According to tradition, the Pharisee originated on the North Frisian island of Nordstrand, in the 19th century. At that time there was the particularly ascetic pastor Georg Bleyer. For the Frisians, it was customary not to drink alcohol in his presence. At the baptism of the sixth or seventh child of the farmer Peter Johannsen they used a cunning and prepared the first mixed drink. The cream cap prevented the rum from evaporating in the hot coffee and the smelling of alcohol in the room. Of course, the pastor always got a "normal" coffee with cream. Upon discovery, he is said to have exclaimed: "Oh, you Pharisees!" And so the national drink of the North Frisians not only had its history, but also its name. The story of the drink was told in the 1970s by the North German music group Godewind in a song entitled Pharisee.
Basis of a Pharisee is strong, freshly brewed coffee, sweetened with sugar cubes and mixed with a good shot (about 4 cl) of brown rum (Jamaican rum or Jamaican blend with 54% vol.), Then whipped cream is added over it. A funny fact as I think, that shows peoples priorities is, that in 1981, the District Court of Flensburg has ruled in the so-called "Pharisee dispute" that 2 cl of rum were not sufficient for a Pharisee. So be sure to be spiced up anytime you will enjoy this liquid. The Pharisee is usually not stirred, but drunk through the cream. Those who do not stick to it and still stir the drink can be asked to spend a local round. It is often served in a special Pharisee place setting, a tall cup-like cup with saucer.
I am actually not to far from the original (and there comes the but), besides my drink is enjoyed on the rocks and the Rum is only in the cream top. So what did I do? Thanks to my new iSi toys, I wanted to try out a rapid cold brew in only a fraction of the actually time needed. Imagine getting a craving for this drink and having to wait until the next day. Not gonna happen here. Anyways as the base worked out very yummy, I simply foamed the rum up and piped it on top. My conclusion: well it went down quite well and I poured myself a second glass, if that might answer it.
For the base, just fill all ingredients into the iSi bottle with a Rapid Infusion top. Insert one cream charger and leave it to flavor in the fridge for at least one hour. Then release the gas and strain the base through a fine sieve. Put the base in the fridge until serving.
For the RumChata foam, mix all the ingredients together and fill it in an iSi bottle (0,5L). Screw the cream charger onto the bottle and shake it for 2 seconds.
To serve, take a piece of orange peel and flavor the edge of a tumbler, filled with ice. Shake the base with ice until nicely cold. Pour the base into the tumbler and pipe some of the RumChata foam on top.
Für die Basis, alle Zutaten in eine iSi Flasche füllen und einen Rapid Infusion Aufsatz verwenden. Nun eine Sahnekapsel aufschrauben und alles für mindestens 1 Stunde kalt stellen. Danach das Gas entweichen lassen und durch ein feines Sieb passieren. Den Mix bis zum servieren kalt stellen.
Für den RumChata Schaum, alle Zutaten verühren und in eine iSi Flasche (0,5L) füllen. Eine Sahnekapsel aufschrauben und kurz schütteln.
Zum Servieren, mit einem Stück Orangenschale den Rand eines mit Eis gefüllten Tumblers parfümieren. Die Cold Brew Basis auf Eis kalt shaken. Nun über das Eis geben und mit dem RumChata Schaum auftoppen.


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Home » Assembly in Action: Arm Speeds Inspection
Assembly in Action: Arm Speeds Inspection
As demand for just-in-time delivery increases, manufacturers of fabricated parts are discovering a new bottleneck in production--inspection. They must now increase parts production, but maintain high quality. However, the science of part making has surpassed the science of part checking.
Morton Metalcraft Co. (Morton, IL)--a large contract fabricator of sheet metal parts for manufacturers of farming, off-highway and industrial products--faced this obstacle when it teamed with John Deere & Co. to develop two cab frames for a new G Series backhoe.
Producing the new cab frame was daunting, particularly from the inspection standpoint. Although the company had relied on state-of-the-art digital inspection equipment and CMMs, these were too slow to meet the production requirements. Something faster and simpler was needed.
To qualify for the new cab contract, the company had to manufacture and inspect each unit at the required rate. This includes checking surfaces for parallelism; hole patterns; position of attachments, such as headliner hangers; and gross dimensions.
Testing their previous digital inspection system on a cab mockup, engineers discovered that it would take two men approximately 4.5 hours to fully inspect each unit. At the projected volume, total inspection of every unit would require 270 man-hours per day. Inspection would need paring down to a fraction of that, with inspectors checking only key characteristics. However, to prove that the company had the capability to make and deliver the product, it had to demonstrate inspection of all units, 100 percent if necessary.
"If we had to rely on our previous inspection system, we would never have gotten the job," explains Eric Johnson, division manager of quality services. "We had to find a new way to attack the problem."
To address the need, Morton installed FARO Technologies' (Lake Mary, FL) FaroArm digital measuring system. This digital measuring system, called Control Station, uses the same electromechanical components as a conventional FaroArm. However, a new computer and software speeds up and simplifies dimensional inspections.
The FaroArm is set on or near the product, and is mounted magnetically or by clamps. The Control Station is equipped with a touch-sensitive monitor that is attached to the base of the arm. This displays the part, or section of the part, that is being inspected, and it can be swiveled for easy viewing. Measurement accuracy is ±0.001 inch depending on the size of the part. When mounted inside the backhoe cab, the arm can reach all the required measuring points without being repositioned.
The points to be measured are embedded in the software, and operators are directed to these points. Thus, the need for an operator to search for key points is eliminated.
The Control Station software programs, known as Softcheck Tools, are written for individual products or parts. The routine screen presents the operator with a series of product photos that show full inspection or several partial inspections. The operator makes a selection by pressing the screen. The screen defaults to the selected inspection routine's first step. A photo of this selection fills the screen. Small colored balls, which are the measurement points, then appear superimposed on the photo. A highlighted instruction line appears on the screen and tells the operator where to touch the cab with the arm's stylus.
To take the measurement, the operator touches the point and presses a button on the stylus handle. This records the dimension, the computer acknowledges the completion, and the first green ball disappears. A broken arrow appears and points to the next measuring spot.
For points with critical tolerances, or when there are many points to check and the inspection process is hurried, the Softcheck Tool has a "target acquisition" mode. This helps operators find the exact spot to measure.
When the inspection is complete, two types of reports are available. Inspection reports, showing point-by-point tolerance data, are provided in spreadsheet format. Also, SPC graphical reports can be produced to show process trends.
One advantage of this software-directed inspection is repeatability. "I can run the system on one shift, then turn the equipment over to someone on the next shift, knowing that we will both be measuring the same points," explains Frank Lewis, an inspector.
With this system, the company cut inspection time from 4.5 hours, for two operators, to less than 45 minutes, using only one operator.
For more information on digital measuring systems, call FARO Technologies at 800-736-2771, visit www.faro.com.
Assembly in Action: Hybrid Assembly System Speeds Needle-free Injector to Market
Assembly in Action: Software Speeds Up Process Documentation
Assembly in Action: Automation Speeds Wire Processing
Assembly in Action: Cylinder Speeds Labeling

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Object to dictionary I want to create a dictionary by List of object for example
public class personne
{
   public string code {get; set;}
   public string ItemName {get;set;}
   public string Adresse {get;set}
}

I want to have for each property an element in the dictionary, whose name of the property represents the key and the value is a list of strings which are the values of the list using linq:
Dictionary<string, List<string>> test = new Dictionary<string, List<string>>();

key = proprety
value = values of property

A: Well, what prevents you from building this dictionary manually? This is certainly the most efficient approach(no reflection) and even with more properties not too much work:
List<personne> persons = new() { ... };

Dictionary<string, List<string>> dict = new()
{
   { nameof(personne.code), new(persons.Count) },
   { nameof(personne.ItemName), new(persons.Count) },
   { nameof(personne.Adresse), new(persons.Count) }
};

foreach(var person in persons)
{
    dict[nameof(personne.code)].Add(person.code);
    dict[nameof(personne.ItemName)].Add(person.ItemName);
    dict[nameof(personne.Adresse)].Add(person.Adresse);
}

A: If you are looking for a way to do this on demand for any object, something like the following will work via reflection:
var personne = new Personne
{
    code = "codevalue",
    ItemName = "ItemNameValue",
    Adresse = "AdresseValue",
    Adresses = new List<string> { "AdressesValue" }
};
var dict = ObjectToDictionary(personne);

public static Dictionary<string, List<string>> ObjectToDictionary<T>(T input)
{
    var properties = typeof(T).GetProperties();
    var dict = new Dictionary<string, List<string>>(properties.Length);

    foreach (var prop in properties)
    {
        var value = prop.GetValue(input);

        if (value is List<string> valueList)
        {
            dict[prop.Name] = valueList;
        }
        else
        {
            dict[prop.Name] = new List<string> { (string)value };
        }
    }

    return dict;
}

Granted, there is a cost to this and you might want to consider using compiled expressions instead.

redpajama_set_name: RedPajamaStackExchange


text:
Owner of Ohio store ransacked by rioters says she's receiving threats for cooperating with police
"…Someone walking by approached us and said, 'When the store rebuilds, when you rebuild this, I'm going to come back and destroy it again and you.' He kept walking and was gone."
An Ohio business owner told "Fox & Friends" on Monday that she is receiving threats for cooperating with law enforcement officials investigating the looting of her cupcake store last month.
Kelly Kandah, the owner of Colossal Cupcakes in Cleveland, which was destroyed by looters, said some of those threats include people telling her that when her store is rebuilt, "it's going to get hit again."
She said she also received complaints that her cooperation with investigators is "unfair," that she shouldn't be cooperating with the FBI and that what she is doing is "against the cause, which I'm actually absolutely for the cause, but it's upsetting people that I would involve the police over something such as property."
Kandah said her store was ransacked while she and four employees were hiding inside a locked bathroom of the store on May 30 during protests over the death of George Floy
Kandah told "Fox & Friends First" earlier this month that she has owned the cupcake shop for nearly 10 years.
"My family built it up, [I] listened to it get absolutely destroyed," Kandah told "Fox & Friends First" on June 2. "That whole time we were locked in there … I just listened to everything getting shattered and crushed."
On Monday, Kandah told "Fox & Friends" host Ainsley Earhardt that the week after her store was destroyed, "I was showing some of the damage and I was leaving, a friend and myself, and someone walking by approached us and said, 'When the store rebuilds, when you rebuild this, I'm going to come back and destroy it again and you.' He kept walking and was gone."
Read more at Fox News
Muhammad Ali's son says dad would have hated 'racist' Black Lives Matter
PODCAST: 'Bolton is a Traitor, Should be Tried for Treason'


Personalized Educational Services is boutique educational consulting firm, working one-on-one with each client to provide a seamless and successful educational journey. Everyone at PES is committed to making your child's educational pursuits as rewarding as possible, and we are here to help them every step of the way. Our services range from tutoring through to graduate school placement, and everything in between.


text:
Closer Look: Epcot's Universe of Energy closing to transform into new "Guardians of the Galaxy" attraction at Walt Disney World
in Conventions, Disney, Disney's California Adventure, Disneyland Resort, Entertainment, Epcot, Events, Marvel, Theme Parks, Walt Disney World
Posted on July 17, 2017 by Mike Mack
After D23 Expo 2017, we now know that there are a lot of incredibly exciting new attractions coming to our favorite Disney parks. Epcot in particular received a lot of attention at the Expo, with their being several huge announcements in regards to the park. Perhaps the most exciting of which, is a new "Guardians of the Galaxy" attraction.
This will be the first Marvel-themed attraction to come to Walt Disney World and it will bring the popular unlikely group of heroes to Future World at Epcot.
Not many details were announced for the ride, except that it will be an E-ticket attraction and it will be a different experience from "Guardians of the Galaxy – Mission: Breakout!" in Disney California Adventure.
"Guests at Disney California Adventure already love stepping into the world of the Guardians of the Galaxy," Walt Disney Parks and Resorts chairman Bob Chapek said. "And we're excited to give the guests in Florida a chance to explore this world in a new way."
The concept art for the facade of the new attraction is littered with exciting details that could be showing off some impressive future meet and greets.
Probably the most recognizable and obvious details would be Rocket and Groot standing front and center as guests make their way to the new attraction. As two of the most popular characters in the franchise, this would be an incredibly popular meet and greet.
Right behind them is a Nova Corps ship, which you may recognize from the first film.
And not far from the ship, is a member of the Nova Corps which could make for a good meet and greet or perhaps a walk-around character, similar to the stormtroopers in Hollywood Studios.
Another member of the Guardians is present as well. Gamora, who has appeared in Disney parks in the past, appears to be posing for a photo with guests.
Along with some of our favorite character, there are also some less-than-familiar faces spread around as well.
"So the Guardians are going to take our guests on an out of this world adventure," Disney Imagineer Tom Fitzgerald said. "But it will still be very rooted in an Epcot story."
Fitzgerald may have meant this figuratively, but it is also true in a literal sense. Unfortunately, in order to build a new attraction, often times old attractions have to go. This will be the case here as the Universe of Energy pavilion will be closing for this new Guardians ride.
Universe of Energy, which is home to the Ellen's Energy Adventure attraction, was an original attraction at Epcot. Changes have been made to the attraction, but the building itself has been there since the park's opening day back in 1982.
The attraction, which stars Ellen DeGeneres and Bill Nye, is an educational moving theater attraction based on, you guessed it, energy. This version of the attraction began running back in 1996, surpassing the run of the original version.
It is always unfortunate when a classic attraction has to close. However, there is a great deal of excitement in the future for Epcot and this new "Guardians of the Galaxy" attraction is a big reason why.
Tagged:Bill NyeEllen DeGeneresEllen's Energy AdventureGamoraGrootGuardians of the GalaxyGuardians of the Galaxy – Mission: BREAKOUT!Nova CorpsRocket RaccoonUniverse of Energy
Copper Creek Villas & Cabins officially opens at Walt Disney World as DVC addition to Wilderness Lodge
Posted on July 17, 2017 by Sean Sposato
Closer Look: Star Tours pilot Rex returning to Disneyland, Walt Disney World with new role in 'Star Wars: Galaxy's Edge'
Posted on July 17, 2017 July 17, 2017 by Mike Mack
Closer Look: Future World concept art reveals the future of Epcot as Walt Disney World plans major park updates
Posted on July 17, 2017 by Cristina Sanza
Mike Mack
Mike is a writer that has covered comic cons, theme park events, video game showcases and other fun events. He is a fan of theme parks, sports, movies, Marvel comics and is a self proclaimed "nerd."
I know Disney gets what Disney's wants. But I thought they had a contract with Universal made up stating they weren't allowed to put any Marvel attractions in Walt Disney World Resort because Islands of Adventures Marvel Island?
It seems Disney interprets the agreement as applying only to specific characters, the majority of which are affiliated with the original Avengers (Iron Man, Captain America, Hulk, Thor, Black Widow and Hawkeye).
There's also the complex Sony agreement for Spider-man licensing for 6 movie roles specifically played by Tom Holland in the MCU. We have no idea how Tom Holland's Spider-man fits in with Universal's right to the character in Parks east of the Mississippi.
It seems as though Disney might be trying to create a legal case that IP created within their MCU exists outside of the licensing to Universal (ie, they are not the same characters), and as long as Disney doesn't touch IP outside of the MCU and bases its attractions off of their own IP within the MCU (backstories, costumes, and films), they may try to begin pushing them into Parks to see if Universal wants to bring a case–who, by the way, may no longer be as concerned now that they have Harry Potter and Jurassic Park.
Right now, they appear to be operating under a gentleman's agreement, with Disney not touching Avengers east of the Mississippi, and Universal not attempting to bring a case against Disney for Guardians and Dr. Strange.
Jeff R.
Universal's theme park rights are limited and never covered the Guardians. They don't get every character and any new rides have to be approved by Marvel. That's not to say that Universal couldn't cause a problem as they almost sued Disney for advertising The Avengers on their monorails (an agreement was reached on that).
Unless Disney pays massive money to their biggest theme park competitor in Orlando, Universal is not giving up their rights. Disney would basically have to fund the rebuild of Marvel Superhero Island. Universal also holds distribution rights for The Hulk movies as well when he is the main feature character. They actually had to tread very carefully with Thor: Ragnarok in regards to Hulk.
There's likely some Quid Pro Quo involved here. There has long been rumor that the Doctor Doom FearFall may be removed at some point. Universal would need Disney to approve a new attraction. Universal has been awfully nice not suing for ads and not contesting a Guardians ride at Epcot. So we could see Disney allow for a new Marvel ride at Universal as part of a gentleman's agreement concerning this stuff.
Jeany Sanchez
Awesome news! I can't hardly wait to see it in person in the near future! I love Guardians of the Galaxy!
Older Older post: Copper Creek Villas & Cabins officially opens at Walt Disney World as DVC addition to Wilderness Lodge
Newer Newer post: VIDEO: Celebrate Disneyland's 62nd birthday with Mickey Mouse and sixty-two of his closest friends


Batwoman appeared on the CW Elseworlds crossover and now she's ready for the big time, but are you ready for her?
One of the most famous couples in the DC Universe gets the Vinimates treatment, based on their ARROW appearance.
Arrow Season 7: Are We Finally Getting David Goyer's Escape From Super Max?
Halloween may not be here yet, but that didn't stop a horde of horror- (and hero-) related items from shipping to comic shops this week!
New toy alert! A new Previews catalog is out, offering for pre-order a variety of Diamond Select Toys products, many first seen at the New York Toy Fair!
Every year, the International Toy Fair in New York delivers a score of toy-related images onto the Internet, many of them items that are being seen for the first time.
Diamond Select Toys has been capturing the world of DC Comics TV shows in 3-D form for a while now, with action figures and Minimates based on Gotham and iZombie.


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Mainstream Group Holdings Limited (ASX:MAI) CEO, Martin Smith talks 1H19 results, business initiatives, industry trends and 2H19 outlook.
Jessica Amir: Thanks for your company. I'm Jessica Amir for The Finance News Network, and with us today from Mainstream Group Holdings (ASX:MAI) is CEO Martin Smith. Hi Martin, and welcome back.
Jessica Amir: Thanks for coming. So first up, just give us a quick introduction to the business.
Martin Smith: So Mainstream (ASX:MAI) is a full-service fund administrator. We operate in eight countries. We were formed in 2006 in Australia, and we've been listed on the ASX since October 2015. As a full-service fund administrator, we provide the back office services for a range of fund managers. We have approximately 300-odd clients.
Jessica Amir: Now to your first half 2019 results, can you take us through some highlights?
We've grown the business since we listed from circa $14 million in 2015 to north of $50 million, and we've seen that growth continue in the first half. We had revenue growth of 32 per cent. We also had EBITDA growth of 20 per cent.
Jessica Amir: Now can you tell us about what you do in the fund admin side of things, starting with full service?
Martin Smith: So the full service fund administration includes investor services, what we call investment administration, fund accounting, and for some clients performance and compliance.
Jessica Amir: And can you tell us about your private equity administration?
Martin Smith: We've opened a business in the US, providing private equity administration. It's quite unique, versus providing equity administration. It's typically for larger assets that are privately held. It can be private debt, it can be property, or it could be venture capital. The growth in the US in what they call private equity markets is phenomenal. There are circa 52 and a half thousand private equity funds in the US that are registered with the SEC, and to be registered with the SEC you need to have assets more than $150 million.
Last year in Australia as a comparison, there were 32 new private equity funds. In the US, there were three and a half thousand. So we've been investing in the US business. We hired a team in January 2018. Rather than do an acquisition, we did an organic growth investment, and we've got a team based both on the east and west coasts, and they're growing that business organically.
Jessica Amir: And another one of your business key areas is custodial services.
Martin Smith: So, we have about $150 billion of assets, and we've had a full-service custody license since 2012. But to offer that service you must have $10 million of regulatory capital on your balance sheet all the time. So we, in September 2018 we raised $9.5 million to allow us to meet our regulatory capital needs, and we've been offering that service to a range of our clients. And that business has grown in those four months to circa five billion of assets that are now in custody. We make money off what we call safekeeping of those assets, but we also make money by being able to aggregate the cash of multiple clients and we have at the moment about $350 million in our cash custody, and the banks offer us higher interest rates than any one manager could get on their own, and we make a margin on that.
Jessica Amir: Zooming out to the business level more broadly, what can you tell us about your finances?
Martin Smith: So the thing in the half year that we're excited about was while the markets corrected circa 10 per cent, our assets under administration actually grew six per cent. Three reasons for that. The first reason was we on-boarded a number of new clients. Our hedge fund business generally is defensive against a falling market, and our custodial business took on and then managers converted a number of their investments into cash, which allowed for protection against market correction.
Jessica Amir: And over the past six months, how has your funds under management grown, and can you touch on your share price as well?
Martin Smith: Our funds under administration reached $147 billion, as at 31 December. We had a net flows, or increase of $8.3 billion, which equates to six per cent, and the general market had fallen 10 per cent in that half year. So we're really pleased with the net result. It was actually a gross in-flow of $14 plus billion, and market correction took six billion.
On our share price, we did a capital raise in September last year at $0.70 cents. There's probably a little bit of an overreaction to the markets and our exposure to the markets. We're currently trading at circa $0.63 to $0.64 cents. We have two analyst research reports out there recommending a buy north of $0.80 cents.
Jessica Amir: Just a more general question now, Martin. What are the industry tailwinds, and what do you see as your major competitive advantage?
Martin Smith: Probably the first one is that more people are outsourcing these services because of operational compliance and cost of technology. That'd be the first tailwind. You're also seeing compulsory superannuation compounding the amount of assets and the in-flows into those assets, and we're definitely a beneficiary of that. And the markets that we only entered in the last couple of years, we now have a robust platform to offer to clients, and our brand is better-known in those markets so we're seeing a lot more inquiries.
Jessica Amir: Wonderful, and we look forward to watching you grow. Martin Smith, thank you so much.


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1/22. Renal granulomatous sarcoidosis in childhood: a report of 11 cases and a review of the literature.
We analysed retrospectively 11 children with renal granulomatous sarcoidosis confirmed by renal histology in order to describe the course and prognosis of the disease. Symptomatic sarcoidosis was diagnosed at a mean age of 10.1 years. Nine children had renal involvement at the time of diagnosis. In the course of the disease, nine patients developed renal failure and mild proteinuria, seven had transient sterile leukocyturia, four showed microscopic haematuria, seven had a urinary concentrating defect, and enlarged kidneys were seen in three patients. One child had hypercalcaemia and hypercalciuria, none had hypertension. light microscopy of the kidney showed interstitial infiltration by mononuclear cells in all children, interstitial fibrosis in nine patients, epithelioid granulomas in seven, tubular involvement in eight, and mild glomerular involvement in seven patients. Renal immunofluorescence was negative. Ten children received prednisone for 1-11 years. After a mean follow up of 5.5 years, three patients had entered end-stage renal failure and one had chronic insufficiency after interruption of medical supervision and prednisone therapy. CONCLUSION: Renal failure, proteinuria, leukocyturia, haematuria, and concentration defect are the prominent features of renal granulomatous sarcoidosis in children. Steroid therapy, adjusted according to disease activity, may prevent end-stage renal failure.
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2/22. A familial syndrome due to Arg648Stop mutation in the X-linked renal chloride channel gene.
We describe a familial syndrome in two brothers who were investigated after the casual discovery of tubular proteinuria in their 1st month of life. During a follow-up of 20 and 11 years, respectively, the two children grew well and were asymptomatic, but developed the same biochemical abnormalities, i.e., tubular proteinuria and hyperphosphaturia, progressive decrease in serum phosphorus below the normal values for age, and an increase in serum 1,25-dihydroxyvitamin D levels over normal values. Moreover, hyperabsorptive hypercalciuria and systemic osteopenia developed and progressively worsened. In both children, at a different age, medullary nephrocalcinosis appeared. The oldest boy suffered a progressive decrease in urinary concentration ability and in glomerular filtration rate. Oral phosphate supplementation led to reversal of all biochemical abnormalities, with the exception of decreased phosphate tubular reabsorption and tubular proteinuria. With long-term phosphate supplementation, a normal bone mass was reached, while progression of nephrocalcinosis was arrested and impairment of renal function was slowed down. In a family study (siblings and parents), the only detectable abnormality was microglobinuria in the mother, thus suggesting a X-linked inheritance of this disorder. In the two probands a mutation within the renal chloride channel gene (CLCN5) was discovered.
3/22. Hypomagnesemia due to renal disease of unknown etiology.
A young man, investigated because of tetanic convulsions and arthritic pains, was shown to have hypomagnesemia, hypermagnesuria, hypokalemia, hypercalciuria, progressive nephrocalcinosis and chondrocalcinosis. In this syndrome, renal function was normal except for the abnormal excretion of electrolytes. Renal sodium conservation was normal. light and electron microscopic studies of renal biopsy specimens showed the presence of several abnormal tubules. Immunofluorescent staining showed deposits of immunoglobulins in the glomeruli and tubules. magnesium therapy was started under balance study conditions and resulted in decreased calciuria and complete remission of subjective symptoms. The progression of nephrocalcinosis was halted, and there was some decrease in the intra-articular calcium deposits after two years of continuous oral magnesium therapy. The administration of spironolactone decreased urinary magnesium but did not normalize it, whereas triamterene administration was without effect in this respect. The results of the morphologic and electrolyte balance studies are discussed. The patient was found to exhibit several features which have not been described before in connection with hypomagnesemia of unknown origin.
4/22. Renal hypomagnesemia, hypercalciuria and nephrocalcinosis in a middle-aged man.
We report a 41-year-old man with hypomagnesemia, hypercalciuria, nephrocalcinosis, myopia and horizontal nystagmus. The hypomagnesemia was due to primary renal magnesium loss. He was diagnosed as having the syndrome of renal hypomagnesemia, hypercalciuria and nephrocalcinosis. This is a rare condition generally diagnosed by the first to third decades of life. Renal failure is common and end-stage renal disease can occur in children or young adults. The patient was treated with oral magnesium, chlorthalidone, potassium citrate and allopurinol and was followed up for 3 years. Treatment resulted in an improvement in hypercalciuria but serum magnesium level could not be normalized. The patient's renal function remains stable, with a mild degree of renal insufficiency.
5/22. Acute lymphoblastic leukemia presenting with lactic acidosis and renal tubular dysfunction.
Acute lymphoblastic leukemia (ALL) in children can rarely present with severe lactic acidosis in the absence of a high white blood cell count or other complications. Renal tubular dysfunction with hypercalciuria and hypocalcemia in the absence of pre-existing renal disease or concurrent medications has not been described at presentation in childhood ALL. The authors describe a 7-year-old boy with ALL presenting with severe lactic acidosis and renal tubular dysfunction, both of which were refractory to conventional management and resolved rapidly with appropriate chemotherapy.
6/22. hypertension associated with diffuse small artery calcification: a case report.
Renal ultrasound examination, performed following a urinary tract infection in a 4.5-year-old girl with triple X syndrome, showed multiple echogenic foci at the corticomedullary junction in both kidneys. She was asymptomatic but had hypertension with echocardiographic evidence of left ventricular hypertrophy. Computerised tomographic scan revealed foci of calcification in the kidneys, spleen and pancreas. On biopsy calcification was found in the internal and external elastic laminae of the superficial temporal artery and in the internal elastic lamina of a renal arcuate artery. Intimal fibrosis was mild and focal. No other arterial calcification was demonstrated radiographically or by ultrasound. Biochemical and hormonal profiles revealed no abnormality except hypercalciuria. The aetiology and prognosis of this child's condition are unknown. Although similar ultrasound and histological appearances have been described in pseudoxanthoma elasticum and in idiopathic arterial calcification of infancy, there is no evidence that the child has either of these conditions.
7/22. Hypercalcaemia in infancy; a presenting feature of spinal muscular atrophy.
A 10 month old girl presented with a history of constipation from early life. She was found to be hypercalcaemic with hypercalciuria and nephrocalcinosis. Her mild motor delay and hypotonia were thought to be linked to chronic hypercalcaemia, but when these features failed to improve despite normocalcaemia on a low calcium diet the possibility of neuromuscular disease was explored in more detail. She was subsequently found to have spinal muscular atrophy type 2. We suspect that the hypercalcaemia with hypercalciuria observed in this case reflects altered bone turnover secondary to reduced muscular activity.
8/22. Examination of megalin in renal tubular epithelium from patients with dent disease.
dent disease is characteristic for the urinary loss of low-molecular-weight proteins and calcium, leading to renal calcification and, in some patients, chronic renal failure. This disorder is caused by loss-of-function mutations in the renal chloride channel gene, CLCN5. The animal model of this disease has demonstrated the possible role of disturbed megalin expression, which is a member of the low-density lipoprotein receptor family and is associated with renal reabsorption of a variety of proteins, in dent disease. We examined the expression of megalin in the renal tubular epithelium of two unrelated patients with dent disease. One patient, whose CLCN5 gene was completely deleted, showed significantly decreased staining of megalin compared with controls, while there was no change in another patient with partial deletion of the gene. These results demonstrated that mutation of CLCN5 in some patients with dent disease may impair the expression of megalin, resulting in abnormal calcium metabolism, manifested as hypercalciuria and nephrocalcinosis.
9/22. Hyponatremic-hypertensive syndrome with extensive and reversible renal defects.
Two young children with renal artery stenosis and severe hypertension who presented with the so-called hyponatremic-hypertensive syndrome (HHS), with marked urine and solute loss during the acute phase, are described. Both children also presented with severe high molecular proteinuria, glycosuria, and hypercalciuria, only the first symptom having prompt remission after normalization of blood pressure. In children with renal artery stenosis, HHS is associated with severe proteinuria due to hyperfiltration and more extensive tubular functional alterations. hyponatremia and acute tubulopathy may mask the presenting clinical picture of renal artery stenosis.
10/22. A case of renal sarcoidosis: a special reference to calcium metabolism as a diagnostic and the therapeutic implications.
sarcoidosis is a systemic granulomatous disease of unknown etiology and is associated with a wide variety of renal disorders including nephrolithiasis, hypercalciuria, hypercalcemia, nephrocalcinosis, tubular defect, glomerulonephritis, and granulomatous interstitial nephritis. We report a case of renal sarcoidosis in which we could not detect any evidence of extrarenal involvements that was diagnosed by renal biopsy and abnormal calcium metabolism incompatible with chronic renal insufficiency. On laboratory findings, decreased creatinine clearance, proteinuria, hypercalcemia, hypercalciuria, and mildly elevated serum angiotensin-converting enzyme (ACE) were seen. serum intact parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (1,alpha-25 vit D) were lower and higher than normal range, respectively, whereas the patient was already in chronic renal insufficiency. He was treated with oral corticosteroid. serum ACE tended to fall, and 1,alpha-25 vit D level decreased with substantial fall of serum calcium and daily calcium excretion. In contrast, intact PTH increased slowly in accordance with a fall of serum calcium compatible with the level of renal impairment. creatinine clearance and daily excretion of protein improved. The case reported here may propose that serial measurement of serum level of 1,alpha-25 vit D, calcium level, and magnitude of daily calcium excretion into urine is a simple and meaningful tool to detect the therapeutic response in sarcoidosis with abnormal calcium metabolism.
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Engineering apprentices from across Lancashire have showcased their flair and skill at an annual open day hosted by Training 2000.
The 200 apprentices have just completed 42 weeks off-the-job training at Training 2000's state-of-the-art centres and proudly presented their work to employers, friends and family.
The budding engineers completed specialist training in areas such as CNC machining, turning and milling, electrical engineering, CAD and design, welding and fabrication, maintenance and pneumatics.
Seventeen year old apprentice, Luke Allison, from Preston said: "I enjoyed my first year off the job training and I've learnt a lot. It's great to be able to showcase our work to our friends, family and the boss.
Companies including 3M, Lupton & Place and Graham Engineering were in attendance to see the progress made by their apprentices.
Training 2000's popular engineering Apprenticeship programme has won countless awards for excellence and is renowned for its relevance to industry requirements.
The state-of-the-art facilities give learners the opportunity to develop their skills on up-to-date equipment and techniques and the completion rates are well above the national average.
Two apprentices studying with Blackburn-based Training 2000, the largest Group Training Association in England, have been recognised at the annual North West Aerospace Alliance New Talent Awards (NWAA).
The awards are part of the NWAA's Take off In Aerospace Campaign aimed at encouraging young people in to the industry by changing the image of careers in aerospace and engineering sectors.
The glittering ceremony, held at the Imperial War Museum, Manchester on 28 November 2013, saw awards being given to the region's best emerging talent, along with the training providers and companies which support their work.
Ryan Worthington, 20, from Preston, walked away with the 'One to Watch' trophy and Tamas Bodis, 39 from Chorley, received the runner-up prize in the Best Apprentice category. Both work for Rolls Royce in Barnoldswick.


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Avengers #341-342, Quasar #28-29, and Amazing Spider-Man #354 (November-December 1991)
These two issues, guest-starring the New Warriors (including two future Avengers) and written by their regular scribe Fabian Nicieza, focus on Rage amidst heightened racial tensions in New York City, courtesy of the fella on the second cover, who adopts a familiar villain name (unfortunately well deserved). Also, we get a couple issues of Quasar's book, curiously following up on a recent Alpha Flight story the Avengers were involved in, as well as a quick appearance of the Sentinel of Liberty in Amazing Spider-Man. (Get comfortable: This post is a little longer than most, all for the same low price!)
Avengers #341 begins with a news report of a fifteen-year-old boy named Carmello Martinez being beaten by several NYPD officers, which escalates racial tensions between the black and Latino communities, the police, and a small group of white racists. Rage confronts the last group, and after scaring them off, gives a nearby television reporter a piece of his mind about the local police. The reporter refers to him as the "Avengers' spokesman," as we see below when Peggy and Mike watch the report while Rage trains with Captain America and the Falcon in the gym.
Rage gets enr… umm… frustrated and breaks the boys' toys, forcing Cap to step in and fix things (getting a little workout himself).
Cap confronts Rage about his outburst, but the younger hero just wants to know why they're not doing something about the clubbing, consistent with his complaints about the team's focus when he first met Cap back in issue #326.
This time, Falcon delivers the company line, which might mean more given his background, but Rage couldn't care less.
Sam doesn't give up…
…but Rage is not satisfied with his calls for patience and tolerance, and storms off, leaving both Sam and Cap concerned.
It is safe to assume that Cap is picking up on more anger than usual coming from Rage, to which he refers above, so later he and Sam pay a visit to Rage's grandmother…
…who tells them that not only were Rage and Carmello good friends (explaining why he took the case so personally), but also that Rage is only fourteen years old (which they obviously did not know).
Later, the Sons of the Serpent, a white supremacist group first seen way back in issues #32-33, show up to contribute to the chaos, and are confronted by the New Warriors, soon joined by Rage. Soon, the heroes notice they are behaving more rashly and violently than normal, due to the fella below, a new Hate Monger…
…for whom the varsity team comes out to play.
Avengers #342 opens up with a fine splash of Cap's latest quartet, courtesy of Steve Epting and Tom Palmer, who will be the regular team on this book for the next three years.
The following double-spread is impressive as well…
…leading into a focus on Cap, who tries to calm down the police as well as Night Thrasher and then Marvel Boy, who is particularly conflicted, being one of Cap's greatest admirers.
After the Sons of the Serpent are forced to retreat, the Hate Monger leaves as well, and the combatants on the ground start to come to their senses, realizing that something had taken them over… except for Rage, who thinks the aggression was perfectly justified (for obvious reasons).
As you may know, in a few years Marvel Boy (when he goes by Justice) and Firestar will be standing among Cap and the rest as fellow Avengers. (We're getting there, just be patient!)
The assembled Avengers and New Warriors continue to debate the role of superheroes in addressing community unrest, with Cap and his teammates urging discretion and caution, especially if their presence could make a bad situation worse, while Night Thrasher agrees with Rage that they can't just stand by "when things are going south."
Rage reiterates his longstanding problem with the Avengers' approach and marches off…
…leaving Cap to address the rest of the "kids," praising their idealism while trying to bring it down to earth at the same time (which only sounds like defeatism to them, I'd imagine).
It doesn't help that he pulls rank on behalf of the Avengers and basically sends the New Warriors home, and Marvel Boy has to prevent Night Thrasher from fighting with his idol any longer.
Well that's settled, and I'm sure the New Warriors will never cause any problems again, nor will Cap ever have cause again to lecture young heroes about their lack of experience.
After the New Warriors chase after Rage, the Avengers figure out where the Sons of the Serpent are heading and wait for them there.
While Sam dismisses a racial epithet from one of the white supremacists, another writes off Cap as a traitor to his race.
After finishing the Sons of the Serpent off, Black Widow and Vision both joke about how easy it was, but Cap stresses it's better to cut them off now before their movement grows larger…
…which is clearly in the reappeared Hate Monger's interest.
Before the Avengers can engage, the New Warriors and Rage show up; Hate Monger tries to defeat them with blasts of hate (don't ask me how that works), but Rage has "more than enough hate of my own" to fight him with, which Hate Monger thinks make them friends. Rage disagrees, but it takes Cap's pleas to make him realize he's only playing into the Hate Monger's hands.
Cap tells the young hero that all of us must confront the hate in our own hearts…
…which Rage accepts, but about which the Hate Monger is more skeptical (of course).
Cap praises Rage for controlling his negative feelings, then not-so-subtly refers to his age. (I suspect there's a mistake in the text: I think time is something he has plenty of, due to his youth.)
Rage admits to being a teen (and a young one at that), and Cap admits to neglecting his responsibility to help train the next generation of heroes (referring to his earlier dismissal of Marvel Boy in New Warriors #1).
As they all go their separate ways, Night Thrasher gives Rage his card, setting the stage for Rage to join the New Warriors in their own issue #22.
Meanwhile, over in Quasar #28, "Her" has returned—the same "Her" who made the grammar a mess in the post on Alpha Flight #99-100—but first, we get a different view of the scene from Captain America #395, after Thor has his meeting in the principal's office, and Quasar is not pleased to follow him.
You think I'm joking? It's like a scene from "Saved by the Bell," starring Cap as Principal Belding, Quasar as Zack Morris, and Hercules as A.C. Slater.
The intruder is Her, whom Quasar recognizes, but she's here for someone else…
…at least at first. We soon learn that Her is searching for a mate, and attaches reproductive pods to the backs of several male heroes to see who is worthy of the role. (Dating was very weird in the 1990s.)
This situation naturally invites a wide range of guest-stars, including Squadron Supreme member Hyperion, introduced in Avengers #85, whom we see in Quasar #29 as Cap checks in with the title hero to let him know of more "candidates" chosen by Her.
She has auditioned Wonder Man and Leonard Samson, whom Cap redundantly introduces to each other…
…before Hyperion arrives, announced with a clever nod to his Kryptonian inspiration, before Cap clarifies whether he is a good Hyperion or a bad Hyperion. (There are any number of both, so you can never be too careful.)
Cap calls in Avengers medic Keith Kincaid to try to get the pod off Simon, while Samson uses his training and experience as a licensed therapist to come to a brilliant insight about Hercules.
Finally, in Amazing Spider-Man #354, the webhead uses his Avengers status to try to get in touch with Moon Knight…
…and Captain Belding indulges him, even though he could have done it himself. (A good principal is also a teacher.)
Hearing Spidey mention the Secret Empire must have brought back some memories for our hero!
Avengers (vol. 1) #341, November 1991: Fabian Nicieza (writer), Steve Epting (pencils), Tom Palmer (inks), Christie Scheele (colors), Michael Heisler (letters). (More details at Marvel Database.)
Avengers (vol. 1) #342, December 1991: Fabian Nicieza (writer), Steve Epting (pencils), Tom Palmer (inks), Rob Tokar (colors), Bill Oakley (letters). (More details at Marvel Database.)
Collected in: Avengers Epic Collection: The Collection Obsession.
Quasar #28 (November 1991): Mark Gruenwald (writer), Greg Capullo (pencils), Harry Candelario (inks), Joe Rosas (colors), Janice Chiang (letters). (More details at Marvel Database.)
Quasar #29 (December 1991): Mark Gruenwald (writer), Greg Capullo (pencils), Harry Candelario (inks), Paul Becton (colors), Janice Chiang (letters). (More details at Marvel Database.)
Not yet collected.
Amazing Spider-Man (vol. 1) #354 (late November 1991): Al Milgrom (writer), Mark Bagley (pencils), Randy Emberlin (inks), Bob Sharen (colors), Joe Rosen (letters). (More details at Marvel Database.)
Collected in: Amazing Spider-Man Epic Collection: Round Robin.
PREVIOUS ISSUE: Avengers #340 (October 1991)
ALSO THESE MONTHS: Captain America #394-395 (November-December), Infinity Gauntlet #5-6 (November-December 1991), Adventures of Captain America #2 (November 1991), Adventures of Captain America #3 (December 1991), and Marvel Holiday Special #1 (December 1991)
NEXT ISSUES: Avengers #343-344, Thor #444, and Wonder Man #5 (January-February 1992)
1991, anger, Avengers, compassion, Falcon, guilt, leadership, racism, Spider-Man, tyranny
Amazing Spider-Man #354, Avengers #341, Avengers #342, December 1991, November 1991, Quasar #28, Quasar #29
The Adventures of Captain America #2 (November 1991)
The Adventures of Captain America #3 (December 1991)