my 10in f3.27 uncoated mirror test.
In final stages of mounting my 6x point flotation cell to my OTA.Been testing uncoated mirror in hot bright daylight, looking at Yachts and people in the bay.The mirror is , to me amazing ! Of course I,m biased ,having achieved an 10in f3.27 19mm thick mirror that works very well, having only done an 8in f8 60yrs ago. And as an Octogenerian too - so much for the " old and greys", we still have a life, and can use it !
Focus is sharp, and abrupt - despite not being properly collimated , as the mirror cell is only friction fitted to cell , until all eyepieces focus.My 24mm focuses sharply, as does my 14mm, but cannot get focus ( in daylight ) on my 6.7 and 4.7 eyepieces .Weather is clearing so I,ll try tonight .Not sure whether I have too much or too little" IN FOCUS " for the shorter f eyepieces. This mirror has real potential inspite of it,s short focal length , in fact I,d be pleased with it as a terrestial scope to look at cruise ships entering our port, and yacht races etc. So Danny and others, you have all done a great job of advising me inspite of my terrible Ronchi photos ! Thank you macleod.
It's gonna be a great one once you get the aluminum on it. Keep us posted !
Nice! Those are big exit pupils, though: 7.3mm at 35x and 4.3mm at 59x. So, bright daytime... would be using a lot less than the entire 10-inch of aperture. Night use, at higher mag, will be a more severe test.
Frustrated by "new telescope curse" - beautiful warm days, but evenings clouded over, sometimes clearing early morning.However managed a few minutes tonight between banks of fast flowing alto- cirrus cloud.Generally stars look suitably sharp, and coma looks no worse than my f4.7 scope with a "top" mirror.I had to test before the mirror was acclimatised - to even get a view between the cloud. So called breakout looks same both sides of focus , although this was a rushed test and I,m NOT saying its a fair test.Did notice at higher power that OUTSIDE of focus the central shadow was very black, with one bright ring around it.However as I,ve said, all I can assume from this brief foray is - the scope focuses sharply, coma is not bad for f3.27 in my book, and the whole thing has promise.More tests when sky clears later in April !!
One "rave " I do have - the "offset "spider vanes are superb at holding the secondary firmly, and the Ross Sackett / Strock mirror holder design ( as shown on Pinbouts 3D design page) , is both very lightweight and easy to adjust, and holds collimation.Success story there ! I,m making an offset spider to hold my Astrosystems mirror holder on my other scope, I,m so rapped by them.More later, Macleod.
You might try Ronchi at the eyepiece to get one more test input. Straight lines. Should agree with other tests. Check out the Solar system objects with the uncoated.
Edited by ccaissie, 01 April 2019 - 06:29 AM.
Well clear skies at last ! All my comments are subjective, in that I,m in no position to interpret star tests. So my 10in f3.3 mirror is , in my opinion a keeper, thank goodness.The mirror is UNCOATED.
Moon very sharp, mountain tips on terminator sharply silhouetted against dark sky background.Uncoated mirror reduced glare, so detail on lunar surface was spectacular.Orion Nebula extensive,much better than I thought it would be uncoated, and I could see all 4x trapezium stars at 100x . Similarly Eta Carina nebula was visible , and enjoyable.Scanning the Milky Way was fun and amazingly for f3.3 coma was not at all bad ! Not what I had been led to believe by any means. My simple cheap GSO Coma corrector ( modified as per above in pinned posts) cleaned it up nicely ! So much for " cheap Chinese optics" ! Attempts at star testing were "dismal". Mirror looked better outside of focus than inside, although the shadow of the secondary looked similar both sides. About all I can say - this is NOT the best mirror on the block, but it works to me very well visually up to 250x , however the view is pretty dim at this magnifcation uncoated, so really cannot fully judge.This mirror is 19mm float annealed glass, mounted on a 6x point cell in a 12in epoxied Sonotube.No signs of astigmatism fortunately.So what is my reaction to fast mirrors, after 6yrs using a 10in f4.7 Zambuto Dob, home built ? You obviously can,t compare the optics, Carl,s mirror is supurb on Planets and stars etc.But the f3.3 is still very good for wide field Milky Way cruising, and DSO hunting , and does NOT disappoint me in any way - in fact I get great satisfaction as an 83yr old , to think I made a fast thin mirror that works as well as this does, and it took only four months to grind/figure start to finish.The real test will be the Planets later in the year - I,m not getting up early morning in a NZ winter to view them ! However this scope was built for Deep Sky cruising and not Solar System stuff - the Zambuto is for that.
is that with the cc in the focuser or not.
what eyepiece, if it has a built in barlow, it will add correction to the reading.
too close to the caustic gives false readings, too far out is too insensitive.
Edited by Pinbout, 11 April 2019 - 06:13 AM.
Happy to see you enjoying it! That's what matters. Congrats!
Hi Danny, I tried star test just de- centering both ways until I got initial break out.Probably .5mm both ways. Used a 6.7mm ES eyepiece @ 123x. Could not get anything approaching your pics ! I,m not sure about my old eyes - I,ve just had Cataract surgery 4 weeks ago, corrected to infinity, and it has "changed my life ", literally. I can see amazingly into distance, and colours great. But in past out of fun / curiosity I,ve tried to star test my Zambuto mirror , but still got rubbish views ! I do recall clearly in 1965 when I was 30yr old and my eyes young , I star tested my own 8in f8 mirror, and clearly remember seeing several concentric rings as you show - but never managed it since. By way NO c.c when I tested.All I could get was the central black dot, and one bright ring . Thank you for taking an interest Danny, and all the advice you gave me, I really appreciated it. In the long run this optic does what I want deep sky, so I,ll get it coated.


Discussion in '3DS - Flashcards & Custom Firmwares' started by wolfidroid, Aug 25, 2018.
I have a N2DS XL with luma3ds 9.1 and fastboot3ds and i am thinking of buying a gateway3ds. How do I use the gateway with Luma? I am on firmware version 11.7.0-40E.
Please don't waste your money on any 3DS flashcart. Gateway 3DS hasn't updated in 2 years and the team has since abandoned the cart for Stargate3DS (which they also abandoned right after the release.) It's honestly cheaper to buy a larger microSD card than it is to buy a Gateway 3DS, which is what I recommend doing.
so a flashcard isn't worth it. is there another way to get free games now that the 3ds title keys website doesn't work without searching for cias online?
Realistically what you said is counterintuitive. You still have to go through the same process of finding .3DS roms as you would to get .CIA ROMs. You are going to to have to get them from the same source regardless.
A flashcart isn't worth it because all of them haven't updated to worth the price tag added on them. Whereas you can get a microSD for the same price (often cheaper) and accomplish the same results, but with better support.
Migrating Gateway3DS games/saves to Luma3DS CFW?


Mattress GhostBed website coupon codes August With their ingenious cooling system and distinct suppleness level – the Ghost Bed Sleep Mattresses are quickly getting support in the market. Ghost Bed Sleep Mattresses are the only ones which are used with 1-year risk-free sleep trial as we have not seen anything like this prior to.
The Ghost Bed could be taken into consideration as a well-rounded mattress with ultra-dense foam framework and also equilibrium levels of assistances. It is developed as well as produced with matchless breathing air flow, classic memory foam, woven material as well as lots of various other unique functions. Hence, the Ghost Bed is a contemporary mattress most certainly – to offer sleepers with a cool as well as comfortable evening of sleep. The combined efficiency of its leading layer including gel memory foam, its special system as well as its incredible quilted cover the Ghost Bed definitely have the side over the rest. Each of these attributes maintains your mattress like brand-new for several years as well as years. Without a doubt, these attributes will certainly bring an amazing evening rest experience for both of you. When it concerns gifting as well as satisfying, our team believe there is nothing much better compared to Ghost Bed Sleep Mattresses nowadays. Walk around, and also you will certainly discover agitated individuals with weak minds. For the most parts, problems connected to rest deprivation can be addressed with the aid of basic modifications in sleeping practices and equipments.
Mattress GhostBed website coupon codes August How Firm are the Ghost Bed Sleep Mattresses?
Unlike several other memory foam cushions, the ones from the Ghost Bed are created and constructed with one firmness degree just – moderate company. At the suppleness range, you will certainly discover any type of cushion from Ghost Bed at a level 5 from 10 around. Inning accordance with our research, this degree of firmness fulfills the demands of the majority of normal sleepers. A revelation has actually been made in a current study that the majority of individuals choose a mattress that lives in between a suppleness degree 5 as well as 7 on a range of 10. Without a doubt, it's the Ghost Bed just that fits this mold. Being a high-density foam mattress that provides higher durability – the Ghost Bed has a very acknowledged hug and shape that allows your body to sink right into the foams. When it concerns the assistance capabilities, the general assistance offered by Ghost Bed is great. Whether you are a belly, side or back sleeper because of its 3″ layer of comfortable memory foam and 1″ gel foam quilted cover integrated, you will certainly discover sufficient support.
3. Below comes the third layer; it is the point where the actual distinction lies. This layer is developed from Nectar's very own developed and also patented LushFoam. This foam is taken into consideration (and also truly so) as the costs gel memory foam on the market.
Yes! The Ghost Bed Sleep Mattresses are offered with "Forever Warranty," "Free Shipping" as well as at extremely economical costs. We think, the Ghost Bed is the most phenomenal acquisition choice offered with balanced features. The quality of your bed mattress is something directly associated to the overall high quality of your rest. In situation if you are facing sleep loss and you are satisfied with your resting habits than you must take into consideration Ghost Bed as they are providing a yearlong totally free trial also.


Donna Whitehead: What is it about Bob?
It was crunch time, one day before the Destination Imagination tournament and my son and his friend were the only two left of a five-person team able to go to Saturday's competition. That's when Bob stepped in as a last minute replacement.
It was crunch time. One day before the Destination Imagination tournament, and my son and his friend were the only two left of a five-person team able to go to Saturday's competition. That's when Bob stepped in as a last-minute replacement.
The three of them went on performing their hastily rewritten skit with Bob in the role of cameraman. They didn't win the competition, but they won rave reviews and a special award, inspired lots of laughter and brought some people to their feet with applause. They were a hit -- my son, his friend and Bob.
That was only the beginning of Bob's amazing appeal. Since his unexpected debut at the tournament, Bob has won friends and admirers wherever he goes. He has starred as Elvis in a musical murder mystery, was featured in my son's class yearbook, attended my son's teacher's retirement party and got a volunteer job at the Plainville Public Library.
It may not seem like much to you but we've all been tremendously impressed by Bob's accomplishments considering he's only about 4 feet tall, is made of cardboard and owes his friendly grin to a black magic marker.
When Plainville Public Librarian Melissa Campbell visited the sixth-graders for a biography luncheon she heard Bob's story and was so impressed she asked Bob to come to the library when school got out and help with the summer reading program.
After school ended, Bob spent a few days at our house, hanging out on the coach. He quickly became a favorite of our cat who slept on Bob's lap (an honor few earn). Then my son dropped him off at his new post. Before the day was over one of his sixth-grade friends had paid a visit to the library and e-mails went out announcing Bob was at the library and on the job.
It's the perfect job for Bob who has already proved so inspirational to a classroom of sixth-graders, their teachers and the other students and adults he has met.
So far at the library, Bob's gotten to wear a cool space suit with a NASA label, taken part in story time and play Frisbee. He's right at home surrounded by books and young enthusiastic readers just like he was Plainville's Wood School.
So what is it about Bob? What's the secret of his success? The key to his popularity?
I believe Bob brings about a sense of fun and imagination in those around him. When with Bob it's easy to suspend disbelief and be a bit of a child again. And I don't think Bob would mind if I noted he also credits his success to the imagination and sense of humor of the Wood School sixth-grade class, which took him to heart.
Bob's a good friend. He stepped in when my son and his buddy needed a hand. Their belief in him inspired their friends to believe in him too. Those around Bob weren't afraid to be seen hanging out with a cardboard guy with a colorful print shirt and cool shades or even give him a lead in the school play.
Bob's very simple and accommodating. Bob's willing to be whatever you want to him to be. You just have to believe in him.
Belief and imagination — isn't that what summer reading is all about?
You can see Bob on the Plainville Public Library Web site at www.plainvillepubliclibrary.org or stop by in person, give him my regards and let him know what a great job he's doing. Or visit your own local public library and see what fun and exciting events are going on with their reading programs this summer.
Donna Whitehead is editor of the Easton Journal, Mansfield News and Norton Mirror. She can be reached at dwhitehe@cnc.com.


text:
$LOAD_PATH[0, 0] = File.join(File.dirname(__FILE__), '..', 'lib')

require 'midilib/sequence'
require 'midilib/consts'

DEFAULT_MIDI_TEST_FILE = 'NoFences.mid'

seq = MIDI::Sequence.new()
File.open(ARGV[0] || DEFAULT_MIDI_TEST_FILE, 'rb') do |file|
  # The block we pass in to Sequence.read is called at the end of every
  # track read. It is optional, but is useful for progress reports.
  seq.read(file) do |track, num_tracks, i|
    puts "read track #{track ? track.name : ''} (#{i} of #{num_tracks})"
  end
end

include MIDI
seq.each do |track|
  track.each do |event|
    puts event.data if event.kind_of?(MIDI::MetaEvent) &&
    [META_TEXT, META_COPYRIGHT, META_SEQ_NAME, META_INSTRUMENT,
      META_LYRIC, META_CUE, META_MARKER].include?(event.meta_type)
  end
end

redpajama_set_name: RedPajamaGithub


Toyota has topped the WRC podium for the first time in 18 years, after Jari-Matti Latvala took victory at Rally Sweden.
The Finnish driver came into the second round of the 2017 championship narrowly behind Sebastien Ogier in the driver's championship.
However, after scoring the fastest time on six of the 18 stages over the weekend, Latvala is now at the top of the championship scoreboard.
After winning the first, fourth and thirteenth rounds of the weekend's rally, Latvala came into the final day with just a 3.8-second advantage over the closest competitor.
However, he went on to take victory in SS16, SS17 and SS18 in his Yaris, and finished the overall rally ahead of Ott Tanak in second and Sebastien Ogier in third, both piloting new Fiesta WRCs.
After the race, Latvala said: "I am so, so happy. For a new team and new car to win its second rally: I really have no words. I think I drove my best power stage ever today. Huge thanks to all the team.
"Now we are super-motivated to continue like this: I just can't wait to get to Mexico. It's fantastic to win but I also feel very sorry for Thierry Neuville, who lost the lead yesterday at the super special stage," the 31-year-old added.
"I have been in a similar situation myself in the past, so I completely understand how he must be feeling now. We know we were lucky, so we need to carry on improving and working for our goal."


Odom, Adrian August 29, 1935.
This newspaper is part of the collection entitled: The Brand (Hereford, TX) and two others and was provided by Deaf Smith County Library to The Portal to Texas History, a digital repository hosted by the UNT Libraries. More information about this issue can be viewed below.
Feb. 23, 2017, 11:32 a.m.
Odom, Adrian. The Hereford Brand (Hereford, Tex.), Vol. 35TH YEAR, No. 34, Ed. 1 Thursday, August 29, 1935, newspaper, August 29, 1935; Hereford, Texas. (https://texashistory.unt.edu/ark:/67531/metapth583917/: accessed April 23, 2019), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting Deaf Smith County Library.


text:
Q: Proper way to wait all tasks while still updating the UI thread I'm trying to download the page source from multiple urls using tasks to download multiple sites at one time.  The issue is that I want to keep the UI updated as each individual task completes.  When I try to wait all tasks it stops updating the UI until they all finish.  Here is the current code that I am using.
EDIT: I'm assuming I was down voted due to me not explaining well enough.  I guess a better way to put this is why is the continueWith not being run before Task.WaitAll.  I want the UI to update on each completion of the source being downloaded. Once that is all finished then the listbox would be updated to let the user know everything is done.
   private void btnGetPages_Click(object sender, EventArgs e)
    {

        for (int i = 1; i < 11; i++)
        {
            string url = $"http://someURL/page-{i}.html";
            listBoxStatus.Items.Add($"Downloading source from {url}...");

            Task t = new Task(() =>
            {
                DownloadSource(url);
            });

            t.ContinueWith(prevTask => listBoxStatus.Items.Add($"Finished Downloading {url} source..."), TaskScheduler.FromCurrentSynchronizationContext());
            tasks.Add(t);
            t.Start();
        }

        Task.WaitAll(tasks.ToArray());
        listBoxStatus.Items.Add("All Source files have completed...");

    }

    private void DownloadSource(string url)
    {
        var web = new HtmlWeb();
        var doc = web.Load(url);
        pageSource += doc.Text;
    }

A: You really should use an asynchronous download method based on HttpClient instead of the synchronous method you are showing. Lacking that, I'll use this one:
private async Task DownloadSourceAsync(string url)
{
    await Task.Run(() => DownloadSource(url));

    listBoxStatus.Items.Add($"Finished Downloading {url} source...");
}

Then, you can make your btnGetPages_Click method something like this:
private async void btnGetPages_Click(object sender, EventArgs e)
{
    var tasks = new List<Task>();

    for (int i = 1; i < 11; i++)
    {
        string url = $"http://someURL/page-{i}.html";
        listBoxStatus.Items.Add($"Downloading source from {url}...");

        tasks.Add(DownloadSourceAsync(url));
    }

    Task.WaitAll(tasks.ToArray());
    listBoxStatus.Items.Add("All Source files have completed...");
}

redpajama_set_name: RedPajamaStackExchange


text:
Supermarine Channel var en engelsk passagerarflygbåt som tillverkades av ombyggda Air Department Flying Boat av Supermarine Aviation efter första världskriget.

När första världskriget var över sålde Royal Naval Air Service 19 AD Flying Boat till Supermarine Aviation. Vid Supermarine byggdes flygkroppen om och försågs med ytterligare en sittbrunn, detta medgav att flygbåten förutom pilot kunde medföra tre passagerare. Flygbåtens originalmotor Hispano-Suiza byttes ut met en 160 hk Beardmore-motor dessa civila flygbåtar fick beteckningen Channel I. Under 1920 provade man att ersätta originalmotorn med en 240 hk Armstrong Siddeley Puma-motor, efter flera andra modifieringar betecknades den nya flygbåten Channel II.

Den Svenska marinen sände 1921 två högre officerare till England och Vickers fabriker vid Weybridge för att studera Vickers Viking, som var en flygbåt av amfibietyp med uppfällbara hjul för start och landning både på land och på vatten). Men under besöket fick man även se Channel II, som under vintertid kunde förses med ett skidställ för landning på snö och is. Eftersom flygbåten var dubbeldäckad blev den även intressant som ett jämförelseobjekt mot det tyska monoflygplanet Caspar S.I. Chefen för Marinens Flygväsende hade redan i slutet av december 1920 i en hemställan begärt att få köpa sex Channel II flygbåtar, men detta avslogs av marinförvaltningen. Efter besöket i England 1921 tillstyrktes köpet av en flygbåt för utprovning. Flygbåten anlände till Galärvarvet och TDS där det iordningställdes där för första flygproven mot Hansan. Eftersom det var en del barnsjukdomar på Hansaflygplanet kom inga jämförande prov igång. Under en flygning vid Hårsfjärden 22 september 1922 totalhavererade flygbåten. Besättningen klarade sig oskadad, men endast motorn kunde bärgas, och kom senare att monteras in på prov i en Heinkel HE 1.

Varianter
Channel I - ombyggda AD Flying Boat med en 160 hk Beardmore-motor.
Channel II - ombyggda AD Flying Boat med en 240 hk Armstrong Siddeley Puma-motor.

Amfibieflygplan
Brittiska spaningsflygplan
Passagerarflygplan
Channel

redpajama_set_name: RedPajamaWikipedia


Independent marketing agency Orchard has been named Australia's first certified content partner Veeva's closed-loop marketing (CLM) platform.
CLM allows marketers to collect and analyse customer data and use this valuable information to improve strategic direction and enhance future content. By 'closing the loop', it creates a continuous cycle of information gathering and strategy refinement.
In Veeva, it means that the marketing team can track which content and messaging has resonated most with their customers, so they understand what has worked and what has not and most importantly what to change.
CLM also helps clients learn more about their target market, tailor sales calls to improve customer experience and satisfaction and evaluate the value of marketing activities, reducing overall costs.
Since 2006, Orchard has created more than 200 e-detailers for some of the world's leading pharmaceutical companies, including Pfizer, GSK and MSD – many of them using the Veeva platform.
As a certified Veeva content partner in CLM, Orchard specialises in creating engaging and impactful content that utilises all the capabilities of Veeva.
Wai Kwok, managing partner at Orchard, said: "Orchard is delighted to be the first approved Veeva CLM content partner in Australia. The market for detail aid platforms is maturing, and it's clear that Veeva is an established leader in this space.
"We're observing that client needs are rapidly evolving. Beyond ensuring their representatives are well-equipped to communicate their clinical messages, there's a desire to fully integrate the end-to-end functionality and power of the Veeva platform.


Realty Masters of FL offers quality Pensacola Real Estate Services including Property Management, Sales, Rentals, and Community Association Management in Escambia and Santa Rosa Counties in Northwest Florida.
Realty Masters is the #1 Property Management leasing company in the local area! We rent a house Every Day in Pensacola! Now accepting new properties in good condition.
Contact our office today at (850) 473-3983 with your Pensacola Real Estate questions. We have over 45 rental properties including homes and apartments in the Pensacola area.


text:
Woman goes to doctor with 'food poisoning' and learns she has colon cancer
Updated: 8:02 AM EDT Apr 2, 2018
Diana Zepeda, of Washington, D.C., says she initially thought her stomach pains were due to an unhealthy diet. But even after cutting out grains, dairy and sugar for an entire month, the symptoms grew worse. Three months later, a doctor tried treating her for food poisoning, but the antibiotics didn't help. Soon after, a partial colonoscopy revealed a much scarier diagnosis for the 34-year-old. Watch the video above to hear the whole story.
Diana Zepeda, of Washington, D.C., says she initially thought her stomach pains were due to an unhealthy diet. But even after cutting out grains, dairy and sugar for an entire month, the symptoms grew worse.
32-year-old nurse shocked when belly pain turns out to be colon cancer
Three months later, a doctor tried treating her for food poisoning, but the antibiotics didn't help.
Soon after, a partial colonoscopy revealed a much scarier diagnosis for the 34-year-old.
Watch the video above to hear the whole story.

redpajama_set_name: RedPajamaCommonCrawl


From February until June 2017, the 16 participants of the VSPS Migration Program will conduct meetings in secondary schools in their home countries: Czechia, Germany, Hungary, Poland and Slovakia. The series of courses, titled "Critical Thinking on Migration Workshops", is a result of the preparatory sessions in Warsaw, Strasbourg and Cracow. The participants attended various lectures on public presentations, methods of working with youth, countering hate speech and expert-level discussions on migration, which were used to design the scenarios and content for meetings with high school students.
The aim of the Critical Thinking on Migration Workshops is to develop the analytical skills of students over the age of 16, by encouraging to scrutinize news and arguments presented to them. By using the example of the refugee and migration crises, the participants will learn how to distinguish facts from fake news, acquire knowledge of fundamental definitions crucial to understanding the current issues and have a chance to express their own views.
To learn more or join the workshops, please click HERE or contact Ms. Paulina Budek at pbudek@diplomats.pl.


text:
RetroSection
Bringing Past To Present
Commodorathon
30 Days of Gaming
Contact RetroBear
Posts tagged Retro Memories
RetroReview : February Free-For-All 2012 – 8th February 2012
Posted by RetroBear in Retro Reviews
Dateline : 8th February 2012
That old lycra fetish is coming out again. Time to strap on the spandex, do up the laces and posedown for WWF Wrestlemania on the Amiga……..
It's an impressive looking box, just a shame the contents suck
1980's, 1990's, Amiga 500, Bad Games, Game Rage, Retro Memories, Review, Sports Games
RetroReview : February-Free-For-All – February 7th 2012
Get your motors running, it's Super Hang On on the Sega Mega Drive…….
Big bikes, big graphics, big ride
1980's, Arcade Conversions, Megadrive, Retro Memories, Review, Sega, Sports Games
Commodorathon : Games 37-42
Feb 8th
Posted by RetroBear in Commodorathon
Dateline 7th February 2012
Game 42 marks the 10%-ish mark of the Commodorathon. To say it's been an arduous trek so far is to say that elephants are made of sheet metal. Still it doesn't help that the six games chosen at random tend to be just that – random. Cacky old arcade conversions, lame film-tie ins and the great, great grandson of Championship Manager lay in wait in this next batch……..
The first landmark of the Commodorathon
1980's, 1990's, Arcade Conversions, Bad Games, Commodore C64, Game Rage, Movie Games, Platform Games, Retro Memories, Review, Sega, Sports Games, Top Tens
One wonders what goes through games developer's minds before they hit that eureka moment, the one that all of a sudden seems like a dashed good idea. More often they are right – in the case of one of the games below – and sometimes they are wide of the mark – as in the case of our other game here. It's that whole lottery thing where you never quite know if this will be the winning ticket, the one that sets you up.
George Lucas gets one of these every time someone brings out new technology so he can carry on butchering all the Star Wars films
1980's, 1990's, 2000's, Arcade Conversions, Atari Lynx, Handheld Console, Retro Memories, Review, Sega, Sega Dreamcast
RetroReview : February Free-For-All – 5th February 2012
What better way to banish those late winter blues than with some top notch retro gaming classics. Well that is the plan, and whether it turns out like that is another thing entirely. Up next, a variation on a successful character and an entry in one of the more successful puzzle franchises ever. If you like hats and bubbles then this could be the column for you………
See it is possible.............
1980's, 2000's, Arcade Conversions, Atari, Atari Lynx, Game Rage, Handheld Console, Pac Man, Platform Games, Puzzle Games, Retro Memories, Review, Sega, Sega Dreamcast
Being one of the biggest weekends in the American sporting calendar, you may wonder what significance the playing of Super Bowl 46 would have on us here in the UK. Well you might be surprised to know that tens of thousands of us will be sitting up well into the early hours of Monday morning watching those padded up superstars of the NFL bash each other senseless. It does seem quite funny to call the winners World Champions though, seeing as the sport is only played by American teams…………I can hear that can of worms opening from here…….
Giants vs Patriots - who's going to win ? Who cares ?
1980's, 1990's, Amiga 500, Game Rage, Megadrive, Retro Memories, Review, Sega, Sports Games
RetroReview : February Free-For-All – 3rd February 2012
While the weather outside is certainly frightening, inside there is plenty of delighting going on. That's the joy of having a hobby like retro gaming – you don't have to go very far, it never gets rained off and it's always warm when you do it. I know that's not such a good advertisement for healthy living and all that kind of stuff, but when have I ever lived by the rules ?
OK it could have been a lot worse weather-wise..........
1980's, Atari VCS, Movie Games, Retro Memories, Review
RetroReview : The February Free-For-All – 2nd February 2012
Feb 3rd
Dateline 2nd February 2012
Couldn't have put it better myself............
There is very much a handheld theme to the start of the February Free-For-All, and there is absolutely nothing wrong with that. Portable gaming is available so freely now because of the advent of Smart Phones, but back in the 80's and 90's such a thing was a very rare beast indeed. So much so that a lot of great games have either been forgotten about or are not appreciated by today's audience. One would hope the more visible these games are made, the more people will take an interest in them.
1990's, Handheld Console, Movie Games, Nintendo, Retro Memories, Review
RetroReview : The February Free-For-All – 1st February 2012
Feb 2nd
Posted by RetroBear in Everything Else
Dateline 1st February 2012
Not quite a box of chocolates, but you still don't know what you are going to get
February is a funny old month – long enough away from Christmas for it to be a fond, fuzzy memory whilst bringing you one step closer to summer. Either way, no matter what the time of year it's always a time for games. The February Free-For-All means just that ; no set format, no set genre, no limit on games. It's simply going to be a case of plug in, pick up and play. The whole random nature of this should be rather fun, and it's going to an entry-a-day too, so plenty to look forward to.
1990's, 2000's, Bad Games, Gameboy Advance (GBA), Handheld Console, Japanese games, Music, Nintendo, Racing games, Retro Memories, Review
RetroReview : The NES January Classic Part 4
Dateline 29th January 2012
As the cold weather begins to creep in, what better way to warm your hands than on a veritable raging fire of hot NES games. This is the final part of the NES January Classic 2012 and there are still one or two surprises for Retrobear to unearth…..
Even if your old consoles don't work you can always adapt them into something more useful instead
And now the end is near, and we reach, the final few-games-of-the-NES-January-classic. The observant amongst you will notice that once again I have failed to go for the more obvious titles – those being anything with Mario and Zelda in the title, Metroid, Castlevania etc. That is purely because rather than play games that people have played over and over again and been reviewed to shit by literally everyone running their own site and blog, I just want to be a little different.
That's not to say I won't play and review them in the future though………….maybe.
1980's, 1990's, Arcade Conversions, Game Rage, NES, Nintendo, Retro Memories, Review, Sports Games
«12345»...Last »
About RetroSection
The Commodorathon
Russian Roulette of Retro
GameFancier Blogs 2010
Write For RetroSection
Would You Like To?
1980's 1990's 2000's Amiga 500 Amiga 1200 Angry Video Game Nerd Arcade Conversions Atari Lynx Atari VCS Bad Games Buying Car Boot Charity Shops Commodore C16 Commodore C64 Gameboy Advance (GBA) Gamecube GameFancier Blogs Game Gear Game Rage Handheld Console Homebrew Megadrive Movie Games NES Nintendo Nintendo 64 PC Games Platform Games Playstation 1 Playstation 2 Playstation 3 Retro Memories Retro Roulette Review Sega Sega Dreamcast Sega Saturn SNES Sonic Sports Games Top Tens XBOX XBox 360 Y.L.O.D.
RetroBear
RetroBear is an avid collector of Retro Games and Retro Gaming Consoles. He also has a few Retro Computers and a number of Retro Computer Games. At one time a regular writer for GameFancier.com he's an all round decent sort of chap. He also has a beard..
IrishManx on RetroComment : The Demise of GAME – Good or bad news ?
RetroBear on RetroComment : Where's The Originality ?
RetroBear on RetroReview : The NES January Classic Part 4
Geeksleek on RetroComment : Where's The Originality ?
RetroBear's Games Catalogue
RetroGamer.net
"Kong Me Baby", a Donkey Kong Arcade theme by Rotheblog.com | Powered by WordPress
RSS Feeds XHTML 1.1 Top


text:
December 01, 1996; 47 (6) Article
Familial meningocerebrovascular amyloidosis, Hungarian type, with mutant transthyretin (TTR Asp18Gly)
Ferenc Garzuly, Thomas Wisniewski, Ferenc Brittig, Herbert Budka
First published December 1, 1996, DOI: https://doi.org/10.1212/WNL.47.6.1562
Ferenc Garzuly
Thomas Wisniewski
Ferenc Brittig
Herbert Budka
Neurology Dec 1996, 47 (6) 1562-1567; DOI: 10.1212/WNL.47.6.1562
Amyloid deposits in leptomeningeal vessels, subarachnoid, subpial, and subependymal cerebrospinal regions, spinal ganglia, peripheral nerves, and some internal organs (predominantly heart and kidney) characterize a dominantly inherited disease in a Hungarian family.We found four definitely and three probably affected members in this family of 56 persons in four generations. Clinical features in all definitely diseased patients include disturbance of memory, psychomotor deceleration, ataxia, and hearing loss. In most patients there was temporary disorientation, migraine-like headache with vomiting, and tremor. Some patients had nystagmus, pyramidal signs with spastic paraparesis, hallucinations, urinary retention, and obstipation. Single patients had facial tics and sleep disorders. Progressive visual disturbance and clinically manifest polyneuropathy were absent. CSF protein was markedly elevated in all patients. CT showed characteristic symmetric calcification along the sylvian fissure; MRI after contrast administration showed prominent enhancement at the surface of the sylvian fissures, brainstem, and cerebellum. Autopsy data was available in three definitely affected patients and in one unaffected family member. Immunohistochemistry identified the amyloid deposits as of the AF (transthyretin, TTR) type; DNA studies revealed a novel TTR missense mutation at codon 18 (TTR Asp18Gly). According to clinical features, pathologic alterations, and molecular studies, this disease is a novel type of systemic familial amyloidosis with disease manifestation clinically restricted to the CNS. It is similar to the oculoleptomeningeal amyloidoses but can be clinically diagnosed by characteristic CTs and the absence of progressive visual impairment.
NEUROLOGY 1996;47: 1562-1567
Systemic familial amyloidosis frequently affects the peripheral or central nervous system (CNS). In recent years, the molecular characterization of the various deposited amyloid proteins has resulted in a new classification of amyloidoses. [1-3] The most common clinical syndrome associated with transthyretin (TTR) amyloid is polyneuropathy. We report here clinicopathologic features of a novel, extraordinary type of systemic familial transthyretin amyloidosis causing CNS disease in a Hungarian family. Uemichi et al. [4] reported in 1992 a family of Hungarian descent living in the United States with mutant TTR (ARG 10), but the disease was associated with familial polyneuropathy. Clinical and pathologic features of our patients show similarities to oculoleptomeningeal familial amyloidosis (OLMA) [5-8] but were different in several respects.
Case reports.
Family history.
Early in 1991, a middle-aged woman was admitted to our neurological department with temporary disorientation. CTs showed symmetric calcification of the cortex along the sylvian fissure. The cerebrospinal fluid (CSF) protein level was markedly increased. Three years earlier, the CT of a female patient with a similar high CSF protein level disclosed the same change. They were first cousins, and the father of one and an uncle of both patients had died in our department many years before and had undergone autopsy. New histologic sections were made from stored paraffin blocks and examined. In the interval, the first of our female patients died; histology showed systemic amyloidosis. Compilation of the family history resulted in a pedigree (Figure 1) that covers 56 persons in four generations. Most members of this family had lived for a long time in the surroundings of Szombathely, Hungary.
Figure 1. Family pedigree.
Patient 1 (II-6 in Figure 1).
(Figure 1) He was admitted to the neurological department six times between 1938 (at the age of 36) and 1960. On each admission, he complained of severe headache, nausea, and vomiting, sometimes with transitory diplopia. At first admission, there was partial loss of hearing in his left ear. Best corrected visual acuities were 20/30. The patient had severe myopia (-5.0 dpt) and astigmatism. At repeated examinations, no alterations on the cornea or in the fundus were found. He developed vertical nystagmus, limb and trunk ataxia, intentional tremor, hyperreflexia and pyramidal signs, and, later, urinary retention and constipation. He became confused during an attack of severe headache.
The CSF protein level was markedly increased (103 mg/dL [1.03 g/L]) and rose to 330 mg/dL (3.30 g/L) by the end of his illness. The lateral ventricles, the third ventricle, and the proximal part of the sylvian aqueduct were enlarged on ventriculography.
Twenty-two years after his first admission, at the age of 58, he was readmitted because of headache and vomiting, and developed fatal pulmonary edema.
At autopsy, the brain weighed 1,230 g. Coronal sections showed ventricular widening. Histologic investigation disclosed granular ependymitis. Bronchopneumonia and congestion of the internal organs were noted. Unfortunately, tissue blocks were not available for reexamination.
(Figure 1) He was hospitalized eight times between 1955 (at the age of 37) and 1971. Before his first admission, his left ear began to buzz, and he became completely deaf within 3 days. He complained of marked dizziness, had horizontal nystagmus, and his gait was unsteady. His fingers trembled. Two years after the onset of the disease, marked spastic paraparesis was noted with hyperreflexia and pyramidal signs. Absence of responses was observed on caloric stimulation. Later, he developed audiovisual hallucinations. He had frequent vomiting, constipation, and urinary retention. Intermittent ocular ptosis was observed in the left eye; he had facial tics on the right side. He had psychomotor slowing and disturbed memory.
Routine laboratory blood and urine tests were always normal. The protein level of the CSF increased progressively to 920 mg/dL (9.20 g/L), causing xanthochromia. The CSF cell count was up to 127/mm-3 (127 [centered dot] 106/L); glucose was always normal.
He was repeatedly examined by ophthalmologists, but no pathologic changes were found. There was ventricular enlargement on pneumoencephalograms. During the last period of the disease, the electroencephalogram showed generalized theta and, on the left side, periodic delta waves. He died at the age of 53, after 16 years of illness.
At autopsy, pneumonia was found. The brain weighed 1,200 g. The surface of the pia was rusty brown. The inner wall of the ventricles was unevenly rough. Histologically, the thickened leptomeninges showed homogeneous material deposited mainly subarachnoidally and subpially in the sylvian fissure, around the brain stem and the spinal cord. The deposited material was rusty brown after staining with Congo red and showed green birefringence under polarized light. The adventitia of the medium- and largesized arteries and the walls of the smaller arteries, arterioles, and veins were thickened and homogeneous. The vessel-wall abnormality was restricted to meningeal vessels. Deposition of homogenous, lamellar, or spotty material was observed also subependymally. The lumen of the sylvian aqueduct was narrowed. There were no senile plaques in Bielschowsky preparations.
Patient 3 (III-14 in Figure 1).
(Figure 1) She was first admitted in 1984, at the age of 53. Before her admission, she had not been able to answer questions on repeated occasions and later did not remember them. She was unsteady in Romberg position. Laboratory findings were normal. Hypertensive retinopathy was present. The CSF lymphocyte count was 2/mm (-3) (2 [centered dot] 106/L), the protein level was 340 mg/dL (3.40 g/L), and the glucose level was 70 mg/dL (3.8 mmol/L). Electroencephalography showed diffuse slowing. No pathologic changes were seen on her angiograms. She was hospitalized for the second time 4 years later. Headache and repeated vomiting had developed. She had been unable to perform housework; she slept much during the day and walked unsteadily. Neurologic examination revealed moderate ataxia of limbs and trunk. Visual acuity corrected to 20/20. The visual field was normal. Her intelligence quotient (Wechsler) was 81. The CSF was xanthochromic, and the protein level was 440 mg/dL (4.40 g/L). The audiogram showed bilateral perceptive hearing loss. In the electroencephalogram, moderate left parietal slowing and bilateral disorganization were seen. CTs of the head showed normally sized ventricles; the cortex was hyperdense in ribbon-like fashion symmetrically along the sylvian fissures (Figure 2). T1- and T2-weighted MRI sequences showed no alterations; contrast was not administered. Thus, the intensive enhancement at the cerebral surface around the sylvian fissures as seen in patient 4 (III-16 in Figure 1) (Figure 3) was not recognized in this patient. Before the third admission, a histologically proven melanoma had been excised from her back. The last time, she was admitted to the psychiatric department because of anxiety, disorientation, and auditory hallucinations. She died unexpectedly at home after 7 years of illness, at the age of 60.
Figure 2. CTs of patients III-14 and III-16, showing symmetric calcification in the cortex along the sylvian fissure.
Figure 3. Patient III-16. T1-weighted MRI sequence shows intensive enhancement of the administered contrast medium at the surface of the medial temporal lobes and sylvian fissures.
At autopsy, the brain weighed 1,000 g. Granulated depositions in the subarachnoid space in some places above the hemispheres and around the brain stem and spinal cord thickened the leptomeninx and gave it a rusty brown color. There was a pinhead-sized metastasis of the melanoma in the left nucleus caudatus. Metastases were found in most internal organs (lungs, kidneys, liver, spleen). The cause of death was pulmonary embolism.
Extensive patchy or plate-like homogenous deposits were seen subpially (Figure 4) and subependymally (Figure 5). They stained rusty-brown with Congo red (see Figure 5), displayed green birefringence under polarized light, and were immunocytochemically labeled with an antibody against TTR. Next to the amyloid, there were extensive calcifications in the subpial space along the sylvian fissure (see Figure 4) and in the parahippocampal gyrus. The walls of the leptomeningeal small arteries, arterioles, and veins were thickened by amyloid deposits. In large arteries, amyloid deposition was limited to the advential layer. In Bielschowsky preparations, no senile plaques were found. Marked amyloid deposits were seen in spinal ganglions (Figure 6) and in spinal roots, moderate in sciatic nerve.
Figure 4. Patient III-14. Extensive subpial calcifications (black deposits) next to amyloid deposits (gray deposits, arrows) along the sylvian fissure. Hematoxylin and eosin stain. Magnification x100, before 24% reduction.
Figure 5. Patient III-14. Prominent subependymal amyloid deposits (dark). Congo red stain. Magnification x100, before 10.2% reduction.
Figure 6. Patient III-14. Amyloid deposits in lumbar spinal ganglion (dark gray amorphous material). Hematoxylin and eosin stain. Magnification x120, before 32.7% reduction.
Examination of internal organs revealed additional amyloid deposits: in the heart in interstitial tissue; in the kidney in interstitial tissue as well as perivascularly and in glomeruli; and in the skin in interstitial tissue of the corium and perivascularly but not in the glands. Moderate deposits were seen in the lungs (perivascularly and interstitially), and minimal perivascular deposits were seen in the liver.
(Figure 1) This 51-year-old woman was admitted in 1991. She was dismissed from an executive position in her office because she became unable to function reliably. Just before her admission, an attack of disorientation was observed. Her hands and head had been slightly trembling for 2 years, and her gait was mildly ataxic. IQ (Wechsler) was 110 in 1991 and 90 in 1995. Major abnormal laboratory findings were not present. The CSF cell count was 5/mm-3 (5 [centered dot] 106/L), protein level was 820 mg/dL (8.2 g/L), and glucose level was 60 mg/dL (3.4 mmol/L); albumin 0.385 g/dL (3.85 g/L), IgG 52.5 mg/dL (0.525 g/L), IgG/albumin index 0.73, local IgG synthesis 0.65 mg/dL (0.0065 g/L) with oligoclonal gammopathy. The optic fundi were normal. Corneal opacity caused by herpes zoster was present in the right eye. The audiogram showed bilateral sensory-neural hearing loss. CTs showed symmetric hyperdensity of the margin of the cortex along the sylvian fissure. T1- and T2-weighted MRI sequences after contrast administration showed intensive enhancement at the surface of the medial part of the temporal lobes, the sylvian fissures (see Figure 3), the brain stem, and the cerebellum. The electroencephalogram disclosed decreased background activity. EMG and ENG, acoustic and visual evoked potentials were normal. At present, her condition has deteriorated only slightly.
Relatives possibly afflicted with the same disease.
Patient 5 (female, I-2 in Figure 1).
(Figure 1) The mother of two definite patients (nos. 1 and 2) and two possible patients (nos. 6 and 7) died at the age of 45 after having shown some neurologic symptoms; her death was attributed to "Spanish flu."
Patient 6 (female, II-2 in Figure 1).
(Figure 1) She died in the National Institute of Psychiatry in Budapest at the age of 40, in 1948. According to her relatives, she had been treated for "madness."
Patient 7 (male, II-5 in Figure 1).
(Figure 1) He died at home at the age of 51 because of suddenly developing hemiparesis.
Immunohistochemical and DNA studies.
Data are presented in detail elsewhere. [9] In brief, paraffin sections of frontoparietal cortex and from kidney and peripheral nerves of patients II-7 and III-14 were subjected to immunohistochemical staining. Amyloid deposits were immunoreactive with antibodies to TTR, apoE, and amyloid P component in CNS, kidney, and peripheral nerves. They did not react with antibodies against A beta, prion protein, amyloid A, cystatin C, gelsolin-related amyloid, light chain, amylin, and fibrinogen.
Total genomic DNA was isolated from peripheral blood leukocytes of patient III-16 and healthy family member III-11, as well as from fixed, paraffin-embedded tissue from patients II-7, III-14, and III-18 (46-year-old patient, died in 1993; amyloidosis excluded by detailed autopsy; clinicopathologic diagnoses; chronic alcoholism, liver cirrhosis, diabetes mellitus, pneumonia). In addition, genomic DNA was isolated from the peripheral blood of 40 control individuals. Only one base difference was detected in the gene as compared with the previously determined normal TTR gene sequence in affected family members. The presence of G instead of A at the second base of codon 18 resulted in the conversion of Asp to Gly.
We describe unique clinicopathologic findings in four definitely affected adult members of this Hungarian family with a long-lasting (range, 4 to 22 years) dominantly inherited disease.
Ages at onset were 36, 37, 51, and 53. Besides transitory symptoms of migraine-like headache, vomiting, dizziness, and disorientation (with transient global amnesia), the major signs were hearing loss, ataxia, and impairment of memory that worsened progressively. Additional neurologic signs or symptoms were nystagmus, spastic paraparesis, intention tremor, hallucinations, dementia, urinary retention and constipation, sleep disorder, and facial tics.
In two recent patients, CTs revealed strikingly similar symmetric hyperdensities along the sylvian fissure. Marked calcification next to massive amyloid deposits was the pathologic substrate of these alterations on CTs. In one case, MRI showed prominent enhancement after contrast administration at the same site. Another characteristic feature was high protein content in the CSF, which became xanthochromic in the final stages of the disease in two patients.
Three patients died at ages 53, 58, and 60. Autopsy revealed systemic amyloidosis. However, amyloid deposits predominated in cerebrospinal leptomeningeal vessels and in subpial and subependymal regions. The brain parenchyma was not involved. Deposits also involved spinal ganglia, peripheral nerves and skin, and, among internal organs, predominantly heart and kidney.
On the basis of clinical findings, our cases do not resemble the classical types of familial amyloid polyneuropathies (FAP), the disease usually associated with TTR amyloid, where all patients have peripheral nerve disorders without CNS dysfunction [10] although the CNS may harbor amyloid deposits, as recently described in some pathologically examined cases of FAP type I. [11,12] Our patients had no symptoms of polyneuropathy despite some deposits in ganglia and nerves at pathology.
Familial cerebral amyloid angiopathy [13,14] is not associated with systemic vascular amyloidosis nor with any form of peripheral neuropathy. Other types of cerebral amyloidosis, including the most common beta/A4 deposition in Alzheimer disease, [15] are also distinct.
The only form of familial amyloidosis that exhibits similarities to our family disease is primary amyloidosis with vitreous opacities, also termed "oculoleptomeningeal amyloidosis" (OLMA). [2,5-8] In this form, patients have mainly ocular and CNS involvement. An ocular manifestation, vitreous opacity, is the only manifestation occurring in nearly all patients. Features in common with our cases are high CSF protein levels, systemic amyloid deposition, histologic involvement of both CNS and PNS, and localization of deposits in leptomeningeal vessels and in the subpial and subependymal regions. Another similarity is the deposits in internal organs although they do not cause clinical symptoms. Both diseases start at the same age, may last for decades, and have an autosomal dominant pattern of inheritance.
The differences between the two diseases are as follows: Disturbed visual acuity is often the first sign of OLMA where there are abnormalities in the vitreous body and retina [5]; none of our patients had similar abnormalities. Cranial CTs in OLMA patients [6,7] did not reveal symmetric calcifications along the sylvian fissure, as in our cases. Our patients did not have cerebral infarction or hemorrhage; they occur in OLMA, although not frequently.
Uitti et al. [7] reported the type of amyloid in OLMA patients of one kindred as "anomalous transthyretin" by analysis of blood samples, but provided no further methodologic details. Petersen et al. [8] recently described a new family with OLMA associated with a G30V mutation of TTR that differs clinically from our family by visual deterioration. It is still enigmatic how distinct missense mutations of TTR, and of other widely expressed amyloidogenic proteins, cause distinctive systemic or organ-specific amyloid deposition and damage in such a varied phenotypic spectrum. In conclusion, familial meningocerebrovascular amyloidosis, Hungarian type, should be added to amyloidoses with disease manifestation in the CNS.
The authors are grateful to Dr. Z. Molnar, Department of Radiology, Markusovszky Hospital, Szombathely, and to Dr. I. Repa, Pannon Agricultural College, MRI Laboratory, Kaposvar, for permission to use Figure 2 and Figure 3, and to Mrs. H. Flicker (Vienna) for excellent technical assistance.
Copyright 1996 by Advanstar Communications Inc.
Frangione B. Systemic and cerebral amyloidosis. Ann Med 1989;21:69-72.
Duchen LW. Current status review: cerebral amyloid. Int J Exp Path 1992;73:535-550.
Murakami T, Uchino M, Ando M. Genetic abnormalities and pathogenesis of familial amyloidotic polyneuropathy. Pathol Intern 1995;45:1-9.
Uemichi T, Murrell JR, Zeldenrust S, Benson MD. A new mutant transthyretin (Arg 10) associated with familial amyloid polyneuropathy. J Med Genet 1992;29:888-891.
Okayama M, Goto I, Ogata J, Omae T, Yoshida I, Inomata H. Primary amyloidosis with familial vitreous opacities. Arch Intern Med 1978;138:105-111.
Goren H, Steinberg MC, Farboody GH. Familial oculoleptomeningeal amyloidosis. Brain 1980;103:473-495.
Uitti RJ, Donat JR, Rozdilsky B, Schneider RJ, Koeppen AH. Familial oculoleptomeningeal amyloidosis. Arch Neurol 1988;45:1118-1122.
Petersen RB, Tresser NJ, Richardson SL, Gali M, Goren H, Gambetti P. A family with oculoleptomeningeal amyloidosis and dementia has a mutation in the transthyretin gene [abstract]. J Neuropathol Exp Neurol 1995;54:413.
Vidal R, Garzuly F, Budka H, Lalowski M, Linke RP, Brittig F, Frangione B, Wisniewski T. Meningocerebrovascular amyloidosis associated with a novel transthyretin missense mutation at Codon 18 (TTR D18G). Am J Pathol 1996;148:361-366.
Reilly MM, King RHM. Familial amyloid polyneuropathy. Brain Pathol 1993;3:165-176.
Takahashi K, YI S, Kimura Y, Araki S. Familial amyloidotic polyneuropathy type 1 in Kimumato, Japan. Hum Pathol 1991;22:519-527.
Uishiyama M, Ikeda S, Yanagisawa N. Transthyretin-type cerebral amyloid angiopathy in type I familial amyloid polyneuropathy. Acta Neuropathol (Berl) 1991;81:524-528.
Luyendijk W, Bots GTAM, Vegter van der Vlis M, Went LN, Frangione B. Hereditary cerebral haemorrhage caused by cortical amyloid angiopathy. J Neurol Sci 1988;85:267-280.
Haan J, Algra PR, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis-Dutch type. Arch Neurol 1990;47:649-653.
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 1985;82:4245-4249.


Microsoft's Cortana is now available in India which is a newly added best feature for Windows 10 users. Cortana is a personal digital voice assistant, in simple words, it is an app that provides you to do anything on your mobile or PC just by giving commands using your voice. Till now, this feature is only available for Windows 8.1 users and now Microsoft announced that it rolling out Cortana to India and three other regions via Windows 10 Insider Preview who are on the build 10532 and higher versions. Here is a complete guide about Cortana, it's features, working procedure and how to update or enable it on Windows 10. Have a look!
How to Update Cortana on Windows 10?
Cortana is a Personal digital voice assistant, which is just like your silicon secretary who can help make your life easier. Cortana is a Microsoft launched app for the Windows users of both PC and Mobile devices. Cortana can do everything which is similar to other voice control apps like Siri and Google Now. Cortana is an app that does all your work on your device only through your voice. It follows the commands given by the user through their voice.
Cortana reduces your search for things on your mobile device or PC, so that you can do your work with much ease. Instead of searching for things by yourself, you can ask Cortana so that it will give whatever information you require on your device. Suppose, if you wish to make a call to your mom, then you need to tell it to Cortana as "Call mom" and it listens, understands your voice and makes a call to your mom. Not only making a call, it can also set a reminder for you, set an alarm, send a text message and many more.
Tracks and records your every move and can respond to all relative questions.
Cortana was earlier available for the Windows 8.1 users and now Microsoft introduced the personal digital voice assistant to the desktop platform with Windows 10. It is now available in India, Japan, Australia, and Canada to Windows Insiders as an optional download for the users who have participated in the Windows Insider program. The users must be on the latest Windows 10 Insider Preview build 10532 and higher versions. The new feature of Cortana on Windows 10 is more comprehensive and it offers numerous languages than before that includes Bulgarian, Swedish, Korean, Japanese and Klingon.
As Cortana is available in India for all the users of Windows 10 Insider Preview who has build 10532 and above versions. Here is a simple way of how to enable Cortana on your Windows 10. You need to just follow the below given steps and try to enable it on your device. You can enable this feature only on your Windows Technical preview.
Step 1: In order to use Cortana, you need to create a Microsoft account.
Step 2: After successfully creating a Microsoft account you can now use Cortana on your device.
Step 3: To activate Cortana, initially press and hold the search key on your Mobile device. If you're using a PC, just click on the search box located in the Taskbar.
Step 4: When the search windows displays on the screen, click on Notebook icon present on the left side of the window.
Step 5: Now, Click on Settings from the list of Notebook options.
Step 6: Under the Settings Window, you can see a button to enable Hey Cortana. Toggle the button towards the ON position.
Initiate by saying "Hey, Cortana," which is followed by your command given through voice.
You have to give any command as soon as the Cortana activation prompt.
Then it indicates listening and performs that particular task.
Step 8: That's it, you can now start using your Personal Digital voice assistant, Cortana.
This is all about Cortana – your Personal digital assistant that is now available on your Windows 10 operating system. Now, you can update Cortana on Windows 10 as it is now available in India and start using it so as to ease your life. Hope this tutorial guides you to know everything about Cortana, it's features and steps to update it on your Windows 10. Enjoy using Cortana!


text:
Friedrich Schröder (* 29. März 1775 in Bremen; † 3. Oktober 1835 in Bremen) war ein Kaufmann und Reeder in Bremen und ließ das erste von einem deutschen Schiffbauer konstruierte Dampfschiff, Die Weser, bauen.

Biografie

Schröder wuchs in Bremen auf. Er war Kaufmann und dann Bevollmächtigter im Bereich einer Assekuranz-Kompanie und Heringsfischerei. Er entwickelte Anfang des 19. Jahrhunderts die Idee, die schlechten Fahrwasserverhältnisse der unteren Weser durch den Einsatz von Dampfschiffen zu überwinden. 1816 beantragte er beim Bremer Senat die Konzession für eine derartige Unternehmung für 25 Jahre. Er erhielt das Privileg am 18. Juni 1816 zum Betrieb von Dampfschiffen auf der Weser allerdings mit einer Laufzeit von nur 15 Jahren. Als er auch von den Regierungen in Oldenburg und Hannover die gleichen Rechte erhielt, konnte er mit dem Bau beginnen.

Nachdem Pläne, ein Dampfschiff in England oder Schottland zu erwerben, fehlgeschlagen waren, beauftragte er die Werft von Johann Lange mit dem Bau. Der Mechaniker Ludwig Georg Treviranus (Bremen), der Kapitän Zacharius Spilker und Johann Lange absolvierten auf Schröders Veranlassung eine Studienreise nach England, um Kenntnisse im Dampfschiffbau
zu sammeln. Nach Rückkehr dieser Fachleute wurde mit dem Bau begonnen. Am 30. Dezember 1816 erfolgte der Stapellauf und kurze Zeit später der Liniendienst auf der Weser.

Auch das Dampfschiff konnte den widrigen Flussverhältnissen nicht viel entgegensetzen, und so blieb Schröders Unternehmung überwiegend unwirtschaftlich. Ein zweites Dampfboot, die Herzog von Cambridge, wurde 1818/19 bis 1830 in Betrieb genommen. 1833 wurde der Verkehr eingestellt. Bis dahin wurden insgesamt 83.291 Passagiere befördert.

Neben seiner unternehmerischen Tätigkeiten war Schröder Mitglied in der Gesellschaft Museum. - Friedrich Schröder war mit Regina Margareta, geb. Droop (1783–1839) verheiratet, der Tochter des Bremer Kaufmanns Heinrich Droop.

Ehrungen

Die Friedrich-Schröder-Straße () im Bremer Ortsteil Vegesack wurde nach ihm benannt und war der damaligen Bau- und Startpunkt seines Dampfschiffs.

Literatur
 Georg Christian Kindt: Die erste Dampfschifffahrt auf der Weser und ihr Begründer, Friedr. Schröder. In: Naturwissenschaftlicher Verein zu Bremen (Hrsg.): Abhandlungen. Band 1. C. Ed. Müller, Bremen 1868, S. 329–344 ().

Weblinks
 books.google.com/books/pdf/Abhandlungen__naturwissenschaftlichen_Ve.pdf PDF-Version des Buches Abhandlungen des Naturwissenschaftlichen Vereins zu Bremen mit dem Kapitel Die erste Dampfschifffahrt auf der Weser und ihr Begründer Friedrich Schröder

Siehe auch
 Ludwig Georg Treviranus

Kaufmann
Reeder (Bremen)
Deutscher
Geboren 1775
Gestorben 1835
Mann


text:
Interview with Andrey Vladimirovich Bokov. Anatoly Belov
The text of interview for the catalogue of Russian pavilion of XI Venetian biennial
Anatoly Belov
Andrey Bokov
Andrey Vladimirovich, the first question I would like to put to you is: Do you think it's right today to contrast the Russian architectural school with foreign architecture? Do you agree with the division into ours and not ours, into Russian architects and foreign invaders, on which the concept for the Russian pavilion at the Venice Biennale is based?
It's a legitimate view to take, given there is a reality which sustains it. But, at the same time, if it's possible to name – admittedly, not without omissions and reservations – the distinctive characteristics of the Russian architectural school, it would clearly be an exaggeration to speak of Western architecture as an integral system, and still less as a system opposed to modern Russian architecture. The division into ours and not ours is always a delicate matter. Our fellow Russians often see relations between Russia and the West as more tense than they actually are. Foreigners, at any rate, are rather less concerned about this subject. Personally, I think it more reasonable to posit a division into 'outsiders' and 'natives'. Which is to say, I'm inclined to distinguish architects not in terms of nationality, but according to what approach they take to the profession. I regard as 'outsiders' those who consciously or unconsciously ignore the distinctive features of our cultural context – those whose activities are to one extent or another dangerous for our national culture. 'Natives' are, accordingly, those who have found their place in the context and merged with it. Traditionally shocking are the results of competitions involving foreign top-name architects and the solo performances of these celebrities in our country, in both of which blatant disregard for Russian culture is common. But at the same time we should not forget the great damage sometimes done to Russian cities and architecture utterly without intervention from abroad.
The current fears and phobias, a reaction to the increased activity of foreigners in our architectural market, have roots that are cultural, political, and historical. They go back to the end of the 1930s, when all links with the outside world were broken off and we were left to stew in our own juices.
What about Albert Kahn, who during those same 30s designed industrial buildings for half the USSR?
Kahn wasn't alone; there was a whole horde of them. But they were all thrown out of the USSR in a single instant, in spite of the fanatical loyalty that many of them showed to the communist idea. One of the last episodes of collaboration with foreigners at that time was the heroic effort made by the Vesnin brothers to bring Le Corbusier to the Soviet Union… Essentially, they ceded to him the right to design Centrosyuz. However, the latter project ended in a scandal, with Le Corbusier renouncing his authorship of the building. After that, we went our own way.
But the coup de grace was delivered to Russian culture by Khrushchev with his 'Resolution on Superfluity in Architecture'. It was then that architecture was altogether excluded from the category of art and completely subordinated to construction.
The above catastrophes had such an impact on the architectural profession in this country that we are still living with their consequences.
Which is to say, you base your evaluation of the influx of foreign specialists into Russia on historical premises and consider this a broadly positive tendency? We learn and they teach, is that right?
The main thing here is probably that our relations with foreigners are cyclical in character. Periods of love for and hatred of the West replace each other strikingly quickly and – and this is the funniest thing – independently of state policy. A blend of xenophobia and 'veneration of the West' is a paradox of our mentality which rules out working normally with foreigners or objective evaluation of what they do.
In addition to all the above, foreigners anyway come in different kinds. The foreigners who come here may be stars or simply professionals, but they may also be people who can teach us nothing. Visits from the first group are a blessing. Visits from the last – I would call them opportunists – are probably the norm, something that cannot be avoided. The main thing, in the final analysis, is that between us there should be that trust which is necessary between members of the same profession.
There are two ways of looking at this. You can regard the presence of foreigners here either as a potential source of conflict or as helping our integration in the global process. Probably, it's both. How do you see your part in this process?
Unlike many people, I don't see foreigners as aliens. I don't have any complexes in this respect. They and I speak the same language. It's another matter that I have a much deeper knowledge of life in Russia than they do: I would never propose what Perrault proposed for the Mariinsky Theatre or Kurokawa for the Kirov Stadium [in St Petersburg]. The latter two projects are utterly unviable. In all this I see the wrong attitude being taken to the brief… Which is strange, given that this is not typical for specialists of this class. Both the Mariinsky and the Kirov Stadium projects are full of irrational, contrived solutions whose inappropriateness will be all the more apparent at each successive stage of the design process. These solutions will not be realized.
The Mariinsky and the Kirov Stadium are possibly exceptions, the result of an insufficiently serious approach. In ordinary practice, people such as Perrault and Kurokawa don't make mistakes; they do everything perfectly professionally.
In both cases I think the jury's decision was based not on analysis of the projects, but on subjective feelings, on an a priori trust in artistic and charismatic foreign celebrities and on a profound scepticism – common among bosses and oligarchs today – with regard to Russian specialists, who tend to be looked upon as still inescapably Soviet or provincial. So I see my own role in setting straight our relations with our foreign colleagues as one of overcoming these views.
Am I right in thinking that in spite of the above particular instances, you are nevertheless generally in favour of integration with foreigners? Why? Is it a matter of solidarity? As far as I know, there was a time when you too were active in trying to get into foreign markets – in China and Germany. This makes you likewise a kind of invader.
Yes, I was once very interested in foreign competitions… However, this is not at all the reason why I have sympathy for foreign architects. About ten years ago, we did a lot of work for both the Chinese and the Germans. But our designs were never realized. Penetrating a foreign market is a time-consuming, troublesome business, and then no one particularly wants you to build in their country. It would have been necessary to concentrate fulltime on these projects, open offices there, invest large sums of money. Literally move there. That's how all the Western firms operate when they work abroad. In our case this was no invasion but a series of one-off commando drops. We had neither the resources nor the time for a serious campaign and, even more importantly, there was work for us here. Europe is now in the grip of a recession. Construction work there has finished. There's no work and everyone has rushed off to Asia and Russia. So I'm glad I live in Russia, where there's theoretically enough work for everyone.
It's currently fashionable to divide Russian architects into traditionalists and followers of the West. In tribute to this fashion, I would like to ask you which party you would put yourself in?
To be honest, I don't find this division very comprehensible. It takes us back to the question of style, which seems to me considerably more fundamental than that of quality. Many people naively think that adherence to a certain style can guarantee success, when in fact success in our profession is guaranteed by something else altogether. I was amazed when I discovered archaic, historical motifs in works by vehement members of the Avant-garde such as Picasso, Mel'nikov, and Le Corbusier. These people worked outside all stylistic categories; they were each to himself – it was only later that critics began to associate them with this or that group. Or remember the surprising blend of Constructivism and Art Deco in the 1930s. Style does not play such an important role in architecture as people often think. For some people not belonging to a 'party' in terms of style is a sign of a lack of principles… But not for me.
The main thing is that a building should be worthy.
I'm more fond of the word 'appropriate', although 'worthy' is also a good word. These words are a good reflection of my attitude to architecture in general. You should understand that 90% of our commissions come from the Government of Moscow. We, Mosproekt-4, are a municipal organization that carries out commissions from the city. We, for example, cannot not react to the desire of the city's management and the management of the Tretyakov Gallery to see the New Tretyakov building designed in the 'Vasnetsov style' – in, roughly speaking, the Russian version of early-20th-century Art Nouveau, a style that is slightly provincial, fragmentary, naïve. It's not something I feel very close to. I have an idea of this style and how to work with it, but consider it best to use an artist who could be the Vasnetsov or, even better still, the Lentulov of our time. It would be great if this role could be carried out by a person as sensitive and delicate as Ivan Lubennikov, whom I've invited to take part and whom I see in the role of creator of this façade. This is a permissible approach, and one which I see as reasonable and ethically justified.
While we're on the subject of style, your projects are stylistically very diverse, especially those from the last few years. Is there a theme that runs right through your work?
I suppose there must be. But what do you mean?
Well, for instance, the 'sail house' on Khodyynsk Field is stylistically very different, in my opinion, from the Ice Palace of Sport, which stands in the same district and is to be exhibited at the Venice Biennale this year. And your maternity hospital in Zelenograd is a detour towards Constructivism – a third style.
Architects are like writers. There are people who spend their whole life writing a single novel – usually about themselves. And there are those who write poetry, prose, and plays all at the same time while looking at the world around them and allowing themselves both to doubt and get excited and yet remaining themselves. Some have found and others are looking, looking for images and spaces. I am always slightly suspicious of the artificiality and sterility of a person's life when he or she spends it following the same line, like a clockwork mechanism, and sings one and the same song. I can understand Le Corbusier, but not Richard Meier, who took one of Corbusier's buildings and, like a good pupil, produced numerous interpretations and reproductions… The borders between styles were eroded altogether by the efforts of the Postmodernists in the 70s. The very concept of style, in my opinion, has lost its point. What remains is a publicly accessible set of media of artistic expression, which could and must be used. Although, personally, I'm a little disturbed by the heightened sensitivity to these media, to décor in particular, shown by both the general public and professional architects.
For me the essentially important thing is something else: space as such. Emptiness, which the architect must organize.
Furthermore, I have to repeat myself here, we are a municipal organization. You should understand that a state commission involves a huge number of planning approvals, continual dialogue with the authorities, and attendance of endless council sessions. And the only path to salvation lies through a spatial solution in which expressive media are secondary.
Spatial – in the sense of urban planning?
Partly, yes. Urban planning was how our generation entered the profession, in the same way that the next generation was shaped by 'paper' competitions. It's widely accepted that the history of Modernism ended at the end of the 1960s, and that its final chord consisted of extremely productive, radical, and content-rich urban-planning concepts. Until the 1960s architects mostly dealt with single buildings. The urban-planning solutions proposed by Le Corbusier, say, were considerably more naïve than the houses he designed. It was only with the arrival of Team Ten and the Smithsons, who took a qualitatively different approach to the city, that we started to see multi-functional structures, a new feeling of urban space, and the idea of integrating architecture and urban planning. This was an utterly intuitive and yet quite deliberate movement, which mixed artistic media and languages with rational constructions and methods. Architecture was seen at the time as inseparable from urban planning and layouts. This is why I'm saddened by the decline in urban-planning culture and the complete indifference of society and state to the unique instruments which only architects possess for organizing Russia's endless spaces.
On the subject of municipal commissions. Can I ask you a question from left field? How do you manage to combine your work as an architect with your functions as an administrator, academic, and researcher? You are head of Mosproekt-4, a member of the Russian Academy of Architecture and Construction Science, and the author of two books and more than 50 articles.
I don't know how I do all this. There's just no alternative. But it's clear that I spend most of my time on activities that have no direct relation to architectural design. But were I not to pay proper attention to these activities, I would not be able to fight for our right to individual solutions. That goes for all architects. It's another matter that many try their best to disguise these managerial gifts, preferring to seem 100% creative figures. They pretend to be artists, although they carry an arithmometre in their heads. It's like Governor Brudasty from Saltykov-Shchedrin's History of One Town, who has an organ fitted in his head. Success in this profession largely depends on having such an organ. But, of course, it's also a matter of what you prioritize: what is primary for you – management or architecture?
Over the last 10 years you have worked with a huge number of people. The former 'paper architects' Dmitry Bush and Sergey Chuklov are part of your team. You worked with Boris Uborevich-Borovsky on the 'sail house' on Khodynka. How do you manage to find a common language with so many different people?
With each of these people, as with many others, I have shared years of working together and joint failures and successes. In general, I'm very proud of those who work in our institute. And for me the most precious thing is that they have themselves chosen to work here, in spite of the discomfort which often accompanies working on state commissions. These are people of a certain type, who are sincerely and thoroughly devoted to their profession.
Are you happy that of all your many designs it was the Ice Palace – the so-called Mega-arena – that has been chosen for the Biennale?
Well, that was the curator's choice. I think he based his decision on the fact that this project is very different from all other modern buildings with similar functions. The current fashion is for enclosed and impenetrable heaps or drops. Like the Allianz Arena in Munich. You know, when you wander around it, you have no idea where north and south are, how to get in or how to get out. Mega-arena is an open structure. It's completely different. And, I think, much more honest and appropriate.


text:
PSY3230
Browse areas of study
Search Handbook
by area of study
by school, department, centre
by Monash Passport
by off-campus
by admin unit (staff only)
Undergraduate - UnitPSY3230 - Forensic psychology
Faculty Faculty of Medicine, Nursing and Health Sciences
Organisational Unit School of Psychological Sciences
Offered Not offered in 2014
Coordinator(s) TBA
This unit focuses on ways in which the fields of psychology and law interact, in particular the application of scientific and professional aspects of psychology to issues concerning the law and legal systems. Topics to be covered include theories of criminal behaviour, assessment of fitness for trial, criminal responsibility, treatment of mentally ill offenders and forensic patients, violence and risk assessment, confidentiality, eyewitness testimony, jury decision making, psychological assessment of injured persons, involuntary commitment and expert witness testimony. Students will also undertake in-depth research of a specific subject matter relevant to the field of psychology and law.
Upon successful completion of this subject, students will have acquired an understanding of:
a. the application of psychological principles and research methods to the legal system, legal process and policy;
b. ways in which psychologists may be involved in the legal system; and
c. principles of law which are relevant to the field of psychology, in particular the notions of mental impairment and criminal responsibility.
Students will develop skills in the critical evaluation of forensic psychology research and theories.
Students will have acquired competence and generic skills such as written and oral communication of psychological research and theory in the legal context, group and team management in carrying out group research, and critical thinking and analysis in the preparation of an individual research paper.
Multiple choice exam (2 hours) (60%)
Critical appraisal of current theoretical and research literature (2,000 words) (40%)
Hurdle: Students must pass the examination to achieve a pass for this unit
Dr Joanne Fielding
Two x 1 hour lectures and one two hour tutorial each week. For each week during the semester, students will be expected to complete the equivalent of 2 hours preparation for each lecture, 2 hours preparation for each tutorial and 2 hours of research work/independent study (total = 12 hours study).
PSY1011, PSY1022, PSY2051.
PSY2042.
PSL3072, PSY3142.
Additional information on this unit is available from the faculty at:
http://www.med.monash.edu.au/psych/course/ugrad/major-minor.html


Characteristics of shoulder joint arthralgia (arthrosis): It is a degenerative joint disease. Arthralgia primarily affects the articular cartilage; after it is damaged, bone spurs may grow on the edges of the joint. Secondarily, arthralgia may also damage the ligaments and soft tissues around the joint. Such damage leads to joint deformation, limitation of mobility, and pain. Ageing, congenital changes in the joints, traumatic changes, overexertion and metabolic effects are among the factors that contribute to the development of arthralgia (shoulder arthrosis). Complex treatment is required, including medications, surgery, corrective treatment, rehabilitation and spa procedures.
This is one of the basic diagnoses for the use of low-frequency pulsed magnetic therapy. It is successfully used due to its analgesic, anti-swelling, anti-inflammatory and healing effects. Magnetic therapy helps improve mobility and slow down further damage to the joints in chronic patients, and provides overall pain relief.
In arthralgia (shoulder arthrosis), magnetic therapy is applied using the special shoulder applicator. Initially, we preferably use treatment to manage pain at low frequencies of 4-6 Hz, and once pain reduction is achieved, the treatment can be combined with regenerative programs from 25-50 Hz.
In the winter of 2002, I was sick with the shoulder joint inflammation, unable to move my hand. I borrowed Biomag from my sister and used it twice a day in the basic application. In three weeks I was totally fine.
The wife had trouble with her right hip and left shoulder. The pain either disappeared or subsided.
Hello, I am interested in a free consultation and treatment of Biomag magnetic therapy devices for treating shoulder joint arthrosis (arthralgia). Please contact me.


text:
Year : 2017 | Volume : 20 | Issue : 9 | Page : 1053-1064
Retrospective morphometric analysis of the infraorbital foramen with cone beam computed tomography
S Dagistan1, Ö Miloǧlu1, O Altun2, EK Umar3
1 Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Ataturk University, Erzurum, Turkey
2 Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, İnönü University, Malatya, Turkey
3 Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Yildirim Beyazit University, Ankara, Turkey
Ö Miloǧlu
Department of Oral and Dentomaxillofacial Radiology, Faculty of Dentistry, Ataturk University, Erzurum
Objective: The aim of our study is to examine the morphometric characteristics of the infraorbital foramen (IOF) and its anatomic localization by using cone-beam computerized tomography (CBCT). Materials and Methods: In our study, the anatomic characteristics of the IOF were identified by studying retrospectively the CBCT images of one hundred twenty-five (125) patients. These characteristics were assessed statistically in terms of age, gender, and right-left side. Results: In our study, 42% of them had IOF in circular form and 58% in oval form. Of them 66.90% of those in oval form were in oblique direction, 28.30% of them were in vertical direction, and 4.80% of them were in horizontal direction. The mean vertical diameter of the IOF was found as 3.71 ± 0.61 mm and its mean horizontal diameter was found as 3.17 ± 0.56 mm. The mean distance of IOF to midline were measured as 25.10 ± 2.17 mm, distance to upper edge of the orbita was measured as 41.91 ± 2.77 mm, distance to infraorbital edge was measured as 5.63 ± 1.77 mm, distance to the lateral nasal wall was measured as 9.32 ± 2.68 mm, distance to spina nasalis anterior was measured as 17.97 ± 3.99 mm, thickness of the soft tissue on the foramen was measured as 11.52 ± 2.40 mm, and distance between the right and the left IOF was measured as 50.20 ± 3.90 mm. Accessory foramen was found in 56.60% ratio. Conclusion: This study reveals that CBCT may guide for local anesthesia applications and for other invasive procedures in order to prevent the damage of the neurovascular structures during maxillofacial surgery by identifying the distances of anatomic points such as IOF having surgically importance.
Dagistan S
Miloǧlu &
Altun O
Umar E K
infraorbital foramen


Built in 1915, the Ord Golf Club is a 9-hole municipal golf course that has seen many changes through the years. Originally sand greens, this 2379 yard par 33/36 city park course hosted the 1959 Men's and 1962 Ladies' Nebraska State Sand Greens Tournaments. The course was upgraded to grass in 1964. The course has retained many of the original features; large mature trees, elevation changes, with Dane Creek winding through and along five holes for a shot-makers course. The addition of a pond for irrigation gives the player water to negotiate on eight of nine holes.
This course offers the skilled player a true test of shot-making ability, along with the perfect distance for the senior or average golfer to test his or her skills in a beautiful park atmosphere. The Ord Golf Club is a perfect location for corporate, family, or group outings. The Ord Golf Club is owned by the City of Ord. While the course remains open year round, weather permitting the Clubhouse is open from March 1st through December 24th with exceptions made for private parties and meetings.


A thriving city bursting at the seams with art, architecture, history, politics, and technology, Berlin should be at the top of your "must visit" list. The good news? You'll find the vast majority of Berlin's hotels to be quite affordable, reasonably comfortable, and conveniently located to a variety of sites and attractions. But what if you're looking to splurge a little? You'll want to stay at the InterContinental Berlin on the city's west side.
Book a Deluxe Room, and enjoy the IC Berlin's sleek contemporary design and massive, cozy bed. Do your best to secure a room in the IC's west wing, and you'll have a lovely view of Berlin's zoo and the city's expanses to the west. It's such a nice respite from the buzz of the city that you may be tempted not to leave your room, but you'll certainly want to venture at least as far as the IC's Executive Club, located at top of the hotel's east wing.
Daily access for two to the club costs between €65 and €90, depending on your status with IHG, and given all that the club offers, the cost is well worth it. A full buffet breakfast, including fruit, yogurt, cereals, sausages, and eggs to order, is available in the mornings. In the early afternoon, breakfast is replaced with a variety of cold snacks, including sandwiches, smoked meats, salad, and soup. The evening spread introduces hot foods, and a small selection of fish, meat, or vegetarian entrées are available each night. A dessert bar, with seemingly endless cake and custard choices, and a full wine, liquor, and beer bar, are also available in the evenings.
Gluten-free options in the Executive Club are plentiful but require a few questions and a little creativity. For breakfast, you'll want to focus on the eggs, fruit, yogurt, and prepackaged muesli, available in multiple varieties during a recent visit. For lunch and dinner, you'll need to ask questions of the English-speaking staff. Is the soup made with flour? Does the fish incorporate bread crumbs? How is the beef prepared? Answers will vary based on the day's offerings. The smoked meats, raw vegetables with various spreads, cheese selections, and salad, however, are always safe and tasty options.
Once you've luxuriated in the IC's Executive Club and enjoyed the view from your room, be sure to step out and explore the neighborhood. Kurfürstendamm is one of Berlin's best and busiest shopping areas for anything from international chain clothing stores to upscale department stores. Don't miss the Kaufhaus des Westens (KaDeWe), its gorgeous window displays, or its multiple floors of German snacks and restaurants!
Where? The InterContinental Berlin is located in stylish Kurfürstendamm: Budapester Strasse 2, Berlin (+49-30-26020).