It's your first day as the new member of the Youth Offending Team and you are understandably a little nervous. This is when you meet new colleagues, adapt to office working practices, get to grips with the local area, the culture, the demographic, and even some of those odd-sounding acronyms.
Following on from last week's blog about how to find a role with a Youth Offender Team, this week we'll be helping you to get started as part of a team which will see you aiming to prevent children and young people under the age of 18 from offending, or re-offending. It doesn't have to be that daunting and if you go into the role with an open mind, know the type of questions you need to be asking, and have a willingness to learn from those around you, you'll be getting off to a great start.
A good number of your new colleagues will have been in the job for a number of years and as a result they will have wide experience, which will prove invaluable to you. You can't beat picking up good tips from the more experienced personnel around you.
Be prepared to shadow your colleagues; watch how they communicate with different clients, and how they handle potentially difficult discussions and conversations. Don't be afraid to ask questions – however basic you feel they are - because if you don't know the answer, the sooner you find out the better.
Some of the practices and procedures within the Youth Offending Team you join may subtly differ to what you expect, or there may be acronyms and abbreviations the office uses that you are not familiar with. Ensure you get up to speed with those at the earliest opportunity and, again, don't be afraid to ask your new colleagues. Also, use the resources available to you and take a look at the literature in the office to help you evolve and continue your learning process.
Be prepared to talk through difficult situations with colleagues and your managers, or even with your fellow trainees who may be having similar concerns or questions as you.
Talking issues through with co-workers can help you develop and mature as a practitioner and is also good for sharing knowledge and experience.


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$30K fine for first conviction under Copyright Act
Article Published: February 26, 2014
ST JOHN'S, Antigua – Giancarlo Bettini, owner of offshore Antigua-based software developer Slysoft Inc, has been fined $30,000 after being found guilty of all six charges brought against him under The Copyright Act.
He was fined $5,000 on each count. This is the first time that someone is convicted for such an offence since the law was passed in Antigua & Barbuda.
Magistrate Ngaio Emanuel ordered Bettini to pay the fines immediately on two of the counts, or serve six months in prison on each of the two counts.
The sentences would run consecutively, in other words, the total time in prison would be 12 months.
The fines on the other four counts are to be paid by April 30 and if those are not paid by then, he would be jailed for six months on each count.
However, these sentences would run concurrently.
Meantime, the magistrate reprimanded and discharged Bettini's company, Slysoft Inc, on the same six charges brought against it.
Subsequent to the recent ruling against Bettini, his lawyer Dane Hamilton QC immediately filed a notice of appeal so the judgment has been stayed.
Bettini and his company Slysoft Inc were charged for offences under The Copyright Act, No 22 of 2003 of the Laws of Antigua & Barbuda, under Section 46(6) (a) which states, "Any person who manufactures or imports into Antigua & Barbuda for sale or rental any device or means specifically designed or adopted to circumvent any device or means intended to prevent or restrict reproduction of a work, a phonogram or a broadcast or to impair the quality of copies made commits an offence and is liable on conviction to a fine not exceeding $10,000 or to a term of imprisonment not exceeding two years."
And, Section 46(7) (a) which says, "Any person who removes or alters any electronic rights management information without authority commits an offence and is liable on conviction to a fine not exceeding $10,000 or to a term of imprisonment not exceeding two years."
Advanced Access Content Systems (AACS/LA) Iicensing Administrator of the United States (US) raised the red flag and informed local authorities back in 2010.
After investigations were conducted locally, the police filed the complaint that year.
(More in today's Daily OBSERVER)
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Disney Cruise lines return to A&B's shores
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The demand for new cars in the country has been decreasing for the past two years, but one section of the market is holding steady. General Manager of Antigua Motors…
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ST JOHN'S, Antigua - Minister of Civil Aviation John Maginley has backed LIAT's imminent plan to cut unprofitable routes, wherever they might be - including…

redpajama_set_name: RedPajamaCommonCrawl


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About Connie TANG
But we are proud to say that Connie TANG contributed 7 entries already.
Entries by Connie TANG
Dosing issues with DOACs in Asian real world setting
23rd December 2021 /in Oncology/by Connie TANG
Sotorasib approved as the first targeted therapy for KRAS-Mutant Lung Cancer
22nd November 2021 /in Lung Cancer, Oncology/by Connie TANG
Lung cancer is one of the leading cancers in Hong Kong, accounting for 26.4% of cancer mortality in 2018. Approximately 80% of the lung cancers are non-small cell lung cancer (NSCLC).
Amivantamab in combination with Lazertinib showed efficacy in NSCLC
Non-small cell lung cancer (NSCLC) accounts for 80-85% of all lung cancer. The most frequent genetic mutation harboured in lung adenocarcinomas occurs in the epidermal growth factor receptor (EGFR), accounting for 40-55% in Asian patients.
Gender-related differences in safety after switching to BIC/TAF/FTC
3rd November 2021 /in AIDS, HIV, Infectious Disease/by Connie TANG
Human immunodeficiency virus (HIV), one of most serious public health challenges in the world, has already affected approximately 37.6 million people across the globe in 2020 and new infections in 2020 are estimated to be 1.5 million. Bictegravir/ Emtricitabine/ tenofovir (BIC/TAF/FTC) is a fixed-dose combination tablet consisting of an integrase inhibitor and two nucleoside reverse transcriptase inhibitors for the treatment of HIV infection. This HIV medication was approved by the United States Food and Drug Administration (USFDA) in 2018 due to the excellent efficacy outcomes in clinical trials. Real-world safety data of BIC/TAF/FTC was presented at the 18th European AIDS Conference in 2021 and summarised below.


It takes hard work to get a flat belly but it isn't impossible and if you heed these tips and tricks, you will be on your way to a flatter belly in no time.
These tips and tricks aren't going to magically work on their own, you have to be consistent if you want lasting results. Please note, these tips and tricks are tried and true and are not gimmicks. Gimmicks and fads are temporary.
Here's what you can do to find yourself with a flat belly in no time.
Bad stress can negatively impact your health. Chronic stress can begin to breakdown the body physically and no one wants that.
Stress also produces a hormone called cortisol which promotes fat storage in the belly. You don't want that so the best remedy is to find ways to de-stress daily.
De-stress which comes in all shapes and forms. Some popular methods to de-stress include deep breathing, meditation and yoga.
A side benefit of the deep breathing is, it promotes fat oxidation – that's right, burn fat while de-stressing. SCORE!
This is another de-stress method to remove stress and strain from the body. A good body massage not only helps to reduce stress, but can support healthy body detoxification.
An abdominal massage is a great way to de-stress yourself.
Abdominal massages trigger your internal system to detoxify the body to help alleviate digestive issues such constipation and bloating which can lead to a big belly.
You can get an abdominal massage by a massage therapist who would put pressure on your abs and belly. If you cannot book time with a professional massage therapist, a portable massager is a must-have, and you will notice a positive change in your body and belly area.
Daily cardio not only improves heart health, it boosts the body's metabolism and fat burning capacity. Even though you can't spot reduce fat from your belly, decreasing overall body fat will eventually result in decreased belly fat to reveal flatter abs.
To maintain your body and existing flat abs, perform steady state cardio 30 minutes, 5 days a week or a total of 150 minutes of cardio weekly.
If you want immediate flat belly results increase the intensity with intervals for 75 minutes a week for example, walk 30 seconds, sprint 30 seconds and repeat a total of 30 minutes.
Whatever you do, get the heart rate up so that your body starts using your excess body fat for fuel and burn it. Over time you will notice your belly flattening.
This can't be said enough, abs are made in the kitchen! No amount of exercise such as crunches will outweigh a poor diet.
Nothing packs on the excess fat around our bellies faster than eating high fat, sodium and sugar foods such as fast and highly processed food as well as not eating on a regular schedule.
Irregular eating habits wreaks havoc on your metabolism which may slow down because your body is attempting to preserve energy (calories) because it doesn't know when it will eat again.
That can store as fat around your belly.
Additionally, consuming high amounts of low-nutrient food commonly found in fast and processed food, is difficult for the body to digest and metabolize properly which can slow down your digestion causing belly bloat.
Eat well portioned real food throughout the day which not only keeps your metabolism stoked so it is constantly burning body fat but to manage blood sugar levels so you don't get ravenously hungry and overeat.
Your soon-to-be-revealed belly will thank you for it.
It is said that if you completely cut out consumption of processed sugar from the foods you eat daily, you do not have to do anything else to lose that excess fat covering your abs.
Check out Sherrie Shepherd who went 260 days without consuming added sugar. She looks fabulous and her belly is very flat.
Sugar causes belly bloat plus a host of other issues such as inflammation.
Not only should you avoid sugar added to food, but also sugar-coated processed foods which includes candy, cakes, donuts (plain, jelly and glazed) and soft drinks.
All of that food tastes really good because of the added sugar, which is addictive, but it causes havoc on the body over time.
Obvious foods like cake and candy aren't the only foods to look out for, as sugar is hidden in a lot of other foods like condiments such as ketchup, breakfast and energy bars as well as frozen food.
Sugar is a low-nutrient, high calorie substance that you will want to avoid if you want a flat belly.
Slowly reduce the amount of sugar consumed daily to start to see a noticeable flattening of your belly.
Waist beads are not only popular but they are a great, non-scale way to measure how fast your belly flattens. This is how they work, you first get a set which sits high on your waist vs. down around your hips.
As you lose weight they begin to drop down your abdomen getting closer to your hips. If you begin to gain inches around your waist, the waist beads will begin to feel tighter.
When this happens make sure you are consuming food with fiber to help flush out any waste from your digestive system which could be causing bloating.
Use waist beads to also manage how much you eat. As you sit down to eat a meal be conscientious of how the beads feel around your waist. While consuming your meal, as the beads feel tighter because your stomach expands stop eating.
That not only helps with portion control, it puts your body in a caloric deficit which burns excess fat from your body including your belly. WIN!
We went through and shared some tips and tricks to help you flatten your belly. If you are consistent with these methods you will realize a flatter belly in no time.
Which of these methods do you plan to try or do now?
Sara is a psychologist by profession, and she loves massage therapies as well as home-based work and travelling. She is obsessed with massage chair therapies and other relaxing techniques. She regularly writes blogs at Mymassagechairs.
4 Replies to "Flat Belly Tips and Tricks"
Hi Admin, I just wanted to let you know how much I enjoyed this article. I am happy that you just shared this helpful info with us. Thanks for sharing.
Very well written article. Keep up the good work. I cannot wait to read more posts. Really looking forward to reading more.
Firstly thanks for Author. I have read the post. It better tips for health. Have an article of belly in your home. So, can you study, then try the way. Massage & physical exercise never die!!! it almost do helps your health.


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Working in the music and event industry for 15 years, David brings unmatched expertise to each and every event he works. David got his start working in commercial radio before serving 6 years honorably in the US Air Force. David began moonlighting as a DJ in the early 2000's, he then relocated to Virginia and began operating DV Entertainment full-time in 2010. He also studied music at College of Charleston. David is dedicated to bringing the highest quality services to every client the event industry has to offer.


Eat, drink, and be ready for selfies.
1. To pick your perfect outfit, figure out which colors look best together.
Whether you're stressing about a look for Thanksgiving, the office holiday party, or New Year's Eve, make mixing and matching super simple by pairing up the right hues.
2. And stick to colors that make sense for the season.
Look for shades that have darker undertones for the perfect holiday vibe.
3. If you're looking to get *festive* with a plaid, make sure you know which one.
Knowing your plaids will make shopping SO much easier.
Godet skirts are pretty and formal, perfect for your upcoming events.
A classic sheath dress is perfect for dressing up or down around the holidays, especially if you're going to be traveling.
Ruffle and tie-neck collars are super romanic while tuxedo and notched are slightly more classic.
7. If you're going to rock a button-up, master the art of rolling your sleeves.
The art of cuffing is truly amazing. Read more about the tutorial on Who What Wear.
8. If you're wearing boots with your holiday look, tuck them in like a pro.
Stay warm and cozy AF.
9. Before you go shoe shopping, add these terms to your arsenal.
"T-strap peep-toe D'Orsay platform" is a lot more concise than "Heels that aren't too high (but are high enough) and won't kill my feet, but also have a strap so my foot doesn't fall out if I slip on ice."
10. To filter your shoe search even more, know exactly what heel shape you're looking for.
Now you can clarify that you want an Italian heel, not a pin heel.
11. Learn how to iron your shirts ~efficiently~ so you don't show up to your mom's house looking like a wrinkled mess.
Your fam expects more from you.
12. Find the perfect necklace depending on your neckline.
Since a cowl neckline has more interest, keep the necklace small and simple. For a décolletage-bearing neckline (like a V-neck), you can opt for something bolder.
13. And if you're shopping for necklaces online, know what length to get.
You know that necklace you're eyeing on Etsy that'll go perfect with your Christmas outfit? Make sure the length is *just* right.
14. In a pinch, you can turn your dress into a skirt.
15. And lastly, know how to remove stains so that you don't ruin your clothes within a few hours.
Get it, you damn stylish thang.


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NIH hospital's pipes harbored uncommon bacteria that infected patients
By Ike Swetlitz
NIH Clinical Center in Bethesda, Md. NIH
Patients were infected with antibiotic-resistant bacteria living in the plumbing of the National Institutes of Health's hospital in Bethesda, Md., contributing to at least three deaths in 2016.
A study published Wednesday in the New England Journal of Medicine found that, from 2006 to 2016, at least 12 patients at the NIH Clinical Center, which provides experimental therapies and hosts research trials, were infected with Sphingomonas koreensis, an uncommon bacteria. The paper, written by NIH researchers, suggests that the infections came from contaminated water pipes, where the bacteria may have been living since as early as 2004, soon after construction of a new clinical center building.
This report is the latest instance of pathogenic contamination at the NIH, an issue that has roiled the highest ranks of the agency in recent years. The Clinical Center was the site of a superbug outbreak in 2011, and fungi were found in drug vials in 2015. After a scathing April 2016 internal report concluded that NIH researchers sometimes put patient safety at risk, Director Francis Collins replaced the top leadership at the Clinical Center.
However, infections like this are not uncommon in medical centers — the Centers for Disease Control and Prevention estimates that about 4 percent of hospital patients pick up diseases from the hospital environment.
"It is not exceptional for a hospital to have a [hospital-originating] infection," Dr. Tara Palmore, hospital epidemiologist at the Clinical Center and one of the study's authors, said in an interview. "They occur in every hospital."
Controversial NIH study of 'moderate drinking' will be terminated after scathing report
Wednesday's paper is the NIH's first broad disclosure of the Sphingomonas koreensis infections. Palmore said information about the infections was presented at a 2017 scientific meeting and at an NIH lecture that was broadcast online.
"Scientific publication is one way of many to discuss information – and always has a lag time," she said through the spokesperson.
According to the paper, the hospital became aware of the problem in 2016, when six patients at the Clinical Center came down with similar infections over the course of six months. They were all infected with a type of Sphingomonas bacteria, which live in water. Four were infected with the drug-resistant Sphingomonas koreensis, and three of them died.
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It's unclear whether Sphingomonas koreensis is what killed those patients, who had undergone stem cell transplants, which leave patients vulnerable to infections.
"The three patients who died also had multiple other life-threatening conditions, which were complications of their underlying disease," Palmore said.
"[Sphingomonas koreensis] are fairly weak bacteria," she said. "But in a patient who is highly immunosuppressed, it doesn't take a highly virulent bacteria to cause additional illness."
The cluster of Sphingomonas infections prompted researchers to search the hospital's water infrastructure to see where the bacteria might have been hiding out. They found Sphingomonas koreensis living in water that came out of the faucets in patient rooms, as well as inside the sink faucets themselves.
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The paper details some changes that were made to the Clinical Center's water system after the cluster was discovered, including increasing the temperature of the water and adding more chlorine. Palmore said the low chlorine level was identified and fixed in a matter of days.
She added that the staff at the Clinical Center are still experimenting with different configurations of water pipes — "literally taking out plumbing and putting it in a different shape" — in an effort to minimize the amount of bacteria that can grow in the water system.
"It's a long-term project in our hospital that proceeds at a slow pace because we can't turn the entire hospital into our laboratory," Palmore said.
No new Sphingomonas koreensis infections have been reported at the Clinical Center since 2016, when the changes were made.
This story was updated with comments from Dr. Tara Palmore.
Louisabt says:
As in the Food Inspection program, everything must be tested for microbial contamination, or at least it should be. Both air and water.
This should be kind of concerning, after all it was the NIH. Local hospitals are even worse. In many cases the filth is visible, blood, mucus, and fecal matter, left behind by hurried cleaners, is the norm. Even more concerning is the refusal of local media outlets to cover this serious safety matter.
Nurses change beds, the cleaners do not. The cleaners do an amazing job in all hospitals I worked at. They are paid a pittance and there's often just the one person per ward,cleaning and going round with the meals cart. I'd agree they suffer from understaffing and no support network and more need to be hired.
There's many policies in place to prevent hospital acquired infections and test patients for them,cleaners are but a small part of. I do encourage you to read up on cleanliness champion if you want to know more. Cleaners are not at fault here and even if they contributed to the issue, it's a complex matter to do with water structures, staffing levels, infection control and etc.
Ron McCune says:
Bleach is the one thing that kills many kinds of germs. ALL hospitals and medical facilities should be putting bleach into their drains of all kinds. They should also take a large cup of bleach and soak every faucet in a cup of bleach. But most of all medical facilities have got to get better at cleaning their facilities with germ killing bleach. I have been in numerous health facilities over the years and I've seen dried up blood spots on many health facilities walls, beds and most anything else in their facilities which told me that the people charged with cleaning those facilities aren't doing a good job when in fact they should be doing a thorough job in cleaning everything. When was the last time you ever saw a cleaning person cleaning walls and EVERYTHING else in medical facilities. Germs love medical facilities because there is so many places to be without being destroyed in some way because no one ever gets around to cleaning the environment where germs live. We have got to stop this by requiring that ALL medical facilities hire EXCELLENT cleaning services that will clean every inch of the medical facilities. It's obvious that the cleaning personnel that we currently have cleaning our medical facilities aren't doing their jobs right. It's obvious that we have to have better cleaning of our medical facilities! It's obvious that the medical community has no interest in doing their cleaning job right so let's start making laws that require them to do so for our own good!
Dan Potterf says:
Research demonstrates biofilm and the bacterial pathogens residing there are highly resistant to traditional disinfectants. Bacteria in Biofilm may be as much as 500 times to 1,000 times more resistant to sanitizing chemicals than free-flowing (planktonic) cells of the same species. Chemicals are creating antibiotic resistant organisms…..
HOW do you not know that it is the National InstituteS of Health?! That is incredibly embarrassing.
Mark Thorson says:
In addition to sanitizing their pipes, they should pay attention to dead legs in the plumbing. These are sections that are not used frequently, like a faucet that is seldom used. Bacteria can live in those things and get into the main water stream. This is a problem for homeowners too — like if you have a sprinkler system that only gets used in the summer but is dead all winter. Legionnaire's Disease is the major risk. In the home, you might have legs that were used for a dishwasher or washing machine that isn't there anymore. Also, the icemaker on a refrigerator. All legs need to be flushed regularly.
Somebozo says:
Niher here. Good advice about dead legs. I have always had concerns about that drinking fountain in the middle of the hall, use the fountain near the restrooms!
New clues on why women's Alzheimer's risk differs from…
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Case Description: If you missed our most recent TB Case Discussion, you can view it on-demand HERE. Click "Read More…" for a complete list of archived cases.
a.Even with many exposures since 2005 this patient who has been on steroids for a long period of time,tests positive for LTBI in 2013.Should we look at more recent exposures.
b. An individual on steroids driving a patient with MDR TB amounts to significant exposure. Being a health care professional did she take any precautions? Routinely we consider household contacts to be at considerable risk of TB, but travelling with an open case of TB could pose similar risk with individuals close to each other, varying degrees of ventilation(windows open or closed/AC on or off),overcrowding in public transport, poor cough etiquette. How much risk will a single exposure in such circumstances pose for acquiring TB?
1. Was any work up done to identify the cause of hypogonadism (which appears to be secondary hypogonadism). Could this be related to the fibrotic disease?
what about phenotyping of this patient ?


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Old Brighton Road South, Pease Pottage, Crawley, West Sussex
Asking Price £1,500,000
Hunters Moon is a well-proportioned detached 1920s residence with versatile accommodation of 5500 ft.² plus several outbuildings occupying mature gardens and paddocks of 7 acres at the end of a long driveway adjoining countryside which the present owners bought over 20 years ago when they extended the house and carried out several improvements although general updating is now required.
The accommodation offers great flexibility and would suit an extended family, those looking for home working space or alternative use subject to the necessary planning consents. The South Wing is approached through a grand reception hall and comprises some wonderful living rooms and bedrooms above and the North wing was added to create a first floor one bedroom flat and a ground floor wing for many dogs. The grounds: The property is approached over a long driveway and electronic gates which lead into a gravelled parking area which leads round to the front of the house. The beautiful and mature gardens surround the house and there are garages, large storage sheds and a studio/office building, both offer great potential for conversion into separate detached dwellings STPP. To the south and east of the house there are several Paddocks and stables. The owners were previously trying to sell the property with just 3.18 acres but have now decided to sell the property as a whole and are aware that there are planning possibilities. They have been approached by several developers and Pease Pottage is currently having a large-scale developments and new primary school built on the eastern side of the village. (other side of the A23) The property is currently outside the redevelopment area although with the many developments being granted planning consent in the county, we would envisage redevelopment potential is likely in years to come. A developer has shown great interest but wanted a 10-year optional for redevelopment which the owners are not prepared to consider. They are happy to sell the property with no covenants or overage agreements giving an incoming purchaser the freedom to consider all development possibilities. Read more
The accommodation offers great flexibility and would suit an extended family, those looking for home working space or alternative use subject to the necessary planning consents. The South Wing is approached through a grand reception hall and comprises some wonderful living rooms and bedrooms above and the North wing was added to create a first floor one bedroom flat and a ground floor wing for many dogs. The grounds: The property is approached over a long driveway and electronic gates which lead into a gravelled parking area which leads round to the front of the house. The beautiful and mature gardens surround the house and there are garages, large storage sheds and a studio/office building, both offer great potential for conversion into separate detached dwellings STPP. To the south and east of the house there are several Paddocks and stables. The owners were previously trying to sell the property with just 3.18 acres but have now decided to sell the property as a whole and are aware that there are planning possibilities. They have been approached by several developers and Pease Pottage is currently having a large-scale developments and new primary school built on the eastern side of the village. (other side of the A23) The property is currently outside the redevelopment area although with the many developments being granted planning consent in the county, we would envisage redevelopment potential is likely in years to come. A developer has shown great interest but wanted a 10-year optional for redevelopment which the owners are not prepared to consider. They are happy to sell the property with no covenants or overage agreements giving an incoming purchaser the freedom to consider all development possibilities.
Location: The property is located about half a mile to the south of the village off the Old Brighton Road (south) which is a no through road running along the east side of the A23. There is one neighboring property accessed off the same driveway and to the south of the property is a care home which currently includes a large building which we believe might be redeveloped. Pease Pottage is an expanding village just off the A23 2.5 miles south of Crawley, 7 miles south of Gatwick Airport, 6 miles east of Horsham, 9 miles north/west of Haywards Heath and 20 miles north of Brighton. The village has a good local pub / restaurant, A motorway services with several food outlets and 24 hour petrol station. Beautiful countryside including St Leonards forest and the Tilgate forest are close by interspersed with footpaths and bridleways (a permit can be obtained from South East Toll rides for some private riding locally). Schooling. Children from the village fall into the catchment area for Handcross County primary and Warden Park secondary academy in Cuckfield. A footbridge from the Brighton Road South, nr the entrance to the property leads over the A23 making it possible to walk to Handcross and children can catch a bus to Cuckfield (Tilgate Forest Row stop - www.metrobus.co.uk). There are also secondary schools in Crawley and Horsham. The local area is also well served by several excellent independent schools including Handcross Park, Cottesmore, Worth Abbey and Ardingly College. Many of the independent schools run a school bus service. Directions. From Junction 11 of the A23 follow the signs for Services/ Pease Pottage. Past the services on your right hand side and at the next roundabout turn right and continue over the A23 and turn left opposite the Black Swann pub into Old Brighton Road South and proceed south parallel with the A23 away from the village and the driveway to Hunters Moon Will be on the right hand side after approximately half a mile. For individual directions please contact the owner's sole agents. Services: mains of water and electricity, oil forest central heating, solar panels, private drainage.
Large home in 7 acres of secluded gardens and grounds rural Setting to the south of the village (East of A23)
Versatile accommodation with 1st floor flat/annex Several outbuildings with conversion possibilities STPP
The land and property has re-development potential STPP A wealth of character features throughout
The property would benefit from general updating Great vehicular access to Gatwick Airport, Brighton and London (M25)
Within easy reach of good local and independent schools Council Tax Band 'G' and EPC 'E'
7 Muster Green
RH16 4AP
E-Mail: hh@mansellmctaggart.co.uk


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What is Cerebral Hypoxia?
Without sufficient oxygen, a person can slip into a coma and suffer permanent brain damage.
People who have had a stroke may have difficulty walking.
Patients who have had a stroke may require a cane to walk.
Drowning may be the cause of cerebral hypoxia.
Hypoxia treatment may involve giving a patient oxygen.
A nasal cannula may be used to administer oxygen to a patient suffering from hypoxia.
Focal hypoxia refers to a localized decrease in oxygen levels, and is often related to an aneurysm.
Oxygen bars may be located at places at high altitudes to help increase a person's supply of oxygen.
Choking can lead to cerebral hypoxia.
Written By: Daniel Liden
Edited By: Jenn Walker
Images By: Gwimages, Photographee.eu, Praisaeng, Anton Sokolov, Lisa F. Young, Sudok1, Joshya, n/a, Nebari
Cerebral hypoxia is a medical term that refers to an insufficient supply of oxygen to the brain. In a strict technical sense, the term refers to a lack of oxygen in the outer area of the brain, or the cerebral hemisphere. It is generally used, however, to refer to any general lack of oxygen supply to the brain, regardless of where the specific lack is located. Prolonged cerebral hypoxia kills brain cells as they need oxygen to sustain themselves properly. Long-term hypoxia, then, can lead to severe cognitive and motor impairment or even death as a result of severe brain damage.
There are four main categories of cerebral hypoxia, organized by severity. The first, diffuse hypoxia, refers to a mild decrease in brain function as a result of decreased oxygen levels. Focal hypoxia refers to a localized decrease in oxygen levels and is often related to a mild stroke or aneurysm. A transient ischemic attack, also known as a mini-stroke, is a localized hypoxia lasting less than 24 hours that results in neurological impairment. Massive cerebral infarction occurs when blood flow to several areas of the brain is stopped; this is also referred to as a stroke.
Symptoms of cerebral hypoxia can be physical or neurological in nature and tend to vary greatly based on the severity of oxygen deprivation. In mild cases, individuals tend to demonstrate poor judgment and may be generally inattentive. They may also have motor difficulties, finding it much more difficult than usual to complete normal actions such as walking and holding onto objects. In particularly severe cases, the individual may slip into a coma and become completely unresponsive to and unaware of all stimuli. A coma can, in severe cases, be accompanied by complete loss of breathing.
If severe cases of cerebral hypoxia are not treated immediately, death is likely. In cases in which pulse and blood pressure remain normal but the hypoxia victim is otherwise unresponsive, complete brain death may have occurred. In such cases, there is no hope for restoring the victim to any semblance of complete and normal functionality.
Cerebral hypoxia can be caused in many different ways. Some causes are related to external factors such as drowning or excessive smoke or carbon monoxide inhalation. These can lead to asphyxiation if regular air flow is not returned quickly. Internal factors that can lead to cerebral hypoxia include stroke, cardiac arrest, low blood pressure, and paralysis of breathing muscles.
What Is a Hypoxia Inducing Factor?
What Is a Hypoxic Chamber?
What Is the Difference between Anoxia and Hypoxia?
What Is a Shallow Water Blackout?
What is Apnea of Prematurity?
What is the Cerebral Hemisphere?
What is the Falx Cerebri?
WaterSerpent
@ Bronze Eagle
I've always heard it's somewhere around 4 minutes? Seriously though, there's so much we don't know about the brain. There's a fairly new study where comatose patients are using computers to communicate their needs. Even when we think someone is gone, they may not be in some cases?
BronzeEagle
@ Sun Seal
I'm interested in this too, for different reasons but how long does cerebral hypoxia have to last for brain death to occur?
SunSeal
My mother has had a number of mini-strokes. Her only real issue is with depth perception and when she gets tired it's like she can't make sense of words as well as she normally can. She always tells me that everything will be fine, but what are the odds of a full blown stroke after having mini-strokes?


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Wisdom// February 14, 2019
3 Clear Signs That You're Ready For A Managerial Role
There are distinct indicators.
Praveen Tipirneni
Mint Images/ Tim Pannell / Getty Images
People are often promoted into managerial positions because they're extremely good at the technical jobs they initially held.
It's a natural progression — you're good at doing a specific job, so you'll probably be good at managing other people who do it.
But technical competence isn't perfectly correlated with managerial competence.
Many people accept the transition to a manager as a default — they simply feel like it's time. Or they feel as though they've reached the top of the technical ladder, so they want to jump to a new ladder and start climbing again.
I don't think either of those options is a particularly good reason for becoming a manager.
If you're given the opportunity to transition from an individual contributor role to a managerial position, I'd advise you to think carefully about why you're making the move.
There's nothing wrong with staying in your current role if you don't have any reasons to become a manager.
To help you avoid being unsure of yourself when offered a managerial position, I want to share my perspective on when to take the leap.
Here are three ways to tell if you're ready:
1. You have a vision of what you can accomplish for the company as a leader.
Ideally, you should have an internal motivation to become a manager.
This motivation usually comes in the form of a vision for your team or an urge to improve a process within the company. It can be helpful to take a moment to think about what occupies your thoughts while at work.
If you regularly find yourself thinking, "There's a better way to do this," then you may be mentally ready for a managerial position.
The key is that you have some sort of larger vision. It could be about improving your team or the company goals — and it doesn't have to be perfectly clear right at this moment. But you need to have a feeling that what you're trying to accomplish is larger than the requirements of your individual role.
If you really feel like you can offer the company more as a manager, that's a sign you're ready for the transition.
2. You're willing to develop a broader set of skills.
Everyone who transitions into a managerial role has the same initial fantasy: "I'll be able to stay up-to-date with all the technical aspects of my last role."
Unfortunately, that's not realistic. Managers don't have time to stay as technical as individual contributors. And eventually, you'll actually become less skilled in whatever it was you were doing.
The good news is, this regression doesn't make you less effective.
Instead of constantly learning about every new development in your field, you're learning new disciplines and gaining a broader base knowledge. You're becoming effective in a different way.
The reality is, some people don't want to do that.
It's okay to be committed to your specific discipline and decide you want to concentrate on it exclusively. But if you're ready to gain a broader set of skills — to build a wide base of knowledge instead of a deep understanding — then the time may be right to become a manager.
3. You can't realize your ambitions alone.
Before I took my current role as CEO of Morphic Therapeutic, I spent a lot of time on self-reflection. I was trying to uncover my passion and decide what my next step would be.
I came to realize that I really wanted to help build a scientific culture. I had a particular workplace in mind, and I wanted to see it come to fruition. I knew the only way I'd be able to have a hand in building that was by working at a company that was starting from scratch.
No ingrained habits, no established culture to fight. A blank slate.
I also knew the only way I could realize my vision was through leading and managing other people.
I couldn't do it as a single contributor within the company. I needed the help of an entire team to make it happen.
And I think that's really what a managerial leadership role is about: executing on an idea you can't accomplish by yourself. You don't necessarily need to know where it's going, but you must have ambition. There's no reason to become a manager without some kind of aim to accomplish a goal that's bigger than your own abilities.
If you have the sense that you're working towards something more important than your individual contribution, then you're likely ready for the transition to a managerial role.
Originally published on Medium.
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— Published on February 14, 2019
Career growth,
syndicated,
Well-Being,
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For insight into the biotech industry and building a strong startup team, follow me on Quora and Twitter.
Wisdom// August 10, 2017
Hey Millennials, Here's The Ultimate Guide to Managing People
by Karen Schneider
// September 6, 2018
If You're Looking to Change Roles at Work, Here's How to Stop Doubting Yourself
by Glassdoor
The Valuable Truth About How To Leave a Job
by Valerie Martinelli, MPA


Li who finds love, Mei Li Ren Sheng, Love and Life and Lie, Meeting Mr. Chinese symbols for life, save someone's life. But when an accident occurs, Xin Tong and her mother are forced to move into the home of the wealthy businessman Ji Bai Jun. The ox has always been one who puts their job before everything else. Relaxation is who you are. Single Horses that make the round of parties and introduce themselves around will be successful in romance.
According to the Chinese Astrology Stem-Branch Calendar, 2019 is Ji Hai. You are also interested in our Your Comments. I do and I understand. Hold your hand, and grow old with you. Health condition is good, but they need to be careful when playing beside lakes.
There are plenty of acquaintances in the world; but very few real friends. Chinese symbols for life, love, lust, spring. So here is my advice…. Chinese symbols for life, anima. With Reverso you can find the English translation, definition or synonym for love life and thousands of other words.
The balance between obstacles and triumphs which the lead couple go through was way out of balance in the negative therefore you got tired of seeing them go through problem after problem with no decent solution. Artistic venues are especially good places for your creative sign to meet someone special. Based on the Horse fortune in 2019, their careers develop smoothly in the whole year with enough efforts and hard work. See what this stabilizing time has in store for you by reading your Chinese sign's horoscope below! Going back to the tattoo shop, he found out it had closed. It was Gu's third film as director after a lengthy career as a cinematographer for some of China's top directors.
Soon after, Deyi goes to ask the Village Head to come out for his meal, but instead discovers that he has died on his bed, clutching the diary in his hands. Love is on your horizon! Sheep Love Horoscope The Sociable Sheep may be challenged to find love in the Year of the Brown Earth Dog. Then, as the Year of the Brown Earth Dog winds down, you can decide which admirer best suits your needs. There, Xin Tong lives with the two Ji kids, the spoiled Zhi Zhen Ye Qing and the sweet Zhen Yu Jia Jing Hui , and also meets their friend, Li Yao Nan Chen Xiao. Backed by the government, the film is said to be the first time the has been featured in mainstream Chinese culture. Instead, a second theft occurs, and this time it is the Village Head who has his precious lifelong diary and some money stolen.
Rooster Love Horoscope The Year of the Brown Earth Dog should be lucky in love for single Roosters. For example, the red agate could exorcise evil spirits in Ben Ming Nian One's Zodiac Year and Daily Life; The rose quartz and amethyst could help to attract love. Tigers who announce a desire for romance will fare very well. Single Dogs that are looking for someone new may decide to steer a friendship into romantic waters. Deyi finally falls asleep with a cold Qinqin in his arms.
Tiger Love Horoscope You enticing Tigers should have no trouble attracting love in the Year of the Earth Dog, provided you put yourself on the market! It will be easy for them to have progresses in study and get great grades in important exams. It snuck into our village softly and everyone who got it died like falling leaves. Dwelling on an ex can block a more appropriate partner from your door. Rather than imposing standards of perfection on your mate, use this time to be more generous and compassionate. Monkeys who commit to being better mates will experience exciting breakthroughs. However, there may be some unexpected expenses in daily life. Rabbits that are already in relationships should take a direct approach to love.
Lao Zhuzhu is a teacher at the now-abandoned village school and the father of Zhao Qiquan, the blood merchant responsible for causing the outbreak. Being too picky or demanding can diminish your romantic prospects. He decides to make amendments to the villagers on behalf of his unrepentant son by inviting all the infected villagers, including his younger son, Zhao Deyi, to live with him at the village school, where they will look after one another. The Village Head's diary was never found. Find and buy your favorite lucky zodiac and protection charms now to enjoy a good year.


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Bespoke Tax Accountants
Specialist tax advice, accountancy and tax returns
info@bespoketax.com
Personal and Family
31 October paper Self-Assessment filing deadline
8th October 2020 By bespoketax
The 2019-20 tax return deadline for submitting your paper Self-Assessment returns is 31 October 2020. Due to the impact of coronavirus, taxpayers were able to delay making their second payment on account for the 2019-20 tax year (due on 31 July 2020) until 31 January 2021.
It has also been announced that most taxpayers will be able to benefit from a separate additional 12-month extension from HMRC on the "Time to Pay" self-service facility for this payment on account and also for other payments due in January 2021 extending the deadline until January 2022.
If you are still submitting paper tax returns, we would recommend that you consider the benefits of submitting the returns electronically. This includes gaining an additional three months (until 31 January 2021) in which to submit your return. You will also receive instant confirmation that a return has been filed and not need to rely on postal service.
Late submission of a Self-Assessment return will become liable to a £100 late filing penalty. The penalty usually applies even if there is no liability or if any tax due is paid by the relevant deadline.
If you received a letter informing you to submit a paper return after 30 July 2020, then you have an extended deadline which runs for three months from the date you received the letter in order to submit a paper return.
23rd October 2019 By bespoketax
The 2018-19 tax return deadline for submitting your paper Self-Assessment returns is 31 October 2019. Late submission of a Self-Assessment return will trigger a £100 late filing penalty. The penalty usually applies even if there is no liability or if any tax due is paid in full by 31 January 2020.
If you are still submitting paper tax returns, we would recommend that you consider the benefits of submitting the returns electronically. This extends the filing deadline by an additional three months (until 31 January 2020). You will also benefit from quicker repayments of any tax refunds you may be due and instant confirmation that a return has been filed.
Daily penalties of £10 per day will take effect if your tax return is still outstanding three months after the filing date up to a maximum of £900. If the return still remains outstanding further higher penalties will be charged from six months and twelve months.
If you received a letter informing you to submit a paper return after 30 July 2019, then you have an extended deadline which runs for three months from the date you received the letter requesting you to submit a paper return.
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Thousands of dog lovers are set to descend on Stafford next weekend, for one last chance to qualify their four legged friends for the world's largest dog show, Crufts, as Manchester Dog Show Society holds its annual championship dog show at the Staffordshire County Showground, Weston Road, Stafford from 16th- 19thJanuary.
The Kennel Club, which licenses the show, made Manchester Championship Dog Show the last show at which dogs can qualify to compete at this year's Crufts, being held at Birmingham's NEC from 6th- 9thMarch 2014, and almost 9,000 dogs from over 150 breeds will be strutting their stuff in Stafford over the weekend.
Dogs have been competing for the past year, at hundreds of championship dog shows held across the country, to qualify for Crufts 2014.
Each day of the show will play host to different breeds of pedigree dog, which are divided into seven groups. On Thursday 16thJanuary, visitors will get to see the Hound and Terrier groups being judged, followed by the Toy and Utility groups on Friday 17th, the Working and Pastoral groups on Saturday 18th, and the Gundog group on Sunday 19th. The seven group winners will then compete for the prestigious Best in Show award in the exciting climax of the show on Sunday. To find out which group your favourite breed is in, please visit www.thekennelclub.org.uk/services/public/breed.
Paul Harding, Secretary of Manchester Dog Show Society, said: "We are very pleased by the Kennel Club's decision to make the show the last qualifying show for Crufts 2014, which has contributed to an increased entry figure this year."
Caroline Kisko, Kennel Club Secretary, added: "Because it is the last chance for Crufts 2014, dog lovers will be travelling to Stafford from all over the country with their dogs, hoping to impress the judges and get their paws on a top prize.
"Local dog lovers of all ages can come along to the show to see their favourite breeds in action, from the firm family favourites such as the Labrador, Pug and Staffordshire Bull Terrier, to the rarer native British breeds such as the Otterhound, Miniature Bull Terrier and Curly Coated Retriever. Visitors will also be able to talk to expert owners about caring for healthy, happy dogs and find out more about the most popular canine activity in the country - dog showing."
Entry to the show and car parking are free.
To find out more about dog showing, and for a list of championship dog shows for 2014, visit www.thekennelclub.org.uk/dogshowing.


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Research History
New research could identify those most susceptible to tuberculosis (TB)
A team of scientists led by the University of Aberdeen has identified a key receptor involved in the control of tuberculosis (TB) which could help to identify those most likely to get the infection.
University wins funding to help Tanzania develop oil and gas expertise
The University of Aberdeen and the University of Dar es Salaam (UDSM) have been awarded two million euros in European Union funding to help develop higher education in Tanzania and create a sustainable oil and gas sector in the East African country.
Earthquake prediction: science or fiction?
An Aberdeen Professor has been 'shaking-up' popular beliefs about earthquakes and uncovering cracks in current methods of predicting when they may happen.
Student scoops top prize at Westminster research exhibition
A University of Aberdeen student has won the top award at the annual Posters in Parliament exhibition, which features the very best in undergraduate research from across the UK.
Volunteers required for plant protein study
Researchers from the University of Aberdeen Rowett Institute of Nutrition and Health are examining whether augmenting our diets with plant protein could lower the risk of cardiovascular disease (CVD) and improve gut health.
Baby, were you born this way? Event to explore if adult ill health is already determined at birth
Two academics from the University of Aberdeen have been working together to investigate whether illnesses we experience as adults may have been pre-determined from the time we are born. Dr Steve Turner, Senior Clinical Lecturer, and Dr Sohinee Bhattacharya, Lecturer in Obstetric Epidemiology, utilised data gathered from every expectant mother that...
Major study led by autistic scientist challenges long-held preconceptions about the condition
A scientist with autism has used his own experiences to aid the completion of a study which challenges some of the most commonly-held beliefs about the condition.
DVD reduces MRI Scan patient anxiety
A study has shown that a DVD designed to help people prepare for a Magnetic Resonance Imaging (MRI) scan, including guidance on how to relax, led to more successful scans.
PhD scholarship opportunities at University of Aberdeen
High-achieving students looking to begin a PhD could benefit from a £1 million scholarship fund set up to honour the University of Aberdeen's founder.
Next generation of dementia scientists to focus on lifestyle factors
Scottish scientists investigating the causes of dementia will study how lifestyle factors impact on memory and brain degeneration as seen in dementia.


Notting Hill is a charming West London location. Full to brim with independent eateries, quirky little gastro pubs and attracting a stylish crowd, Notting Hill is overflowing with character - you stand a pretty good chance then, of stumbling upon one of the best restaurants in London. Whatever it is that you fancy, we have got it covered in our handy 'lil list of the top restaurants in Notting Hill; each with their own charm, and all boasting a unique menu of all sorts of tasty goodness from across the world.
The Little Yellow Door is the all-new home of The Flatmates, as they're returning to Notting Hill. Expect even more house parties, quirky supper clubs and boozy brunches from the kooky gang, who are sure to make you feel right at home.
The Commander Porterhouse is not shy in its grandeur, but manages to retain a warm and welcoming atmosphere to consistently attract a cool and stylish West London crowd. This Notting Hill restaurant prides itself on its commitment to serving great homemade dishes throughout the day until late, creating delicious dishes using on the freshest, local produce.
Nestled in the heart of Notting Hill, this Ladbroke Road local is all about Asian dishes and warming interiors. An ideal choice from winter through to summer, you'll find a cosy terrace complete with creative cocktails and all kinds of seafood.
One of the best restaurants in Notting Hill, Andina combine delicious Peruvian cuisine with bright open interiors to create a charming spots for lunches, drinks or dinnertime feasting.
Spread across two tiers, Pizza East Portobello is one of the most popular, and undoubtedly one of the best restaurants in Notting Hill. Pizza East Portobello offers a cool, and relaxed atmosphere, attracting a stylish crowd on the hunt for good pizza, bespoke cocktails and all round good times. Look forward to 10 inch pizzas made from the exclusive house recipe, with a fresh tomato base and all sorts of tasty toppings.
Only part of the Electric House experience, Electric Diner is only one puzzle piece that makes the up whole. Members of Electric House can enjoy the drinking library, bar, restaurant, private cinema and smoking terrace, alongside other private areas that can be enjoyed. Electric Diner serves up a spectacular array of French and American dishes in a vintage style setting.
Inspired by the street vendors and local Taquerias found throughout Mexico and Southern California, Crazy Homies serves up a cool selection of authentic recipes. Expect punchy, contrasting recipes and wholesome portions, alongside a selection of smokey and frozen Margaritas to keep thirst at bay. Boasting hip décor, a fun time party atmosphere and attracting a stylish West London Crowd, Crazy Homies is a cool alternative on the London bar and restaurant scene, and is a restaurant in Notting Hill that will guarantee a truly awesome night.


brother fred, am still feeling the peace and strength of the Holy Spirit as these days speed by to our gathering to our Lord and Saviour Jesus Christ! like you said, 'something big is about to happen'!!! praise the Lord!
Amen sister Karil and also I find people I would like to see get saved before the catching away seem to be like in the days of Noah they are in more of a mocking state towards God and his word (Matthew 24:37-39), life goes on, for them it's just another day, everything's fine, things will get better, they are blind they don't see that time is running out as we do! Praise the Lord! and God Bless!


The single, open plan living space where you enter is situated on the upper ground floor and contains the cooking, eating and relaxing areas, as well as a study. A timber deck maximises the expansive and uplifting views.
Four bedrooms and a winter snug are contained within the lower ground floor. Natural and sustainable materials are used throughout, including slate, stone, bath stone render and raw oak cladding. Warmcel recycled newspaper was used to insulate the roofs and walls.


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package com.linkedin.pinot.serde;

import javax.annotation.concurrent.NotThreadSafe;
import org.apache.thrift.TBase;
import org.apache.thrift.TDeserializer;
import org.apache.thrift.TException;
import org.apache.thrift.TSerializer;
import org.apache.thrift.protocol.TProtocolFactory;
import org.slf4j.Logger;
import org.slf4j.LoggerFactory;

/**
 * Thrift based serialization-deserialization.
 *
 * Note: We did not make this a serialization protocol (thrift, kryo, protobuf...) agnostic  interface
 * as the underlying requests/response is itself specific to protocol (thrift vs protobuf). It does not
 * make sense to encapsulate the serialization logic from it. In future if you want to move away from thrift,
 * you would have to regenerate (or redefine) request/response classes anyways and implement the SerDe for it.
 *
 * Please note the implementation is not thread-safe as underlying thrift serialization is not threadsafe.
 *
 */
@NotThreadSafe
public class SerDe {
  protected static final Logger LOGGER = LoggerFactory.getLogger(SerDe.class);

  private final TSerializer _serializer;
  private final TDeserializer _deserializer;

  public SerDe(TProtocolFactory factory) {
    _serializer = new TSerializer(factory);
    _deserializer = new TDeserializer(factory);
  }

  public byte[] serialize(@SuppressWarnings("rawtypes") TBase obj) {
    try {
      return _serializer.serialize(obj);
    } catch (TException e) {
      LOGGER.error("Unable to serialize object :" + obj, e);
      return null;
    }
  }

  public boolean deserialize(@SuppressWarnings("rawtypes") TBase obj, byte[] payload) {
    try {
      _deserializer.deserialize(obj, payload);
    } catch (TException e) {
      LOGGER.error("Unable to deserialize to object :" + obj, e);
      return false;
    }
    return true;
  }
}

redpajama_set_name: RedPajamaGithub


Hello everyone! How are you all doing!? I have another Christmas card to share today, this one with my rubber image, "Penguin and Reindeer Friends" from Whimsy Stamps. I coloured it with a combination of Copics and prismacolour pencils on the image, and just Copics on the background/ground/trees.
The two designer papers are from two of my sets at Whimsy: Christmas Red Gold and Green, and I Dream In Christmas.
Also used on this card is some gorgeous and fun to use Chipboard by Make It Crafty, and also available at Whimsy Stamps!
I wish you did videos. I would love to watch you color. Beautiful card.
ALL of your penguins are completely adorable, and the cute reindeer is just an added treat on this card, Crissy. Truly lovely for the winter/holiday season.


Name a light for someone special on London's Oxford Street and help keep children safe. Each £5 donation will help keep children safe and free to dream at Christmas.
As well as being an approved VOSA Testing Station we are very proud on what we offer on our service packages from a quick check over before you go on a long journey to a full service including cam belt change. We are confident that all of our service deals will be more comprehensive than that you will receive at a main dealer.
Goodbye Shell V-Power Nitro+, Hello New Shell V-Power.
Copyright 2019 © Laurels Service Station. All Rights Reserved.


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Two Nicholsons and a Movie
Movies are a hobby, right?
At The Cinema
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This movie still packs a punch with effects that don't look dated. Strong story and script with phenomenal fight choreography. Love the look and feel of this one. 10/10.
Firstly, this movie still looks great. Amazingly good work, when CGI is needed, and a reliance on the practical when possible, meant that this movie does not look like it came from previous century. The story is strong after many re-watches, and a basic understanding of philosophy makes this so much more than just a fun action film. Film-making done right, from start to finish. 10/10.
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We like movies! We want to tell you what we think about the movies we've seen. This also helps us remember what we've seen :D	View all posts by Two Nicholsons
2021, At the Couch, Movie Review


I was initially drawn in by the opportunity to attend a highly ranked executive program on a schedule that fit my needs. The ability to focus in sustainability cemented my decision as it would not only draw other sustainability professionals, but a portion of the coursework would be directly related to my interests.
Federal buildings are required by executive order to continue improving their energy efficiency. Many have already "picked the low-hanging fruit", so they must now look to state-of-the-art technologies for further improvements. However, there are significant challenges to actually deploying these technologies in the field. Individual building managers are generally unwilling to take on the risk associated with new technologies, even when they've been vetted in an independent study. If they are willing to take the risk, procurement can still be difficult due to strict federal acquisition regulations and funding constraints (e.g., "color of money").
I'm a nerd. I play video games and can code in Fortran (plus some more useful languages). As a result, I'm often reluctant IT support for my family and coworkers.


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What Is Cancer Immunotherapy?
Cancer immunotherapy is rapidly becoming a major new weapon in the fight against this deadly disease. Here is a brief primer on this powerful new technology, as well as a look at where it's likely headed moving forward.
George Budwell
(TMFGBudwell)
George Budwell has been writing about healthcare and biotechnology companies at the Motley Fool since 2013. His primary interests are novel small molecule drugs, next generation vaccines, and cell therapies.
Cancer immunotherapy, or "immuno-oncology", aims to enable patient's immune system to recognize and subsequently destroy malignancies. Although immuno-oncology as a field has been around for decades, it is only now beginning to be viewed as an important new weapon in the fight against cancer.
Source: Wikimedia
In 2013, for instance, immunotherapy was named the "breakthrough of the year" by Science magazine after a handful of monoclonal antibodies targeting so-called "immune checkpoints" were shown to dramatically reduce the size of tumors and extend patients' lives in a variety of cancers.
The basic idea behind this branch of immuno-oncology known broadly as checkpoint inhibitors is to suppress a tumor's ability to evade detection by the immune system, allowing the body to mount a potent immune response. Checkpoint inhibitors, in a nutshell, release the brakes on the immune system, which is a radically different approach from other immunotherapies, such as vaccines, that seek to amp up the immune response.
Source: Merck
The immense power of checkpoint inhibitors as anti-tumor agents is being proven in the clinic by Bristol-Myers Squibb's (NYSE:BMY) programmed cell death, or PD-1, inhibitor nivolumab (Opdivo) and Merck's (NYSE:MRK) similar drug, pembrolizumab (Keytruda). In the second line setting for metastatic melanoma, for example, these drugs led to unprecedented levels of complete remissions and durable responses. As a result, the U.S. Food and Drug Administration approved both of these novel drugs on an accelerated basis for advanced melanoma in late 2014. And these game-changing checkpoint inhibitors are now barreling toward the non-small cell lung cancer market, and are in pivotal trials for dozens of additional hard-to-treat tumor types such as bladder, liver, head, and neck cancer.
Another rapidly-emerging branch of the immuno-oncology tree is an area known as chimeric antigen receptor (CAR) transduced T cells. CAR-Ts are made by first extracting a patient's T cells from the blood and then using a viral vector to get the cells to express a receptor associated with a specific cancer antigen. The modified cells are then infused back into the patient, where they are then able to recognize and eliminate the cancerous cells of interest.
Source: Bellicum
While this approach to fighting cancer sounds great, the clinical results have been a mixed bag so far. The first-generation therapies proved to be highly efficacious -- especially in blood-based disorders such as B-lymphoid malignancies -- but they came with an unacceptable safety profile, even killing some patients.
Companies like Bellicum Pharmaceuticals (NASDAQ:BLCM), Kite Pharma (NASDAQ:KITE), Juno Therapeutics (NASDAQ:JUNO), Novartis (NYSE:NVS), and Ziopharma (NASDAQ:ZIOP) are all developing a second-generation of CAR-Ts with the stated goals of improving their safety profile and making them more potent against a wider range of cancers. And if all goes according to plan, the first CAR-T therapy could be on the market as soon as 2017.
How much do cancer immunotherapies cost?
Like most new cancer drugs, immunotherapies are mind-blowingly expensive. The annual cost of Keytruda and Opdivo, for example, are each estimated to be in neighborhood of $150,000. Making matters worse, Opdivo is currently indicated as a co-treatment for advanced melanoma with Yervoy, putting the total annual price in the area of $370,000. The prostate cancer immunotherapy Provenge is also incredibly costly, with a price tag of $175,000 for a typical three-month course of treatment. While the projected costs of the forthcoming CAR-T therapies haven't been announced yet, they will probably all top $100,000 a year based on the current pricing points for immunotherapies in general.
Where is cancer immunotherapy headed?
The future of immunotherapy is undoubtedly going to be combination treatments. A key lesson from the early success of Opdivo and Keytruda is that they tend to work really well in patients that express a lot of a transmembrane protein known as PD-L1, or programmed death ligand 1. Given that this encompasses only about 20% to 40% of patients depending on the tumor type, the next step is to explore the use of other monoclonal antibodies with different therapeutic targets, in conjunction with PD-L1 inhibitors.
Big pharma has also become keenly interested in exploring the use of various immunotherapies with more traditional treatments like radiation and all-oral therapies. Indeed, these are primary goals in the emerging clinical programs of immunotherapy leaders such as AstraZeneca (NYSE:AZN), Pfizer (NYSE:PFE), and Roche (OTC:RHHBY). And that's why some industry experts believe that immuno-therapies could gobble up a noteworthy 60% of the entire cancer drug market within the next decade, making them a potentially disruptive new technology in the battle against cancer.
BMY
NYSE:BMY
Kite Pharma
NASDAQ:KITE
NYSE:NVS
RHHBY
Roche Holding Ltd. (ADR)
OTC:RHHBY
ZIOP
ZIOPHARM Oncology
NASDAQ:ZIOP
Juno Therapeutics
NASDAQ:JUNO
NYSE:PFE
BLCM
Bellicum Pharmaceuticals
NASDAQ:BLCM
NYSE:AZN
NYSE:MRK
What Is Cancer Immunotherapy? @themotleyfool #stocks $BMY $KITE $NVS $RHHBY $ZIOP $JUNO $PFE $BLCM $AZN $MRK Next Article


balavardhana, khilAI, khilAIpilAI, nyUTrIshana, posa, posha, poshaNa, pariposhaNa, prANachaya, pushTi, shaktivardhana, shaktivriddhi, sinchana, samposha, samposhaNa, sanvardhana, sudriDh.ana, suposhaNa.
chikitsA, AhAra, pAlanaposhaNa, poshavya, paushTika, samriddhana, svasthatA, viTAmina.
the organic process of nourishing or being nourished - the processes by which an organism assimilates food and uses it for growth and maintenance.
alimentation, invigoration, nourishment, nurturing, nutriment, nutrition, strengthening, sustenance.
enrichment, healthiness, meal, medication, nutrient, nutritious, upbringing, vitamin.
खिलाई, खिलाई पिलाई, न्यूट्रीशन, परिपोषण, पुष्टि, पोष, पोषण, पोस, प्राणचय, बलवर्धन, शक्तिवर्धन, शक्तिवृद्धि, संपोष, संपोषण, संवर्धन, सिंचन, सुदृढ़न, सुपोषण.
आहार, चिकित्सा, पालनपोषण, पोषव्य, पौष्टिक, विटामिन, समृद्धन, स्वस्थता.
pushTi, shaktivriddhi, khilAI, khilAIpilAI, poshaNa, pariposhaNa, suposhaNa, samposhaNa, sinchana, sudriDh.ana, sanvardhana, shaktivardhana, balavardhana, nyUTrIshana, prANachaya, posha, samposha, posa.
पुष्टि, शक्तिवृद्धि, खिलाई, खिलाई पिलाई, पोषण, परिपोषण, सुपोषण, संपोषण, सिंचन, सुदृढ़न, संवर्धन, शक्तिवर्धन, बलवर्धन, न्यूट्रीशन, प्राणचय, पोष, संपोष, पोस.


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Now reading: Kopparberg releases canned pink gin and lemonade RTD
Kopparberg releases canned pink gin and lemonade RTD
Swedish cider producer Kopparberg has moved into the ready-to-drink (RTD) market with the launch of a canned strawberry and lime-flavoured gin and lemonade.
The launch of the new RTD comes just a month after the Swedish producer entered the spirits category with a strawberry and lime-flavoured gin. This was followed by a limited edition mixed fruit-flavoured gin, unveiled last week. Packaged in a 250ml can, Kopparberg Premium Gin & Lemonade has an abv of 5% and contains 125 calories per serve. The new offering is targeted at summer outdoor occasions and parties this year. The spirit-based RTD was created due to the fact that "impulse occasions continue to be a strong driver of growth" for the cider brand. Rob Salvesen, head of marketing, said: "We wanted to continue the momentum and excitement surrounding the launch of Kopparberg Premium Gin and launch RTDs into the UK market ahead of summer. "The perfect serve of Kopparberg Premium Gin & Lemonade was designed to enhance the natural flavours of the gin and offer a taste profile sweet enough for a long, hot summer. "It's the perfect drink to enjoy with friends and we're very excited to offer Kopparberg fans another addition to the Kopparberg family." Kopparberg Premium Gin & Lemonade is available in single 250ml cans (RRP £1.95) and 4x250ml cans priced at £6. It is available to buy from UK supermarket Asda today (4 June).


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Thinly sliced: Department of Agriculture hamstrings crucial honeybee research
Jason Jacobs / Flickr
by New Food Economy
This is the web version of a list we publish twice-weekly in our newsletter. It comprises the most noteworthy food stories of the moment, selected by our editors. Get it first here.
Hold your cell-cultured horses. Cell-cultured meat. Even though you're likely years away from eating it, scientists are already talking about how to improve it. Natalie Rubio, a doctoral student who's being funded to develop the technology at Tufts University, writes in The Conversation about culturing meat that's more like steak than hamburger. As we've reported, scientists are already trying to fill empty plant leaves with animal cells to accomplish something similar.
Best in show. The best ginseng in the world is grown in Wisconsin. At least, that's according to Wisconsin Public Radio, which we won't accuse of home-state bias because their reporting is always spot-on! The station finds that President Trump's trade war is threatening the growers, because their biggest customer, China, is adding as much as 40 percent to the price of the root. That's not to say it won't keep buying ginseng from America's Dairyland—it's the best in the world!—but it's the farmers, and not consumers, who are expected to absorb those costs.
Why did the chicken cross the freeway? Highways can have detrimental impacts on wild animals—they literally split apart natural ecosystems. But overpasses and underpasses connected to vegetated medians can help feed wild animals, according to a new study out of the University of Alberta. Over the course of three years, researchers observed that animals—including squirrels, chipmunks, and minks—rarely used wildlife passages to completely cross roads. Rather, these species mainly used the pathways to access freeway medians, where they then foraged for food. Dig in!
Blue Bell blues. We've all been there: Passing through the ice cream aisle, steadfast in our determination to abstain, yet still tempted. One lick couldn't hurt, could it? That's the premise behind a viral video that surfaced in late June on Twitter, in which a woman licks a quart of Blue Bell ice cream and returns it to the freezer. The video sparked a lot of internet outrage and spawned a few copycats, The Washington Post reports. Police have since arrested one of them.
Another blow for bees. USDA has announced it will no longer compile its annual Honeybee Colonies Report, a comprehensive look at the broad landscape of honeybee health. As CNN reports, this is just the latest federal ag research project to get the axe, though this one could bear dire consequences. As global honeybee populations continue to drop off, putting the stability of our food systems at risk, losing this dataset could further hamper research that's critical to slowing the decline.
Newsthinly sliced
New Food Economy
By New Food Economy's editors.
Thinly sliced: Is wild American ginseng headed to extinction?
Thinly sliced: Bayer's market value may have plummeted, but its profits are still piling up
Thinly sliced: Wisconsin residents take on the state's $88 billion-dollar agriculture industry


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In Ohio, running a red light/stop sign violates ORC 4511.12 which is a minor misdemeanor. If this is your first of these, there is no jail time possibile. The only penalty is a fine, which can be up to $150. There are no points assessed for this offense.
I a to. trial in march. Going to trial in march. New york.
Im looking to file a 440.10 motion to vacate judgement. NY.


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Description: Piedmont Recovery is a business categorized under others miscellaneous retail, which is part of the larger category business services. Piedmont Recovery is located at the address 4749 Gum Branch Road in Jacksonville, North Carolina 28540-9122. You can contact by phone (910)455-9426.
Location & access map for "Piedmont Recovery"


The Bennington Township Special Board Meeting was called to order by Supervisor Lee Ash on October 10, 2017, 10:30am, at the Township Hall.
Garber moved to submit the L-4029, 2017 Tax Rate Request, with the millage request rate of .9936 for Operating, 1.0 for fire, and .1763 for SATA to be levied December 1. Seconded by Zdunic. All board members in favor. Motion carried.
Zdunic moved to adjourn. Seconded by L. Ash. Motion carried.


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Q: Can someone give me a good reason for why assert in php behaves the way it does? PHP's assert statement doesn't behave like most other languages.
assert('return false'); actually evaluates the string and then asserts its result (false).
Instead of comparing the parameter to true, it goes through the extra step of examining the argument, and if it's a string evaluating it, then performing the comparison.
Very strange indeed.
My problem is not in understanding the behaviour, my problem is coming up with a valid reason for this behaviour, esp. since you now have to do the extra mental work of thinking... "does that evaluate to a string?".

A:
The advantages of a string assertion are less overhead when assertion checking is off and messages containing the assertion expression when an assertion fails. This means that if you pass a boolean condition as assertion this condition will not show up as parameter to the assertion function which you may have defined with the assert_options() function, the condition is converted to a string before calling that handler function, and the boolean FALSE is converted as the empty string.

from http://www.php.net/manual/en/function.assert.php

A: I would guess it simply is so they didn't need to special case a particular part of the language. I believe that in PHP if you treat a string like an expression is it evaluated automatically. This way you can do things like just pass the name of a function and try to "call" it and it works (function pointers without the pointers :-P).
EDIT: see Jakob's answer for a relevant quote from the PHP docs about assert as well.

redpajama_set_name: RedPajamaStackExchange


Mr. Ghossoub is the Owner and Chairman of G&Co., a premium real estate developing company. Prior to that, Mr Ghossoub's career in marketing communications spans twenty-five years, most of which he has spent in the United Arab Emirates. His success at the helm of the Middle-Eastern affiliate of one of the world's largest advertising groups, Young and Rubicam, are among the credentials which served him well in his selection as IAA World President. Joseph Ghossoub is Chief Executive Officer of Menacom, parent company of Team/Young & Rubicam, Intermarkets Advertising, ASDA'A Public Relations, mediaedge and Wunderman. One of the Middle East communications industry's most prominent spokesperson, he has been involved in managing regional and global agencies for over two decades. Joseph served as Vice President of the International Advertising Association's (IAA) UAE Chapter and was elected President in 1995. In 1996 he joined the IAA World Board and the IAA World Council. During his tenure, he carried out innovations leading to his election as International Vice President and Area Director of the IAA MENA, a post held since 2000. He played a major role in winning the bid to host the IAA's 40th World Congress in Dubai in 2006.


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Nothing pleases me more than sitting down with 10 jars of peanut butter and a spoon to taste and review each one. Sometimes I think that's what heaven would be like, except you wouldn't get full and the jars wouldn't run out. But my spiritual beliefs in peanut butter have yet to enlighten me as to why all the different brands, varieties and flavors of peanut butter that exist in America have yet to spread to the rest of the world. In terms of peanut butter technology, the US is light years ahead. No complaints here except that I'm unable to leave the country for extended periods of time. Now for this round of reviews, I go over some crucial store brands you may have missed as well as some interesting flavored peanut butter from upstate New York.
My new favorite grocery store, Wegman's, makes some fantastic natural peanut butter. This variety is perfectly ground to a coarse texture that is rich and thick. It comes unsalted, but that's easily solved by adding around 1.5t of kosher salt per jar. Running at a reasonable price of $2.99 per jar (although nearly twice the price of my current favorite, 365 creamy) this natural peanut butter is a must try! I kind of like the fact that it comes unsalted because I can control the level of salt. And unsalted, it's perfect to use for Peanut Butter Banana Pudding or any other dessert.
Similar to the creamy, this crunchy peanut butter is fantastic. The chunks are very crunchy and the peanut butter in between is coarsely ground, thick and delicious. Once again, if you prefer your peanut butter salty like I do be sure to add 1.5t of kosher salt per jar. I tend to savor this one for special occasions, such as a perfectly ripe banana begging to be loaded with peanut butter or to put on a warm Triple Threat Scone.
Saratoga is a brand I have not heard of, but 2 of my Aunts went to a farmer's market and found a variety of offerings from this company. The texture of this peanut butter is very nice, thick and creamy with tiny chunks spread throughout due to the nature of a coarse grind. When you open it up, the maple smell is overwhelming so I expected a strong tasting and overly sweet peanut butter. I was right in only one aspect, the maple flavor was very powerful but there was only a hint of sweetness. I like the low level of sweetness but they added a bit too much maple flavor (maple extract perhaps?) without the sweetness to back it up. An interesting idea, but either a reduction in maple flavor or increase in sweetness is needed. I tried it on a Colossal Pancake topped with maple syrup but that overwhelmingly maple flavor still came through. Maybe it would work better in a loaf of Dark Chocolate Peanut Butter Banana Bread.
Despite my lack of enthusiasm for Saratoga's maple offering, this flavor is much more interesting. This is a banana and raisin flavored peanut butter. The raisins are finely chopped and therefore are more evenly spread throughout the mixture. In addition, there is some kind of banana flavor or essence added to the peanut butter, similar to the maple flavor, except not nearly as strong. Just the right amount of sweetness brings this flavor to life. The only downside is that if you pair it with anything, even a banana, the delicate flavors of the banana and raisins are almost unnoticeable. Now this flavor works well on a Colossal Pancake, but don't use too much maple syrup on top – a sprinkle of sugar works better.
Here's a unique offering from Trader Joe's. There is a great flavor with crunchy chunks. It's salted nicely but could use a pinch more in my opinion. The addition of the flaxseed is a tasty and healthy addition but confusing at first. Flaxseed has a natural sweetness which complements the fresh peanut flavor but it adds lots of little crunches on top of the peanut chunks. While I eventually enjoyed the texture, it originally felt like there were little bits of plastic in it. A 12oz jar will cost you $2.99, but it's well worth a try. Don't refrigerate it like they recommend, it becomes too thick and nearly unusable. A glob of this is great for added nutrition in some Peanut Butter Cereal.
Not enough peanut butter for you? Then check out all of my Peanut Butter Reviews.
So, did I sell peanut butter to your aunts? Haha, I definitely remember two women buying peanut butter for their nephew in those flavors… what Farmers' Market did they go to?
Thank you for the reviews! The maple has the strong flavor+less sweetness because we try to keep everything as healthy and low in sugar as possible. I'm glad you enjoyed the monkey boy! Try it on a grilled peanut butter sandwich with mashed banana or honey if you need something sweet in there. It really showcases the banana/peanut/raisin flavor!
I have a suspicion that you would enjoy the dark chocolate (Chillin') and white chocolate (Blizzard) Saratoga peanut butters. They're really delicious!
It's very possible! They were probably at a Farmer's Market somewhere in Westchester?
I like the health aspect of the flavors, having very little added sugar, but I think the maple flavor was just too strong, it reminded me a bit of the lingering flavor when you try to drink water out of an empty Gatorade bottle. But yes, Monkey Boy is quite tasty and just sweet enough! I think the key there is that the banana flavor isn't overwhelming but just right.
Those chocolate peanut butters sound great, especially since it's low in sugar. Most chocolate peanut butter has a good amount of sugar that often makes it too sweet.
I am on vacation in Hungary right now and one of the first things I noticed when I got here was that they don't eat PB! I was shocked. So weird.
Haha, well I think it's difficult to find peanut butter anywhere outside the US! Poor you though, you should have brought a jar!
Not so, your neighbours to the North are also of the peanut-butter loving variety, we just have fewer flavours up here, since our food regulations are a bit more stringent than yours.
BTW, 365 is actually produced in Canada!
My mistake, I misspoke! Canada does have a decent array of peanut butter from what I've heard. Ok, so outside of North America it's difficult to find peanut butter!
I live in New Zealand and we love peanut butter! We don't have different flavours really though, just crunchy or smooth, salted or unsalted.
Great review- that maple peanut butter has me quite intrigued!!!
Intriguing is the perfect word to describe it. Perhaps I should just add some sugar to it….
Yes, we love the flaxseed one from TJ's. Has a nice bit of crunch. I think you're right though–could use a touch more salt.
The salt brings out the flavor better but I also think it somehow helps the stickyness factor.
It IS sticky, isn't it? But great with jam!
I read about that one, I really want to try it but I can't find that brand anywhere around here.
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Business & Economics - General
The Stolper-Samuelson Theorem
A Golden Jubilee
Edited by Alan V. Deardorff and Robert M. Stern
In celebration of the fiftieth anniversary of the Stolper-Samuelson Theorem, this volume collects in one place the original Stolper-Samuelson articles as well as the most significant later contributions that interpret, extend, and test the basic result. It also includes reflective papers by both Wolfgang F. Stolper and Paul A. Samuelson, an overview of the literature, and an annotated bibliography. Contributors to the volume, either in reprints of their original articles or in new commentary, are Robert E. Baldwin, Sundari R. Baru, Jagdish N. Bhagwati, John S. Chipman, Alan V. Deardorff, Wilfred Ethier, Ronald W. Jones, Murray C. Kemp, Ulrich Kohli, Paul R. Krugman, Edward E. Leamer, Stephen P. Magee, Lloyd A. Metzler, Ronald Rogowski, Paul A. Samuelson, Jose A. Scheinkman, Robert M. Stern, Wolfgang F. Stolper, and Leon Wegge.
Passion and Craft
Applied International Trade Analysis
Dynamics, Economic Growth, and International Trade
Trade Threats, Trade Wars
New Directions in Trade Theory
DOI: 10.3998/mpub.9690073
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