Jennifer Tinsley wasn't thrilled indie beauty retail was so far afield in Augusta, Ga. She opened the store Field to remedy that problem.
The 1,100-square-foot space is filled with products from 45 emerging brands, including Clove + Hallow, Black Girl Sunscreen, Aisling Organic, Shaffali, HollyBeth Organics, Sanctuary Beauty, Rouge & Rye, and Jules and Esther. To be considered for Field's selection, brands must be vegan, cruelty-free and owned by independent entrepreneurs.
Field carries products from 45 emerging brands, including Clove + Hallow, Black Girl Sunscreen, Aisling Organic, Shaffali, HollyBeth Organics, Sanctuary Beauty, Rouge & Rye, and Jules and Esther.
Tinsley's indie beauty experience proceeds the store, which has been operational less than a month and launches officially on Oct. 5. In 2015, she introduced an indie brand named Field Botanicals, now shortened to Field. Originally a side hustle while Tinsley stuck to her government job in regional planning and community development, she committed to Field full-time last year and retooled the brand to concentrate on three items: fragrance mist Smell My Bod, odor-busting foot spray Smell My Foot and natural deodorant Smell My Pits.
"We need to preserve the good bacteria on our skin. We don't need to be washing our hair every day and the oils off of our body. It's not necessarily healthy for us to wash every day, but we don't want to smell bad. No one wants to stink," says Tinsley. "You can use these products without having to worry about smelling bad, and they're fun. I'm not uptight by any means – I'm kind of goofy, and I drop F-bombs – and these products reflect that." She notes the plan is for 60% to 70% of Field's sales to come the direct-to-consumer channel, but she welcomes clean beauty boutiques and natural grocers for its distribution, too.
Tinsley's brand, of course, isn't her sole focus at the moment. Field's short retail history started in March with an Instagram post by Shannon Monsoon, a friend of Tinsley's who ran nutrition studio in the spot Field calls home today. The post relayed that Monsoon was moving to Washington, D.C. Tinsley immediately jumped at the chance to secure the retail unit Monsoon was leaving behind.
"I had coveted the space. It was perfect for what I wanted to do," says Tinsley. Dating back to 1928, the space was occupied by a shop selling Schwinn bikes until five years ago – a Schwinn hanging in Field's window harkens back to its heritage – and resembles an urban loft apartment with wood beams and exposed utilities.
To find brands for Field, Tinsley went to Indie Beauty Expo in Dallas and searched on the wholesale merchandise platform Faire. Early on, the store's sales are balanced between the skincare, makeup and bath categories. "The sales so far and customer feedback have exceeded my expectations. I'm pleased about the response from the community, where there's obviously been a need," says Tinsley. Her sales goal for Field is $8,000 to $10,000 monthly.
Tinsley is tapping social media to raise awareness about the store. She's not afraid to ask customers if she can share pictures of them on Instagram Stories to help news of Field spread virally in the local area. To draw people to the store, Field will also be hosting workshops weekly. Tinsley is particularly keen on meet-the-founder events and allows founders to participate in them over Skype or Zoom. For example, Shaffali founder Shaffali Miglani is scheduled to virtually lead an ayurvedic skincare workshop in November.
The brand Field has been revamped to focus on three products: odor-busting foot spray Smell My Foot, fragrance mist Smell My Bod and natural deodorant Smell My Pits.


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Ayodhya authority approves Ram temple plans, construction can start.
Ayodhya Ram Mandir plan gets approval by ADA without any objection ; Construction will begin soon.
Shivcharan Das | HENB | Ayodhya | Sept 2, 2020:: Finally, the Ram Janmabhoomi Mandir plan gets approval. The Ayodhya Development Authority (ADA) has approved the blueprint of the Ram Temple that is to be built in Ayodhya. The area of the layout is 2.74 lac square metre and the temple will cover an area of 12,879 sq. metre.
The Ayodhya Development Authority (ADA) on Wednesday approved two layouts for Ram Janmabhoomi in Ayodhya after fixing a fee of Rs 2.11 crore payable by the Ram temple trust, officials said. One layout is for the entire Ram Janmabhoomi campus (open area) and the other is for the proposed Ram temple (covered area).
The approval paves the way for the Shri Ram Janmabhoomi Teerth Kshetra Trust to start construction work of the temple. The trust had filed its request for approvals on Saturday.
The first layout pertains to an area of 2,74,110 sq metre (approximately 67.33 acre) of the entire Ram Janmabhoomi campus and the second layout is of 12,879 sq metre for the Ram temple, which will be the focal point of the campus.
Neeraj Shukla, vice-chairman of ADA, had to convene a board meeting to approve the layouts. The vice-chairman himself has the authority to approve layouts only up to 25 acres. For any construction above this 25-acre limit, the vice-chairman has to convene a board meeting.
"The estimated construction cost of the Ram temple (covered area) was calculated on the basis of the public work department's (PWD) schedule. It came to approximately Rs 15 crore. On this cost, the labour cess was fixed," said Shukla.
Divisional commissioner MP Agarwal, who is also chairman of ADA, presided over the board meeting.
The board also charged a labour cess of Rs 15.36 lakh. The trust will have to deposit the fee in ADA's Punjab National Bank account, Ayodhya.
"After depositing the fee, the trust will start construction work of the Ram temple," said Champat Rai, general secretary of the trust.
The original design for the Ram temple was prepared in 1998 by the renowned Sompura family (who also designed for Somnath Temple) but there have been several changes over the years. The Bhumi Pujan for the Ram temple was held on August 5, and PM Modi was also a part of the ceremony. The temple authorities will however follow the mandatory rules in regards to the construction of the temple. The temple authorities have already obtained all the required NOCs.
News Flow: HT & TNN.
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This entry was posted on September 3, 2020 by hinduexistence in Ayodhya Ram Janmabhoomi Temple Movement, Ayodhya Ram temple construction, Demand for Ram Temple at Ayodhya and tagged Ayodhya authority approves Ram temple plans, Ayodhya Development Authority (ADA), Ram Temple Construction will begin soon., Shri Ram Janmabhoomi Teerth Kshetra Trust.
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Lijiang Introduction
Lijiang Lijiang Introduction
Travel in Lijiang
Lijiang Travel Guide
Lijiang Attractions
Lijiang Food & Restaurants
Lijiang Weather & Climate
Lijiang Travel Tips
Lijiang Photo Gallery
Lijiang Maps
Private Yunnan Tours including Lijiang
Kunming Dali Lijiang Shangrila Tour
Yunnan Odyssey Tour
Yunnan Ethnic Exploration Tour
Wild Yunnan Tour
Hot China City Tours
Lhasa Tours
Lijiang Tours
Pingyao Tours
Jiuzhaigou Tours
China Themed Tours
China Eco & Ethnic Tours
China Honeymoon Tours
China Train Tours
China Hiking Tours
China Tea Tours
China Educational Student Tours
Lijiang, a prefecture-level city in Yunnan Province, is located on the southeastern edge of the Qinghai-Tibet Plateau, and the middle reaches of the Jinsha River. It is an important stop for the ancient "Southern Silk Road" and "Tea Horse Road". The center of Lijiang urban area is located at 100°25' east longitude and 26°86' north latitude, with a total area of 20,600 square kilometers. Lijiang includes 1 city and 4 counties. By the end of 2020, Lijiang has a registered population of 1,236,067.
Lijiang old town (including Dayan, Baisha and Shuhe) was registered on the UNESCO World Heritage List in December 4, 1997. Its historical architectures and complex, ancient water-supply system distinguish Lijiang old town from others. With a history of nearly 800 years, the Lijiang old town is also an exceptional ancient town set in a dramatic landscape which represents the harmonious fusion of different cultural traditions to produce an urban landscape of outstanding quality. In addition to the Han, there are around 22 ethnic minorities living here.
Lijiang Facts
Chinese Name:丽江
Location: Northwest Yunnan
Opening hours: all day
Average Altitude: 2400m.
Reachable by: Flight, train, bus.
Climate: Subtropical monsoon climate
Entry Ticket price: from RMB50 (since 2019)
Airport: Lijiang Sanyi International Airport
Lijiang History
According to the record, Lijiang was marked as Lijiang in year 1276. Lijiang got its name from the Jinsha River which was named Li Shui in the old time. One hundred thousand years ago, the sapiens "Lijiang people" of the late Paleolithic were already active in this place. The discovery of cave rock paintings in the Jinsha River Valley and the numerous stone tools, bronze, and ironware prove that Lijiang is one of the important areas for ancient human activities in southwest China.
Lijiang was used to be ruled by the Mu family, the native chieftains, during the Ming & Qing Dynasties. After lots of changes, Lijiang City replaced the former manage agents in 2002 and finally named Lijiang City, covering present area.
The Baisha Old Town was once the political, commercial and cultural center for the local Naxi people and other ethnic groups for 400 years from the year 658 AD to 1107AD, and then the ruler Mu family moved to the Lion Hill and built the present Danyan Ancient Town.
Top things to do in Lijiang
Lijiang Old Towns
There are many towns around Lijiang, and the most popular ones are Dayan Old Town, Shuhe Old Town and Baisha Old Town, which are listed on "World Cutural Heritage" together. When we talk about Lijiang Old Town, it usually refers to the Dayan Old Town of Lijiang.
Dayan Old town, a national-level historical and cultural city, was built in the late Song and early Yuan Dynasty (late 13th century AD). It is a very well-preserved ancient town built by Naxi people with unique cultural background. The core area of the ancient town covers an area of 3.8 square kilometers. Inside the Dayan Ancient Town, Sifang Street, Mufu Palace, Wufeng Tower, and the Waterwheel are highlighted spots.
The Shuhe Old Town, also known as Shuhe Ancient Town, was one of the earliest settlements of Naxi ancestor in the Lijiang area. Nestled at the foot of Jade Dragon Snow Mountain, 6 km northwest of Lijiang old town, Shuhe was once a staging post at ancient Tea & Horse Road. Shuhe town is just like a small-sized Lijiang with a similar layout, which boasts a Square Street (Sifangjie) and rivers flowing at downtown. Compared with Lijiang, the town is less touristy and polished with more original characters.
The Baisha Ancient Town is located about 10 kilometers north of Lijiang City, bordered by Yulong Snow Mountain in the north. It used to be the ancient capital of the Naxi nationality and the center of culture. As one of the important birthplaces of the Naxi culture, the Mu family chieftain of the Naxi people has accumulated experience in planning towns in Baisha before moving to Dayan Ancient Town. In the ancient town of Baisha, "Baisha Murals" is the must-see highlight. The painting of the "Baisha Mural" lasted for more than 300 years from the early Ming Dynasty to the early Qing Dynasty. There are 55 pieces of Baisha murals in the town, most of them were created in the Ming and Qing Dynasties. Now they are stored in Dabaoji Palace, Liuli Palace, Dading Pavilion and Dajue palace respectively. The murals at Dabaoji Palace are the largest one in Lijiang.
Jade Dragon Snow Mountain
Located 15 km north of Lijiang old town, Jade Dragon Snow Mountain (Yulong Snow Mountain) stretches 35 km from north to south with 960-square-kilometers of snow-capped area. It has the southernmost glacier in the Northern Hemisphere. Of all the 13 peaks on the mountain, Shanzidou is the highest with an altitude of 5,596 meters above sea level. As one of the first batch 5A-level national scenic spots officially approved by the National Tourism Administration, and a national-level glacier geological park, the Jade Dragon Snow Mountain attracts a huge amount of tourists from home and abroad every year. In the Jade Dragon Snow Mountain area, the highlights are the Glacier Park, Impression of Lijiang, Spruce Meadow, Yak Meadow, Blue Moon Valley and so on.
Tiger Leaping Gorge (Hu Tiao Xia)
98km south of Shangri-La, and 80 km north of Lijiang old town, Tiger Leaping Gorge is a canyon on the upper reach of the Yangtze River, which part is usually called Jinsha River (Golden Sand River). The gorge is located where the river passes between 5,596-meter-high Jade Dragon Snow Mountain and 5,396-meter-high Haba Snow Mountain in a series of rapids under lofty 2000-metee-deep cliffs. Legend says a tiger could jump across the river at the narrowest point (still 25 meters wide), hence the name.
Different HIKING ROUTES along Tiger Leaping Gorge are available for different needs. Get to know Tiger Leaping Gorge hiking route & itinerary, map, road conditions, elevation and detailed.
Lugu Lake
Lugu Lake is a gem located at the mountainous area on the border of Sichuan and Yunnan Province. About 240 km northeast of Lijiang, the lake occupies an area of 50 square kilometers with the average water depth of 45 meters. The lake is sparklingly clear, dotted with 5 islands, as the highest lake in Yunnan province with an altitude of 2,685m. Lugu Lake Scenic Area, with its typical plateau lake natural scenery and unique Mosuo matriarchal ethnic culture, has formed a distinctive natural landscape and humanistic landscape. Due to its beauty, Lugu Lake is regarded as the "Mother Lake" by the local Mosuo people, and "fairy land" by lots of outsiders.
How to get to Lijiang
There are two airports with Lijiang area, the Lijiang Sanyi International Airport and Ninglang Lugu Lake airport.
The Lijiang Sanyi Airport is located in Qihe Town, Gucheng District, Lijiang City, and is the second largest airport under the Yunnan Airport Group. Up to now, there are 34 airlines operating in Lima, 74 cities, and 7 international and regional routes. The downtown area of Lijiang is about 30 kilometers away from Lijiang Sanyi International Airport, and the journey takes about 50 minutes. The airport shuttle bus runs between Lijiang Sanyi airport and the Lantian Hotel, which is about 1km away from the exit of the Lijiang Ancient Town.
The Ninglang Lugu Lake airport was officially opened to air traffic on October 12, 2015. The altitude of 3293 meters makes it the highest airport in Yunnan Province. As of September 2018, Ninglang Lugu Lake Airport has connected with 4 cities by air, Kunming, Guiyang, Chengdu and Chongqing.
By Train or bullet train
Lijiang Railway Station is located in Lijiang City, Yunnan Province. Up to 2011, the construction area of Lijiang Station is 11891 square meters, the total area of the waiting room is 6971.61 square meters, and the scale of the station is 3 platforms and 7 train lines.
Public bus No. 16, 18, 104, 4 can help you reach the Lijiang Ancient Town from the Lijiang train station.
Lijiang Nightlife
Lijiang, located in the northwestern part of Yunnan Province, is one of the most famous tourist cities in China, and the Lijiang Ancient Town (Dayan Old Town) is a tourist attraction that many tourists are yearning for. In addition to being world-famous cultural heritage, Lijiang Ancient Town is also famous for its rich "nightlife". Most ancient towns become quiet at night, not like Lijiang. Lijiang Old Town becomes more vibrant at night. There are a lot of bars in the Lijiang Old Town, and the density of bars there is really amazing. These bars with closed doors or quiet atmosphere during the day will immediately become lively and busy at night.
Lijiang main Minority Ethnic Culture
Naxi (or Nashi or Nakhi)
The Naxi people mainly live in Lijiang, and they have their own language. Family organizations are widespread among the Naxi people, and they are a highly concentrated ethnic group. The father has great power in society and in the family. Major events such as marriage, funerals, and building construction all are decided by man. Only when the father is absent, the mother can assume part of the father's power.
The Naxi people generally live in plain, river valleys and mid-levels. Folk houses in the dam area are mostly tiled houses with civil structures, and the layout is mostly "three houses and one wall". The mountainous areas are mostly low wooden houses with wooden roofs. The Naxi people are good at singing and dancing, and they often perform mass singing and dancing activities in labor and ethnic festivals. The "Sanduo Festival" at the beginning of the second month of the lunar calendar is the most solemn traditional festival for the people of Naxi.
Mosuo
The Mosuo people live on the shores of Lugu Lake at the junction of Sichuan and Yunnan. They have a population of about 50,000. Mosuo people have their own national language but no written character. Strictly speaking, Mosuo is a branch of the Naxi ethnic group. Mosuo people are known for its matriarchal society and marriage custom. Here women and men usually do not get married, unless the family needs a female successor or male labor. Young women and men express their feelings to each other through singing and dancing. After they have an emotional foundation, they both agree to "walking marriage". Then the man can only sneak into the woman's room after nightfall, and leave before dawn. The children born in walking marriage are brought up by the woman's family, and the man does not take the responsibility of raising children, but the father and children admit their parent-child relationship. Family house and property is inherited by women.
Lijiang Cuisine
Traditional Naxi cuisine includes many kinds of snacks and dishes with local feature taste. Here below are some native dishes. No worry if you only like western style food. Many restaurants and cafes provide varieties of western food like pizza, hamburgers, sandwich, spaghetti and others.
1. Preserved Ribs Hot Pot: The main ingredient of the dish is pig's rib, which is preserved with salt and air dried for a long time. Air drying salted pig's rib brings a stronger flavor. It is usually served with fresh vegetables: mint, leek root, tomatoes, celery, yam, wild mushrooms, mushrooms, isatis root, vermicelli, etc. Cooking these ingredients together with a special sauce, nobody can stop the curiosity to try it.
2. Chicken pea jelly: Chicken pea jelly is a traditional food loved by the Naxi people. It is a kind of soybean. This kind of beans is milled to powder and then make different shape noodles, which is gray-green in color. With different seasoning, it comes up with different taste, but always makes people mouth watering. It is a popular dish on the table of the Naxi people.
3. Lijiang Baba: The main raw material is local wheat powder, mixed with such as ham, sugar, potato, sesame, etc. Usually there're two flavors available for travelers to try.
4. Rice & Blood sausage: Rice & Blood sausage is a kind of sausage made of pig blood, rice and various spices, mixed together according to a certain ratio, and then poured into pig intestines. Cook in a steamer, and then cut into slices. It taste really special and you may like it if you are ok with the ingredients.
5. Naxi Barbecue: "Naxi Barbecue" is a traditional horse caravan dish popular on the Lijiang Ancient Tea Horse Road. The main ingredient is streaky pork. Fat but not greasy, thin but not too dry, it has a crispy taste.
6. Eight Treasures Pineapple Rice: This is a traditional Lijiang specialty. It is glutinous rice, mixed with sugar, oil, osmanthus flowers, red dates, lotus seeds, longan, and other materials, and then steamed. Finally served in an empty pineapple. The taste is sweet, and it is a good treat for festivals and hospitality.
Recommended Lijiang Tours
Splendid Lijiang and Lugu Lake Tour
Lijiang Tour with Jade Dragon Snow Mountain
Lijiang Highlights Tour


Many men, women, and children still suffer from months-old and partially healed trauma injuries sustained over nine months of conflict creating a vital need for access to post-operative care, rehabilitation, secondary surgeries and other forms of follow-up care.
Ahmed gingerly moves his left foot, up and down slowly, while lying in a hospital bed in eastern Mosul. His face is gaunt and his speech laboured as he exchanges a few words with the medical staff who watch over him. A doctor needs encouragingly at the patient`s slow and steady progress.
Three weeks ago, even these small movements were almost impossible. Since arriving at MSF`s Al Taheel hospital, Ahmed has received a series of surgeries and post-operative care for injuries sustained over four months ago in an explosion outside of his home. Four of his neighbours were killed in the blast, but survivors carried him to a nearby hospital.
There, Ahmed received emergency surgery to stabilize his condition. But shortly after, the hospital was hit in an airstrike. Despite his precarious medical condition, Ahmed was able from flee the embattled hospital to a relative's house. But he could not make it to another medical facility for weeks due to the fighting that raged around him.
Throughout the battle, emergency responders, including MSF, have provided life-saving interventions for the freshly wounded wherever it was possible to reach them, and first-line surgery remains critical for those caught amid the ongoing conflict in western parts of the city.
But stories like Ahmed`s reveal another medical need unfolding far more silently, affecting many of the hundreds of thousands of people who are trying to get on with their lives in safer areas of eastern Mosul and in displaced persons camps.
In these places, many men, women, and children still suffer from months-old and partially healed trauma injuries. Civilians walk with shrapnel still embedded in their bodies, hampering their movements. Men, women, and children suffer from old burns and gunshot wounds.
Patients who received external fixtures to stabilize shattered bones now have metallic pins protruding from broken limbs, at risk of infection.
For them, the journey of healing from the incapacitation of war injuries toward anything resembling a normal life is still long and very uncertain. Most hospitals in Mosul have been damaged or destroyed, meaning patients struggle to access healthcare and provision of post-operative and rehabilitative care is desperately lacking.
MSF is operating two projects aimed at providing these vital services, but it can only help a very small proportion of those who require assistance.
Abood is a young boy receiving rehabilitative care at MSF`s project in Hamdaniya, 35 km outside Mosul. Having been hit in the back by a bullet while fleeing the fighting in Mosul, he understands all too well the life-changing difference that access to post-operative care can have. Initially, doctors warned that he may never walk again.
"I was completely paralyzed… there was no hope left in my case," he says. But after being referred for rehabilitative care with MSF, like Ahmed, Abood is now also making incremental progress, day by day. "There has been a lot of progress," he says.
For the countless others who cannot access the post-operative care they need, the future is less certain.
MSF is providing urgently needed medical assistance to residents of Mosul in eight project locations in and around the embattled city, including surgical interventions for war-wounded, maternal care, malnutrition, mental health and other medical services.
In Al Hamdaniya, MSF has provided 275 patients with post-operative care, rehabilitation and psychosocial support in collaboration with Handicap International. In Al Taheel, MSF has provided more than 175 surgeries, mainly for follow-up surgical interventions and trauma-related cold cases.
MSF offers neutral and impartial medical assistance regardless of race, religion, gender or political affiliation. In order to ensure its independence, MSF does not accept funding from any government or international agency for its programs in Iraq, relying solely on private donations from the general public around the world to carry out its work.
Find out more about MSF's activities in Iraq.


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Inflation in food articles basket was 6.99 per cent, down from 7.37 per cent in April
Press Trust of India | New Delhi June 14, 2019 Last Updated at 12:30 IST
WPI inflation data for March has been revised downwards to 3.10 per cent from provisional 3.18 per cent
Wholesale price-based inflation slipped to 22-month low at 2.45 per cent in May helped by falling prices of food articles, fuel and power items, according to an official data released Friday.
The Wholesale Price Index (WPI)-based inflation was at 3.07 per cent in April. It was 4.78 per cent in May 2018.
Inflation in food articles basket was 6.99 per cent, down from 7.37 per cent in April.
However, onion prices spiked during the month with inflation at 15.89 per cent, as against (-) 3.43 per cent in April.
Vegetables inflation eased to 33.15 per cent in May, down from 40.65 per cent in the previous month. Inflation in potato was (-) 23.36 per cent, against (-) 17.15 per cent in April.
WPI inflation in May is the lowest in 22 months, since July 2017, when it was at 1.88 per cent
Inflation in 'fuel and power' category cooled to 0.98 per cent, from 3.84 per cent last month. Manufactured items too saw decline in prices with inflation at 1.28 per cent in May, against 1.72 per cent in April.
WPI inflation data for March has been revised downwards to 3.10 per cent from provisional 3.18 per cent.
Data released earlier this week showed retail inflation spiked to a 7-month high of 3.05 per cent in May on costlier vegetables, and protein-rich items.
The Reserve Bank, which mainly factors in retail inflation for monetary policy decision, on June 6, lowered its benchmark lending rate to a nearly 9-year low of 5.75 per cent, even as it upped its inflation projection to 3-3.1 per cent for the first half of 2019-20.
Flagging uncertain monsoon, unseasonal spike in vegetable prices, crude oil prices, financial market volatility and fiscal scenario as risks to inflation, the RBI projected upward bias in food inflation in near term.


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Raptor Programming
The liver is a vital organ its strategic location and multidimensional functions support almost every organ in the body
The liver is a vital organ its strategic location and multidimensional functions support almost every organ in the body (Singh R et al., 2013, Swaroop T et al., 2012). It performs a fundamental role in regulation of diverse physiological process. Liver diseases are major health problems across the world (Delgado M.C et al., 2015). Liver disease is the term indicates damage to the cells, tissues, structure or impairment in liver functions. This damage can induce by biological factors, autoimmune diseases, and toxic chemicals as well with drugs or medicines (Deshwal N et al., 2011). Certain medicinal agents, when taken in overdoses and occasionally even when introduced within therapeutic ranges, may injure the organ (Ostapowicz et al., 2002). Hepatotoxicity is the key reason to withdrawn of drug form market. There are more than 900 drugs have been implicated for causing liver injury or liver toxicity (Aashish Pandit et al., 2011). Chemicals that cause liver injury are called hepatotoxins (Friedman et al., 2003). The world health organization determined that around 2.4 million deaths yearly are linked to liver disease and that around 800 thousand of deaths attributable to cirrhosis (Ian A et al., 2016). The damage or infection in liver categorized in a various types, depending upon the condition including acute fatty infiltration, cholestatic jaundice, liver granulomas, liver steatosis, active chronic hepatitis, liver cirrhosis, liver tumors etc (Ozer J et al., 2008). Injury and function of liver evaluated based upon clinical signs, a select group of serum clinical biomarkers, and occasionally liver biopsy (Yang X et al., 2012). The ideal attributes of a hepatotoxicity biomarker, including: organ specificity; a strong correlation with histopathology (Ozer J et al., 2008).
Over a few decades ago, the rate of intoxication of chemical materials has amazingly increased (Rahimzadeh R et al., 2010). People may use some drugs and chemicals in wrong way; as a result they may be poisoned intentionally or accidentally (Rahimzadeh R et al., 2014 and Paudyal B.P et al., 2005). Heavy metals are similar to other poisonous chemicals, from natural or industrial sources, can pose serious threats to human life (Rahimzadeh R et al., 2013). Cadmium poisoning has been reported from many parts of the world. It is one of the global health problems that affect many organs and in some serious cases it cause death (Mehrdad R.R et al., 2017). It is considered as deleterious pollutant that threats both animals and human health. Cd as identified as a category-I human carcinogen, due to its potential to induce pulmonary tumors (Waalkes M.P et al., 2003). The key sources of Cd intoxication cigarette smoking and ingestion of contaminated food or water (Skipper A et al., 2016).
Link to Qa: https://www.codeavail.com/The-liver-is-a-vital-organ-its-strategic-location-and-multidimensional-functions-support-almost-ever
1000 Answers Hire Me


I'm so excited to have found this site! This is my first design since Girlsense shut down all those years ago!
Re: First Design in Years!
I love it - how much for?
Thanks all! BBates - I'd be happy to sell it, but as I'm totally new to the site, I have absolutely no idea how much anything goes for :P I trust that you'll make a fair offer though, so feel free to offer whatever you think is reasonable.
Wow! What a beautiful dress! Love the color. Also, take a look at "the Catalogue" under the "Shop" tab on the side bar. That should give you an idea of prices and things like that!!
So beautiful and very happy to have you here!


Question of the day (23rd March).
Oh God that was such a weird week for me really. Don't know if I'll be writing anything about it, it's very complicated and I'm terribly ambivalent about the whole thing, but if I will, not now I guess, need to think about it. The definitely positive thing is that I got to finally finish my Welsh course for good, and now I'm doing very advanced stuff, or so it feels for me, my brain is all steaming and burning.
So let's get to our overdue questions of the day.
Are you named after anyone? If you had to choose, who would you be named after in your family?
takes away lots of charm from very elegant and sophisticated sounding Anna and makes it shallow, I definitely wouldn't like to be an Ania, and being an Anna in Poland I would inevitably be called Ania by almost everyone pretty much automatically. If my first name was Anna, I would like to be called just that, Anna, but that would be quite unusual here, where people like to nickname most names, especially if I was a kid, I doubt anyone would call me by my full name. 😀 But I'm digressing horribly hahaha. So yeah, I'm named after my Mum, and I'm OK with it. But if I had to choose another person from my family to be named after, I would go with my grandma – Helena. – I just love this name, and I'd like to be named after her. And I could keep my middle name happily. I could be also Anna Helena, but, as I said, as long as they'd call me Anna, or maybe even (a bit fancifully) with my both names, that would be cool, albeit a little snobbish I guess to always go by Anna Helena. 😀 Not quite normal here.
Posted on March 30, 2019 Categories Baby names, DiaryTags about me, family, get to know me, names, naming, q&a, qotd, question of the day, readers8 Comments on Question of the day (23rd March).
Despite having a tween-aged sister who watches unbelievable amounts of both kids and teen shows with catchy earworm tunes, I myself live under the rock and neither of these sound particularly familiar to me. 😀 Nevertheless, the names of the heroines are all very nice, yeah I must say I like all of them to some degree. My most favourite on this list is Luna, I love its cold and smooth sound, and I love the moon so how couldn't I like this lovely name. Personally I wouldn't use it, it seems to be more popular for pets than kids over here, and I've got a little fed up with hearing it over and over again from my sis who is a die hard fan of the "Soy Luna" series, but despite that, I still love this name. Oona has a lovely, Celtic feel, and Esme is very pretty, even though I dislike the fact that "Twilight" has made it so popular.
I like Delaney for a girl, and Flynn for both sexes, they are my most favourites out of these.
St. Patrick's Day is just around the corner so why not full name inspiration from some Irish surnames that are perfect in the first name spot! Everyone loves a great Irish name!
Brady has a very Varsity, pal-next-door, light-hearted, but grounded feel. An anglicized Gaelic name, Brady comes from Ó Brádaigh, meaning large-chested and currently ranks at Number 227 in popularity. Brady may remind you of the show "The Brady Bunch" or athlete Tom Brady.
Callaghan is such a lush, fun name to say that lends itself easily to the nickname "Cal." Callaghan is an anglicized form of Ó Ceallacháin which may mean bright-headed or church. The "g" is silent, pronounced "cal-a-han" and Callahan is a legit alternate spelling.
As for my opinions, well I guess I can't say for Americans and my view may be slightly different on these names.
I really really like Agnes. It has such an elegant, vintage charm to it, but if I didn't know already that many people think it's so very dated, I'd be really surprised to hear that, to me it sounds really girly and I just can't comprehend why anyone can think it sounds elderly. 😀 Maybe that's because our Polish Agnieszka, although maybe not the freshest of baby names these days, had been overwhelmingly popular since 70's all the way to 90's, and although not as favoured now, is still rather liked by people and doesn't feel dusted at all, and I'd be happy to see it coming back in the English-speaking countries, but maybe it's just too cute.
Dorothea probably is a bit too cute.
I definitely can't see Frances and Gertrude coming back, they do sound rather old to me, even though last year I read a book where the main character was named Gertrude and she was a young girl. I can't imagine it on a real life child in 21st century.
Ida is liked by namenerds and other quirky individuals in Poland, though we pronounce it EE-dah here, it's maybe not my style or anything that I would use, but I think it's perfectly usable overall and as opposed to Meagan's view, what I imagine first thinking about this name is a little, hyperactive and inquisitive girl.
I've become more convinced to Mildred in recent months or years, and grew to even like it a bit, but I guess too many people dislike it to make it successful again and it will stay among the geeky, quirky and evoking extreme emotions. Unless someone makes a bestseller with a protagonist named Mildred.
Opal could be indeed a nice alternative to Pearl.
And I actually love Selma! I primarily associate it with Selma Lagerlöf – Swedish writer – and I think it has both some youthful charm but also a lot of strength to it. Though with this -elma ending it probably won't be the next Emma.
Are these names too old or too cute? You be the judge!
Agnes is a polarizing name that you'll either feel is dusty and way-too-dated or darling and dainty. Agnes is a Greek name meaning virginal that does lend herself to the soft nickname "Aggie." Fans of the Bronte sisters may associate this name with the novel Agnes Grey as I do.
Believe it or not I'm seeing Dorothy pop up on lots of instagram and Youtube favorites list! The Greek Dorothea has a similar but different vibe and the wonderful meaning of gift of God. Perhaps the best part of Dorothea is the nickname potential she brings, a few of which include; Dori, Dot, Dottie, and Thea.


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Les germacrènes sont une classe d'hydrocarbures organiques volatils de formule brute . Plus précisément, ce sont des sesquiterpènes. Ils sont produits chez certaines espèces végétales pour leurs propriétés antimicrobiennes et insecticides, bien qu'ils jouent également un rôle d'imitations de phéromones d'insectes. Parmi les cinq isomères de germacrènes, deux sont plus importants : le germacrène A et le germacrène D.

Références

Hydrocarbure polycyclique non-aromatique
Sesquiterpène
Composé phytochimique volatil

redpajama_set_name: RedPajamaWikipedia


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The Chinese white-toothed shrew (Crocidura rapax) is a species of mammal in the family Soricidae.

Description

The Chinese white-toothed shrew is described as medium-sized with light brown dorsal fur and a faintly-colored dichromatic tail.  Compared to Crocidura attenuata, its posterior upper premolars are not severely concave, exposing less bone material.  The skull of Crocidura rapax is also longer than that of Crocidura indochinensis with a "proportionately broader maxillary to interorbital region but with a comparatively narrow braincase relative to skull length and maxillary breadth".

References

Crocidura
Mammals described in 1923


1st up MPB ,Anyone point me to any articles concerning this,is it a possible side?
Also I read part of a article on a post saying gyno was highly improbable ?
Is Nova alone good enough for PCT and should milk thistle be continued throughout PCT since nova is liver toxic?
Also assuming I'd need the 6oxo for PCT?
Can anyone give me a cheap link to buy if thats allowed here,assuming it is because its legal still [I think] but have'nt seen any direct links so thought it might be dodgy?
Read some of the guys journals and experiences,seems inconclusive.I've always read the post below&used the search function for the last hour,opinions are way more varied than those on say a dbol cycle.The jury seems out .
Any androgenic substance will speed up an already existing condition of MPB. Basically, if you have MPB/are prone to it (you may not even know yet depending on age and degree of MPB), any androgenic substance such as M1T will speed up that process.
In theory, however in practice gyno may occur through the progesterone route...perhaps, although one thing is for certain, there have been people who have run M1T and experienced gyno.
Nolva is good for PCT - run a 60/40/20 taper (Day1/2-11/12-21 or similar). Milk Thistle can be taken through PCT.
Not if you are using nolva - waste of money to use a weak substance like 6-oxo when already using nolva, and unnecessary.
Also, drink lots of water on cycle, M1T can be harsh on kidneys.
I only used nolva for my pct and i was fine mate.
Could anyone help me outline a basic quick course,used the search function but its varies considerably.
2weeks long enough? and at what dose,taper?
I'm assuming 180 is way more than enough for a small cycle?
Is there any chance of a dbol like water bloat?,also is the loss of appetite a common side,my appetites not great at the best of times?
do you like the 2 weeks on, 2 weeks off, 2 weeks on cycle?
Just gave advice as Trent seems to want to do it.
As for the 2 weeks on, 2 weeks off 2 weeks on, no I can't say I'm a fan of that tbh - too much flucuation and not enough time with PCT etc in between - IMO it will play havoc with your body.
i know some one who did that cycle TT, and he's still having problems trying to find his little friends after doing i think another nolva pct and having loads of trib..
Trent, for pct you might want to consider taking some trib at about 3g a day, i don't think its essential but alot of people add it in.
I have ran a few M1T cycles before. I used to do 10mg/day for 4 weeks but didn't get great gains from it. Next time I am going to try 20mg/day for 4 weeks to see how I get on. I wouldn't advise going above 30mg/day as it can give some bad sides. Try 10mg/day first and see how you get on. I ran milk thistle at 800mg/day and found no problems at running at that dose, but I would not recommend any dose lower than that. I did not get any gyno symptoms and to be honest you would be very unlikely to to get gyno, but i'm not saying it isn't possible. I ran PCT for 2 weeks with 6-OXO and it worked fine. But in future I will use clomid. I would say do between 2-4 weeks on cycle and have atleast your time on + pct = time off. I personally wait longer.
At first I wasn't convinced you would need PCT for M1T, but by my third week my balls had definatley shrunk, so I decided to run PCT to kick my balls back into action.
Great stuff guys,cheers thinking over my options.
Just to add one last thing LOL. I have since this post flushed all my M1T down the toilet at the advice of bbigman, as I am using dbol now anyway, and the two just don't even compare.
Tryed Dbol mate and I looked like a pregnant hippo plus I got gyno really quicky,actually guys can Nova be run all thru a M1T cycle since I know I'm prone and also is'nt it unfair to compare M1T to dbol since a dbol course is 6wks?
I G N O R E,sorted lads.
MCT or anyone could you check my post above the last one,pct related?
Personally, I wouldn't run nolva throughout, but you can I guess, if you are gyno prone - but you would be unlucky to get it with M1T...but remember, nolva is not a side-effect free drug.
Guys if I order my M1T + Milk T [got the nova] tonight on 48hr I can start tues for a 2week cycle but in 3weeks I have to go oup North for my girls birthday for 10days which means my diet will be affected+ I could only train at her gym a couple of times?
Obviously I have time for 1 full week of PCT and I can continue to take my nova+Milk T with her but am I looking at a big dent into my gains?
If so perhaps I should postpone? thoughts please?
Maybe start my cycle a week late and run a 3 week course thus taking the M1T with her?


The Jaguars (3-1) head to Arrowhead Stadium on Sunday to face Mahomes and the Chiefs' high-flying offense in what is arguably the game of the week.
The Jaguars (3-1) head to Arrowhead Stadium on Sunday to face Mahomes and the Chiefs' high-flying offense in what is arguably the game of the week. Jacksonville's only loss came by a field goal to the Titans, while the Chiefs (4-0) are coming off a dramatic fourth-quarter comeback win in Denver.


Synopsis: Disabled Sreekuttan and his buddy Bhavyan are a simpletons without many dreams. However, the duo will not tolerate insults and humiliation. After being disgraced by a newly-joined police officer in their village, they set out to take revenge.
Story: Mollywood has evolved over the years. It has given a break to the stereotypical hero who is a package of muscles and a baritone. After Vinayakan and Vishnu Unnikrishnan breaking that mould, comes Bibin George, a real-life polio victim. He plays the protagonist in Shafi's Oru Pazhaya Bomb Kadha and his character in the movie is no less than any other 'heroes'. He sings, dances, takes care of his family, romances and even does action sequences, all while proudly flaunting his polio affected left leg. The film inspires all those who love to find minute reasons to crib about life and find excuses for not achieving their potential.
On one occasion, Sreekuttan (Bibin George) tells Sruthy (Prayaga Martin) to whom he has a one-sided affection, "I have never felt that I am disabled, if you are feeling so, it is your mistake, not mine." The entire film revolves around Sreekuttan and as you watch the movie, you too would realise that ability and disability are relative concepts.
Sreekuttan and his best buddy Bhavyan (Hareesh Kanaran) are employees of a workshop in their village Muthamkode, a typical village in Kerala like the good old Peruvannapuram. The duo is popularly known as onnarayum onnarayum as one is disabled and the other begins his day by drinking one-and-a-half peg of alcohol. Sreekuttan's dad is sick and needs a heart surgery. He has worked hard for his earnings. There is the pretty Sruthy with whom Sreekuttan falls in love at their first encounter itself. He is hopeful that the girl would love him back. Things are moving smoothly when a new police officer Rajashekharan (Shajon) takes charge in the village. A vicious person, on his first day in the village itself, he gets involved in an ego clash with Sreekuttan and waits for a chance to trap him. As the film progresses, the police officer gets a chance to take out all his anger on Sreekuttan. How the disabled Sreekuttan takes revenge against the policeman for the losses he has caused him is the thread of the story.
The maker of Kalyanaraman, Pulivalkalyanam and Marykkundoru Kunjadu join hands for the entertainer which has all the elements that a Malayali movie goer would enjoy. The uniqueness of this film is that there is no misogyny which pop up occasionally in Shafi's films in the form of slapstick comedy and the lead character- a man who never blames anyone for his disability but lives life to the fullest like anybody else.
The film is a gift to Bibin George, the scribe turned actor who has showcased a fabulous performance. The actor can make a viewer feel guilty about considering someone with a disability as less fortunate, by doing all that we imagine he cannot, including the stunt sequence in the climax.
Prayaga, though, is just eye candy in the film. Shajon takes over in some sequences as usual and Hareesh Kanaran is the master of the show.
Arun Raj's music and Bijibal's background score enhance the entertainment factors of the film. The writers Binu Joseph and Sunil Karma need appreciation for their out of the box characterisation of the hero and also for developing a novel thought into a film. Though Mollywood had films like Keli and Kunjikoonan, which had disabled heroes, it is the first time, a disabled person plays the lead hero.
However, some of the jokes in the film fail to elicit a laugh. But Shafi has to be applauded for triggering nostalgia in viewers by weaving the music and dialogues of old Malayalam movies like in his previous film, Two Countries.
Oru Pazhaya Bomb Kadha is a proper entertainer with a message for all those who think they are 'underprivileged'. It makes us question our definitions of normal and abnormal and ability and disability.


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Bell Expands 5G Network in Manitoba, Ontario and Quebec
Bell announced on Tuesday its 5G wireless network has expanded in Manitoba, Ontario and Quebec to 23 new cities and towns, seen below:
Manitoba (St. Andrews and Stonewall)
Ontario (Barrie, Burlington, Clarington, Guelph, Hamilton, Kingston, Kitchener, London, McNab/Braeside, Moravian, Pickering and Waterloo)
Québec (Ascot Corner, Champlain, Magog, Rivière-du-Loup, Saint-Catherine-de Hatley, Saint-Luc-de-Vincennes, Saint-Maurice, Sherbrooke and Trois-Rivières)
"As we continue to expand into new cities and towns, more Canadians will benefit from access to the superfast speeds, low latency and next-generation applications enabled by Canada's most-awarded 5G network, supported by the latest 5G devices and newest unlimited data plans," said Claire Gillies, President of Bell Mobility, in an issued statement. "Leading the way in 5G is a key part of Bell's goal to advance how Canadians connect with each other and the world."
Bell says its 5G network can hit theoretical download speeds of 1.7 Gbps and coverage is available for 35% of the Canadian population, with plans to double its reach by the end of 2021.
Other articles in the category: Bell
Staples to Exclusively Sell Bell Services, Rogers and Telus Dropped
Staples Canada and Bell announced a multi-year exclusive agreement on Tuesday, to sell Bell, Virgin Plus and Lucky Mobile wireless and wireline services at Staples stores across Canada for both consumers and small businesses. Both companies will also partner to sell Bell services to medium businesses through the Staples Professional sales team. Beginning in late […]
What's New on Crave: February 2023
We're rounding the corner into another month and Bell Media today has shared its list of what's new on the Crave streaming service for February 2023. February is Black History Month and Crave has highlights featuring Black creators, talent, and cultural figures with various curated special collections. One upcoming title is the TSN and Crave Original […]
iPhoneinCanada.ca
Bell Aliant Charges Senior Hundreds for Local Calls in 'Programming Error'
Bell Aliant sent an invoice of almost $650 to one senior in Hammonds Plains, Nova Scotia, for two months of telephone service after overcharging him due to a "programming error" that billed his local calls as long-distance — reports the CBC. "Thirty-five dollars a month for the house phone, that's what they said I have...


Founded in 1883 by teachers and scholars, the Modern Language Association (MLA) promotes the study and teaching of language and literature which test are you preparing for? click for comprehensive study guides and strategies for performing your best on test day all for free! sat free essays, research papers, term papers, and other writings on literature, science, history, politics, and more.
Essay Topics for Kids That Help Sharpen Their Writing Skills below are all other entries received for the children's essay contest.


It's official: Spring is here, which means it's time to give yourself a big pat on the back for making it through another cold winter. With the new season upon us, it's finally time to tackle the often challenging seasonal wardrobe switch and say goodbye to your wool knits, fur-lined boots, and cloud-like puffer jackets for the next seven-plus months. But there are a few cold-weather staples to keep on hand to help piece together easy, chic, weatherproof winter-to-spring outfits.
Although your heavy wool coat is no longer needed, it's wise to keep your go-to leather trench on hand. It's the perfect alternative to thick outerwear because even though it's spring, the mornings can be quite chilly. Some other all-season must-haves to keep in your closet for now? A classic jumpsuit that can be made spring-ready in seconds, and a lightweight mohair sweater you can throw on over your go-to slip dress. Ahead, see some of the best transitional winter-to-spring outfits of all time, and shop the pieces needed to re-create each look in seconds.
A leather trench is the transitional piece you need ASAP.
A leather miniskirt is ideal for those chilly spring mornings. Add in tights when it's too cold, or go bare-legged when it's warm.
Work your go-to jumpsuit in your spring looks with a few easy layering tricks.
A black turtleneck, light-wash jeans, and a trench coat (perfect for rainy days) is one winter-to-spring outfit that will never fail you.
For an easy winter-to-spring outfit, layer your mohair sweater over your favorite slip dress. When it's too warm, simply remove the sweater.
A printed bodysuit is another layering staple that pulls all your winter-to-spring outfits together.
Yes, a suit is a transitional season must-have because it boasts countless styling possibilities.
Try pairing your favorite shorts with a cable-knit sweater this season.
Next up, see the fashionable spring outfits that will blow up this season.


Why Might You Need Help With Supplier and RFQ Management?
Across all manufacturing industries, the value generated in a company's supply chain continues to be more critical to its success. Outsourcing of design and manufacturing demands a product development platform that can handle the complexity of a globally dispersed resource subject to global regulations. With standard and engineered products representing a growing percentage of a company's direct costs, partnering with value-chain suppliers early in the development of a new product rings enormous benefits.
3DEXPERIENCE for Supplier and Sourcing Management is delivers and end-to-end solution for managing a sourcing ecosystem from RFQ to Supplier Score Cards. Engineering and quality managers can provide key suppliers with real-time access to appropriate project information, integrating them into concept design, quality management and their supplier execution process. Suppliers will be allocated responsibilities related to specific parts, enabling multiple suppliers to work concurrently across a common assembly with appropriate access. Part Quality Plans are assigned, allowing suppliers to adhere to the company's standardised improvement and planning best practices.
It includes cross-functional component management, enabling all stakeholders to work from a single component management system; allowing designers can identify components for sourcing while procurement gets improved visibility into engineering requirements to assist in make good sourcing decisions.
To find out more information about how Design Rule can help you with supplier and RFQ management, contact us online.


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Navy to name aircraft carrier for Pearl Harbor hero Miller
HONOLULU (AP) — The U.S. Navy is expected to honor a World War II hero when a new aircraft carrier is named for Mess Attendant 2nd Class Doris Miller.
The announcement is expected to be made at Pearl Harbor Monday, The Honolulu Star-Advertiser reported Friday.
Miller was the first African American to receive the Navy Cross for valor.
Miller was recognized for manning a machine gun on the USS West Virginia and returning fire against Japanese planes during the Dec. 7, 1941 attack on Pearl Harbor.
USS Miller, a destroyer escort, was previously named in his honor.
"I think that Doris Miller is an American hero simply because of what he represents as a young man going beyond the call of what's expected," said Doreen Ravenscroft, a team leader for the Doris Miller Memorial.
An African American was not allowed to man a gun in the Navy in 1941, Ravenscroft said.
"Without him really knowing, he actually was a part of the Civil Rights movement because he changed the thinking in the Navy," Ravenscroft said.
Two of Miller's nieces are expected to be at Pearl Harbor for the announcement on Martin Luther King Jr. Day.
Miller, then 22, was collecting laundry when the attack alarm sounded. His normal battle station in an antiaircraft battery magazine was destroyed by a torpedo. He went on deck and carried wounded soldiers to safety before receiving orders to aid the mortally wounded captain on the bridge.
"He subsequently manned a 50-cal. Browning anti-aircraft machine gun until he ran out of ammunition and was ordered to abandon ship," the Navy said, noting Miller was not trained to operate the gun.
Admiral Chester W. Nimitz, the commander in chief of the Pacific Fleet, presented the Navy Cross to Miller in Pearl Harbor in May 1942.
Miller died while serving on a ship that was torpedoed by a Japanese submarine in November 1943.
Southeast Health begins distributing COVID-19 vaccine to seniors


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The Village Beacon Record
The Port Times Record
The Village Times Herald
The Times of Middle Country
The Times of Smithtown
The Times of Huntington-Northport
Between You and Me
Medical Compass
The Culper Spy Adventure
The Abridged Works of Charles Dickens
Publishing LLC Notices
Home Arts & Entertainment SBU's Gopalan explores DNA clues and age for criminal cases
SBU's Gopalan explores DNA clues and age for criminal cases
Village Times Herald
by Daniel Dunaief - December 4, 2016
Above, Shyamalika Gopalan. The image on the screen shows methylation levels with age. Photo by Casey Youngflesh
By Daniel Dunaief
The Museum of Natural History in New York City features a slice of a 1,400-year-old sequoia tree that was cut down in California in 1891. The cross section of the tree offers a testament to history on its inside. That's where the tree rings that grow every year mark the passing of another year. As it turns out, humans have something in common with trees. While people may not have rings in bones that an observer can see, they do have age-related changes in their genetic material, or DNA.
Human genes go through a process called methylation in which a methyl group comprised of a carbon and three hydrogens attaches to DNA. Methylation upstream of a gene generally reduces transcription, or the copying of that gene into messenger RNA that can then begin the process of building proteins.
Shyamalika Gopalan demonstrates how she prepares to extract DNA. Photo by Casey Youngflesh
Using broad time-based methylation changes, Shyamalika Gopalan, who is earning her doctorate at Stony Brook University in the Department of Ecology and Evolution, recently received a three-year grant from the Department of Justice to refine an understanding of methylation and aging. The DOJ would like to use this kind of analysis to gather more information from a scene at which the remaining clues include DNA that isn't in one of its databases.
Gopalan isn't the first scientist to study genetic methylation and aging. Other scientists have used blood, saliva and other tissues. She is starting with one type of tissue in the bone. "I'm trying to make" the analysis "more specific to bones," she said. She doesn't know how much variation she will find in the age-related methylation patterns depending on ethnicity and lifestyle. "It does appear that some sites are remarkably 'clock-like,'" she said. "It is these types of sites I'm hoping to find and use in my research."
Gopalan explained that millions of sites can be methylated. She's hoping to hone in on those that act more like a clock and that change in a linear manner with time. She's not sure how many sites she'll use and said some changes in methylation involve removing methyl groups. "Some methylation increases and some decreases," she said. "If you know the pattern with age at any site, you can start to build an estimate from those."
Methylation occurs with age for several possible reasons. "A major theory for these changes in methylation level with age is that the epigenetic patterns are drifting from the optimum," she said. "This may explain some, or even most, of the changes we observe, but I don't think it is universally true for all sites in the genome." Still, there probably is a biologically relevant reason why some of these sites are changing, she suggested.
Gopalan said we know that these methylation patterns are crucial in early development, from conception to birth and she suggested it probably doesn't completely stop changing there. Some sites are probably regulated throughout life.
Gopalan is hoping to have the bone data prepared by this summer and then believes she'll be able to get methylation types and start working on a computer algorithm to build a predictor for the next year. After her initial work, she will also shift to saliva and blood.
Like a scene from "Law & Order" or other crime shows, the DNA methylation test may be another clue for police officers or prosecutors to use to rule in or out potential suspects from a crime scene where DNA, but not a driver's license, is left behind. If the genetic material is not in a database, "you could build a profile and it could be useful for narrowing down suspects," Gopalan said. At this point, she is taking data for people of age classes but with different ethnicities and lifestyles and comparing them to people of a different age with a similar range of backgrounds and lifestyles.
Gopalan is using samples from medical schools around the New York area, borrowing from anatomy departments where people have donated their bodies to research or teaching. More broadly, she is interested in studying diverse populations, especially in Africa. She has worked with her thesis advisor Brenna Henn, exploring methylation from two different populations. These are the ‡Khomani San of South Africa and the Baka of Cameroon.
Gopalan was interested in working with methylation as a biomarker for aging when she came across this funding opportunity from the DOJ. "It was a good fit for what I had already been studying," she said, adding that she hopes this method will be used in the future in forensics to assist in criminal investigations.
Krishna Veeramah, an assistant professor of primate genomics at Stony Brook and the chair of her thesis committee, described Gopalan as an "intellectually engaged student who is always eager to absorb information." Veeramah explained in an email that he thinks "there is scope for this work to transition from basic research" to an application "in criminal forensics and related areas. It will certainly require more work and testing."
Gopalan has been at SBU for over three years. She lives in Crown Heights, Brooklyn, and commutes about 90 minutes each way most days. She enjoys the beaches, farms, apple picking and the natural beauty of the area. Gopalan would like to continue to perform research after she earns her doctorate, whether that's with a company, a research institution or with a university. She is excited about extracting and working with DNA, particularly from archeological sites. These samples "come from a field and, once you dust them off, it makes it personal. This is a part of a story."
Brook University
Daniel Dunaief
Krishna Veeramah
Shyamalika Gopalan
The most effective treatment for strokes: prevention
Electric Holiday Parade returns to Three Village
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We provide you with the latest breaking news and information for your community.
Port Jefferson Library hosts online photography exhibit, Flower of Honor
Atelier at Flowerfield offers online lecture with Christian White
Suffolk County Sheriff's Office welcomes two canines to department


District 2 Councilwoman Ivy R. Taylor will host a District 2 redistricting meeting from 6:30-7 p.m. Tuesday at the District 2 Senior Center, 1751 S. W.W. White Road.
Due to the recent population growth in San Antonio over the last decade, the city must undergo redistricting, she noted.
Redistricting is a process that determines the boundaries of congressional and legislative districts based on population data from the U.S Census.
Redistricting usually occurs when the population in a district becomes uneven and through redistricting, each district is able to include an equivalent number of people.
Residents will be able to view proposed council district maps, provide input and suggestions and share concerns about the proposal.
For more information, call 207-0950 or 207-0970.


NEW YORK (Reuters) - Michael Moore, the left-wing filmmaker known for provocative documentaries that deliver a biting message, will release an anti-Donald Trump movie on Tuesday as Hollywood ramps up efforts to support Democratic White House contender Hillary Clinton in the final weeks of the 2016 election campaign.
Moore, the Oscar-winning maker of documentaries about guns, the Iraq war and the U.S. health system, said on Twitter he would release "Michael Moore in Trumpland" in a free screening in Manhattan on Tuesday night at one movie theater, followed by commercial release in theaters in Los Angeles and New York on Wednesday.
The film's release comes three weeks before the Nov. 8 election.
The film is based on a one-man show, "October Surprise," that Moore, a vocal critic of the Republican presidential contender, recently performed in Ohio and shows Moore "dive right into hostile territory," according to a brief description.
The film is being released as scores of celebrities rally round Clinton ahead of the Nov. 8 election. More than 30, including Barbra Streisand, Billy Crystal, Julia Roberts, Helen Mirren and Lena Dunham, staged a fundraising show on Broadway on Monday with tickets that sold for up $10,000 each and which was streamed live online.
Singer Jennifer Lopez and rocker Jon Bon Jovi will play separate Get Out The Vote gigs in Florida next week on behalf of Clinton's campaign.
"Iron Man" star Robert Downey Jr. and actors Neil Patrick Harris, Don Cheadle and Julianne Moore are among those asking Americans to "save the day" in a social media campaign aimed at getting people to vote against Republican businessman and former reality star Trump.
Clinton counts more, and more vocal, celebrity supporters than Trump, whose backers include Clint Eastwood, Jon Voight, country singer Loretta Lynn, Kirstie Alley and rapper Azealia Banks.
But fans of celebrities are not necessarily fans of the candidate they support. Comedian Amy Schumer was booed at her stand-up show in Florida on Sunday after she attacked Trump and Republican voters, causing some 200 audience members to walk out, according to the Tampa Bay Times.


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Travel Experiences from the Experts
UNIQUE ATTRACTIONS
Underground Rock Salt Cathedral
Museum of the Occupation of Latvia
St. Ives Museum
The Journey of Don Quixote
New Mexico Museum
Tsodilo Hills Botswana
Trip along the Pacific Coast Highway
Follow in the footsteps of Don Quixiote
from the Don Quijote website
"Take the Don Quixote routes in Castilla-La Mancha, Spain for a magical and educational holiday experience."
"In Miguel de Cervantes' infamous novel: The Ingenious Hidalgo Don Quixote of La Mancha, the principal character makes three adventurous trips through the Spanish regions of La Mancha, Aragon and Barcelona.
"Discover Spain as Don Quixote did with the officially recognized touristic Don Quixote route that passes through 148 Spanish towns throughout its more than 1,243 mi. of roads that cover a vast stretch of historical and livestock trails which are clearly indicated with signs. The route is divided into 10 itineraries and 56 stages that unite the most important sites highlighted in Cervantes' masterpiece. The Don Quixote Route was distinguished in 2007 as a European Cultural Route by the Council of Europe.
"The adventures of Don Quixote have spread throughout the world as one of the most translated novels in history. In Castilla La-Mancha, Spain, Don Quixote is a recognized cultural symbol. His legend has generated cultural tourism of people eager to experience the social and geographic reality of what Cervantes' masterfully described in Don Quixote of La Mancha. Visit Spain through the historical Don Quixote route."
Places | Attractions | Events & Cuisine | At Sea


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        ()

Clear all translation assets from :meth:frappe.cache

		frappe.translate.deduplicate_messages
        (messages)

No docs

		frappe.translate.extract_messages_from_code
        (code, is_py=False)

Extracts translatable srings from a code file

Parameters:

code -  code from which translatable files are to be extracted

is_py -  include messages in triple quotes e.g. _('''message''')

		frappe.translate.get_all_languages
        ()

Returns all language codes ar, ch etc

		frappe.translate.get_all_messages_from_js_files
        (app_name=None)

Extracts all translatable strings from app .js files

		frappe.translate.get_bench_dir
        ()

No docs

		frappe.translate.get_dict
        (fortype, name=None)

Returns translation dict for a type of object.

Parameters:

fortype -  must be one of doctype, page, report, include, jsfile, boot

name -  name of the document for which assets are to be returned.

		frappe.translate.get_dict_from_hooks
        (fortype, name)

No docs

		frappe.translate.get_full_dict
        (lang)

Load and return the entire translations dictionary for a language from :meth:frape.cache

Parameters:

lang -  Language Code, e.g. hi

		frappe.translate.get_lang_dict
        ()

Returns all languages in dict format, full name is the key e.g. {"english":"en"}

		frappe.translate.get_lang_info
        ()

Returns a listified version of apps/languages.txt

		frappe.translate.get_lang_js
        (fortype, name)

Returns code snippet to be appended at the end of a JS script.

Parameters:

fortype -  Type of object, e.g. DocType

name -  Document name

		frappe.translate.get_language_from_code
        (lang)

No docs

		frappe.translate.get_messages_for_app
        (app)

Returns all messages (list) for a specified app

		frappe.translate.get_messages_from_doctype
        (name)

Extract all translatable messages for a doctype. Includes labels, Python code,
Javascript code, html templates

		frappe.translate.get_messages_from_file
        (path)

Returns a list of transatable strings from a code file

Parameters:

path -  path of the code file

		frappe.translate.get_messages_from_include_files
        (app_name=None)

Returns messages from js files included at time of boot like desk.min.js for desk and web

		frappe.translate.get_messages_from_page
        (name)

Returns all translatable strings from a :class:frappe.core.doctype.Page

		frappe.translate.get_messages_from_report
        (name)

Returns all translatable strings from a :class:frappe.core.doctype.Report

		frappe.translate.get_server_messages
        (app)

Extracts all translatable strings (tagged with :func:frappe._) from Python modules inside an app

		frappe.translate.get_untranslated
        (lang, untranslated_file, get_all=False)

Returns all untranslated strings for a language and writes in a file

Parameters:

lang -  Language code.

untranslated_file -  Output file path.

get_all -  Return all strings, translated or not.

		frappe.translate.get_user_lang
        (user=None)

Set frappe.local.lang from user preferences on session beginning or resumption

		frappe.translate.guess_language
        (lang_list=None)

Set frappe.local.lang from HTTP headers at beginning of request

		frappe.translate.is_translatable
        (m)

No docs

		frappe.translate.load_lang
        (lang, apps=None)

Combine all translations from .csv files in all apps

		frappe.translate.make_dict_from_messages
        (messages, full_dict=None)

Returns translated messages as a dict in Language specified in frappe.local.lang

Parameters:

messages -  List of untranslated messages

		frappe.translate.pos_to_line_no
        (messages, code)

No docs

		frappe.translate.read_csv_file
        (path)

Read CSV file and return as list of list

Parameters:

path -  File path

		frappe.translate.rebuild_all_translation_files
        ()

Rebuild all translation files: [app]/translations/[lang].csv.

		frappe.translate.rename_language
        (old_name, new_name)

No docs

		frappe.translate.send_translations
        (translation_dict)

Append translated dict in frappe.local.response

		frappe.translate.set_default_language
        (language)

Set Global default language

		frappe.translate.update_translations
        (lang, untranslated_file, translated_file)

Update translations from a source and target file for a given language.

Parameters:

lang -  Language code (e.g. en).

untranslated_file -  File path with the messages in English.

translated_file -  File path with messages in language to be updated.

		frappe.translate.write_csv_file
        (path, app_messages, lang_dict)

Write translation CSV file.

Parameters:

path -  File path, usually [app]/translations.

app_messages -  Translatable strings for this app.

lang_dict -  Full translated dict.

		frappe.translate.write_translations_file
        (app, lang, full_dict=None, app_messages=None)

Write a translation file for a given language.

Parameters:

app -  app for which translations are to be written.

lang -  Language code.

full_dict -  Full translated langauge dict (optional).

app_messages -  Source strings (optional).

redpajama_set_name: RedPajamaGithub


text:
STRUCTURED COMPUTER ORGANIZATION TANENBAUM PDF
Friday, November 29, 2019 adminComment(0)
Library of Congress Cataloging-in-Publication Data. Tanenbaum, Andrew S. Structured computer organization. / Andrew S. Tanenbaum. —5th edition p. cm. Library of Congress Cataloging-in-Publication Data Tanenbaum, Andrew S., Structured computer organization / Andrew S. Tanenbaum, Todd Austin. -- 6th ed. p. Andrew S. Tanenbaum. With contributions from James R. Goodman. Structured Computer Organization is the fourth edition of this best-selling introduction to.
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BCIT-CST-/Structured Computer Organization by ANDREW S. TANENBAUM & TODD AUSTIN 6th Edition [bestthing.info].pdf. Find file Copy path. Fetching. ANDREW S. TANENBAUM. Vrije Universiteit STRUCTURED COMPUTER ORGANIZATION 2 MILESTONES IN COMPUTER ARCHITECTURE 苑井慨 焙 荼补 菘 幢狗补蠓搀蝎敬方楷繁 芸 . Tanenbaum, Andrew S.,. Structured computer organization / Andrew S. Tanenbaum, Todd Austin. 11 6th ed.
An accumulator machine has a combined left operand and result in an implicit accumulator for most arithmetic instructions. Other architectures such as and the xfamily have accumulator versions of common instructions, with the accumulator regarded as one of the general registers by longer instructions.
A stack machine has most or all of its operands on an implicit stack. Special purpose instructions also often lack explicit operands CPUID in the x86 architecture writes values into four implicit destination registers, for instance.
This distinction between explicit and implicit operands is important in code generators, especially in the register allocation and live range tracking parts. A good code optimizer can track implicit as well as explicit operands which may allow more frequent constant propagation , constant folding of registers a register assigned the result of a constant expression freed up by replacing it by that constant and other code enhancements.
Programs[ edit ] A computer program is a list of instructions that can be executed by a central processing unit.
A program's execution is done in order for the CPU that is executing it to solve a specific problem and thus accomplish a specific result. While simple processors are able to execute instructions one after another, superscalar processors are capable of executing a variety of different instructions at once.
Program flow may be influenced by special 'jump' instructions that transfer execution to an instruction other than the numerically following one. Conditional jumps are taken execution continues at another address or not execution continues at the next instruction depending on some condition. Main article: Assembly language A much more readable rendition of machine language, called assembly language , uses mnemonic codes to refer to machine code instructions, rather than using the instructions' numeric values directly.
Structured Computer Organization.
Structured Computer Organization, 6th Edition
Read more. Structured computer organization. Structured Computer Organization, 5th Edition. Structured Computer Organisation. Computer Organization 5th Edition.
Computer Organization and Design. Computer Organization Design and Architecture. Digital Design and Computer Organization.
If You're an Educator
Fundamentals of Computer Organization and Design. Computer Organization and Arquitecture 9th edition.
READ ALSO: GENOCIDAL ORGAN BOOK
Computer organization and architecture: Finally, there is a chapter on the increasingly important topic of parallel computer architectures. New to this edition: With nearly end-of-chapter exercises. The first three editions of this book were based on the idea that a computer can be regarded as a hierarchy of levels, each one performing some well- defined function.
This fundamental concept is as valid today as it was when the first edition came out, so it has been retained as the basis for the fourth edition. As in the first three editions, the digital logic level, the microarchitecture level, the instruction set architecture level, the operating system machine level, and the assembly language level are all discussed in detail although we have changed some of the names to reflect modern practice.
Although the basic structure has been maintained, this fourth edition contains many changes, both small and large, that bring it up to date in the rapidly changing computer industry. For example, all the code examples, which were in Pascal, have been rewritten in Java, reflecting the popularity of Java in the computer world.
Also, the example machines used have been brought up to date. Multiprocessors and parallel computers have also come in widespread use since the third edition, so the material on parallel architectures has been completely redone and greatly expanded, now covering a wide range of topics, from multiprocessors to COWs.
The book has become longer over the years although still not as long as some other popular books on the subject. Such an expansion is inevitable as a subject develops and there is more known about it.
As a result, when the book is used for a course, it may not always be possible to finish the book in a single course e.
A possible approach would be to do all of Chaps. The remaining time could be filled with the rest of Chap.
A chapter-by-chapter rundown of the major changes since the third edition follows. Chapter 1 still contains an historical overview of computer architecture, pointing out how we got where we are now and what the milestones were along the way.
The three new examples are described here at the chip level. Chapter 4 now called the microarchitecture level has been completely rewritten.
The idea of using a detailed example of a microprogrammed machine to illustrate the ideas of data path control has been retained, but the example machine is now a subset of the Java Virtual Machine.
The underlying microarchitecture has been correspondingly changed. Several iterations of the design are given, showing what trade-offs are possible in terms of cost and performance.
Also read: BLAME MY BRAIN NICOLA MORGAN EPUB
The last example, the Mic-4, uses a seven-stage pipeline and provides an easy introduction to how important modern computers, such as the Pentium II, work. A new section on improving performance has been added, focusing on the most recent techniques such as caching, branch prediction, superscalar out-of-order execution, speculative execution, and predication.The new example machines are discussed at the microarchitecture level.
These research projects have led to five books and over 85 referred papers in journals and conference proceedings. It presents hardware design principles and shows how hardware design is influenced by the requirements of software.
As in the first three editions, the digital logic level, the microarchitecture level, the instruction set architecture level, the operating system machine level, and the assembly language level are all discussed in detail although we have changed some of the names to reflect modern practice. Relationship to bytecode[ edit ] Machine code is generally different from bytecode also known as p-code , which is either executed by an interpreter or itself compiled into machine code for faster direct execution.
Pugsley, Ronald N. In multitasking systems this comprises the program's code segment and usually shared libraries. A stack machine has most or all of its operands on an implicit stack. I also want to thank Barbara and Marvin for being great kids and Bram for always being quiet when I was trying to write.
Related Post: MATHEMATICAL ELEMENTS FOR COMPUTER GRAPHICS DAVID F ROGERS PDF
Special purpose instructions also often lack explicit operands CPUID in the x86 architecture writes values into four implicit destination registers, for instance.
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More than 300 guests from tyre manufacturing, wholesale, distribution, retail and the associated automotive aftermarket have already booked for the 90th NTDA Annual Dinner, sponsored by Land Tyre Service, to be held at the ICC Birmingham on Thursday 3rd October 2019.
Confirmed 2019 sponsors so far are Maritime Cargo Services, Land Tyre Service, Sailun Tyres, Jelf Beaumont, The Parts Alliance, Trelleborg Wheel Systems, Continental Tyre Group Ltd, Pirelli Tyres Ltd, Hankook Tyre UK Ltd and the Worshipful Company of Wheelwrights.
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text:
Budget debate heats up as new report to update surplus
Latest economic report will tell lawmakers if they have more or less surplus money
Budget debate heats up as new report to update surplus Latest economic report will tell lawmakers if they have more or less surplus money Check out this story on sctimes.com: https://www.sctimes.com/story/news/local/minnesota/2015/02/25/minnesota-budget-debate-heats-new-report/23986777/
ASSOCIATED PRESS Published 8:01 a.m. CT Feb. 25, 2015 | Updated 8:03 a.m. CT Feb. 25, 2015
Legislation(Photo: Times graphic)
ST. PAUL – The budget-setting preseason at Minnesota's Capitol is about to give way to the session's full-blown debate, helped along by an economic forecast that guides tax-and-spending parameters.
Friday's release of the comprehensive report will determine whether Gov. Mark Dayton and the Legislature still have a projected $1 billion surplus at their disposal — or if it's gone up or down since the last look in December. The forecast is the final one before the Legislature adopts a new two-year budget, probably in May.
Until now, only Dayton has put a full $42 billion budget plan on the table. In coming days and weeks, the Republican-led House and Democratic-held Senate will sketch out competing plans.
Here is a primer:
WHAT'S THE FUSS ABOUT?
Twice a year, state finance officials and economic advisers compile a raft of state, national and global economic data. Employment and wage trends, consumer spending patterns, short- and long-term fuel costs and corporate profits are among the details analyzed and turned into wavy-lined charts.
They use it to estimate what Minnesota tax collections and spending will be for years into the future, absent changes in state policy.
While it's an educated guess, the projection takes on enormous weight. When times are bad, it determines how big of a budget hole lawmakers must fill in because the state Constitution requires a balanced budget. When times are better — as they've been lately — it's the stash of money that can cover tax cuts, extra school aid or brand-new programs.
WHAT'S IN THE WIND?
Recent signs give state leaders plenty of reason for optimism that the surplus will swell.
Minnesota's unemployment rate was already tumbling when the previous economic report was done, but it's down even more lately — to 3.6 percent. Wages were fairly static at last check, but more recent reports show the strongest uptick in years. Consistently low gas prices gave people room to spend elsewhere, which could drive up sales tax collections. In January alone, Minnesota took in $85 million more in all taxes and fees than expected.
But remember, this isn't only about what has happened in the last few weeks or months. The report looks four years into the future to assess what lawmakers might be up against. Projected inflation, which has been low, is expected to creep higher in coming years. Economists are still keeping an eye on rising health care costs and an aging workforce, all of which could put additional pressure on government budgets.
WHERE MIGHT EXTRA MONEY GO?
Given the rush by interest groups to claim a slice of the previously forecast $1 billion surplus, expect a new stampede if more money is heaped on top.
Dayton will submit a supplemental budget soon. When he released his original budget, Dayton said a stronger forecast would allow him to recommend more money for long-term care and nursing homes. Local government groups are hoping he'd boost funding for municipal and county aid programs.
Some of the cash could be carved off to pay for transportation or other public-works construction projects.
Republican House Speaker Kurt Daudt said it's safe to assume that some of the surplus will be earmarked for tax relief. "I don't know what that looks like yet," he said.
Democratic Senate Majority Leader Tom Bakk said more cushion would make it easier to fit wide-ranging higher education proposals in with Dayton's focus on early learning through high school.
WHAT IF THERE'S LESS?
There are already many more requests than dollars to go around, so expectations would have to be significantly lowered.
It's a different calculation for legislators than it is for Dayton because neither majority party in the House or Senate has given a full budget rundown. For Dayton, it would be all about subtraction.
Read or Share this story: https://www.sctimes.com/story/news/local/minnesota/2015/02/25/minnesota-budget-debate-heats-new-report/23986777/