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Infographic, Data Visualization, Maps, Charts, Guides
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Last Contents
List of Current National Football League Stadiums [Infographic]
yucel
Build, Cheat Sheet, City, Construction, Culture, Guide, Industry, Life, news, Quick Reference, social, Sport, Travel
Source http://www. graphs .net/201304/list-of-current-national-football-league-stadiums-infographic.html
Tags: Aloha Stadium, Arrowhead Stadium, Bank of America Stadium, Candlestick Park, CenturyLink Field, Cowboys Stadium, Edward Jones Dome, Everbank Field, Fawcett Stadium, Fedex Field, FirstEnergy Stadium, Football, football league, Ford Field, Georgia Dome, Gillette Stadium, graphs.net, Heinz Field, Hubert H. Humphrey Metrodome, infografía, infografica, infografik, INFOGRAPHIC, infographique, Lambeau Field, Lincoln Financial Field, LP Field, Lucas Oil Stadium, M&T Bank Stadium, Mercedes-Benz Superdome, Metlife Stadium, National, National Football League, National Football League Stadiums, O.Co Coliseum, Paul Brown Stadium, Qualcomm Stadium, Ralph Wilson Stadium, Raymond James Stadium, Reliant Stadium, Rogers Centre, Soldier Field, Stadium, Stadiums, Sun Life Stadium, University of Phoenix Stadium, Wembley Stadium
The United States of Energy [Infographic]
Auto, Business, Cheat Sheet, City, Economy, Education, Energy, Environmental, Guide, Industry, Life, Map, news, Plan, Quick Reference, Science, Technology, Tour
Source http://www. saxum .com/united-states-of-energy/
Hollywood Economics 2007-2011 [Infographic]
Cartoon, Cheat Sheet, Culture, Economy, Guide, History, Industry, Movie, news, Quick Reference, Tour
Source http://www. cilekagaci .com/2012/04/04/hollywood-economics/
26 Things to Note Before You Develop a Website [Infographic]
Cheat Sheet, Communication, Computer, Education, Guide, Interactive, Internet, news, Quick Reference, social, Web Design, Web Site
Source http://www. pixaal .com/scoops/26-things-to-note-before-you-develop-a-website/
How much do you cost? How much do you lose? [Infographic]
Business, Cheat Sheet, Communication, Computer, Guide, Industry, Interactive, Internet, Life, news, Quick Reference, social, Technology, Terror, Web Site
Source http://blog. kaspersky .com/windows-in-the-eye-of-a-cyber-storm/
1984 in 2013: Privacy & The Internet [Infographic]
Business, Cheat Sheet, Communication, Computer, Education, History, Industry, Interactive, Internet, news, social, Technology, Terror, Web Site, World
Source http://blog. hostgator .com/2013/04/23/1984-in-2013-privacy-the-internet/
Earth interior
western europe's history of jet fighter aircraft
Heart interior
dip stick geige
how big is your byte
Infographic, Data Visualization, Maps, Charts, Guides © 2019


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Home / Clinique
All Clinique perfumes can be found in this section.
Clinique Happy Cologne EDT for Men (100ml) (100% Original)
Happy Perfume by Clinique for Women EDP (100ml) (100% Original)
In 1968, Estee Lauder founded Clinique which is now one of the best cosmetics brands in the world. Encouraged by an article of Vogue magazine where a skin specialist talked about the value of skin care, Evelyn Lauder discussed the article with her mother-in-law, Estee, and also communicated with the beauty editor and the skin specialist who took part in the article. In August 1968 the Clinique collection was manufactured with their input and made its first appearance at Saks Fifth Avenue.
The company's items were the 1st cosmetics line to be allergic reaction tested and driven by the dermatologist. Nowadays, the goods are 100% fragrance-free. All goods in the product line proceed through comprehensive testing are held to accurate standards concerning allergic reactions.
"Clinique" is a French word which means "clinical" in English and the dermatological and clinical impression of the brand is more improved by the signature white laboratory coats worn by its product sales associates. Clinique's strategy is centered on the hygiene and cleanliness of the skin, and its three-step skincare techniques for different types of skin are one of its most significant beauty products.
Clinique also offers cosmetics and perfumes as part of its collection. The 1st Clinique perfume, Aromatics Elixir, was launched in 1971. This exclusive perfume has been a trademark fragrance for multiple generations of women. Regardless of the enduring recognition of Aromatics Elixir, the company's most popular and best-selling fragrance is actually Happy, launched in 1997.
This zesty citrus floral fragrance bounced into the national awareness by using a series of lively television advertisements featuring the Judy Garland track, "Come on Get Happy," which was mentioned to have encouraged its name. In the late 20th century, this name, the advertisements and the perfume hit a chord with American women. Bottles sold very rapidly as the perfume's appeal soared, and Happy would eventually create a men's version and a series of flankers. The very first edition of Clinique was launched in 1971 and the latest is from this year 2017.Getting Happy," which was mentioned to have encouraged its name.
Azzaro Chrome EDT for Men (100ml) (100% Original)
Prada Luna Rossa Sport EDT for Men (5ml, 10ml, 20ml, 100ml) (100% Original)
Dior Eau Sauvage Parfum for Men (5ml, 10ml, 20ml, 100ml) (100% Original)

redpajama_set_name: RedPajamaCommonCrawl


For the HSC eGuide, go to https://hscpass.health.unm.edu , and after signing in click on the "Update Profile" button. Make the changes and click "Update".
For the HSC Outlook Address Book, https://hsclink.health.unm.edu . After logging in, click on the setting gear icon in the upper right corner of the screen, then "Options". Click on "account", then "Edit information...". Change your information and save.
For the main campus directory, go to http://directory.unm.edu and click on "Update Your Info". Login and update your info.
You will have to call Main Campus IT if further assistance is needed in changing your Main Campus Directory info. because HSC does not support dss.unm.edu. The number for Main Campus IT is 277-5757.


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joana toro
joanatoro.com
Venezuela Exodus
Collectives:
Location: New York and Bogota
Nationality: Colombian
Biography: Joana Toro Colombian is a self-taught photographer based in both New York City and Bogota, Colombia. Her work explores issues of immigration, human rights and identity and was featured on The New York Times, Wall Street Journal, Smithsonian... read on
Focus: Photographer, Photojournalist, Journalist, Designer, Street Art, Documentary
Skills: Adobe Photoshop, Adobe Premier, Storyboarding
1 of 20 © 2020 Joana Toro
Venezuelan mother crosses the Simón Bolívar border point between Colombia and Venezuela to find supplies for her family on March, 2017 in Cucuta, Colombia.
Venezuelan family returns home to Venezuela after buying food supplies in Colombia on March, 2017 in Cucuta, Colombia.
Hundreds of people cross from Venezuela to Colombia through the Simon Bolivar border point to find medicines, food, supplies, or informal jobs on March, 2017 in Cucuta, Colombia.
Hundreds of people cross from Venezuela to Colombia through the Simon Bolivar border point to find medicines, food, supplies or to receive attention in Colombian hospitals on March 2017 in Cucuta, Colombia.
Consuelo Izagarra, 25, a Venezuelan woman who is the sister of Gerlimar Pastran, cares for newborn Juan Diego outside of the small room where the family is living in the La Libertad neighborhood on March, 2017 in Cucuta, Colombia.
Waiting room of the Villa del Rosario hospital which treats hundreds of pregnant Venezuelan women who have streamed into Colombia in recent months to have their babies, underscoring how the fast-deteriorating conditions of Venezuelan hospitals is putting a strain on the public health network in Colombian border towns on Friday March 10, 2017 in Cucuta, Colombia. (It is not certain how many of the women in this photograph are Venezuelans.)
A Venezuelan mother and her child receive instructions by the nurse of Villa del Rosario hospital about a vaccine for the child the father waits, hospitals in Cucuta can't attend the hundred of Venezuelans arriving on March, 2017 in Cucuta, Colombia
Front of building where the Pastran Rodriguez family lives in the La Libertad neighborhood on March 2017 in Cucuta, Colombia.
Gerlimar Pastran looks at her daughter outside of the small room where the family lives in La Libertad neighborhood on March 2017 in Cucuta, Colombia.
10 of 20 © 2020 Joana Toro
Esperenza Cumplido Rivera, a Colombian woman who is eight months pregnant moved back to Colombia after 14 years in Venezuela due to the lack of health services in Venezuela. Esperanza seen in her house in the La Concordia neighborhood in Cucuta, Colombia.
Esperenza Cumplido Rivera, a Colombian woman who is eight months pregnant moved back to Colombia after 14 years in Venezuela due to the lack of health services in Venezuela in front of her house in the La Concordia neighborhood on March , 2017 in Cucuta, Colombia.
Tachira River between Colombia and Venezuela
Boats in the midst of the sea, at San Fernando in Trinidad and Tobago.
A group of Venezuelan citizen are waiting to depart to Venezuela in Cedros port of Trinidad and Tobago.
Glenda Ablack 36, Venezuelan woman whit a master in Education who lives in Trinidad seven months ago, she is forced into long hours of work, as bartender and cleaning person in order to provide her family.
General view in Port-of-Spain the capital city of the Republic of Trinidad and Tobago.
Gina Lugo Venezuelan woman and her family are waiting for immigration process to leave Trinidad and Tobago in Cedros Port. Inside their bags they are transporting wheat flour,personal care products, milk ,coffee and oil.
La Havana local bar in Port-of-Spain streets. Trinidad and Tobago 2017
"Jorge" Venezuelan Chief Administrator living in Port-of-Spain two months ago, shows his daughter picture.
He leaves Venezuela after received death threats and had already been the victim of two assassination attempt, by The Bolivarian National Intelligence Service SEBIN. Jorge left her daughter in Venezuela and he has to start from nothing in Trinidad currently he sells middle Eastern food in Port-of-Spain streets.
Hundreds of people cross from Venezuela to Colombia through the Simon Bolivar border point to find medicines, food, supplies, or informal jobs every day.
March, 2017 in Cucuta, Colombia.
Credits: joana toro
Archived as: Venezuela
The United Nations Agency for Refugees, UNHCR, reveals that there are already more than 2.4 million Venezuelans who have escaped to several Latin American countries. Since Maduro came to power in 2013, the exodus of Venezuelans closes in 2018 exceeding one million in Colombia. The main reasons have to do with the fact that Colombia is the closest and easiest country for Venezuelans to go to. Around 118,000 Venezuelans are reported in Central America and Caribbean countries like Trinidad and Tobago.
This project documents the struggles of mothers and their families during this massive exodus.
joana toro Stories Venezuela Exodus
By joana toro —
Stament
By joana toro — Being an immigrant is an enormous challenge, this book provokes a reflection on the status of Latin immigrants in the US, their cultural..
By joana toro
Colombia on my mind
By joana toro — I was born in a country with an on-going civil war, just like my mother and grandmother. Colombia on My Mind is a personal journal that..
TRANSLATINA
By joana toro — This project is about the Latino Trans community in New York City. The Latino transgender community suffers from high levels of..
Nasa: Ancient Warriors.
By joana toro — The Nasa or Páez people, are an indigenous ethnic group, with an estimated population of 70,000 members, who mainly live in the department..
Agriculture and Habitat
Industry and Energy
Personal Fashion Portfolio
Afro-Colombian Midwives
By joana toro — Daily work of a guild of midwives in Colombia's Pacific Coast. I enter the midwives' association office in a humble neighborhood of..
Masked.
By joana toro — Masked (oodee, London, 2014) SOLD OUT San Martin, Meta is a town located in the middle of Colombia's eastern plains. Each year since the..
By joana toro — Colombia produces 55% of the world emerald market. These prized gems,considered the best in the world,have been the source of intrigue and..
for more access


New York, NY – The National Kidney Foundation (NKF) and the American Heart Association/American Stroke Association (AHA) announced a milestone collaboration to counter the epidemic of cardiovascular and kidney disease in the U.S. This partnership represents a major joint effort between these two longstanding health organizations to combat this public health problem.
NKF and AHA will launch their partnership in a joint hypertension awareness campaign called "The Domino Effect" on April 25th. Kicking off with a media tour the campaign will alert Americans to the hazards of uncontrolled high blood pressure and the major risk factor for stroke, heart attack, heart failure and kidney disease. This campaign underscores that complications associated with these conditions can be curbed or stopped through early detection and prevention.
NKF will also join AHA's Check. Change. Control.™ Leadership Community . The goal of the program is to help 13.6 million more Americans take control of their high blood pressure by 2020. "The Domino Effect" campaign partnership will coordinate and maximize both organizations' resources in highly visible national public awareness programs and educational initiatives.
"Bringing together the knowledge and resources of these two prominent, long-standing health organizations, marks an important step in our continued work to build healthier lives, free of cardiovascular disease and stroke," said Pablo A. Ortiz, Ph.D., Head of the Hypertension and Vascular Research Division at Henry Ford Hospital in Detroit, MI, and Chair of the American Heart Association Council on Kidney in Cardiovascular Disease.
One in three of us are at risk for kidney disease; one in nine of us have it; and only 10 percent know they have the condition. The rest will not know it until their kidneys fail and dialysis or a kidney transplant is needed to survive. These are the devastating statistics for kidney disease in the United States and the heart of the National Kidney Foundation's mission.
One in three American adults have high blood pressure. One in 3 deaths in the U.S. are caused by cardiovascular disease. An increase of just 10 percent in hypertension treatment would prevent about 14,000 deaths every year.
The National Kidney Foundation is the leading organization in the U.S. dedicated to the awareness, prevention, and treatment of kidney disease. For more information, visit www.kidney.org.
The American Heart Association is a national voluntary health agency whose mission is to build healthier lives, free of cardiovascular disease and stroke. For more information, visit www.heart.org.


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Evaluation of Carbaryl and Malathion Human Studies For Their
Proposed Application in a Physiologically-Based Pharmacokinetic
Model for Risk Assessment
EPA's Office of Pesticide Programs
List of Acronyms	3
1.0 Background and Introduction	4
1.1	Physiologically-Based Pharmacokinetic (PBPK) Modeling	4
1.2	Acetylcholinesterase Inhibition: Organophosphates and TV-Methyl Carbamates	6
2.0 Chemical Specific Reviews	7
2.1	Carbaryl	7
2.1.1	Summary of Toxicological Effects	7
2.1.2	Summary of Human Study	8
2.1.3	Utility of Carbaryl Human Data for PBPK Model	9
2.2	Malathion	9
2.2.1	Summary of Toxicological Effects	10
2.2.2	Summary of Human Study	10
2.2.3	Utility of Malathion Human Data for PBPK Model	11
3.0 Summary	12
4.0 References	13
AChE: Acetylcholinesterase
ADME: Absorption, Distribution, Metabolism, and Excretion
AOP: Adverse Outcome Pathway
DCA: Malathion Dicarboxylic Acid
DER: Data Evaluation Record
DMDTP: Dimethyl Dithiophosphate
DMP: Dimethyl Phosphate
DMTP: Dimethyl Thiophosphate
ECG: Electrocardiography
HED: Health Effects Division
HSRB: Human Studies Review Board
MCA: Malathion Monocarboxylic Acid
MO A: Mode of Action
NMC: TV-Methyl Carbamate
OP: Organophosphate
OPP: Office of Pesticides Program
PBPK: Physiologically-Based Pharmacokinetic
PD: Pharmacodynamic
PND: Postnatal Day
PoD: Point of Departure
RBC: Red Blood Cell
1.0	Background and Introduction
The purpose of this report is to present an overview of two different human studies to the Human
Studies Review Board (HSRB) for evaluation of their individual scientific validity. The human
studies that are presented are single oral dose studies for the active ingredients carbaryl and
malathion. The following are the citations for the human studies discussed in this report.
•	Carbaryl citation:
o May, D.G., etal. (1992). Cimetidine-Carbaryl Interaction in Humans: Evidence
for an Active Metabolite of Carbaryl. J Pharmacol Exp Ther. 262 (3) 1057-1061.
•	Malathion citations:
o Aston, L.S. (2000). Determination of residues of malathion dicarboxylic acid
(DCA), malathion monocarboxylic acid (MCA), dimethyl phosphate (DMP),
dimethyl thiophosphate (DMTP), and dimethyl dithiophosphate (DMDTP) in
human urine. Pacific Toxicology Laboratories, 6160 Variel Avenue, Woodland
Hills, CA 91367. PTL119801. October 11, 2000. MRID 45244601.
Unpublished.
o Gillies, D., Dickson, J. (2000). A randomised double blind ascending single oral
dose study with malathion to determine the no effect level on plasma and RBC
cholinesterase activity. Inveresk Research, Elphinstone Research Centre, Tranent,
EH 32 2NE, Scotland. ICR 013177. March 20, 2000. MRID 45125602.
These studies are discussed and evaluated in this document. In addition, this document explains
how the studies will be used to evaluate physiologically-based pharmacokinetic (PBPK) models
applicable to each1 as well as how the Office of Pesticide Programs (OPP) Health Effects
Division (HED) proposes to use these data in risk assessment.
Agency reviews of these studies have been summarized in the following data evaluation records
(DERs).
•	US EPA. (2016). Data Evaluation Record. Carbaryl Human Study. TXR# 0057550.
•	US EPA. (2016). Data Evaluation Record. Malathion Human Study. TXR# 0053266.
1.1	Physiologically-Based Pharmacokinetic (PBPK) Modeling
The relationship between an external dose of a chemical and its internal concentration is
determined by a set of chemical properties (e.g., solubility in blood and tissues, volatility,
binding affinity to proteins) and properties of the biological system (e.g., tissue volumes, blood
flows, metabolic capabilities). Computational models that describe these chemical,
physiological, and biochemical characteristics that are needed to predict a chemical's absorption,
distribution, metabolism, and excretion (ADME) behaviors are commonly referred to as
physiologically-based pharmacokinetic (PBPK) models. Since PBPK models incorporate
relevant biology that determines the ADME processes, they are not only useful for predicting
1 To clarify, EPA will consider the recommendations of the January 2017 HSRB as part of the basis of an evaluation
of the PBPK models for both carbaryl and malathion that EPA will complete. This evaluation and the associated
PBPK models will undergo external peer review in calendar year 2017.
internal dosimetry related to a certain chemical within specific testing conditions (e.g., dose
ranges, species, tissues), but also for extrapolating outside of the studied conditions. Such
capability makes PBPK models particularly useful in risk assessment where extrapolation to
varied exposure conditions is needed (e.g., consideration of doses well below those for which
data are available). PBPK models have been used to assist high-to-low dose, route-to-route, and
interspecies extrapolations necessary for estimating human risk on the basis of animal toxicity
studies or in vitro bioactivity data. The physiological structure of PBPK models also allows for
examining the effects of changing physiology, such as aging, early life-stage, or pregnancy.
The Agency recognizes the value of using PBPK models to predict internal target tissue doses
for risk assessment applications based on the assumption that similar tissue responses arise from
equivalent target tissue doses across species and exposure conditions. The 2006 EPA report on
Approaches for the applications ofphysiologically based pharmacokinetic (PBPK) models and
supporting data in risk assessment (US EPA, 2006) states that "PBPK model analysis is accepted
as a scientifically sound approach to estimating the internal dose of a chemical at a target site and
as a means to evaluate and describe the uncertainty in risk assessments." The report also states
that PBPK models intended for risk assessment applications should be evaluated for "model
purpose, model structure, mathematical representation, parameter estimation, computer
implementation, and predictive capacity." Specifically, for evaluating a model's predictive
capacity, the primary goal is to examine whether the model and corresponding parameters can
adequately simulate the available time course of tissue/blood data over a range of doses. This
process includes both model calibration, which means adjusting relevant parameter values to fit
the available data, and comparison to data that are not used to calibrate the model. A PBPK
model that simulates human ADME behaviors is often constructed without being calibrated
using human data. Often times, a parallelogram (or allometric scaling) approach is used to build
a PBPK model for humans from an animal model that has been calibrated and evaluated using
available data. In the rare case that human in vivo data are available, these observed tissue/blood
concentrations can be compared to model simulations to evaluate a human PBPK model's
predictive capacity. In the event in which model simulations do not agree with human data, the
modelers may decide to use the human data to calibrate the model which is the case in this
situation for carbaryl and malathion.
Specifically, for carbaryl, the data from the presented human study are only expected to be used
for establishing confidence in the human version of the model by comparing these human data
with model simulations. Time courses of both carbaryl concentrations in plasma and red blood
cell (RBC) AChE inhibition data will be used to evaluate the predictive capability of the carbaryl
PBPK-PD model. For malathion, the data from the presented human study are used for the same
purpose of examining whether the model can adequately simulate the human data. Time courses
of metabolites concentrations in urine, but not RBC AChE inhibition data, will be used to
evaluate the predictive capability of the malathion PBPK-PD model. If there are large
discrepancies between observed data and model simulations, these human data will be used to
adjust model parameters to calibrate the human version of the model for each chemical.
1.2 Acetylcholinesterase Inhibition: Organophosphates and iV-Methyl Carbamates
The information presented below is intended to provide context pertaining to how the PBPK
models that are under development will be used in risk assessment. The two chemicals
mentioned in the introduction that are the subject of this HSRB review are from two different
classes of pesticides, but both are known acetylcholinesterase inhibitors. Carbaryl is a A'-methyl
carbamate (NMC) pesticide and malathion is an organophosphate (OP) pesticide. There are
similarities and important differences between these two classes. The initiating event in the
adverse outcome pathway (AOP)/mode of action (MOA) for both classes is inhibition of the
enzyme acetylcholinesterase leading to accumulation of acetylcholine and ultimately to
neurotoxicity in the central and/or peripheral nervous system. However, the AOPs/MOAs are
differentiated by their action upon the active site of the enzyme, which results in clear
differences in the timing and duration of inhibition between the two classes.
NMCs inhibit AChE via carbamylation of the serine residue located in the active site of the
enzyme (see Figure 1). The NMC inhibition of AChE occurs via carbamylation of the serine
hydroxyl group results in a reversible binding process thus allowing for rapid reactivation of the
enzyme. The NMCs, therefore, have a unique mode of action that results in rapid onset and
recovery of the enzyme. The time to peak inhibition for NMCs is typically between 15 to 45
minutes while complete recovery of the enzyme is achieved within minutes to hours (US EPA,
2007). Therefore, for NMCs, including carbaryl, repeated daily exposure does not result in an
increased inhibition of AChE since enzyme recovery is complete before the next acute exposure,
and only acute exposure durations are a concern for neurotoxic effects.
Figure 1. Adverse outcome pathway for OPs and NMCs.
In contrast, OPs inhibit AChE via phosphorylation of the serine hydroxyl group at the active site
of the enzyme, which results in an irreversible inhibition of the bound enzyme. Inhibition occurs
within a few hours and continues until new, uninhibited enzymes are produced. This results in
the OPs exhibiting a phenomenon known as steady-state AChE inhibition. After repeated dosing
with an OP at the same dose level, the degree of AChE inhibition comes into equilibrium with
the production of new, uninhibited enzyme. At this point, the amount of AChE inhibition at a
given dose remains consistent across duration. Therefore, acute and steady state exposure
durations are of concern for OPs.
2.0	Chemical Specific Reviews
For carbaryl and malathion, a summary of toxicological effects is presented below followed by a
summary of the studies under review. Additional information can be found in the associated
DERs.
2.1	Carbaryl
Carbaryl is one of the most widely used broad spectrum insecticides in agriculture, professional
turf management, professional ornamental production, and in the residential lawn and garden
markets. For carbaryl, most of the toxicological studies were conducted in laboratory animals;
however, studies are available that involved direct dosing of humans with carbaryl.
2.1.1 Summary of Toxicological Effects
Based on the available data in laboratory animals, the nervous system is the primary target for
carbaryl and AChE inhibition is the most sensitive non-cancer endpoint in multiple species,
durations, lifestages, and routes. Oral, dermal, and inhalation studies that evaluate AChE
inhibition are available for carbaryl. Inhibition has been shown to be rapid, but also reversible
within minutes to hours. Therefore, repeated daily exposure does not result in an increased
inhibition of AChE since enzyme recovery is complete before the next acute exposure. As a
result, acute exposures are the exposure duration of concern for carbaryl neurotoxicity.
The carbaryl database for neurotoxicity is complete, with acceptable acute, subchronic, and
developmental neurotoxicity studies in animals. In the acute and subchronic neurotoxicity
studies in rats, clinical signs of toxicity were observed that were consistent with AChE
inhibition, including decreased motor activity, tremors, altered gait, decreased body temperature,
decreased arousal, pinpoint pupils, increased salivation, and decreased grip strength. Increased
inhibition of RBC, plasma, blood, and brain AChE was measured at the same doses that induced
clinical signs. Other effects in rodents, mostly at higher doses, included cataracts, degeneration
of sciatic nerve and muscle, pneumonitis, hepatocyte hypertrophy, and kidney disease.
Data are available describing the time to peak AChE inhibition and dose-response of carbaryl
brain and blood AChE inhibition in several studies in rats. The time from exposure to peak
AChE inhibition is well understood for carbaryl. Studies have found that peak inhibition occurs
within 30-60 minutes in adults and within 15-45 minutes in postnatal day (PND) 17 pups (E.
Reaves, 2007). The enzyme recovery half-lives estimated using the AChE inhibition time-course
data were 5.4 hours for PND 17 pups and 1.8 hours for adult rats. AChE activity was recovered
Figure 2. Structure of Carbaryl.
to pre-treatment levels in adult and juvenile rats within 24 hours. This is consistent with a
metabolism study that found slower metabolism of carbaryl in juveniles than in adults (Moser et
al., 2013). A comparative cholinesterase study is available for carbaryl that directly compares
the time to peak inhibition and magnitude of AChE inhibition in the young (both PND 11 and
PND 17 pups) to adults. The data demonstrate that PND 11 pups are more sensitive to carbaryl
than adult rats.
The complete toxicology database is available for carbaryl, including studies assessing
developmental, reproductive, and carcinogenic effects. However, these studies are not relevant
to the development or evaluation of the PBPK model.
2.1.2 Summary of Human Study
In a human study evaluating AChE inhibition resulting from carbaryl exposure (May, D.G., et
al., 1992), four non-smoking, drug-free normal males were dosed with carbaryl and at another
time with carbaryl following pre-treatment with cimetidine. Cimetidine is an Fh-histamine
receptor blocker that is known to reduce the activity of cytochrome P450 isozymes. Pre-
treatment with cimetidine was conducted to allow for the evaluation of the contribution of
cytochrome P450s to carbaryl metabolism. In vitro assays were also conducted; however, these
data will not be used for the PBPK model development, and therefore, are not discussed in this
White Paper. Details of the in vitro studies can be found in the study data evaluation record.
Carbaryl concentrations were measured in plasma at 0, 10, 20, 30, 45, 60, 90, 120, 150, 210, and
240 minutes following exposure, and the area under the plasma concentration-time curve was
estimated. Oral clearance was calculated. RBC AChE activity was determined at each time
point. This study did not measure any metabolites of carbaryl.
Following oral administration of 1 mg/kg carbaryl, the mean peak plasma concentration was 0.26
± 0.14 (J,g/ml at 30 minutes after exposure. The mean plasma half-life for carbaryl was 0.79 ±
0.47 hours in this study. The apparent oral clearance for carbaryl (5.4 ± 2.0 L/min) was greater
than would be expected for liver blood flow. The maximal reduction in RBC AChE activity (27
± 12%) was measured at 30 minutes after dosing. The RBC AChE activity recovery half-life
was approximately 2.6 ±1.5 hours, which was slower than the plasma half-life.
One week after the first dose of carbaryl, the same four male subjects were treated with 200 mg
of cimetidine every 8 hours for 3 days. On the third day, 1 mg/kg of carbaryl was administered
one hour after the last dose of cimetidine. Pre-treatment with cimetidine reduced the clearance
by 50% which resulted in a 2-fold increase in peak plasma concentration. These findings support
the hypothesis that the main site of metabolism for carbaryl is the liver by drug-metabolizing
enzymes that can be inhibited by cimetidine. Despite the increased systemic availability, the
concentration of carbaryl required to achieve a 20% inhibition of AChE activity increased by
over an order of magnitude in the presence of cimetidine.
For the purposes of the PBPK model, the carbaryl concentrations measured in the plasma and
AChE inhibition data from this study will be used to evaluate the predictive capability of the
model. There were no scientific issues identified during the review of this study (TXR#
0057550).
2.1.3 Utility of Carbaryl Human Data for PBPK Model
For the carbaryl PBPK-pharmacodynamic (PD) model for humans, the predictive capability of
the model will be evaluated using published time-concentration data of carbaryl in human
plasma, as well as AChE inhibition over time (May, D.G., et al., 1992). Specifically, the PBPK-
PD model will simulate carbaryl exposure following a single oral dose at 1 mg/kg to predict
carbaryl concentrations in plasma during and after exposure, up to 4 hours. The model will also
predict RBC AChE inhibition over the same period of time. Preliminary simulations have shown
reasonable agreement between model predictions and observed data. Thus, it is likely that no
further adjustment of model parameters will be needed as the model developers continue to
refine the model to account for life-stage differences. The OPP plans to use the human PBPK-
PD model to derive points of departure (PoDs) based on 10% RBC AChE inhibition for various
exposure scenarios (e.g., dietary exposure, drinking water exposure, residential exposure). As
described earlier, when fundamental biochemical processes are properly described in a PBPK
model, its primary power lies in its capability to extrapolate to species of interest and exposure
scenarios for which no pharmacokinetic data are available to characterize the relationship
between external doses and internal dose metrics. In the past, the Agency has used toxicity
studies conducted with laboratory animals for selecting PoDs for the carbaryl human health risk
assessment. The reference dose for risk assessment is based on an external dose that has been
administered to an animal and the default uncertainty factors to account for potential inter- and
intra-species differences. The use of the PBPK-PD model for carbaryl allows for the derivation
of an internal dose metric, which is a more accurate assessment of dose leading to an adverse
effects. This refinement reduces the uncertainty in extrapolation, and therefore, the uncertainty
factors incorporated into the reference dose used in risk assessment.
2.2 Malathion
Malathion is a non-systemic, wide spectrum OP insecticide. It is used in the agricultural
production of a wide variety of food/feed crops to control insects such as aphids, leafhoppers,
and Japanese beetles. It is also used in residential settings and in wide-area mosquitocide
applications. For malathion, most of the toxicological studies were conducted in laboratory
animals; however, studies are available that involved direct dosing of humans with malathion.
Figure 3. Structure of Malathion
2.2.1	Summary of Toxicological Effects
Malathion acts by inhibiting AChE in nerve cells, which is consistent with other OPs. This
inhibition leads to accumulation of acetylcholine and ultimately to neurotoxicity in the central
and/or peripheral nervous system. Clinical signs of neurotoxicity (such as, tremors, salivation,
urogenital staining, and decreased motor activity) can be found throughout the database of
experimental animal toxicity studies at doses higher (10-fold) than those causing AChE
inhibition.
Based on the available animal data, RBC AChE inhibition is the most sensitive endpoint for all
lifestages evaluated (adults, juveniles, pregnant dams, and fetuses) after oral and dermal
exposure. There are no sex differences regarding AChE inhibition. However, endpoints from
portal of entry effects (histopathological lesions of the nasal cavity and larynx) are shown to be
more sensitive than AChE inhibition after inhalation exposure.
Malathion, like some other OPs, requires metabolic activation to its oxon metabolite (malaoxon)
to inhibit AChE, with subsequent metabolism that leads to detoxification. Generally, absorption
and distribution are rapid with extensive metabolism and no accumulation in the tissues. The
steady state AChE inhibition is achieved after 11-15 days of exposure.
The complete toxicology database is available for malathion, including studies assessing
2.2.2	Summary of Human Study
In a randomized double-blind study (Gillies, D. and Dickson, J., 2000; Aston, L.S., 2000),
human volunteer subjects (27 males, 7 females, aged 18-50 years) were administered a single
oral dose (0.5, 1.5, 5.0, 10.0, or 15.0 mg/kg in gelatin capsules) of malathion (Lot No. 50913-01,
95.4% chemical purity) after completing a light breakfast. Control subjects (11 males, 3
females) received a placebo (lactose in gelatin capsule). The study was conducted in 7 treatment
blocks with ascending single oral dose of malathion. Vital signs and electrocardiography (ECG)
were measured on day -1, pre-dose (0) and at 2,4, 8, and 24 hours after dosing. Blood samples
were collected for hematology, clinical chemistry, plasma and RBC AChE activity measures, as
well as plasma levels of malathion and its metabolite malaoxon. Urine samples were collected
on all volunteers from 12 hours before dosing to 48 hours after dosing at -12-0, 0-12, 12-24, and
24-48 hour intervals and analyzed to evaluate the magnitude of five malathion metabolites:
malathion dicarboxylic acid (DCA), malathion monocarboxylic acid (MCA), dimethyl phosphate
(DMP), dimethyl thiophosphate (DMTP), and dimethyl dithiophosphate (DMDTP).
Results of the double-blind study with human volunteer subjects showed that there were no
significant treatment-related changes in vital signs, ECGs, hematology, clinical chemistry,
urinalysis or physical examination in any subject during the study. There were no significant
treatment-related effects on RBC and plasma AChE activities up to the highest dose tested (15
mg/kg). Although the statistical analysis on AChE activity was considered inadequate, it does
not change the conclusion of the study. At this time, the plasma and RBC AChE data are not
appropriate for use as a point of departure for risk assessment. Plasma levels of malathion and
malaoxon were both below quantifiable levels (<102 ng/mL and 99.8 ng/mL for malathion and
malaoxon, respectively) 1-12 hours after dosing in all male and female volunteers who received
15 mg/kg malathion or placebo, respectively.
Urine samples collected from the volunteers were analyzed with focus on the detection and
quantitation of malathion dicarboxylic acid (DCA), malathion monocarboxylic acid (MCA),
dimethyl phosphate (DMP), dimethyl thiophosphate (DMTP), and dimethyl dithiophosphate
(DMDTP) in human urine. The analyses showed that excretion of malathion residues occurred
primarily in the first 12 hours and generally increased with dose. MCA was the most prevalent
urinary component excreted over 48 hours followed by DMTP, DCA, DMP, and DMDTP.
Two additional studies (Scott, D. L., et al., 1999) described and validated the analytical methods
used for determination of malathion and malaoxon in human plasma and verified storage
stability of malathion and malaoxon in plasma samples in support of the study described above.
The GC method was validated by demonstrating adequate accuracy, precision, detection limits
and limits of quantitation. Limit of detection was 0.0002 ppm for DCA and MCA, and 0.0125
ppm for DMP, DMTP, and DMDTP. Limit of quantitation was 0.020 ppm for DCA and MCA,
and 0.025 ppm for DMP, DMTP, and DMDTP. Based upon established criteria for column
efficiency, precision, resolution, detection and quantitation limits, and intraday accuracy and
precision, the method was considered valid and appropriate.
For the purposes of the PBPK model, the only data from the malathion study that will be used
are the urinary metabolite concentration data. The AChE inhibition data mea^tf-ed-wi 11 not be
utilized. There were no scientific issues identified during the review of this study (TXR#
2.2.3 Utility of Malathion Human Data for PBPK Model
For the malathion PBPK-PD model for humans, the AChE inhibition data reported in the study
will not be utilized. Instead, the predictive capability of the model will be evaluated using
published urinary metabolite concentration data, specifically for MCA and DMP, as well as
plasma levels of malathion and malaoxon (Gillies, D. and Dickson, J., 2000; Aston, L.S., 2000).
The model will predict the time course of MCA and DMP concentrations in urine, and these
predicted values will be compared to the observed data to examine whether the human model is
capable of predicting malathion metabolism based on metabolism rates measured from the in
vitro system. The model will also predict the time-concentrations profiles for malathion and
malaoxon in plasma, which will be compared to the observed data. In the case which model
predictions do not agree with the observed data, the urinary metabolite data and plasma
concentrations for malathion and malaoxon (Gillies, D. and Dickson, J., 2000; Aston, L.S., 2000)
may be used to calibrate the model by adjusting model parameters (e.g., elimination rate
constants) to fit the human data. Similar to the case of carbaryl, the OPP plans to use the human
PBPK-PD model to derive PoDs based on 10% RBC AChE inhibition. The use of the human
PBPK-PD model provides a scientifically sound basis to extrapolate across species, routes, and
life-stages compared to the use of uninformative default uncertainty factors.
equivalent target tissue doses across species and exposure conditions. Currently, there are PBPK
models under development for carbaryl and malathion that will allow for the derivation of an
internal dose metric, reducing the uncertainty from extrapolating data from animals to humans
for human health risk assessment. In 2017, the PBPK models for both carbaryl and malathion
will undergo external peer review, and the findings of the January 2017 HSRB will be used as
part of the basis of the evaluation. The Agency's review determined that there were no scientific
issues with the human studies.
Aston, L.S. (2000). Determination of residues of malathion dicarboxylic acid (DCA), malathion
monocarboxylic acid (MCA), dimethyl phosphate (DMP), dimethyl thiophosphate (DMTP), and
dimethyl dithiophosphate (DMDTP) in human urine. Pacific Toxicology Laboratories, 6160
Variel Avenue, Woodland Hills, CA 91367. PTL119801. October 11, 2000. MRID 45244601.
Gillies, D., Dickson, J. (2000). A randomised double blind ascending single oral dose study
with malathion to determine the no effect level on plasma and RBC cholinesterase activity.
Inveresk Research, Elphinstone Research Centre, Tranent, EH 32 2NE, Scotland. ICR 013177.
March 20, 2000. MRID 45125602. Unpublished.
May, D.G., et al. (1992). Cimetidine-Carbaryl Interaction in Humans: Evidence for an Active
Metabolite of Carbaryl. J Pharmacol Exp Ther. 262 (3) 1057-1061.
Reaves, E. (2007). Carbaryl: Updated Endpoint Selection for Single Chemical Risk
Assessment. June 29, 2007. D337054.
Scott, D.L., Larner, J., Marshall, D.E., McGuire, G.M. (1999). Establishment and validation of
an analytical method for the determination of malathion and malaoxon in human plasma.
Inveresk Research, Tranent, EH 33 2NE, Scotland. Laboratory Report ID 17123. October 29,
1999. MRID 45125603. Unpublished.
Scott, D.L., Marshall, D.E., McGuire, G.M. (1999). Establishment and validation of an
analytical method for the determination of malathion and malaoxon in human plasma;
Addendum 1. Inveresk Research, Tranent, EH 33 2NE, Scotland. Laboratory Report ID 17123.
December 23, 1999. MRID 45125604. Unpublished.
US EPA. (2006). U.S. EPA. Approaches for the Application of Physiologically Based
Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment (Final Report). U.S.
Environmental Protection Agency, Washington, D.C.
US EPA. (2007). Revised N-Methyl Carbamate Cumulative Risk Assessment. U.S.
Environmental Protection Agency, Office of Pesticide Programs, Washington, DC.


Intelligent Connect is the mechanism the Filter Graph Manager uses to build filter graphs. It consists of several related algorithms that select filters and add them to the filter graph.
Read this topic if you are having trouble building a certain filter graph and want to troubleshoot the problem, or if you are writing your own filter and want to make it available for automatic graph building.
The IGraphBuilder::AddSourceFilter method adds a source filter that can render a specified file. First it looks in the registry and matches against the protocol (such as https://), the file name extension, or a set of predetermined check bytes, which are bytes at particular offsets in the file that match certain patterns. For details, see Registering a Custom File Type. Assuming that the method locates an appropriate source filter, it then creates an instance of that filter, adds it to the graph, and calls the filter's IFileSourceFilter::Load method with the file name.
The IGraphBuilder::Render method builds a subsection of a graph. It starts from an unconnected output pin and works downstream, adding new filters as needed. The starting filter must already be in the graph. At each step, the Render method searches for a filter that can connect to the previous filter. The stream can branch if a connecting filter has multiple output pins. The search stops when every stream has a renderer. If the Render method gets stuck, it might back up and try again, using a different set of filters.
If the pin supports the IStreamBuilder interface, the Filter Graph Manager delegates the entire process to the pin's IStreamBuilder::Render method. By exposing this interface, the pin assumes responsibility for building the remainder of the graph, down to the renderer. However, very few pins support this interface.
If the filter graph contains any filters with unconnected input pins, the Filter Graph Manager tries them next. You can force the Render method to try a particular filter by adding that filter to the graph before calling Render.
Starting in Windows 7, DirectShow has a list of preferred filters for certain media subtypes. If there is a preferred filter for the media type that is being rendered, the Filter Graph Manager tries that filter next. An application can modify the list of preferred filters by using the IAMPluginControl interface. Changes to the list affect the application's current process, and are discarded after the process ends.
Finally, if no suitable filter has been found, the Filter Graph Manager searches the registry, using the IFilterMapper2::EnumMatchingFilters method. It tries to match the output pin's preferred media types against media types listed in the registry.
Each filter is registered with a merit, a numerical value that indicates how preferable the filter is, relative to other filters. The EnumMatchingFilters method returns filters in order of merit, with a minimum merit of MERIT_DO_NOT_USE + 1. It ignores filters with a merit of MERIT_DO_NOT_USE or less. Filters are also grouped into categories, defined by GUID. Categories themselves have merit, and the EnumMatchingFilters method ignores any category with a merit of MERIT_DO_NOT_USE or less, even if the filters in that category have higher merit values.
Starting in Windows 7, DirectShow has a list of blocked filters for certain media subtypes. The Filter Graph Manager skips filters on this list. An application can modify the list of blocked filters by using the IAMPluginControl interface. Changes to this list affect the application's current process, and are discarded after the process ends.
Try filters in the graph.
Windows 7 or later: Try the preferred filter for the media type, if any.
Look up filters in the registry.
The IGraphBuilder::RenderFile method builds a default playback graph from a file name. Internally, this method uses AddSourceFilter to locate the correct source filter, and Render to build the rest of the graph.
Try a direct connection between the filters, with no intermediate filters.


No matter whether it is an induction, gas, glass or steel hob, it is one of the focal points of the kitchen. It can be installed over the top or recessed into it; either way it plays at matching or contrasting with the top's material and finish. Even the hub of the kitchen knows how to express its own, particular, personality.
The technological hob contrasts pleasantly with the textured appeal of the bush-hammered stoneware worktop.
Installed flush with the top the High Tech hobs in stainless steel are both original and discreet.
The countertop induction hob has three, in-line cooking zones: it is aesthetically refined and very easy to clean.
These burners, shown here with brass trims on a Dekton top, can be arranged as preferred and fitted directly into the worktop.


My recent convalescence has not prevented my continued acquisition of miniatures. I have two to showcase now, ones I have long coveted.
From Vesper-On for their game Carnevale, I managed to obtain their Plague Doctor. He seems to be in short supply at many online vendors, who are apparently expecting imminent restocks. Although the game is set in Venice at the end of the 18th century, I believe this costume/disguise/uniform works just as effectively for the end of the 19th. Reaper also has a Plague Doctor figure, but to me it looks practically modern in its dress.
The painted plague doctor from Vesper-On's website.
Also long on my must-haves list was Ingrid Rangvaldottir and her Mirror Golems, for Wolsung from Micro Art Studios. Despite the fact that she's depicted as elven but will be human in my Brass and Blood setting, I had to have her. I mean, look at those boots! And her automata are as adorable as can be. A little filing of those pointed eartips should do the trick.
The picture from Micro Art Studio's website.
My unpainted (as usual!) minis for Ingrid and her golems.
I also recently bought a piece of steampunk jewelry. I ordered my wife one of ThinkGeek's new Con Edition Bags of Holding and added this while I was shopping their site. It's their exclusive Capt. Jules' Extraordinary Telescope Ring. Here's a set of photos I took showing it in action.
but the largest fits my index finger. It's too big for my ring finger, which is a size 11 (U.S.).
Additionally, I have made some further steps in cementing my place on the Interwebz for Brass and Blood. "Establishing my brand" as it were. Sorry that none of it has yet appeared on the site, but that's next.
I first ordered some of the cards from Vistaprint that use their free templates. I got this nice vintage-looking card for Dispatches from the Rim, and a box of 500 cost me a little over $12 including shipping.
So this time I ordered a "premium" set from them. Several nice little touches -- the different background, the printed reverse side, a matte finish and a leather business card case -- added up to about $50, including shipping. Well worth it, and I think they turned out beautifully.
If you can't make out the text in my amatuer picture there, It says "www.brassandblood.com / Dark denizens vie for power in a steampunk London beset by the preternatural." The back of the card lists the main divisions of the storyline I've envisioned so far. You can think of them as novels in a trilogy or stages in a campaign, whichever -- because they're both. The "Tales of Brass and Blood" I have planned so far are "Black Blessings," "Bleak Beatitudes" and "Red Rapture." For more details, check the Brass and Blood website later this week.
Oh, and I also got my FLGS, Moxie Games, to order a Hordes Circle Orboros P3 paint set for me. So I promise, some painted minis soon! Or eventually! Or at least someday!
OK, cats and kittens, that's it for tonight. Back to the boards, everyone, and I'll see you across the table soon!
I love the mirror golems too, more than the girl figure in fact. Oh you had cards made!
I did indeed. I hope they have the impact I anticipated once I get to start passing them out.
Congratulations are in order on so many levels.
The plague doctor is a great figure and the telescope reminded me of similar such things found on the back of comics when I was a lot younger.
Thank you, sir. As for the telescope ring, I certainly hope it fares better than those sea monkeys I ordered from a comic book ad.
It's all looking good dude! Will there be zombies in "Brass and Blood"?
Of course there will, Bob! I absolutely love zombies and could not imagine creating a milieu that didn't at least have the POSSIBILITY of an invasion of the undead.
That ring looks awesome as do the mini's!
Thank you! Can't wait to get them assembled and get some paint on them.
The Carnevale stuff is really great looking, but some of the models are very fragile. It might not be your kind of thing, but the game is worth giving a go as well!
Thanks for the heads-up about the fragility of the Carnevale models. I have a copy of the rules but have never played it. I was even a backer of the doomed kickstarter had for a second volume.


text:
UCB Roundtable: Impact of Mike Shildt and Jeff Albert
@hes_verygood
by Rusty Groppel on March 18, 2019
While it's debatable just how much impact a manager — and especially a hitting coach — can have, it became apparent that the situation under Mike Matheny had deteriorated to the point of a clear negative impact on player performance, and ultimately wins and losses. Additionally, John Mabry, though he had some merits as an MLB hitter, rose to and retained his position mostly because of his widely-known-about friendship with the manager. His 5 1/2 year run is littered with regressive team and player trends that underlined the overall regression under Matheny.
This winter, although they haven't explicitly said as much, we can see the Cardinals almost treating the promotion of Mike Shildt — and the establishment of his system — similar to the acquisition of an impact player. Other side of that coin, the hiring of Jeff Albert has been touted to also bring on positive results. (Personally, I am in love with the Albert hire. I wrote about my wish for the hitting coach position immediately after they announced it's vacancy and he checked all of my boxes.)
Over the last 8 months, the contrast between the old and new regime is well defined.
And so, with that lengthy prologue, I ask: How much of an impact do you thing that Mike Shildt and Jeff Albert can truly have on the on-field product? What areas, specifically, will you be looking at most closely to find their fingerprints?
Daniel Shoptaw (C70 At The Bat): I think that Shildt and Albert will have an impact on the wins and losses of the team, but it's going to be on the margins. Perhaps a close game turns because Shildt goes to the bullpen a batter before Matheny would have. Maybe a batter gets a hit in a big spot because of his preparation with Albert that he wouldn't a have with Matheny (and Mabry). Here and there, I think the knowledge and preparation from these guys are going to help the players produce better. I don't believe they are worth 10 wins or so, though. The overall product will be better, but it's likely Paul Goldschmidt will have more impact on that.
Josh Gilliam (Pitchers Hit 8th): To be completely honest, I had two very different thoughts after hearing who the Cardinals had hired as hitting coach. Initially it was shock, because that meant Buda had been passed over for the permanent spot.
Once we all saw how the pieces fit, however, STL pulled off the potential steal of the winter with bringing Albert back to the organization. Buda is still on staff, but moving the page from Mabry to to a whole new method can only help the younger players.
Obviously, results have to be seen before conclusions can be made. But the Cards pulled out all the stops to make 2019 a much different outcome, with Albert as an important addition.
Mark Tomasik (RetroSimba): Regarding hitting coach Jeff Albert, I'm looking to see whether he can get the Cardinals batters to reduce their strikeouts and do a much better job of moving runners from first to third, from second to third with less than two outs, and from third with less than two outs.
Regarding Mike Shildt, I'm looking for a manager who gets players to buy into a team concept of play, who gets them to put team before self in their approach to the game and who has a clear philosophy that he's able to communicate. The model for me is Kevin Cash of the Rays. Cash is an innovator, who has a philosophy of how to play with the talent available and, most of all, he gets players to buy into his approach. What I don't want from Shildt is Pollyanna happy talk and I don't want a team that is run like a chapter of the Promise Keepers. Time will tell.
Kyle Reis (Birds on the Black): Great question, Rusty! I don't really know how to answer that when it comes to Mr. Albert. I find that I've been telling people that I want to see more contact with two strikes, but I don't know if that's something that Mr. Albert will be responsible for. During PaD (Prospects After Dark), I usually spew something about believing that how an adjusted approach for both Harrison Bader and Tyler O'Neill will be a litmus test, but it seems a bit presumptuous to think that a hitting coach is THE person that can remedy fundamental issues with a hitter's approach.
So what I'll say instead is, I don't know what to expect out of Jeff Albert, and I hope that I'll know it when I see it!
Mr. Shildt is a different story.
A lot has been made of Mr. Shildt's record after taking over as manager for Mr. Matheny. Going 41-28 is one heck of an accomplishment!! But that accomplishment, to me, is enhanced by an August that saw the Cardinals go 22-6. Entering August under Mr. Shildt, the Cardinals were 7-7. After August, the Cardinals were 12-15. They entered September in a Wild Card spot and with the second best record in the NL. It all fell apart because Mr. Shildt started to use the bullpen like Mr. Matheny did, and he continued to deploy a lineup that was struggling without mixing it up, even though the rosters had been expanded.
So, what I'll be looking for with Mr. Shildt, in an effort to understand the type of impact that he will have on his team, is if he uses his entire bullpen and the other options available to him on the 40-man, and if he's able to make the tough lineup decisions that are ahead of him. A lot has been made about Dexter Fowler and what should happen to his spot if he struggles. That's fair, but what if Mr. Bader struggles? Should he get two free months to work out his problems? What if Ozuna can't throw the ball or range because of his extra weight? Does he get nine innings every game, or is there a way to maximize his effectiveness with late inning defensive subs? Does he stick to the same lineup even if Carp and Goldy are the only players hitting? Will he have a quick hook with Cardinals legend Adam Wainwright if Mr. Wainwright is the early-2018 version of himself? What I'm saying is, I don't know what kind of manager Mr. Shildt is yet. But I know that there are tough decisions ahead of him to be made. How aggressive he is with those decisions, following a manager that was slow to make a change, is going to be the big test for me.
And THAT'S how you answer a question without answering a question!
And with that, we'll close the door on this session. Be on the lookout for other UCB Roundtable posts from other contributors.
Next Post: Playing Pepper 2019: Chicago Cubs
Previous Post: Playing Pepper 2019: Chicago White Sox


text:
Morsi supporters deprived of basic legal rights: Amnesty International
An Egyptian protestor hold a slogan symbolising the Rabaa al-Adawyia mosque sit in during clashes between supporters of the Muslim Brotherhood and Egypt's ousted president Mohamed Morsi and security forces, in Cairo, on August 30, 2013.
Amnesty International strongly criticised denied legal rights to detained supporters of ousted president Mohamed Morsi in a Thursday press release.
There have been several cases of protesters, according to the rights groups' documentation, in which detainees were not granted access to lawyers and relatives, "or an opportunity to challenge the lawfulness of their detention and their arrest."
"The failure of the Egyptian authorities to respect due process for people who have been arrested is a worrying sign," said Philip Luther, Amnesty International's Middle East and North Africa director. "…it is unacceptable for supporters of Morsi or the Muslim Brotherhood to be singled out for unfair treatment based on their political affiliations."
The press statement said Amnesty International was "concerned" that many of those arrested had not committed criminal offences, but were "merely exercising their right to freedom of expression and assembly by protesting in support of…Morsi."
"The way Egypt's judicial system deals with these cases will test whether it can truly perform its functions fairly and impartially, free from the influence of the executive," added Luther.
The group said that those arrested at the dispersals of Rabaa Al-Adaweya and Nahda Square were denied access to lawyers for at least four days and Muslim Brotherhood lawyers were not able to attend investigations because interrogations were carried out during curfew and in undisclosed locations.
Earlier this week, the Front to Defend Egypt (FDE) said that at least 3,059 protesters had been arrested in Cairo since Morsi's removal.
The group of independent lawyers reported difficulties in gaining access to detainees.
Amnesty International also said arrested protesters were sometimes not granted medical needs, including a woman with a broken leg who was held for four days before being taken to a hospital or seen by a doctor, with her requests to do so being rebuffed.
The press statement also said that at least 250 people were being held in Al-Salam Central Security Forces camp, an unofficial place of detention.
The Ministry of Interior's press office said that "all arrests were carried out according to decisions by the prosecutor general," and that arrest powers under state of emergency had still not been utilised by security forces.
Egypt's state of emergency, which was slated to last one month, was extended an additional two months on Thursday.
Groups including the Muslim Brotherhood have staged marches and protests since Morsi's ouster in early July and following the violent dispersal of Rabaa Al-Adaweyalast month. Security forces have arrested prominent Brotherhood members including Supreme Guide Mohamed Badie and his deputies Khairat El-Shater and Rashad Bayoumi, who all stand trial for killing protesters on 30 June in Moqattam.
The post Morsi supporters deprived of basic legal rights: Amnesty International appeared first on Daily News Egypt.


So far this year, the most fun that I have had in the theatre was yesterday at Victorian Lyric Opera's (VLOC) sensationally entertaining production of Gilbert and Sullivan's 1888 Yeomen of the Guard, or, the Merryman and His Maid, directed with overflowing frivolity by Catherine Huntress-Reeve. Two hours and forty-five minutes had never sped by so fast for me in the theatre, and at the end – like Oliver Twist – I wanted more!
Elsie Maynard (Amy Broadbent) and Colonel Fairfax (Michael Marano). Photo by Harvey Levine.
Filled with a giddy cast, a silly and entertaining story, a cast of exceptional singers, gorgeous costumes, and a 28-piece orchestra comprised of 28 fabulous musicians, conducted by the enthusiastic Musical Director Joseph Sorge, I knew I was in for an exceptional performance after the orchestra 'nailed' the overture. It displayed some heavenly playing – especially from Oboist Gwen Earle and bassoonists Steve Weschler and Betsy Haane, and I couldn't wait to hear them play the rest of one of my favorite W.S. Gilbert and Sir Arthur Sullivan's melodic masterful score. And they played it beautifully until the final curtain bow and until the final note was played.
And what a fabulous group of singers VLOC cast in this production. Amanda Jones (the overly touchy-feely sister Phoebe) sang angelic versions of "When maiden loves, she sits and sighs" and "Were I thy bride." The dashing Michael Marano (the almost-decapitated Colonel Fairfax) sang gorgeous renditions of "Is life a boon?" and "Free from his fetters grim." Blair Eig was hysterical as Wilfred Shadbolt, the jealous and keyed-up Head Jailer, and had the audience roaring with his "When jealous torments rack my soul" and "Hereupon we're both agreed" with Jack Point (Gary Sullivan). This hysterical duet received the loudest applause all afternoon. I would have loved a reprise or two!
Which brings us to the two performances I added a couple of "Bravos and Bravas" for at the curtain calls: Amy Broadbent (Elsie Maynard) and Gary Sullivan (Jack Point) – two travelling players who get caught up in a marrying scheme that goes afoul. Sullivan ias the 'Buster-Keaton-ish' Fool and Broadbent as the victim of a pile of coins and a punny and crazy Gilbert and Sullivan subplots.
I could go on and on but this would be the longest review in my career. Suffice to say that the rest of the cast was also having a great time with all the tongue-in-cheek lyrics and everyone contributed to the silliness and success of the production: Maureen Roult (Dame Carruthers);Joanna Jones (her niece);Andrew Pardin (Sir Richard Cholmondeley);James Carpenter (Leonard Meryll);Kevin Schellhase (First Yeoman) and Rand Huntzinger (Second Yeoman). And kudos to the excellent harmonies of the ensemble: Helen Aberger, David Berkenbilt, Harper Denhard, Ellen Sherfey, Lena Goldweber, Tara Hockensmith, Laura Hubbard, Ralph Johnson, Carl Maryott, Jane Maryott, Josh Milton, Rowyn Peel, Debbie Peetz, Bill Rogers, Barbara Semiatin, Stephanie Shade, Rusty Suter, Ed Vilade, George Willis, Maria Wilson, and Kent Woods.
Amanda Jones provided simple, yet elegant and humorous choreograph and Scenic Designer Catherine Huntress-Reeve built a simple yet effective set: two small residences with doors where all the 'going-ons' and going-offs' of the show occurred. And there were many of them!
Lighting Designer Andrew Dawson Smith gave everyone a special glow and Makeup/Hair Designer Renée Silverstone did Yeoman's work with the large cast. There is no credit in the program for the excellent sound-so kudos to you -whomever you are.
I didn't want to give away the story for those who have never seen this under-produced (which is a darn shame!) gem. But for those who aren't satisfied by this explanation, here you go – read the synopsis.
There is one more weekend for this superb production, so run and get some tickets and march over to Victorian Lyric Opera's divine Yeomen of the Guard. But be on guard – thy tummy may hurt after all the laughing and thy hands will ache after all the applause.
Note: There are very helpful surtitiles.
The Yeomen of the Guard or, the Merryman and His Maid plays on Friday, February 28th and Saturday, March 1, 2014 at 8 PM, and Sunday, March 2, 2014 at 2 PM, at F. Scott Fitzgerald Theatre in the Rockville Civic Center Park – 603 Edmonston Drive, in Rockville, MD. For tickets, call the box office at (240) 314-8690, or purchase them at the door, or online.
Victorian Lyric Opera's Production of Gilbert and Sullivan's 'The Yeomen of the Guard' Opens on Thursday, February 20th by Felicity Brown.


text:
TLC Postpone Tour Dates After T-Boz Suffers Allergic Reaction
By: London JennnCategory: News October 4, 2021
Two TLC tour dates had to be reshuffled after T-Boz suffered an allergic reaction to smoke backstage at one of their shows.
TLC has been on a nationwide tour with Bone-Thugs-N-Harmony, to commemorate their hit sophomore album 'CrazySexyCool." However, fans hoping to attend the upcoming dates in two Texas cities will have to wait a little longer to see the show.
On Saturday (October 2) the group announced that the Houston show wouldn't be going down that day and informed fans of the new date.
"TLC has rescheduled the Saturday, October 2nd show at the Smart Financial Center in Houston, TX to Monday, October 4th."
Giving reasons for the postponement the note continued: "Due to extreme cigarette and recreational smoke being present backstage at a previous show, T-Boz suffered an allergic reaction. The group has always enforced a strict no smoking policy at their shows in an effort to prevent any health related issues for the group and/or crew."
pic.twitter.com/X0nhqSR8ew
— TLC (@OfficialTLC) October 2, 2021
"All previously purchased tickets will be honored for the new date," the venue confirmed on Twitter.
TLC then announced that a second date would also be rescheduled: "TLC has rescheduled the Sunday, October 3rd show at the Pavilion at Toyota Music in Irving, TX to Tuesday, October 5th. We are so excited to see all our TLC fans there!!!"
See you on TUESDAY Dallas!!!! 😊😘😊😘 pic.twitter.com/kqPzShmWIm
T-Boz (Tionne Watkins) and Chilli (Rozonda Thomas) have been on tour since early September. T-Boz, diagnosed with sickle cell anemia as a child, spoke earlier this year about how the autoimmune disease affects how she manages her tour schedule.
"Early on, it wasn't managed at all," she said. "That's why I ruined every tour and got sick every time." T-Boz said she now works with her team to prevent any issues from arising.
"Everything is strategically planned out, as far as how long travel is, what days I'm off, and what cities we do or don't go to," she said.
Posted in NewsTagged Hip-Hop News, t-boz, TLC


H&K International School is an avid proponent of holistic child development through STEAM-based curricular education starting from early childhood. At H&K International School, we strive to create and develop an early childhood learning environment that nurtures creative, innovative, kind, talented, and responsible citizens. We believe that every single child is unique and develops at his/her own pace. Thus, we facilitate and help them mature to their fullest potential by recognizing their uniqueness and adopting a learning-through-play methodology, which is crucial to early childhood education. We take great care of our students and make sure no child is left behind. Our campus boasts a state-of-the-art facility with equipment and resources in several learning areas, including our very own "makerspace" with a 3-D printer and an interactive smart board, as well as a digital technology center and a STEAM corner. With exclusive access to such high-technology resources, our students are able to experience the joy and satisfaction of exercising their imaginations to design and create to solve real problems that plague our world today. We employ an internationally-recognized curriculum (International Early Years Curriculum) and supplement it with practical life skills education (STEAM Curriculum).


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Q: Java array index is n/2 I have a code that shows the Strassen Matrix Multiplication and I want to show its step by step process. The size and elements of the matrix are user-input. I have a problem with regards to showing the element at index (n/2). What should the indexes be when I show it? Thanks for the help!
Here's a part of my code:
else {
    int[][] A11 = new int[n / 2][n / 2];
    int[][] A12 = new int[n / 2][n / 2];
    int[][] A21 = new int[n / 2][n / 2];
    int[][] A22 = new int[n / 2][n / 2];
    int[][] B11 = new int[n / 2][n / 2];
    int[][] B12 = new int[n / 2][n / 2];
    int[][] B21 = new int[n / 2][n / 2];
    int[][] B22 = new int[n / 2][n / 2];

    split(a, A11, 0, 0);
    split(a, A12, 0, n / 2);
    split(a, A21, n / 2, 0);
    split(a, A22, n / 2, n / 2);

    split(b, B11, 0, 0);
    split(b, B12, 0, n / 2);
    split(b, B21, n / 2, 0);
    split(b, B22, n / 2, n / 2);

    System.out.println();
    System.out.println("Step by Step Operation");
    System.out.println();
    System.out.println("p1 = (" + A11[0][0] + " + " + A22 + ")(" + B11[0][0] + " + " + B22 + ")");
    System.out.println("p2 = (" + A21 + " + " + A22 + ")" + B11[0][0]);
    System.out.println("p3 = " + A11[0][0] + "(" + B12 + " - " + B22 + ")");
    System.out.println("p4 = " + A22 + "(" + B21 + " - " + B11[0][0] + ")");
    System.out.println("p5 = (" + A11[0][0] + " + " + A12 + ")" + B22);
    System.out.println("p6 = (" + A21 + " - " + A11[0][0] + ")(" + B11[0][0] + " + " + B12 + ")");
    System.out.println("p7 = (" + A12 + " - " + A22 + ")(" + B21 + " + " + B22] + ")");

redpajama_set_name: RedPajamaStackExchange


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Babaca Fanfics Sort of…
Babaca Fanfics
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Summer Anime Viewing
babaca July 13, 2014 Reviews
I'm still an anime fan. I love all kinds of anime, not just Mecha like Gundam. I enjoy sports anime (ones that are sports like soccer or tennis … not board games like Go or Shoji those are slow going for me. So below I will list what I'm watching this summer. All of it is on Crunchyroll. Crunchyroll will let you watch for free if you don't mind commercials or you can pay (with I do) so you don't have to sit through ads. If you want to try any of these titles out leave a comment and I could give you a code for 14 days of free trial of CR without the ads, until I run out of codes.
Let's go with the light as air, total fanservice anime:
Free! Iwatobi Swim Club ~ Eternal Summer
This is the second season of this anime of childhood friends who were part of a swim team. As they reached high school, their school didn't have a swim team so they worked at creating one.
There is conflicts, there's drama, there's lots of crotch shots of teenage boys which should make you feel shame, but it's done so damn cute that you don't feel like a complete pervert watching it. It's a short series, it will probably be 12 episodes like the first season, but it's one of those feel good shows that makes you want to hop in a pool and go swimming.
Speaking of sports, I didn't think I would like this one because I have no interest in Volleyball but damn if I didn't get sucked into Haikyu!!
Actually I believe this one started in the spring but I was bored waiting for summer fare and started watching a few days ago. You have Shoyo Hinata, a boy who was obsessed with volleyball. He saw a tournament on tv where someone as short as himself was called Little Giant and was a team hero. It inspired Shoyo to pursue volleyball the problem? His middle school didn't have a male volleyball team in middle school. He somehow managed to create a ragtag team to go to a tournament and they have to play one of the top teams in the tournament. Shoyo was pissed off at the superior attitude of the opposing teams setter, Tobio Kageyama, whose nickname was King of the Court. Shoyo's team gets beat handily but it doesn't discourage him, he joins the high school where Little Giant played. He also discovers that King of the Court also goes to the same school. The "king" got abandoned by his teammates during the tournament in middle school because of his bad attitude. Also the top volleyball schools rejected him because of his bad attitude.
They learn to get along and learn along the way that a short player who can jump high and loves to spike, and the perfectionist have the same goals. It's like most sports animes only without the "physics-free zone" of player moves.
Virtual Games… Sword Art Online II. This is the second season of this series. The initial series (the first half of it at l east) was a very cool story about people being trapped in a video game (through their virtual head gear) where the only way to leave the game was to finish it. There was no logging out and if you died in the game you died in real life. Kirito who was a beta tester before getting trapped in the game saved the day. The second half of the series was a different virtual world, one I wasn't crazy about for all sorts of reasons.
This season it's a third virtual world. It's call Gun Gale Online. Unlike the other worlds where there was swords and sorcerers, or fairies and wings, your goal is to shoot things. Some of the quest pays the players in real money. Someone by the name of Deathgun is killing players in the game and they are dying in real life. Kirito gets asked to join the game and see if he can see how Deathgun is doing this and stopping the guy if possible. So far I've only seen two episodes and I can't quite get into it. I'll try though. If I waded through the boring, stupid and borderline creepy second half, I might as well get through the rest of it. 😉
And now a little shonen ai/yaoi: This is based on a manga of the same name. Love Stage!!. Izumi Sena comes from a long line of entertainers. His father is a singer and owner of a talent agency, his mother is a popular actress, his older brother is a rock star and all he wants to be is a manga artist. Unfortunately he can't dr aw to save his soul. His one foray into show business was when he was a child and he got stuck filling in for an actress who couldn't come to the shoot for the commercial that his parents were in. He made for a cute girl in the commercial but he was hopeless as an actor, his young co-star in the commercial helped him through it.Cue: 10 years later the company who put out that commercial wants to do the commercial with the original cast. Izumi doesn't want to do it (he had to be bribed by his brother)
The young actor that was Izumi's co-star is now a popular actor. He wanted to work with the 'little girl' who was so nervous. Izumi is still an emotional wreck but Ryuichi helps "her" again with the acting job. So what happens when he discovers the little girl he has been crushing on for 10 years is really a guy?
Tweaking with themes…
YEAH! Fanfics are back!
What's Broken?
Don't Worry… It's still my site!
© 2019 Babaca Fanfics Sort of...


When most people mention reefs, they usually mean coral reefs, without realising that reefs can be extensive in cooler (temperate) waters.
Temperate reefs are highly productive and highly diverse (much more so than the more famous tropical reefs like the Great Barrier Reef), yet until quite recently, very little attention has been paid to them.
What is a temperate reef?


Turn even the simplest of refreshments into spotlight-worthy displays with the soothing backdrop of the Fischer Large Square Platter. Crisp white porcelain comes adorned with a delicate border and pretty pattern that's gradually revealed as your guests reach out for their favorite treats. From cupcakes to amuse bouche delights and even beverages, this charming platter helps serve it all with romantic charm. Feel great about entertaining each time as this sumptuous serving tray comes microwave, OTG and dishwasher safe.


We provide our valued principals with the very best in sales representation. There are no short cuts. Hard work, dedication and excellence in performance are absolute musts. The most important line we will ever have is our reputation and we guard it above all else. Only companies that take pride in the quality and worth of their products will be represented. We will, at all times, reflect credit upon ourselves, our organization, and the firms we represent.


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seadogs.com | The Official Site of the Portland Sea Dogs
Your Nine Inning Vacation
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Portland Sea Dogs News
Time to hand out the awards! Ockimey named team MVP
Kent Pitcher of the Year, Weems 10th Player, and Lovullo Citizen of the year
By Portland Sea Dogs | August 30, 2018 7:03 PM
Portland, Maine - The Portland Sea Dogs, the Double-A affiliate of the Boston Red Sox, presented their annual team awards before the season finale at Hadlock Field on Monday night. The team awards are voted on by the fans and are handed out in four different categories: Most Valuable Player, Pitcher of the Year, 10th Player, and Citizen of the Year.
Most Valuable Player - Josh Ockimey (.254, 15 HR, 56 RBI in 90 games)
Ockimey appeared in 90 games with the Sea Dogs from April 17-July 4, hitting .254 (79-for-311), 15 HR, 56 RBI, 19 2B, 2 3B, 59 BB, .370 OBP, and .473 SLG. Josh still ranks third in the Eastern League in walks and is among the Top 10 in on-base and slugging percentage. Ockimey had 15 multi-hit games and 12 multi-RBI games and blasted the team's first grand slam on April 19th vs. Hartford. Ockimey is a native of Philadelphia, PA and was drafted by the Boston Red Sox in the 5th round of the 2014 June Draft.
Pitcher of the Year - Matt Kent (11-8, 3.50 ERA in 26 games/22 starts)
Kent is tied for second in the Eastern League with 11 wins and ranks third in ERA at 3.50. Matt began the season as a reliever, compiling four scoreless appearances before becoming a full-time starter on May 6th. With his win on August 29th vs. New Hampshire, Kent became the first Sea Dogs starter to win four straight starts this season. Kent was an Eastern League All-Star and made his Triple-A debut with Pawtucket on July 26th. The Texas native is 11-8, 3.50 ERA (53 ER/136.1 IP) in 26 games/21 starts with 117 strikeouts.
10th Player Award - Jordan Weems (4-3, 4.14 ERA, 5 saves in 33 games)
Weems is just his third season as a pitcher after starting his professional career as a catcher from 2011-16. In 33 games with Portland this season, Weems is 4-3 (19 ER/41.1 IP) with 45 strikeouts in 33 games, going five-for-seven in save opportunities. The Georgia native has been scoreless in 23 of 33 outings with Portland, after starting his season in High-A Salem (0-0, 0.68 ERA). Weems made his Triple-A debut on July 29th with the Pawtucket Red Sox.
Citizen of the Year - Nick Lovullo
Lovullo volunteered for various community appearances at local schools and participated in multiple baseball clinics held at Hadlock Field. Nick could often be found at the autograph table in the concourse before games and signing more autographs along the picnic area and at the first base gate after games. Lovullo appeared in 58 games with the Sea Dogs this season, hitting .203 with 2 homers and 14 RBI. Nick was a 20th round pick by the Red Sox in the 2016 June Draft out of Holy Cross.
The Sea Dogs conclude the 2018 season on Thursday night, taking on the New Hampshire Fisher Cats (Blue Jays affiliate) at Hadlock Field.


For months, I felt like I had a third, very time-intensive part-time job. But man, was it WORTH IT. I can't emphasize how much delight and joy I get every time I walk through the archway between the dining room and kitchen (we had our contractor match the opening to the other archways in our home, and it feels like it's been there forever!).
We wanted to compliment the rich navy lower cabinets with a crisp, fresh, and timeless countertop and turned to Caesarstone's quartz surfaces (the stone is molded and pressed into slabs and is known for its durability). We opted for one of the colors in their 2017 collection called White Attica, which features gorgeous gray veining, and after much back and forth, and incredible guidance from our local fabricators, we opted to extend it all the way up to a full-height backsplash. Now that we've been living with it for several months, I can tell you that it was definitely a good choice for us. Granite and Marble Specialties recommended that we use the same slab for both the counter and backsplash (the fabricators cut the stone for us for the backsplash) in order to create a seamless transition. It's ridiculously easy to clean (I usually wipe down with a mixture of vinegar and water, then wipe clean with water) and makes the space feel so spacious.
We hope this kitchen will be the site of many new discoveries (both food and music-related) and we are thrilled to welcome you — virtually — into our home.


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@interface NavigationController : UINavigationController

@property (nonatomic,copy) NSString *naviBarBackName;

@end

redpajama_set_name: RedPajamaGithub


Another option is to explain this problem to Beth, and ask her to try to get in the habit of prefacing all verbal communications with you (that break a silence) by speaking your name first - as in, "Louis, would you turn the oven off?" By the time she gets past your name, you're listening & won't miss anything, thus eliminating the need for her to (frustratingly, for both of you) repeat herself, since hearing one's name has an instant "listen up!" effect.
On a side note, thank you for the heads-up on SBS; I didn't know about it. I know I suffer from tinnitus. (You're lucky you don't. It's not so bad when there's background noise, but some quiet nights, the silence is excruciatingly loud!). I also sometimes have trouble concentrating and sometimes, though not often, problems with balance, so maybe I also suffer from SBS. More research needed before deciding whether to consult with a medical expert.
But I'm glad if the SBS info is helpful (or even just educational).
That's a very interesting New Year's resolution. Thanks for posting this.


New and Selected Poems: 1957 – 2011 is culled from Robert Sward's newest and best works, including both previously unpublished poems and selections from his 20+ books of poetry. It is the definitive Sward collection, exhibiting throughout his signature style: outwardly zany and fanciful, but inwardly serious, troubled, and questioning. They cover the territory Sward has tread so well—love, divorce, multiple marriage, aging, loss, and the challenge of bringing up children in a highly unstable world.
When Robert Sward arrived in Santa Cruz in 1985, he instantly became the area's most nationally famous resident poet.


What is Pioglit Mf Forte Mg Tablet?
pioglit mf forte 30 Mg/500 Mg Tablet is a drug used to control high blood sugar levels in patients with type 2 diabetes. It is an anti diabetic drug. It makes the blood cells more sensitive to the action of insulin thus lowering the blood sugar levels in the body. It is used in combination with a proper diet and exercise program to maximize its effects. It also helps in preventing kidney damage, nerve problems and sexual problems. Controlling blood sugar level also helps reduce the risk of a heart attack or stroke.
pioglit mf forte 30 mg tablet is a drug used to control high blood sugar level in patients with type 2 diabetes. It is an anti diabetic drug. It makes the blood cells more sensitive to the action of insulin thus lowering the blood sugar level. It is used alongside a proper diet and exercise program to maximize its effects. It also helps in preventing kidney damage, nerve problems and sexual problems. Controlling blood sugar level also helps reduce the risk of heart attack or stroke. see the best pioglit mf forte price available at medypharma.
When is Pioglit Mf Forte 30 Mg/500 Mg Tablet prescribed?
pioglit mf forte 30 mg/500 mg tablet uses to control blood sugar levels in adults with Type II Diabetes Mellitus. The medicine is generally taken in conjunction with controlled diet and regular exercise.
In addition to its intended effect, pioglit mf forte 30 Mg/500 mg tablet side effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Take the missed pioglit mf forte dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Pregnancy – pioglit mf forte is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
breast-feeding – pioglit mf 15 alternative is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
Kidney diseases – pioglit mf 30 should be used with caution in patients with a known history of kidney disease due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Stress – Use of pioglar mf 15 should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.
Type 1 diabetes – pioglit 30 is not recommended for use in patients suffering from Type I diabetes since it is not effective in treating such patients.


Positive Behavior Interventions and Supports (PBIS) can be used to reinforce positive behavior at school. Research shows that proper PBIS training helps teachers create a positive school climate which consists of a safe, supportive learning environment that cultivates student success. Schools experience the following benefits when teachers are trained to use and measure PBIS initiatives: productive student engagement, positive student-to-student and student-to-teacher relationships, higher test scores, decreased absenteeism, higher graduation rates and a stronger sense of school identity and community.
In order for schools to reap benefits from positive intervention programs, there must be a focus on PBIS training and implementation. Systems must be used with fidelity and practiced with excellence in order to maximize student impact. School leaders can ensure success by providing teachers with adequate professional development to guarantee that PBIS systems thrive in schools.
How Do Schools Provide PBIS Training to Staff?
School leaders should strategically consider the types of character traits and behavioral habits that will contribute to the academic goals at hand, then develop systems that support the nourishment of these behaviors. Having clarity around the behavior expectations of students further reveals what teachers will need to do to support student achievement. With a clear vision of necessary teacher actions and skills, school leaders can develop a professional development plan that trains teachers to increase their effectiveness in using PBIS strategies.
Creating a year-long plan for PBIS training will ensure that each best practice is adequately studied and implemented. School leaders can be creative when prioritizing specific PBIS initiatives over others. The key is to find PBIS initiatives that support the cultural vision of the school and prioritize them in a way that is manageable.
Schools should work with PBIS experts in order to ensure that staff is given the highest level of training. This could be internal school administrators, outside agencies, or peer groups. Kickboard has helped many schools turnaround student behavior by providing professional development services to support PBIS initiatives.
How Can Schools Provide One-on-One Teacher Training and Support for PBIS Initiatives?
Teachers should always be able to identify the current focus PBIS strategy and how aligned goals are being measured and monitored for effectiveness. Another tip is that they should be able to depend on a specific level of support from their instructional coaches and school administration. Clarifying how teachers will be supported will not only ensure that goals are met, but it can develop full team accountability and investment.
Create a rubric that clarifies what excellence looks like in the classroom. Break down the teacher and student behaviors that you want to see. For example, the rubric may describe what effective redirection looks like in action while also clarifying the appropriate student participation.
After PBIS training sessions focused on strategies take place, instructional coaches and school administrators should informally observe classes to see how teachers are doing with Tier I PBIS initiatives. PBIS rubrics can be used during these classroom visits. In debrief meetings, highlights and areas of growth should be discussed.
Write a positive note to a few students every day.
Make positive parent phone calls to highlight the hard work of at least one student in every class per day.
Shout out at least one student at the end of class for their hard work. Make sure to pick a different student each day and use a tracker to keep track of who you have already highlighted.
PBIS trainers should help teachers practice habits that will lead towards growth in areas of improvement.
Teachers appreciate acknowledgement for their work and effort, just like kids do. School leaders should intentionally match PBIS priorities with teacher incentives. This allows teachers to be highlighted for the work they are doing to impact students, and it also builds enthusiasm around PBIS goals.
Each teacher can be measured on how well students are meeting PBIS goals.
Teachers can get public acknowledgment for successful PBIS initiatives in their classroom.
Teachers can spend time popping into each other's classrooms to share love or gain inspiration.
What Should Schools Expect When Training Teachers in a PBIS School?
There are a variety of PBIS strategies a school can focus on. The key is ensuring that everyone is on the same page about what the priorities are and how PBIS training and systems should be implemented. Simply put, teachers need to know what to do and how to do it. Here are a few essential professional development training tips and topics schools can use to empower teachers in PBIS classrooms.
Effective praise is positive validation of what a student is doing right. When used effectively, this strategy can promote positive classroom behavior. Teachers should practice what effective praise looks and sounds like as well as what it doesn't look or sound like. This will ensure that teachers accurately use the strategy to support student behavior.
Teachers should review best practices for rewarding students for their positive behavior. Rewards should be presented in a way that reinforces the type of behavior schools want to see. Teachers can acknowledge students of the day, week, or month, post academic work to highlight success, or allow students to earn a special celebration. Use this list to find more free or inexpensive ways to reward students.
Redirecting student behavior requires practice. Teachers must practice what to say and how to say it. Word choice and tone may impact how a student responds when being redirected. Additionally, teachers must talk through how to use least invasive strategies to redirect students. For instance, using gestures and proximity decreases how often a student is verbally redirected. Redirecting student behavior can be best practiced using scenarios and role play.
Schools should consider how they will keep track of the student behaviors. Having a clear, consistent way of recording and analyzing student behaviors will provide clarity into which students are progressing and who is in need of extra behavioral support. Additionally, it will help teachers clarify how effectively they are implementing PBIS strategies. Kickboard's Positive School Culture Inventory reveals a list of the most impactful behaviors schools can track.
PBIS training should be strategically included in a school's professional development plan. If a school decides to make Positive Behavior Interventions and Supports a priority, the school leader and administration team must be prepared to support teachers with these initiatives. And just like students, adults thrive from positive reinforcement, acknowledgement and support. Additionally, schools should continue to expect teachers to have strong relationships and engaging instruction in classes. This works hand in hand with PBIS strategies to insure that students are invested and exhibit positive classroom behavior that promotes student achievement.
Here at Kickboard we have seen many schools turnaround student behavior by using our PBIS mobile app, web platform, and professional development services to support their PBIS initiatives.


Here is a video compiled by the PUMA PAC Mensheviks. I suggest everyone view this blasphemous filth in order to become better acquainted with those who stand in the way of the Messiah.
May they all burn in the fiery unionized furnaces of New Jersey for their sins against the Obama!
This can only be the work of one person. Who can that be? The Master of Evil and Chaos, Rush Limbaugh!! May his RethugliKKKan soul burn in the Pit of Neverending Hope!!
Unbelievable! Where's the beet? Didn't the Empress win Texas? That blasphemer at the end talking about how important it is that everyone uses a system that they can depend on....she is right, Obama uses a system that they could depend on that everyone uses in Chicago. Off with their heads!
I think a better title for this video would be "The taste of our own medicine"
The enemy of my enemy is always my friend, Comrade Red Square.
Outragous claims! Such blasphemes deserve a forced trip to the Gulags!