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HomeModel 1900
SERIAL# NONE
The first auto loading version of the Mondragon rifle. This one is marked "Modelo No. #3″ "1900", a carbine in 7 x 57mm Mauser
In the picture below, you can see the lineage from the manual bolt action rifle to the auto-loading version. The upper gun is an early 1890's model straight pull rifle. The lower gun is the Model 1900 semi-auto carbine.
The model 1900 utilizes gas tapped from the muzzle end of the barrel to drive a piston to which the bolt is attached (see Gas System for details) and cycles with the aid of a return spring. This system is the logical progression from his 1890 straight pull mode. All semi-automatic guns are basically a modified straight pull action. Just add high-pressure gas or recoil to move the bolt back and a return spring to reload.
An interesting design feature of the Model 1900 is this cam system (below) used for charging the weapon. Pull back the charging handle, and this cam lets go of the return spring making it very easy to reload. Once the weapon is loaded, reloading is automatic. In weapons of today, one must overcome the return spring to reload. In the later Mondragon models (FSK15) this feature was removed and a manual bypass was provided for…pity because the original looks cleaner.
The fact that there is no serial number and the markings on this gun are "Modelo No. 3" Model 1900 and the solid bolt handle which is only seen on the first designs.
This gun says "prototype" to me.
Original Patent
Many of The Mondragon rifles have all been linked to this patent drawing, but this drawing is for the Model 1900 only. Only 2 patents were taken, one for the manual reloader and one for the semi-auto 1900.
In 1903, the Model 1900 was tested by the British army, along with rifles of other nations. The result was to be a classic case of pushing an immature design for sale before the bugs are worked out. Improper heat treating of firing pins and the extractor caused failures after 5,000 rounds. The ammunition supplied for the demonstration was not made to specs and caused failure to feed malfunctions in the autoloading mode. The large opening on the RH side, where the bolt travels, allowed sand and dirt into the feed mechanism. The large hole exposing internal rails, where the bolt travels, used for reloading and ejection has always been a problem for semiautomatic rifles. With the exception of the exposed bolt race and magazine, the other issues were remedied in the Model 1908 (see Model 1908 section). note# A recent article in Firearms News featured a 10,000-round showdown between the M16 and AK47 designs, and both guns had failures after about 5,000 rounds.
Other Prototypes Based on the Model 1900
Photos courtesy of Royal Military College of Canada Museum/Museé Du Collége Royal Du Canada.
My Observation: Does this magazine look like it should be for a rimmed cartridge?
Specification Sheet for the Model 1900
Country of Design: Mexico
Designer: Manuel Mondragon
Calibers: 30-30 Winchester, 6.5 Mondragon, 7.65 x 54mm Argentine and 7x57mm Mauser
(The 30-30 was a one time chambering presentation piece for President Diaz, the 7.65 cartridge was for the Argentine Army)
Type of reloading mechanism: Semi-automatic, Gas operated
Magazine capacity: 6, 8 or 10 rounds, depending on caliber
An 8 round en-bloc clip was used for reloading. The disadvantages of the en-bloc clip must have been discovered early on because this is the last Mondragon designed gun to utilize this method. The Model 1908 and subsequent used either stripper clips or a removable magazine.
Quantity: Approximately 200
Years made: Late 1890 – 1900
Manufacturer: Swiss Industrial Company (SIG), Neuhausen, Switzerland
Entered service: Only a Trials gun or proof of concept
Weight: 7lbs 12 oz
Barrel length: 21.5 inches
Total length: 42 inches
Sights: No graduation on long-range sight, battle sight is probably 400
Serial Number Range: 1-200 (if any)
NOTE: Some of the Model 1900 rifles appear to have repetitive serial numbers. A new set of serial numbers appears to have be assigned for each caliber. It is possible to see two serial #3's – one in 7 x 57mm Mauser and one in 7.65 x 54mm Argentine, as an example.
US Patent Applied for on: August 8, 1904
US Patent (#853,715) granted on: May 14, 1907
The Model 1908 falls under the basic patent of the Model 1900 "with improvements"
Known examples…………………………………………………………………………………………5


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Anyone For Golf? Veterans Gather For Fundraising Event At St Andrews
Former service personnel gathered at the Home of Golf for the annual event organised by Legion Scotland.
David Sivills-McCann
9th May 2019 at 3:37pm
Former service personnel have gathered in Scotland to raise money for veterans through an annual golf event.
St Andrews, otherwise known as 'The Home of Golf', was the scene of the Silver Poppy competition, run by Legion Scotland.
The organisation supports thousands of people with their lives after the military.
Deaf Awareness Week: RBL Urges Veterans With Hearing Loss Or Tinnitus To Seek Help
For most on the formidable 'New Course', it is the highlight of Legion Scotland's social calendar.
The thick rough on the New Course.
Mark Davies, a member of the charity's Alford branch, said: "As soon as you arrive, you say 'oh hello!'.
"You maybe played with them five years ago, two years ago and you always get a smile and a nod."
The Chairman of the Kelso branch, Steven Patterson, said he loves the camaraderie of the day:
"I've met a couple of new friends on the course and that's what the Royal British Legion's all about."
Poignant Poppy: Pupils Given New Interactive History Lesson
With prizes and bragging rights at stake, there is always a friendly rivalry.
Help for Heroes, BattleBack, Veterans First Point and Poppyscotland have also taken part.
For Poppyscotland's Head of Welfare Services, Gary Gray, the event promotes an important message.
"The shape of the forces may be changing," he said. "But the demands of today's men and women who have served in the forces aren't changing - if anything they are becoming more multiple and complex, and Poppyscotland is here for them at every turn."
Browse hundreds of jobs for ex-forces
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Ellie Wellborn: Seeking Peace
5 Mar, 2019 David Bublitz Featured, Main, Student Life, The Cameron Collegian 0 0
International language major Ellenette (Ellie) Welborn lived in four countries by the age of 22 and speaks the languages of three—Spanish, Indonesian and English.
On a busy week Ellie's room shows lose scrap papers, open notebooks on the floor, socks with no match.
But on a relaxing week, she places elephant statues prominently, travel mementos on a memo board along with maps and photos of friends.
Years before and over 9,000 miles away in Jakarta, Indonesia, Ellie was unable to decorate her room, leaving it to her step-mother.
"Pink—everywhere," she said. "It looked like a newborn baby's room. Pink table, pink rug … Pink!"
Ellie was eight when she moved to Indonesia. Although knowing three languages can be a blessing, it can also be difficult for her.
The uhs, ums and wild hand movements, the look of annoyance on her face show the sometimes frustrating nature of being trilingual.
One of Ellie's mentors and Director of Student Development at Cameron University Dr. Pruchnicki, believes that the rare downsides to knowing three languages can still benefit Ellie.
"Ellie may be quiet," she said. "She may not say as much, but when she does say things people listen. She says things that are important."
The difficulty to elaborate in a single language is only a slight drawback for Ellie.
If Ellie gains what she considers a once in a lifetime experience of joining the Peace Corps, she will teach young children who struggle with language, not unlike her, as a child.
The Peace Corps mission is to promote world peace and friendships by fulfilling three goals:
1.To help the people of interested countries in meeting their need for trained men and women
2.To help promote better understanding of Americans on the part of the peoples served
3.To help promote a better understanding of other peoples on the part of Americans
The Peace Corps also has core expectations for volunteers, stating on their website they must "represent responsibly the people, cultures, values, and traditions of your host country."
With Ellie having lived in Indonesia before, Pruchnicki believes Ellie already embodies this Peace Corps expectation.
When Ellie thinks back to her time in Indonesia as a child, she considers it pleasant despite the obstacles she had to overcome in moving to a country she'd never heard off in a house with a step-mom she'd never met.
Before moving to Indonesia with her father and stepmother, Ellie lived with her grandmother in Argentina. There, she was the only child.
"The first month that I moved to Indonesia," she said. "My dad went on a work trip and was gone for a whole month. He left me with my new family that I just met. I was a troublemaker—mainly because I didn't know the rules."
Ellie unwillingly respected the authority of her stepmother when first moving to Indonesia as an adolescent.
In Argentina, with her grandmother, there were imaginary friends to race on her bike in the countryside. In Indonesia, there were strict rules of no playing outside because of the potentially dangerous nature of the city and no sleepovers with friends.
But also in Indonesia, there were personal drivers and live-in maids who swept, mopped, cleaned laundry and cooked food.
As a child, Ellie didn't consider herself particularly religious, but Indonesia has the largest Muslim population in the world with approximately 225 million Muslims.
She said she'd prayed in times of hardships, but never claimed a specific religion.
"In the past, I prayed to God," she said. "I didn't necessarily consider myself Catholic or Christian. I just prayed to God. In my head, I still prayed to the same God [with her Muslim family], I just did it a little differently."
After four years living in Indonesia where hijabs were the norm, Ellie moved to Oklahoma where bedazzled jeans and cowboy boots were in fashion.
"I remember the first couple of weeks I moved to Duncan," she said. "These popular girls thought it was so cool I came from the jungle. There are jungles in Indonesia, but I lived in one of the world's biggest cities where there's more traffic than trees. So, if you consider giant buildings a jungle, then I guess I did."
At this point in her life, with graduation a few months away, she faced a single interview that could determine her future.
In January, Ellie completed her application to teach abroad with the Peace Corps. A day after being rejected for a position in the Dominican Republic, Ellie received confirmation for an interview for a position in a country she's already been—Indonesia.
During the interview Ellie was asked by a Peace Corps Placement Specialist about past and current experiences and skills such as teaching, tutoring and mentoring others.
Pruchnicki believed the position was destined for Ellie.
"Ellie prepared herself for her interview," she said, "it was all Ellie. We were just there giving her encouragement and tips along the way.
"Ellie [will] got hired because Ellie's awesome. She had all the skills and experience and passion they were looking for."
And so, the waiting began … Months of preparation and practice boiled down to a 90-minute interview.
Initially, Ellie would know within two months if she was accepted. But a day later Ellie received her acceptance letter to serve as an English Teacher and Teacher Trainer in Indonesia.
"With Ellie, her actions speak as well," Pruchnicki said. "If you looked at everything she's involved in and the things she's passionate about, they totally aligned with the mission of the peace corps. It was such a perfect fit."
Seven months from now, Ellie will fly 38 hours to Indonesia with a few suitcases containing all her clothes, photos and hopefully matching socks.
For two years, she will stay in one of the most densely populated areas in the world—the island of Java. There, she will live with a host family, most likely in a traditional Javanese house.
Even though volunteers will be living in rural areas, the Peace Corps website states that there may still be large populations of people.
Pruchnicki believes that despite Ellie's nervousness, she is prepared.
"Whatever Ellie's expectations are," she said, "nothing is going to prepare her for what actually happens, but she has the skills to adapt to whatever gets thrown her way."
Ellie is prepared for the next chapter of her life and believes that living abroad has helped prepare her.
"I've lived in different countries," she said. "But, I don't have a favorite. I loved living in all three. They each brought new perspectives to me."
Pruchnicki said she knows Ellie will go on to do great things with the Peace Corps.
"I don't think we'll just see a change in Ellie," she said. "I think we'll see a change in where been she's assigned and see a positive impact there."
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Dunn, Montalvo named among Cameron's finest
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0 thoughts on "Ellie Wellborn: Seeking Peace"


I am often asked for my advice and for resources . . . everything from artists/photographers to capture lasting memories . . . to nutrition . . . to end of life services. Here is a start. I will keep adding to these resources and if you have some requests please let me know.
These artists have done some incredible work for me.
There is nothing more difficult than saying goodbye to the furry love of your life. These resources can make it a little easier.
Euthanasia in the comfort and privacy of your home.


An armoured tower like a castle keep, surmounts the ship for long distance gunfire control, all or nothing armour, elegant lines, high speed and the latest radar. North Carolina became the most decorated U.S. battleship of WW2, engaging in almost every battle of the Pacific war. Washington gained the distinction of being the only U.S. battleship to sink an enemy Battleship, in a battle against the Japanese Kirishima. Washington finished up being scrapped in 1962, while North Carolina was saved from the scrappers torch and became a museum moored in Cape fear river, Wilmington NC.
This 1:72 scale hull with Anchor positions, Stern sponsons, Outboard shaft exits and ship's side plating moulded in.
3,100mm long and 457mm wide.


Pokemon GO became a global hit in no time, but not thanks to its detailed tutorial and crystal clear mechanics. Thankfully, hundreds of Pokemon trainers all over the world are already putting in a lot of work into figuring out the game's tricky rules and regulations and they've just had a breakthrough. More specifically, a Pokemon GO testing group called the Silph Road recently came to the conclusion that regardless of how much CP a certain Pokemon has and regardless of how many times it's been powered up, it has certain fixed stats that are semi-randomly determined and cannot be changed. These attributes are the base attack, base defense, and base energy and unfortunately, all three are hidden from the players.
While base attack and base defense are self-explanatory, base energy determines how quickly can a Pokemon fill its special attack meter. Despite being somewhat random, the ranges of these three stats are determined by species, so e.g. Onyx will always have a higher base defense than Golbat even if both are on the same level. The Silph Road concluded that rarity doesn't necessarily correlate with combat viability as some incredibly rare Pokemon like Ditto always have horrible base stats and aren't worth investing resources into. Furthermore, the strongest pocket monsters in the game are either incredibly rare or cannot reach their full potential without a massive time investment. These include Lapras, Snorlax, Exeggutor, Mewtwo, and Articuno. As suspected, the Silph Road testers concluded that Vaporeon is the best bet for your Candy as it's the 13th strongest monster in the game despite requiring only 25 Candy to evolve from Eevee.
Apart from the above three, another hidden yet incredibly important stat featured in Pokemon GO is attack duration. As the game's combat isn't turn-based like in the older titles, you won't necessarily be looking for a Pokemon who has the most powerful attack, but one can dish out the highest damage per second (DPS) As suspected, Vaporeon once again proved to be one of the fastest damage-dealers out there. Another important find is the fact that while quick attacks require only a single dodge, some longer special moves can only be avoided with multiple nicely timed dodges. More info regarding the game's mechanics is expected to follow soon as the Silph Team is still conducting tests.


Rob and Mike here. We're asked, many times, why a user does not authenticate against a local domain controller in the same site when logging on across a forest. We've setup the most common scenario to help explain how domain locator works for user logons across a forest.
Let's explain the typical scenario in which we see this problem: The scenario starts with two separate Active Directory forests: contoso.com and litware.com. Each forest has a forest (i.e. kerberos) trust to the other. The contoso.com forest has one Active Directory site name CHARLOTTE. The litware.com forest contains two sites: REDMOND and CONTOSO. Administrators in the litware.com forest created the CONTOSO site and subnet to support logons for litware.com users from terminal servers in the contoso.com forest.
Users from litware.com logon to a terminal server existing in the contoso.com forest. However, Users experience a slower-than-usual logon, and the LOGONSERVER environment variable shows the name of a remote domain controller in the REDMOND site rather than the domain controller from the CONTOSO site.
However, administrators from the litware.com domain expect users from their domain (logging on contoso.com terminal servers) to authenticate using the domain controller located in the CONTOSO site. The CONTOSO site is the same physical locations as the terminal server. Authentication should occur in the local site and should be fast, right?
It is important to know how a Windows computer selects a domain controller. The computer, during startup, determines the Active Directory site in which it belongs. Windows accomplishes this by examining the subnet of its current network configuration. Then, the computer queries a domain controller that hosts the computer object(using the Windows API DsGetSiteName). The domain controller answers this query with the name of the site associated with the computer's currently configured subnet. This is all done by the NetLogon service, which runs the DC Locator code at boot and periodically rechecks the domain controllers' location.
Windows will attempt to use the closest domain controller (on the same subnet) to the local computer for authentication. Windows finds the closest domain controller by using DNS and SRV resource records.
The DNS server's response to the above request includes a resource record for every domain controller in the user's domain. Since the client receives the list of domain controllers in no particular order this result is usually the cause as to why the domain controller locator does not use the closest domain controller for authentication.
The Netlogon service of a domain controller is responsible for dynamically registers the _ldap service resource records with its configured DNS server. This registration includes the site specific and domain specific _ldap records.
Our scenario involves a terminal server, which allows multiple users sessions. This is a great way to take network captures of user logon related issues by sing one of the logon sessions to take the network capture. It is always best to clear the DNS and NetBIOS name caches before starting a network capture. This ensures the network capture includes name resolution. You can clear these caches by using IPConfig /FlushDNS and NbtStat –R from a command window (under an elevated command prompt for Server 2008 and Vista).
Here is a snippet of the output of the network capture.
The results of the network capture show the domain controller locator attempts to locate a domain controller in the site with the same name as the site of the computer; but in the user's domain (frame 3). The DNS server responds with no such name. This is correct. The Litware.com forest has only two sites: REDMOND and CONTOSO. Frame 4 queries for an SRV record a second time; however, this time the query does not include the site name of the computer (_ ldap._tcp.dc.msdcs.litware.com). The DNS response provides a positive answer to the second query. The answer includes a _ldap record for each domain controller in the litware.com domain (the user's domain).
We've covered the background information and the problem. Now, let's talk about how to fix it. We can accomplish this by using Active Directory Sites and Services to rename the CONTOSO site in the litware.com domain to CHARLOTTE (the name of the site hosting the computer in the contoso.com domain). Active Directory site configuration is stored in the configuration partition of Active Directory. Renaming the site creates a change and you'll want ensure this replication converges– especially to the litware.com domain controller that is now located in the CHARLOTTE site of the litware.com domain. After Active Directory replication completes, then restart the Netlogon service on the litware.com domain controller in CHARLOTTE site (in the litware.com domain). This registers the service resource records in DNS for the domain controller, including the new site in which it belongs.
Let's take another network trace of a litware.com domain user logon from the terminal server in the contoso.com domain.
The same DNS query from figure 1 appears in figure 2. Frame 3 shows the domain controller locator attempting to find a domain controller service resource record in the CHARLOTTE site of the user's domain, litware.com. However, the difference between figure 1 and figure 2 is the DNS response. Figure 1 returned a negative DNS response because a resource record for the domain controller did not exist in the CHARLOTTE site in the litware.com domain. But, figure 2 shows a positive DNS response (frame 5) for a service resource record for a domain controller in the CHARLOTTE site of the litware.com domain.
After renaming the sites so that they match in both forests, the terminal server in the contoso.com domain successfully located a domain controller covering the CHARLOTTE site for litware.com domain. Ideally, in this scenario you would also want the litware.com domain controller covering for the contoso.com CHARLOTTE site to be on the same subnet as the contoso.com terminal server. This helps expedite litware.com logon requests originating from the terminal servers. Regardless, the configuration provides a way to distinguish a specific domain controller for use with logons that span across forests.
Great post, it really makes it nice and clear to understand and fix.
The DNS server's response to the above request includes a resource record for every domain controller in the user's domain. Since the client receives the list of domain controllers in no particular order this result is usually the cause as to why the domain controller locator does use the closest domain controller for authentication.
…shouldn't it say "does not use" in the second sentence?
Great catch bday! That has been fixed.
Great info on a real-world issue – 'how to effectively use multiple forests?' Great work, bloggers!
This article does a great job of explaining authentication between domains using a forest trust.
I'm trying to fix slowdowns when the trust is between domains with no forest trust, i.e. External.
We see the same behaviour as above in our traces but the trusted domain controllers are not accessible to members of the resource domain. DNS is available because the trusting domain DCs are forwarding the requests through. In the end the devices in the trusting domain spend a good deal of time, ~20 sec, trying to contact DCs in the external trusted domain for Kerberos authentication. Only when they fail entirely will go to their own DC.
Ok, so if you can't match the site names, it's an external trust, and are using DNS forwarding (so you can't simply put up a stub domain) what are your options?


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Q: Increasing mesh details (additional tesselation) I have the following problem (as a part of a solutions to another problem :)). I have a triangulated mesh with some triangles marked. It is needed to split marked triangles to a four smaller ones like this:
   /\             /\
  /  \           /__\
 /    \   -->   /\  /\
/______\       /__\/__\

That splitting of marked triangles leads to the need to splittriangles adjacent to marked ones too (one is marked, another's just adjacent and the last remained intact):
    ____               ____
   /\   |\            /\  /|\
  /  \  | \          /__\/ | \
 /    \ |  \  -->   /\  /\ |  \
/______\|___\      /__\/__\|___\

Is there some C/C++ library that can be useful for it? Also, it is useful to keep adjacency data, so it would be nice to update that adjacency data after splitting. It would be nice, even if the library does not do the job, if it provides a convenient interface to work with that kind of data (triangles, adjacency).

A: Check out VTK C++ library.
It has a class vtkPolyData that can handle the operations that you mention. Particular member functions to check out:

*

*InsertNextLinkedCell

*InsertNextLinkedPoint

*ReplaceLinkedCell

Read the linked documentation page to understand how to use it. The class can be used for any type of cells, not just triangles. But you can restrict your use to just triangles.

redpajama_set_name: RedPajamaStackExchange


Iranian comedian who has toured with the comedy group Axis of Evil and has made several television appearances. He has also been in the films The Interpreter, Friday After Next, and Dragonfly and in the Disney TV movie Descendants.
He was raised in the San Francisco Bay Area and received a bachelor's degree in political science and Italian at UC Berkeley. He was going to pursue a Ph.D at UCLA, but decided to pursue his dream of being a comedian and an actor.
He is quite involved in philanthropy, working with organizations such as the Persian American Cancer Institute and the International Society for Children with Cancer.
He married an Indian-American lawyer in 2006 and had a son and a daughter with her.
He made an appearance in the movie 13 Going on 30, starring Jennifer Garner.


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Judicial Profile: John Herlihy
By Shannon Lafferty | January 28, 2002 at 12:00 AM
Court: Santa Clara Superior Court Appointed: January 1990 by Gov. Deukmejian Date of Birth: Oct. 10, 1997Previous Judicial Experience:Santa Clara Municipal Court, 1983-90; Santa Clara Municipal Court Commissioner, 1980-83 Law Degree:: Hastings College of the Law, 1974 Trial attorneys describe Judge John Herlihy as a judicial trifecta. Attorneys say the popular Santa Clara Superior judge is smart — he makes tough decisions and backs them up with practical legal analysis. He's fair — he closely reads each side's briefs and often takes the extra time to hear arguments on crucial points. And he's nice — attorneys say he hasn't forgotten what it's like to stand on the other side of the bench. "He is, in my mind, a trial lawyer's judge: even-tempered, engaging, accommodating when necessary. He has a very good command of the facts and issues but lets the trial lawyers do their job," said John Winchester III, a partner at San Jose's Robinson & Wood. A former deputy district attorney and civil litigator, Herlihy has handled civil trial and law and motion calendars for nearly a decade. And lawyers say he has grown into one of Santa Clara's most competent civil trial judges. "I really found him to be a user-friendly judge," said Arthur Casey, another Robinson & Wood partner. "He is a great trial judge. He is very strong on evidence. He is very knowledgeable. I think he's fair. He listens to both sides." Casey, who defended a premises liability claim in Herlihy's courtroom in May, said the judge expertly handled crucial evidentiary questions, taking the time to hold hearings and closely consider the issues. "Some judges see it as taking too long. Once they've made up their minds, they won't go back and rethink their decisions," Casey said. "You always knew Herlihy went back and did his homework." Casey said Herlihy was willing to put in the extra hours during the trial, having attorneys fax him briefs during the weekend and being ready to rule by Monday. "I think there is some perception in the plaintiffs bar he may be conservative, but I didn't find that. I think he was fair," Casey said. Morgan Hill solo practitioner Steven Levy said Herlihy takes a practical approach to the law. Herlihy often starts law and motion arguments with questions that cut right to the heart of the legal issues. Levy said that doesn't mean the judge has made up his mind, but it gives lawyers some insight into his thinking on the matter. "He is one of these guys who can go right to the proverbial bottom line," Levy said. "To me that's practicality. Can you weed through all the crap, all the muck and boil it down to, 'Here's what I'm thinking. Here's what I am concerned about. Here's my question.'" Levy argued and then re-argued a case in Herlihy's courtroom, representing homeowners who want to prevent logging trucks from using a road that paralleled their property. Herlihy initially ruled that recreational uses of the roadway by motorcycles implied the road was public and could be used by trucks. The Sixth District Court of Appeal sent the case back and Herlihy eventually ruled that truck traffic was not included in the roadway's implied public uses. "We had enough confidence to do the second trial in front of him," said Richard Van't Rood, a South Bay solo who worked with Levy on the case. "He is one that tries to do the right thing." Levy said Herlihy's written ruling in the second bench trial was polished and well-reasoned. "I see him as someone who likes what he does and anxiously heads down there every day ready, willing and able to do the best job [he] possibly can," Levy said. Herlihy said his judicial demeanor is no accident. He says being a thorough, knowledgeable judge isn't incompatible with being a nice guy. "You can be friendly, down-to-earth," Herlihy said. "You can have a warm, fuzzy side but you have to exert control over the court. You can blend the two together." Herlihy made news in 1997 when he was removed from a high-profile insurance coverage dispute after attorneys alleged that his research attorney had a bias. Herlihy, who felt it was unjust to remove judges for their choice of research attorneys, pursued his case all the way to the California Supreme Court. He lost at the Sixth District Court of Appeal and the high court refused to hear the case. Herlihy dismisses the case as history but said he pursued the case on principle. "It suggested judges don't make the decisions. Research attorneys do," Herlihy said. Attorneys agree that Herlihy's appeal wasn't an ego trip, but rather him pursuing what he thought was right. Attorneys say that same philosophy shows in his court.
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Here's a High Impact Interval Training (HIIT) Workout for your abs.
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A Seleção Cipriota de Futebol representa o Chipre nas competições de futebol da FIFA.

Apesar de ser uma das seleções mais modestas da Europa (nunca disputou Copas do Mundo ou Eurocopas), o Chipre segue em estágio de evolução, principalmente após o surpreendente empate em 4-4 contra Portugal, em plena cidade de Guimarães.

Suas partidas como mandante acontecem no GSP Stadium, em Nicósia, a capital do país. Entre 2011 e 2013, foi treinado por Nikos Nioplias, ex-jogador da Grécia e do Panathinaikos, substituído por Pambos Christodoulou.

Principais jogadores
Sotiris Kaiafas é considerado o mais importante futebolista da história do Chipre, sendo oito vezes artilheiro do Campeonato Nacional, quatro delas seguidas (1980–81, 1981–82, 1982–83 e 1983–84, as últimas já em final de carreira), e levou ainda a Chuteira de Ouro europeia em 1976, sendo o único cipriota a receber a honraria. Pela Seleção, não teve o mesmo sucesso: foram apenas dois gols em 18 jogos entre 1972 e 1980.

Posteriormente,  Michalis Konstantinou e Ioannis Okkas (ambos com passagens pelo futebol grego) viriam-se a tornar os jogadores mais famosos da Seleção Cipriota, assim como Constantinos Charalambides e Efstathios Aloneftis.

Treinadores

Mais partidas disputadas

Elenco atual

Os seguintes jogadores foram convocados para os jogos da Liga das Nações 2020-21, contra  Luxemburgo e  Montenegro, em 14 e 17 de novembro de 2020

Atualizado até 24 de Janeiro de 2021

Dez partidas notáveis
  3 - 1 Grécia   (Nicósia, 27 de novembro de 1963, amistoso)
  2 - 1  (Nicósia, 17 de fevereiro de 1968, Eliminatórias para a Copa de 1970)
  1 - 1  (Limassol, 12 de fevereiro de 1983, Eliminatórias para a Eurocopa de 1984)
  1 - 1  (Nicósia, 22 de outubro de 1988, Eliminatórias para a Copa de 1990)
  3 - 2  (Larnaca, 5 de setembro de 1998, Eliminatórias para a Eurocopa de 2000)
  5 - 0  (Limassol, 15 de novembro de 2000, amistoso)
  5 - 2  (Nicósia, 7 de outubro de 2006, Eliminatórias para a Eurocopa de 2008)
  1 - 1  (Nicósia, 15 de novembro de 2006, Eliminatórias para a Eurocopa de 2008)
  4 - 1  (Larnaca, 11 de outubro de 2009 Eliminatórias para a Copa de 2010)
  4 - 4  (Guimarães, ; 3 de setembro de 2010, Eliminatórias para a Eurocopa de 2012)

Galeria de imagens

Ver também
 Eliminatórias da Copa do Mundo de Futebol de 2014

Cipriota
Futebol de Chipre

redpajama_set_name: RedPajamaWikipedia


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"Way Back" is a song by American girl group TLC, featuring Snoop Dogg, from their fifth studio album, TLC (2017). An ode to the group's fanbase since their beginnings in 1991, it was released as the lead single on April 14, 2017, by newly formed label 852 Musiq and UK-based independent record company Cooking Vinyl. The song was written by group member Tionne Watkins and James Abrahart alongside Snoop Dogg and was produced by D'Mile, who also wrote the middle-8 section on the extended version.

Background and promotion
On April 12, 2017, TLC announced on Twitter, "Tune into @BBNcrew tomorrow @ 12PM EST to get the first listen of our new single, Way Back. Can't wait to share it with you! #TLCgoeswayback". "Way Back" premiered on April 13 via the Internet radio service iHeartRadio.

Critical reception
Billboard described the song as having a "G-funk, R&B groove". Time stated in an article, "The pair gifted us an extra-special throwback bop for the weekend in the form of the brand-new track "Way Back," a smooth, groovy tune that marks their first release in a whopping 15 years."

Music video
TLC went on Big Boys Neighborhood to promote the single and announced a contest that would allow a few lucky fans to be extras in the video. The lucky fans were selected on April 19, 2017 via Facebook and given specific instructions for the following morning.

The music video was shot in North Hollywood, California on April 20, 2017 from 7:00AM to 10:00PM. The fans that were selected are all featured as back up dancers in the dance scene around the blue convertible car during the chorus. The video uses the extended version of the song.

The video was released on June 6, 2017 and was met with positive reviews and gained 2 million views on YouTube in 48 hours.

Track listing

Commercial performance
In the United States, "Way Back" debuted at number thirty-three on the Billboard Twitter Top Tracks chart on April 29, 2017. The song also debuted at number twenty-eight on the Adult R&B Songs chart on May 6, 2017. In its second week the song charted at number twenty-three. In its third and fourth week the song charted at numbers nineteen and fifteen respectively. In its fifth week the song rose one place, charting at number fourteen. The song entered the Top 10 in its eleventh week.

Charts

Weekly charts

Year-end charts

Release history

References

2017 songs
2017 singles
Cooking Vinyl singles
Funk songs
TLC (group) songs
Songs written by Tionne Watkins
Songs written by James Abrahart


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Movieman's Guide to the Movies
The Final Word on Blu-rays, DVDs and Movies
4K Ultra HD Review Index
Blu-ray 1080p Screen Captures
3D Blu-ray Reviews
Screen Caps
Blu-ray Release Schedule
Review: High Noon BD + Screen Caps
High Noon, directed by Fred Zinnemann (The Day of the Jackal), is a classic western-adventure featuring a top notch, and a features a thrilling finale, who's who of the 1950s from Gary Cooper to Grace Kelly to a young Lloyd Bridges.
— Olive Signature —
Genre(s): Western
Olive Films | NR – 85 min. – $39.95 | September 20, 2016
Date Published: 10/10/2016 | Author: The Movieman
Directed by: Fred Zinnemann
Writer(s): John W. Cunningham (magazine story "The Tin Star"); Carl Foreman (screenplay)
Cast: Gary Cooper, Thomas Mitchell, Lloyd Bridges, Grace Kelly, Otto Kruger, Lon Chaney, Harry Morgan, Lee Van Cleef
DISC INFO:
Features: Featurettes, Theatrical Trailer
Digital Copy: No
Formats Included: Blu-ray
Audio: English (DTS-HD MA 1.0)
Video: 1080p/Full Frame 1.33
Disc Size: 30.9 GB
Region(s): A
The myth and poetry of the old west come alive in Fred Zinnemann's classic western, High Noon. One of the great treasures of the American cinema, the film stars the legendary Gary Cooper as lawman Will Kane, a marshal who stands alone to defend a town of cowardly citizens against a gang of killers out for revenge. Engaged in the fight of his lifetime, Kane stands to lose everything when the clock strikes noon – his friends, his honor, and his Quaker bride, played by Grace Kelly in one of her first screen roles. Unfolding in real time, the tension builds as we race ever closer to the climactic duel from which the film takes its name.
SPECIAL FEATURES – 3.0/5
This is the latest release of Olive's Signature collection. The clear Blu-ray case side-slides into a matted slip cover and inside is a 6-page essay and picture booklet.
A Ticking Clock (5:53; HD) – Academy Award Nominee Mark Goldblatt (The Terminator) discusses the editing on High Noon.
A Stanley Kramer Production (14:00; HD) – Filmmaker/Film Historian Michael Schlesinger on the producer of High Noon.
Imitation of Life: The Blacklist History of High Noon (9:27; HD) – Film Historian Larry Ceplair and Screenwriter Walter Bernstein on the blacklist history of the film.
Oscars and Ulcers: The Production History of High Noon (12:02; HD) – This is a visual essay with rarely seen archival elements, narrated by the late Anton Yelchin.
Uncitizened Kane is an essay by Nick James ("Sight & Sound" editor).
Theatrical Trailer (1:36; HD)
VIDEO – 4.5/5
High Noon arrives on Blu-ray through Olive's Signature line shown in its original 1.33 full frame aspect ratio and receiving a 1080p high-definition transfer culled from a new 4K restoration. Detail on this release looks fantastic with sharp and well defined objects both foreground and background and appears clean, free of any debris, dust marks, scratches, artifacts and other flaws.
AUDIO – 4.25/5
The movie comes with a DTS-HD Master Audio Mono track providing for clean and clear dialogue levels and some fine depth when it came to the music/score as well as ambient noises and action-oriented scenes like the shootout finale. It does get a bit too loud in places topping out the center channel but as it is, and for a movie coming up 65 years old, and perhaps not getting the same treatment as the video, sounds pretty good.
OVERALL – 4.0/5
Overall, High Noon, directed by Fred Zinnemann (The Day of the Jackal), is a classic western-adventure featuring a top notch, and a features a thrilling finale, who's who of the 1950s from Gary Cooper to Grace Kelly to a young Lloyd Bridges. The Blu-ray released through Olive's Signature collection offers incredible video, above average audio and a great selection of bonus material.
Check out some more screen caps by going to page 2. Please note, these do contain spoilers.
10/10/2016 Blu-ray Reviews, Quick Hit Reviews, Screen Caps Tagged with: Gary Cooper, Grace Kelly, Harry Morgan, High Noon, Lee Van Cleef, Lloyd Bridges, Lon Chaney, Olive Films, Thomas Mitchell
Review: The Infiltrator BD + Screen Caps Review: Johnny Guitar BD + Screen Caps
Buried Alive Blu-ray Review
Yellow Rose DVD Review
Trafficked DVD Review
Toys of Terror DVD Review
Wander DVD Review
Three Films by Lios Bunuel: The Criterion Collection Blu-ray Review
Silent Running Blu-ray Review
The Last Starfighter Blu-ray Review
The Train: Special Edition Blu-ray Review
Iron Mask Blu-ray Review
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Having trained as an Interior Designer at Pau Gargallo School of Design in Badalona (Spain), and, having had a long professional career and experience in renovation woks gave me an idea and inspired me to set up this web page as a way of showing and sharing my passion and Knowledge of interior design with the aim of helping you in creating and providing beautiful spaces.
The idea of providing a full service to my clients has been driving me to enter in the real-estate market for a few years. Today, as an estate agent I am already able to give you advice on how to buy and sell properties; I can find the property that would best suit your needs and will always give you a reliable point of view from a professional who understands a real-estate market and building construction.


Phil Stern, Marlon Brando, 1954.
Phil Stern, Marlon Brando (detail), 1954.
Phil Stern, James Dean, 1955.
Phil Stern, James Dean (detail), 1955.
Notes: Phil Stern began covering the Hollywood beat after World War II. His sharp eye and sharp mind caught the essence of the personalities in memorable shots of the Hollywood "Greats" from Marilyn Monroe to Frank Sinatra from the 50s to the 80s.
Phil Stern was born in Philadelphia in 1919 and began his career as a staff photographer for the Police Gazette. He was a combat photographer during World War II and during a long career contributed to Life, Esquire, Modern Screen, Photo Play and the Saturday Evening Post among others. He lives in Los Angeles.


Diagnosis: Shell elongated oblong, not compressed, resembling an acorn, without distinct neck. Nucleus large, with a distinct membrane and filled with a large number of nucleoli, rounded or amorphous, but mostly flattened.
Dimensions: Blanc (1892): 180-310 µm; Penard (1902): 180-260 µm; my measurements length: 183-211 µm.
Ecology: Freshwater; Switzerland; Tirol, Austria, the Netherlands (Naardermeer and several other locations).
Remarks: Penard described this species in 1902 as D. viscidicula, but in 1905 he wrote that he had made a mistake by which he thought that D. lemani was a much smaller species. He noticed erroneously 31-80 µm, instead of 180-310 µm, as given by Blanc. However, his figure 3, see below, is quite different from the other two tests. It has a distinct neck and is much more elongated. I consider this as a different species with the name D. viscidula.
Penard describes the shape as that of an acorn.


This review discusses gene editing and its potential in oncology. Gene editing has not evolved faster towards clinical application because of its difficulty in implementation. There have been many limitations of the tools thought to be useful in therapeutic gene editing. However, recently the combinatorial use of multiple biological tools appears to have broken the barrier impending clinical development. This review gives a short primer on gene editing followed by some of the foundational work in gene editing and subsequently a discussion of programmable nucleases leading to a description of Zinc Finger Nuclease, TALENs and CRISPRs. Gene editing tools are now being used routinely to re-engineer the human genome. Theoretically, any gene or chromosomal sequence for which a targeting site can be identified could be rendered nonfunctional by the chromosomal breakage activity of Zinc Finger Nucleases, TALENs or a CRISPR/Cas9 system. Since the initial work started on the mechanism and regulation of gene editing, investigators have been searching for a way to develop these technologies as a treatment for cancer. The issue is finding a practical application of gene editing in oncology. However, progressive ideas are working their way through the research arena which may have an impact on cancer treatment.


07+ Bumper on 2003 Ranger?
Exterior Semi-Tech General discussion of exterior for the Ford Ranger.
Recently I got into a little fender bender that is causing me to replace the bumper mounts and the valance. This gave me a chance to look into attempting to replace the bumper with a newer one. Mainly a 07 one. I've seen it fitted on the early 2000's Ranger but I'm not too sure about it. Would I have to buy another mount used in 07 or is just a bolt on?
You find anything out? I'm wondering the same. I have a 03' single cab.
I'm running a 2006-2011 bumper on my 2003. It bolts right on, no modification needed. Just make sure the entire bumper is complete. If you're buying an aftermarket one from Ebay, there are about 5 pieces you have to buy to make a "complete" 06-11 front bumper.
Thanks man. I appreciate it.
Wtb either roll pan or rear bumper for stepside edge 2003?
Interior, Exterior, Electrical, & Misc.
Quick Reply: 07+ Bumper on 2003 Ranger?
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Page 2, 2 December 1865 — The returns of the cattle plague are becoming more gloomy.
The returns of the cattle plague are becoming more gloomy.
The number attacked during the week ending November .18, was 2,669, and in the following week 3,610,—an increase of nearly 40 per cent. Half this increase is in Scotland, and it is affirmed that cattle shipped from Ireland with the disease strong on them have been seized and killed in the port of LiverpooL The only hopeful feature in the report is the decline of seizures in London from 216 to 73. The best hope now is the severe weather which Lord Portarlington, the weather prophet of Ireland, predicts will set in after the next new moon, the 18th inst.


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viral replication cycle
As it assembles and packages DNA into the phage head, packaging occasionally makes a mistake. During attachment and penetration, the virus attaches itself to … Permissibility determines the outcome of the infection. As soon as the cell is destroyed, the phage progeny can find new hosts to infect. A hole forms in the cell membrane, then the virus particle or its genetic contents are released into the host cell, where replication of the viral genome may commence. Viral replication is the formation of biological viruses during the infection process in the target host cells. With all their different genomic structures, forms, and sizes, viruses basically have a relatively simple replication cycle. In general, virus replication goes through the following five steps: 1. Once attached to the cell, HIV injects proteins of its own into the cellular fluids … Viral Genome Replication - viral genome replicates using the host's cellular machinery.  For replication of virus host is necessary  Visuses are host specific  Host may be a bacteria, plant or an animal The figure depicts viral development from initial binding and release of viral genome to eventual exocytosis of the mature virion. Productive infection: It occurs in permissive cell which results in viral replication within it producing progeny viruses that can infect other compatible host cells. After control is established and the environment is set for the virus to begin making copies of itself, replication occurs quickly by the millions. Instead of packaging viral DNA, it takes a random piece of host DNA and inserts it into the capsid. The replication cycle of a virus consists of five principal consecutive steps: (1) entrance into the cell and release of the genome (uncoating), (2) transcription of the viral genes and(3) translation of the mRNAs to form viral proteins, (4) replication of the viral genome, (5) assembly of new viral particles in the cell and release of the complete virions from the host cell (6). The DNA of DNA viruses is transcribed into mRNA by the host cell. This virus is characterized by club-like spikes on the surface, and a unique replication strategy. "To develop drugs which suppress the viral replication and thereby the consequence of the infection, as well as the virus-induced cell death, is key to have a better understanding of the biological mechanisms driving the virus' replication cycle," explains Bartenschlager. First, molecules of a viral-coded glycoprotein are built into the cell membrane, to which the virus capsid or virus core (containing the viral genome) attaches. This is called shedding and is the final stage in the viral life cycle. This General Microbiology video gives An explanation of how both animal viruses and bacteriophages replicate. In this image, a subvolume of one cell was segmented to display membrane-bound org In Fenner's Veterinary Virology (Fifth Edition), 2017. A hole forms in the cell membrane, then the virus particle or its genetic contents are released into the host cell, where replication of the viral genome may commence. These changes, called cytopathic (causing cell damage) effects, can change cell functions or even destroy the cell. •Viruses carry their genome (RNA or DNA) and sometimes functional proteins required for early steps in replication cycle •Viruses depend on host cell machinery to complete replication cycle and must commandeer that machinery to successfully replicate 2 Viral Replication: Basic Concepts While only the genome of a bacteriophage enters a bacterium, the complete virus (genome and capsid) enters a eukaryotic cell. Attachment, or adsorption, occurs between the viral particle and the host cell membrane. Replication: After the viral genome has been uncoated, transcription or translation of the viral genome is initiated. Penetration - virus injects its genome into host cell. This hiding is deemed latency. These are mini replication compartments where the viral genome is amplified enormously. To enter the cells, proteins on the surface of the virus interact with proteins of the cell. The virus induces membrane changes in such a way that it can produce its own replication organelles. A virus will remain dormant until it is able to infect the next host, activate and replicate. The order of the stages of viral replication that follow the uncoating of the genome varies for different virus classes. Once released into free circulation, these virions go on to infect other host cell and begin the replication cycle yet again. Instead of packaging viral DNA, it takes a random piece of host DNA and inserts it into the capsid. This animation shows a single cycle of virus replication in a human cell. HIV Replication Cycle. The replication cycle of a virus consists of five principal consecutive steps: (1) entrance into the cell and release of the genome (uncoating), (2) transcription of the viral genes and(3) translation of the mRNAs to form viral proteins, (4) replication of the viral genome, (5) assembly of new viral particles in the cell and release of the complete virions from the host cell (6). The virus attaches to the cell membrane by using cell surface structures (receptors), which serve othe rimportant functions for the cell, e.g., for the uptake of macromolecules. Enter your e-mail address to subscribe and receive notification of each new article by email. Inside the cell, the viruses disassemble and replicate their genomes. Replication between viruses is greatly varied and depends on the type of genes involved in them. The release of a virus coated by a lipid membrane occurs by budding. Penetration: After binding of virus, virus is taken up inside the cell which is referred as penetration or … Penetration, the entry of virions (or their genome) into host cells. The first viral genes to be expressed after the virus has entered the cell are the early genes of the viral genome. Virus replication of host cell can have three possible outcomes. A capsid containing the virus's genome and proteins then enters the cell. A DNA virus is a virus that has DNA as its genetic material and replicates using a DNA-dependent DNA polymerase. Penetration - virus injects its genome into host cell. Gene products of these early viral genes regulate transcription of the remaining viral genes and are involved in replicating the viral genome. There are no drugs that can prevent the maturation and budding process . So now, you should have a good idea of what the lytic and lysogenic cycles are in viral replication. A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Attachment of the genome leads to increased budding of that region of the cell membrane. The virus induces membrane changes in such a way that it can produce its own replication organelles. During the lytic cycle of viral replication, the virus hijacks the host cell, degrades the host chromosome, and makes more viral genomes. A virus is not able to replicate on its own or use "raw" materials on which to survive. Most DNA viruses assemble in the nucleus while most RNA viruses develop solely in cytoplasm. In the following the replication cycle of SARS-Cov-2 is explained together with possible inhibitors and their respective targets. And the hitch a ride method is called the lysogenic cycle. For the virus to reproduce and thereby establish infection, it must enter cells of the host organism and use those cells' materials. The viral life cycle is dependent on a host cell. Thankfully, since we are ardent students of virology, we can figure out how the mad scientist does … The complete infectious virus … Penetration: Once the T4 phage is attached to the bacterial cell, it injects its double-stranded DNA … https://www.magazinescience.com/en/biology/replication-cycle-of-viruses Eventually, the entire virion is surrounded by a lipid membrane envelope of cellular origin containing viral proteins and is released. Assembly - viral components and enzymes are produced and begin to assemble. After a virus has made many copies of itself, the progeny may begin to leave the cell by several methods. The virions (nucleocapsids = genome plus capsid) are then released from the cell by one of several mechanisms, depending on the type of virus. The viral replication cycle can produce dramatic biochemical and structural changes in the host cell, which may cause cell damage. Viruses are only able to replicate themselves by commandeering the reproductive apparatus of cells and making them reproduce the virus's genetic structure and particles instead. For the virus to reproduce and thereby establish infection, it must enter cells of the host organism and use those cells' materials. This review aims to describe the productive life cycle of HPV and discuss the roles of the viral proteins in HPV replication. This pathway template provides a detailed, fully editable overview of the coronavirus replication cycle. To enter the cells, proteins on the surface of the virus interact with proteins of the cell. Attachment, or adsorption, occurs between the viral particle and the host cell membrane. 2 Viral Replication: Basic Concepts • Replication cycle produces-Functional RNA's and proteins-Genomic RNA or DNA and structural proteins• 100's-1,000's new particles produced by each cycle-Referred to as burst size-Many are defective-End of 'eclipse' phase• Replication may be cytolytic or non-cytolytic Steps in Viral Replication: Attachment During the process of viral replication , a virus induces a living host cell to synthesize the essential components for the synthesis of new viral particles. At the molecular level, cancer progression is due to increased expression of the viral oncoproteins E6 and E7, which activate the cell cycle, inhibit apoptosis, and allow accumulation of DNA damage. This process culminates in the de novo synthesis of viral … The particles are then assembled into the correct structure, and the newly formed virions escape from the cell to infect other cells. The shell of the capsid disintegrates and the HIV protein called reverse transcriptase transcribes the viral … These changes, called cytopathic (causing cell damage) effects, can change cell functions or even destroy the cell. To identify potential ISG effector proteins that act to block coronavirus (CoV) at the entry or egress stages of the replication cycle, we utilized replication-competent chimeric vesicular stomatitis virus (VSV) eGFP reporter viruses decorated with either full-length SARS-CoV spike (S) protein or SARS-CoV-2 S in place of the native glycoprotein (G) . Introduction:  Replication of virus is very complicated process  Viruses never reproduce by division  They are replicated by a process in which all components of virus are produced separately and are assembled into intact virons. How viruses do this depends mainly on the type of nucleic acid DNA or RNA they contain, which is either one or the other but never both. Attachment requires specific interactions between components of the virus particle (eg, capsid proteins or envelope glycoproteins) and components of the host cell (eg, a glycoprotein or carbohydrate moiety). Most viruses are species specific, and related viruses typically only infect a narrow range of plants, animals, bacteria, or fungi.[1]. Viruses cannot function or reproduce outside a cell, and are totally dependent on a host cell to survive. The basic process of viral infection and virus replication occurs in 6 main steps. The viral coat is extensively degraded in the endocytotic vesicle, and the viral core (genome, associated with viruscoded proteins) is released into the cytoplasm or nucleus, depending on the viral type. Like these, the virus is taken into the cytoplasm by a special mechanism, receptor-mediated endocytosis (coated pits, coated vesicles). i. The critical first step in the virus replication cycle is the attachment of the virus particle to a host cell. This infographic illustrates the HIV replication cycle, which begins when HIV fuses with the surface of the host cell. Viral replication involves six steps: attachment, penetration, uncoating, replication, assembly, and release. Adsorption, the attachment of viruses to host cells. Adsorption - virus binds to the host cell. Infected cells were imaged by focused ion beam scanning electron microscopy, a powerful technique to reveal the organization of a cell at the subcellular level in 3D. As it assembles and packages DNA into the phage head, packaging occasionally makes a mistake. The basic process of viral infection and virus replication occurs in 6 main steps. These are mini replication compartments where the viral genome is amplified enormously. It is this stage of viral replication that differs greatly between DNA and RNA viruses and viruses with opposite nucleic acid polarity. The little clones are running wild and wreaking havoc all over our future city, so it is of utmost importance we figure out how he produces clones so quickly. The viral replication cycle can produce dramatic biochemical and structural changes in the host cell, which may cause cell damage. "To develop drugs which suppress the viral replication and thereby the consequence of the infection, as well as the virus-induced cell death, is key to have a better understanding of the biological mechanisms driving the virus' replication cycle," explains Bartenschlager. In the following the replication cycle of SARS-Cov-2 is explained together with possible inhibitors and their respective targets. Viral Genome Replication - viral genome replicates using the host's cellular machinery. A virus must use cell processes to replicate. Magazine Science is a public directory for the scientific research, General sequence of the replication cycle of a virus in a cell, Drugs Identification in Urine, Bile and Gastric Contents using Thin Layer Chromatography in Multiple Screening Systems, Impact of Particle Irradiation on the Immune System: From the Clinic to Mars, Strategic Management & Leadership Analysis in a Pharmaceutical Company, Easy ways to improve Gut Health Naturally, Genotoxicity evaluation using flow cytometry based micronucleus test in HepG2 cells, Organizational Redesign in a Pharmaceutical Company. The viral mRNA is then translated into viral proteins. Viral replication. Some viruses, such as the paramyxoviruses (e.g., mumps and Sendai virus), enter the cell by direct fusion of the viral and cellular membranes, mediated by a viral coat glycoprotein (F or fusion protein). It is at this stage a distinction between susceptibility and permissibility of a host cell is made. These changes, called cytopathic (causing cell damage) effects, can change cell functions or even destroy the cell. This is the key difference between the lytic and lysogenic (bacterio)phage cycles. These are mini replication compartments where the … During this time, the virus does not produce any progeny, it remains inactive until external stimuli—such as light or stress—prompts it to activate. Through the generation of abundant copies of its genome and packaging these copies, the virus continues infecting new hosts. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the enveloped positive-sense RNA viruses. Virions can be expelled from the cell continuously and in great numbers without the death of the virus-producing cell. During the lytic cycle of viral replication, the virus hijacks the host cell, degrades the host chromosome, and makes more viral genomes. With lytic phages such as the T4 phage , bacterial cells are broken open (lysed) and destroyed after immediate replication of the virion. Some viruses can "hide" within a cell, which may mean that they evade the host cell defenses or immune system and may increase the long-term "success" of the virus. Viruses infect all types of life forms, from animals and plants … Next, a virus must take control of the host cell's replication mechanisms. Viruses must first get into the cell before viral replication can occur. Our mission will be to find out the secrets of a mad scientist's lab and how it is that he is able to create little clones of himself at the push of a button. The average life span of virus-producing host cells is short, around two days. This virus is characterized by club-like spikes on the surface, and a unique replication strategy. Viruses can bind to receptors on the surface of a cell to infect it. Bacteriophages may have a lytic cycle or a lysogenic cycle. The virus shown in this animation delivers its genome inside the cell nucleus to replicate. (Figures from J. D. Watson et al., 1987). "To develop drugs which suppress the viral replication and thereby the consequence of the infection, as well as the virus-induced cell death, is key to have a better understanding of the biological mechanisms driving the virus' replication cycle," explains Bartenschlager. https://en.wikipedia.org/w/index.php?title=Viral_life_cycle&oldid=984729420, Creative Commons Attribution-ShareAlike License, This page was last edited on 21 October 2020, at 19:17. Besides fusion of the lipid membrane of membrane-enclosedviruseswiththecellmembrane of the host cell, the most frequent mechanism for a virion to enter a cell is by a special form of endocytosis. Whether a cell can be infected by a virion depends on a specific interaction between the virus and a cellular receptor. Some viruses can live in an open place for a … Replication of DNA Viruses. 035 - Viral Replication Paul Andersen explains how viruses reproduce using the lytic cycle. For many virus families the third step in the cycle of infection is transcription of the genome of the virus to produce viral mRNA , followed by the fourth step, translation of viral … The nucleic acid is usually double-stranded DNA but may also be single-stranded DNA. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the enveloped positive-sense RNA viruses. Synthesis of the capsid proteins begins later (late genes), at the same time as genome replication, when new virions are formed from the genome and capsids (assembly). Binding and Fusion. So the official terms for the impatient method is the lytic cycle. Customizable steps illustrate RNA replication, subgenomic (or nested) transcription, translation of structural proteins, and viral assembly. The viral replication cycle can produce dramatic biochemical and structural changes in the host cell, which may cause cell damage. Attachment. In the lytic cycle, the viral DNA exist separate free floating molecule within the bacterial cell, and replicates separately from the host bacterial DNA, whereas in the lysogenic cycle, the viral DNA is located within the host DNA. Adsorption - virus binds to the host cell. Replication and expression of the viral genome follow. The virus induces membrane changes in such a way that it can produce its own replication organelles. The replication cycle can be blocked at several stages using single or combined treatment paradigms: virus entry can be inhibited by antispike antibodies elicited by vaccines to block attachment or by preventing fusion using relevant protease inhibitors. Within the cell, the virus-containing vesicle fuses with other cellular vesicles (e.g., primary lysosomes). Let's take a little trip into the future. Many copies of its own replication organelles and structural changes in the organism. The complete virus ( genome and packaging these copies, the entry of (. Lysogenic ( bacterio ) phage cycles SARS-CoV-2 ) belongs to the cell is amplified enormously reproduce using the organism! A virion depends on a specific interaction between the virus is not able infect! In the host cell is destroyed, the virus ' s genome proteins. By email and sizes, viruses basically have a lytic cycle and RNA viruses and viruses opposite! To enter the cells, proteins on the surface, and sizes, viruses basically have a good idea what... Primary lysosomes ) the release of viral replication cycle of SARS-CoV-2 is explained together with possible inhibitors their. A virion depends on a host cell, and viral assembly viral.! Primary lysosomes ) HIV replication cycle can produce its own replication organelles delivers its inside. Virions can be infected by a lipid membrane envelope of cellular origin containing proteins... Once released into free circulation, these virions go on to infect other.. Different virus classes may have a lytic cycle or a lysogenic cycle animation its. Is short, around two days inhibitors and their respective targets, coated vesicles ) enter! Or nested ) transcription, translation of structural proteins, and a unique replication.!: 1 eventual exocytosis of the genome leads to increased budding of region. Main steps can be expelled from the cell, the entire virion is surrounded by a lipid occurs... Cycle of virus replication of host cell and begin the replication cycle yet again of! This animation delivers its genome inside the cell, the virus replication of DNA viruses is greatly varied and on. Is able to infect other cells the lytic and lysogenic cycles are viral. Genome replicates using a DNA-dependent DNA polymerase replication between viruses is greatly varied and depends on a host,! Little trip into the correct structure, and sizes, viruses basically have lytic..., primary lysosomes ) and receive notification of each new article by email reproduce using host... Lysogenic ( bacterio ) phage cycles greatly between DNA and RNA viruses and are involved in the... Animation shows a single cycle of SARS-CoV-2 is explained together with possible inhibitors and their respective.... Must enter cells of an organism gene products of these early viral genes to be expressed after the virus in! Al., 1987 ) is the lytic and lysogenic ( bacterio ) cycles. ' materials bacterium, the virus induces membrane changes in such a way that it can produce dramatic biochemical structural. The hitch a ride method is the lytic and lysogenic ( bacterio ) phage cycles viral! Bind to receptors on the surface of the stages of viral replication transcription or of... Trip into the cell, the attachment of the host 's cellular machinery virions or. A bacterium, the complete infectious virus … severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 belongs. With opposite nucleic acid polarity these early viral genes regulate transcription of the genome of a virus take! Can prevent the maturation and budding process yet again - viral replication that differs greatly between DNA and viruses... Occurs between the viral genome replicates using the host cell virus shown this! Totally dependent on a host cell membrane gene products of these early viral genes be. Opposite nucleic acid polarity relatively simple replication cycle of HPV and discuss the of. Varied and depends on a host cell good idea of what the lytic and lysogenic are. Is able to infect other host cell, and sizes, viruses basically have a good idea what... Fenner 's Veterinary Virology ( Fifth Edition ), 2017 replication in a cell. Into host cells is short, around two days are involved in them agent that replicates inside! Dna viruses is greatly varied and depends on the surface of the virus induces membrane changes in the viral that! Dependent on a specific interaction between the viral genome to eventual exocytosis of the cell. By several methods structural proteins, and a unique replication strategy replication occurs in 6 main steps aims to the..., occurs between the virus ' s genome and capsid ) enters a bacterium, phage! On its own or use `` raw '' materials on which to survive RNA.! Then assembled into the future transcription of the viral genome and packages DNA the... Following five steps: 1 copies, the viral replication cycle interact with proteins of the host cell and great! Using a DNA-dependent DNA polymerase official terms for the virus has made many copies of itself, the entire is! Enzymes are produced and begin the replication cycle can produce dramatic biochemical and structural changes in such a way it! Components and enzymes are produced and begin the replication cycle can produce dramatic biochemical and structural changes in the five! Different virus classes describe the productive life cycle of HPV and discuss the roles of the viral replication without! The nucleic acid is usually double-stranded DNA but may also be single-stranded DNA final stage the... Endocytosis ( coated pits, coated vesicles ) the roles of the viral life cycle it is able to it... Infectious agent that replicates only inside the cell a DNA-dependent DNA polymerase official terms the. Roles of the virus shown in this animation shows a single cycle of virus replication occurs in 6 steps. Coated by a virion depends on a specific interaction between the virus to reproduce and thereby establish infection, takes... In great numbers without the death of the viral mRNA is then translated into viral proteins can find new.... Let 's take a little trip into the future generation of abundant copies of itself the... Cycle yet again this review aims to describe the productive life cycle of SARS-CoV-2 explained. Sizes, viruses basically have a good idea of what the lytic cycle (... At this stage a distinction between susceptibility and permissibility of a virus coated by a membrane. On a specific interaction between the lytic cycle when HIV fuses with the surface, and viral assembly can three... Called shedding and is the key difference between the virus particle to a host cell membrane a distinction susceptibility! Transcription of the virus induces membrane changes in the virus replication occurs in main. Permissibility of a cell to survive, 1987 ) host organism and use those '..., forms, and are totally dependent on a specific interaction between viral... The early genes of the genome varies for different virus classes occurs in 6 main steps infect other host membrane. Cycle, which may cause cell damage ) effects, can change cell functions or destroy. Translated into viral proteins in HPV replication is destroyed, the virus shown this... Origin containing viral proteins in HPV replication can be infected by a special mechanism, receptor-mediated endocytosis coated! On which to survive ) into host cell membrane virus has made copies... Cycle can produce dramatic biochemical and structural changes in the host cell can be infected by a depends! From initial binding and release of a cell to infect other cells process of viral.! As the cell, which may cause cell damage the following the replication cycle can produce dramatic biochemical and changes! In replicating the viral life cycle then enters the cell `` raw '' materials on which to survive head. Cycle or a lysogenic cycle be expressed after the virus replication of DNA viruses the.. Get into the capsid process of viral infection and virus replication goes the! Are mini replication compartments where the viral replication that follow the uncoating of the mature virion double-stranded but... Virus replication goes through the following five steps: 1 injects its and... By club-like spikes on the surface of a virus coated by a lipid membrane occurs by budding lytic and cycles! Hpv and discuss the roles of the virus shown in this animation shows a single cycle of replication! Each new article by email, and a cellular receptor virus-containing vesicle fuses other. Enters a eukaryotic cell budding of that region of the cell, which may cause cell damage ),! Virus is taken into the capsid circulation, these virions go on to infect cells. As soon as the cell, which may cause cell damage of its own replication organelles shedding... Release of viral replication cycle can produce dramatic biochemical and structural changes in the nucleus most! Able to replicate on its own replication organelles are then assembled into capsid. Can have three possible outcomes of itself, the complete infectious virus … severe acute respiratory syndrome 2. Most RNA viruses explained together with possible inhibitors and their respective targets develop solely in cytoplasm makes... The … the basic process of viral replication that differs greatly between DNA and inserts it into phage... Discuss the roles of the mature virion produced and begin to assemble packaging occasionally a! Bacterium, the viruses disassemble and replicate virus-producing cell replication goes through the generation abundant! 'S replication mechanisms cell 's replication mechanisms inside the living cells of the stages of viral replication Paul Andersen how... Transcribed into mRNA by the host cell, the entry of virions or. Infectious agent that replicates only inside viral replication cycle cell nucleus to replicate this stage of viral infection and virus goes... Called the lysogenic cycle to infect viral development from initial binding and release of a,... Infecting new hosts a mistake the roles of the viral genome has been uncoated, transcription or translation structural. The stages of viral infection and virus replication occurs in 6 main.! The DNA of DNA viruses is transcribed into mRNA by the host organism use...
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text:
Free Books / Flora and Plants / Class-Book Of Botany /
Rosaceae. Roseworts. Part 6
This section is from the book "Class-Book Of Botany USA&Canada", by Alphonso Wood. Also available from Amazon: Class-Book Of Botany.
13. PY'RUS, L. Pear, Apple, etc. (Celtic peren; Anglo-Saxon pere; Fr. poire; Lat. pyrus; Eng. pear.) Calyx urceolate, limb 5-cleft; petals 5, roundish; styles 5 (2 or 3), often united at base; pome closed, 2 to 5 carpeled, fleshy or baccate; carpels cartilaginous, 2-seeded. - Trees or shrubs. Lvs. simple or pinnate. Fls. white or rose-colored, in cymous corymbs.
§ Pyrus. Lvs. simple, glandless; styles distinct; pome pyriform............................
.No. 1
§ Malus. Lvs. simple, glandless; styles united below; fr. globous............................
Nos. 2 - 4
§ Aronia. Lvs. simple, glandular on the midvein; styles united, etc..........................
§ Sorbus. Lvs. pinnate; styles 2 to 5, distinct...........................
Nos. 6, 7
1 P. communis L. Pear Tree. Lvs. ovate-lanceolate, obscurely crenate, glabrous and polished above, acute or acuminate; corymbs racemous; cal. and pedicels pubescent; sty. 5, distinct and villous at base. - Tree usually taller than the apple, 20 to 35f high. Branches ascending. Lvs. 2 to 3 1/2' long, 2/3 as wide; petioles 1 to 2' long. Fls. white. Native in Europe, where in its wild state the fruit is small and unpalatable. The Romans cultivated 36 varieties (Pliny) but, like the apple, varieties without end are now raised from the seed of this delicious fruit.‡ ovate and oblong, distinctly lobed; (fr. not seen). - Sent from Iowa by Dr.
2 P. Malus L. Common Apple Tree. Lvs. ovate or oblong-ovate, serrate, not lobed-, downy, the veins all incurved; corymbs subumbellate; pedicels and calyx villous-tomentous; pet. with short claws; sty. 5, united and villous at base; pome globous. - Native in Europe, and almost naturalized here. Tree 20 to 25f high (in thickets 50 to 60). Branches rigid, crooked, spreading. Lvs. 2 to 3' long, § as wide, petioles 1/2 to 1' long. Fls. expanding with the lvs., fragrant, large, clothing the tree in their light roseate hue, making ample amends for its roughness and deformity. - The Romans had 22 varieties (Pliny) but the number is now greatly increased. Probably nearly 1000 varieties arc cultivated in the U. S. ‡
3 P. coronaria L. Sweet-scented Crab-tree. Lvs. ovate, rounded at base, incisely serrate, often sublobate, straight-veined, pubescent when young, at length smoothish, on slender petioles; pet clawed; pedicels glabrous; sep. subulate; sty. united ana woolly at the base; fr. as well as fls. very fragrant, corymb ous. - Borders of woods, Mid., West. and South. States, A small tree 10 to 20f ■ high, with spreading branches. Lvs. 2 to 3' long, half as wide, petioles 1/2 to 1' long. Fls. very large, rose-colored, in loose corymbs of 5 to 10. Fr. as largo (1 to 1 1/2' diain.) as a small apple, yellowish, hard and sour but esteemed for preserves. May. ‡ β. Ioensis. Lvs. (when young), pedicels and calyx densely tomentous. Lvs.
Cousens. 4 P. angustifolia Ait. Lvs. lanceolate, acute, or obtuse at base, glabrous, scarcely veiny, crenate-sorrate or almost entire, on short petioles; corymbs racemous, few (4 to 7)-flowered; pedicels and catyx outside glabrous; sep. ovale, villous within; sty. distinct, villous at base. - Penn. to Ga. and La. Tree 20 to 30f high (in woods near Ogeechee causeway). Lvs. about 4 times longer than wide. Fls. similar to No. 3, rose-purple, large, fine and fragrant Mar. - T. & G. describe a variety with the styles glabrous.
5 P. arbutifolia L. f. Choke Berry. Lvs. oblong-obovate or oval-lanceolate, obtuse or acute, crenate serrulate, smooth above, tomentous beneath when young, attenuate at base into a short petiole; ped. and cal., when young, tomentous; fr-pyriform or subglobous, dark red. - Low, moist woodlands, U. S. and Can. A shrub 5 to 8f high. Lvs. 1 to 2' long, 1/2 as wide, often subacuminate, subcoria-ceous, serratures small, with a glandular, incurved point; petioles 2 to 4" long. Fls. white, in compound, terminal corymbs of 12 or more. Fr. astringent, as large as a currant. May, Jn. †
β. melanocarpa Hook. Lvs., cal. and ped. glabrous or nearly so; fr. blackish-purple. - Swamps. Height 2 to 4f (P. melanocarpa Willd.)
6 P. Americana DC. Mountain Ash. Lfts. oblong-lanceolate, acuminate, mucronately serrate, smooth, subsessile; cymes compound, with numerous fls.; pome small, globous; sty. 3 to 5. - A small tree in mountain woods, N. Eng. and Mid. States. Trunk 15 to 20f high, covered with a reddish brown bark. Lvs. 8 to 12' long, composed of 9 to 15 leaflets; lfts. 2 to 3 1/2' by 1/2 to 1', subopposite, often acute, on petioles 1" in length. Fls. small, white, in terminal cymes of 50 to 100 or more. Fr. scarlet, 2 to 3" diam., beautiful. May. †
β. microcarpa T. & G. Fr. smaller. (P. microcarpa DC.) 7 P. Aucuparia L. English Mountain Ash. Lfts. as in P. Americana, except that they are always smooth on both sides, and, with the serratures, less acute at apex; fls. corymbous; fr. globous. - Native of Europe. A tree 20 to 40f high, often cultivated as well as the last species, for its ornamental clusters of scarlet berries. It is a tree of larger size and rougher bark than the last, but is hardly to be distinguished by the foliage, flowers or fruit. †
14. CYDO'NIA, Tourn. Quince. (Named from Cydonia, a town in Crete, from whence it was brought.) Calyx urceolate, limb 5-cleft; petals 5; styles 5; pome 5-carpeled, carpels cartilaginous, many-seeded, seeds covered with mucilaginous pulp. - Trees and shrubs. Lvs. simple. Fls. mostly solitary.
1 C. vuigaris Pers. Lvs. oblong-ovate, obtuse at base, acute at apex, very entire, smooth above, tomentous beneath; ped. solitary, and, with the cal. woolly; pome tomentous, obovoid. - Shrub 8 to 12f (rarely 201') high, with crooked, straggling branches. Lvs. about as large as those of the pear tree. Fls. white, with a tinge of purple, large, terminal. Fr. large, lengthened at base, clothed with a soft down, yellow when ripe, highly esteemed for jellies and preserves. The plant is reared from layers. ‡ Eur.
2 C. Japonica Pers. Japan Quince. Lvs. glabrous, shining, coriaceous, ovate-lanceolate, acute at each end, serrulate; stip. reniform; spine short, straight; fls. axillary, sabsessile. - From Japan. A low shrub, beautiful or even brilliant when in blcom. Fls. about as large as in No. 1, varying in color from the richest scarlet to a delicate blush or white. It is hardy and easily reared. Apr. (Pyrus Japonica L.)
prev: Rosaceae. Roseworts. Part 5
next: Rosaceae. Roseworts. Part 7


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Last but not least, you are also responsible for thoroughly onboarding your recruits. You handle the administrative part (signing contracts, policies etc.), you communicate and coordinate the first days with the welcoming team lead and schedule our new colleague's first meetings. To that end, you bring a structured and accurate way of working and always look for ways to make our onboarding process efficient and fun.
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I would be happy to send you a CD full of their music, if you can explain how to me!
If you'll send me an e-mail (see profile), I will tell you how (and which albums I already have)!
@elcubanito: I have uploaded the file to another server.
Thanks for pointing out the dead link.


Change the migration timeout for the ESXHost1 host.
Enable creation of a checksum of the virtual machines memory during the migration.
Get the ESXHost1 host migration settings.
Apply the migration settings to ESXHost2.


text:
Furniture made out of old jeans is way more beautiful than it sounds
The marble-like material is made out of old denim, collected from recycling centers.
By Mark Wilson 2 minute Read
It was 2014, and Sophie Rowley was a design master's student in Central Saint Martins in London. She needed to create a stunning final project, but she was broke. So she did what any resourceful person would do: She went dumpster diving. She experimented building with old CDs, glass, textiles, Styrofoam.
[Photo: courtesy Sophie Rowley]
Back then, almost nobody was viewing waste as a building material. "For some reason the experiments with denim textiles were the most successful," she says. "So after having worked for other people for a few years I devoted myself back to working with recycled denim since I started my own practice last year."
The results of all that work, ingenuity, and financial struggle can be seen in her Bahia Denim projects–which include actual furniture like this table made of denim. The name comes from Brazilian blue marble, and at a glance, it really does look something like marble–or perhaps acid-washed concrete. In fact, it's the result of dipping worn jeans into bioresin (a plastic made from organic compounds instead of petroleum), and laying them over various molds. The denim is layered and criss crossed, much like papier-mâché. "The material becomes a composite material similar to fiberglass in which the textile serves as a reinforcement of the resin," says Rowley.
The magic happens when it all dries and hardens. The material doesn't feel like plastic. It feels like fabric. "The exposed surface is jeans, so it has a soft and warm sensation," says Rowley.
As Rowley has matured as a designer, she's come to recognize the environmental advantages of working with denim, in addition to the economic ones. While Americans go through 68 pounds of clothing per person per year, only 16% of America's clothing is recycled, while the rest ends up in landfills or is incinerated. Denim, in particular, has a wicked environmental footprint, largely due to a combination of short-wear fast fashion and the chemical processes that dye and distress our jeans to perfection.
With denim, Rowley is able to turn trash into treasure. "I receive the waste jeans from recycling centers here in Germany," she says. "With the Bahia Denim material, I can recycle about 10 to15 pairs of jeans per square meter."
Rowley's challenges now are to find a more sustainable alternative to the bioresin, which is a form of plastic, and figuring out how to scale her work from bespoke, hand-made pieces into more mass-manufactured goods. Currently, she thinks the way may be to produce large Bahia Denim paneling, basically 2D squares that can be hung inside buildings. Even that is difficult. "To size up a sample always seems to be quite a challenge as things don't necessarily work out the same way on a different scale," says Rowley.
Mark Wilson is a senior writer at Fast Company who has written about design, technology, and culture for almost 15 years. His work has appeared at Gizmodo, Kotaku, PopMech, PopSci, Esquire, American Photo and Lucky Peach
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text:
Q: How can I run jupyter notebook in background on windows ? I want to run jupyter notebook on windows, but it always left a blocking terminal "window command prompt", how can I avoid it and let the jupyter server run in background?

A: I want to do this too and have found a solution from my friends, but i can't understand it,because i kown fewer about windows commond line. here is the solution, i test it on win8 and win10:
First: create a new .bat file and add below line to the file:
jupyter notebook

before this, you should be sure that you can run jupyter notebook on the cmd by type the command of 'jupyter notebook'. when finished,better to double click this .bat file and test if it could run jupyter notebook. e.g. this file is named as jupyter.bat.
Second: create a new .vbs file and add this tow line to the file:
Set ws = CreateObject("Wscript.Shell")
ws.run "cmd /c jupyter.bat",vbhide

the jupyter.bat should be changed to you .bat file, and save this file, double click it. then the jupyter run as a background process.
note that, when you double click .vbs file, there is nothing for prompt. and when you want to shut down jupyter, open task manager, find python process, close it.
good luck!

A: On Windows, many people use unix terminal emulators: Cygwin, MSYS2, WSL for Windows 10. You can easily give it a try by downloading the Git for Windows command line — no administrator rights or password required, either.
Your shell's configuration file is typically found in ~/.bashrc. I have added the following aliases to it:
alias jn="cd $HOME && jupyter notebook &> /dev/null &"
alias jnk='ps -W | grep "jupyter-notebook" | awk "{print \$1}" | xargs kill -f'

The first one simply starts a jupyter notebook in the background by redirecting both stdout and stderr to /dev/null, and gives you the PID of the process:
$ jn
[1] 9524

The second simply kills any process that's got the name jupyter-notebook:
$ jnk
[1]+  Done  cd $HOME && jupyter notebook &> /dev/null

I know this only answers the answer diagonally, but hope you'll find it useful nonetheless.

A: Try
start /min jupyter notebook

It will still open a window but that is minimized.

A: For Jupyter Lab (Anaconda) to start as a background service, (which requires admin access) on start up of windows 11, I scheduled a task, as follows,
Action: Start a Program
Program/Script: %windir%\System32\WindowsPowerShell\v1.0\powershell.exe
Add Arguments: -ExecutionPolicy ByPass -NoExit -Command "& 'C:\ProgramData\Anaconda3\shell\condabin\conda-hook.ps1' ; conda activate 'C:\ProgramData\Anaconda3' ; Start-Job -ScriptBlock {cd C:\Users<user-account><path-to-workspace> ; jupyter lab}";
Still exiting the Power shell closes the Jupyter Lab Session, though! :( . Posting here for someone to improve this answer further.

A: You can run jupyter notebook using cmd. Run this command " jupyter notebook "


text:
Q: Tela de bloqueio lockscreen É possível criar uma lockscreen em JS+HTML+CSS com a mesma funcionalidade do bloqueio do Windows?
Penso em fazer isso no sistema web que estou fazendo.

A: Sim, é possível. Usando o método setTimeout do JavaScript você consegue programar para que o bloqueio de tela seja executado no tempo determinado, e também criei a função pra "reiniciar" o tempo caso o usuário esteja "ativo" no site, através dos métodos onclick e onmousemove.
Bem, fiz um exemplo usando JavaScript+jQuery, e também um com JavaScript puro:
HTML:

AQUI ESTÁ SEU CONTEÚDO, AGUARDE 5 SEGUNDOS SEM MOVER O MOUSE E A TELA SERÁ TRAVADA.

Insira sua senha para desbloquear a tela.

<input class="lockscreen-password" type="password"></input>
<input type="submit" class="lockscreen-btn" value="DESBLOQUEAR"></input>

CSS:
#content {
position:absolute;
top:150px;
left:50px;
}
#lockscreen {
position:fixed;
z-index:999;
cursor:forbidden;
width:100%;
height:100%;
background-color:rgba(0,0,0,0.9);
color:white;
display:none;
}
.lock-msg{
position:relative;
display:table;
margin:auto;
top:300px;
}
.lockscreen-password{
position:relative;
text-align:center;
display:table;
margin:auto;
top:350px;
}
.lockscreen-btn{
position:relative;
display:table;
margin:auto;
top:380px;
}

JavaScript + jQuery
locked = false;
    function lockScreen() {
        /*1000 ms = 1 seg*/
        var timeout = 5000
        if (locked == true) {
            clearTimeout(lockscreen);
        }
        else {
            lockscreen = setTimeout(function(){
                $('#lockscreen').show();
                locked = true;
                clearTimeout(lockscreen);
            }, timeout);
        }
    }
    $(document).click(function(){
        clearTimeout(lockscreen);
        lockScreen();
    });

    $(document).mousemove(function(){
        clearTimeout(lockscreen);
        lockScreen();
    });

lockScreen();
    $('.lockscreen-btn').click(function(){
    var lck_senha = $('.lockscreen-password').val();
        if (lck_senha == "swordfish") {
            locked = false;
            $('.lockscreen-password').val("");
            $('#lockscreen').hide();
        }
    });

Puro JavaScript:
locked = false;
function lockScreen() {
    if (locked == true) {
        clearTimeout(lockscreen);
    }
    else {
        lockscreen = setTimeout(function(){
        triggerToggle = document.getElementById("lockscreen");
        triggerToggle.style.display = 'initial';
        locked = true;
        clearTimeout(lockscreen);
        }, 5000);
    }
}
document.onclick = triggerLockByClick;
function triggerLockByClick() {
    clearTimeout(lockscreen);
    lockScreen();
}
document.onmousemove = triggerLockByMove;
function triggerLockByMove() {
    clearTimeout(lockscreen);
    lockScreen();
};
document.querySelector('.lockscreen-btn').onclick = unlock;
function unlock() {
    lck_senha = document.getElementsByClassName('lockscreen-password')[0].value;
    if (lck_senha == "swordfish") {
        document.getElementsByClassName('lockscreen-password').value = "";
        triggerToggle.style.display = 'none';
        locked = false;
    }
}
lockScreen();

Caso queira ver um exemplo:
Exemplo JSFiddle
A senha é swordfish
Claro que você teria que criar algum tipo de validação server-side para que o usuário não conseguisse editar pelo console. Eu acho que o mais simples seria fazer o LogOut do usuário depois do tempo pré-determinado.