for the whole country outline activity curricula.
... that being said, I may have been confusing the Elder Care laws on activity participation in nursing and care facilities, which is another field I've worked in, with the child care laws.
The level of education a preschool teacher needs is not uniform across states. And regardless of education, you'll still probably only make $20K annually as a full-time employee of your local public school system, which I would hope they would offer to any full-time employee regardless of education status. Preschool does not require more specific learning tools or a stronger curriculum - look at any random child care center's curriculum page, and many flat-out call their 3-4 year old program "preschool." And even though some states do offer Head Start programs - not all - preschool is not a requirement in the US, so they'd just be subjected to whatever curriculum oversight the state requires of any school system if the states decide they do require it, and around here our Head Starts tend to partner with the public school systems anyway. And if you're a licensed child care facility in my state, you're subjected to frequent state inspections anyway, paid for by your tax dollars.
If you want to take it up with NPR, you can do so here.
Poe, do you mind if I ask what your skin in the game is here, beyond (I assume) being a taxpayer who votes on school millages? Spam and Ender are both teachers, so this issue directly impacts them, and they clearly have a lot of knowledge and experience backing up their replies. I have some personal experience in the daycare field from a provider's standpoint. Everyone has brought their receipts to this conversation so far but you, and yet you seem to have the strongest opinions about this.
From a certain point of view... if you're talking about the value of tax dollars being spent on head start programs and how to measure them it really depends on where you want your benchmarks to get results.
I have taken early childhood education classes and am working towards a masters in math ed where my focus is more middle school high school level but Ender who has much more teaching under his belt than me and a PhD pretty much covered what I think Icey was trying to say and expanded on it.
Personally I feel headstart programs serve a purpose within a community and are just as good as say enrolling your kid in Mom's Day out with the local Church where they learn "Bible" crafts and lore and get a meal/snack. One you pay out of pocket for the other comes from taxes.
Poe, do you mind if I ask what your skin in the game is here, beyond (I assume) being a taxpayer who votes on school millages?
I've been on a break, so didn't realize I had a direct question. I find appeals of authority to be self-defeating and much prefer others rate the worth of my position by the strength of my facts, interpretation, and how well I make them as opposed to whipping out credentials. But since you asked, I have about a decade in education under my belt and, though I've moved on, still maintain subbing privileges just for the fun of it. As it happens, I spent a long lunch break away from my regular job teaching a class today while the regular teacher did some training for a period.


text:
Métiers d'Art and Schools of excellence in ALMA
Saturday, October 11th, 2014, 11:00 a.m.
Reggia of Colorno
On Saturday, October 11th, 2014, on the occasion of the opening of the academic year, ALMA-La Scuola Internazionale di Cucina Italiana hostes, in the beautiful setting of the Reggia of Colorno, an open meeting day focused on the Schools of excellence and on the Métiers d'Art. From 11:00 a.m., after the welcome greetings of the authorities, the ALMA XI academic year's official opening, will take place with the participation of Gualtiero Marchesi, rector of ALMA, and contributions of managers and teachers of the school.
After that, the round table moderated by Claudio Della Seta, editor in chief of the TG5, "Métiers d'Art, School of excellence and employment in Italy" will take place; at the event will be present: Alberto Cavalli, Director of the Cologni Foundation; Stefano Micelli, Professor of the University Ca' Foscari of Venice; Gian Piero Brovedani, Director of the Scuola Mosaicisti del Friuli; Andrea Romano, Director of the TADS, Tarì Design School; Marco di Luccio, FAI-Fondo Ambiente Italiano. During the day, it will possible to visit the workshops curated by some of the italian Schools of excellence.
www.fondazionecologni.it
Pages Related to Food, Education
Filippo Villa
Milan, Masters, Jewellery
Starting 1980, Filippo Villa has been following the family path founded by the outstanding master goldsmith and excellence craftsman Benvenuto Villa in 1876. The tradition is now being continued through the exclusive models created by the very best team of craftsmen in town. In 1995, Filippo Villa decided to become the first goldsmith reintroducing the use of cufflinks, which had first enteredthe history of costume in the 18th century and had been forgotten along the last 20 years. Thanks to his skills, passion and undeniable savoir-faire, in 2018 Villa has been awarded the Fondazione Cologni's Prize MAM-Maestro d'Arte e Mestiere.
"Né arte, né design". Conference on applied arts in Italy
Milan, Conference, Communication
25 years from the historical conference which took place in February 1995 in Milan's Triennale, Fondazione Cologni is now promoting a new important meeting curated by Ugo La Pietra and Alberto Cavalli: a full day dedicated to exploring the discipline area of the applied arts within Italy's art crafts, internationally referred to as "decorative arts" or "craft",
Doppia Firma is flying to Grand Palais, Paris
Paris, Exhibition, Ceramic, Wood, Glass, porcelain
After the outstanding success of Doppia Firma in Milan, with 18,000 visitors who came to Villa Mozart to see the exhibition, the project by Fondazione Cologni dei Mestieri d'Arte with Living Corriere della Sera, and presented by the Michelangelo Foundation for Creativity and Craftsmanship, will access a new prestigious venue in Paris, on the occasion of the fourth edition of Révélations, from 23 to 26 May.
Doppia Firma 2019
Milan, Exhibition, Ceramic, Glass, porcelain
For the 2019 Salone del Mobile, the Michelangelo Foundation for Creativity and Craftsmanship is proud to present the fourth annual Doppia Firma: A Dialogue Between Design and Artisanal Excellence, in collaboration with the Fondazione Cologni dei Mestieri d'Arte and Living – the Corriere della Sera magazine for interiors, design and lifestyle.
The mechanics of monsters. From Carlo Rambaldi to Makinarium, Palazzo delle Esposizioni, Rome, until 6th January 2020
An exhibition dedicated to a genius of special effects in cinema can be seen at the Palazzo delle Esposizioni in Rome: Carlo Rambaldi, known for the most famous fantastic creatures, such as E.T, King Kong and Alien, to mention only the films with which he won an Oscar for the best special effects.
Craftsmanship goes to school. Two schools have joined the experimental project in Val d'Aosta
The idea of starting a training course linked to craftsmanship came into being at the latest meeting, in Udine, of the signatories of the International Charter of Artistic Craftsmanship;
#rialziAMO gli artigiani. The fund-raising for ateliers affected by "acqua alta" gets off to a start
Milan, Venice, Communication, Craftsmanship
In November, Venice was harshly affected by bad weather and floods, which caused incalculable damage to the lagoon city and, above all, to the artisans who have always worked with passion and dedication in their workshops.
Fondazione Cologni within Segnali d'Italia (Signs of Italian Excellence)
Milan, Communication
The "Segnali d'Italia" (Signs of Italian Excellence) campaign is coming to Milan to narrate 11 town tales highlighting the people, crafts, and neighbourhoods that are playing a role in making Milan a city open to integration, inclusiveness and excellence.
"Fracture", Charity Auction for the Doccia Museum
Florence, Auction, Communication, Jewelry
On 25 November 2019, at the Milanese gallery Officine Saffi, the jewels created by the students of LAO-Le Arti Orafe Jewellery School, who used the porcelain fragments from the Richard Ginori Factory, were auctioned by Sotheby's.
Noi Scarpelli. Una storia a Firenze
Firenze, Publishing, Communication, Mosaic, Homofaber
Nel cuore di Firenze, a pochi passi dal Museo del Bargello, è emozionante scoprire una delle più splendide realtà del nostro alto artigianato, ben nota ai cultori e conoscitori dei mestieri d'arte di eccellenza: è l'atelier Scarpelli
Manifatture Aperte, Milan, November 29-30
Milan, Exhibition
"Manifatture Aperte" is a success initiative of the city of Milan, that aims at presenting and sustaining urban manufactures and crafts activities thanks to a series of initiatives.
"YouNique", Villa Ciani and former Asilo Ciani, Lugano, 16-17 November
Lugano, Exhibition, Glass, Paper, Mosaic
The second edition of "YouNique. Artigianalità d'Eccellenza", (YouNique. Excellence Craftsmanship) the artistic craftsmanship exhibition market hosted by the evocative halls of Villa Ciani, the 18th century mansion facing Lago Ceresio in Lugano, is about to start.
The Contemporary Mosaic Biennale, Ravenna, until 24 November 2019
Ravenna, Exhibition, Mosaic
Until 24 November, on the occasion of the 6th edition of the "Contemporary Mosaic Biennial", the city of Ravenna will be alive with events, exhibitions and meetings. Many institutional sites will host site-specific installations and exhibitions, thus turning into exceptional galleries where ancient and contemporary art will engage in an ongoing dialogue.
Francesco Bissolotti from Cremona
Cremona, Exhibition, Music
Cremona's Museo del Violino pays tribute to one of the greatest contemporary violin makers: Francesco Bissolotti.
Toni Zuccheri, "About cocks and hens, hoopoes, owls, and other animals"
Milano, Exhibition, Wood, Glass
Until 13 October, Milan's Museo Bagatti Valsecchi is showcasing Toni Zuccheri's solo exhibition featuring a wide number of unique animal-themed works.
Fatti ad arte
Biella, Exhibition, Mosaic, shoes
"Fatti ad arte" (Made to Art), an event dedicated to high craftsmanship as an expression of the legacy of beauty and authenticity which includes, from the Renaissance onward, art, culture, and tradition, has now reached its third edition.
The 22nd ceramics celebration in Nove (VI), "Portoni aperti", 6-7-8 September
Nove, Exhibition, Ceramic
On 6-7-8 September, on the occasion of the 22nd edition of "Open Doors", the town of Nove, in the province of Vicenza, is alive with events, exhibitions, performances and meetings: three days to discover the secrets of the land and the magic of an ancient art like ceramics.
"Arte Contemporanea vs Artigianato", MAIN - Maison de l'Artisanat International
Aosta, Exhibition, Communication
Until 29 September, the halls of Gignod's MAIN (House of International Craftsmanship) will be open to visitors of "Contemporary Art versus Craftsmanship", an exhibition within the exhibition, prompted by the will to reflect on the relationship between art and craft, through the works of five contemporary artists reinterpreting the walking stick with their creations.
"Salone Internazionale del Restauro, dei Musei e della Imprese Culturali" Ferrara
Ferrara, Conference, Restauration
The International art Restoration Exhibition, acknowledged as a national event in the context of Cultural Heritage, has now reached its 26th edition.
Biennale of Art Schools
Russian, Exhibition, Communication
Between 2019 and 2020, the Biennale of Art Schools will support a moment of creativity and confrontation among secondary schools. The theme of this two-year period develops around the celebration of one of the most important Italian masters: Leonardo Da Vinci.
Morfologia delle meraviglie
Ostuni, Exhibition, Ceramic
This summer, Officine Saffi, Milan's renowned gallery devoted to contemporary authorial ceramics, reaches the Apulia region, in the territory of Ostuni, among the trulli and the pristine landscapes of Salento.
Clara Garesio, "Mirabilia e Naturalia. Ceramiche e carte"
Rome, Exhibition, Ceramic
Until 29 September, the Villa Torlonia Museums, at the Casina delle Civette in Rome, are showcasing the personal exhibition of ceramic artist Clara Garesio.
"Presepe Liberato", Istituto Caselli-De Sanctis, Parco di Capodimonte, Naples, from 4 to 31 July
Naples, Exhibition, Ceramic, Nativity
From 4 to 31 July, the Caselli-De Sanctis institute for ceramics and porcelain is showcasing the exhibition "Presepe Liberato" (A Free Nativity Scene).
"Dalle cave all'architettura", Ugo La Pietra's latest public work at Apricena (FG)
Foggia, Exhibition, Marble, stone
Ugo La Pietra left his mark again. This time at Apricena, in Apulia Region, where he created the public work "Dalle cave all'architettura" (From quarries to architecture) in the "Madre Pietra" Parco Museo Sculture.
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dei Mestieri d'Arte
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Mother Goddesses are a central feature of Roman religion, from Juno in Rome itself to Magna Mater to the numerous mother deities venerated in Northern Provinces, these cults appear to have appealed to those wanting to have children. Or were they? This day-school is going to explore the various aspects of Matres and Matronae, that went beyond the fertility cult and provided protection in life and after death, as well as a focus for tribal identity.
Dayschool: Friday, 6th October 2017 Time: 11am– 4pm.
Please note: The car park is a pay and display car park (£2).
*£28, if booked before 15th August, 2017.


Our retro-mirror photo booth is interactive, unlike those of traditional ones. The Retro Selfie Mirror that we have features a touch screen, posts photos directly to social media, and prints physical copies right away. Customers can also select backgrounds, draw pictures, and more using our interface.
Prices start at $150 per hour.


A trendy retro print in red, black, grey and ivory which will add a bold statement to your floor. This piece includes a folded finish, so the edges will not curl and is structured using non-shredding fibres -however it may require non-slip spray or an anti-slip fleece for hard flooring to ensure incidents are prevented. We also provide these products.


text:
coreo_aws_rule "elb-inventory" do
  action :define
  service :ElasticLoadBalancing
  link "http://kb.cloudcoreo.com/mydoc_all-inventory.html"
  include_violations_in_count false
  display_name "ELB Object Inventory"
  description "This rule performs an inventory on all Classic ELB's in the target AWS account."
  category "Inventory"
  suggested_action "None."
  level "Informational"
  objectives ["load_balancers"]
  audit_objects ["object.load_balancer_descriptions.load_balancer_name"]
  operators ["=~"]
  raise_when [//]
  id_map "object.load_balancer_descriptions.load_balancer_name"
end

coreo_aws_rule "elb-current-ssl-policy" do
  action :define
  service :ElasticLoadBalancing
  link "http://kb.cloudcoreo.com/mydoc_elb-current-ssl-policy.html"
  include_violations_in_count false
  display_name "ELB is using current SSL policy"
  description "Elastic Load Balancing (ELB) SSL policy is the latest Amazon predefined SSL policy"
  category "Informational"
  suggested_action "None."
  level "Informational"
  id_map "modifiers.load_balancer_name"
  objectives     ["load_balancers", "load_balancer_policies" ]
  audit_objects  ["", "object.policy_descriptions"]
  call_modifiers [{}, {:load_balancer_name => "load_balancer_descriptions.load_balancer_name"}]
  formulas       ["", "jmespath.[].policy_attribute_descriptions[?attribute_name == 'Reference-Security-Policy'].attribute_value"]
  operators      ["", "=~"]
  raise_when     ["", /\[\"?(?:ELBSecurityPolicy-2016-08)?\"?\]/]
  id_map "modifiers.load_balancer_name"
end

coreo_aws_rule_runner "advise-elb" do
  rules ${AUDIT_AWS_ELB_ALERT_LIST}
  service :ElasticLoadBalancing
  action :run
  regions ${AUDIT_AWS_ELB_REGIONS}
  filter(${FILTERED_OBJECTS}) if ${FILTERED_OBJECTS}
end


Dr. Perales accepts the following list of insurance providers. Select your insurance provider to see more details.
I am a board-certified medical oncologist with expertise in donor-derived hematopoietic (blood-forming) stem cell transplantation. Hematopoietic stem cells from a donor other than the patient can cure many patients who have diseases of the blood and bone marrow, including leukemias and lymphomas. The donor stem cells can come from different sources (related or unrelated donors, and bone marrow, peripheral blood, or umbilical cord blood units) and can be modified in different ways before transplantation to enhance their effectiveness.
Along with colleagues here, I am participating in a number of studies designed to improve outcomes in patients undergoing stem cell transplantation, including finding ways to lower the risk of complications, relapse, and graft-versus-host disease. In particular, I am leading a clinical trial in patients who have advanced Hodgkin lymphoma; the goal of the trial is to determine the safest way to perform a transplant using stem cells from a donor in patients with relapsed Hodgkin lymphoma.
I also conduct translational clinical research investigating new ways to enhance the recovery of the immune system after a transplant and ways to help the immune system fight hematologic malignancies. My colleagues and I are investigating new agents such as interleukin-7 and KGF to enhance immune recovery, as well as new approaches to generate specialized T cells that will specifically target hematologic malignancies.
My practice consists of patients with a variety of hematologic malignancies who are in need of an allogeneic transplant, including patients with acute myelogenous leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, chronic lymphocytic leukemia, non-Hodgkin lymphoma, and Hodgkin lymphoma. The goal of my practice and clinical research is to be able to offer every patient in need of a transplant the opportunity to undergo this potentially curative therapy.
As Director of Memorial Sloan Kettering's Adult Bone Marrow Transplantation Fellowship Program, I am responsible for coordinating the training and education of tomorrow's generation of stem cell transplanters.
Visit PubMed for a full listing of Dr. Perales's journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.


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text:
Muhammad Nur Aiman Mohd Zariff (born 1 October 1997) is a Malaysian professional racing cyclist, who currently rides for UCI Continental team .

Major results

2013
 2nd Time trial, National Junior Road Championships
2017
 1st  Team pursuit, Southeast Asian Games
 5th Overall Tour de Selangor
2018
 6th Overall Tour of Indonesia
2019
 6th Overall Tour of Peninsular
 6th Overall Tour de Selangor
1st  Young rider classification
2020
 1st  Mountains classification, Tour de Langkawi
 2nd Overall Cambodia Bay Cycling Tour
1st  Points classification
2021
 2nd Time trial National Road Championships
2022
 1st  Mountains classification, Tour de Langkawi

References

External links

Living people
1997 births
Malaysian male cyclists
Southeast Asian Games medalists in cycling
Southeast Asian Games gold medalists for Malaysia
Competitors at the 2017 Southeast Asian Games
Cyclists at the 2018 Asian Games
Competitors at the 2021 Southeast Asian Games

redpajama_set_name: RedPajamaWikipedia


text:
Collection / Artwork / Posters / Little Hitter
Little Hitter
Hand-Signed ?
32" by 24"
(81.28 cm by 60.96 cm)
Choose an optionUnsigned Clear
Questions about buying art? Visit the FAQ section.
Artwork shown in scale for illustrative purposes only.
One of LeRoy's first forays into art was creating posters for local merchants at a young age to advertise their store sales. Later, as an established artist, he often made posters to commemorate and promote special sporting and cultural events. Neiman's posters remain a tribute to his vibrant work and life.
Neiman painted every type of sporting event during his lifetime, with his influence earning him the title of "Father of Contemporary Sport Art." As the official artist of five Olympics, his art reached millions of people via al fresco paintings of the competitions. His comprehensive coverage of other sporting events includes the Super Bowl, the World Series, the Kentucky Derby, championship boxing, PGA and The Masters golf tournament, and the Tour de France.
Brooklyn Bridge – Small
Chicago Tribune Bike Rally
The Race – The Boston Marathon


We regularly host live music, quiz nights and other great events in the cafe, but you can also book the space for your own event or meeting. The first hour costs £30, with every hour thereafter an additional £15 - we can also supply delicious food and drinks.
Drop Susan a line on susan@velocitylove.co.uk or call 01463 419 956 for more info.


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Are you thinking about adding Lunyr (LUN) to your cryptocurrency portfolio. Lunyr price and other LUN cryptocurrency market information, Lunyr (LUN) currency convertions, live Lunyr ticker price, Lunyr is a token on the Ethereum platform.
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My name is Lee Wood, and on behalf of my family, I would love to start off by thanking each doctor and their team that has helped my family get back to our best. I am a mother of three kids who were always involved in some kind of sport growing up. Their primary sports were soccer and ultimate frisbee during high school and college. I also coach the high school competitive, ultimate frisbee team and the women's club team.
I first got involved with Andrews Sports Medicine back in 2014 when my daughter, Mary, came in for an ankle sprain that was later aggravated into torn ligaments. We had an amazing experience with Dr. Norman Waldrop. She had been injured during a game within the club season and she had hopes of playing on her high school team in the spring. We loved Dr. Waldrop a lot because he took his time to actually listen to her and understand what she wanted and what she planned to do.
We saw other doctors before coming to Andrews and many of them suggested surgery, but Dr. Waldrop didn't. He thought we could just work on strengthening her ankle. He talked her through other options besides surgery, which the other doctors didn't really do. When it came around the time for her to start playing again, my daughter had some reservations and anxiety, which Dr. Waldrop quickly put to rest. He ordered another MRI to make sure everyone was at ease with my daughter getting back onto the soccer field.
The next year, my son, Willis, came to Andrews during his freshman year at Appalachian State University for an injury to his right ankle. After seeing an orthopedist in North Carolina, we took him to see his primary care physician and later Andrews to see Dr. Jose Ortega for further evaluation and treatment. Luckily, his injury wasn't terrible and after a few rounds of physical therapy and an running program, my son's ankle felt better.
Finally, a couple of weeks ago, I returned to Andrews with my mother after an accident that left her in the ER. Dr. Michael Ryan saw us and was very timely, thorough and respectful. He took his time to make sure he did his job correctly. My mother is healing up nicely and we are both happy with the experience Dr. Ryan gave us.
Overall, I have loved the experience I have had with Andrews Sports Medicine over the years. Whenever one of my ultimate players within the club teams has an injury, I make sure to always refer them to Andrews Sports Medicine because I know they will be taken care of quickly and correctly. I have nothing but good things to say about Andrews!


Meanwhile lets just say that we are proud Kate Eberlein contributed a whooping 17 entries.
"Grand Crew" – 2 bottles at $40 or less "Premier Crew" – 1 bottle $60 – $100 "Clean-Up Crew" – receive 6 bottles for $90 Prices are before tax.
Wine Folly – Nebbiolo in a Nutshell!
© 2016 Village Wines of Glendale. All Rights Reserved.


Hoodwinked (2005) on Netflix | Trailer Nite - Find something to watch tonight.
Everyone knows the story of Little Red Riding Hood...or so they think. That's all about to change because no one has ever seen their favorite fairy tale quite like this -- turned upside-down, inside-out and reinvented as a computer-animated caper comedy that at last reveals the shocking true-crime investigation behind the legend.


Corruption in the customs system is highlighted as a particular problem. File photo.
Corruption remains a major headache when it comes to doing trade with the Philippines, a report by the Office of the US Trade Representative says.
In its 2018 National Trade Estimate Report of Foreign Trade Barriers, the USTR said corruption remains a "pervasive" issue in the Philippines. It added that the US would continue to urge the country to improve matters.
"National and local government agencies, particularly Bureau of Customs, are beset with various corruption issues," the USTR's report said.
As it also did last year, the USTR highlighted concerns expressed by investors about "the propensity of Philippine courts and regulators to stray beyond matters of legal interpretation into policymaking, as well as the lack of transparency in judicial and regulatory processes".
"Investors have also raised concerns about courts being influenced by bribery and improperly issuing temporary restraining orders to impede legitimate commerce," the report said.
The report divides foreign trade barriers into 10 categories, which cover government-imposed measures and policies that restrict, prevent, or impede the international exchange of goods and services.
To give one example, the US continues to press the Philippine government to remove requirements that treat frozen meat differently from fresh.
For intellectual property rights protection, the report said US rights holders have expressed concerns about the availability of pirated and counterfeit goods in the Philippines, and the lack of action to stem the trade.
The USTR also cited restrictions on foreign investment in the country as a barrier to investment.
However, the USTR recognised the government's efforts to "take immediate steps to lift or ease existing restrictions on foreign participation" in a number of investment areas.
The USTR has also deepened its focus on barriers to digital trade. It cited limitations affecting cloud computing and ride-hailing taxi apps.
Paolo Duterte rarely has a problem smuggling stuff into the country.
Maybe because he has good connections.