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Home » About GaBI » News » A strategic approach to increase uptake of biosimilars in Spain
A strategic approach to increase uptake of biosimilars in Spain
Ainhoa Aranguren Oyarzábal and colleagues from the Madrid Health Service (MHS), Spain, describe the strategic approach that has been introduced in Spain to try and improve uptake of biosimilars in the country [1].
The Assistance Direction of Pharmaceutical Management (ADPM), which comes under the General Authority of Healthcare Coordination, is the department of MHS in charge of making decisions about the region's strategic plans regarding drugs and medical devices.
In 2010, the ADPM established a strategic approach to try and improve the uptake of biosimilars in the region. The introduction of this approach meant that since this time all biosimilars use has been monitored through the evaluation of hospital drug procurements.
In 2014, in order to implement the strategic approach for biosimilars, the MHS signed a Contract Plan with the hospitals in the region. This Contract Plan contained indicators and objectives related to different issues and included incentives for compliance with the indicators. Pharmacy related indicators represent about 15% of all the indicators in the Contract Plan. An indicator for the tracking of biosimilars of somatropin, erythropoietin and filgrastim, defined as %Biosimilar Drugs Cost Value, was included in the 2014 Contract Plan.
The method used to work out this indicator was:
%Biosimilar Drugs Cost Value = Purchase cost of biosimilars of somatropin, erythropoietin or filgrastim/Purchase cost of all brands of somatropin, all brands of erythropoiesis stimulating agents or all brands of colony-stimulating factors.
Three variables were considered during the definition of this indicator:
• All three available drugs at that moment (somatropin, erythropoietin and filgrastim) should be monitored in a single merged indicator. This allowed each hospital to choose the most suitable group of drugs to work on.
• Denominator of the indicator: not only biosimilars and their corresponding originator drugs were considered in the denominator, but also the other drugs within the same ATC code group. This meant that filgrastim, lenograstim and pegfilgrastim would be included for the example of filgrastim. This approach implies equivalence among different drugs with similar uses in the same ATC code and measures the impact of the biosimilar with respect to the whole ATC group.
• The cost of drug purchase was selected as the measured value (both in the numerator and denominator) to evaluate the economic impact. Price (including discounts) was chosen in 2014, but was changed for the following years to the official laboratory price (price without discounts). This decision was made on the one hand to minimize the bias when high discounts for originator drugs could be obtained, and on the other hand to minimize the resulting distortion when comparing different hospitals with different discounts.
A second indicator, defined as the percentage of patients on infliximab biosimilar, was created at the end of 2014 in order to evaluate the introduction of biosimilar infliximab. It was a follow-up indicator and was not included in the Contract Plan in 2015. It was designed to study two scenarios:
2.1. Percentage of new patients starting on (biosimilar) infliximab in a set period of time out of all new patients starting on infliximab (originator or biosimilar) in the same period of time.
2.2. Percentage of new patients starting on (biosimilar) infliximab in a set period of time out of all patients with a prescription for infliximab (originator or biosimilar) in the same period of time.
These indicators were measured by making the following decisions:
• Infliximab biosimilar monitoring should be measured with an independent indicator: biosimilar infliximab introduction measured as the first indicator (%Biosimilar Drugs Cost Value) would be imperceptible, as the ATC code group for infliximab encompasses many drugs with a very high economic impact.
• The measure value: as the economic impact of biosimilar infliximab could be difficult to appreciate in hospitals with a high infliximab charge, the number of patients on infliximab was selected as the measured value for this indicator.
• The two indicators were designed in order to track two different approaches. The first to track the scenarios where the biosimilar is used in new patients starting on infliximab, and the second to track the switch from the originator to the biosimilar in patients with good control of the disease. Which approach was used was a policy decision made at each hospital.
After a whole year (2015) of monitoring of both infliximab indicators, a decision was made to include the first indicator in the current 2016 Contract Plan. This plan therefore includes both the %Biosimilar Drugs Cost Value and the percentage of patients on infliximab biosimilar (new patients).
This article is prepared based on the paper entitled 'Best practice to improve biosimilars uptake: the experience of Madrid, Spain' by Aranguren Oyarzábal A, López Centeno B, Alonso Castro V, Calvo Alcántara MJ, Cruz Martos E, Assistance Direction of Pharmaceutical Management, Madrid Health Service, Spain
Readers interested to learn more about market uptake of biosimilars are invited to visit www.gabi-journal.net to view the following manuscript published in GaBI Journal:
Product naming, pricing, and market uptake of biosimilars
Readers interested in contributing a research or perspective paper to GaBI Journal – an independent, peer reviewed academic journal – please send us your submission here.
Improvement in uptake of biosimilars in Spain
Uptake of biosimilars increasing in Spain
Approaches to increase uptake of biosimilars in Spain
Improving uptake of biosimilars in Spain
1. Derbyshire M. Improving biosimilars uptake: experience gained in Madrid, Spain. Generics and Biosimilars Initiative Journal (GaBI Journal). 2016; Epub ahead of print
Source: www.gabionline.net
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Important Evidence: Antioxidants Do Not Slow Aging
Antioxidants slow aging, repeated faithfully without question is not holding up well in numerous studies. Antioxidants may actually cause aging, or trouble, in some cases.
"The free radical theory has filled a knowledge vacuum for over 50 years now, but it does not stand up to evidence" said Dr. David Gems to BBC News on December 1, 2008. David Gems breakthrough study was written up in Medical News Today, also on December 1, 2008. Google search does not show it appearing in other mainstream media as one would expect considerable attention to this work. The study then became the foundation for 'The Myth of Antioxidants" by Melinda Wenner Moyer in Scientific American, February 2013–five years later.
What is the free radical theory and hypothesis?
According Wikipedia:
The free radical theory of aging (FRTA) states that organisms age because cells accumulate free radical damage over time. A free radical is any atom or molecule that has a single unpaired electron in an outer shell…. (Electrons normally exist in pairs.) Most biologically relevant free radicals are highly reactive…. For most biological structures, free radical damage is closely associated with oxidative damage. Antioxidants are reducing agents, and limit oxidative damage to biological structures by passivating them from free radicals.
The man who came up with this theory in the 1950s was a chemist by the name of David Denham. It is because of this hypothesis that we are told by our doctors, nutritionists, the media, and advertisements about the wonders of antioxidants taken as multivitamins. They are available to us in supplements, in fortified foods, in cosmetics, in soaps and hair products. We spend billions on these products.
Then came David Gems' experiment and he was trying to prove the FRTA hypothesis. Much to his surprise, his experiment challenged it and did not support it. Thinking he had made an error he asked a colleague to repeat the experiment. The result was the same.
David Gems Experiment: Gems uses a certain type of round worm in his aging studies. Certain enzymes in these worms are the organism's naturally produced antioxidants. Gems bio-engineered the worms so they no longer produced these enzymes, no antioxidants. As expected, without antioxidants the free radical levels in the worms shot up. Now according to FRTA, the worms should have died prematurely. But they did not die prematurely.
Gems is Professor of Biogerontology, Department of Ageing (spelled the British way), at the University College of London. The link to his profile will lead to some of his papers for further reading.
Arlan Richardson Experiments: This information was gleaned from the Scientific American article. In Richardson's experiments, 18 strains of mice were genetically engineered in two ways–some to produce more than normal levels of certain antioxidant enzymes and some to produce less than normal levels. According to FRTA, the group with higher levels of antioxidants would outlive those with lower levels. But the lifespan curves demonstrated no difference in the life spans.
Richardson is the Founding Director of the Barshop Institute; Professor of Cellular & Structural Biology at the University of Texas Health Science Center, Cellular & Structural Biology and the Barshop Institute. The link to his name will take readers to further links to a PBS interview with Richardson and the lecture "Can we slow down aging, should we?"
Rochelle Buffenstein experiments: Again this is sourced from the Scientific American article. Buffenstein's research demonstrates that the naked mole rats have lower levels of natural antioxidants than similar sized mice. Consequently they have more oxidative damage, and at an earlier age, than mice. But they live eight to 10 times longer, virtually disease free.
Buffenstein is a professor at the University of Texas Health Science Center and her work can be viewed via the link.
Free radicals clearly accumulate in the aging process. They may not be the cause, but the byproduct, of aging. In small amounts, they may possibly boost the body's ability to repair cellular damage. However, in large amounts they can create damage and lead to various diseases.
Interestingly, Moyer writes about a study comparing a group that exercised and took antioxidants with a group that exercised but used no vitamins. Paradoxically, exercise produces free radicals but is beneficial. The group that did not take any supplements was healthier and showed fewer indications of developing type 2 diabetes than the group that took antioxidant supplements.
There is clearly a lot more to learn about aging and antioxidants. But do we have to take all these antioxidants? Beta carotene and retinol may actually increase the odds of developing lung cancer and heart disease (see article link for charts). The article concludes that taking antioxidants may do us more harm than good. It must be noted though there is a difference in the way an organism may react to naturally found antioxidants in food versus manufactured antioxidant supplements.
For more, please refer to the Scientific American article (link above) and visit ScientificAmerican.com/feb2013/aging
National Institute of Aging concludes:
Antioxidants protect the body from the harmful effects of by-products known as free radicals, made normally when the body changes oxygen and food into energy. The discovery of antioxidants raised hopes that people could slow aging simply by adding them to the diet. So far, studies of antioxidant-laden foods and supplements in humans have yielded little support for this conclusion. Further research, including large-scale epidemiological studies, might clarify whether dietary antioxidants can help people live longer, healthier lives. For now, although the effectiveness of dietary antioxidant supplementation remains controversial, there is positive evidence for the health benefits of fruits and vegetables.
http://www.nia.nih.gov/health/publication/can-we-prevent-aging
Published by MM
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antioxidant supplements harmful, david gems, free radical theory, free radicals and aging, research on aging and free radicals
Dark Night of The Soul, Shivaratri, And Yoga Illuminated
Politics And Business Connect To Being in Flow CD? Yes.

redpajama_set_name: RedPajamaCommonCrawl


Germans and Americans are both low-context communicators, which means they both convey meaning explicitly through words. In a business context, when an American is in a position of higher power (such as a customer or a boss), communication can often be very direct, even brusque (I've been waiting for an opportunity to use "brusque". Score!) This does not have to be the case, of course, but does tend to catch Germans by surprise when it happens since Americans have a reputation for effusiveness, optimism and positivity.
Which brings us to American communication style on a personal- or equal-footing business level. Here, we roll on more of a "feel good" basis, using smiles, agreement, compliments and "can do-isms". Underpinning this style is the belief that motivation flows from mutual positivity. The fancy-pants academic word for this is called "reciprocity" (this study takes a deep dive into the details of the communication style differences of German and American teams). In fact, communication tools such as criticizing, complaining and using negative sentence constructions are received as unfriendly and counterproductive.
In problem-solving communications, even spending time at length in identifying and analyzing problems at their deepest roots can get a German working in an American team branded as too negative. The same study linked above showed that American teams spend comparatively little time on problem analysis, instead jumping much faster to the business of finding solutions, as this is a more positive, forward-looking activity. Anecdotally, a client who works in the IT-area of his company told me that whereas German team members tend to work to solve a problem ("ein Problem loesen"), the American team members often want to "remove" the problem ("ein Problem beseitigen"). The subtle difference implied in the German terms is the difference between solving a problem in a more drawn-out, complex—but thus more permanent—manner and "spot cleaning" a problem so that it is quickly set aside, or solved on a more temporary basis.
Another part of the unwritten rules of communication is that praise and thanks are doled out more frequently among Americans than Germans. Every time I get to this part in my trainings, someone inevitably cringes, mainly because lots of folks here live by the credo "Nichts gesagt ist genug gelobt!" (roughly translated, "If I haven't said anything, consider yourself praised!"). It is, of course, a bit of an exaggeration, but not in comparison to American communication style!
Germans, you really are going to have to go Zen with giving American colleagues (especially those reporting to you) a semi-regular dose of the verbal feel-goods. Some of this has to do with our communication style, some of it has to do with a generally lower level of job security in the USA that leaves folks needing a higher level of assurance that they are appreciated and doing good work. Do not be insincere; just lob a few simple praise goodies someone's way when they have accomplished something positive, even if it that something is reasonably expected from their job duties. Bonus points: say it with a smile.
-While you can spend time gnawing at the deepest root of a problem in the privacy of your own cubicle, in the presence of colleagues, come in with your most well-thought-out but quickly (-ish) implemented solutions. If you can package these to at least sound new or innovative, so much the better.
-When your colleagues offer "out there" solutions, try to keep your mind open, and in good German form, think of ways to make out-of-the-box solutions implementable. Somewhere in the middle is always a good place to meet.
-Become friends with "great!", "thanks!" "nice job!", "really appreciate it!" and, if you're really feeling wild and crazy, "awesome!".
So, that's the scoop for today. In short, keep it positive, forward-looking, and say it with a smile.
Really appreciate your attention…it was great (awesome!) blogging to you again!
If a business relationship with Americans is on your horizon, book an intercultural training to get up to speed on communication style, among other aspects of business with the USA.


What's the total number of tracks at which you have seen race? Permanent dirt and pavement ovals count. Paved road courses count. Drag strips count. I don't count kart tracks. Demolition derby doesn't count, but enduros do. (I enjoyed a garden tractor race at Richland County Fairground, but the track doesn't count.) If you went to Mansfield when it was paved, you can count it again now that it is back to dirt. These are my guidelines. Yours may be different and that is perfectly okay.
132 tracks in 20 states, from 1955 to the present. If there is more than one track on the grounds of a track, or if a dirt track gets paved or altered in any way, I only count that track once. I do count indoor facilities providing a legitimate auto race is held, such as full sized midgets at Fort Wayne, etc.
21 race tracks across OH, IN, PA, MI, KY, NC, FL & OK. 36 tracks if I count kart tracks/races. Hoping to add Waynesfield and Atomic to the list this year.
I come up with 40 tracks that I have attended.
I have been to 21 total. That includes one dragway, mostly dirt and a few asphalt and indoors. It also includes tracks that have reconfigured. I have seen races at I-96 on the old 1/2 and 1/4 plus the "new" 3/8. I believe rules state you count that multiple times.
Most have been in Michigan or Indiana. I have only ventured into Ohio a few times but that will change soon. I have a young family so I try to keep travel within 2 hours of my house.
21 total for me. 1 dragstrip, 6 Nascar tracks, 2 asphalt short tracks (1 no longer exists, RIP Columbus motor speedway) 12 dirt tracks mostly in Ohio. I actually have more on my bucket list than ones that I have been to.
53 across 13 states I think.
Muddy used the phrase "a legitimate auto race". If it's not a legitimate auto race (like garden tractors), the track doesn't count. Muddy is correct counting indoor tracks like Ft. Wayne. I don't count motocross, some of you might. I do count the dirt oval at The Allen County Fairground where I saw an AMA flat track motorcycle race.
15 total that I know of. 12 dirt all in OH or Eastern Indiana (Attica, Fremont, Wayne County, Millstream, Mansfield, Lawrenceburg, Route 44, Atomic, Eldora, Portsmouth, Route 44, and Montpelier in that order.) 2 Paved ovals in old Mansfield and Martinsville. 1 drag strip that I'm old enough to recall in Norwalk.
2 nascar in Pocono - Darlington, 1 drag strip, 2 road course tracks in Nelsons ledges- mid ohio, 1 asphalt Midvale, 14 dirt tracks atomic,mansfield,Sharon,attica,Waynesfield,fremont ,wcs,hilltop,muskinghum,Deerfield,lernerville,merc er,eriez, and PPMS.
Doing a quick count, I came up with at least 84 tracks. Probably missed one or two but for the most part that is it. I will pick up a few new ones along the way in the coming years. I've enjoyed them all.
22 tracks across 5 states. All ovals, mix of dirt and asphalt. I counted Bristol as 2 tracks. Went to the spring Cup race and dirt race in June, back in 2000.
If you count dragstrips also I'm at 84 in 10 states. I try to add at least one new track every year. This year I added LaSalle and plan on hitting Smokey Mountain in a couple weeks.


When I do all the talking, I can't hear God! That's right. You heard me right. Do you ever have that problem? Prayer isn't just talking. It's listening, too.
Sometimes, in my eagerness to write, I rush ahead of God. When I don't wait on Him, I make mistakes – not horrible mistakes, but my writing lacks something.
In other words, I can't wait. So I write in my own strength, depending on my own abilities. That is not what God wants from me.
How do I know that I rushed ahead of God? Because I realize later that I ignored the still small voice. That's easy to do. We hear the whisper of God's Spirit, but do not stop long enough to consider it. We cannot wait. We have to plow on.
I pray that God will teach me to wait and to listen; and to know the difference between working in my own strength or wholly depending on His.
Next postThink You Can't Hang On?
Thank you for telling me that! I need encouragement, too! God bless you as you share what God has done for you.
You are very welcome. I'm glad it spoke to you. God bless you Christy!
Thank you for sharing your thoughts! Blessings!
I needed to hear this. I do this, not wait on God because of my eagerness. Thank you for this. You have helped me to see clearer.
Wow. Yeah, I needed this too. Thank you so much for sharing!!!
Callie, Thank you for your encouragement! Blessings!


If you travel a lot for business, you probably know this all too well and have your own set of tips to avoid overly wrinkly outfits — pants especially. I've tried rolling my pants, using a travel iron, and the old hang-while-you-shower trick.
My favourite trick of all however is to buy trousers in smart fabrics. We've come a long way in terms of "performance" fabrics and more suiting companies are using sportswear technology and more sportswear companies are designing for everyday life. To help you out, here are my five top brands for wrinkle-resistant trousers, in black of course.
I love Everlane trousers because they are the perfect wool blend. Naturally, I was intrigued when they launched a special version of their trousers in a wrinkle-resistant fabric. The GoWeave™ yarn is "tightly spun in Italy, creating a wool twill that is wrinkle-resistant and astonishingly smooth". Not bad for winter jet-setting.
These pants are nothing special, but what I love about some of the low-end brands like Zara and H&M is, believe it or not, their use of polyester. Viscose is a drapey fabric that has more give as well as being easy to toss in the wash.
A modern (or vintage, however you want to see it) take on a classic trouser. The slightly oversized pleating and cropped ankle are super cool and breezy, while the fabric is working overtime. Kit and Ace works with wonderful cashmere blends and have designed their own travel-optimized Ontace™ Suiting with 84% wool, 6% spandex, 5% cashmere, 5% silk.
Trust Lululemon to make a pair of track pants look good. If you're not heading straight to a boardroom from the plane, but still want to look smart, try this Trek trouser made of water repellant "urbanite twill".
Another synthetic pick with a composition of 82% triacetate and 18% polyester. These pants are great for long-haul flights with their elastic waistband and slight give in the leg.


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Do you ever feel like the church is just too big to get to know anyone? That's exactly why we encourage everyone to explore our Grouplife opportunities!
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A missionary who found the door opened to take the gospel to China. The spiritual successor to Francis Xavier. In 1567 a small island off the coast of China, Macao became a Portuguese colony. For years, however, the entrance to China seemed impossible. The ruling Ming dynasty had no interest in contacts with the outside world. They considered the Chinese as the givers of culture, not the receivers. Confucianism was dominant. In 1579 Allessandro Valignani, a leader of the Jesuits in the Orient, called Ricci to Macao and placed the burden of China upon his shoulders. He settled in Macao to learn the Chinese language and customs. In 1583 he secured permission to settle in Chaoch'ing, the provincial capital. With their traditional respect for the scholar, the Chinese responded to a man who dressed in the garb of a Mandarin, spoke their language, and was able to open to them new fields of learning. Step by step he moved toward the capital of the empire. In 1600 he gained permission to enter Peking itself. Upon gaining favor with the Chinese emperor with his gifts of clocks and his expertise in keeping them in good condition, he remained in the capital for ten years as an astronomer and mathematician. Under his guidance the Jesuit mission in Peking took root and flourished. At the time of Ricci's death in 1610, the church numbered 2000.


is an attorney at law in Lynchburg Virginia specializing in family and collaborative law. She has over thirty years of experience as a lawyer and is well-versed in family law, collaborative law and mediation.
The collaborative divorce process is an alternative to doing battle in court. A team of counselors, lawyers, child and financial specialists help the parties find solutions to their disputes. Everyone agrees not to go to court. Information is shared by the parties and negotiations are frank and open. Collaboration is a quicker, more flexible and generally less expensive way to get a divorce. By working out solutions as part of a team, the parties get better results and spare children the trauma of battle. The parties are also more inclined to accept and carry out the terms of a collaborative agreement than to abide by a court-imposed solution.


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Home80'sBrian Cox Is A Better Hannibal Than Anthony Hopkins. A Manhunter Review
Brian Cox Is A Better Hannibal Than Anthony Hopkins. A Manhunter Review
Film Score: ⭐⭐
Released by De Laurentiis Entertainment Group (D.E.G.)
Starring: William Peterson, Tom Noonan, Joan Allen, and Brian Cox
Written by Michael Mann
Directed by Michael Mann
Rated R (Language and violence)
I am not the biggest Michael Mann fan. I have seen most of his films, but I only like a handful of them. Suffice it to say, but Manhunter is not one of them. The film starts out promising. In fact the first hour of the film is really good. We are introduced to the characters in a nice way, we believe there interactions, and we care about what they do and the consequences of their actions. We are given a step by step look at how they go about figuring out various things that happen and it is exciting. This attention to detail would also come up in To Live and Die in L.A., the film that proceeded this one for star William Petersen and has a similar look and feel. But where To Live and Die in L.A. was exciting all the way through, Manhunter stopped being exciting about halfway through.
The story is pretty straight forward. Will Graham is an FBI called back into service after two murders have been linked together. Graham is an expert profiler, having brought down the ruthless and cunning Hannibal Lecktor (Brian Cox) and lost his mind in the process. Graham takes the case so long as he isn't linked to the case. Enter Freddy Lounds (Stephen Lang), a reporter for a shitty tabloid The National Tattler, who outs Graham's involvement with the case.
All of this is great set up and Mann handles it very well. Graham goes to see Lecktor for help with the case. The scene between the two is one of the best scenes in the film. Petersen and Cox are clearly at the top of their game and, while the scene is short, it makes an impression on the audience that isn't lost.
After the meeting, Lecktor is found to be hiding a letter written by the killer and tucked away in a book. Here is where Mann really shines as a director. His attention to this letter is a main focus for an extended period of time. He takes us through the steps that the FBI takes in uncovering the mysteries of the letter. If you have seen this film then you know how exciting this portion of the film is. I was really intrigued by these scenes even though I had seen 2002's Red Dragon which is adapted from the same novel.
While the first half of the film is loaded with tension and excitement, the same can not be said about the back half. We are introduced to the film's killer, Francis Dollarhyde (Tom Noonan). Dollarhyde is supposed to be a scary guy, but his introduction, when he is wearing the stocking on his head, made me laugh very hard. From here until the end of the film, there are so many scenes that are cringeworthy, and not in a good way, that I was having a hard time keeping my attention on the film.
We are also introduced to Reba (Joan Allen) who is a coworker of Dollarhyde. He asks her out and he takes her to the zoo where is pets a tiger. After that she has sex with him and he falls for her. I like Allen. She is really good here, but she is given so little to work with that we wonder why she was included in the film at all.
This is a huge problem I had with the film. The focus of the film is on Graham so Dollarhyde is pushed to the background. Why isn't his part in the film bigger? We spend the first hour of the film learning about how bad this guy is and then when we get to him, we realize that we were set up for failure. The Dollarhyde we are told about doesn't even come close to the one we are given. And don't take this as a slight against Tom Noonan, who is a great actor and does what he can with the role, but I did not find this film's Dollarhyde scary at all.
I did find this film's Lecktor a lot scarier in this film than Anthony Hopkins' Oscar winning Lector. Here Cox is so sure of the character that we don't even realize that he is a really bad guy until later in the film. He is menacing and kind and playful and evil all in the same scene. He makes a big impression and would have liked to have seen him in the role again.
Aside from the performances, which are really good, I found the look of the film to be very pleasing. Director of Photography Dante Spinotti really shines here. I found the first scenes of the film to be gorgeous, with a shot of the ocean as the sun is setting to be my favorite. There are a lot of shots in this film that are magnificent and this is where the film excels. The film looks better than it plays.
There is something that bothered me. Throughout the film, Graham is seen talking to himself. Most of the time this is ok as he is talking into a tape recorder or he is watching the videos of the victims, trying to figure out how Dollarhyde chose these families. Then there is one or two scenes where is looking out a window and he is posturing. "I'll get you bad guy. It is just a matter of time, blah blah blah." I laughed during these scenes because they are so out of place. It is like he is Dr. Claw from Inspector Gadget. "Next time Gadget. Next tiiiimmmme!" Just brought a smile to my face thinking that Michael Mann wrote that dialogue and thought it was good enough to put into the film.
The action scene that ends the film is another thing I had a problem with. It is so boring and shot so poorly that I swear there are shots in this scene where no one is in the shot. Mann would go on to direct one of the best shoot out scenes of all time with Heat (1995) so it made me wonder if I had seen it wrongly. Nope, there is a shot or two where there is nothing happening. Why is that shot there? Also, there are some jump cuts that seem really out of place. I don't know. The scene is so short that it doesn't even matter.
Manhunter is not a very good film. The performances are really good, especially by Brian Cox, but they don't save the film. If Mann had rewritten the second half to be as good as the first half, we might have had a good film on our hands. As it stands, though, Manhunter is half a good film.
80's Bad Based on a Book Cult Classic Thriller


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The Uprising has fallen
>> The Uprising has fallen
It was fun while it lasted!
As the 1st of May passes, Blizzard sticks to their promise and removes the Uprising event from Overwatch.
For those of you who happened to be on holiday from 11th of April till today a few words of introduction. Uprising was a seasonal event, in which players could for the very first time dive into the lore of Overwatch.
The world of Overwatch is beyond the shadow of a doubt one of the best-written universes in gaming. Sadly, many people don't know anything related to it as the game does not ram it in your face by any means. For them, Overwatch is all about fun & shooting, with some lore-related flavor texts here and there. But by no means is that wrong! They bought a game, a quick, fast-paced shooter to kill the boredom during these pesky winter evenings! If they wanted to experience a deep and touching storytelling, they would have chosen Planescape: Torment (can you think of a more classical example of a top-notch narrative in a game?) right away and wouldn't bother with Overwatch at all.
Until the Uprising, the lore was accessible only through comics, stories, and animations (the quality of which, by the way, matches Pixar movies). There was no actual way of replaying the events that have shaped the Overwatch's world.
The Uprising scenario allowed players to replay Tracer's first mission. In this story, Torbjörn, Reinhardt, and Mercy had to defend King's Row from swarms of attacking omnics. In a Left 4 Dead-style PvE Brawl, the players could finally take part in canon events and become heroes of the Overwatch lore.
To keep it fun, Blizzard enabled an all-hero mode allowing to use all characters. The event rewarded participants with seasonal loot boxes containing unique content, unobtainable elsewhere.
In total 114 new items were made available. Needless to say, newer players will look jealously upon veterans equipped with them. Special mention goes to Blackwatch McCree and Combat Medic Ziegler Mercy – these two skins look so well that it will be hard for Blizzard to release something better (these outfits come with Legendary quality; there are 6 other Legendary skins and 2 Epic outfits).
Blizzard stated that more lore-related events are to come, however, as of yet there are no plans to introduce a story mode into the game.
I find this quite sad.
There is so much story that needs to be told.
 May 2, 2017


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text:
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Thank you all for your input on what you would like to read. I promise to always deliver what my audience wants because you all are the reason I write! This week's post includes tips for smoothly preparing for Speech-Language Pathology Graduate School. This post is written from the angle that you are currently an undergraduate student majoring in Communication Sciences and Disorders (CSD).
You may be asking yourself, "Where the heck do I even start?" This is a question I found that I was constantly asking myself. Graduate school applications may seem like a newly discovered cave. You know you have to go into it, but no one is helping you light the way. Despite feeling alone and lost as you prepare to embark on this journey, let me assure you that I, Morgan Newton, am here for you. I will help you gather your resources (and yourself) to be best prepared.
My first recommendation while you are an undergraduate CSD student is to join the American Speech-Language-Hearing Association, commonly referred to as ASHA. Because you are a student, you will choose the National NSSLHA* Membership option. Becoming a member of this national organization as an undergraduate student gives you access to peer-reviewed journal articles (a great source for any essay), a monthly magazine subscription to the ASHA Journal, member discounts, benefits, and other resources. This may not sound exciting, but I can fully attest to the fact that joining ASHA will help you as an undergraduate student preparing for graduate school. To join, all you have to do is create an account and pay the once a year dues. I know, I know. Dues,,, UGH! No college student wants to pay for anything unless it's coffee or food, but please, hear me out. The dues are $60, and you only pay once a year. You are investing in your future because when you one day become a successful clinician, you will be required to be certified by ASHA, and because you will have been a member of NSSLHA, you will receive a $225 discount. Think of how much coffee and food you can buy for $225! All in all, it is important to be a part of the Communication Sciences and Disorders Community. Also, there is a section on graduate school applications that asks if you have ever attended a convention. Click HERE for the link to join.
This next tip comes easily after you join National NSSLHA. You should 100% attend an ASHA Convention if at all possible. These conventions are a CSD party! You learn a ton of valuable information from the different sessions and presentations, but my favorite aspect of the convention is there is an entire section of the convention devoted to networking with graduate school recruiters. It's like speed dating for graduate school. The recruiter (usually one of the heads of the CSD department) sells the school and you get a chance to sell yourself. Schools from all over the nation are represented so the likelihood of your dream school being in attendance is high. This saves you from having to fly all over the country to the different schools you are thinking of applying to. Be sure to bring a business card to give to the recruiters. I attended in 2016 when the convention was in Philadelphia, Pennsylvania, and the experience changed my life. The 2018 ASHA Convention will be held in Boston, Massachusetts starting November 15th and running through the 17th. Being an ASHA member (the National NSSLHA option) gives you a discount on registration, flights, and hotels. I'm doing everything in my power to attend this year's convention. I hope to see you there! Click HERE for the link to see what the convention is all about.
We are now entering into the nitty gritty roll up your sleeves kind of tips. I know you have heard it before, but I cannot stress to you the importance of striving for the highest GPA you can reach. I know there are some tough courses and some even tougher professors, but do the best that you can. I find that some students spend more time complaining about professors than they do studying. Change your mindset to a positive one, and prove to yourself that you are capable of overcoming any obstacle (even your grumpy professor) that comes your way. If you need study tips or help, reach out to me. I have been in your position before, and I can fully sympathize with you and your feelings.
Thankfully, GPA is not the end all be all when it comes to preparing for graduate school. One of the best pieces of advice I have ever received was to strive to be well-rounded. Graduate schools are not just looking for someone who has an excellent GPA. They want a student that will shine and make their program even better. Join organizations at your university and be involved on campus with activities that relate to CSD. For example, join a volunteer organization that works with people of all ages. You will learn transferable skills that will help you as a graduate student, and the schools know this. There is even a spot on the graduate school application to include volunteer experience. Relatable work experience is also highly recommended. Apply at a Summer camp, day care, nursing home, or any other setting where you would work with a population of people that Speech-Language Pathologists work with. The application also has a section to insert work experience. Reading professional articles helps you become a well-rounded student and allows you to gain a better understanding of the concepts and vocabulary you are learning in the classroom. You can read the ASHA Journal magazines that you receive by being a member. Each month the magazine has a different theme so you will always be reading something new.
These tips are all ways to get started on your preparation for graduate school. Remeber to take a step back, reflect, and visualize where you one day see yourself in the Communication Sciences and Disorders field. This is vital because your reflections and visualizations are what will keep you going on those rough nights and early mornings. I hope these tips help you feel a little more prepared for your journey into the graduate school cave. Remeber, I am here for you and am holding a lantern. You are not alone on this journey. Let's Explore together!


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text:
Q: Sheaves without global sections The line bundle $O(-1)$ on a projective space or $O(-\rho)$ on a flag variety has a property that all its cohomology vanish. Is there a story behind such sheaves?
Here are more precise questions. Let $X$ be a smooth complex projective surface (say, a nice one like Del Pezzo or K3). Does there always exist a coherent locally free sheaf $M$ whose derived global sections vanish? Can one describe all such sheaves? Is there a coarse moduli space of such sheaves?

A: Assume that ${\rm char}=0$. If $X$ is Fano and $\mathcal L$ is an ample invertible sheaf contained in, but not equal to $\omega_X^{-1}$, then $H^i(X,\mathcal L^{-1})=0$ for all $i$. This is Kodaira vanishing for $i\neq \dim X$ and for $n=\dim X$, $H^n(X,\mathcal L^{-1})$ is dual to $H^0(X, \mathcal L\otimes \omega_X)$ which is $0$ by the choice of $\mathcal L$.
I think both of your examples are covered by this.
In general, if $\mathcal L$ is contained in $\omega_X$, then $H^n(X,\mathcal L)\neq 0$, so for a K3 (or more generally if $K_X=0$) negative ample invertible sheaves will not work. It is also relatively easy to see that if ${\rm Pic}\, X = \mathbb Z$, then there are no such invertible sheaves.
Edit:
On the other hand, it is relatively easy to find invertible sheaves with this property on K3's with higher Picard numbers. For instance, let $X$ be a K3 and $L_1, L_2$ two disjoint $(-2)$-curves. This requires the Picard number to be at least $3$, but then it is quite common. For instance, every Kummer has plenty of disjoint $(-2)$-curves. So, let $\mathcal L=\mathcal O_X(L_1-L_2)$. Then $\mathcal L$ has no cohomology for any $i$.
This can be seen the following way: First notice that the sheaf $\mathcal O_X(L_1)$ has a $1$-dimensional $H^0$ since $L_1$ has negative self-intersection, $H^2=0$ since its dual has no $H^0$, and $H^1=0$ by Riemann-Roch. Then in the short exact sequence
$$
0 \to \mathcal L \to \mathcal O_X(L_1) \to \mathcal O_{L_2} \to 0
$$
the two sheaves on the right have the exact same cohomology groups and clearly the induced map on $H^0$ is an isomorphism, so the sheaf on the left cannot have any non-zero cohomology.
Second edit: I just realized that this can be done much simpler: $H^0(X,\mathcal L)=0$ since if it had a non-zero section, that would produce an effective divisor linearly equivalent to $L_1$, but not equal to it. Similarly $h^2(X,\mathcal L^{-1})=h^0(X, \mathcal O_X(L_2-L_1))=0$. Finally, then Riemann-Roch shows that $h^1=0$ as well. This argument has the advantage that it shows that if $L_1,L_2$ intersect, then $h^1\neq 0$.
Using similar ideas one can make up lots of invertible sheaves on K3 surfaces with this property.

A: On a K3-surface if a line bundle $\mathcal L$ has vanishing cohomology, then
$\mathcal L^2=-4$ by the Riemann-Roch formula. Conversely, if $\mathcal L^2=-4$
and neither $\mathcal L$ nor its inverse has global sections, then also the
first cohomology vanishes.
If $X$ is a projective K3-surface with $\mathrm{Pic}(X)=\mathbb Z$, then
$\mathcal L^2\geq0$ for all line bundles and hence no line bundle has all its
cohomology vanishing. On the other hand there are (plenty of) K3-surfaces with
an ample line bundle $\mathcal M$ and a line bundle $\mathcal L$ with $\mathcal
M\cdot\mathcal L=0$ and $\mathcal L^2=-4$. Then neither $\mathcal L$ nor its
inverse has global sections (as otherwise we would get a strictly effective
divisor with zero intersection with $\mathcal M$). Thus for line bundles at
least the problem restricted to K3-surfaces depends very much on the surface.
As for the idea of consider the cokernel $B$ of $\mathcal O_X\rightarrow
F_\ast\mathcal O_X$. We have that the cohomology of $B$ vanishes if $X$ is
ordinary. The general complete intersection is ordinary (by a theorem of
Deligne) so there are plenty of those. Raynaud has also shown that if $X$ is a
curve then $B\bigotimes \mathcal L$ has vanishing cohomology for the general
line bundle $\mathcal L$ of degree $0$.

A: The bundles with no derived global sections (more generally the objects $F$ of the derived category $D^b(coh X)$ such that $Ext^\bullet(O_X,F) = 0$) form the left orthogonal complement to the structure sheaf $O_X$. It is denoted $O_X^\perp$. This is quite an interesting subcategory of the derived category.
For example, if $O_X$ itself has no higher cohomology (i.e. it is exceptional) then there is a semiorthogonal decomposition $D^b(coh X) =< O_X^\perp, O_X >$. Then every object can be split into components with respect to this decomposition and so many questions about $D^b(coh X)$ can be reduced to $O_X^\perp$ which is smaller. Further, if you have an object $E$ in $O_X^\perp$ which has no higher self-exts (like $O(-1)$ on $P^2$), you can continue simplifying your category --- considering a semiorthogonal decomposition $O_X^\perp = < E^\perp, E >$. For example if $X = P^2$ and $E = O(-1)$ then $E^\perp$ is generated by $O(-2)$, so there is a semiorthogonal decomposition $D^b(coh P^2) = < O_X(-2), O_X(-1), O_X >$ also known as a full exceptional collection on $P^2$. It allows a reduction of many problems about $D^b(coh P^2)$ to linear algebra.
Another interesting question is when $O_X$ is spherical (i.e. its cohomology algebra is isomorphic to the cohomology of a topological sphere). This holds for example for K3 surfaces. Then there is a so called spherical twist functor for which $O_X^\perp$ is the fixed subcategory.
Thus, as you see, the importance of the category $O_X^\perp$ depends on the properties of the sheaf $O_X$.

A: This response doesn't quite answer your question, but it may provide some interesting further examples.
A supernatural sheaf on $\mathbb P^n$ (really some twist of such a sheaf) has this property, though supernaturality is much stronger than you are looking for.  A supernatural sheaf $\mathcal F$ is defined by two conditions:

*

*For every $j\in \mathbb Z$, there exists at most one such $i$ such that
$$
H^i(\mathbb P^n, \mathcal F(j))\ne 0.
$$

*The Hilbert polynomial $\chi(\mathbb P^n, \mathcal F)$ has distinct integral roots.
Hence, if $\mathcal F$ is supernatural and $e$ is a root of $\chi(\mathbb P^n,\mathcal F)$, then $\mathcal F(e)$ has the property that $H^i(\mathbb P^n, \mathcal F(e))=0$ for all $i$.
This is really the answer to a different question, but Eisenbud and Schreyer show that these sheaves can be used to generate the cohomology table of any sheaf.  In addition, you could probably apply their constructions to build further examples of sheaves with the property that you are looking for.  See
http://arxiv.org/abs/0712.1843 or http://arxiv.org/abs/0902.1594.
Hope this helps.

A: I haven't really thought about it, so I can't say whether there is good description
in general. But here a class of examples, which suggests to me that such the set of such sheaves of fixed rank won't always form a bounded  family. Take a smooth rational surface $X$, and choose a smooth rational curve $C\subset X$.
The ideal sheaf fits into an exact sequence
$$0\to \mathcal{O}_X(-C)\to \mathcal{O}_X\to \mathcal{O}_C\to 0$$
Writing out cohomology, one sees that $H^i(X,\mathcal{O}_X(-C))=0$ for all $i$.
Edit It's interesting to read other people's perspectives on this. But, anyway, for some
reason I didn't finish my thought yesterday.
To get an unbounded family, take $X$ to be a rational surface with infinitely many exceptional
curves $C$ (which exists thanks to Nagata).
Then the collection $\{\mathcal{O}_X(-C)\}$ gives an infinite
set of such sheaves with distinct Chern classes.

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Santa Barbara takes on a slew of the greatest living American playwrights this spring, with major productions of works by Sam Shepard, Edward Albee, Tony Kushner, Lee Blessing, and Richard Greenberg. There's also something by an Englishman named Shakespeare, and two important American premieres of contemporary plays from Finland.
Loose Affiliation of Artists had a hit last fall with Neil LaBute's The Shape of Things, and they look set to score again with this contemporary revenge play. Expect extreme conflict from this edgy new company. Thu., Mar. 29-Sat., Mar. 31, and Thu., Apr. 5-Sat., Apr. 7, 8pm. Center Stage Theater, 751 Paseo Nuevo. Call 963-0408 or visit centerstagetheater.org.
Two fully clothed actresses portray 14 female characters in this roaring comedy from Texan playwright Paula Coco, with live music by singer/songwriter Kacey Jones. Thu., Apr. 5-Sat., Apr. 7, 8pm. Lobero Theatre, 33 E. Canon Perdido St. Call 963-0761 or visit lobero.com.
Richard Greenberg's comedy about a Jazz Age publisher with a special printing press that can anticipate the future blends surreal science fiction with authentic New York characters, circa 1919. It's a great play that has a reputation for being difficult to pull off, which is just one of the reasons it's perfect for S.B.'s Ensemble Theatre Company. Fri., Apr. 6-Sun., Apr. 29. Ensemble Theatre Company, 914 Santa Barbara St. Call 962-8606 or visit ensembletheatre.com.
This classic Moss Hart and George S. Kaufman comedy gets its second production in the area in as many years when the PCPA gang gives us another chance to spend the holidays with that adorable curmudgeon Sheridan Whiteside. Thu., Apr. 12-Sun., May 13. Marian Theatre, Allan Hancock College, 800 S. College Dr., Santa Maria. Call 922-8313 or visit pcpa.org.
Genesis West presents this recent effort by Sam Shepard, a "comedy" about plutonium poisoning in America's heartland that the playwright describes as "a takeoff on Republican fascism." Shepard was motivated to write The God of Hell by the impending 2004 election season. As directed by our own Maurice Lord, the play's message may be even more urgent in 2007. Fri., Apr. 13-Sat., Apr. 28. Center Stage Theater, 751 Paseo Nuevo. Call 9630408 or visit centerstagetheater.org.
In sympathy with her husband, an American hostage held and tortured by Shi'ite Muslims in Beirut, a woman strips her den to resemble his cell and explores ways to share his suffering. This amazingly prescient play premiered in 1988, a year after Lee Blessing's similarly political A Walk in the Woods stormed Broadway. Presented by Santa Barbara Theatre; Asaad Kelada directs. Thu., Apr. 26-Sat., Apr. 28, 8pm; Sun., Apr. 29, 2pm. Lobero Theatre, 33 E. Canon Perdido St. Call 9630761 or visit lobero.com.
Edward Albee is enjoying a renewed interest in his work due to the notoriety of his recent The Goat, or, Who Is Sylvia? This drama from 1975 involves a different and less shocking, yet still unusual, encounter between species. It also echoes the two-couples format of Albee's Who's Afraid of Virginia Woolf? Oh, and it won the Pulitzer Prize-the second of Albee's three. Presented by SBCC Theatre Group. Fri., Apr. 27-Sat., May 12. SBCC's Jurkowitz Theatre. Call 965-5935 or visit sbcctg.sbcc.edu.
Shakespeare as interpreted by the inimitable Lit Moon. This production was one of the highlights of the Lit Moon World Shakespeare Festival, so catch it now if you didn't then. Fri., Apr. 27, 7pm. Porter Theatre, Westmont College, 955 La Paz Rd. Visit litmoon.com.
The Mel Brooks musical comes to the Arlington Theatre for three nights, so there's no excuse not to spend some quality springtime with Hitler and Germany. Mon., Apr. 30-Wed., May 2, 7:30pm. Arlington Theatre. Call 9634408.
By UCSB playwrights. Fri., May 18 and Sat., May 19, 8pm; Sun., May 20, 2 and 8pm; Tue., May 22- Fri., May 25, 8pm; Sat., May 26, 2 and 8pm. UCSB's Performing Arts Theatre. Call 893-3535 or visit www.artsandlectures.sa.ucsb.edu.
The most impressive, visionary American play of the 1990s gets a main-stage production from UCSB's drama department. Fri., May 25, 8pm; Wed., May 30-Sat., June 2, 8pm; Sun., June 3, 2pm. UCSB's Hatlen Theatre. Call 893-3535 or visit www.artsandlectures.sa.ucsb.edu.
Queen C by Laura Ruohonen and For the Sheer Love of Me by Anna Krogerus are contemporary Finnish plays that will be presented in a collaboration between Lit Moon and the Finnish Theatre Information Centre. Mikko Viherjuuri directs For the Sheer Love of Me, making him the first Finnish director to stage a play with a professional theater company in the United States. Fri., June 8-Sat., June 16, times TBA. Center Stage Theater, 751 Paseo Nuevo. Visit litmoon.com.


text:
WASHINGTON--More Power Outages Possible
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More Power Outages Possible
Story Filed: Monday, March 13, 2000 6:59 PM EST
WASHINGTON (AP) -- Rapid change in the electricity industry is causing reliability problems that could increase the likelihood of power outages this summer, Energy Secretary Bill Richardson said Monday.
He urged Congress to enact legislation that would require mandatory reliability standards for wholesale power producers to provide additional protection against power disruptions as the industry becomes more competitive.
Congress must pass legislation to restructure the electric utility industry as it becomes competitive or risk ``more long, hot summers of outages in America's cities,'' Richardson told a meeting of mayors and other local officials.
Lawmakers for several years have been considering legislation that would establish a national program of electricity industry deregulation, ending the historic monopolies utilities have had in their local service areas.
Many states already have moved toward some degree of competition, allowing consumers to choose their supplier of electricity, although the actual power still would come over the same local distribution system. National electricity deregulation bills have been stymied by disagreements among various segments of the $200 billion electric power industry, and opposition from some states where electricity already is cheap.
But an Energy Department report says the transition to competition has strained transmission and distribution lines, and caused some utilities to focus on competing for markets, cutting costs and maximizing prices, instead of assuring that power is kept flowing.
The final report was released Monday, although much of its key findings were made public in an interim document in January. Richardson said the review's findings ``conclude that without action (on the federal level) things could get worse before they get better.''
Last week, Richardson told a conference of state regulators that the system of voluntary reliability rules, established by the industry itself, is inadequate in the current competitive market system.
``We need mandatory reliability standards for (wholesale) power providers,'' Richardson reiterated Monday in his address to the National League of Cities. That would require action by Congress as part of an electricity industry restructuring bill.
Richardson also has raised concerns about large power providers manipulating prices.
Despite the movement toward competition, electricity supply in some parts of the country remains ``highly concentrated in the hands of only a few companies,'' Richardson said.
``This raises a warning flag that these companies will be able to dominate the market and raise prices,'' he recently told a conference of state utility regulators. He accused ``a handful of utilities and other organizations'' of using a ``state's rights'' argument to block federal rules needed to ensure reliability and market power abuses.
The DOE report released Monday said that while many states have made significant progress in developing competitive electricity markets, their efforts to develop market-based mechanisms to ensure against power disruptions have lagged behind.
The report was prepared by a task force, made up of power industry experts from the government and private industry. They were asked to examine power disruptions and electricity price spikes that occurred during high electricity demand last summer and how to prevent a repeat of the same problems this summer.
The incidents examined included outages last summer in Chicago, New York City, Long Island, New Jersey, parts of the mid-Atlantic states, Mississippi, Arkansas, Texas and Louisiana as well as some non-outage electricity grid disturbances in New England and the mid-Atlantic states.
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