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'Dangerous' Olofsson scores twice in preseason win over Leafs
Reinhart tallies 3 points; Ristolainen makes preseason debut
by Jourdon LaBarber @jourdonlabarber / Sabres.com
Should Victor Olofsson ever get his own action movie, we officially have a title.
The moniker came courtesy of Sabres coach Ralph Krueger following a 5-3 preseason win over the Toronto Maple Leafs on Saturday in which Olofsson tallied two goals, including the winner with 2:36 remaining in regulation.
"Victor is just permanently dangerous," Krueger said. "He's a shooter, which we saw twice today. In practice we've been watching it. We've seen it in the other games already. He's a threat all the time."
A gut feeling prompted Krueger to put Olofsson on the ice alongside Jack Eichel and Sam Reinhart with the game tied late in regulation. Eichel set the winning goal in motion as the first man in the forecheck, poking the puck free to Reinhart in the corner.
Reinhart, who already had a goal and an assist in the game, delivered an immediate pass to the front of the net. The puck glided past Mitch Marner directly onto the stick of Olofsson, who did the rest.
Video: TOR@BUF: Olofsson takes late lead with second goal
"I think Jack was the first guy on the forecheck," Olofsson said. "He worked the puck out to Sam and I kind of saw him turning around, looking where I was even before he got the puck. He just fed me an unbelievable pass. Luckily, it went it."
Olofsson had previously given the Sabres a 2-1 lead on a power play in the second period, stationing himself in the right circle and burying a one-time feed through the middle from Eichel.
Video: TOR@BUF: Olofsson blasts one-timer for PPG
"I'm just trying to find the open lane there," Olofsson explained. "I know he usually finds those passes through, so I've just got to find that lane. He just fed me a great pass. It kind of went between [Jeff] Skinner's legs there and he just kept it going. I just tried to hit the net."
It was a positive step overall for the 24-year-old winger, who's trying to make the opening-night roster following a promising six-game stint with the Sabres to end last season. He proved to be plenty dangerous in Rochester, leading the Amerks with 30 goals and 63 points while adjusting to the North American ice surface and developing his two-way game.
Olofsson kicked off this season with a standout performance at the Prospects Challenge, where he was leaned on as a leader among the up-and-coming Sabres. He carried that strong early impression into main camp, where he's now appeared in two preseason games.
"I felt a little bit better all over the ice today than last game versus Columbus," he said. "It was a step in the right way for me."
Rivalry renewed
Even in the preseason, the rivalry between the Sabres and Maple Leafs seemed to bring a little bit extra from the KeyBank Center crowd. It made for a fun first impression for Krueger, who coached his first game in Buffalo's home building.
"It's an excellent building," Krueger said. "You can really feel the fans. I know when we have a full house, we're going to get this place rocking. It's an excellent atmosphere. I love working in the building. You can feel the spirit already."
Video: Ralph Krueger Postgame (9/21/19)
It helped that the two teams delivered a back-and-forth affair that ultimately ended in a Buffalo win. The Sabres and Maple Leafs traded goals throughout the contest, beginning when John Tavares and Reinhart scored just 2:46 apart in the first period.
Olofsson and Pierre Engvall traded goals in the second period, sending the teams into the final intermission tied with two goals apiece. Jimmy Vesey put the Sabres ahead once again on a breakaway in the third, sprung free by a long stretch pass from Reinhart, but Trevor Moore answered with his own goal 61 seconds later.
Video: TOR@BUF: Vesey roofs wrister on breakaway
C.J. Smith capped the scoring with an empty-net goal after Olofsson tallied the winner.
"We're all competitors here," Eichel said. "You've got to want to win every time you go on the ice. No different preseason, regular season, whatever. We're all trying to get better here and prepare ourselves for the season. I thought we did some good things tonight."
Risto's debut
It wouldn't be a Sabres-Leafs game without some theatrics from Rasmus Ristolainen, who made his preseason debut after a minor injury held him out of the team's first two exhibition games.
Ristolainen drew the Maple Leafs' ire with an open-ice hit on defenseman Tyson Barrie in the third period, which he explained afterward.
"I haven't seen the hit," Ristolainen said. "He was coming down the middle, he didn't keep his head up. I hit him. He was alright. He played the shift after so, all good."
Ristolainen finished the game with 21:38 of ice time, second on the team to fellow defenseman Colin Miller.
"Risto had some aches and pains at the beginning of camp," Krueger said. "They're all gone. He's feeling healthy and it was good to see him in action. He was definitely a huge presence for us out there tonight. It's good to have him on board in every single way."
Krueger will spend the next 24 hours making decisions on his roster with Amerks camp set to begin on Monday.
"Tonight's going to be a big night," he said. "We've had 10 unbelievable days of intensity here. In the next 24 hours, we're going to be making some big moves. Rochester's camp starts on Monday. They have games starting Thursday. We need to make this split.
"It's been a real pleasure to have this whole group here. Everybody's been on board and we've worked really hard. The players who will be going down to Rochester have helped to push the players that will remain here to really work for their spots and for their place. Both our groups have had such a high level of training. I've been really pleased with that. We're going to have two good hockey clubs here."
The Sabres host the Columbus Blue Jackets in their penultimate preseason game on Wednesday. Rick Jeanneret and Rob Ray will have the call, with pregame coverage on MSG beginning at 6:30 p.m. The puck drops at 7.
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MB Electrician Pros is your local residential electrician serving Myrtle Beach and the surrounding areas in Horry County. Anytime you need an electrician in Myrtle Beach, you can place your trust in the excellent on-time service and expertise from MB Electrician Pros.
Many of our customers have relocated to the Myrtle Beach area from other parts of the country and they, along with local customers, have commented on the outstanding service they received, especially our on-time service excellence. Our residential customers with second homes in the area have full confidence we will fix any electrical issues whether they are in town or away.
Not only do local home owners trust MB Electrician Pros, local home builders and property management companies place their faith in our outstanding service. Whether it is a minor electrical repair, a room addition or a new home construction, local businesses in the home services niche rely on Mike Gurley and his team at MB Electrician Pros.
We have been selected as the Myrtle Beach electrician of choice for Myrtle Beach Home Services. This is a directory of local businesses serving home owners with their home maintenance needs. Only one business per category is selected for this local directory. We are proud to be the only electrician listed on the website.
You may be tempted to try and save a few dollars by trying to do electrical repairs yourself or by using a handyman. We even offer some tips in our regular blog posts for some small DIY jobs. However, when dealing with valuable equipment or your home and family, you will always want to rely on a professional and licensed electrician. Are you aware that some home owners' insurance policies do not cover damage done when a professional was not used?
What Does a Five Star Myrtle Beach Electrician have to offer?
Experienced Electricians – serving Horry County for over seven years, MB Electrician Pros is a fully insured and licensed electrician. Anytime you have an issue with the wiring in your home or some other electrical issue you can call us to quickly address the issue. Don't put your family's safety at risk when a professional quote is a phone call away.
Fast, Same-Day Service – With MB Electrician Pros you can be sure that your electrician will be on-time every time. We value your time and will always arrive at the time we specify. Plus, we are your emergency electrician when there is an immediate need.
Full Electrical Services – we provide full residential repairs and installation. We do not subcontract our services. Do you have an electrical issue that needs immediate attention? We are licensed electricians that can save you aggravation as well as time and money. We will get you back on track fast.
24/7 Emergency Services – MB Electrician Pros is able to respond to all electrical emergencies. We are here for you when you need us day or night.
Satisfaction Guaranteed – we provide a complete guarantee on all work done. And we will clean up your home when we are finished. Your satisfaction is our goal.
Before Electrical Service Quote – Not sure how much your electrical repair or improvement will cost? We provide up-front estimates so there are no surprises.
Save Money – we offer monthly special offers and discounts. Plus you will save money by having the job done right the first time. As a home owner you want to protect your most valuable investment – your home – and save money. Energy conservation is one way that MB Electrician Pros can not only save you money but help the environment at the same time. From simple changes in your lighting to installing energy-efficient appliances and electronic devises, we have the experience and knowledge to save you big.
System Maintenance – One of your top priorities as a Myrtle Beach home owner is keeping your electrical system maintained. This will prevent unnecessary emergencies and the inconvenience of unexpected repairs, including the loss of expensive electronic equipment and/or damage to your home. Installation of surge protection and regular check-ups can keep your family save and prevent unnecessary damage. Call us today for a home maintenance check-up.
Helpful and Friendly Service – You and your home will always be treated with respect. This blog provides helpful tips that will save you time and money on your home improvements.


Top 10 International Marketing Mistakes...!
1. "I have all kinds of products to offer."
All I need to hear is what my customer wants." A businessman interested in exporting auto parts to the Orient told me that he had the resources to furnish literally any automobile product that a customer wanted. I said, "That type of thinking won't work." He was taken aback, but persisted, "You don't get it. My company works with hundreds of suppliers. If your customer wants bearings, we can get it for you." I responded, "You don't get it. The customers aren't supposed to lead us. We're supposed to lead the customers!" This clearly came as a big surprise to him, and maybe to you, too -- but this is the kind of thinking that succeeds.
Focus and lead your customer like they have never been led before. Have them beg for your bundle of clear-cut product or service ideas. Take them to where they didn't even know they could go in terms of satisfaction, increased sales and profitability.
2. "My product price is really a very competitive."
Customers in Middle East and other South African countries pay attention to packaging first, quality next and price last. Set your priorities accordingly. Create a package design or service concept that speaks for itself, and quality that leaves no room for competitive comparison. From there, it's only a matter of details to wrap up a sale.
3. "That looks like a good foreign lead. Let's respond to it!"
I knew of a small company who occasionally received international inquiries. They determined the importance of the inquiries by the styling of their corporate letterhead. Four-color shiny graphics received the utmost attention. Plainly designed stationery was literally thrown out. You can imagine the professional consequences of this willingness to be impressed by snappy presentations at the expense of substance. Little did they know that most large, sophisticated and extremely busy companies typically communicate on whatever piece of paper they have at the moment and generally use no more than about ten words. Ostentation is out -- making things happen is in.
4. "Let's try exporting our product/service to a bunch of foreign markets."
Wrong! Pick a product/service and pick a market. Then stick to it. You need to put on your mental blinders and ignore distractions, channel your energies, and define the territory in which you're going to play. It takes a lot of discipline to resist the scattershot approach to doing business and stay focused, but after awhile the discipline becomes automatic. Focus, focus, focus. Persist, persist, persist.
5. "I'm really interested in exporting my products, but I'm not going to make any changes in it."
You must tailor your product to meet the needs of the customer. Forcing a customer to buy what you have available with little or no willingness on your part to make improvements is not just insensitive but downright hostile. Marketing has come a long way since the days of Henry Ford, who said, "The customer can have a car painted any color that he wants, so long as it is black."
6. "Let's respond to the customer's interest and then wait a couple of weeks to follow-up."
Put yourself in the customer's shoes. Would you want to be treated that way? The service brings satisfaction and satisfaction brings trial orders followed by repeat orders. Anything less than immediate and consistent service only waste your time -- and that of your prospective customer!
7. "I know my product/service works well here in the India, so I'm certain it will fly overseas."
Just because your product/service is needed here in the India does not by any means indicate that it will be well-received in a foreign country. You must always check with either your prospective customer (let them review it at no charge) or a local foreign consulate to see if they can help you determine if your service makes sense for their host country.
8. "I can't afford a trip to visit my customers. Besides, I wouldn't know my way around."
You can't afford not to meet with prospective customers because, without face-to-face contact, there will be no business. Of course, there is no need to travel overseas countries until you get associated with at least one importer/buyer in the respective country. Once you get associated with a customer, ask if you may visit them and if they would be so kind as to assist you on your first visit. You will be surprised at how gracious people really are, and how eagerly they welcome the opportunity to show you around their native land! Customers matter -- I can't repeat it often enough. The personal meeting is the best way to demonstrate your professional commitment.
9. "We appointed an exclusive agent, yet didn't get any sales."
When exporting a product, it is a smart practice to ask a distributor what they anticipate selling in the first year. Then, request that their first order be 20% of that anticipated volume, prepaid, which allows them the opportunity to have exclusivity. You should expect the balance of projected sales to be ordered during the rest of the year (preferably in quarterly periods), with each subsequent order minimally the size of their first one. This allows you to monitor and exercise good control over the distributor's sales.
10. "When our domestic sales slide, that's when we should work hard at getting foreign sales."
Going global is a commitment -- not something you work on one day and forget about the next. It's an investment in your company's future that deserves your consistent attention regardless of how well you're doing domestically. If you have patience and perseverance, then your chances of success will be excellent.
If you're open to changing the way you think about global marketing, you've already made a good beginning. Now you are ready to achieve success in export markets.


Corporate stakeholders, including both legislators and shareholders, are requesting that companies demonstrate that they have due diligence mechanisms in place to assess, and respond to, human rights concerns in their supply chains and operating areas.
Section 1502 of the new Dodd-Frank financial reform legislation requires companies using minerals originating in the Democratic Republic of Congo ("DRC"), or adjoining countries, to report on their "due diligence measures" regarding the source and chain of custody of those minerals. This provision, meant to address concerns that the purchase of "conflict minerals" is fueling conflict in the DRC, could impact companies in a wide range of industries depending on the final language of implementing regulations.
The new California Transparency in Supply Chains Act of 2010 asks retailers and manufacturers operating in California to disclose their efforts to "evaluate and address" the risks of human trafficking and slavery in their product supply chains.
Compliance with these requirements will not be straight-forward. It is frequently hard to identify consistently reliable sources of information regarding, for example, the source of specific minerals or the veracity of supplier assurances regarding the status of certain workers. What is clear is that these new requirements reflect a desire on the part of corporate stakeholders to ensure that corporate commitments to human rights go beyond short policy statements. Stakeholders increasingly expect companies to demonstrate that they have systems in place to assess, avoid, and mitigate the adverse impacts of their activities on human rights.
The legislative provisions and shareholder resolutions cited above are consistent with the recommendation put forward by the U.N. Special Representative for Business and Human Rights that companies carry out "human rights due diligence" in order to discharge their responsibility to respect human rights. As framed by the Special Representative (.pdf), human rights due diligence involves the implementation of policies, assessment mechanisms, and internal oversight and control systems to identify, prevent, and address the actual and potential adverse human rights impacts associated with a company's operations.
With the recent emergence of human rights due diligence as a mechanism to ensure accountability for the adverse human rights impacts associated with corporate activity, companies, and their counsel, should evaluate the extent to which they have developed policies and oversight mechanisms sufficient to address stakeholder concerns and expectations.


Yesterday I went to my first Red Sox game of the season, with my friend Dan.
It was a blast: a beautiful ~70-degree Saturday afternoon at Fenway Park, the Red Sox beating a disliked division opponent (Tampa Bay), and lots of good conversation.
Former HubSpot employee and current Red Sox DJ TJ (not a typo, a DJ named TJ) saw our tweet from the game, and played a courtesy song for us on the loudspeaker, which was awesome.
Great start to the season. Both Dan and I will be there (separately with other friends, but I'm sure we'll meet up to say hi) in the big Red Sox – Yankees 100th Anniversary game coming up Friday afternoon.


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Ben Honcoop poses for a photo with one of the Ben's Towing trucks. (File photo)
Shuswap tow truck operator sees high number of collisions this summer
Drivers encouraged to "loosen up behind the wheel, smarten up and read the road"
Aug. 17, 2019 6:00 a.m.
Increased traffic, impatient drivers and outdated infrastructure.
These are some of the things to which Ben Honcoop, owner of Ben's Towing, attributes the volume of collisions he's seen on Shuswap highways this summer.
"This has probably been one of our busiest years…, you bet," said Honcoop, who has been in the towing business for more than 46 years.
"There's so much traffic out there these days. I think the biggest problem is the volume of traffic, and people not paying attention to their driving habits."
The problem of traffic volume, Honcoop explains, is exacerbated by inadequately sized sections of the Trans-Canada Highway.
"The four laning in this area here is probably 10 years overdue," said Honcoop, adding the Salmon Arm West project currently underway, which will include the replacement of the Salmon River Bridge, will help only so far as the four-laning is extended. "When that little four-lane piece stops in front of us here, until it carries on to the next project, you're just moving the bottle neck from one point to another."
What are most concerning spots in the Shuswap for collisions? For Honcoop, the Highway 1/Balmoral Road intersection is one that stands out.
"That intersection, how shall we put this – was a very dumb move on the part of the Highways," said Honcoop. "They decided just to go with the intersection they have now rather than go with an overpass-type of intersection. Apparently it was budget related, but if you figure how many people have been injured and killed in that intersection, you could probably have built four cloverleafs.
"Also, the speed at that four-lane crossing, 100 kilometres an hour, is too fast. People just don't have enough time to try and dart across four lanes of traffic when you're either trying to go to town or come back."
Other troublesome spots include the Highway 1/Highway 97B intersection, where Honcoop suggests the speed limit should be lowered from 90 to 80 km/h, and the Highway 1/30th Street SW intersection that leads to SmartCentres and Walmart.
"We do a ton of accidents there…," said Honcoop. "People going into Walmart from the west, coming into town, we see a lot of them there. More so than going the other way."
Read more: Plan chosen for safety upgrades at Balmoral intersection
Read more: Alcohol suspected behind head-on collision on Highway 1 in Salmon Arm
Read more: New highway markings in North Okanagan expected to slow speeders
Read more: UPDATE: Trans-Canada Highway reopens after fatal collision west of Salmon Arm
Being the Shuswap, weather is also a contributing factor behind collisions. Honcoop notes how even a subtle change in elevation and temperature during winter can make driving treacherous. He's seen this west of town on Highway 1 near Shuswap Lake Estates and, to the east, between Salmon Arm and Sicamous.
"You gain the altitude right at the Canoe sawmill… In the winter, there's just that much altitude difference and not as much sunlight, and you'll get to the top of those S-turns and it will be snowing – while at the Canoe sawmill it could be raining."
One positive Honcoop is seeing in collisions of recent years is that more people are surviving them. This he attributes to the design of modern vehicles.
"New cars crumple up way faster, but they absorb impact more, which leaves less impact on the human body…," said Honcoop. "Those are advances in technology and you know what, if our cars were built today as they were in the 1950s and '60s, every second crash everybody would be dead."
Honcoop has seen a number of other positive changes, including the creation of dedicated highway rescue crews ("I can remember 30 years ago when we used to do all that stuff and there was no jaws of life. There was the tow truck and the ambulance people."), and the addition of concrete barriers on meridians, such as on Highway 97 south of Vernon near the turnoff to Predator Ridge ("fatalities and accidents have gone way down since they put the big divider down the middle there").
What needs to change now, says Honcoop, are drivers. They need to "loosen up behind the wheel, smarten up and read the road." And if the province or anyone making decisions regarding local highway safety improvements is in need of input, Honcoop is available.
"Maybe they should come down to the people that are right on the street, doing it every day, and say, 'hey, what do you think we should do?' That might be advantageous in future planning," said Honcoop.
@SalmonArm
newsroom@saobserver.net
North Okanagan-Shuswap Liberal candidate responds to Trudeau ethics report
Man that named Revelstoke Dam as potential terrorist target may be released

redpajama_set_name: RedPajamaCommonCrawl


As the most pervasive skin condition in the U.S., some 50 million Americans struggle with acne. Interestingly, while everyone's skin is fundamentally the same, the skin's reaction to hormonal fluctuations, oils and bacteria is not. As noted in an article by Marie Claire, even those that adhere to a prescription skin care regimen and avoid dairy, soy and sugar are not immune to getting zits. Given the constant flux of seemingly perfect people in advertisements, magazines and television, it's clear that acne affects more than the skin, as it takes a toll on one's emotional health.
Furthermore, while one might be tempted to pop the occasional pimple, the American Academy of Dermatology warns that do-it-yourself pimple popping can backfire.
Why shouldn't you pop a pimple and when is it okay to pop a pimple?
When is it okay to pop a pimple?
What do you do after popping a pimple? What should you apply to help heal the pimple?
What should you apply to avoid acne scarring?
For the most part, individuals shouldn't pop a pimple themselves. Doing so puts them at risk for more inflammation and hyperpigmentation, not to mention it often leads to a bigger pimple than before. What's more, there's the chance of infection, which is due to a portion of the capsule getting trapped. Without question, this can make acne more noticeable, painful and can prolong the lifespan of the pimple.
On the other hand, if a person has a hot date, he or she might take a chance and pop his own pimple. In this case, it's helpful to expose the skin to warm steam from a shower first. Next, cleanse the area with rubbing alcohol, and use two clean Q-tips to firmly press around the area of the pimple for complete extraction of the capsule. Finally, spot treat the area using a Q-tip with glycolic/salicylic acid serum. If a person has darker skin, use SPF to guard against post inflammatory hyperpigmentation.
If forced to pop one's own pimple, it's important to know how to prevent acne scarring. Perhaps the best way is to visit a dermatologist or Nurse Practitioner specializing in dermatology and/or aesthetic medicine. In fact, addressing acne should be done preemptively and proactively to lessen the chance of developing scars. Acne scars occur from either picking or an overproduction of sebum in which P. acnes bacteria causes infection and inflammation in the form of a painful cyst beneath the skin. Upon visiting a doctor, a patient might be injected with a temporary solution such as Triamcinolone or "cortisone," though more physicians are using off-label 5-Fluorouracil due to its lower risk profile.
Ultimately, to prevent permanent acne scars, the best option is to address the source of the problem. Conventional treatments have involved antibiotics, hormone antagonists and topical agents. Accutane, which is considered the gold standard in the treatment of cystic acne, has successfully treated teens and adults of all ages.
Meanwhile, there are non-pharmaceutical alternatives that target cystic acne. One such solution is photodynamic therapy treatment paired with a stringent topical acne program using colloidal silver antimicrobial spray, high potency tretinoin, glycolic and salicylic acid. During treatment, individuals forego using any products with oil. Once oil production is better managed, patients undergo a dual approach of subcission and undermining of scar tissue, as well as skin resurfacing with the CO2 laser or clear and brilliant. Finally, TCA blue peels minimize global acne scarring with more aggressive resurfacing.
Through a unique combination of treatment modalities, Dr. Ben Talei at The Beverly Hills Center for Plastic & Laser Surgery utilizes medical, laser (non-invasive) and surgical treatments to provide the most advanced outcomes for those suffering from acne. As a dual board certified facial plastic surgeon, Dr. Talei is well-known for helping patients achieve natural, long-lasting results and impeccable facial aesthetics. In turn, he understands the social pressures and stress that skin irregularities can cause. Thus, Dr. Talei and his staff are attentive to the unique needs of patients, as they work alongside dermatology colleagues to ensure effective treatment for acne with superior results.
Providing leading edge acne treatments designed for your unique skin, the Beverly Hills Center for Plastic & Laser Surgery welcomes your call today.


text:
Register your study
Update your record
Report your results
Result of results found for within
Previous Trial Back to results Next Trial
ISRCTN56969091 https://doi.org/10.1186/ISRCTN56969091
Efficacy, safety and tolerability of PSD502 in subjects with premature ejaculation (PE)
Condition category
Mental and Behavioural Disorders
Date applied
Prospective/Retrospective
Retrospectively registered
Overall trial status
No longer recruiting
Results overdue
Plain English Summary
Not provided at time of registration
Trial website
Dr Bogdan Stelmach
Prowent Stelmach Bogdan
ul.Stoczkowska 13
prowent@interia.pl
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
PSD502-PE-005
Scientific title
A phase II multicentre double-blind randomised placebo-controlled four-way cross-over dose-range funding study to evaluate efficacy, safety and tolerability of PSD502 in subjects with premature ejaculation (PE)
Study hypothesis
PSD502 spray consists of lidocaine, prilocaine and norflurane (HFA-134a), which acts as a propellant and solvent. Upon application HFA-134a evaporates from the site (glans penis), leaving a liquid deposit of pure lidocaine and prilocaine. Any excess is wiped off the glans penis. Three sprays are applied to each third of the glans penis to ensure that the whole glans penis is covered with study medication.
The two clinical studies ANAE-059-00 and PSD502-PE-001 show that three sprays of PSD502 applied evenly to the surface of the glans penis result in a desirable prolongation of intravaginal ejaculation latency time (IELT) (efficacious effect), with an acceptably small degree of numbness of the glans penis (pharmacological adverse effect). There is some variability in the actual dose remaining on the glans penis due to the process of spraying a small area (hence not all drug lands on the glans) and wiping off excess drug, so the received dose for each individual is inevitably not precise (in study PSD502-PE-003, the highest received dose was approximately nine-fold greater than lowest received dose after applying as recommended, i.e., glans wiped 5 minutes after application). Despite this variability, numbness in this study did not appear to be directly related to actual received dose.
The aim of this study is to confirm that a higher or lower concentration of PSD502 would not show an improved therapeutic window, that is, significantly improved efficacy and/or reduced numbness or other adverse effects.
The doses chosen for this study were intended to include the clinical dose used in the efficacy studies in the PE programme, plus a dose below and a dose above, with a reasonable dose interval, in order to achieve a dose response curve to help confirm the clinical dose for PE. In view of the variability of drug present on the target organ (glans penis) after spraying with PSD502 (see above), it was considered that a 10-fold dose difference would be optimal to ensure three truly different doses were tested. This was achieved with the lower dose and the middle dose. However, due to technical reasons, it was not possible to achieve a concentration which was 10-fold higher than the middle dose. The highest dose which could be achieved was a little under two-fold higher than the middle dose. The middle dose had been used in the clinical trials to date, so it was important that this dose was included in the trials. Consequently, the top dose was chosen to be the highest dose achievable.
As of 28/01/2010 this record has been updated to include the actual target number of participants; the initial target number of participants was 'approximately 40 randomised subjects to ensure 24 subjects complete the study'.
1. Czech Republic: State Institute for Drug Control SUKL approved on the 29th December 2008 (ref: Sukls127711/2008)
2. Poland: The office for registration of medicinal products, medical devices and biocidal products approved on the 24th April 2009 (ref: 139/UR/CEBK/04/09)
Multicentre double-blind randomised placebo-controlled four-way cross-over study
Primary study design
Secondary study design
Randomised controlled trial
Trial setting
The subject and their sexual partner will attend a Screening Visit (Visit 1) at which both will provide written informed consent and will be screened for eligibility. Screening for the subject will involve collection of demographic information, medical history (including history of PE), medication history, physical examination including examination of the glans penis, heart rate (HR), blood pressure (BP), 12-lead electrocardiogram (ECG) and haematology and biochemistry testing. The subject will also be asked to complete questions to enable classification according to the International Index of Erectile Function (IIEF-5).
Subjects that pass the initial screening assessments will then undergo a Baseline Evaluation period of 2 weeks during which they are required to have at least one sexual encounter using the stopwatch with a recorded IELT less than or equal to 1 minute as documented in the diary card. Upon completion of the Baseline Evaluation period, subjects will return to the centre for Visit 2. Adverse event (AE) and concomitant medication information will be collected and the glans penis will be examined.
Eligible subjects will be randomised to the 4 week double-blind treatment phase and dispensed drug (3 mg, 30 mg, 53 mg or placebo) for the first treatment period. The subject will be instructed on how to use the spray and instructed to leave at least 24 hours between each sexual encounter using the spray. During each sexual encounter where the study medication is used, the subject or his sexual partner will time the IELT using a stopwatch. The subject will document efficacy and tolerability and the partner will document tolerability data in respective diary cards.
During the 4 week double-blind treatment phase subjects will return to the centre at weekly intervals between treatment periods (Visits 3, 4, and 5) and receive a new dose of study medication. Subjects are to have at least one sexual encounter using the spray per treatment period and have at least 24 hours between sexual encounters using the spray. At Visits 3, 4 and 5 the diary card and the previously dispensed medication will be checked, collected and new medication and diary card for the next treatment period will be provided to the subject.
At the end of the double-blind treatment phase, the subject will return to the centre for Visit 6. At this final follow up visit he will undergo physical examination including examination of the glans penis, heart rate (HR), blood pressure (BP) measurement, 12-lead electrocardiogram (ECG), haematology and biochemistry testing. The diary card and the medication dispensed on Visit 5 will be checked and collected. AE and Concomitant Medication enquiries will be made at Visits 2 - 6. AEs for the partner will also be collected throughout the study.
The total duration of the trial is 6 weeks from the point of consent.
Drug names
PSD502
Primary outcome measure
Changes in mean IELT from baseline to during each of the 4 treatment periods, which are 7 days +/-4 days in length, and the baseline period, which is 2 weeks +/-4 days in length.
Secondary outcome measures
Evaluation of the safety and tolerability of PSD502 compared with placebo in subjects with PE as measured by adverse event (AE) and serious adverse event (SAE) data for both the subject and his sexual partner, collected throughout the study.
Overall trial start date
Overall trial end date
Reason abandoned (if study stopped)
Participant inclusion criteria
1. Has provided written informed consent
2. Male and aged 18 years and over
3. Diagnosed with lifelong premature ejaculation (PE) according to International Society of Sexual Medicine (ISSM) criteria, that is, he ejaculates always or nearly always prior to or within about one minute of vaginal penetration; and is unable to delay ejaculation on all or nearly all vaginal penetrations; and experiences negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy
4. Subject must be in a stable heterosexual and monogamous relationship of at least 3 months duration with his partner
5. Subject has at least documented one sexual encounter in the baseline period
6. IELT less than or equal to 1 minute in at least one sexual encounter in the baseline period
7. Willing and able to comply with the study procedures
8. The subject's sexual partner must provide written informed consent, be aged 18 years or over and willing to comply with the study procedures
Target number of participants
35 randomised to this trial
Participant exclusion criteria
1. Subject, or his sexual partner, has received an investigational (non-registered) drug within 30 days of screening
2. Subject has erectile dysfunction, defined as an International Index of Erectile Function-5 (IIEF-5) score of less than or equal to 21, unless the low score is entirely related to PE symptoms in the opinion of the Investigator
3. Subject, or his sexual partner, has any physical or psychological condition that would prevent them from undertaking the study procedures, including, but not limited to, the following:
3.1. Urological disease (e.g. prostatitis, urinary tract infection) or genito-urinary surgery within 8 weeks of screening
3.2. Ongoing significant psychiatric disorder (e.g., bipolar disease, depression/anxiety disorder or schizophrenia) not controlled by medication
4. Subject has safety testing abnormalities at the screening visit, in particular liver function tests, that are indicative of a medical condition that would preclude further participation in the opinion of the Investigator
5. Subjects taking tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs) or selective serotonin reuptake inhibitors (SSRIs), for indications other than PE, where the dose has been changed within 4 weeks of screening and it is planned that the dose will change during the double-blind treatment period
6. Subject has previously received treatment with PSD502 for PE
7. Subject has received any treatment for PE, e.g. anti-depressant therapy, local anaesthetic spray, intra-cavernosal injection or psychotherapy within 4 weeks of screening
8. Subject, or his sexual partner, has a current history of alcohol or drug abuse, in the opinion of the Investigator
9. Subject, or his sexual partner, has known drug sensitivity to amide-type local anaesthetics
10. Subjects with pregnant partners or those not using adequate forms of contraception. These include vasectomy, female hormonal contraception, intra-uterine device (IUD) or cap plus spermicide. The use of condoms is not permitted throughout the baseline and treatment period.
11. Subject, or his sexual partner, has a history of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency or use of medications that would increase susceptibility to methemoglobinemia (e.g. anti-malarial agents)
12. Subject, or his sexual partner, uses class I (e.g. mexiletine, tocainide) or III (e.g. amiodarone, sotalol) anti-arrhythmic drugs
Recruitment start date
Recruitment end date
Countries of recruitment
Czech Republic, Poland
Trial participating centre
Warsaw,
Plethora Solutions Ltd (UK)
Sponsor details
WC1V 7DN
mail@plethorasolutions.co.uk
http://www.plethorasolutions.co.uk/index.php
Funder name
Alternative name(s)
Funding Body Type
Funding Body Subtype
Sciele Pharma Ltd (USA)
Results and Publications
Publication and dissemination plan
Intention to publish date
Participant level data
Basic results (scientific)
Publication citations
21/11/2019: No publications found. Verifying results with principal investigator.
Publish with BioMed Central
المعلومات ب اللغة العربية
信息简体中文


text:
United Kingdom Legislation page 139
You are here: BAILII >> Browse A-Z title lists >> United Kingdom Legislation page 139
URL: https://www.bailii.org/indices/uk-legis-0139.html
The Highland Acute Hospitals National Health Service Trust (Establishment) Order 1998 No. 2722 (S. 149)
The Highland Communities National Health Service Trust (Establishment) Amendment Order 1999 No. 366 (S. 20)
The Highland Communities National Health Service Trust (Establishment) Order 1993 No. 3026 (S. 284)
The Highland (Electoral Arrangements) Order 1998 No. 3248 (S. 204)
The Highland Primary Care National Health Service Trust (Establishment) Amendment Order 1999 No. 1069 (S. 80)
The Highland Primary Care National Health Service Trust (Establishment) Order 1998 No. 2721 (S. 148)
The Highland Region (Electoral Arrangements) Order 1993 No. 1094 (S. 151)
The Highland Regional Council (Abhainn Greadhain, Glenachulish) Water Order 1987 No. 1390 (S. 106)
The Highland Regional Council (Abhainn Mhungasdail) Water Order 1992 No. 998 (S. 96)
The Highland Regional Council (Abhainn Shlatach) Water Order 1988 No. 20 (S. 4)
The Highland Regional Council (Allt Bail'an Tuim Bhuidhe) Water Order 1989 No. 1923 (S. 136)
The Highland Regional Council (Allt Sanna, West Ardnamurchan) Water Order 1987 No. 1392 (S. 108)
The Highland Regional Council (Forest Spring, Storr, Skye) Water Order 1987 No. 1391 (S. 107)
The Highland Regional Council (Kilfinnan Burn) Water Order 1992 No. 30 (S. 2)
The Highland Regional Council (Loch a'Choire Leith) Water Order 1987 No. 1879 (S. 130)
The Highland Regional Council (Loch an t-Seana Bhaile) (Amendment) Water Order 1988 No. 21 (S. 5)
The Highland Regional Council (Loch Beannach) Water Order 1989 No. 204 (S. 21)
The Highland Regional Council (Loch Lannsaidh) Water Order 1990 No. 715 (S. 88)
The Highland Regional Council (River Einig, Oykel Bridge) Water Order 1990 No. 1165 (S. 134)
The Highland Regional Council (River Lael and Allt Gleann a' Mhadaidh) Water Order 1989 No. 117 (S. 14)
The Highland River Purification Board (Establishment) Variation Order 1992 No. 1164 (S. 111)
The Highlands and Islands Agricultural Programme Amendment Regulations 1999 No. 647 (S. 40)
The Highlands and Islands Agricultural Programme Regulations 1994 No. 3096 (S. 167)
The Highlands and Islands Development Board Dissolution Order 1992 No. 1764 (S. 169)
The Highlands and Islands Rural Enterprise Programme (Amendment) Regulations 1992 No. 772 (S. 80)
The Highlands and Islands Rural Enterprise Programme Regulations 1991 No. 780 (S. 73)
The Highlands and Islands Rural Enterprise Programme (Revocation) Regulations 1993 No. 2325 (S. 243)
The Highlands of Scotland Tourist Board Scheme Amendment Order 1995 No. 2236 (S. 164)
The Highlands of Scotland Tourist Board Scheme Order 1995 No. 1886 (S. 133)
The Highway and Railway (Nationally Significant Infrastructure Project) Order 2013 No. 1883
The Highway Litter Clearance and Cleaning (Transfer of Duties) Order 1991 No. 337
The Highway Litter Clearance and Cleaning (Transfer Of Responsibility) (A13 Trunk Road) Order 2000 No. 1508
The Highway Litter Clearance and Cleaning (Transfer of Responsibility) (England) (Amendment) Order 2010 No. 2401
The Highway Litter Clearance and Cleaning (Transfer of Responsibility) (England) Order 2009 No. 2677
The Highway Litter Clearance and Cleaning (Transfer Of Responsibility) (North West Leicestershire and South Derbyshire) Order 1999 No. 1007
The Highway Litter Clearance and Cleaning (Transfer of Responsibility) Order 1997 No. 2960
The Highway Litter Clearance and Cleaning (Transfer of Responsibility) Order 1998 No. 467
The Highways Act 1980 (Gating Orders) (England) Regulations 2006 No. 537
The Highways (Assessment of Environmental Effects) Regulations 1988 No. 1241
The Highways (Assessment of Environmental Effects) Regulations 1999 No. 369
The Highways, Crime Prevention etc.(Special Extinguishment and Special Diversion Orders) Regulations 2003 No. 1479
The Highways England Company Limited (M6 Junction 10) (Slip Roads, Special Roads) Scheme 2018 Confirmation Instrument 2019
The Highways England Company Limited M11 Harlow North Junction (7A) (Slip Roads, Special Roads) Scheme 2018 Confirmation Instrument 2019
The Highways England Company Limited (M49 Avonmouth Junction) (Slip Roads, Special Roads) Scheme 2017 Confirmation Instrument 2017 No. 1120
The Highways (Environmental Impact Assessment) Regulations 2007 No. 1062
The Highways (Inquiries Procedure) Rules 1994 No. 3263
The Highways Noise Payments and Movable Homes (England) (Amendment) Regulations 2000 No. 3086
The Highways Noise Payments and Movable Homes (England) (Amendment) Regulations 2001:
The Highways Noise Payments and Movable Homes (England) Regulations 2000 No. 2887
The Highways (Road Humps) (Amendment) Regulations 1990 No. 1500
The Highways (Road Humps) (Local Inquiries) Regulations 1986 No. 1858
The Highways (Road Humps) Regulations 1990 No. 703
The Highways (Road Humps) Regulations 1996 No. 1483
The Highways (SSSI Diversion Orders) (England) Regulations 2007 No. 1494
The Highways (Traffic Calming) (Amendment) Regulations 2000 No. 1511
The Highways (Traffic Calming) Regulations 1993 No. 1849
The Hijacking Act 1971 (Guernsey) Order 1971 No. 1744
The Hijacking Act 1971 (Overseas Territories) (Amendment) Order 1973 No. 1893
The Hijacking Act 1971 (Overseas Territories) Order 1971 No. 1739
The Hill Farm Allowance (Amendment) Regulations 2006 No. 518
The Hill Farm Allowance Regulations 2001 No. 476
The Hill Farm Allowance Regulations 2002
The Hill Farm Allowance Regulations 2008 No. 51
The Hill Farming Improvements Order 1949 No. 548
The Hill Farming Improvements (Piers, etc.) Order 1949 No. 2169
The Hill Farming Improvements (Settled Land and Trusts for Sale) Regulations 1951 No. 1816
The Hill Livestock (Compensatory Allowances) (Amendment) (No. 2) Regulations 1993 No. 2924
The Hill Livestock (Compensatory Allowances) (Amendment) (No.2) Regulations 1991 No. 1439
The Hill Livestock (Compensatory Allowances) (Amendment) Regulations 1987 No. 2129
The Hill Livestock (Compensatory Allowances) (Amendment) Regulations 1990 No. 308
The Hill Livestock (Compensatory Allowances) (Amendment) Regulations 1993 No. 70
The Hill Livestock (Compensatory Allowances) (Enforcement) Regulations 1999 No. 3315
The Hill Livestock (Compensatory Allowances) Regulations 1992 No. 269
The Hill Livestock (Compensatory Allowances) Regulations 1993 No. 2631
The Hillingdon Community Health National Health Service Trust Dissolution Order 1994 No. 863
The Hillingdon Community Health National Health Service Trust (Establishment) Order 1991 No. 2359
The Hillingdon Health Authority (Transfer of Trust Property) Order 2002
The Hillingdon Hospital National Health Service Trust (Establishment) Amendment Order 1999 No. 1769
The Hillingdon Hospital National Health Service Trust (Establishment) Order 1990 No. 2418
The Hillingdon Hospital National Health Service Trust (Transfer of Trust Property) Order 1994 No. 623
The Hillingdon Hospital National Health Service Trust (Transfer of Trust Property) Order 2009 No. 1928
The Hillingdon Primary Care Trust (Establishment) Amendment Order 2001
The Hillingdon Primary Care Trust (Establishment) Order 2000 No. 209
The Hinchingbrooke Health Care National Health Service Trust Dissolution Order 1993 No. 822
The Hinchingbrooke Health Care National Health Service Trust (Establishment) Order 1991 No. 2360
The Hinchingbrooke Health Care National Health Service Trust (Establishment) Order 1993 No. 823
The Hinchingbrooke Health Care National Health Service Trust (Transfer of Trust Property) Order 1994 No. 2691
The Hinckley and Bosworth Primary Care Trust (Establishment) Order 2001
The Hinckley College (Dissolution) Order 1996 No. 249
The Hinkley Point C (Nuclear Generating Station) (Amendment) Order 2015 No. 1666
The Hinkley Point C (Nuclear Generating Station) (Amendment) Order 2017 No. 843
The Hinkley Point C (Nuclear Generating Station) (Correction) Order 2013 No. 2938
The Hinkley Point C (Nuclear Generating Station) Order 2013 No. 648
The Hinkley Point Harbour Empowerment Order 2012 No. 1914
The Hinkley Point (Temporary Jetty) (Land Acquisition) Order 2012 No. 1924
The Hirwaun Generating Station (Amendment) Order 2016 No. 1087
The Hirwaun Generating Station (Correction) Order 2015 No. 2070
The Hirwaun Generating Station Order 2015 No. 1574
The HIV Testing Kits and Services Regulations 1992 No. 460
The HIV Testing Kits and Services (Revocation) (England) Regulations 2014 No. 451
The HMSO Trading Fund (Amendment) Order 1994 No. 1192
The HMSO Trading Fund (Revocation) Order 1996 No. 2483
The Holders of Hereditary Peerages (Extension of the Franchise) (Transitional Provisions) Order 1999 No. 3322
The Holders of Hereditary Peerages (Overseas Electors) (Transitional Provisions) Order 2001 No. 84
The Holme Lacy College (Dissolution) Order 1999 No. 1997
The Holy Family Roman Catholic and Church of England College (Designation as having a Religious Character) Order 2007 No. 1983
The Holy Rood Catholic Primary School (Designation as having a Religious Character) Order 2007 No. 3551
The Holy Trinity Catholic Primary School (Designation as having a Religious Character) Order 2005 No. 1231
The Holy Trinity CE VC Primary School & Nursery Unit (Designation as having a Religious Character) Order 2007 No. 3557
The Holy Trinity Rosehill (VA) CE Primary School (Designation as having a Religious Character) Order 2006 No. 1898
The Home Energy Conservation Act 1995 (Commencement No. 2) (England) Order 1995 No. 3340 (C. 79)
The Home Energy Conservation Act 1995 (Commencement No. 3) (Scotland) Order 1996 No. 2797 (C. 82)
The Home Energy Conservation Act 1995 (Commencement No. 4) (Wales) Order 1996 No. 3181 (C. 100)
The Home Energy Efficiency Grants (Amendment) Regulations 1993 No. 2799
The Home Energy Efficiency Grants (Amendment) Regulations 1994 No. 637
The Home Energy Efficiency Grants (Amendment) Regulations 1995 No. 49
The Home Energy Efficiency Grants Regulations 1990 No. 1791
The Home Energy Efficiency Grants Regulations 1992 No. 483
The Home Energy Efficiency Scheme (Amendment) (Scotland) Regulations 1999 No. 1018 (S. 72)
The Home Energy Efficiency Scheme (England) (Amendment) (No. 2) Regulations 2003
The Home Energy Efficiency Scheme (England) (Amendment) Regulations 2002
The Home Energy Efficiency Scheme (England) (Amendment) Regulations 2003 No. 1017
The Home Energy Efficiency Scheme (England) (Amendment) Regulations 2011 No. 833
The Home Energy Efficiency Scheme (England) Regulations 2000 No. 1280
The Home Energy Efficiency Scheme Regulations 1997 No. 790
The Home Guard (Amendment) Order 1989 No. 1335
The Home Guard (Amendment) Order 1993 No. 597
The Home Information Pack (Amendment) (No.3) Regulations 2008 No. 3107
The Home Information Pack (Amendment) Regulations 2008 No. 572
The Home Information Pack (No. 2) Regulations 2007 No. 1667
The Home Information Pack (Redress Scheme) (No.2) Order 2007 No. 1946
The Home Information Pack (Redress Scheme) Order 2007 No. 560
The Home Information Pack (Redress Scheme) (Revocation) Order 2007 No. 1536
The Home Information Pack Regulations 2007 No. 992
The Home Information Pack (Revocation) Regulations 2007 No. 1525
The Home Information Pack (Suspension) Order 2010 No. 1455
The Home Loss Payment (Specification of Amount) (Scotland) Regulations 1989 No. 47 (S. 2)
The Home Loss Payments (England) Regulations 2003 No. 1706
The Home Loss Payments Order 1989 No. 24
The Home Loss Payments (Prescribed Amounts) (England) Regulations 2006 No. 1658
The Home Loss Payments (Prescribed Amounts) (England) Regulations 2016 No. 789
The Home Loss Payments (Prescribed Amounts)(England) Regulations 2004 No. 1631
The Home Purchase Assistance (Commutation of Repayments) Order 1994 No. 548
The Home Purchase Assistance (Price-limits) Order 1987 No. 268
The Home Purchase Assistance (Recognised Lending Institutions) (No. 1) Order 1988 No. 84
The Home Purchase Assistance (Recognised Lending Institutions) (No. 2) Order 1987 No. 1809
The Home Purchase Assistance (Recognised Lending Institutions) Order 1987 No. 1202
The Home Purchase Assistance (Recognised Lending Institutions) Order 1989 No. 956
The Home Purchase Assistance (Winding Up of Scheme) Order 1990 No. 374
The Home Repair Assistance (Extension) (England) Regulations 1999 No. 2766
The Home Repair Assistance (Extension) Regulations 1998 No. 2998
The Home Repair Assistance Regulations 1996 No. 2887
The Home-Grown Cereals Authority Levy Scheme (Approval) Order 1987 No. 671
The Home-Grown Cereals Authority Levy (Variation) Scheme (Approval) Order 1990 No. 1316
The Home-Grown Cereals Authority Levy (Variation) Scheme (Approval) Order 2001
The Home-Grown Cereals Authority Oilseeds Levy Scheme (Approval) Order 1990 No. 1317
The Home-Grown Cereals Authority (Rate of Levy) Order 1987 No. 1194
The Home-Grown Cereals Authority (Rate of Levy)Order 2001
The Homeless Persons (Priority Need) (Scotland) Order 1997 No. 3049 (S. 193)
The Homelessness Act 2002 (Commencement No. 1) (England) Order 2002
The Homelessness Act 2002 (Commencement No. 2 and Transitional Provisions) (England) Order 2002
The Homelessness (Asylum-Seekers) (Interim Period) (England) Order 1999 No. 3126
The Homelessness (Decisions on Referrals) Order 1998 No. 1578
The Homelessness (Decisions on Referrals) (Scotland) Order 1998 No. 1603 (S. 88)
The Homelessness (England) Regulations 2000 No. 701
The Homelessness (Isles of Scilly) Order 1997 No. 797
The Homelessness (Persons subject to Immigration Control) (Amendment) Order 1997 No. 628
The Homelessness (Priority Need for Accommodation) (England) Order 2002
The Homelessness Regulations 1996 No. 2754
The Homelessness (Review Procedure etc.) Regulations 2018 No. 223
The Homelessness (Suitability of Accommodation) (Amendment) Order 1997 No. 1741
The Homelessness (Suitability of Accommodation) (England) Order 2003
The Homelessness (Suitability of Accommodation) (England) Order 2012 No. 2601
The Homelessness (Suitability of Accommodation) Order 1996 No. 3204
The Homerton Hospital National Health Service Trust (Change of Name) Order 2001
The Homerton Hospital National Health Service Trust (Establishment) Amendment Order 1998 No. 3192
The Homerton Hospital National Health Service Trust(Establishment) Order 1994 No. 3181
The Homes and Communities Agency (Transfer of Property etc.) (No. 2) Regulations 2016 No. 515
The Homes and Communities Agency (Transfer of Property etc.) Regulations 2015 No. 1471
The Homes and Communities Agency (Transfer of Property etc) Regulations 2017 No. 199
The Homes and Communities Agency (Transfer of Property etc.) Regulations 2018 No. 8
The Homes and Communities Agency (Transfer of Property etc.) Regulations 2019
The Homes Insulation Grants Order 1987 No. 2185


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Top 10 Safest Destinations for Women Traveling Solo
Traveling solo doesn't have to be scary or intimidating if you're a woman. There are many safe locations for women to visit without having to worry about venturing alone. In this guide, we're looking at the ten safest destinations for women traveling solo.
Women traveling solo will love the laid-back vibe they find in Amsterdam. Discover the city's unique culture and nightlife as you explore the canals. Meet locals when you rent a bike to travel around and experience the cafe and food culture.
When you're looking for diverse landscapes and wildlife, Australia is one of the world's best destinations for experiencing that. Some women choose this destination for their first solo trip. Hike through Kata Tjuta, ride the Ghan Train, and explore the Outback.
Some of the most breathtaking landscapes are in Canada. No matter where you go in Canada, you'll experience multiculturalism. With its reputation for being one of the friendliest countries, Canada is an excellent destination for women traveling solo.
Even though this isn't a specific destination, women traveling solo will love going on a cruise. Not only is it a safe option, but it's a great way of journeying through many parts of the world. The convenience of itinerary and secure accommodations is both benefits to women traveling solo.
Traveling solo to French Polynesia means you'll have opportunities to experience some of the world's best diving. The diverse marine life and natural beauty of the landscape create unforgettable memories. Some women love traveling solo to this destination so much; they make it an annual excursion.
This location is not only beautiful, but it's also comfortable for women traveling solo. You'll find a bustling nightlife in Reykjavik where mingling with other travelers and locals is a fun adventure. There are also many opportunities for touring and snorkeling.
The Emerald Isle is lush and full of green landscapes because of its weather. While some may not like wet weather, others flourish in Ireland's countryside. If you love beer, you'll also find an assortment of local pubs to visit.
If you're a woman traveling solo, hitting the stunning deserts of Africa's Namibia is worth adding to your list of destinations. Year-round road trips in Namibia and exploring the Skeleton Coast are just a couple of ways you can enjoy this area.
Traveling solo to this destination means you're in for a lot of adventure. From the fjords to the beaches to the glaciers, there's no shortage of opportunities for women traveling solo. Some of the most beautiful landscapes women traveling solo will see in the world are in New Zealand.
Experience meadows of wildflowers, gorgeous mountain scenery, and the Rhone river creating an unforgettable backdrop. Check out Geneva for access to the jet d'leau, lakeshore, Parc de la Grange, and many other incredible locations.
Women who are traveling solo don't have to worry about their safety when visiting these ten locations. There are opportunities for exploring, adventures, and new experiences. Contact your travel agent today to book your solo trip!
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MIA > Archive > Connolly
Labour and the Proposed Partition of Ireland
From Irish Worker, 14 March 1914.
Transcribed by The James Connolly Society in 1997.
The recent proposals of Messrs. Asquith, Devlin, Redmond and Co. for the settlement of the Home Rule question deserve the earnest attention of the working class democracy of this country. They reveal in a most striking and unmistakeable manner the depths of betrayal to which the so-called Nationalist politicians are willing to sink. For generations the conscience of the civilised world has been shocked by the historical record of the partition of Poland; publicists, poets, humanitarians, patriots, all lovers of their kind and of progress have wept over the unhappy lot of a country torn asunder by the brute force of their alien oppressors, its unity ruthlessly destroyed and its traditions trampled into the dust.
But Poland was disrupted by outside forces, its enemies were the mercenaries of the tyrant kingdoms and empires of Europe; its sons and daughters died in the trenches and on the battlefields by the thousands rather than submit to their beloved country being annihilated as a nation. But Ireland, what of Ireland? It is the trusted leaders of Ireland that in secret conclave with the enemies of Ireland have agreed to see Ireland as a nation disrupted politically and her children divided under separate political governments with warring interests.
Now, what is the position of Labour towards it all? Let us remember that the Orange aristocracy now fighting for its supremacy in Ireland has at all times been based upon a denial of the common human rights of the Irish people; that the Orange Order was not founded to safeguard religious freedom, but to deny religious freedom, and that it raised this religious question, not for the sake of any religion, but in order to use religious zeal in the interests of the oppressive property rights of rackrenting landlords and sweating capitalists. That the Irish people might be kept asunder and robbed whilst so sundered and divided, the Orange aristocracy went down to the lowest depths and out of the lowest pits of hell brought up the abominations of sectarian feuds to stir the passions of the ignorant mob. No crime was too brutal or cowardly; no lie too base; no slander too ghastly, as long as they served to keep the democracy asunder.
And now that the progress of democracy elsewhere has somewhat muzzled the dogs of aristocratic power, now that in England as well as in Ireland the forces of labour are stirring and making for freedom and light, this same gang of well-fed plunderers of the people, secure in Union held upon their own dupes, seek by threats of force to arrest the march of idea and stifle the light of civilisation and liberty. And, lo and behold, the trusted guardians of the people, the vaunted saviours of the Irish race, agree in front of the enemy and in face of the world to sacrifice to the bigoted enemy the unity of the nation and along with it the lives, liberties and hopes of that portion of the nation which in the midst of the most hostile surroundings have fought to keep the faith in things national and progressive.
Such a scheme as that agreed to by Redmond and Devlin, the betrayal of the national democracy of industrial Ulster would mean a carnival of reaction both North and South, would set back the wheels of progress, would destroy the oncoming unity of the Irish Labour movement and paralyse all advanced movements whilst it endured.
To it Labour should give the bitterest opposition, against it Labour in Ulster should fight even to the death, if necessary, as our fathers fought before us.
Last updated on 14.8.2003


The number of online shoppers around the world is growing exponentially. A recent survey has shown that by 2016, online shoppers are expected to spend around $327 billion per year. This is estimated to be more than what is spent on prescription medications yearly. As of now, around 45 percent of shoppers, in the US, prefer shopping online, to shopping at retail stores. To attract more customers, e-retailers are coming up with many innovative ideas. Here are the latest trends in the e-commerce industry, which are adopted by e-retailers.
Social networking is the latest mantra of success, and e-retailers are not staying away from it. These businesses are trying to increase their customer base by make the customers more involved in the business. For instance, the e-retailer 'Modstock' considers public opinion while refilling their inventory. They have come up with a 'Be the Buyer' program, which is an online poll on a social media site. By participating in this poll, customers can give their opinions on what items should be restocked in the company's shopping website. This allows the customer to buy their choice of items, from the website. This ensures that the customers are happier, and it results in increased sales for the businesses.
Customers who shop online may not always find the merchandise of their choice. To prevent this disappointment, the online retailer 'zazzle.com' has come up with the idea of customization. Shoppers at Zazzle, can upload their own images onto the site, and create personalized merchandise. The shoppers can also customize the items, which are already present in the website. The can also buy the merchandise created by other users. Users can also open up their own shops at Zazzle and decide the royalty that they would like to receive on each sale. This opens up more opportunities for creative people, and drives more business to your website.
Providing personal subscriptions to the user according to his needs and demands is a great way to spice up your business. This is what the ecommerce retailer 'Birch box' has been following. This online cosmetic store sends its customers, beauty samples worth 10 dollars every month. This marketing trend is helpful in strengthening the company-customer relationship. It also serves as a mode of additional revenue for the website, as companies have to pay the website to be featured in such samples.
Collaborating with big names in the industry will serve as an additional boost to promote your business. The online retailer 'Rent The Runway' is a great example, which showcases the benefits of collaboration. This is a website, which rents designer clothing to woman. The site has a loyal following of more than one million members, and it is described as the 'Netflix for Fashion'. Women who cannot afford costly designer wear can rent these dresses at a price, which is affordable to them.
About the author: Mike is an expert in online marketing and strategies for new business startups and ecommerce sites looking to generate growth online.


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A weird, funny and creative short about Nikola Tesla's vision and goal of providing free electrical power for all to utilize. The short has an impressive aesthetic and blend of 16mm black-and-white film and stop-motion animation.
CAUTION: the short contains numerous cuts and flashes of bright lights that can be disorienting and possibly seizure inducing for certain viewers.
Both the short and director Matthew Rankin's behind the scenes featurette can be viewed on Vimeo.
To those who haven't seen this yet, be aware that if you are expecting plenty of basketball action, you'll be disappointed. This movie is more about the inner workings of the business of basketball (like Moneyball was to baseball): draft picks, sponsors, etc.
It may sound uninteresting at face value, but thanks to the work of the cast, McCraney's script and the direction of Steven Soderbergh, High Flying Bird makes it interesting. Not compelling, but interesting nonetheless.
In closing: A fun, fast-paced and entertaining adventure. Can't wait for the sequel!
The tale of a group of young prehistoric creatures on a long, dangerous journey to a safe haven (The Great Valley) is just as engaging, touching and entertaining as it was when I saw it as a kid.
I've been a lover of cinema ever since I was a kid. Favorite genre is comedy, but I don't mind watching an action movie, drama, or animated feature.
In my spare time, I also DJ and take pictures.


I turned the big 25! i seem to be one of the few that don't mind growing a year older! every year is a gift from God. I have grown so much personally, spiritually, and begrudgingly physically this past year. I have learned to love myself for who i am and have learned to view the world in a much different way taking and enjoying my life one day at a time! I am HAPPY! and that is something i never thought i would be able to say!
Hopefully i will be opening up my Etsy store soon Happy Home Antiques! i have have some great stuff to list!


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Hollywood Fringe Festival – "Scarlett Fever"
Posted by Christine Deitner | 27th Jun 2019 | Festivals, Hollywood Fringe 2019, Los Angeles, Review, United States of America
L to R: Sara Carpenter, Talia Goodman, Cassi Schiano in "Scarlett Fever" at Hollywood Fringe Festival. Photo by Rich Clark.
Kick Boom Theater Company launches its inaugural production Scarlett Fever at Hollywood Fringe Festival, created and directed by John Wuchte – and if you are in Los Angeles during its run, this is about as good and magical as it can get, friends. Wuchte takes us on a uniquely cohesive physical and musical journey into the mythic quest for the actress to play Scarlett O'Hara and ends up taking us into a surprisingly internal 'all things Hollywood' experience that resonates quite soundly today. With music created by Wuchte & award-winning composer Michael Teoli that is provided live thanks to Wuchte, Kent Jenkins and Gordon Wimpress, 8 actors deliver a performance you won't want to miss.
L to R: Olivia Cordell (as Kay Brown), Austin Gold (Myron Selznick), Max Udell (David O. Selznick) in Scarlett Fever. Photo by Rich Clark.
The cast includes Max Udell as David O. Selznick, Austin Gold as Myron Selznick (David's brother), Olivia Cordell as Hollywood talent scout and agent Kay Brown (who was integral in obtaining the rights for "Gone With the Wind" and in launching the talent search we witness here), Deja Bowen as Louella Parsons, Joshua Rivas as Hedda Hopper (complete with fabulous, outrageous hat), and three Scarlett hopefuls played by Cassi Schiano (Scarlett 1), Talia Goodman (Scarlett 2) and Sara Carpenter (Scarlett 3). Though Wuchte started the show by noting he just met his 8 actors a mere 8 weeks prior, it feels as though they've been working together for years. It's a quiet yet ferocious piece that brings the physical together with the vocal [both spoken and sung] in a way that never feels forced or manufactured. With 8 black chairs, suitcases that take on characters of their own when the lights that are hidden inside of them are used to tell the story, the actors and the music more than filling the space – they take us on an unexpected emotional journey.
Deja Bowen (Louella Parsons) and Joshua Rivas (Hedda Hopper) in Scarlett Fever. Photo by Gregory Connor.
Maybe it's just me, but the hoops [pun not really intended] the three Scarlett want-to-be figures jump through reading like headlines torn from Variety this week. Once the Selznick brothers are won over to the idea of producing the film, it is Kay Brown's role in one drum-fueled chant to remind them that they are not looking for a girl – they are looking for a woman. Later on when the Scarlets have each have their turn at trying to win Selznick over [it is very tempting to try to pin down the famous actresses portrayed by Sara Carpenter and Talia Goodman along with the one unknown hopeful portrayed by Cassio Schiano who gives us the most nearly painfully innocent take on the process] they join together to ask Selznick what he wants from them/sees in them/needs from them right now while Selznick casts his own larger than life shadow on a brick wall to the right and we don't need to stretch our minds that far to imagine that this opportunity drove actresses nearly mad with the desire to win a role that gave them more than one thing to play. In the film, Scarlett is, after all, both infuriatingly selfish and ultimately sympathetic – given her circumstances and the change her character undergoes.
But nevermind the film and the weight it has carried with it since its premiere all those decades ago. Let yourself forget what happened and imagine the possibilities and the panicked rush to land the most coveted role of its time. The gesture work, energy and sheer presence of this piece are more than worth your time.
https://thetheatretimes.com/wp-content/uploads/2019/06/teaser7_663.mp4
John Wuchte began his career in New York City where he was the Artistic Director of RAKKA–THAMM!!! Theater Company through the '90s. Each summer he would adapt Greek tragedies filled with chant and song accompanied by live drumming and would perform outside in Washington Square Park. This is when his Tribal Acting method took shape. He wrote and directed Vivian Vance is Alive and Well and Running a Chinese Take-Out. His production of Claire Z. (an adaptation of The Visit) was performed at Sacred Fools Theater Company and received an L.A. Weekly nomination for best adaptation.
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The Cape Sienna Phuket Gourmet Hotel & Villas is conveniently located along the Millionaire's Mile of Phuket, in Patong. Its exclusive location on Kamala beach offers guests unmatched views of the sea that will make your holidays a memorable and romantic experience. A 30-minute drive will take you to renowned golf courses, and a short 10-minute drive will allow you to discover the evening entertainment of Phuket FantaSea, the best cultural theme park of the area.


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Am I the Only One?
Why the woman in 'Hotline Bling' is my 2015 hero
Lyz Mancini
Disclaimer: This may automatically get "Hotline Bling" stuck in your head forever and for that…I'm not sorry. It's been stuck in mine for weeks.
We've all been there in some capacity. You fall for a dude, and things fall apart because of timing. Sometimes this means he's not over his ex, sometimes he's too into our "swipe left" culture, and sometimes he's Drake and like…tours a lot and stuff. Then you spend maybe months wondering what he's thinking, and here comes Drake with his point of view of this exact scenario and it's, well, it's not one I agree with.
Think about "Hotline Bling" as a kind of play: It's about an ego-bruised dude (not Drake IRL necessarily, more like a character he's playing) who truly expected his girl to sit around and wait for him, literally from inside her house, calling him late at night from time to time for late night hook-ups. When you think about it that way, isn't the hero of this play definitely the girl? Here's what she does: she starts going out more with her friends, moves on, and stops calling up her one-time hook-up on the reg. That's all stuff that you would tell your best friend to do, instead of hanging by the telephone, right? Maybe she occasionally slips up and calls him on his cell phone (as opposed to, I guess, a house phone) after a few glasses of champagne. But that's okay. Emotional relapse can be a part of recovery.
Let's look at it from his point of view. Maybe for a while, she stayed home pining for him. Maybe read some books she had been meaning to read, baked cookies with her mom, Taylor Swifted it up. Then, she started noticing his very active social media life. The Instagrams of after-parties, flirts with Twitter babes, maybe a TMZ post or two, Lil Wayne's Snapchat stories…and she started to get bored. So she went out and bought a badass dress, some heels. She called that girl from work who is always inviting her to happy hour. She started to feel like she was getting her self back. She started having fun. She started thinking of him a little less.
There's the complaint that she's hangin' with some girls I've never seen before. But after a break-up, that's what you do. You find new friends, or maybe mix up old friends with a new squad. She's running out of pages on her passport because she's flying all over the place. I mean, she sounds like she's pretty much killing it.
When Drake sings, You should just be yourself, right now you're someone else, I would like to argue that he probably never knew her. Our selves aren't these fixed points that we're meant never to stray from. They're always changing. We're always adding on new things and refining parts of ourselves. There's a core part of you that's you no matter what you do. You want to be true to it, but that doesn't mean you can't try new things or change the way you approach life. In fact, you should.
I think we could all learn a little from this babe's "screw this, I'm moving on" attitude. The thing is, she might call him from time to time late at night, but he's the one answering. She's the real hero of the story. I promise.
By Lyz Mancini
Popular in Am I the Only One?
Being in public without fear of harassment is my right, but not my reality
Matt Bomer dancing to "Hotline Bling" on 'AHS' was the best part of the season
Why Annie Savoy from "Bull Durham" is my feminist hero
Gloria Steinem just explained why 2015 was a pivotal year for feminism
Why we should start saying "congrats" to our newly single friends—not "I'm sorry"
Why heartbreak and music go hand in hand
Philly police department creates "Hotline Bling" parody to help prepare for Storm Jonas
After therapy and lots of personal growth, these are my romantic intentions for summer 2019
My partner had erectile dysfunction—but it was the best sex of my life
Why taking my daughter to a Beyoncé concert is a necessary rite of passage
John Oliver told us why his wife is his hero, now she's our hero, too
Everything you need to know about sleeping with another woman for the first time
Why fighting in my relationship is OK
This cat dancing to 'Hotline Bling' is all of us
And finally, there's this pug dancing to 'Hotline Bling'
Why Internet friends were so important to me in 2015
Why work friends are important in and outside of the workplace
When Harry Met Sally can still teach us about love 30 years later
Sam Smith and Disclosure just did a super dreamy cover of "Hotline Bling"
All Topics in Am I the Only One?


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Bayou Pawn Shop is located at the address 509 Saint Mary st Ste H in Thibodaux, Louisiana 70301. They can be contacted via phone at (985) 447-5142 for pricing, hours and directions.
Bayou Pawn Shop has an annual sales volume of 0 - 500K. .
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Bayou Pawn Shop was founded in 1994, and is located at 509 Saint Mary St Ste H in Thibodaux.
Bayou Pawn Shop can be found at Saint Mary St 509. The following is offered: Jewelry Retailers. The entry is present with us since Sep 10, 2010 and was last updated on Nov 14, 2013. In Thibodaux there are 4 other Jewelry Retailers. An overview can be found here.