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EP0922452A1 - Skin care composition - Google Patents
Skin care composition Download PDF
EP0922452A1 EP19970120700 EP97120700A EP0922452A1 EP 0922452 A1 EP0922452 A1 EP 0922452A1 EP 19970120700 EP19970120700 EP 19970120700 EP 97120700 A EP97120700 A EP 97120700A EP 0922452 A1 EP0922452 A1 EP 0922452A1
composition according
preferably
EP19970120700
Mario Guarracino
Gianfranco Palumbo
Procter and Gamble Co
1997-11-26 Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
1997-11-26 Priority to EP19970120700 priority Critical patent/EP0922452A1/en
A61K8/00—Cosmetics or similar toilet preparations
A61K8/18—Cosmetics or similar toilet preparations characterised by the composition
A61K8/30—Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
A61K8/40—Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing nitrogen
A61K8/41—Amines
A61K8/416—Quaternary ammonium compounds
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/13—Amines
A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
A61L15/42—Use of materials characterised by their function or physical properties
A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
A61K2800/74—Biological properties of particular ingredients
A61K2800/75—Anti-irritant
A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
A61L2300/432—Inhibitors, antagonists
A61L2300/434—Inhibitors, antagonists of enzymes
The invention relates to compounds to be used for preparation of compositions, which can be applied to the skin to prevent or reduce or treat skin rash or diaper rash resulting from lipolytic dermatitis. The compositions can be in the form of cosmetic lotions, creams, powders, oils, foams and the like. The compositions can also be applied to diapers, incontinent-pads, wipes and the like.
The invention also relates to the use of such a composition to prevent or reduce such a skin rash and a process for reducing the lipolytic enzyme activity of lipase enzymes present on external skin.
The invention relates to compounds to be used for preparation of compositions, which can be applied to the skin to prevent or reduce or treat skin rash or diaper rash resulting from lipolytic dermatitis. The compositions can also be in the form of lotions, creams, powders, oils, foams and the like. The compositions can also be applied to diapers, incontinent-pads, wipes and the like.
Skin rash caused by dermatitis, often referred to as diaper rash, has always been a problem encountered by the users of disposable absorbent articles, such as diapers, incontinence articles, sanitary towels, training pants etc. Therefore, one of the biggest needs for these users is a solution to this type of skin rash problem.
The main factor which influences the development of skin rash is the contact of the skin with the wet body exudates, directly or for example contained in the absorbent article. Especially when the water content is high, skin rash can occur easily.
Manufacturers of diapers and skin care products have developed various products over the past decades which help reduce the occurrence of diaper rash (or skin rash).
The main focus thereby has been to reduce the exposure of the skin to the body exudates. This is for example done by introduction to the diaper of absorbing or better absorbing materials. The amount of water which is in contact with the skin is thus reduced.
Other products which are developed to address the skin-rash problem reduce the exposure of the skin to certain ingredients of the body exudates. An example of such ingredients of the exudate are bacteria which can infect the skin and thus start off or aggravate the skin rash.
For example, lotions have been developed which can form a barrier between the skin and the body exudates. Also, anti-inflammatory compositions can be applied to the skin or absorbent article.
EP 0191128 discloses a preparation comprising 8-hydroxy quinoline sulphate for treatment of skin irritation.
However, still one of the most heard complaints amongst users of absorbent articles such as diapers is the persistence of skin or diaper rash, despite the numerous products on the market which can be applied to prevent diaper or skin rash.
It has been discovered that yet another factor can set off or aggravate skin rash, namely the presence, in the body exudate of various enzymes, especially lipase and protease enzymes.
EP 0117632-B relates to disposable articles which comprise lipase inhibiting agents, preferably zinc containing components, and a vehicle material.
US 3,091,241 relates to the use of triacetine in vaginal tampons to inhibit lipase enzyme activity.
US 3, 961,486 teaches the use of adipic acid to reduce the lipase enzyme activity and to reduce the skin rash.
When the skin is exposed to lipase enzymes, the lipids of the skin can be affected by these enzymes. The protection or barrier function of the top layer of the skin (the Strateum Corneum) will thus be diminished. This can effect the health of the skin and/or facilitate the infection of the skin. This can thus lead to skin or diaper rash.
It is known that bile salts are present in the body exudates. These bile salts are known to emulsify the lipids in the body, which ensures that the lipase enzymes are capable of performing on the lipid/ water interface. The inventors have now found that these bile salts still have an emulsifying function once outside the body. They then continue to aid the lipase enzyme which is also present in the body exudate by attacking the lipids in the outer layer skin, exposed to the body exudate.
The inventors have found that these bile salts can be inactivated (and thereby the lipase can be deactivated) when the salts are reacted with specific cationic compounds. The inventors have found that the cationic compounds can thereto be applied to the skin by introduction of the cationic compounds into a composition, cream, lotion, foam, oil, powder which is to be applied directly to the skin or which can be applied to an absorbent article, such as a diaper, which can be applied to the skin..
It has been found that the use of these cationic compounds very effectively reduces or helps to prevent or treat the diaper/skin rash, resulting from dermatitis caused by lipase enzymes. Thus, a process for reduction of the lipolytic enzyme activity of lipase enzymes on the external skin is thus provided and encompassed herein.
The invention relates to the use of one or more cationic compounds of formulas:
or an amphoteric compound and preferably an acidity source, the amphoteric compound having at its iso-electric point the formula:
for preparation of a composition for treatment, prevention or reduction of lipolytic dermatitis of the external skin, wherein R1, R2, R3 and R4 are independently a C1-C22 alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl, or acyl groups, or two or more groups of R1, R2, R3 and R4 form together one or more ring structures; R5, R6 and A are independently a C1-C22 alkylene, alkenylene, (poly) alkoxylene, hydroxyalkylene, arylalkylene or amido alkylene groups; R7 and R8 are independently a C1-C4 alkyl, alkenyl, alkoxy group or a hydroxy group or hydrogen; R9 and R10 are independently a C1-C22 alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl, or acyl groups, or two or more of the groups R1, R9 and R10 form together one or more ring structures; BH is a proton donating group; x is from 2 to 4; and M- is a counter ion.
The invention also provides a disposable absorbent article, preferably a diaper, containing the composition as described above, preferably at such a level that the cationic compounds therein are present at a level of from 0.01% to 10% by weight of the article, preferably comprised in the topsheet of the diaper.
The invention also provides compositions being cosmetic compositions in the form of a cream, foam, lotion, gel, oil, ointment or powder for treatment, prevention or reduction of lipolytic dermatitis of the external skin. These compositions preferably comprise preferred cationic compounds above, namely wherein the cationic compound comprises one or more substituted R1, R2, R3, R4, R9 or R10 groups and/ or a substituted R5 and/or substituted R6 group, whereby the substituent is selected from the group from the group consisting of derivatives of silicon, glucose, fructose and saccharose, whereby the compositions are substantially free from nonionic and/ or anionic surfactants and/ or phosphoric acid esters and/ or enzymes for topical application to the external skin.
The cationic compounds are used for the preparation of compositions for prevention, reduction or treatment of lipolytic dermatitis of the (external) skin.
By treatment or reduction is meant herein the reduction of the dermatitis or the rash of the skin which is caused by lipolytic enzymes, or at least stabilising the dermatitis or rash of the skin which is caused by lipolytic enzymes.
The composition of the invention can be directly applied to the skin which is in contact with lipolytic or lipase enzymes. Such compositions can be comprised in cosmetic composition, being in the form of a cream, lotion, foam, oil, ointment, powder or gel, which can be topically applied to the skin.
Alternatively, the compositions of the invention can be applied to an absorbent article, which can be brought in close contact with the skin which is in contact with the lipolytic enzymes. Such articles are preferably disposable articles such as diapers, incontinent pads, training pants, sanitary towels, feminine hygiene garments, dry or wet wipes.
By the term "topical application" or "topical(ly) applied", as used herein, is meant directly laying on or spreading on epidermal tissue, especially outer skin.
The amount of the composition comprising the cationic compounds of the invention will vary with the particular location of the condition being treated, the severity of the condition being treated, the expected duration of the treatment, any specific sensitivity to either the composition itself, or the concentration of the lipase-inhibiting agent specific to the user, the condition of the user, concurrent therapies being administered, other conditions present in the user.
For the present invention it is preferred that a minimum inhibitory concentration of the compositions containing the cationic compound is topically applied, to act as a bile salt-inhibiting composition to the area in need of treatment of the lipolytic dermatitis or the area where prevention of lipolytic dermatitis is desired in a form such that it is available to inhibit the activity of the lipase present.
This area (or "affected area", as used herein) is meant the area of the skin which is presently exhibiting any levels of skin rash or lipolytic dermatitis, or the area which will be in prolonged contact with body exudates containing lipase enzymes and bile salts. This also includes the area immediately proximate to the described area. It is the area at which treatment, reduction of, and /or prevention is desired.
Lipolytic dermatitis
This invention deals with compositions (or (disposable) absorbent articles incorporating the compositions of the invention) for the treatment of skin or diaper rash or diaper dermatitis caused by lipase enzymes present in the body exudates (thus lipolytic dermatitis), and other conditions which are associated with prolonged contact of the skin with body exudates and/or the wearing of a absorbent article, or in particular a diaper.
Lipase, lipase enzymes or lipolytic enzymes is the trivial or common term employed to represent what is in fact a group of enzymes belonging to the esterases. Their general activity is to hydrolyze fats present in the ester form (such as the glycerides found in human skin), and accordingly generate fatty acids and glycerol. Because this group of enzymes is so widely distributed in plants, moulds, bacteria, milk, and milk-products, as well as in almost all animal tissues, and because moreover human lipase enzymes are present in the pancreatic exudates, they are almost always present in body exudates.
The activity of lipase contributes to almost all skin rash or in particular diaper rash, causing irritation by the digestive degenerative action of lipase on the skin per se and by breaking down the lipid skin-components compromises the barrier property of the skin in the affected area. This breakdown of the integrity of the skin allows other components of the body exudates (urine and faeces in particular), which may not, by themselves, be irritating, to migrate through the compromised skin. At this point normally harmless components may then become irritating.
The lipase has been found to be activated by the presence of pancreatic bile salts, which are present in the body exudates. The bile salts function as emulsifiers of lipids, enabling the lipase enzymes to act on the water-lipid interface.
When employing the compositions of the present invention, the bile salts are inactivated and thus the lipase is inactivated. It is thereby prevented form acting upon the skin and causing irritation. Such inactivation of lipase prevents the compromise of the barrier function of the skin which in turn prevents irritants (such as fungi, bacteria, and bile salts and acids) form migrating through and further irritating and inflaming the skin.
Compositions Cationic compounds
The present invention provides specific cationic compounds, as defined above for use in the preparation of compositions which can be used for treatment, prevention or reduction of the skin rash or particularly diaper rash, which is set off or aggravated by lipase or lipolytic enzymes, thus being the result of lipolytic dermatitis.
It should be understood that for the purpose of this invention, the groups R1-R10 of formulations (I), (II) and (III) above can be substituted by any appropriate substituent group.
In the formulations above, R1, R2, R3 and R9 are independently preferably C1-C8, more preferably C1-C4 alkenyl or alkoxy, more preferably alkyl groups, most preferably methyl or ethyl groups.
Preferably, R4, R5 and R10 are independently C8-C18, more preferably C12-C16 alkenyl or alkoxy, more preferably alkyl or arylalkyl groups, whereby it can be preferred that one of the R4, R5 and R9 substituents is benzyl group.
Alternatively, it can be preferred that the cationic compound comprises at least one R1, R2 or R3 or R9 being a poly alkoxy group.
Thus, R1, R2, R3 and R9 preferably are independently polyalkoxy groups comprising C2-C6, preferably C2-C3 alkoxy units and having an alkoxylation number of from 2 to 50, preferably from 5 to 18. Then, R3, R4 and R10 are independently preferably C1-C8, more preferably C1-C4 alkenyl or alkoxy, more preferably alkyl groups, most preferably methyl or ethyl groups.
A, R5 and R6 are, independently, preferably C1-C6 alkenylene or more preferably alkylene groups, most preferably methylene or ethylene.
Preferred compounds can be benzalkonium chloride or Merquat 2200 (Trade name, being a 2-Propeneamide polymer of N,N-dimethyl-N-2-Propenyl-1-amonium chloride).
Preferred cationic compounds of the formulas above comprise one or more substituted R1, R2, R3, R4, R9 or R10 groups and/ or a substituted R5 and/or substituted R6 group, whereby the substituent is selected from the group from the group consisting of derivatives of silicon, glucose, fructose and saccharose.
Preferred can be Glucquat 125 (trade name, being lauryl dimethyl glucet-10-hydroxydimonium chloride).
Preferred cationic compounds of the formula (III) above are betaine or sulpho betaine
having preferably R1 and R9 being a methyl group.
The composition preferably comprise the cationic compounds at a level of from 0.01% to 90%, more preferably from 0.5% to 60%, most preferably from 2% to 25% by weight of the composition.
The compositions can be prepared by any conventional formulation technique known in the art.
Additional ingredients
The composition of the invention can comprise additional ingredients. Which ingredient are present and in which level depends on the character of the composition and the use thereof.
A highly preferred additional component to be used for the preparation of the compositions of the present invention or for use in the compositions of the present invention are certain ester compounds.
These esters can function as enzyme substrates, which, when acted upon by a hydrolyzing enzyme, such as lipase enzymes will be hydrolyzed resulting in the release of free acids. The presence of these acids will lower the pH of the area where the esters where topically applied to. This will amount to inactivation of all or most enzymes present in this area, in the body exudates, such as the lipase enzymes, protease enzymes, which can all affect the skin, resulting in irritation or skin rash.
In the compositions of the present invention the use of such ester compound has been found to have a surprising effect: it has been found that the cationic compounds provide an immediate effect, i.e. immediate inhibition or inactivation of the lipase enzymes, which may reduce over time, whilst the effect of the ester compounds is relatively delayed but long-lasting. Thus, the combination of the two compounds provides an very effective, immediate and long-lasting reduction or prevention of the diaper/skin rash, resulting from dermatitis caused by the enzymes present on the body exudates on the skin.
A highly preferred ester compound for use in, or for preparation of the compositions of the invention is of the formulation:
wherein R1 and each R2 independently are an acyl group with from 2 to 22 carbon atoms, or an alkyl, alkenyl, arylalkyl, hydroxyalkyl group with from 1 to 24 carbon atoms or hydrogen, whereby at least one of R1 and R2 is such an acyl group, R3 R4, R5, R6, R7, R8, and R9 are independently an alkyl, alkenyl, arylalkyl, hydroxyalkyl, alkoxy groups of from 1 to 24 carbon atoms, hydroxy group or hydrogen; R10 and R11 are independently an alkyl, alkenyl, arylalkyl, hydroxyalkyl, alkoxy groups of from 2 to 24 carbon atoms, hydroxy group or hydrogen; A and B are independently a C1-C6 linear or branched alkylene, alkenylene, alkoxylene, hydroxyalkylene groups; the values of x are independently from 0 to 15; the values of y are independently 0 or 1, with the proviso that when x =2 and y=0, at least one R2 is an alkyl, alkenyl, arylalkyl, hydroxyalkyl group with from 1 to 24 carbon atoms or hydrogen
Preferred are the ester compounds as defined above, wherein the compound is of formula (IV) or (V)wherein x is 1 or 2, y is 0; R1 and one R2 are a C2-C16 acyl group, R10 and one or more R11 are a C2-C16 alkyl group; R3, R4, R5, R6, R7 and R8 are hydrogen
It is highly preferred that the additional ester compound is a mono or diester of formula (V), most preferably a mono or diester of citric acid or tartaric acid (or salts thereof), or a triester of citric acid.
Another highly preferred ester compound of formula for use in the preparation of the compositions of the present invention or for use in the compositions can be an ester compound of the formulation:
wherein R1, R2 and R3 are independently an alkyl or alkenyl or hydroxyalkyl group with from 1 to 22 carbon atoms, and R4, R5, R6, R7 and R8 are independently selected from the group consisting of C1-C10 linear or branched alkyl, alkenyl or hydroxyalkyl groups, hydroxy, chloride, bromide, amine or hydrogen.
Highly preferred are the compounds above wherein R4, R5, R6, R7 and R8 of said compound are hydrogen and preferably wherein R1, R2 and R3 are independently an C1-C4 alkyl group.
Such a preferred compound can be glycerol triacetate.
The additional ester compounds are preferably present in the compositions of the invention at a level of from 0.01% to 20%, more preferably from 0.05% to 10%, most preferably from 0.1% to 5% by weight of the composition.
Lotions, creams, oils, foams, ointments, gels, powders and the like
The compositions of the invention can be cosmetic compositions in the form of
lotions, creams, oils, foams, ointments, powders, gels. They can comprise any of the ingredients commonly used in the art for such compositions.
Preferred cosmetic compositions are prepared by use of cationic compounds as described above, wherein the cationic compound comprises one or more substituted R1, R2, R3,R4, R9 or R10 groups and/ or a substituted R5 and/or substituted R6 group, whereby the substituent is selected from the group from the group consisting of derivatives of silicon, glucose, fructose and saccharose, whereby the compositions are substantially free from nonionic and/ or anionic surfactants and/ or phosphoric acid esters and/ or enzymes for topical application to the external skin.
It is to be understood that the ingredients of the compositions above will depend on the character of the composition, thus lotions will generally comprise different additional ingredients than powders.
In the cosmetic creams, lotions, gels, oils or powders comprising the composition of the invention preferably an acidity source is present, preferably such that is capable to reduce the pH of the skin to below a pH of 8, more preferably below a pH of 7, more preferably below a pH of 6, or even more preferred below a pH of 5.
It can be preferred that the cosmetic cream, lotion, gel, oil, ointment or powder are substantially free from nonionic and/ or anionic surfactants and/ or phosphoric acid esters and/ or enzymes.
Absorbent Articles
The compositions of the present invention can be comprised in an absorbent article, preferably a disposable absorbent article. A particularly preferred absorbent articles therefor is a wipe or a diaper. The diaper preferably comprises the composition in the topsheet of the diaper.
As used herein, the term "absorbent articles" refers to devices which absorb and contain body exudates, and, more specifically, refers to devices which are placed against or in proximity to the body of the wearer to absorb and contain the various exudates discharged from the body. The term "disposable" is used herein to describe absorbent articles which are not intended to be laundered or otherwise restored or reused as an absorbent article (i.e., they are intended to be discarded after a single use and, preferably, to be recycled, composted or otherwise disposed of in an environmentally compatible manner).
The structure of the disposable absorbent article is not critical to the practice of the present invention.
Normally, the composition is incorporated into the absorbent article or diaper in particular in an amount which will deliver the required treatment or reduction or prevention of the lipolytic dermatitis preferably after frequent use.
The disposable absorbent article preferably contains the composition according to the invention at a level such that the cationic compounds therein are present at a level of from 0.01% to 30%, more preferably from 0.01% to 10%, most preferably from 0.05% to 5% by weight of the article.
An absorbent article generally comprises
an absorbent core (which may consist of sub-structures);
a fluid pervious topsheet;
a fluid impervious backsheet;
optionally further features like closure elements or elastification.
As used herein, the term "diaper" refers to an absorbent article generally worn by infants and incontinent persons that is worn about the lower torso of the wearer. It should be understood, however, that the present invention is also applicable to other absorbent articles such as incontinent briefs, incontinent undergarments, diaper holders and liners, feminine hygiene garments, and the like.
A preferred wipe for the purpose of this invention comprises an absorbent fibrous material or core into which the composition may be releasably incorporated. A highly preferred disposable wipe for the purposes of this invention comprises an absorbent fibrous material and a faeces-impermeable backing material; said backing being superposed or co-extensive with one face of said absorbent fibrous material; said backing material most preferably being a web-backing material and most preferably having a width greater than said absorbent material providing side marginal portions which extend beyond said absorbent material, said margin portions being folded around and on top of the edges of said absorbent material. The compositions of the invention agent may be releasably incorporated into the wipe structure by diverse methods which will be readily apparent to those skilled in the art. For example, the compositions can be present in aqueous or volatile carrier such as water, ethanol, or the like, or creams. lotions, oils, ointments, gels or powders, and applied to the absorbent material by spraying, dipping, printing, soaking or otherwise contacting the absorbent material of the wipe with the lipase-inhibiting agent and its carrier. A skin cleansing agent, preferably an oleaginous cleansing agent, may optionally be releasably incorporated into the absorbent material as well.
The compositions of the present invention are preferably incorporated into a diaper, preferably into the absorbent core structure or most preferably into the topsheet structure. The composition may be incorporated into the diaper structure by diverse methods which will be readily apparent to those skilled in the art. For example, the composition can be, optionally after being dispersed aqueous or volatile carrier such as water, ethanol, or the like, applied to the diaper topsheet, to the absorbent core, or to the core side of the backsheet, by spraying, dipping, printing, soaking or otherwise contacting the selected structural element of the diaper with composition and optionally its carrier, which is called herein impregnation.
The diaper preferably comprises a liquid pervious topsheet, a liquid impervious backsheet joined with the topsheet, an absorbent core positioned between the topsheet and the backsheet. While the topsheet, the backsheet, and the absorbent core may be assembled in a variety of well known configurations, preferred diaper configurations are described generally in U.S. Patent 3,860,003 entitled "Contractable Side Portions for Disposable Diaper" which issued to Kenneth B. Buell on January 14, 1975; and U.S. Patent Application Serial No. 07/715,152, allowed, "Absorbent Article With Dynamic Elastic Waist Feature Having A Predisposed Resilient Flexural Hinge", Kenneth B. Buell et al. filed June 13, 1991.
The backsheet is positioned adjacent the garment surface of the absorbent core and is preferably joined thereto by attachment means such as those well known in the art. For example, the backsheet may be secured to the absorbent core by a uniform continuous layer of adhesive, a patterned layer of adhesive, or an array of separate lines, spirals, or spots of adhesive. Adhesives which have been found to be satisfactory are manufactured by H. B. Fuller Company of St. Paul, Minnesota and marketed as HL-1258. The attachment means will preferably comprise an open pattern network of filaments of adhesive as is disclosed in U.S. Patent 4,573,986 entitled "Disposable Waste-Containment Garment", which issued to Minetola et al. on March 4, 1986, more preferably several lines of adhesive filaments swirled into a spiral pattern such as is illustrated by the apparatus and methods shown in U.S. Patent 3,911,173 issued to Sprague, Jr. on October 7, 1975; U.S. Patent 4,785,996 issued to Ziecker, et al. on November 22, 1978; and U.S. Patent 4,842,666 issued to Werenicz on June 27, 1989. Alternatively, the attachment means may comprise heat bonds, pressure bonds, ultrasonic bonds, dynamic mechanical bonds, or any other suitable attachment means or combinations of these attachment means as are known in the art.
The absorbent article may further comprise elastification or closure features well-known in the art and - for exampel - described in E 0254476 (Alemany).
The topsheet is positioned adjacent the body surface of the absorbent core and is preferably joined thereto and to the backsheet by attachment means such as those well known in the art. As used herein, the term "joined" encompasses configurations whereby an element is directly secured to the other element by affixing the element directly to the other element, and configurations whereby the element is indirectly secured to the other element by affixing the element to intermediate member(s) which in turn are affixed to the other element.
Generally, the topsheet is compliant, soft feeling, and non-irritating to the wearer's skin. Further, the topsheet is liquid pervious permitting liquids (e.g., urine) to readily penetrate through its thickness. A suitable topsheet may be manufactured from a wide range of materials, such as porous foams; reticulated foams; apertured plastic films; or woven or nonwoven webs of natural fibres (e.g., wood or cotton fibres), synthetic fibres (e.g., polyester or polypropylene fibres), or a combination of natural and synthetic fibres. There are a number of manufacturing techniques which may be used to manufacture the topsheet. For example, the topsheet may be a nonwoven web of fibres spunbonded, carded, wet-laid, meltblown, hydroentangled, combinations of the above, or the like.
The various core, topsheet andbacksheet materials can be arranged in any way known in the art, such as described in Weisman et al. (EP 0 202 125) or Alemany et al. (EP 0 254 476).
Also encompassed in the present invention is a process for making a diaper comprising the composition of the invention whereby the topsheet is impregnated with the composition before incorporation in the diaper.
Also encompassed in the invention is a process for reducing the lipolytic enzyme activity of the lipase enzymes present on the external skin, whereby the process comprises the steps of preferably topical, applying of the compositions of the invention to the external skin, or preferably topical, applying of a composition according to the invention to the external skin. reducing the pH to below 7.3, preferably below 6 or even 5.
The composition used in the process or the process is preferably such that within the first 15 minutes after application of the compound or the composition to the affected area, the lipase enzyme activity is reduced to 35%, preferably 25%, more preferably less than 20% of the initial lipase activity in this area.
Preferably the composition used in the process or the process is such that 60 minutes after application of the composition to the affected area, the lipase enzyme activity is still less than 45%, preferably 35%, more preferably less than 30% of the initial lipase activity in this area.
This process can be also be done by applying an absorbent article which comprises the composition present in a suitable level, to the skin.
The use of one or more cationic compounds of formulas:
for preparation of a composition for prevention, treatment or reduction of lypolytic dermatitis to the external skin, wherein R1, R2, R3 and R4 are a C1-C22 alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl, or acyl groups, or two or more groups of R1, R2, R3 and R4 form together one or more ring structures: R5, R6 and A are independently a C1-C22 alkylene, alkenylene, (poly) alkoxylene, hydroxyalkylene, arylalkylene or amido alkylene groups; R7 and R8 are independently a C1-C4 alkyl, alkenyl, alkoxy group or a hydroxy group or hydrogen; R9 and R10 are independently a C1-C22 alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hyroxyalkyl, or acyl groups, or two or more of the groups R1, R9 and R10 form together one or more ring structures; BH is a proton donating group; x is from 2 to 4; and M-is a counter ion.
The use of a cationic compound for preparation of a composition according to Claim 1 wherein the composition is for prevention, treatment or reduction of lipolytic diaper rash.
The use of a cationic compound for preparation of a composition according to Claim 1 or 2 wherein the cationic compound comprises one or more substituted R1, R2, R3, R4, R9 or R10 groups and/ or a substituted R5 and/or substituted R8 group, whereby the substituent is selected from the group from the group consisting of derivatives of silicon, glucose, fructose and saccharose.
The use of a cationic compound for preparation of a composition according any of Claims 1 to 3 wherein the cationic compound comprises at least one R1, R2, R3 and R9 being C1-C8, preferably C1-C4 alkyl, alkenyl or alkoxy groups, most preferably methyl or ethyl groups.
The use of a cationic compound for preparation of a composition according to any of the preceding Claims, wherein the cationic compound comprises at least one R1, R2 or R3 or R9 being a poly alkoxy group.
The use of a cationic compound for preparation of a composition according to any of the preceding Claims, wherein the cationic compound is of formula (III), being a betaine compound or sulpho-betaine compound
A composition according to any preceding Claim, whereby the cationic compound is present at a level of from 0.01% to 90% by weight.
A disposable absorbent article containing the composition according to any preceding Claim, whereby the cationic compound, comprised in the composition, is present at a level of from 0.01% to 10% by weight of the article.
A disposable absorbent article containing the composition according to any of Claims 1 to 7 Claim at a level of from 0.01% to 10% by weight of the article.
A disposable absorbent article according to Claim 8 or 9 in the form of a diaper or wipe.
A disposable absorbent article according to Claim 10, whereby the diaper comprises a topsheet, containing the composition according to any of Claims 1 to 7.
A cosmetic composition according to any of Claims 1 to 7 in the form of a cream lotion, gel, foam, oil, ointment or powder, which is substantially free from nonionic and/ or anionic surfactants and/ or phosphoric acid esters and/ or enzymes for topical application to the external.
A cosmetic cream, lotion, gel, oil or powder according to Claim 12 wherein an acidity source is present.
A process for reducing the lipolytic enzyme activity of lipolytic enzymes present on the external skin comprising the step of applying a composition or absorbent article comprising the composition according to any preceding Claim to the external skin.
A process for making a diaper according to Claim 11, whereby the topsheet is impregnated with a composition according to any of Claims 1 to 7 priro to incorporation of the topsheet in the diaper.
EP19970120700 1997-11-26 1997-11-26 Skin care composition Withdrawn EP0922452A1 (en)
EP19970120700 EP0922452A1 (en) 1997-11-26 1997-11-26 Skin care composition
CA 2311510 CA2311510C (en) 1997-11-26 1998-11-20 Skin care composition
PCT/US1998/024691 WO1999026610A1 (en) 1997-11-26 1998-11-20 Skin care composition
AU15920/99A AU1592099A (en) 1997-11-26 1998-11-20 Skin care composition
KR20007005755A KR100378063B1 (en) 1997-11-26 1998-11-20 Skin care composition
JP2000521812A JP2001523708A (en) 1997-11-26 1998-11-20 Skin care composition
ZA9810799A ZA9810799B (en) 1997-11-26 1998-11-25 Skin care composition
ID=8227682
EP19970120700 Withdrawn EP0922452A1 (en) 1997-11-26 1997-11-26 Skin care composition
ZA (1) ZA9810799B (en)
US6503526B1 (en) 2000-10-20 2003-01-07 Kimberly-Clark Worldwide, Inc. Absorbent articles enhancing skin barrier function
US6515029B1 (en) 1999-04-23 2003-02-04 Kimberly-Clark Worldwide, Inc. Absorbent article having a hydrophilic lotionized bodyside liner
US6689932B2 (en) 2000-12-22 2004-02-10 Kimberly-Clark Worldwide, Inc. Absorbent articles with simplified compositions having good stability
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US6756520B1 (en) 2000-10-20 2004-06-29 Kimberly-Clark Worldwide, Inc. Hydrophilic compositions for use on absorbent articles to enhance skin barrier
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WO2006071428A1 (en) * 2004-12-28 2006-07-06 Kimberly-Clark Worldwide, Inc. Skin cleansing system comprising an anti-adherent formulation and a cationic compound
US7196022B2 (en) 2001-12-20 2007-03-27 Kimberly-Clark Worldwide, Inc. Products for controlling microbial generated odors
US7449613B2 (en) 2001-07-03 2008-11-11 The Procter & Gamble Company Film-forming compositions for protecting skin from body fluids and articles made therefrom
US7771735B2 (en) 2000-12-22 2010-08-10 Kimberly-Clark Worldwide, Inc. Absorbent articles with compositions for reducing irritation response
US8044256B2 (en) 1999-05-21 2011-10-25 The Procter And Gamble Company Absorbent article having a stable skin care composition
US9393197B2 (en) 2012-06-29 2016-07-19 Kimberly-Clark Worldwide, Inc. Stable emulsion for prevention of skin irritation and articles using same
US9511006B2 (en) 2012-06-29 2016-12-06 Kimberly-Clark Worldwide, Inc. Dispersible moist wipe with emulsion for prevention of skin irritation
US9949902B2 (en) 2012-06-29 2018-04-24 Kimberly-Clark Worldwide, Inc. Stable emulsion for prevention of skin irritation and items using same
US10265434B2 (en) 2016-09-29 2019-04-23 The Procter & Gamble Company Absorbent articles comprising glyceride copolymers
US6998372B2 (en) 2001-08-16 2006-02-14 J&J Consumer Companies, Inc. Moisturizing detergent compositions
WO2006103056A2 (en) * 2005-03-30 2006-10-05 Gerhard Sauermann Topical product containing betaine for preventing and treating nappy rash
EP3441054A1 (en) * 2007-11-05 2019-02-13 Abigo Medical Ab Device for the treatment of vaginal fungal infection
DE1467835A1 (en) * 1964-12-22 1968-12-05 Chemoforma Ag Koerperpflegemittel, especially a Koerperpflegemittel for the female genital area
US4943350A (en) * 1987-08-06 1990-07-24 Scott Paper Company Chemically treated paper products - towel and tissue
US5141803A (en) * 1988-06-29 1992-08-25 Sterling Drug, Inc. Nonwoven wipe impregnating composition
US5240562A (en) * 1992-10-27 1993-08-31 Procter & Gamble Company Paper products containing a chemical softening composition
EP0613675A1 (en) * 1993-03-05 1994-09-07 JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. Cosmetic applicator useful for cleansing, moisturizing and protecting the skin from diaper rash
EP0688901A2 (en) * 1994-06-21 1995-12-27 Kimberly-Clark Corporation Tissue containing glycerin and quaternary ammonium compounds
WO1996017681A1 (en) * 1994-12-06 1996-06-13 The Procter & Gamble Company Absorbent material
WO1997030217A1 (en) * 1996-02-19 1997-08-21 Fort James France Softening lotion composition, use thereof in paper making, and resulting paper product
1998-11-20 JP JP2000521812A patent/JP2001523708A/en not_active Withdrawn
1998-11-25 ZA ZA9810799A patent/ZA9810799B/en unknown
DATABASE "CHEMICAL ABSTRACTS" (HOST: STN); Abs. 99: 141 503, Colombus, OH, USA; & JP 58 060 068 A(KAO CORP.) 9 APRIL 1983 XP002066466 *
DATABASE "CHEMICAL ABSTRACTS" (HOST: STN); Abs.104: 188 122, Colombus, OH, USA; & JP 60 215 870 A(KAO CORP.) 29 OCTOBER 1985 XP002066467 *
DATABASE "CHEMICAL ABSTRACTS" (HOST: STN); Abs.127: 55 935, Colombus, OH, USA; & JP 09 157 172 A(LION CORP.) 17 JUNE 1997 XP002066468 *
AU2005322486B2 (en) * 2004-12-28 2010-10-28 Kimberly-Clark Worldwide, Inc. Skin cleansing system comprising an anti-adherent formulation and a cationic compound
ZA9810799B (en) 1999-05-26
US6803496B2 (en) 2004-10-12 Method for maintaining or improving skin health
US4690821A (en) 1987-09-01 Towel for skin moisturizing and drying
DE10196632B3 (en) 2012-06-21 Absorbent articles that improve Hautbarrierenfuntion, and to methods for applying a composition to a bodyside liner of an absorbent article
EP0817876B1 (en) 2002-05-22 Premoistened, flushable, disposable and biodegradable wet wipes
CA2273161C (en) 2003-04-08 Absorbent articles having lotioned leg cuffs
EP1345632B1 (en) 2010-02-17 Absorbent articles with non-aqueous compositions containing botanicals
DE69906355T2 (en) 2004-03-04 An antimicrobial protease inhibitor containing moistened disposable wiping cloth
JP4071194B2 (en) 2008-04-02 Beneficial component which is eccentrically distributed top on a substrate
US6358516B1 (en) 2002-03-19 One-step system for cleansing, conditioning, and treating the skin
CA2088033C (en) 1996-08-20 Water dispersible towelette impregnated with non-aqueous lotion formulations
US4822601A (en) 1989-04-18 Cosmetic base composition with therapeutic properties
CA2687416C (en) 2014-11-18 Use of a lotion composition on an absorbent article for reducing adherence of feces or menses to the skin
CN1196501C (en) 2005-04-13 Diaper coated with skin-nurishing agent containing polysiloxane on its upper coating
JP3217792B2 (en) 2001-10-15 Emollients and disposable absorbent products having top sheets lotion with containing polyol polyester fixative
US6153209A (en) 2000-11-28 Article having a transferable breathable skin care composition thereon
CN101400329B (en) 2014-02-19 Absorbent articles with lotions
US6296862B1 (en) 2001-10-02 Absorbent article which maintains or improves skin health
CN1294993C (en) 2007-01-17 Film-forming compositions for protecting skin from body fluids and articles made therefrom
JP3217793B2 (en) 2001-10-15 Disposable absorbent article having a lotion-ordered topsheet comprising liquid polyol polyester emollient agent and immobilizing agent
US20020128615A1 (en) 2002-09-12 Absorbent articles with non-aqueous compositions containing anionic polymers
US6710223B1 (en) 2004-03-23 Method for improving skin condition
KR100476911B1 (en) 2005-03-17 Web materials with two or more skin care compositions disposed thereon and articles made therefrom
US6506394B1 (en) 2003-01-14 Delivery of a botanical extract to a treated substrate for transfer to skin
US8309788B2 (en) 2012-11-13 Protease inhibitors in absorbent articles
1999-06-16 AX Extension or validation of the european patent to
Free format text: AL;LT;LV;MK;RO;SI
Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2000-02-23 AKX Payment of designation fees
2000-03-30 REG Reference to a national code
2000-11-22 18D Deemed to be withdrawn


Anger Management for Kids, & Bonus Parenting Anger Program 3.5 (24 ratings) Course Ratings are calculated from individual students� ratings and a variety of other signals, like age of rating and reliability, to ensure that they reflect course quality fairly and accurately. asme codes and standards for piping pdf Today, I�m going to show you a fun way to teach your kids anger management strategies that are practical�and more importantly that work! Learning how to help kids manage anger at an early age is a predictor of future life success.
Anger Management for Kids, & Bonus Parenting Anger Program 3.5 (24 ratings) Course Ratings are calculated from individual students� ratings and a variety of other signals, like age of rating and reliability, to ensure that they reflect course quality fairly and accurately.


text:
import configureMockStore from 'redux-mock-store';
import thunk from 'redux-thunk';
import * as datafilesDuck from '../datafiles';
import * as utilsDuck from '../utils';
import { API } from '../../constants/api';
import nock from 'nock';

const middlewares = [thunk];
const mockStore = configureMockStore(middlewares);

import { datafile } from './fixtures';

describe('Actions::Datafiles', () => {
  afterEach(() => {
    nock.cleanAll();
  });

  it('fetches data files successfully', () => {
    nock(API)
      .get('/data/')
      .reply(200, [datafile]);

    const expectedActions = [
      { type: datafilesDuck.FETCH_DATAFILES_REQUEST },
      { type: datafilesDuck.FETCH_DATAFILES_SUCCESS, files: [datafile] },
    ];

    const store = mockStore({ files: [] });

    return store.dispatch(datafilesDuck.fetchDataFiles()).then(() => {
      // return of async datafilesDuck
      expect(store.getActions()).toEqual(expectedActions);
    });
  });

  it('fetches data files from directories successfully', () => {
    nock(API)
      .get('/data/movies/')
      .reply(200, [datafile]);

    const expectedActions = [
      { type: datafilesDuck.FETCH_DATAFILES_REQUEST },
      { type: datafilesDuck.FETCH_DATAFILES_SUCCESS, files: [datafile] },
    ];

    const store = mockStore({ files: [] });

    return store.dispatch(datafilesDuck.fetchDataFiles('movies/')).then(() => {
      // return of async datafilesDuck
      expect(store.getActions()).toEqual(expectedActions);
    });
  });

  it('creates FETCH_DATAFILES_FAILURE when fetching datafiles failed', () => {
    nock(API)
      .get('/data')
      .replyWithError('Something gone wrong');

    const expectedActions = [
      { type: datafilesDuck.FETCH_DATAFILES_REQUEST },
      { type: datafilesDuck.FETCH_DATAFILES_FAILURE },
    ];

    const store = mockStore({ files: [] });

    return store.dispatch(datafilesDuck.fetchDataFiles()).then(() => {
      // return of async datafilesDuck
      expect(store.getActions()[1].type).toEqual(expectedActions[1].type);
    });
  });

  it('fetches a data file successfully', () => {
    nock(API)
      .get('/data/data_file.yml')
      .reply(200, datafile);

    const expectedActions = [
      { type: datafilesDuck.FETCH_DATAFILE_REQUEST },
      { type: datafilesDuck.FETCH_DATAFILE_SUCCESS, file: datafile },
    ];

    const store = mockStore({ currentFile: {} });

    return store
      .dispatch(datafilesDuck.fetchDataFile(null, 'data_file.yml'))
      .then(() => {
        // return of async datafilesDuck
        expect(store.getActions()).toEqual(expectedActions);
      });
  });

  it('fetches a data file from a subdirectory successfully', () => {
    nock(API)
      .get('/data/movies/actors.yml')
      .reply(200, datafile);

    const expectedActions = [
      { type: datafilesDuck.FETCH_DATAFILE_REQUEST },
      { type: datafilesDuck.FETCH_DATAFILE_SUCCESS, file: datafile },
    ];

    const store = mockStore({ currentFile: {} });

    return store
      .dispatch(datafilesDuck.fetchDataFile('movies', 'actors.yml'))
      .then(() => {
        // return of async datafilesDuck
        expect(store.getActions()).toEqual(expectedActions);
      });
  });

  it('creates FETCH_DATAFILE_FAILURE when fetching a datafile failed', () => {
    nock(API)
      .get('/data/data_file.yml')
      .replyWithError('Something gone wrong');

    const expectedActions = [
      { type: datafilesDuck.FETCH_DATAFILE_REQUEST },
      { type: datafilesDuck.FETCH_DATAFILE_FAILURE },
    ];

    const store = mockStore({ currentFile: {} });

    return store
      .dispatch(datafilesDuck.fetchDataFile('data_file.yml'))
      .then(() => {
        // return of async datafilesDuck
        expect(store.getActions()[1].type).toEqual(expectedActions[1].type);
      });
  });

  it('updates a data file successfully', () => {
    nock(API)
      .put('/data/data_file.json', { raw_content: { foo: 'bar' } })
      .reply(200, datafile);

    const expectedAction = [
      { type: utilsDuck.CLEAR_ERRORS },
      { type: datafilesDuck.PUT_DATAFILE_SUCCESS, file: datafile },
    ];

    const store = mockStore({ currentFile: {} });

    return store
      .dispatch(
        datafilesDuck.putDataFile(null, 'data_file.json', { foo: 'bar' })
      )
      .then(() => {
        // return of async datafilesDuck
        expect(store.getActions()).toEqual(expectedAction);
      });
  });

  it('updates a file successfully from the GUI editor', () => {
    nock(API)
      .put('/data/data_file.json')
      .reply(200, datafile);

    const expectedAction = [
      { type: utilsDuck.CLEAR_ERRORS },
      { type: datafilesDuck.PUT_DATAFILE_SUCCESS, file: datafile },
    ];

    const store = mockStore({ metadata: { metadata: datafile } });

    return store
      .dispatch(
        datafilesDuck.putDataFile(
          null,
          'data_file.json',
          null,
          '_data/new_data_file.yml',
          'gui'
        )
      )
      .then(() => {
        // return of async datafilesDuck
        expect(store.getActions()).toEqual(expectedAction);
      });
  });

  it('updates a yaml file successfully from the GUI editor', () => {
    nock(API)
      .put('/data/data_file.yaml')
      .reply(200, datafile);

    const expectedAction = [
      { type: utilsDuck.CLEAR_ERRORS },
      { type: datafilesDuck.PUT_DATAFILE_SUCCESS, file: datafile },
    ];

    const store = mockStore({ metadata: { metadata: datafile } });

    return store
      .dispatch(
        datafilesDuck.putDataFile(null, 'data_file.yaml', null, null, 'gui')
      )
      .then(() => {
        // return of async datafilesDuck
        expect(store.getActions()).toEqual(expectedAction);
      });
  });

  it('updates a json file successfully from the GUI editor', () => {
    nock(API)
      .put('/data/data_file.json')
      .reply(200, datafile);

    const expectedAction = [
      { type: utilsDuck.CLEAR_ERRORS },
      { type: datafilesDuck.PUT_DATAFILE_SUCCESS, file: datafile },
    ];

    const store = mockStore({ metadata: { metadata: datafile } });

    return store
      .dispatch(
        datafilesDuck.putDataFile(null, 'data_file.json', null, null, 'gui')
      )
      .then(() => {
        // return of async datafilesDuck
        expect(store.getActions()).toEqual(expectedAction);
      });
  });

  it('creates PUT_DATAFILE_FAILURE when updating a datafile failed', () => {
    nock(API)
      .put('/data/movies/actors.yml', datafile)
      .replyWithError('something awful happened');

    const expectedActions = [
      { type: utilsDuck.CLEAR_ERRORS },
      { type: datafilesDuck.PUT_DATAFILE_FAILURE },
    ];

    const store = mockStore({ currentFile: {} });

    return store
      .dispatch(datafilesDuck.putDataFile('movies', 'actors.yml', datafile))
      .then(() => {
        // return of async datafilesDuck
        expect(store.getActions()[1].type).toEqual(expectedActions[1].type);
      });
  });

  it('deletes a data file successfully', () => {
    nock(API)
      .delete('/data/data_file.yml')
      .reply(200);

    const expectedAction = [
      { type: datafilesDuck.DELETE_DATAFILE_SUCCESS },
      { type: datafilesDuck.FETCH_DATAFILES_REQUEST },
    ];

    const store = mockStore({ files: [] });

    return store
      .dispatch(datafilesDuck.deleteDataFile(null, 'data_file.yml'))
      .then(() => {
        // return of async datafilesDuck
        expect(store.getActions()).toEqual(expectedAction);
      });
  });

  it('creates DELETE_DATAFILE_FAILURE when deleting a datafile failed', () => {
    nock(API)
      .delete('/data/data_file.yml')
      .replyWithError('something awful happened');

    const expectedAction = {
      type: datafilesDuck.DELETE_DATAFILE_FAILURE,
    };

    const store = mockStore({ currentFile: {} });

    return store
      .dispatch(datafilesDuck.deleteDataFile('data_file.yml'))
      .then(() => {
        // return of async datafilesDuck
        expect(store.getActions()[0].type).toEqual(expectedAction.type);
      });
  });

  it('creates VALIDATION_ERROR if required field is not provided.', () => {
    const expectedActions = [
      {
        type: utilsDuck.VALIDATION_ERROR,
        errors: ['The filename is required.', 'The content is required.'],
      },
    ];

    const store = mockStore({ currentFile: {} });

    store.dispatch(datafilesDuck.putDataFile());
    expect(store.getActions()).toEqual(expectedActions);
  });

  it('creates DATAFILE_CHANGED when the content in editor is changed', () => {
    const expectedAction = [
      {
        type: datafilesDuck.DATAFILE_CHANGED,
      },
    ];

    const store = mockStore({ config: {} });

    store.dispatch(datafilesDuck.onDataFileChanged());
    expect(store.getActions()).toEqual(expectedAction);
  });
});

redpajama_set_name: RedPajamaGithub


As the market for high class travel continues to expand, providing exceptional resorts, VIP service and exciting experiences, customers are looking for their next fix; a way to bring their luxury lifestyle along for the ride. Gone are the days of folding maps, train schedules and French dictionaries, in 2013 all a traveller needs is a smart phone. So whether you are backpacking across Europe or enjoying a luxury villa in Bali, before you jet off this summer, take the time to browse through the best of this season's bespoke apps to tend to your every need.
Finding your feet on vacation can be a little daunting at times, what with differing transport systems and a whole host of diverse attractions. For your very own personal assistant at a very luxury price, Red Butler offers a one of a kind virtual concierge service on your travels. For about 800 Euro a month, the app grants unlimited requests, from hiring a private car, to booking events and planning your holiday schedule. In addition you'll receive travel discount and exclusive access to the best events on show. If you plan on a spot of island hopping on your next adventure, download Marquis Jets, a free app that allows you to choose from a huge fleet of personal aircraft to get you from A to B. Browse through private plane capacity, speed and specifications to travel tourist free on your luxury break.
For a business traveller, keeping up with current affairs and international markets is an essential part of his trip. Stocks Portfolio for Android is the perfect global financial companion. Combining advanced portfolio management with a user friendly interface, this free download saves your transactions, calculates profits and analyses stock charts, while producing detailed world market data and detailed quotes so that you can spend your money wisely abroad. To keep up with world news, download PressReader, an ingenious application displaying over 2,000 newspapers and magazines from over 100 countries, in over 55 languages. Whether you're sunbathing outside your private Seminyak villa or sailing on your mega yacht, PressReader offers a cover-to-cover reading experience to get your media kick abroad.
Understanding your destination is an integral part of your luxury holiday experience, and for fashion queens, Louis Vuitton just took international chic to a whole new level. Created to connect users with tips and advice based on their adventures, Amble opens up a social community of fact and opinion from other like-minded travellers and some of the most iconic figures in showbiz. For a safety net of suggestions, purchase Amble's in-app guides, full of the designer's exclusive aesthetic.
We all know good food makes for a good holiday and on a luxury break the stakes are raised to impress even the pickiest of customers. New to the app market from the master of metropolitan restaurant reviews, Zagat to Go offers a year of their rated restaurants in 45 cities for under 10 Euro. Browse eateries offline, reserve a table at your favourite diner and check in using Foursquare integration, all at the tap of a screen. Couple your search for trending luxury cuisine with the Wine Ratings Guide, the self-acclaimed 'largest wine database in the world'. Search through a range of categories such as food pairings, region and grape variety, to find the best rated wine for your dinner party.
VIP Black is the ultimate luxury app for millionaire travellers. Described as the first and only premium lifestyle application for the iPhone, the membership only download serves as an exclusive go-to guide for your every vacation need. Receive special upgrades, priority access and full concierge service at a huge number of bespoke partners, from five star restaurants to superior private hotels, all at the click of a button. Upon download, you must certify that your assets and income exceed one million British Pounds to secure the benefits and explore how VIP Black can manage your lifestyle. The one year renewable membership offers all aspects of a VIP lifestyle at the tap of a finger and now features an on-demand Concierge Service to make your overseas experience feel just like home.


Would you like to try a form of painting that is simple, quick and fun? Watercolor might be the right fit for you! In this 2 hour session, Amelia Vidrine will begin with a few quick tips and techniques to begin the foundation of your painting. The class will proceed in creating a Louisiana landscape that is uniquely your own.
This class is offered from 10:00 am -12:00 pm on a few separate dates.
Amelia Vidrine Smith is a local Louisiana artist, currently residing in Eunice. She holds a Bachelors in Fine Arts from NSULA. She is a mother of two young rascals, When she is not chasing her children or renovating her home, Amelia is a hired commission artist as well as a Live Wedding artist. She enjoys learning new artistic forms, and taking on new challenges. She is an open minded adventure loving individual who wants to encourage creativity in everyone.


text:
CSU students involved in more than 33 honors societies
By the time one's college career rolls around, most students have faced the decision of whether or not to relinquish a piece of their funds to an academic honors society they may have never even heard of.
President of the National Soceity of Collegiate Scholars (NSCS) James Reyes takes a study break between his classes on Tuesday. NSCS is a national organization on campus which focuses on accademic achievement and serves as a resource for its members.
At CSU, there are at least 33 of these societies. While many members simply pay the initial fee in order to write it on their resumes and applications, others have decided to extend their involvement, attesting to the core values of a society's existence.
Senior economics and English major Kellen Wittkop, for example, is the former president of National Society of Collegiate Scholars and is a member of many other societies including Hesteria and Phi Kappa Phi. The majority of her involvement in these societies is accredited to Sigma Alpha Lambda — she founded the CSU chapter.
Wittkop explained that she values her involvement with honor societies because they create a structured network, community and support system. She decided to found this chapter because it wasn't exclusive to upperclassmen, and she wanted to put an emphasis on involvement within the community.
"There are a number of people who join honor societies and can't make it to a lot of the meetings or just want to put it on their resume, and that's totally fine, because it is what you make of it," Wittkop said.
Senior journalism and technical communications major James Reyes, current president of NSCS, has also found an active role with honor society involvement. Reyes was one of the few older members who continued his active involvement in meetings and social gatherings, such as movie nights and guest speakers that he said he enjoyed attending.
"It creates a community that shares the same values as me. It's my niche on campus," Reyes said.
As for the membership fees that most honor societies require, Reyes explained that in NSCS, the money goes straight to the national office, where it is distributed into scholarships and different areas needed for events.
While Reyes's one-time fee his freshman year was $60, others have paid much more money to be involved in a society.
Kenneth Blehm, a professor of environmental health and the associate dean for undergraduate programs in the College of Veterinary Medicine and Biomedical Sciences, is currently treasurer and a board member for CSU's chapter of Phi Kappa Phi.
This organization in particular only invites the top seven percent of the junior class and the top ten percent of the senior class. Blehm paid the $350 lifetime membership fee in order to continue his involvement.
"The initial benefit for the student is just an official stamp of achievement and capability provided by one of the oldest and most well-recognized academic honors societies in the U.S. — we've got a history of almost 200 years," Blehm said.
Blehm decided to become a lifetime member because he sees it as recognition of a previous achievement, as well as a future networking opportunity for people who are part of the same rigorous exclusive organization.
Collegian Writer Cailley Biagini can be reached at news@collegian.com .
Phi Kappa
Sigma Alpha Lambda

redpajama_set_name: RedPajamaCommonCrawl


WHITE is a One Page Creative WordPress Theme and can be used for Personal Portfolio, Creative Agency, Designer Portfolio and more.
Template has a universal design, it thought every detail and animation effect. Its just as easy to customize to fit your needs, replace images and texts.
Item Reviewed: WHITE - Creative One Page WordPress Theme 9 out of 10 based on 10 ratings. 9 user reviews.


Totally renovated modern 3-bedroom 2-full-bathroom apartment on the 2nd floor of a 2-family brick house in Country Club is conveniently located close to transportation, restaurants and shopping. The master bedroom has an in-suite full bathroom. The open concept kitchen is equipped with new stainless steel appliances, including a dish washer. There is also a dining room. Beautiful new hardwood floor throughout. Heat and hot water are included in rent.


A graduate of the University of Saskatchewan, Kieran has been recruiting sales, marketing, management and leadership professionals since 1991. He builds long-lasting Client relationships – adding value beyond the identification of top talent by providing meaningful input on recruitment, retention, leadership and market strategy.
"Like most other companies, Lock Search Group is in business to find clients, provide great service, generate revenue, and be profitable. But we also have a unique opportunity to help people with something that's very important to them – their CAREER – an opportunity to put people in a better position to achieve job satisfaction, better compensation, professional growth, recognition, mentorship, or whatever is most important to them.
On a personal note, Kieran is an Oiler fan living in Calgary, which "…can get a little lonely".
Hard to find greater satisfaction than that!


Check us out on Facebook for current sales!
Located just north of the Dallas/Fort Worth Metroplex in Denton, Texas, Books & More offers nearly 3,000 square feet of books, records, movies, and...well, more!
Readers will find tens of thousands of used paperbacks at half the cover price. We have a large selection of the usual bestsellers including, Mystery, Romance, Westerns, Horror, and Science Fiction/Fantasy. Our children's corner features new picture books at half price as well as used paperbacks. While we don't buy books for cash, we do have a trade policy.
Books & More is the bricks and mortar home to record dealer Cliff West, the Record Hound. Cliff has stocked the store with thousands of records all priced at 50% off. Also for sale are memorabilia and framed vintage posters of artists such as Elvis, Jimi Hendrix, Stevie Ray Vaughn, Kiss and the Beatles. Cliff buys records and memorabilia by appointment. Call him at 214-725-6602.
We also carry DVDs, most priced at $4.99 or less.
Store hours are noon to 6:00 p.m. Monday through Friday (Wednesday night to 7:00 pm), Saturday 11 a.m. to 6:00 . Closed Sunday.
Books & More is located at 1626 W. University Drive (Hwy 380) in the University Center at Malone and University, next to Dollar General.


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Bitcoin Diamond Ledger Nano S
March 17, 2022 by local
Using a Ledger Nano Wallet to store your crypto assets is a great way to protect and grow them. The Ledger Nano is one of the most popular hardware wallets available today. The Ledger Nano is easy-to-use and secure. It's ideal for anyone who wants to store and manage digital assets.
Whether you are a casual investor or professional trader, the Ledger Nano X Wallet can be a great addition to your crypto portfolio. It's a safe, secure device that's designed to protect your private keys from theft. You can manage your crypto assets from anywhere, whether you are at home, work or on the move.
The first hardware wallet to have Bluetooth connectivity is Ledger Nano X. This makes it easy to manage your crypto assets from anywhere. With Bluetooth, you'll be able to send and receive assets, check your balance, install apps, and more.
The Ledger Nano X hardware wallet is easy to use. It is compatible with both Android devices and iOS. A USB cable can be used to connect the device to your computer. The screen displays your transactions and private keys. You can set it up in just five minutes.
Ledger Nano X is equipped with a secure chip that protects your private keys from physical damage. It supports more than 5500 cryptocurrencies, as well as ERC20 tokens. You can also access a variety of support channels.
The Ledger Nano S can be used to safely store digital tokens and coins, regardless of whether you're new to it or an expert. It has strong security features to protect your assets, and it can be easily set up and used without any technical skills.
The Nano S is a sleek hardware wallet. You can use it on a computer, or connect to a USB cable. It comes with a screen built in, making it easy to see your accounts.
You will be asked to enter a pin code when setting up the Nano S. The PIN protects your cryptocurrency assets in case you lose your device. You must remember the four-digit PIN number. It must also be kept in a safe place.
Compared to the older Nano S model, the Nano S Plus has a larger display screen and more memory. It supports more coins and has a greater number of applications. The Nano S Plus also offers better functionality. It's also easier and cheaper to use.
Ledger is a well-known hardware wallet manufacturer. Their products are reputable, and their customer service is excellent. They have a website, a dedicated customer support team, and social media accounts. The company also has an academy.
The Nano S Plus wallet has a lot of features. It features a large screen with multi-signature support. It also supports NFTs. It can be used on both mobile and PC devices. It uses a certified secure chip. You can purchase it from the Ledger website. You also get a case made of plastic.
Among hardware wallets, the Ledger Nano Wallet is the best-known device. It allows you to store virtually any digital asset. It uses a certified secure chip to protect private keys.
Secure chips are the same as passports and credit cards. When you store private keys on a secure chip, they are not exposed to the Internet. This makes it safer.
To set up your wallet, you will need to provide a PIN number. In order to recover your funds, you will also need to use a recovery seed phrase.
You can also set up as many as three crypto wallets. This allows you to keep your ledger and private keys separate. To allow you to access your wallets, you can also create a passphrase. This is ideal for crypto beginners.
The Ledger Nano S hardware wallet is the most secure and safest. To protect private keys, it uses dual-chip architecture. It is shipped in a box with an anti-tamper seal. The secure chip stores your private keys, and the ST31H320 (OS), chip protects your coins. The device also has a built-in display panel.
The flaw allows an attacker to install malware that would siphon off private keys from users' crypto accounts. An attacker can also install malicious code on a Ledger device, similar to the BadUSB attack. The good news is that the flaw was addressed by a security update issued by Ledger.
The Ledger Nano X has a number of built-in security features, including a debugging mode. The debugging function is disabled when the user installs the first app. This is because the Ledger device needs to be tampered with before it can be used for an attack.
The Ledger Nano X is designed to prevent such attacks. To install malware, an attacker needs to have physical possession of the device. It's a good idea to buy a Ledger device from an official retailer. It is also a smart idea to make a backup of your recovery phrase.
A hardware wallet can be a great way of increasing the security of your crypto assets. However, there are a few things you need to know before you get started. These are the basics of setting up a Ledger Nano X.
First, create a recovery phrase. Unlike a password, a recovery phrase is not stored on the device. You must write it down on paper. Then, you must create a PIN number that can be used to access the device.
After you have created a recovery phrase and a PIN, activate the device. You can do this by holding down the two buttons at the same time. The Control Center will then open. Once you are inside, you will see a menu with a number of buttons. Choose "Set up".
A hardware wallet such as Ledger NanoX can help protect your crypto assets. Hardware wallets store private keys offline so hackers can't access your funds. If your wallet is stolen, thieves can only access your coins with a PIN code.
Ledger NanoX comes in silver and black colors and has a USB C port. It comes with a keychain strap and a multilingual fast start guide. It can also be purchased with a separate hardware wallet.
Before you can use Ledger Nano X, you must first download the Ledger Live mobile app. You can manage your crypto assets with the app's many features. It offers a list of cryptocurrencies, as well as support for ERC-20 tokens, such as Binance Coin and Tezos. You can also find additional security tips and setup suggestions.
Buying a hardware wallet is not a small expense. You will need to have a safe place to store your cryptocurrencies if you plan to invest in them. However, not all hardware wallets are created equal. The Ledger NanoS is the most secure option available.
The Ledger Nano S is one of the most popular crypto wallets in the world. This is because it provides a secure, cold storage solution. This means that the private keys are stored offline, meaning that they're not exposed to hackers. The Nano S also works with all major cryptocurrencies, including Bitcoin, Ether, and Ethereum Classic.
A Ledger Nano Wallet is a great option to protect your crypto. The device has become a popular option for those seeking to store their digital currency. This device allows you to securely store and manage your private keys.
The Ledger Nano X can be used with Android, iOS and Windows. It offers a great balance between security and simplicity.
Ledger supports 23 cryptocurrencies. The company also supports additional cryptocurrencies through third-party applications. You can transfer funds from a third-party wallet to your Ledger account, or manage your accounts with Ledger Live.
It is a big decision to choose a hardware wallet. Trezor and Ledger both offer secure storage options for your crypto currencies. Both offer support for hundreds if not all coins. They are also very easy to use. But which one is better?
Trezor has been a popular choice for crypto hardware wallets. It supports a wide range of cryptocurrencies, including Bitcoin, Ether, Litecoin, and Stellar. It also has an open source firmware. You can access it through a browser, or by using a third-party app.
Ledger is another popular brand. It is more expensive than Trezor, but it has more features. Ledger has its own mobile app. It also has a Secure Element chip, which is a type of chip that's used in passports and credit cards. It protects your wallet from fault attacks and electromagnetic radiation. You can also use it to stake.
Managing your cryptocurrency portfolio is no longer difficult with Ledger Live Nano Wallet. It is easy to set up and offers a great security level. It can be used for buying, selling, and stake tokens. The app also offers real-time price updates and multi-account management. It's available for Windows, iOS and Mac OS. It can support more than 5,500 tokens and coins.
The Ledger Nano X high-security device can store private keys. You can use it as a 2FA hardware device. It has Bluetooth capabilities so that it can be used with compatible third-party wallets.
The Nano X has two buttons at the top of its screen. The Control Center will be opened if you press both buttons simultaneously. Long-pressing both buttons will return you to the main screen.
Using Ledger Live Nano Wallet, you can buy, sell, and stake cryptocurrencies. You can manage your crypto portfolio with support for over 5,500 tokens and coins. It also supports staking for popular Proof-of-Stake assets.
It is crucial to choose the best Ledger Nano Wallet for your crypto assets. The convenience of Ledger Nano Wallet is not difficult to understand, as this device provides users with an intuitive and secure way to store their cryptos. It has been developed by a French company called Ledger. It is a specialist in cryptos and internet security. It employs over 80 people in San Francisco, making it one the most well-known names in the industry.
The Ledger Nano X is a secure hardware wallet. It uses a proprietary operating system, BOLOS. Its Secure Element chip, which is embedded with countermeasures for known attacks, is tamper-resistant. It also comes with a 24 word recovery phrase.
The Ledger Nano X has more versatility than the original Nano S model. It supports over 5,500 cryptocurrencies. It can also natively manage ERC-20 tokens and ERC-721 tokens. It also supports Bluetooth Low Energy (BLE), connectivity.
It is also able to store non-fungible tokens (NFTs). These include characters in games and digital art. It also supports the BIP39 seed phrase system to backup your wallet.
Ledger Nano X features a secure chip that is certified to be CCEAL5+. This means that the private key never leaves the device. It is also tamper-resistant so you can't replace it with another. It is the same chip used in passports and credit cards.
Ledger NanoX can store up 100 assets simultaneously, including ERC-20 tokens. It supports coldcard hardware wallets. The Ledger Nano X Bluetooth wallet has a 24-word recovery phrase that you can use in case you lose your device.
A reliable battery can be vital for your Ledger Nano Wallet. The battery should last for at least a few months if not more. It may be able to last for years.
A hardware wallet is a convenient way to keep private keys safe and perform frequent transactions. These wallets are also great for protecting your private keys against being lost or stolen. Ledger has two hardware wallets available: Ledger Nano S and Ledger Nano X. The Nano S is a little smaller than the Nano X, but it has less storage space.
Although the Nano X weighs slightly more than the Nano S (which is lighter), it has a larger screen and more memory. It supports more wallet apps. In addition, it has Bluetooth connectivity.
Using a Ledger Nano Wallet is a great way to store your crypto assets. It is both virus-proof and tamper-resistant, helping to protect your assets. To ensure your security, here are some things you should know.
First, create a PIN Code. Your wallet will be protected against theft by having a PIN code. A Ledger Nano Wallet can be purchased with Bitcoin, credit cards, PayPal, and Paypal. You should only buy one from a trusted seller if you order it online.
Another security measure you need to consider is the security of the hardware. Many wallets store keys on devices that are connected to the internet, and there are plenty of vulnerabilities to keep in mind.
Backup your recovery phrase to help protect your wallet. You can use a special paper included with your device, or you can record your recovery phrase online. Having a backup phrase can help you re-create your wallet contents in another device, even if your wallet has been lost.
Getting a coupon code for Ledger Nano Wallet is a good way to save money. There aren't many. Ledger is a well-known brand in crypto wallets. It's safe and simple to use.
Ledger offers a variety of wallets to meet your needs. They include hardware wallets and software wallets. All of these wallets are built with security in mind. These wallets store private keys in a highly secure environment, preventing physical damage and data loss. They also support a variety of cryptographic currencies such as Litecoin, Zcash, XRP, Dogecoin and more.
Ledger's security is also tested against logical and physical exploits. The company is certified by the French National Agency of Security.
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Q: Fixing popup(dialog) position

    <button id="hideButton" type="button" title="Hide" onclick="javascript:openJuiPopup('#hidePopup')" style="background: none; border: none">

    </button>

    <form id="hideForm" data-bind="attr: {action: '@(MVC.GetLocalUrl(MVC.HireOrgJobApplication.ViewApplication(Model.CurrentOrganization.CustomUrl, Model.Job.JobKey, "xxx/ajax-hide")))'.replace('xxx', application.applicationKey)}" method="post" style="display:inline;">
        @Html.AntiForgeryToken()
        <input type="hidden" name="ApplicationKey" data-bind="attr:{ value : application.applicationKey }"  />

                <input type="checkbox" class="currentCheckbox" name="SendRejectionToCandidate" value="true" data-bind="checked: application.hideButtonSendRejectionInsteadOfHide" />
                <input name="SendRejectionToCandidate" type="hidden" value="false" />
                Send a rejection to the applicant

        @foreach (var x in DreamHireDataClassesDataContext.NewInstance.ApplicationHiddenReasons.Where(o => o.IsVisible).OrderBy(o => o.SortOrder).ToList())
        {

                <input type="radio" name="HideReasonId" value="@x.Id" id="@x.Id">

                     @x.ReasonText

        }

            <button id="hider" type="submit" class="btn btn-danger jui-tooltip" data-bind="text: application.hideButtonSendRejectionInsteadOfHide === true ? 'Reject' : 'Hide', attr: { title: application.hideButtonSendRejectionInsteadOfHide === false ? 'Reject' : 'Hide'}"></button>

    </form>

When I click the button on the first code, the popup (2nd code) should appear.

but the position goes somewhere unexpected.
My JS code looks like:
            $("#hidePopup").dialog({
                dialogClass: "no-close",
                position: { my: "middle top", at: "middle bottom", of: $("#hideCross") },
                autoOpen: false,
                draggable: true,
            }).dialog("widget").find(".ui-dialog-titlebar").hide();

I am pretty sure this should work properly in theory, but it doesn't.
Any help?

redpajama_set_name: RedPajamaStackExchange


Are you passionate about it to the point that you can't help yourself even when you're at home watching tv and you see a badly fitted frame on a presenter or actor and you just want to jump through the screen and adjust it and get it fitting properly? Service and client experience is everything. If this resonates with you then the worst thing you could possibly do is not send a CV and covering letter applying to be an EYEWEAR CONSULTANT.
Odds are you're an optical assistant just wishing for the chance to work with the people in this game that take it more seriously than the rest. Most of our stock is chosen by our eyewear consultants when we take trips to Paris, Munich or Milan and as a result is pretty exclusive in Halifax and Huddersfield.
You will have an understanding of optical lenses almost to the point of geekiness with a thirst for further knowledge on all the latest developments. You will love people and appreciate working with the best clients and colleagues. All this backed up by an amazing clinical team that really get it.
So then chop chop! Send a covering letter telling us why you'd be a good fit and an up to date CV.


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Jeff Attinella (Clearwater, Florida, Estados Unidos; 29 de septiembre de 1988) es un exfutbolista estadounidense. Jugaba de guardameta. Attinella además es escritor de libros para niños.

Trayectoria

Inicios
Entre 2007 y 2010 jugó al soccer universitario para la Universidad del Sur de Florida. Con los South Florida Bulls disputó 61 encuentros; fue ganador de muchos premios en su etapa como universitario.

Entre 2009 y 2010 jugó dos encuentros para el Bradenton Academics de la USL PDL.

Profesionalismo
El 18 de enero de 2011, Attinella fue seleccionado por el Real Salt Lake en la 14.ª posición del Supplemental Draft de la MLS 2011, pero no firmó contrato con el club y fue liberado. Sin club, fichó por el Tampa Bay Rowdies de la NASL el 22 de febrero de 2011, y debutó profesionalmente el 30 de abril contra el Atlanta Silverbacks.

En el año 2012, su segunda temporada con los Rowdies, Attinella fue el portero titular y disputó todos los encuentros ese año. El guardameta atajó tres penaltis en la final de la NASL, el Soccer Bowl 2012, contra el Minnesota Stars FC y logró el título con su club ese año.

Su buena actuación con los Rowdies en 2012 llamó la atención del Real Salt Lake de la MLS, club que fichó al portero el 3 de diciembre de 2012.

Luego de ser liberado por el club al término de la temporada 2015, fue seleccionado por el Minnesota United FC en el Draft de expansión de 2016; sin embargo, fue intercambiado al Portland Timbers por la selección de la segunda ronda del SuperDraft de la MLS 2018.

El 21 de enero de 2022, Attinella anunció su retiro como jugador.

Clubes

Vida personal
Attinella, junto a su esposa Kendall y su suegro, fundaron una compañía de libros para niños llamada "It Had to Be Told", que publica los libros que el mismo portero escribe.

Palmarés

Títulos nacionales

Referencias

Enlaces externos
 Jeff Attinella en MLS Soccer
 Jeff Attinella en el sitio web del Portland Timbers
 Jeff Attinella en Twitter

Futbolistas de Estados Unidos
Futbolistas de Florida
Guardametas de fútbol
Futbolistas masculinos de South Florida Bulls
Futbolistas del Bradenton Academics
Futbolistas del Tampa Bay Rowdies (2008)
Futbolistas del Real Salt Lake
Futbolistas del Fort Lauderdale Strikers
Futbolistas del Real Monarchs
Futbolistas del Portland Timbers
Futbolistas del Portland Timbers 2

redpajama_set_name: RedPajamaWikipedia


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Rare UK Luxury Replica Omega Speedmaster shatters auction estimates
June 13, 2022 admin Omega Replica, Omega Speedmaster Replica, Perfect Replica Watches
A 1969 perfect replica Omega Speedmaster which once belonged to Apollo 11 astronaut Michael Collins was sold for $US765,000 ($AU1.06 million) during the Heritage Fine Watches & Timepieces Signature Auction in Texas.
The watch – one of only 28 commemorative 18-carat gold AAA fake Omega Speedmasters made – was presented to Collins upon return to Earth from the Apollo 11 mission.
According to Jim Wolf, director of Heritage Auctions, "We certainly had high hopes for this auction, and thanks in part to Michael Collins' incredible super clone watch, the sale really reached a new stratosphere".
"It makes sense," he said, "Apollo 11 was the first mission that put man on the moon, so it really is the most important mission in the history of space travel."
"Michael Collins was an incredibly important part of that mission, and this luxury fake Omega UK is, without question, a piece of space history and a piece of timepieces history."
The commemorative replica watches for sale were engraved with numbers and presented to US officials and NASA astronauts. Collins was assigned watch 19.
The first two high quality fake Omega watches were offered to then US President Richard Nixon and Vice President Spiro Agnew. Both declined the gifts and in turn, the watches were given to the NASA astronauts who served the space agency the longest.
Collins' best 1:1 replica Omega exceeded early auction expectations, which was estimated the sale to fetch around $US100,000 to $US150,000.
Collins, who passed away in 2021 at the age of 90, is the oft-forgotten crew member who stayed aboard the spacecraft during the Apollo 11 mission while Neil Armstrong and Buzz Aldrin set foot on the moon.
Among the other top performers at the auction was a rare Swiss movement replica Rolex Oyster Cosmograph that belonged to Hollywood legend Paul Newman that sold for $US250,000 ($AU346,140) and a fine platinum Kari Voutilainen watch that sold for $US112,500 ($AU155,763).
Champagne Dials Fake OmegaGold Cases Replica Omega Speedmaster
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Resident association meetings discuss crime increase
Billy Taylor | March 1, 2018	| 0 Comments
HANCOCK PARK MEETING speakers and officials included, from left, burglary Det. Joe Alves; Terry Segraves and Jerry Shaw of SSA, Nikki Ezhari and Rob Fisher of CD4, Greg Martayan of CD5, Capt. Tony Oddo, SLOs Kenneth Price and Dave Cordova, Councilmember Ryu and Marty Beck and Peter Gorelick of the HPHOA.
Recent increases in criminal activity have alarmed residents, especially in single-family neighborhoods, where reports show an uptick in crime. As noted in this newspaper last month, the increases, primarily in property crimes and robberies, also have led the Los Angeles Police Department (LAPD) to reallocate about 300 officers, beginning in January, to patrol duty across the city. Each of the LAPD's Wilshire (essentially west of Larchmont) and Olympic (basically east of Larchmont) divisions reassigned 10 officers to help patrol each area.
Last month, Olympic Division Senior Lead Officer (SLO) Joe Pelayo said of the increasing crime in local neighborhoods: "I've never seen activity like this before."
Wilshire Division Senior Lead Officer Dave Cordova said: "People want to see cars out on the street."
Associations respond
Neighborhood association leaders have been organizing meetings to focus on crime, and what can be done about it. Local LAPD leaders have attended, as have private patrol company representatives.
There was a meeting in Hancock Park on Feb. 6. Two days later, there was a meeting in Brookside (on Feb. 8.) The subject certainly will come up at the La Brea-Hancock annual meeting on March 4, and the Greater Wilshire Neighborhood Council has scheduled a special meeting on crime for all area stakeholders for March 14. There is more about both meetings on page 4.
In a well-moderated meeting, arranged by the Hancock Park Home Owners Association (est. 1948), Peter Gorelick, the association's security chair for the Neighborhood Watch Committee, welcomed about 60 residents and a dozen public safety personnel at the Third Street School auditorium Feb. 6. Gorelick introduced representatives from the LAPD's Wilshire Division. (Hancock Park, like Brookside, is 100 percent within Wilshire Division's jurisdiction.) Public safety experts attending to speak and/or answer questions were: Capt. Anthony Oddo, commanding officer of the Wilshire area; Joe Alves, who has headed the Wilshire burglary unit until being promoted and transferred to Downtown in late February; SLOs Dave Cordova and Kenneth Price (newly assigned to Wilshire SLO duty), ADT Security Services armed patrol representative Mike Ball; and SSA Security Group armed patrol representatives Jerry Shaw and Terry Segraves.
Early in the meeting, Councilmember David Ryu arrived and spoke, describing how the City Council's increasing the LAPD budget has allowed for the hiring of new officers.
Capt. Oddo responded that the recruiting and training of competent police officers is a time-consuming process and that only a small percentage of those who apply for the job ever graduate and are sworn in. Also, compact class sizes (of about 50 trainees each) are required, to give maximum supervision in training.
Props. 46 and 57
Both Capt. Oddo and Det. Alves attributed some of the recent crime increase to the results of state propositions adopted in 2014 and 2016. 2014's Prop. 47 provides for reduced sentences for drug possession and for thefts under $950. Prop 57 provides for early release of state prison inmates, and it also makes charging juveniles as adults more difficult.
The impacts of these two laws are exacerbated by the Legislature's 2011 enactment of Assembly Bill 109, which transferred responsibility for housing and supervision of some sentenced felons from the state to counties. In Los Angeles County, there is insufficient jail space, so convicted criminals spend less time in jail. [Opinions about these pieces of legislation, from the Association of Deputy District Attorneys for Los Angeles County, can be found in a slide show at: tinyurl.com/yagt7tdf. – Ed.]
Capt. Oddo announced that leaders at LAPD headquarters recently had encouraged the local commanders to work more closely with community members and private patrol services to increase eyes on the street. Capt. Oddo said that local private armed patrol companies like SSA and ADT are helpful partners to the LAPD.
Peter Gorelick wrapped up the meeting by giving the ADT and SSA representatives the opportunity to speak about the services they offer to local residents.
Many similar themes were sounded at the Brookside Homeowners Association meeting two days later. A standing-room-only crowd of more than 50 people packed the community room at Memorial Branch Library. Resident Lew Shomer reported on a security survey he had undertaken, noting that a substantial number of residents said they would be willing to pay for private patrol service. Mario Escobar, of ADT Security Services armed patrol, spoke, and Kimberly Morosi, a community resources staff person in City Attorney Mike Feuer's office, told about assistance she could provide to residents.
Neighborhood Watch was a main topic of discussion. Brookside neighbors Peje Kharrazi and Guhan Selvaretnam told how they had organized some blocks on Mullen Avenue and Muirfield Road to communicate better with one another in all kinds of emergency situations. This approach was reinforced by Kari Garcia, visiting from Miracle Mile, who told of the active neighborhood watch organizing that she and her neighbors were doing with Wilshire Division officers.
Representing those officers, SLO Hebel Rodriguez and burglary Det. Joe Alves addressed the meeting and took questions until the library staff said the building was closing and everyone had to leave.
Tags: Brookside Homeowners Association, featured, greater wilshire Neighborhood Council, GWNC, Hancock Park Home Owners Association, LAPD, Los Angeles Police Department
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Sales kickoffs (SKOs) are the perfect way for your sales organization to celebrate past wins, set sales goals, and communicate new strategies. They can also cost hundreds of thousands (if not millions) of dollars to execute, cut into critical selling time, and don't often result in a sales team that is equipped to sell better.
Costs add up quickly: the venue, lodging, meals, drinks, flights, rides, hosts, speakers, entertainment, and giveaways. Your company is probably looking at spending thousands, hundreds of thousands, or even millions of dollars to put on its annual kickoff event. From an ROI perspective, it's crazy to justify that kind of price tag when the data shows those results are mixed at best.
2. They don't have a lasting impact on employees.
While in-person events can feel impactful in the moment, how much information are your sales reps truly retaining? Research shows that on average, it only takes a week for people to forget 90% of the information presented to them. Similarly, ES Research reports that up to 90% of sales training efforts have no lasting impact after 120 days. Is the amount you're spending on your SKO worth it, if your targeted audience is only walking away with 10% of what you intended after seven days?!
3. It's unrealistic to cover everything during one kickoff.
Based on the statistics mentioned above, it's unproductive to cram a year's worth of selling best practices, motivational tactics, and goal-and-expectation-setting into a 2-3 day event that will actually be meaningful.
4. The opportunity cost is high.
Your sales reps hear it all the time: tIme is money. When your entire sales team is required to travel to and from a kickoff event, they're losing critical selling hours. Not only can this affect their outcomes and commissions, but your quarterly sales numbers are going to take a hit when you pull your entire sales staff off the job for longer than absolutely necessary.
5. The way your employees consume content has changed.
By 2025, millennials will make up 75% of the global workforce. As a generation that has mostly grown up with the internet, millennials tend to reject traditional learning methods in favor of modern tools like video. Continuing to hold in-person annual SKOs might be falling short with employees that would prefer a more streamlined, digital experience.
6. More often than not, they miss the mark.
It's not uncommon for companies to focus more on the kickoff event than the kickoff objectives. Sure, bringing in a motivational speaker and hosting post-session happy hours are important; you want to get your sales reps energized, and networking is a big part of the job. But too often, companies put more energy and resources into the social elements of a kickoff, instead of enabling its sales organization with tools that will actually help them sell.
7. Sales reps aren't given proper post-event support.
Sales reps can usually point to the two times they receive formal sales training: when they're onboarded, and at the annual sales kickoff. Your reps need to have access to continual training in order to retain the information they need to optimize selling -- and research shows that companies who offer continuous sales training will see up to 50% higher net sales per employee than companies that don't.
So what's the solution to high-cost and ineffective SKOs?
To keep up with the demands of an increasingly modern and tech-savvy workforce, more companies than ever are livestreaming their sales kickoffs - and it's working.
Curious about livestreaming your next SKO? Take a look at our 9 best practices for livestreaming your annual sales kickoff to learn more, or request more info from Brandlive.