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Category: Estrogen (GPR30) Receptors
Following injury, the resulting scar that forms usually displays pigmentation defects, of either hypo or hyperpigmentation in scar area (Engrav et al
Following injury, the resulting scar that forms usually displays pigmentation defects, of either hypo or hyperpigmentation in scar area (Engrav et al., 2007), thus increasing the detrimental risks associated with exposure to the sun in addition to the cosmetic or psychological challenges to the patient. variants. Introduction Stem cells self-renew, and simultaneously generate differentiated progeny for normal A 77-01 tissue homeostasis and regeneration in response to injury or diseases. The cycling nature of the hair follicle and the defined stem cell populace that occupies this organ has provided a means to investigate mechanisms that regulate adult stem cells. Pigmented hair regeneration requires epithelial stem cells (EpSCs) and McSCs in the hair follicle (Cotsarelis et al., 1990; Myung et al., 2013; Nishimura et al., 2002), which undergo hair cycle phases of growth (anagen), regression (catagen) and rest (telogen) (Dry, 1926; Muller-Rover et al., 2001). McSCs reside in the lower permanent portion of the hair follicle throughout the hair cycle. During the telogen phase, bulge/sHG area represents the lower permanent portion of the follicle in which McSCs are maintained in a quiescent state. McSCs become activated at anagen onset to proliferate and give rise to differentiated progeny. As anagen ensues, differentiated progeny migrate downwards to the bulb compartment where they produce pigment for the hair. This segregation allows ones to histochemically identify McSCs with universal marker of melanocytes such as (Trp2), based on the anatomically defined location of the niche in mice. During catagen, differentiated melanocytes in the bulb undergo apoptosis, while McSCs survive. Accordingly, telogen follicles contain only McSCs that are re-activated in the next hair cycle. The activation state of McSCs is usually governed by the niche (Nishimura et al., 2002), which is composed of EpSCs of the hair follicle (Rabbani et al., 2011; Tanimura et al., 2011). Thus far, only a handful of signals that regulate McSCs have been identified, including extrinsic signals, such as TGFB and Wnts, which are provided by the epithelial niche (Myung et al., 2013; Nishimura et al., 2010; Rabbani et al., 2011). Wnt signaling induces activation of EpSCs to drive epithelial regeneration, while coordinately inducing McSCs to proliferate Rabbit Polyclonal to ELOA1 and differentiate to pigment regenerating hair follicle A 77-01 (Rabbani A 77-01 et al., 2011). In addition to providing pigment to the hair follicle, McSCs can also generate epidermal melanocytes in response to wounding (Chou et al., 2013; Nishimura, 2011). However, the signaling pathways that regulate differentiation and establishment of epidermal melanocytes from McSCs are only beginning to emerge, including Wnt and Mc1R signaling (Chou et al., 2013; Yamada et al., 2013). It is poorly comprehended how McSCs are maintained to ensure an adequate supply of stem cells for homeostasis and regeneration and how they are primed to respond to injury. Addressing these issues would allow us to identify therapeutic targets to treat pigmentation disorders. Despite the well-known functions for Endothelin receptor B (EdnrB) and its ligands, Endothelin (Edn1, 2 and 3), in melanocytes during embryogenesis (Giller et al., 1997; Matsushima et al., 2002; Saldana-Caboverde and Kos, 2010), their function in adult melanocytes during normal homeostasis and regeneration has not been resolved. During embryogenesis, EdnrB mutations in mice give rise to pigmentation defects and are linked to A 77-01 Waardenberg syndrome that accompanies hypopigmentation (Attie et al., 1995; Baynash et al., 1994; Edery et al., 1996). Binding of Edns to EdnrB results in phosphorylation of cAMP response element binding protein (CREB) and microphthalmia-associated transcription factor (MITF), leading to the transcription of target genes, including MITF, the transcription factor that is pivotal to the expression of numerous pigment enzymes and differentiation factors(Levy et al., 2006; Nakajima et al., 2011; Sato-Jin et al., 2008). Recently, it was shown that Edn1 is usually secreted from neighboring EpSCs at anagen onset, whereas Edn2 is usually upregulated in EpSCs upon A 77-01 ablation of the transcription factor nuclear factor I/B (NFIB) (Chang et al., 2013; Rabbani et al., 2011). Additionally, previous studies have exhibited the expression of EdnrB in McSCs (Rabbani et al., 2011)(Fig S1). However, the function of Edns/EdnrB signaling in McSCs during hair cycle has not been characterized by gain or loss of function approaches. Moreover, how it collaborates with other pathways is usually incompletely comprehended. In this study, we analyzed the role of Edn/EdnrB signaling in adult McSCs, using a combination of loss and gain of function genetic mouse models. We found that Edn/EdnrB is critical in melanocytes for hair pigmentation during homeostasis and the generation of epidermal melanocytes following wounding. Epithelial Edn1 overexpression is sufficient to establish epidermal melanocytes under normal homeostatic conditions. Moreover, it is sufficient to overcome the effects of loss of.
Another characteristic feature is that loop 108C129, which contains one of the eukaryotic inserts, was disordered
Another characteristic feature is that loop 108C129, which contains one of the eukaryotic inserts, was disordered. a combined (noncompetitive) inhibitor vs dUMP. In contrast, vs methylenetrahydrofolate at concentrations lower than 0.25 M PDPA is an uncompetitive inhibitor, while at PDPA concentrations higher than 1 M the inhibiton is noncompetive, as expected. In the concentrations related to uncompetitive inhibition, PDPA shows positive cooperativity with an antifolate inhibitor, Butoconazole ZD9331, which binds to the active conformer. PDPA binding prospects to the formation of hTS tetramers, but not higher oligomers. These data are consistent with Butoconazole a model in which hTS exists preferably as an asymmetric dimer with one subunit in the active conformation of loop 181C197 and the additional in the inactive conformation. Thymidylate synthase (TS) catalyzes the reaction in which the nucleotide deoxyuridylate (dUMP) is definitely reductively methylated from the folate co-substrate 5,10-methylenetetrahydrofolate (CH2H4folate) to form thymidylate (TMP) and dihydrofolate (1). Substrates are bound in an ordered manner, with dUMP binding in the active site prior to CH2H4PteGlu. A cysteine residue (Cys195 in hTS) in the active site attacks the 6-position of the pyrimidine base of the nucleotide, resulting in the formation of a covalent relationship between TS and the nucleotide and activating the 5-position of the nucleotide for subsequent covalent-bond formation with the C-11 substituent of CH2H4folate (examined in 2C4). The enzyme is the sole source of synthesized thymidylate and its inhibition prospects to apoptosis of rapidly dividing cells such as cancer cells, an effect sometimes referred to as thymineless death (5). This trend is definitely exploited in restorative protocols utilizing TS inhibitors, such as raltitrexed, pemetrexed or pro-drugs such as 5-fluorouracil and 5-fluorodeoxyuridine that are metabolized to TS inhibitors. The inhibitors are either nucleotide analogs such as 5-fluorodeoxyuridylate (FdUMP) or folate analogues that are collectively referred to as antifolates. The effectiveness of TS-directed chemotherapy is definitely often limited by growing resistance, which usually arises from an increase in intracellular TS protein levels by a factor of 2C4 (examined in 6). Two major mechanisms leading to increased hTS levels have been proposed. In one mechanism, the intracellular turnover of hTS protein is definitely decreased upon formation of inhibitory complexes with medicines (6, 7). The additional mechanism is related to hTS protein binding to its own mRNA and inhibiting its translation. The formation of inhibitory complexes by hTS competes with mRNA binding and thus reduces the translational repression of hTS (examined in 8, 9). This effect is definitely reversed in some additional species (10). Human Butoconazole being TS differs from bacterial TS in three areas: the N-terminus of hTS is definitely prolonged by 28C29 residues and two insertions of 12 and eight residues are present at positions 117 and 146 of hTS, respectively (2). The crystal structure of hTS has been initially decided using crystals obtained at high ammonium sulfate concentrations (11, 12). At these conditions the active-site loop 181C197 is in a conformation different from that observed in bacterial TS. Since this conformation locations Cys195, a residue important for catalytic activity, outside the active site, the conformer must be inactive. Another characteristic feature is definitely that loop 108C129, which consists of one of the eukaryotic inserts, was disordered. There were four sulfate ions bound per subunit, which appeared to stabilize the inactive conformer. Studies of a truncated version of hTS (13) and an inhibitory complex of hTS with dUMP and IgG2b Isotype Control antibody (PE) raltitrexed (14) yielded high-resolution constructions of hTS with loop 181C197 in the active conformation. In these constructions, identified at low salt concentration, loop 108C129 was ordered. Later on studies showed that also at low salt, 30 mM ammonium sulfate, hTS adopts the inactive conformation with loop 108C129 disordered (15). Intrinsic fluorescence studies of hTS showed that in remedy there is equilibrium between the active and inactive conformers and that the presence of phosphate or sulfate ions drives the equilibrium for the inactive conformation, while dUMP, a substrate, drives it for the active conformation (12). It was proposed the stabilization of the inactive conformation may be used to accomplish hTS inhibition (11) and was argued that it may yield therapeutic results superior to those of classical active-site-directed inhibitors as it may not lead to increased levels of TS (12; 16). The enzyme is definitely a dimer of two identical subunits, which generate an asymmetry upon substrate/ligand binding (17). The bad cooperativity between subunits strongly depends on inhibitors (18) and the source of the enzyme. Among many structural studies of inhibitory.
Indeed, ITGA5 has been associated with lung metastasis in animal models of breast cancer [14, 15]
Indeed, ITGA5 has been associated with lung metastasis in animal models of breast cancer [14, 15]. metastasis or tumorigenesis, and blunted cancer-associated bone destruction. ITGA5 was not only expressed by tumor cells but also osteoclasts. In this respect, M200 decreased human osteoclast-mediated bone resorption in vitro. Overall, this study identifies ITGA5 as a mediator of breast-to-bone metastasis and raises the possibility that volociximab/M200 could be Aminophylline repurposed for the treatment of ITGA5-positive breast cancer patients with bone metastases. expression in primary breast tumors is an independent prognostic factor for bone relapse. ITGA5 heterodimerizes with integrin beta1 to form the fibronectin receptor 51 [9]. In breast cancer, ITGA5 mediates tumor cell adhesion, PRKACA extracellular matrix-guided directional migration along fibronectin, and tumor cell survival in vitro [9C13]. ITGA5 also mediates lung metastasis in animal models of breast cancer [14, 15]. Additionally, a synthetic peptide inhibitor Aminophylline derived from the synergy region of fibronectin that binds to 51 and v3 integrins (ATN-161, also called PHSCN) reduces both MDA-MB-231 breast cancer bone metastasis formation and skeletal tumor outgrowth [14, 16]. However, ATN-161 interacts with v3 [16], and the treatment of tumor-bearing animals with a specific nonpeptide antagonist of v3 (PSK 1404) also inhibits bone metastasis formation [17], suggesting that the inhibitory effect of ATN-161 on bone metastasis formation was mediated through the therapeutic targeting of v3. Besides ATN-161, a humanized IgG4 monoclonal antibody against 51, known as M200 (volociximab), was developed as an antiangiogenic agent for the treatment of solid tumors and age-related macular degeneration [18, 19]. A phase I study conducted in 22 patients with advanced stage solid tumors showed that the pharmaco-toxicologic profile of M200 is safe, and preliminary evidence of antitumor activity was reported in one patient with renal cell carcinoma [18]. Clinical trials also evaluated its safety in Aminophylline the treatment of ovarian cancer and non-small cell lung cancer, as a single agent or in combination with chemotherapy [20, 21]. Here, we provide evidence that ITGA5 is a mediator of bone metastasis and a potential therapeutic target for bone metastasis treatment. Using genetic overexpression or silencing strategies, we show that ITGA5 in breast cancer cells mediates metastatic tumor cell colonization of the bone marrow and promotes formation of osteolytic lesions in vivo. Furthermore, we show that M200 could be effective in the treatment of breast cancer patients with osteolytic bone metastases by targeting both tumor cells and osteoclasts, the latter being bone-resorbing cells that mediate cancer-induced bone destruction. Results ITGA5 is a bone metastasis-associated gene in breast cancer We compared the transcriptomic profile of 21 bone metastases with that of 59 metastases from other distant organs. This analysis identified 246 genes (gene set #1) that were expressed at higher levels in bone metastases compared to non-bone metastases (Fig. ?(Fig.1A1A and Table S1). In parallel, the analysis of 855 radically resected primary breast tumors with known location of the first distant metastasis led to 146 genes (gene set #2) that were significantly upregulated in primary tumors from patients who first relapsed in bone, compared to patients who first relapsed at non-bone metastatic sites or did not relapse after 200 months follow-up (Fig. ?(Fig.1B1B and Table S1). Eight genes were common to gene sets #1 and #2: EGF-containing fibulin-like extracellular matrix protein 2 ((cell migration-inducing and hyaluronan-binding protein), microfibrillar-associated protein 5 (EGF-containing fibulin-like extracellular matrix protein 2, integrin alpha5, cell Aminophylline migration-inducing and hyaluronan-binding protein (CEMIP), microfibrillar-associated protein 5, plexin Aminophylline domain-containing protein 1, SPARC (osteonectin), Cwcv and kazal-like domains proteoglycan 1, T-cell immune regulator 1, transforming growth factor beta1-induced transcript 1. D mRNA expression levels in breast cancer metastases. Data are expressed as mean??SEM. E KaplanCMeier estimates for rates of bone metastasis-free survival of breast cancer patients (expression levels..
pDCexos as a result represent a new addition in our arsenal of DC-based malignancy vaccines that would potentially combine the advantage of pDCs and DCexos
pDCexos as a result represent a new addition in our arsenal of DC-based malignancy vaccines that would potentially combine the advantage of pDCs and DCexos. Keywords: dendritic cells, vaccines, plasmacytoid DCs, exosomes, DC-targeted vaccines 1. failed to generate antigen-specific T cell reactions. Another fascinating development is the use of naturally circulating DCs instead of in vitro cultured DCs, as clinical tests with both human being blood cDC2s (type 2 standard DCs) and plasmacytoid DCs (pDCs) have shown promising results. pDC vaccines were particularly motivating, especially in light of encouraging data from a recent clinical trial using a human being pDC cell collection, despite pDCs becoming regarded as tolerogenic and playing a suppressive part in tumors. However, how pDCs generate anti-tumor CD8 T cell immunity remains poorly recognized, therefore hindering their medical advance. Using a pDC-targeted vaccine model, we have recently reported that while pDC-targeted vaccines led to strong cross-priming and durable CD8 T cell immunity, cross-presenting pDCs required cDCs to accomplish cross-priming in vivo by transferring antigens to cDCs. Antigen transfer from pDCs to bystander cDCs was mediated by pDC-derived exosomes (pDCexos), which similarly required cDCs for cross-priming of antigen-specific CD8 T cells. pDCexos therefore represent a new addition in our arsenal of DC-based malignancy vaccines that would potentially combine the advantage of pDCs and DCexos. Keywords: dendritic cells, vaccines, plasmacytoid DCs, exosomes, DC-targeted vaccines 1. Intro As the professional antigen showing cells (APCs), dendritic cells (DCs) play a critical part in the initiation and rules of innate and adaptive immune responses, and have the unique ability to activate (perfect) both na?ve CD4 and CD8 T cells [1]. Cross-priming, a process in which DCs activate CD8 T cells by cross-presenting exogenous antigens onto MHC class I molecules [2,3], takes on a critical part in generating CD8 T cell immunity against cancers and viruses, upon vaccination, as well as with the induction of CD8 T cell tolerance (cross-tolerance) [4,5,6,7]. Exploiting their ability to potentiate sponsor effector and memory space CD8 T cell reactions critical for anti-tumor immunity, DC vaccines have emerged as one of the leading strategies for malignancy immunotherapy [8,9,10,11]. Of notice, vaccines with additional APCs including B cells and macrophages have also been shown to generate T cell-mediated anti-tumor immunity [12]. Indeed, B cell vaccines represent a stylish alternative to DC vaccines, as B cell function in T cell activation offers been shown to be resistant to immunosuppressive cytokines including IL-10, TGF- and VEGF often present in the tumor microenvironment [12,13]. However, vaccines with these additional APCs are under-studied, and DCs remain the mind-boggling cell of choice for cell-based vaccines for malignancy immunotherapy [14]. DCs comprise heterogenous populations including standard DCs (cDCs), LY2603618 (IC-83) plasmacytoid DCs (pDCs) and monocyte-derived DCs (MoDCs) [11,15,16]. DC vaccines, LY2603618 (IC-83) of which the vast majority use monocyte-derived DCs generated in vitro, are largely unsuccessful, only achieving objective immune reactions in 5C15% of individuals. Sipuleucel-T, which comprise blood cells enriched for antigen-presenting cells (APCs) including DCs, remains the only FDA (Food and Drug Administration)-authorized DC malignancy vaccine in over 10 years [17]. Despite mainly disappointing medical tests, the promising results from DC vaccine medical tests using neoantigens present an exciting fresh development on DC vaccines for malignancy immunotherapies [18,19,20]. Recent discovery within the crucial part of cDC1s (type 1 standard DCs) in cross-priming tumor antigen-specific CD8 T cells and in determining the effectiveness of malignancy immunotherapies [21,22,23,24,25], further highlighted the importance of the development and refinement of DC-based vaccines either as monotherapy or combinational immunotherapies. You will find two major hurdles of the success of DC vaccines: tumor-mediated immunosuppression and the practical limitations LY2603618 (IC-83) of the commonly used in vitro differentiated DCs [10,11]. As inert vesicles, DC-derived exosomes (DCexos) Rabbit polyclonal to AKT1 are resistant to rules by tumor-related factors compared to DCs. Consequently, vaccines with DCexos might represent a new type of DC-based vaccines that could conquer tumor-mediated immunosuppression [26]. In vivo DC-targeted vaccines and the use LY2603618 (IC-83) of naturally circulating blood DCs also present encouraging alternatives to in vitro-differentiated DCs used in the majority of clinical tests [27]. The encouraging clinical tests of pDCs, including a recent clinical trial using a human being pDC cell collection, and the potential of combining pDCs with cDCs, support further development of pDC-based malignancy vaccines immunity [28,29,30]. The generation of previously unreported pDC-derived exosomes (pDCexos) [31] present an exciting new addition in the arsenal of DC-based vaccines, as vaccines with pDCexos have the potential to combine the advantages of both pDC and DCexo vaccines..
Programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) blockade is really a appealing therapy for various cancer types, but many individuals are resistant still
Programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) blockade is really a appealing therapy for various cancer types, but many individuals are resistant still. PD-L1 and MHC-I decrease on tumor level of resistance and cells to PD-L1 blockade, and thus shouldn't HQL-79 be utilized as an individual predictive marker for anti-PD-1/PD-L1 cancers therapy. and genes had been identified in a variety HQL-79 of sorts of individual malignancies with a variety of 6%C12% and 5%C17%, respectively. As these mutations could be responsible for having less acquired PD-L1 appearance, they could predict sufferers who are unlikely to take advantage of the anti-PD-1/PD-L1 therapy [10]. In our research, we produced mouse tumor cell lines unresponsive to IFN- arousal and examined their reaction to treatment with PD-L1-preventing antibody. Tumors induced by these cells were private to acquired and anti-PD-L1 PD-L1 appearance in vivo. This finding shows that the exceptional abrogation of IFN- signaling in tumor cells isn't sufficient for a getaway from anti-PD-L1 treatment and really should not be considered a reason behind the exclusion of sufferers out HQL-79 of this therapy. 2. Outcomes 2.1. Characterization of TC-1 or TC-1/A9 Cell Lines with IFNGR1 or PD-L1 Deactivation To be able to assess whether tumors induced by IFN- nonresponsive tumor cells could be delicate to PD-1/PD-L1 blockade and concurrently enhance the effectiveness of immunotherapy of tumors induced by such cells, we prepared TC-1 and TC-1/A9 clones having a deactivated IFN- receptor. In these cells, we identified the PD-L1 and MHC-I surface expression by circulation cytometry (Number 1A). Although TC-1 cells and TC-1 clone having a deactivated IFN- receptor 1 (IFNGR1; TC-1/dIfngr1) markedly expressed PD-L1 and MHC-I molecules, on TC-1/A9 cells and the respective clone with deactivated IFNGR1 (TC-1/A9/dIfngr1), PD-L1 and MHC-I manifestation were downregulated. After incubation with IFN-, PD-L1 and MHC-I manifestation were improved in TC-1 and TC-1/A9 cells, but TC-1/dIfngr1 and TC-1/A9/dIfngr1 clones did not respond to activation, which suggests successful IFNGR1 deactivation. Oncogenicity of the revised clones was similar to that of the parental cells, and TC-1/A9-induced tumors grew significantly faster than TC-1-induced tumors (Number 1B). Open in a separate window Number 1 Characterization of the derived cell lines. Surface programmed cell death protein 1 (PD-1) ligand 1 (PD-L1) and major histocompatibility complex class I (MHC-I) manifestation on unstimulated and stimulated (200 IU/mL interferon (IFN)- for 1 day) cells were analyzed by circulation cytometry in TC-1, TC-1 clone having a deactivated IFN- receptor 1 (IFNGR1; TC-1/dIfngr1), TC-1/A9, and TC-1/A9/dIfngr1 cell lines (A) and TC-1/dPD-L1 and TC-1/A9/dPD-L1 cell lines (C). Cells were incubated with specific antibodies or isotype RGS20 control antibodies. (B) Oncogenicity of TC-1, TC-1/dIfngr1, TC-1/A9, and TC-1/A9/dIfngr1 cell lines was compared after subcutaneous (s.c.) administration of 3 104 cells to C57BL/6 mice (= 5). (D) For the evaluation of oncogenicity of cell lines with deactivated PD-L1, numerous cell doses were s.c. injected. The percentage of mice having a tumor to the total number of mice in the group is definitely demonstrated. Bars SEM; **** 0.0001. To evaluate the effect of PD-L1 molecules indicated by TC-1 and TC-1/A9 cells within the safety against immune system attack, we generated cellular clones with deactivated PD-L1CTC-1/dPD-L1 and TC-1/A9/dPD-L1, HQL-79 respectively. As assessed by circulation cytometry (Number 1C), both clones remained PD-L1 bad after IFN- HQL-79 activation. The MHC-I manifestation was not markedly modified on unstimulated TC-1/dPD-L1 cells, but it was slightly improved on unstimulated TC-1/A9/dPD-L1 cells in comparison with the TC-1/A9 cells. This manifestation was further enhanced after IFN- treatment on both cell lines. Oncogenicity of the.


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Edward Enninful has been confirmed as the new editor-in-chief of British Vogue.
Currently Creative and Fashion Director of American magazine W, Enninful will be the first male to edit the title in its entire 100-year history.
"I am pleased to announce the appointment of Edward Enninful, OBE, as Editor of British Vogue effective August 1, 2017," said Jonathan Newhouse chairman and chief executive of Condé Nast International in a statement.
"Edward is one of the most talented and accomplished fashion editors in the world."
Newhouse also called Enninful "an influential figure in the communities of fashion, Hollywood and music which shape the cultural zeitgeist", adding that "by virtue of his talent and experience, Edward is supremely prepared to assume the responsibility of British Vogue."
Enniful being made an OBE by the Princess Royal.
The Ghanaian-born and London-raised creative will begin his role in August, succeeding Alexandra Shulman, who resigned in January after 25 years at the helm of the title.
Well versed in the fashion world, Enninful's experience as a fashion editor dates back to 1991 when he was appointed as fashion director of i-D magazine at 18-years-old, making him the youngest-ever fashion director of an international fashion title.
He also picked up an OBE from the Queen last year, and was named fashion creator of the year in 2014 by the British Fashion Council.
When she left he role after 25 years, Ms Shulman said: "During that time I have worked with an unparalleled collection of talent both inside and outside the magazine and have been lucky enough to see both Vogue and the British fashion industry expand and flourish.
"It has been very hard to find a rational reason to leave what is unquestionably a fascinating and rewarding role but last autumn I realised that I very much wanted to experience a different life and look forward to a future separate to Vogue."
"My career at Condé Nast has been everything I could have wished of it and my heartfelt thanks go to Nicholas Coleridge and Jonathan Newhouse for giving me so many opportunities, trusting me to take care of the precious cargo that is Vogue and allowing me the freedom to do the job exactly how I wanted."


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Q: one more empty P element?

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Why h1 have 3 children ?
It should be 2, which are 2 P elements.
Why there's 1 more extra empty P elements ?

A: Because of the nested P TAG.

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The above code will be rendered as:

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*1st p tag will automatically get a closing partner

*2nd p tag and 3rd p closing tag will work properly as partner

*4th p closing tag will generate an opening p tag to partner the leftover closing p tag. therefore creating the 3rd P TAG
I knew this by experience. I haven't dive deep why this is being rendered like this.
hope it's understandable and helped you.

redpajama_set_name: RedPajamaStackExchange


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5. Applications: Control and guide the rivers and floods.
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Complete visual culture modules that will underpin your studio work.
Be encouraged to enter competitions and complete projects set by leading designers.
Develop an industry ready portfolio and refined business profile.
Learn exhibition skills which allow you to promote your work or curate shows for others.
Develop a professional profile including full use of social media and web site exposure.
Most of your time will be spent in our first-rate studios and workshops, although your practical work will be complemented by a programme in Visual Culture during your first two years. Assessment is by 100% coursework with no exams. Your final Degree Show exhibition forms an essential part of assessment.
Graduates have established varied and exciting careers in fields such as textile design, interior design, decorative product design, automotive design, style forecasting, retail management, design management, buying, trend forecasting and gallery sales.
Applicants are required to have a Foundation Degree or HND in a related discipline. We also require students to possess GCSE English at a minimum of Grade C.
All students are asked to present a portfolio of work at interview, which must demonstrate your creative skills, subject knowledge and enthusiasm for study. It should include research material and project work.
We run Portfolio Workshops throughout the year to help prospective students prepare for interviews - visit our website to sign up.


text:
Leaving the University of Sheffield
Today is my last day at the University of Sheffield before I move to become Vice-Chancellor at the University of Hull, starting tomorrow.
An aerial image of the University of Sheffield campus.
I joined the University of Sheffield in November 2016, taking up the role of Vice-President (Research and Innovation). Over time that role evolved such that in recent years I have overseen the Innovation portfolio, including knowledge exchange and regional engagement, and I have provided board level leadership for the Advanced Manufacturing Group, including the AMRC, the Nuclear AMRC and the AMRC Training Centre. Meanwhile I have continued to develop my own research, albeit in a more limited way than before, and of course I have continued to post to this blog.
My time at the University of Sheffield has been simply and truly wonderful. It has been a privilege to work with immensely talented and deeply passionate people. Sheffield is a wonderful city – so dynamic and so friendly, but so very modest about itself. I have many people to thank – it is impossible to pay tribute to you all – but I would like to highlight Elaine, who cleans my office and who is a true friend (I will miss our morning chats); Debbie and Niccole, my long-suffering PAs without whom I could not have functioned; Sarah, who provides inspirational leadership to the Partnership and Regional Engagement team; Vanessa, who leads the university's exceptional cultural work across the region; Andy, who has transformed the ways in which we commercialise our research; Yasmin, who has brilliantly led the work that we undertake across South Yorkshire; and Wyn, who held the Education portfolio when I was leading research and innovation, and who has been a constant source of support. Behind those wonderful people is a huge wider community of academics and professional service staff, and of course my colleagues in the University executive Board. Thank you to you all.
I do also want to thank my colleagues who have worked with me to transform the AMG. The challenges we faced when we established this new leadership team were complex. Steve, Andy, Nikki, Iain and Beth, and the teams that they lead, have been an inspiration to me. The AMG is a true gem, and I leave it in the very best hands.
I feel proud of what we have achieved. Over the almost six years we changed the ways in which we support our research; we established four new Flagship Research Institutes; we developed a new approach to commercialisation (and I feel so proud of the spinout companies that emerged); we worked with the Universities of Manchester and Leeds to create Northern Gritstone; we created the Advanced Manufacturing Group and reset the strategy of the three component centres; we re-established the role of the University in South Yorkshire and beyond; we have developed the University of Sheffield Innovation District; and so much more. My role has never been anything more than to empower and support those people that do the real work, so the credit lies with them. And of course much of this has been achieved during Covid, which has been extraordinary in so many ways.
Firth Court at the University of Sheffield, my base since 2016.
And so now to the the next step. I will leave this afternoon with great sadness but also real pride. The University of Sheffield has been the best of times in my career to date. Thank you Sheffield, I will be forever grateful. There are great times ahead for the institution.
And so to the University of Hull – I feel so very excited about my new role in an institution that is truly wonderful and special.
Nancy Westrell says:
Happy trails, to you! Best wishes in your new role at U of Hull!
Joan Skidmore says:
Congratulations on starting a new adventure! I hope you have fun. I have seen some amazing things through the newsletter.
Pathma says:
Best wishes! I've been following this blog for several years now. Looking forward to see this continue!
Ramon Mendoza-Borunda says:
Congratulations and good luck!
Ian Cunning says:
Congratulations on your new role at Hull. The Landslide Blog is a great site.
Muhammad Basharat says:
Best wishes and good luck for your new job
Kumar Raut says:
Congratulation for your new role at Hull. Landslide blog is great and resourceful site. I hope you will continue to post this blog.

redpajama_set_name: RedPajamaCommonCrawl


This site is owned and maintained by Peasmarsh Parish Council.
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Peasmarsh Parish Council makes every effort to maintain the accuracy of the information on this website but cannot accept responsibility for and disclaims all responsibility for any loss or damage which may arise from the use of the information provided. Links to external sites are provided as a convenience to users and such sites are not under the control of Peasmarsh Parish Council. The inclusion of any link does not imply endorsement of that site by Peasmarsh Parish Council and the we are not responsible for the contents of any linked site or indeed any link contained in a linked site or for any loss or inconvenience arising from the use of such a site.


The Home Team Wins: Lower a ladle and get me out of here!
I'm in a cooking rut...anyone want to join me? It's quite nice down here in the Rut since no one expects much out of me and my kitchen. I can put peanut butter and jelly, bread, and mac and cheese on the table for dinner and no one complains because they all know I'm in the Rut and that's the best they'll get from me. Lately all I have to do is pretend I'm actually opening the spice cabinet and I get applause for being creative. But then they realize I'm only reaching for vitamins, which is surely the only thing keeping us breathing lately.
What? No takers? No one wants to jump in the Rut with me? Then help me claw my way out. Please? Help?
Please post in the comments your go-to recipes, the ones you fall back on that you know your families will devour. Maybe they're just little menus you put together for easy dinners. Crockpot recipes, too! I love my crockpot but it has been neglected of late, along with my pots, pans and three drawers of utensils.
And what simple dessert ideas do you have? I don't need a chocolate cake hanging around for days (or hours, who are we kidding) but it would be nice to serve something twice a week or so that isn't a cookie. My fingers are getting blisters from opening those packages.
In addition to trying your ideas, I will be visiting sites like All Recipes and A Year of Crockpotting as well.
Thanks guys. My boys thank you, Pete thanks you (and will probably pay you).
Brown the hamburger. Drain grease, then add taco seasoning and water amount on the back of the package. Let simmer 5 minutes. Then dump all of the ingredients into a large pot or a crock pot and simmer. (1 hour in a large pot, all day in a crock pot) Serve with sour cream, cheddar cheese, and tortilla chips.
P.S. I don't know you, but I love your blog!
That is the link -- I have a GREAT dilled grilled Salmon recipe (my neighbor says it works great in the oven too), and an easy-peasy banana pie recipe (use a pre-made graham cracker crust). I have been cooking a lot more lately. Maybe I'll start posting our family favorite recipes since I've been uninspired lately!
these are some of my favorites...do not be fooled if they seem obscure/difficult - they are neither!
Fill a baking pan with and combination of frozen fruit (I like to just use strawberries - berries are definitely best for this if you want fast and easy).
Top it with dry yellow cake mix until it covers fruit.
Top the cake mix with small slices of butter until it covers most all of the mix.
Bake at 350 until topping starts to brown. Let me know if you try any of these!
PS- How's Harry Potter coming? I just re-read book 6 and 7. You have GOT to finish, if only to read book 7. It's incredible and I'm mourning the fact that it is over by watching all 5 movies tonight and tomorrow while the tropical storm hits NYC.
We do fish tacos for an easy meal. My girls even it eat- Sammy said "This is the best chicken I've ever had in my life."
Mix sour cream, lime juice and fresh cilantro as far in advance and you think about it. put in fridge and leave there until dinner time.
Marinade Tilapia in olive oil, lime and/or lemon juice, salt pepper, cumin and chili powder- put in fridge for 8 or 2 or 1 hours 30 or 15 minutes- what ever you have time for.
Grill fish on a grill pan or skillet for about 4 minutes per side then crumble up and serve on warm corn tortillas with the sour cream, raw cabbage, onions, avacadoes, tomatoes, cheese. I usually do a can of refried beans and "taco rice" (the 7 minute kind) as well for the kids.
I'll be watching these comments we keep doing the same old same old as well.
Thanks for all these ideas so far! I'm planning to try a few and post about them later. Keep 'em coming!
Put all three in a crockpot and cook on low all day.
The chicken comes out so tender you can shred it with a fork. Then you just put it in any kind of taco shell (hard, soft, corn, flour) with toppings like cheese, lettuce, picante, etc.
I like to make extra chicken and freeze it for another day.
Well, jw beat me to it! I was going to suggest her taco chicken crockpot wonder. She made it for us one day and the kids loved it, so easy. I love using the crockpot.
I tried these last week and somehow missed the part where it says to make them quarter size. I made mine golf-ball size. I ate one and thought I could never eat dessert again because they were so rich! At any rate, it's not a cookie, it's not a cake, it's bitesized if you read the directions (ahem), and they do freeze well. (Yes, I had leftovers, they are that rich.) And they were fun to make.
i made cake balls last week! used chocolate cake, white frosting with sprinkles and white chocolate coating. you're not kidding about them being rich.
but someone has got to come up with a new name for them. my roommates were not so excited when i asked if they wanted some cake balls (until they tasted them, that is).
They've given you some great ideas. I make the taco soup but I use chicken and also add mushrooms.
How about Cola Chicken- several boneless chicken breasts cut up, brown then in your skillet, add a can of soda (I've used Diet Coke and Diet Dr. Pepper) and one cup of catchup. I usually add salt, pepper and garlic powder too. Then let it simmer for about 10 min or so.
Let's do come up with a new name for the cake balls. They are worth trying again. I'll bet yours were very pretty.


Are you searching for new artists and songs? Can I send you a demo?
No. At the moment we don't need more artists or third party songs.
Can I do a cover-version of Lovetraxx-song "XY"?
Yes, but please contact us before you start.
Can I do a remix of song "XY"?
No. An allready released song don't need more remixes.
Can I license Lovetraxx song "XY" for a video, a film or a commercial?
Can I license Lovetraxx-song "XY" for a compilation?
Can I use Lovetraxx song "XY" on YouTube?
Yes, you can use any of our songs as music on your Youtube-videos without further permission (as long as you have bought the song and don't have changed the original track). This is only for YouTube.
Can your songs be played in a club, on radio or tv?
Yes. All our songs can be used by DJ's in the club or on radio/tv (Labelcode is 18091). Perhaps in some countries you have to log on a collecting society (e. g. Gema in Germany).
Can I write about your songs on my blog or on a social media plattform?
Yes, feel free to put our songs in your news-section or write a review.
Do you have a Dj-Pool or promotion pool?
Yes, but it is currently not active. This may change in the near future.


text:
Q: How do I change the spacing (between lines/paragraphs) in my mobile footer - css? Code below is from responsive.css wordpress How do I change the spacing (between lines/paragraphs) in my mobile footer - css? Code below is from responsive.css wordpress
this is from the responsive.css part of my wordpress
I want the spacing to be closer than what it is currently - you can check it by visiting www.hotdatajobs.digitalya.ro
/* new changes footer */
    @media ( max-width: 640px ) {
        .col-xs-12.p-t-20.padding-l-r-10 span {
            font-size: 18px;
        }
        .site-footer {
            padding-top: 40px;
        }
        .footerRow .col-md-15.col-sm-15.col-xs-12 .title-block {
            margin-bottom: 10px;
        }
        .m-h-f {
            min-height: 295px;
        }
        .m-h-l {
            min-height: 170px;
        }
    }

    @media ( max-width: 440px ) {

        .m-h-f,
        .m-h-l {
            min-height: 100px;
            margin-bottom: 20px;
        }

        .m-h-f {
            min-height: 230px;
        }

        .p-l-f {
            width: 150px!important;
        }

        .site-footer .footerRow .footer-social-item {
            font-size: 16px;
        }
        .site-footer .footerRow a {
            font-size: 14px;
        }
        .col-xs-12.p-t-20.padding-l-r-10 span,
        .site-footer .title-block {
            font-size: 16px;
        }
    }

    @media ( max-width: 374px ) {

        .m-h-f,
        .m-h-l {
            min-height: 100px;
            margin-bottom: 20px;
        }

        .m-h-f {
            min-height: 225px;
        }

        .p-l-f {
            width: 110px!important;
        }

        .footerRow .col-xs-12 {
            padding: 0;
        }
        .site-footer .footerRow .footer-social-item {
            font-size: 14px;
        }
        .site-footer .footerRow a {
            font-size: 12px;
        }
        .col-xs-12.p-t-20.padding-l-r-10 span,
        .site-footer .title-block {
            font-size: 14px;
        }
    }
    /* end general */

A: You can control spacing between lines of texts with the line-height property.
For example, 16px font-size and 4px distant from the bottom and upper lines:
line-height: 24px; /* 4px +16px + 4px */

Or with em units
line-height: 2em; /* 1em = 12px in this case. 24/12 == 2  */

So..
.site-footer .footerRow .footer-social-item {
    font-size: 16px;
    line-height: 24px;
}

Of course, increasing of decreasing the line-height depending on how much spacing you want. Anything below 16px will cut off your text because you are using 16px text so keep that in mind.
Also keep in mind that when the width of that div gets greater than 440px the line-height value will not apply.


text:
Q: Any advantages when running a Rails application on Tomcat+JRuby instead of Mongrel/Passenger? I want to install a Rails application (Redmine) on my Root Server. Since i'm already planning to run a Tomcat for various Java applications, I'm asking myself (and you) if it makes sense to also let the Rails application run on Tomcat6+JRuby, or if i should extend an (already running) Apache with Passenger and run the Rails app "natively".
What Pros and Cons are there between running the Rails app on a "native" Rails server compared to a Java Server+JRuby?

A: I'm not a JRuby expert, but I have used it for a couple things recently, and in my opinion the big win with JRuby is the ability to use Java code (including existing Java libraries) in your Ruby code, and the ability for Java to call and/or embed Ruby. (Most of JRuby's documented success stories involve the ability to access Java from Ruby.) Also, it is possible to run JRuby on systems that may be difficult or impossible to get MRI to run on.
There are some differences between MRI and other C-based rubies and JRuby you should be aware of; they are documented on JRuby's wiki.
In my opinion (and others may disagree), if you're already running MRI-ruby based services, etc. and you don't need to access any Java functionality, I would run my Rails app on MRI.


text:
Macaulay, Thomas Babington, Baron Macaulay of Rothley
born Oct. 25, 1800, Rothley Temple, Leicestershire, Eng.
died Dec. 28, 1859, Campden Hill, London
English politician, historian, and poet.
While a fellow at Cambridge University, Macaulay published the first of his essays, on John Milton (1825), and gained immediate fame. After entering Parliament in 1830, he became known as a leading orator. From 1834 he served on the Supreme Council in India, supporting the equality of Europeans and Indians before the law and inaugurating a national educational system. He reentered Parliament on returning to England in 1838. He published Lays of Ancient Rome (1842) and Critical and Historical Essays (1843) before retiring to private life and beginning his brilliant History of England, 5 vol. (1849–61); covering the period 1688–1702, it established a Whig interpretation of English history that influenced generations.
Thomas Babington Macaulay, detail of an oil painting by J. Partridge, 1840; in the National ...
Courtesy of The National Portrait Gallery, London
MacNeice, Louis
Macchiaioli
Macaulay, Thomas Babington, barón Macaulay de Rothley — (25 oct. 1800, Rothley Temple, Leicestershire, Inglaterra–28 dic. 1859, Campden Hill, Londres). Político, historiador y poeta inglés. Mientras ejercía su cátedra en la Universidad de Cambridge, Macaulay publicó el primero de sus ensayos, sobre… … Enciclopedia Universal
Macaulay, Thomas Babington, Baron Macaulay — (1800 1859) Born at Rothley Temple, Leicestershire, son of the philanthropist Zachary Macaulay, he was educated at Trinity College, Cambridge, where he won the English prize for a poem in 1819 ( Pompeii ) and in 1821 ( Evening ). Called to the … British and Irish poets
Thomas Babington Macaulay, 1st Baron Macaulay — Thomas Babington Macaulay, 1st Baron Macaulay, PC (25 October 1800 ndash; 28 December 1859) was a nineteenth century British poet, historian and Whig politician and one of the two Members of Parliament for Edinburgh. He wrote extensively as an… … Wikipedia
Thomas Babington Macaulay, 1. Baron Macaulay of Rothley — Thomas Babington Macaulay, 1. Baron Macaulay of Rothley, (* 25. Oktober 1800 in Rothley Temple, Leicestershire; † 28. Dezember 1859 in Kensington) war ein britischer Historiker, Dichter und Politiker. Inhaltsverzeichnis 1 Leben 2 Literatur 3 … Deutsch Wikipedia
Thomas Babington Macaulay — Thomas Babington Macaulay, 1. Baron Macaulay of Rothley, (* 25. Oktober 1800 in Rothley Temple, Leicestershire; † 28. Dezember 1859 in Kensington) war ein englischer Historiker, Dichter und Politiker. Inhaltsverzeichnis 1 Leben 2 Literatur 3 … Deutsch Wikipedia
Macaulay, Thomas Babington Macaulay, Baron — ▪ English politician and author Introduction in full Thomas Babington Macaulay, Baron Macaulay of Rothley born October 25, 1800, Rothley Temple, Leicestershire, England died December 28, 1859, Campden Hill, London English Whig (Whig and Tory)… … Universalium
Macaulay — (spr. mǟckaolĕ), Thomas Babington, Lord M. of Rothley, berühmter engl. Geschichtschreiber, geb. 25. Okt. 1800 zu Rothley Temple in der Grafschaft Leicester als Sohn eines aus Schottland stammenden Kaufmanns, gest. 28. Dez. 1859, studierte in… … Meyers Großes Konversations-Lexikon
Thomas — Thomas, Albert Thomas, André Antoine Thomas, Ch. L. Ambroise Thomas, Dylan Thomas, Sidney Gilchrist Thomas, Theodore * * * (as used in expressions) Adès, Thomas … Enciclopedia Universal
Macaulay — [mə kɔːlɪ], 1) Dame (seit 1958) Emilie Rose, englische Schriftstellerin, * Rugby 1. 8. 1881, ✝ London 30. 10. 1958; griff in ihren kulturkritischen, meist satirischen Romanen Fortschrittsglauben und Kulturoptimismus der englischen… … Universal-Lexikon
baron — /bar euhn/, n. 1. a member of the lowest grade of nobility. 2. (in Britain) a. a feudal vassal holding his lands under a direct grant from the king. b. a direct descendant of such a vassal or his equal in the nobility. c. a member of the House of … Universalium


text:
Building 2, 5 Sherborne Road, Parktown, 2041, South Africa
+27 [0]11 489 3600
info@carst.co.za
Hobart Companies
Adhesives & Coatings
Fillers & Extenders
Functionals Monomers & Oligomers
Polymers, Resins, Dispersions, Emulsions
Consumer Specialities
Anchor Chemicals
Fillers & Additives
Plastics & Composites
Auxiliaries & Services
Hobart Group of companies has purchased Davro
Article featured in SA Plastics, Composites & Rubber magazine
Anchor Chemicals, a subsidiary of Zenith Holdings, part of the Hobart Group of companies, has purchased Davro Marketing, the Durban based compounder of thermoplastic rubber and TPEs.
The acquisition was completed over a year ago, since when the business has been renamed Davro Compounding and the plant has been relocated from Jacobs to much larger premises in Mahogany Ridge, Westmead.
A state-of-the-art Farrel Pomini compounding unit has recently been installed and commissioned. One of the most advanced compounding systems in the southern hemisphere, the new line has the capability and flexibility to process a wide range of plastic and rubber materials using highly energy-efficient technology.
This is a major undertaking for the Hobart group of companies, which in South Africa also incorporates Carst & Walker, their speciality raw material distribution business, and Anchor Chemicals, a speciality adhesive and rubber chemicals manufacturer.
There has been little development in the local market for speciality compounded polymers over the past few years due to the exit from the market of Synthomer Revertex and more recently of Plastamid and Lomotek. The newly named Davro Compounding is now ready to meet the demand.
Dave Watson of Davro Marketing has been retained as a consultant in the new venture.
Image: The management team at Davro Compounding – Jaco Smith, Lucas Ndimbovu, Dave Watson and Gareth Akerman – are very pleased with the business's new Farrel Pomini system, one of the most versatile and energy-efficient compounding lines around
By admin April 26, 2017 0 Comments
Carst & Walker (C&W), was established in South Africa in 1934 and has over the years expanded to become a substantial importer and distributor of chemical raw materials which find application in the adhesive, coatings, food, paper, plastics and rubber industries.
Building 2, 5 Sherborne Road
All companies that are part of the Hobart Enterprises Group display the logo below. Click on the logo to view companies in the group.
Carst & Walker © 2019. Proudly powered by Plusto Websites.


Wheat Bran Pellets produced by Millers Group exhibit high protein content, conferring feeding products all necessary nutrients for pets to grow healthily.
Upon request, we can incorporate different additives and minerals which some animal species require when raised with commercial purposes. In this way, Millers Group has custom solutions for the efficient and profitable agribusiness production.
For those reasons our Wheat Bran Pellets are welcome in the animal community, serving as the alimentary base for all kind of species such as poultry, pets and companion animals, horses, sheeps, cows and pigs.


text:
<?php if (!defined('BASEPATH')) exit('No direct script access allowed');

class Profile extends Public_Controller
{
    function __construct()
    {
        parent::__construct();

    }
    public function index()
    {
        $this->user = CheckmydriveHelper::getUser();
        $view = strtolower(get_class($this));
        $this->template->build($view);
    }

    public function closeacc(){
        $user = Checkmydrive::getUser();
        $data = array(
            'ok' => true
        );
        if(!$user->id || !Checkmydrive::hasSubscriber()){
            $data['ok'] = false;
            $data['msg'] = 'Are you not permisstion';
        }else{
            $this->tank_auth->logout();
            $db = Checkmydrive::getDbo(true);
            $db->set('banned',1)->set('ban_reason','The Account of Admin have been closed.')->where('created_by', $user->id)->update('users');
            $db->set('banned',1)->set('ban_reason','The Account have been closed')->where('id', $user->id)->update('users');
            $data['msg'] = 'The Account have been closed';
        }
        die(json_encode($data));
    }

    public function saveUser(){
        $CI = get_instance();
        $data = $this->input->get_post('user');
        if(!isset($data['id'])) $data['id'] = Checkmydrive::getUser()->id;
        $db = Checkmydrive::getDbo(true);
        if(isset($data['password'])){
            if($data['password'] == $data['password2']){
                $hasher = new PasswordHash(
                    $CI->config->item('phpass_hash_strength', 'tank_auth'),
                    $CI->config->item('phpass_hash_portable', 'tank_auth')
                );
                $data['password'] = $hasher->HashPassword($data['password']);
                unset($data['password2']);

            }else{
                exit(json_encode(array('rs'=>true, 'msg'=>Checkmydrive::_('The passwords you entered do not match!'))));
            }
        }else{
            unset($data['password']);
            unset($data['password2']);
        }
        $db->where('id', $data['id']);
        $sucess = $db->update('users', $data);
        //Set new session
        //$session = Checkmydrive::getSession();
        //$session->set('user', new JUser($user->id));
        exit(json_encode(array('rs'=>true, 'msg'=>Checkmydrive::_('CLIENTROL_MSG_SUCCESSFULLY'))));
    }

}

redpajama_set_name: RedPajamaGithub


Team Beachbody® is where your healthy lifestyle begins. I help you achieve results with a combination of proven home fitness programs, easy-to-follow meal plans, nutrition advice, and a support system like no other.
I am a Beachbody Coach. Beachbody, the company, actually started about 10 years ago strictly selling home DVDs from infomercials. About 5 years ago, the CEO Carl Diakler and Shakeology creator Darin Olien came together to offer workouts AND nutrition to their clients and the company branched into the Network Marketing world with Coaches that could not only offer the workouts with nutrition to their clients, but now could offer the missing piece, which was accountability.
The workouts that Beachbody offers range from very moderate for beginners or older clients like Tai Chi, 10 Minute Trainer, or the 21 Day Fix to more intense for more advance exercisers like T25, the 21 Day Fix Extreme, or P90X3 or very intense for athletic trainees looking for off season training or cross training like Insanity, Insanity the Asylum, the P90X series, or Body Beast.
Shakeology is the healthiest meal of the day! It is NOT a protein shake or your average meal replacement. It was not designed as a weight loss supplement like some of the things you see on your grocery store shelves, but rather it was designed to give your body whole food nutrition and feed it what it needs on the cellular level and more as a side effect so you end up losing weight. Studies have also shown it to lower blood pressure, cholesterol, level out sugar and insulin, reduce sugar cravings, relieve constant headaches and migraines, and SO much more!! It's like drinking your multivitamin and hitting the salad bar 7x's every day.
So…in 2017, Raise The Bar. Together – we will work hard. We will learn. We will get better. We will grow. Because that's how it's done. That's who we are. We are a Team.


"... This paper presents an expressive language for representing knowledge about vague concepts. ..."
This paper presents an expressive language for representing knowledge about vague concepts.
"... and fuzzy-rough methods for mammographic data analysis ..."
"... machining processes surface ..."


You'll be amazed at where our AMX alarm management software ends up being installed. What's more because of the way we go to market we don't always know who the end user is either!
However, there are some important and significant premises that utilise our software to help manage the thousands of fire sensors that populate modern buildings. Every commercial building has to have a fire detection and alarm system, in the main to warn the occupants of the need to evacuate the premises in the event of a fire. However, as buildings get bigger, more complex and the level of occupation increases the requirements for a comprehensive fire detection and alarm system become more onerous. This is great for the safety of the building and its occupants but brings about a number of challenges for the premises management. Firstly, it's important to know where all the fire sensors and manual call points are located, are they working and most importantly of all when were they last tested.
Take a building like The Shard, one of London's tallest. The building has a range of tenants with different requirements such as a hotel, offices, bars, retail and members of the public to its upper floor viewing gallery. Ensuring the safety of everyone in the event of a fire is paramount. And whilst this was a new building with a new fire detection and alarm system, standard off the shelf fire detection and alarm control panels only provide a limited amount of information with respect to the device in alarm and its location and no information to operational staff as to what to do in the event of a fire in a particular location. Drax Technology's proven AMX software can add a significant amount of additional detail to help in the event of an unforeseen emergency event.
Many of the organisations that purchase our AMX alarm management software buy it to integrate numerous fire detection alarm systems that have been installed on a piecemeal basis over many years. As a consequence these systems have been supplied by different fire specialists using equipment from different manufacturers. Fortunately for Drax Technology this is not an issue as our AMX alarm management software can be equipped with different network managers capable of communicating via a serial port with virtually all the major fire alarm control panel manufacturers control panels.
The NHS is an end user that uses our AMX alarm management software extensively to protect patients and staff and help the trust comply with the requirements of their fire risk assessment by recording every event that occurs. Universities have similar requirements to hospitals with a large sleeping risk often on a sprawling campus comprising many buildings with disparate fire detection and alarm systems.
Railway stations, airports and shopping centres are another group of users that utilise the Drax software. There are many similarities with these three. Large numbers of people often unfamiliar with the buildings pass through every day. These establishments usually include a large number of retail units again with fire detection and alarm systems of different manufacture. Keeping a close eye on maintenance and the constant changes that regularly occur to the building's infra-structure is invaluable and our software adds a level of detail available to operational staff, that cannot be provided by a standard fire detection and alarm system.
As you can see, the requirements of these larger establishments are not exclusive due to their size. Many smaller buildings can benefit from our alarm management system by delivering a cost effective way of providing an electronic log book, asset register, and audit trail as well as detailed additional information to key staff in the event of a serious fire incident. For more information or a chat about your particular requirements just give us a call on 0345 459 2300 or email, sales@draxtechnology.com.


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and launch following command to retrieve these dependencies/ modeles from repositories.
Just download the proposed zip file and unzip it into the .gnome2/gedit/plugins folder.
Restart gedit if it's already running.
you will get the plugin ready to use.
figure 2.3 – Detected project into browsed directory.
figure 2.4 – Play! project importer into Eclipse, ready at work !
And the you will be free as bird to parse excellent documentation provided by the play distributed archive.


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Recap: the 2020 Vice Presidential debate
Anna Gould, Reporter
On Wednesday night, current Vice President Mike Pence and California Senator Kamala Harris battled toe-to-toe during the only Vice Presidential debate of this important election season. With moderator Susan Page from ABC news in charge, the two candidates hashed it out discussing topics, like the pandemic, health care, the economy, climate change and racial injustice, that are central to our democracy.
Right off the bat, Senator Harris did not hesitate to condemn Mike Pence and the Trump Administration with their handling of the coronavirus. Calling Trump's reaction to COVID-19 the "greatest failure of any presidential administration in the history of our country" when he knowingly did nothing to stop the spread in early February, Harris capitalized on being truthful to the American people. She made it explicit that transparency while in office is a crucial part to running the country, especially during a global pandemic. With this, Senator Harris stated, "You respect the American people when you tell them the truth." She actively rolled out Joe Biden's plan for handling our current situation by mandating a national contact tracing strategy, a secure testing program and a safe and reliable vaccine that is available to all.
To retaliate, Vice President Pence insisted that fighting against this deadly pandemic means putting "Health in America first." As a solution, he laid out the Trump Administration's plan to distribute a vaccine by the end of the year, which leading health experts like Dr. Anthony Faucci find very unlikely. Pence also made it clear that China was to blame for the spread of COVID-19, which has killed more than 200,000 in the United States. In contrast to his own rhetoric, he devised plans to make amends with China all the while making them pay for the damage that they did to our country.
A heated topic that goes hand-in-hand with the current situation is the economy, which both candidates debated heavily throughout the 90-minute program. Pence was adamant on telling the American people that the economy has been prosperous under Trump and is expected to stay on track to have the biggest economic year yet in 2021. However, this is not entirely true. The current unemployment rate sits at 7.9 percent, a drastic drop from 14.7 percent in April, but it has no indication of tapering off soon. Pence also capitalized that out of the 22 million jobs lost at the beginning of the pandemic, 11.6 million were added back, which still puts the economy at a 10.4 million job deficit.
Senator Harris took a different perspective when explaining our current economic situation. She contrasted President Trump's handling of the economy to what Biden will do if the election were to sway in his favor. Taking a patriotic approach, the Senator said, "Joe Biden believes you measure the health and strength of America's economy based on the health and the strength of the American worker and the American family." With this move, she quickly criticized the tax bill Trump passed that only benefited the wealthy. At the same time, Harris rolled out Biden's economic plan for the future: repealing that same Trump tax bill, raising taxes on those who make more than $400,000 and making community college free.
Just like when President Trump refused the dismissal of white supremacy, Vice President Pence never clearly stated that climate change is a real and prominent problem to our society. When questioned on the topic, Pence answered, "The climate is changing," but quickly switched the subject and attacked Harris on her environmental policies and future plans to rejoin the Paris Climate Accord. Not only this, Pence repeatedly made the claim that Biden was in favor of abolishing fracking. While this may not be entirely true, the Vice President was relentless on bringing back the topic to the discussion.
In contrast, Senator Harris stated her beliefs in climate change and assured the American people that Biden listens to the scientists. She recognized the existential threat that climate change brings and focused on investing in renewable energy. With this, the Biden and Harris campaign hopes to create millions of jobs, achieve net zero emissions by 2050 and become carbon neutral by 2035.
Holding her own, Senator Harris wasted no time discussing social issues like abortion and racial injustice while on the debate stage. When talking about the former, Harris explained her pro-choice approach to women's reproductive rights, which are at stake if the landmark Supreme Court case, Roe v. Wade, is repealed. "I will always fight," Harris began, "for a woman's right to make a decision about her own body." This starkly contrasts Pence's views on the subject. When prompted with a question pertaining to how he would handle the abortion situation in Indiana, where he formerly governed, the Vice President did not exactly give a clear answer. After meandering around the question, Pence finally circled back and gave an answer: "I'm pro-life. I don't apologize for it." Upon this statement, he made the claim that the Biden and Harris campaign are strong believers in using tax payer's money to fund abortions, which is untrue.
The final topic covered during the debate is prevalent to our current societal circumstances, racial injustice. In the midst of a social revolution, the two candidates took wildly different stances. Harris, a former federal prosecutor for the state of California, weighed in on the Breonna Taylor case that has shocked our nation. She remarked that Taylor did not receive justice and that her life was taken, "unjustifiably and tragically and violently." Going even further, the Senator stated, "Bad cops are bad for good cops," which progressed to Biden's plan for police reform: banning chokeholds and carotid holds, a national registry for those police officers who break the law and decriminalizing marijuana among other things.
When asked the same question regarding the Breonna Taylor case, Pence responded very distinctly. He gave sympathy to the families of Breonna Taylor and even mentioned George Floyd, but overall, Pence trusts the justice system. After that, he quickly switched the topic to the rioting and looting that has occurred across the country. While the Vice President did not explicitly state his administration plan for police reform, he did attack Harris on her history as a federal prosecutor.
While this debate may seem more professional than the last, one thing remains the same: it is imperative that you as an American citizen exercise your right to vote. We are not just electing an official into office; we are voting to maintain democracy and the basic human rights that so many of our ancestors fought hard to achieve. The time is now to make a difference.
Anna is a freshman at Lake Land College and is majoring in Communication Studies. She plans to transfer after this...
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I had insomnia again last night and put on the audiobook of Benedict Anderson's Imagined Communities. The best history is always disorienting, and this is premium disorientation, on the order of Inventing the Individual.
According to Anderson, nations and nationalism are a modern phenomenon which uses the past to construct an imaginary present outfitted with an equally imaginary history that provides it a sense of continuity.
Continuity, coherence, clarity are basic human needs, it seems. What varies is how we get these basic needs met — but the way we get them met can erase the variations in how we have gotten them. The continuity, coherence and clarity we have now consist in our sharing that coninuity, coherence and clarity with our ancestors. Human nature seems invariable precisely where it is most variable, but for the sake of what actually is invariable.
These periodic historical disorientations, along with my regular philosophical disorientations have given me a quite different sense of continuity — one of human beings looking for continuity and building it out of whatever materials are closest at hand.
How many "red pill" folks remember that the reality to which Neo awoke was just another dream within nested dreams?
To refuse to know this truth about truth gives a knowing person even more clarity and resolve — even greatness.
To exalt these epiphany-effects is to exalt the power of delusion.
We dream red pills, we dream waking up, we dream enlightenment, we dream reality and call it truth.
We dream wokeness or awakenedness to amass power over those who dream weaker, wider, more liberal dreams.
Our epistemic misnorms are our deepest misnorms.
Even generations get lonely in their time.


text:
Tag Archives: Roger Bernadina
The Daily Feed
By Rachel Levitin 7:45 am16 Sep 2013
Ramos is A Hit Machine, Nats Beat Phillies 11-2
By the ninth inning of Sunday afternoon's 11-2 victory over the Philadelphia Phillies, the Washington Nationals fielded eight players who spend time at Triple-A Syracuse this season. It was a day where most everything went right for Washington, allowing Manager Davey Johnson to give some of the call-up kids a little playing time.
Right-handed starting pitcher Jordan Zimmermann pitched seven strong innings and gave up seven hits and two runs while walking two, striking out seven and hitting a batter on 102 pitches (65 strikes).
For as solid as Zimmermann once he got into a groove, the player of the game was catcher Wilson Ramos who made his 23rd consecutive start behind the dish. Ramos went four-for-four with three singles and a homerun. Continue reading →
Tags: Bryce Harper, Cody Asche, Davey Johnson, Denard Span, Domonic Brown, Jordan Zimmermann, Michael Cuddyer, nats, Philadelphia Phillies, Roger Bernadina, Ryan Mattheus, Washington Nationals, Wilson Ramos, Xavier Cedeno
Sports Fix
By Rachel Levitin 12:54 am05 Jun 2013
Nats Beat Mets 3-2 in Their First Walk-off of the Season
Photo Credit: Patrick Pho
The Washington Nationals were three outs away from a one-run loss against the fourth place New York Mets on Tuesday night but Steve Lombardozzi saved the game by hitting a walk-off sacrifice fly into the glove of Mike Baxter in left field. His sacrifice fly sent first baseman Adam LaRoche around to score. Washington beat New York 3-2 in their first walk-off victory of the season.
The Nats may have won the game but it was night in which the their offense continued to struggle. Manager Davey Johnson's lineup managed four hits before their three-hit ninth inning rally. They were lucky enough to score early on a solo home run hit by shortstop Ian Desmond off right-handed pitcher Jeremy Hefner in the second inning — Desmond's eighth home run of the season — but that's the only run they'd tally up until the ninth inning.
Tags: Adam LaRoche, Bobby Parnell, Denard Span, Ian Desmond, Jayson Werth, Jeremy Hefner, Jordan Zimmermann, Mike Baxter, National League East, nats, New York Mets, Omar Quintanilla, Roger Bernadina, Ryan Zimmerman, Steve Lombardozzi, Washington Nationals
Sports Fix, The Daily Feed, The Features
By Rachel Levitin 9:52 am12 May 2013
Strasburg Struggles, Nats Lose 8-2
courtesy of oddlittlebird.
What started out as a four inning pitching duel between former Nationals pitcher and current Chicago Cub Edwin Jackson and Washington's Stephen Strasburg quickly turned in favor of Chicago due to a messy fifth inning performance from the young phenom. The Nats went on to lose the contest 8-2 on Saturday afternoon. The Cubs hit four unearned runs off of Strasburg in the fourth inning and four more earned runs off left-handed reliever Zach Duke in the fifth to win it.
Strasburg has struggled for the entirety of the 2013 season minus Opening Day. When he lets his emotions get the best of him – like he did Saturday – it's easier to remember just how young he actually is. When Strasburg's got his three pitches working for him, he's a force to be reckoned with, but he's still in the growing phase where he's learning to deal with the adversity within the game itself. Manager Davey Johnson acknowledged that fact that the game.
Tags: Anthony Rizzo, Bryce Harper, Chicago Cubs, Davey Johnson, Edwin Jackson, Henry Rodriguez, Ian Desmond, Jayson Werth, nats, Roger Bernadina, Ryan Mattheus, Ryan Zimmerman, Shawn Camp, Stephen Strasburg, Steve Lombardozzi, Tyler Moore, Washington Nationals, Zach Duke
By Rachel Levitin 12:18 pm11 May 2013
Nats Beat Cubs 7-3 on Friday Night
Despite giving up five doubles in six and two-thirds innings pitched, the Washington Nationals' left-handed starter Ross Detwiler secured his second win of the season with a 7-3 victory over the Chicago Cubs on Friday night.
Detwiler threw 90 pitches, 57 for strikes, and gave up eight hits, two runs, and struck out two batters.
Tags: Adam LaRoche, Anthony Rizzo, Bryce Harper, Chicago Cubs, Craig Stammen, Danny Espinosa, David DeJesus, Hector Rondon, Ian Desmond, Jayson Werth, Jeff Samardzija, Kurt Suzuki, nats, Roger Bernadina, Ross Detwiler, Ryan Sweeney, Ryan Zimmerman, Starlin Castro, Tyler Moore, Washington Nationals
By Rachel Levitin 7:29 am22 Jun 2012
Espinosa Comes Up Big, Nats Beat Rays 5-2
Future All-Stars
Left-handed starter Gio Gonzalez had a shaky start to Thursday night's interleague game between his Washington Nationals and the Tampa Bay Rays. Gonzalez faced seven batters in the second, allowing the Rays to take an early 1-0 lead, but the Nats came back from behind for a 5-2 victory.
Gonzalez had a lot of trouble, according to Manager Davey Johnson, due to "missing the plate" or at least that's what home plate umpire Cory Blaser thought of his performance. He threw 98 pitches, 58 for strikes, over six innings and gave up seven hits, two runs, and two walks while striking out four and throwing one wild pitch. The minor setback was to no avail for Tampa Bay, though, because the Nats regained a temporary lead in the third inning before taking it all back in the sixth.
Second baseman and switch hitter Danny Espinosa went 2-for-4 and had a hand the two plays that put the Nats ahead to beat the Rays. Rookie left-handed starter Matt Moore gave the Nats some trouble but they still managed three hits and two runs off of him over five innings pitched. Moore's struggles in the third came directly after Gio's shaky second inning. That's when Espinosa and outfielder Bryce Harper scored to take the Nats' first lead of the night. Continue reading →
Tags: Adam LaRoche, Bryce Harper, Danny Espinosa, Gio Gonzalez, Matt Moore, Michael Morse, Roger Bernadina, Ryan Zimmerman, Tampa Bay Rays, Washington Nationals
By Rachel Levitin 11:14 am20 May 2012
Nats Offense Attempts A Comeback, Orioles Win 6-5
Nationals Baseball
Nationals starting pitcher Ross Detwiler went into Saturday night's game with a 2.63 ERA and came out of it with a 3.65. Long story short – Detwiler didn't have a good night against the first place Baltimore Orioles.
As the newest member of Steve McCatty's rotation, having landed the fifth spot just before the start of the season, Detwiler's had a good couple months with Washington. The Orioles found a way around that with their bats, though, and that's all it took to secure an early lead and eventual 6-5 victory over Washington. Continue reading →
Tags: baltimore orioles, Craig Stammen, Henry Rodriguez, Jason Hammel, Roger Bernadina, Ross Detwiler, Ryan Perry, Ryan Zimmerman, Steve Lombardozzi, Tyler Moore, Washington Nationals
Sports Fix, The Features
By Samuel Chamberlain 1:17 am28 Jul 2011
Nats Come Up Just Short Against Marlins
'Nats Park'
courtesy of 'oddlittlebird.'
At least on Wednesday night, the Washington Nationals had the decency to make it interesting. Before losing 7-5 to the Florida Marlins and dropping further into the basement of the National League East, Washington managed to piece together four hits and a walk to score four runs in the bottom of the ninth. The last of those hits — a two-run single by Michael Morse — scored two runs and brought Laynce Nix, who had already hit a solo home run in the bottom of the fourth to make the score 3-1 Florida at the time. Nix came within a foot of tying the game, lifting a Leo Nunez change-up very high in the air and very far into left field. But the ball had been hit a little too close to the end of Nix's bat, the ball settled into Mike Stanton's glove instead of in the Nationals bullpen, and Washington had officially lost eight of their last eleven games dating back to the All-Star Break.
Tags: Alex Cora, Davey Johnson, Florida Marlins, Greg Dobbs, Hanley Ramirez, Javier Vazquez, Jerry Hairston Jr, Jesus Flores, Livan Hernandez, Michael Morse, Mike Cameron, Mike Stanton, Roger Bernadina, Ryan Zimmerman Laynce Nix, Washington Nationals
By Samuel Chamberlain 6:32 pm10 Jul 2011
Nats Break Even, Beat Rockies 2-0
'First Pitch: Rockies v. Nationals — Nationals Park (DC) July 10, 2011'
courtesy of 'Ron Cogswell'
In the long-term plans of the Washington Nationals, Jordan Zimmermann will be a No. 2 guy, a complementary left hook to the right-hand lead represented by a healthy Stephen Strasburg. But with Strasburg on the shelf until at least September, Zimmermann became the de facto No. 1 starter entering the 2011 season despite the fact that he would be pitching under a 160-inning limit.
After a very strong 6.1-inning performance in Sunday afternoon's 2-0 win over the Colorado Rockies, which sent the Nationals into the All-Star Break with a record of 46-46 and halted a particularly morale-sapping three-game losing streak, Zimmermann has pitched 115 of his allotted 160 innings. He extended his streak of pitching six innings or more in his starts to 13 and dropped his ERA from 2.82 to 2.66. He was, in short, exactly the man the Nats needed. His slider and curveball were particularly effective on this day, exploding down and away from Colorado's right-handed hitters and, more often than not, finding the outside corner of home plate umpire Brian Knight's strike zone.
Zimmermann's (and Washington's) win didn't come easily, as the Nationals offense continued to struggle. This time, it was Jhoulys Chacin who caused the trouble as he retired the first 11 Nationals he faced before giving up a two-out single to Ryan Zimmerman in the bottom of the fourth inning. That was Washington's last hit before Ian Desmond led off the bottom of the sixth with a laser that deflected off the glove of third baseman Ian Stewart and reached shortstop Troy Tulowitzki far to late for Colorado's All-Star to do anything about it. Zimmermann, proving himself doubly indispensible, laid down a beautiful sacrifice bunt and Roger Bernadina did the rest, driving in the only run the Nats would need with a shattered-bat single to right field. Rick Ankiel, who had entered the game in the eight inning as a defensive replacement, provided the icing in the bottom of that inning with a solo home run into the first row of the right field seats off left-hander Matt Reynolds. It was Ankiel's first home run off a left-handed pitcher since 2008.
Other members of the Nats were not so lucky. Jayson Werth, for one, went 0-for-3 at the plate to drop his average to .215 entering the All-Star Break. The big-money right fielder was greeted with applause by most of the 21,186 at Nationals Park when he was announced for his first at-bat in the bottom of the second inning. The fans held their collective tongues when Werth flied out to center field and left field in his first two at-bats (both times on first-pitch swings), but could restrain themselves no longer when he lifted a meager foul pop-up in the bottom of the seventh inning with Michael Morse standing on second base after a one-out double. At that point, the boos hailed down on Werth all the way back to the dugout.
As the season winds to its conclusion, and as the Nationals (likely) continue to drift around the fringes of the National League wild card race, Werth's ongoing offensive struggles will continue to be the story, at least until he snaps out of it. But unlike on Saturday night, when Werth grounded into a game-ending double play with the tying run at third base, his struggles were only a footnote to Zimmermann's great performance. It's doubtful Werth will take any consolation from this as he prepares for his three days off, but at this point, he'll take any consolation he can get.
Tags: Colorado Rockies, Ian Desmond, Jayson Werth, Jordan Zimmermann, MLB, Rick Ankiel, Roger Bernadina, Ryan Zimmerman, Washington Nationals
By Samuel Chamberlain 12:06 am09 Jul 2011
Rockies Hurt Lannan, Stifle Nats 3-2
'not too happy'
courtesy of 'philliefan99'
If Thursday night's 10-9 loss to the Chicago Cubs was a spectacular defeat for the Washington Nationals, Friday night's 3-2 loss to the Colorado Rockies was more in keeping with past defeats this season, complete with offensive incompetence and a pinch of bad luck.
In this case, actually, the bad luck was a hammer blow in the form of a baseball off the bat of Ty Wigginton in the top of the fourth inning with Washington on top 1-0. John Lannan had started his outing crisply, and had made it through the first three innings without allowing a single baserunner. After Carlos Gonzalez struck out swinging at a two-seam fastball to lead off the fourth, however, things fell apart quickly for Lannan. Jonathan Herrera lined a four-seam fastball back up the middle for Colorado's first hit (and base) of the night. Todd Helton pulled a two-seam fastball over the inner half of the plate into right field to put runners on first and second base. And then Wigginton lined another two-seamer straight at Lannan's skull.
Replays were inconclusive as to whether the ball deflected off Lannan's glove. What was more definitive was the ball striking Lannan in roughly the place where nose and left cheek come together. As the ball continued into center field and Herrera raced home to tie the game at 1-1, Lannan staggered to his knees for a few seconds before picking himself up and walking to the clubhouse under his own power, holding his cap to his face to staunch any bleeding. The official diagnosis was a nose contusion, and there remains a possibility that Lannan could make his next scheduled start after the All-Star Game.
Despite being allotted as much time as he needed to warm up, Ryan Mattheus seemed rattled by his early appearance in the game. He induced Mark Ellis to ground back to the mound, but double-clutched on the throw to second and only an apparently generous out call from Brian Knight gave the Nationals the second out of the inning. Mattheus was then called for a balk by home plate umpire Bob Davidson, which forced Helton home with the go-ahead run. That in turn was followed by an RBI single for rookie Cole Garner, which made the score 3-1 and was all the scoring Colorado would do or need.
The rest of the night was, for the most part, an exercise in futility by the Nats offense, beginning in the first inning, when they loaded the bases with nobody out against Jason Hammel on a Roger Bernadina double, a walk to Danny Espinosa and an infield single by Ryan Zimmerman. Hammel kept it together, allowing only a sacrifice fly by Michael Morse (which scored Bernadina to give Washington their early lead) before striking out Jayson Werth and inducing Rick Ankiel to pop out to second base. In the rest of his outing, Hammel faced 20 batters, and allowed just four of them to reach base (a walk to Espinosa in the third inning, a solo home run by Wilson Ramos that made the score 3-2 to Colorado, a two-out single to right by Werth in the sixth, and a single to right by Desmond in the bottom of the seventh that precipitated Hammel's removal).
Hammel's removal did not turn the tide in Washington's favor. With newly-recalled Jesus Flores pinch-hitting in the seventh inning against Matt Reynolds, Desmond was picked off and caught trying to steal second. And the offensive ineptitude reached its climax in the 9th inning after a leadoff single by Morse. After Werth struck out flailing wildly at a pitch in the dirt, pinch-runner Brian Bixler, seeing the ball get away briefly from catcher Chris Iannetta decided to try to scamper over to second base. Iannetta recovered the ball in plenty of time to throw out Bixler, and Ankiel's swinging strikeout ensured that the Nats would drop back to the .500 mark entering the final weekend of the season's first half.
Tags: Brian Bixler, Colorado Rockies, Danny Espinosa, Ian Desmond, Jayson Werth, John Lannan, Michael Morse, MLB, Rick Ankiel, Roger Bernadina, Ryan Mattheus, Ryan Zimmerman, Washington Nationals, Wilson Ramos
Fun & Games, Sports Fix, The Features
Werth's Hustle Starts Holiday Party as Nats Beat Cubs 5-4 in 10
'Jayson Werth, where is you're head at?!?'
courtesy of 'Tony DeFilippo'
Jayson Werth, the focus of so much agonized discussion among Washington Nationals fans over the last few weeks, didn't get the big hit in this 4th of July thriller. But he did score the winning run, drove in two more, walked twice, and helped cut down a runner at the plate as the Nationals scrambled back to the .500 mark, defeating the Chicago Cubs 5-4 in 10 innings in front of most of an announced crowd of 32,937 at Nationals Park.
Washington's winning sequence was classic National League baseball. After Werth worked a walk off losing pitcher Marcos Mateo, he was bunted over to 2nd base by pinch-hitter Livan Hernandez. Hernandez was actually the second pitcher to pinch-hit in the game as Nationals manager Davey Johnson was forced to creatively manage his shortened bench in the absence of Michael Morse (hairline fracture of the forearm). After Mateo was forced to depart with an injury in favor of Carlos Marmol, Werth caught the Cubs infield defense napping and stole third without even drawing a throw. Finally, when Marmol's 2-2 pitch slipped past Geovany Soto and bounced around the backstop, Werth raced home with the winning run.
It was the perfect end to an up-and-down day for the $126 million man. Werth's broken-bat single in the bottom of the first drove home Danny Espinosa and made the score 2-0, Washington. But Werth was also a supporting player in one of the worst defensive plays seen from the Nationals at any point in their history. Continue reading →
Tags: baseball, Chicago Cubs, Danny Espinosa, Ian Desmond, Ivan Rodriguez, Jayson Werth, Jordan Zimmermann, Kerry Wood, Laynce Nix, MLB, nationals, Roger Bernadina, Washington Nationals
Interviews, Life in the Capital, People, The Features
By Rachel Levitin 3:00 pm03 Sep 2010
Living in DC: The Nationals' Perspective
Nationals Park / Photo by Max Cook
If you're an outsider looking in then it's easy to paint each resident of the greater D.C. metropolitan area with a political brush. People living in Maryland, Virginia or D.C. know the District is widely regarded as being the epicenter of the American political spectrum.
In anticipation of Glen Beck's "Restoring Honor" rally at the end of August, We Love DC author Ben H. Rome emphasized that Washington's culture remains as diverse as its people. The interests of people who live here go beyond day jobs and politics. Living in D.C. is a catalyst for an active and intellectually stimulating lifestyle. Not only do the Washington Nationals know this, but they embrace it.
When they're not at Nationals Park or on the road, Nationals players take advantage of their new home.
"It's definitely a fun place to be. There's always a lot going on in this place whether it's professional teams or politically. There's always something you can pay attention to in the news. It's kind of the center of a lot of things so you always feel like you're in an important place," Nationals pitcher Craig Stammen said. Continue reading →
Tags: Craig Stammen, dc, John Lannan, lifestyle, Roger Bernadina, Tyler Clippard, Washington D.C., Washington Nationals


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Josh Berlo and Heidi Uebelhor Promoted In Irish Ticket Office
Duo assumes new roles in ticket office.
Notre Dame, Ind. – The University of Notre Dame Ticket Office announced today the hiring of Josh Berlo and the promotion of Heidi Uebelhor. Berlo assumes the position of ticket office systems manager, while Uebelhor is the new ticket office systems administrator.
In their new roles, Berlo and Uebelhor are responsible for managing all of the computer systems and programs utilized within the Ticket Office, including the Paciolan Ticketing System and Ticketmaster. In addition, they are responsible for conducting the annual alumni football ticket lottery and for the sale, printing and distribution of all tickets sold in conjunction with events held at Notre Dame Stadium, the Joyce Center and all of Notre Dame's athletic venues.
Berlo is a 1999 graduate of the University of Massachusetts and a current MBA candidate in the Mendoza College of Business at Notre Dame. He previously served as a ticket office assistant at Massachusetts and was both an intern and graduate assistant in the Notre Dame Ticket Office.
Uebelhor, a 1999 graduate of Notre Dame, served as a student-employee, the athletic department Y2K contact person and the ticket office coordinator before being promoted to her current position.
General Notre Dame Announces Student-Athlete Support Event
General Notre Dame Announces Winter Sports Attendance Policy
General Irish Once Again Top NCAA Academic Ratings


BajaMar, located in desirable Mata Grande/Mata Chica neighborhood,five miles north of San Pedro. House was completed in 2010 and boasts pristine white sand beach, private infinity fresh water pool which overlooks to barrier reef, 3rd story viewing deck, palapa with bar, with beverage cooler & grill, 4 kayaks for guests to enjoy, and a further outdoor kitchen with gas grill, wine fridge and seating for 10+.
If you would like to go ahead and make a booking for the house, we require a 50% deposit to take a reservation.
For reservations longer than 10 nights, long-term reservations, no refund at all is provided on that proportion of the deposit relating to the reservation in excess of 10 nights.


Dr. Nancy Allbritton, Professor and Chair, Joint UNC/NCSU Biomedical Engineering Dept.
3/23/2014 – Very exciting and very interesting show. It's few years old but still a great intro to the joint UNC/NCSU program and all the great research going on.