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Tim Story has proven himself as an adept storyteller, whose films combine compassion and humor infused with adrenaline. Possessing a unique insight into people and all of their real flaws and quirks, Story uses this, and a passion for telling stories and developing characters, to bring the wide range of human emotion on-screen.
FANTASTIC FOUR: RISE OF THE SILVER SURFER is a follow-up to Fantastic Four, in which he brought the beloved Marvel Comics series to life. Having been a fan of The Fantastic Four comics his whole life, Story jumped at the chance to helm the film adaptation.
Story is also executive producer of the television series Standoff.
Story's acclaimed feature studio debut, Barbershop, was released in September 2002 by MGM. Starring Ice Cube, Anthony Anderson, Cedric the Entertainer, Troy Garity and Eve, the film proved to be a box office hit, spawning a sequel, a spin-off film, and a television series to date.
Prior to Barbershop, Story completed two feature length films - The Firing Squad and One of Us Tripped - which he wrote, directed, produced, edited and even financed himself. One of Us Tripped was winner of the Black Filmmaker's Hall of Fame Film Festival.
Born and raised in Los Angeles, Tim Story was introduced to filmmaking at a very early age. At age 12, he inherited an 8mm camera from his older brother, and realized his passion lay behind the camera. He was often seen around his neighborhood making silent movies, recruiting family and friends to play the characters in his stories.
In high school, Story's love of storytelling gained an additional outlet as he began a career in music, rapping with Ice T's Rhyme Syndicate. Story's rap group, TDF, was in the process of signing a record deal with Warner Bros. Records, when a neighborhood rival fatally shot one of the members. After the tragedy, Story switched creative gears and began producing and directing talent shows and variety musicals. Story also had aspirations of enrolling in USC's prestigious film program and honing his skills as a filmmaker, which he made a reality.
After film school, Story worked at an independent record label, where he was able to combine his passion for film and music by directing his first music video. He has since gone on to direct dozens of music videos for such cutting edge acts as N'Sync, Tyrese, and Jon B, among others.
Story and his writing partner Brian Buccellato have completed several dramas that are currently being developed as future projects. He is currently developing Society Cap with Tom Hanks' Universal-based company, Playtone.
Read earlier biographies on this page.
Tim Story Facts
Birth Name Timothy Kevin Story
Occupation Director, Producer
Birthday March 13, 1970 (52)
Sign Pisces
Birthplace Los Angeles, California, USA
Height 5' 8" (1m73) How tall is Tim Story compared to you?
Ride Along 2
Fantastic Four: Rise of the Silver Surfer
Think Like A Man
Think Like A Man Too
Ride Along With Gag Reel
Continue » Find more details on the Tim Story Movies page
Bio courtesy Fox for "Fantastic Four: Rise of the Silver Surfer" (10-Jun-2007)


September 12, 2015 By heather 29 Comments This post may contain affiliate links. Read my disclosure policy.
Halloween Mason Jar Cakes with chocolate spider web toppers make a cute treat for your next Halloween party.
Here is my sad attempt at drawing spider webs. You can print some out or free hand it like me, you just need a basic guide when you are piping the chocolate.
Put the chocolate into a piping bag or even a Ziploc bag. Microwave in 30 second intervals until it melts.
Make sure to place wax paper over the drawing and pipe the chocolate directly onto the wax paper. Let it harden for 10 minutes and they will be perfect to add to your cakes. I ended up sprinkling a little edible glitter onto my webs before they dried to give them some sparkle.
Place paper baking cup in each of the regular size muffin cups.
Mix cake mix as directed on box, using water, oil, and eggs.
Place in muffin cups and bake per directions on box, approximately 18 minutes.
To make the frosting, crèam butter in a mixer and add marshmallow crème.
Mix in powdered sugar and vanilla and mix until blended about 4 minutes.
Divide frosting into 2 bowls. Add 3 drops of purple food coloring to one bowl and mix. Add 3 drops of green to the other bowl and mix.
Remove paper baking cups from cupcakes. Cut each cupcake in half horizontally.
In each jar, place 1 cake half in the bottom. Add purple frosting to a Ziploc bag or piping bag. Cut off the corner and squeeze frosting over cupcake. Sprinkle with candies or sprinkles.
Repeat layers and end with frosting and sprinkles.
For the webs. Draw or print out spider web on paper. Place a sheet of wax paper over the drawings.
Place candy melts in Ziploc bag or piping bag. Microwave in 30 second intervals until chocolate had melted. Cut off small tip of bag.
Trace the spider web with the chocolate on wax paper and let sit until hardened.
Such a fun treat to make with our kids this fall; thanks so much for sharing this wonderful mason jar treat!
i can see this for Halloween. I love the colors and the kids would love it.
These are so cute! I bet your kiddos love them!! I love the addition of the chocolate web!
Love your spider web stencils!! So creative. And seriously, the cakes in the jars look amazing!
I'm obesessed with Halloween too, will try your recipe, it looks perfect!
Neat idea and great project! This would be a fun one to do with the kids next month!
Thanks! Yes the kids loved the spider webs.
Your chocolate web is so cool! I have to make these for my little one this fall!
Thank you! They are really easy and a hit with the kids.
Spookilicious! We have Christmas stuff in the shops already – where has the year gone to?
These are so freakkin' adorable!! I love the layers of colors and the spiderweb tutorial. So creative and fun!
These are so cute and fun to make with kids, I also love, like really love the colors that you choose!
Thank you! Wanted something different than orange and white.
You certainly have the colours nailed for haloween on this one, nice job!
These are so cute! My granddaughter will love them. Thanks.
This is so much fun! I just love the colors you got going on in those jars !
SO adorable! My sisters will love this!
Thank you! They are so fun for kids.
This is so cool for Halloween!! Totally loving it and saving it !


Keynote Address: "Rights"---Right Or Wrong?
I've had cause to look back over the first forum of the Society which was held on 28 February 1986. The views that were put at that meeting caused such consternation in the Federal Parliament that some of us who had been involved thought it would be nationally irresponsible to hold a second meeting and so disrupt the country.
However, there have now been 12 such meetings of this forward thinking Society which, in those early days, was regarded not in those terms at all but as a damnable pursuer of the unreasonable.
The major theme at that conference was union power---in fact the abuse of union power at that time gave rise to the Society.
I thought it would be worthwhile looking back for a moment at just how unreasonable were the contributors at the first meeting of the Society in pursuing their thoughts and experiences and offering them for consumption.
There were a number of wise things said at the inaugural forum. I wish to quote but three.
The first is from a contribution by Wayne Gilbert who was General Manager of the South East Queensland Electricity Board and who had fought and won a dispute on behalf of the Government of Queensland in 1985.
He said that at the end of that dispute 'the Government empowered me to enter into individual personal contracts with the employees'.
'Essentially they are', he said 'common law contracts between us and the individual employee, legally enforceable, which provide for a prohibition of strike, and no union preference under any circumstances'.
A similar system is now in operation in New Zealand.
The second was from the late Gerry Gutman, in a quite fascinating offering upon the infamous and now discredited Hancock Report which outlined the future direction for industrial relations in Australia. He said 'a further reform measure would be to give encouragement to the creation of unions on a workplace or company basis'.
And the third was from a rather long and somewhat boring rendition by the then President of the National Farmers' Federation.
'Implicit in this proposal is the eventual re-establishment of the employment contract between employer and employee, enforceable at law, and able to be prosecuted by the existing inspectorate machinery'.
All this good sense constituted a hanging offence back in 1986. Seven years later it has become the very essence of the debate. In many cases it has become the very essence of the practice.
Why were we saying back then we should bring negotiations to the workplace?
It was of course about changing the attitudes of people. But how were we to go about encouraging those changes?
By making the work more rewarding. And how do you do that? By involving the employees, by inviting them to take responsibility for their actions and by engaging them in the negotiations over their pay and conditions, for example, so they become a vital part of the operation.
If we want this country to be better there must be involvement. How can we do that unless there is participation in the designing and in the doing?
Everyone may not fly to the top, but every single person will perform better if they feel part of the plot.
Those three offerings from 1986 were in some respects close to the general policies which the Government has appropriated from this organisation and the Coalition.
I was delighted, in a way, that the Prime Minister has been recently indulging in a degree of grand larceny.
As John Howard observed, perhaps we should be flattered.
Maybe you too should be flattered that he has finally absorbed so many of the ideas that were so presciently put at these gatherings.
We could be flattered until we realise of course that two seminal points of the Government's policy differ from your speakers' offerings.
We only have to look back as far as last year to see how this Government fortified a privileged position for the unions. The changes to the Industrial Relations Act legitimised only enterprise bargains in which unions were a party. This prevented employees in unionised workplaces reaching bargains with which their unions disagreed and excised from the system the majority of workers in non-unionised private sector enterprises.
There is no doubt that the workplace bargaining envisaged by the Prime Minister will be under some form of extended compulsion in trade union membership---not workplace union membership as was advocated so long ago at your inaugural seminar.
I believe great strides have been made in changing attitudes, but many workplaces remain stultified by the rules.
Unionism as we know continues to lose favour. The thrust has become one of recreating some compulsion by arrangement with the Government because trade unions have not been able to stand the test of the market place.
This compulsion was once achieved by coercion, that is, through compulsory membership of craft unions.
Natural attrition has driven much of this change---trade union membership in non government business is now, for example, under 30 per cent.
But union membership should not be reducing. It will I believe, go up once the structure is workplace-based and open unionism prevails.
The award system is also breaking down, and that is why the unions are moving away from their beloved central system.
There are thousands of examples in the country today where industrial "law" is out of kilter with economic reality, people have to choose and increasingly, they are choosing more flexible arrangements.
So the Government has come to the trade union's rescue.
So now you can have an enterprise arrangement if you're an employer but only if you negotiate with the trade union collective on the other side.
It is collective bargaining on the one hand and a single enterprise negotiation on the other and a bit one-sided I would have thought.
It won't work of course, at least not in the sense of increased productivity and performance. Some industry organisations have already said so and it would be even better if more of them did.
The position that trade unions achieved for themselves, diminishing but not gone, was a special right, a privilege whereby they were safe from attack by many of those that they had wounded.
They of course attained that special position by their strength which was achieved to some extent on merit, to some extent by compulsion and to some extent by the consistent failure of others to ensure everyone abided by all the rules of the industrial relations system.
In 1977 a number of new clauses were added to the Trade Practices Act, especially sections 45 D and E which outlawed secondary boycotts and made it more difficult for unions to damage other parties without bearing some penalty.
Now of course the Government will try again, as it has tried on two previous occasions, to remove those penalties and to re-create an immunity for unions. This must be resisted at all costs because it is undemocratic and unfair, and would give again a special privilege to one group and not others.
We are seeing yet another claim to such a special privilege in South Australia where two journalists have claimed that they should not be obligated by law to reveal the names of individuals who have provided information on which news stories have been based.
In one case, the journalist is already in prison arising from his unsuccessful claim to legal privilege, and the second awaits a verdict, having pleaded guilty to a charge of contempt of court rather than reveal the principal source of a series of articles which have allegedly cost the State Bank of South Australia $500,000 in lost business.
Both these journalists claimed that they had a right to protect their sources, a view not shared by the Courts. Justice Owen Dixon's eloquent view on this subject in 1940 was that there should be 'no obligation of honour, no duties of non disclosure arising from the nature of a pursuit or calling which could stand in the way of the imperative necessity of revealing the truth in the witness box'.
Although I am an occasional press correspondent, I don't believe that I should have any special place of privilege.
So those special privileges of compulsory unionism, the special "right" to escape from the rigours of sections 45 D and E, or the privilege of being able to refuse to reveal a source because journalists believe they are in a special vocation must be resisted.
All these claimed rights are quite wrong. But not all rights are wrong and I wish to talk about the right to stability and security proffered to all by the present constitutional arrangements.
I've given a great deal of thought over the last six or nine months to the matter of our Constitutional ties to the British Monarchy. Not because I think that it was something that needed changing, but because the issue had been raised and now has a head of steam. So the matter is to be addressed.
Why do some wish to change to a Republic?
For those who do, there are presumably a number of reasons. Is it because they think it will establish further our national identity and independence and self reliance?
Or is it to give ourselves confidence to face the future or to make those of us who've come from other countries in recent times feel more secure? Or to further fit in with Asia and to make them feel more comfortable?
Or is it because they believe the 'system' or the Monarchy is an anachronism and has broken down?
Have they discovered some cultural or Constitutional shortfall?
I am not convinced by any of these arguments because I believe there is a risk that the unchallenged stability and security of the past will be threatened.
I discern on this issue much greater consternation among supporters of a Constitutional Monarchy than I do from those supporting change. Much more emotion too.
Our Constitutional Monarchy is not damaged. It's not an institution that has even been brought into disrepute.
Not in any way at any time. Even in 1975, the vitriol was against particular people but not those Constitutional arrangements.
Now there is a move to change them.
I am for changing the industrial relations system because it is a damaged system which isn't working properly. I am not for forcing change, but for encouraging change.
When contemplating a change to the Constitution under which we have lived for 93 years and as we approach the celebration of its centenary, we should proceed with very great caution indeed.
I ask you, where is the groundswell of opinion that has given rise to the promotion of these changes?
How shall we ensure that the stability and external security of the past can be maintained if we were to make those changes, whatever they may be?
How can we be sure that our almost invisible threads to the United Kingdom, if broken, would not mean less external security?
How can we be sure that in spelling out the reserve powers, hitherto unpublished, we won't dispel some of the mystery which has allowed them to work so well.
When the Crown does not own the land, who will own it?
One thing is sure---that if the republic comes, the flag will go, just as sure as night follows day.
All these things are currently settled. The question is, what good reason, what overwhelmingly good reason, do we have to risk the change?
I don't accept therefore that change to a Republic is inevitable.
But I do accept that if I were promoting that change I would say that it is inevitable.
Those good men and women who are convinced about the republican cause of course have the right to put up their ideas for change.
If these changes were to take place, they could only take place after a long democratic process.
And a single yes/no referendum will not suffice.
There should be a number of questions, probably over a period of time where a series of propositions are put to the people.
The explanations of the alternatives must be made crystal clear and both sides of the argument must be put forward.
It seems to me that, as some have already said, to disrupt, in the seven years left until the celebration of 100 years of federation, or the lead up to it, with any form of acrimonious debate on this issue would be a scar upon our country's history.
It would be a complete denial of the wonderful forethought, good sense and commonsense of those who put together that Constitution 90 odd years ago.
That cannot be allowed to happen.
Perhaps even more vexing is a most extraordinary decision of the High Court of Australia made in June last year. This decision has created a new form of land title in Australia. A new right called "native title" was thereby created over some Australian land.
"the common law of this country recognises a form of native title which, in cases where it has not been extinguished, reflects the entitlement of the indigenous inhabitants, in accordance with their laws or customs, to their traditional lands ..."
I was extremely surprised when I read that decision because a great deal of land had already been transferred in various ways to aboriginal tribal groups around Australia by the Federal Government and by various State governments.
And I was even more surprised because I knew that Aboriginals already had a right to enter, travel across, and live on much of the pastoral land of Australia, even though it had been alienated to other people in the form of pastoral leasehold land.
And I also knew they had been granted that right for the very purpose of allowing them to follow their traditional pursuits.
Apart from some mild impediments, those Aborigines have the same sorts of rights as they had before 1788. In other words, to do the things they had always been doing.
And those sorts of rights are absolutely unarguable and as they should be.
And therefore, like many people, I was astonished when a hitherto uncontemplated title suddenly popped out of the ground, so to speak.
Last year various people were of the view that the decision was not something that we should worry about. Now, many of them are extremely worried, including those who last year did not think their pastoral leases were at risk.
Of course the High Court failed to define very clearly what native title really is or how it differs from the rights I have described above.
And there is now a case proceeding in the Supreme Court in Western Australia for native title in the Kimberleys---the Barunga claim, a Mabo-style claim. That claim is against the current operating leaseholders of pastoral leases, amongst others.
"by the valid exercise of their respective powers, provided any exercise of those powers is not inconsistent with the laws of the Commonwealth".
There is a fear that the States face the prospect that in extinguishing this new title, compensation may have to be paid because not to do so might contravene the Racial Discrimination Act. But only to those Aborigines who have not already had their title intentionally extinguished by the States before 1975.
The decision of 3 June 1992 has put a great deal of turmoil into the matter of who owns a great part of the land mass of Australia. It is simply not true to say that this title is a limited title---the definition is far too loose for anyone to claim so.
The High Court only specified the broad features of native title. I fail to see how a treaty could be negotiated on behalf of all aborigines in regard to those matters that could possibly be binding upon a potential claimant because it's the circumstance or continuing attachment to the land which would determine the success or otherwise of the claim. So how a few people could negotiate for everybody I fail to contemplate.
The Court has put at risk not only the unalienated Crown land including great and vast tracts of Western Australia which may be very valuable from the point of view of minerals at some time in the future. It has put at risk many of the lakes of this country which are not alienated in the technical sense. It has put title in doubt as to the Forest Commission lands of the various States, and other lands, including National Parks, that for various purposes have not been designated or alienated to other people.
And thus the national development of all of that land comes into doubt because the tenure of it is now in doubt. It will be interesting to see how the directors of some of these mining companies will sign off their accounts when they are trying to evaluate the current value of their assets.
We have a new form of title, hitherto uncontemplated by anybody who had previously designed the various land ownership systems of Australia.
Brennan J. who wrote the leading judgement on this matter in describing the parcel by parcel dispossession of Aboriginal land, upon which he based his judgement, said "their dispossession underwrote the development of the nation".
Now it is an extremely difficult matter as to how to remedy this dreadful dilemma---a dilemma which will militate against our development about which not only our mining companies and pastoral lessees are very worried, but even Japanese companies are now publicly starting to express reservations and that's something that they have strongly resisted in the past.
And to top it all off we now have some pastoral leaseholders in my State of South Australia saying to the Minister, the new title that you're offering me, the new 42 year-old title that you're offering me at the expiration of my current lease may not be as good as the old one I've got which only has 10 or so years to run.
That of course is based on the fact that it may well be that the issuing of that new title could be adjudged to be racially discriminatory under the Racial Discrimination Act as the title was issued after 1975 when that Act came into being.
But two things are patently obvious. This adventure indulged in by the High Court less than one year ago has left large tracts of Australia in a turmoil as to title and therefore in those areas, risks the stability and future development of the nation.
It is urgent that existing title be secured by some form of State and Federal legislation, or action by the High Court itself. In deciding to overturn past practice, the High Court did not take notice of its own cautionary comment on the costs and benefits of change---whether "the disturbance to be apprehended would be disproportionate to the benefit flowing from the overturning".
Well I think the High Court has got that calculation wrong.
In deciding to grant a new right it failed to take account of the immense damage it would do to the rights other Australians thought they had.
So now we have a number of positions for the aboriginal people. There are those who may have a claim to native title. There are those who have land rights. There are those who have rights granted by pastoral lease and there are those who've had their rights extinguished altogether because they happened in days gone by to live in Sydney, Melbourne or the middle of Canberra.
I would have thought there's nothing more discriminating than that.
The national development of this country depends upon a quick and fair solution to this matter. The cost of failure will be horrendous, not only in financial terms for current and future potential investors, but in terms of dashed hopes for some aborigines and many other Australians.
On occasions then, the creation of "new rights" creates many wrongs and sometimes tends to hurt in the end the very people they are designed to help. That applies to all but one of the subjects I raise with you tonight and it is the very reason for raising them.
The right of stability and security we have had bestowed upon us by our Constitutional arrangements for the last 100 years however, only proves that much forethought and good commonsense leaves nothing but benefit for those who follow.


At the character selection screen in duel mode, have player one choose a character first. Then, choose the custom skill setting. Then, take the memory card in slot one and move it to memory card slot two. Player two can now choose a custom skill setting without having two memory cards. If you do not like the random choice of three characters that Shenron powers-up, restart the GameCube. All your Dragon Balls will still be there when the game is resumed. Summon Shenron again until you like the choice of the three random characters.
This has no purpose other than a laugh, and will not unlock anything in the game. Enter practice mode (or two-player duel if you want to play with a friend) and choose your characters and stage. When the fight starts, put as much distance between you and your opponent as possible. If in practice mode, set the opponent's action to Deflect-Back at the pause menu. Once you are as far away as desired, launch an energy ball by pressing Circle. In practice mode, your opponent should knock it back at you. Just before the ball hits you, press Guard and if it timed correctly, it should be reflected back at the opponent. In a two player match, you can play it like a proper game. For example, flip a coin to see who serves (launches the energy blast). Set a score limit. If the Ki ball is knocked away, hits, or is hit by another Ki blast, whoever reflected the ball last gets the point.
Within the game you can collect the seven Dragon Balls. In order to get them, you have to buy them at Mr. Popo's shop. However, they are very rare. They cost 8000 Zenie each and will only appear in a "Recommended" or "Gambled" Capsule. After collecting all seven, go to the Caps List option in the "Edit Skills" menu. Then go along to the second to last list. If all seven Dragon Balls are present, press A and you will be asked if you wish to summon Shenron. Select "Yes" and you will be given the option to "Breakthrough" three random characters. Breakthrough is a Capsule which will open all the Death Moves, Transformations, and Physical Moves of the character in possession. However, it takes up seven ability slots and cannot be equipped in conjunction with anything else. After choosing your character, the Dragon Balls will disappear and you will have to collect them all again. If you do not like the random choice of three characters that Shenron powers-up, restart the GameCube. All your Dragon Balls will still be there when the game is resumed. Summon Shenron again until you like the choice of the three random characters.
When in Tournaments, instead of trying to kill the CPU opponents, just lure them close to the edge of the ring. Tap A + Down to move behind the opponent, then use a strong move to knock them out the ring.


Any Recommendations for Tablets for Field Use by Maintenance Technicians?
Does anyone have any experience or recommendations on which tablet works best, or not at all, for MD. Also, what tablet features would you say are most useful or you wish you had?


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"I believe personal values carry into the business world. For me, that means honesty and integrity. Always keeping your word — in front of the courts, and with clients — is an essential part of being a good lawyer."
Richard has been living in Vernon since 2006. He is a father of three girls, and is active in the community with the Kalamalka Rotary Club. Currently, he practices in the areas of personal injury litigation and commercial litigation. He has completed numerous trials in both the Provincial Court and Supreme Court of British Columbia.
Bachelor of Arts English and History
Master's Degree Japanese Studies
University of Essex, UK
RBarton@davidsonlawyers.ca Phone: 250-542-1177
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After practicing law in the Fraser Valley and Kelowna, Richard joined the firm as an associate lawyer in 2006 and became a partner in 2010. Currently, he practices in the areas of personal injury litigation and commercial litigation. He has appeared at all levels of court in British Columbia, including the Court of Appeal, and has completed numerous trials in both the Provincial Court and Supreme Court of British Columbia.
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Smartphone Apps Development…
Smartphone Apps Development at a Glance
Smartphones have come to be very popular with human beings throughout the globe. Many software program builders worldwide make the first-rate amount of cash via developing software programs and applications for these cell devices. There are pretty a few systems that can be used for cellphone apps development. Each platform has its very own language and apps improvement tools with which we will create packages. The two maximum important systems are IOS and Android. Let's take a brief have a look at each of them.
Information for the developers
The Samsung Galaxy S3
The AT&T Nokia Lumia 900
The reliable language for Apple's cell devices is IOS, which is based totally on Objective-C. With this language, we can create programs for iPhone, iPad, and iPod Touch. There are distinct versions of IOS. However, all of them are programmed the usage of Objective-C and Xcode, that's the development surroundings (IDE) powered by Apple. With it, we can create desktop applications for Mac and iOS. Xcode plays a crucial function in iPhone apps improvement, and most options to create iPhone programs (Appcelerator, PhoneGap, and Corona) usually rely on this device for growing the very last build.
The only trouble is that Xcode is most effective to be had with Mac. So, to create iOS applications, you need a computer that uses Mac OS. Important requirement: to install applications inside the App Store and test applications developed for your very own iPhone / iPad, you ought to buy a developer license that charges around $a hundred per yr.
Developing apps with the help of Android is relatively less complicated. First, we have Java's language to expand packages and a SDK platform that runs on all the popular working systems, including Windows, Linux, and Mac. If you want an improvement environment, you can use a plug-in called Eclipse ADT, which consists of a simulator that fits all structures and is unfastened and open source. Also, so that you can increase applications for Android-primarily based cellular devices, human beings do not need to buy any licenses, and they can do it for free.
If you are a software program developer who desires to create your first smartphone application, you will need to pick the excellently suitable platform for you. For example, if you have higher expertise in Objective-C and have the right of entry to a Mac pc, you could choose iOS. However, if you feel you have a better hold close to JAVA as a language, you can choose phone apps development with Android.
Ainol Novo7 Aurora II Cortex is a tablet computer from the stables of Ainol Electronics Company Limited. The distinctiveness approximately this machine is that it has the brand new Dual-Core Cortex-A9 Amlogic8726-M6 1.5GHz processor. The reason the employer has decided to use a twin middle processor is due to its benefits. Since each of the cores may be nearby at the same die in a dual center processor, the cache coherency circuitry might be able to perform at a higher clock charge. The performance of the processing unit is improved due to the combined effect of the cores. Since indicators will be traveling shorter distances, their degradation can be lots much less. So, it's far feasible to send greater records with a twin-core processor. Further, the electricity used in a dual-middle processor could be less also. Simply put, customers can get better performance with less power.
As a long way, because the Graphical Processing Unit of Ainol Novo 7 Aurora II Cortex is worried, it has a MALI 400 processor. The running gadget used in this pill is Google Android four.Zero.Three and the approach for working this is a 5 factors capacitance touch display screen. Android four.0.Three platforms can help in the diffusion of optimizations, and they can assist in fixing bugs additionally on pill computer systems. Perhaps, this is the motive the company has opted for this Android 4. Zero.3 platform.
The RAM used in this tablet is DDR3 1G 1333MHZ, and the Flash Memory is 16GB Nand flash. The machine has a beautiful 7 inch TFT LCD Multi-contact HD IPS Capacitive display with a decision of 1024 x six hundred Pixels. Only the front digicam of 2.0 Mega Pixels is available in this pill. There is an integrated 3700 mAh Lithium battery in this. According to the corporation, the battery standby could be there for about 14 hours.
This pill can help numerous languages, from Arabic to Russian, Chinese, Ukranian, Vietnamese, etc. The well-known consensus of reviewers is that this pill is the quickest of many of the present devices. In truth, whilst the business enterprise started releasing Ainol Novo merchandise, no person imagined that these capsules would capture the market to this volume because the initial response became only modest. But, many humans in the US and different nations have begun switching to this device. Of route, the popularity of this tablet is only demand-driven.
The price of the Ainol Novo 7 Aurora II Cortex tablet is quite reasonable, and that is really a delivered advantage for all purchasers who earn numerous stages of earnings. The corporation appears to have achieved notable research approximately the expectancies of consumers earlier than releasing the Ainol Novo tablet computers. This has made the sector suddenly sit up straight and take observe of this merchandise. The robustness of those gadgets is an assessment of the opposite products from different contemporary organizations.
Trying to examine smartphones is getting more difficult as more groups now not the best were supplying merchandise in 2012, but the products are getting better and better. A lot of this stems from Android and the Ice Cream Sandwich becoming to be had to developers and manufacturers; as an OS, its miles beginning to a degree the playing area and permit makers to attend to functions and capability. Here are the top smartphones to shop for in 2012; they represent smartphone satisfaction but are in no way all this is to come back this year.
One of the first-class smartphones of 2012 in line with every reviewer and tester that gets their hands on it's for the Samsung Galaxy S3. It runs on Ice Cream Sandwich and has saved a robust consciousness on realistic use. It incorporates such capabilities because the "Smart Stay" uses the front 720p digicam to detect if you are reading the screen and stops the screen from powering down.
It has a prolonged battery existence manager to provoke heavy customers, and its layout is sleek, narrow, and contemporary. Samsung did several workers at the realistic factors of the cellphone in growing its RAM length and switching to a processor that may absolutely manage 4G. Because it runs on Android, there are hundreds of apps to be had to be used. This is the best moderate downfall of the S3; the middle navigation tries to imitate an app and might get difficult at times.
One of the opposite top smartphones of 2012 is the Nokia Lumia 900. This isn't a favorite of maximum reviewers who are Android and iOS blind. However, this is truly the fine of the home windows smartphones. It has cameras, an 8-megapixel rear camera, and a 1-megapixel front dealing with one.
This is surely one of the first-class business smartphones because it can access all the standard cellular Windows apps that are nevertheless awkward to convert from below the Android structure. The 900 makes use of a four.3 inch AMOLED ClearBlack display runs on a 1. A four GHz processor, and as soon as the Windows 7.8 Phone update is released, the fave telephone of much greater.


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fxr agonists
Pharmacophore-based discovery of FXR agonists
43 TGF-beta derived from the seminal vesicle binds to epithelial
43 TGF-beta derived from the seminal vesicle binds to epithelial cells within the uterus, altering their local secretion of cytokines. Fetal loss and abnormalities are considerably greater when embryos are transferred to recipients after pseudopregnancy is achieved when female mice are mated with seminal-vesicle-deficient males without exposure to male seminal fluids,
Selleckchem BKM120 compared with intact males. Preliminary evidence suggests a role for seminal fluid-derived factors in promoting embryo implantation in humans, although the clinical results are inconsistent. Gutsche et al.45 studied the influence of seminal plasma on the mRNA expression of cytokines in human endometrial epithelial and stromal cells in culture, demonstrating a concentration-dependent stimulation of IL-1 beta, Il-6, and LIF mRNA expression. Kimura et al.46 analyzed endometrial NK cells for their expression of CD16 and CD56 by flow cytometry, providing
preliminary evidence that seminal plasma exposure recruited CD56 (bright) NK cells into the endometrium. Clinical studies performed at the time of laboratory-assisted reproduction have been inconsistent. Billinge et al. found that embryo implantation rates were higher in women exposed Navitoclax mw to raw semen at the time of follicular aspiration, during in vitro fertilization and embryo transfer, than in its absence.47 This phenomenon was observed in a subpopulation of women with occluded fallopian tubes, eliminating the possibility of in vivo fertilization of oocytes that may not have been retrieved at follicular aspiration. Subsequently, inconsistent results were obtained following deposition of seminal fluid intravaginally during IVF-ET. Fishel and associates failed to observe
a difference in pregnancy rates when semen was deposited intravaginally, immediately after the time of oocyte recovery.48 Tremellen et al. observed no difference in pregnancy rates following transfer of frozen embryos, in a group of women who had coitus at the time of embryo transfer versus a aminophylline sexually abstinent group, but the proportion of viable pregnancies at 6 weeks' gestation was higher in the former group (odds ratio 1.48, P = 0.036).49 In another study, when cryopreserved seminal plasma was placed intravaginally just after follicular aspiration, the clinical pregnancy rate was 37.3% in the SP group versus 25.7% in the saline control group, but this difference did not reach statistical significance.50 Embryo implantation rates were not different in a third study in couple who had coitus at least once 12 hr after embryo transfer.51 A study in which seminal fluid was placed intravaginally at the time of intrauterine insemination (IUI) with spermatozoa washed out of semen revealed no difference in pregnancy rate when compared with a saline control.52 Unfortunately, all of these studies were of small size and did not define their clinical populations well.
Interestingly, a recent study has proposed that GVHD developing i
Interestingly, a recent study has proposed that GVHD developing in immunodeficient mice implanted with thymic tissues and human HSC is a result of mature thymocyte populations residing within the thymic tissues that are not tolerant to the murine host and expand following emigration to the periphery [26]. In this study, the development of GVHD in NSG recipient mice was minimized
with depletion of thymocyte populations by using thymic tissues that were initially cryopreserved and then thawed prior to implant and by the treatment of mice with a monoclonal antibody to human CD2. However, implanted NSG mice were followed only for 20 weeks post-implant for the development of disease, and it
remains to be determined whether this treatment approach will reduce the late-onset find more GVHD that our results show develops after 20 weeks. The onset of xeno-GVHD in NSG–BLT mice may be a direct result of a breakdown in tolerance mechanisms [72]. It is possible that the levels of mouse cells within the human thymic organoid are not sufficient to enable the negative selection of human T cells that are reactive with mouse MHC (H2). This would result in the development see more of mature human T cells that recognize mouse MHC as a xeno-antigen and ultimately mediate a GVHD. Our data show that co-implantation of mouse fetal liver with the human thymic tissues was insufficient to prevent or delay the onset of GVHD in NSG–BLT mice. Interestingly Hassall's corpuscles were readily detectable within the BLT thymic organoid. Hassall's corpuscles are typical of human thymic tissue, and the presence of these structures in the medulla suggests that the BLT thymus
is developing a normal architecture [73]. Moreover, Hassall's corpuscles have been proposed to be critical for supporting Bay 11-7085 the development of thymic dendritic cells, which induce the differentiation of human Treg [61]. CD4+/CD25+/FoxP3+/CD127low human Treg are detectable in the periphery of BLT mice [31], and our data show that development of GVHD in NSG–BLT mice was not associated with a decline in peripheral human Treg numbers. We are currently comparing the functionality of human Treg from younger and older NSG–BLT mice to determine if the onset of GVHD can be correlated with a loss in Treg function. An additional parameter that may influence the development of GVHD in NSG mice implanted with fetal thymic and liver tissues may be the use of antibiotics in the drinking water, which may change the microbiota of the mice and alter immune regulation [74].
1B) This demonstrated that the enhanced fitness of F5 T cells tr
1B). This demonstrated that the enhanced fitness of F5 T cells transferred to Rag1−/− hosts was indeed IL-7 dependent. We wished to examine the molecular mechanisms that were responsible for the range of cellular fitness observed in F5 T cells receiving different strengths of IL-7 signalling in vivo. First, we asked whether IL-7R– F5 T cells PKC412 had an increased susceptibility to apoptosis. We examined caspase activity in IL-7R– F5 T cells at the earliest stages of in vitro culture by assessing fluorescently-labelled caspase inhibitor peptide (FLICA) binding to active caspases. While little caspase activity was apparent
in control F5 T cells, caspase activation was readily detectable in a significant population of IL-7R− F5 T cells during the 1 h in vitro duration of the assay (Fig. 2A). We also assessed onset of apoptosis by measuring annexin V binding to phosphatidylserine, whose translocation from inner selleck products to outer membrane leaf is an early event during cell death. While few viable IL-7R+ or IL-7R– F5 T cells were annexin V+ ex vivo, 1 h culture of IL-7R– F5 T cells was sufficient to induce a substantial population of high forward scatter (FSChi) Annexin V+ cells not evident in control
IL-7R+ F5 T cells (Fig. 2B). Finally, we also assessed specific activation of caspase 3, one of the executioner caspases, in IL-7R– F5 T cells directly ex vivo and following culture in vitro. Ex vivo, neither IL-7R+ F5 control nor IL-7R– F5 T cells had elevated levels of activated caspase 3, suggesting that there were not high levels of detectable apoptosis in vivo. However, following culture
for 24 h, activated caspase 3 was readily detectable in both cell types but was particularly elevated in IL-7R– F5 T cells in which viability was also more reduced (Fig. 2C). Taken together, these data indicate that the reduced fitness of IL-7R– F5 T cells Docetaxel mouse is associated with a very substantial elevation in their susceptibility to induction of apoptosis. It has long been recognized that T cells cultured in vitro with IL-7 up-regulate Bcl2 and this is thought to be a key mechanism through which cell survival is promoted. We therefore investigated whether modulation of Bcl2 expression in vivo by IL-7 signalling could account for the differential survival of IL-7R– F5 T cells and IL-7R+ F5 T cells from lymphopenic hosts. Examination of F5 T cells transferred to Rag1−/− hosts revealed a robust increase in Bcl2 expression levels (Fig. 3A and C), consistent with the continued survival of these cells in vitro in the absence of exogenous growth factors (Fig. 1B). The increase in Bcl2 levels observed was similar to that previously reported in F5 T cells cultured in vitro with exogenous IL-7 2. Surprisingly, in IL-7R− F5 T cells that were incapable of receiving IL-7 signalling 2, Bcl2 levels were identical to those in control IL-7R+ F5 T cells (Fig. 3B and C).
These results demonstrate for the first time distinct conformatio
These results demonstrate for the first time distinct conformational determinants characteristic of activating versus tolerogenic MHC–peptide complexes involved in human autoimmunity. A common basis for several autoimmune diseases, including multiple sclerosis (MS), type 1 diabetes (T1D) and rheumatoid arthritis (RA), is the strong linkage between human leukocyte antigen (HLA) genotype and susceptibility to the disease 1–3. While some alleles
are tightly linked to certain diseases, others confer protection and are found extremely rarely in patients. This linkage is not surprising due to the involvement of T cells in the progression of these diseases. Activation or dysregulation of CD4+ T cells directed to self MDV3100 chemical structure organ-specific proteins, combined with yet-undefined events, may contribute to the pathogenesis of a variety of human autoimmune diseases. MS is an immune-mediated demyelinating and neurodegenerative disease of the central nervous system (CNS) 4. Susceptibility to MS is associated
with HLA class II alleles, mostly the DR2 haplotype that includes the DRB1*1501, DRB5*0101 and DQB1*0602 genes 5. DRB1*1501 is a well-studied risk factor of MS that occurs in about 60% of Caucasian MS patients versus 25% of healthy controls. Contribution of these risk factors to disease process likely involves presentation of self-antigens by disease-associated MHC expressed on antigen-presenting cells (APC) that activate T-cell-mediated CNS inflammation. Suspected MS autoantigens include myelin proteins such as myelin basic protein (MBP), proteolipid Abiraterone research buy protein (PLP), and myelin oligodendrocyte glycoprotein (MOG). T cells from MS patients were found to predominantly recognize MOG 6, 7, as well as other myelin proteins, and the MOG-35-55 peptide was found to be highly encephalitogenic in rodents and monkeys 8, 9 and to induce severe chronic EAE in HLA-DRB1*1501-Tg mice 10. T1D involves progressive destruction of pancreatic β-cells by autoreactive T cells specific for antigens expressed in the pancreatic islets, including glutamic acid
decarboxylase (GAD)65 11. GAD65 is a suspected islet autoantigen in T1D, stimulating both humoral and cellular self-reactivity in at-risk and diseased subjects. Demeclocycline Abs to GAD65 in combination with Abs directed at two additional islet autoantigens are predictive markers of T1D in at-risk subjects 12, and the GAD-555-567 peptide has the identical sequence in all GAD isoforms in human and mouse. This highly immunogenic determinant was found to be a naturally processed T-cell epitope both in disease-associated-HLA-DR4(*0401)-Tg-mice 13 and human T1D subjects 14, 15. Antigen-specific activation or regulation of CD4 T cells is a multistep process where co-ligation of the T-cell receptor (TCR) with complexes of MHC class II (MHC-II)–peptide on the surface of APC plays a central role.
These data demonstrate that geohelminth-associated Treg influence
These data demonstrate that geohelminth-associated Treg influence immune responses to bystander Ag of mycobacteria and plasmodia. Geohelminth-induced immune modulation may have important consequences for co-endemic infections and vaccine trials. Rural parts of Indonesia, particularly on islands further away from the more developed areas of Java, are characterized by
a traditional lifestyle and by high burdens of parasitic infections such as geohelminths and malaria. One of the hallmarks of chronic helminth infections is induction of T-cell hyporesponsiveness 1. While the mechanisms involved may be multiple, several studies have pointed toward the possible involvement of natural and inducible check details Treg in downregulating effector T-cell responses upon chronic infection 2. A limited number of studies have been performed on Treg dynamics in human www.selleckchem.com/products/AG-014699.html helminth infection. Schistosoma mansoni-infected
subjects in Kenya had higher CD4+CD25hi T-cell levels compared to uninfected individuals and the numbers decreased after treatment 3. In lymphatic filariasis, patients show decreased Th1 and Th2 cell frequencies, which might in part be explained by the upregulation of expression of Treg associated FOXP3, TGF-β and CTLA-4 in response to live Brugia malayi parasites 4. Interestingly, it has also been shown that helminth infections can affect responses to unrelated Ag, such as those expressed in vaccines or by other pathogens 5. Geohelminth infections have, for example, been associated with reduced immune responses to BCG vaccination 6 and to the cholera vaccine 7. With respect to co-infections, epidemiological studies in areas where helminths and Plasmodium spp. are co-endemic, have so far not clarified whether there is a detrimental or beneficial interaction (reviewed in 5,
8). At the immunological level, a recent study has shown higher IL-10 responses to malaria Ag in children infected with Schistosoma haematobium and/or geohelminths such as Ascaris lumbricoides, Trichuris trichiura and hookworm 9. These results would support the recently proposed hypothesis that helminth infections might facilitate the establishment of malaria infection through compromising immune responses, while simultaneously may prevent severe malaria-related pathology through counteracting strong inflammation 10. While numerous studies in Methane monooxygenase experimental models have provided evidence for increased FOXP3+ Treg function during different helminth infections, only a few studies have addressed the functional capacity of these human Treg. To investigate Treg activity in geohelminth infections, we have analyzed Treg frequencies and immune responses to BCG and Plasmodium falciparum-parasitized RBC (pRBC) in infected and geohelminth-uninfected subjects from a rural area of Flores island, Indonesia. Proliferative responses to BCG and pRBC were lower in helminth-infected compared to uninfected children.
at 10 and 20 μM concentrations
at 10 and 20 μM concentrations C646 in vitro produced a 13% and 39% reduction, respectively (data not shown). The effects of doxycycline on MMP-9 levels were further analyzed by Western blotting using monoclonal antibody (mAb) against MMP-9 under a reducing condition (Fig. 5). The band density was scanned with a laser densitometer to quantify the effect of doxycycline on MMP-9 levels released into the CM. Ten and 20 μM doxycycline reduced MMP-9 protein produced by lipopolysaccharide-treated macrophages by 14% and 46%, respectively. The reduced level of MMP-9 (92 kDa) protein shown by Western blot was consistent with the functional activity of 92-kDa gelatinase shown by gelatin zymography. Using a nonreduced conditioned medium, the high-molecular-weight protein
shown in the gelatin zymograms reacted with mAb against MMP-9, and after reduction with 5% 2-mercaptoethanol, this immunoreactive band disappeared (data not shown). This high-molecular-weight protein could be a dimer of 92-kDa gelatinase (gelatinase B). Interstitial collagenase activity was measured by SDS-PAGE/fluorography using [3H]-collagen as a substrate (Fig. 6). The collagenase activity was measured after activation of the proMMP by 1 mM APMA (Golub et al., 1995). As shown in Fig. 6, the macrophage-conditioned media exhibited classic collagenase activity because the neutral proteinase degraded the α1 (1) and α2 (1) components of the type I collagen into 3/4 (αA) and 1/4 (αB) degradation fragments. Degradation of [3H] collagen was inhibited Cyclopamine by 10 and 20 μM doxycycline. The SDS-PAGE/fluorography was
scanned with a laser densitometer to quantify the effect of doxycycline on collagenase activity released into the CM. When lipopolysaccharides were cultured with macrophage, doxycycline at 10 and 20 μM concentrations appeared to reduce the interstitial collagenase activity in a dose–response IMP dehydrogenase manner. When macrophages were incubated with lipopolysaccharide on [3H]-fucose-labeled ECM, 20% of the matrix-associated fucose radioactivity was solubilized. Doxycycline at 20 and 50 μM concentration reduced ECM from degradation by 47.6% and 61.9%, respectively (Fig. 7). During the inflammatory response, after the initial polymorphonuclear leukocyte emigration into the lesion begins to wane, mononuclear phagocytes are attracted from the vasculature by chemotactic signals and migrate into the tissues. These infiltrating activated monocytes/macrophages then release proteinases and cytokines, which can directly or indirectly cause tissue damage. When doxycycline was added to the monocyte-derived macrophages in cell cultures at 10 and 20 μM concentrations, it reduced both interstitial collagenase and 92-kDa gelatinase B activities. This reduction could be a result of reduced gene expression, reduced secretion and/or increased proenzyme degradation.
Co-immunoprecipitaton demonstrated nuclear phosphorylated-smad2 a
Co-immunoprecipitaton demonstrated nuclear phosphorylated-smad2 and phosphorylated-Y645-β-catenin complex (pSmad2/pY654-β-catenin) formation after TGF-β1 treatment. Inhibition of pSmad2/pY654-β-catenin by Smad7 or F-TrCP-Ecad GSK-3 inhibitor reduced TGF-β1-induced increase of ILK, demonstrating a role of pSmad2/pY654-β-catenin in upregulation of ILK, a known inducer of fibrosis. Conclusions: These data demonstrated that TGF-β1-induced autophagy promoted profibrotic processes in C1.1 cells through pSmad2/pY654-β-catenin-mediated
upregulation of ILK. Inhibition of autophagy may limit fibrosis. 164 INTERACTIONS BETWEEN GLUCAGON-LIKE PEPTIDE-1 (GLP-1) AND THE RECEPTOR FOR AGES (RAGE) IN DIABETIC NEPHROPATHY K SOURRIS1,2, S PENFOLD1, J WANG1, M COOPER1,2, M COUGHLAN1,2 1Baker IDI Heart and Diabetes Institute, Melbourne;
2Monash University, Central and Clinical School, Melbourne, Australia Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. While current clinical therapies improve the quality of life of diabetic patients with DN, they only slow the rate of progression and therefore novel therapies are required. The study of the Glucagon-like peptide (GLP)-1 pathway is of recent clinical interest as demonstrated by the number of clinical trials targeting GLP-1. The role of the GLP-1 axis in DN is not clearly understood. Therefore, the aim of this study was to elucidate the interactions between RAGE and the GLP-1 axis in DN. Methods: Primary mesangial cells (MC) were isolated AZD8055 ic50 from C57BL/6 mice and treated with AGE-modified BSA (AGE-BSA)
(100 μg/mL) or BSA control (24 h). Cells were concurrently treated with or without with the GLP-1 agonist, Exendin-4 (1 nM). Cell surface expression of RAGE and GLP-1 receptor (GLP-1R) was analysed by flow cytometry. 8-week old C57BL/6 and RAGE (−/−) mice were rendered diabetic by low-dose Cytidine deaminase streptozotocin. In addition, C57Bl/6 control and diabetic mice were further randomised to receive Exendin-4 (2.5 μg/kg). All mice were followed for 24 weeks. Results: Exposure of MC to AGE-BSA resulted in an increase in cell surface expression of RAGE and a decrease in GLP-1R (P < 0.05). By contrast, treatment of MC with Exendin-4 prevented the AGE-mediated increase in RAGE expression and concomitantly increased GLP-1R (P < 0.05) levels. A decrease in circulating and renal GLP-1 was exhibited in diabetic wild type mice compared to control which was not seen in diabetic RAGE(−/−) mice (P < 0.05). Exendin-4 reduced albuminuria and renal levels of RAGE compared to diabetic C57Bl/6 mice (P < 0.05). Conclusions: These data demonstrate an interaction between RAGE and GLP-1 in DN and further investigation is warranted.
The maximum change in fluorescence over baseline was quantified u
The maximum change in fluorescence over baseline was quantified using softmax pro (version 5) software (Molecular Devices). The chemotaxis assay was performed using a 48-well chemotaxis micro-chamber (Neuroprobe, Cabin John, MD). Mast cells (50 μl of 3 × 106 cells/ml) were added to the upper wells separated from the lower wells containing chemoattractants by a polycarbonate membrane with pores 8 μm in diameter. After 3 hr of incubation, the mast cells that migrated and adhered to the underside of the filter were fixed and stained with DiffQuick. The membrane was mounted,
and the cells that migrated were counted under a light microscope in three randomly chosen high-power fields. In some experiments, inhibitors were added
2 hr before the assay, and chemotaxis was evaluated as described above. Mast cells (1 × 106 Ridaforolimus research buy cells) were suspended in BD Cytofix/Cytoperm solution (BD Biosciences Pharmingen, San Diego, CA) for 20 min according to the manufacturer's instructions. Following one wash with BD Perm/Wash buffer, an antibody against the α7 nAChR (Santa Cruz Biotechnology, Santa Cruz, CA) this website or an isotype control rat IgG1κ antibody (BD Biosciences) was added for 30 min. The expression of the α7 nAChR was evaluated by FACS after staining with FITC-conjugated goat anti-rat IgG (BD Biosciences). Mast cells (100 μl at a density of 3 × 107 cells/ml) were transfected with 400 nmα7 nAChR siRNA or control siRNA (Applied Sulfite dehydrogenase Biosystems) using the Amaxa Cell Line Nucleofector Kit V, programme T-030 (Lonza Bio, Cologne, Germany), according to the manufacturer's instructions. Gene silencing was carried out for at least 24 hr, and the efficacy of knockdown was confirmed by quantitative real-time PCR using α7 nAChR-specific primers/probes. Following transfection, the cells were stimulated with catestatin peptides, and an assessment of degranulation or cytokine/chemokine production was carried out as described above. Statistical analysis was performed using one-way analysis of variance with a multiple
comparison test or Student's t-test (Prism 4; GraphPad Software, San Diego, CA), and P < 0·05 was considered to be significant. The results are shown as the mean ± SD. The β-hexosaminidase enzyme is released in combination with histamine and, therefore, is a marker of mast cell degranulation.20 As shown in Fig. 1(a), wild-type catestatin and its variants markedly induced β-hexosaminidase release from LAD2 cells at 2·5 μm, whereas nanomolar concentrations (100 and 500 nm) did not cause mast cell degranulation. Wild-type catestatin, Gly364Ser and Pro370Leu displayed nearly identical potencies, whereas Arg374Gln showed lower activity. Scrambled catestatin used as a control peptide had no effect on mast cell degranulation, suggesting that catestatin-mediated human mast cell activation is specific.
mexicana LPG relates with its success to infect murine macrophage
mexicana LPG relates with its success to infect murine macrophages. Leishmania parasites are the causal agents of Leishmaniasis, which is transmitted to mammals, including human beings, by phlebotomine sand flies. learn more Depending upon host immune response and parasite species, leishmaniasis is characterized by a wide spectrum of clinical manifestations. In Mexico, Leishmania mexicana is the causative agent of two forms of cutaneous leishmaniasis: localized cutaneous leishmaniasis (LCL), characterized
by ulcerative skin lesions that develop at the site of the bite of the sand fly, and diffuse cutaneous leishmaniasis (DCL), which consists of multiple nonulcerative nodules that spread throughout the skin, leading to severe mutilation High Content Screening because of the invasion of naso- and oropharyngeal mucosae. In murine models infected with L. mexicana, it has been shown that BALB/c mice are significantly more susceptible and develop larger dermal lesions as compared with C57BL/6 mice (1–3). In murine and human macrophages, it has been established that
the respiratory burst of the cell with generation of reactive oxygen intermediates (ROI), such as H2O2 and O2−, is largely responsible for parasite control, as these molecules have been reported to be fatal for Leishmania promastigotes (4–8). Another toxic molecule for the parasite is nitric oxide (NO), which is generated by macrophages stimulated by cytokines, such as TNF-α and IFN-γ (9,10). Respiratory burst activity and NO production are regulated by phosphorylation events mediated by protein kinase C (PKC), a family of serine/threonine kinases comprising at least 13 different members (11). The mammalian PKC superfamily is subdivided into three subfamilies on the basis of their structural differences and related cofactor requirements: cPKC (classical PKC) isoforms (α, βI, βII Alectinib molecular weight and γ), which respond both to Ca2+ and diacylglycerol (DAG); novel PKC (nPKC) isoforms (δ, ε, θ and η), which are insensitive to Ca2+, but dependent on DAG and atypical PKCs (aPKCs, ι/λ, ζ), which are nonresponsive to the co-factors, but may be activated by other lipids and
by protein–protein interactions. Macrophages and monocytic cells express the Ca2+-dependent and DAG-dependent isoenzymes α, βI, and βII, the Ca2+-independent isoenzymes δ and ε and the atypical isoenzyme ζ (12,13). Among the isoenzymes that are related to macrophage defence functions are PKCα, which has been shown to be the predominant isoenzyme required for the O2− production (14), whereas PKCβ is related to cell chemotaxis (15,16). It has been shown that PKCβ can be regulated by C-C chemokines (17). It has been reported that Leishmania donovani parasites, as well as Leishmania lipophosphoglycan (LPG), which is the most abundant glycoconjugate on the parasite surface, can impair signal transduction mediated by PKC in macrophages, thereby increasing intracellular survival of the parasites (18–21).
This fragment was PCR amplified from S epidermidis 1457 genomic
This fragment was PCR amplified from S. epidermidis 1457 genomic DNA using the primers Pica1 and Pica2 (Table 2), introducing EcoRI and BamHI cleavage sites, respectively. The amplified PCR products (0.5 kb) were cloned into the shuttle plasmid pYJ90 (Ji et al., 1999), yielding pQG53. The S. epidermidis spx gene with its ribosome-binding sequence was PCR amplified using the primers spx-u and spx-d, introducing BamHI and HindIII cleavage sites, respectively. The amplified PCR products (0.4 kb) were cloned into pQG53 (placed downstream of the icaADBC promoter),
yielding pQG54. A 3′ terminal mutant allele of the S. epidermidis spx gene was constructed by mutagenic PCR using the primers spx-u and spx-d2m, introducing BamHI and HindIII cleavage sites, respectively. The amplified PCR products (0.4 kb) were cloned into pQG53 (placed downstream of the icaADBC promoter), yielding pQG55 for overexpression. To inhibit the expression of Spx, the Sunitinib concentration coding sequence of spx
was amplified with HindIII and BamHI using the primers spxa1–spxa2, and then ligated to PQG53, yielding the antisense plasmid PQG56. Sorafenib concentration Semi-quantitative biofilm assays and primary attachment assays were performed as described in our previous work (Wang et al., 2007), except that B-medium, in place of TSB medium, was used. The diamide sensitivity test was performed as described previously (Larsson et al., 2007) and modified as follows: S. epidermidis strains were grown in B-medium to the stationary phase and diluted in a fresh B-medium to an OD600 nm value of 0.1. Fifty microliters of the diluted culture was plated on a B-medium plate. Three disks, each with 5 μL of Interleukin-3 receptor 500 mM diamide, were placed on the plate. The plate was incubated at 37 °C for 18 h, and the diameters of inhibition halos were measured. Quantitative RT-PCR was performed as described previously
(Vetter & Schlievert, 2007) and modified as follows: Staphylococcus epidermidis strains were grown in B-medium. At an OD600 nm of 0.5, cells in 2-mL cultures were harvested and resuspended in 1 mL Trizol (Invitrogen). The cell suspensions were transferred into Conical Screw Cap Microtubes (2.0 mL; Porex Bio Products Group), where 1/3 of the volume was glass beads (0.1 mm; Biospec Products). Cells were disrupted by shaking with a Mini-Beadbeater (Biospec Products) at maximum speed for 30 s. Tubes were then incubated on ice for 5 min. This shaking/cooling cycle was repeated four times. Then, the suspension was centrifuged. Total RNA isolation from the supernatant was performed according to the instructions on Trizol (Invitrogen). Total RNA was treated using the TUBRO DNA-free™ kit (Ambion) to remove contaminating DNA. Approximately 1 μg of total RNA was reverse transcribed with a ReverTra Ace-α kit (Toyobo) using random primers. Of the 20-μL reverse-transcription reaction, 0.2 μL was used as a template for real-time PCR using SYBR-green PCR reagents (Toyobo), and the reactions were performed in an iCycler machine (BioRad).
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Mirage News World	July 22, 2019 9:38 am AEST Date Time
CMO we must work together to make our world safer and healthier
In her final annual report as England's Chief Medical Officer and UK Chief Medical Adviser, Professor Dame Sally Davies outlines the UK's leading role in global health and highlights the need to share international knowledge and experience.
The report makes clear that by focusing purely on domestic health, we risk failing to control the shifting tide of global threats. Diseases and their determinants do not respect international borders. Ebola, antimicrobial resistance and widening health inequalities are already presenting significant challenges.
Accompanied by a collection of letters from key world health leaders to the Chief Medical Officer, Professor Davies' report makes a series of recommendations to secure a prospering health system and population both at home and across the world.
The Chief Medical Officer calls for recognition that the world is changing, with health threats becoming increasingly similar internationally. By engaging with other countries we can make the NHS more adaptable and sustainable.
Pandemics, genomics and vaccinations, Professor Davies states, are just some of the areas in which we can learn from the successes and mistakes of other nations.
Chief Medical Officer Professor Dame Sally Davies said:
Investing in global health is the smart thing to do because it is in our mutual interest – it creates a better world for us and for future generations. It helps to keep our population safe.
We should invest in systems and solutions that contribute to making health more equitable, secure and sustainable. What we learn abroad will improve our NHS and support our domestic efforts to make sure no one in the UK is left behind.
Tags:Border, disease, future, future generation, Government, Professor, sustainable, UK, UK Government, vaccination, world
The Honourable Bardish Chagger, Minister of Diversity and Inclusion and Youth, wraps up a five-day…


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F.U.S.E
CHRIST CULTURE
CHRIST CULTURE KIDS
BEYOND SUNDAYS
CORPORATE PRAYER
MEET OUR LEADERSHIP
Rev. Bryan Attinson Sr., Apostle
Bryan is an excellent communicator who preaches and teaches biblical truths in a way that reaches a wide spectrum of society.
His greatest passion is to equip leaders, from every segment of life, to lead with a spirit of excellence and dedication. His warm spirit and gracious style have awarded him the opportunity to share the reconciliation message nationally and internationally. He has conducted leadership training conferences in several nations, including Russia, India, Kenya, Zambia, and Venezuela.
Bryan is passionate about expanding God's Kingdom through church planting and raising up strong leaders in every segment of society. He and his wife, Antoinette, are the proud parents of two adult children, Dionna and Bryan Jr.
Rev. Dr. Antoinette Attinson, Lead Pastor
Antoinette has ministered to God's people for over 25 years with great passion and conviction. Earning multiple degrees, including a Doctorate of Ministry from Palmer Theological Seminary of Eastern University, she preaches the Word of God bringing clarity to biblical concepts for today's living. Through her accurate prophetic word healing, wholeness, and freedom have been experienced by many people, nationally and internationally.
A published author, international speaker, and founder of Eagle's Touch Ministries, Antoinette possesses a shepherd's heart with a deep desire to see God's people develop spiritually and impact the world. She is not only Lead Pastor of Christ Church in Howell, New Jersey but also trains and equips leaders of all levels to be a voice within the church and in the Kingdom. Her radio and television programs are broadcasted internationally on the worldwide web. She and her husband, Bryan Attinson, are the proud parents of two adult children, Dionna and Bryan Jr.
Rev. Byron McDaniel
Byron uses over 20 years of servant leadership experience to oversee the Leadership Development and Multimedia Ministry at Christ Church.
His passion for leadership has allowed him the opportunity to share his knowledge with potential leaders in both profit and non-profit organizations. He has traveled extensively throughout the United States and Canada with the purpose of making disciples. Byron is dedicated to developing tomorrow's leaders today. He and his wife, Jacqueline, have been married for over 20 years and are the proud parents of one adult child, Brandon McDaniel.
Rev. Jaqueline McDaniel
Jacqueline gives oversight to the teaching arm of Christ Church and Christ Culture, our Young Adults Ministry.
She uses her exceptional communication gift to teach and encourage believers to serve the Lord with mind, body, and soul. Jacqueline is often called upon to speak at women's conferences, retreats, and universities. She holds a BA in Literature from Rutgers University and an MA in English Literature from Seton Hall University. She and her husband, Byron, are the proud parents of one adult child, Brandon McDaniel.
Rev. John F. Madden
John is an Evangelist whose heart is to make clear the salvation message to a lost and dying world. He has preached on five continents and taught at leadership conferences in Russia and India. Along with his wife, Joanne, he has had the opportunity to travel to many parts of the world, sharing God's love to His people.
John oversees The Giving Project, the Outreach and Missions arm of the church. He also ministers weekly at the Monmouth County Correctional Facility. The Maddens and the Outreach team minister regularly in partnership with the Food Bank of Monmouth & Ocean Counties to distribute food monthly to those in need throughout the area. John and Joanne are the proud parents of four adult sons and seven beautiful grandchildren.
Rev. Joanne Madden
Joanne has a tender heart for those in physical and spiritual need. Her calling to the Missions field has led her to Israel, Egypt, Jordan, and China, where she has ministered openly, sharing God's love to His people.
Joanne serves alongside her husband, John Madden, in The Giving Project, the Outreach and Missions arm of the church. The Maddens and the Outreach team minister regularly in partnership with the Food Bank of Monmouth & Ocean Counties to distribute food monthly to those in need through the area. She and her husband are the proud parents of four adult sons and seven beautiful grandchildren.
Rev. Damon Pearson
Damon Pearson is simply a man who loves Jesus. He currently serves an an Associate Pastor and co-chairperson of Watchmen in Prayer (W.I.P.) prayer ministry at Christ Church.
In addition to his functions at church, Damon resides as the Senior Chaplain at Monmouth County Correctional Institution, where he shepherds hundreds of inmates, several dozen civilian staff members, four other chaplains and dozens of religious volunteers. Through his prison ministry he has witnessed hundreds of souls come to Christ over a nine year period.
A preacher of the gospel, Damon has expanded his reach internationally, ministering in London, England and Ghana, West Africa. However, his greatest accomplishment is that he has been married to his beautiful wife, Tomasina, for over 20 years and has two sons, ages 11 and 5. Damon's greatest desire is to love God, serve His people and impact the world for Christ through prayer.
OFFICE HOURS & CONTACT
MONDAY-FRIDAY, 9:00AM TO 3:00PM
(CHURCH OFFICE CLOSED ALL MAJOR HOLIDAYS)
71 OAK GLEN ROAD | HOWELL, NJ 07731
(732) 938.7500 PHONE
(732) 938.7001 FAX
INFO@CHRISTCHURCHNJ.COM
Copyright © 2020 Christ Church Howell. All rights and content reserved. Produced by The Biz Doctor


Ukrainian Regime Agents Attempted To Infiltrate Leadership Of Lugansk People's Republic 5 out of 5 based on 6 ratings. 6 user reviews.
Agents of the Ukrainian regime has attempted to infiltrate the leadership of the Lugansk People's Republic (LPR), Leonid Pasechnik, an acting head of the republic, said in an interview to Russia 24 television channel.
According to Pasechnik, the Ukrainian government is "working" to destabilize the situation in the LPR. He added that the agents attempted to hinder the administrative and economic development of the republic.
Pasechnik emphasized that LPR security forces implemented measures to neutralize the agents of foreign states.
The LPR has repeatedly reported about attempts of the Ukrainain regime to impact the situation in the republic and Ukrainian sabotage and reconnaissance groups to infiltrate the LPR-held area.
In November, the LPR announced that its security forces captured a sabotage and reconnaissance group that had been preparing terrorist attacks in the republic.
That's US democracy. Who the f… think someone will give you something free ???? What USA want to help you to be "democratic" for free ? Of course, it's not free.
The LPR needs to be extremely vigilant as these Nazi saboteurs will have intelligence and other assistance from the US, which helped and used many other Nazi (Dulles's rat lines) criminals from WW2 escape judgment. When it comes to Nazis, it appears the US has strong leanings, undoubtedly why it keeps supporting Ukraine's Nazis; having in common that they both want to destroy anything Russian and have desired same since WW2.
Mi6 has SAS agents dressed in civilian clothing speaking with American accents training Ukrainians inside of Ukraine today and have been for several years.
This information came from an SAS officer themselves who wanted this information made public.
I have repeated shared this factual information.


I feel that watercolors make the portrait feel more alive than with oil based colors or acrylic.
Using watercolors gives the custom portrait paintings a more etheric feeling. I feel that this medium makes the custom watercolor portraits feel more alive than with oil based colors or acrylic. The blending of the watercolors makes it easier to show the morphing of the person with the plants.
Back in art school I once had professor who told me that the idéa of watercolor was to create a blend of colors with excessive use of water.
Think of Georgia O'Keeffe's watercolor studies with big blocks of color or the etheric scenes of water and fire meeting in the evening horzion.
Although I agreed with her that watercolors were idéal for that kind of landscaping I always felt that I could do so much more with watercolors.
Watercolor is alive and will shape the custom portrait paintings in a way were you can see how paper, color and the artists thoughts all blend together.
Personally I feel that watercolors are more alive than for example oil based colors or acrylic. When I paint with watercolor I can see how the color is absorbed by the paper. There is really no way of going back once you have started adding or painting a line. You have to commit to the painting and if something is not turning out how you wanted you have to adapt in the moment.
While the paint is still fresh you have still some chance of making corrections to the custom watercolor portraits but you can not undo or go back on your choices, like you can with oil, acrylic or pencils. This makes the painting process perhaps more demanding but I feel it also let's me develop my concentration and attention to detail.
I also feel that by using watercolor as the medium for my custom portrait paintings the portrait itself get more connected to the elements.
This is me with one of my favourite Rhododendron plants.
If the weather is good I like to paint outdoors.
The idéa is to stylize the portrait so that it has a distinct "kawaii" aestheic but is still recognizable from the picture.
Big eyes, rounded face and a smile are some of the characteristics for Kawaii illustrations and Japanse Kawaii culture has been an inspiration for both my Amigurumis over at The Sun and the Turtle and here at Warm Squirrel.
What is the significance of the plants?
When someone chooses a plant of their preference or one that is meaningful for them I try to make a morphing of the person with the plant. My thought is that the plant becomes like a protection for the person.
There has been cases were a person has not known what plants to choose. In those cases I ask the person what their date of birth is and their complete name. Based on that information I try to search if there is a plant connected to the name of the person or see what kind of plants are connected to the persons Zodiac sign.
How can I order custom watercolor portraits?
The easiest way is to click on the "Order your custom portrait" link in the sidebar or below this post if you're on a mobile.
You will then be asked for an image of you or the person that you want me to paint and to give a description or note telling me what plants, flowers or pet you would like me to include in the custom portrait.
You can checkout with a Credit/Debit card or if you prefer with Paypal. Please contact me if you have questions or have something else in mind.


You may have heard of using ear candles to clear wax out of the ears. You may even rely on cotton swabs for the task. But have you ever tried Karna Purana, the Ayurvedic method of ear oiling? It is no surprise that Ayurveda recommends using oil to maintain the health of the ears; after all, Ayurveda, India's traditional healing system, is a huge proponent of using oil in and on all parts of the body. Oil is so highly revered in the Ayurvedic tradition that the Sanskrit term snehana means both "to oil the body" and "to love the body." Even 5,000 years ago, people in ancient India understood a concept which is making a comeback today: self-care translates to self-love. When you oil yourself through Ayurvedic practices such as Karna Purana, you are also loving the body through self-care.
Traditionally, sesame oil is used in Karna Purana, due to its warming, nourishing, anti-microbial and moisturizing effects. At PAAVANI, we like to take a modern approach to this ancient practice by infusing the sesame oil in our Karna Purana Ear Oil with organic lavender, which contains antibacterial, antifungal, analgesic, calming and soothing properties.
Ayurveda recommends using an ear oil as part of your daily dinacharya, or morning self-care routine. It can also be beneficial to integrate Ayurvedic ear oil into your nighttime ritual, as well.
DAILY USE: Gently massage 1-2 drops of warm Karna Purana Ear Oil into each ear canal.
WEEKLY USE: Lie down & rest on your side. Place 5-8 drops of warm Karna Purana Ear Oil into the exposed ear. Relax and let the oil absorb for 5 minutes. Release excess oil from the ear with a cotton ball. Repeat on the opposite side.
To warm the oil, submerge the glass bottle in hot water for 5 minutes. Make sure the oil is not too hot prior to administering.
When used regularly, our Karna Purana Ear Oil is a simple yet effective way to balance and maintain optimal ear health. We hope that learning about the many benefits of Karna Purana will help inspire you to begin incorporating ear oil into your own self-care routine!
nurture radiant health & beauty from within.
Begin Your Ayurvedic Journey Today!


Venetian Blinds Woori Yallock. Call us @ 1800 151 767 and get an exclusive range of Venetian blinds in Woori Yallock and Venetian blind installation services.
Blinds add a unique appeal to your home's décor and setting. Gone were the days when window covering blinds were used to be all bland and dull. The latest trends have brought new eye soothing blind designs and types which suits best with your home's overall look and fits well. Victorian Blinds is a renowned name in Woori Yallock, over the decades we have developed our presence in the market as best blind installation service providers. Not just this, our expertise makes our work reliable hence allowing the installation to sustain for years.
What are Venetian Blinds Woori Yallock?


text:
"Преображение Христостово" () е картина на италианския художник Джовани Белини от 1478 – 1479 г. Картината (116х154 см) е изложена в Зала 8 на Национален музей "Каподимонте" в Неапол. Използваната техника е маслени бои върху дърво.

История
Картината може би идва от параклиса "Фиокардо" в катедралата на Виченца. Еврейският надпис върху свитъка в ръката на Мойсей датира от 1478 – 1479 г., което дава представа за годините, в които е рисувана. Художникът е подписал произведението си с "IOANNES BELLI/NUS ME PINXIT".

Описание
Платното изобразява епизод, отразен в Евангелието, в който Христос на планината Тавор разкрива божествената си природа пред тримата си ученика Петър, Яков Зеведеев и Йоан Богослов, които са представени като поразени от преображението му. Наред с Христос са се материализирали и пророците Илия и Моисей, които държат в ръце свитъци, написани на еврейски.

В дъното на картината се виждат Мавзолеят на Теодорих Велики и камбанарията на базиликата Сант Аполинаре ин Класе в Равена, докато вдясно, на фона, зад голямото дърво има две човешки фигури, едната от които изобразява мюсюлманин с бял тюрбан на главата. Те разговарят и не виждат божественото събитие, което се случва.

Забележима в необикновения фон е естествената красота на природата, което е новост в изобразителното изкуство, открита във Венеция през онези години. Приложен е новият синтез между перспектива и геометрия – стил, наложен от Пиеро дела Франческа. На небето, в съответствие със светлината на Христос, облаците са раздвижени от вятър, от който идва божественият глас, който го провъзгласява за Бог Син.

Действието се извършва сред красив пейзаж с хълмове и планини, които се изгубват далеч на хоризонта и многобройни следи от спокойно човешко присъствие, като градът отдясно, замъкът и пастирът с пасящи крави отляво. Сливането между фигурите и ландшафта, благодарение на умелото прилагане на цветовете и светлината, които скриват контурната линия, придава на картината съвършен вид. Топлата и интензивна светлина придава на всеки детайл лъчиста красота, заимствана от чудодейното събитие.

Източници
 Mariolina Olivari, Giovanni Bellini, in AA.VV., Pittori del Rinascimento, Scala, Firenze 2007. ISBN 88-8117-099-X

Картини в Национален музей "Каподимонте"

redpajama_set_name: RedPajamaWikipedia


text:
<?php

namespace SxQueueDoctrine\Factory;

use SxQueueDoctrine\Controller\DoctrineWorkerController;
use Zend\ServiceManager\FactoryInterface;
use Zend\ServiceManager\ServiceLocatorInterface;
use SxQueueDoctrine\Controller\SxQueueDoctrine\Controller;

/**
 * WorkerFactory
 */
class DoctrineWorkerControllerFactory implements FactoryInterface
{
    /**
     * {@inheritDoc}
     */
    public function createService(ServiceLocatorInterface $serviceLocator)
    {
        return new DoctrineWorkerController();
    }
}

redpajama_set_name: RedPajamaGithub


text:
Q: Control visibility of layout Block on the basis of session value I want to display a layout block only when there is some attribute is set in customer session.
It can be controlled with a config value. Is it possible to do it with session too?

A: You can do but you'll have issues with Caches. Better to utilize something live Magento 2 private content in your case.
Refference:

*

*https://devdocs.magento.com/guides/v2.2/extension-dev-guide/cache/page-caching/private-content.html
Examples:

*

*https://belvg.com/blog/customer-data-management-in-magento-2.html

*https://amasty.com/blog/how-to-use-sections-in-magento-2/

redpajama_set_name: RedPajamaStackExchange


text:
UK Pays Tribute to Great Teachers
By Gail Hairston, Amy Jones, and Kody Kiser
The University of Kentucky Alumni Association presented its 2013 Great Teacher Awards to six recipients last night at a recognition dinner, followed by an appearance at Rupp Arena's center court during halftime of the South Carolina vs. UK basketball game.
The recipients are:
• Karen Badger, associate professor, College of Social Work
• Roberta Dwyer, professor, College of Agriculture
• Samuel Franklin, assistant professor, College of Medicine
• John Grove, professor, College of Agriculture
• Armando Prats, professor, College of Arts and Sciences
• Gerald Smith, associate professor, College of Arts and Sciences
Started in 1961, the Great Teacher Award is the oldest continuous award to recognize teaching at UK. The nominations are made by students. Selection of the award recipients is made by the UK Alumni Association Great Teacher Awards Committee, in cooperation with student organizations Omicron Delta Kappa and Mortar Board. Great Teacher Award recipients each receive a citation, an engraved plaque, and a $2,000 cash award.
Karen Badger is an associate professor in the College of Social Work, focusing on social work in health care, occupational stress and secondary trauma. She is also an active administrator within the college, taking on the duties of the director of undergraduate studies and associate dean for academic and student affairs.
"What I really enjoy about teaching is being able to help students connect what they are learning in the classroom with what they would be doing in the profession," said the social worker. "And I really like the energy of the students, their ideas; I like the interaction. I like being able to find creative ways to present material to have them engaged, and I like the, 'ah ha' moments. Some of those are small, some of those are big turning points. The most rewarding thing about teaching for me is being able to help students realize their potential," Badger said.
Roberta Dwyer is a professor of veterinary science in the College of Agriculture. She has been involved with biosecurity and equine infectious diseases for more than 20 years. Integrated with biosecurity, she is involved in the development of disaster plans for veterinarians and animal owners.
Dwyer says the most rewarding part of being a teacher is "helping students get through the really rough patches in life. I just got an email last fall from a student who got into veterinary school, and she said, 'Thank you for not giving up on me because you're the only teacher that told me I could do it.' That still just sends little shivers down my spine," she said.
Samuel Franklin is an assistant professor of anatomy and neurobiology in the College of Medicine, focusing on medical education research. He received his doctorate at Wake Forest University School of Medicine and conducted postdoctoral training at the same institution. He is interested in the development of integrative teaching methods in anatomical education.
"I enjoy making connections," Franklin said, "and I enjoy making or allowing, helping others make connections between things that they may or may not think are related, and when they make the connections, they begin to understand things better. I like watching people come to understand concepts, I like learning from others."
John Grove is a professor in the Department of Plant and Soil Sciences in the College of Agriculture. His specialty is the soil chemical and physical management across spatial scales. When he was surprised in his classroom by the award, he said, "It gives you a sense of accomplishment."
"You teach because you want (students) to develop, at least in part, some of the passion that you have," Grove said. "Teaching the next generation is critically important to what the university is and, of course, what it does. Research is important because it provides that new knowledge that I take to the classroom, so it enlivens the classroom. Nonetheless, the fundamental reason that you're here is to impart knowledge to that next generation that is going to take your place and the place of others."
Armando Prats is a professor of English in the College of Arts and Sciences with specialties in film, the Western, Western history and mythology, and the image of native Americans in popular films.
"There is something indescribably fulfilling about teaching. We leave them, a great deal of the time, transformed. We leave them enlightened to transform lives, to make other people's lives inherently better. What that spark does," Prats said, "it's not that it tells you that you are such a great teacher, that you enlightened this person, but that you and that student now have a common humanity. I would think that is what teaching should be about."
Gerald Smith is an associate professor of History with research interests in African-American history, education and the civil rights movement. He is a co-editor of the "Kentucky African American Encyclopedia" a book-length study of the history of African Americans in Kentucky.
"I teach because it gives me the opportunity to integrate my research and my teaching in a classroom over the course of several years," said Smith. "As my research changes and as students who come in over the course of the years change, it gives me the opportunity to share that body of knowledge with them and to impart the wisdom and the experiences that I've had over the course of the years from one generation to the next. The most rewarding part is clearly watching students develop over time, but the challenge is to bring a certain level of enthusiasm and appreciation for history that is contagious. With that, the students connect with that vibe and before they realize it, they're hooked as well."
great teacher award
armando prats
college of art and sciences
karen badger
roberta dwyer
samuel franklin
john grove


Many things, even small habits that you engage in without thinking, can drain your energy, which has a negative effect on your ADHD brain. Here's how to identify (and vanquish!) these "energy vampires" — and get more done.
Each morning I am aware that there is a finite amount of time and energy in this day," says Oprah Winfrey. Oprah knows the importance of time and energy management. I bet she also knows about energy vampires, the things lurking in our routines and habits that eat away our energy.
Energy is precious, especially to people like you and me, who work hard to manage our ADHD, aspiring to get ahead, be more, and have more.
What if you had more energy every day? What would you do with it? Start on that project you've been putting off? Finish the thing that you just haven't had the energy to finish? Focus a little extra time on getting organized, so that you're ready to attack tomorrow with all cylinders firing?
You begin each day with a full "bank account" of energy, and you spend it throughout the day. You have to manage how you use it. This is tricky, because we spend a lot of our energy unknowingly. Did you know that when you take a break to watch 15 minutes of YouTube hilarity, you lose 15 minutes of energy? A 10-minute water-cooler chat with coworkers debits your energy account. Your 30-minute commute listening to scream radio (which we used to call talk radio) takes an energy toll. Obsessing about something that didn't go your way makes a withdrawal.
These are minor offenders, but over the course of a day, they add up: At 3 p.m., you hit the wall, so there's no way you're going to tackle that long-postponed project. By 7 p.m., your energy account is overdrawn. You skip the gym and head for the sofa instead.
Here's the good news: When you focus more attention on your energy, you keep more energy in your account, and even get some compound interest.
> Sugar and carbs. If you're consuming sugar or simple carbs (having cereal or a donut or a bagel for breakfast) to jump-start your brain, you're using fuel that gives you a brief hit of energy, but flames out in minutes, leaving you hungry for another hit. Ditto for sugary "energy" drinks. These are also energy vampires.
Protein is where the sustained energy is. You want 30 grams of protein in your tank when you head out the door each day. This will extend your energy "delivery curve" significantly, and help you stay focused until close to lunchtime. You can make small energy deposits throughout the day by eating some raw nuts.
> Multitasking. When you multitask, you waste energy going between activities, because you have to re-engage each time you switch.
Pick a single to-do. Set a timer for 20 or 30 or 60 minutes. Start on one thing, single-tasking. When you focus your energy on one task, you move it forward faster and use less energy.
> Visual clutter. Sherrie Bourg Carter, Psy.D., says, "Clutter makes our senses work overtime on stimuli that aren't necessary or important." Clutter makes it difficult to relax, physically and mentally. That pile of papers you're saving or not dealing with is stealing energy from you.
Here's a way to slay the clutter vampire: Try to create a field of vision in your workspace in which there are no piles of paper or clusters of sticky notes. You don't have to organize them or trash them, just get them out of your line of sight to create the impression of a super-organized workspace. I "re-stage" my work area every time I sit down to tackle a major to-do. It is simple and powerful.
> A long to-do list. Ever heard of the Zeigarnik Effect? This psychological phenomenon explains why the multitude of undone to-dos on your long list taxes your mental energy by reminding you of everything that you haven't done.
I learned this tip from my coaching mentor, Laurie Dupar, PMHNP, RN, and founder of Coaching for ADHD in Seattle. Create a "wish list" of things you've moved off your to-do list. These are the items you admit that you're not likely or don't need to do on a timetable. By slimming down your to-do list, you'll have less energy escape your brain when you look at it.
Start paying some attention to identifying and defeating the energy vampires in your life. When you do, you will have a lot more energy with which to meet your goals.