1/27/2013 – In the final round the Chinese GM Wang Hao ruined all Vishy Anand's chances of gaining Silver by beating the World Champion. Levon Aronian drew, to take sole second place, while Sergey Karjakin defeated Loek van Wely to join Anand in 3/4 places. Magnus Carlsen drew his game with black against Anish Giri and ended a full 1½ points ahead of the field. Full round 13 report.
1/25/2013 – In our reports on Tata Steel we sadly neglected the groups B and C, usually only giving the results, games and standings. We caught up yesterday by presenting you with portraits of the B Section players, and today, with the help of photographer Frans Peeters, we introduce you the to C-Group players and young talents. And show you a few interesting tactical moments from their games.
1/24/2013 – In our reports on the Tata Steel Tournament we have sadly neglected the groups B and C, usually giving only the results, games and standings. You have seen dozens of pictures of Magnus, Vishy, Levon and Yifan, but practically none of the 28 stars and talents in the lower sections. With the help of the photographer Frans Peeters we make it up to you – and to them – with a portrait of each.
1/22/2013 – The top seed Magnus Carlsen booked yet another win – his fifth in this tournament – this time with black against the bottom seed, Chinese GM Hou Yifan, who now has five losses and one win. Magnus is a full point ahead of the World Champion Vishy Anand, who drew his game against Peter Leko. Loek van Wely beat Ivan Sokolov with black. Full report with video interviews and GM analysis.
1/20/2013 – In a marathon 92-move game against Sergey Karjakin, Magnus Carlsen (as so often) managed to "squeeze blood out of a stone", as a GM colleague put it, and win an essentially drawn position. This put the Norwegian number one in the world back in the sole lead in Tata Steel. Caruana and Aronian also scored, against L'Ami and Hou Yifan respectively. Full report with videos and GM commentary.
1/18/2013 – Our Spanish language news editor Nadja Wittmann, who lives in Den Haag, Holland, took the train to Wijk aan Zee – in spite of ten inches of snow. Alina L'Ami is in Wijk for the entire event, assisting her husband Erwin. Both have sent us pictorial impressions. In addition we bring you some tactical highlights from the B and C section, while Andrew Martin attempts to explain why Carlsen wins.
1/17/2013 – The trio – Carlsen, Anand and Karjakin, all drew their games and stayed on top of the cross table. The decisive games came from Harikrishna, Aronian, Leko, Nakamura and Wang Hao, who defeated van Wely, Sokolov, Caruana (!), Hou Yifan and L'Ami respectively. Especially impressive was Harikrishna-Van Wely. Here are games, statements by the players and analysis in our round five report.
1/15/2013 – On Sunday all games were (mostly exciting) draws, today by contrast there were five decisive games. At the top Magnus Carlsen took Pentala Harikrishna to the cleaners in typical style; world number five Fabiano Caruana defeated Ivan Sokolov, and World Champion Vishy Anand, facing Levon Aronian with black, played what might surely go down as the game of the year. Full report with GM analysis.
1/14/2013 – Magnus Carlsen scored his first full point in Wijk with a convincing win over the Dutch number two Loek van Wely; the World Champion Vishy Anand defeated the world number five Fabiano Caruana; and Sergey Karjakin took a second full point in his game against the Chinese GM Wang Hao. Karjakin leads with 2.5/3, ahead of Carlsen, Anand and Harikrishna. Postgame interviews and analysis.
1/13/2013 – Ivan Sokolov, playing black, had Hikaru Nakamura on the verge of defeat. Magnus Carlsen admitted that Levon Aronian "outplayed me, so I was lucky to survive." Vishy Anand remained calm in face of a "scary attack" by Anish Giri. Hou Yifan fought back from a bad position to miss a clear win against Loek van Wely – as she learnt in front of a rolling camera after the game. Round two report.
1/12/2013 – Indian GM Pentala Harikrishna defeated the Dutch Champion Anish Giri. Sergey Karjakin celebrated his 23rd birthday by outplaying the former Women's World Champion Hou Yifan, 18, in a Classical French. GM Daniel King looks at this exciting game in his video report. All other games were drawn, and most notably Carlsen-Caruana, Anand-Nakamura and Aronian-van Wely. Round one report.
1/11/2013 – It is, as you know, being held in the Dutch sea resort of Wijk aan Zee. Recently we named the participants and strengths of all three groups. On Friday the opening ceremony took place, and with it the drawing of lots. This means we can give you the full schedule and pairings, as well as the world-class commentators we have lined up for you at Playchess. It's going to be an exciting two weeks.


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agriculture European Union foreign trade János Lázár
Fidesz's Lázár Wants Foreign Discounters to be Replaced by Hungarian Ones
Hungary Today 2021.11.18.
"It is hard to understand why Hungary should import food in a country where they have enough agricultural land and fresh water to feed their own population," said former head of the Prime Minister's Office, János Lázár, in an interview with economic portal Portfolio. The Fidesz supporter says it is extremely important that quality Hungarian raw material production is developed by domestic players, even if this can only be achieved through state intervention. He also suggests that the Hungarian state should try to create a unified Hungarian trade chain. At the same time, Lázár admitted that there is an "unprecedented amount of funding available for the development of rural areas."
This article was originally published on our sister-site, Ungarn Heute. Translation by Júlia Tar
Hungary has faced the threat of "self-sufficiency" several times during the coronavirus epidemic and because of the energy crisis. That is why it is important to strive for the country's independence, says former minister János Lázár in a Portfolio interview. He believes that this (independence) is the only way to provide for ourselves, and this is to be achieved primarily in three areas: the energy, financial, and food sectors.
The pandemic threatens the trade of goods and the free market all over the world. In the 21st century, it is important anyway for a country, i.e. Hungary, to regain both self-sufficiency and self-determination, as about ten million people are currently dependent on adequate food production,"
said Lázár. According to the minister, this requires:
…high-quality commodity production, for example, in pork and milk production, which the country is not yet capable of doing today. The only area in which we have regained our sovereignty is in the field of chicken meat production."
Lázár believes it is incredibly important for Hungary to "move upstream" of domestic manufacturers, buyers, processors, wholesalers, and retailers.
Withdraw from foreign retail chains and discounters! EU membership has not eliminated the possibility of patriotic economic policy, it has only narrowed it. There is still plenty of room to support domestic players,"
said Lázár.
In his opinion, it is not possible to do without imports from one day to the next, as the supply of basic foodstuffs for the Hungarian population would not be possible now without imports, and some dairy and meat products will have to be imported for a long time. As a positive example, he repeatedly mentioned the processing of chicken meat.
A country like Hungary, which has arable land of such good quality and fresh water, could be expected to supply itself with food and thus secure the livelihood of its population. We have the land and the water in our hands, the know-how and the tradition, and yet we import food."
Asked if he sees progress in the fact that large foreign grocery chains such as Aldi or Lidl also offer Hungarian products in large quantities, he said this is just "marketing" and "those who believe otherwise are naive."
Lázár believes that it is not risky to upstage foreign discount chains in the country and cites several large European countries as examples, including those in Central Europe. "If Poland, Slovakia, or Austria are able to do it, Hungarian gullibility should be put aside, because agriculture and the food industry must be made a strategic sector in Hungary if the province wants to survive in the future."
Gov't Commissioner Lázár: Lack of Western Vaccines Caused Deaths of 20,000 Hungarians
János Lázár, former head of the Prime Minister's Office, and member of parliament from Fidesz, told Radio 7 that politicians who had entrusted themselves with purchasing vaccines only from Brussels had made a life-threatening decision. He argued that the purchase of Chinese and Russian vaccines on the other hand, saved over half a million people […]Continue reading
But it's also difficult, Lázár said, to change that view because most people like these foreign chains "because they get a wide selection and good prices there."
According to Lázár, Hungarian entrepreneurs should realize that what is good for the owner of Spar, Lidl, or Aldi should also be good for a Hungarian company. Therefore, he welcomes the fact that the French company in Hungary (Auchan) has a Hungarian co-owner.
The politician adds, however, that state funds are also needed to create such Hungarian chains. "Hungary's refusal to pay the retail tax was a serious mistake, perhaps one of the biggest in the last 12 years. The Poles won that debate, and it's no coincidence that they are doing better than us in the food industry."
Former PMO Head János Lázár Elected as Tennis Association President
János Lázár, Fidesz Member of Parliament, and the only candidate for the position of President of the Hungarian Tennis Association (MTSZ), was elected yesterday at Monday's general assembly. He proposed that the presidency should elect not only a president but also a team. He nominated one candidate for vice-president, former tennis player László Markovits and […]Continue reading
The politician also stressed that a good life in the countryside is only possible if you can make a living here, and this is not possible without agriculture and the food industry.
Lázár believes that the rise in food prices can only be combated by social means (i.e., targeted support for pensioners) and that it would be "unwise to intervene in the market."
Finally, the ex-minister also pointed out that with the growth of the world population, the demand for food will increase radically: Hungary produces food worth €1,700 per hectare of cultivated land, the Austrians €3,000, the Polish €2,500, the Netherlands €18,000, and 12 of the 15 largest food companies in Europe are based in the Netherlands.
Featured image via Zsolt Szigetváry/MTI

redpajama_set_name: RedPajamaCommonCrawl


How often have you visited a national park in the background of tea plantations? Here is one such national park in the high ranges of Kerala which offers the magnificent view of hills with tea plantations - the Eravikulam National Park. Situated in the Kannan Devan Hills of the southern Western Ghats, the wildlife park with an area of 97 sq. km. can be reached via Munnar. Located in the Devikulam Taluk of Idukki district in Kerala, after reaching Munnar, you need to take the road going to Rajamala to reach this national park.
The national park is a protected area and is divided into three regions - the core area, the buffer area and the tourism area. Visitors are allowed only to the tourism area that is in Rajamala, the region lying beyond the road entry into Eravikulam. Eravikulam is also famous for the natural habitat of Nilgiri Tahr, the endangered mountain goat and this park is built with the aim of conserving them.
Every twelve years, this place will be carpeted with blue… Yes, your guess is correct. It is one the place where you can witness the mass flowering of Neelakurinji flowers.
Ever wanted to snuggle in the lap of bustling wilderness?


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Adiantku July 13, 2020 4 min read
Gaming consoles are top-of-the-line leisure instruments available and many individuals buy one for their own...
Gaming consoles are top-of-the-line leisure instruments available and many individuals buy one for their own house. The code within the else part of the if then else block handles what occurs if in air is larger than or equal to three. We examine y velocity to see if the cat is falling (that's, if y velocity is less than or equal to zero) or leaping (that's, if y velocity is greater than zero) and switch to the right costume. Lastly, the define set appropriate costume code finishes. Sure, a built-in LED gentle on the front surface of the PS4 wi-fi controller might not look like a big deal, and to be honest, it actually is not. However, on the other hand, it does give the controller an edge in general appeal, giving it the aesthetic design that a lot of gamers have fast taken to over the previous few years that the PS4 console has been round. The Saints Row collection has a robust emphasis on open-world gameplay and permits gamers to roam its massive open world and complete the storyline at their own pace. So how about PS4? The dangerous information is that PS4 is not totally appropriate with PS3, or some other PlayStation console for that matter – no less than not in the best way you may think. You see, you possibly can't just pop a PS3 disc into your PS4, or download any PS3 recreation via the PS Retailer. They simply won't work. Video games have been additionally distributed by the physical mailing and selling of floppy disks, cassette tapes, and ROM cartridges. Soon a small cottage trade was fashioned, with newbie programmers selling disks in plastic baggage put on the shelves of native retailers or despatched by means of the mail. Richard Garriott distributed a number of copies of his 1980 function-playing online game Akalabeth: World of Doom in plastic luggage before the sport was printed. It has options like the Blu-ray drive that's not found in different gaming consoles accessible in the market immediately. The Blu-ray drive is likely one of the newest disc drives accessible presently. What makes it special is it has a a lot bigger capability to store knowledge, that means it should permit sport developers to point out their creativity and add detailing effects to make the sport more sensible than ever before. I added the sounds to the sport by making a category liable for making soundchannels and sounds. I then referred to different capabilities for each sound from the principle class, so that it could play on the proper ocations, for example in hit-exams and within the start of this system. Assuming both of these interviews are truthful and congruent, then if Ken Kutaragi mentioned the PS4 is coming throughout the subsequent decade; and Hirai's assertion indicated having every Sony PlayStation last for 10 years or extra would solely make sense if he was talking about the shelf life, slightly than the quantity of years earlier than the next product releases.
Although most people probably find the idea of taking part in actual cash gambling games on a cellular machine, the truth is that it is precisely the place each gambling operators and the market generally is moving to. This is how it works. You go against another player using your chosen deck, from which you draw cards in the beginning of a spherical. You will have the option to redraw as much as three playing cards. Every match consists of three rounds and the player who wins two of them is the victor. Success is decided by having the highest score, which comes from the point values assigned to each card in play. Some cards also have distinctive talents that may help you or hinder your opponent. And typically, victory requires you to throw a spherical to be ready for the following one. There's a lot more to it than that, however the nuance is simply too a lot for this listing. The AS Roma Esports players compete in tournaments everywhere in the world, and towards clubs including Paris Saint-Germain, Manchester City, Ajax, Valencia, Sporting Clube de Portugal and Schalke. South Korea's Starleague, the most troublesome and essential esports tournament of its time, was Boxer's stomping ground. He beat his biggest rival, The Storm Zerg" Yellow, to earn the primary of two Starleague titles in a row, a feat that wasn't matched until Jaedong did it in 2009. He conquered the World Cyber Video games in 2001 and 2002, cementing his worldwide fame. He continued to win and contend for championships until 2004. Boxer's rivalries with players reminiscent of Nada and iloveoov rank among the many most memorable in esports history. He went on to sign a $one hundred eighty,000 contract— a document at the time —and had a global fan club of 500,000 members. Hardcore gamers should choose out the Xbox One X It is probably the most highly effective home console by some margin, and has a 4K Blu-ray drive as a sweetener. The Commonplace PlayStation 4 is a contented center-floor. It costs less than both, and has the perfect line-up of unique games in case you are not a Nintendo die-onerous. In search of research supplies? Search our database for more Skilled Esport Player downloadable analysis papers. OG (Dota 2) – OG won a $15.6 million share of esports' greatest prize pool at The Worldwide 2019, becoming the primary again-to-again winners of Dota 2's most prestigious event. Simply because it is troublesome does not imply that it isn't value pursuing although! At JKCP we're at all times encouraging college students to follow their passions. Even if a career as knowledgeable Esports player does not happen, there are nonetheless loads of other jobs inside the business that might be worth pursuing.
Tags: playstation
Previous Permainan Zuma Keren
Next Worth Gaming Consoles For Every Budget


Discussion in 'Installation/Configuration' started by Duplex, Jan 16, 2006.
32-bit system with 128MB ram, 700Mhz CPU, 3gig HD.
The install will skip stuff during the end of the setup. DB info, Host and domain info.
I asked a friend to take a look at it and he says the shell script is mess up.
I will admit i'm a newb when it comes to compiling and linux systems. However my friend is not, he didn't give me any details but just said it was broke. I'd like to know if this has been noticed by anyone as of yet?
the shell script is not broken. If you post the error messages you get, we might be able to help you.
Is there a simple method of uninstalling a partially failed install of this program?
Or just remove certain directories?
Last time it messed up I just reformatted the system and reinstalled from scratch.
Then delete the install_ispconfig directory, unpack the installer again and run the setup script.
K I'm going to attempt the install with a fresh download we'll see what happens.


Now that you've seen a bit of the power of PHP and MySQL, it's time to bring these two juggernauts together. With many programming languages, any time you want to interact with a database, you have to download and install extra code or small plug-ins. PHP isn't like that, though; it comes ready to connect to MySQL from the moment you run the php command.
Even though you've only recently begun your journey to PHP mastery, you're ready to use a database from within your scripts. You'll just need to learn a few new commands and how to deal with the problems that can come up when you're working with a database. In fact, you're going to build a simple form with which you can enter SQL and run it against your MySQL database. Who needs the mysql command-line tool when you're a PHP programmer?
Then, to put a cherry on top of your towering sundae of PHP and MySQL goodness, you'll write another script. This one takes all the information from the forms you've already been building, adds that information into a database, and then adds one more form to with which your users can search for another user by name. All that in one chapter? Yes indeed.
Connect to a MySQL installation.
USE the correct MySQL database.
Send SQL to the database.
Do something with the results.


There's nothing more gratifying than a satisfied, happy family!
"Kipp has photographed several special events for our family and always captures the joy of the occasion in a memorable way. Kipp is dependable, flexible and professional and adapts well to whatever situation arises. Kipp's photos exceeded our expectations."
"Kipp was a pleasure to work with. He knew everything there is to know about the service and setting and related well to the Bar Mitzvah, our family. His relaxed manner set us all at ease and contributed to a meaningful and enjoyable experience for all."
"Kipp is a true professional! We loved working with him. Our photos turned out beautifully and he made everything about our experience a pleasure. We will cherish our pictures forever. Thank you, Kipp!"


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HomeMusic NewsU2, David Bowie & Manic Street Preachers to release special one-off Record Store Day releases for War Child
U2, David Bowie & Manic Street Preachers to release special one-off Record Store Day releases for War Child
March 4, 2020 JP Cartwright Music News 0
From the Official Record Store Day UK Website.
Record Store Day UK are delighted to announce War Child as their Official Charity Partner of 2020 with three exclusive and limited-edition releases from U2, David Bowie and Manic Street Preachers.
These special releases will only be available in Record Store Day participating shops on Saturday 18th April with £1 from every unit sold going towards the charity War Child. Proceeds are expected to exceed £10,000.
The three releases forming part of this series include:
□ David Bowie – CHANGESNOWBOWIE – CD & LP
CHANGESNOWBOWIE which has never been available on record will be released in limited quantities on LP and CD for Record Store Day on 18th April, 2020.The cover art for the album will feature a portrait of David by renowned photographer Albert Watson, taken in New York in 1996. CHANGESNOWBOWIE is a nine-track mostly acoustic session which was recorded in 1996 in New York during rehearsals for Bowie's 50th birthday concert at Madison Square Garden. The BBC broadcast the session the following year, on Bowie's 50th birthday on January 8, 1997 by Mary Anne Hobbs
□ Manic Street Preachers – Done & Dusted – LP
This very limited edition 12" features mixes of the tracks 'La Tristesse Durera (Scream To A Sigh)' and 'Roses In The Hospital' taken from the bands' second album 'Gold Against The Soul' which was released in June 1993. Mixes by London club scene heroes The Chemical Brothers and dance music icon Ashley Beedle were classic reworkings of the songs. The artwork for this release is inspired by a club promo 12" released in 1994 called 'Done and Dusted' (The Chemical Brothers were then known as the Dust Brothers).
□ U2 – 11 O'Clock Tick Tock
'11 O'Clock Tick Tock' was recorded with producer Martin Hannett in Dublin's Windmill Lane Studios in 1980. Originally released in May that year, the song was U2's first single on Island Records. This 40th anniversary edition includes the full length version of '11 O'Clock Tick Tock' and the original 7" b-side 'Touch', plus two previously unreleased live recordings from the band's show at the Marquee in London in September 1980 – 'Touch' and 'Twilight'. 12" Info -4 track 12" EP, cut at 45 rpm, Pressed on 180gsm transparent blue vinyl, Full colour gatefold outer sleeve,Photo gallery on inner gatefold.
Manic Street Preachers said of War Child, "We first worked with War Child on the release of the 'Help' album in 1995 and are very proud to be associated with them. This 2020 Record Store Day event is sure to be the biggest yet and we are always happy to work with War Child on it."
Rich Clarke, Head of Music at War Child said: "War Child is working with children and young people in conflict affected areas to change systems and practices that affect them. We campaign on the root causes of conflict, and we demand that children are at the centre of all humanitarian responses. For 27 years the music industry has been vital to delivering our work from ground-breaking records and innovative partnerships to amazing live shows. That's why we so grateful to be the official charity partner for Record Store Day 2020 and for the impact this will have for children whose lives have been torn apart by war. Thank you, Record Store Day!"
You can find a list of Record Store Day stockists on the participating store locator here
Explore eil.com & 991.com sister – the world's best online store for rare, collectable & out of print Vinyl Records, CDs & Music memorabilia since 1987.
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Genesis announce reunion tour
Pink Floyd's last-ever performance of Arnold Layne set for Record Store Day release
The latest interesting memorabilia arrivals from The Beatles, Bon Jovi, Madonna and more
November 16, 2019 Glen Bushell Uncategorized 0
Along with bringing you the best rare and collectable vinyl, we also pride ourselves on finding a wide selection of music memorabilia. From something as simple as books and t-shirts, to weird and wonderful promotional […]
Dexys Midnight Runners Release New Covers Album 'Dexys Do Irish Country Soul'
June 6, 2016 Tim Card Music News 0
The covers that comprise Dexys' fifth album are rather more inspired than its none-more-descriptive title suggests, from Irish folk standards such as Carrickfergus and The Curragh of Kildare through to a powerful rendition of Rod Stewart's […]
Elton John, Paul McCartney and Eddie Vedder among names confirmed for TV charity event
April 8, 2020 JP Cartwright Music News 0
From Loudersound. The Lady Gaga-curated TV special One World: Together At Home will be broadcast around the world later this month – money raised will go to the COVID-19 Response Fund. Lady Gaga will curate […]


Meg Cabot is a #1 New York Times bestselling author of books for both adults and tweens/teens. There have been over 25 million copies of Meg's nearly 80 published books sold in 38 countries. After working for ten years as an assistant residence hall director at New York University (an experience from which she occasionally draws inspiration for her best-selling Heather Wells mystery series), Meg wrote the Princess Diaries series, which was made into two hit movies by Disney. Meg's most proud of the letters she's received from fans thanking her for helping them to overcome their "dislike of reading.
In The Boy is Back Reed Stewart thought he'd left all his small town troubles—including a broken heart—behind when he ditched tiny Bloomville, Indiana, ten years ago.. Then one tiny post on the Internet causes all of those troubles to return . . . with a vengeance. Becky Flowers has worked hard to build her successful senior relocation business, but she's worked even harder to forget Reed Stewart ever existed.
Meg's "Boy" books are popular worldwide because of their "short chapters," "realistic but romantic plots," and "satisfying" endings. The "Boy" books are told in text, email, and journal format.


Fresh from completing the mission in the Land of Waves, Naruto and the gang are heading out on a new task to locate a man named Mr. Genmai. Sensing something amiss, Kakashi splits away from his team and locates the object of his quest, but as he reaches out his hand, he becomes trapped within a spell and is unable to free himself. Meanwhile, the others become a target of an attack by three unknown ninjas who promptly kidnap Sakura. Now, while Kakashi attempts to find a way out of his situation and aid Mr Genmai, Naruto and Sasuke must put aside their differences and work together to rescue their teammate.


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The 87th Academy Awards – Complete Winners List
February 22, 2015 February 23, 2015 yaunnaraeLeave a comment
Cinema's biggest night is underway! The crazy awards season is about to end and it could be a very interesting night. Follow along with us as the winners are announced live:
Birdman or (The Unexpected Virtue of Ignorance) – *WINNER*
Eddie Redmayne, The Theory of Everything – *WINNER*
(Image credit: ROBYN BECK/AFP/Getty Images)
Julianne Moore, Still Alice – *WINNER*
J.K. Simmons, Whiplash – *WINNER*
Patricia Arquette, Boyhood – *WINNER*
Alejandro G. Inarritu, Birdman – *WINNER*
Jason Hall, American Sniper
Graham Moore, The Imitation Game – *WINNER*
Paul Thomas Anderson, Inherent Vice
Anthony McCarten, The Theory of Everything
Damien Chazelle, Whiplash
Alejandro G. Iñárritu, Nicolás Giacobone, Alexander Dinelaris, Jr. & Armando Bo, Birdman – *WINNERS*
E. Max Frye and Dan Futterman, Foxcatcher
Wes Anderson; Story by Wes Anderson & Hugo Guinness, The Grand Budapest Hotel
Dan Gilroy, Nightcrawler
CitizenFour – Laura Poitras, Mathilde Bonnefoy and Dirk Wilutzky – *WINNER*
Finding Vivian Maier – John Maloof and Charlie Siskel
Last Days in Vietnam – Rory Kennedy and Keven McAlester
The Salt of the Earth – Wim Wenders, Juliano Ribeiro Salgado and David Rosier
Virunga – Orlando von Einsiedel and Joanna Natasegara
BEST FOREIGN-LANGUAGE FILM
Ida (Poland) – *WINNER*
Tangerine (Estonia)
"Everything is Awesome" – <i?The Lego Movie
"Glory" – Selma – *WINNER*
"Grateful" – Beyond the Lights
"I'm Not Gonna Miss You" – Glen Campbell: I'll Be Me
"Lost Stars" – Begin Again
Alexandre Desplat, The Grand Budapest Hotel– *WINNER*
Alexandre Desplat, The Imitation Game
Hans Zimmer, Interstellar
Gary Yershon, Mr. Turner
Jóhann Jóhannsson, Theory of Everything
Whiplash, Tom Cross – *WINNER*
American Sniper, Alan Robert Murray and Bub Asman – *WINNER*
Birdman, Martín Hernández and Aaron Glascock
The Hobbit: The Battle of the Five Armies, Brent Burge and Jason Canovas
American Sniper, John Reitz, Gregg Rudloff, and Walt Martin
Birdman, Jon Taylor, Frank A. Montaño, and Thomas Varga
Interstellar, Gary A. Rizzo, Gregg Landaker, and Mark Weingarten
Whiplash, Craig Mann, Ben Wilkins, and Thomas Curley – *WINNER*
The Grand Budapest Hotel, Adam Stockhausen and Anna Pinnock – *WINNER*
Captain America: The Winter Soldier, Dan DeLeeuw, Russell Earl, Bryan Grill, and Dan Sudick
Dawn of the Planet of the Apes, Joe Letteri, Dan Lemmon, Daniel Barrett, and Erik Winquist
Guardians of the Galaxy, Stephane Ceretti, Nicolas Aithadi, Jonathan Fawkner, and Paul Corbould
Interstellar, Paul Franklin, Andrew Lockley, Ian Hunter, and Scott Fisher – *WINNER*
X-Men: Days of Future Past, Richard Stammers, Lou Pecora, Tim Crosbie, and Cameron Waldbauer
The Bigger Picture, Daisy Jacobs and Christopher Hees
The Dam Keeper, Robert Kondo and Dice Tsutsumi
Feast, Patrick Osborne and Kristina Reed – *WINNER*
A Single Life, Joris Oprins
Me and My Moulton, Torill Kove
Big Hero 6, Don Hall, Chris Williams, and Roy Conli – *WINNER*
How to Train Your Dragon 2, Dean DeBlois and Bonnie Arnold
The Boxtrolls, Anthony Stacchi, Graham Annable, and Travis Knight
Song of the Sea, Tomm Moore and Paul Young
The Tale of the Princess Kaguya, Isao Takahata and Yoshiaki Nishimura
Aya, Oded Binnun and Mihal Brezis
Boogaloo and Graham, Michael Lennox and Ronan Blaney
Butter Lamp (La Lampe Au Beurre De Yak), Hu Wei and Julien Féret
Parvaneh, Talkhon Hamzavi and Stefan Eichenberger
The Phone Call, Mat Kirkby and James Lucas – *WINNER*
Crisis Hotline: Veterans Press 1, Ellen Goosenberg Kent and Dana Perry – *WINNER*
Joanna, Aneta Kopacz
Our Curse, Tomasz Sliwinski and Maciej Slesicki
The Reaper (La Parka), Gabriel Serra Arguello
White Earth, J. Christian Jensen
(photo from The Academy)
Sources: BuzzFeed, Forbes and The Wrap
Film and Television87th Academy Awards, Alejandro G. Inarritu, American Sniper, Big Hero 6, Birdman, Boyhood, Captain America: The Winter Soldier, Dawn of the Planet of the Apes, Eddie Redmayne, Film, Foxcatcher, Gone Girl, Guardians of the Galaxy, Ida, Interstellar, Into the Woods, J.K. Simmons, Julianne Moore, Movies, Mr. Turner, Neil Patrick Harris, Patricia Arquette, Selma, Still Alice, The Academy Awards, The Grand Budapest Hotel, The Hobbit, The Imitation Game, The Theory of Everything, Two Days One Night, Unbroken, Whiplash, Wild
Screen Actors Guild Awards – Complete Winners List
January 25, 2015 January 25, 2015 yaunnaraeLeave a comment
Award season is in full swing and we are on the road to the Oscars! Movie and television buffs have been watching nominations closely as it has been another incredible year in the movie and TV world. The Golden Globes saw some surprise winners so it will be interesting to follow the Screen Actors Guild (SAG) Award results tonight.
Follow along with us live:
Theatrical Motion Pictures
Steve Carell – Foxcatcher (Sony Pictures Classics)
Benedict Cumberbatch – The Imitation Game (The Weinstein Company)
Jake Gyllenhaal – Nightcrawler (Open Road Films)
Michael Keaton – Birdman (Fox Searchlight Pictures)
Eddie Redmayne – The Theory of Everything (Focus Features) *WINNER*
Jennifer Aniston – Cake (Cinelou Films)
Felicity Jones – The Theory of Everything (Focus Features)
Julianne Moore – Still Alice (Sony Pictures Classics) *WINNER*
Rosamund Pike – Gone Girl (20th Century Fox)
Reesa Witherspoon – Wild (Fox Searchlight Pictures)
Robert Duvall – The Judge (Warner Bros. Pictures)
Ethan Hawke – Boyhood (IFC Films)
Edward Norton – Birdman (Fox Searchlight Pictures)
Mark Ruffalo – Foxcatcher (Sony Pictures Classics)
J.K. Simmons – Whiplash (Sony Pictures Classics) *WINNER*
Patrica Arquette – Boyhood (IFC Films) *WINNER*
Keira Knightley – The Imitation Game (The Weinstein Company)
Emma Stone – Birdman (Fox Searchlight Pictures)
Meryl Streep – Into the Woods (Walt Disney Studios Motion Pictures)
Naomi Watts – St. Vincent (The Weinstein Company)
Birdman *WINNER*
Adrien Brody – Houdini (History)
Benedict Cumberbatch – Sherlock: His Last Vow (PBS)
Richard Jenkins – Olive Kitteridge (HBO)
Mark Ruffalo – The Normal Heart (HBO) *WINNER*
Billy Bob Thornton – Fargo (FX)
Ellen Burstyn – Flowers in the Attic (Lifetime)
Maggie Gyllenhaal – The Honorable Woman (SundanceTV)
Frances McDormand – Olive Kitteridge (HBO) *WINNER*
Julia Roberts – The Normal Heart (HBO)
Cicley Tyson – The Trip to Bountiful (Lifetime)
Steve Buscemi – Boardwalk Empire (HBO)
Peter Dinklage – Game of Thrones (HBO)
Woody Harrelson – True Detective (HBO)
Matthew McConaughey – True Detective (HBO)
Kevin Spacey – House of Cards (Netflix) *WINNER*
Outstanding Performance by a Female Actor in a Drama Series (6 nominees)
Claire Danes – Homeland (Showtime)
Viola Davis – How to Get Away With Murder (ABC) *WINNER*
Julianna Margulies – The Good Wife (CBS)
Tatiana Maslany – Orphan Black (BBC America)
Maggie Smith – Downton Abbey (PBS)
Robin Wright – House of Cards (Netflix)
Ty Burrell – Modern Family (ABC)
Louis C.K. – Louie (FX)
William H. Macy – Shameless (Showtime) *WINNER*
Jim Parsons – The Big Bang Theory (CBS)
Eric Stonestreet – Modern Family (ABC)
Uzo Aduba – Orange is The New Black (Netflix) *WINNER*
Julie Bowen – Modern Family (ABC)
Edie Falco – Nurse Jackie (Showtime)
Julia Louis-Dreyfus – Veep (HBO)
Amy Poehler – Parks and Recreation (NBC)
Downton Abbey (PBS) *WINNER*
House of Cards (Netflix)
Brooklyn Nine-Nine (FOX)
Orange is the New Black (Netflix) *WINNER*
Veep (HBO)
(photo via The Hollywood Reporter)
SAG AWARDS® HONORS FOR STUNT ENSEMBLES
Fury (Columbia Pictures)
Get On Up (Universal Pictures)
The Hobbit: The Battle of the Five Armies (Warner Bros. Pictures)
Unbroken (Universal Pictures) *WINNER*
X-Men: Days of Future Past (20th Century Fox)
Outstanding Action Performance by a Stunt Ensemble in a Comedy or Drama Series
24: Live Another Day (FOX)
Game of Thrones (HBO) *WINNER*
The Walking Dead (AMC)
Life Achievement Award
Screen Actors Guild 51st Annual Life Achievement Award
Film and Television2015 Award Season, Birdman, Boyhood, Film, Foxcatcher, Game of Thrones, House of Cards, Into the Woods, Movies, Orange is the New Black, Screen Actors Guild, Screen Actors Guild Awards, St. Vincent, Television, The Grand Budapest Hotel, The Imitation Game, The Normal Heart, The Theory of Everything, Whiplash
Movie Exclusive – First Look at Disney's "Into the Woods"
September 27, 2013 yaunnaraeLeave a comment
Those familiar with the world of Broadway and musical theater are probably aware that the classic musical Into the Woods is getting adapted into a major motion picture. Well, Entertainment Weekly recently released an exclusive image, giving us our first official look at the film.
This exciting new image feature actress Meryl Streep as her character, The Witch. It also gives us a detailed look at the stylized world that is being formed by director Rob Marshall and his creative teams.
For those who may be unfamiliar with the story, Into the Woods follows a Baker and his wife, who are on a journey to try and find the witch to get her to lift a family curse she has cast on them. On their journey, they cross paths with several quirky fairytale characters, including Rapunzel, Cinderella, and Little Red Riding Hood.
Into the Woods also stars Anna Kendrick, Chris Pine, Johnny Depp, Emily Blunt, James Corden, Billy Magnussen, Tracey Ullman, Christine Baranski, Lilla Crawford, and Daniel Huttlestone. Production officially started on the film this week in the UK, but it is not set to hit theaters until next Christmas. Be sure to check back in for more exclusives as production continues!
Books, Broadway, Film and Television, MusicAnna Kendrick, Billy Magnussen, Books, Broadway, Casting Exclusive, Casting News, Casting Scoop, Chris Pine, Christine Baranski, Daniel Huttlestone, David Krane, Disney, Emily Blunt, Entertainment Weekly, Film, First Look, IMDb, IMDbPro, Into the Woods, James Corden, James Lapine, John DeLuca, Johnny Depp, Lilla Crawford, Meryl Streep, Movie Exclusive, Movie Musical, Movie News, Movies, Music, Pitch Perfect, Rob Marshall, Stephen Sondheim, Television, The Last Five Years, Tracey Ullman, Tracy Ullman
Casting Rumor – Anna Kendrick Could Journey "Into the Woods" as Cinderella
June 24, 2013 June 24, 2013 yaunnaraeLeave a comment
Casting rumors circulating actress Anna Kendrick are stating she is in talks to play Ciinderella in the Disney adaptation of the hit Broadway musical, Into the Woods. The actress revealed her vocal talents last year in Pitch Perfect and is currently working on an adaptation of another musical, The Last Five Years.
This project already has a great cast lined up with Meryl Streep, Johnny Depp, Jake Gyllenhaal, Chris Pine, Emily Blunt, James Corden, Tracy Ullman and Christine Baranski all in various stages of negotiations. Corden will be playing the Baker, Ullman will be playing Jack the Giant Killer's mother, and Baranski will be playing Cinderella's Stepmother.
Into the Woods is a very unique, interesting, and darkly comedic musical. The story follows a Baker and his wife, who are on a journey to try and find the witch to get her to lift a family curse she has cast on them. On their journey, they cross paths with several quirky fairytale characters, including Rapunzel, Cinderella, and Little Red Riding Hood.
Cinderella's situation is a little different in this musical as she is already married to the Prince (Pine), but it turns out he is quite vain. However, she is still trying to find herself and her place in the world.
Rod Marshall will be directing Disney's adaptation of this popular musical. Plus, John DeLuca is producing, James Lapine wrote the screenplay, and David Krane will be working on the music for the highly anticipated movie musical.
Will you be interested in seeing Into the Woods as a movie musical? Do you think Kendrick will be right for the role of Cinderella? Be sure to check in for more news about Into the Woods as production development and casting continues!
Sources: The Hollywood Reporter, MovieFone, and IMDbPro
Books, Broadway, Film and Television, MusicAnna Kendrick, Books, Broadway, Casting Exclusive, Casting News, Casting Rumor, Casting Scoop, Chris Pine, Christine Baranski, David Krane, Disney, Emily Blunt, Film, IMDb, IMDbPro, Into the Woods, Jake Gyllenhaal, James Corden, James Lapine, Jeremy Jordan, John DeLuca, Johnny Depp, Meryl Streep, Movie Exclusive, Movie Musical, Movie News, Moviefone, Movies, Music, Pitch Perfect, Rob Marshall, Stephen Sondheim, Television, The Hollywood Reporter, The Last Five Years, Tracy Ullman
Casting Scoop – Actress Emily Blunt in Talks to Join "Into the Woods"
May 17, 2013 June 24, 2013 yaunnaraeLeave a comment
Just a few days after casting rumors stating Chris Pine and Jake Gyllenhaal may be joining the Into the Woods adaptation began to circulate, more news has come to light.
The Hollywood Reporter has shared that actress Emily Blunt is also in talks to join the Rob Marshall-directed movie musical. If Blunt joins the project she will be playing the Baker's Wife, who is "placed under a spell of barrenness by her sorceress neighbor." However, when she is freed from the power of the spell, she suddenly becomes pregnant.
Most of the parts in this musical are fairly demanding when it comes to singing. This should not be an issue for Blunt if she is officially cast in the role as she does have some experience in singing.
As previously reported, Meryl Streep and Johnny Deep have both already signed on to the project as the vain and evil witch and the wolf, respectively. Although the deals for Pine and Gyllenhaal to join the cast have not officially started, they have gone through an audition process.
John DeLuca is producing, James Lapine wrote the screenplay, and David Krane will be working on the music for the anticipated adaptation.
What do you think of these potential casting choices? Will you be interested in seeing Into the Woods as a movie musical? Be sure to check in for more news about Into the Woods as early production development continues!
Books, Broadway, Film and Television, MusicBooks, Broadway, Casting Exclusive, Casting News, Casting Scoop, Chris Pine, David Krane, Emily Blunt, Film, Into the Woods, Jake Gyllenhaal, James Lapine, John DeLuca, Johnny Depp, Meryl Streep, Movie Exclusive, Movie Musical, Movie News, Movies, Music, Rob Marshall, Stephen Sondheim, Television, The Hollywood Reporter
Casting Scoop – Chris Pine and Jake Gyllenhaal in Talks to Join "Into the Woods" Adaptation
Broadway fans maybe intrigued and excited to hear that production and casting is picking up for the movie adaptation of the classic fairytale musical Into the Woods.
The Hollywood Reporter has shared that actors Chris Pine and Jake Gyllenhaal are in talks to join the cast of the Rob Marshall-directed movie musical. If Pine and Gyllenhaal sign on, they will be playing Cinderella's Prince and Rapunzel's Prince. These characters are also brothers who are both very self-absorbed and snobbish.
For those of you unfamiliar with the musical, it follows a Baker and his wife who go on a journey to find the witch who cast a spell on them and try to lift a family curse. On their journey, they cross paths with several quirky and interesting characters, including Rapunzel, Cinderella and Little Red Riding Hood.
Meryl Streep and Johnny Deep have both already signed on to the project as the vain and evil witch and the wolf, respectively. Although the deals for Pine and Gyllenhaal to join the cast have not officially started, they have auditioned for Marshall. If these deals are made official, both actors will be making their movie musical debut.
John DeLuca is producing and James Lapine wrote the screenplay for the anticipated adaptation. The original Tony-winning score is by Stephen Sondheim. However, David Krane will be working on the music for the film. Even though there is currently no release date set, the production is considering starting in the fall.
Are you a fan of the musical Into the Woods? Are you looking forward to seeing a movie version of this classic show? What do you think of these potential casting choices?
Sources: The Hollywood Reporter and NextMovie.com
Books, Broadway, Film and Television, MusicBooks, Broadway, Casting Exclusive, Casting News, Casting Scoop, Chris Pine, David Krane, Film, Into the Woods, Jake Gyllenhaal, James Lapine, John DeLuca, Johnny Depp, Meryl Streep, Movie Exclusive, Movie Musical, Movie News, Movies, Music, NextMovie.com, Rob Marshall, Stephen Sondheim, Television, The Hollywood Reporter


Flipkart, the biggest online e-commerce website in India has launched a tablet, Flipkart Digiflip Pro XT 712 in India. Flipkart has launched tablet under DigiFlip brand. Digiflip Pro XT 712 is launched in India for Rs. 9,999. It will be sold exclusively on Flipkart.
Digiflip XT 712 features a 7 inch HD IPS Display with 1280×800 pixel resolution. It runs on 1.3 GHz quad core MediaTek MTK 8382 Processor with 1GB RAM. It has 16 GB internal memory which can be expanded upto 32GB using MicroSD Card.
Digiflip XT 712 comes with 5 megapixel Autofocus rear camera with LED Flash. It also has 2 megapixel front camera. It is a dual sim device with dual standby support. It also supports voice calling.
Digiflip XT 712 has connectivity options like 3G, GPRS/EDGE, Wi-Fi, GPS/AGPS, Bluetooth 4.0, WLAN, USB OTG and Micro-USB. It has 3,000 mAh battery which gives 8 hrs of talktime.
Flipkart Digiflip XT 712 comes in black, white, orange, red, and green colors. It is priced at Rs. 9,999 and will sold exclusively on Flipkart.
Lenovo Phab 2 Plus vs Xiaomi Mi Max: Which Gulliver Wins the Race?


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Riozinho es un municipio brasileño del estado de Rio Grande do Sul.

Se encuentra ubicado a una latitud de 29º38'28" Sur y una longitud de 50º27'09" Oeste, estando a una altura de 90 metros sobre el nivel del mar. Su población estimada para el año 2004 era de 4.421 habitantes.

Ocupa una superficie de 236,95 km².

Localidades de Río Grande del Sur

redpajama_set_name: RedPajamaWikipedia


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One mom made Cornerstone Creek development for disabled adults a reality https://urban-works.com/wp-content/uploads/2017/06/170617-Star-Tribune-Cornerstone-Creek.jpg 2000 1517 UrbanWorks Architecture UrbanWorks Architecture https://urban-works.com/wp-content/uploads/2017/06/170617-Star-Tribune-Cornerstone-Creek.jpg June 17, 2017 June 21, 2017
One mom made Cornerstone Creek development for disabled adults a reality
via Star Tribune "The inspiration for Linda Bialick's first — and last — development project was born decades before the first bulldozer arrived on the job site. Thirty years ago, after her daughter was born with Down syndrome, the stay-at-home mom began to realize that children with developmental disabilities didn't have the same educational, social…
New Cornerstone Creek apartments may be first of their kind https://urban-works.com/wp-content/uploads/2017/06/170616-Finance-and-Commerce-Cornerstone-Creek.jpg 620 330 UrbanWorks Architecture UrbanWorks Architecture https://urban-works.com/wp-content/uploads/2017/06/170616-Finance-and-Commerce-Cornerstone-Creek.jpg June 16, 2017 June 16, 2017
New Cornerstone Creek apartments may be first of their kind
via Finance & Commerce "Earlier this year, Jewish Housing and Programming members and a nonprofit co-developer opened an apartment complex that they believe is the first independent housing of its kind for adults with developmental disabilities. The 45-unit Cornerstone Creek complex…in Golden Valley, was designed with a focus on "creating community," said lead architect David…
J-HAP Changes Housing for Developmentally Disabled Adults https://urban-works.com/wp-content/uploads/2017/05/160203-Cornerstone-Creek-Exterior-Model-South-Elevation.jpg 4000 2263 UrbanWorks Architecture UrbanWorks Architecture https://urban-works.com/wp-content/uploads/2017/05/160203-Cornerstone-Creek-Exterior-Model-South-Elevation.jpg May 9, 2017 May 11, 2017
J-HAP Changes Housing for Developmentally Disabled Adults
via TCJewfolk.com "What's inside the four-month-old building…is a community and agency that is unique to the Twin Cities – and possibly the country." Cornerstone Creek is an affordable housing building that's the home to Jewish Housing and Programming (J-HAP), the 10-year-old agency that is part of the team that opened the 45-unit apartment building in January…
Artspace Hastings River Lofts "Hard Hat Tour" Featured in Video https://urban-works.com/wp-content/uploads/2017/05/Artspace-Hastings-River-Lofts-Hard-Hat-Tour.jpg 2048 1536 UrbanWorks Architecture UrbanWorks Architecture https://urban-works.com/wp-content/uploads/2017/05/Artspace-Hastings-River-Lofts-Hard-Hat-Tour.jpg May 4, 2017 May 9, 2017
Artspace Hastings River Lofts "Hard Hat Tour" Featured in Video
via Hastings Community TV Artspace, along with Loeffler Construction and Consulting, gave a "hard hat tour" of Artspace Hastings River Lofts to show the construction progress, spectacular views, and a sense of what it will be like for future residents. Hastings Community TV documented the tour and included floor plans, unit renderings, and other useful information in…
Sustainable: The business case for going green https://urban-works.com/wp-content/uploads/2017/02/160711-Cameron.jpg 5042 2517 UrbanWorks Architecture UrbanWorks Architecture https://urban-works.com/wp-content/uploads/2017/02/160711-Cameron.jpg May 3, 2016 March 3, 2017
Sustainable: The business case for going green
via Finance & Commerce "When the local chapter of the United States Green Building Council launched its IMPACT conference four years ago, it drew about 120 people interested in the intersection of design, construction and sustainability. Last year more than 220 people attended, and more are expected at this year's conference Thursday at the St. Paul RiverCentre. Other…
Inside View: John Seppanen, UrbanWorks Architecture https://urban-works.com/wp-content/themes/engic/images/empty/thumbnail.jpg 150 150 UrbanWorks Architecture UrbanWorks Architecture https://urban-works.com/wp-content/themes/engic/images/empty/thumbnail.jpg September 19, 2013 March 3, 2017
Inside View: John Seppanen, UrbanWorks Architecture
via Star Tribune UrbanWorks Architecture has hired John Seppanen, a specialist in sustainable design innovation, as senior project architect. Read More
Minneapolis' UrbanWorks Architecture hires senior project architect https://urban-works.com/wp-content/themes/engic/images/empty/thumbnail.jpg 150 150 UrbanWorks Architecture UrbanWorks Architecture https://urban-works.com/wp-content/themes/engic/images/empty/thumbnail.jpg August 22, 2013 March 3, 2017
Minneapolis' UrbanWorks Architecture hires senior project architect
via REJournals.com John Seppanen has joined UrbanWorks Architecture as senior project architect. Read More
Schafer Richardson to build seven-story multifamily housing property in Minneapolis
Aeon opens $54.3M affordable housing development
Schafer Richardson's Viridum apartment development earns LEED Silver Certification
Understanding Evidence-Based and Trauma-Informed Design Principles
Ryan Cos. breaks ground on $60M senior living center in Woodbury
Affordable Housing Apartments Architecture award Awards Blog Bloomington Des Moines Dinkytown Education Housing interior design LEED Market Rate Housing Micros Minneapolis Mixed-use Multifamily New Construction nonprofit North Loop Office Parking Ramp Press Rehab Saint Paul senior Senior Housing Student Housing Supportive Housing Sustainable Trauma Informed Design Volunteer West Loop Woodbury Workforce Housing


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District Ambala is stated to be one of the prominent districts of Haryana with historical significance. Ambala was discovered during the reign of the British by C. Rodgers and A.C. Cunningham and afterwards by B.B. Lal and others. The most basic literary mention of the region consisting of District Ambala in 'Taittiriya Aranayaka' talks about Turghna as the neighboring area to the North side of Kurukshetra.
Founding of Ambala District
It is construed that District Ambala was founded during the 14th Century A.D. by Amba Rajput. One more historic description states that 'Ambala' name is derived from 'Amba Wala' or the mango groves that used to exist in the immediate neighborhood of the region. Yet another story states that Ambala has got its name from Goddess Bhawani Amba whose shrine is there in the present Ambala city.
History of the Powers that Prevailed in Ambala
The initial residents of District Ambala were some primeval people of lower Paleolithic Age using stone tools. These tools could be found at many places in Ambala such as Tarlokpur etc. Regrettably, Ambala has not given in any site related to pre Harappan and established Harappan times. The presence of Aryans in the district is also supported by various evidences including the gray ware pottery.
The Pandavas as well as their descendants also included District Ambala in their kingdom. The different pronouncements of Ashoka, particularly the stupas at Chaneti and Singh and the Topara edicts, link the district to the Mauryas. Kushan bricks have also been found in some areas which give good reason for the fact that Ambala was once included in the empire of Kushanas. The evidence is held up by the presence of silver coins and inscriptions on Mehrauli Pillar.
The region Ambala constituted an important part of almost all major ruling dynasties in the country. Some foreign stories, specifically by Chinese pilgrim Huen Tsang, states that the district was also under the influence of Buddhism. After being invaded by Mohammed Ghaznavi, it was brought under the control of Charuhaus.
The testimony to this fact lies in the Topara Pillar. Finally, after the defeat of Prithviraj Chauhan in the 2nd battle of Terrain in 1192, the Muslims took over the district. The district remained an important center of sacred pilgrimage from 9th to 12th Century. The findings of the images of lords at various places suggest the existence of magnificent temples that were possibly destroyed during the invasions by Muslims.
Under the rule of Muslims, Ambala was a part of 'Kutab-Bin-Aibak' kingdom. The area was also invaded by Timur. Bahlol Lodhi, the then Governor of Punjab, brought the area under his control in 1450 till the invasion of Babar in 1526. After the death of Aurangzeb, various forces and the political situation grew up to be in opposition of the kingdom. One of the disciples of Guru Gobind Singh, Banda Bahadur, launched a brutal attack on Ambala in 1709-10.
However, he lost to the Mughals in 1710. After him, a Mughal official named Khidmat administered Ambala till the year 1739. After the invasion of Nadir Shah, there followed a dark period and Ambala was divided into small principalities. After slaying the Abdalis Governor, the territory was possessed by the agitated Sikhs in 1763.
In a nutshell, Ambala district was crammed with political turmoil and activities during the medieval age.
Comments / Discussion Board - History of Ambala
Richa from Faridabad 1525 Days ago
i want to know about the historical monuments in ambala?


So what is a township? In the 1970's the South African government began moving Blacks away from white areas and into concentrated locations called townships. The word "apartheid" literally means "apart" in Afrikaans. In other words, segregation. Many of these townships were located in a new "independent country," called Bophuthatswana (there were others as well). Picture reservations for Native Americans in the U.S. and you get the idea and intent. Although apartheid ended, the physical relocations remained an accomplished fact. Most of the schools I will be visiting on this trip are located in townships. Part of the current struggle in South Africa is to undo the social and economical damage of apartheid while preserving and strengthening these communities.
As Malebye and I walked through the township he recounted some of the hardships he endured under apartheid, such as being forced to carry a passbook at all times. To travel to another town, even for work, you had to get permission from the authorities. They did not want people leaving the townships freely. To be caught without an authorized passbook meant a beating, or jail, or both. It is important to remember that apartheid only ended 20 years ago. Any adult you meet in South Africa grew up under apartheid. Also important to consider, most Black teachers in South Africa were themselves educated under apartheid.
Today Malebye surprises me by saying that in some ways education in Bophutatswana under apartheid was superior to what is now available in many townships. While there was a lack of resources, there was also greater educational independence and a greater sense of unity and purpose. Now the lack of resources is still an issue, but all schools must follow the same national curriculum and all students compete on the same national exams. Picture students studying science in a township, who have no textbooks and no lab equipment, taught by teachers who may have themselves received an inferior education, and yet these students must compete against schools with resources comparable to Ithaca high school.
A final note: because of the ravages of HIV/AIDS more than 70% of Black South Africans are under the age of 35. South Africa is rapidly losing the "veterans" of the fight against apartheid. Many of the youth currently growing up in townships do not feel the motivation of a unified struggle. They see poverty, crime and HIV/AIDS as simply the conditions of existence, not the consequences of injustice. For many of them there is no light at the end of the tunnel, there is just the tunnel.


A new year can be a great time for change—clearing out clutter from your living space, planning goals for the year, etc. It can also be a wonderful time to clear out what we have been carrying for too long: the burdens that weigh on our hearts caused by not forgiving others and not forgiving ourselves. Expand your heart with forgiveness and gratitude and experience your life as joyous and abundant.
On Saturday, January 2, 2010, we will be hosting a Day of Forgiveness and Gratitude at the Center for Creative Learning, lasting from 9 am to 4 pm. Learn more about the day.
We hope you can join us for this retreat day. Past participants have wonderful things to say about the day!
Previous post: Day of Fine Tuning a Great Success!


Na £120million wey Real Madrid want for Gareth Bale, e worth am?
The reports wey we dey hear from Mirror na say Gareth Bale wan leave spain as e wan return back to the Premier League, as e dey fight for game time.
Manchester United never table money for the Welshman but we hear say Ed Woodward don dey yarn with Madrid presido. The money wey Real Madrid want for am na £120million. You feel say e worth am?


My destination was The Killing Fields, a lasting legacy of the auto-genocide planned and executed by the Khmer Rouge and its psychotic leader Pol Pot.
American author Antonio Graceffo traverses Cambodia to reveal Bokator in Khun Khmer: Cambodian Martial Arts Diary.
Has Vietnam Lost the Struggle for Freedom?
A "no win" policy was pursued to allow the communists (nationalists) to take Vietnam in its entirety to form a unified state. The motive of "no-win" war policy was to force Vietnam seek credit and economic development via international finance.
Twenty days after Ann Marie was born, her mother passed away from AIDS-related complications. There is a high probability that Ann Marie is HIV positive. It is hoped that she has relatives who may come to visit her one day, but this is not a certainty because none of her relatives know where she is.
Forget the black belt tests. How do you grade yourself? After all, the only grading that matters is the one you give yourself.
Linguist and author Antonio Graceffo uses ALG concepts to learn Khmer language through picture stories. The pictures and an English retelling of the story create a context to make the foreign language input comprehensible. There is no actual translation, but there is contextualization.
Studying a foreign language through the medium of another foreign language appears to have a number of benefits.
Golden Leaf wonderfully depicts the struggles and subsequent victories of a remarkable human being, and will inspire readers because it reaches deep into our souls.
There were many things I really wanted to hear from the students. What did they love most about Cambodia? Where in the world did they want to visit? What were their ambitions?
In the wet season of 2008, David Calleja presented A Garbage Diet. This provided an insight into Steung Meanchey, home to hundreds of residents living on a rubbish dump on the outskirts of Phnom Penh, Cambodia. For his second visit in January 2009 during the dry season, David joins members of the recently formed NGO named CHOICE, speaks with children and captures images of the site marked for closure, leaving residents facing an uncertain future.
While S-21 is the most infamous of Khmer Rouge prisons, the KR maintained more than one hundred other prisons in Cambodia, of which there is only one survivor.
Van Nat was taken to S 21, where he was also tortured, and where he was still not informed of charged against him. One-day, guards took him from his cell and locked him in a workshop, where he was instructed to paint a portrait of Pol Pot.
The history of the archives was a fascinating tour through the history of political intrigue which plagues Cambodia's past.


It is my distinct pleasure to welcome you to the Montessori School of Manhattan. I hope you are able to easily find the information that you are looking for within our website.
Located in the heart of the Financial District, surrounded by sunny parks, and the breathtaking South Street Seaport, at MSM you will discover a warm, welcoming community. Our school environment and curriculum provide children ages 2 to 6 with a life-long love of learning. Our Montessori teachers are certified in using Dr. Montessori's methods and materials to lovingly guide each child in developing unique abilities within a carefully planned curriculum. Our goal is to provide the learning experiences that allow children to develop the skills to become successful learners within the classroom, and more importantly, to develop self-confidence, independence, compassion, and the sense of responsibility to become successful members of society long after their time at MSM is over.
First-time visitors to our campuses are invariably impressed with the excitement, self-discipline and self-sufficiency of even the youngest child. Using didactic learning materials designed by Dr. Montessori to be responsive to a wide range of interests and skills, children are encouraged to explore a world of ideas, information, and creativity. The Montessori curriculum stresses an interdisciplinary approach to all learning. Students discover a natural excitement for new concepts and ideas within an atmosphere of grace, courtesy and mutual respect.
Supported by one-on-one guidance from their teachers, students work both independently and in small groups with other children. By providing an environment that specifically addresses each child's individual needs, students at MSM enjoy an educational experience that enhances self-esteem, fosters the social skills to solve problems and build friendships, and support the ever-increasing curiosity about the world in which they live.
Parents and community resources contribute to, and further enrich the learning partnership. Parents are encouraged to attend our workshops, participate in the Parents' Association, observe in their child's classroom, volunteer to assist with class projects and field trips, and participate in school-wide events.
At MSM, we have the unique opportunity to provide young children with hands-on learning experiences that create excitement, enrichment and unending discovery. I invite you to further explore MSM and all that it has to offer by attending an Open House, or by applying to one of our many programs.


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Check Out DJ Diplo's Thoughts About Nigerian Music
American producer and DJ, Thomas Wesley Pentz better known by his stage name Diplo was in Nigeria for Gidi Fest a few months ago and he's got a lot of great things to say about the Nigerian music scene.
According to him, while speaking about his experience in Nigeria during an interview with GQ, the DJ said Nigerian musicians have had a huge impact on music in the last ten years.
The next day he performed at a private party on a rooftop and Diplo, who was impressed by the turn out of things said, "I said to [Major Lazer MC] Walshy Fire, Man, Nigeria is where you either live or die as a DJ. This is like the DJ Olympics."
He went further to describe Nigeria's afro-pop movement as the next best thing to happen to the world of music, naming artistes like Davido, Wizkid and Mr Eazi as being among the Nigerian musicians taking over the world with this new Afro-pop movement.
"Nigeria has this huge diaspora, like Jamaica. Nigerians live everywhere: England, L.A., New York. Nigerians have had a huge impact on music in the last ten years. Like the UK funky stuff that ended up becoming "One Dance" by Drake. And then, over the last three or four years, Nigerians have been taking over with this new Afro-pop movement.
"The music scene is amazing because they have pop stations—you're gonna hear Bieber and Katy Perry. Then they have all the hip-hop and R&B—"Bad and Boujee" was a hit in Lagos before America.
"Then they have all the Nigerian stuff—the Afro-pop like Davido, Wizkid, Mr Eazi. And then they also have legacy stuff, like Fela Kuti and Femi Kuti, palm-wine music, and highlife," he noted.
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'Tis the season to stock the bar. While it's a time for tradition, it's also a time for surprises. So if you're looking to spice up the table with a few new twists as well, I hope you find inspiration in the list below.


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è un film d'animazione del 1997 diretto da Takuya Satō.

L'anime rielabora sotto forma di lungometraggio i 4 OAV precedenti della serie Armitage III.

Esiste un sequel, Armitage III: Dual-Matrix ambientato alcuni anni dopo la prima storia.

Trama
In un futuro in cui Marte è sul punto di unirsi alla Terra per formare un'unica colonia umana, prende avvio una serie di delitti piuttosto macabri che scuote l'opinione pubblica: vengono di fatto ritrovati corpi di donne orrendamente mutilate che rivelano all'interno parti robotiche. Si viene in questo modo ad ipotizzare che appartengano ad una nuova specie di cyborg.

Questi atti di violenza alimentano quindi l'odio degli uomini verso le macchine, ormai giunte ad imitarli perfettamente e quindi a prenderne il posto nei luoghi di lavoro costringendoli alla povertà. Ma sulle tracce del maniaco si mettono subito al lavoro i due detective Armitage e Ross. Entrambi nascondono segreti sulle proprie esperienze passate con i robot e sembrano mossi da questioni personali. Incontreranno infine l'essere che si nasconde dietro questi crimini, ma a quel punto scopriranno una cospirazione su scala molto più ampia di quel che avevano immaginato.

Personaggi
Naomi Armitage
Protagonista dell'opera, è una ragazza piuttosto vivace, ma molto accurata nel proprio lavoro di detective. Si interessa agli omicidi quando scopre che le ragazze uccise in realtà sono come lei: appartengono cioè alla terza generazione di robot marziani. Si innamora durante la missione del suo compagno, Ross, a cui infine è costretta a confessare il proprio segreto.
Ross Sylibus
Con un passato duro alle spalle, dopo che la sua compagna è stata uccisa da un androide, si trasferisce su Marte e affianca Armitage nella ricerca del serial killer di robot. È combattuto non sapendo con certezza cosa provare nei confronti dei cyborg, visto ciò che gli è capitato in passato, ma alla fine si innamora di Armitage.

Colonna sonora
Dawn In Mars
Armitage Main Theme
Second Type
Chase
The Killer
A City Without Sunshine
Phantom World - Maureen Davis
Cyber Transmission
Armitage The Short
A Tear Of A Cyborg
Bioraid
D'Anclaude
A Crystal Drop
More Aggressive
Cyber Battle
Silent War
Multi-Matrix (Ending Theme)
Here With You - Linda Hennrick
Cheat! Cheat! - Linda Hennrick

Collegamenti esterni

Armitage III
Film d'animazione giapponesi
Film di fantascienza


Hypoxia is a typical character of locally advanced solid tumours. The transcription factor hypoxia-inducible factor 1α (HIF-1α) is the main regulator under the hypoxic environment. HIF-1α regulates various genes to enhance tumour progression, angiogenesis, and metastasis. Sphingosine kinase 1 (SPHK-1) is a modulator of HIF-1α.
To investigate the molecular mechanisms of pristimerin in association with SPHK-1 pathways in hypoxic PC-3 cancer cells. Vascular endothelial growth factor (VEGF) production, cell cycles, and SPHK-1 activity were measured, and western blotting, an MTT assay, and an RNA interference assay were performed.
Pristimerin inhibited HIF-1α accumulation in a concentration- and-time-dependent manner in hypoxic PC-3 cells. Pristimerin suppressed the expression of HIF-1α by inhibiting SPHK-1. Moreover, inhibiting SPHK-1 with a sphingosine kinase inhibitor enhanced the suppression of HIF-1α, phosphorylation AKT, and glycogen synthase kinase-3β (GSK-3β) by pristimerin under hypoxia. Furthermore, a reactive oxygen species (ROS) scavenger enhanced the inhibition of HIF-1α and SPHK-1 by pristimerin.
Taken together, these findings suggest that pristimerin can exert an anti-cancer activity by inhibiting HIF-1α through the SPHK-1 pathway.
Hypoxia is a common characteristic of locally advanced solid tumours  and up to 50–60 % of solid tumours include areas of hypoxic tissues . The hypoxic tumour contributes to aggressive and metastatic cancer phenotypes that are associated with resistance to radiation therapy, chemotherapy, and a poor treatment outcome [3, 4].
The hypoxia inducible factor-1 (HIF-1) is a transcription factor and also a key factor that maintains oxygen homeostasis in mammalian cells . HIF-1 is a heterodimer consisting of HIF-1α and β subunits . HIF-1α is dominantly expressed under hypoxic conditions, however, it exists in low levels under normoxic conditions . On the contrary, HIF-1β is expressed constitutively . In normoxic conditions, HIF-1α is hydroxylated by a tumour suppressor Von Hippel-Lindau (VHL) protein of the E3 ubiquitination ligase complex. Whereas, under hypoxic conditions, HIF-1α remains unhydroxylated and facilitates several factors, [8–10] such as angiogenesis, tumour proliferation, tumour survival, and glycolysis [11, 12]. Sphingosine-1-phoshate (S1P) is a signaling sphingolipid metabolite and a potent lipid mediator, which regulates progress in tumour cells such as cell growth, proliferation, apoptosis, invasion, angiogenesis, calcium homeostasis, and vascular maturation [13, 14]. S1P precursors generate from sphingosine by sphingosine kinase 1 (SPHK-1), and the generation of S1P precursors triggers either a cell's proliferation or death . SPHK-1 can act as a catalyst for the ATP-dependent phosphorylation of sphingosine, which stimulates a wide array of growth factors, such as PDGF, FGF, EGF, HGF, VEGF, etc. [15–21]. SPHK-1 mRNA is overexpressed in various solid tumours, such as a breast, brain, lung, stomach, colon, kidney, and ovary tumours . Several studies have demonstrated that SPHK-1 controls the level of HIF-1α during hypoxia in cancer cells .
Pristimerin is a naturally occurring triterpenoid quinone methide [24, 25]. Several studies have demonstrated that pristimerin is involved in a variety of multiple biological activities related to anti-inflammatory, anti-oxidant, anti-cancer, anti-malarial, and anti-microbial action [26–28]. Also, pristimerin has shown potent anti-cancer effects, including anti-proliferation, anti-migration, anti-angiogenesis, and apoptosis-inducing activity in various cancer cell lines, including glioma, leukemia, breast, lung, and prostate cancer cell lines [24, 25, 29, 30] by inhibiting NF-kB [29, 31–36]. Recently, Zuo, et al. reported that pristimerin has an inhibitory action on hypoxia-mediated metastasis . Nevertheless, the potential effects and the mechanism of pristimerin in hypoxia-mediated cancers still remain unknown.
Here, we demonstrate that pristimerin inhibits HIF-1α via the SPHK-1 signaling pathway in a prostate cancer cell lines. The results we have yielded provide the mechanism for inhibitory action of HIF-1α and angiogenesis by pristimerin in hypoxic prostate cancer cell lines.
Pristimerin (purity: ≥98 % as determined by HPLC) was purchased from Sigma Aldrich (St Louis, MO, USA).
The human castration-resistant prostate cancer cell lines PC-3 and DU145 cells were preserved in RPMI1640 (Welgene, Daegu, Korea), supplemented with 10 % FBS and 1 % antibiotics (Welgene, Daegu, Korea). The human androgen responsive prostate cancer cell line LNCaP was maintained in RPMI1640, supplemented with 25 % HEPES (Welgene, Daegu, Korea), 10 % FBS and 1 % antibiotics (Welgene, Daegu, Korea). Normoxically conditioned cells were cultured in a 5 % CO2 incubator at 37 °C. The cells cultured under hypoxia were grown in a hypoxic chamber (Forma Scientific, Marietta, OH, USA) containing 1 % oxygen, 5 % carbon dioxide, and 94 % nitrogen at 37 °C.
A colorimetric 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay (Sigma, USA) was used to assess cell viability. Cells (1 × 104 per well) were seeded in 96-well plates (SPL Life Science, Korea) and treated with various concentrations (0, 0.047, 0.094, 0.188, 0.375, 0.75, 1.5, and 3 μM) of pristimerin. After 24 h, 50 μL of MTT reagent (1 mg/mL) was added. After incubation for 1 h, optical density was measured by an ELISA-Reader (Tecan, Switzerland) at a wavelength of 570 nm.
The cells were lysed in RIPA buffer (Cell signaling, USA). The protein extract were separated on SDS–polyacrylamide gels and were electrotransferred to a nitrocellulose membrane (GE healthcare life sciences, UK). The membranes were blocked in 5 % non-fat dry milk and probed with primary antibodies for SPHK-1 (Cell signaling, USA), HIF-1α (Novus Biologicals, USA), AKT (Santa Cruz Biotechnology, Santa Cruz, CA, USA), p-AKT (Santa Cruz Biotechnology, Santa Cruz, CA, USA), GSK-3β (Invitrogen, USA), p-GSK-3β (Cell signaling, USA), VEGF (Santa Cruz Biotechnology, Santa Cruz, CA, USA), PCNA (DAKO, USA), PI3K (Millipore, Germany), and β-actin (Sigma-Aldrich, St, Louis, MO, USA) overnight at 4 °C and HRP-conjugated secondary antibodies. Detection of specific proteins was carried out with an enhanced chemiluminescence (ECL) assay (GE Healthcare Life Sciences, UK).
To measure sphingosine kinase activity, sphingosine kinase activity assay kit (Echelon, Salt Lake City, UT, USA) was used. The Sphingosine kinase activity assay method was previously described in our other study [37, 38]. Protein extracts (30 μg) were reacted in reaction buffers, 100 μM of sphingosine, and 10 μM of ATP, for 1 h at 37 °C, and then to stop the kinase reaction, a luminescence attached ATP detector was added. Lumistar Optima luminometer (BMG LABTECH, Offenburg, Germany) was used to measure kinase activity. All samples were prepared in triplicates and the assay was repeated at least three times.
VEGF ELISA kit (Invitrogen, Carlsbad, CA, USA) was used to assess VEGF levels in pristimerin and/or SKI exposed PC-3 cells. The VEGF production level measurement methods was previously described in our other study . The culture supernatants was added in a 96-well plate, and reacted with dilution buffer and incubation buffer at room temperature for 2 h. The wells were then washed four times with washing buffer, and then biotin conjugate was added to each well at room temperature for 1 h. After washing, the stabilized chromogen was added into each well and reacted for 30 min at room temperature. The density was measured at 450 nm using a microplate reader (Molecular Devices Co., Sunnyvale, CA, USA) after adding 100 μl of the stop solution.
The cell cycle was determined according to the protocol described previously . Cells were fixed with 75 % ethanol and resuspended in PBS with RNase (1 mg/mL) at 37 °C for 1 h and stained with propidium iodide (PI). The stained cells were analyzed for DNA content by FACS Calibur containing Cell-Quest Software (Becton-Dickinson, Heidelberg, Germany).
The siRNA transfection method was previously described in our other study [37, 38]. A polyplus siRNA transfection reagent (Illkirch, France) was used to transfect siRNA for the control or SPHK-1 into PC-3 cells. In brief, siRNA (80 pmol) was mixed with a transfection reagent in serum-free media and reacted for 10 min at room temperature. The siRNA/transfection reagent mixture was added to the cells and incubated for 48 h. The medium was changed before the treatment with pristimerin and/or SKI under hypoxia.
The data showed as means ± S.D. (standard deviation) of three replications each experiment in this study. Analysis of variance (ANOVA) was used to assess the significance of differences between groups. P <0.05 was considered to indicate statistical significance.
To measure whether pristimerin affects cell viability under hypoxic and normoxic conditions, cells were treated with various concentrations of pristimerin in PC-3 cells under hypoxia or normoxia for 24 h. Pristimerin significantly decreased cell viability under hypoxia than it did under normoxia (Fig. 1a). As shown in Fig. 1b and c, pristimerin treatment for 48 h reduced cell growth in hypoxic PC-3 cells. Similar to the 24 h data, pristimerin significantly decreased cell growth under hypoxia more than normoxia.
To examine whether pristimerin inhibits hypoxia-induced HIF-1α, pristimerin was treated into PC-3 cells under hypoxia for 4 h. As shown in Fig. 1d and e, pristimerin decreased HIF-1α abundance. To examine whether hypoxia-induced VEGF secretion is decreased by pristimerin, the VEGF secretion level was measured on a hypoxia-induced PC-3 cell medium, with pristimerin treatment for 24 h. As shown in Fig. 1f, the VEGF secretion level under hypoxia was higher than under normoxia control. Pristimerin reduced the hypoxia-induced VEGF secretion.
To investigate whether pristimerin affects SPHK-1 in PC-3 cells, the cells were incubated under hypoxia for 4 h with 0.5 or 1 μM of pristimerin. Pristimerin at 1 μM reduced SPHK-1 to 55 % under hypoxia compared with the control (Fig. 2a and b). As SPHK-1 is one of the regulators of HIF-1α, the effect of hypoxia was assessed with the HIF-1α expression. Both the SPHK-1 and HIF-1α accumulation reached the peak 4 h after hypoxia exposure and then decreased in a time-dependent manner. The SPHK-1 and HIF-1α expressions were effectively inhibited by pristimerin (Fig. 2c, d and e).
To confirm the involvement of SPHK-1 in the pristimerin-mediated inhibition of HIF-1α during hypoxia, the effects of pristimerin was evaluated by using SPHK-1 siRNA and an SPHK-1 inhibitor, on SPHK-1 activity and the phosphorylation of AKT and GSK-3β. This is because the SPHK-1 dependent stabilization of HIF-1α is known to be mediated by AKT/GSK-3β, downstream of SPHK-1. The phosphorylation of AKT and GSK-3β was induced under hypoxia (Fig. 3a). Pristimerin suppressed the phosphorylation of GSK-3β and AKT in hypoxic PC-3 cells (Fig. 3a). SKI, an SPHK-1 inhibitor, blocked the expression of HIF-1α and the phosphorylation of AKT and GSK-3β (Fig. 3a). The SPHK-1 activity was significantly decreased by pristimerin and SKI (Fig. 3b). Consistently, SPHK-1 siRNA transfection suppressed pristimerin-mediated inhibition of SPHK-1 in PC-3 cells under hypoxia (Fig. 3c and d). As shown in Fig. 4a, we assessed whether pristimerin suppresses hypoxia-induced HIF-1α and SPHK-1 in several prostate cancer cell lines (PC-3, DU145, and LNCaP). Pristimerin inhibited HIF-1α and the phosphorylation of AKT and GSK-3β in all cell lines tested, which is similar to the results from PC-3 cells (Fig. 4a).
To examine whether ROS mediate pristimerin-induced inhibition of HIF-1α and SPHK-1, PC-3 cells were treated with pristimerin or/and NAC. The treatment with either pristimerin or NAC reduced hypoxia-mediated HIF-1α, and SPHK-1 expressions and activity (Fig. 4b and c).
As shown in Fig. 1c, pristimerin significantly reduced VEGF production. To exam the role of SPHK-1 on the secretion of VEGF, an angiogenic factor, PC-3 cells were treated with pristimerin and SKI under hypoxia for 24 h and VEGF levels were then measured by an ELISA and Western blot. VEGF levels elevated significantly in the hypoxia control group while pristimerin and SKI treatment reduced VEGF secretion (Fig. 5a). In addition, combination treatment with pristimerin and SKI significantly diminished VEGF secretion in PC-3 cells under hypoxia (Fig. 5a).
As shown in Fig. 1b and c, pristimerin significantly decreased cell viability under hypoxia as opposed to normoxia and decreased cell proliferation. Therefore, the effect of SKI and pristimerin on cell proliferation during hypoxia was evaluated by FACS analysis and western blotting.
PC-3 cells were treated with SKI and pristimerin for 48 h under hypoxic conditions. Treatment with pristimerin and SKI significantly increased G1-arrest and decreased the expression of G1 regulatory proteins, such as cylinD1 and CDK4, in hypoxic PC-3 cells (Fig. 5b and c). PCNA is essential for DNA replication. The PCNA level under normoxia was similar to that under hypoxia. SKI and pristimerin treatment reduced the PCNA level. Combination treatment with pristimerin and SKI reduced PCNA under hypoxia (Fig. 5c).
Most solid tumours are more aggressive and resistant to chemotherapy or radiation under hypoxic conditions [37, 41]. Hypoxia is a typical characteristic of locally advanced solid tumours . The transcription factor HIF-1α, which targets 60 genes to enhance the tumour progression, angiogenesis, and metastasis, is regarded as the master regulator under the hypoxic environment [12, 43]. Our previous study showed that the accumulation of HIF-1α is mediated by the AKT/GSK-3β pathway, and related to HIF-1α stabilization through the activation of SPHK-1 . SPHK-1 is a decisive regulator of this sphingolipid rheostat and as such, a potent therapeutic target for cancer treatment [45, 46]. Furthermore, the activity and expression of SPHK-1 are significantly induced under hypoxia and by HIF-1α, and thus is a critical therapeutic target through pVHL-dependent proteasomal degradation for cancer treatment [23, 47–49]. Pristimerin, a triterpenoid quinone methide compound, is involved in a variety of activities, which includes anti-inflammatory and anti-cancer action [27, 29–36]. A recent study reported that pristimerin suppressed HIF-1α and hypoxia-induced metastasis in prostate cancer PC-3 cells . However, the mechanisms of the inhibition of hypoxia-induced HIF-1α by pristimerin are not fully comprehended. In this study, pristimerin significantly decreased cell viability under hypoxia more than it did under normoxia, which connotes the potential of pristimerin treatment-resistant cancer cells, given that HIF-1α promotes cancer resistance. Our study showed that SPHK-1 and HIF-1α accumulations began to increase after 30 min of hypoxia exposure in PC-3 prostate cancer cells compared with the normoxia, which is consistent with previous studies [37, 38]. Moreover, the hypoxia-induced HIF-1α accumulation was suppressed in the presence of pristimerin. In addition, we found that pristimerin suppressed hypoxia-induced SPHK-1. To further confirm the involvement of SPHK-1 in pristimerin-mediated inhibition of HIF-1α under hypoxia, we tested the effects of pristimerin on the phosphorylation of AKT and GSK-3β since AKT/GSK-3β is downstream of SPHK-1 and mediates HIF-1α stabilization . Furthermore, co-treatment of pristimerin and SKI suppressed the phosphorylation of AKT and GSK-3β. Likewise, SPHK-1 siRNA transfection suppressed the phosphorylation of AKT and GSK-3β.
Hypoxia leads to an increase in mitochondrial production of ROS,  and ROS production is required for hypoxia-mediated HIF stabilization [51–54]. Several recent studies have shown that SPHK-1 activity and HIF-1α are stimulated by ROS production [44, 55]. In addition, our previous studies showed that N-acetylcysteine (NAC), an ROS scavenger, suppresses HIF-1α by blocking SPHK-1 under hypoxia.
To confirm whether pristimerin suppresses hypoxia-induced HIF-1α accumulation via the inhibition of SPHK-1 and ROS generation in prostate cancer cells, we evaluated the effect of NAC on HIF-1α and SPHK-1 abundance in hypoxic PC-3 cells, treated with pristimerin. The co-treatment of pristimerin with NAC affected HIF-1α and SPHK-1 abundance.
PI3K is necessary for cell growth and survival, and PI3K can be activated by growth factors binding to cell surface receptor and hypoxia. PI3K induces the accumulation, activation, and stabilization of HIF-1α proteins during hypoxia in cancer cells . To confirm whether pristimerin inhibits hypoxia-induced HIF-1α accumulation by the inhibition of PI3K, PC-3 cells were treated with pristimerin and SKI under normoxic and hypoxic conditions for 24 h. PI3K levels did not change (Additional file 1: Figure S1).
There is evidence that HIF-1α can regulate VEGF secretion in cancer cells [57, 58]. In the present study, the inhibition of SPHK-1 activity using SKI prevented VEGF production in PC-3 cells. Similarly, studies have demonstrated that SPHK-1 plays a critical role in HIF-1α-mediated VEGF secretion under hypoxia [37, 38]. Pristimerin significantly inhibited cell proliferation for 48 h (Fig. 1c). It is well known that SPHK-1 mediates cancer cell proliferation and progression. Thus, to confirm the involvement of SPHK-1 in pristimerin-mediated inhibition of cell proliferation, hypoxic PC-3 cells were treated with SKI and pristimerin for 48 h. Interestingly, SKI and pristimerin co-treatment induced G1 arrest and decreased G1 regulatory factors in hypoxic PC-3 cells.
Our study shows that pristimerin inhibits HIF-1α, SPHK-1 expression or activity, and phospho-AKT/GSK-3β and decreases VEGF production in hypoxic PC-3 cells. These results suggest that pristimerin may inhibit HIF-1α accumulation by inactivation of SPHK-1 including the free radical scavenging effect in PC-3 cells under hypoxia.
This research was supported by Basic Science Research of the National Research Foundation of Korea (NRF) and funded by the Ministry of Science, ICT & Future Planning Program (NRF-2013R1A1A1008431).
All data supporting the findings in this study are included in the manuscript and the supplementary figures. The data in the current study are available from the corresponding author on reasonable request.
HJL conceived and designed the experiments; SOL, JSK and MSL performed the experiment. All authors read and approved the final manuscript.


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Searcy, AR (72143)
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With virus surging, Biden to speed release of COVID vaccines
By RICARDO ALONSO-ZALDIVAR and ZEKE MILLER Associated Press
WASHINGTON (AP) — With COVID-19 surging and vaccinations off to a slow start, President-elect Joe Biden will rapidly release most available vaccine doses to protect more people, his office said Frida.
"The president-elect believes we must accelerate distribution of the vaccine while continuing to ensure the Americans who need it most get it as soon as possible," spokesman T.J. Ducklo said in a statement. Biden "supports releasing available doses immediately, and believes the government should stop holding back vaccine supply so we can get more shots in Americans' arms now."
Biden's plan is not about cutting two-dose vaccines in half, a strategy that top government scientists recommend against. Instead, it would accelerate shipment of first doses and use the levers of government power to provide required second doses in a timely manner.
The Trump administration has been holding back millions of doses of vaccine to guarantee that people can get a second shot, which provides maximum protection against COVID-19. It's seen as a prudent approach, since both the Pfizer-BioNTech and Moderna vaccines require a second shot after the first vaccination.
Health and Human Services Secretary Alex Azar raised questions about Biden's plan, telling a hospital forum on Friday that "we're pushing the system as much as I as secretary believe is ethically and legally appropriate."
But a recent scientific analysis in the journal Annals of Internal Medicine estimated that a "flexible" approach roughly analogous to what Biden is talking about could avert an additional 23% to 29% of COVID-19 cases when compared to the "fixed" strategy the Trump administration is following. That's assuming a steady supply of vaccine.
After a glow of hope when the first vaccines were approved last month, the nation's inoculation campaign has gotten off to a slow start. Of 21.4 million doses distributed, about 5.9 million have been administered, or just under 28%, according to the Centers for Disease Control and Prevention.
Biden has indicated his displeasure with the progress of vaccinations.
"I think the way it's being done now has been very, very sad," he said at his news conference Friday.
The Trump administration's "Operation Warp Speed" has delivered vaccines to the states, he said, "but did not get them from those vials into people's arms," he continued. "And so it is a gigantic logistical concern of how we do that."
Biden says he intends to speed up vaccinations by having the federal government deliver more vaccines and take a stronger role ensuring that they are being administered.
The American Hospital Association estimates that the nation would need to vaccinate 1.8 million people a day, every day, from Jan. 1 to May 31, to reach the goal of having widespread immunity by the summer. That's also called "herd immunity" and would involve vaccinating at least 75% of the population.
Biden has set a goal of administering 100 million shots in the first 100 days of his administration. He's previously said that he and Vice-President elect Kamala Harris have been talking with state and local leaders about meshing the efforts of governments at all levels. Among the specifics: opening up vaccination centers and sending mobile vaccine units to hard-to-reach communities.
The Biden transition office said its experts believe that pushing out available vaccine as fast as possible will not create problems for people needing their second dose. Biden will make broader use of a Cold War-era law to direct private industry to supply materials for vaccine production, should that become necessary, his office said. One-shot vaccines are moving through development.
Former Food and Drug Administration head Mark McClellan said he agrees with Biden's decision, but the increased supply of vaccines has to be coupled with steps to get shots actually administered.
"We're holding back more doses than we really need to," McClellan said in an interview. But "this needs to be combined with steps to increase the administration of vaccines, or it won't make much difference." McClellan, who served under former Republican President George W. Bush, now leads a health policy center at Duke University.
But Azar, President Donald Trump's health secretary, said if vaccine production doesn't increase Biden's approach could lead could lead to "fits and starts" in vaccination. "What we've set up is a system that manages the flow, to maximize the number of first doses, but knowing there will be a second dose available," Azar said, defending the Trump administration's decision.
Biden announced his plan after eight Democratic governors wrote the Trump administration on Friday urging it to do as much.
"The federal government currently has upwards of 50% of currently produced vaccines held back," the governors wrote. "While some of these life-saving vaccines are sitting in Pfizer freezers, our nation is losing 2,661 Americans each day, according to the latest seven-day average. The failure to distribute these doses to states who request them is unconscionable and unacceptable. We demand that the federal government begin distributing these reserved doses to states immediately."
The letter was signed by Govs. Gretchen Whitmer of Michigan, Gavin Newsom of California, Laura Kelly of Kansas, J.B. Pritzker of Illinois, Tim Walz of Minnesota, Andrew Cuomo of New York, Jay Inslee of Washington, and Tony Evers of Wisconsin.
With the winter wave of the pandemic pushing deaths to record levels, and hospitals overwhelmed in cities large and small, some have called on the government to authorize using just one dose of the Pfizer and Moderna vaccines. That would indeed confer a boost of immunity.
However, government scientists including Dr. Anthony Fauci have said the vaccines should continue to be used as prescribed under their emergency approval by the FDA. The two-shot regimen provides around 95% protection.
More than 365,000 Americans have died as a result of the pandemic, according to data from Johns Hopkins University. The seven-day average positivity rate for the nation has continued to rise since Christmas, and stood at 13.6% on Thursday, according to the COVID Tracking Project. That's well above the 10% rate considered a marker of widespread contagion.
Biden spokesman Ducklo said the president-elect will share additional details next week.
Biden's plan to change the vaccine distribution plan was first reported by CNN.
AP reporter Michelle R. Smith in Providence, R.I., contributed to this report.
The Daily Citizen
Arkansas governor to get coronavirus vaccine next week
Batesville man arrested after state trooper dragged by vehicle Monday
Searcy attorney who ran youth baseball program says bond issue 'absolute waste of taxpayers' dollars'
Crashing into His House
Vaccinations voluntary for Unity Health staff; minor side effects seen
Searcy 60-year-old in parking lot collision Thursday appears to have died from medical condition
Searcy's police officer of the year values communities: work, neighborhood and church
Searcy 36-year-old facing charges for reportedly trying to kill police officer
Armed protests not concern for state representative from Searcy
Beebe School Board extends COVID emergency leave act provisions
Dog kennel in Judsonia to be repaired
White County Circuit Judge Craig Hannah rules Unity Health tax exempt (1)
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(3) Sun Oct 07 2007 07:20 Pseudonyms: This is a pretty easy one to start with. Patrick Nielsen Hayden said at one point that writers need to be brands, and for this entry I'm going to take that very literally. A writer's name is a brand, the same way a publishing imprint is a brand. There are many reasons for putting a name on your writing that's not the one on your birth certificate, but they all have to do with branding.
Your name might be uneuphonic, difficult to spell or pronounce, or very long. The same reason a lot of performance artists use stage names.
You might use different names when writing in different genres. Genre readers are pretty picky, and if you put the same name on all your books, bookstores may not stock as many of your titles. Publishing imprints work on this principle.
If you get caught in the midlist death spiral (which is definitely caused by an algorithm, though I'm still going back and forth on whether it's a bad algorithm even by the shortsighted standards of big business), changing your pseudonymn can be an effective way to fool the algorithm and reboot your career. Publishing imprints also contain elements of fooling bookstores' algorithms.
Through the workshop I got wildly varying assessments of my story's position on the Mohr scale of science fiction, and I'm pretty sure this had to do, not with the GCToL directly, but different readers' perception of the mass market's perception of the GCToL.
Despite the not-terribly-surprising fact that the vast majority of people who write SF under their initials are women (there was a survey on this topic but I can't find a link), readers tend to assume that unless the writer's unambiguously feminine name is spelled out for them, the writer is male (different survey, ditto on link). I guess even thinking about it requires confronting the prejudice.
It's still a little early for me to be picking out my science fiction pseudonym, but I'm considering writing under my initials 1) out of solidarity with female SF writers, and 2) to avoid confusion with the two nonfiction books already published under my full name. However, it's difficult for me to pass up an opportunity to sow confusion.
I think your name has a good rhythm to it; it seems like an important factor in a name's musicality is that it has different numbers of syllables in the first name and surname, and also some good trills. I think I would be more interested if I noticed a sci-fi book by an O'Reilly author, not confused. But the solidarity point is intriguing.
I was already trying to pick out a sci-fi pseudonym in high school because my name has lousy rhythm and six hundred dental stops. I tentatively settled on my middle names, which are much lighter and differently numbered, and (I've just noticed) gender-neutral. That's probably unworkable now, as I've invested four years in trying to get a brand off the ground under my real name.
I think Douglas Adams said that a writer's name should ideally be composed of a common longer first name with a shorter (it it can appear larger) Algo-Saxon last name: Douglas Adams, Stephen King, etc.
Also, pfft, forget your name. I want to see your brand's logo.
"However, it's difficult for me to pass up an opportunity to sow confusion."