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Globalisation-Induced Tax Changes
by Peter H Egger, Sergey Nigai and Nora M Strecker
Image by Christophe LEUNG CC 2.0 via Flickr https://flic.kr/p/2d4FC7N
Economists have known for a while that increasing globalisation leads to substantial but unequal gains and creates winners and losers.
This rising inequality could be attributed to globalisation's heterogeneous effects on employment, wages, or prices. Trade barriers have been falling in the post-World War II era and have reached an all-time low since the middle of the 1990s. It appears this increasing globalisation may have negative effects on employment in certain sectors, states, and countries. Those in the affected markets may therefore require significant government help in the form of social insurance, unemployment benefits, or training and support to move to new jobs or industries.
Theoretically, inequality created through increasing globalisation could be lessened by local policies aimed at distributing some of the gains of globalisation from the winners to the losers, thereby ensuring that everyone receives a share of the benefits.
However, despite the sizable aggregate gains from trade, there is ongoing backlash against migration and trade, such as the US Trump administration's tariffs and border wall policies, the Yellow Vest movement in France, and support for Brexit in the UK. This suggests that such redistributive mechanisms may not exist or benefits have not been distributed effectively.
A natural and frequently used tool of redistributive policy is a personal income tax system, which can be flat or progressive. Progressivity can be established not only through multi-level marginal tax tables, but also through tax credits or deductions for those at the bottom and middle of the income distribution. The pressure from increasing globalisation should prompt redistribution through income taxation to ensure that enough of the associated benefits are shared with the earners of lower incomes.
However, the tax burden has become higher for middle-income workers…
Our new study, published in the American Economic Review, shows that globalisation has had the opposite effect on income tax systems since the middle of the 1990s. A drastically higher relative tax burden has been set for middle- and upper-middle-income workers than for those in the top 5% of the income distribution.
Figure 1: Average Corporate and Income Tax Rates
Figure 1 depicts the development of the average corporate and labor income tax rates in the 65 largest economies between 1980 and 2007. The average corporate tax rate (red line) has been steadily declining, illustrating "the race to the bottom" – the negative effect of countries' competition to attract and retain firms on corporate tax rates across all locations.
In addition, Figure 1 also indicates that the top 1% of income earners may have experienced a similar decline since the 1980s. This trend may be further aggravated by the fact that a significant part of these workers' incomes stems from non-labor income and may be subject to even lower taxes. Yet, at the same time, the average tax rate of the median worker has steadily increased. Therefore, why do workers in the middle of the income distribution face such different tax results compared to both firms and the rich?
Globalisation itself may be the answer
Reduced barriers to trade and migration have allowed firms and high-income earners to be very mobile. This naturally limits governments' ability to tax these bases before the bases choose to relocate in order to lower their taxes. As a result, lower effective tax rates become an important factor in attracting foreign firms and highly skilled workers. Therefore, in an increasingly globalised world, redistribution through taxation is rendered much less feasible by the agility of firms and high-skilled (high-income) workers.
In response, governments around the world have begun to increasingly rely on immobile workers in order to stabilise their tax base. Typically, this immobility is a characteristic of those around the low to middle section of the income distribution. This is mainly attributed to the fact that their skills may not be easily transferred across borders or because a lack of resources may preclude them from relocating.
We estimate that between 1994 and 2007 the top 1% of income recipients in the average OECD country saw a reduction in their relative income tax of 0.59 to 1.45 percentage points. By contrast, the tax burden of the median earner has increased by 0.03 to 0.05 percentage points. These globalisation-induced changes in the income tax burden have exacerbated rather than mitigated net income inequality. This trend is likely to continue as the mobility of large companies and high-income workers continues to rise.
A supranational tax?
60% of respondents to a 2014 Pew survey felt that growing inequality was a major challenge and progressive taxation could be one of the ways to tackle this inequality.
However, increasing income tax progressivity may not be as simple as adding more deductions or tax credits or increasing the top marginal tax rates in a globalised world. The high mobility potential of high-income individuals (and firms) limits the ability of governments to tax them; therefore, as long as countries continue to aim to attract and retain high-skilled workers (and the firms that employ them), reducing inequality unilaterally will be challenging.
Another approach could be the multilateral harmonisation and coordination of international labour income tax policy. This proposal arises from our paper's case study of the U.S. multi-tiered tax system, which uses cross-state migration in lieu of cross-border globalisation, and relative tax burdens in both the sub-national and total (national + sub-national) tax layers.
While the reduction in relative tax burden for those at the top of the income distribution prevails, the overall effect is diminished when the federal and state levels are considered together. A supranational tax layer, or at least supranational coordination, might curb the globalisation-induced changes in relative tax burdens across the income distribution.
Although multilateral tax coordination and harmonisation has been on the agenda for a while, there is little discussion about international coordination on personal income tax rates. It may be worthwhile to examine the costs and benefits of such coordination, especially given the growing mobility and increasing dissatisfaction of the public with inequality.
Egger, Peter, Nigai, Sergey & Strecker, Nora,	(2019), Globalisation-Induced Tax Changes, Austaxpolicy: Tax and Transfer Policy Blog, 13 May 2019, Available from: https://www.austaxpolicy.com/globalisation-induced-tax-changes/
Income Tax, Inequality, International taxation
Peter H Egger
Peter H. Egger has been a Professor of Applied Economics at KOF, the Swiss Institute for Business Cycle Research in the Department of Management, Technology and Economics at ETH Zurich since 2009. His research focus is on applied and theoretical panel econometrics, applied and theoretical international and regional economics, industrial organization and multinational firms.
See all articles by Peter H Egger
Sergey Nigai
Sergey Nigai is an Assistant Professor at the University of Colorado Boulder. His research interests focus on the effects of international trade and globalization on workers, consumers, and firms.
See all articles by Sergey Nigai
Nora M Strecker
Nora M. Strecker is a post-doctoral researcher at ETH Zurich. Her research interests focus on public finance, taxation, and international economics.
See all articles by Nora M Strecker


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Q: How to connect firebase in android studio 3.0 and store the data in real time database by press button I'm trying to learn about firebase in android so how can I connect the firebase in android latest version 3.0 and store the data in real time database in my firebase project can anyone help me ....

A: You will be provided with plugins when you create a new project in firebase. You have to paste it in Android studio inside gradle file.
For full reference check this link,
https://www.youtube.com/watch?v=YVu_xSzn2u0&list=PLGCjwl1RrtcTXrWuRTa59RyRmQ4OedWrt&index=2
Youtube Channel - TVAC might help you out

redpajama_set_name: RedPajamaStackExchange


text:
At Least 20% of Pakistan is Underwater (Video)
Brian Merchant bcmerchant
Photo: DVIDSHUB, Flickr, CC BY-SA
After weeks of persistent flooding, the UN now estimates that at least a full one-fifth of Pakistan -- a nation of 170 million people -- is underwater. And the New York Times reports that estimate is probably lowballing the full extent of the damage. 1,600 people are believed to have been killed, and 14 million have been either forced out of their homes or been impacted in some way. The tragedy has gotten so out of hand that Obama has tripled the amount of aid initially sent to the region for disaster relief. And with fresh flood warnings for the coming weekend, Pakistanis are bracing for even more calamity.Here's the NY Times on the new flood warnings:
Pakistan issued new flood warnings on Thursday that could last into the weekend as government and relief agencies strained to confront the toll from a growing humanitarian disaster.
The new warnings to several cities in Punjab and Sindh Provinces added to the desperation of many across the country facing a daily struggle for survival as Muslims around the world began to observe the holy month of Ramadan.
And Climate Progress notes that "The fasting month of Ramadan began yesterday in sorrow for 14 million Pakistanis, as one fifth of the nation is underwater from the worst monsoon-related floods in living memory." The floods, which are thought to be the worst in 80 years, are causing concern on every front -- certainly humanitarian, but also national security. The Times explains how the flooding is offering the Taliban an opportunity to win the hearts and minds of the populace by offering relief and aid -- they're also telling Pakistanis to refuse any US aid.
But US aid is certainly coming, and droves of it. Judging by harrowing video evidence like this, it seems the nation can use it:
It's certainly been a miserable summer for Pakistan (perhaps the understatement of the year), first registering the hottest temperature ever recorded in Asia, and then facing record flooding. And what's worse is that these trends are expected to continue in the future: Both phenomenons fit the projections of climate scientists to a T. Here's NASA:
What we can say is that global warming has an effect on the probability and intensity of extreme events. This is true for precipitation as well as temperature, because the amount of water vapor that the air carries is a strong function of temperature. So the frequency of extremely heavy rain and floods increases as global warming increases.
Looking at a nation that's one-fifth underwater from extreme flooding and registering record high temperatures, it's certainly hard to discount the mounting role of climate change in increasing the probability of such events.
For now, however, the attention must be turned on the aid efforts, and restoring Pakistan's infrastructure and treating those impacted by the tragedy.
More on Flooding and Pakistan
Floods , Monsoons, Heat Waves, Drought: Climate Change In Asia Now
Flooding Tops Tsunami (Video News)
Heavy Rain Kills in UK, Pakistan and Bangladesh
After weeks of persistent flooding, the UN now estimates that at least a full one-fifth of Pakistan -- a nation of 170 million people -- is underwater. And the New York Times reports that estimate is probably
New Zealand schools to teach kids about climate change
Iceland marks lost glacier with a plaque
Is shaming people for flying effective?
Lush Cosmetics will shut down for Global Climate Strike

redpajama_set_name: RedPajamaCommonCrawl


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Home » Sports » Melisandre Stays Undefeated, Gourneau, Whitehall Crowned
Melisandre Stays Undefeated, Gourneau, Whitehall Crowned
September 16, 2020 6:49 AM | Sports
By Scott Taylor (@staylorsports)
Trainers' champion Jerry Gourneau
WINNIPEG — On a night when two-year-old Manitoba-bred sensation Melisandre remained undefeated, the final race of the 2020 Assiniboia Downs thoroughbred season came complete with the most fitting of endings.
Jerry Gourneau, the 60-year-old veteran trainer from Turtle Mountain Chippewa Reserve in Belcourt, North Dakota, completed a record-setting season with a victory in the final race of the year at ASD, a $9,000 Claimer. Henry S. Witt Jr.'s Kats Second Silver, ridden by Nirone Austin, gave Gourneau 73 victories on the season, easily the most by a trainer during a 50-day meet.
"Jerry Gourneau concluded what could likely only be called the most dominant training season in the history of Assiniboia Downs," said Downs CEO Darren Dunn. "The skill he brings to the table, the strength of his team at the barn and the sheer volume and talent of the horseflesh he brought to the oval this year were simply overwhelming to the competition.
"It's a very well-deserved title for Team Gourneau."
Gourneau is a veteran at the Downs and one of the finest trainers' in ASD history. In fact, he's been in the horse racing business for almost his entire life. In fact, even while completing his Masters' Degree in Education, even while spending time as a school administrator and even as an administrator for a major National Science Council Grant in the United States, Gourneau has always kept his hand in the racing industry.
However, in 2009 Gourneau left the education profession to take up training on a full-time basis and for a man who has been working in the equine game for more than 40 years, it's never been as much fun as it is right now.
Born and raised on the Turtle Mountain Chippewa Reserve, about 170 miles southwest of the International Peace Garden, Gourneau and his family would drive to Winnipeg to watch the horses run and then drive home on the same night – three hours both ways.
"My dad, Larry Gourneau Sr., got together with my older brothers, Dave and Bill, and they bought one horse," Gourneau explained. "He was named Sima's Award and we bought it from Assiniboia Downs in 1972 or '73. My dad bought it to run on the bush tracks in Pheasanton, Towner and Rugby, N.D. Belcourt didn't even have a track back then.
"The first good horse we ever owned was L.D. Ribot. My dad and my brother Dave purchased that horse here at the Downs for $1,100. He was a stone-cold winner. He'd win $15,000-$20,000 every year. We had him 'till he was 11-years-old. When they bought that horse, I was 13 or 14 and I was working in the barn. Then, at 16, I started at Assiniboia Downs and I did everything."
While going to school, Gourneau soaked up track life. He worked the barns, he groomed, he galloped horses and was even a jockey on the bush tracks. He'd come to Winnipeg after school ended and live in the No. 9 tack room. His first boss at the Downs was an old trainer named Burnell Rhone.
After college, he went on to university to get his Masters' in Education. He worked his way through school by working for the family racing business, Gourneau Brothers Racing, and by hitting big bets at the Downs. In fact, he bet $100 on a horse called Crime Zone and won $2,750. It paid for more than a semester at school.
After graduating from university, he went on to become a schoolteacher and later, a school administrator. Meanwhile he worked summers in the racing game. In 2009, he decided to go into the thoroughbred industry on a full-time basis and he has been a remarkable success. He won the trainers' title in 2018 at ASD and is now a two-time champion.
Gourneau finished the season with 73 wins, after winning three times over the final two nights of racing, and added 49 seconds, 43 thirds and a record-setting $696,915 in earnings in 299 starts this season. No 2 was six-time champion Tom Gardipy Jr. of Beardy's and Okemasis Cree Nation in Duck Lake, Sask., with 38 wins, 35 seconds, 41 thirds and $344,942 in winnings in 240 starts while another former champion (2012), Shelley Brown, finished third with 23 wins, 34 seconds, 36 thirds and $3298,287 in winnings in 176 starts.
Meanwhile, in the jockey race, Antonio Whitehall, Canada's leading jockey who led at ASD all season, was officially crowned the 2020 champion on Tuesday night.
"It's an incredible accomplishment though not that surprising," said Dunn on Tuesday night. "Antonio has a huge work ethic and such a natural talent in the saddle. He deserves this milestone as he arrived in early March laser-focused on regaining his leading rider title from 2018."
Whitehall, who won the 2018 ASD jockey title with just 41 wins, finished with 74 victories, 54 seconds and 58 third place finishes in a track-leading 299 starts. He earned a whopping $705,869 for his owners. Stanley Chadee Jr., was second with 48 wins, 46 seconds, and 35 thirds in 266 starts and had $536,944 in winnings while Rafael Zenteno Jr., was third with 46 wins, 38 seconds and 31 thirds in 232 starts and had $481,243 in winnings. Kayla Pizarro finished fourth with 30 wins in 204 starts.
In the final stakes race of the season, undefeated two-year-old Melisandre capped a perfect 2020 campaign. Melisandre, the full sister of successful four-year-old Hidden Grace, was bred in Russell, Man., by Cam Ziprick at Ziprick Thoroughbreds and Charles Fouillard. She is owned by Barry Arnason, True North Thoroughbreds and Charles Fouillard, trained by Michael Nault, and ridden by Stanley Chadee Jr.
On Tuesday night, Melisandre led from gate to finish to claim the one-mile, $30,000 Buffalo Stakes. She beat the impressive Prairie Magic by 2 ½ lengths to win her fourth race of the season. This gorgeous chestnut filly, by Going Commando out of High Pioneer, by Pioneering won a Maiden Special Weight on July 22, cruised to victory in the 31st running of the Debutante Stakes on Aug. 4 and won the 32nd running of the $35,000 CTHS Sales Stakes on Aug. 25, by two lengths. She is a very special filly.
It was also a record setting season at the Downs' parimutuel windows in 2020. More people wagered on ASD races via simulcast racing and betting apps than at any time in the track's history and a decision will have to made as to whether or not the Downs will continue racing on Monday, Tuesday and Wednesday nights (popular with on-line punters around the world) as opposed to its usual Wednesday, Friday and Saturday nights.
We'll have more on that later.
← Previous: Manitoba to Retrofit Shipping Containers for PCH Visitation Next: Winnipeg Comiccon Postponed Until 2021 →
Tags: Assiniboia Downs | Winnipeg


: the more comments your adviser adds to first or second draft, the better. Try to distance yourself thesis and dissertations from your usual perspective and look at your work. "Black is white" is simple and catchy. There's another important difference, too. The reader can probably find out via the net or the library.
Indeed, by some law related to Murphy's, you will discover one when you first flip open the bound copy. Mutations in DNA repair genes can lead to microcephaly, demonstrating that maintenance of genomic stability is crucial for proper neurodevelopment and head size. A suggested thesis structure The list of contents and chapter headings below is appropriate for some theses.
The report concerns a problem or series of problems in your area of research and it should describe what was known about it previously, what you did towards solving it, what you think your results mean, and where or how further progress in the field. One important stylistic choice is between the active voice and passive voice. Writing and publishing a scientific paper. I do not think that there is a strong correlation (either way) between length and quality. When writing this section, concentrate at least as much on the physical arguments as on the equations. If you thesis file is not too large, a simple way of making a remote back-up is to send it as an email attachment to a consenting email correspondent; you could also send it to yourself. Where's the circuit diagram? What other methods have been tried to solve it?
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CanTeach contains online resources for educators, including lesson plans, links, discussion lists, and more! Furthermore, ongoing success in science learning requires students to build on the representations and associated practices that they are presumed..


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Fashion style mogul|Colored Ball Gowns!!!
On the wedding day, the bride is supposed to be the center of attention, she is supposed to feel like she is going to a red carpet event, furthermore it is her day. I believe the traditional color of wedding dresses is white but the times have changed and brides have adopted the Islam culture where they wear colored bridal gowns. Wearing a colored bridal gown will literally make you feel like you are attending the Oscars, the SAG, the Grammy's or the Emmy's award shows just like Hollywood royalty. If you are not comfortable wearing it during the wedding then you can wear it during the after party. I know I was supposed to tell you about my proposal story but I decided to save it for the final post….best for last, right?? What do you think about these colored ball gowns!!! Let me know on the comment box below!
Thank you so much Jude, hope to see you on the blog again soon!!
You look stunning, yellow is your color!!!
Awwww1 Yellow it is for sure! Thank you Elena!!
These gowns are beautiful! You remind me of Belle from Beauty and the Beast in the yellow gown — so pretty! Have a nice day.
Hahaha! Somebody else told me the same thing!! Thank you so much Eden!!
Wow! Thesez gowns are plain incredible! The red one is breathtaking! Beautiful Meron!
Hahaha! Thank you so much Jeanne!!!
Thank you for the compliments Lauren and yes, I can't dare sneak in any of these beauties!
Stunning as always Meron! I would never thought of doing a wedding dress in any other color than white but these pics have change my mind.
Hahaha! Changed your mind yet you are the stylist? That is powerful indeed!! Thank you Kathrine!
I love the red one too dear!!
I like the red gown. it is gorgeous. Congratulations on your engagement.
Thank you so much Wendee, the red gown is truly a beauty!!
Thank you for stopping by Remi!!
These gowns are so pretty, and you look amazing, as always!
Awwwww! Thank you Vanessa!! You are too kind!
I love the coloured gowns! These all look amazing on you. I think any dress would look amazing on you. You are going to make a gorgeous bride, and I can't wait to hear your proposal story!
Thank you so much Lili!! You always know what to say to me. Friday is the day of the proposal story!!
Girl… Yellow is for your skin!!! You look amazing in yellow!
Tell me about it!! Thank you so much Rshan!!
These dresses are amazing on you!
Oooooh Tijana, how I wish I could meet you someday!! Thank you so much for the lovely words!!!
Hahaha! I noticed that your love for red is above and beyond!
You are my favorite human being sweetie!! Your support is beyond, thank you hun!!
Thank you sop much Yuliya!!
You look absolutely beautiful in these gowns, I especially like the red one on you.
Thank you so much Nina, I really appreciate you stopping by!
What a fun shoot! You look beautiful!
The red one is a win for me…. I'm really digging this whole wedding gowns theme.
Am sure the red one would look perfect on you too dear!!
Holy glamorous! Love these gowns! You are such a model. Thanks for sharing doll!
Hahaha!! You say the funniest things Len, thank you darling!!
Wow, once again, you look STUNNING in these gown, Meron! My favorite of the two is the red one, so gorgeous! I can't wait to read your proposal story!!! Thanks so much for sharing, beautiful, and I hope you're having the absolute best day so far!
Thank you so much Jalisa and I love the red one too! Thank you for stopping by darling!!
That yellow one looks amazing on you!
Hahaha! Thank you so much Coco!!
The colored bridal gowns remind me of Disney Princesses! Truly magical!
Awwww! I felt like a Disney princess when I wore them!!
OMG! These colored ball gowns are gorgeous! Love the yellow gown on you! You look like a princess, Meron! Stunning!!
Thank you so much dear!! You are too kind!
You are like a princess! Pretty!
MERON, you seriously look like a Princess! Both of these gowns look incredible on you, you really suit yellow. I am loving your hair and makeup too- stunning!
Thank you so much Rachel and I did feel like a princess when I wore the dresses!
Hahaha! Many have told me that! Thank you!!
I know right, this would be perfect for a Met Ball Galla! Thank you Heather!
This photoshoot is amazing. The dresses look amazing on you!! Wow!
And thank you so much for the sweet comments on my blog about my daughter and I!!!
I agree about switching it up!! Thank you for stopping by Amber!!!
I can say the dresses do justice to your stunningnesssss!!
Hahaha! You are too sweet dear!! Thank you so much!!
I am a proud Aunt. Fashion is in you. The gowns blend well with your shape and brings out the real 'bride' . Never thought a red/yellow gown would make such an elegant dress. You look amaxing. Continue staying fashionable.
Thank you so much aunt, I really appreciate your support. God bless you!
Hahaha! What you said about the white gown is so hilarious!!! Thank you so much for all the compliments and I always try to push myself when it comes to blogging.
I love the yellow gown on you. You look like Belle from Beauty and the Beast. So gorgeous!
Awww! Thank you Lily Rose!!!
wow Meron i literally have know words. But i bet you already know what i am thinking…. but let me drop this that yellow dress is BEAUTIFUL!!!!!!
Hahaha! We are definitely Siamese fashion twins and thank you so much hun!!
Awwww! That is so beautiful to hear dear!!! Thank you so much for stopping by!


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Q: Making a button do something Alright, so I have this little google app I'm trying to put together and am going to have it be based off of crib notes.  There's a text field with a nonfunctioning button that says Add, two radio buttons, and two dropdown menus each either for a book or story.  When I have a radio button checked, text in my text field, and click Add, I'm wanting the text to be sent to one of the dropdown menus.
Here's my HTML so far

Crib Reader

            <input type="radio" name="Reader" value="Book" style="vertical-align: middle" checked="checked">Book
            <input type="radio" name="Reader" value="Story" style="vertical-align: middle">Story

        <input type="text" name="Name" style="height: 20px;">
         <button type="button">Add</button>

            Books

            <select id="Books" style="width: 100px; ">
                <option value=""></option>
            </select>

            <button type="button">Load</button>

            Stories

            <select id="Stories" style="width: 100px; ">
                <option value=""></option>
            </select>

            <button type="button">Load</button>

A: Add an id to the ADD button:
HTML:

            <input type="radio" name="Reader" value="Book" style="vertical-align: middle" checked="checked">Book
            <input type="radio" name="Reader" value="Story" style="vertical-align: middle">Story

        <input type="text" name="Name" style="height: 20px;">
         <button type="button" id="add">Add</button>

Js:
Capture click event and check which radio button is checked and add value in select option accordingly
$("#add").on("click",function(){
 if($('input[name="Reader"]:checked').val() == "Book"){
  $("#Books").append("<option>"+$("input[name='Name']").val()+"</option>");
  }else{
  $("#Stories").append("<option>"+$("input[name='Name']").val()+"</option>");
 }
})


Contributed by Marilyn Davis, Apr 16, 2007, last edited Mar 10, 2008 [davismarilyn@axion.ca]. Total records = 381.
To reach the cemetery, it is the same directions as the Holy Trinity Cemetery in Iron Hill., It is about half way between Iron Hill and Rte 104, sitting on a knoll, or if your coming from Montreal, you take the autoroute # 10 E., exit 78 towards Bromont, then turn right on Blvd Bromont, turn right on Huntington Rd which will become Iron Hill Road, you continue on this road until you come to the Cemetery.
This is a pretty cemetery, clean, well taken care of and still in use. It is the same as most of the cemeteries in the area, old, with stones very difficult to read, situated on Iron Hill Road with no signs as to who takes care of it, or as to what denomination. We enjoyed doing this cemetery, the horses on the other side of the fence kept us company the whole time we were reading it.
Marjorie-Anne Smith and I walked this cemetery in the fall of 2006, transcribing from all existing and legible stones and markers.
Allard, Deborah E., no dates, s/w Louis R.
Allard, Louis R., no dates, s/w Deborah E.
Boule, James R., b. 1933, d. 1997, h/o Sharon M.
Boule, Sharon M., b. 1942, d. no date, w/o James R.
Hadlock, Delmer, b. 1884, d. 1964, h/o Nellie A.
Hadlock, Nellie A., b. 1895, d. 1958, w/o Delmer E.
Hall, Lillian C., b. 1916, d. 2002, s/w Norman S.
Hall, Norman S., b. 1908, d. 1970, s/w Lillian C.
Mersereau, Norma Hanison, b. 1918, d. 1990, w/o Harris G.
Rusbridge, William T., b. 1899, d. 1963, h/o Florence P.
Sheldon, Arthur M., b. 1869, d.
Steady, Zeb, b. Oct 12 1833, d. ????
Sturtevant, Bernice J., b. 1897, d. 1985, w/o Ernest H.
Sturtevant, Ernest H., b. 1891, d. 1955, h/o Bernice J.
Sturtevant, Ethel A.F., b. 1920, d. 1992, s/w Reginald L.
Sturtevant, Reginald L., b. 1919, d. 1965, s/w Ethel A.F.
Swift, James Malcolm, b. Sep 17 1932, d. Sep 22 1987, "interred in Montgomery, Vt.
Tibbits, Eric Melvin, b. Sep 20 1905, d. May 31 1925, s/o John W. & Sarah L.


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The Slatest
The Official Currency of ISIS's Caliphate: the U.S. Dollar
By Joshua Keating
Feb 16, 201612:35 PM
Currency is exchanged inside the Qaysari Bazaar on Dec. 13, 2014 in Erbil, Iraq.
Matt Cardy/Getty Images
ISIS may threaten violence against the United States and aim to rid the Islamic world of U.S. influence and U.S.-backed regimes, but if you want to do business in the group's ersatz caliphate, you'd better have money backed by the full faith and credit of the U.S. government:
The AP reports :
Within the last two weeks, the extremist group started accepting only dollars for "tax" payments, water and electric bills, according to the Raqqa activist, who asked to be identified by his nom de guerre Abu Ahmad for his safety. "Everything is paid in dollars," he said.
Plenty of countries around the world use the dollar either exclusively or accept it in addition to a local currency. Given the other fruits of Western capitalism, from Toyota trucks to Twitter, that ISIS has put to its own uses, perhaps it shouldn't be so surprising that the group relies on the greenback.
Still, it's a change of heart. In late 2014, ISIS announced plans to mint its own gold, silver, and copper Islamic dinar coins with a design overseen by Abu Bakr al-Baghdadi himself, as a way of moving away from the "tyrant's financial system." Turkish police arrested six suspected ISIS members for minting ISIS coins in the city of Gaziantep in October 2015.
The currency plan seems to have never gotten off the ground. The AP reports that the new "dollars only" rule come along with another pay cut for ISIS fighters and the elimination of benefits and perks, from bonuses to "free energy drinks and Snickers bars." The group's finances have reportedly been battered by its loss of territory and airstrikes against its cash stores and oil fields as well as the Iraqi government's decision to stop paying civil servants in areas controlled by the extremists, which reduces the potential money ISIS can collect in taxes. Plummeting global prices have also reduced ISIS's income from its black market oil.
All that sounds promising, but we've been seeing stories predicting ISIS's imminent financial collapse for at least a year. It's still hanging on.
ISIS Syria


text:
Leonidas Sabanis (grekiska: Λεωνίδας Σαμπάνης), född 28 oktober 1971 i Korça i Albanien, är en albansk-grekisk före detta tyngdlyftare. Han vann två silvermedaljer vid olympiska sommarspelen 1996 och 2000.

Källor

Albanska tyngdlyftare
Grekiska tyngdlyftare
Grekiska olympiska silvermedaljörer
Olympiska silvermedaljörer 1996
Olympiska silvermedaljörer 2000
Tävlande vid olympiska sommarspelen 1996 från Grekland
Tävlande i tyngdlyftning vid olympiska sommarspelen 1996
Tävlande vid olympiska sommarspelen 2000 från Grekland
Tävlande i tyngdlyftning vid olympiska sommarspelen 2000
Tävlande vid olympiska sommarspelen 2004 från Grekland
Tävlande i tyngdlyftning vid olympiska sommarspelen 2004
Män
Födda 1971
Levande personer
Personer från Korça
Albanska idrottare under 1900-talet
Albanska idrottare under 2000-talet

redpajama_set_name: RedPajamaWikipedia


Massage spa for men in Denpasar area. King's Palace combines the atmosphere of a spa with relaxation areas with private rooms.
Various treatment options are available and can be customised to your request. These include massage services, Galvanic and High Frequency Facial Treatment and many more. King's therapists are well-trained, fit and have healthy skin.
The spa uses high quality products, both imported and local, proven by certified dermatologists and aesthetics specialists. Walk-in and out-call service available 24 hours.
jo on 25-01-2019 | Reply Problem with this review?
mike on 12-01-2018 | Reply Problem with this review?
"It was raining and mid night already and I found that King Palace open 24 hours and do out call service also thats why i ask their masseur come to my hotel in Nusa Dua.
john on 22-11-2017 | Reply Problem with this review?
dexter on 17-10-2017 | Reply Problem with this review?
Saif on 22-08-2017 | Reply Problem with this review?
"I called the owner in advance to make appointment and he was very responsive. They said I have took taxi online Grab taxi cause its cheapest price and make it easy to find their place I put "soteria Resto" for the place destination as the owner suggestion.
herman on 12-08-2017 | Reply Problem with this review?
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text:
using System;
using System.IO;
using System.Windows.Forms;
using Microsoft.Msagl.Drawing;

namespace TestWpfViewer {
    internal class GmlParser {
        public static Graph Parse(string fileName) {
            var g = new Graph();
            try
            {
                using (var f = new StreamReader(fileName))
                {
                    do
                    {
                        var str = f.ReadLine();
                        if (str == null)
                            return g;
                        ProcessLine(g, str,f);
                    } while (true);
                }
            }
            catch (Exception e)
            {
                MessageBox.Show(e.Message);
            }
            return null;
        }

        static void ProcessLine(Graph graph, string str, StreamReader f) {
            if (str.Contains("node"))
                ReadNode(graph, f);
            else if(str.Contains("edge"))
                ReadEdge(graph, f);

        }

        static void ReadEdge(Graph graph, StreamReader f) {
            f.ReadLine();
            var s = f.ReadLine();
            s = s.Trim(' ', '\t', '"');
            var source = s.Split(' ')[1];
            s = f.ReadLine();

            s = s.Trim(' ', '\t', '"');
            var target = s.Split(' ')[1];
            graph.AddEdge(source, target);
            f.ReadLine();
        }

        static void ReadNode(Graph graph, StreamReader f) {
            f.ReadLine();
            var s=f.ReadLine();
            s = s.Trim(' ', '\t', '"');
            var id = s.Split(' ')[1];
            s = f.ReadLine();
            s = s.Trim(' ', '\t', '"');
            var split = s.Split(' ');
            var label = split[1].Trim('"');
            graph.AddNode(id).LabelText = label;
            f.ReadLine();
        }
    }
}

redpajama_set_name: RedPajamaGithub


An iconic, established and highly successful fashion brand is seeking an experienced accountant to join their finance team. The successful application will be reporting directly to the Financial Controller and be responsible for general ledger reconciliations, preparation of monthly financial statements and assisting the wider finance and management with a wide variety of account duties. This role is available as a fixed term contract for 6 months.
Interested parties please submit your resumes with expected salary and availabilities in MS Word format quoting the job reference LQV/813850 to june.choi@robertwalters.com.hk. Kindly note that only shortlisted candidates will be notified.


Hi , this blog post is about Hover To Zoom ( Leons Dressers #10). This blog post is a image/jpeg and the resolution of this photo is 1245 x 969. This image's file size is just 132 KB. Wether You decided to download This photo to Your PC, you may Click here. You also too download more images by clicking the following image or see more at here: Leons Dressers.
If your Leons Dressers looks clean and clear, undoubtedly you will feel comfortable cooking. With a relaxed kitchen, cooking is enjoyable, because the style of food is determined by the disposition of people who are preparing, along with the result is the maximum that the dinners will taste better.
Therefore, the kitchen additionally takes attention to produce it more intriguing. Also, you will feel better having a home that is nice. Hence kitchen design with ceramic's set which makes it attractive and beautiful. Wall will come in a number of styles, forms, styles, products and also the manifold's installation. You may also use a ceramic wall to some other room, dining bedroom room or toilet.
We have alot about the Hover To Zoom ( Leons Dressers #10)'s design in addition to processes to improve the quality of our kitchen. Now we are going to provide you with some ideas to generate your kitchen more stunning with tiled surfaces. Your kitchen is usually found away and indoors from the entry, but there is also a kitchen that is simply obvious in the living area.
Layout your home with gorgeous, then your mood may also be usually good-and the cook became awesome. Here we fix some trial photographs kitchen using a minimalist design, having a kitchen such as this inside the kitchen you will generally untouched.


text:
<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd">

<title>Uses of Class main.Circle2D</title>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="date" content="2018-08-26">
<link rel="stylesheet" type="text/css" href="../../stylesheet.css" title="Style">
<link rel="stylesheet" type="text/css" href="../../jquery/jquery-ui.css" title="Style">

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Uses of Class
main.Circle2D

Uses of Circle2D in main

Methods in main with parameters of type Circle2D

Modifier and Type
Method
Description

boolean
Circle2D.contains(Circle2D circle)

Returns if the given circle is inside this circle.

boolean
Circle2D.overlaps(Circle2D circle)

Returns if the given circle overlaps this circle.

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text:
Cookie Policy for Alessandra Pezzati Wedding Photographer
This is the Cookie Policy for Alessandra Pezzati Wedding Photographer, accessible from www.alessandrapezzati.it
Site preferences cookies
In order to provide you with a great experience on this site we provide the functionality to set your preferences for how this site runs when you use it. In order to remember your preferences we need to set cookies so that this information can be called whenever you interact with a page is affected by your preferences.
From time to time we test new features and make subtle changes to the way that the site is delivered. When we are still testing new features these cookies may be used to ensure that you receive a consistent experience whilst on the site whilst ensuring we understand which optimisations our users appreciate the most.
We also use social media buttons and/or plugins on this site that allow you to connect with your social network in various ways. For these to work the following social media sites including; {List the social networks whose features you have integrated with your site?:12}, will set cookies through our site which may be used to enhance your profile on their site or contribute to the data they hold for various purposes outlined in their respective privacy policies.
Hopefully that has clarified things for you and as was previously mentioned if there is something that you aren't sure whether you need or not it's usually safer to leave cookies enabled in case it does interact with one of the features you use on our site. This Cookies Policy was created with the help of the Cookies Policy Template Generator and the Terms and Conditions Template.
Email: pezzati.ale@gmail.com


We are a small family owned company, run by two brothers, Carlos and Javier. We manage a family vineyard with extraordinary characteristics and a premium location mainly in Laguardia and Labastida regions, allowing us to produce a high quality range of wines. These are modern style fruity wines, honest and adapted to current consumer preferences.
Our main values are focusing on the quality of our wines and taking care of our clients. Building a strong and long term relationship with our customers based on the confidence given by the quality of our wines and the personal and close relationship that we try to offer is of the utmost importance to us.
©2014 Viña Eizaga. All rights reserved.


text:
using System;
using System.Threading;
using Arch.CMessaging.Client.Net.Core.Session;
using System.Diagnostics;

namespace Arch.CMessaging.Client.Net.Filter.Executor
{
    public class IoEventQueueThrottle : IoEventQueueHandler
    {
        private volatile Int32 _threshold;
        private readonly IoEventSizeEstimator _sizeEstimator;
        private readonly Object _syncRoot = new Byte[0];
        private Int32 _counter;
        private Int32 _waiters;

        public IoEventQueueThrottle()
            : this(new DefaultIoEventSizeEstimator(), 65536)
        { }

        public IoEventQueueThrottle(Int32 threshold)
            : this(new DefaultIoEventSizeEstimator(), threshold)
        { }

        public IoEventQueueThrottle(IoEventSizeEstimator sizeEstimator, Int32 threshold)
        {
            if (sizeEstimator == null)
                throw new ArgumentNullException("sizeEstimator");
            _sizeEstimator = sizeEstimator;
            Threshold = threshold;
        }

        public Int32 Threshold
        {
            get { return _threshold; }
            set
            {
                if (value <= 0)
                    throw new ArgumentException("Threshold should be greater than 0", "value");
                _threshold = value;
            }
        }

        public Boolean Accept(Object source, IoEvent ioe)
        {
            return true;
        }

        public void Offered(Object source, IoEvent ioe)
        {
            Int32 eventSize = EstimateSize(ioe);
            Int32 currentCounter = Interlocked.Add(ref _counter, eventSize);

            Debug.WriteLine(Thread.CurrentThread.Name + " state: " + _counter + " / " + _threshold);

            if (currentCounter >= _threshold)
                Block();
        }

        public void Polled(Object source, IoEvent ioe)
        {
            Int32 eventSize = EstimateSize(ioe);
            Int32 currentCounter = Interlocked.Add(ref _counter, -eventSize);

            Debug.WriteLine(Thread.CurrentThread.Name + " state: " + _counter + " / " + _threshold);

            if (currentCounter < _threshold)
                Unblock();
        }

        protected void Block()
        {
            Debug.WriteLine(Thread.CurrentThread.Name + " blocked: " + _counter + " >= " + _threshold);

            lock (_syncRoot)
            {
                while (_counter >= _threshold)
                {
                    _waiters++;
                    try
                    {
                        Monitor.Wait(_syncRoot);
                    }
                    catch (ThreadInterruptedException)
                    {
                        // Wait uninterruptably.
                    }
                    finally
                    {
                        _waiters--;
                    }
                }
            }

            Debug.WriteLine(Thread.CurrentThread.Name + " unblocked: " + _counter + " < " + _threshold);
        }

        protected void Unblock()
        {
            lock (_syncRoot)
            {
                if (_waiters > 0)
                {
                    Monitor.PulseAll(_syncRoot);
                }
            }
        }

        private Int32 EstimateSize(IoEvent ioe)
        {
            Int32 size = _sizeEstimator.EstimateSize(ioe);
            if (size < 0)
                throw new InvalidOperationException(_sizeEstimator.GetType().Name + " returned "
                        + "a negative value (" + size + "): " + ioe);
            return size;
        }
    }
}


text:
Lazy Search Music Plugin
Sat, 10/03/2007 - 14:04 — Stuart Hickinbottom
The Lazy Search Music plugin for SlimDevices' Squeezebox is an enhancement plugin that I've been developing for a number of years.
The plugin provides an alternative to the standard Search Music method available through the player's remote control. Whilst the standard search requires multiple button pushes to enter each character, Lazy Searching avoids that whilst providing a more dynamic search method with seach results being returned as the search is entered.
It's easier to understand when you see it in action, so below is a video demonstration of the plugin in action through the Softsqueeze player. This demonstration shows entering DARK in order to try to find the album "Dark Side of the Moon" - this takes just four button presses compared with the eight needed with the standard search.
The plugin is documented and developed on the mini site available from the menu at the top of this website, and at the following location:
http://www.hickinbottom.com/lazysearch


Easy Go Traveler Members know which credit cards offer the most value.
So, which credit card option is right for you?
Many of the listings that appear on this website are from companies from which we may receive compensation. This compensation may impact how and where products appear on this site (including, for example, the order in which they appear). The site does not review or include all companies or all available products.


text:
当前位置:首页 > 工控技术 > HMI > SIEMENS AG SIMATIC S5 CPU Direct
SIEMENS AG SIMATIC S5 CPU Direct
1Siemens AG SIMATIC S5 CPU Direct Driver1System Configuration.......................................................................................................32Selection of External Device............................................................................................73Example of Communication Setting.................................................................................84Setup Items......................................................................................................................95Cable Diagram...............................................................................................................146Supported Device...........................................................................................................157Device Code and Address Code....................................................................................168Error Messages..............................................................................................................17SIMATIC S5 CPU Direct Driver GP-Pro EX Device/PLC Connection Manual2PREFACEThis manual describes how to connect the Display and the External Device (target PLC).In this manual, the connection procedure will be described by following the below sections:1System ConfigurationThis section shows the types of External Devices which can be connected and SIO type.�"1 System Configuration" (page 3)2Selection of External DeviceSelect a model (series) of the External Device to be connected and connection method.�"2 Selection of External Device" (page 7)3Example of Communication SettingsThis section shows setting examples for communicating between the Display and the External Device.�"3 Example of Communication Setting" (page 8)4Setup ItemsThis section describes communication setup items on the Display.Set communication settings of the Display with GP-Pro EX or in offline mode.�"4 Setup Items" (page 9)Operation5Cable DiagramThis section shows cables and adapters for connecting the Display and the External Device.�"5 Cable Diagram" (page 14)SIMATIC S5 CPU Direct Driver GP-Pro EX Device/PLC Connection Manual31System ConfigurationThe system configuration in the case when the External Device of Siemens AG and the Display are connected is shown.�Connection Configuration[1:1 Connection]Series NameCPULink I/FSIO TypeSetting ExampleCable DiagramSeries90U-115U CPU 90UCPU 95UCPU 100CPU 102CPU 103CPU 941CPU 942CPU 943CPU 944CPU 945PG port on CPURS232CSetting Example 1 (page 8)Cable Diagram 1 (page 14)Series135U/155U CPU 922CPU 928CPU 928BCPU 946CPU 947CPU 948PG port on CPURS232C•Set the execution time of the logic functions in the Display to "100 ms" or less. If the longer time is set, an error may occur in the communication with the external device.DisplayExternal DeviceCA6-CBLTTY/5M-01SIMATIC S5 CPU Direct Driver GP-Pro EX Device/PLC Connection Manual4�IPC COM PortWhen connecting IPC with an External Device, the COM port used depends on the series and SIO type. Please refer to the IPC manual for details.Usable portSeriesUsable PortRS-232CRS-422/485(4 wire)RS-422/485(2 wire)PS-2000BCOM1*1, COM2, COM3*1, COM4*1The RI/5V can be switched. Use the IPC's switch to change if necessary.--PS-3450A, PS-3451A,PS3000-BA, PS3001-BDCOM1, COM2*1*2COM2*1*2COM2*1*2PS-3650A (T41 model),PS-3651A (T41 model)COM1*1--PS-3650A (T42 model),PS-3651A (T42 model)COM1*1*2, COM2COM1*1*2COM1*1*2PS-3700A (Pentium®4-M)PS-3710ACOM1*1, COM2*1, COM3*2, COM4*2Set up the SIO type with the DIP Switch. Please set up as follows according to SIO type to be used.COM3*2COM3*2PS-3711ACOM1*1, COM2*2COM2*2COM2*2PS4000*3*3When making communication between an External Device and COM port on the Expansion slot, only RS-232C is supported. However, ER (DTR/CTS) control cannot be executed because of the specification of COM port. For connection with External Device, use user-created cables and disable Pin Nos. 1, 4, 6 and 9. Please refer to the IPC manual for details of pin layout.COM1, COM2--PL3000COM1*1*2, COM2*1, COM3, COM4COM1*1*2COM1*1*2PE-4000B Atom N270COM1, COM2--PE-4000B Atom N2600COM1, COM2COM3*4, COM4*4, COM5*4, COM6*4*4Set up the SIO type with the BIOS. Please refer to the IPC manual for details of BIOS.COM3*4, COM4*4, COM5*4, COM6*4PS5000 (Slim Panel Type Core i3 Model) *5 *6COM1, COM2*4COM2*4COM2*4PS5000 (Slim Panel Type Atom Model) *5 *6COM1, COM2*7COM2*7COM2*7PS5000 (Enclosed Panel Type)*8COM1--PS5000 (Modular Type) *5 *6COM1*7COM1*7COM1*7SIMATIC S5 CPU Direct Driver GP-Pro EX Device/PLC Connection Manual5DIP Switch settings (PL3000 / PS3000 Series)RS-232C*5When setting up communication between an External Device and the RS-232C/422/485 interface module, use the IPC (RS-232C) or PS5000 (RS-422/485) cable diagrams. However, when using PFXZPBMPR42P2 in a RS-422/485 (4-wire) configuration with no flow control, connect 7.RTS+ and 8.CTS+, and connect 6.RTS- and 9.CTS-. When using RS-422/485 communication with External Devices, you may need to reduce the transmission speed and increase the TX Wait time.*6To use RS-422/485 communication on the RS-232C/422/485 interface module, the DIP Switch setting is required. Please refer to "Knowledge Base" (FAQs) on the support site. (http://www.pro- face.com/trans/en/manual/1001.html)*7Set up the SIO type with the DIP Switch. Please refer to the IPC manual for details of DIP Switch.*8For the connection with the External Device, on the user-created cable read as if the connector on the Display-side is a M12 A-coding 8 pin socket. The pin assignment is the same as described in the cable diagram. For the M12 A-coding connector, use PFXZPSCNM122.DIP SwitchSettingDescription1OFF*1*1When using PS-3450A, PS-3451A, PS3000-BA and PS3001-BD, turn ON the set value.Reserved (always OFF)2OFFSIO type: RS-232C3OFF4OFFOutput mode of SD (TXD) data: Always output5OFFTerminal resistance (220Ω) insertion to SD (TXD): None6OFFTerminal resistance (220Ω) insertion to RD (RXD): None7OFFShort-circuit of SDA (TXA) and RDA (RXA): Not available8OFFShort-circuit of SDB (TXB) and RDB (RXB): Not available9OFFRS (RTS) Auto control mode: Disabled10OFFSettingsFAQ IDPFXZPBMPR42P2, RS422/485 change methodFA263858PFXZPBMPR42P2 termination resistor settingFA263974PFXZPBMPR44P2, RS422/485 change methodFA264087PFXZPBMPR44P2 termination resistor settingFA264088
文档介绍: SIEMENS AG SIMATIC S5 CPU Direct
SIEMENS AG SIMATIC S5 CPU Direct 39
Siemens AG SIMATIC S7 MPI Direct 35
Siemens AG SIMATIC S5 3964(R) 31
SIEMENS AG SIMATIC S7 Ethernet 33
SIEMENS AG SIMATIC S7 3964(R)RK512 31
Siemens AG Ethernet Gateway for SIMATIC MPIPROFIBUS 45
SIMATIC S7-1500 软件控制器 CPU 1505SP (FTTF)、 CPU 1507S (F)、CPU 1508S (F) V2.6 操作说明 75
SIMATIC S7 MPI Direct Driver Pass-Through Function Guide 37
SIEMENS AG TIA Portal Ethernet 37
Mitsubishi Electric Corporation Q Series CPU Direct 34


text:
Zombiaki – taktyczna gra karciana dla dwóch graczy wydana przez Portal w roku 2002, w której Zombie walczą z Ludźmi. Autorem gry jest Ignacy Trzewiczek.

Gra składa się z dwóch talii, w których znajduje się po 40 kart i 5 kart pola. Karty są ilustrowane rysunkami odpowiednio Zombie, jak i Ludzi.

Zasady
Na stole rozkładana jest plansza z kart symbolizująca ulicę prowadzącą z Cmentarza do miasta, która stanowi 5 kart pokazujących odległość miasta od Cmentarza. Celem gry dla strony Zombie jest dojście do miasta, a celem Ludzi uniemożliwienie im tego za wszelką cenę. Następnie każdy z graczy dobiera po 5 kart ze swojego stosu.

Rozpoczyna gracz grający Zombie poprzez wystawienie 2 kart na polach najbliżej Cmentarza. Następnie osoba grająca Ludźmi w swojej turze odpowiada swoimi kartami akcji, które są dostępne, między innymi: strzał z pistoletu, beczka z płonącym olejem, granat, miotacz ognia. W kolejnej turze Zombie przesuwane są o jedno pole do przodu. Gra kończy się wygraną Ludzi, gdy pojawi się karta Świt w zestawie gracza używającego Zombich, lub wygraną Zombich, jeżeli któryś z nich dotrze do linii Ludzi.

W kwietniu 2010 roku wydana została druga wersja gry: Zombiaki 2: Atak na Moskwę, także autorstwa Trzewiczka. W magazynie Esensja ta wersja została wyróżniona jako jedna z najlepszych gier dekady. W marcu 2013 roku pojawiło się wydanie jubileuszowe gry z okazji dziesięciolecia jej powstania.

Przypisy

Linki zewnętrzne
  - videocast w serwisie GryPlanszowe.net
 Zombiaki w serwisie BoardGameGeek

Gry karciane
Polskie gry


text:
Aparna Nathan
To keep rogue tumor cells in check, sometimes the best defense is the body's own immune system. Engineering safe and effective immunotherapies that work for many people with diverse tumors can be challenging. Rubius Therapeutics is trying to make immunotherapies better by calling on a surprising blood cell: red blood cells (RBCs).
RBCs are not traditional immune cells like better-known T cells or macrophages; they don't attack foreign invaders, and their ability to prompt other cells' killing abilities is just starting to be harnessed. In a study recently published in Nature Communications, a team from Rubius Therapeutics reported that they had engineered RBCs to present tumor antigens that signal T cells to attack the tumor. In preclinical studies, they use these artificial antigen-presenting cells (aAPCs) to target HPV-driven cancers, which have traditionally been a target for checkpoint-blockade immunotherapies.
"The ability to block inhibitory pathways has been of great benefit to patients," said Larry Turka, chief scientific officer of Rubius Therapeutics. "But clearly, it hasn't been a panacea for everybody. Not everyone has benefited from it, and sometimes benefits are relatively short term."
Building a better immune cell
Rubius Therapeutics focuses on a different part of the immune response: the cells that put T cells on the tumor's scent. APCs such as macrophages or dendritic cells have surface molecules called human leukocyte antigens (HLA) that hold a foreign antigen. Some cells such as T and B cells take note of the foreign antigens the APCs present, and use them to recognize and attack invaders throughout the body.
In cancer, APCs don't always do a good job of training T cells to recognize tumors. "What we think is that natural APCs are sleeping on the job," said Marcela Maus, an immuno-oncologist at Harvard Medical School and Mass General Cancer Center who was not involved in this study. "Maybe they're patrolling and presenting things, but it doesn't look foreign enough to really wake up an immune response, or they're not presenting enough of it, or in the wrong context."
Rubius Therapeutics decided to engineer a better APC to present a tumor antigen. They use precursors of RBCs as the base and insert genes using a viral vector to express thousands of copies of HLA. HLA holds the tumor antigen flanked by two other molecules called 4-1BBL and IL-12, which prod T cells to replicate and attack. Because of RBCs' unique developmental path, the precursors lose their nuclei before becoming RBCs; the genes are ejected from the cell, but the surface proteins remain.
While this isn't the first attempt to make aAPCs for cancer, Maus said the use of viral vector-based genetic engineering, and the fact that it doesn't require complex technologies like CRISPR make it novel.
"This crosses a lot of boundaries," Maus said.
Off-the-shelf immunotherapy
Unlike other cellular immunotherapies that require custom-engineered cells designed for a specific patient's tumor, Rubius Therapeutics is developing a single off-the-shelf product that can be prescribed to any eligible patient. Turka imagines manufacturing a product that can be frozen, then thawed and shipped for administration through pharmacies. Nabil Saba, an immuno-oncologist at Emory University's Winship Cancer Institute, said that this kind of simplicity might make the technology stand out from complicated T cell engineering efforts.
Red blood cells (red) have been engineered into artificial antigen presenting cells to activate T cells (green).
CREDIT: RUBIUS THERAPEUTICS
In their new study, the researchers engineered aAPCs from mouse RBCs to target a protein that they artificially expressed in mouse tumors. These aAPCs stimulated replication of T cells that recognized the antigen and produced defense molecules to inhibit tumor growth. The engineered cells even promoted the activation of T cells that recognized other tumor antigens not presented by the aAPC, a phenomenon called epitope spreading that Turka finds an encouraging sign.
HPV-driven cancers often retain pieces of viral protein, making them good candidates for immunotherapy, so Turka's team also engineered aAPCs to target cancers caused by HPV infection, such as some head and neck, cervical, and anal cancers. These aAPCs, called RTX-321, present an HPV protein called E7. When mixed with T cells, they activate and expand E7-recognizing T cells.
Scratching the surface
Rubius Therapeutics' aAPCs remind both Maus and Saba of vaccines because of the way they stimulate the immune system to recognize and respond to specific targets. Maus thinks that there's potential to use this type of technology with a broader range of cancer molecules, and the team at Rubius Therapeutics is already at work designing an aAPC with a more customizable HLA molecule that can be loaded with any target molecule. They're also planning a study with aAPCs without any HLA at all, just the co-stimulatory 4-1BBL and IL-12, which seem to have some anti-tumor effects on their own.
"For most cancers, we don't know the antigens, so there's a lot of needy patients for whom we don't know what antigen to put on," Turka said.
One advantage of red blood cells is that they have fewer markers that might seem foreign to a recipient's immune system. Turka estimates that 95% of people can receive a red blood cell transfusion without rejecting it. Red blood cells also stay in the blood vessels and spleen, making it less likely that they'll wreak havoc throughout the body.
"To be able to show that not only do we have an effective therapy, but it's actually safe in vivo was very promising for us as we try to move this forward," said Tiffany Chen, a scientific director at Rubius Therapeutics and senior author of the study.
But that doesn't mean that the therapy will work in everyone; the current formulation uses one common version of HLA out of the tens of versions that different people have. Patients would only be able to use this therapy if their HLA molecule matches the version on the red blood cells.
Clinical trials will be the real test of safety and efficacy. Rubius Therapeutics has started enrolling participants for a Phase 1 clinical trial. They also have a similar RBC-based aAPC targeted for lung cancer that's further along in clinical trials, and preliminary data show that the drug is safely tolerated. In another trial, they are testing how the lung cancer aAPC works in combination with checkpoint blockade as a way to ramp up the T cell response.
"We're still scratching the surface of the immune environment and how to use the immune system to target HPV-related cancer," Saba said. "We certainly live in a very exciting time in terms of immunotherapy."
Zhang, X., et al. Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic. Nat Comms 12, 2637 (2021).
Topics:Cancer Research,Disease Focus,Immunology
Tags:Cancerimmunotherapiesred blood cells
Meet the microrobots primed to take down cancer
Larva therapy makes a comeback
CAR T cell therapy gives glioblastoma patients hope
Targeting gut bacteria to treat autism


text:
import os
import re
import shutil

from oslo_concurrency import processutils
from oslo_config import cfg
from oslo_log import log as logging

from backup.drivers import base

CONF = cfg.CONF
LOG = logging.getLogger(__name__)

class MySQLBaseRunner(base.BaseRunner):
    def __init__(self, *args, **kwargs):
        self.datadir = kwargs.pop('db_datadir', '/var/lib/mysql/data')

        super(MySQLBaseRunner, self).__init__(*args, **kwargs)

    @property
    def user_and_pass(self):
        return ('--user=%(user)s --password=%(password)s --host=%(host)s' %
                {'user': CONF.db_user,
                 'password': CONF.db_password,
                 'host': CONF.db_host})

    @property
    def filename(self):
        return '%s.xbstream' % self.base_filename

    def check_process(self):
        """Check the backup output for 'completed OK!'."""
        LOG.debug('Checking backup process output.')
        with open(self.backup_log, 'r') as backup_log:
            output = backup_log.read()
            if not output:
                LOG.error("Backup log file %s empty.", self.backup_log)
                return False

            last_line = output.splitlines()[-1].strip()
            if not re.search('completed OK!', last_line):
                LOG.error(f"Backup did not complete successfully, last line:\n"
                          f"{last_line}")
                return False

        return True

    def get_metadata(self):
        LOG.debug('Getting metadata for backup %s', self.base_filename)
        meta = {}
        lsn = re.compile(r"The latest check point \(for incremental\): "
                         r"'(\d+)'")
        with open(self.backup_log, 'r') as backup_log:
            output = backup_log.read()
            match = lsn.search(output)
            if match:
                meta = {'lsn': match.group(1)}

        LOG.info("Updated metadata for backup %s: %s", self.base_filename,
                 meta)

        return meta

    def incremental_restore_cmd(self, incremental_dir):
        """Return a command for a restore with a incremental location."""
        args = {'restore_location': incremental_dir}
        return (self.decrypt_cmd + self.unzip_cmd + self.restore_cmd % args)

    def incremental_prepare_cmd(self, incremental_dir):
        if incremental_dir is not None:
            incremental_arg = '--incremental-dir=%s' % incremental_dir
        else:
            incremental_arg = ''

        args = {
            'restore_location': self.restore_location,
            'incremental_args': incremental_arg,
        }

        return self.incremental_prep % args

    def incremental_prepare(self, incremental_dir):
        prepare_cmd = self.incremental_prepare_cmd(incremental_dir)

        LOG.info("Running restore prepare command: %s.", prepare_cmd)
        processutils.execute(prepare_cmd, shell=True)

    def incremental_restore(self, location, checksum):
        """Recursively apply backups from all parents.

        If we are the parent then we restore to the restore_location and
        we apply the logs to the restore_location only.

        Otherwise if we are an incremental we restore to a subfolder to
        prevent stomping on the full restore data. Then we run apply log
        with the '--incremental-dir' flag

        :param location: The source backup location.
        :param checksum: Checksum of the source backup for validation.
        """
        metadata = self.storage.load_metadata(location, checksum)
        incremental_dir = None

        if 'parent_location' in metadata:
            LOG.info("Restoring parent: %(parent_location)s, "
                     "checksum: %(parent_checksum)s.", metadata)

            parent_location = metadata['parent_location']
            parent_checksum = metadata['parent_checksum']
            # Restore parents recursively so backup are applied sequentially
            self.incremental_restore(parent_location, parent_checksum)
            # for *this* backup set the incremental_dir
            # just use the checksum for the incremental path as it is
            # sufficiently unique /var/lib/mysql/<checksum>
            incremental_dir = os.path.join('/var/lib/mysql', checksum)
            os.makedirs(incremental_dir)
            command = self.incremental_restore_cmd(incremental_dir)
        else:
            # The parent (full backup) use the same command from InnobackupEx
            # super class and do not set an incremental_dir.
            LOG.info("Restoring back to full backup.")
            command = self.restore_command

        self.restore_content_length += self.unpack(location, checksum, command)
        self.incremental_prepare(incremental_dir)

        # Delete after restoring this part of backup
        if incremental_dir:
            shutil.rmtree(incremental_dir)


text:
The Retail Impact of the Apple Watch
The first wave of consumers start receiving their Apple Watches, and retailers are ready.
By Rachel Strugatz on April 23, 2015
Retailers are ready for shoppers armed with Apple Watches.
This story first appeared in the April 24, 2015 issue of WWD. Subscribe Today.
The first wave of consumers — the millions who made the preorder window — will start receiving their watches today. Everyone else will have to wait until June, when the smartwatch begins shipping in earnest and hits Apple stores.
Merchants have been quick to develop apps for the watch, with Target, QVC, Etsy, Kohl's, eBay and Asos all jumping in.
The benefits could be huge if the smartwatch becomes a steady shopping companion.
Analysts estimate that Apple could sell about 20 million Apple Watches this year. Prices start at $349 for sport models with aluminum casing and fluoroelastomer bands to $10,000 for 18-karat yellow or rose gold casings with leather bands and corresponding gold buckles and clasps.
RELATED STORY: Fashion Retailers Get Behind Apple Watch >>
While the experience is largely an extension of the smartwatch's companion iPhone app (the majority of sales will still take place on the phone), the Apple Watch is the latest tool for merchants wanting to become omnichannel retailers.
Kohl's, for instance, has been developing its smartphone experience and driven more than 5.5 million downloads for its app since October, with many people using its proprietary mobile wallet feature that is home to its Yes2You Rewards and Kohl's Cash programs.
The retailer wants to keep that momentum going with the Apple Watch.
Ratnakar Lavu, Kohl's executive vice president of digital technology, said there were great opportunities to use the Apple Watch to reach customers while they're in one of the retailer's 1,164 doors.
"All the loyalty rewards and Kohl's Cash that are part of your mobile wallet can be easily shown on the watch, and they don't need to pick up the phone to see the wallet," Lavu said.
He added that in the future, they would like the app to include notifications, so that a consumer who enters one of the company's stores would get a message notifying them how much Kohl's Cash they have in their account.
Pure-plays are also looking to take advantage of the watch.
"Our mantra is to deliver the Asos experience at the swipe of your thumb," Nick Beighton, Asos chief operating officer, told WWD Thursday. "This is not me telling you that keyboards are dead. What this is saying is that customers are increasingly showing that they want access to our experience in a device agnostic way, increasingly through a smartphone."
But this will soon evolve to the swipe of an Apple Watch, with what Beighton described as a series of push notifications that are calls to action, but carry less friction than the smartphone experience. For instance, if a user liked a dress in the app and saved the item for later, she will get a notification on her watch if it's low in stock so that she can add it to her bag and head to her computer or phone to buy it before it sells out.
Currently, 51 percent of the U.K.-based site's global traffic comes from mobile. (Mobile accounts for 60 percent of all traffic in the U.K. and 80 percent of traffic in China, through Tmall.com.)
According to Ben Bajarin, an analyst at Creative Strategies, one of the most attractive elements of the watch for developers is that it offers the value of the digital world in a hands-free environment. He explained that if someone is walking through a store, it's not likely that they're staring at their phone the entire time — and the Apple Watch facilitates a digital experience without having to actively use one's phone.
He cited Target's Apple Watch app, which lets consumers build a list and once in store, the app guides them exactly to where each item is located. This already exists on the retailer's iPhone app, but on the watch, although the tool is the same, it has a different use case.
"Certainly you can get all of this on your phone, but the point is that you aren't staring at your phone 24/7," Bajarin said. "The Target app is interesting because it has the deals and gives you coupons you have on your list and navigates you there if you're pushing a cart or carrying a bag."
Thus far, it appears one of the most useful tools on the watch is its nearly seamless Apple Pay integration. With two taps on the side of the watch, payment information is ready to be processed at terminals that accept Apple Pay. The tech giant said that as of last month more than 2,500 bank credit unions are on board to bring Apple Pay to millions, with the service available in 700,000 locations, from Whole Foods to Sephora.
Experts predict that the feature could eventually have a significant impact on the mobile payment space. While the entire process for Uber, for example, occurs within the confines of the watch, the retail world is focused on using the gadget to help facilitate purchases in-store or on an iPhone.
Etsy, which is gearing up for its initial public offering, already sees more than half of visits to Etsy.com coming from mobile devices. As of the end of the last year, the marketplace's smartphone app had been downloaded 21.8 million times. The brand's Apple Watch experience will give shoppers personalized recommendations and shipping notifications and let them interact with sellers.
"We're still unsure if users will actually purchase using the watch or it's just a tool to use alongside and make the purchase on iPhone," said Arpan Podduturi, Etsy group product manager of mobile.
QVC is also primed for heavy Apple Watch usage, according to Alex Miller, the company's senior vice president of digital commerce.
With an iPhone and iPad app that has seen nearly 3 million downloads, Miller said introduction of the Apple Watch will help QVC leverage "check-in type content."
"The usage pattern is different," Miller said of QVC's highly engaged consumer. "There is much more usage throughout the day. Our brand is uniquely positioned to encourage checking in — we're introducing new content all day, every day. It's the most visible on live TV, and it encourages this check-in behavior.
He said the best customers check in multiple times per day. They want to access core items like Today's Special Value and QVC's best find of the day in a snackable way so they can order as efficiently and quickly as possible.
Miller said a mobile-first approach has been the digital strategy for several years — and that the move to the wrist is a natural extension of the shopper's need to visit QVC over the course of the day. He cited an easy handoff to the iPhone app if the consumer wishes to engage further.
He acknowledged that a challenge for retailers will be in developing an experience that works on such a small screen. But once they do, he predicted that future watch experiences won't be tethered to an iPhone app. For the time being, users can start their journey on the Apple Watch, but are ultimately directed back to their iPhones to complete the transaction.
"The fact that they have to do a handoff on to a phone isn't ideal," Miller admitted, although he remained optimistic about how QVC's Apple Watch app could enhance the mobile and overall shopping experience.


text:
Tag: Pottstown High School
Hairspray Opening This Weekend At PHS
Over the last 5 years, the Pottstown High School Musical program has taken us from Rydell High to the City of Oz, from Skid Row to under the sea.
This year, the scene is 1960's Baltimore! A cast of over 80 talented teens will present the hit Broadway musical Hairspray in the Davenport Auditorium March 1-3. Add in stage crew, lighting, and hair and makeup and you've got over a hundred students working to bring this production to life. Long days with rehearsals stretching almost to midnight are just about over and the students are ready for opening night this weekend!
If you aren't familiar with the plot of Hairspray, it's the story of Tracy Turnblad, a chubby, vivacious teenager with dreams of dancing on the Corny Collins Show, specifically with her crush, Link Larkin. It's not just about young love; the story is set in a city undergoing massive change. The show, and in larger part, the community is wrestling with ongoing segregation that
But, Tracy and her best friend Penny are out to change things for everyone! Hairspray is ultimately about breaking stereotypes and changing the culture of the community, with lots of teen hormones, catchy music, and great dance numbers thrown in.
So, come on out this weekend for a great show and lots of hairspray!
The show opens tomorrow, March 1st at 7pm, with another evening performance Saturday March 2nd at 7pm and a matinee at 2pm in the Davenport Auditorium at Pottstown High School.
Tickets can be purchased online or at the door
https://www.showtix4u.com/events/15289
Grumpy's and PHS Culinary Arts students to unveil new sandwich today!
Stop by Grumpy's Hand-Carved Sandwich Shop at 137 East High Street anytime after 11 am TODAY, when the festivities will get underway to unveil a new sandwich created by the Pottstown High School winners of the Chopped competition.
The winning team of Hannah Irvin and Alyssa Vanish, shown here with Sheila and Gene Dugan, will be on hand with their classmates to celebrate and promote the culinary arts program at the high school.
Wednesday is still veggie day at Grumpy's! Here's the menu for today:
SOUPS: fava bean soup / chicken orzo
SANDWICH: roasted pepper and fresh mozzerella wrap
THE IRVANISH SPECIAL: Presented today for the first time!
SIDES: freeken salad, blackeyepeas with barley salad
Come out and meet the talented students of PHS Culinary Arts!
POTTSTOWN STUDENT GOVERNMENT WANTS YOUR BLOOD
This comes to us via John Armato at the School District…
Pottstown High School Student Government is hosting a blood drive on November 16th. It will be held in the high school band room and will begin at 7:30 AM.
The requirements for someone to donate blood are:
must be 17 years of age
must be at least 110 pounds
must not have received a tattoo or body piercing within the last year.
You must register in advance by Nov. 13th! To donate contact Mr. Mark Agnew at magnew@pottstownsd.org with name and time you would like to donate on Nov. 16th. If you have any questions please do not hesitate to ask.
Blood transfusions save more than 4 million lives each year. Student Government President Megan O'Donnell reminds all "it is estimated that blood is needed every two seconds, and that 1 out of 7 people entering the hospital will need blood. Since blood cannot be manufactured or harvested, it can only come from people like YOU – the volunteer blood donor! Thank you in advance!"
DEADLINE TO REGISTER IS NOVEMBER 13. THERE WILL BE NO WALK-INS THAT DAY. Enter at the High School main office.
Hurricane Sandy safety info for Pottstown
Thanks to The Mercury, Roy's Rants, Warren Holohan of Ink and Essence, and John Armato for all these pieces of info below to help Pottstown residents keep themselves safe. If new info comes to me, I will get it up ASAP. Stay inside and take care!
Pottstown High School is a Red Cross emergency shelter during the storm. It was open last night and will be open during the emergency. The High School is at 750 N. Washington Street. You can enter at the gym area.
Christ Episcopal Church at 316 E. High Street near the Farmers' Market announced it is open for shelter and sanctuary for anyone in need due to protracted loss of electric, flooding or other catastrophes resulting from the storm. Bedding and other essentials have been put into place. Contact Rev. Terry Highland at the church for more details: 610-323-2895.
In Pottstown, Hanover Street between Third and Fourth Streets has been closed for low tree branches and power lines.
The Coventry Mall will close at 2 p.m. today.
However, as of 10:30 a.m., Wal-Mart, K-Mart and Target all planned to remain open throughout the day.
Use this link here to access The Mercury's regional storm updates as Sandy barrels through.
Groundhog Day 2023 photos: Punxsutawney Phil makes his prediction February 2, 2023
Did Punxsutawney Phil see his shadow? See pics from Groundhog Day 2023.
John Misinco


text:
OPINION: Dear Conan, Newark Is Not Funny
From NYTimes.com:
Conan O'Brien has been making some pretty rough jokes about Newark, which has led to a (mostly) mock feud between the late-night host and Newark Mayor Cory Booker.
O'Brien joked that the mayor was establishing a program to improve the health of the city's residents, then deadpanned: "The health care program would consist of a bus ticket out of Newark."
He did a video bit in which he praised the city's "thriving arts scene" (while showing a graffiti-scarred wall); its "four-star lodging" (shots of abandoned, gutted, rusting vehicles); and its "world-class live theater" (a peep show).
He threatened to form an alliance with the mayors of nearby municipalities, thus "creating a geographic toilet seat around the city of Newark," making it possible to flush the city down the figurative bowl.
The mayor came up with his own YouTube videos in response and, believe it or not, Secretary of State Hillary Rodham Clinton weighed in at one point as a mock peace negotiator.
Conan seems like a nice fellow, and I doubt that he harbors any malice toward Newark. But he and his audience are having fun taunting a city that, like many others across the U.S., is in a desperately tragic situation: poverty-stricken, run down, often unsafe, its children and teenagers in too many instances going nowhere fast.
Whether it's Newark, Detroit, parts of Chicago, South-Central Los Angeles, Camden, N.J. — take your pick — we've looked the other way for decades as the residents of hard-core inner-city neighborhoods struggled with overwhelming, life-threatening problems and a chronic shortage of resources, financial and otherwise.
Conan O'Brien	, Cory Booker	, Newark	, Urban Issues


You've propably heard the the old mantra about what to look for in real estate. It matters where you locate (or relocate), but it matters for different reasons today than it did even a decade ago. We are sowing the seeds to make sure Terre Haute is prominent on the map for your business.
The Hoosier Jack Mega Site consists of over 10,000 contiguous acres in the sothwestern Vigo County and northeastern Sullivan County. The entire parcel is owned by one entity. The property was a former Black Beauty (Peabody Coal) surface coal mining operation. The property is a combination of reclaimed surface property and undisturbed acreage.
Given the immense size of the Hoosier Jack, depicted is a 2,100 acre subset parcel. It's estimated there should be 1,000 contiguous, undisturbed/buildable acres within this subset, mostly on the west side which is borderd by CSX mainline. A connecting track runs through the center of the subset parcel and is owned by the property owner.
Located within the city proper, this 80-acre greenfield is bordered on two sides with several thousand feet of rail. Adjacent to the Fort Harrison Industrial Park, the site is zoned for M-2 Heavy Industry. The property is available as a design/build construction package.
The 44 acre greenfield site is owned by, and is part of the Terre Haute Regional Airport (HUF). The site completed Duke Energy's Site Readiness Program in partnership with McCullum & Sweeney Consulting.
FAA approval is required prior to building on the site. Access to the property is via U.S. Highway 42 and is 4 miles from Interstate Highway 70.
HUF is the 4th busiest airport in the state for operations with its 9,020 foot runway, which handles the largest military and civilian aircraft. HUF is positioned in a TIF District (Tax Increment Finance). FTZ (Foreign Trade Zone) benefits are available via INzone.


A De Montfort University Leicester (DMU) graduate who has recently been shortlisted for a well-regarded international prize has seen those images published in her first book today.
Mandy Barker graduated from DMU with a distinction in Photography MA in 2011 and has just been nominated for the much-heralded Prix Pictet award. Her first book Beyond Drifting: Imperfectly Known Animals is published by Overlapse.
The images within have been shortlisted for the 100,000 Swiss-franc Prix award and Mandy is just the seventh Brit to make the shortlist in its nine-year history.
Mandy's 104-page book features 59 colour photographs and illustrations in a beautifully-designed hardcover with hand-finished touches, made to look like an antique science book.
A dummy version of the book was first shown with the help of the East Wing Gallery, Dubai, at an exhibition in Amsterdam last September.
She explained: "It received a lot of interest there so it made sense to publish it. Because the book is a replica of an antique science book from the 1800s, a lot of consideration went into the aesthetics in terms of the paper and finishing.
For several years Mandy has been using her photography to raise awareness about plastic pollution in the world's oceans to expose the harm it is causing to marine life and it was while at DMU that Mandy first began to photograph plastic debris.
She said: "The Beyond Drifting: Imperfectly Known Animals series highlights scientific research that plankton are ingesting microplastic particles, mistaking them for food. At the base of the food chain, plankton are a crucial source of sustenance for larger creatures. The harmful impact of plastic on marine and human life is a vital concern.
Mandy's images hark back to the pioneering observations made by marine biologist John Vaughan Thompson in Ireland in the 1800s and show scavenged plastic debris in a form that mimic samples under a microscope.
Mandy gave the 'specimens' new scientific names with the word 'plastic' hidden in the title. The work represents the degradation of plastic particles in the natural environment by echoing earlier scientific discoveries when organisms were free from contamination.
Mandy recovered the plastic objects from the same Cork Harbour in Cobh, off Ireland's south coast, where Thompson made his discoveries.
She first started to photograph plastic debris when studying at DMU for her MA. Students were briefed to produce a project with a technique and subject matter that they had not attempted before.
"It pushed me out of my comfort zone and made me try harder to make something new work, rather than be complacent with a technique I was happy with. The result was my first series using marine plastic debris," said Mandy.
She will be signing copies of her new book at major international photography fair Photo London at Somerset House next month. She will be at booth C-2 in the central London venue's East Wing Gallery on the weekend of May 20-21.
An artist's edition of the book contained in a hand-made box replete with a replica sketchbook for the series, two limited-edition signed prints and a microscope slide sample of micro-plastic from the shoreline of Cobh, Ireland, will also be released at Photo London.
Mandy will go on to promote the book at the Rencontres d'Arles photo festival in France in July and at the Paris Photo exhibition at the Grand Palais on the Champs-Elysées this November.
The Prix Pictet award is by nomination-only with 300 selectors worldwide picking just 12 people each year from some 700 photographers for its final shortlist. The winner will be announced by former UN Secretary General Kofi Annan at the V&A Museum in London this Thursday (4 May).
Mandy's images are also being exhibited at the V&A Museum from 5 May until 28 May, and at The Sirius Arts Centre, Cork, Ireland, from 27 May until 2 July.


Saronic Gulf, Greece - Information - Find the information you need.
Among the magnificent island clusters that are outspread all over the Greek seas and embellish the country in a bedazzling manner are the small but beautiful Saronic Islands. They are considered to be an ideal resort for long-term vacations as well as for a weekend escapade.
Some of the very prettiest islands in Greece, they offer clear watered harbour towns, which wind up through pine forests to medieval monasteries. Many of them have a buzzing nightlife, but they're not party islands, per se, which leaves space for a civilized, laid back approach to vacationing in Greece.
The cluster of the Saronic Islands is comprised of the following exquisite islands: Angistri, Salamina, Aegina, Hydra, Poros and Spetses.
The verdant island of Angistri is small but offers crystal clear beaches. The far side of the island is mostly agricultural and in the village of Limineria, the residents devote themselves mostly to farming and fishing.
The historical island of Salamina is the closest to the mainland. Here one can find reasonably sandy beaches at Iliakti, Kanakia, Moulki and Peristeria.
Aegina is relatively flat. Its beautiful villages are dotted among the pine trees and lush green pistachio orchards, which it is famous for along with its ceramics. Here you can see the Temple of Aphaia and Perdika, a pretty fishing village with a good sandy beach.
Hydra, known for its naval tradition is a barren, rocky, car-free island (only donkeys are permitted for transportation). Built into the hill overlooking the harbour, it is a labyrinth of steep cobblestone streets, filled with chic bars, restaurants and art galleries. It is popular with artists and jet setters, primarily for its beauty.
Poros is a thickly wooded island separated from the Peloponnese by a very narrow channel. It is known for its white buildings with blue woodwork, typical of Greek island architecture. Here lie the remains of Poseidon's Sanctuary. The best sand beaches lie at Askeli and Neorio.
Spetses has long been a popular holiday retreat because of its beaches and beautiful pinewoods. Cars are forbidden here to, except to residents. The best beaches lie at Agia Anangiri and Agia Pasaskevi. Vrelos and Kaiki Beach offer many water sports for you to enjoy.
While on the islands, don't miss out on seeing the village of Paleochora (formerly known as the 'town of 300 churches', whereas today there only exists about 15.), hiking to the deserted Episkopi Monastery, scuba diving and hang-gliding, swimming in deserted coves, touring the enormous lemon grove of Lemonodassos and watching US/UK films at the Diana open-air cinema. There are also many opportunities to enjoy sailing, wind and kite surfing, parasailing, paddleboats and canoes.
Of course, whichever island you choose, there will be enough choices as to dining experiences, with the numerous bars, cafes, restaurants and clubs and lodging accommodations in the many inns, apartments and the two, three and four-star hotels.
So come, relax and have a vacation of fun-in-the-sun in the little but beautiful Saronic Islands. You'll bring home with you a lifetime full of great memories to relive and share.
Aegina is a very seductive, picturesque island with idyllic landscapes. It is an ideal place for your vacation, during all seasons. Many visitors also choose Aegina for a brief escape on their weekends. It definitely offers wonderful sandy beaches and amazing natural beauty for your pleasure.
The first thing you will notice as you come into port are beautiful fishing boats, brightly colored yellow and pink facade houses, blue domed churches, stone paved alleys and the peculiar white washed Church of Agios Nikolaos.
Greece connoisseurs swarm to this most beautiful and fascinating island, which was exempted so far from the mass tourism. Poros, meaning passage consists of two volcanic islands, Sferia, a small rocky island and Kalavria, a larger and more of a lush green island, offering a nice coastline. A bridge connects the two islands. The climate is mostly dry during the summer, with cool sea breezes blowing across these little paradise islands. Here you will find all the beaches and most of the hotels in Poros.
Among those relatively unspoiled and unknown places in the Aegean Sea, the most extraordinary of all is certainly the fresh, well-wooded little holiday resort named Spetses.


text:
Q: SCALA: How I can initiate another future call within callback from future My scenario is, I have multiple API's call to be made and each of them will require to use data from previous call.
Now let's suppose I made a API call with future, and return response of the first call, I am not able to call next API from within Oncomplete of first call.

A: You can link Futures with flatMap function
def firstApiCall(): Future[FirstRes]

def secondApiCall(firstRes: FirstRes): Future[SecondRes]

def combinedCall()(implicit ec: ExecutionContext): Future[SecondRes] = firstApiCall.flatMap(res => secondApiCall(res))

A: You could use flatMap or the cleaner alternative to sequencing a bunch of of futures, which is to use the for yield syntax. It's just compile time sugar that will internally transform itself into flatMap and map and withFilter method calls, but it's generally cleaner and easier to read.
import scala.concurrent.ExecutionContext.Implicits.global

for {
  first <- firstApiCall()
  second <- secondApiCall(first)
} yield second


Life from the Dead is an in-depth study of the incredible endurance of the Jewish people in history despite ongoing systematic and unrelenting efforts to effect their genocide. The survival of the Jewish people is not, however, merely a testimony to their own resiliency or ingenuity. It is a testimony to the utter faithfulness of their God to maintain the integrity of the covenant he made with Abraham, Isaac, and Jacob.
The God of Israel is the ruler over death and life. As such, he can heal the sick and restore the terminally ill to life, and in the end he will keep faith with the righteous who are in the dust of the earth by bringing them forth to life from the dead in the resurrection. Life from the Dead will build your faith in God's power to triumph over death and to bring abundant life to all those who put their trust in him.


Local school children have had the chance to experience life as a World War II European refugee, learning what it was like to live on restricted rations and how the British learned to be creative with limited materials.
This unusual workshop is being offered to local schools by Splatter Make, which seeks to teach people traditional skills of growing, cooking, mending and making that used to be handed down to generations but are now being lost.
The whole event is designed an immersive drama experience and is based on Judith's Kerr's 1971 book, 'When Hitler Stole Pink Rabbit'. This is a semi-autobiographical novel telling the tale of a young Jewish girl and her family fleeing Nazi persecution.
The children came dressed as refugees, bringing with them a favourite toy, as did many children from Eastern Europe after fleeing Nazi persecution. They were met at the station by Splatter Make staff who accompanied them to the company's Beckenham premises.
Activities during the day included learning more about what it was like to be a refugee child, rationing and wartime fashion.
On 'The Kitchen Front,' Donna taught them about grow your own, rations and using leftovers. This was followed by a group carrot cookie making session.
Jane explained and demonstrated how to extend the life of garments through 'make do and mend' techniques, before letting have a go themselves.
Splatter Make founder Amanda Litster says although this is a fascinating way to learn more about our immediate past, the workshop is more than just a history lesson. "The workshop is cross curricular to build on some of the subjects the children learn in school but, as importantly, it reflects the Splatter Make ethos – to teach the skills that would have been second nature to those who lived through the war.
To book a workshop or for further information, contact Splatter Make on 020 3326 1160 or email: info@splattermake.co.uk.