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IPC International Fellowship Program
FOSTERING THE NEXT GENERATION OF PSORIASIS LEADERS
IPC's International Fellowship program provides young dermatologists and researchers interested in psoriasis full access to the knowledge of our network of experts and represents our commitment to cultivating expertise in the field.
Awarded fellows are matched with IPC Board Members or Councilors to observe and participate in clinical practice and laboratory research of patients with psoriasis. This opportunity provides real-world practice in the investigation, diagnosis, and development of treatment plans for psoriasis. In addition, the program provides an opportunity for IPC Fellows to develop ongoing relationships with key opinion leaders by participating in IPC programs and activities throughout a one-year period.
Encourage and educate early-career dermatologists to treat psoriasis as a systemic disease with significant comorbidities
Expose early-career dermatologists to key opinion leaders and encourage their participation in projects and dialogue that furthers the advancement of psoriasis research and treatment globally
Connect and strengthen early-career commitment to the field of psoriasis research and treatment
ADDITIONAL INFORMATION AND HOW TO APPLY
Meet the 2019 IPC International Fellows
Our 2019 Fellows will be active participants in IPC programs with the world's key opinion leaders, gaining exposure to clinical, research and educational skills that will further their careers as psoriasis leaders. Chosen from a highly qualified international field of young dermatologists, IPC's 2019 International Fellows represent the future of psoriasis leadership and the organization's commitment to growing expertise in the field.
Romina Contreras, MD, ParaguayDr. Contreras is a specialist in dermatology and venereology. She holds clinic and teaches at the Hospital de Clínicas Department of Dermatology in Asunción, Paraguay. She has special interest in the integral management of psoriasis, combining clinical practice and research. She is the principal investigator for "VDR polymorphism and its relationship with psoriasis severity". Dr. Contreras will be placed with Prof. Catherine Smith at the St. John's Institute of Dermatology, in London, United Kingdom and will attend the World Congress of Dermatology.
Deepak M.W. Balak, MD, PhD, MSc, Netherlands
Dr. Balak works as a dermatologist at the Department of Dermatology and Allergology of the University Medical Center Utrecht in Utrecht, the Netherlands, where he combines patient care with teaching responsibilities and research. His clinical interests are centered on the impact and management of inflammatory and autoimmune diseases. His scientific interests include translational medicine, clinical drug development, and evaluation in the field of chronic immune-mediated inflammatory skin diseases, such as psoriasis. As a 2019 Fellow, he will study with Dr. Alice Gottlieb at the Mount Sinai Hospital in New York, New York and attend the European Academy of Dermatology and Venereology Congress.
REBECCA NGUYEN, MB BS, FACD, AUSTRALIA
Dr. Nguyen is a consultant dermatologist at the Skin and Cancer Foundation, Monash Health and Eastern Health. She completed her dermatology training in 2016 and has published as lead author on eight peer reviewed manuscripts and presented at various local and international forums. She holds a special interest in the management of complex biologic patients and clinical trials in emerging treatments for psoriasis. Dr. Nguyen will be placed with Prof. Carle Paul at the Department of Dermatology at Paul Sabatier University in Toulouse, France and will attend the World Congress of Dermatology.
MARIJANA VIČIĆ, MD, CROATIADr. Vičić is a resident of dermatovenereology at the Clinical Hospital Center of Rijeka, Croatia and a research fellow and assistant lecturer at the University of Rijeka School of Medicine, Department of Dermatovenereology. Dr. Vičić is currently working toward a PhD in Biomedicine; as part of her doctoral thesis she is investigating cytotoxic mechanisms in the pathogenesis of psoriasis and lichen planus. Dr. Vičić will be placed with Prof. Diamant Thaçi at the Comprehensive Center for Inflammation Medicine, University of Lübeck in Germany and will attend the World Congress of Dermatology.
The 2019 IPC International Fellowship Program is supported by AbbVie and Janssen Biotech, Inc.
PAST OUTCOMES
Meet the 2018 Fellows
Claudia de la Cruz, MD
Clinica Dermacross
IPC Board Member
Claudia De la Cruz, MD, is a dermatologist in Santiago, Chile. She earned her d egree at Universidad De Chile and was an Assistant Professor at Pontificia Universidad Católica de Chile between 2005 and 2013. Dr. de la Cruz is the Founder and Director of Clínica Dermacross since 2010 in Santiago. She has served on the Board of Directors of the International Psoriasis Council since 2017 and is a regional coordinator for Latin America for the Global Psoriasis Atlas project. Her focus has been in working for psoriasis in her country through the Chilean Society of Dermatology, at the beginning of her career, and then for Latin America, where she has lead the IPC Latin American working group together with Ricardo Romiti from Brazil. In her role as regional coordinator for Latin America for the Global Psoriasis Atlas, she has focused on collecting information on the incidence of psoriasis in Latin America, helping to build a net of experts through the region. She has helped raise awareness and improve access to treatment in the region, evaluating the different barriers to access in Latin America and other underserved areas in the world. She has also worked in education at the IPC, first on the International Fellowship program, that helps train new leaders in the psoriasis field, and currently as chair of the Masterclass Steering Committee.
Elise Kleyn, MBChB, FRCP (UK), MMedSci, PhD
University of Manchester; Salford Royal NHS Foundation Trust
Manchester, England, United Kingdom
Dr. Elise Kleyn is a Clinical Senior Lecturer and Consultant Dermatologist. She pursued her postgraduate training on the North West Regional Dermatology Training Scheme. She was awarded her PhD degree from The University of Manchester and her MMedSci degree from The University of Liverpool. Dr. Kleyn is the Director of the Brain-Skin Unit, Centre for Dermatology Research and one of five Consultant dermatologists who lead the Greater Manchester Psoriasis Service. Dr. Kleyn's research has been focused on the 'brain-skin' axis in health and disease, forming the basis of her PhD thesis, and for which she has received a number of national awards. In addition, she has a particular interest in psoriasis, brain imaging as well as the safety of biological therapies and their use in psoriasis. She has been an invited speaker at numerous national and international meetings and is a member of the International Psoriasis Council as well as the BADBIR Data Analysis Working Group. She is actively involved in medical education both in the clinical setting and as a PhD supervisor and runs the successful Manchester Psoriasis Preceptorship programme. She is the Equality and Diversity Lead, Division of Musculoskeletal and Dermatological Sciences and an Athena Swan champion. She is married to a General Practitioner and has two daughters.
Murlidhar Rajagopalan, MD
Dr. Rajagopalan is a senior consultant and Head of Dept. of Dermatology, Venereology & Leprology at Apollo Hospitals in Chennai, India. Additionally, he serves as senior consultant in pediatric dermatology at Apollo Children's Hospital. He completed an MBBS from JIPMER Madras University in 1985 and an MD in Dermatology from PGIMER Chandigarh in 1989. Dr. Rajagopalan reviews articles for the Indian Journal of Dermatology, Venereology and Leprology and several other national and international journals. He joined the IPC as a councilor in 2006 and currently serves on the IPC education committee.
IPC's mission is to advance the care of people with psoriasis worldwide, through education, research and advocacy.
IPC is not in any way engaged in the practice of medicine or acting as a physician or health care professional or provider. The information IPC publishes is not intended as a substitute for the exercise of professional medical judgement by a health care provider following examination of a patient's condition. The ultimate responsibility for a patient's diagnosis or medical treatment rests with the patient's health care provider.
International Psoriasis Council
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St. Louis, MO USA 63117
Tel (972) 861-0503 Fax (214) 242-3391
email info@psoriasiscouncil.org
© 2020 International Psoriasis Council. All Rights Reserved.


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Takuro Ailing Again
August 4, 2004 - tokyoguy
Another twist in the Avex saga. President Yoda Tatsumi (64) has resigned, leaving the door open for Matsuura Masato (39) and Chiba Ryuhei (40) to return. Taking over as president will be Kobayashi Toshio (39), formerly an executive director, but it is presumed to be only temporarily, until Matsuura assumes the post. Top artist Hamasaki Ayumi (25) is expected to stay with the label, after earlier saying she would leave amidst the accusations (for more details, see earlier stories this week).
• Impersonator Corokke (41) announced during a show last night that he and his estranged wife are back together.
• Folk singer Yoshida Takuro (photo, 58) had to stop halfway through a performance in Tokyo last night. The singer, who became a big star in the 1970s, was diagnosed with cancer last year. He recovered well enough to play a comeback tour last autumn, and had recently started another.
Avex in Chaos
Fumio's Final Journey

redpajama_set_name: RedPajamaCommonCrawl


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5 Tactics To Boost Your Mitochondrial Health & Your Longevity
by Tim Skwiat, MEd, CSCS, Pn2
Okay, friend. I've got some important questions for you. They may seem a little personal, and they're going to require you to be completely honest with yourself. Ready?
As you've gotten older, have you noticed you have less energy and more fatigue? Do you feel like tasks you could once complete without batting an eye are now more physically demanding?
Have you found your joints don't quite recover as quickly as they used to? Have you noticed your stamina is a fraction of what it once was? Do you lack the strength and muscle tone of your youth? Let's be honest… have you noticed the appearance of what seems like a spare tire around your waist?
Do you experience more brain fog and forgetfulness? Do you find it difficult to concentrate on the task at hand? Have you found a "good night's rest" is more difficult to come by?
Does food affect you a bit differently these days? Do you experience more digestive discomfort? Have you noticed you catch colds more often? And when you do, it's more difficult to bounce back?
If you answered yes to any of the above, you're not alone. These are all common age-related issues. While they may seem inevitable, the truth is, in many cases, they can be traced back to your mitochondria. (You may remember learning about the mitochondria in middle and high school biology classes?).
Just to jog your memory, mitochondria are known as the "power plants" of all living things, including us. That is, they are the components of our cells responsible for providing energy in the form of a molecule called ATP. In fact, the mitochondria produce about 95% of the body's energy.
For some perspective, it's estimated that there are over 30 TRILLION cells in the human body. Each cell may contain hundreds of mitochondria, which are especially prevalent in the brain, heart, and muscles. Both mitochondrial number and function are critical. In the absence of a dense network of efficient mitochondria, our ability to live, breathe, move, be energetic, and live life to the fullest is severely compromised.
The truth is that the traditional view of mitochondria as "power plants" (while accurate) is incomplete. In fact, mitochondrial health and function may very well be the "missing link" or so-called "fountain of youth." On the other hand, mitochondrial dysfunction is linked to nearly every age-related human health issue—including those I asked about above.
What Causes Mitochondrial Health Issues?
How does mitochondrial function get compromised? Better said, how does mitochondrial dysfunction arise? Well, it's quite a complex topic that's being intensely researched. However, science is beginning to unravel the mystery, which appears to arise from:
An inadequate number of mitochondria
An inability to provide the necessary materials (e.g., fats, carbs) to mitochondria
Dysfunction in the electron transport and ATP-synthesis machinery
Since that may sound like a bit of a foreign language, allow me to translate. Going back to our "power plant" metaphor, what this means is that mitochondrial dysfunction results from:
A reduction in the number of "power plants"
A "transportation issue" preventing the raw materials from getting into the "power plant"
A problem with the "assembly line" or an insufficient number of "workers"
Factors Affecting Mitochondrial Health
With that in mind, you may be wondering…what variables influence or accelerate mitochondrial dysfunction? Better yet, is there anything you can do to support mitochondrial health?
The answer is a resounding YES. We'll dig into them in just a moment. But first, let's address some of those factors that seem to compromise mitochondrial function:
Persistent, unhealthy levels of inflammation. Interestingly, this is a vicious cycle whereby inflammation impairs mitochondrial function, and subsequent mitochondrial dysfunction elicits inflammation.1
Chronic stress2
Poor glycemic control3
Advanced glycation end-products (AGEs). AGEs, which are "glycotoxins" that can be produced during cooking (e.g., grilling, broiling, frying) and also formed inside the body (typically in line with poor glycemic control or high blood sugar), increase free radical formation, increase oxidative stress, and promote inflammation. Along those lines, they've been implicated in mitochondrial dysfunction. As if that weren't enough, mitochondrial dysfunction is thought to exacerbate the production of AGEs, "fueling the fire" so to speak.4–7
Sedentary lifestyle8
Poor nutrition and overeating. The typical Western-style diet, characterized by a high intake of ultra-processed foods, refined grains, added sugars, and poor-quality fats (i.e., high-fat, high-carb "fast food" diet), is notorious for accelerating many negative health outcomes, including mitochondrial dysfunction.9,10
Insufficient/poor-quality sleep and poor circadian rhythm management. This is, of course, another example of a vicious cycle whereby poor sleep hygiene impairs mitochondrial function. In turn, the ensuing mitochondrial dysfunction adversely affects sleep. Also of note, melatonin, while primarily regarded as a sleep-regulating hormone, is a powerful antioxidant, which is selectively taken up by the mitochondria.11
Environmental stressors and toxins (e.g., heavy metals)12
Certainly, this is not an exhaustive list, but I think you get the point. Arguably, the common denominator between the factors listed above and mitochondrial dysfunction is oxidative stress.
Perhaps you've heard of the Mitochondrial Free Radical Theory of Aging (MFRTA). According to MFRTA, the accumulation of oxidative damage is the main driving force in the aging process.13 While there is some controversy as it pertains to the validity of MFRTA, there is no denying that oxidative damage to the mitochondria impairs mitochondrial health and function. Indeed, it's a driving factor behind mitochondrial dysfunction.14,15
The irony is that the mitochondria themselves are not just a target of oxidative stress—they are the body's main source of reactive oxygen species (ROS), which are highly reactive free radicals. That is, a byproduct of mitochondrial energy production is the creation of ROS. This, in turn, can cause oxidative damage to the mitochondria (e.g., mitochondrial membrane, DNA, etc.) leading to mitochondrial dysfunction.
2 Foods Boost Mitochondrial Health
All hope is not lost! What you eat—or don't eat, as alluded to above—can have a considerable impact on mitochondrial health and function. Given the information provided so far, you may have an idea of what types of foods support mitochondrial health and function.
Plant Polyphenols. Polyphenols are plant-derived compounds with a variety of biological activities and health properties. They are best known for being the most abundant antioxidants found in food. Currently, over 500 different polyphenols have been identified in commonly consumed foods. Most polyphenols have both antioxidant and anti-inflammatory properties. Along those lines, they may have protective effects on mitochondrial functioning.16,17
In addition, certain polyphenols may enhance mitochondrial efficiency and/or stimulate mitochondrial biogenesis, which is science speak for increasing the size and number of mitochondria.18 Here are some of the most noteworthy polyphenols and the foods you can find them in:
Resveratrol: Grape skins (red wine), peanuts, raspberries, blueberries
Quercetin: Onions, oranges, bell peppers, snap beans, capers, tea, green vegetables, berries
Epicatechin: Cocoa, blackberries, tea, apples, peaches
Kaempferol: Parsley, kiwis, oranges, potatoes, apples, strawberries, grapes, watermelon, onions, broccoli, carrots
Anthocyanins: This is a broad category of polyphenols found in a variety of fruits, particularly berries (e.g., blackcurrants, blackberries, strawberries), apples, cherries, grapes, plums, red wine, red cabbage, eggplant, red onions, radishes
Galangin: Oregano
Fisetin: Strawberries, apples, persimmons, onions
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Docosahexaenoic acid (DHA). The omega-3 fats DHA and EPA are highly regarded for a wide range of health benefits. Among them, recent research has shown that these key essential fatty acids may have anti-aging properties.19–21
What's particularly interesting is that EPA, and to a substantially greater extent, DHA are incorporated into the walls of our cells, called cell membranes. Recent research confirms that these omega-3s, particularly DHA, are also incorporated in mitochondrial membranes. And this, my friend, has enormous implications for mitochondrial health and function.22
What's more, DHA can increase the concentration of a compound in the mitochondrial membranes called cardiolipin, which is unique to mitochondria and essential for optimal mitochondrial function. Considering that depletion of cardiolipin results in severe mitochondrial dysfunction, this has tremendous significance.16,23 Practically speaking, healthy mitochondrial levels of DHA and cardiolipin are critical to make sure there are no "transportation issues" with "raw materials" getting into the mitochondria and to ensure the "assembly line" is running smoothly and efficiently.
The best whole-food sources of DHA are oily fish and seafood. (Plant-based eaters, algae and algal oil will be your best options.) When it comes to choosing fish and seafood, you obviously want options that are rich in these essential fats. However, it's also important to take into consideration issues like sustainability and heavy metal toxicity. As alluded to above, mercury is an environmental toxin that can damage mitochondria and lead to mitochondrial dysfunction. Along those lines, the best choices include:
Pacific sardines
Atlantic mackerel
5 Tactics to Boost Mitochondrial Health
In addition to food choices, there are several key tactics that are extremely effective at supporting mitochondrial health and stimulating mitochondrial biogenesis.
1. Exercise. One of the first things you learn in exercise physiology class is that exercise, particularly endurance exercise, increases mitochondrial health in muscle. As you might imagine, this adaptation is one of the primary ways you can improve your aerobic capacity and endurance performance.
We don't have to get into the nitty gritty details. What's important to know is that regular exercise is a potent stimulator of mitochondrial biogenesis. On the other hand, the "use it or lose it" mantra holds true. That is, being sedentary provokes a decrease in mitochondrial number and function.8,18
While traditional aerobic exercise, which is indeed effective at increasing mitochondrial content in muscles, is typically the first thing that comes to mind, recent research shows even low-volume, short-duration, high-intensity interval training (HIIT), which involves brief periods of intense effort interspersed with rest intervals, is highly effective at stimulating the "master regulator" of mitochondrial biogenesis (a compound called PGC-1α).24,25
2. Caloric Restriction. From a nutrition standpoint, arguably the most effective means of promoting mitochondrial health, function, and biogenesis is caloric restriction (CR). Indeed, multiple lines of research have shown that CR reliably promotes healthy aging and extends lifespan.
This can be traced back, at least in part, to improvements in mitochondrial size, number, and function. CR protects mitochondria by reducing the production of free radicals. What's more, CR activates the key anti-aging compounds SIRT1 and AMPK, which are cellular energy sensors that up-regulate mitochondrial biogenesis.18
If you like to eat, and daily caloric restriction, which can involve cutting calories by 30 – 40%, doesn't sound appealing to you, you might consider experimenting with intermittent fasting (IF). IF may offer similar mitochondrial and longevity benefits. It's been shown to up-regulate a process called autophagy, which essentially involves "cleaning up" cellular garbage (including damaged mitochondria). As an added benefit, whereas CR typically results in the loss of calorie-burning lean muscle, IF promotes fat loss while retaining valuable lean mass.26
While time-restricted feeding (TRF), which involves limiting daily eating to a short window (e.g., 6 – 8 hours), is the most commonly practiced form of IF, alternate day fasting (ADF) and fast-mimicking diets (FMD) may offer similar, if not greater, benefits. For example, FMD, which entails following a low-calorie, low-protein diet for a 5-day period during a monthly cycle, has been shown to significantly reduce biomarkers for aging, increase regeneration markers, and promote optimal lifespan and healthspan in humans.27,28
3. Ketogenic Diet. Speaking of fasting, the ketogenic diet, or keto for short, essentially simulates fasting from a metabolic standpoint. That is, a hallmark of fasting is that the body switches from a reliance on glucose to an "alternative fuel," known as ketones. As you might imagine, the ketogenic diet is specifically designed to upregulate ketogenesis, or the body's production of ketones.
Similar to fasting and CR, keto upregulates important cellular processes, promoting stress resistance and autophagy, which, as you may recall, is a form of "cellular detoxing."29 Pretty cool stuff! While it can get a little complex, the ketogenic diet also activates key anti-aging compounds, such as PGC1α, AMPK, and SIRT1.29
You don't have to remember the alphabet soup. What's important is that these compounds help increase the number of mitochondria (via mitochondrial biogenesis). These compounds are also known as "exercise mimetics."30 In other words, activating them through the ketogenic diet may offer some of the same beneficial effects as endurance exercise.
What's more, by its very nature, the ketogenic diet, which is a very-low-carb, high-fat diet, results in significant reductions in blood sugar levels and subsequent improvements in glycemic control. As you may recall from above, poor glycemic control is one of the primary variables contributing to mitochondrial dysfunction.
An additional point to mention is that dysfunctional mitochondria may have an impaired ability to use glucose for fuel (i.e., a "transportation issue" or "assembly line" issue). Along those lines, ketones have the ability to serve as a critical alternative energy source for damaged mitochondria.31
One more thing to mention is that ketones are a very clean, efficient source of energy. By that, I mean that your body can generate more cellular energy from ketones than glucose or fat. That also means when your body metabolizes ketones, it generates fewer ROS. This is important because, as you may recall, oxidative damage is arguably the primary driving factor of mitochondrial dysfunction.
4. Hypo- and Hyperthermia. In addition to the strategies mentioned above, exposure to low temperatures is a key driver of mitochondrial biogenesis, which again refers to increasing mitochondrial number, size, and mass.18 This is often referred to as cold-induced mitochondrial biogenesis. What's particularly interesting is that this seems to occur preferentially in brown adipose tissue (BAT), also known as "brown fat."32 Unlike unwanted body and belly fat, BAT is unique in that it burns body fat to produce heat (i.e., thermogenesis). As a result, BAT thermogenesis is currently being investigated as an anti-obesity target.33,34
In addition, research has shown that regularly taking ice-cold baths (known as "cold water immersion," or CWI) increases markers (e.g., AMPK) of mitochondrial biogenesis in muscles.35 Interestingly, if you want to derive the greatest benefits, CWI should be combined with exercise. In other words, when exercise is performed in cold temperatures or CWI is used as a recovery tool after exercise, mitochondrial biogenesis is enhanced.36
So, if cold therapy can boost mitochondrial health, what about heat exposure? It's hard to say for certain, but we may be able to speculate about some potential benefits of regular heat therapy, in particular sauna bathing. For starters, during a sauna session, heart rate can increase up to 100 beats/minutes and reach up to 150 beats/minutes. In case you didn't know, that's fast! In fact, that's similar to low- to moderate-intensity exercise.
That's not to say sauna bathing is a replacement for exercise. But as you'll recall from above, aerobic exercise is traditionally known as the most potent stimulus to support a dense network of efficient mitochondria. Along those lines, there are multiple documented heart health and longevity benefits seen with sauna bathing (such as reduced risks of cardiovascular disease and all-cause mortality), which are quite similar to those adaptations to regular physical exercise.1
5. Mitochondrial Support Supplements. Of course, dietary supplements can offer additional mitochondrial support and anti-aging benefits. Along those lines, I'm excited to share with you what I like to call my MitoSupport Stack:
BioTrust Ageless Body®. With Ageless Body, providing unparalleled antioxidant support is the name of the game. In CoQ10, CurcuWIN® (i.e., curcumin), Setria® Glutathione, and Vitamin C, you have a strong cast of antioxidants on your side to protect your mitochondria from ROS and oxidative damage. In addition, CoQ10 is a key component of the mitochondrial electron transport chain. You can think of it as the "foreman" of the "assembly line."Meanwhile, curcumin not only activates the "master regulator of antioxidant response," it also defends against mitochondrial toxins and promotes mitochondrial biogenesis. Glutathione, known as the "key survival antioxidant," has emerged as the main line of defense for the maintenance and repair of mitochondria.
Interestingly, studies have demonstrated low levels of vitamin C in folks with mitochondrial dysfunction while high vitamin C levels have been shown to have an impact on both the number and size of mitochondria.
Finally, Sensoril® Ashwagandha, which is prized for its rejuvenating and energizing effects, not only supports mitochondrial function, it also helps increase stress resilience and lower cortisol. This is significant because chronic stress can generate toxic by-products, promote systemic inflammation, and alter gene expression, ultimately damaging mitochondria and accelerating cellular aging.
BioTrust IC-5™. As previously discussed, poor glycemic control is a primary contributor to mitochondrial dysfunction. When it comes to improving carb tolerance, IC-5 stands in a class of its own. For example, research-backed ingredients like Berberine and Cinnamon Extract have been shown to significantly reduce the glycemic response when taken prior to a carbohydrate-containing meal.What's more, Berberine, Cinnamon Extract, Naringin, and Benfotiamine all have noteworthy antioxidant properties, critical for protecting mitochondrial health and function.
Berberine also activates the key anti-aging enzyme AMPK, which, as you may recall, is also a known stimulator of mitochondrial biogenesis.
And if all that wasn't enough, Benfotiamine has been shown to reduce levels of AGEs, those glycotoxins that are known to accelerate cellular aging and thought to contribute to mitochondrial dysfunction.
I know all that may seem like a lot of complex information to process. The truth is that the body is incredibly intricate. What we hope you walk away with is a greater appreciation for these extremely important "power plants" that reside in every cell in your body and have far-reaching effects. Even more, we want you to gain an appreciation for the fact that many lifestyle factors—the choices YOU make—can have a substantial effect on the size, number, and efficiency of your mitochondria. Ultimately, that effects the function of every cell in your body—and the quality of your life. But worry not, my friend, we'll be here every step of the way to help you sort it out. So, let us know if you have any questions or feedback.
Here's to your mitochondrial health!
Tags: DHAenergyketogenicmitochondriaomega-3Polyphenolspower
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Tim Skwiat, MEd, CSCS, Pn2
Tim has a Master's degree in Sports Science & Nutrition, he is a Precision Nutrition L2 Nutrition Coach and a NSCA Certified Strength and Conditioning Specialist, and he proudly serves as BioTrust's Director of Scientific Affairs. Tim has coached hundreds of clients and written dozens of evidence-based articles covering health, nutrition, and fitness. Tim lives in Austin, Texas, with his beautiful wife Amie and precious daughter Parker Ashlee. Tim and Amie are passionate about helping people live better, healthier, and more meaningful lives.
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14. Trifunovic A, Larsson N-G. Mitochondrial dysfunction as a cause of ageing. J Intern Med. 2008;263(2):167-178. doi:10.1111/j.1365-2796.2007.01905.x.
15. Payne BAI, Chinnery PF. Mitochondrial dysfunction in aging: Much progress but many unresolved questions. Biochim Biophys Acta BBA - Bioenerg. 2015;1847(11):1347-1353. doi:10.1016/j.bbabio.2015.05.022.
16. Serrano J, Cassanye A, Martín-Gari M, Granado-Serrano A, Portero-Otín M. Effect of dietary bioactive compounds on mitochondrial and metabolic flexibility. Diseases. 2016;4(1):14. doi:10.3390/diseases4010014.
17. Panickar KS, Jang S. Dietary and plant polyphenols exert neuroprotective effects and improve cognitive function in cerebral ischemia. Recent Pat Food Nutr Agric. 2013;5(2):128-143.
18. Jornayvaz FR, Shulman GI. Regulation of mitochondrial biogenesis. Essays Biochem. 2010;47. doi:10.1042/bse0470069.
19. Kiecolt-Glaser JK, Epel ES, Belury MA, et al. Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial. Brain Behav Immun. 2013;28:16-24. doi:10.1016/j.bbi.2012.09.004.
20. Farzaneh-Far R, Lin J, Epel ES, Harris WS, Blackburn EH, Whooley MA. Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA. 2010;303(3):250-257. doi:10.1001/jama.2009.2008.
21. Farzaneh-Far R, Lin J, Epel E, Lapham K, Blackburn E, Whooley MA. Telomere length trajectory and its determinants in persons with coronary artery disease: Longitudinal findings from the heart and soul study. PloS One. 2010;5(1):e8612. doi:10.1371/journal.pone.0008612.
22. Herbst E a. F, Paglialunga S, Gerling C, et al. Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle. J Physiol. 2014;592(6):1341-1352. doi:10.1113/jphysiol.2013.267336.
23. Stanley WC, Khairallah RJ, Dabkowski ER. Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids. Curr Opin Clin Nutr Metab Care. 2012;15(2):122-126. doi:10.1097/MCO.0b013e32834fdaf7.
24. Vincent G, Lamon S, Gant N, et al. Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training. Front Physiol. 2015;6. doi:10.3389/fphys.2015.00051.
25. Gibala MJ, Little JP, MacDonald MJ, Hawley JA. Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol. 2012;590(Pt 5):1077-1084. doi:10.1113/jphysiol.2011.224725.
26. Mattson MP. Challenging oneself intermittently to improve health. Dose-Response. 2014;12(4):600-618. doi:10.2203/dose-response.14-028.Mattson.
27. Longo VD, Panda S. Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell Metab. 2016;23(6):1048-1059. doi:10.1016/j.cmet.2016.06.001.
28. Brandhorst S, Choi IY, Wei M, et al. A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan. Cell Metab. 2015;22(1):86-99. doi:10.1016/j.cmet.2015.05.012.
29. Paoli A, Bianco A, Damiani E, Bosco G. Ketogenic diet in neuromuscular and neurodegenerative diseases. BioMed Res Int. 2014;2014. doi:10.1155/2014/474296.
30. Narkar VA, Downes M, Yu RT, et al. AMPK and PPARδ agonists are exercise mimetics. Cell. 2008;134(3):405-415. doi:10.1016/j.cell.2008.06.051.
31. McInnes J. Mitochondrial-associated metabolic disorders: Foundations, pathologies and recent progress. Nutr Metab. 2013;10:63. doi:10.1186/1743-7075-10-63.
32. Klingenspor M. Cold-induced recruitment of brown adipose tissue thermogenesis. Exp Physiol. 2003;88(1):141-148.
33. Chechi K, Nedergaard J, Richard D. Brown adipose tissue as an anti-obesity tissue in humans: Brown fat in humans. Obes Rev. 2014;15(2):92-106. doi:10.1111/obr.12116.
34. Wang S, Liang X, Yang Q, et al. Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1. Int J Obes. 2015;39(6):967-976. doi:10.1038/ijo.2015.23.
35. Ihsan M, Markworth JF, Watson G, et al. Regular postexercise cooling enhances mitochondrial biogenesis through AMPK and p38 MAPK in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2015;309(3):R286-294. doi:10.1152/ajpregu.00031.2015.
36. Zak RB, Shute RJ, Heesch MWS, et al. Impact of hot and cold exposure on human skeletal muscle gene expression. Appl Physiol Nutr Metab Physiol Appl Nutr Metab. 2017;42(3):319-325. doi:10.1139/apnm-2016-0415.
brain foods


text:
Q: Program Exits Before Finishing Question below context
Context: For this program to be submitted and work properly I need to be able to input 8.68 for the amount that gets scanned in. The program then needs to be able to calculate how many of each coin type needs to be given as well as the remaining balance after you give x amount of the coin
What the output should look like
Question/Problem: My program will run until the quarters and get it all correct, once it gets to the dimes, where it has 0 dimes, the program breaks and will exit. (Even when I use a different amount in the beginning, it will break at a different point if the amount of coin, in this instance the dimes have a value of 0) What can I do to ensure that it will run and finish the same as the output shown above.
Code:
#include <stdio.h>

int main()
{
    double amount;
    double GST = 1.13;
    double balance;
    int numLoonies;
    int numQuarters;
    int numDimes;
    int numNickels;
    int numPennies;
    int bal;

    printf("Please enter the amount to be paid: $"); //ask how much to be paid
    scanf("%lf", &amount);      //scans the input

    GST = amount * .13 + .005;

    printf("GST: 1.13\n");

    balance = (amount + GST);
    printf("Balance owing: $%.2lf\n", balance);

    numLoonies = balance;
    bal = ((balance - numLoonies)*100);

    printf("Loonies required: %d", numLoonies);
    printf(", balance owing $%1.2f\n", (float)bal/100);

    numQuarters = bal / 25;
    bal = bal % (numQuarters*25);

    printf("Quarters required: %d", numQuarters);
    printf(", balance owing $%1.2f\n", (float)bal / 100);

    numDimes = bal / 10;
    bal = bal % (numDimes * 10);

    printf("Dimes required: %d", numDimes);
    printf(", balance owing $%1.2f\n", (float)bal / 100);

    numNickels = bal / 5;
    bal = bal % (numNickels * 5);

    printf("Nickels required: %d", numNickels);
    printf(", balance owing $%1.2f\n", (float)bal / 100);

    numPennies = bal / 1;
    bal = bal % (numPennies * 1);

    printf("Pennies required: %d", numPennies);
    printf(", balance owing $%1.2f\n", (float)bal/100);

    return 0;
}

Update So this is for a school project, should have mentioned that, but I have to use the mod to find the remaining balance, and I had to cast the double into an int as part of the criteria.
And yes, Canada doesn't have pennies any more but I still have to do it this way

A:
(Even when I use a different amount in the beginning, it will break at a different point if the amount of coin, in this instance the dimes have a value of 0)

That's a big clue. So let's look at the dimes...
bal = bal % (numDimes * 10);

So, let's say numDimes is 0. Then (numDimes * 10) is also zero. What do you think happens when you try to calculate bal % 0? If you're not sure, you could put that expression into your program and try it.
Another issue is that I don't think you really mean to say bal % (numDimes * 10). Let's say numDimes works out to be 3 for some starting balance... in that case you've got bal % (3 * 10) or bal % 30. Is that really what you want? That'd give some number between 0 and 29, when you probably really want a number that's less than the value of a single dime. If I've got 79 cents and I take out 7 dimes, then 79 % 70 does give the 9 that I should have left over, but it's not the most intuitive way to get there.

A: Step 1 - Convert money into whole numbers of the lowest unit.
Since code is to count to the "penny", take input and round/convert to whole number of cents.
#include <math.h>
double amount;
printf("Please enter the amount to be paid: $"); //ask how much to be paid
scanf("%lf", &amount);
long iamount = lround(amount * 100);

Same with GST
double GST = 1.13;
long itax = lround(iamount * (GST - 1)); // round to the nearest penny
long ibalance = iamount + itax;
printf("Balance owing: $%.2lf\n", ibalance/100.0);

2) Proceed to break down into coins
OP's bal = bal % (numCoins*CoinValue); is not the right approach.
long CoinDenomination = 100; // 100 cents to the Loonie
long iLoonies = ibalance/CoinDenomination;
printf("Loonies required: %ld", iLoonies);
ibalance %= CoinDenomination;

...

CoinDenomination = 10; // 10 cents to the Dime
long iDimes = ibalance/CoinDenomination;
printf("Dimes required: %ld", iDime);
ibalance %= CoinDenomination;

A:
Because of the way numDimes is calculated, it will always produce the correct answer as long as numDimes > 0. But bal % 10 will produce the same result. – Barmar

So what I ended up doing was easier than I originally thought I was going to have to do, I just used mod coin value. Thanks for all the comments :)

redpajama_set_name: RedPajamaStackExchange


For a holiday packed with sun, sea and sand, travel to Fuerteventura. Groups of six will find Villa Flores a brilliant choice, thanks to its attractive location and furnishings. You'll be based right next to the pretty golf course of Caleta de Fuste too. Three spacious bedrooms, two bathrooms and an open-plan kitchen offer loads of space for families and friends to relax - the television and DVD player are huge hits with kids. The roman-style pool outside is yours to enjoy and thanks to the covered terrace and built-in barbecue, you can dine al fresco morning, afternoon and night! There's a handy supermarket nearby and the local area is scattered with delicious restaurants and trendy bars. The popular area of Corralejo with its National Park is also less than an hours drive away.
Villa Flores Fuerteventura is located in Caleta de Fuste, Fuerteventura.


"It was like losing a family member," said Blanche Weigand, whose mother immigrated from Poland to Chicago in 1950. "I'm from Chicago, but my heart is in Poland."
Weigand grew up speaking fluent Polish and eating her mother's pierogi, and stays in touch with her Polish cousins each week through Skype.
The nation is in mourning after the crash, which occurred in Russia near Katyn forest. The dignitaries had been on their way to Katyn to commemorate the 70th anniversary of the massacre there of thousands of Polish officers by Soviet forces.
Weigand said the crash makes her want to go to Poland, while her 88-year-old mother hasn't been able to talk about the tragedy at all. Instead, she cries, is plagued by headaches and recounts painful memories of being captured by Nazis.
"She's reliving all of it and it hurts," Weigand said.
Families of Polish descent packed churches in Chicago, London and elsewhere. At London's St. Andrew Bobola Polish Roman Catholic Church, parishioners mourned one of their priests, Monsignor Bronislaw Gostomski, who died in the crash, along with Ryszard Kaczorowski, the last president of a Polish government-in-exile based in London during World War II and the communist years.
"When the Polish people have any kind of a tragedy, they pray, they go to church," said Anna Szpindor, who was born in Poland and went to medical school there but lives in South Barrington, Ill.
"They feel this solidarity, this unity in a church environment," the 55-year-old said before she entered Holy Trinity Catholic Church in Chicago.
In New York, several hundred people stood outside St. Stanislaus Kostka Roman Catholic Church in Brooklyn, unable to squeeze into its Polish-language Mass.
There are also significant populations of Polish descendants in Argentina and southern Brazil. In Curitiba, Brazil, special Masses were celebrated Sunday morning to honor those killed in the plane crash, the Rev. Zenon Sikorski said.
The Argentine-Polish Cultural Association issued a statement saying it shares Poland's "profound pain over the tragic accident."
An estimated 300,000 Poles emigrated to Argentina between 1897 and 1950. Laborers mostly went to larger cities like Buenos Aires, Cordoba and Rosario, while those with farming backgrounds principally settled in the northeast.
Dozens of mourners in the Chicago area, home to the largest concentration of people of Polish descent outside of Poland, came Sunday to the largely Polish St. Adalbert Cemetery in suburban Niles, Ill. They paid homage at a memorial sculpture to the 1940 Katyn massacre, which was designed by Chicago artist Wojciech Seweryn, who was also killed in the crash.
The sculpture — featuring the Virgin Mary holding a wounded officer — was covered with hundreds of candles, flowers and Polish flags. Two journals lay at the memorial sculpture, filled with hundreds of entries in Polish expressing sorrow, grief and shock.
"It is a great disappointment for Poland, this tragedy happened with Polish officers in 1940, now with the president in 2010," one read.
Another read simply, "Never Forgotten."
Many immigrants said they still have strong ties to Poland, with family or property there. Many make regular trips home, and some plan to eventually move back.
"The Poles keep their ties to Poland, that's just a fact," said the Rev. Anthony Bus, pastor of St. Stanislaus Kostka Church, the first Polish parish in Chicago. It opened in 1867.
Maria Balcer, 65, a recent immigrant, sat in a pew at Polish National Catholic Church in Brooklyn and cried. She had been up until 2 a.m. watching television coverage of the crash, she said.
"The tragedy is terrible, a horrible feeling in my heart," she said.
Teresa Karwowska, 56, her husband, Antoni Karwowski, 56, and their family attended a Polish Mass on Sunday morning and planned to attend a memorial service that day for the crash victims.
"What happened on Saturday, it kind of opened people's eyes to what happened in the Katyn massacre," Karwowska said, in Polish translated by her son. She said the family would observe a week of mourning for the plane crash victims with no music, no sports and prayer.
Associated Press Writers Caryn Rousseau in Chicago, Karen Matthews in New York, Tales Azzoni in Sao Paulo and Debora Rey in Buenos Aires, Argentina, contributed to this report.


In the field of minority entrepreneurship, sociologists and economists have written most of the influential studies, yet these groups typically ask different questions and base their analysis on different assumptions. The literature predictably lacks a single unifying focus and is quite diverse regarding issues explored and methodological approaches employed. Differing approaches and their outcomes are summarized and critically probed in this review. My intent is to illuminate strengths and weaknesses — along with patterns of common findings — in this voluminous literature.
Minority-owned businesses are collectively reflections of evolving constraints and opportunities operating in broader society. Minorities seeking to create viable business ventures have traditionally faced higher barriers than whites as they sought to exploit market opportunities, raise financing, and penetrate mainstream networks. Entrepreneurial dynamics are clarified by focusing upon specific contexts in which firms are being shaped by prevailing opportunity structures. Progress has been noteworthy overall for minority-owned businesses, in part because barriers impeding their collective development have been gradually declining.
The dominant methodological approaches and findings of economists and sociologists in the minority entrepreneurship literature are, ultimately, highly complementary. Sociologists have posed bolder questions while economists have paid more attention to pinning down causeand-effect relationships, yet their findings have been gradually moving towards convergence over the past two decades. It is possible — and desirable — that these respective bodies of work may someday merge, creating a minority entrepreneurship scholarly synthesis.
Minority Entrepreneurship reviews the economic and sociological literature on the topic of minority entrepreneurship. While economists and sociologists have written most of the influential studies, these groups typically ask different questions and base their analysis on different assumptions. The literature predictably lacks a single unifying focus and is quite diverse regarding issues explored and methodological approaches employed. Differing approaches and their outcomes are summarized and critically probed in this monograph with the intent is to illuminate strengths and weaknesses – along with patterns of common findings – in this voluminous literature. Minority-owned businesses are collectively reflections of evolving constraints and opportunities operating in broader society. Minorities seeking to create viable business ventures have traditionally faced higher barriers than whites as they sought to exploit market opportunities, raise financing, and penetrate mainstream networks. Entrepreneurial dynamics are clarified by focusing upon specific contexts in which firms are being shaped by prevailing opportunity structures. Progress has been noteworthy overall for minority-owned businesses, in part because barriers impeding their collective development have been gradually declining. Minority Entrepreneurship shows that the dominant methodological approaches and findings of economists and sociologists in the minority entrepreneurship literature are highly complementary. Sociologists have posed bolder questions while economists have paid more attention to pinning down cause-and-effect relationships, yet their findings have been gradually moving towards convergence over the past two decades. This books posits that it is possible and desirable that these respective bodies of work may someday merge, creating a minority entrepreneurship scholarly synthesis.


The selected candidate should ideally be able to start as of 20th May 2018. The deadline for applications is Monday 29th April 2019 however please send in your application ASAP as screening will be done an ongoing basis.
Applications should be sent electronically to jobs@migpolgroup.com with the subject line "Office Manager". No paper application will be accepted.
The deadline for applications is Monday 29 April 2019.
Interviews will be held as of 6 May 2019.


text:
AHA Teaching & Learning Teaching Resources for Historians Teaching and Learning in the Digital Age Linking Family History and World History Connections to World History
Bridging the Digital Divide
Note to Instructors
Photoanalysis of a Family Photograph
Finding the Historical Context for the Family Photograph
Sephardic Jews and Their History
The Ladino Language
Sara's Story
Jacob's Story
Morris's Story
Clara's Story
Photoanalysis of the Marriage Photograph
How This Family History Project Has Been Researched
Connections to World History
The story of the Sarfaty family may be connected with several aspects of world history. These aspects may be divided into two categories: specific events and topics and thematic elements in the world history survey.
Specific events and topics in history
The principal events in world history that directly pertain to the story of the Sarfaty family and its members are:
The expulsion of the Jews from Spain after 1492
The Balkan Jews under the Ottoman Turkish Empire
The modern Balkan nations from 1900-1914
The origins of World War I
U.S. immigration patterns
Social and cultural life in New York City, 1920-1940
Thematic elements in the world history survey
The Sarfaty story lends itself to a variety of unifying themes or topical approaches that are often used to link material in a world history survey course. Topics that can be used successfully to link the Sarfaty family story are:
Migration or population movements (diasporic flow from Spain, emigration from Balkans, internal migration within the U.S.)
Economic life (pre-industrial sources of livelihood in Monastir, struggle for economic survival in the U.S. under industrial conditions)
Gender and history (differential experiences of male and female family members)
Development of technology (military technology in Europe prior to WW I, twentieth century transportation technology to facilitate trans-oceanic migration, industrial technology as the setting for work in the US)
Adaptation to the physical environment (Importance of serious diseases in a family's history, such as tuberculosis, diphtheria and small pox.)
"Doing World History"
Using David Smith's typology from "Doing World History," the Sarfaty family material can be linked to the five methods as follows:
1. Big Picture: Construct a timeline of the Sarfaty family history from the 1880's-1930's and link the family timeline to the broader timeline of world history during the same period.
2. and 3. Diffusion or spread of artifacts, ideas or other cultural creations from one civilization to others; and, Syncretism or mixing of elements from two of more cultures that resulted in a new civilization: Investigate the culture of the Sephardim under the Ottoman Turks in the nineteenth century both as a product of diffusion from the Spanish homeland to new lands and as a syncretic blend of Turkish and Spanish elements. Another topic is the transformation of Sephardic culture and society in the United States in the early 20th century.
4. Comparison of similarities and differences among civilizations: Compare and contrast Muslim Spain with Christian Spain, the Balkans under Ottoman rule with the modern Balkans and the early twentieth century US from the perspective of the Jewish populations.
5. Common phenomena shared by two or more societies, such as environmental features, technology and/or human development: Compare features of Macedonia and the US in the early twentieth century in terms of physical environment, technological level and social patterns..
Reflective Questions
What specific events and topics in world history are germane to the history of the family you are studying?
How does the timeline of the family you are studying relate to the timeline of world history?
How does the family history connect to the thematic elements described above and/or to at least one of the approaches in "Doing World History"?


Remember those sleeves that I cut off the pajama shirt yesterday? Well, I couldn't just throw them away could I???
Nope, those sleeves were just the perfect size for some baby doll pants, and Madeline needed some pajama pants. Christine is always telling me that Madeline needs more clothes.
Do the baby dolls in your house need some pants? If you have some shirt sleeves, you can sew these up in less than 30 minutes. Which is good because if you use up the scraps immediately it's resourceful and kinda of awesome. If you hang on to the scraps of a t-shirt for "someday I will do this" you become that crazy lady. You don't want to be that crazy lady.
If you were curious, our baby doll is a 12-inch "You and Me" doll. The sleeve scraps were from a size 3T pajama top.
Match the two legs together, and pin together.
Sew together. I used a zig zag stitch on my sewing machine.
Turn right side out, and they are looking like pants already!
Now, with a 1/4" wide elastic measure the waist of your baby doll. You want it to stretch a little bit.
Attach to the top of the pants. The elastic will be a little bit smaller than the waist of the pants.
Sew with a zig zag stitch. You will have to stretch the elastic as you sew.
Go find that baby doll and get her dressed in her new pj pants!
My little kid has this doll too! Only his name is Toto. Nice tutorial!
Sweet idea! The jumper of my girls doll is so old that your tutorial will save my day! Thanks a lot!
looks like a great idea so I can make pajama pants for the American Girl doll I have that is being passed down from me . I have had it since I was at least 7 I am now 40 and I told myself if I ever had any nieces or cousins It would go to them.


text:
Jennifer Lawrence Was "Devastated" She Didn't Get This 1 Movie Role
And reveals what she thinks of the actress who did - by Anna McClelland
She's landed her fair share of covetable parts (from her big break, the Hunger Games franchise, to award-winning roles in films like Silver Linings Playbook) but Red Sparrow star Jennifer Lawrence is still wistful about the one that got away.
Speaking on the Howard Stern SiriusXM radio show, Lawrence opened up about the one audition she was "devastated" to lose.
"Emma Stone and I had this conversation once, 'cause we used to always audition for the same thing, which now seems silly because our careers are so different," Lawrence begins. "She got one thing that I was dying for, but the one thing that really killed me, the only time I've ever been truly devastated by losing an audition – because most of the time you're like, 'eh, wasn't meant to be, move on, what can you do?' – was Tim Burton's Alice in Wonderland."
"That one devastated me," she adds.
Of course, that role went to Australian actress Mia Wasikowska, who Lawrence says was "perfect and amazing" as Alice.
Jennifer Lawrence Tells: "The Women Who Made Me"
The 7 Most Stunning Oscars Beauty Looks
Jennifer Lawrence Got Caught Trolling Emma Stone At The Oscars
Jennifer Lawrence's Reason For Missing The Golden Globe After Parties Is So Funny
The Creepy Story Behind Jennifer Lawrence And Emma Stone's Friendship
The Best Dressed On The Governors Awards Red Carpet
The 10 Best Dressed On The Toronto Film Festival Red Carpet
Jennifer Lawrence Says Filming *That* Scene In 'Don't Look Up' Was The Worst Day Of Her Life
Netflix's 'Don't Look Up' Is A Fictional Comedy With Confronting Real-Life Parallels
Jennifer Lawrence's Knockout Maternity Fashion Show Continues With A Perfect Polka Dot Dress
A Pregnant Jennifer Lawrence Just Dressed Her Baby Bump In A Shimmering Dior Gown For Latest Red Carpet Premiere
Jennifer Lawrence And Amy Schumer Stand In Solidarity At A Rally For Abortion Rights
Jennifer Lawrence & Leo DiCaprio's Dark Comedy 'Don't Look Up' Now Has A Release Date
Disney Are Already Working On A 'Cruella' Sequel, Here's What We Know So Far


text:
Liam Hurst (born 2 September 1994) is an English footballer who plays for  side Shepshed Dynamo, where he plays as a forward.

Playing career

Cambridge United
Hurst left Cambridge United in May 2015 having made six league appearances.

Statistics

References

External links

1994 births
Living people
English footballers
Association football forwards
Cambridge United F.C. players
Cambridge City F.C. players
Corby Town F.C. players
St Neots Town F.C. players
King's Lynn Town F.C. players
Coalville Town F.C. players
Shepshed Dynamo F.C. players
National League (English football) players
English Football League players

redpajama_set_name: RedPajamaWikipedia


text:
European Commission grants approval for Novartis's Signifor to treat acromegaly
Swiss drug-maker Novartis has received approval from European Commission for its Signifor (pasireotide) intramuscular injection to treat adult patients suffering from acromegaly.
The approval was granted for Signifor as a new long acting release formulation for once monthly intramuscular injection to treat adult patients with acromegaly.
This is designed for people without the option of surgery or who have not been curative, and who are inadequately controlled on treatment with a first-generation somatostatin analogue (SSA).
Novartis Oncology president Bruno Strigini said: "Acromegaly that is not properly controlled can have a devastating impact on the long-term health of patients living with this serious pituitary disorder.
"This first approval of Signifor in acromegaly marks a much needed advance in the treatment of this rare disease and we are working hard to bring this therapy to this underserved patient population worldwide in the near future."
"The approval was granted for Signifor as a new long acting release formulation for once monthly intramuscular injection to treat adult patients with acromegaly. "
Approval was based on data from two multicentre Phase III trials, C2402 and C2305, which assessed patients with inadequately controlled acromegaly on first-generation SSAs, and medically naive patients who were post-surgery, or newly diagnosed patients for whom surgery is contraindicated.
Signifor proved its efficacy in providing biochemical control as measured by both growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels, compared against Sandostatin LAR or Somatuline Autogel, in both trials.
A long-acting and injectable depot formulation of octreotide acetate, Sandostatin LAR received approval in the European Union (EU) to treat patients with acromegaly in whom surgery is inappropriate or ineffective.
It can also be used in the interim period until radiotherapy becomes fully effective, under recently finalised label harmonisation.
Sandostatin LAR is available from Novartis for different uses, and is not available in all indications in every country.
Image: The hand of a patient with acromegaly (right) compared with the hand of an unaffected person (left). Photo: courtesy of Philippe Chanson and Sylvie Salenave.
Atlantic Coast Crushers
Crushers and Lump Breakers
DrM, Dr. Mueller AG
Filtration and Mixing Equipment for Pharmaceutical Solid-Liquid Separation
A leading provider of high-quality, system-critical elastomer components, shortlisted in the ENVIRONMENTAL IMPACT category in the 2021 Excellence Awards
Asia-Pacific has seen the largest growth in oncology-related trials over the past decade
Asia-Pacific has seen the largest growth in metabolic disorders-related trials over the past decade
The Middle East has seen the largest growth in infectious disease-related trials over the past decade


text:
Alfred Landé (13 de desembre de 1888, Elberfeld, Rin del Nord-Westfàlia, Alemanya — 30 d'octubre de 1976, Columbus, Ohio, Estats Units) fou un físic alemany, nacionalitzat estatunidenc, que realitzà important aportacions en el camp de l'estructura atòmica i la mecànica quàntica.

Vida
Alfred Landé era fill d'Hugo Landé i de Thekla Landé (1864-1932). Inicià els seus estudis superiors a la Universitat de Marburg, després està un any i mig a la Universitat de Munic i passà a la Universitat de Göttingen en conegué Max Born. Foren les dues úniques universitats alemanyes on es realitzà recerca en mecànica quàntica. El tercer any el cursà a Munic on entrà al cercle d'Arnold Sommerfeld i començà la tesi doctoral amb ell. El 1912 es traslladà a la Universitat de Göttingen, per a treballar amb Max Born, perquè estava més interessat en la física teòrica que en l'experimental. Rebé el doctorat en física el 1914 sota la direcció de Sommerfeld. Dues setmanes després començà la I Guerra Mundial (1914-1918) i Landé serví a l'exèrcit amb Born a Berlín, on treballaren amb tècniques de detecció sonora a l'Artillerie Prufungs-Kommission i establiren una estreta relació. Anà a Frankfurt del Main el 1920 on el 1922 s'hi dugué a terme l'experiment de Stern-Gerlach. El 1922 anà a la Universitat de Tübingen on hi quedà de professor nou anys. El 1931 acceptà una plaça a la Universitat d'Ohio a Columbus, Estats Units, on hi quedà fins a la seva jubilació el 1960.

Referències

Físics alemanys
Persones d'Elberfeld
Alumnes de la Universitat de Göttingen
Alumnes de la Universitat de Munic
Morts a Ohio
Científics de Rin del Nord-Westfàlia


'Breathe' ..appreciate any observations re mix. Thanks.
Thread: 'Breathe' ..appreciate any observations re mix. Thanks.
Great - agree with what's been said - the main vocal could go up a dB or 2 - about half way through it seems to do that anyway - also backing vocals could go up a tad level or maybe eq +2/3 dB around 2khz. Re limiter it all sounds good to me - is it a de-esser you're thinking about.
..re de-esser, i'm afraid that will take away from the high end of the EQ which I do not want to do. I'll give it a try though. My best bet might be to just hack peaks off of the wav. I'm new to reaper (this), Will try that when I figure out how. Thanks!
Super cool idea and overall mix sounds solid. Only critique might be the drums could sound a bit wetter. The bass is adequate, but I kept envisioning how much cooler a more aggressive, perhaps even slap bass part would sound.
Breathing. I don't think I can breathe.


text:
PRC names NEU as one of top performing schools with 100% passing rate in Real Estate Appraisers Licensure Exams
Posted by DCY on October 8, 2021
More in Education:
New Era University declares Jan. 17-22 recovery break amid CHED pronouncement on academic break January 14, 2022
UN urges full reopening of South Asia schools amid learning loss December 9, 2021
China passes law to reduce pressure on children from homework October 23, 2021
File photo showing the facade of New Era University's main campus in Quezon City.
(Eagle News) – New Era University (NEU) was one of two schools that ranked no. 1 in the Professional Regulation Commission's list of top performing schools in the country based on the results of the latest Real Estate Appraisers Licensure Examination.
The PRC said that NEU garnered 100 percent passing rate in the September 2021 Real Estate Appraiser Licensure Examination, along with another school, the Cronasia Foundation College Inc., in General Santos City.
All the examinees of both schools passed the licensure exams, and each also had a graduate that made it to the top 10.
The NEU posted a 100 percent passing rate for five of its examinees, with one of them, Lilia Salazar, placing 8th in the said licensure examinations, with a score of 84.5 percent.
The Cronasia Foundation College Inc., also garnered a 100 percent passing rate with seven examinees, one of whom, Jed Cua Romero, placing fifth with a score of 86 percent.
Because of this, both New Era University and Cronasia Foundation College Inc., shared rank 1 in the PRC's list of top perfoming schools for the September 2021 Real Estate Appraisers Licensure Exam (REALE).
The other top performing schools are Trinity University Of Asia (Trinity-QC) with a rating of 85.71 percent; Southway College Of Technology with a rating of 84 percent; Emilio Aguinaldo College Dasmariñas with a rating of 83.33 percent; Gardner College Diliman, Inc. with a rating of 82.35 percent; and University Of Mindanao – Davao City with a rating of 80%.
A graduate from University of Cebu, Juliefe Cuenca, topped the licensure exams with a score of 90.5 percent.
-Performance in other licensure exams-
The New Era University said that for three consecutive years, from 2019 to 2021, its College of Medicine had also achieved a 100 percent passing rate in the Physician Licensure Examination.
The six graduates of the NEU's College of Medicine all passed the PLE last March 2021.
In 2019, the NEU also posted 100 percent passing rate for the Respiratory Therapist Licensure Exams.
The NEU College of Nursing has also been listed as one of the top performing schools for nursing, having consistently achieved a 100 percent passing rate from 2015 to 2019 in the Philippine Nursing Licensure Examinations (PNLE).
NEU President Dr. Nilo Rosas said that these achievements were all because of God's help.
(Eagle News Service)


By law, you can't leave the hospital with your new baby unless your infant car seat is properly installed.
The world of baby gear is vast with thousands and thousands of products in every style, color and category you can imagine. If you're expecting your first baby, you've probably already started shopping, and oh boy, is it fun!
Buying baby gear isn't always a splurge, because there are necessities every mom needs like car seats and strollers. I remember the infant car seat we had for my first son, because I got it as a baby shower gift. It was a beautiful steel blue carrier and awell-known brand name. I was overjoyed!
My husband picked out a different car seat carrier (red plaid) to put in his car. When we started the installation process, we fumbled around with the bases and discovered the blue beauty fit much better in his SUV than it did in my car. I was so bummed. Lesson learned!
Infant car seats are available in two styles with one main difference. A convertible car seat can be turned around to face forward after baby reaches age/weight/height requirements, but it stays in the car. An infant carrier clicks in and out of a base, so you can carry baby without taking her in and out of the car seat.
Your newborn will spend a lot of comfy, cozy time in her infant car seat and chances are if she's sleeping, you won't want to wake her up by moving her. That's why most moms agree that an infant carrier is the best choice. Plus, infant carriers easily snap into many stroller frames.
When it comes to infant car seats, they may all look similar, but slight variations can make a big difference. For example, depending on the style of the car seat, it can be too big or too small for your back seat. You certainly don't want to discover that after you've purchased it.
If you buy an infant carrier or travel system, you might want to buy an extra infant car seat base, so you can easily transfer the car seat to other vehicles. Again, make sure the base fits in all of the vehicles you'll be using.
Another item you may want to consider is a car seat mat to protect your car's interior. These mats fit securely and safely under the car seat base. When your baby gets bigger, you'll soon discover just how messy car seats can get.
Before baby arrives make sure your infant car seat is installed properly. The hospital won't let you take your sweet bundle of joy home without it. You can guesstimate how to adjust the straps, but you won't know for sure until your baby is in the car seat.
It's hard not to be in awe of today's luxury travel systems. Prams, joggers, reversible and reclining seats, oh my! High-end strollers are beautiful, innovative and sophisticated, but you might not need all of those bells and whistles right away.
If you want to invest in a nice stroller or travel system, make sure you test out a few first. Ask other moms for recommendations, because real world feedback is helpful. Plus, moms who live in your community may know the best place to shop for strollers–retail, consignment or thrift!
If your hubby is shopping with you, he should test them out too. You won't really know which stroller is comfortable for both of you unless you take it for a spin to test handle height. Many strollers have adjustable height handles, but height varies by brand from 40 to 46 inches tall.
For the first few months you may want to use a stroller frame instead. Stroller frames are inexpensive, lightweight and easy to fold and unfold. You simply pop the infant car seat in and out of it. They also have features like cup holders and trays that come in handy.
Do you have tips for moms who are shopping car seat and strollers? Let us know in the Little Remedies® Facebook page!


Cargill Business Services, a unit of Cargill India, attempted to enter Limca Book of records by making 27.707 paper bags in the record time of 40 minutes. This was a joint initiative of Cargill Business Services and United way Bengaluru, an NGO. Cargill provides numerous food, industrial and agricultural products and services to the world. Recently, the company organised a mass volunteering event across the world for the duration of 3 months starting for April, Earth day to June, Environmental Day. These events involved 8,316 employees in 39 countries logged over 11,000 volunteer hour.
The event in Bangalore was initiated with an intention of curbing plastic pollution. The bags which were made via used papers were distributed to the local vendors in the city with the help of the NGO United way.
Manish Michael, CEO, United Way of Bengaluru, also addressed the audience. He said, "Plastic pollution has a serious impact on environment. This is a great initiative taken by Cargill which is the need of the hour that will help in spreading awareness towards more eco-friendly replacements. We are glad to reach out to 2,000 street vendors for this initiative and help inculcate use of bags made from used paper for themselves and their customers as part of this initiative".
Cargill has been taking numerous initiatives towards a better environment. Cargill India employees were recently involved in creating Miyawaki forest, a technique recognised to grow saplings 10 times faster than the usual. In another lead, more than 100 Cargill employees along with the NGO Say Tree, created seed balls to contribute towards afforestation. In India, in the span of 5 years, Cargill's movements have impacted over 3.2 million lives.


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text:
Chernobyl Smile
The holiday of Joy in Borghetto
The House of joy
Internats
Serghej
Spread the project
Chernobyl@School
The Chernobyl nuclear disaster took place on 26 April 1986 at 1:23 at night at the Lenin nuclear power plant in northern Ukraine, 3 km from the city of Pryp'jat 'and 18 km from Černobyl' and only 16 km south of the border with Belarus.
The causes were variously indicated in serious failings by the personnel, both technical and managerial, in problems related to the structure and design of the plant itself and in its incorrect economic and administrative management. During a "safety" test, the personnel was responsible for the violation of various safety and common sense rules, leading to a sudden and uncontrolled increase in the power (and therefore the temperature) of the reactor core n. 4 of the power plant. The refrigeration water was split into hydrogen and oxygen at such high pressures as to cause the reactor cooling system pipes to break. The contact of the hydrogen and the incandescent graphite of the control bars with the air, in turn, triggered a very strong explosion, which caused the reactor to uncover and consequently caused a huge fire.
A cloud of radioactive material escaped from the reactor and fell on large areas around the plant, contaminating them heavily and making the evacuation of about 336,000 people necessary. Radioactive clouds also reached eastern Europe, Finland and Scandinavia with levels of minor contamination. In the following days it also touched Italy, France, Germany, Switzerland, Austria and the Balkans, up to portions of the east coast of North America.
Even today those heavily contaminated areas suffer from that serious accident. Thousands of children were born deformed as a result of the nuclear disaster, are the children who still populate a boundless army of orphanages in Belarus.


If you're going to be in the area of Worcester, Pa., then you might want to check out the annual music and horror convention Rock & Shock.
Guests this year include Shawnee Smith (Saw I, II & III), Tony Todd (Candyman), and several members of Rob Zombie's Halloween cast, among others. For more information, visit www.rockandshock.com.


DriverMax available for more than 2,300,000 devices. DriverMax support drivers: 1) Windows system drivers – Motherboards, Network Adapters, Video Adapters, USB Devices , Modems, CD and DVD Drives, Sound Cards, and more. 2) Mouse from manufacturers like 3Com, Adaptec, AMD, Atheros, Cisnet , Conexant, CXT, D-Link, Hauppauge, Hp, Intel , Leadtek , Lexmark , Logitech , Maxtor , MPC , Nikon , NVidia , Olympus, Philips, RealTek, Saitek, Sapphire , Sharp , Sony Ericcson , Toshiba , Western Digital, and more.
Enter the name and email address, and then click "Send" button.
You will receive an email from DriverMax containing with the license serial key. Note: If an email does not receive within five minutes, please check SPAM folder.
Download and register DriverMax to full version with license serial key receive. Note: There is no free technical support and no updates.


text:
package org.example;

import org.eclipse.jetty.server.Server;
import org.eclipse.jetty.servlet.DefaultServlet;
import org.eclipse.jetty.servlet.ServletContextHandler;
import org.eclipse.jetty.servlet.ServletHolder;

import com.sun.jersey.spi.container.servlet.ServletContainer;

public class HelloWorld {
	public static void main(String[] args) throws Exception {

		Server server = new Server(8080);

		ServletContextHandler context = new ServletContextHandler(
				ServletContextHandler.NO_SESSIONS);
		context.setContextPath("/");
		server.setHandler(context);

		ServletHolder jerseyServlet = context.addServlet(
				ServletContainer.class, "/webapi/*");
		jerseyServlet.setInitOrder(1);
		jerseyServlet.setInitParameter(
				"com.sun.jersey.config.property.packages", "tabloide.web");

		ServletHolder staticServlet = context.addServlet(DefaultServlet.class,
				"/*");
		staticServlet.setInitParameter("resourceBase", "src/main/java");
		staticServlet.setInitParameter("pathInfoOnly", "true");

		try {
			server.start();
			server.join();
		} catch (Throwable t) {
			t.printStackTrace(System.err);
		}
	}
}

redpajama_set_name: RedPajamaGithub


NewSPORT is holding a four day Water Polo camp for boys and girls in Years 3 to 6. Our aim is to provide an active holiday environment with an appropriate balance between 'Water Polo fundamentals' and 'Water Polo fun'. We hope to cover both individual skills and team concepts during the course of the camp.
The camp will be lead by experienced Newington College Water Polo coaches.
Bring: Morning Tea , Water Polo Training Gear, Googles, Water Bottle, Swimmers and towel.


text:
How to choose a UTV: Buying the right Side-by-Side
Dirt Portal Staff
If you are in the market for a Side-by-Side and begin looking at all the available models, the choice for what UTV to buy can be daunting.
At the time of writing this, there are 15 companies that manufacture UTVs/Side-by-Sides. Each company builds between 1-4 different models and some models have multiple trim levels.
As you can see in the manufacture and model list below, there are a lot of choices when it comes to buying a UTV. Undoubtedly most enthusiasts have heard of Yamaha, Polaris, Honda, Kawasaki, Can-Am and Arctic Cat but there are other companies making Side-by-Sides too.
Arctic Cat / Textron
ZForce
UForce
X-F
RTV400/RTV500
RTV-X900
RTV-X1120
RTV-X1100C
RTV-XG850 Sidekick
Hinsun
Crewcab Series
Retreiver
Pitster Pro
SRU170RS
Tracker Offroad
800SX Crew
SVX1000
XTR1000
When looking to buy a Side-by-Side there are a lot of options that make the buying process full of choices. These include choosing a brand, engine size, new vs used, trim levels and more.
Below I will detail some of the choices available when choosing a UTV to help eliminate the confusion that comes with buying your new vehicle.
Utility, Recreation, Sport or High Performance Models
Sport & High Performance
Turbo or Non-Turbo
How many seats do you need?
Popular Brands vs Lesser Known Brands
Sequential Transmission
Factory Accessories and Creature Comforts
What to look for in a used UTV
Overall condition
The purpose of the UTV is the biggest consideration when choosing what model to buy. Will it be used on the farm or job site as a tool to haul materials and tow trailers around? Or are you looking for the fastest, most aggressively styled dune shredding Side-by-Side available? Maybe something in between?
Deciding what purpose the UTV will be used for most is the first choice in picking the right vehicle. Most UTVs are good at a variety of uses but most have specific purposes they excel at.
Utility UTVs are made primarily for work use. That's not say they can't be used for play but they aren't built to be the fastest or best cornering vehicles. Utility models comes with a bed in the back for carrying loads of tools or farm and construction building materials. These models also come with a trailer hitch for towing small trailers.
The Kawasaki Mule and Yamaha Viking fall into this category. While they can certainly be used to have fun, their main purpose is functionality and utility, being used more as a tool than strictly for recreation.
Recreation type Side-by-Sides fall in the middle between Utility and Sport and Performance models. They are more slightly more focused on performance than utility function but are not as performance focused as Sport and High Performance models.
These UTVs are faster and have better suspension than Utility models. But they still come with a cargo bed like the Utility Side-by-Sides.
They are great for tight forest trails making them perfect for camping excursions and having fun in the mountains. When you want a vehicle can be used for both work and play Recreational models are the obvious choice.
SEE ALSO: 5 of Our Favorite SxS Accessories
Models included in this category include the Polaris General and Honda Pioneer among many others.
The Sport and High Performance category is where big horsepower and high tech Fox Racing Suspension is the name of the game. These vehicles are faster, wider and more expensive than Utility or Recreation models.
Seeming endless suspension travel, high revving high-output engines and aggressive tires set this category of Side-by-Sides apart. When your goal is going very fast and handling jumps with easy these are the models you want.
The drawback to these machines is that they aren't well suited for carrying heavy loads around the farm or venturing through narrow trails. Cargo beds don't come on these vehicles, just a small storage area in the rear.
They do have low range so they can crawl over technical terrain and through tight areas but their wider stance can make it difficult.
If you've decided to get a High Performance UVT an important decision is choosing a turbo or non-turbo model. A turbocharged UTV will have much more power and accelerate quicker than a non-turbo.
The downside of a having a turbo is the increased complexity of the engine. It's one more thing to worry about failing and maintaining as the engine get more miles on it.
Brand new Side-by-Sides don't have a problem with failing turbos but it's something to be aware of when buying used.
The advantage of a turbo is the amazing acceleration and the feeling of never-ending power. Ride a RZR XP 1000 in the sand dunes then go ride in a RZR XP Turbo and you will be surprised how much better the turbo model pulls hills.
The size of the engine will effect how much power a UTV has. A larger engine will have more power than a smaller one but the larger engine will cost more.
If you want lightening fast acceleration or plan on hauling passengers and lots of gear go for a 900-1000cc engine. The extra power will be welcomed. The same goes for riding in the sand dunes and deep mud, aim for 900cc or larger.
For farm work, less aggressive trail riding or general outdoor exploration 800cc and smaller engines are a great choice.
Side-by-Sides come with multiple passenger options. You can get them with the following seating configurations:
1 Seater – Driver only, no passengers
2 Seater – Driver and 1 passenger, seated side by side
3 Seater – Driver and 2 passengers, seated side by side
4 Seater – Driver and 3 passengers, 2 rows of 2
Determining the number of seats need is based on how many passengers will be riding with the driver. Something to consider when making this choice are the physical dimensions and weight. A Side-by-Side that carries more passengers will be larger and heavier than one made for fewer passengers.
Three and six seat models are generally utility oriented models. Ideal for farms and job sites these models are great for carrying people, tools and materials. Specific models include the Polaris Ranger Crew, Yamaha Viking VI, and Can-Am Defender Max.
One, two and four seat UTVs can be utility or sport / performance oriented.
Another consideration when purchasing a UTV is the brand. Should you go with popular brands like Polaris or Yamaha that have been in the power-sports industry for decades? What about a brand like CFMoto or Hinsun? These names may not be be as well known in the ATV and UTV market but still offer numerous models.
Does that mean they are not as good? Honestly I have never owned one so I can't answer that. However, if I were in the market for a less expensive UTV or looking for an entry into the sport I would give them serious consideration.
Before buying one I would find out what kind of warranty these manufacturers offer and the availability of replacement parts.
How does the warranty compare to other companies?
How available are the parts? Can you buy them from Motosport.com, RockMountainATV/MC.com or any other large online retailer. Or are they only available through the manufacturer.
How does the price of these parts compare to other UTV companies?
Talking to other owners is also a great way to get feedback from someone what has owned the brand and model you are looking at. If they would buy their Side-by-Side again that's a good sign.
Side-by-Sides comes have several options when it comes to the transmission. The type of transmission might not be a big consideration but it will dictate how much interaction the driver has with the vehicle.
The three main options are the CVT (continuously variable transmission), DCT (dual clutch transmission) and the sequential transmission.
CVT transmissions are by far the most popular option and are found in most Side-by-Sides. These use a belt and require no manual shifting from the driver. As you step on the accelerator pedal the engine speeds up and the primary and second clutches adjust accordingly via the belt connecting them.
The only shifting the driver does is between high, low, park, reverse and neutral. There is no clutch pedal or shifting gears once you put the transmission into high or low gear. To the driver a CVT works similarly to an automatic transmission in a car.
Practically every Side-by-Side uses a CVT except the Honda Talon and Pioneer and the Yamaha YXZ.
The sequential transmission found in the Yamaha YXZ is similar to that of a motorcycle transmission. It has a gear shift lever that shifts down when pushed forward and shifts up when pulled back. It uses a clutch pedal like works similar to that of a car.
Yamaha also offers the YXZ with a Sport Shift transmission. It doesn't have a clutch pedal and uses paddle shifters behind the steering wheel. The Sport Shift transmission allows for full throttle shifts (no letting off the gas) and automatic downshifting that engages when the vehicle comes to a stop without downshifting with the paddles.
Honda uses a DCT (dual clutch transmission) in the Talon and Pioneer. It's a sophisticated, modern transmission similar to that found in sports cars.
Honda's transmission has 3 modes: 2 fully automatic modes, Drive and Sport which automatically shifts the transmission as the UTV accelerates and decelerates. Then there is Manual mode that allows the driver to change manually gears using steering wheel mounted paddle shifters.
As UTVs become more common and are used for a wider variety or purposes factory accessories and creature comforts become increasingly common. No longer are the days of a UTV being just a sparsely equipped farm tool.
Below are some of the factory options and accessories available when buying a new Side-by-Side.
Fully Enclosed Cabs
Bumpers and more.
The decision to buy new or used usually depends how much you are willing to spend. Used Side-by-Sides can be had for much less than a brand new one. This is beneficial when getting into the sport and deciding if you like it or not.
A new Side-by-Side will come with a warranty and has the advantage of having never been used before. There are no surprises as far as maintenance or damage goes. You know the entire history of the machine because no one else has used it. The downside to this is obviously cost, a new Side-by-Side is more expensive than used, but can be financed.
Whereas used UTVs cost less, there is no guarantee what you are getting. Unless buying used from a dealer or close friend, maintenance or damage is uncertain. It's not always visible if a vehicle was abused or has internal damage to the engine or transmission. Buying used can be somewhat of a gamble. That's why it's important to know what to look for when buying used.
For someone new to the sport if can be difficult to know what to look for when buying a used UTV. Unless you are familiar with certain models you don't know what potential problems to look for. The following points will give you an general idea of what to pay attention to and look out for.
First take a look at the general condition. If the UTV has mud caked everywhere and the body panels have cracks that is a potential sign the vehicle was driven hard. To be fair, these machines are meant to be driven and not just sit in a garage. But if it's dirty and damaged it was probably abused.
Which brings up the next point, maintenance. Ask the owner what maintenance was done and when. Ask to inspect the air filter and take a look around the engine and differentials for oil leaks. Check the dipstick and look at the oil. The oil should be somewhat clean, not black or dirty.
Check for coolant leaks around the radiator and verify it is at the proper level.
Check the grease fittings. They should look like they have been used somewhat recently. You can tell if they have been used by looking for fresh grease on them or if it looks like a grease gun has been attached to the fittings.
Inspect the suspension components by looking for loose nuts and bolts. Look closely at the shocks for damage. Keep an eye out from hairline cracks in the suspension components, frame and roll cage.
If it has aftermarket parts what is the installation quality? Does it look like it was installed by someone that knew what they were doing or is it a hack job? Improperly installed parts can turn into problems.
The most important way to get a feel for a used UTV is to take it for a test drive. Listen for abnormal sounds (grinding, whining, clunking). Make sure the brakes work, it handles well and the engine is smooth. A test drive should alert you of any major problems. If you can, try to test the vehicle in as many driving situations as possible.
There are numerous choices when it comes to buying a UTV. With so many options out there it can be difficult to make a decision. Choosing the right model is best done by determining how the vehicle will be used and what characteristics it needs.
By doing this you can be confident that your decision is the right one and you have chosen the best UTV for your needs.
Tags: Buyer's Guide
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