text:
The media chorus is singing a new song this week in its anti-tea party echo chamber. It goes something like this: The law-breaking anarchists who want to tear America down are somehow just like law-abiding tea partiers — who are working tirelessly to build America back up.
This boneheaded comparison reminds me of what has now become an oft-repeated political euphemism. In 1988, during a vice presidential debate, Democratic candidate Sen. Lloyd Bentsen said to his Republican opponent, Sen. Dan Quayle, "Senator, I served with Jack Kennedy, I knew Jack Kennedy; Jack Kennedy was a friend of mine. Senator, you're no Jack Kennedy."
So despite the risk of sounding cliché here, I say to the small band of misfits and anarchists now occupying Wall Street: I was one of tens of thousands of patriotic Americans who were there at the beginning of the tea party movement. I stood shoulder to shoulder with tea partiers all across this country. And you, who are occupying Wall Street and trying to tear America down, are no tea partiers.
The tea party movement started spontaneously from the rant of CNBC's Rick Santelli on Feb. 19, 2009. His words resonated with millions across the country, and his spontaneous call for a "tea party" spurred tens of thousands to action.
Within a week, in close to 50 locations across the country, almost 40,000 people turned out to protest the U.S. government's fiscal irresponsibility. By Tax Day in April 2009, the movement had grown to millions — and there were more than 850 peaceful, lawful protests across the nation attended by more than a million people.
The movement was organic, fast moving and had a cogent message: It's time for fiscal responsibility in government.
Tea party rallies have always felt like "parties" — and safe and clean ones at that. Unlike protesters in New York, I can find no reports of tea partiers being arrested, individually or en masse, at the thousands of tea parties across the country with millions of attendees that have taken place for years now.
We are not lawbreakers, we don't hate the police, we don't even litter. A quick glance at the TV reveals the sharp contrast to the Wall Street occupiers.
In recent days, I've been repeatedly asked by reporters, "Does the comparison now being made in the media between the tea party and the Wall Street protesters bother you?"
My answer is an unequivocal: "Hell yes, it bothers me."
It bothers me because it groups millions of patriotic tea partiers, who want to build America back up, together with a bunch of criminals who want to tear America down.
Read the rest of the article


Just in time for the theatrical release of Brave on June 22nd, Tollytots has brought Merida to shelves as a beautiful doll and she is ready for an adventure with your child.
Merida is a skilled archer and impetuous daughter of King Fergus and Queen Elinor. Determined to carve her own path in life, Merida defies an age-old custom sacred to the uproarious lords of the land.
Merida's actions inadvertently unleash chaos and fury in the kingdom, and when she turns to an eccentric Witch for help, she is granted an ill-fated wish. The ensuing peril forces Merida to discover the meaning of true bravery in order to undo a beastly curse before it's too late.
The details of Merida's eyes, dress, and the beautiful red fiery curls in her hair really make this doll a special piece.
Disney Princess Merida is recommended for children ages 3+. Though Andrea isn't old enough to appreciate this doll, she will be loved by a little girl friend of Andrew's.
When she was over here earlier in the week and saw Merida arrive at our door, her comments were "She is so pretty! I want her!" We are excited to see a screening of Brave this week and I just know that we will love it as much as Andrew's little girl friend loves this doll.
Giveaway Rules: Contest will end at 11:01pm CST on July 10th, 2012 when I will draw a winner at random using the Rafflecopter Random Selector.


text:
Hurricane Bertha - July 8-14, 1996
A tropical wave moved off the coast of Africa on July 1st. When located south of the Cape Verde
Islands on the 3rd, a circulation was noted on satellite imagery. By the 5th, a tropical depression
had formed in the central tropical Atlantic. Following a smooth path around the periphery of the
Bermuda High, it strengthened to hurricane force as it moved through the Leeward Islands on the
8th. The hurricane moved through the British Virgin Islands, bypassing the U.S. Virgin Islands
and Puerto Rico to the north. Below is a storm total rainfall graphic for Puerto Rico, which used
data provided by the National Climatic Data Center in Asheville, NC.
Bertha became a major hurricane that night, while turning northwestward, paralleling the Bahamas
and the coast of Florida. Landfall was made on North Carolina on the 12th as a category two
hurricane. It tracked just inland of much of the Eastern Seaboard, before becoming extratropical on
the 14th while over the Maritime Provinces of Canada. The graphic below, supplied by Wes Junker,
shows how Bertha was already undergoing extratropical transition as it was moving by
the Mid-Atlantic states.
Its track, provided by the National Hurricane Center, is below.
On the graphic below is the storm total rainfall for Bertha. Note the streak of heavy rain
along its track until the 13th, when the heavier rains shifted to the west of the center. Topography
played somewhat of a role in this shift, but the extratropical conversion of Bertha was mainly
to blame.
Below is the calendar for Daily Precipitation Maps. Note that the 24-hour periods end

redpajama_set_name: RedPajamaCommonCrawl


text:
next anti-mutant character >
< previous anti-mutant character
Friends of Humanity
Religion: anti-mutant
Name: Friends of Humanity
Other Names: FOH; F.O.H.
Classification: villains group
First Appearance: The Uncanny X-Men (vol. 1) #299 (Apr. 1993): "Nightlines"
Creators: Scott Lobdell, Brandon Peterson, Dan Panosian
Ally: Graydon Creed
Type of Organization/Group: terrorist
Note: anti-mutant group founded by Graydon Creed
Number of group members listed below: 13
(Click links for info about character
and his/her religious practice, affiliation, etc.)
Team(s)
app.
Bastion (Sebastion Gilberti)
anti-mutant A.I.
Friends of Humanity; Humanity's Last Stand...
Operation: Zero Tolerance; Purifiers
[mystical fusion of Master Mold and Nimrod] 95
Friends of Humanity (anti-mutant)
Friends of Humanity 1
Graydon Creed
anti-mutant
Friends of Humanity (leader); Purifiers...
The Upstarts
[son of Sabretooth and Mystique] 61
[anti-mutant group founded by Graydon Creed] 20
Hanratty
Rachel Mostel
Jewish; Friends of Humanity (anti-mutant)
Friends of Humanity Byron Preiss Multimedia, etc. 1
Paul Stacy
hates Spider-Man; temporarily in anti-mutant Friends of Humanity
[cousin of Gwen Stacy; former mentor of Peter Parker] 22
W. C. Taylor
Donovan Zane
[led Empire State University FOH chapter] 4
The Uncanny X-Men (vol. 1) #299 (Apr. 1993): "Nightlines"
X-Factor (vol. 1) #106 (Sep. 1994): "Phalanx Covenant: Life Signs, Part 1" (cameo)
X-Factor (vol. 1) #119 (Feb. 1996): "The Best Offense" (cameo)
X-Factor (vol. 1) #127 (Oct. 1996): "Darker Destiny"
- http://en.wikipedia.org/wiki/Friends_of_Humanity
- http://www.comicvine.com/friends-of-humanity/65-40563/
- http://marvel.wikia.com/Friends_of_Humanity
- http://www.marvunapp.com/master/frffrz.htm


text:
package com.gs.fw.common.mithra.test.domain;

public class AllTypesIq
extends AllTypesIqAbstract
{
	public AllTypesIq()
	{
		super();
	}

/* for testing only. equals should not be implemented like this for production code*/
    public boolean equals(Object obj)
    {
        if (this == obj)
        {
            return true;
        }
        if (!(obj instanceof AllTypesIqAbstract))
        {
            return false;
        }

        final AllTypesIqAbstract allTypesIqAbstract = (AllTypesIqAbstract) obj;

        return !this.zGetNonTxData().changed(allTypesIqAbstract.zGetNonTxData());
    }

    public int hashCode()
    {
        return this.getId();
    }
}

redpajama_set_name: RedPajamaGithub


Today Philips Lumileds introduces LUXEON TX emitters, which deliver high luminous flux and maximum efficacy for a variety of directional and omnidirectional lighting applications. "These emitters are truly transformative in that they enable customers to achieve performance metrics -- such as a true 50W equivalent MR16 lamp at 2700K that meets ERP/DIM2 requirements -- which LEDs simply could not meet previously," said Kathleen Hartnett, Product Line Director for Emitters at Philips Lumileds.
"We use the term 'extreme efficacy' because of the remarkable performance customers can expect from these emitters," said Hartnett. "For instance, outdoor fixture manufacturers who need 4000K at 70 CRI are taking advantage of the LUXEON TX 360 lm output 1.0A and 85˚C to decrease overall system cost, but have the ability to drive the same part 350mA to deliver 155 lm/W LED efficacy and enable streetlights with a system efficacy of more than 120lm/W.
The LUXEON TX platform is available in a range of CCTs and CRIs to satisfy the most exacting requirements of downlights, high bay and low bay lighting, indoor area lighting, outdoor lighting and replacement lamps. In addition, for improved design flexibility, Philips Lumileds has added a minimum 85 CRI option so designers can further differentiate their product lines.
For applications that require a minimum 90 CRI, LUXEON TX delivers up to 100 lm/W warm white light (3000K CCT, 90 CRI and 700 mA at 85˚C).This level of efficacy at 90 CRI enables superior performance for luminaires that must adhere to increasingly stringent lighting standards such as the CEC's California Quality LED Lamp Specification.


text:
Harleston Magpies Men's first team secure promotion to National League despite defeat to Bedford
By Liam Apicella
liam.apicella@iliffepublishing.co.uk
It may not have been the way they wanted to get the job done, but Harleston Magpies Men's first team sealed promotion to the National League on Saturday.
Second-placed Magpies made the trip to Bedford knowing that a victory would seal them a place in the East Men's League Premier A top four and subsequently elevation to a higher standard for the 2019/20 campaign.
But they ended up falling short at Bedford, going down 4-3 at the home of their fellow promotion chasers.
Weybread, Suffolk, UK, 27 October 2018..Hockey action from Harleston Men's 1 v Cambridge University...Picture: Mark Bullimore Photography. (7630064)
However, results elsewhere went in Magpies' favour, meaning they have completed their pre-season objective with three matches left to spare.
Team manager Kevin Ridley said: "It is not the way we wanted to get it finished but results went our way and we will take it.
"It was a close and physical game at Bedford – the sort of game we are going to get more of next season.
"A draw probably would have been a fair result but it was not to be.
"It has been a good season all round and everyone wants to play at a higher level. The team spirit has been great and the players really deserve the promotion."
Magpies return to home comforts tomorrow when relegation-threatened Norwich City I will be their visitors (3pm).
Promotion may have been sealed, but Ridley does not want to see the season peter out.
"We do not want to finish on a losing note or by switching off," he added. "The game against Norwich is a big one for the club because it is a derby and a lot of our sponsors will be attending, so we want to put on a show.
"We are already looking ahead to next season and part of those plans is to make sure we finish on a high this year."
While player arrivals and departures during the off-season are inevitable, Ridley believes that Magpies will be competitive at a higher level.
"You are always looking for players that can improve the squad," he said. "Losing players happens and we could have one or two going to university or moving because of their jobs.
"But on the flip side we might get some of our former youth players back from university and we will also look to youth players we currently have at the club.
"As long as we put in the type of performances we have this season there is no reason why we will not compete with the sides in the National League."
Against Bedford it was Magpies who opened the scoring when Tom Ridley struck, but they were pegged back before the break with two goals by the hosts.
Parity was restored shortly after the restart when Dave Gilbert finished off a smartly-worked short corner routine.
More sloppy defending allowed Bedford to get their noses back in front, but once again Magpies regained their composure to draw level at 3-3 thanks to Ridley's second goal of the contest.
However, the home team scored a fourth goal from a penalty stroke seven minutes from time, and this time there was no reply.


text:
We Are Vertex
Voices of Vertex
Collaborations & Partnering
Stories & Updates
Investigational Medicines (Pipeline)
Become a Vertex Investigator
Our Approved Medicines
Guidance & Patient Support (U.S. Only)
Our Focus On Value
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Understanding CF
Voices of CF
Our Advances in CF
Vertex CF Community & Grant Programs
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Grants & Funding Opportunities
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The Vertex Foundation
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Approved Medicines
Results From Phase 3 REALIZE Study Showed Telaprevir-Based Therapy Significantly Improved SVR (Viral Cure) Rates in People Whose Prior Treatment For Hepatitis C Was Unsuccessful 40.6 KB
Results From Phase 3 REALIZE Study Showed Telaprevir-Based Therapy Significantly Improved SVR (Viral Cure) Rates in People Whose Prior Treatment For Hepatitis C Was Unsuccessful
- All major subgroups achieved significantly higher viral cure rates with telaprevir-based therapy compared to pegylated-interferon and ribavirin: 86% vs. 24% in prior relapsers, 57% vs. 15% in prior partial responders and 31% vs. 5% in prior null responders -
- No clinical benefit was observed in delaying telaprevir therapy by four weeks (lead-in) compared to starting telaprevir, pegylated-interferon and ribavirin simultaneously -
- Safety and tolerability results were consistent with prior Phase 3 studies of telaprevir -
BERLIN--(BUSINESS WIRE)-- Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced final results from its pivotal Phase 3 REALIZE study that evaluated people with genotype 1 chronic hepatitis C whose prior treatment with pegylated-interferon and ribavirin was unsuccessful either because they relapsed, had a partial response or had a null response. Data from the study showed that people in each of these subgroups who were treated with telaprevir-based combination therapy achieved superior rates of sustained viral response (SVR, or viral cure) compared to those treated with pegylated-interferon and ribavirin alone.
REALIZE also evaluated whether viral cure rates could be further improved by delaying the start of telaprevir by four weeks, during which time patients received four weeks of pegylated-interferon and ribavirin alone (lead-in), compared to a simultaneous start. The data showed no clinical benefit to a lead-in for people treated with telaprevir-based combination therapy. Safety and tolerability results were consistent with results from the prior Phase 3 studies of telaprevir. These data were presented today at The International Liver Congress™ 2011, 46th annual meeting of the European Association for the Study of the Liver (EASL) in Berlin, Germany. REALIZE was conducted by Vertex's collaborator, Tibotec BVBA.
"Patients with chronic hepatitis C who undergo re-treatment with currently available medicines rarely achieve a viral cure and remain at an increased risk for advancing to more serious liver disease," said Stefan Zeuzem, M.D., Professor of Medicine and Chief of the Department of Medicine at the JW Goethe University Hospital, Frankfurt, Germany and principal investigator for REALIZE. "These data are important because they showed that viral cure rates were three to six times higher for patients treated with a telaprevir-based regimen compared to re-treatment with currently available medicines."
Among those in the simultaneous start arm of REALIZE, 83 percent (121/145) of prior relapsers, 59 percent (29/49) of prior partial responders and 29 percent (21/72) of null responders achieved viral cures compared to 24 percent (16/68), 15 percent (4/27) and 5 percent (2/37), respectively, who received pegylated-interferon and ribavirin. The viral cure rates among those in the lead-in arm were 88 percent (124/141) among prior relapsers, 54 percent (26/48) among prior partial responders and 33 percent (25/75) among prior null responders. In a combined endpoint analysis of the two telaprevir-based treatment arms, 86 percent (245/286) of prior relapsers, 57 percent (55/97) of prior partial responders and 31 percent (46/147) of prior null responders achieved viral cures.
"The REALIZE results are encouraging, especially considering people in this study had been unsuccessfully treated in the past and many already had scarring of the liver," said Robert Kauffman, M.D., Ph.D., Senior Vice President and Chief Medical Officer for Vertex. "Rates of viral cure among those treated with telaprevir-based regimens were similar between the simultaneous and delayed start arms of the study, supporting the conclusion that there was no clinical benefit to a lead-in strategy with telaprevir."
In this study, 48 percent (316/662) of patients overall had advanced liver fibrosis or cirrhosis (scarring of the liver) and 89 percent (586/662) of patients overall had high amounts of hepatitis C virus (high viral load; HCV RNA ≥ 800,000 IU/mL) upon study entry.
Summary of REALIZE Results
REALIZE is the only Phase 3 hepatitis C study to date of a direct-acting antiviral medicine in development that was designed to evaluate people whose prior treatment was unsuccessful, including those who had a null response. In this study, patients were randomized 2:2:1 to two telaprevir-based treatment arms (simultaneous or lead-in) or a control arm of 48 weeks of pegylated-interferon and ribavirin alone. Patients in the telaprevir treatment arms received a total of 12 weeks of telaprevir-based combination therapy. In the lead-in arm, patients received four weeks of pegylated-interferon and ribavirin followed by telaprevir in combination with pegylated-interferon and ribavirin for 12 weeks followed by 32 weeks of pegylated-interferon and ribavirin alone. For those in the simultaneous start arm, the telaprevir-based combination was followed by an additional 36 weeks of pegylated-interferon and ribavirin alone. The primary endpoint of the REALIZE study was SVR in each of the two telaprevir treatment arms compared to the control arm and for the three groups of people included in the study. The total treatment time for all patients in REALIZE was 48 weeks.
SVR Results % (n) Prior Relapsers
(n=354)*
Prior Partial Responders
Prior Null Responders
TVR-based
Simultaneous Start Arm+
Lead-In Arm++
Control Arm+++
*The SVR rates observed were statistically significant when compared with the control arm (p
+Simultaneous start: 12 weeks of telaprevir (750 mg, q8h), Pegasys® (PEG, pegylated-interferon alfa-2a) & Copegus® (RBV, ribavirin), followed by 36 weeks of PEG & RBV alone.
++Lead-in: 4 weeks of PEG & RBV alone followed by 12 weeks of telaprevir (750 mg, q8h), PEG & RBV, followed by 32 weeks of PEG & RBV alone. There was no clinical benefit with the use of a four-week lead in with no significant improvement in SVR rates and no significant reduction in virologic failure and relapse rates in the lead-in start arm compared to the simultaneous start arm.
+++Control: 12 weeks of placebo, PEG & RBV, followed by 36 weeks of Peg & RBV alone.
Prior Relapser: Defined as a person whose hepatitis C virus was undetectable at the completion of at least 42 weeks of a prior course of therapy but whose virus became detectable during the follow-up period.
Prior Partial Responder: Defined as a person who achieved at least a 2 log in10 reduction in HCV RNA at week 12, but whose hepatitis C virus never became undetectable by week 24 of a prior course of therapy.
Prior Null Responder: Defined as a person who achieved a less than 2 log10 reduction in HCV RNA at week 12 of a prior course of therapy.
Safety and Tolerability Information for the Phase 3 Studies of Telaprevir
The safety and tolerability results of the telaprevir-based combination regimens were consistent across the Phase 3 studies. The most common adverse events were fatigue, pruritus, nausea, headache, rash, anemia, flu-like symptoms, insomnia and diarrhea with the majority being mild to moderate. Rash and anemia occurred more frequently in the telaprevir-based treatment arms compared to the control group.
Rash was primarily characterized as eczema-like, manageable and resolved upon stopping telaprevir. More than 90 percent of rash was mild to moderate and primarily managed with the use of topical corticosteroids and/or antihistamines. Anemia was primarily managed by reducing the dose of ribavirin.
To optimize each patient's opportunity to achieve viral cure in the Phase 3 studies, sequential discontinuation of the medicines was recommended as a strategy to manage certain adverse events. This strategy allowed patients to continue on pegylated-interferon and ribavirin after stopping telaprevir. Discontinuation of all medicines due to either rash or anemia during the telaprevir/placebo treatment phase was 1 percent to 3 percent in the telaprevir treatment arms.
REALIZE was a pivotal Phase 3, randomized, double-blind, placebo-controlled, global study. The majority of clinical trial sites were in Europe. The study was designed to evaluate the efficacy, safety and tolerability of telaprevir-based combination regimens in people infected with genotype 1 chronic hepatitis C who did not achieve a viral cure after at least one course of prior treatment with interferon-based therapy.
Status of Telaprevir Regulatory Applications
The regulatory applications for the approval of telaprevir have been granted Priority Review by the U.S. Food and Drug Administration (FDA) and Health Canada and accelerated assessment by the European Medicines Agency for the treatment of people with genotype 1 chronic hepatitis C. The FDA has scheduled its Antiviral Drugs Advisory Committee to discuss the New Drug Application for telaprevir on April 28, 2011. A target response date of May 23, 2011 is set under the Prescription Drug User Fee Act (PDUFA). The applications include data from three registration studies, ADVANCE, ILLUMINATE and REALIZE, which evaluated telaprevir in combination with pegylated-interferon and ribavirin in people with hepatitis C who were new to treatment as well as those who did not achieve a viral cure after treatment with currently available medicines. For complete information on the telaprevir clinical trials or a fact sheet on the trial designs visit: www.vrtx.com/press.cfm.
About the Telaprevir Development Program
Telaprevir is an investigational, oral inhibitor that acts directly on the HCV protease, an enzyme essential for viral replication. To date, more than 2,500 people with hepatitis C have received telaprevir-based therapy as part of Phase 2 studies and the Phase 3 ADVANCE, ILLUMINATE and REALIZE studies. Together, these studies enrolled people with genotype 1 chronic hepatitis C who had not been treated for their disease previously as well as people who had been treated before but did not achieve a viral cure.
Vertex is developing telaprevir in collaboration with Tibotec BVBA and Mitsubishi Tanabe Pharma. Vertex has rights to commercialize telaprevir in North America. Through its affiliate, Janssen, Tibotec has rights to commercialize telaprevir in Europe, South America, Australia, the Middle East and certain other countries. Mitsubishi Tanabe Pharma has rights to commercialize telaprevir in Japan and certain Far East countries.
About Hepatitis C
Hepatitis C is a serious liver disease caused by the hepatitis C virus, which is spread through direct contact with the blood of infected people and ultimately affects the liver.1 Chronic hepatitis C can lead to serious and life-threatening liver problems, including liver damage, cirrhosis, liver failure or liver cancer.1 Though many people with hepatitis C may not experience symptoms, others may have symptoms such as fatigue, fever, jaundice and abdominal pain.1 Approximately 60 percent of people who undergo treatment with an initial 48-week regimen with pegylated-interferon and ribavirin, the currently approved medicines for genotype 1 hepatitis C, do not achieve SVR,2,3,4 or viral cure.5 If treatment is not successful and a person does not achieve a viral cure, they remain at an increased risk for progressive liver disease.6,7
More than 170 million people worldwide are chronically infected with hepatitis C.5 In the United States, nearly 4 million people have chronic hepatitis C and 75 percent of them are unaware of their infection.8 The majority of people with hepatitis C in the United States were born between 1946 and 1964, accounting for two of every three people with chronic hepatitis C.9 Hepatitis C is the leading cause of liver transplantations in the United States and is reported to contribute to 4,600 to 12,000 deaths annually.10,11 By 2029, total annual medical costs in the United States for people with hepatitis C are expected to more than double, from $30 billion in 2009 to approximately $85 billion.9
PEGASYS® and COPEGUS® are registered trademarks of Hoffmann-La Roche.
Special Note Regarding Forward-Looking Statements
This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, including statements regarding (i) the date of the scheduled meeting of the FDA's Antiviral Advisory Committee and (ii) the FDA's target review date for the telaprevir NDA. While the company believes the forward-looking statements contained in this press release are accurate, there are a number of factors that could cause actual events or results to differ materially from those indicated by such forward-looking statements. Those risks and uncertainties include, among other things, that Vertex could experience unforeseen delays in obtaining approval to market telaprevir; that there may be varying interpretations of the data from the telaprevir clinical trials; that future outcomes from clinical trials of telaprevir may not be favorable; that future scientific, clinical, competitive or other market factors may adversely affect the potential for telaprevir-based therapy and the other risks listed under Risk Factors in Vertex's annual report and quarterly reports filed with the Securities and Exchange Commission and available through Vertex's website at www.vrtx.com. Vertex disclaims any obligation to update the information contained in this press release as new information becomes available.
Vertex creates new possibilities in medicine. Our team aims to discover, develop and commercialize innovative therapies so people with serious diseases can lead better lives.
Vertex scientists and our collaborators are working on new medicines to cure or significantly advance the treatment of hepatitis C, cystic fibrosis, epilepsy and other life-threatening diseases.
Founded more than 20 years ago in Cambridge, MA, we now have ongoing worldwide research programs and sites in the U.S., U.K. and Canada.
For more information and to view Vertex's press releases, please visit www.vrtx.com.
(VRTX - GEN)
1Centers for Disease Control and Prevention. Hepatitis C Fact Sheet: CDC Viral Hepatitis. Available at: http://www.cdc.gov/hepatitis/HCV/PDFs/HepCGeneralFactSheet.pdf. Accessed March 21, 2011.
2 Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet. 2001;358:958-965.
3 Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med. 2002;347:975-982.
4 McHutchison JG, Lawitz EJ, Shiffman ML, et al; IDEAL Study Team. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med. 2009;361:580-593.
5 Ghany MG, Strader DB, Thomas DL, Seeff, LB. Diagnosis, management and treatment of hepatitis C; An update. Hepatology. 2009;49 (4):1-40.
6 Morgan TR, Ghany MG, Kim HY, Snow KK, Lindsay K, Lok AS. Outcome of sustained virological responders and non-responders in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) trial. Hepatology. 2008;50(Suppl 4):357A (Abstract 115).
7 Veldt BJ, Heathcote J, Wedmeyer H. Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis. Annals of Internal Medicine. 2007; 147: 677-684.
8Institute of Medicine of the National Academies. Hepatitis and liver cancer: a national strategy for prevention and control of hepatitis B and C. Colvin HM and Mitchell AE, ed. Available at: http://www.iom.edu/Reports/2010/Hepatitis-and-Liver-Cancer-A-National-Strategy-for-Prevention-and-Control-of-Hepatitis-B-and-C.aspx. Updated January 11, 2010. Accessed March 21, 2011.
9 Pyenson B, Fitch K, Iwasaki K. Consequences of hepatitis C virus (HCV): Costs of a baby boomer epidemic of liver disease. Available at: http://www.natap.org/2009/HCV/051809_01.htm. Updated May 2009. Accessed March 21, 2011. This report was commissioned by Vertex Pharmaceuticals, Inc.
10 Volk MI, Tocco R, Saini S, Lok, ASF. Public health impact of antiviral therapy for hepatitis C in the United States. Hepatology. 2009;50(6):1750-1755.
11 Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings LW. Aging of hepatitis C virus (HCV)-infected persons in the United States: A multiple cohort model of HCV prevalence and disease progression. Gastroenterology. 2010;138:513-521.
Vertex Pharmaceuticals Incorporated
Dawn Kalmar
Amy Pasqua
Zachry Barber
617-444-6992 or mediainfo@vrtx.com
Michael Partridge, 617-444-6108
Lora Pike, 617-444-6755
Matthew Osborne, 617-444-6057
Source: Vertex Pharmaceuticals Incorporated
News Provided by Acquire Media
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Vertex creates new possibilities in medicine to cure diseases and improve people's lives. We work with leading researchers, doctors, public health experts and other collaborators who share our vision for transforming the lives of people with serious diseases, their families and society.
Tel +1(617)-341-6100
KALYDECO, the KALYDECO logo, ORKAMBI, the ORKAMBI logo, Vertex and the Vertex triangle logo are registered trademarks of Vertex Pharmaceuticals Incorporated.
SYMDEKO and the SYMDEKO logo are trademarks of Vertex Pharmaceuticals Incorporated.
All other trademarks referenced herein are the properties of their respective owners.
© 2017 Vertex Pharmaceuticals Incorporated | VXR-US-00-00270 | 04/2017


Top floor bungalow with Communal Pool and Tennis Court in Torrevieja.
Urb. Altos del LimonarEl Limonar- is a quiet and tranquil area in the surroundings of Torrevieja. Next to the natural park and only 4 km away from the beaches of Torrevieja and La Mata it's within walking distance to all kind of amenities and services, like restaurants, bars, supermarkets, pharmacies, a water park and a public clinic. It is the ideal location to enjoy the sun and commodities of living in Torrevieja but avoiding the noises and traffic of living in the center of the town.


text:
Woon Sze Mei (* 18. September 1977) ist eine malaysische Badmintonspielerin.

Karriere
Woon Sze Mei siegte 1998 und 1999 bei den Malaysia International, 2001 und 2002 gewann sie dort Silber. 1997 und 1999 nahm sie an den Südostasienspielen teil, 1998 an den Commonwealth Games und 1999 an der Badminton-Weltmeisterschaft.

Referenzen

Badmintonspieler (Malaysia)
Teilnehmer an den Asienspielen (Malaysia)
Malaysier
Geboren 1977
Frau
Teilnehmer an den Südostasienspielen (Malaysia)
Teilnehmer an den Commonwealth Games (Malaysia)

redpajama_set_name: RedPajamaWikipedia


text:
Carrier Capacity Solutions: Is Truck Driver Shortage The Only Problem?
TruckFreighter.com > Carrier Capacity Solutions: Is Truck Driver Shortage The Only Problem?
[vc_row][vc_column][vc_video link="https://www.youtube.com/watch?v=Eyc62kc3g_8″][vc_column_text]With the average age of truck drivers in North America being around 50 years old, it is clear to see that the entrance of a younger group of operators is lacking in the industry. There are many reasons why this can occur. Firstly, the trucking industry bears a lifestyle that may not be of appeal to younger drivers. For example, many semi-trucks are still equipped with manual transmissions which require a significant skill set to operate given most consumer cars have automatic shifting. Other reasons are perhaps due to market regulations such as the ELD mandate and the growing innovation to develop self-driving trucks.
While a truck driver shortage is one reason factoring into truckload carrier capacity issues, there are many other problems that affect the ability for a motor carrier to supply adequate equipment and manpower to haul freight across continental North America.
What it Means for Shippers
While there are a number of shippers who operate their own private fleet of trucks, many shippers work with asset-based logistic companies for the transportation of their goods. The concentration of certain types of trucking companies in particular areas of the U.S. and Canada also plays a role in why some shippers have trouble finding carriers to haul their loads. For instance, in the summer California often experiences a lack of reefer trucks to haul the abundant amounts of produce being hauled throughout the continental United States. Moreover, demands with narrow pickup/delivery appointments can lead to potential delays when shipping. Additionally, many shippers choose to work with larger carriers that have a large equipment fleet so that the extra volume can be leveraged for more competitive rates. The shippers that don't work with large carriers such as Schneider National, opt for third-party logistics providers also called freight brokers. Where does this leave carriers with capacity issues?
Carrier Capacity
The above-mentioned circumstances are just some of the challenges faced by shippers that result in lost business for many carriers. As a business grows, it is not always economical to invest in expensive new equipment, but leveraging your existing infrastructure and outsourcing to an interline carrier is one way to benefit.
Much will be discussed to increase carrier capacity in order to meet shipper demands. And while disadvantages will be discussed, the focus will be on finding solutions to those disadvantages to curb the capacity shortage.
Interline carriers
Interline carriers are transportation companies that move freight for other, often larger carriers. The party that outsources the loads is an asset-based freight broker. An asset-based freight broker does not need to have all of the required equipment needed to move a load in place. Rather, they usually have much of the infrastructure already, but use the services of another carrier to facilitate the transportation. For example, a warehousing/ distribution centre company may entirely use third-party interline carriers to move cargo. Another scenario can be when an established trucking company with enough trailers but a shortage of bobtails accepts the services of a carrier which can provide just the tractor(s).
Even though more than one company are involved in transporting the freight, the original carrier is the one who sends the freight charges to the customer.
Listed below are the advantages and disadvantages (with solutions) of working with interline carriers.
Insurance claims fall under the liability coverage of the contracted inter-line carrier as long as the damage was caused by them.
Driver infractions do not affect the asset-based carrier brokering the load given the interline company is operating under its own authority.
Lower operating expenses including equipment maintenance cost.
Acquire instant scale without a costly expansion plan that otherwise would take longer to execute.
Skip the costs associated with trial-and-error execution and utilize a business system that has been proven successful already.
Gain access to the future investments including any truck equipment that your outsourced provider makes.
Loading, unloading, cross-docking or other similar activities are not considered freight interlining and therefore require a broker authority under the updated FMSCA legislation. Solution: Obtain broker authority or freight should be transported by the original carrier at one point in the logistical chain. See: Can a motor carrier broker freight for further information.
Branding of truck or trailer. Solution: Consider having interline carrier haul loads during the night when traffic and visibility of brand signs and logos are already on the lower end of the scale.
Can a motor carrier broker freight?
A motor carrier can "broker" freight in the United States without a broker authority in certain circumstances. Freight interlining is permitted as long as the original carrier physically transports the load at one point in time. However, the issue arises from a liability standpoint. While many carriers once accomplished the brokering of freight without a broker authority, this practice has now been prohibited by Map 21. The Carmack Amendment holds motor carriers liable for freight claims so in instances where a clear corporate distinction is not made between the operation of a carrier and broker, then liability issues can arise. A recommended solution, in addition to establishing a strong corporate structure by creating separate legal brokerage and carrier entities, is to have a contract in place that defines the original carrier's role as either a broker or carrier at different points in the transportation processes. For more information, we suggest you refer to the following links and contact a legal professional to find an answer best suited to your situation.
http://www.smithmoorelaw.com/TNLBrokerCarrier
http://www.hni.com/blog/bid/84213/faqs-about-the-carmack-amendment
The provinces of British Columbia, Alberta, Saskatchewan, Manitoba, Nova Scotia, New Brunswick, Prince Edward Island, and Newfoundland do not regulate freight brokerage. The territories of Yukon, Nunavut, and the Northwest territories also do not regulate freight brokerage.
For more information read freight broker Canada regulations.
The usage of interline carriers can be an effective method to curb both less-than-truckload and full-truck load carrier capacity shortages.[/vc_column_text][/vc_column][/vc_row]
DEF Refractometer


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Q: Compare an object's value with the value of enum I declare enum with a value assigned to each of them.
public enum RATING {
   G(0), P(12), M(16);
   private int age;

   private RATING(int age){
   this.age = age;
   }
}

I want to do something like this, but it doesn't compile.
... if (Customer.getAge() >= Film.getRating()) ...

Customer.getAge() returns an int;
Film.getRating() returns a enum RATING
How can I compare an object's value with the value of enum?

A: At this point, you are not comparing it to the value of the enum, but with the enum itself.
Change your enum like this:
public enum RATING {
   G(0), P(12), M(16);
   private int age;

   private RATING(int age){
   this.age = age;
   }

   public int getAge(){
    return this.age;
    }
}

and compare like this:
if (Customer.getAge() >= Film.getRating().getAge())

A: Add to your enum this method
 public int getAge(){
   return age;
   }

and modify the code
if (Customer.getAge() >= Film.getRating().getAge()) ..

A: Add the following method to RATING:
public int getAge() {
    return age;
}

And then you can use the following line:
if (Customer.getAge() >= Film.getRating().getAge())

redpajama_set_name: RedPajamaStackExchange


text:
Girlpool announce new album, What Chaos Is Imaginary, share "Hire": Stream
Plus, the duo announces a lengthy North American tour with support from Hatchie
by Zac Gelfand
Girlpool, photo by Ilana Kozlov
A year and a half after releasing their critically acclaimed sophomore album, Powerplant, Los Angeles indie rock duo Girlpool have announced a new record called What Chaos Is Imaginary. Set for release February 1st, 2019, the LP is the result of years spent fine-tuning the craft of creating music in a digital world.
Harmony Tividad and Cleo Tucker have finessed their songwriting abilities both together and on their own through several Girpool releases as well as their solo work. Once restricted to writing "hand in hand," they now give themselves space to trust their own skills before coming together. "It's helped me find validity in parts of my writing I found to be unapproachable," Tividad says of the duo's process. "I thought my stream-of-consciousness was unsophisticated."
Ever-evolving as songwriters has led to each album being a snapshot of a band in the midst of evolution, and What Chaos Is Imaginary is Girlpool's biggest leap yet. The effort still features Girlpool's signature guitar swells, but where their previous two albums were comprised mostly of guitar-bass-drum rock sounds, this one also features a more experimental approach: drum machines, synthesizers, and orchestral interludes from a string octet represent the latest development in the band's expanding musical voice.
With two singles already released in the form of "Where You Sink" and "Lucy", the band has accompanied the announcement of What Chaos Is Imaginary with "Hire", the album's third single. Stream all three tracks below.
What Chaos Is Imaginary is available to pre-order now via Anti- Records. Check out the album artwork and track listing below, along with newly announced tour dates with Hatchie.
What Chaos Is Imaginary Artwork:
What Chaos Is Imaginary Tracklist:
01. Lucy's
02. Stale Device
03. Where You Sink
04. Hire
05. Pretty
06. Chemical Freeze
07. All Blacked Out
08. Lucky Joke
09. Minute In Your Mind
10. What Chaos Is Imaginary
11. Hoax And The Shrine
12. Swamp And Bay
13. Josephs Dad
14. Roses
Girlpool 2019 Tour Dates:
04/04 – Tustin, CA @ Marty's On Newport *
04/05 – San Diego, CA @ The Casbah *
04/06 – Los Angeles, CA @ The Regent Theater *
04/09 – San Francisco, CA @ The Independent *
04/11 – Portland, OR @ Wonder Ballroom *
04/12 – Seattle, WA @ Neumos *
04/13 – Vancouver, BC @ Biltmore Cabaret *
04/16 – St Paul, MN @ Turf Club *
04/17 – Madison, WI @ High Noon Saloon *
04/18 – Chicago, IL @ Lincoln Hall *
04/19 – Ann Arbor, MI @ Blind Pig *
04/20 – Toronto, ON @ Longboat Hall *
04/21 – Montreal, QC @ Bar Le Ritz *
04/23 – Boston, MA @ Royale *
04/24 – Brooklyn, NY @ Music Hall of Williamsburg *
04/25 – New York, NY @ Bowery Ballroom *
04/26 – Philadelphia, PA @ Underground Arts *
04/27 – Asbury Park, NJ @ Asbury Lanes *
04/28 – Washington, DC @ Black Cat *
04/30 – Durham, NC @ Motorco Music Hall *
05/01 – Athens, GA @ 40 Watt *
05/02 – Birmingham, AL @ Saturn *
05/03 – Baton Rouge, LA @ Spanish Moon *
05/04 – Houston, TX @ Satellite *
05/05 – San Antonio, TX @ Paper Tiger *
05/07 – Austin, TX @ Mohawk *
05/08 – Dallas, TX @ Club Dada *
05/09 – Oklahoma City, OK @ 89th Street Coop *
05/10 – Santa Fe, NM @ Meow Wolf *
05/11 – Tucson, AZ @ 191 Toole *
* = w/ Hatchie
Album Announcement
Album Artwork
Best Indie Rock
Chris Cornell's son stars in video for late rocker's song "When Bad Does Good": Watch a preview
Stan Lee still has at least two cameos left in the Marvel Cinematic Universe


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Jimmy Kimmel's wife opens up about their family drama
As a writer and producer on "Jimmy Kimmel Live!" as well as Kimmel's wife, Molly McNearney should have been the first...
Posted: Dec 7, 2017 6:01 PM
Updated: Dec 7, 2017 6:01 PM
As a writer and producer on "Jimmy Kimmel Live!" as well as Kimmel's wife, Molly McNearney should have been the first to know about his moving monologue about their son's health issues.
McNearney told the Hollywood Reporter that while she was on maternity leave with their newborn son William (whom they call Billy), she was still receiving work email in May when she noticed she hadn't received one about that night's monologue.
McNearney said she cried watching Kimmel's monologue
She looks forward to being able to tell their son about what his father did
Instead her husband told her "I just want you to watch."
"So, there I am, in my living room breastfeeding Billy with my mom beside me, and we're watching," she said. "I sobbed through the entire thing. I couldn't believe the strength that it took to tell that story a week after it happened."
Kimmel had tearfully talked of Billy's birth on April 21 with a serious heart issue and used it as a plea to ensure that healthcare in this country was affordable for everyone.
The newborn had open-heart surgery a few days after he was born and this week had a second successful surgery.
Related: Jimmy Kimmel's son has 'successful heart surgery'
Kimmel has used his experience as the parent of a sick child to become one of the most high-profile advocates in the health care debate.
His wife is now reflecting on why he felt the need to dive into the political hotbed.
"Our family has excellent health care; he had nothing to gain from that," she said. "He did it for the other people whom we met in that hospital. He came home that night, and I just hugged him and I wouldn't let go."
McNearney said the response has been overwhelming with strangers continuing to come up and thank Kimmel for his monologue.
But there has also been the backlash, she said, with accusations of their "politicizing" their baby's health crisis.
"We took a personal experience and we shared it with the world, and then it just so happened that this was going on while people were trying to take health care away from children like ours," McNearney said. "People were sending letters to our home, attacking both of us on Twitter, saying things like we deserve this and we're terrible people."
And while she said she's not thrilled with the lack of privacy which comes with their being so public about their child's health, McNearney feels it's worth it to help others.
She also reiterated her pride in Kimmel.
"I'm looking forward to the day that I get to tell [Billy] about all of this," she said. "I want to be the one to tell Billy what his dad did for him."
Ellen DeGeneres surprises Jimmy Kimmel
Stormy Daniels appears on Jimmy Kimmel
Jimmy Kimmel explains Fergie anthem performance reaction
Why Jimmy Kimmel wants Oprah's Twitter password
Jimmy Kimmel leaves Kanye West speechless
Jimmy Kimmel gives virgin 'Bachelor' the talk
Why Jimmy Kimmel isn't writing his Oscar jokes yet
Stormy Daniels talks (and doesn't talk) Trump with Jimmy Kimmel
Jimmy Kimmel brings new political profile to Oscar-host role


text:
Moehringia lateriflora, commonly known as the bluntleaf sandwort, is a plant species native to Europe, Asia, the northern United States and most of Canada. It has been reported from every province and territory in Canada except the Northwest Territories, as well as every state in the northern half of the US, including Alaska, plus New Mexico and from Saint Pierre & Miquelon. It is also reported from Russia, China, Korea, Mongolia, Japan, Kazakhstan, Finland, Sweden, Norway, Latvia, Estonia, Belarus, Ukraine.

Moehringia lateriflora is a perennial herb spreading by means of underground rhizomes, often forming large colonies. Aerial stems are up to 30 cm long, covered with retrorse (pointing down toward the base of the stem) hairs. Leaves are broad, up to 35 mm long. Flowers occur singly or in groups of 2–5. Petals are white, up to 6 mm long, generally twice as long as the sepals.

References

lateriflora
Flora of the United States
Flora of Canada
Flora of Russia
Flora of Saint Pierre and Miquelon
Flora of China
Flora of Korea
Flora of Japan
Flora of Kazakhstan
Flora of Mongolia
Flora of Europe
Taxa named by Carl Linnaeus


The Steamship Authority's vision is to do what it has always done, as it has always done it, to do it where it has always done it, to do more of it, and to deflect efforts by its transportation partners in Vineyard Haven and Woods Hole that might lead it to consider new strategies in new places.
The real imaginative opportunity is to find a way to flush the Bernier poison pill and allow the lot to be sold by IHT for commercial purposes (parking perhaps) — but not to Stop & Shop, if Mr.
The Martha's Vineyard Public Charter School student brings a new perspective to old camera technology.
Christmas decorations, gifts, and luncheon items at the Annual Christmas Fair.
Holiday shopping, parades, parties, and art installations on December 7.
It's hard to compete with silver tinsel and shiny new sleds.
The Season's Greetings Dance Extravaganza, the annual holiday show of RISE Vineyard Performing Arts, will take place on Sunday, December 8, at the Oak Bluffs School Auditorium.
A winter feast helps a student garden grow.
MVRHS students will prepare feast to benefit their school garden, tonight.
Go Slo Potluck on Sunday will draw attention to endangered local foods.
Island author asks: what would you do, if the world was ending in one week?
Parry mentioned a wind facility located near a dairy farm in Glenmore, Wisconsin where the farmer reported reduced milk production from his cows after the turbines went up.


text:
This directory contains unmodified benchmarks from the paper [Hoard: A
Scalable Memory Allocator for Multithreaded Applications](http://doi.acm.org/10.1145/378993.379232 "Hoard").

* Original repository: https://github.com/emeryberger/Hoard
* Licensing: GPLv2 (see `LICENSE.hoard` for terms)


The woods and meadows in Val Fiorentina are plenty of mushrooms. Here you can find chanterelles, porcini mushrooms, parasol mushrooms and lots of other varieties.
You can pick mushrooms along the trails of the valley, among pines and larches, with a regular permit.
Before going mushroom hunting, we suggest you to read the regulation (regolamento_di_raccolta_funghi) and some advices about mushroom hunting and about the respect for woods (consigli_per_la_raccolta).
The mushroom picking permits can be purchased at the tourist office in Selva di Cadore.


text:
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Home Products — Memory Ram — Memory Flash — Hard Drives / SSD — Optical storage — Peripherals — Tablets — Monitors — Motherboards — Video Cards — Power Supplies — Drones — Point of Sale Support — RMA Center — Support Center Contact Us
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I looked around and saw nobody mentioning this, I think it would be super cool to have the ability to subtract shapes from the ones in the scene to further customize stuff (would work wonders with primitives) .
@nocheatcodes, are you talking about the shapes (objects) you drag into the editor?
Select the object and press "Delete."
If you mean parts of the objects, you'd need to create a custom obj.
I hope this helps and I'm not off base with my understanding of your suggestion!
I think he mean like in C4D or other 3d software than a shape carve in another.


All too often in Australian society "drink driving" is held up as the cause of the high road toll and deaths of young people on our roads. But there's a much deeper cause that most people don't want to look at: alcohol consumption and our attitudes around one of the most dangerous drugs there is.
We are currently considering petitioning the Australian Government on this critical issue. Please consider the following statements and decide if you would like to be involved in a petition to government to support a new policy around alcohol consumption in Australia.
Drink Driving is NOT the problem that needs fixing. Drinking alcohol itself is the problem in such instances.
According to the TAC: "If you drink drive you are a bloody idiot". It should also be the case: If you binge on alcohol, you are a bloody idiot. Our new suggested slogan is: "If you binge drink, your brain will shrink."
.05% is the limit for drink driving. .05% should also be generally the limit for drinking: .05% whether or not you drive.
"Drunk in Public" and "Drunk and Disorderly" are potential charges if you attract police attention over wrongdoing. However, you can drink till you reach alcohol-poisoning levels legally provided you are not casing any disturbance.
The perception of the community is that getting drunk is "ok" as long as you do it safely and don't drive. The law should change to reflect our concern over binge drinking and excessive use of alcohol. We see this issue as our "duty of care" as professionals and for those involved in political decision making processes on law changes.
We are recommending a change in legislation that makes it "illegal" to have a certain alcohol reading whilst in public as the person in question would be a danger to themselves or others. We would begin with an obviously unacceptable level of alcohol such as 0.15% or more.
There is a general agreement that such a level is unacceptable on many fronts: health (blackouts / brain damage / developing tolerance / addiction potential); legal (residual alcohol remaining in the system the following day, drink driving, work performance, absenteeism, hang overs etc.), and social / domestic problems.
We ought to begin this as a trial in order to evaluate its success in reducing outcome of potential accidents, legal and health problems.
The federal government is in a process of examining and / or considering a review over alcohol laws in Australia. Let us give them a guide to what is desperately needed.
As professionals in this field, if we continue allowing the same, we are hypocrites. Enough is enough.


text:
Évora de Alcobaça est une freguesia portugaise située dans le District de Leiria.

Avec une superficie de 42,32 km et une population de 4 788 habitants (2001), la paroisse possède une densité de 113,1 hab/km.

Municipalités limitrophes

Liens externes
  Site officiel

Freguesia au Portugal


retirement and pitch for the Astros next season.
last offer was for $39 million over three years.
important factor for the pitcher's wife and children.
of the Astros and the Houston fans."
start that he wanted to go home."
to be with his family. He couldn't do that in New York,"
Steinbrenner said. "He was a great competitor for me."
Pettitte, in fact, has been working out with Clemens.
"I don't know what he's thinking, but he's been working out with me all week and he's in shape," Pettitte told Dan Patrick on ESPN Radio. "He could pitch right now. I can tell you this ... if he expressed to me at all that he wanted to play, I would be all over him."
Pettitte went 21-8 with a 4.02 ERA last season.
Derek Jeter tried to convince Pettitte to stay in the Bronx.
"He called me a few days ago and yeah, he tried to talk me into staying," Pettitte told Patrick. "That's one of the hard parts, leaving great guys like him and a lot of others."
important pitching is to a successful baseball team."
With the Astros, he felt wanted.
[World Series] Game 6, I didn't think this would be a reality,"
He joins a team trying to rebuild and win at the same time.
Oswalt to form a powerful front three in the rotation.
And, the Astros are counting on Octavio Dotel to replace Wagner.
imagination did I think we really had a chance."
less than New York offered.
Pettitte won four World Series with the Yankees.
Karsay said. "It's going to be sad to see him go."
Clemens sounded surprised by the Yankees' bargaining.
have been able to sway him away."


text:
Q: Getting a ETA of a packet in Omnet++ I embedded the Omnet++ simulation kernel into my application and I'm using the inet framework for my simulation. The problem I'm having is that I need to estimate at witch time a packet is going to arrive at it's destination.
So more specific: There are two EtherHost, named H0 and H1 (inet.node.ethernet.EtherHost) and one EtherSwitch named switch (inet.node.ethernet.EtherSwitch), the three are connected like this:

H0 <-> C <-> switch <-> C <-> H1

C denotes a DatarateChannel with datarate = 100Mbps and delay = 0.1us. When the EtherAppCli in H0 sends a EtherAppReq to H1, I need to get a ETA on the EterAppReq packet during the transfer of said packet.
My first thought was to always get the encapsulating package of EtherAppReq, wich is added in the EtherLLC and EtherMAC module but this is not as simple as I thought.. I would need to change all the encapsulating functions in all the lower layers to always get a pointer to the encapsulating package, or am I wrong?
Or is there another way to get a ETA of a packet mid-transfer?
Edit: For my purpose I only need the arrival time at the next module, so if the packet is in the mac module of H0 I need the arrival time at the mac layer in the switch (So no multi module hops). Like when you have a cMessage you can call getArrivalTime() on the message and get a estimate of the arrival time if I'm not mistaken.
Thank you very much for the help in advance!

A: It is impossible to obtain ETA of a packet in advance. The time of packet's arriving depends on many factors (like in real network), for example: current number of packets in host's and switch's queues, processing time in switch, number of CPU of switch, processing time of MAC layer in a host etc. Therefore at the moment of sending a packet neither the host nor simulation environment do not know when this packet arrive a destination host. So we prepare a model and do a simulation in order to measure this time and learn how some factors influence it.
By the way: there is no H1 in your figure.


Agency Background: Literacy Connects was created in 2011 through the merger of five existing literacy organizations based in Pima County. Their vision is for literacy to be accessible and attainable for all, and that a more literate community will thrive economically, socially and culturally. Their major programs include: Reach Out and Read Southern Arizona which partners with doctors to prescribe books and encourage families to read together; Reading Seed helps children learn to read so they can read to learn; and Stories that Soar! A multi-faceted literacy and arts program which empowers youth by giving voice to their original words and creative ideas; Literacy Volunteers of Tucson teaches adults to read, write and speak English.
Focus of the 2013 SCCF Grant: Children's Programs:Funds will be used to support current direct programming expenses, such as printed materials, books, and orientation, training and support of volunteers. The amount requested represents 4% of the total budget for children's programs for fiscal 2012-2013.


I just really love to write about all God has shown me sbout who He is and what He has done. I want to use the creativity He has given me to glorify and honor Him. Also, along with others, I want to enjoy the gifts He has given me.
...For They Shall See God!!
See Ya at the Finish Line!!


Soccer prediction today and match preview for Nice vs Reims on 22nd April 2016 for the France Ligue One round 35 fixture.
Bookmakers offered a too low Asian handicap -1/2 for Nice hosting Reims at home on Friday evening and the early market has indicated that there are more support for a home win for this fixture.
Nice currently rank 4th on the French top soccer division with 54 points after 34 round of league matches played and Reims now rank 17th with 36 points coming into this game.
The home side has secured 10 points from its previous five league matches and the visiting team has picked up 4 points from its last five league games played at home and away.
Can Reims get any point away from home from this fixture?


text:
"Pretty Rosebud" Premiere Debut
Writer/Actress Chuti Tiu and Director/Actor Oscar Torre attend the premiere of Pretty Rosebud, Jan 16, 2015, at the Arena Cinema. Copyright 2015 Bourgeois Magazine LA
Jan 16, 2015, at the Arena Cinema marked the opening premiere of "Pretty Rosebud (2014)." The night opener started off with a high energy red carpet showcase, filled with notorieties from all walks of the entertainment industry. The red carpet was filled with a sea of photographer's and entertainment news personals capturing all aspects of "Pretty Rosebud (2014)" premiere. With smiles, hugs, greetings from event goers, "Pretty Rosebud (2014)" made a true statement of love and support for film Director/Producer/Actor: Oscar Torre and Writer/Producer/Actress: Chuti Tiu. Q&A was held after the movie screening to talk with Director/Producer/Actor: Oscar Torre and Writer/Producer/Actress: Chuti Tiu about their film. A standing ovation was felt throughout the room, which left a heartwarming smile from Oscar Torre and Chuti Tiu. After Q&A, an after-party took place at Sadie's Kitchen and Lounge, which guest got the chance to mingle and have a great time. Certainly, this high energy event made a true statement and reminder that every hard working filmmaker can bring out love and support for an unbelievable night.
Director/Actor Oscar Torre and Writer/Actress Chuti Tiu attend the premiere of Pretty Rosebud, Jan 16, 2015, at the Arena Cinema. Copyright 2015 Bourgeois Magazine LA
Director/Producer/Actor: Oscar Torre and Writer/Producer/Actress: Chuti Tiu are not only responsible for making "Pretty Rosebud (2014)," but are a real life husband and wife duo. Torre and Tiu certainly delivered a brilliant concept, with creative vision. Chuti Tiu was recently recognized for her achievements on "Pretty Rosebud (2014)" and received several awards from Action on Film International Film Festival, USA. Certainly, a statement in itself!
"Pretty Rosebud (2014)" takes you on a journey of Cecilia 'Cissy' Santos (Chuti Tiu) a career woman, battling a marriage on the verge of divorce, juggling family traditions through her parents eyes, and struggling through guilt from elements at hand from adultery. Phil Santos (Kipp Shiotani) is Cecilia's husband, whom has been dealing with the loss of work, lack of inspirational drive, detachment issues from Cecelia, and compulsive drinking. The relationship between Phil and Cecilia's has lost it's luster, passion, and motivation to stay connected. This seems to be a forever evolving crisis that eventually show's itself at the end.
Alejandro (Oscar Torre) is Cecelia's sparing couch and lover on the side. The relationship dynamic seems to be an open door for Cecilia, but it is not her true focus. Cecilia finds herself on this sexual conquest with several other men to satisfy her pain, but is consumed in guilt by what she has done. This element has forced Cecilia to face reality head on, which has exposed her to what is truly important in her life. Although, the brief interludes had temporary satisfaction for Cecilia, resolve was needed to change the course of her life structure all around. Only life purpose, choice, and possibility of letting go were the key fix at this point.
Cecilia's parents Dr. Crescencio Lam (Dana Lee) and Letty Lam (Bel Hernandez) worked very hard to illustrate the love and values instilled in their children, but this seems to not hold steady. Coming from a Filipino family of strict morals and religious beliefs, adultery or marriage outside of raise was not accepting within the Lam family. Many traditional values seem to take it's tole on Cecilia, which comes face-to-face down the line. Although, the elements that surrounded Cecilia and Phil seemed to be a very large concern to Mr. and Mrs. Lam they learned to grow practical of the dynamic's at hand.
"Pretty Rosebud (2014)" delivers a true core of self worth, and making peace within one's self on the road of life. Certainly, a well written and directed film body structure, which leaves viewers truly engaged throughout. "Pretty Rosebud (2014)" gets two thumbs up for this amazing film piece!!!!
"Pretty Rosebud (2014)" can be seen at the Arena Cinema, in Hollywood, Ca. For local listing times, go to http://arenascreen.com
To follow "Pretty Rosebud (2014)" on Facebook, go to https://www.facebook.com/prettyrosebudfilm
Red Carpet Attendees:
Director/Producer/Actor: Oscar Torre (Pretty Rosebud)
Writer/Producer/Actress: Chuti Tiu (Pretty Rosebud)
Kipp Shiotani (Pretty Rosebud)
Dana Lee (Pretty Rosebud)
Marco Martinez (Pretty Rosebud)
Gloria Laino (Pretty Rosebud)
Marco Martinez (Pretty Rosebud/ CSI)
Jennifer Aquino (Pretty Rosebud)
Producer Rebecca Hu (Pretty Rosebud)
Charles Rahi Chun (Scrubs)
Director: Greg Morgan (The Boatman)
Writers: Duke & Susan Addleman (The Boatman)
Carlos Gómez (Ride Along 2)
Emilio Rivera (Sons of Anarchy)
Celeste Thorson (joie Ride)
Robert Paul Taylor (Fox -News Girl)
Jonathan Stanton (CSI-Vegas)
Walter Tabayoyong (Marry Me/The Secret in Their Eyes)
Stephanie Gerard (Chemist)
Frankie Ray (The Brain)
Actor/Director Orestes Matacena and Producer Orna Rachovitsky
Actors George Halali and Marlene McCohen
Tara Lynn Orr and Phillip Brennickmeyer
This entry was posted on January 19, 2015 by bourgeoismagazinela in Bourgeois Magazine LA, Entertainment, Events, Film.
https://wp.me/pYicd-1pG


To the average person it might look like scientists operate in an ivory tower away from reality, which, can make engaging in scientific issues intimidating. To bridge this gap engaged citizens and scientists have launched themselves into the "citizen science" way of doing things. Basically what that means is that they're taking science to the streets.
Through Uprose and HabitatMap, another New York-based environmental justice organization, Gomez and a handful of other youth banded together to figure out exactly how much pollution the expressway was coughing into the neighborhood. "There are no entrances to the expressway in Sunset Par–just the exits," says fellow youth organizer Brian Gonzales. "So we're left with thousands of cars and trucks passing through every day." The exhaust from those cars–particularly particulate matter 2.5, which is so small that 60 particles lined up equal the width of a human hair–is especially pernicious. While larger particles may lodge in nose hairs or the back of the throat and never make it into the body, PM 2.5 passes deep into the lungs and eventually the blood. They cause short-term problems like asthma and bronchitis, and cancer and heart disease later.
They want to stabilize the change and, ideally, change the trajectory we're on.
It all started as an assumption that scientists cared, and they care a lot.
Polling opens for the Canadian election on October 9th with the final day to vote on the 19th. This election, the organization Evidence for Democracy (and many more!) are asking you to vote with science in mind.
Our project reflects the collective wisdom of 75 leaders — in science, indigenous knowledge, public policy, civil society, and governance — who are concerned about the erosion of an evidence-based approach to public policy decision-making in Canada.
The Ig Nobel Prize is dedicated to science that makes you laugh then makes you think. It's a fun and great way to get people engaged in science while exploring questions that sound rather bizarre.


text:
A Week's Look Back at the Turks
7/10/2007 – Turk Tidbits and VBL News
Harrisonburg (19-8 overall, 1.5 games back) The Turks went 4-2 last week, and fell back to 1.5 games behind league leader Waynesboro in the Valley League Standings. One of the two Harrisonburg losses game in a showdown of the top-two Valley League teams, as they lost 6-5 at Waynesboro. With the Turks leading 5-4 going into the bottom of the eighth, when newly signed reliever Josh Moore gave up two earned runs to pick up the loss for Harrisonburg. As a team Harrisonburg hit .292 with a league-leading six home runs and 34 RBIs. First baseman David Dennis led the way with a .455 batting average, including a double and two home runs. Dennis also added three RBIs and five runs scored for the Turks. Starter Rod Brantley started two games, going 1-0 with a 2.40 ERA. Brantley pitched 15 innings, striking out 12 while allowing four hits and four earned runs. Closer Garrett Parker picked up two saves in three appearances.


text:
Waterford County Museum, Dungarvan, Co. Waterford, Ireland. Charity Reg: 17397
Tel: +353 (0)58 45960 Email: info@waterfordmuseum.ie
Fenian Rising 1867
Irish Famine 1845 - 1852
Irish War of Independence 1919 - 1921
Alcock - Currey
De Hindeberg - Greatrakes
Hansard - Lynch
MacConmara - O'Siochain
Power - Ussher
Villiers Stuart - Wyse
Abbeyside
Cappoquin
Kilgobinet
Modeligo
Articles Photos
Successful Heritage Week Events at Museum
Aidan O'Hara Talk - Links Between Waterford & Newf...
Lecture On Chearnley's of Salterbridge House, Capp...
A Childs Day in the Big House
Children's Event for Heritage Week
Heritage Week Talks at Museum
Children's Events (53)
Opinion Piece (24)
Waterford History Network (268)
Aidan O'Hara Talk - Links Between Waterford & Newfoundland
Author Aidan O'Hara
When: 8pm Friday September 7th 2012
Venue: Town Hall Theatre, Dungarvan
Admission: €5
Waterford County Museum are delighted to welcome well known author, lecturer and film maker Aidan O'Hara to speak in the Town Hall Theatre on Friday September 7. Aidan O'Hara, has worked as a presenter and producer with RTÉ (Raidió Telefís Éireann - Irish National Broadcasting) and CBC (Canadian Broadcasting Corporation). Aidan is engaged in writing full-time, but stays in touch with broadcasting through his regular contributions to Radio Telefís Éireann and Raidió na Gaeltachta.
His biography on the legendary Delia Murphy,'I'll Live 'Till I Die' was highly acclaimed as was Aidan's story of the Irish in Newfoundland, Na Gaeil i dTalamh an Éisc, was published in 1998. His paper "The Irish in Newfoundland" was published in The Emigrant. He presented three acclaimed Radharc documentaries on the Irish of Newfoundland on RTE. He is currently writing a book on the Irish in the era of the American Civil War 1861-65, and his chapter, 'Judge Charles Patrick Daly (1816-99)' is due for publication next year in "Irish Soldiers - American Wars".
His is a keen historian with a special interest in the Irish emigration experience. Aidan is Chairman of the Emmet and Devlin Committee and co-founder of the Association of Canadian Studies in Ireland. Aidan's PowerPoint presentation will illustrate the strong Waterford connections with Newfoundland. He will be drawing from his own fieldwork researches in the 1970s while doing postgraduate studies at Memorial University of Newfoundland, and will play extracts from his three Radharc/RTE film documentaries of the 1980s and from his recordings in the 1970s in Newfoundland and Waterford. This promises to be one of the highlights of our upcoming lecture season.
Refreshments will be served after the event. So come, meet and chat with Aidan and his wife, Joyce who is an author and songwriter in her own right on the night.
Labels: Lectures
Join our mailing list and get all the latest news for free via email. Simply enter your email address in the box below and press the 'Join' button.
Waterford County Museum is a non profit voluntary museum. We would be grateful for any financial donation large or small.
Waterford County Museum 2014. All rights reserved. Please read our Terms of Use
Website By: Déise Design


text:
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# Setting Up Security for a Standalone Mode Server

Security in Pravega is off by default. You may start Pravega Standalone mode server with security enabled by modifying the security configuration before launching it.

Depending on how you configure security, either or both of the following occurs:

1. Client-server and internal communications are encrypted using SSL/TLS
2. Server authenticates and authorizes client requests

For standalone mode servers, you may enable SSL/TLS, and/ `auth` (short for Authentication and Authorization). We recommend that you enable both. The subsections below describe how to enable them.

## Enabling SSL/TLS and Auth

The configuration parameter `singlenode.security.tls.enable` determines whether SSL/TLS is enabled in a standalone mode server. Its default value is `false`, and therefore, SSL/TLS is disabled by default.

The configuration parameter `singlenode.security.tls.protocolVersion` configures the TLS Protocol Version. Its default value is `TLSv1.2,TLSv1.3` which is a mixed mode supporting both `TLSv1.2` and `TLSv1.3`. Pravega also supports strict `TLSv1.2` and strict `TLSv1.3` modes.

Similarly, the configuration parameter `singlenode.security.auth.enable` determines whether `auth` is enabled. It is disabled by default as well.

The following steps explain how to enable and configure SSL/TLS and/ `auth`:

1. Locate the `standalone-config.properties` file.

   If you are running standalone mode server from source, you can find it under the `/path/to/pravega/config` directory.

   If you are running it from the distribution instead, you can find it under the `/path/to/pravega-<version>/conf` directory.

2. If enabling SSL/TLS, optionally prepare the certificates and keys for SSL/TLS.

   In the same directory as the `standalone-config.properties` file, you'll find default/provided PKI material. You may use these material for SSL/TLS.

   If you'd like to create your own material instead, you may follow similar steps as [those](https://github.com/pravega/pravega/wiki/Creating-TLS-material-for-Pravega-security) used for creating the supplied material.

2. If enabling SSL/TLS, configure SSL/TLS parameters.

   If you are using custom material, replace the paths of the files accordingly.

   ```java
   singlenode.security.tls.enable=true
   singlenode.security.tls.protocolVersion=TLSv1.2,TLSv1.3
   singlenode.security.tls.privateKey.location=../config/server-key.key
   singlenode.security.tls.certificate.location=../config/server-cert.crt
   singlenode.security.tls.keyStore.location=../config/server.keystore.jks
   singlenode.security.tls.keyStore.pwd.location=../config/server.keystore.jks.passwd
   singlenode.security.tls.trustStore.location=../config/client.truststore.jks
   ```
   For descriptions of these properties, see [Pravega Security Configurations](./pravega-security-configurations.md).

3. If enabling `auth`, configure `auth` parameters.

   ```java
   singlenode.security.auth.enable=true
   singlenode.security.auth.credentials.username=admin
   singlenode.security.auth.credentials.pwd=1111_aaaa
   singlenode.security.auth.pwdAuthHandler.accountsDb.location=../config/passwd
   ```
   For descriptions of these properties, see [Pravega Security Configurations](./pravega-security-configurations.md).

   Note:
   * The default Password Auth Handler supports `Basic` authentication for client-server communications. You may deploy additional Auth Handler plugins by placing them in the classpath.

   * The default handler's configuration file shown above - `passwd` file - contains a single user with credentials containing username `admin` and password `1111_aaaa`.

   * To create additional users or change the password for the default `admin` user:

     a) Create a file containing 1 or more entries of the form  `<user>:<password>:<acl>;`.

        For example: `jdoe:strong-password:*,READ_UPDATE;`

     b) Use the PasswordCreatorTool to create a new file with the passwords encrypted. Configure this new file instead of the supplied `passwd` file.

4. If enabling SSL/TLS, ensure that the server's certificate is trusted.

   Note: This step is only needed the first time you run SSL/TLS-enabled standalone mode with a certificate. If you have already imported the certificate earlier, you don't need to do it again the next time you launch the server.

   A server certificate can be rendered trusted via either Chain of Trust or via Direct Trust.

   * **Chain of Trust:** A chain of trust, which is the standard SSL/TLS certificate
     trust model, is established by verifying that the certificate is issued and signed by a trusted CA. To establish chain of trust for a certificate signed by a custom CA, we need to import the certificate of the CA into the JVM's truststore. The provided `server-cert.crt` is signed using a CA represented by another provided certificate `ca-cert.crt`: so, when using those certificate, you should import `ca-cert.crt` file.

   * **Direct Trust:** This type of trust is established by adding the server's
      certificate to the truststore. It is a non-standard way of establishing trust, which is useful when using self-signed certificates.

   Here's how to import the provided CA certificate file `ca-cert.crt` to Java's system truststore, for establishing 'Chain of Trust':

   a) Change directory to Standalone mode config directory.

      ```bash
      $ cd /path/to/pravega/config
      ```
      or
      ```bash
      $ cd /path/to/pravega-<version>/conf
      ```

   b) Convert the X.509 PEM (ASCII) encoded `ca-cert.crt` file to DER (Binary) encoded format:

      ```bash
      $ openssl x509 -in server-cert.crt -inform pem -out ca-cert.der -outform der
      ```

   c) Import the certificate into the local JVM's trust store:

      ```bash
      $ sudo keytool -importcert -alias local-CA \
           -keystore /path/to/jre/lib/security/cacerts  -file ca-cert.der
      ```
      When prompted for keystore password, use the default JRE keystore password `changeit` or the custom one that you might have configured for the JRE.

   Note: If you want to use a custom truststore instead of adding the certificate to the system truststore, create a new truststore using Java keytool utility, add the certificate to it and configure the JVM to use it by setting the system properties `javax.net.ssl.trustStore` and `javax.net.ssl.trustStorePassword`.

Now that you have enabled and configured security, restart the standalone mode server and [verify](#verifying-security) that security is working.

## Verifying Security

1. Verify that the controller REST API is responding properly:

   ```bash
   # If both TLS and Auth are enabled
   $ curl -v -k -u admin:1111_aaaa https://<host-name-or-ip/localhost>:9091/v1/scopes

   # If only Auth is enabled
   $ curl -v -u admin:1111_aaaa http://<host-name-or-ip/localhost>:9091/v1/scopes
   ```

   Note: `-k` in the command above avoids hostname verification and is needed only if you are enabling SSL/TLS. If you are using the provided certificate, the host's DNS name/IP isn't the subject (in `CN` or `SAN`), and therefore hostname verification will fail. `-k` lets the command to return data successfully. You can find details about curl's options [here](https://curl.haxx.se/docs/manpage.html).

2. Optionally, run security-enabled Reader/Writer from [Pravega sample applications](https://github.com/pravega/pravega-samples/blob/master/pravega-client-examples/README.md) against the standalone server to verify it is responding appropriately to `Read/Write` requests.

   To do so, configure security in the client application and run it. The example below assumes both TLS and `auth` are enabled. If TLS is disabled, modify the Controller URI scheme to `tcp` instead of `tls` and remove the lines that add
   TLS-related client-side configuration.

   ```java
    ClientConfig clientConfig = ClientConfig.builder()
                 .controllerURI(URI.create("tls://localhost:9090"))

                  // TLS-related client-side configuration
                 .trustStore("/path/to/ca-cert.crt")
                 .validateHostName(false)

                  // Auth-related client-side configuration
                 .credentials(new DefaultCredentials(this.password, this.username))

                 .build();
   ```

  You can find a client example with security enabled [here](https://github.com/pravega/pravega-samples/tree/master/pravega-client-examples/src/main/java/io/pravega/example/secure).

  Note:
  * Remember that clients can access standalone mode servers through the localhost interface only. Therefore, the hostname in the Controller URI should be specified as `localhost` in client applications when accessing standalone mode servers.
  * `.validateHostName(false)` disables hostname verification for client-to-segment-store communications.


The Fellowcraft Club provided and served dinner this past Saturday to the Good Shepherd Tabernacle. The dinner served received many compliments. We were light with help when Bro T. Mott came in to help. Bro Mott recently had surgery and is recovering but came to help anyway. Then, Bro K. Rhodes walked in bringing the troops from the GOW School. These young men eagerly served the dinner and bused the tables. Many members from the Tabernacle were curious who these polite young men were. Bro Rhodes spent a couple of minutes talking to the guests about the GOW School and the men he brought. It was a fun and easy evening.
Appetizer: Cheese and cracker platter with mini sausages in a zesty sauce.
Main Entrée: Marinated chicken breast along with scalloped potatoes and peas.
Thanks to those who came and supported the lodge.
We sincerely thank the Good Shepherd Tabernacle for continuing to put their trust in us for their dinners. All money raised by the Blazing Star Lodge #694 F&AM is used to fund the Fellowcraft Club's charitable works and organizations. If interested in booking our banquet room for your group's next function please view our menu and contact us.