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Following a rock/metal album recorded with his band ORBI [BIS-2297], Bram van Sambeek returns with his own idea of a dance album. For it he has selected four works by Johann Sebastian Bach that consist mainly of typical baroque dances - but just as van Sambeek's metal album wasn't made for headbanging, Bach's dances weren't meant for dancing, but rather to be listened to. The album opens with van Sambeek's own arrangement of the celebrated Partita in C minor for keyboard which he describes in his liner notes as one of his favorite works to listen to. The arrangement includes every note of the original keyboard part and is for no less than eight bassoons - all played by van Sambeek using multitrack recording technique. The idea for this came from having spent months in lockdown due to the pandemic: even though musicians were unable to play together, the urge to play actual harmonies persisted. Four movements from another keyboard work - the French Suite No. 5 - are also included on the disc, but as these are melodic rather than contrapuntal they have lent themselves to be arranged for a single voice. The remaining two works are the Flute Partita in A minor and Cello Suite No. 1, adding to an overall result which allows a new look on well-known works, with new nuances and colors.
Label: BIS
Bach On The Bassoon (Hybr)
Artist: J Bach .S. / Sambeek

redpajama_set_name: RedPajamaCommonCrawl


text:
HU Близнецов () — двойная затменная переменная звезда типа Алголя (EA) в созвездии Близнецов на расстоянии (вычисленном из значения параллакса) приблизительно 20 347 световых лет (около 6 238 парсек) от Солнца. Видимая звёздная величина звезды — от +16,6m до +15,7m. Орбитальный период — около 1,7003 суток. Возраст звезды оценивается в среднем как около 760 млн лет.

Характеристики
Первый компонент — бело-голубая звезда спектрального класса B8. Масса — около 1,92 солнечной, радиус — около 2,11 солнечных. Эффективная температура — около 9448 К.

Второй компонент — белая звезда спектрального класса A9.

Примечания

redpajama_set_name: RedPajamaWikipedia


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NCCPR news and commentary round-up, week ending December 21, 2021
December is the month when editors rush to publish big projects, so they'll be eligible for awards competitions. That helps explain why there's so much this week – though probably not the first item:
● As we prepare for another surge in COVID cases, this seems a good time for a reminder of the massive amount of media malpractice that took place at the start of the pandemic, when almost every news organization in America accepted the myth that, in the absence of overwhelmingly middle class, disproportionately white "eyes" constantly on overwhelmingly poor disproportionately nonwhite kids, their parents would unleash upon them a "pandemic of child abuse."
The latest to debunk this myth is the ultimate medical and child welfare establishment source: JAMA Pediatrics. Unfortunately, it's one of those overpriced journal articles – but every reporter who bought into, and spread, the myth, has an obligation to pay up and read it. The title explains it all: "Child Physical Abuse Did Not Increase During the Pandemic."
● A handful of news organizations already had figured that out; but they were drowned out by those which, even in the midst of a racial justice reckoning, bought into a "master narrative" that is racist at its core. Still more evidence that there was no pandemic can be found in a landmark study from New York City by Prof. Anna Arons of New York University School of Law. She recently discussed her findings. There's video and a summary on this blog.
● As we learn more about the horrors inflicted on Native American children in "boarding schools" it's tempting to dismiss that as mere history. That will be a lot harder if you read this story from The Fuller Project and Mother Jones about the horrors family policing is inflicting on children right now. From the story:
"For the families that we work with, it's constantly living in a state of fear," says [Teresa Nord of the Indian Child Welfare Act Law Center]. "Grandma was in the system and now Mom is in the system and now the child is in the system… How can we expect our community members to even start healing? … "I live with this constant fear," says Nord. "I call it child protection PTSD, that they're just gonna one day knock on my door."
The story zeroes in on the state with the worst record in the country – right now – for tearing apart Native families: Minnesota. As one expert put it:
"There's such a weird disconnect in Minnesota between this progressive rhetoric and this really racist structural system. We've seen that with police brutality in Minnesota, but it's also true in the child welfare system."
Although Minnesota is worst, it's far from alone. For some context, consider revisiting the outstanding NPR stories from 2011 on these same issues in South Dakota.
The next three stories have a common thread: If you do not conform to the child welfare establishment's straight, white, middle-class version of exactly what a parent should be and how children should be raised, then the family police are gunning for you.
● A mother tries to support her child as he explores his gender identity – just as experts suggest. She raises her children with love and care even though she is herself a victim of domestic violence. Then an anonymous caller turns her in to the family police. Roxanna Asgarian tells the story of what happened to the children in New York Magazine. I have a blog post about some of the key takeaways.
● Remember the Pennsylvania judge who took away a father's children because he deemed the father too obese? The York Daily Record has an excellent story about that case.
● And in New Jersey, NJ.com takes an in-depth look at racial and class bias in the New Jersey family policing system. (Though it's billed as a subscriber exclusive, if you give them your email address, they'll let you read it for free.)
● At least the children in the stories above are still alive. Tragically, things turned out differently in a case in Tennessee. As the Tennessee Tribune reports, the state's family policing agency
forced itself into [the mother's] home to "rescue" two toddlers and a ten-year-old who didn't need their help at all. They suffered months of trauma; the youngest child died.
In this case the hospital involved got it right – but it didn't matter, the family police took the child anyway. In another case, also reported by the Tennessee Tribune, the same hospital got it terribly wrong.
● It's a Christmas miracle! After years of ignoring, and sometimes fomenting, foster-care panic, even the Tampa Bay Times admits a lot of children are being needlessly torn from everyone they know and love in that part of Florida.
● Alas, no ghosts have visited the journalists at the Miami Herald yet. I have a new column in Florida Today on what the foster-care panic started by the Herald (and encouraged by the Times, at least until now) has done to children in that state.
● How far there remains to go can be seen in the fact that, as The Imprint reports, a bill that simply would require the New York City family police agency to tell families their rights did not get a vote in the City Council – in large part because the family police in New York City don't want families to know their rights. But, of course, if you don't know your rights, you don't have those rights – which is how the family police want it.
● Shortly before giving birth, one mother ate a poppyseed bagel; another a salad with poppyseed dressing. A hospital in Upstate New York drug tested them without their consent – and turned them in to the family police, which conducted traumatic investigations. Now, WTEN-TV reports, both mothers are suing, with the help of National Advocates for Pregnant Women and the New York Civil Liberties Union. According to the story:
"By drug testing me without my consent and reporting a false presumptive positive result to child welfare authorities," one mother said, the hospital "turned what should have been the most meaningful moment of my life into the most traumatic one. …they treated me like an unfit mother, told me I wasn't allowed to breastfeed, repeatedly denied my requests for a confirmatory test, and ensured my name would be on the [state central registry of alleged child abusers]."
● These kinds of policies are fueled whenever the hype and hysteria over drug use meets the hype and hysteria over child abuse. Though not touching directly on child welfare, this column by Jay Caspian Kang in The New York Times illustrates, once again, how desperate we are to find another Worst Drug Plague Ever so we can keep on blaming poverty on poor people.
● Remember those excellent NPR/Marshall Project stories about how family policing agencies grab foster children's social security benefits to fund their agencies? No one should be surprised that Philadelphia is among the prime offenders. And now the Philadelphia Inquirer reports on how they do it, and what it does to families.
Our annual holiday reminder
It's a Christmas miracle! Tampa Bay Times discove...
NCCPR news and commentary round-up, week ending De...
Child welfare lessons from New York City's "uninte...
Lesson from an appalling case in Michigan: If you ...
NCCPR in Florida Today on what the Miami Herald's ...
UPDATED: A Pennsylvania case illustrates again why...
NCCPR news and commentary round-up, week ending No...


The winner of season 12, Darci Lynne, is back with an amazing rendition of "Show Off." What did you think? Please leave a comment in the section below and remember to share the video and sign up for our free newsletter!
I saw her when she was competing on A.G.T. and she was my choice to win that year right from her first performance. She's the most talented ventriloquist I've ever seen. So young and so talented.
I agree with Janet. She is THE most accomplished ventriloquist I have ever seen…at 14 years old, yet.
"They" are so fabulous! So perfect in original presentation….
I thought she has really become a professional, and has had great opportunities to work with the best! All the best of luck to this young lady! What a career she has ahead of her!
Awesome talent. Will set show business on fire. Fantastic control of her voice.
What a remarkable young lady!!!! She has talent, stage personality, is gracious, and indeed a superb ventroliquist. My hope iss that she goes far in the entertainment field. We need more wholesome talent like thisn for the youngsters growing up in today's frightful world.
Congratulations Darcey Lynn, you are undeed a WINNER!!!!!


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Q: Selecting the Correct Display Item Field when Adjusting Fonts in SSMS 2017 I am trying to use adjust the font color in SSMS 2017 and
it's hard to find which Display Items certain symbols fall under.
1)  Where do T-SQL commas fall under?
2)  How can I find out?  Is there a list somewhere?

A: Commas come under 'SQL Operator', but apply also to parenthesis (), asterisk * and periods . (and likely more including but not limited to !, %, ^)

redpajama_set_name: RedPajamaStackExchange


Tom Rogić was missing due to injury while Jackson Irvine was not in the squad.
Cameron Burgess played a full match, Ryan Williams came on in the 85th minute and Adam Taggart was missing due to injury.
Bradden Inman started and scored twice (1-0, 6′ + 2-2, 77′).
Adam Griffiths played a full match for Kedah while Mario Karlović also played a full match for Terengganu and scored (2-3, 74′).
Goran Šubara (no detailed info available).
Trent McClenahan did not play, Michael Beauchamp played a full match and scored (2-2, 77′) while Matthew Thompson did not play.


Rich and rhythmic, sparkling and seductive, Felix Baloy's voice marks him as one of Cuba's very finest soneros. These ten magnificent performances showcase a true artist at the peak of his profession, backed by the thrilling arrangements of Juan de Marcos and the peerless Afro Cuban All Stars.
Felix Baloy has been singing for more than 40 years which means he has waited a long time to make his first solo album. One of Cuba's outstanding soneros with a unique timbre, the opportunity came about after he met Tumi Music founder Mo Fini in Havana in 1995 when Baloy sang on the label's splendid four CD set Las Leyendas de la Musica Cubana as part of the Cuban All Stars with Orquesta AmÈrica. Other singers on the project included Celina Gonz·lez and Omara Portuondo.
Felix Baloy Valdez Sautiz was born on November 20, 1944 in MayarÌ in eastern Cuba. His family was poor but his grandmother lived close to the legendary Ali Bar in Havana, where the great Beny MorÈ was a regular performer. To jump the fence every night and listen to some of Cuba's greatest performers was an unrivalled musical education for a young boy.
What he heard rubbed off and eventually a friendly uncle recognised the boy's talent and recommended him to a local band leader. By the late fifties he was singing with the group Mi Amparo. But when the American tourists departed following the revolution, there was little work for professional musicians and lean years followed in which Baloy worked on the railways and as a milkman and a shoe repairer. By the mid seventies, cultural isolation had left Cuban music at a low creative ebb. Yet paradoxically it was to prove the turning point in Baloy's career. Soon he was making a dramatic impression singing with Elio RevÈ's group. A band leader with an eye for new talent, RevÈ had a decade earlier discovered Juan Formell, who went on to lead the great Los Van Van and Juan Carlos Alfonso, two figures who helped transform the face of modern Cuban music.
Baloy stayed with RevÈ only a short time for his reputation as one of Cuba's most exciting soneros was growing fast. Before long he had joined Tropicuba, where he sang alongside Ra™l Planas, destined to be a colleague again almost 20 years later in the Afro-Cuban All Stars. But soon he was off again, this time to Santiago de Cuba to sing with Son 14 under musical director Adalberto Alvarez.
By now Baloy was one of Cuba's most in-demand soneros and he was tempted back to rejoin Elio RevÈ y su Charangon, this time as lead singer. By 1983 he had been reunited with Alvarez as the singer with his new orchestra, which swiftly became one of Cuba's leading salsa ensembles. He was to stay almost a decade. In the nineties Baloy became a resident singer at the Ali Bar, an emotional return to the venue where he had first heard Beny MorÈ as a boy. Then when Juan de Marcos Gonz·lez put together the Afro-Cuban All Stars in 1996 with the intention of recapturing the glory of the big band years, Baloy was one of the first names on his list. Juan de Marcos was an obvious choice as producer when it came to recording Baloy's first solo album.
Felix Baloy has been the main vocalist of the group Afro-Cuban All Stars and one of the Buena Vista social Club singers. Known as the sonero of the soneros , this compilations offers some two decades of Baloy recordings with both his band and Juan de Marcos Gonzalez band Afro-Cuban All Stars.


LA REALIDAD, Chiapas, April 29, 2004. It's two in the morning on Thursday, April 29. Unable to sleep, we can see, illuminated by a distant lantern, the shining eyes of a person whose face is covered by a ski mask. "Don't worry, comrade," says the face behind the mask, observing our restlessness, "they're just having a meeting." We try to get to sleep. Around three, we hear voices, mostly women. "Rest, friend, they're just doing some organizing," says someone else, as we hear horses galloping far away.
Such nights are typical for the insurgents of the Zapatista Army of National Liberation (EZLN in its Spanish initials) in the Lacandon jungle. They work mysteriously during the day, and also at night. They act with amazing caution, and in silence. Their wisdom comes from their patience. They are at war.
Among them, sometimes a gesture, a glance, or a hiss is enough to tell another what one wants, needs, wants to say about someone else, or what message needs to be transmitted.
When an outsider arrives to these ejidos, or communal lands, he or she is received by members of a committee, while the others – mostly of Tojolabal origin – watch and comment amongst themselves in their own language. Nobody can give outsiders any information. Nobody. The Zapatistas have laws, and the laws must be followed.
These masked men and women are in a new process of organization. Since February 14, neither the Clandestine Revolutionary Indigenous Committee nor the General Command of the EZLN had released a single communiqué.
But for the news of his death, it could be that Don Amado had already died, and that what I heard had not been a broken branch just as April turns the calendar's corner into the next year. But if it had been a broken branch that I heard, then I would have been able to think that perhaps Don Amado had not died, and that he had only turned that corner, and that though we will not see him now, in the coming year he will appear again.
We first knew of Don Amado, and then we saw him…. And it was mutual. Or is. Because it could be that he has died. But it could be that he has not….
Don Amado had, or has, a problem from which not all of us suffer. In place of a heart he had a house, at times disguised as a newspaper suspended in time, or as a leaf, or as a shadow government, or as a storyteller.
And in his house, that is to say, his heart, Don Amado had opened the doors and windows long ago to those who are the color of the earth, and with them shared his roof, his gaze, his ear and his word.
As if we had not finished a hug, so shall we leave it for now… as if the silence is waiting… do you hear it?
The Zapatistas in La Realidad and the other caracoles (their main support bases) are in a stage of silence now. But the men, women, young and elderly here are in constant preparation.
It is time to be quiet, they say now. They need to strengthen their organization. They have disappeared into the mountains. And surprises are on the way.
The sound one can make with the shells of bigger caracoles can be used for communication – for instance, to call meetings. There are a lot of snails living in Zapatista territory, and it is common to come across them walking in the mountains. Children can sell them for a few cents as souvenirs from these insurgent communities.
Perhaps we might guess what it is about if we look carefully. The Zapatistas are very otherly – I don't know if I already told you that – and so they imagine things before those things exist, and they think that, by naming them, those things will begin to have life, to walk…and, yes, to create problems. And so I am sure they have already imagined something, and they are going to begin to act as if that something already exists, and no one is going to understand anything for some time, because, in effect, once named, things begin to take on body, life and a tomorrow.
Then we could look for some clue… No, I don't know where to look… I believe their way is looking with their ears and listening with their eyes. Yes, I know it sounds complicated, but nothing else occurs to me. Come, let's keep on walking.
Look, the stream is turning into a whirlpool there, and in its center the moon is shimmering its sinuous dance. A whirlpool… or a shell.
The five caracol towns are: Oventik (also known by the Zapatistas as "Resistance and rebellion for humanity"), Morelia ("Whirlwind of our words"), La Garrucha ("Resistance towards the new dawn"), Roberto Barrios ("Caracol that speaks for all"), and La Realidad ("Mother of the caracoles from the sea of our dreams").
It may be hard to believe, but the indigenous rebels here in the jungle have an extraordinary communication system: radio communication between the five caracoles, several towns with internet access, parabolic antennas installed at strategic points, computers, and communications committees to oversee all of it. They all work in total secrecy.
There is also Radio Insurgente (97.9 FM), broadcasting from four o'clock in the morning to nine o'clock at night. Radio Insurgente lets the Zapatistas hear messages, communiqués, and music, from traditional Mexican corridos to contemporary protest music.
The Zapatistas wake up, and as they go about their activities, listen to the radio almost all day long, turning it off only before they go to sleep. They call it "horizontal" media.
Sometimes the signal is not very clear, other times it's barely audible, or there is no transmission at all, but the insurgents know that they have their own media.
They told us that the radio station is portable. One day it could be installed in one place, and another day broadcast from somewhere else. But always in the highlands, both for security and to reach the largest audience.
La Realidad and the Lacandon jungle are Marcos and the Clandestine Revolutionary Indigenous Committee's stronghold. Because of this, security and secrecy here are greater than in the rest of the autonomous Zapatista lands of Chiapas.
Comandantes David, Omar, Tacho, Ramona, Estela, Fidelia are in other caracoles, and have their own military, police, and civil organizations.
In nearly all the rebel villages, one can see a series of murals and graffiti accompanying images of revolutionary heroes Emiliano Zapata, Ernesto "Che" Guevara, and Subcomandante Marcos. This, too, is a way of communicating, daily and permanently.
The EZLN's current silence has a point: to strengthen the autonomy of the Zapatista towns and the Good Government Councils in the caracoles, to build an alternative model of society.
Although poverty is a common feature to all the indigenous towns in Chiapas, the Zapatistas know that they are better off than before in matters of education, health, housing, roads, production and communication. All of their policies are based on three words: democracy, liberty and equality.
They build their own schools, roads, economic cooperatives, hospitals, and clinics in the five caracoles. In La Realidad, for instance, many houses now have running water and electricity, thanks to a water turbine in a nearby river. Their houses are generally made wood with aluminum roofs, and nearby one can usually firewood, some farm animals and crops.
The Zapatista towns are generally orderly and clean. There are signs everywhere advising people to preserve the local ecology and environment.
The Tojolabal, Tzotzil, Tzetzal, Chol, Mochó, Jacalteca, Kanjobal and other indigenous groups that live in the EZLN's caracoles don't aspire to any more than to live with dignity, liberty, equality, and true democracy.
Comandante Bernal, in an interview with Narco News, told us that the Zapatistas are dreamers who want to build a model of a new society. In other countries as well, he said, people are rising up to reclaim the rights of those who have no voice.
Here, in La Realidad and other Zapatista towns of the Lacondon jungle, those words said by countless people in different countries around the world – "another nation is possible" – become more of a reality each day.


"It was at a house party last year that Kim Miller learned more about the nonprofit Mothers Out Front and its members.
It was 'kind of like Tupperware parties, but instead of containers, it's climate change we talk about,' she said. Soon after that party, she became an organizer for the group."


Dirck Sipman was a well-to-do Mennonite or Quaker of Krefeld, Germany, one of the three original purchasers of land in Pennsylvania, the others being Jacob Telner and Jan Streypers, each of whom on 10 March 1682 (1683?), bought 5,000 acres of William Penn through Benjamin Furly, Penn's agent in Rotterdam. They were promoters of the Germantown (Pennsylvania) settlement of 1683 ff. On 14 January 1686, Sipman bought another 1,000 acres of Govert Remke, who had bought them in 1683. In 1698 he sold his land to Isaac van Bebber. He never went to Pennsylvania.
Bender, Harold S. "Sipman, Dirck (17th century)." Global Anabaptist Mennonite Encyclopedia Online. 1959. Web. 18 Apr 2019. http://gameo.org/index.php?title=Sipman,_Dirck_(17th_century)&oldid=85004.
Bender, Harold S. (1959). Sipman, Dirck (17th century). Global Anabaptist Mennonite Encyclopedia Online. Retrieved 18 April 2019, from http://gameo.org/index.php?title=Sipman,_Dirck_(17th_century)&oldid=85004.
Adapted by permission of Herald Press, Harrisonburg, Virginia, from Mennonite Encyclopedia, Vol. 4, pp. 535, 1126. All rights reserved.


Wishing on a CAR: Understanding the Scope of Intrinsic T-cell Deficits in Patients with Cancer.
Cancer Discov. 2019 Apr;9(4):466-468. doi: 10.1158/2159-8290.CD-19-0073.
Chimeric antigen receptor costimulation domains modulate human regulatory T cell function.
Boroughs AC, Larson RC, Choi BD, Bouffard AA, Riley LS, Schiferle E, Kulkarni AS, Cetrulo CL, Ting D, Blazar BR, Demehri S, Maus MV.
JCI Insight. 2019 Mar 14;5. pii: 126194. doi: 10.1172/jci.insight.126194.
Garfall AL, Stadtmauer EA, Hwang WT, Lacey SF, Melenhorst JJ, Krevvata M, Carroll MP, Matsui WH, Wang Q, Dhodapkar MV, Dhodapkar K, Das R, Vogl DT, Weiss BM, Cohen AD, Mangan PA, Ayers EC, Nunez-Cruz S, Kulikovskaya I, Davis MM, Lamontagne A, Dengel K, Kerr ND, Young RM, Siegel DL, Levine BL, Milone MC, Maus MV, June CH.
JCI Insight. 2019 Feb 21;4(4). pii: 127684. doi: 10.1172/jci.insight.127684. eCollection 2019 Feb 21. No abstract available.
Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T-cells.
Karschnia P, Jordan JT, Forst DA, Arrillaga-Romany IC, Batchelor TT, Baehring JM, Clement NF, Gonzalez Castro LN, Herlopian A, Maus MV, Schwaiblmair MH, Soumerai JD, Takvorian RW, Hochberg EP, Barnes JA, Abramson JS, Frigault MJ, Dietrich J.
Engineering and Design of Chimeric Antigen Receptors.
Guedan S, Calderon H, Posey AD Jr, Maus MV.
Mol Ther Methods Clin Dev. 2018 Dec 31;12:145-156. doi: 10.1016/j.omtm.2018.12.009. eCollection 2019 Mar 15. Review.
CAR-T cells beyond CD19, UnCAR-Ted territory.
Am J Hematol. 2019 May;94(S1):S34-S41. doi: 10.1002/ajh.25398. Epub 2019 Jan 23. Review.
Lee DW, Santomasso BD, Locke FL, Ghobadi A, Turtle CJ, Brudno JN, Maus MV, Park JH, Mead E, Pavletic S, Go WY, Eldjerou L, Gardner RA, Frey N, Curran KJ, Peggs K, Pasquini M, DiPersio JF, van den Brink MRM, Komanduri KV, Grupp SA, Neelapu SS.
Biol Blood Marrow Transplant. 2019 Apr;25(4):625-638. doi: 10.1016/j.bbmt.2018.12.758. Epub 2018 Dec 25. Review.
Inflammatory and Infectious Syndromes Associated with Cancer Immunotherapies.
Fishman JA, Hogan JI, Maus MV.
Closed loop bioreactor system for the ex vivo expansion of human T cells.
Li M, Chin LY, Shukor S, Tamayo A, Maus MV, Parekkadan B.
Cytotherapy. 2019 Jan;21(1):76-82. doi: 10.1016/j.jcyt.2018.10.009. Epub 2018 Nov 27.
Making CAR T Cells a Solid Option for Solid Tumors.
Front Immunol. 2018 Nov 8;9:2593. doi: 10.3389/fimmu.2018.02593. eCollection 2018. Review.
Immunotherapy for Glioblastoma: Adoptive T-cell Strategies.
Choi BD, Maus MV, June CH, Sampson JH.
Clin Cancer Res. 2019 Apr 1;25(7):2042-2048. doi: 10.1158/1078-0432.CCR-18-1625. Epub 2018 Nov 16. Review.
Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas.
Scarfò I, Ormhøj M, Frigault MJ, Castano AP, Lorrey S, Bouffard AA, van Scoyk A, Rodig SJ, Shay AJ, Aster JC, Preffer FI, Weinstock DM, Maus MV.
Blood. 2018 Oct 4;132(14):1495-1506. doi: 10.1182/blood-2018-04-842708. Epub 2018 Aug 8. Erratum in: Blood. 2018 Dec 6;132(23):2527.
Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery.
Tang L, Zheng Y, Melo MB, Mabardi L, Castaño AP, Xie YQ, Li N, Kudchodkar SB, Wong HC, Jeng EK, Maus MV, Irvine DJ.
Nat Biotechnol. 2018 Sep;36(8):707-716. doi: 10.1038/nbt.4181. Epub 2018 Jul 9.
Toxicities associated with immunotherapies for hematologic malignancies.
Best Pract Res Clin Haematol. 2018 Jun;31(2):158-165. doi: 10.1016/j.beha.2018.03.004. Epub 2018 Mar 28. Review.
Tumour tamed by transfer of one T cell.
Nature. 2018 Jun;558(7709):193-195. doi: 10.1038/d41586-018-05251-5. No abstract available.
Chimeric antigen receptor T-cell immunotherapy for glioblastoma: practical insights for neurosurgeons.
Choi BD, Curry WT, Carter BS, Maus MV.
Neurosurg Focus. 2018 Jun;44(6):E13. doi: 10.3171/2018.2.FOCUS17788.
Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication.
Kloss CC, Lee J, Zhang A, Chen F, Melenhorst JJ, Lacey SF, Maus MV, Fraietta JA, Zhao Y, June CH.
Mol Ther. 2018 Jul 5;26(7):1855-1866. doi: 10.1016/j.ymthe.2018.05.003. Epub 2018 May 8.
JCI Insight. 2018 Apr 19;3(8). pii: 120505. doi: 10.1172/jci.insight.120505. eCollection 2018 Apr 19.
Engineering Chimeric Antigen Receptor T cells to Treat Glioblastoma.
Choi BD, O'Rourke DM, Maus MV.
J Target Ther Cancer. 2017 Aug;6(4):22-25.
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.
O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV.
Sci Transl Med. 2017 Jul 19;9(399). pii: eaaa0984. doi: 10.1126/scitranslmed.aaa0984.
Long M, Beckwith K, Do P, Mundy BL, Gordon A, Lehman AM, Maddocks KJ, Cheney C, Jones JA, Flynn JM, Andritsos LA, Awan F, Fraietta JA, June CH, Maus MV, Woyach JA, Caligiuri MA, Johnson AJ, Muthusamy N, Byrd JC.
J Clin Invest. 2017 Aug 1;127(8):3052-3064. doi: 10.1172/JCI89756. Epub 2017 Jul 17.
Sampson JH, Maus MV, June CH.
J Clin Oncol. 2017 Jul 20;35(21):2450-2456. doi: 10.1200/JCO.2017.72.8089. Epub 2017 Jun 22. Review.
The Why, what, and How of the New FACT standards for immune effector cells.
J Immunother Cancer. 2017 Apr 18;5:36. doi: 10.1186/s40425-017-0239-0. eCollection 2017.
Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment.
J Immunother Cancer. 2017 Mar 21;5:28. doi: 10.1186/s40425-017-0230-9. eCollection 2017. Review.
Possible Compartmental Cytokine Release Syndrome in a Patient With Recurrent Ovarian Cancer After Treatment With Mesothelin-targeted CAR-T Cells.
Tanyi JL, Stashwick C, Plesa G, Morgan MA, Porter D, Maus MV, June CH.
J Immunother. 2017 Apr;40(3):104-107. doi: 10.1097/CJI.0000000000000160.
CARs in the Lead Against Multiple Myeloma.
Ormhøj M, Bedoya F, Frigault MJ, Maus MV.
Curr Hematol Malig Rep. 2017 Apr;12(2):119-125. doi: 10.1007/s11899-017-0373-2. Review.
Immunology: T-cell tweaks to target tumours.
Nature. 2017 Mar 2;543(7643):48-49. doi: 10.1038/nature21506. Epub 2017 Feb 22. No abstract available.
The Flipside of the Power of Engineered T Cells: Observed and Potential Toxicities of Genetically Modified T Cells as Therapy.
Bedoya F, Frigault MJ, Maus MV.
Mol Ther. 2017 Feb 1;25(2):314-320. doi: 10.1016/j.ymthe.2016.11.011. Review.
Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies.
Comput Struct Biotechnol J. 2016 Sep 28;14:357-362. eCollection 2016. Review.
Clin Cancer Res. 2016 Apr 15;22(8):1875-84. doi: 10.1158/1078-0432.CCR-15-1433. Review.
CAR-T Cell Therapies From the Transfusion Medicine Perspective.
Fesnak A, Lin C, Siegel DL, Maus MV.
Transfus Med Rev. 2016 Jul;30(3):139-45. doi: 10.1016/j.tmrv.2016.03.001. Epub 2016 Mar 28. Review.
Improving therapy of chronic lymphocytic leukemia with chimeric antigen receptor T cells.
Fraietta JA, Schwab RD, Maus MV.
Semin Oncol. 2016 Apr;43(2):291-9. doi: 10.1053/j.seminoncol.2016.02.006. Epub 2016 Feb 9. Review.
Chimeric antigen receptor-modified T cells strike back.
Int Immunol. 2016 Jul;28(7):355-63. doi: 10.1093/intimm/dxw018. Epub 2016 Mar 28. Review.
Chimeric Antigen Receptor T-Cell Therapy for the Community Oncologist.
Oncologist. 2016 May;21(5):608-17. doi: 10.1634/theoncologist.2015-0421. Epub 2016 Mar 23. Review.
Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection.
Zhukovsky EA, Morse RJ, Maus MV.
Curr Opin Immunol. 2016 Jun;40:24-35. doi: 10.1016/j.coi.2016.02.006. Epub 2016 Mar 8. Review.
Innate immune signaling in CLL.
Blood. 2016 Jan 28;127(4):376-8. doi: 10.1182/blood-2015-11-679845.
Ruella M, Kenderian SS, Shestova O, Fraietta JA, Qayyum S, Zhang Q, Maus MV, Liu X, Nunez-Cruz S, Klichinsky M, Kawalekar OU, Milone M, Lacey SF, Mato A, Schuster SJ, Kalos M, June CH, Gill S, Wasik MA.
Fraietta JA, Beckwith KA, Patel PR, Ruella M, Zheng Z, Barrett DM, Lacey SF, Melenhorst JJ, McGettigan SE, Cook DR, Zhang C, Xu J, Do P, Hulitt J, Kudchodkar SB, Cogdill AP, Gill S, Porter DL, Woyach JA, Long M, Johnson AJ, Maddocks K, Muthusamy N, Levine BL, June CH, Byrd JC, Maus MV.
Blood. 2016 Mar 3;127(9):1117-27. doi: 10.1182/blood-2015-11-679134. Epub 2016 Jan 26.
Chimeric Antigen Receptor T-Cells: New Approaches to Improve Their Efficacy and Reduce Toxicity.
Maus MV, Powell DJ Jr.
Cancer J. 2015 Nov-Dec;21(6):475-9. doi: 10.1097/PPO.0000000000000155. Review.
Designing CAR T cells for glioblastoma.
Oncoimmunology. 2015 Jun 1;4(12):e1048956. eCollection 2015 Dec.
Chimeric antigen receptor T cell therapy: 25years in the making.
Gill S, Maus MV, Porter DL.
Blood Rev. 2016 May;30(3):157-67. doi: 10.1016/j.blre.2015.10.003. Epub 2015 Nov 6. Review.
Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma.
Garfall AL, Maus MV, Hwang WT, Lacey SF, Mahnke YD, Melenhorst JJ, Zheng Z, Vogl DT, Cohen AD, Weiss BM, Dengel K, Kerr ND, Bagg A, Levine BL, June CH, Stadtmauer EA.
N Engl J Med. 2015 Sep 10;373(11):1040-7. doi: 10.1056/NEJMoa1504542.
Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma.
Johnson LA, Scholler J, Ohkuri T, Kosaka A, Patel PR, McGettigan SE, Nace AK, Dentchev T, Thekkat P, Loew A, Boesteanu AC, Cogdill AP, Chen T, Fraietta JA, Kloss CC, Posey AD Jr, Engels B, Singh R, Ezell T, Idamakanti N, Ramones MH, Li N, Zhou L, Plesa G, Seykora JT, Okada H, June CH, Brogdon JL, Maus MV.
Sci Transl Med. 2015 Feb 18;7(275):275ra22. doi: 10.1126/scitranslmed.aaa4963.
Engineered T cells for cancer therapy.
June CH, Maus MV, Plesa G, Johnson LA, Zhao Y, Levine BL, Grupp SA, Porter DL.
Cancer Immunol Immunother. 2014 Sep;63(9):969-75. doi: 10.1007/s00262-014-1568-1. Epub 2014 Jun 19. Review.
CARTs on the road for myeloma.
Clin Cancer Res. 2014 Aug 1;20(15):3899-901. doi: 10.1158/1078-0432.CCR-14-0721. Epub 2014 Jun 11.
T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.
Maus MV, Haas AR, Beatty GL, Albelda SM, Levine BL, Liu X, Zhao Y, Kalos M, June CH.
Cancer Immunol Res. 2013 Jul;1(1):26-31. doi: 10.1158/2326-6066.CIR-13-0006. Epub 2013 Apr 7.


Audi is planning to expand its model line up by adding up 20 electric vehicles where more than 12 vehicles would be SUVs and rest would be four-door GTs. Audi also plans to add several A-segment city cars in the new model line up to comply with the European emission standards and going more environment-friendly.
The launch of the e-Tron system in the Audi models has made the Audis even more responsive and environment-friendly. Audi would announce the models over the next seven years and they would be introduced in the UK and Europe markets accordingly.
As it is clear that Audi has confirmed 20 new models in the next seven years, and all of them would be electrified versions. Out of these 20 models, 12 cars would be fully electric e-Tron versions with a plug-in hybrid system.
With the boost to Audi's Q series SUVs at the same time. The e-Tron system is a front-end rival to Tesla's Model X coupes and crossover versions. The e-Tron models have been badged as e-Tron Sportback, and these models would be introduced in 2019.
Both models would be used with a heavily adapted MLB platform from Audi's parent Volkswagen Group. It is an Evo platform in an unmodified form, which has already been used in the Audi A8 and Q8 model lines. Apart from Audi, other luxury brands including Lamborghini Urus, and Bentley Bentayga.
At the Los Angles Motor Show, another member of the e-Tron family would be introduced in the concept form, it is expected by next month. The e-Tron GT concept car would be introduced heavy technology gadgets where most of the technology has been used from PB18 e-Tron concept.
The stunning concept was introduced at the Pebble Beach show last month. The concept was also previewed at Audi's annual press conference last year. Audi was expecting that the model would become popular in the coming years.
Audi has confirmed that the new e-Tron GT is inspired by Porsche's four-door coupe called Taycan and would use the same J1 platform which has been used by the Taycan. The vehicle is expected to go on sale in the next three years.
The compact A3 sized model is the only other Audi e-Tron model to be confirmed. The new model would be based on the MEB all-electric platform of the Volkswagen group.
Apart from small electric cars, it is expected that the German automaker would introduce a number of saloons, SUVs and Crossovers by the end of 2025. A number of electric models would be available for the Chinese markets as well.
Porsche and Audi are working on a new platform and both automakers would use this new platform in their vehicles. A new platform called Premium Platform Electric (PPE). This platform would support a range of new models in the UK.
Audi has also confirmed that it's working with sister brand Porsche on another all-electric platform known as Premium Platform Electric (PPE), which will support a range of larger high-floor (SUV and crossover) and flat-floor (saloon and estate) all-wheel-drive electric cars.
In the current Audi line up, there would be eight new models in the current Audi line up. The automaker is expecting more than 30 per cent to 35 per cent increase in sales and popularity index at the same time.
Audi is expecting more than the two-thirds increase in the sales and if it happens somehow it would be actually an electrifying effect on the sales. The mild hybrid systems of 48-volt would be the benefit of Audi engines for internal combustion to increase the efficiency.
The Q series of Audi would get benefit from its Audi electrification plan, and they would get 12 new Q models by 2025. Out of these 12 models, seven would be e-Tron models including the e-Tron Sportback and simple e-Tron.
The Q4 and Q6 models are expected to be added in the model line up. However the often rumoured Q1 model line up along with the Q9 models who would rival the Range Rover Sport in the UK. Both models would be back on cards soon.
These 20 models by 2025 would get an excellent chance of winning sales and according to Audi, the automaker has high targets with these models. They are expecting 30 per cent more sales than normal with these models.
The sports version would be introduced on many of these cars and the automaker would introduce the RS and Sports versions of the new e-Tron models.
Mr Fermin Soneira Santos, the vice president of Audi marketing division says that they have plans to produce an exclusively special version of e-Tron very soon and it would be something which would be an even more fun and joy.


text:
Delta beats Wall Street forecasts with record revenue and big jump in first-quarter profit
Published Wed, Apr 10 2019 7:00 AM EDT Updated Wed, Apr 10 2019 1:28 PM EDT
Dawn Kopecki@Dawn_Kopecki
Emma Newburger@emma_newburger
Delta earned 96 cents a share, on an adjusted basis, compared with an average of 90 cents expected by analysts polled by Refinitiv.
It generated $10.47 billion in revenue, compared with $10.42 billion forecast by analysts.
On an unadjusted basis, the company's profit jumped 31 percent to $730 million.
A Delta Air Lines Boeing 767-300 landing in Amsterdam.
Nicolas Economou | NurPhoto | Getty Images
Delta Air Lines announced Wednesday that it generated record revenue in the first quarter and that its profit and sales for the period beat Wall Street's expectations.
"Demand for Delta's product has never been stronger," President Glen Hauenstein said in a statement announcing the earnings. "With our customer-focused commercial initiatives delivering strong customer loyalty and top-line momentum, we now expect full-year revenue growth of five to seven percent, an increase from our prior guidance."
Delta's stock was up 1.6% midday Wednesday.
The Atlanta-based carrier earned 96 cents a share, on an adjusted basis, in the first quarter compared with an average of 90 cents expected by analysts polled by Refinitiv.
Delta generated $10.47 billion in revenue, compared with $10.42 billion forecast by analysts. Its sales jumped 5.1 percent, up from $9.97 billion during the first three months of last year.
On an unadjusted basis, the company's profit surged 31 percent to $730 million, or $1.09 per share, up from $557 million or 79 cents a share a year earlier.
Investors were expecting a strong quarter from Delta, especially after it raised its earnings and revenue guidance last week, citing healthy demand that helped drive record performance.
Delta said it would keep capacity consistent into the summer months, which will alleviate investor concerns that scheduling too many flights during peak travel season would lower fares and reduce revenue.
It forecast an even stronger second quarter, telling investors that its earnings per share will fall between $2.05 and $2.35 and total operating revenue will rise by 6% to 8% over the same quarter last year. It expects to boost its flight capacity by 4% to 4.5%, year over year.
Delta's revenue per available seat mile, a key industry metric of how much airlines are bringing in for each seat they fly a mile, rose 2.4% in the first three months of 2019, compared with the year-earlier period. The carrier said it expects this figure to rise between 1.5% and 3.5% in the second quarter of this year.
Delta Air Lines CEO Ed Bastian talks first quarter earnings, Boeing 737 Max grounding
Delta also said its contract renewal with American Express helped drive revenue in the first quarter. The partnership, which focuses on the SkyMiles credit cards, will run through 2029.
The airline has also escaped the fallout from the prolonged grounding of Boeing's 737 Max jets after two fatal crashes over five months that killed a total of 346 people. Wall Street analysts recently downgraded Boeing and Southwest Airlines, and American Airlines, which has 737 Max jets in its fleet, cut its revenue guidance for the first quarter and canceled 1,200 flights. Southwest also cut its guidance after canceling 10,000 flights over bad weather, unexpected maintenance and Max groundings.
"Our hearts go out to all who are impacted," Delta CEO Ed Bastian said Wednesday morning on CNBC's "Squawk Box. " "This is not something we want to compete around. I'm confident Boeing will get to the right answer with respect to the fix and hope they get the product back in the sky as soon as possible."
Delta executives were holding a call with analysts at 10 a.m. ET.
Correction: This story has been updated to correct who is holding a call with analysts Wednesday. It's Delta executives.
Breaking News: Business
American Airlines Group Inc
Southwest Airlines Co
JetBlue appears to be gearing up to announce service across the Atlantic
Published Tue, Apr 9 2019 4:51 PM EDT Updated Wed, Apr 10 2019 8:04 AM EDT
Leslie Josephs@lesliejosephs
JetBlue has been mulling service across the Atlantic for about three years.
The low-cost airline has said its premium Mint class could "disrupt" business travel from the U.S. to Europe.
JetBlue has scheduled an "all-hands" meeting in New York on Wednesday.


The Ferrari logo is well known and well recognized by all and especially the fans of motor car racing.
As told by Enzo Ferrari the story is simple, "The horse was painted on the fuselage of the fighter plane flown by Francesco Baracca, a heroic Italian pilot who died on Mount Montello: the Italian ace of aces of the First World War. In 1923, when I won the first Savio circuit, which was run in Ravenna, I met Count Enrico Baracca, the pilot's father, and subsequently his mother, Countess Paolina. One day she said to me, "Ferrari, why don't you put my son's prancing horse on your cars; it would bring you luck.
Horse: The jumping black horse is rumored to be called "Rampante Cavallo." Ferrari logo consists of the eminent prancing horse that has highlighted the grace of the logo design throughout the company's journey. It was initially considered to include the prancing horse of the Ferrari logo to bring good luck for the car racer. The prancing horse depicts power and now fans of the brand instantly feel speed and sports cars when they consider Ferrari logo.
Shape of Ferrari Logo: The Ferrari logo design is comprised of a rectangular structure holding the prancing horse inside it elegantly.
Color of Ferrari Logo: The prancing horse in the Ferrari logo is colored in the black and has always been so since its origin on the plane. However, yellow tint is said to be the color of Modena, Italy where the Ferrari workshop was located in 1929. On the top of the Ferrari logo green, white and red stripes are employed which enhances the magnificence of the emblem and its Italian heritage.
Font of Ferrari Logo: Initially, the Ferrari logo had the alphabets SF (Scuderia Ferrari) inscribed on it beautifully at the horses hooves in honor of the company sponsored drivers. But now the Ferrari logo encompasses the Ferrari signature at the bottom.
Since the 1920s, Italian race cars of Alfa Romeo, Maserati and later Ferrari and Abarth were (and often still are) painted in "race red" (Rosso Corsa). This was the customary national racing color of Italy, as recommended between the World Wars by the organizations that later would become the FIA. It refers to the nationality of the competing team, not that of the car manufacturer or driver. In that scheme, French-entered cars like Bugatti were blue, German like Benz and Mercedes white (since 1934 also bare sheet metal silver), and British green such as the mid-1960s Lotus and BRM, for instance.


text:
Just trust Mitt. You don't need to worry your pretty little head about the details.
Mitt Romney said he has never paid less than a 13 percent tax rate in the past 10 years during a press availability in South Carolina Thursday. Romney said that he thought the fascination with his taxes was small-minded compared with the the bigger issues of the campaign. He said he recently went back and looked at his taxes and verified that it was never under 13 percent.
Members of the press who said "OK, prove it!":
Have a good night.
StupidiTags(tm): Economic Stupidity, Mitt Romney, Village Stupidity, Wingnut Stupidity
Joe The Dumber
When in doubt as a Republican running for office like Joe (not Joe) the Plumber (not a plumber either), just generate publicity by saying we should shoot brown people.
Congressional candidate Samuel "Joe" Wurzelbacher called for building a fence and to "start shooting" as part of the solution to illegal immigration at a political event over the weekend in Arizona.
Mr. Wurzelbacher, known as "Joe the Plumber," is the Republican challenger to U.S. Rep. Marcy Kaptur (D., Toledo) in the 9th Congressional District.
He spoke Friday night at a fund-raiser in Prescott, Ariz., for Arizona state Sen. Lori Klein.
"For years I've said, 'Put a damn fence on that border going to Mexico and start shooting … ' That's how I feel. I'm not going to hide it just because I'm running for office. I want the borders protected, and I'm very adamant about that," Mr. Wurzelbacher said.
The comment was made in the course of a 14-minute off-the-cuff speech that touched on the importance of conservatives voting for representatives who share their views at the local level.
It was reported by PrescotteNews.com. He said too many conservatives are afraid to speak their minds.
First of all, why is this dipstick in Arizona? You're running in Marcy Kaptur's district, numbskull. In OHIO. You can at least pretend like the House seat you're running for is something more important to your constituents than making yourself famous for so you can land that cushy lobbyist job later on.
Second, "shoot all the brown people" may work in Arizona. Ohio? Not so much.
Kaptur failing to win here would be malfeasance. This guy is an embarrassment to the state and country.
Of course, that means he'd fit right in with the rest of the GOP.
StupidiTags(tm): GOP Stupidity, Jackass, Local Stupidity, Racist Stupidity, Wingnut Stupidity
A Hero Of Many Galaxies
One of my favorite authors and comics writers, Harry Harrison, passed on Wednesday at the age of 87. The Comics Reporter has a rundown of his work:
In the 1960s, Harrison began the novel series through which he is probably best remembered. The Stainless Steel Rat books focused on the thief/smuggler Slippery Jim DiGriz, the Deathworld books on culture and environmental clashes on the backdrop of a difficult-to-colonize planet, the Bill The Galactic Hero book offered up direct parodies of bad science fiction. Like many of the most popular and well-liked genre authors of the 20th Century, Harrison's work was generally smart but offered multiple entrance points for readers of various ages. They are frequently cited by current writers and fans of science fiction and fantasy as influential books from early on in their discovery of that kind of writing.
His 1966 novel Make Room! Make Room! was the basis for the 1973 science fiction movie Soylent Green, and contains potent elements of social criticism only a few of which made it into the film version. It was dedicated to Harrison's then-young children, which gives poignancy to the novel's strong foreboding nature. In the 1970s, Harrison and the author Brian Aldiss worked as anthology series co-editors and were among the leaders in that corner of publishing in terms of collecting valuable material from decades past.
Like several authors of his generation, Harrison used the relative freedom of being a writer (no doubt in close conjunction that living costs be kept relatively low in an uncertain profession) to live in various places around the world. He would reside at various times in Denmark, England, Ireland, Italy and Mexico. For a time he taught a science fiction course at San Diego State University and organized similar courses in university summer programs. He continued his involvement in various fan- and professional-driven science fiction organization and was a presence at a lot of the early conventions.
Three 12-episode adaptation of Stainless Steel Rat stories appeared in 2000 AD in the late '70s to early '80s. "The Stainless Steel Rat" ran in #s 140-151 (1979/80), "The Stainless Steel Rat Saves The World" ran in #s 166-177 (1980) and "The Stainless Steel Rat For President" appeared in #s 393-404 (1984/85). Some of this material appeared in 1985 from Eagle Comics under its own cover.
In 2009, Harrison won the Damon Knight Memorial Grand Master Award from the Science Fiction and Fantasy Writers of America. He was involved in advocacy for Esperanto; the language appears in some of his novels. He won a Nebula Award for Best Script and was nominated for multiple Locus Awards.
A last major piece of writing was released two years ago -- another Stainless Steel Rat book -- and Harrison claimed to be working on a secret project.
I grew up with Slippery Jim's exploits across the stars as a kid and discovered Bill the Space Trooper (who keeps getting parts from people he's not too fond of) in high school, and from there branched out into space, cyberpunk and military sci-fi writers like Heinlein, John Scalzi, Simon Green, David Weber, and William Gibson, but it was Harry Harrison's Vietnam "war is hell" metaphors that really made the genre interesting, thought-provoking and darkly funny to a young, snarky Zandar. Even through Stainless Steel Rat's adventures are 50 years old, they remained as relevant to the world now as they did then and are definitely worth the read. He's the first atheist hero I can recall reading about, too.
I hope Harrison's project sees the light of day. Make that happen, universe.
StupidiTags(tm): Books, Games And Hobbies, RIP
Thanking A Vet - Doing It Right
Dennis Hall is dying. The 63-year-old veteran has terminal cancer, and one of his final wishes is to see the Vietnam Veterans Memorial Wall in Washington, D.C. It is a simple request, but one the man is unable to afford.
His family held a garage sale and a bake sale as well, hoping to raise enough money to help him accomplish his goals. Local news broadcast the story, and the total donations reached thousands of dollars. Enough to send him on his trip, with the remainder to help with his medical bills. His daughter will go with him to the memorial, where he can pay his respects to those who fought beside him, and those who fell.
It warms the heart to see people rally to show appreciation for those who risked their lives for us. Perhaps our government will be inspired to do more of the same.
StupidiTags(tm): Bon The Geek, BTIHAY 2012, Heroes
Don't Stand For It
Sitting has become such a part of our lifestyle that we don't even notice it. Television turned one generation into couch potatoes, computers another, video games a triple threat. By now we have mostly forgotten what it was like to live in a world without easy transportation or delivery to our living rooms.
Healthwise, it is starting to take a toll on people.
Government statistics suggest that almost half of us report sitting more than six hours a day; 65% say they spend more than two hours a day watching TV.
But it's taking a toll on health. A recent study showed that if people spent less than three hours a day sitting, it would add two years to the average U.S. life expectancy. And research has linked sitting too much to increased risks of diabetes and death from cancer, heart disease and stroke.
Endocrinologist James Levine, a professor of medicine at the Mayo Clinic in Rochester, Minn., talks about sitting disease and how to get out of the chair and move more. Levine did some of the original research on the topic and is still investigating it — from a treadmill at his desk.
The article explains how we can and should start utilizing standing workspaces. Employers are catching on, and as we start to take baby steps back towards active lifestyles, this is the easiest place for us to work in some extra movement. I get up every hour and walk a "lap" at my job, which stops my restless legs and increases my productivity. Walking has always been helpful when my mind is stuck on something, I always stroll my neighborhood when a story is nagging at me, so it makes perfect sense it could breathe new life into boring desk jobs.
Depending on the type of work, we can get so busy we neglect our bodies. I work 14 hours days regularly, but during none of those tasks do I have to be standing. I write for two hours a day at least, and move nothing but my fingertips. My greatest exercise is the occasional forehead slap.
The expense isn't that great if we just start building them that way now, and when inevitable remodels come around. Standing or flexible workstations are important in a world where you can kill yourself doing what you're expected to do.
StupidiTags(tm): Bon The Geek, Medical Stupidity
Felix Felicitas
King Felix Hernandez earned his moniker for the Seattle Mariners as he retired 27 in a row for a perfect game on an idle Wednesday afternoon at Safeco Field.
The 2010 AL Cy Young Award winner has long talked of his desire to achieve pitching perfection. He finally accomplished it against the Rays, striking out the side twice and finishing with 12 strikeouts.
It was the third perfect game in baseball this season -- a first -- joining gems by Chicago's Philip Humber against the Mariners in April and San Francisco's Matt Cain versus Houston in June.
More than half of all perfectos -- 12 -- have come in the last 25 seasons.This also was the sixth no-hitter in the majors this season, three of them at Safeco Field. Humber threw his gem in Seattle, then six Mariners pitchers combined to hold the Los Angeles Dodgers hitless at the park on June 8. Prior to Wednesday, no team has ever had a combined no-hitter and a complete game no-hitter in the same season.
For the Rays, it was an all-too-familiar feeling. This was the third time in four seasons they had a perfect game pitched against them, following efforts by Dallas Braden in 2010 and Mark Buehrle in 2009. They've been no-hit four times over the past four seasons.
The lesson here is clear: Every MLB game can be one for the record books, and if the Rays come to town, you should go, just in case you want to cross something off your bucket list. Congrats to Felix and the Mariners, certainly.
Somebody ought to do some charts on the number of perfect games thrown during the Obama administration, just saying.
StupidiTags(tm): EPIC WIN, Sports
Priscilla, Queen Bitch Of The Desert
GOP Gov. Jan Brewer has decided that no, Arizona really doesn't have to follow executive orders issued by this President because he's a Kenyan Muslim anyway, so screw him and DON'T TREAD ON ME.
Arizona Governor Jan Brewer (R) has signed an executive order that attempts to thwart President Obama's directive extending temporary work permits to more than a million undocumented immigrants. The Obama administration's policy — which would grant two-year work authorizations to undocumented youth between 15 and 30 years of age who have lived in the U.S. continuously for at least five years — was announced in June and went into effect on Wednesday.
Brewer's order directs "state agencies to deny driver's licenses and other public benefits to young illegal immigrants who obtain work authorizations" and "directs state agencies to start emergency rulemaking processes as necessary to implement her order."
At this point I honestly expect Brewer to issue a diktat that states Arizona is no longer subject to federal laws and regulations anymore, and that President Sweet Sweetback is welcome to come to bring his boys down and try and do something about it.
As I recall, South Carolina did something similar about 150 years ago. Let's see where this goes, Jan.
StupidiTags(tm): GOP Stupidity, Jackass, Legal Stupidity, Obama Derangement Syndrome, Wingnut Stupidity
India plans an ambitious launch of a Mars orbiter probe in late 2013, trying to become the first Asian country to reach the red planet.
Chefs and foodies across the planet celebrated Julia Child's 100th birthday, as the late cooking icon was saluted by restaurants worldwide.
Wednesday marked the day President Obama's deferment program for young undocumented immigrants went into effect, with thousands lining up in cities across the country to register.
Facebook's stock lockup period expires today, as employees can now sell their stock on the market and many analysts warn the selloff could be sharp.
More and more US cities and counties are turning to cameras that capture license plate numbers as "force multipliers" on stopping criminal activity, but privacy advocates are crying foul.


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Chthamalus barnesi is een zeepokkensoort uit de familie van de Chthamalidae. De wetenschappelijke naam van de soort werd voor het eerst geldig gepubliceerd in 1980 door Achituv en Safriel.

Chthamalidae