text:
Stockdale Sow 11 is the Most Improved sow for Q2 of 2019
"This is a group that has surpassed my expectations and it's been fun to watch them excel," said sow supervisor, Mark Lee. "There have been many long days leading up to this point, but their hard work is finally starting to pay off. I'm really proud of them."
Health issues, staffing setbacks and an older herd have made for a tough couple of years for Stockdale Sow 11, but it looks like they're finally starting to see the light at the end of the tunnel. The farm was recently named Most Improved Sow Farm for Q2 of 2019.
"For a long time, we were the poster child for what positive filtration can do for a sow farm," said manager Lance Lawrence, in regard to Sow 11 being the first positively filtered sow farm at Iowa Select Farms. "We went from endemic to complete cleanup."
Back in 2017, less than two years after the farm's positive pressure filtration remodel was complete, their pigs/sow/year had jumped from 22.9 to 28.7, total born increased from 13.6 to 15.5 and pre-wean mortality dropped from 17.8% to 14.4%.
When the farm found out at the end of 2017 that they had somehow gotten PRRS, it was a tough pill to swallow for Lance, breeding department head, Camden Bates and farrowing department head, Amanda Johnson.
"You can definitely say it was a big setback," said Amanda, who along with Lance and Camden has seen the farm through the past two years. "Just when we thought we'd never have PRRS again, we got a big reality check."
For the past two years, the farm has focused on biosecurity. They're not just controlling what comes into the farm, but also cleaning the heck out of everything on the inside. They power wash—often—and spend extra time changing gloves, needles and scalpel blades in between every litter of pigs they process. A task that can be done in about 3 seconds, but easily adds 1-2 extra hours to their day.
"Lance, Amanda and Camden are seasoned employees and great leaders for the farm," said Mark. "They know the long-term benefits of what they're doing daily and communicate that to their team. It makes it easier to stay motivated during exhausting days because they've explained how and why it's what's best for the future. Their strong leadership and positive attitude have really made an impact here."
In addition to Lance, Camden and Amanda, the team is comprised of newborn pig specialist, Brandy Perry, breed leads Luis Rodriguez-Coutino and Olga Soto-Rodriguez and animal caretakers Rhea Jayliene Bailey, Jamie Bouzigard, Kylie Chaplin, Nathan Groff, Justin Martin, Cody Reed, Lane Rodamaker and Abigail Whitsell.
"We've grown into a family, even if that means yelling and screaming at each other some days," joked Rhea. "But like a family, we get through it together and always have each other's backs. We're all working towards the same goals."
Those goals, as Rhea alluded to, mostly revolve around getting "clean" again. Although the farm was technically PRRS negative earlier this year, PRRS recirculated in January when a new group of gilts was brought into the farm; however, they're feeling optimistic about the future.
"Luckily this time around hasn't been as bad, but of course our ultimate goal is to get the farm "clean" again and stay that way. But after that, everyone better look out," chuckled Lance. "We're looking good to start getting gilts in soon and getting back towards that number one spot. Don't be surprised if we make appearances in the Top Ten or get Most Improved Sow Farm again. We're just getting started."
Congrats to Lance, Camden, Amanda, Rhea, Jamie, Kylie, Nathan, Justin, Brandy, Cody, Lane, Luis, Olga and Abigail on your Q2 success. We can't wait to see what the rest of the year has in store for you.


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text:
"""
parsedatetime/warns.py

All subclasses inherited from `Warning` class

"""
from __future__ import absolute_import

import warnings

class pdtDeprecationWarning(DeprecationWarning):
    pass

class pdtPendingDeprecationWarning(PendingDeprecationWarning):
    pass

class pdt20DeprecationWarning(pdtPendingDeprecationWarning):
    pass

warnings.simplefilter('default', pdtDeprecationWarning)
warnings.simplefilter('ignore', pdtPendingDeprecationWarning)

redpajama_set_name: RedPajamaGithub


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text:
Breast cancer drug hope for women with Angelina gene
SCIENTISTS have had a major breakthrough in the treatment of early breast cancer for women carrying a BRCA mutation - dubbed the "Angelina Jolie gene".
By Hanna Geissler
09:42, Fri, Jun 4, 2021 | UPDATED: 09:42, Fri, Jun 4, 2021
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Using the drug olaparib after initial treatment and chemotherapy slashed the risk of cancer returning or spreading by 42 percent. The discovery could lead to more women being cured of high-risk breast cancer after early diagnosis. Dr Simon Vincent, director of research, support and influencing at charity Breast Cancer Now, said: "It's extremely exciting.
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"Olaparib must now be promptly submitted for licensing, and then assessed for use on the NHS, so that women with this type of breast cancer start to benefit."
The BRCA genes play a role in repairing DNA damage.
In people who carry mutations, mistakes can build up in the DNA, increasing the risk of a cell becoming cancerous. Actress Angelina underwent a double mastectomy in 2013 after discovering she carried a "faulty" BRCA1 gene.
She later had her ovaries and fallopian tubes removed too.
Olaparib is already used to treat some types of ovarian, fallopian tube or primary peritoneal cancer.
It is a type of drug known as a PARP inhibitor and works by disrupting another DNA repair pathway, causing cancerous cells to die.
The international OlympiA trial, involving almost 2,000 patients, is the first to report on olaparib's ability to stop breast cancer returning when used at an early stage.
After three years, 86 percent of patients treated with the drug were alive and free of invasive breast cancer and second cancers, compared to 77 percent of those who received the usual care and a placebo dose.
Women with Angelina Jolie cancer gene may be able to get special help (Image: Reuters)
Study co-leader Prof Andrew Tutt, of the Institute of Cancer Research and King's College London, said: "Women with early-stage breast cancer who have inherited BRCA1 or BRCA2 mutations are typically diagnosed at a younger age.
"Up to now, there has been no treatment that specifically targets the unique biology of these cancers to reduce the rate of recurrence, beyond initial treatment such as surgery, hormone treatment, radiotherapy and chemotherapy."
He estimated that around 1,000 women could benefit from treatment each year in the UK and hundreds of thousands worldwide.
Prof Paul Workman, chief executive of the institute, said: "This is a major breakthrough."
The findings were presented at the American Society of Clinical Oncology Annual Meeting and published in The New England Journal of Medicine.
Breast Cancer Now's free helpline is 0808 800 6000.
Caroline Wheeldon discovered she carries a BRCA2 mutation after finishing treatment for early breast cancer.
She was diagnosed with stage one triple negative breast cancer in 2019 after pains alerted her to a lump.
Caroline, 40, said: "When I found out I had cancer, my world fell apart.
"I knew straight away that I wanted to have a double mastectomy to reduce my risk of it returning."
Caroline discovered she had the BRCA2 mutation (Image: Getty)
She had a unilateral mastectomy followed by chemotherapy. Due to her age and cancer type, she also underwent genetic testing which revealed she had the BRCA2 mutation, greatly increasing her risk of certain cancers.
She was the first person in her family to have had cancer. But her 70-year-old mother has been discovered to be a carrier of the mutation.
She had a second mastectomy in August last year and had her ovaries and fallopian tubes removed in December 2020. Caroline lives in Barnsley with her husband and two children, Aleisha, 11, and Leo, nine.
She said today's breakthrough gave her hope that better treatments will be available in the future.
She said: "It's so reassuring to know about the possibility of this new treatment.
"I'm really pleased that it might be available by the time my children are grown up, and to help anyone who's diagnosed in the future."
A drug that acts "like a guided missile" to target prostate cancer can extend the lives of men with advanced disease, a study suggests.
The treatment detects the presence of a molecule called prostate-specific membrane antigen (PSMA) on the surface of tumour cells, before delivering a dose of radiation to kill them.
The "seek and destroy" method can shrink tumours while leaving healthy cells unharmed.
An international trial involved 831 patients with advanced prostate cancer, meaning it had spread to other parts of the body.
Those treated with the drug typically survived for 15.3 months compared with 11.3 for those who received standard care alone.
It also extended the average time that passed before patients' cancers got worse from 3.4 months to 8.7 months.
It is estimated that between a third and half of the 10,000 men diagnosed with advanced prostate cancer each year have tumours with high levels of PSMA and could benefit.
Study co-author Professor Johann de Bono, of The Institute of Cancer Research in London, said: "I believe that these results can change the standard of care for some men with advanced prostate cancer."
Dr Matthew Hobbs, at Prostate Cancer UK, said the results were "hugely exciting".
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redpajama_set_name: RedPajamaCommonCrawl