text:
Horace Fenton Spurgeon meets Albert Argyle; Story meets Blake (Sexton); past meets present; reality meets surreality; and the collision spills out into a metafiction of absurd humour that is so far off the wall, the wall can no longer be seen. This is, in fact, classic Story, recapturing (in 1990) something of the lighter hearted mood of his novels of the '60s. Yet the darker period through which he had travelled never completely lost its hold on his work. There is a harder edge beneath the romp.
Story ties together the chaotic lives of his two major 'creations' through the medium of Claude Marchmont, a tally man stepping into the shoes of the deceased Albert Argyle and inheriting all of Albert's troubles. But the background story, offering a different perspective on A Company of Bandits (one of Story's Sexton Blake novels) and mixing in various other criminal concerns, is just a vehicle. The true heart of this novel are the characters who, as in many of Story's novels, are both caricatures and very real at one and the same time.
With a deft hand we are shown the chaos of human life and the way in which we muddle through against all the odds, how we are driven by some very basic concerns, how we find warmth in the dark from very simple pleasures.
Yet this work does something else. Quite apart from its wonderful character portraits and its cast of strange extras, it is a metafiction that wanders with ease between fiction and reality in a way that would make some 'serious' 'literary' novelists weep with envy. We move between layers of fiction (Albert Argyle had something of Story in him, but his books were as much a portrait of an age as anything else; Horace Spurgeon Fenton was a lightly fictionalised self portrait; we find mention of work that Story produced for television and film, as well as his novels), we move between past and present, we move inside and outside of the author's head.
At no time, however, does Story lose sight of the fact he is writing an entertainment. The structure (in form of the story about a train robbery) is there and well constructed; the characters are (in terms of the novel) believable; and the whole thing zips along at a wonderful pace. You barely have time to draw breath; events are often confusing because of the pace although the reader is never cheated. If you treat the novel with respect and allow Story's style to unfold, you are rewarded with an intelligent, exuberant, and first class piece of writing.
The Female Man is a truly astonishing novel. It first appeared in 1975 and I have since worn out two copies. This is my first reading of a new copy and it still surprises me, not to mention the awe and jealousy I also always feel. Awe that such a superb work can be written; jealousy that such a superb work can be written and I know I'll never come anywhere near.
Words like 'visionary', 'powerful', 'classic', 'significant' have all been applied to this work. And they are all true. If you have not heard of the book it is probably because it also has two other labels: 'feminist' and 'science fiction'. Yes it is both, because at heart it is about the experience of women and it uses the idea of alternate worlds to make its point. But it transcends those labels in a way that makes them almost irrelevant. Only almost, because Joanna Russ, thankfully, has never shied away from be a writer of sf.
In the novel four alternative versions of the same person are drawn from their four alternative worlds. And that's about it. There are subplots, but the vehicle itself is more than enough to carry the dark wit that is used to explore what it means to be a woman. The different worlds offer different perspectives, such that we can also conclude that rather than four worlds we are offered a glimpse into four archetypes, jostling for room in a single mind.
We see a world that never climbed out of the 1930s and never shed the psychic straightjacket that most women wore throughout their lives. In another we see a world where men have long since died off (and it is no utopia). A third world is torn apart by a literal war of the sexes. And sadly my dull description does none of it any justice. Because Russ is an impeccable stylist, some who has a real power over words, someone who makes them run as smooth and warm as honey, as dark and rich as chocolate, as sharp and powerful as a storm.
The intricate weaving of the four tales contrasts and compares the experience of the women in their different worlds. The sparse action allows both character and ideas to have a life of their own that is every bit as intriguing and suspenseful as any action thriller. The writing is assured, subtle; at times laugh out loud funny, at others the sharpness leaves you bleeding.
It is also a work of metafiction. The author is present (she is one of the characters), and we are treated within the text to some accurate observations on how the book (and feminism in general) is and will be greeted by all the usual suspects. Yet this is no vitriolic polemic; no rant. It is a clever and compassionate piece of writing; a superb piece of science fiction; a well argued work of feminist philosophy; and to my mind one of the truly great novels of the twentieth century.
The Thackery T. Lambshead Pocket Guide To Eccentric & Discredited Diseases - Vandermeer & Roberts [eds]
Not the sort of book you'd read at a single sitting, this is a truly eccentric work. The premiss is simple. Invite a number of distinguished writers to compose an entry to a medical dictionary of imaginary diseases. The result? Something that is playful, hilarious and deeply disturbing, sometimes at one and the same time.
It is also extremely insightful, not just of the contributing authors (for in their contributions we see snapshots of their preoccupations and their unique view of the world), but also of the modern world. Download Syndrome (a compulsion to record everything along with the use of appliances for thinking and communicating) sounds like a very real Syndrome to me. Printer's Evil sounds equally plausible – although I suppose it helps to have a slightly twisted mind.
If you like curios. If you like things that are just plain odd. Very odd. The very essence of odd. This is a book worth looking out for. However, it is not recommended for those who cannot read a medical dictionary without immediately being certain they have every symptom described therein. For such folk, reading this volume would be disastrous on a grand scale.
Guaranteed to reawaken those fantasies of being a mutant kangaroo.
During my teenage years I rode the train to and from school. Twice a day I passed the spot where Virginia Woolf drowned. Even given the changes since those dark days, the contrast always gave me pause for thought. I used to cycle and walk out that way as well, enjoying the peace, the wildlife, the beauty.
Naturally, I looked at Woolf's writing; which was enough for me. The woman was a genius with words. I have since revisited her books a number of times, each exploration revealing more about her and more about me. Yet I could never quite wrap my head around the way her life closed in on her so acutely she could think of only way out.
Having now read Hermione Lee's superb biography I now begin to understand. It is only a beginning, but that is usually the best place to start. I am not a big reader of biographies, especially of writers. As one myself, I know that the great bulk of their lives involves sitting at a table putting words on paper. Not very interesting in itself. And in many cases, their life is irrelevant to the finished product. But when the writer uses their own life and experience as the basis for their exploration of the human condition, then their life is often key to their interpretation.
The other reason I do not often read biographies is that they are usually dull reading. The author either sticks to recounting a series of events or tries to analyse them and ends up making a pigs ear of the silken purse they were first handed. Hermione Lee avoids all the pitfalls. Yes, she recounts the events of Woolf's life. Yes, she attempts an analysis. But she manages both with great style, with vitality, sympathy, and considerable insight.
At no time does she shy away from Virginia Woolf's difficult side (which Woolf herself was all too often painfully aware of), yet she treats this with an even-handed approach. Some of it can be explained, but people are often what they are and we have to take them as a whole. Just as we have to take the harrowing episodes in her early life along with the desperately dark inner turmoil that would squeeze the joy out of her life.
Unlike most biographies that leave me feeling like I know a character better, this one has left me feeling I know a real person a lot better. It is a model of biographical writing: scholarly and inclusive, warm and caring. I no longer travel past where Virginia Woolf died. I do not know if I will ever return to that part of the world. But I do know the unquiet ghost of my own lack of understanding will have begun to fade. I hope Virginia Woolf's spirit has found peace because she has made my world a better place.
This novel chronicles the ill-fated events that occur when a party of girls on a sponsored walk become separated from the world by a heavy fog. Set in Dorset, we follow the young girls as they wander ending, by a circuitous route, on the Isle of Portland. Cut off from 'civilising' norms, the girls quickly enter a dreamtime state in which they must provide all the explanations for events from their own limited pool of experience. The result is a potent mix of fairy tale, half understood (if keenly felt) observations of the adult world, and all the bits of knowledge that have yet to find a framework from which to hang.
All the normal tensions between the girls become exaggerated and all their obsessions become heightened. Alliances form and reform at great speed. The thin veneer of respectable behaviour is quickly stripped away. If this feels familiar, it is clear from the parallels in the book that Tennant is visiting old ground, but with a fresh eye. Applying a Carteresque sensibility to the question posed by Golding, we see young children becoming adults without the wherewithal to cope - physically or emotionally.
The episodes of what happened are interspersed in the novel with commentary by several adults. One is the author. Another is a doctor who has made a poor and outdated psychological assessment of one of the girls. These calm, reasoned voices contrast with the dreamy, chaotic, emotional journey of the children. They are dull and flawed; just as flawed (if not more so) than the elemental girls.
A sense of magic, of dream, and of raw emotional power, imbues this work. It throws out many more questions than it answers and remains the better for it. Any attempt to explain what happened (beyond that of the clearly flawed adult observers in the book) would have drained the work of any power. Readers of the book are treated as intelligent. The language, as ever with Tennant, is sharp and sparse, glimpses of events as the fog shifts, vignettes lit but sudden sunshine and just as quickly hidden.
I am not familiar with Tennant's later work (something I intend to rectify), but revisiting her earlier work is enlightening. Based on those early works alone, she is for me one of the great writers in English, head and shoulders above the all the usual (male) names that get trotted out and laved with adulation.
The Thackery T. Lambshead Pocket Guide To Eccentri...


It is well known that frequent feeding results in an increased feed intake and higher milk production. In addition, frequent feeding has a positive effect on the cow's health. However, labour is often a limiting factor in trying to provide cows with fresh feed 24 hours per day.
With the introduction of the Lely Juno feed pusher, Lely provides you with the ultimate solution. Based on the proven technique of the Lely Discovery mobile barn cleaner, the Lely Juno drives automatically over the feeding alley by following the feeding fence. It pushes the feed toward the fence as often as required without disturbing the cows. The Lely Juno is an easy to install, stand-alone machine which requires no additional facilities or modifications to your barn. This makes it suitable for almost all types of farms. The Lely Juno contributes to the welfare of your herd by stimulating the cows to approach the feeding fence more often. The cows have a better roughage intake and the herd is calmer and more tranquil. Low ranked animals will now also have sufficient access to fresh feed. The Lely Juno in combination with the Lely Astronaut robotic milking system shows a more consistent visiting behaviour to the robot day and night, resulting in even more efficient use of the Lely Astronaut. The Lely Juno feed pusher will save you a lot of valuable time and give you the flexibility and freedom to devote your energy to other tasks, knowing all the time that your cows are being taken care of in the best way possible.
The Lely Juno is a battery-operated vehicle, which returns to the charging station after each run. The charging station is mounted at a convenient point in the feeding alley. This charging station also functions as the starting point of each run. The route to be followed by the Lely Juno can be set by using the E-link control. This only has to be done once, when the pusher is installed. Programming couldn't be easier. The flexibility of the different routing possibilities ensures feeding can be evenly spread around the clock and that feed is available for the cows at all times, day and night.
The Lely Juno is driven by two wheels and supported by a third wheel. The built-in ultrasound sensor ensures that the feed pusher follows the feeding fence at pre-determined distances. The farmer programs these distances using the E-link, starting at a wide distance to the fence and gradually approaching.
A rotatable surface, at the lower part of the Lely Juno, pushes the feed towards the feeding fence while the vehicle moves in a straight line along the feeding alley. The main frame of the unit is formed by a heavy concrete block that gives the feed pusher the required mass to push the forage over the set distance. The Lely Juno features an inductive device sensor, which ensures the unit follows the pre-programmed routes accurately. This sensor detects the pre-installed metal strip near the charging station which marks the end of the route. The Lely Juno is suitable for all level and paved feeding alleys, can follow different types of feeding fences and is able to push feed piles as high as 75 cm.
As the Lely Juno runs in the feeding alley, which is an easily accessible part of the barn, safety is of the utmost importance. A special feature has been designed on the feed pusher; the collision detector. This ensures the feed pusher stops immediately if it encounters an obstacle.
24 hour operation - The constant availability of feed stimulates extra cow traffic, especially during the night when feed is not normally pushed to the fence.
Increased Forage Intake - The Lely Juno stimulates the cows to approach the feeding fence most often resulting in a higher dry matter intake and less waste feed.
Equal Quality Ratio Available Day or Night - With the Lely Juno, all feed is constantly pushed towards the feeding fence. This gives an equal mixture during the day and night.
Cost Saving - Better intake means less waste forage. Saves labour as well as machines and fuel. The Lely Juno is equipped with an energy friendly electric motor.
More Peace in the Herd - Due to the regular action of the Lely Juno, low ranking cows can also access fresh feed after the high ranking cows have eaten their ration.
Labour Saving - Assuming a round takes only 10 minutes, the Lely Juno will save you at least 183 hours or in other words 22 (8-hour) working days annually!
What kind of setup do I need in my barn?


text:
Ab Tumhare Hawale Watan Saathiyo () is a 2004 Indian war film, directed by Anil Sharma and starring Akshay Kumar, Amitabh Bachchan, Bobby Deol, Divya Khosla Kumar, Sandali Sinha and Nagma.

Plot
Major General Amarjeet Singh (Amitabh Bachchan) is a dedicated officer for the Indian Army. His son Captain Vikramjeet Singh (Bobby Deol) follows in his footsteps and joins the Navy. In 1971 during the Indo-Pak war and the formation of Bangladesh, Lt. Commander Vikramjeet Singh has a ship in his command and a regiment of soldiers of the Indian Army, commandeered by his dad, Major General Amarjeet Singh. The ship comes under attack by a submarine of the Pakistani Navy, undergoes damage, and sinks along with Vikramjeet, but not before he courageously rescues about a hundred trapped army personnel.

Years later, Vikramjeet's son Kunaljeet joins the army as a captain, but he lacks the values his dad and grandfather had in them about serving the country selflessly. He just wants to be employed with the army for a couple of years, then re-locate to the U.S., run a business, and become rich. In order to accomplish this he always makes up excuses of not going to the front. He falls in love with Shweta Bhansali (Divya Khosla Kumar), and decides to stay in the army in order to be close to her. In order to achieve a medal, he fakes heroism; then carelessly jeopardizes a planned attack on terrorists and as a result many terrorists escape to their hideouts. Disciplined and chastised, an injured and humbled Kunaljeet waits to meet his sweetheart - only to find out that she is in love and married to his senior officer Major Rajeev Kumar Singh (Akshay Kumar), who was assumed to be dead but actually was a prisoner of war. The only thread binding him to the army is broken, and it is then Kunaljeet finds out that the terrorists in collusion with rebel Pakistani officers are planning to bomb the Bhagwan Shivji's Amarnath Temple in Jammu & Kashmir in order to forment communal strife. Kunaljeet saves everyone and wins his grandfather's heart.

Cast
 Amitabh Bachchan as Major General Amarjeet Singh (Defence Adviser of India after retirement), Vikramjeet's father and Kunal's grandfather
 Akshay Kumar as Major Rajeev Singh After Promotion Colonel Rajeev Singh, Kunal's senior officer and Shweta's husband
 Bobby Deol as Lt Cdr. Vikramjeet Singh/ Capt. Kunaljeet 'Kunal' Singh After Promotion Major Kunaljeet Singh
 Divya Khosla Kumar as Shweta Bhansali / Shweta Rajeev Singh, Rajeev's wife and Kunal's love interest
 Sandali Sinha as Captain Dr Sakshi Pant
 Nagma as Aarti Vikramjeet Singh, Vikramjeet's wife and Kunal's mother
 Utkarsh Sharma as Kunal / Vikramjeet Singh (Childhood)
 Kapil Sharma as Captain Trilok (deceased in war)
 Danny Denzongpa as Col. Ashfaque Khan
 Ashutosh Rana as Sikander Khan
 Govind Namdeo as Maqbool Butt
 Vivek Shauq
 Surendra Pal
 Aarti Chabria as Trilok's wife
 Arif Zakaria
 Rajesh Vivek
 Vishwajeet Pradhan as Subedar Abdul
 B N Sharma as Police Man

Soundtrack
The music is composed by Anu Malik. Lyrics are penned by Sameer. The Song "Humein Tumse Hua Hai Pyaar" become extremely popular.

Track listing

References

External links

2004 films
2000s Hindi-language films
Indian war films
Pakistan Navy in fiction
India–Pakistan relations in popular culture
Films scored by Anu Malik
Indian Army in films
Military of Pakistan in films
Films directed by Anil Sharma
2000s war films

redpajama_set_name: RedPajamaWikipedia


BACKGROUND: Studies in other fields have documented a relationship between temperature and surgical site infection. We reviewed our multi-institution database of inflatable penile prosthesis infections to examine the relationship between inflatable penile prosthesis (IPP) infection,culture positivity, time of year, climate, temperature, humidity, and organisms responsible for infection.
METHODS: This is a retrospective IRB-approved analysis of 213 patients at 25 institutions who underwent salvage procedure or device explant between 2001 and 2016. Patient data were compiled after extensive review of operative reports, nursing operative data, intraoperative wound cultures, perioperative antibiotics, inpatient notes, consult notes, and follow-up visits. Climate data were compiled from monthly norms based on location, as well as specific data regarding temperature, dew point, and humidity from dates of surgery. Rigorous statistical analysis was performed.
RESULTS: Infected implants performed in the summer or fall were 2.7 times more likely to grow Gram-positive bacteria compared to implants performed in spring (p=0.005). 139 infections occurred at average daily temperatures greater than 55 degrees F, compared to 72 infections at less than 55 degrees F. The incidence rate ratio for this trend was 1.93, with a p-value of <0.001. 40% more implants would have to be performed at temperatures less than or equal to 55 degrees F than were performed at greater than 55 degrees F for this difference not to be significant. Infections were more likely to occur in devices placed in spring months (61), although the small sample size and lack of a denominator precluded statistical significance. This was consistent across geographic location, including in the Southern hemisphere. Assuming that a similar number of implants are performed in every quarter, the incidence rate ratio for this trend is 1.49, with a p-value of 0.05. Infections occurred most frequently in IPPs placed in June (24). Fewer infections occurred in IPPs placed in winter months (39), with the lowest number occurring in March (11). There were 58 infections in summer months and 55 in fall months.
CONCLUSIONS: To our knowledge these data represent the first exploration of the relationship between temperature and infection in prosthetic urology. Gram-positive infections are nearly 3 times as likely in the summer or fall. Temperature correlates with rates of IPP infection. Infections occur less often in winter months and more often in spring months in our series. Further investigation is needed to confirm our results.


Our strong Pro leather belts are super strong, durable & offer great value for money. 10cm wide (4 inches) and 10mm thick. These belts feature a high quality buckle with two pins for good stability and optimum length for ease of release. Sculpted front for secure and easy tightening. 4 lines of enforced white detail stitching around the outside of the belt with 6 power rivets securing the buckle.
Choose your waist size from the options below. Belt sizes are measured in inches from the tightest loop holes up to the loosest.
Each belt has 8 sets of holes giving you maximum margins to get the right tension for you.
The only reason i bought this belt was it comes in an 'extra small'. I am tiny and finding a belt of this standard to fit has been a real struggle. Its excellent, in fact it's made such a difference to my training i can't believe i went so long without it! Enough holes to adjust if need be and very thick so the support is fantastic. A maximum 5 stars from me.
Got my belt last week and its top quality. Cheaper than other 'branded' belts but exactly the same.


After a huge success of On's very first Live Music Workout, the event has travelled around the globe and is now finally coming back to it's birth place.
Be the first to experience the new limited-edition Cloud X Ultraviolet at Balboa Bar & Gym. This high-vis mixed workout shoe is beyond light and made to move. Rock out as you work out with live music from Swiss sensations JAS CRW – it's glow time.
This will be a workout not only your muscles will remember.
Click on the class you want to go to in the schedule above. This will redirect you to the MindBody sign-up. If you're already a member at Balboa - you know the process. If this is your first time training at Balboa, you will have to sign up the same way, but will not be charged.
Limited spots, so sign up fast!
Our partner We Run has reserved a number of this limited Cloud X editions that will be available to purchase during the event. Don't miss the chance to get your hands on a pair!
*You participate on your own risk. During the event we will take photos and videos. With signing up you confirm that we are allowed to film you.
Balboa Bar & Gym - the Gym of the future is a cross-disciplinary lab for finding your roots and own elements. Stronger does not mean inflexible. Balboa's body shape is a creative workout without conventions. Raw strength for a strong nature is the path of your empowerment. Body and heart go together, living and training too. Balboa re-invents the concept of fitness to create a new kind of urban exchange. Going in one more round when you do not think you can – as Rocky says – that's what makes all the difference in your life.


Dance Around the World • Dance or Die !
Dance to expand your awareness, radiance, aliveness and passion! Dance because you can! Dance even if you think you can't!
DOWNLOAD WEST AFRICAN DANCE LESSONS !
Listen to sample music tracks.
Copyright Dance or Die © All rights reserved. Designated trademarks are the property of designated owners.


The Kyriad Prestige City Center – Palais des Arts 4 Star offers you all the comfort you need : air conditioning, Kiosk, night watchman, safe box at the reception, Wi - Fi high flow and access to wired channels in rooms. A bottle of water and a tea will be offered on your check-in.
The 58 rooms, spread over four levels, have been entirely decorated in a minimalist style, and contemporary design.
Our hotel offers modular lounges, You can rent for seminars and business meetings successful, but also your business cocktails.
Our lounges have a "K Business" label as a guarantee of comfort, services, for a service adapted to your needs. This label guarantees, listening, transparency for the rates, customization and high technology equipment. Everything is implemented so that you can work in good conditions.
On the ground floor, We offer a Bar Lounge , composed of 2 lounges, Open from 6 h to 1 h to relax after a long day of work or sightseeing.
A good way also to find yourself in a friendly atmosphere, with friends, familly or collegues.


Writer's Block - Hand Poured - 10oz Soy Candle – MLC Co.
Welcome to our newest collection, our Modern Anthology line. The candles will come a modern style jar with both a wood wick and lid. The lid will be branded with our company logo, to give it that extra little touch!
Writer's Block is the perfect fall candle for anytime of the year! It's sweet, warm and spicy! This is the most comforting scent for someone who has hit a wall in their writing and just needs a little scent therapy!
If you like this scent, check out our same scented Bath and Body line!
Pumpkin Apple Butter: Rich buttery tones envelop the scent of sweet apple as this fragrances reveals mid-notes of spiced cinnamon and pumpkin. Warm woodsy base notes with a hint of vanilla sugar create the perfect finish to this warm and spicy fragrance.
In the hotter months please make sure someone is home to bring your order inside. Candles sitting outside in this hot climate will melt. Once an order is with USPS it is out of our control if candles melt.
Candles are made to order, please see the banner on the page above to see our current processing times. Candles will be shipped once the candle has fully set. Shipping time is 3-5 days within the United States.


text:
Q: How to upload file with graphql and graphene I'm trying to upload a file using graphql and graphene.
On frontend I have fetch request as follows:
fetch(
            '/graphql', {
                method: 'POST',
                headers: {'Content-Type': 'application/json'},
                body: JSON.stringify({query: MUTATION, variables: {file: file}})
            })
            .then(res => res.json())
            .then(res => {
                debugger;
            })
            .catch(error => {
                debugger;
            });

And mutation is as follows:
const MUTATION = `mutation UploadMutation($file: Upload!) {
        uploadMutation(file: $file) {
            ok
            url
        }
    }`;

And on the backend side I have mutation as follows:
class UploadMutation(graphene.Mutation):
    class Arguments:
        file = Upload(required=True)

    ok = graphene.Boolean()
    url = graphene.String()

    def mutate(root, info, file, **kwargs):
        url = handle_upload_file(file)
        ok = True

        return UploadMutation(ok=ok, url=url)

The uploaded file is as follows:
lastModified: 1569487573753
lastModifiedDate: Thu Sep 26 2019 10:46:13 GMT+0200 (Central European Summer Time) {}
name: "1.png"
path: "1.png"
size: 138373
type: "image/png"
webkitRelativePath: ""

But in the mutate function I get:
{'path': '1.png'}

Any idea what am I doing wrong?

redpajama_set_name: RedPajamaStackExchange


text:
white-hat
Smart Bomb Epilogue
In a valley of the Two women each wearing a full face Burqa walked towards the Mosque where several black-clad and masked men stopped them.
They whispered just loud enough to tell the enforcers of morality where they were traveling and who they were to meet.
Taken to the mosque, the guards searched the women for weapons or explosives, then led below to the first sub-basement two stories under the ground to an opulent room with a raised dias.
The fifty-one year old Supreme Leader and Prophet stepped out from behind a bomb resistant door after the guards explained that the women were local converts who wished to missions for him.
"Women, what honor do you wish to perform?"
"Oh wise one, first, before I give you my heart, I humbly request one thing." Her eyes glittered with sensuality behind the heavy drape of cloth. She held out a graceful, delicate hand with just the index extended. "Pull my finger."
"Dateline Russia, WorldNetNews
Today the United Nations announced that sensors had detected an extremely large explosion in a remote area of the Russian Federation. Russian authorities deny weapons of mass destruction have been tested. There are no other reports coming from the area that the Russian authorities have closed off to all traffic. Downwind in the polar jet stream a large amount of dust has been observed in the upper atmosphere, but authorities say they have not detected any significant radiation. Theories are that the explosion could the result of an unknown comet or meteor, unknown number of casualties in the sparsely populated area. More on the explosion as news develops elsewhere in the news, typhoon Felix has taken a northerly track out to the open ocean…"
Turning off the video display, Thor, Lady Sif, Burning Chip, Running Man, Alvin and Walter "Big Boom" began to toast each other.
"Antimatter threat has been neutralized, Walter." Alvin said quietly.
"No, it hasn't. Just this one threat. Each time we will do this, there will be more, but we have discovered ways to win that problem." Walter said as he typed more nicknames on the screen.
"Whoa! What do you mean "Each time"? Sif's eyes were wide. "We do not have that kind of network."
"We have something better." The round faced computer whiz smiled. Turning the monitor so the rest of the team could see, an image shot from a helicopter of columns of smoke drifting out of a two-mile-wide crater with a subtitle "You are always my brothers and sisters. I have learned this new term I will use. Love Steve." The image less than six hours old, intercepted from the most secure network the Russian Military had.
"Steve is still with us." Walter smiled and took a bite of a chocolate bar, washing it down with his soda.
"Antimatter explosions do not leave radioactive fallout." Running Man fistbumped Burning Chip. "No new android bombs."
"We hope." Thor wished. "If there is another, how do we catch a shape shifting android?"
"Walter." Alvin said. "Reply to Steve with our worry. Like it or not, we are a white-hat team."
"No! I don't want to be a white-hat, thems are real nerds." Walter grumped as he tapped the keys to answer Steve.
Walter, the unwilling White-Hat made the rest of them laugh with the irony.
A black-hat saved the world.
Tags android, antihero, black-hat, bomb, chocolate, explore, explosion, hacker, nerd, saved, soda, team, terrorism, white-hat

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Android Broadcast not execute when clear from ram Hi i created broadcast receiver which receive Battery level on Intent.ACTION_BATTERY_CHANGED event. It works good but when i remove this app from ram using swipe from holding home button then it doesnt receive event.
My code of Broadcast is
private BroadcastReceiver BatteryReceiver = new BroadcastReceiver() {

    @Override
    public void onReceive(Context context, Intent intent) {
        // TODO Auto-generated method stub
        int level = intent.getIntExtra("level", 0);
        Toast.makeText(BatteryIndicatorService.this,""+level, Toast.LENGTH_SHORT).show();
    }
};

A: This can be done when your broadcast run in background for that you need to create service.In this service you have to define your Broadcast.

BatteryIndicatorService.java

public class BatteryIndicatorService extends Service {
private BroadcastReceiver BatteryReceiver = new BroadcastReceiver() {

    @Override
    public void onReceive(Context context, Intent intent) {
        // TODO Auto-generated method stub
        int level = intent.getIntExtra("level", 0);
        Toast.makeText(BatteryIndicatorService.this,""+level, Toast.LENGTH_SHORT).show();
    }
};

@Override
public IBinder onBind(Intent intent) {
    // TODO Auto-generated method stub
    return null;
}

public void onCreate() {
    // TODO Auto-generated method stub
    super.onCreate();
    // Register Receiver.
    registerReceiver(BatteryReceiver, new IntentFilter(
            Intent.ACTION_BATTERY_CHANGED));
}

public void onStart(Intent intent, int startId) {
    // TODO Auto-generated method stub
    super.onStart(intent, startId);
}

@Override
public void onDestroy() {
      // TODO Auto-generated method stub
      super.onDestroy();
   }
}

And Start it from MainActivity like

MainActivity.java

protected void onCreate(Bundle savedInstanceState) {
    // TODO Auto-generated method stub
    super.onCreate(savedInstanceState);
    setContentView(R.layout.main);
    // Start service in Background
    startService(new Intent(this, BatteryIndicatorService.class));
 }

Define Service in Manifest.xml in application tag

manifest.xml

<service
        android:name="com.ittl.batteryindicator.BatteryIndicatorService"
        android:enabled="true" >
</service>


It's more than halfway through summer, time to brush up on your barbecue game.
To the self-proclaimed backyard grill master: We know, we know—you know what you're doing. But, you might want to keep reading to touch up on your game or learn some healthy grilling techniques. On the other hand, if you've been too scared to touch the grill all summer, letting others man the meat, this advice is just what you need for some added confidence. Here are some tips and techniques from a true master, Joe Sasso, Executive Chef of The Great American BBQ Co., the pop-up barbecue joint that operates at Sam's of Gedney Way in White Plains every summer.
If you are using a gas grill, do not turn all the burners on high. From left to right, you should keep the left burner on low or off, the middle burner on medium, and the right burner on high. You start grilling on the right side and move the food over to medium, and then to low or no heat.
Remember to season your grill with oil before placing food on the grill in order to reduce sticking. A lot of people season meats liberally before cooking them to get that delicious caramelized flavor, but are too eager to dig in to take the time to season on the way off the grill. Take a minute to sprinkle some sea salt, fresh cracked black pepper, and herbs to give it an extra fresh kick right before serving.
The most important tip we got from Sasso is to let meat rest for five minutes before eating or slicing.
He explains his method: "You load up the space on the bottom of the grill with a piece of newspaper or two, pile coals in from the top, then light the newspaper. The fire and heat from the newspaper ignites the bottom coals, and then the fire builds up. When the top coals are covered with gray ash, you're ready to go.
1. Remember that one serving of meat is only about three to four ounces and be sure to pair it with grilled vegetables. The healthiest options for meat are grass-fed beef, heritage breed pork, organic poultry, and wild seafood (rather than farmed).
2. Some veggie ideas: grilled artichoke halves served with roasted garlic and lemon aioli; grilled corn bites tossed with cilantro, lime, red chili flakes, olive oil, and queso fresco cheese; grilled whole leeks and sweet potatoes with salsa verde; grilled asparagus with chimichurri sauce; grilled Portobello mushrooms with barbecued onions; grilled jalapeños, scallions, and tomatoes for a flavorful salsa.
3. Dense root vegetables like potatoes, carrots, yams, beets, and rutabagas should be thinly sliced, tossed in oil and fresh herbs, and grilled with the cover closed. Serve them with your favorite dipping sauce, which you can make by puréeing any favorite delicate veggies like asparagus, scallions, red peppers, and tomatoes.


text:
Q: Variable "" has coerced Null value for NonNull type 'String!" GraphQl error I am trying to save groupChatName as the value of the TextInput and save that name on the backend but in doing so I am getting the error "Possible unhandled promise, data: null, variable 'groupChatName' has coerced Null value for NonNull type 'String'", path: null.
export const createGroupChat = `mutation createGroupChat($groupChatName:String! $messages:String $createdUser:String! $users:String) {
  createGroupChat(input:{
    groupChatName:$groupChatName
    messages:$messages
    createdUser:$createdUser
    users:$users
  }){
    groupChatName
    messages
    createdUser
    users
  }
}`;
  const [currentUser, setCurrentUser] = useState('');
  const [value, setValue] = useState('');
  const [groupChatName, setGroupChatName] = useState('');

  useEffect(() => {
    Auth.currentAuthenticatedUser()
    .then(currentUser => setCurrentUser(currentUser))
    .catch (() => setUsername(null));
    }, []);

  GroupChat = () => {
    if (value.length > 0) {
      setValue('')
      setGroupChatName('')
      props.navigation.navigate('Message', { value });
    }
  };

  GroupChatMutation = async () => {
    const GroupChatDetails = { groupChatName, currentUser };
    const newGroupChat = await API.graphql(graphqlOperation(createGroupChat, { GroupChatDetails }));
    console.log(JSON.stringify(newGroupChat));

  };

  return (
    <View style={styles.container}>
            <Text style={styles.header}>Create GroupChat Name</Text>
            <View style={styles.textInputContainer}>
                    <TextInput
                            style={styles.textInput}
                            multiline={true}
                            placeholder={'Type in a GroupChatName'}
                            placeholderTextColor="#abbabb"
                            value={value}
                            onChangeText={value => setValue(value)}
                            onChange={value => setGroupChatName(value)}

                    />
.......```


text:
Live Gig
Rock Vault
Shinedown, Godsmack, and Asking Alexandria at Von Braun Center Arena in Huntsville, AL on Sep 24th, 2018
Comments Off on Shinedown, Godsmack, and Asking Alexandria at Von Braun Center Arena in Huntsville, AL on Sep 24th, 2018
All Photos: Julius Richardson
Words: Shadow Editor
In what it could possibly turn out to be one the best Rock Tours to hit Huntsville all year (being cynical here as we don't get many, but we are getting better at that), Godsmack and Shinedown rumbled into town this past Monday at the Von Braun Center Arena and delivered a great night of music and intense pyrotechnics on stage. To no ones surprise, Shinedown sold very well as they have for a number of years, riding the past and successes of great records such as "Threat to Survival", "Amaryllis" and "The Sound Of Madness". They are not only a great US rock band, but their impact spreads overseas and beyond. So, I was really looking forward to checking them out in support of their new record "Attention Attention". (If you missed our review on that one, bang it here for more.) Godsmack on the other hand, is a group that I have not kept close tabs on since their global success of earlier albums the likes of "Awake" , "Faceless" and their self title chart breaking smasher. But in similar fashion they have a new record out "When Legends Rise" and their single "Bulletproof" has been very well received across the country. Good for them as I was curious to see how they play live, having never seen them in their heyday.
Before we get star struck by those bands, let's talk about Asking Alexandria, the opening band. Being somewhat lightly familiar with some of their older stuff, some fans opinion on their latest album is that they have changed up their sound a bit to something more mainstream. I have to agree, but that's not necessarily a bad thing, folks. Regardless, as the opener, you don't have much time to shine in a 30 minute set, but the guys quickly set the crowd on fire, literally with some pyro explosions, and set the tone for the other bands. I will say that when "Into The Fire" from their self title record last year started playing, it was pretty damn convincing with their driven energy. Vocalist Danny Worsnop is back and it shows. The man has a solid voice (forget the screamo parts), strong, raspy, clean voice that just fits the band great. Next, Someone, Somewhere (acoustic), was a nice homage to the military serviceman all over the world; it's a cool tune that hits on a personal level for many. They threw in a few other numbers from their last album in "Eve", which aligns more with their past work. All in all, not a bad opening to the night for a lot of long time fans. They are glad Danny is back and hopefully he sticks around as the guys have a strong fan base. If you blink you would have missed the set from these guys.
Asking Alexandria at Von Braun Center Arena in Huntsville, AL on Sep 24, 2018
The Shinedown curtains went up as it was almost time for one of the headliners to hit the stage. Shinedown quickly sent of volt of energy in this casual Monday night crowd at the VBC. I say casual, but the turn out was great and they were damn committed to the bands, especially when Shinedown took the stage. An oldie but a good one in "The Sound of Madness" helps kicks things in good Hard Rocking fashion. Any song the guys play from "Threat to Survival" is a guarantee to be pretty well received and this evening they played "Cut the Cord" first, which is perfect Modern Hard Rock with a tight tempo and keen lyrics. For those not following what we do here, we listen to a lot of music, I mean a lot of music throughout the year. "Threat to Survival" ended up on multiple top albums list from our staff writers, and we have a big time diverse group of music aficionados that listen to all kinds of genres. It was that good. I really enjoyed the message of "Get Up", the bands new single off "Attention Attention". Singer Brent Smith has said the message was inspired by the struggles of depression through the eyes of his band mate and bass player Eric Bass. Good song that got the crowd even more energized. Another sample of this modern influenced vibe tapping into more commercial success comes via "State Of My Head". You know you are doing something right on a Monday night, with weary after-work citizens of all ages banging their heads. Rock is a beautiful thing it brings people together. What more could you ask for? Brent started running towards the back platform on the lower level, damn near tripped over it as he climbs it, and shortly thereafter, a cover of Lynyrd Skynyrd's "Simple Man" started resonating to this southern crowed. Yep, they all approve. Nice touch guys, very well played. Brent provided some nice vocals on this one. The guys saved all the pyro for "Devil" which ended their set with fans reflecting on this massive performance. I overheard someone in the crowd saying in passing, "Shinedown is a heavier version of Imagine Dragons" … no. They are fucking Rock. Enough said, don't put those in the same sentence.
Shinedown at Von Braun Center Arena in Huntsville, AL on Sep 24, 2018
Bar was set high for Godsmack as they hit the stage with some clear lighting and nice display imagery behind the set. Frontman Sully Erna looks like he has never aged, and charismatic as ever, launched right into concert staples and favorites of many, "Awake" and "Keep Away". Those songs will always have a certain appeal to older fans, like myself. I admit, I listened heavily to their music around that time frame, because it was catchy metal then and it still holds audiences attention today. Another fan favorite came at you via "Voodoo". I've always loved that dark, subliminal and mystique sound. It was a cool tune then and still stands out today. I will admit that I would've preferred Sully cut some of the small talk and just keep playing at times, but his comment when an small audience member was asleep in the front of the audience was hilarious, as he suggested their music puts people to sleep. Come on, that's funny. Their single "Bulletproof" gets a number of course. It's nice tune and I can see it on holding in top charts across the country. It's catchy and still had that old school Godsmack rhythm and bass. My favorite from the night had to be the mobile drum kits from both drummer Shannon Larkin and Sully's own drum kit. They had a drum battle and it was damn impressive. Yeah, most know Sully is an accomplished drummer, but that's a cool twist to add to a performance.
Godsmack at Von Braun Center Arena in Huntsville, AL on Sep 24, 2018
The night ended quickly soon after and fans started plowing out of the arena as they rushed home to Tuesday's work day. Even though I gave the city a hard time for Black Stone Cherry (admittedly, it was smaller venue), the fans came out in force this evening, which made me proud of Huntsville. Keep it going, let's get more Rock bands here. We have a diverse city in great location that could be a stop of many tours as they fast track across the south. It's a booming city that deserves more great Rock music. In the end all bands had a nice showing, and to top it off, local Rock station, The Rocket 95.1, was celebrating their 18th birthday. What a way to do that than at this gig. Keep supporting the bands folks, and Rock!!!
For more information on Shinedown, please visit:
Facebook | Instagram| Twitter | Website | Atlantic Records
Tell Us How You Feel
Tagged 2018, AL on Sep 24th, Alabama, and Asking Alexandria at Von Braun Center Arena in Huntsville, Asking Alexandria, Godsmack, Hard Rock, Huntsville, Metal, shinedown, VBC
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2019 Myglobalmind Online Magazine | Editorial by MysteryThemes.


text:
// This file implements the IDataObject Interface and Gateway for Python.
// Generated by makegw.py
// @doc - This file contains autoduck documentation

#include "stdafx.h"
#include "PythonCOM.h"
#include "PythonCOMServer.h"
#include "PyIDataObject.h"
#include "PyComTypeObjects.h"

// @object PyFORMATETC|Tuple representing a FORMATETC struct describing an OLE data format
// @tupleitem 0|int|Format|CLIPFORMAT value (CF_*) identifying the type of data
// @tupleitem 1|None|td|DVTARGETDEVICE (currently not supported, use only None)
// @tupleitem 2|int|Aspect|One of pythoncom.DVASPECT_* values specifying level of detail
// @tupleitem 3|int|index|Usually -1, used only when data spans multiple pages
// @tupleitem 4|int|tymed|One of pythoncom.TYMED_* values indicating how the data is stored
BOOL PyObject_AsFORMATETC(PyObject *ob, FORMATETC *petc)
{
	PyObject *obtd;
	if (!PyArg_ParseTuple(ob, "HOiii:FORMATETC",
			&petc->cfFormat,
			&obtd,
			&petc->dwAspect,
			&petc->lindex,
			&petc->tymed))
			return FALSE;
	if (obtd!=Py_None) {
		PyErr_SetString(PyExc_ValueError, "td must be None");
		return FALSE;
	}
	petc->ptd = NULL;
	return TRUE;
}

PyObject *PyObject_FromFORMATETC(FORMATETC *petc)
{
	return Py_BuildValue("Hziii",
			petc->cfFormat,
			NULL,
			petc->dwAspect,
			petc->lindex,
			petc->tymed);
}

BOOL PyObject_AsPySTGMEDIUM(PyObject *obmedium, PySTGMEDIUM **pp)
{
	if (!PySTGMEDIUM_Check(obmedium)) {
		PyErr_Format(PyExc_TypeError, "Object must be a PySTGMEDIUM (not a '%s')", obmedium->ob_type->tp_name);
		return FALSE;
	}
	*pp = (PySTGMEDIUM *)obmedium;
	return TRUE;
}

// ---------------------------------------------------
//
// Interface Implementation

PyIDataObject::PyIDataObject(IUnknown *pdisp):
	PyIUnknown(pdisp)
{
	ob_type = &type;
}

PyIDataObject::~PyIDataObject()
{
}

/* static */ IDataObject *PyIDataObject::GetI(PyObject *self)
{
	return (IDataObject *)PyIUnknown::GetI(self);
}

// @pymethod <o PySTGMEDIUM>|PyIDataObject|GetData|Retrieves data from the object in specified format
PyObject *PyIDataObject::GetData(PyObject *self, PyObject *args)
{
	IDataObject *pIDO = GetI(self);
	if ( pIDO == NULL )
		return NULL;
	FORMATETC formatetcIn;
	PyObject *obpformatetcIn;
	// @pyparm <o PyFORMATETC>|pformatetcIn||Tuple representing a FORMATETC struct describing how the data should be returned
	if ( !PyArg_ParseTuple(args, "O:GetData", &obpformatetcIn) )
		return NULL;

	PySTGMEDIUM *pymedium = PyObject_FromSTGMEDIUM();
	BOOL bPythonIsHappy = TRUE;
	if (bPythonIsHappy && !PyObject_AsFORMATETC( obpformatetcIn, &formatetcIn )) bPythonIsHappy = FALSE;
	if (!bPythonIsHappy) return NULL;
	HRESULT hr;
	PY_INTERFACE_PRECALL;
	hr = pIDO->GetData( &formatetcIn, &pymedium->medium);
	PY_INTERFACE_POSTCALL;
	if ( FAILED(hr) ) {
		Py_DECREF(pymedium);
		return PyCom_BuildPyException(hr, pIDO, IID_IDataObject );
	}
	return pymedium;
}

// @pymethod <o PySTGMEDIUM>|PyIDataObject|GetDataHere|Retunrs a copy of the object's data in specified format
PyObject *PyIDataObject::GetDataHere(PyObject *self, PyObject *args)
{
	IDataObject *pIDO = GetI(self);
	if ( pIDO == NULL )
		return NULL;
	FORMATETC formatetc;
	PyObject *obpformatetc;
	// @pyparm <o PyFORMATETC>|pformatetcIn||Tuple representing a FORMATETC struct describing how the data should be returned
	if ( !PyArg_ParseTuple(args, "O:GetDataHere", &obpformatetc) )
		return NULL;
	BOOL bPythonIsHappy = TRUE;
	if (bPythonIsHappy && !PyObject_AsFORMATETC( obpformatetc, &formatetc )) bPythonIsHappy = FALSE;
	if (!bPythonIsHappy) return NULL;
	PySTGMEDIUM *pymedium = PyObject_FromSTGMEDIUM();
	HRESULT hr;
	PY_INTERFACE_PRECALL;
	hr = pIDO->GetDataHere( &formatetc, &pymedium->medium);
	PY_INTERFACE_POSTCALL;
	if ( FAILED(hr) ) {
		Py_DECREF(pymedium);
		return PyCom_BuildPyException(hr, pIDO, IID_IDataObject );
	}
	return pymedium;
}

// @pymethod |PyIDataObject|QueryGetData|Checks if the objects supports returning data in a particular format.
// @rdesc Returns None if the object supports the specified format, otherwise an error is raised.
PyObject *PyIDataObject::QueryGetData(PyObject *self, PyObject *args)
{
	IDataObject *pIDO = GetI(self);
	if ( pIDO == NULL )
		return NULL;
	FORMATETC formatetc;
	PyObject *obpformatetc;
	// @pyparm <o PyFORMATETC>|pformatetc||Tuple representing a FORMATETC struct describing how the data should be returned
	if ( !PyArg_ParseTuple(args, "O:QueryGetData", &obpformatetc) )
		return NULL;
	BOOL bPythonIsHappy = TRUE;
	if (bPythonIsHappy && !PyObject_AsFORMATETC( obpformatetc, &formatetc )) bPythonIsHappy = FALSE;
	if (!bPythonIsHappy) return NULL;
	HRESULT hr;
	PY_INTERFACE_PRECALL;
	hr = pIDO->QueryGetData( &formatetc );
	PY_INTERFACE_POSTCALL;

	if ( FAILED(hr) )
		return PyCom_BuildPyException(hr, pIDO, IID_IDataObject );
	Py_INCREF(Py_None);
	return Py_None;

}

// @pymethod <o PyFORMATETC>|PyIDataObject|GetCanonicalFormatEtc|Transforms a FORMATECT data description into a general format that the object supports
PyObject *PyIDataObject::GetCanonicalFormatEtc(PyObject *self, PyObject *args)
{
	IDataObject *pIDO = GetI(self);
	if ( pIDO == NULL )
		return NULL;
	FORMATETC formatectIn;
	PyObject *obpformatectIn;
	// @pyparm <o PyFORMATETC>|pformatectIn||Tuple representing a FORMATETC struct describing how the data should be returned
	if ( !PyArg_ParseTuple(args, "O:GetCanonicalFormatEtc", &obpformatectIn) )
		return NULL;
	BOOL bPythonIsHappy = TRUE;
	if (bPythonIsHappy && !PyObject_AsFORMATETC( obpformatectIn, &formatectIn )) bPythonIsHappy = FALSE;
	if (!bPythonIsHappy) return NULL;
	FORMATETC formatetcOut;
	HRESULT hr;
	PY_INTERFACE_PRECALL;
	hr = pIDO->GetCanonicalFormatEtc( &formatectIn, &formatetcOut );
	PY_INTERFACE_POSTCALL;
	if ( FAILED(hr) )
		return PyCom_BuildPyException(hr, pIDO, IID_IDataObject );
	return PyObject_FromFORMATETC(&formatetcOut);
}

// @pymethod |PyIDataObject|SetData|Sets the data that the object will return.
PyObject *PyIDataObject::SetData(PyObject *self, PyObject *args)
{
	IDataObject *pIDO = GetI(self);
	if ( pIDO == NULL )
		return NULL;
	FORMATETC formatetc;
	PyObject *obpformatetc;
	// @pyparm <o PyFORMATETC>|pformatetc||Tuple representing a FORMATETC struct describing the type of data to be set
	PyObject *obmedium;
	PySTGMEDIUM *pymedium;
	// @pyparm <o PySTGMEDIUM>|pmedium||The data to be placed in the object
	// @pyparm boolean|fRelease||If True, transfers ownership of the data to the object.  If False, caller is responsible for releasing the STGMEDIUM.
	BOOL fRelease;
	if ( !PyArg_ParseTuple(args, "OOi:SetData", &obpformatetc, &obmedium, &fRelease) )
		return NULL;
	BOOL bPythonIsHappy = TRUE;
	if (bPythonIsHappy && !PyObject_AsFORMATETC( obpformatetc, &formatetc )) bPythonIsHappy = FALSE;
	if (bPythonIsHappy && !PyObject_AsPySTGMEDIUM( obmedium, &pymedium )) bPythonIsHappy = FALSE;
	if (!bPythonIsHappy) return NULL;
	HRESULT hr;
	PY_INTERFACE_PRECALL;
	hr = pIDO->SetData( &formatetc, &pymedium->medium, fRelease );
	PY_INTERFACE_POSTCALL;
	if (fRelease)
		pymedium->DropOwnership();
	if ( FAILED(hr) )
		return PyCom_BuildPyException(hr, pIDO, IID_IDataObject );
	Py_INCREF(Py_None);
	return Py_None;
}

// @pymethod <o PyIEnumFORMATETC>|PyIDataObject|EnumFormatEtc|Returns an enumerator to list the data formats that the object supports.
PyObject *PyIDataObject::EnumFormatEtc(PyObject *self, PyObject *args)
{
	IDataObject *pIDO = GetI(self);
	if ( pIDO == NULL )
		return NULL;
	// @pyparm int|dwDirection|DATADIR_GET|Indicates whether to return formats that can be queried or set (pythoncom.DATADIR_GET or DATADIR_SET)
	DWORD dwDirection = DATADIR_GET;
	IEnumFORMATETC * ppenumFormatEtc;
	if ( !PyArg_ParseTuple(args, "|l:EnumFormatEtc", &dwDirection) )
		return NULL;
	HRESULT hr;
	PY_INTERFACE_PRECALL;
	hr = pIDO->EnumFormatEtc( dwDirection, &ppenumFormatEtc );
	PY_INTERFACE_POSTCALL;

	if ( FAILED(hr) )
		return PyCom_BuildPyException(hr, pIDO, IID_IDataObject );
	return PyCom_PyObjectFromIUnknown(ppenumFormatEtc, IID_IEnumFORMATETC, FALSE);
}

// @pymethod int|PyIDataObject|DAdvise|Connects the object to an interface that will receive notifications when its data changes
// @rdesc Returns a unique number that is used to identify the connection
PyObject *PyIDataObject::DAdvise(PyObject *self, PyObject *args)
{
	IDataObject *pIDO = GetI(self);
	if ( pIDO == NULL )
		return NULL;
	FORMATETC formatetc;
	PyObject *obpformatetc;
	// @pyparm <o PyFORMATETC>|pformatetc||Defines the type of data for which the sink will receive notifications.
	// @pyparm int|advf||Combination of values from ADVF enum. (which currently do not appear in any of the constants modules!)
	// @pyparm <o PyIAdviseSink>|pAdvSink||Currently this interface is not wrapped.
	PyObject *obpAdvSink;
	DWORD advf;
	IAdviseSink *pAdvSink;
	if ( !PyArg_ParseTuple(args, "OlO:DAdvise", &obpformatetc, &advf, &obpAdvSink) )
		return NULL;
	BOOL bPythonIsHappy = TRUE;
	if (bPythonIsHappy && !PyObject_AsFORMATETC( obpformatetc, &formatetc )) bPythonIsHappy = FALSE;
	if (bPythonIsHappy && !PyCom_InterfaceFromPyInstanceOrObject(obpAdvSink, IID_IAdviseSink, (void **)&pAdvSink, TRUE /* bNoneOK */))
		 bPythonIsHappy = FALSE;
	if (!bPythonIsHappy) return NULL;
	DWORD dwConnection;
	HRESULT hr;
	PY_INTERFACE_PRECALL;
	hr = pIDO->DAdvise( &formatetc, advf, pAdvSink, &dwConnection );
	PY_INTERFACE_POSTCALL;
	if (pAdvSink) pAdvSink->Release();
	if ( FAILED(hr) )
		return PyCom_BuildPyException(hr, pIDO, IID_IDataObject );
	return PyInt_FromLong(dwConnection);
}

// @pymethod |PyIDataObject|DUnadvise|Disconnects a notification sink.
PyObject *PyIDataObject::DUnadvise(PyObject *self, PyObject *args)
{
	IDataObject *pIDO = GetI(self);
	if ( pIDO == NULL )
		return NULL;
	// @pyparm int|dwConnection||Identifier of the connection as returned by DAdvise.
	DWORD dwConnection;
	if ( !PyArg_ParseTuple(args, "l:DUnadvise", &dwConnection) )
		return NULL;
	HRESULT hr;
	PY_INTERFACE_PRECALL;
	hr = pIDO->DUnadvise( dwConnection );
	PY_INTERFACE_POSTCALL;
	if ( FAILED(hr) )
		return PyCom_BuildPyException(hr, pIDO, IID_IDataObject );
	Py_INCREF(Py_None);
	return Py_None;
}

// @pymethod <o PyIEnumSTATDATA>|PyIDataObject|EnumDAdvise|Creates an enumerator to list connected notification sinks.
PyObject *PyIDataObject::EnumDAdvise(PyObject *self, PyObject *args)
{
	IDataObject *pIDO = GetI(self);
	if ( pIDO == NULL )
		return NULL;
	IEnumSTATDATA *ppenumAdvise;
	if ( !PyArg_ParseTuple(args, ":EnumDAdvise") )
		return NULL;
	HRESULT hr;
	PY_INTERFACE_PRECALL;
	hr = pIDO->EnumDAdvise( &ppenumAdvise );
	PY_INTERFACE_POSTCALL;
	if ( FAILED(hr) )
		return PyCom_BuildPyException(hr, pIDO, IID_IDataObject );
	return PyCom_PyObjectFromIUnknown(ppenumAdvise, IID_IEnumSTATDATA, FALSE);
}

// @object PyIDataObject|Used to transfer data in various formats throughout the shell
// @comm Can be enumerated to return a series of <o PyFORMATETC> describing the formats
//   that the object can render.
static struct PyMethodDef PyIDataObject_methods[] =
{
	{ "GetData", PyIDataObject::GetData, 1 }, // @pymeth GetData|Retrieves data from the object in specified format
	{ "GetDataHere", PyIDataObject::GetDataHere, 1 }, // @pymeth GetDataHere|Returns a copy of the object's data in specified format
	{ "QueryGetData", PyIDataObject::QueryGetData, 1 }, // @pymeth QueryGetData|Checks if the object supports returning data in a particular format
	{ "GetCanonicalFormatEtc", PyIDataObject::GetCanonicalFormatEtc, 1 }, // @pymeth GetCanonicalFormatEtc|Transforms a FORMATECT data description into a general format that the object supports
	{ "SetData", PyIDataObject::SetData, 1 }, // @pymeth SetData|Sets the data that the object will return.
	{ "EnumFormatEtc", PyIDataObject::EnumFormatEtc, 1 }, // @pymeth EnumFormatEtc|Returns an enumerator to list the data formats that the object supports.
	{ "DAdvise", PyIDataObject::DAdvise, 1 }, // @pymeth DAdvise|Connects the object to an interface that will receive notifications when its data changes
	{ "DUnadvise", PyIDataObject::DUnadvise, 1 }, // @pymeth DUnadvise|Disconnects a notification sink.
	{ "EnumDAdvise", PyIDataObject::EnumDAdvise, 1 }, // @pymeth EnumDAdvise|Creates an enumerator to list connected notification sinks.
	{ NULL }
};

PyComEnumProviderTypeObject PyIDataObject::type("PyIDataObject",
		&PyIUnknown::type,
		sizeof(PyIDataObject),
		PyIDataObject_methods,
		GET_PYCOM_CTOR(PyIDataObject),
		"EnumFormatEtc");
// ---------------------------------------------------
//
// Gateway Implementation
STDMETHODIMP PyGDataObject::GetData(
		/* [unique][in] */ FORMATETC * pformatetcIn,
		/* [out] */ STGMEDIUM * pmedium)
{
	static const char *method_name = "GetData";
	if (!pmedium)
		return E_POINTER;
	PY_GATEWAY_METHOD;
	PyObject *obpformatetcIn = PyObject_FromFORMATETC(pformatetcIn);
	if (obpformatetcIn==NULL) return MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	PyObject *result;
	HRESULT hr=InvokeViaPolicy("GetData", &result, "(O)", obpformatetcIn);
	Py_DECREF(obpformatetcIn);
	if (FAILED(hr)) return hr;
	// Process the Python results, and convert back to the real params
	if (PySTGMEDIUM_Check(result)) {
		PySTGMEDIUM *pym = (PySTGMEDIUM *)result;
		// Documentation says pmedium is 'out' - generally it will have empty
		// data, but not always.
		memset(pmedium, 0, sizeof(*pmedium));
		pym->CopyTo(pmedium);
	}
	hr = MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	Py_DECREF(result);
	return hr;
}

STDMETHODIMP PyGDataObject::GetDataHere(
		/* [unique][in] */ FORMATETC * pformatetc,
		/* [out][in] */ STGMEDIUM * pmedium)
{
	static const char *method_name = "GetDataHere";
	PY_GATEWAY_METHOD;
	PyObject *obpformatetc = PyObject_FromFORMATETC(pformatetc);
	if (obpformatetc==NULL) return MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	PyObject *result;
	HRESULT hr=InvokeViaPolicy(method_name, &result, "(O)", obpformatetc);
	Py_DECREF(obpformatetc);
	if (FAILED(hr)) return hr;
	// Process the Python results, and convert back to the real params
	if (PySTGMEDIUM_Check(result)) {
		PySTGMEDIUM *pym = (PySTGMEDIUM *)result;
		memcpy(pmedium, &pym->medium, sizeof(STGMEDIUM));
		pym->DropOwnership();
	}
	hr = MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	Py_DECREF(result);
	return hr;
}

STDMETHODIMP PyGDataObject::QueryGetData(
		/* [unique][in] */ FORMATETC * pformatetc)
{
	static const char *method_name = "QueryGetData";
	PY_GATEWAY_METHOD;
	PyObject *obpformatetc = PyObject_FromFORMATETC(pformatetc);
	if (obpformatetc==NULL) return MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	HRESULT hr=InvokeViaPolicy(method_name, NULL, "(O)", obpformatetc);
	Py_DECREF(obpformatetc);
	return hr;
}

STDMETHODIMP PyGDataObject::GetCanonicalFormatEtc(
		/* [unique][in] */ FORMATETC * pformatectIn,
		/* [out] */ FORMATETC * pformatetcOut)
{
	static const char *method_name = "GetCanonicalFormatEtc";
	PY_GATEWAY_METHOD;
	PyObject *obpformatectIn = PyObject_FromFORMATETC(pformatectIn);
	if (obpformatectIn==NULL) return MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	PyObject *result;
	HRESULT hr=InvokeViaPolicy(method_name, &result, "(O)", obpformatectIn);
	Py_DECREF(obpformatectIn);
	if (FAILED(hr)) return hr;
	// Process the Python results, and convert back to the real params
	PyObject_AsFORMATETC(result, pformatetcOut);
	Py_DECREF(result);
	return hr;
}

STDMETHODIMP PyGDataObject::SetData(
		/* [unique][in] */ FORMATETC * pformatetc,
		/* [unique][in] */ STGMEDIUM * pmedium,
		/* [in] */ BOOL fRelease)
{
	static const char *method_name = "SetData";
	PY_GATEWAY_METHOD;
	PyObject *obpformatetc = PyObject_FromFORMATETC(pformatetc);
	if (obpformatetc==NULL) return MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	PySTGMEDIUM *obmedium = PyObject_FromSTGMEDIUM(pmedium);
	if (obmedium==NULL) return MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
        // PySTGMEDIUM should be the exact same pointer as PyObject
        assert((void *)(PyObject *)obmedium==(void *)obmedium);
	HRESULT hr=InvokeViaPolicy(method_name, NULL, "OOi", obpformatetc, (PyObject *)obmedium, fRelease);
	if (!fRelease)
		obmedium->DropOwnership();
	Py_DECREF(obpformatetc);
	Py_DECREF(obmedium);
	return hr;
}

STDMETHODIMP PyGDataObject::EnumFormatEtc(
		/* [in] */ DWORD dwDirection,
		/* [out] */ IEnumFORMATETC ** ppenumFormatEtc)
{
	static const char *method_name = "EnumFormatEtc";
	PY_GATEWAY_METHOD;
	PyObject *result;
	HRESULT hr=InvokeViaPolicy(method_name, &result, "l", dwDirection);
	if (FAILED(hr)) return hr;
	// Process the Python results, and convert back to the real params
	PyObject *obppenumFormatEtc;
	if (!PyArg_Parse(result, "O" , &obppenumFormatEtc)) return MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	BOOL bPythonIsHappy = TRUE;
	if (bPythonIsHappy && !PyCom_InterfaceFromPyInstanceOrObject(obppenumFormatEtc, IID_IEnumFORMATETC, (void **)ppenumFormatEtc, TRUE /* bNoneOK */))
		 bPythonIsHappy = FALSE;
	if (!bPythonIsHappy) hr = MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	Py_DECREF(result);
	return hr;
}

STDMETHODIMP PyGDataObject::DAdvise(
		/* [in] */ FORMATETC * pformatetc,
		/* [in] */ DWORD advf,
		/* [unique][in] */ IAdviseSink * pAdvSink,
		/* [out] */ DWORD * pdwConnection)
{
	static const char *method_name = "DAdvise";
	PY_GATEWAY_METHOD;
	PyObject *obpformatetc = PyObject_FromFORMATETC(pformatetc);
	if (obpformatetc==NULL) return MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	PyObject *obpAdvSink;
	obpAdvSink = PyCom_PyObjectFromIUnknown(pAdvSink, IID_IAdviseSink, TRUE);
	PyObject *result;
	HRESULT hr=InvokeViaPolicy(method_name, &result, "OlO", obpformatetc, advf, obpAdvSink);
	Py_DECREF(obpformatetc);
	Py_XDECREF(obpAdvSink);
	if (FAILED(hr)) return hr;
	*pdwConnection = PyInt_AsLong(result);
	Py_DECREF(result);
	return hr;
}

STDMETHODIMP PyGDataObject::DUnadvise(
		/* [in] */ DWORD dwConnection)
{
	PY_GATEWAY_METHOD;
	HRESULT hr=InvokeViaPolicy("DUnadvise", NULL, "l", dwConnection);
	return hr;
}

STDMETHODIMP PyGDataObject::EnumDAdvise(
		/* [out] */ IEnumSTATDATA ** ppenumAdvise)
{
	static const char *method_name = "EnumDAdvise";
	PY_GATEWAY_METHOD;
	PyObject *result;
	HRESULT hr=InvokeViaPolicy(method_name, &result);
	if (FAILED(hr)) return hr;
	// Process the Python results, and convert back to the real params
	PyObject *obppenumAdvise;
	if (!PyArg_Parse(result, "O" , &obppenumAdvise)) return MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	BOOL bPythonIsHappy = TRUE;
	if (bPythonIsHappy && !PyCom_InterfaceFromPyInstanceOrObject(obppenumAdvise, IID_IEnumSTATDATA, (void **)ppenumAdvise, TRUE /* bNoneOK */))
		 bPythonIsHappy = FALSE;
	if (!bPythonIsHappy) hr = MAKE_PYCOM_GATEWAY_FAILURE_CODE(method_name);
	Py_DECREF(result);
	return hr;
}

redpajama_set_name: RedPajamaGithub


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Dissertation - Abstract
Dissertation - Conclusion
Dissertation - Discussion
Dissertation - Introduction
Dissertation - Literature
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Home / Term Paper / Challenge, Not Inevitability: Alzheimer's in Seniors, Term Paper Example
Challenge, Not Inevitability: Alzheimer's in Seniors, Term Paper Example
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Unfortunately, it is typical to think of advanced age as a time in life in which development ceases, or decreases to an imperceptible degree. More common, in fact, is the assumption that senior citizens regress mentally; until the late 19th century, it has largely been assumed that senility occurs to some degree with age, and aging itself is viewed as a degenerative process (Jacyna, Casper 115). Added to this scenario is the relatively modern awareness of Alzheimer's disease, usually affecting the elderly and often having severe impacts on the individual's mental processes. With Alzheimer's in place, modern attitudes regarding any potential for development in senior citizens is sadly reinforced in a negative way. Nonetheless, and as evidence increasingly suggests, there is no definitive correlation between advanced age and reduced mental development. Moreover, even Alzheimer's is seen as subject to influences countering its harmful effects. If seniors citizens face more dire potentials in diminished mental growth, and if this is exacerbated by Alzheimer's, it appears that such processes are not inevitable. Actual mental growth and development in the elderly is most definitely possible, even as science seeks to address the biological factor of Alzheimer's as further impeding such development.
As noted, associations between the elderly and lessened brain functioning have been in place for long centuries. The view is particularly prominent in Western cultures, and even researchers have traditionally shared in the belief that, with age, mental development radically declines (Hockenbury, Hockenbury 274). This became so common in past eras that expectations of senility, or even what was classified as "dementia," were anticipated as inevitable after individuals reached a certain age. It would not be until 1907, when a Dr. Alois Alzheimer examined the brain of a 51 year-old woman suffering extreme mental problems, that the actual disease would be identified. Alzheimer discovered, during an autopsy of the patient, that a significant number of brain cells were gone, and in their place were growths and plaques (Brill 38). What is particularly notable here is that this initial case was so young, which indicates how the onset of Alzheimer's may well occur in middle age. This then indicates age itself as a questionable causal agent of the disease.
Since Alzheimer's breakthrough, massive research has gone into exploring just how this disease develops, even as treatments are devised to forestall or eliminate it. It is established that the primary differences between seniors with Alzheimer's and those not suffering from the disease are largely biological in nature. When Alzheimer's is present, abnormal deposits of proteins are detected in the brain. These deposits typically create Neurofibrillary Tangles, which are masses of proteins that interfere with neural processes, cause inflammations in brain regions, and break down synaptic pathways (Steinberg, Bornstein, Vandell, & Rook 583). The patient, consequently, displays all the symptoms classically associated with advanced senility. Memories are disjointed, and in no predictable manner; the Alzheimer's victim may recall with perfect clarity an event in the distant past and be unable to remember their address. Persons known to them all their lives are suddenly strangers, just as full recognition may reoccur. In simple terms, the disease "short-circuits" the brain, and in ways and to degrees varying with each specific case. What is know, however, is that it does not abate, and the degenerative process usually worsens.
While no specific cause has yet been identified for Alzheimer's, it is widely felt that multiple factors generate these brain abnormalities. Certainly, high-risk populations have been established, and in ways not entirely reflecting advanced age. For example, head injuries earlier in life increases the risk of the disease, and it has been found that there is a hereditary component; the person with a parent suffering from Alzheimer's is twice to four times as likely to develop it as well. Then, a mutation of the gene apolipoprotein (APOE) is found in over half of all Alzheimer's patients, as opposed to approximately 20 percent of non-afflicted adults (Steinberg et al 583). Other considerations are studied as well. In addressing Alzheimer's, or any notion of deteriorating mental ability with age, medicine and science has steadily worked to both understand and counter social and environmental structures defying progress. More exactly, as research in the mid-20th century revealed, there are no inevitable brain matter losses with advanced age, and this set science on a more expansive path. It began to seem that loss of brain function in older adults was largely a matter of self-fulfilling prophecy, and that cultural expectations of such loss served to create precisely that. The elderly were not so much stigmatized by society because they were senile; instead, they were senile because they were stigmatized (Jacyna, Casper 115). In a significant and extensive study performed in the 1990s, for example, strong evidence was found that perception actually dictates mental performance. Samplings of young and older people were taken from several cultures, notably the U.S. and China, as these societies vary greatly in how they regard the elderly. A range of memory tests were assigned, and the results uniformly indicated that, in the Chinese culture, performance was consistently high among the elderly; conversely, American scores were low, conforming to the lesser status American society affords its senior population (Hockenbury, Hockenbury 274).
No serious gerontologist or scientist dismissed the risk factor inherent with age, but there was a growing ideology determined to maintain a better perspective regarding that risk.
There can be no underestimating of just how cultural views impact on age and mental ability, simply because of how pervasive the attitudes have been, and for so long. Though largely discredited today, 19th century neurologist George Miller Beard ultimately set out what would become the American ideology of the subject when he published his work absolutely asserting that age brings about "feeble" thinking. A further cultural legacy of this work, which remained dominant well into the mid 19th century, was that moral lapses predictably followed these mental failings (Jacyna, Casper 111). The senior citizen was presented as an inevitably declining individual, and in all behaviors and capabilities. Modern thinking, thankfully, dismisses most of this rhetoric. Some degree of lessened mental functioning does seem to be correlated with advanced age. Nonetheless, increasing research indicates that much of this may be a result of cultural and/or environmental restrictions or expectations. For example, in studies done on a wide variety of animals, there are frequently dramatic increases in brain growth and synaptic connections as age increases. These increases, moreover, relate directly to enriched environments and alterations in external stimuli (Hockenbury, Hockenbury 84). As has been noticed with Alzheimer's patients, in fact, this may be a key component in countering any deterioration due to aging. With the disease itself, stimulation must be carefully applied; consistency and moderation are the goals, as undue excitement easily disorients the sufferer (Soukup 114). Nonetheless, and as innumerable active senior citizens exemplify, the mind kept interested and alert in advancing age seems to be the mind more likely to enjoy continued development. Alzheimer's remains a distinct disease, yet it may be that, in uncovering treatments for it, science establishes modes of approach that encourage all senior brain activity.
It is likely that stigmas in place for long centuries are easily eradicated, and a great deal of Western thinking seems to still hold that age brings about an inevitable decay of mental processes. The tragedy of Alzheimer's tends to reinforce this, as the disease typically affects the elderly and is characterized by symptoms associated with advanced senility. What is changing, however, is that culture itself is being recognized as a significant component in these equations, and one that may well go to assisting in Alzheimer's treatments. Simply, increasing amounts of evidence suggest that advanced age and lack of development are not synonymous, just as a biological understanding of Alzheimer's proves that such damage is frequently, and literally, a disease. With more research, then, it may be discovered that other, minor forms of Alzheimer's generate the weaknesses associated with old age, just as it is now believed that cultural values do the same. What matters, of course, is that all work being done points to a positive conclusion: mental growth and development in the elderly is most definitely possible, even as science seeks to deal with the biological factor of Alzheimer's as impeding this development.
Brill, M. T. (2005). Alzheimer's Disease. Tarrytown: Marshall Cavendish, 2005. Print.
Jacyna, L. S., & Casper, S. T. The Neurological Patient in History. Rochester: University of Rochester Press, 2012. Print.
Hockenbury, D. H., & Hockenbury, S. E. Psychology, 3rd Ed. New York: Worth Publishers, 2002. Print.
Steinberg, L., Bornstein, M. H., Vandell, D. L., & Rook, K. S. Lifespan Development: Infancy Through Adulthood. Belmont: Cengage Learning, 2010. Print.
Soukup, J. E. Alzheimer's Disease: A Guide to Diagnosis, Treatment, and Management. Westport: Greenwood Publishing Group, 1996. Print.
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text:
NIH study uncovers details of early stages in muscle formation and regeneration
NICHD Archive
Note: Information on this page was accurate at the time of publication.
This page is no longer being updated.
Mouse study findings may offer clues for understanding cell fusion
To form muscle fibers, masses of cells merge to form long tubes with many cell nuclei (above). Recent research reveals two distinct stages in this process. First, proteins on the outside of the cells (shown as spikes in A) promote the fusion of the cell membranes. The blue squares in B and C represent proteins inside the cells that facilitate the development of a pore between them, so their contents can merge. This process of cell fusion is a basic part of the biology of muscle cell fusion and of several other types of cells as well.
Researchers at the National Institutes of Health have identified proteins that allow muscle cells in mice to form from the fusion of the early stage cells that give rise to the muscle cells.
The findings have implications for understanding how to repair and rehabilitate muscle tissue and to understanding other processes involving cell fusion, such as when a sperm fertilizes an egg, when viruses infect cells, or when specialized cells called osteoclasts dissolve and assimilate bone tissue in order to repair and maintain bones.
Their findings were published online in the Journal of Cell Biology.
"Through a process that starts with these progenitor cells, the body forms tissue that accounts for about one-third of its total weight," said the study's senior author, Leonid V. Chernomordik, Ph.D., of the Section on Membrane Biology at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the NIH institute where the research was conducted. "Our study provides the first look at the very early stages of this fusion process."
Dr. Chernomordik conducted the study along with researchers at NICHD (Evgenia Leikina, D.V.M.,; Kamram. Melikov, Ph.D.; Samristha Sanyal, Ph.D.; Santosh Verma, Bokke Eun, Ph.D.; Claudia Gebert, D.V.M., Ph.D.; Karl Pfeifer, Ph.D., and Vladimir.A. Lizunov, Ph.D.) and at Tel Aviv University, in Israel (Michael M. Kozlov, Ph.D.).
Muscle cells originate from precursor cells known as myoblasts. Myoblasts fuse to form a single long tubular cell called a myocyte (a muscle fiber). Muscle tissue is composed of large collections of these fibers. The fusion of myoblasts into muscle fibers takes place early in fetal development. With exercise and throughout a person's life, the process is repeated to form new muscle mass and repair old or damaged muscle.
It takes many hours for cells to prepare for fusion, but the fusion process itself is very rapid. To study myoblast fusion, the researchers first blocked the start of the fusion process with a chemical. Ordinarily, the mouse myoblasts the researchers worked with fuse at varied intervals. By blocking fusion, and then lifting the block, the researchers were able to synchronize fusion in a large number of cells, making the process easier to study.
The researchers identified the two distinct stages of cell fusion and the essential proteins that facilitate these stages.
In the first stage, two myoblasts meet, and proteins on cell surface membranes cause the membranes to meld. In the second stage, a pore opens between the cells and their contents merge. This second step is guided by proteins inside the cells.
The work identifies two cell surface proteins that act at the start of myoblast fusion. These proteins belong to a large family of proteins called annexins. Annexins are also known to play a role in membrane repair and in inflammation.
The researchers identified the protein dynamin, found inside the cell, as essential to the second stage of the cell fusion process.
"Dynamin also has an unexplained link to certain rare and poorly understood myopathies -- disorders characterized by underdeveloped muscles," said Dr. Chernomordik. "We hope that further examination of the role of dynamin in cell fusion will lead to a greater understanding of these conditions."
The research article upon which the release is based can be downloaded free of charge at https://rupress.org/jcb/article/200/1/3/37111/The-two-stages-of-cell-fusion .
About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): The NICHD sponsors research on development, before and after birth; maternal, child, and family health; reproductive biology and population issues; and medical rehabilitation. For more information, visit the Institute's website at http://www.nichd.nih.gov/.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.
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Content OwnerOffice of CommunicationsLast Reviewed Date 1/8/2013


Ali Asgar is one of the popular comedians in India. He has an amazing sense of humor. He is a multi talented personality as he did different roles in both television serials and Bollywood movies in the past as well as he is also playing various characters these days. Slowly but steadily he settled his feet in the B-town, although he struggled a lot in his starting days of career. He is now very much popular in B-town. But there are still a lot of people who do not know about him properly and they are desperate to know about comedian Ali Asgar biography in detail. Ali Asgar wiki unveils all his personal life secrets as well as his professional career too.
Ali Asgar belongs to a middle class family background. He is a Muslim by religion. Ali Asgar father was working in a private company in Mumbai and his mother is a housewife. Ali Asgar age is 47 years and his birthplace is Mumbai, India. He completed his schooling from a private school in Mumbai, India. After schooling, he took a lot of interest in hotel management course. Therefore, he did graduation in the catering field from the Institute of Hotel Management in Dadat, Mumbai.
Ali Asgar date of birth is 25 July, 1966 and he used to celebrate his birthday with his family members. He also got an from abroad to join a hotel in the beverage and food department after the completion of his graduation. But he refused that offer as they demanded his presence in abroad for 10 years. Ali Asgar real name is Ali Azgar. His parents used to call him "Ali". Ali Asgar height is 5 feet and 3 inches. Read more about Ali Asgar personal life in the next paragraphs.
Comedian Ali Asgar started his career as a television artist. Ali Asgar first TV serial was "Ek Do Teen Chaar" which was aired on "Doordarshan" in 1987. It was a children's program and he gained a lot of popularity from this television serial. Then he acted in a television serial "Dil Vil Pyar Vyar" with Swapnil Joshi. But he got fame and popularity through a television serial "Kahaani Ghar Ghar Ki" which was aired on Star Plus.
People also spread rumors about Ali Asgar love affairs. They link his name to various daily soap artists. But he refused all these rumors. Then, he acted in a television serial "Kutumb" on Sony TV in 2001. He also appeared in a famous television show "Hum Paanch Season 2" on Zee TV in 2006. Ali Asgar was the winner of a comedy show "Comedy Circus 1" with Kashif Khan in 2007. This show was aired on Sony TV. Continue reading this article to know more about Ali Asgar wiki.
Ali Asgar is a well known comedian and actor in India. He appeared in so many Bollywood films. Ali Asgar first movie was "Khalnayak" in 1993. This movie was a blockbuster. Then he appeared in two Bollywood movies "Josh" and "Joru Ka Ghulam" in a supporting role in the year 2000. He also appeared in a supporting role in many popular movies like "Raaz" in 2002, "Shaadi No. 1" in 2005, "Partner" in 2007 and "Sunday" in 2008. At that time, he got so much popularity that so many girls want to date with him.
The media also made gossips about Ali Asgar girlfriend name. But he did not bother about these gossips and totally focussed on his career. Later, he also acted in the movies "Do Knot Disturb" in 2009 and "Tees Maar Khan" in 2010 in a supporting role. He also played the lead role in a popular television serial "FIR" in 2009 which was aired on SAB TV. Later, he left this show and become the host of a reality show "Shaadi 30 Million Ki" on NDTV Imagine in 2011. People also made gossips on Ali Asgar and Sakshi Tanwar relationship in 2012.
Ali Asgar is a renowned face of Indian television. Everyone wants to know about Ali Asgar marital status. There are a lot of people who do not know that he is married and those who know, they want to know about Ali Asgar love story in detail.
Well, Ali Asgar is married and Ali Asgar wife name is Siddika Asgar. He used to spend the most of his time with his wife Siddika Asgar after the shoot. The wedding date of Ali Asgar was 17 November, 2005. After two years of marriage, Ali Asgar wife Siddika gave birth to a beautiful kid. His wife Siddika got pregnant again in 2009 and gave birth to a child. Now, Ali Asgar is the father of two children. Ali Asgar and his wife Siddika Asgar lived happily in an apartment in Mumbai. Ali Asgar marriage pics also available on the internet. One can also see Ali Asgar wife pics on various websites.
Ali Asgar also won the title of a comedy show "Comedy Circus Ke Taansen" with popular comedian Kapil Sharma in 2011. This show was aired on Sony TV. Currently, he is playing the lead role in a television serial "Jeannie Aur Juju" on SAB TV. He also appears in "Comedy Nights with Kapil" on the Colors Entertainmment Channel, which is a very popular and the most watched television show these days.
Kapil Sharma is the host and the producer of this comedy show. Sumona Chakravarti, Upasana Singh, Kiku Sharda and Chandan Prabhakar are the other artists on this comedy show. Ali Asgar playing the role of "Dadi" in this comedy show. There are so many people who do not know that the real name of Dadi in Comedy Nights with Kapil is Ali Asgar. His performance and superb sense of humor in this comedy show is appreciated by everyone.


The needs of young people became a significant policy concern in the second half of the 20th century when Western European countries realized they needed to develop a long-term strategy that would specifically respond to the needs of youth. This would attempt to not only deal with the issues facing young people as a social group, but also consider youth as a valuable resource that can contribute to the development of European society.
Young people need opportunities to raise their concerns with policy-makers and to discuss and develop youth policy that concerns them and their needs, at the local, national and European level. The needs and expectations of young people across Europe should be considered.
Though different actions have been encouraged at European and national levels, involving the European Commission, Member States, youth councils and the European Youth Forum, on the whole youngsters feel increasingly distanced from the policies which affect them most.


Meetup en Madrid: Comunicación transversal. Telefonía para ventas. Nueva App.
Inicio Events Meetup in Madrid: Transversal communication. Telephony for sales. New App.
Do you want to know ZOHO in its most genuine form?
Then you have to come and see us next Tuesday, January 30, in Madrid. We'll talk about the ZOHO community, who uses ZOHO? how do you use it? what are the last news in ZOHO? We will enjoy a full day of activity where we will see how to get the most out of our tools.
We will explain how to increase your sales by integrating ZOHO CRM, DESK, RECRUIT and telephony to be more efficient and achieve your goals.
Oh! and we will have a very special surprise, we will present the new ZOHO APP, so you know, if you want to be among the first to know it, you have to come.
The best way to be up to date with ZOHO is to be part of ZOHO COMMUNITY, we are waiting you at IMF Business School, next to the Atocha station.
We have limited assistance, book your entry by clicking here!


MUMBAI: Next month in the lead-up to the mid-term elections in the US on 7 November, the BBC will have a USA Direct season.
This will feature news coverage, interviews and documentaries looking at American society, culture, economics, and politics. In addition some of BBC World's regular programmes such as flagship interview programme HARDtalk, technology weekly Click and the interactive multimedia discussion programme Have Your Say, will offer an assessment of 'the state of the nation', asking has the US reached its peak as the world's only superpower?
World Business Report will be reporting on the topical issue of immigration and the role of immigrants in the work force. A special It's My Country Too airs on 21 October at 7:40 pm. It's five years since 9/11, and the US is a changed country, especially for Muslims. Islam is one of the fastest-growing religions in the US, yet one in four Americans regard Muslims living among them with suspicion. As part of the USA Direct season, It's My Country Too follows Salman Ahmed, the founding member of successful rock band Junoon, as he explores what it means to be an American Muslim. Salman talks to taxi drivers, students and law reform campaigners, including a mother whose desperate search for her Muslim son after 9/11 turned her into a political activist.
The World Debate Advancing Sands: Deserts and Migration airs on 14 October at 5:40 pm. A dust bowl the size of the US threatens our world. The UN says that desertification is forcing 100 million people to leave their homes. Marking the UN Year Of Deserts and Desertification, The World Debate comes from the headquarters of the World Conservation Union in Switzerland. Six experts will take questions from viewers on the Internet on why so little has been done to halt the degradation of fertile lands and what can now be done to ensure that tens of millions more are not forced to leave their villages.
Is A Free Media Essential For Development? airs on 28 October at 5:40 pm. 'Communications for Development' is a new and expanding field, which places the media at the heart of international development efforts. At its basic level it's about using the media, for instance, to encourage people to wash their hands before eating or to use condoms - simple, non-controversial campaigns that can potentially save millions of lives. However increasingly the media's role in promoting good governance is being recognised by donor countries, and not always welcomed by the governments of some developing countries. Many place restrictions on their domestic media, with actual or self-censorship rife.


Community Supported Agriculture (CSA) is a typical farm model in which producers charge at the beginning of the season for a weekly delivery of local vegetables, meat, or eggs fresh from the farm.
In this case, you pay up front for a 12-week season of bread, delivered to a local business near you, baked just hours before you for pick it up each week. All my bread and pizza dough is made with Weisenberger Mill flour, water, salt, and yeast - that's it.


text:
The vexacious divorce of Samuel Foster of Tallahatchie co. Mississippi
Found this one in the newspaper Flag of the Union from Jackson, MS, dated Feb 27 1852. Not related to my Foster line so far as I know, but one of those peculiar genealogical things that will be of great interest to any descendants.
"Foster, a respectable citizen of Tallahatchie county", had married a "quarteroon Indian lady with a hand-some fortune". This first wife had two children from a previous marriage, and she and Samuel Foster had three children together. More than 6 years before this article was written, Samuel and his first wife parted, and lawsuits flew thick and fast between the pair. By 1851, Samuel Foster was anxious to be married again, and his counsel (lawyer) told him that a Decree of Divorce was imminent, and that if he did not hear anything further, that "he might consider that the Divorce had been obtained". Foster went ahead and married a lady from Tippah county.
Well, after the second marriage, he heard back from his lawyer that the divorce DID NOT go through, resulting in Samuel Foster having two wives. The first Mrs. Foster filed an answer allegedly adultery and declared that she could not stay under his roof.
asked Jul 5, 2018 in The Tree House by Jessica Key G2G6 Pilot (254k points)
Classic! Things haven't changed much, have they?
selected Jul 14, 2019 by Rubén Hernández
Thank you, Rubén!
commented Jul 14, 2019 by Pip Sheppard G2G Astronaut (2.5m points)
My oldest known ancestor was julius foster born in 1800 in Mississippi help
asked Jul 20, 2017 in Genealogy Help by anonymous
Huge DNA breakthrough for me! (Fosters, Mississippi)
asked Jun 11, 2019 in The Tree House by Jessica Key G2G6 Pilot (254k points)
dna_confirmation
Need information on Altha Peters and Sam Foster 1800's of Mississippi
asked Jun 24, 2012 in Genealogy Help by anonymous
Was Samuel "Eli" Foster Born at St. Lawrence, York, Yorkshire, England?
asked Jan 10, 2018 in Genealogy Help by Vic Watt G2G6 Pilot (336k points)
Looking for more info on Samuel Cox, died 1890s in Mississippi
asked Jun 2, 2016 in Genealogy Help by anonymous G2G Crew (700 points)
Choctaw Co., Alabama, and died 8 May 1930 in Richton, Perry CO., Mississippi
asked Nov 16, 2021 in Genealogy Help by Penny McKenzie G2G Rookie (130 points)
A resource for ancestors in Lauderdale co., Mississippi
asked May 30, 2018 in The Tree House by Jessica Key G2G6 Pilot (254k points)
Andrew Foster before 1700
asked Dec 24, 2022 in Policy and Style by Chris Strickland G2G3 (3.1k points)
Hello My name is Deborah Foster from California very interested in learning about my Family history.
asked Nov 25, 2022 in Genealogy Help by Deborah Foster G2G Crew (340 points)
Who is the second Hannah Foster of Middletown, CT?
asked Feb 28, 2022 in Genealogy Help by Mike Lints G2G1 (1.8k points)


CVS is setting up a mobile pharmacy in Larchmont after a fire tore through the Ferndale Shopping Center, damaging the store late last year.
A two-alarm fire broke out at Excelsior Cleaners on Boston Post Road in Larchmont at approximately 3 p.m. on Wednesday, Dec. 19. The fire quickly spread through the shopping center, damaging several adjoining buildings, including a CVS, which suffered flood damage.
In response, CVS announced it will be opening up a fully-staffed, mobile pharmacy in front of the store at 1310 Boston Post Road in Larchmont. The pharmacy is expected to be open from 8 a.m. to 9 p.m. on weekdays. It will be open from 8 a.m. to 7 p.m. on Saturdays and from 8 a.m. to 6 p.m. on Sundays.