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Alagille Syndrome
Subscribe to New Research on Alagille Syndrome
A multisystem disorder that is characterized by aplasia of intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC), and malformations in the cardiovascular system, the eyes, the vertebral column, and the facies. Major clinical features include JAUNDICE, and congenital heart disease with peripheral PULMONARY STENOSIS. Alagille syndrome may result from heterogeneous gene mutations, including mutations in JAG1 on CHROMOSOME 20 (Type 1) and NOTCH2 on CHROMOSOME 1 (Type 2).
Alagille Syndrome 1; Alagille Syndrome 2; Alagille Watson Syndrome; Cardiovertebral Syndrome; Cholestasis with Peripheral Pulmonary Stenosis; Hepatic Ductular Hypoplasia, Syndromatic; Hepatofacioneurocardiovertebral Syndrome; Watson Alagille Syndrome; Watson Miller Syndrome; Watson-Miller syndrome; Alagille Watson Syndromes; Arteriohepatic Dysplasias; Cardiovertebral Syndromes; Dysplasias, Arteriohepatic; Hepatofacioneurocardiovertebral Syndromes; Syndrome, Alagille; Syndrome, Alagille Watson; Syndrome, Cardiovertebral; Syndrome, Hepatofacioneurocardiovertebral; Syndrome, Watson Alagille; Syndrome, Watson Miller; Syndromes, Alagille Watson; Syndromes, Cardiovertebral; Syndromes, Hepatofacioneurocardiovertebral; syndrome, Watson-Miller; Arteriohepatic Dysplasia; Dysplasia, Arteriohepatic
Networked: 178 relevant articles (3 outcomes, 10 trials/studies)
Digestive System Diseases: 46
Liver Diseases: 25816
Intrahepatic Cholestasis: 1061
Alagille Syndrome: 178
Hepatic ductular hypoplasia: 56
Biliary Tract Diseases: 336
Bile Duct Diseases: 62
Cholestasis: 5369
Cardiovascular Diseases: 37259
Cardiovascular Abnormalities: 279
Congenital Heart Defects: 1340
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 668
Congenital Abnormalities: 15467
Multiple Abnormalities: 163
Inborn Genetic Diseases: 842
1. Cholestasis
2. Liver Diseases (Liver Disease)
3. Intrahepatic Cholestasis
4. Hypercholesterolemia
5. Gallstones (Gallstone)
1. Hadchouel, Michelle: 7 articles (11/2007 - 09/2002)
2. Kamath, Binita M: 4 articles (08/2012 - 10/2002)
3. Spinner, Nancy B: 4 articles (06/2012 - 10/2002)
4. Meunier-Rotival, Michèle: 4 articles (11/2007 - 01/2003)
5. Arnon, Ronen: 3 articles (12/2014 - 08/2010)
6. Whitington, Peter F: 3 articles (12/2014 - 06/2002)
7. Kerkar, Nanda: 3 articles (12/2014 - 08/2010)
8. Piccoli, David A: 3 articles (02/2012 - 10/2002)
9. Driancourt, Catherine: 3 articles (11/2007 - 05/2005)
10. Hadchouel, M: 3 articles (02/2001 - 09/2000)
Drugs and Important Biological Agents (IBA) related to Alagille Syndrome:
1. VitaminsIBA
11/15/1990 - "Early recognition of the ocular changes in arteriohepatic dysplasia is helpful in establishing the proper diagnosis to avoid unnecessary abdominal surgery and institute vitamin therapy."
2. terthienyl (alpha-T)IBA
02/01/2001 - "We investigated the efficacy of alpha-T supplements for preventing lipid peroxidation in patients with Alagille syndrome, according to the severity of cholestasis. "
3. progressive familial intrahepatic 1 CholestasisIBA
11/01/2015 - "Total biliary diversion as a treatment option for patients with progressive familial intrahepatic cholestasis and Alagille syndrome."
10/01/2014 - "Of the 12 children, 10 had progressive familial intrahepatic cholestasis (PFIC) and 2 had Alagille syndrome (AS). "
01/01/2008 - "Partial External Biliary Diversion (PEBD) is a surgical intervention to treat children with Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille syndrome (AGS). "
11/01/2004 - "In addition, four patients with progressive familial intrahepatic cholestasis and three with Alagille syndrome were also included. "
11/01/2012 - "We recruited a total of 23 pediatric patients receiving conventional FSV supplementation in a single medical center, with diagnosis of biliary atresia (10), progressive familial intrahepatic cholestasis (9), Alagille syndrome (2), and other conditions (2). "
4. CholesterolIBA
02/02/2015 - "To characterize cholesterol regulation in the liver of patients with Alagille syndrome (AGS). "
02/02/2015 - "Negative feedback loop of cholesterol regulation is impaired in the livers of patients with Alagille syndrome."
09/01/2004 - "SR-BI- and ABCA1-mediated cholesterol efflux to serum from patients with Alagille syndrome."
01/01/2003 - "Five children with Alagille syndrome and basal serum cholesterol concentrations greater than 230 mg/dL were included. "
01/01/1989 - "Children with Alagille syndrome show high serum cholesterol (15-20 mmol/L). "
5. Cholestyramine Resin (Questran)FDA LinkGeneric
01/01/2003 - "Under the conditions of the current study, no significant effect of variable doses of cholestyramine could be demonstrated on the serum lipid profile of a series of children with Alagille syndrome. "
06/01/1995 - "Five children (mean age = 6 +/- 4 years) with Alagille syndrome were studied at two different times while receiving no treatment, and while receiving cholestyramine. "
01/01/1982 - "Arteriohepatic dysplasia: a 16-year follow-up during treatment with cholestyramine."
01/01/2003 - "The objective of this study was to evaluate the effect of cholestyramine on the serum lipid profile of a group of children with Alagille syndrome and hypercholesterolemia. "
01/01/2003 - "Lack of cholesterol-lowering effect of graded doses of cholestyramine in children with Alagille syndrome: a pilot study."
6. ApolipoproteinsIBA
04/01/2000 - "Apolipoprotein E polymorphism in alagille syndrome and progressive familial intrahepatic cholestasis."
04/01/2000 - "The aim of the study was to assess the apolipoprotein E polymorphism (apoE) in two familial cholestatic diseases-Alagille syndrome (AS) and progressive familial intrahepatic cholestasis (PFIC)-and to estimate its association with gallstone formation, cholesterol levels, and response to UDCA treatment. "
06/01/1995 - "The aim of the study was to assess the lipid profile (plasma lipoproteins, apolipoproteins (apo)) and lecithin cholesterol acyl transferase (LCAT) activity, with and without treatment with cholestyramine in Alagille syndrome. "
7. Hepatic ductular hypoplasiaIBA
06/01/1981 - "Syndromatic hepatic ductular hypoplasia (arteriohepatic dysplasia): a clinical and hepatic histologic study of three patients."
09/01/2000 - "The strong JAGGED1 expression during human embryo- and feto-genesis both in the vascular system and in other mesenchymal and epithelial tissues implicates abnormal angiogenesis in the pathogenesis of Alagille syndrome and particularly the paucity of interlobular bile ducts. "
01/01/1995 - "Fatty acid (FA) concentrations were studied in lymphocytes isolated from children with syndromic paucity of interlobular bile ducts (PILBD), Alagille syndrome. "
01/01/1995 - "Fatty acid content in lymphocytes from children with syndromic paucity of interlobular bile ducts, Alagille syndrome."
06/01/1981 - "This constellation of defects constitutes a distinct syndrome to which the terms arteriohepatic dysplasia and syndromatic hepatic ductular hypoplasia are applied. "
8. Lipoproteins (Lipoprotein)IBA
10/01/1996 - "The lipoprotein profiles of 22 patients with Alagille syndrome were determined and the findings were compared with the severity of jaundice. "
10/01/1996 - "Abnormal lipoprotein pattern in patients with Alagille syndrome depends on Icterus severity."
06/01/2008 - "Fluctuation of lipoprotein metabolism linked with bile acid-activated liver nuclear receptors in Alagille syndrome."
03/01/2005 - "To evaluate the risk for atherosclerosis in Alagille syndrome (AGS) and progressive familial intrahepatic cholestasis (PFIC) on the basis of lipoprotein metabolism and by ultrasonography. "
03/01/2005 - "Evaluation of risk for atherosclerosis in Alagille syndrome and progressive familial intrahepatic cholestasis: two congenital cholestatic diseases with different lipoprotein metabolisms."
9. LecithinsIBA
06/01/1995 - "Lipoprotein pattern and plasma lecithin cholesterol acyl transferase activity in children with Alagille syndrome."
07/01/1987 - "The glomerular lesions observed in Alagille syndrome are strikingly similar to those observed in adults with lecithin-cholesterol acyl transferase deficiency and other conditions characterized by an increase in plasma lipoproteins rich in free cholesterol and in phospholipids. "
10. Neprilysin (Neutral Endopeptidase)IBA
11/01/2007 - "Serum neutral endopeptidase activity (NEA) has been recommended as a marker of cholestasis in adults but not in children with Alagille syndrome (AGS). "
08/01/2002 - "The aim of this study was to determine whether neutral endopeptidase activity is elevated in serum in children with cholestatic liver disease (Alagille syndrome), and whether the enzyme cooperates with the serum aminopeptidase-M in degradation of peptides. "
1. Liver Transplantation
08/27/1995 - "These results indicate that the quality of life can be considerably improved after liver transplantation in children with a severe hepatic form of Alagille syndrome and suggest that it could be carried out before these children attend elementary school."
04/01/2014 - "This study was carried out in Chang Gung Memorial Hospital-Kaohsiung Medical Center, Taiwan, with the aim of reviewing the characteristics and the outcome of liver transplantation (LT) in children with Alagille syndrome (AGS). "
08/01/2012 - "Outcomes of liver transplantation for patients with Alagille syndrome: the studies of pediatric liver transplantation experience."
08/27/1995 - "Liver transplantation in children with Alagille syndrome--a study of twelve cases."
09/20/2014 - "Treatment of cardiovascular complications of Alagille syndrome in clinical optimization for liver transplantation."
10/01/2012 - "Multidisciplinary management of a hepatic and renal transplant patient with Alagille syndrome."
12/01/2006 - "Two children were weaned from long-term tube feeding after liver transplant because of Alagille syndrome. "
05/01/2011 - "CDD reconstruction was used in patients who received a liver transplant for a diagnosis of PSC, congenital hepatic fibrosis, biliary atresia, and Alagille syndrome. "
10/01/2005 - "From these eleven cases, the indications for liver transplant were acute liver failure (ALF) in seven, biliary atresia in three, and Alagille syndrome in one. "
07/01/2002 - "A 13-year-old girl with Alagille syndrome presented with oral manifestation of end-stage liver disease that needed liver transplant. "
01/01/2010 - "Still, patients with Alagille syndrome present with only slight catch-up growth after transplantation, while patients with PFIC and biliary atresia grow significantly.<br />"
07/27/2001 - "Between 1984 and 1997, among 444 pediatric liver transplant recipients, 17 had liver transplantation for Alagille syndrome (mean age 3.5 years, range 1.2-13 years), mainly because of poor quality of life with intractable pruritus, and failure to thrive. "
04/01/2001 - "It is unusual to see the clinical picture of hepatic failure resulting in cirrhosis and requiring transplantation, but liver transplantation is indicated in Alagille syndrome patients who have chronic cholestasis. "
09/01/2002 - "The mean waiting time on the transplantation list was 6.1+/-8.9 months and the main indications for the procedure were biliary atresia, inborn metabolic disorders, liver cirrhosis, liver neoplasms, Alagille syndrome, and fulminant hepatic failure. "
03/01/2005 - "The main indication for primary transplantation was biliary atresia (10), followed by Byler's disease (2), acute liver failure on cryptogenetic cirrhosis (1), and Alagille syndrome (1). "
4. Anesthesia
01/01/2007 - "Alagille syndrome and anesthesia management."
03/01/2005 - "Anesthesia for a child with Alagille syndrome."
05/01/2005 - "[Anesthesia in intrahepatic cholestasis: Alagille syndrome]."
5. Total Parenteral Nutrition
10/01/2013 - "Other diagnoses included neonatal hepatitis, total parenteral nutrition cholestasis, Alagille syndrome, cystic fibrosis, choledochal cyst, hypothyroidism, alpha-1 antitrypsin deficiency and persistent cholestasis of unknown etiology. "
07/28/2014 - "In this review, we will discuss some of the atypical causes of cholestatic liver disease such as benign recurrent intrahepatic cholestasis, progressive familial intrahepatic cholestasis, Alagille Syndrome, biliary atresia, total parenteral nutrition induced cholestasis and cholestasis secondary to drug induced liver injury. "


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text:
Paul Ryan's Job Is Now On the Line if AHCA Fails
Sydney Robinson
Amid a growing frenzy in Congress over the postponed vote for the American Health Care Act is the looming threat against Speaker of the House Paul Ryan's very livelihood. As the health care bill continues to sink, many are beginning to wonder if it is a sign that Ryan should not be at the helm in the House as well.
President Trump was asked today during a brief press gaggle if he felt Speaker Ryan should remain in his position if the AHCA failed to pass. Willing to remain publicly loyal to Ryan for now, at least, Trump said "yes."
Privately, Trump is reportedly regretful that he ever publicly supported Ryan's brainchild healthcare bill at all.
According to the New York Times,
"Mr. Trump has told four people close to him that he regrets going along with Speaker Paul D. Ryan's plan to push a health care overhaul before unveiling a tax cut proposal more politically palatable to Republicans.
He said ruefully this week that he should have done tax reform first when it became clear that the quick-hit health care victory he had hoped for was not going to materialize on Thursday."
Still, if the bill does die on the House Floor, there is no telling who Trump will throw under the bus to protect himself. Already, he has begun blaming Congress as a whole, but if the bill does fail as it seems it will, he may need a bigger target for the GOP to focus on.
In fact, according to sources who spoke with Bloomberg, Trump's White House is already setting the stage to place the entire blame on Ryan.
"I think Paul Ryan did a major disservice to President Trump, I think the president was extremely courageous in taking on health care and trusted others to come through with a program he could sign off on," Chris Ruddy, CEO of Newsmax and a long-time friend of Trump's, said in an interview last week. "The President had confidence Paul Ryan would come up with a good plan and to me, it is disappointing."
Blaming Ryan does seem to be the smartest option for the take-no-responsibility POTUS. After all, Ryan was the architect of the badly-formed, universally opposed healthcare bill.
Clearly, the rising star of the GOP who was once a Vice Presidential candidate and has proudly served as the Speaker of the House may have simply bitten off more than he can chew, and in this Administration, there is no reward for failure.
Sydney Robinson is a political writer for the Ring of Fire Network. She has also appeared in political news videos for Ring of Fire. Sydney has a degree in English Literature from the University of West Florida, and has an active interest in politics, social justice, and environmental issues. She would love to hear from you on Twitter @SydneyMkay or via email at srobinson@ringoffireradio.com
Corporate Media At It Again As They Churn Up War With Iran
Trump Jr. Spreads Insane Conspiracy That Ukraine Ambassador Spied On Him

redpajama_set_name: RedPajamaCommonCrawl


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Although the sun is very hot, but it was very cool under the tunnel. I really enjoyed being in it while listening to the rush of the waves that swept the sands.
I loved to stay longer at Liang Tarsusu beach, but the owner of the ship reminded me to immediately go before the sea water become recede. If the tide is low, the boat cannot sail, and we will be stuck on the beach for a long time. Ended up with a heavy heart I left liang tarussu beach and went to Janeyya beach.
After sailing for 20 minutes to the north, we arrived at the beach. I thought, there was no difference between Janeyya beach and Malemalea Beach. Only a white sandy beach with many palm trees behind. Nothing special. Fortunatelly the boat owner knew my disappointment, then he took me to see 2 caves around the beach.
We walked for 30 minutes through the red soil where there are a lot of rocks to get the cave. I was exhausted and painstakingly followed the boat owner to keep up. He walked fastly, and I get amazed with his bare feet that walked on the sharp rocks without felt pain.
The first cave we encountered was a vertical-mouthed cave. There's water in the middle. I thought that it's connected with the sea. And it reminded me to a film titled Sanctum, a film about sea cave in Papua new Guinea.
From this cave we moved to the second cave. we had to walk again for 30 minutes, through the sharp rocky soil, bush, and a lot of mosquitoes. I felt so tired, but I was curious.
Finally we got it. Such as the first cave, there's water at the ground of this cave, but for me this is more beautiful because there's stalactites and stalagmites.
There are many bats that live and hanging on the walls of this cave. they fly and sang when I made noise by shouting and clapping.
I didn't want to miss this moment, so I asked the owner of the boat to take a photo of me.
When we returned to the beach, the sea has receded. we weren't able to continue the journey to the north to reach the last beach, Ballojaha. The boat owner tried hard to push the boat to the sea, and then we sailed to the south.
The boat owner offered me to get the last beach through the land and I agreed. Then he took me to his home in fishing village on the east coast of the Gusung Island. From his home, we went to the beach by motorcyle.
Sailing to the fishing village seemed so long because we had to sail around the island and the waves was high. I didn't know exactly how long us against waves. I was dizzy, so I tried to fall asleep. When I woke up, I was glad that we had arrived.
Many fishponds around the east coast of Gusung Island.
When I was in the village I didn't took photos because too many people were looking at me with a strange.
Whereas during a way to the beach, I was busy balancing myself on a motorcycle that is driven on uphill and down and winding streets. But I felt that I had to take a panorama of blue sea, although with the fear of falling down.
30 minutes later, we arrived at the Ballojaha Beach. It's a long coastline, white sandy, with the forest and rocks as the background.
We stopped to take a picture after we out of the woods. At the northern end of the island I saw a pig out from the woods onto the beach. But it immediately go when we tried to be close.
At the north end of the west coast of gusung island, there is an odd hole. When the ocean tide, the water will be sucked into the hole and form a vortex. But when the sea recedes, it emits cold water that flows into the sea.
The sea was receding when I was there. The water that is coming out of the hole made a gurgling sound. Here I tried to take another picture with different angle.
This pattern is created by water that flowing to the sea.
Again, I got amazed, how trees can live on a rock?
There are also a lot of holes and rock debris such as at Liang Kareta Beach.
when I looked around the sea, I felt peace. Always love the blue sky.
Day was getting late in the afternoon and the moon began to appear.
We returned to the village, and saw a fisherman who was tying up his boat.
From the fishing village on the east coast of the Gusung island, I went back to the pier in Padang Village by boat, then take the minibus to Kota Benteng, the capital of the Selayar islands.
Been a few months since my adventures in gusung island. Every inchs of its beauty is still there in the memory. It's a memorable trip indeed.
Wow!!! The pictures are absolutely awesome, Mak, great combination with the traveler. Agreed with Mba Evi's words : wonderful place, brave traveler and great pictures! TFS, Mak Noe.
Looks like an amazing place to explore… and not much touristy as well, right?
Widiiih, aku belajar banget dari klan Nurul di KEB.


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Man killed in Jupiter car crash
Updated: 11:20 AM EDT May 12, 2012
A man was killed after running a red light in Jupiter early Saturday, police said.Anthony Dale Evans, 30, of Jupiter, failed to yield at a red light and crashed into another vehicle at Central Boulevard and Indiantown Road about 12:30 a.m. Saturday, police said.Evans was ejected from his pickup truck and was pronounced dead at the scene.The driver of the second vehicle was treated for minor injuries at Jupiter Medical Center and was released, police said.
JUPITER, Fla. —
A man was killed after running a red light in Jupiter early Saturday, police said.
Anthony Dale Evans, 30, of Jupiter, failed to yield at a red light and crashed into another vehicle at Central Boulevard and Indiantown Road about 12:30 a.m. Saturday, police said.
Evans was ejected from his pickup truck and was pronounced dead at the scene.
The driver of the second vehicle was treated for minor injuries at Jupiter Medical Center and was released, police said.


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Suffering an on-the-job injury can be just the beginning of a very difficult time for an injured worker. The injury may prevent you from returning to work. The lost wages and the uncertainty about your future at your job can create serious stress. Financial challenges can spring up overnight when your income stream is interrupted.
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For centuries the sound of a tea spoon being tapped against a wine glass at a wedding reception has signalled the moment when the speeches begin. The father of the bride, followed by the groom, and finally the best man, have cleared their throats, knocked back their drinks and got to their feet. But the closed shop has been broken. It's no longer just the men who have all the fun; more and more brides are coming out from behind the top table and are speaking for themselves.
I am firmly of the opinion that no one, especially the bride – it is your day after all – should speak if they really don't want to. But your wedding reception is a golden opportunity. It will almost certainly be the only time this group of people will ever be gathered in the same room together, and therefore the only chance you'll have to speak to everyone and pay tribute to your husband in your own words.
♥ There are no rules. Because there are no set-in-stone customs for the bride's speech it can be anything you want it to be.
♥ Don't wing it. Even if you only plan to say a few words, make sure you have planned, prepared and practised what you want to say.
♥ Keep it brief. Especially if yours is in addition to, rather than instead of one of the other speeches, the shorter it is the greater the impact it will have: less is more.
♥ Tell a story. If you want to say how supportive your parents have been, how great your bridesmaids are and how wonderful your new husband is, tell a story to illustrate each point. It will make what you are trying to say more vivid and memorable.
♥ The day belongs to you. You are the main event, the star attraction… but be gracious about all that everyone has done for you and they'll love you even more.
♥ Talk about the boy. The one story that all the guests want to hear is how you fell for the love of your life.


Nice work, thanks for sharing such great work, keep more post dude bookmarked your site and visit again in my near future.
information??? INFORMATION?? Are you kidding me??? duh!!
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text:
Canoe, Alter Domus Form Strategic Pact
Editorial Staff November 10, 2021
Canoe said its automated technology for alternatives and private markets will streamline Alter Domus' ability to collect and categorize documents, extract, validate and deliver data to downstream systems.
Canoe Intelligence, a US fintech firm working with wealth managers, capital allocators and other firms, has announced a strategic partnership with Alter Domus, which provides integrated solutions for alternative investment firms.
Under the pact, Alter Domus – with a total of $1.3 trillion of assets under administration – will modernize and bring scale to its existing alternative data management and asset servicing businesses. Canoe's technology will help Alter Domus to collect and manage data in a more streamlined way.
The partnership follows Canoe's acquisition of Strata Fund Solutions LLC earlier in 2021. In September Canoe completed a financing round led by private equity big-hitters Carlyle and Blackstone, both of which are Canoe's clients. Canoe was founded in 2013 within Portage Partners to streamline its operations and was spun out in late 2017 with funding from a select group of investors, clients, and advisors. Canoe became a commercial entity in 2018.
Canoe competes with organizations such as Private Client Resources, among others. The business of collecting, processing and reporting on investments in alternatives such as private equity, hedge funds and real estate has expanded rapidly as capital has flowed into these areas over the past two decades. Low yields on listed equities and government bonds amid ultra-low interest rates have fueled the popularity of private markets.
However, these areas have traditionally been challenging for wealth managers seeking to report back to clients. ALTSMARK, a US software solution firm for the private capital sector, earlier this year said that more than a third of registered investment advisors could be put out of business within a decade if they don't include alternative assets in their clients' portfolios. Private market investments – such as private equity and credit – have exploded 30-fold from 2000 to $30.5 trillion today.
Family Office Members Want Fast Data – Time To Step Up Pace
Wanted: "All Rights Reserved" For NFTs
An Overview From EY On Tech Traps Facing The Sector
Crypto Assets, Distributed Finance And Wealth Managers' Menus
Undisclosed Digital Assets? - Decision Time Is Now
Boost Advice's Added Value With Goal Monitoring
Emigrant Partners Makes Another Minority Stake


A great wall decal for any party room is a present! Removable holiday wall stickers come in a set of 4 for you to arrange however you would like. Holiday presents wall decal is shown in light blue, but is available in all of our colors.


With the arrival of the New Year comes the start of a new round for the Writing Challenge! This time, the topic is "Song and Silence", as decided by last round's winner, Chief Petty Officer Radi Rais of the USS Victory. Nov./Dec. saw a fantastic turnout in terms of entries, so let's see if we can get even more this time? Always thought about entering, but not got round to it? Been a while since you submitted something? Drop by the Writing Challenge forum and submit your story today!


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Kaye Lanning Minchew, Troup County Archives,
Located in west central Georgia, about seventy-five miles southwest of Atlanta and forty miles northeast of Columbus, Manchester sits at the intersection of Georgia 85 and U.S. 27 in the southern tip of Meriwether County. According to the 2010 U.S. census, Manchester has a population
of 4,230, making it the largest city in the county.
Named for the industrial city in England, Manchester was incorporated in 1909. The planned city had come into existence in 1907 when the Atlanta, Birmingham, and Atlantic (AB&A) Railroad chose the site as the junction of its main rail lines to Atlanta and Birmingham, Alabama, and built extensive rail yards and shops there. Fuller E. Callaway, an industrialist in nearby LaGrange, soon announced he would build a textile mill in the new town. Callaway and others had lobbied to get the AB&A into west Georgia and LaGrange to give the long-established Atlanta and West Point railroad competition in hauling freight. By 1909 the Manchester plant of Callaway Mills opened and began producing textile products.
Pig Barbecue
In the 1960s Milliken bought the plant, which was a major employer in the area until it closed in 1985.
Prior to 1907, only a few homes stood in the area. The Manchester Development Company, with Callaway as its treasurer, was organized to sell building lots for $75 each to prospective residents. By 1912, just three years after incorporation, Manchester had become the largest city in the county, with new homes, businesses, and schools under construction.
Recreational facilities were soon developed and operated originally by the YMCA and later the Callaway Educational Association. Churches were also established. Callaway Mills provided a union church for all denominations, and soon after its establishment, Baptist, Methodist, and Presbyterian churches sprung up. Other denominations followed.
The city's two earliest schools were private. To accommodate the growing population, Manchester established a public school system. Those schools are now part of the Meriwether County School System. The Pine Mountain Regional Library has its headquarters in Manchester with a branch in Greenville, the county seat.
Manchester lies just four miles southeast of Warm Springs, famous for its rehabilitation center and its frequent guest Franklin D. Roosevelt, who sought treatment for his polio there. Roosevelt's visits often brought him to Manchester. On the evening of October 2, 1928, he was speaking to a group there when New York Democrats tried to reach him by telephone to ask him to run for governor
of New York, his home state, which he ultimately agreed to do. He won that post, and four years later, he was elected president of the United States.
Popular fiction writer Stuart Woods is one of Manchester's most famous sons. His maternal grandfather, William Henry Callaway, served as chief of police in the 1910s and 1920s. Woods left Meriwether County after attending public schools and set his first novel, Chiefs (1981), in the fictionalized town of Delano, which shares many similarities with his hometown of Manchester. The Mystery Writers of America awarded Chiefs its Edgar Allen Poe Award in 1982 for best first novel.
Callaway Family
Callaway Foundation
More in Cities & Towns
Ellaville
Millen
Media Gallery: Manchester
Segregated Railroad Station
Callaway Mills, Aerial View
Larry Goolsby, Atlanta, Birmingham and Coast (Valrico, Fla.: Atlantic Coast Line and Seaboard Air Line Railroads Historical Society Inc., 2000).
Regina P. Pinkston, Historical Account of Meriwether County, 1827-1974 (Greenville, Ga.: Gresham Printing Co., 1974).
Donna Jean Whitley, "Fuller E. Callaway and Textile Development in LaGrange, 1895-1920" (Ph.D. diss., Emory University, 1984).
Minchew, Kaye L. "Manchester." New Georgia Encyclopedia. 20 July 2018. Web. 17 January 2020.
Digital Library of Georgia: Sanborn Fire Insurance Maps
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Troup County
Colquitt
Fort McAllister
Charles Counts (1934-2000)
George Warren
Desegregation of Higher Education
Charles Crisp (1845-1896)
Johnny Mercer (1909-1976)
Keith Maltbey (b. 1959)
Southern Polytechnic State University
Donald Bryan (1921-2012)
Rich's Department Store


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Featuring Nicolas Reyes and Tonino Baliardo
09 April 2020 Brisbane Convention and Exhibition Centre
12 April 2020 State Theatre, Sydney
15 April 2020 Canberra Theatre Centre
16 April 2020 Palais Theatre, Melbourne
18 April 2020 Riverside Theatre PCEC, Perth
World renowned flamenco, rock and pop musicians, The Gipsy Kings featuring Nicolas Reyes and Tonino Baliardo, the original songwriters and guitarists on hits such as 'Bamboleo', 'Volare' 'Djobi Djoba' and 'Bem Bem Maria' are returning to tour Australia this April!
The band who captured the world's imagination 25 years ago went platinum with their self-titled debut album and became a genuine world music phenomenon with the hit 'Bamboleo'. Since then, the band have gone on to perform live in every corner of the globe and sold over fourteen million albums worldwide. Their compilation The Best of Gipsy Kings was in the charts for over a year.
In their native Gipsy language 'gitane' they introduced listeners to a unique, irresistible blend of traditional flamenco styles, vigorous guitar work and passionate vocals; this indigenous traditional style is known as "rumba flamenca".
Over the years The Gipsy Kings—whose members hail from the gypsy settlements in Arles and Montpelier in the south of France—have included singers and guitarists from the Reyes (Canut, Nicolas, Pablo and Patchai) and Baliardo families (Diego, Paco and Tonino). Lead singer Nicolas Reyes is the son of famed Flamenco singer José Reyes, who, with Manitas de Plata, sold millions of records in the 1960s and 70s.
As founding members, songwriters and singers – Tonino Baliardo and Nicolas Reyes hold the torch and continue The Gipsy Kings long family tradition. Don't miss this high-energy celebration!


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Toni Stephenson Lymphoma Center
Modifying CAR T Cells to Increase Transplant Effectiveness: Hematologist Leslie Popplewell, M.D., is building on the success of her two recent phase 1 clinical trials where she found that infusing transplant patients with modified T cells that target lymphoma was safe and did not interfere with transplanted bone marrow cells. Based on the promising results from her trials, Popplewell has illustrated that the design of chimeric antigen receptors (CAR) in T cells may determine the potency of the body's immune response against cancer cells. Currently, she is awaiting an amendment which will allow her to further modify the CAR T cell to improve longevity thus halting disease progression and increasing the effectiveness of bone marrow transplants.
Novel nucleotide-based approaches for the treatment of lymphoma: Elizabeth Budde, M.D., Ph.D., working together with Marcin Kortylewski, Ph.D., and Hua Yu, Ph.D., from Beckman Research Institute of City of Hope, is developing first-in-human immune-based therapies targeting both lymphoma cells and the suppressive tumor immune microenvironment. This project uses two alternative oligonucleotide-based approaches, CpG-STAT3 siRNA and CpG-STAT3 decoy oligonucleotide, to simultaneously target the cell surface TLR9 receptor and the critical transcription factor STAT3, in both lymphoma cells and in immunosuppressive myeloid cells. This project is funded by the Lymphoma SPORE.
Using Technology to Improve Peripheral T Cell Lymphoma Outcomes: John Chan, M.D., co-leader of the Hematology Malignancies Program, and recently appointed Dr. Norman & Melinda Payson Professor in Hematologic Cancer, successfully identified gene expression signatures that can classify subtypes of peripheral T cell lymphoma (PTCL). This discovery prompted funding from the National Cancer Institute which allowed him to begin translating his findings to a platform suitable for widespread clinical applications. This project will benefit physicians by providing them with a tool to make a more accurate diagnosis of PTCL for clinical trials and treatment. Using a powerful DNA-sequencing technology, Chan has begun categorizing mutations in PTCL and identifying mutations that drive disease development and progression. By analyzing these mutations, he hopes to identify specific genes in tumors that are potentially targetable for treatment. In addition, Chan recently partnered with Dr. Muhammed Murtaza from the Translational Genomics Research Institute (TGen) to develop a liquid biopsy assay on plasma from patients in order to have a sensitive non-invasive assay for diagnosis and follow-up management. Funded by the TSLC, this research has the potential to improve patients' quality of life and represents one of our first examples of applying the promise of precision medicine to lymphoma patients.
Developing a novel antibody therapy against drug-resistant B cell lymphomas: Larry Kwak, M.D., Ph.D., and Hong Qin, M.D., Ph.D., have developed monoclonal antibodies against the B cell activating factor receptor (BAFF-R). These antibodies, generated using a natively folded BAFF-R protein, showed a remarkable anti-tumor activity against established tumors in vivo and primary patient samples. Drs. Kwak and Qin are now performing IND-enabling studies in order to bring this discovery to a first-in-human clinical trial. Despite the development of new drugs, patients who develop resistance to first-line therapeutic agents often die of their disease. Because they show great efficacy against drug-resistant tumors at the preclinical stage, these BAFF-R antibodies could provide an alternative therapy for patients who progress or relapse after initial treatment. This project was selected by the Strategic Portfolio Optimization Committee (SPOC) for manufacturing and regulatory support through the Hope Portfolio Fund, which accelerates development of breakthrough new drugs to first-in-human clinical trials.
Additionally, team of TSLC investigators, led by Kwak, recently received one of only two prestigious awards from the Leukemia & Lymphoma Society (LLS) resulting in a $2.5 million grant with an additional $2.5 million committed by City of Hope. The Toni Stephenson Lymphoma Center's support enabled his preliminary studies involving the development of new antibody-based therapeutics to control mantle cell lymphoma (MCL) which made his receipt of this award possible. Kwak plans to build upon his prior work by exploring the use of combining CAR T cell immunotherapy, which is already approved for another type of non-Hodgkin lymphoma, with targeted agents such as ibrutinib.
Restoring the Immune System to Conquer Cutaneous Lymphoma: As director of the Cutaneous Lymphoma Program, Christiane Querfeld, M.D., Ph.D., seeks better treatment options for cutaneous T cell lymphoma (CTCL), a rare form of lymphoma that appears on the skin, but can also spread to the lymph nodes and internal organs. Through her investigations, Querfeld has demonstrated that CTCL growth is fostered by the surrounding nonmalignant cells. These observations have led to the initiation of several targeted and immunologic therapies to restore the immune system thereby killing the cancerous cells.
Identifying biomarkers for response to treatment to brentuximab vedotin: Joo Song, M.D., Robert Chen, M.D. and Alex Herrera, M.D., are mapping the biomarkers affected by brentuximab vedotin — a drug used to treat relapsed Hodgkin lymphoma — and other cancer inhibitors. Identifying which biomarkers are associated with response or resistance to brentuximab vedotin will enable physicians to prescribe this therapy to patients most likely to benefit from this treatment.
Targeting B Cell Lymphoma: Wendong Huang, Ph.D., professor in the departments of Diabetes Complications & Metabolism and Molecular & Cellular Biology, seeks to understand the molecular changes that lead to either T cell or B cell lymphomas in order to create better, more effective treatments. uilding on his previous research into the effectiveness of targeting CAMKII — a key player in the development of lymphomas — to prevent and treat T cell lymphoma, Huang's group is now expanding their findings to B cell lymphoma. Their results indicate that a similar but distinct pathway is required for the development of B cell lymphoma. In addition, his group is actively designing treatments that utilize different natural products to target this pathway to efficiently destabilize c-Myc protein, thereby bringing lymphoma under control. These discoveries were published in the July 2017 issue of the prestigious medical journal, Cancer Cell. In order to further this novel research that moves City of Hope one step closer to developing more effective treatments for both T cell and B cell lymphoma, Huang was awarded one of five 2018 TSLC Pilot Grants.
In addition to Dr. Huang's work on B cell lymphoma, Markus Müschen, M.D., Ph.D., and Gang Xiao, Ph.D., discovered a new therapeutic target for B cell malignancies called PP2A. They found that deleting the PP2A gene in B cell lymphoma and leukemia cells eliminated those cells while sparing normal cells. There is currently a clinical trial at City of Hope that uses a drug, LB-100, to target this pathway. Müschen's team published their research, which also shows promise for patients battling certain autoimmune diseases where B cells are involved, in the prestigious scientific journal Cell. In a landmark advance for City of Hope and the entire cancer research and treatment community, in 2017, the Food and Drug Administration approved its first gene therapies – CAR T cell therapies Yescarta (for B cell lymphoma) and Kymriah (for refractory B cell acute lymphoblastic leukemia). City of Hope is one of the first authorized centers to provide Yescarta and Kymriah. CAR T cell therapy is one of the most promising areas of cancer research and treatment, and this approval is an important milestone, particularly for non-Hodgkin lymphoma patients.
Resources: To provide additional support to the research infrastructure, the Toni Stephenson Lymphoma Center recently launched a dedicated lymphoma tissue bank, and recruited a dedicated biostatistician and a dedicated project development scientist.
About the Stephensons
Featured Clinical Trials
Publication Highlights
Featured Grant Funding


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Jane's Addiction postpone Australian tour
Dave Navarro from Jane's Addiction announced on Twitter this morning that the band has been forced to postpone their Australian tour, to start tomorrow night, due to illness.
"Time to address the rumors. Our Australia tour has been cancelled. Stephen Perkins has injured his arm and is in the hospital being treated," said Navarro.
"He is going to make a full recovery and we are planning on making the dates up as soon as possible. We are extremely sorry to our fans in OZ."
"We were looking forward to bringing the band to you and PROMISE to return ASAP. Right now we are focused on supporting Stephen."
The band anticipates that this is only a postponement and that they will fulfill their tour plans as soon as they can.
Ticket holders for forthcoming gigs should hear from Ticketek today.
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History of Trinity
Careers at Trinity
From the Admission Team
Tuition Affordability
K-8 Advantage
Our Educational Philosophy
The Honor Code
Faith Studies
From the Chaplain Team
Celebrating Diversity | Events
Trinity Extended Day
Wildcat Summer Camp
Trinity Episcopal School is committed to the breadth of the Episcopal tradition in both its unity and diversity. We strive to create a welcoming environment to not only students and parents but to our faculty and staff.
A normal week at Trinity will begin with an exciting Monday morning at Greet the Week, and the week will end with an inspiring and uplifting community chapel on Friday. Between these days, there are many opportunities to engage with students outside of the classroom during our service learning, enrichments, tutoring, and coaching an athletic team.
Trinity Episcopal School is currently seeking Substitute Teachers. The ideal candidate must share a love for children, take initiative while being flexible, and commit to our three primary values of scholarship, diversity and spirituality.
Assignments are available in grades K-8 and can include self-contained classroom placements as well as enrichment classes such as music, faith studies, art, foreign languages, and physical education. Substitute teachers may be called with several days' notice of a planned TES teacher absence, the evening prior to or the morning of a TES teacher's unexpected absence.
Substitute teachers will receive lesson plans to guide their work in the classroom, and they will be supported by other members of the grade-level or department team. An ability to effectively teach and manage a group of twenty (20+) children independently is necessary. Substitute teachers should also have previous experience working with children in a daycare, camp or classroom setting. An undergraduate degree is required, and education majors or graduates are preferred.
Interested applicants should submit a resume, cover letter and application for employment to Gracie Ponjuan, gponjuan@tescharlotte.org.
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Trinity Extended Day (TED) Teacher
The Trinity Extended Day (TED) Teacher reports directly to the Director of Trinity Extended Day. We are looking for candidates interested in engaging in educational and recreational activities with children Monday through Friday, 2:30 to 6:00pm. Additional hours are available during in-service and partial school days as well as occasional evening events.
Teachers are responsible to:
develop and nurture connections with Extended Day students
supervise students in grades K-8 during recess
oversee homework
organize activities relative to specific age groups
communicate concerns to parents and/or Director of Extended Day
Report to and support the Director of Extended Day
The successful candidate will have the following qualifications and qualities:
A love for children and a willingness to go above and beyond in the best interests of students
Familiarity with and commitment to the mission of independent schools and Trinity Episcopal School, as well as the three primary values of scholarship, diversity and spirituality
Bachelor's degree with a focus on education or related field is preferred, but not required
Successful experience in working with children, preferably in a constructivist or progressive education environment
A willingness to go above and beyond in the best interests of students
Integrity, sound judgment, self-confidence, flexibility, maturity and a sense of perspective
Excellent interpersonal, organizational and communication skills, including basic technology competencies
Ability to be a self-starter and initiator, and ability to effectively work independently and be a contributing team member
A high level of energy and ability to work on many tasks/projects; a strong work ethic
Strong critical thinking, analytical, and problem-solving skills
Demonstrated sensitivity to students, faculty and staff of varying racial, ethnic, religious, gender, cultural, level of ability, sexual orientation and socioeconomic backgrounds
Trinity Episcopal School is committed to attracting and retaining outstanding employees through a compensation plan that compares favorably with those of other independent schools both locally and nationwide. Individual compensation is competitive and is determined by educational background and experience.
Please submit a completed application available on the website (tescharlotte.org), current resume and cover letter explaining your interest in and qualifications for this part-time position, which begins August 19, 2019 via email to Monica Johnson at mjohnson@tescharlotte.org.
Download Application for Employment
Submit cover letter, resume and application to Monica Johnson.
Tuition remission for for part-time and full-time employees
Medical, dental, long-term disability and life insurance plans
FLEX spending accounts
Walking distance to uptown CATS transportation center and lightrail system
Coaching opportunities
Paid stipends for extracurricular activities with students
Faculty and staff are supported in the pursuit of professional growth to improve student education and cultivate a community of lifelong learners.
Every year our employees complete over 2500 hours of professional development.
Graduate, certification or recertification work
Conferences and other professional experiences
Light the Fire Grant
The Light the Fire grant is professional development; however, it is above and beyond traditional professional development in its experiential approach focusing on the applicant's passion and interests.
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Title VII of the Civil Rights Act of 1964, as amended, prohibits discrimination in hiring, promotion, discharge, pay, fringe benefits, job training, classification, referral and other aspects of employment, on the basis of race, color, religion, sex or national origin.
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Trinity Episcopal School admits students of any race, color, religion, national and ethnic origin to all the rights, privileges, programs and activities generally accorded or made available to students at the School. It does not discriminate on the basis of race, color, religion, national and ethnic origin in administration of its education and admissions policies, scholarship and loan programs, and athletic and other school-administered programs.


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The First Trailer for Luc Besson's Valerian Is a Sci-Fi Fever Dream
Brian Raftery
Dane DeHaan and Cara Delevingne flirt—in space! (Also, hi Rihanna!)
M-4VDF-16373afrpsd Final (Left to right.)
Dane DeHaan, and Cara Delevingne star in EuropaCorp's Valerian and the City of a Thousand Planets.
Photo credit: Vikram Gounassegarin
© 2016 VALERIAN SAS Ð TF1 FILMS PRODUCTION
It's been almost 20 years since the release of The Fifth Element, writer-director Luc Besson's delightfully garish, unapologetically maximalist space-jam—and the film that proved that, in space, everyone can hear Chris Tucker scream. Next year, Besson returns to big, noisy sci-fi with Valerian and the City of a Thousand Planets, the first trailer for which you can watch above.
Based on the long-running French comic book series Valérian and Laureline, the movie stars Chronicle's Dane DeHaan and Suicide Squad's Cara Delevingne as galactic operatives with a complicated relationship ("We get on just great—you flirt, I smile," Delevingne says at one point, before delivering a brutal sucker-punch). And because this is a Besson flick, we also get all kinds of oooh-inducing visuals, from neon-glazed cityscapes, to gorgeously gargantuan aliens, to Rihanna getting all Fosse-fied in a Sally Bowles-inspired get-up.
Will any of this make sense? Who knows! But we'll be ready to get our Bess-on when Valerian opens in July.
TopicsMoviestrailersValerian


Robert Adamson is currently single.
Robert Adamson has been in relationships with Linsey Godfrey (2012) and Erica Hubbard (2011).
Robert Adamson has had an encounter with Laetitia Casta (2006 - 2011).
Robert Adamson is a 33 year old American Actor. Born Robert Gillespie Adamson IV on 11th July, 1985 in Salt Lake City, Utah, USA, he is famous for Lincoln Heights,The Young and the Restless. His zodiac sign is Cancer.
Robert Adamson has been in 6 on-screen matchups, including Caitlin Elizabeth Baunoch in The Young and the Restless (1973), Jamie Chung in Princess Protection Program (2009), Kelli Goss in The Young and the Restless (1973), Sofia Pernas in The Young and the Restless (1973) and Tiffany Thornton in Sonny with a Chance: Sonny's Big Break, Volume 1 (2009).
Robert Adamson is a member of the following lists: People from Salt Lake City, American male soap opera actors and 21st-century American male actors.
Help us build our profile of Robert Adamson! Login to add information, pictures and relationships, join in discussions and get credit for your contributions.
Robert Gillespie Adamson IV (born July 11, 1985) is an American actor. He has portrayed the roles of Phil Sanders on the television series Hollywood Heights and Charles Antoni on Lincoln Heights. He currently stars as Noah Newman on The Young and the Restless.
Linsey Godfrey and Robert Adamson dated in 2012.
Robert Adamson and Erica Hubbard dated in 2011.
Robert Adamson and Laetitia Casta had an encounter in 2006.
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Hey, Robert. It`s me again. Can someone help find a boyfriend?!
Hey, Robert. You are sooo cute! I love you!!! Krystal, your name is not similiar to my best friend`s name. Her name is Crystalyn Downey. I hope you and I can be best friends.
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Connect any celebrity with Robert Adamson to see how closely they are linked... romantically!


In order for you to be able to enjoy your natural power and true beauty, we created Bio2You, which combines the healing energy of nature with the wisdom of science.
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It turned out that the sea buckthorn is phenomenal and there is nothing similar to it in the whole world! Can you believe that it consists of more than 190 bioactive components, including many antioxidants, 18 amino acids, 14 vitamins (A, all B group, C, D, K, P), provitamins, and 4 omegas (omega 3 - decreases inflammations and takes away the tiredness, strengthens the heart; omega 6 - decreases the risk of malignant tumours; omega 7 - decreases the joint pain, eczemas and symptoms of psoriasis; omega 9 - decreases the cholesterol level)? Vitamins in the sea buckthorn are in larger concentration than in any other plant, for example vitamin A is three times more than in carrots, vitamin C - 10 times more than in oranges and vitamin E 4 times more than in the sunflower seeds. This rich composition suits to almost any ailments and has deserved to be called YOUTH ELIXIR because it renews cells, regenerates, prevents illnesses induced by age; it is an incredible energy restorer and even decreases the risk of malignant tumours. It is unclear why we know so little about it!
We created 100% natural sea buckthorn juice with small additive of apple juice to improve the taste - we were surprised how delicious this juice was!
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For thousands of years I have been sprouting in soil; I grow strong and create wonderful berries. Not without a reason a healer in China, Tibet and Greece already thousands of years ago appraised my powers by using the berries in treatment of skin and internal diseases, as well as the sedative and healing effect of my oils in cases of inflammations.
For some periods I was undeservedly forgotten however I got discovered again and again anew, and with each time my powers were used more and more widely. All of my more than 190 bioactive substances - countless antioxidants, 18 amino acids, 14 vitamins, provitamins, microelements, and unsaturated fatty acids - are yours! I'll make you happy with my incredibly concentrated vitamins that I have more than other your admirers. I'm one of the rare herbs whose leaves and berries contain practically all vitamins being in the nature because my berries have both juice with water-soluble vitamins and oil with vitamins soluble only in oil. I take care that in the base of your beauty were health given by the nature because I'm to improve immunity, renew cells, delay aging, give a boost of energy and decrease the risk to become ill. I'm only valuable. I don't contain alcohol, dyestuff, or products of animal origin.
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The National Chief of the Assembly of First Nations (AFN) holds out hope the Pope will come to Canada to apologize for Indian Residential schools, despite news Pope Francis has decided not to.
AFN National Chief Perry Bellegarde said he will ask for a face to face meeting with Pope Francis so he can impress upon him the importance of this apology to bring about healing and reconciliation. He will also ask the pope to renounce the Doctrines of Discovery and terra nullius that were used to justify the colonization of Indigenous lands.
"He's a very special man, and for him to show that strong leadership on those two requests, I think would be a strong act of healing and strong act of reconciliation going forward," he said.
"I will continue to urge Pope Francis to come to our homelands as per TRC Call to Action #58 to meet with the peoples, with survivors and their children of the residential school system, because that in itself would be an act of healing," he said.
News of Pope Francis decision came in a Mar. 27 letter to the Indigenous Peoples of Canada from the president of the Canadian Conference of Catholic Bishops (CCCB), Bishop Lionel Gendron. It stressed the bishops' commitment to reconciliation and the Pope's encouragement that the bishops continue reaching out in "intensive pastoral work" to further healing and working to improve the conditions of First Nations peoples.
Archbishop Richard Gagnon of Winnipeg said the Pope has been involved in "considerable dialogue over the last number of months," concerning the TRC.
Archbishop Gagnon noted that the Pope is not ruling out a visit in the future.
"He has said he is open to coming to Canada and top on his priorities would be a meeting with Indigenous people," he said, noting this was one of the main priorities of St. John Paul II's visits to Canada.
Bellegarde noted the Pope apologized in Bolivia to Indigenous people there and in 2010 Pope Benedict XVI apologized to the Irish people for sexual abuse by priests.
While Pope Benedict XVI had also expressed sorrow to the former AFN National Chief Phil Fontaine and other First Nations leaders and residential school survivors at a meeting in the Vatican in 2009, Bellegarde said he hopes Pope Francis will build on what Pope Benedict did by apologizing in Canada.
Though he's aware there is some positive growth in some parts of the country in relationship-building between Indigenous communities and the church, in his area of Saskatchewan, the opposite is happening.
"The young people are not interested in any serious way to engage with the Catholic Church," he said.
Lafond thinks the Pope's apology and presence on Canadian soil is needed to make those efforts mutual.
"I believe the door is still open," said Deacon Rennie Nahanee, a Squamish elder who works in the Vancouver archdiocese's Office of Ministries and Outreach.
In the meantime, Nahanee said he looks forward to seeing Indigenous peoples "talking to the bishops, telling them about their reality.
There had been reports of some division among bishops on whether to invite the Pope, with Bishop Gendron raising concern last year about possible law suits at a result of a papal apology and others worried about the cost of a such a visit.
"A papal trip is a complex thing, a lot of different levels are involved but the cost issue may be of some concern for some but that was not a focus of conversation, not in my experience anyways," Archbishop Gagnon said.
There was also disappointment expressed in Ottawa.
The CCCB president Bishop Gendron and Cardinal Gerald Cyprien Lacroix of Quebec met privately in Ottawa with Justin Trudeau in Ottawa on Mar. 26 to give him advance notice of the Pope's decision.
"When the president met with the Prime Minister and Cardinal Lacroix, there was a number of Church concerns were that were raised, and summer jobs was an important aspect of that, but do I see any relationship between the two? No," he said.
"The Prime Minister himself was in Rome some time ago and spoke to the Holy Father, so it was appropriate to have that connection made," Gagnon said.
Trudeau had not only personally invited Pope Francis to Canada, he promised to fulfill all 94 of the TRCs Calls to Action, including the papal apology.
"I think that what we're hearing from survivors and, and Catholics is that they, they want to continue to pressure and hope that they will change their mind and understand how important it is to be survivors here in Canada for him to do this here in Canada.
Bennett said Pope Benedict's expressions of sorrow for the Indian Residential Schools made in 2009 to Indigenous leaders and residential school survivors was not enough.
She said the government will continue to support survivors and for the apology they have said is important for their healing.
"I know that the survivors and the Catholics that have approached us are going to continue to ask and to press, put pressure in their diocese, to their priests and to, to whoever will listen that, that this is really important to them," she said.
I hope that the Grandin media will not become a indigenous paper like the Western Catholic had become . It is time they took some of their responsibilities and that some of the real truth and issues were dealt with. All the media they get is unnecessary . I would have as many horror stories as them only for being french.. But no one wants to take up our cause as there is no money in it. Enough is enough . An apology from the Pope what a farce… Pope John Paul 11 did it x 2 . We all know money is behind all this .. and us of the working class are running out… I could go on and on with all the lies that have been told …no one would believe me as I don't have any money or political power.


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A Big Year for MBD: Key Takeaways from SOLIDWORKS World 2019
I recently returned from my last SOLIDWORKS World in Dallas, Texas. I say last because starting next year, what has been known as SOLIDWORKS World will be known as 3DEXPERIENCE World, a renaming prompted by parent company, Dassault Systemes.
This year's event was interesting, not just because of the rebranding, but for the attention paid to Model-Based Definition (MBD) and the Model-Based Enterprise (MBE). Both initiatives have been championed by Action Engineering for several years as major evolving trends for contemporary and future product design and manufacturing.
As an industry observer and participant, I think that SOLIDWORKS is following the path of PTC with their MBD rollout, but they're not evolving their MBD solution as rapidly as I and many SOLIDWORKS customers would like. I see them backing away from it to see how it goes at this initial adoption phase for SOLIDWORKS, and then pushing it to the next level.
Although SOLIDWORKS is a bit behind PTC's Creo regarding MBD, I think they're going to pick up the pace. I think this is just an evolution, a journey that not only will the customers be on, but the CAD companies, as well.
SOLIDWORKS World 2019 offered a lot of presentations and classes surrounding MBD, ranging from very basic to advanced, which is a good sign. It's especially interesting because we're definitely moving from early adoption phase into a surge of adoption occurring across the board, including a lot of SOLIDWORKS customers. I think it is good news and a sign people are buying into model-based definition, and the fact that they know that the 3D information can be used in machine readable ways. I am seeing a balance of machine-readable data versus presentation for human consumption information and how that is balanced as we proceed down the path to the model-based enterprise.
So far I've discussed what's out right now in SOLIDWORKS 2019. Looking ahead to the fall when SOLIDWORKS 2020 comes out, I'll address some new features and capabilities that I'm hoping we might see.
Specifically, from the model-based definition side, we might see enhanced usability for applying PMI, or applying annotations. That's a big deal because of what we've experienced when we train users is the fact that they can't yet show and hide an individual annotation on an individual 3D View. That would really be a great enhancement. I'd also like to see this available on any 3D View you choose.
Ideally, you want to be able to pick and choose any annotation and show/hide it in any 3D View. We've worked with this capability in Creo, NX, and Inventor where you can pick and choose the annotation onto any view rather than collect them only on an annotation view. That would be a big usability game changer for SOLIDWORKS.
In the next release of SOLIDWORKS it would be helpful to see tolerances that could be both machine readable as well as human readable. There are still a few SOLIDWORKS DimXpert annotations that lack both.
This possibility can be addressed from the SOLIDWORKS DimXpert side and the user side – the authoring side and the consuming side. DimXpert has a really great machine-readable capacity and has a pretty decent human readable capacity with the exception of the 3D View show/hide authoring issue. There are also a handful of usability issues I think that could be addressed in SOLIDWORKS from the human readable perspective that would enhance things, such as:
Evolving mapping of metadata during 3D PDF publishing to be repeatable. I discovered a few quirks. Not show-stoppers, but annoyances.
Machine readable datum targets. These are super critical for those who manufacture parts that are casted, forged, 3D printed, or have wonky geometry.
Did I mention hiding / showing individual annotations in any 3D Views as an ad-hoc capability, rather than grouped by annotation plane?
Additional machine readability can be leveraged through QIF, and if I pull in Origin International, they actually have a SOLIDWORKS implementation that performs automated CMM programming.
I think there is a huge use case, especially from NX to SOLIDWORKS for OEM to supply chain usability that is really important. From a machine-readable perspective, it's there. Third-party vendor interoperability requirements are needed. It would be great if all standard parts had the unique machine-readable information and tolerances that could aid tolerance stack-up analysis. This is where we're really starting to get to the holy grail of model-based definition, where ROI will be revealed.
This machine/human readability issue affects us and our customers, because it supports Action Engineering's "reuse your CAD" philosophy, which is the delivery of a low- and a high-fidelity model at the part detail level.
High-fidelity models take up a lot of file space, so I appreciate that vendors, such as CADENAS PARTsolutions, have part model libraries with low, medium, and high levels of detail. There's a lot of thought that's gone into those levels of detail so that you can maximize the performance of your assembly as you tree it up into the part, but still maintain that visual component of presentation or human readability.
Low fidelity models, also known as lightweight can be displayed faster with higher performance levels, while protecting IP.
eDrawings has been one of the more popular aspects of SOLIDWORKS for years, and I think for the 2020 release of SOLIDWORKS, DS will enhance it for greater MBD usability.
I especially like eDrawings for in-house manufacturing. There's a lot of capability and functionality that can be maintained from the native SOLIDWORKS model onto the shop floor. We recently worked with a company that does weldments. Weld beads in SOLIDWORKS assemblies do not translate out into a 3D PDF, but they do translate out into an eDrawing. If you're designing and manufacturing in house, just keep it all in that one tool suite. I think that's a great functionality for 3D work instructions, especially welding if SOLIDWORKS is your tool.
So, how could the direction of MBD with SOLIDWORKS affect our business and customers?
The adoption of MBD within SOLIDWORKS is growing but is in for a bit of a rough road with the MBD product managers at SOLIDWORKS, at least for a while. On the other hand, MBD is a natural evolution of things that really resonates with Action Engineering since we're in the business of awareness, training, and support for bringing people up to speed on the details and implementation of MBD.
All MBD tools are ground-breaking and game changers for companies who figure out how to use them effectively. My best wishes to the SOLIDWORKS MBD team in the upcoming evolutionary journey they are embarking on.
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Jennifer Herron
Jennifer Herron is the CEO of Action Engineering, a registered Women-Owned Small Business that specializes in guiding organizations through their transformation into a Model-Based Enterprise (MBE) using Model-Based Definition (MBD). She serves on the Board of Directors of the Digital Metrology Standards Consortium (DMSC) which maintains the QIF and DMIS standards. Ms. Herron has extensive experience with hardware design for spaceflight and military systems, and as such, is an expert in multiple CAD packages (e.g. Creo, NX, SOLIDWORKS, Inventor). She holds a patent for a snake propulsion mechanism and is the author of Re-Use Your CAD: The Model-Based CAD Handbook. Because standards are the lynchpin to a digital transformation, she also serves on the American Society of Mechanical Engineers (ASME) as chair of the ASME Y14.46 Subcommittee on Product Definition for Additive Manufacturing (AM), ASME Y14.47 Digital Product Definition Data: Model Organization Schema Practices, ASME Y14.37 Composite Part Drawings, and the newly formed ASME MBE Steering Committee.
Latest posts by Jennifer Herron (see all)
Democratizing MBE: Key Takeaways from the MBE Summit 2019 - May 13, 2019
A Big Year for MBD: Key Takeaways from SOLIDWORKS World 2019 - March 20, 2019
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Preparing graduates for the workplace
09 March 2020 | Story Prof Francis Petersen | Photo Sonia Small
Professor Francis Petersen is the Rector and Vice-Chancellor of the University of the Free State
The shortage of skills is a global phenomenon and employers are concerned about the need for skilled professionals to meet the demands of various sectors of their economies. This situation has reached worrying proportions in South Africa, where it has become apparent that there is a nonalignment between the skills graduates are equipped with and those that are required in the workforce.
Moreover, the continuous contraction of the South African economy is further spurring the unemployment crisis: the weak economic performance is not sufficient to create jobs in line with the growth of the working-age population. It is also evident that skills shortages and a lack of social capital have become a systemic problem that prevents access to jobs.
Preparing graduates for the world of work
Unemployment in South Africa is about 29%, according to Statistics South Africa's latest Quarterly Labour Force Survey; the unemployment rate of people between the ages of 15 and 34 years is 56%. Earlier this month, President Cyril Ramaphosa announced in his State of the Nation address that the country is facing its highest unemployment rate since 2008. Referring to youth unemployment as a "crisis", the president said about two-thirds of the 1.2-million young people entering the labour market each year remain outside employment, education, or training.
There is an argument that a university graduate should not necessarily be job-ready, but must have the ability to think, to adapt and to learn relatively quickly. Even with this expectation, it is critically important to understand the world of work and to have a relationship with the job market. This is not only important from a future employment perspective, but it will also bring the job market closer to the academic curriculum and the research agenda of the university. It goes a long way towards starting to co-create solutions and conceptualising futures that are more inclusive and sustainable.
UFS interventions to improve student success
The University of the Free State (UFS) has taken collaboration with the private sector, industry, and commerce very seriously — most of the academic departments have industrial or sector-specific advisory boards through which robust discussions are taking place concerning the curriculum, appropriate funding to students, interventions to improve student success, challenges of the job market, and which research projects are essential to tackle. Through these boards, a relationship between the university, industry, the private sector, and commerce is established. This is a good starting point not only to address employment, but also to provide a catalyst for optimising an ecosystem to address the country's economic challenges.
UFS has also established a Short Learning Programmes office, as we believe that training and retraining workers in an ever-changing job market is essential.
Our proactiveness in creating platforms of engagement with companies about student recruitment — as well as motivating companies, donors, and funders to employ and fund our top graduates — is evident through the work of our Career Services office. Trends in job placement are identified to help us better understand which markets to tailor our programmes to, and to create corporate partnerships for job-training opportunities. Keeping our students informed about career opportunities and equipping them with the skills and grit to make them employable — whether it is to find employment or to start their own business, is the Career Services' goal.
Developing an entrepreneurial mindset
Entrepreneurship has a vital role in combating unemployment. Equipping students with an entrepreneurial mindset is a priority, and "entrepreneurial thinking" is one of the university's key graduate attributes.
UFS supports the notion that preparing young jobseekers for the ever-evolving world of work is an integral aspect of their learning at university. We offer a compulsory foundation module to expose all of our first-year students to aspects of entrepreneurship, which are also captured throughout the curriculum.
The UFS Business School has developed initiatives and training programmes specifically aimed at entrepreneurial enterprises. Our Centre for Business Dynamics works with the business sector, helping companies to stay competitive by bridging the gap between existing skills and those required by each industry. Short courses in entrepreneurship are among the tools they use to achieve this. Practical impetus is provided to students with business ideas through our Student Business Incubator; initiatives such as Young Entrepreneurs and the local chapter of Google's Startup Grind U further stimulate entrepreneurial thinking.
Solving the skills gap
At UFS, we have found that to help the country in solving the skills gap and allow higher education institutions to thrive, various factors, such as industry, region, and job role are important. It has become all too clear that it is not enough to have only technical knowledge — a combination of skills is required for most jobs as technology becomes an integral part of daily tasks in the workplace. Education efforts should focus on areas that set individuals apart from machines and technology.
There is a need for graduates to evolve with career opportunities, as many employers consider critical and strategic thinking skills as fundamental in middle-management roles. Collaboration, negotiation, emotional intelligence, cognitive flexibility, and resilience are important abilities in the workplace.
With the right skills and networks, our graduates will be able to secure employment, have enterprising mindsets to support and sustain themselves, and contribute to the development of their communities.
A strong focus on employability as part of the core business of a university and the ability to equip our graduates with the necessary skills will remain crucial factors in the years to come. Our relationship with industry, the private sector, and commerce is crucial to driving this.
This article was published in the Mail&Guardian newspaper on 6 March 2020
2012-06-29 Seminar puts language issues under spotlight
2012-06-28 Over 300 diplomas in Financial Planning Law awarded
2012-06-27 UFS visits Namibian schools
2012-06-22 Theology Faculty boosts NSH campaign
2012-06-18 Deborah Meier on Education and Social Justice
2012-06-18 UFS Winter Graduation Ceremony
2012-06-15 Transformers in Action
2012-06-13 Another Architecture student scoops prestigious prize
2012-06-08 DB Prinsloo now Director of KovsieSport
2012-06-07 DF Malherbe Memorial Lecture reflects on the role of Afrikaans
2012-06-07 Strategic Plan for 2012-2016 launched
2012-06-07 SRC visits the US as part of Global Leadership Preparation Programme
2012-06-07 Increasing safety measures
2012-06-06 Postgraduate success rewarded during winter graduation ceremony
2012-06-06 International scholar talks about the right to food in South Africa
2012-06-06 New wheels for students with disabilities
2012-06-01 Draft Defence Review Policy discussed


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Q: Swift mongoc.h file not found I am trying to install the Mongo Swift library using cocoapods but am fronting some problems.
As the documentation pointed out, for the mongo swift pod to work, it needs the mongo-c-driver. Which I installed using homebrew and is sitting in the Cellar folder in my usr folder(Meaning it is installed). I then modified the podfile the same as the example and when running pod install the library is correctly installed.
The problem then comes when i open the project and try to build it. I have now these two errors:

'mongoc.h' file not found
Could not build Objective-C module 'libmongoc'

I made sure that I open the xcworkspace and not the default workspace.
I also tried to add the path to the mongoc.h file to the Runpath Search Path in hope of some results but without luck.
As you may see i do not understand a lot of this and it basically could be something silly. But I do not know how to get this library to work.

A: So i managed to get it to work.
I don't know why this happened but the header and library search paths were set wrongfully. I had installed version 1.10 of the mongo-c-driver and the search version in xCode was set to 1.94.
I also was trying to modify the search paths in my own project rather in the cocoa project which led to absolutely no results.
TLDR; Add the correct include and lib folder to the Header/Library Search Path in Xcode and make sure you set it in the Pods Project.

redpajama_set_name: RedPajamaStackExchange


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P Press Releases
Kumano Region Named Japan's No. 1 Travel Destination for 2020
Japan's spectacular "land of the gods" in Wakayama Prefecture claims the top tourism award in GaijinPot website's reader poll. TOKYO — The ancient Kumano region — known as the "land of the gods" — topped the list …
GaijinPot Releases Nominees for Japan's Top Travel Destinations in 2020
Tokyo-based website publishes annual short list of best places to visit in Japan and asks readers to help with the final decision. TOKYO — GaijinPot Travel has released its list of nominees of best travel destinat…
New User Interface for GaijinPot Jobs
If September has you dreaming about autumn foliage, the changing of the leaves and personal resolutions (like putting all those hacks and tips for a mobile-first life into practice as you get back in the flow), then now …
Showcase your company at the "Welcome to Japan Forum"
TOKYO — On Nov. 16 at Cirq Event Hall in Shinjuku, over 500 English-speaking job seekers will gather for the annual GaijinPot Job Fair. This year, along with a larger venue, there is an added "Welcome to Japan Forum" — c…
Tottori Prefecture Named Japan's No. 1 Travel Destination for 2019
Tottori's adventure tourism a driving force for the honor by a Tokyo-based travel media. Japan-based English-language travel website GaijinPot Travel released its lineup of the best places to travel to in Japan in 2019. …
Coming Soon in May! Australia & New Zealand Online Job Fair 2018
The CareerEngine Network is proud to announce the Australia & New Zealand Chamber of Commerce Japan Online Job Fair 2018. The Online Job fair will be held commencing the month of May 2018 to the end of June 2018 to a…
GPlus Media acquires Vision Consulting Services K.K.
GPlus Media Co Ltd, a pioneer media company targeting the international community in Japan and abroad and a member of Fuji Media Holdings Inc (FMH), announced Friday the acquisition of Vision Consulting Services KK, a re…
GPlus Media acquired by Fuji Media Holdings group company
Fuji TV-Lab, LLC (President & CEO: Tadashi Tokizawa, Fuji TV-Lab), a subsidiary of Fuji Media Holdings, Inc. (President & COO: Hideaki Ota, FMH), has announced the acquisition of GPlus Media Co., Ltd. (GPM).