text:
package com.comandante.pushpackage;

import com.comandante.stickypunch.api.model.PackageSigner;
import org.bouncycastle.cert.X509CertificateHolder;
import org.bouncycastle.cert.jcajce.JcaCertStore;
import org.bouncycastle.cms.CMSProcessableByteArray;
import org.bouncycastle.cms.CMSSignedData;
import org.bouncycastle.cms.CMSSignedDataGenerator;
import org.bouncycastle.cms.CMSTypedData;
import org.bouncycastle.cms.jcajce.JcaSignerInfoGeneratorBuilder;
import org.bouncycastle.operator.ContentSigner;
import org.bouncycastle.operator.jcajce.JcaContentSignerBuilder;
import org.bouncycastle.operator.jcajce.JcaDigestCalculatorProviderBuilder;
import org.bouncycastle.util.Store;
import sun.security.rsa.RSAPrivateKeyImpl;
import sun.security.util.DerValue;

import java.io.FileInputStream;
import java.security.Key;
import java.security.KeyStore;
import java.security.PrivateKey;
import java.security.Security;
import java.security.cert.Certificate;
import java.util.ArrayList;
import java.util.List;

public class PackageZipSigner implements PackageSigner {

    private final PackageZipConfiguration packageZipConfiguration;

    public PackageZipSigner(PackageZipConfiguration packageZipConfiguration) {
        this.packageZipConfiguration = packageZipConfiguration;
    }

    @Override
    public byte[] sign(byte[] data) throws Exception {
        Security.addProvider(new org.bouncycastle.jce.provider.BouncyCastleProvider());
        KeyStore inStore = KeyStore.getInstance("PKCS12");
        inStore.load(new FileInputStream(packageZipConfiguration.pushPackageSignerCertPath), packageZipConfiguration.pushPackageSignerCertPassword.toCharArray());

        Key key = inStore.getKey(packageZipConfiguration.pushPackageSignerCertName, packageZipConfiguration.pushPackageSignerCertPassword.toCharArray());
        PrivateKey privateKey = RSAPrivateKeyImpl.parseKey(new DerValue(key.getEncoded()));
        Certificate certificate = inStore.getCertificate(packageZipConfiguration.pushPackageSignerCertName);
        X509CertificateHolder certificateHolder = new X509CertificateHolder(certificate.getEncoded());

        List certList = new ArrayList();
        CMSTypedData msg = new CMSProcessableByteArray(data); //Data to sign

        certList.add(certificateHolder); //Adding the X509 Certificate

        Store certs = new JcaCertStore(certList);

        CMSSignedDataGenerator gen = new CMSSignedDataGenerator();
        //Initializing the the BC's Signer
        ContentSigner sha1Signer = new JcaContentSignerBuilder("SHA1withRSA").setProvider("BC").build(privateKey);

        gen.addSignerInfoGenerator(
                new JcaSignerInfoGeneratorBuilder(
                        new JcaDigestCalculatorProviderBuilder().setProvider("BC").build())
                        .build(sha1Signer, certificateHolder));
        //adding the certificate
        gen.addCertificates(certs);
        //Getting the signed data
        CMSSignedData sigData = gen.generate(msg, false);
        return sigData.getEncoded();
    }
}

redpajama_set_name: RedPajamaGithub


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The Senate Commerce Committee has slated hearings next week related to Hurricane Katrina: one on energy pricing, set for Sept. 21, the other on communications Sept 22.
Co-chairman Daniel Inouye, D-Hawaii, indicate the first panel will address the protection of critical communications infrastructure in a disaster. The second will address communications for first responders.


This portable black leather case cigar humidor is something you don't see everyday! This piece is crafted in quality leather and accented with white contrast stitching for a commanding appearance. Sliding the case open reveals 2 removable cigar beds that can protect six 60 gauge cigars up to 8″ long. Don't have cigars that large? This case is completely versatile. Simply remove one or both of the cigar beds to allow for additional room to store up to 15 medium size cigars. Includes a strip style humidifier that is easy to access and sits perfectly at the end of the case. Cigars not included and are shown for display purposes only.


text:
Rebels Cheer
Coach Kennedy
Kennedy has been in the competitive cheerleading world for almost 8 years! Kennedy started cheerleading in high school at EMCS and then six months after she thought she had "retired" she learned about PCE and then joined the open team.
Kennedy has been a part of The Royal Family since Season 1 as an athlete, and she then had the opportunity to start coaching in Season 2! Kennedy has coached Senior Reign (in season 2 & 3) and Senior Majesty (in season 3) and she has also been on Open Dynasty as a flyer and as a base.
Kennedy says: "My favourite part of my cheer career would be coaching. It's an amazing feeling watching all the young athletes blossom into such confident individuals and I can't wait to continue to do that in the future! I'm so grateful to PCE, and Shannon for letting me spread my wings, and continue my cheer career!
Unit #210 -314 Wale Rd.
Victoria, BC V9B 1H8
empire.athletics@outlook.com

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Template Argument Binding What I want is something like std::bind for functions but for templates.
Assume I have a template which needs a template template with a defined set of arguments.
Now I have another template which would work but which has more arguments, so I need to convert this complex template into a simpler one with bound arguments.
To do this I created a template which defines an alias template.
If I use this binding template with concrete types this works well. But if I instantiate the binding template with another template argument, gcc and clang assume that the alias is not a template template. I know it becomes a dependent name, but there is nothing like the typename disambiguator for templates.
With icc and msvc this works fine.
template<
    template<typename> typename Template
>
class ATypeWhichNeedsATemplateTemplate
{
};

template<typename A, typename B>
class AComplexTemplate
{
};

template<
    template<typename...> typename ATemplate
    ,typename... Args
>
class Binder {
public:
    template<typename T>
    using type = ATemplate<T, Args...>;
};

template<typename T>
class AClassWithBoundTemplate : public ATypeWhichNeedsATemplateTemplate<
    Binder<AComplexTemplate, T>::type
>
{
};

see on godbolt
clang complains:
<source>:30:5: error: template argument for template template parameter must be a class template or type alias template

    Binder<AComplexTemplate, T>::type

    ^

gcc says something similar:
<source>:31:1: error: type/value mismatch at argument 1 in template parameter list for 'template<template<class> class Template> class ATypeWhichNeedsATemplateTemplate'

 >

 ^
<source>:31:1: note:   expected a class template, got 'Binder<AComplexTemplate, T>::type'

A: type is a dependent template name. You need to spell it like Binder<AComplexTemplate, T>::template type, i. e.:
template<typename T>
class AClassWithBoundTemplate : public ATypeWhichNeedsATemplateTemplate<
    Binder<AComplexTemplate, T>::template type
>
{
};

Fixed godbolt example: https://godbolt.org/z/7nJtAU

redpajama_set_name: RedPajamaStackExchange


NutraBox is an Indian nutrition supplement brand designed for the physique of Indian bodies. Our formulas are clinically tested and tried by fitness experts. We aim to provide you with your daily nutritional needs before, intra and after workout, while you focus on your goal to make a leaner and fitter body. All the NutraBox products are designed to give you wholesome nutritional results with the purest and the highest yielding ingredients. We understand your physique and needs and so, we intend to give you a product that best suits your routine, your requirements and your workout strategies.
Whey is a by-product that is obtained in the cheese making process. It has many commercial uses and one of them is Whey Protein Powder. It has a high nutritional result for the human body. No adulterations or solvents are used in the process of making whey protein powder. Whey protein plays a pivotal role in increasing the production of muscle protein in the human body which is required after an intense workout.
At NutraBox, We source our raw materials from the elite and our focus is to provide you with a pure protein experience.


WE THE PEOPLE pledge in the belief that our right to have an opinion is more valuable than our differences.
By taking this pledge, I will follow the Golden Rule: treat others as I would wish to be treated.
If you feel freedom, you will respect it.
You may be living in freedom without actually feeling it. When you don't feel something, it's difficult to appreciate its true value.
If we as Americans unite with the common understanding that although we may have differences in opinions, belief systems, and values, WE THE PEOPLE pledge that our right to have an opinion is more valuable than our differences. By actively acknowledging this common ground, our initial judgments (whether conscious or subconsciously) on our fellow brothers and sisters (regardless of race, gender, social status, sexual orientation, or career choice) is with respect through the development of compassion.
I pledge that our right to have an opinion is more valuable than our differences.
Compassion is an emotion that is a sense of shared suffering, most often combined with a desire to alleviate or reduce the suffering of another; to show special kindness to those who suffer.


text:
#721 Five British Columbia battalions
The Empire on the Western Front: The British 62nd and Canadian 4th Divisions in Battle
by Geoffrey Jackson
Vancouver: UBC Press, 2019
$34.95 / 9780774860154
Reviewed by James D. Barrett
Geoffrey Jackson's readable study of the performance of the 62nd Division British Expeditionary Force (BEF) and the 4th Canadian Division (CEF) hits the mark with a detailed analysis and comparison between these two new divisions that were raised mid-war and first saw service at the Battle of the Somme in late 1916. The 4th Canadian Division comprised sixteen infantry battalions, of which five were from BC: the 47th (British Columbia) Battalion Canadian Infantry, based in New Westminster; the 54th (Kootenay) Battalion Canadian Infantry, based in Nelson; the 67th (Western Scot) Pioneer Battalion Canadian Infantry, based in Victoria; the 72nd Battalion (Seaforth Highlanders of Canada), based in Vancouver; and the 102nd (North British Columbia) Battalion Canadian Infantry, mobilized in Comox.
Postcard of the 102nd (North British Columbia) Battalion, known as Warden's Warriors, leaving Comox, 1916
Cap badge of 102nd North British Columbians (Comox)
The senior leadership from the divisional commanders down to the battalion commanding officers of both organisations generally had some prior military experience and in many cases active service in 1914-15. A good example was Lt-Col Jack (John Weightman) Warden, Commanding Officer of the 102nd (North British Columbia) CEF, who was wounded at the 2nd Battle of Ypres at St Julien with the 7th (British Columbia) CEF, recovered from his wounds, received command of his battalion in Canada, and returned to action with the 4th Canadian Division in 1916.
54th Battalion (Nelson) CEF, Bronze cap badge
By 1916, the majority of the remaining junior officers and soldiers were recruits without any prior military training. Jackson's study compares the experiences of both divisions on how they were raised and trained, and their "learning curves" following their arrival on the battlefields, followed by the impact of both on their combat performance from late 1916 to the signing of the Armistice on 11 November, 1918. He does this very well, through telling the stories of each unit and highlighting both their successes and challenges.
Badge of 67th Battalion (Victoria) with cougar mascot
Jackson does not miss the communication issues that senior commanders had to deal with in the Great War, where up-to-date battle information from the front lines to rear headquarters was negligible once action had been joined. Although both Division and Brigade Commanders often went forward to ascertain progress, there was little they could do to influence success outside of sound staff work, planning, and effective employment of resources, especially the artillery.
Cap badge of 72nd Seaforth Highlanders (Vancouver)
Particularly challenging was to know when to shut down offensive operations. Combined with the difficulties experienced by the infantry in attempting to advance behind barrages that could not easily be adjusted to the changing situation on the battlefield, Jackson understands the difficulty of extending coverage for the infantry advance by the artillery beyond the initial ranges experienced at the start of the action, and especially the ratio of increased casualties for diminished gain when artillery support was lacking. Subsequently, he covers the development of the "bite and hold" tactics of 1917-18.
Cap badge of 47th Battalion (New Westminster)
Jackson does not miss the increasing autonomy of the Expeditionary Forces and the reductions of strength in the BEF Units in 1918, which did not occur in the Canadian Corps. These reductions in fact eliminated its 5th Division in Britain, which decreased both its overall strength and firepower effectiveness as "shock troops."
In his sound analysis of the growth of these two comparable units, Jackson notes the evolution of training within the BEF as well as the evolution of combat tactics by the Commonwealth Forces. By 1918, the BEF had devolved much forward leadership down to the platoon and section levels with an increase in firepower up front through more Lewis Machine Guns carried at the section level and the forward deployment of heavy machine gun assets for immediate fire coverage behind the artillery barrage. It is pleasant to see Jackson's acknowledgement of the fact that the British General Staff were using their lessons learned from 1916, with the assistance of the development of the tank and artillery improvements, to develop tactics that would lead to further successes in 1917 and ultimately to the last "100 Days" and the defeat of Germany. By 1918, both the 62nd and 4th Canadian Divisions were clearly up to par with their predecessors on the battlefield.
The 29th Infantry Battalion (Vancouver) advancing through German barbed wire in no man's land during the Battle of Vimy Ridge, April 1917. Photo by William Ivor Castle, Library and Archives Canada
A 4th Canadian Division colonel's helmet, with insignia on outside of helmet. Courtesy of eMedals
I did, however, have a few minor quibbles. Lt-Col Warden's last name is misspelled as Worden (p. 17). In his Battle of the Somme coverage, Jackson blames the artillery for not clearing wire effectively. This is quite true within the artillery's restrictions of 1916 in trying to destroy German wire using ground penetrating, aerial, and shrapnel shell bursts. They were simply not as effective as the later shells, as seen when the British Mark IV Shell Fuse came into service in 1917. Shells now exploded on the slightest touch of the wire: a very effective improvement.
Geoff Jackson
Finally, I would like to have seen more detail on the actual small party tactics developed from 1916 onwards, especially on how the platoon and section elements were reorganized with a view to survivability of the leadership and the extra use of firepower with the addition of the Lewis Light Machine Guns. The late Desmond Morton gave a very good lecture to our class in detail on this very subject when I was attending Staff College in Kingston in 1998. This is perhaps something to be explored in a future edition, and in no way takes away from the work Jackson has done here.
Geoffrey Jackson is to be congratulated for his efforts. The Empire on the Western Front is recommended reading for anyone interested in Great War history.
Major Jim Barrett
Major James D. Barrett, CD is a graduate of UBC Faculty of Education (Secondary) 1979 majoring in English and Social Studies (History & Geography). He joined the Canadian Armed Forces in 1982 as a member of The BC Regiment (Duke of Connaught's Own), an Armoured Reconnaissance Regiment that perpetuates the history of the 7th Bn, 29th Bn and 102nd Battalions CEF. A graduate of the Canadian Forces Staff College (Kingston) in 1998, he was promoted to the rank of Lieutenant-Colonel and commanded 15th Field Artillery Regiment RCA from 2007 to 2011. He retired as the Assistant Chief of Staff 39 Canadian Brigade Group Headquarters in 2013. In 2014, he returned to duty as a General Service Officer with the Cadet Organization Administrative and Training System and currently in the rank of Major commands 3300 BCR Cadet Corps in Surrey. In the summer months he resumes his former rank as LCol and commands the Rocky Mountain Cadet Training Centre in Alberta. He writes a quarterly history article for the BC Regiment's Newsletter, The Duke, and is a Director of the BC Regimental Association and Museum Societies. He is the Chair of the Board of Directors for the BC (Mainland) Military Family Resource Centre.
The Ormsby Review. More Books. More Reviews. More Often.
Publisher and Editor: Richard Mackie
The Ormsby Review is a journal service for serious coverage of B.C. books and authors, hosted by Simon Fraser University. The Advisory Board consists of Jean Barman, Robin Fisher, Cole Harris, Wade Davis, Hugh Johnston, Patricia Roy, David Stouck, and Graeme Wynn. Scholarly Patron: SFU Graduate Liberal Studies. Honorary Patron: Yosef Wosk. Provincial Government Patron since September 2018: Creative BC
"Only connect." – E.M. Forster
#720 Masks, midgets, and junk culture
#722 A punchy and brilliant debut


text:
package components

import (
	"k8s.io/kops/pkg/apis/kops"
	"k8s.io/kops/upup/pkg/fi/loader"
)

// DefaultsOptionsBuilder adds default options.  This should come first!
type DefaultsOptionsBuilder struct {
	Context *OptionsContext
}

var _ loader.OptionsBuilder = &DefaultsOptionsBuilder{}

// BuildOptions is responsible for cluster options
func (b *DefaultsOptionsBuilder) BuildOptions(o interface{}) error {
	options := o.(*kops.ClusterSpec)

	if options.ClusterDNSDomain == "" {
		options.ClusterDNSDomain = "cluster.local"
	}

	if options.ContainerRuntime == "" {
		options.ContainerRuntime = "docker"
	}

	return nil
}


text:
require 'json'
require 'pp'

class Doodle
  module JSON
    # main one
    def self.parse(*a, &b)
      ::JSON.parse(*a, &b)
    end
    def self.method_missing(*a, &b)
      ::JSON.send(*a, &b)
    end
    module InstanceMethods
      def to_json(*a)
        # don't include default values
        values = doodle.key_values_without_defaults
        value_hash = Hash[*Doodle::Utils.flatten_first_level(values)]
        {
          'json_class'   => self.class.name,
          'data' => value_hash,
        }.to_json(*a)
      end
    end
    module ClassMethods
      def json_create(o)
        #pp [:json_create, o]
        const = Doodle::Utils.const_resolve(o['json_class'])
        const.new(o['data'])
      end
      def from_json(src)
        v = ::JSON::parse(src)
        if v.kind_of?(Hash)
          new(v)
        else
          v
        end
      end
    end
    def self.included(other)
      other.module_eval { include InstanceMethods }
      other.extend(ClassMethods)
    end
  end
  include Doodle::JSON
end


text:
Clinicopathological Significance of SALL4 and BECN1 Tissue Protein Expression in Serous Ovarian Carcinoma (SOC); An Immunohistochemical Study.
Journal of Clinical & Experimental Pathology
J Clin Exp Pathol, Vol 8(3): 349
Amir M. Salem1, Enas M. Fouad1* and Entsar R Mahdy2
1Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Department of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt
*Corresponding Author: Enas M. Fouad, Department of Pathology, Zagazig University, Zagazig, Egypt, Tel: 01452343123, Email: [email protected]
Received Date: Jun 25, 2018 / Accepted Date: Sep 03, 2018 / Published Date: Sep 11, 2018
Keywords: Serous ovarian carcinoma; SALL4; BECN-1; Grade; Stage; Immunohistochemistry
Epithelial ovarian carcinoma (EOC) is considered the fourth commonest female cancer malignancy [1], and it is considered the commonest cause of postmenopausal cancer related mortality in females worldwide, serous ovarian carcinoma (SOC) is considered the commonest subtype of EOC (Jayson et al.). Despite improvement in the management modalities including surgery, chemotherapy and molecular targeted therapy of SOC it still has a dismal prognosis due to its spread to adjacent organs and through the peritoneal fluid to the peritoneal cavity which leads to late diagnosis at advanced stages and resistance to chemotherapy [2,3]. So discovering novel therapeutic targets will be beneficial to improve its prognosis, decrease rate of its recurrence, decrease the resistance to the currently used chemotherapeutic drugs and could specifically target SOC cells which are main goals of recent clinical cancer studies [4].
Spalt-like transcription factor 4 (SALL4) is the zinc finger transcriptional factor which controls several genes that are involved in normal development, in maintaining embryonic stem cells pluripotency and self-renewal [5], moreover recent studies proved that it has an initiating and promoting roles leukemogenesis and it is found to be over expressed in acute myeloid leukemia cells [6], but its detailed oncogenic roles in several other cancers is not studied yet [7]. Autophagy is considered the homeostatic process that is responsible for recycling of intracellular organelles and foreign substances and it is described as a non-apoptotic process of programmed cells death; autophagy is needed for normal cellular survival and viability [8]. The roles of autophagy in cancer initiation and the carcinogenesis process have been extensively studied [9]. Previous studies stated that autophagy might have a role controlling cancer growth and resistance to chemotherapy. But final proved results of its roles in the carinogenic process are not reached as its exact mechanism of action and its role in cancers is complicated [10], there are plethora of genetic pathways and proteins that are controlling autophagy e.g. Beclin 1 (BECN1) which have been found to have an important inducing role for such process. BECN1 has variable expression levels during cancer progression, which points to the presence of a relation between its tissue protein expression in cancer and the carcinogenic process is considered the human counterpart of yeast Atg6/Vps30, is mapped to the tumor susceptibility locus 150 kb beside BRCA1 gene on chromosome 17q21 [11]. It was originally proved to have a tumor suppressor role in cancer [12]. It was found that BECN1 lower expression could decrease the autophagy activity in malignant cells which has variable effects on cancer progression, invasion and spread according to cancer type [13]. The detailed clinicopathological role of SALL-4 and BECN1 in SOC is not well clarified yet.
To assess the clinic-pathological significance of SALL-4 and BECN1 protein expression in Serous Ovarian Carcinoma tissues, by comparing their expression with standard clinico-pathological prognostic parameters as tumor grade, stage, presence of lymph node and distant metastases.
We have included sixty archival paraffin embedded blocks of SOC which were collected from Pathology Department, Faculty of Medicine, Zagazig University. Cases were previously admitted to Gynaecology and Obstetrics department, faculty of medicine, Zagazig university, cases were managed according to tumor subtype and stage by radical excision of the tumor, we have re-evaluated them, used the International Federation of Gynaecology and Obstetrics (FIGO) staging system for its staging [14], and the WHO grading system for grading sections from all blocks [15]. We have collected all demographic data of patients e.g. age, cancer size, grade, stage, state of lymph nodes, peritoneal fluid, presence of malignant ascites and distant metastasis by examination of patient's and slides files retrospectively in Pathology department.
Immunohistochemical technique and evaluation of both SALL4 and BECN1 expression
Streptavidin-biotin technique were used for immunohistochemistry [16], we have incubated sections with primary Mouse monoclonal anti-Sall4 antibody (ab57577) diluted 1/100 and with primary rabbit monoclonal anti BECN1 Ab1733Y antibody diluted 1/100 at 4°C overnight (Abcam, Cambridge, UK), then with secondary antibody. Last step is counterstaining sections with Mayer's hematoxylin.
Sections from yolk sac tumor were used as a positive control for SALL4 [17] and sections of normal breast tissue were used as positive control for BECN1 respectively, negative control by replacing the primary antibody with usual phosphate-buffered saline (PBS). Degree of immunoreactivity of SALL4 and BECN1 was assessed by 2 senior pathologists from Pathology Department, Faculty of Medicine, Zagazig University.
Brown stain in the nuclei and cytoplasm of SOC cells was considered positive for SALL4 and BECN1 respectively we have given the intensity and extent scores from 0-3 according to the degree of stained cells.
Regarding stain intensity it was graded as 0-negative, 1-weak, 2- moderate and 3-strong stains. Regarding stain extent it was graded as 0 when stained tumor cells were <10%, 1 when stained tumor cells were 10%-20%, 2 when stained tumor cells were 21%-50% and 3 when stained tumor cells were ≥ 50%. We have summated values of both intensity and extent to reach the final scores of 0-6 and we have considered 3 as a cut point for easy statistical analysis; above 3 high expression of both markers and below 3 low expression of both markers [3,18].
All statistics were performed using SPSS 22.0 for windows (SPSS Inc., Chicago, IL, USA). The continuous parameters were presented as mean ± SD, and the categorical parameters were presented as number and percentage using the Chi-square test. The relationship strength between SALL4, BECN1 and clinicopathological parameters of SOC was done by calculating spearman's correlation coefficient.
p-value <0.05 was considered significant statistically.
Patient demographic data were detailed in Table 1.
Mean ± SD 58.53 ± 10.53
Median (Range) 59 (28-78)
<40 years 5 (8.7%)
41-59 years 35 (58.7%)
= 60 years 20 (38.7%)
Positive cytology
Absent 39 (65%)
Present 21 (35%)
=35 U/ml 20 (35%)
>35 U/ml 40 (65%)
Bilaterality
Unilateral 44 (73.3%)
Bilateral 16 (26.7%)
Absent 37 (63.3%)
Present 23 (36.7%)
Low 24 (38.3%)
High 36 (61.7%)
Node negative 23 (35%)
Node positive 37 (65%)
M0 (non-metastatic) 45 (76.7%)
M1 (metastatic) 15 (23.3%)
FIGO Stage
Stage IA 2 (3.3%)
Stage IB 3 (1.7%)
Stage IC 3 (3.3%)
Stage IIA 3 (5%)
Stage IIB 7 (11.7%)
Stage IIC 6 (10%)
Stage IIIA 8 (15%)
Stage IIIB 11 (20%)
Stage IIIC 4 (6.7%)
Stage IV 13 (23.3%)
SALL4
Low 25 (46%)
High 35 (64%)
Beclin-1
Table 1: Demographic and immunohistochemical data
We have included 60 cases of SOC of variable grades and stages. Age of our patients ranged from (28-78) years and the age is: 58.53 ± 10.53years. 36 (61.7%) cases are diagnosed with high grade tumors while 24 (38.3%) cases are diagnosed with low grade SOC, lymph node metastases are present in 37 (65%) cases and distant metastases are present in 15 (23.3%) of our cases.
SALL 4 expression in SOC and its correlation with clinicopathological parameters
High SALL4 expression was found in 35 (64%) of cases and its high expression was significantly positively correlated with advanced age of the patients (p=0.003), higher grade of the tumor, advanced stage of the tumor (p<0.001), presence of distant metastases, positive peritoneal cytology (p=0.006), peritoneal implants (p=0.002), L.N metastases (p=0.004), and presence of malignant ascites (p=0.024), no statistically detected difference between its expression and bilaterality of the tumor (Table 2, Figure 1).
(60 cases)
Mean ± SD 58.53 ± 10.53 47.54 ± 10.10 60.15 ± 7.68 <0.001*
Median (Range) 59 (28-78) 45 (25-65) 59 (46-75)
<40 years 5 (8.7%) 4 (100%) 0 (0%) 0.003‡
41-59 years 35 (58.7%) 16 (44.1%) 18 (55.9%)
≥ 60 years 20 (33.7%) 5 (13.6%) 17 (86.4%)
Absent 36 (65%) 21 (53.8%) 15 (46.2%) 0.006‡
Present 24 (35%) 4 (4.8%) 20 (95.2%)
≤35 U/ml 20 (35%) 17 (81%) 3 (19%) <0.001‡
>35 U/ml 40 (65%) 8 (12.8%) 32 (87.2%)
Unilateral 44 (73.3%) 19 (40.9%) 25 (59.1%) 0.258‡
Bilateral 16 (26.7%) 6 (25%) 10 (75%)
Absent 37 (63.3%) 21 (52.6%) 16 (47.4%) 0.002‡
Present 23 (36.7%) 4 (9.1%) 19 (90.9%)
Present 23 (36.7%) 6 (18.2%) 17 (81.8%)
Low 24 (38.3%) 21 (78.3%) 3 (21.7%) <0.001‡
High 36 (61.7%) 4 (10.8%) 32 (89.2%)
Node negative 23 (35%) 20 (81%) 3 (19%) 0.004‡
Node positive 37 (65%) 5 (12.8%) 32 (87.2%)
M0 (non-metastatic) 45 (76.7%) 21 (45.7%) 23 (54.3%) 0.006‡
M1 (metastatic) 15 (23.3%) 4 (7.1%) 12 (92.9%)
Stage IA 2 (3.3%) 2 (100%) 0 (0%) <0.001§
Stage IB 3 (1.7%) 3 (100%) 0 (0%)
Stage IC 3 (3.3%) 3 (100%) 0 (0%)
Stage IIA 3 (5%) 3 (100%) 0 (0%)
Stage IIB 7 (11.7%) 5 (71.4%) 2 (28.6%)
Stage IIC 6 (10%) 4 (66.7%) 2 (33.3%)
Stage IIIA 8 (15%) 1 (11.1%) 7 (88.9%)
Stage IIIB 11 (20%) 2 (16.7%) 9 (83.3%)
Stage IIIC 4 (6.7%) 1 (25%) 3 (75%)
Stage IV 13 (23.3%) 1 (7.1%) 12 (92.9%)
Low 38 (58.3%) 5 (5.7%) 33 (94.3%) <0.001‡
High 22 (41.7%) 18 (80%) 3 (20%)
Table 2: Correlation between clinicopathological features and immunohistochemical expression of SALL-4 in our cases (*Independent samples Student's test; ? Mann Whitney U test; ‡Chi-square test; §Chi-square test for trend; p
Figure 1: Immunohistochemical expression of SALL4 serous ovarian carcinoma (SOC): (A) High nuclear expression in high grade SOC Stage IV 400X. (B) High nuclear expression in high grade SOC Stage III 400X. (C) Low nuclear expression in low grade SOC Stage II 400X.
BECN1 expression in SOC and its correlation with clinicopathological parameters
High BECN1 expression was found in 38 (65%) of cases and its high expression was significantly negatively correlated with advanced age of the patients (p=0.003), higher grade of the tumor, advanced stage of the tumor, L.N metastases, presence of distant metastases, peritoneal implants (p<0.001), positive peritoneal cytology (p=0.004), bilaterality of the tumor (p=0.020) and presence of malignant ascites (p=.006) (Table 3, Figure 2).
BECN1
Mean ± SD 55.53 ± 10.53 61.20 ± 7.23 47.60 ± 9.28 <0.001•
<40 years 4 (6.7%) 0 (0%) 4 (100%) 0.003‡
≥ 60 years 22 (36.7%) 22 (86.4%) 2 (13.6%)
Absent 36 (65%) 14 (35.9%) 22 (100%) 0.004‡
Present 24 (35%) 24 (100%) 0 (0%)
≤ 35 U/ml 20 (35%) 3 (14.3%) 17 (85.7%) <0.001‡
>35 U/ml 40 (65%) 35 (82.1%) 5 (17.9%)
Unilateral 44 (73.3%) 24 (50%) 20 (50%) 0.020‡
Bilateral 16 (26.7%) 14 (81.3%) 2 (18.8%)
Absent 37 (63.3%) 16 (36.8%) 21 (63.2%) <0.001‡
Present 23 (36.7%) 22 (95.5%) 1 (4.5%)
Present 23 (36.7%) 21 (81.8%) 2 (18.2%)
Low 24 (38.3%) 6 (13%) 18 (87%) <0.001‡
High 36 (61.7%) 32 (86.5%) 4 (13.5%)
Node negative 23 (35%) 8 (14.3%) 15 (85.7%) <0.001‡
Node positive 37 (65%) 30 (82.1%) 7 (17.9%)
M0 (non-metastatic) 45 (76.7%) 23 (45.7%) 22 (54.3%) <0.001‡
M1 (metastatic) 15 (23.3%) 15 (100%) 0 (0%)
Stage IA 2 (3.3%) 0 (0%) 2 (100%) <0.001§
Stage IB 3 (1.7%) 2 (3.3%) 1 (100%)
Stage IC 3 (3.3%) 1 (1.6%) 2 (100%)
Stage IIA 3 (5%) 0 (0%) 3 (100%)
Stage IIB 7 (11.7%) 0 (0%) 7 (100%)
Stage IIC 6 (10%) 4 (60%) 2 (50%)
Stage IIIB 11 (20%) 9 (75%) 2 (25%)
Stage IV 13 (23.3%) 13 (100%) 0 (0%)
SALL-4
Table 3: Correlation between clinicopathological features and immunohistochemical expression of BECN1 in our cases (*Independent samples Student's test; •Mann Whitney U test; ‡ Chisquare test; § Chi-square test for trend; p
Figure 2: Immunohistochemical expression of Beclin-1 in serous ovarian carcinoma (SOC): (A) High cytoplasmic expression in low grade SOC Stage I 400X. (B) High cytoplasmic expression in low grade SOC Stage II 400X. (C) Low cytoplasmic expression in high grade SOC Stage IV 400X.
We found an inverse relationship between SALL4 and BECN1 (Spearman's r=-0.198) (p=0.031) (Table 4).
SALL4/BECN1
(Low, high)
(Low/low……..high/high)
Age (years) 0.602 <0.001 -0.501 <0.001 -0.718 <0.001
FIGO stage (IA, ………,IV) 0.873 <0.001 -0.588 <0.001 -0.701 <0.001
Grade (low, high) 0.667 0.001 -0.528 <0.001 -0.544 <0.001
LN (negative, positive) 0.64 <0.001 -0.446 <0.001 -0.563 <0.001
DM (negative, positive) 0.485 0.006 -0.578 0.001 -0.653 <0.001
SALL4 (low, high) --- --- -0.198 0.161 --- ---
BECN1 (low, high) -0.198 0.161 --- --- --- ---
Table 4: Association and correlation between clinicopathological parameters, SALL4 and BECN1 in our cases (r correlation coefficient; p
We found that high SALL4 expression was found in 35 (64%) of cases and its high expression was significantly positively correlated with advanced age of the patients (p=0.003), higher grade of the tumor, advanced stage of the tumor (p<0.001), presence of distant metastases, positive peritoneal cytology (p=0.006), peritoneal implants (p=0.002), L.N metastases (p=0.004), and ascites (p=.0.024). Yang et al. [19] have found similar results in SOC, similarly, results of previous studies regarding the association between SALL4 and poor prognosis of multiple solid tumors [20-23].
So, our results proved that increased tissue protein expression of SALL4 could increase migration, proliferation, invasion and metastatic potential of SOC cells which pointed to that SALL4 is a cancer promoting agent which might be used as novel therapeutic molecular target for improving management modalities of SOC.
The explanation of our results is provided by Zeng et al. [24] who stated that SALL4 has an essential role in regulation of cancer stem cells proliferation which is responsible for high proliferation rate, invasion and metastases of cancer, additionally it was found that inhibition of SALL4 could result in down-regulation of stem cell markers, in addition to decreasing the invasion potential of cancer cells [17], SALL4 has many other roles in tumor promotion and progression as it could interact with b-catenin which results in aberrant activation of Wnt/b-catenin signaling pathway that have major roles in increasing cancer cells invasion, lymph node and distant metastasis [17]. Moreover SALL4 is found to be involved in c-Myc, HOXA9, and PTEN-AKT pathways, which are responsible for activation of the epithelial-mesenchymal transition (EMT) [21,25]. The process of EMT has an important role in increasing spread of SOC [26,27]. Our results are similar to results of Liu et al. [28] who proved that increased SALL4 expression is related to poor prognosis of endometrial carcinoma and explained his results by the association of SALL4 expression and chemoresistance to the currently used chemotherapeutic drugs in endometrial carcinoma, similarly other studies have proved that SALL4 could induce chemoresistance and poor prognosis in many cancers [29]. As chemotherapy has major role in management of SOC the induction of chemoresistance markedly worsen its prognosis. The role of SALL4 in drug resistance is explained by that drug resistance in cancer is associated with ATP-binding cassette (ABC) which is multidrug transporters, SALL4 could induce chemotherapeutic resistance by regulation of ABCB1 in cancer cells. ABC are closely related to drug resistance and ABCB1 which is the prototype of this family of genes, and its dis-regulation is related to drug resistance in cancers of several organs [28]. Another explanation for the association between SALL4 and poor prognosis in cancers is due to its ability to promote c-Myc transcriptional activity which has many roles cancer drug resistance, invasion and metastasis [25].
Our results are similar to results of Du et al., who proved the upregulation of SALL4 by EGFR activation that could be able to regulate the stemness of CD44-positive cells in lung cancer [30]. In addition to its role in cancer progression several other functions e.g. Yang has found that SALL4 is a transcriptional and epigenetic regulator in normal and leukemic hematopoiesis [31].
Our study proved that anti- SALL4 drugs could specifically target SOC cells and could decrease its invasion, spread and improving its prognosis.
To strengthen our results we have tried to find the association between SALL4 and BECN1 which is an autophagy marker and find the effect of their combined expression on the prognosis of SOC. In this study we have found that increased tissue BECN1 expression in SOC was associated with favorable clinic-pathological parameters. High BECN1 expression was found in 38 (65%) of cases and its high expression was significantly negatively correlated with advanced age of the patients (p=0.003), higher grade of the tumor, advanced stage of the tumor, L.N metastases, presence of distant metastases, peritoneal implants (p<0.001), positive peritoneal cytology (p=0.004), bilaterality of the tumor (p=0.020) and presence of malignant ascites (p=0.006).
BECN1 role in oncogenesis has taken attention it is found to be overexpressed in many cancers while down regulated in other cancers [32], so BECN1 might have variable roles in cancer according to cancer type. Autophagy has variable roles in cancer initiation, promotion and progression which is different according to type of cancer as it may have an inhibitory effect on cancer by maintaining genomic stability or a stimulatory effect by acting as a pro-survival signal which protects malignant cells from any cellular stress [32]. Recently BECN1 which is an autophagy related regulatory protein has been found to be down regulated in many cancers and this is considered recent evidence which linked autophagy to malignant suppression [33].
Similarly, Cai et al. [33] found that increased BECN1 expression is associated with high degree of ovarian cancer differentiation suggesting that BECN1 might behave as a protective factor in cancer ovary. Additionally, Osman et al. [34] have proved the association between BECN1 expression and high degree of differentiation in HCC, and its expression was negatively associated with unfavorable clinicopathological criteria and poor prognosis in HCC, additionally, Wu et al. [35] have proved similar results in cancers of many organs. Results of our study in addition to results of previous researchers declared that BECN1 acts as a tumor suppressor gene that decreased aggressively of cancer.
Moreover, Ying et al. [3] assessed the relations between BECN1 expression and response to chemotherapy; they have found that its expression was higher in drug sensitive ovarian cancer patients than in drug resistant patients, which proved that decreased BECN1 expression is associated with chemoresistance resistance and dismal outcome in ovarian carcinoma patients.
We proved that BECN1 high expression was found in early stage SOC than the late stages; similarly, Fei et al. [36] found increased BECN1 expression in early stages of cancer stomach than in late stages.
Such results are explained by that tissue protein expression levels of BECN1 have decreased with cancer progression as cancer cells lose the autophagy capacity during cancer progression, escape cell death and become more liable for invasion, spread and more aggressive behavior [36]. Miracco et al. [37] assessed BECN1 protein expression in atypical meningioma and ependymal high-grade neoplasms and they have proved decreased its expression in high grade than in low grade tumors, that points to that decreased BECN1 expression is associated with more aggressive brain tumors, which was similar to our results in SOC.
Results about role of BECN1 in cancer and its association with good prognosis in SOC is unproved yet, as different results were found by Zhao et al. [38] who concluded that BECN1 has no relation to ovarian carcinoma prognosis these results might be explained by different number of cases and different clone of the primary anti-BECN1 antibody that was used in the study.
Other studies which declared similar results; Cai et al. [33] found that high increased tissue protein BECN1 expression is associated with favorable outcome in SOC patients. Many theories were put to explain their results (1) BECN1 increased autophagy in ovarian carcinoma cells that are lacking apoptotic ability leading to their death and decreasing their survival; (2) BECN1 decreased the occurrence of gene mutations by stabilization of the mitochondrial structure so decreased emergence of aggressive, invasive and metastasizing clones (3) Increased BECN1 expression stops the completion of cell cycle, so inhibits cancer cell proliferation, stimulates autophagy and apoptosis (4) Moreover BECN1 delays cell cycle progression [33]. Moreover, high BECN1 expression leads to increased phosphorylation of p53 and Bcl-2 [39], and caspase-9 activity [40], which enhanced autophagy related cell death Dong et al. [41] proved the protective roles of BECN1 in many cancers, which was similar to our work.
Other studies have proved different results regarding the association between BECN1 expression and cancer prognosis. Contrast to our results, Wan et al. [42] and Tang et al. [43] proved the association between high BECN1 expression and aggressive tumor behavior in nasopharyngeal carcinoma a and in squamous cell carcinoma, which is explained by differences in the intrinsic properties of each cancer.
Shi et al. [44] have stated that BECN1 down regulation in hepatocellular cancer lead to increased antiapoptotic Bcl-XL expression, which allows increase hepatocellular carcinoma cells survival. The interaction between BECN1 and Bcl-XL inhibits autophagy and promotes the cancer progression.
Also more recent study by Zhao et al. have proved the role of BECN1 and LC3 as predictive biomarkers for metastatic colorectal carcinoma which was similar to our results [45].
We have found an inverse relationship between SALL 4and BECN1 (Spearman's r=-0.198) (p=0.030).
We have proved negative correlations between SALL4 and BECN1 expression as SALL4 increased SOC progression, invasion and spread by inducing EMT and activation of Wnt/b-catenin signaling pathway, while BECN1 expression is related to favorable outcome due to increased autophagy and decreased emergence of aggressive subclones, moreover SALL4 expression was related to resistance to chemotherapy which leads to SOC progression, so therapeutic targets against both SALL4 and BECN1 can be beneficial recent management modalities for SOC.
It is recommended to do a prospective large scale study on larger number of patients to clarify detailed molecular roles of SALL4 and BECN1 in progression and spread of SOC.
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Citation: Fouad E, Salem A, Mahdy E (2018) Clinicopathological Significance of SALL4 and BECN1 Tissue Protein Expression in Serous Ovarian Carcinoma (SOC); An Immunohistochemical Study. J Clin Exp Pathol 8: 349. DOI: 10.4172/2161-0681.1000349
Copyright: © 2018 Salem AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Students protest housing decision
About 150 students participated in an orderly two-hour sit-in outside President Charles M. Vest's office Friday afternoon to protest the decision to house freshmen on campus starting in 2001. The demonstration was organized by MIT Choice, a student group formed in September.
The students, who carried signs and chanted "Choice/Not Change," convened in Lobby 7 at 12:30pm and marched upstairs one flight to Building 3 about 15 minutes later. They sat against both walls in the corridor outside the President's offices.
"While the participants do not feel that the housing system is without flaw, they do not support a change which would severely limit the diversity of residence options for students," MIT Choice said in a press release.
While there, the students exchanged views with Chancellor Lawrence Bacow, Professor (and President Emeritus) Paul Gray, Chair of the Faculty Steven Lerman and Dean for Student Life Margaret R. Bates before dispersing. Others at the event included Associate Deans Kirk Kolenbrander and Kim Vandiver, and Paul Parravano of the Office of Government and Community Relations.
President Vest was not in his office during the sit-in.
A version of this article appeared in MIT Tech Talk on November 10, 1999.


One of the advantages of joining the older demographic is that occasionally we get asked to speak at palliative care study days in interesting places across the world.
The irony is that rather than teaching others, such experiences invariably lead to opportunities to learn as our pre-conceptions are challenged. We experience new ways of thinking and applying palliative care principles in contexts and cultures which are very different from the world of Dame Cicely in South East London. There is much to learn and consider.
Hong Kong is a place of contrasts, cultures and political and historical sensitivities. It is one of the busiest, wealthiest and most active cities on the planet. Part of China's Pearl River Delta Economic Zone, which is the fastest growing mega city of the fastest growing province in the fastest growing large economy in the world, Hong Kong retains a distinctive connection with the UK alongside its ties to the mainland.
Hong Kong has more Rolls Royce cars per head of population and more high-rise buildings (7685) than any other city on earth. Yet, despite its wealth and success there is a tendency to downplay the success of local achievements.
I was brought up to understand that traditionally many Chinese people regarded death as taboo. Discussions around death are associated with bad luck and to be strictly avoided. Many of the high-rise buildings still avoid naming fourth floors as the word for four and death are similar. However this traditional taboo is rapidly changing.
The recent death of the father of fibre optic communications, Professor Charles Kao, from dementia in a nursing home provoked widespread discussion across media and social media outlets.
This discussion would have been unheard of even a few years ago. Professor Kao, who had witnessed the medicalisation of his own father's death, had made it clear that when his time came he did not want to be actively kept alive.
That such a prominent citizen should have expressed such views really promoted much discussion in a country where 90 percent of people die in hospital and where the possibility to die outside of hospital is hampered by rigid legal and policing reporting demands.
Traditional views are being challenged as the Hong Kong "twitterati" grapple with what constitutes a good death and whether dying needs to be a medical process.
With a growing elderly population, widely scattered families and the mixed public private health infrastructure under real pressure, there is a growing hunger to discuss such matters and overcome the reticence of previous generations.
Palliative care services in Hong Kong are now well established since their initiation in 1982, though the pressure on palliative care teams is intense.
Tuen Mun Hospital has almost 2,000 beds, but regularly has an occupancy of 130% due to the pressures from the surrounding population. Yet despite the pressures of such an active acute hospital, the palliative care team are very well integrated across the hospital's different services and their advice and input is sought daily.
The hospital palliative care study days were attended by a wide range of staff from across the hospital. This demonstrates how well regarded the team have become, and how much their holistic input is appreciated.
There are 43 inpatient palliative care beds within the hospital and an outpatient and day hospice service for the never ending flow of patients and families in need.
The main areas of liaison work across the hospital involve helping to manage challenging symptoms and in support for difficult conversations with patients and families.
Tuen Mun is the first hospital I have seen which has its own dedicated Palliative Surgical ward. This unit, comprising eight beds provides palliative and supportive care to patients with surgical problems for whom surgery is not aimed to cure.
The improved mortality and morbidity data shows how significant this innovation has been and poses the question as to whether such units should not be in place wherever post-op data shows that the wrong people are being operated on.
Such innovation and the commitment and energy of the palliative care team in Tuen Mun is truly inspiring. By bringing their unique palliative care approach to patients and families in a manner sensitive to the nuances of Hong Kong the team are modelling an approach and a service which could have a profound impact across the whole of China. Truly there is much to learn and consider.


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Jeremy Utley
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Jeremy leads the d.school's work with organizations as the Director of Executive Education. In this role, he advises professionals and organizations on how to imbed the tools of design thinking and cultivate an innovative organizational culture. He also teaches two celebrated courses -- d.leadership and LaunchPad -- advanced offerings focused on creating real-world impact with the tools of design. He is also the host of the d.school's "Masters of Creativity" series.
Jeremy speaks and writes extensively on the history of invention, discovery, creativity, and innovation.
Jeremy never expected to be a designer. On his 10th birthday, his father asked him what he wanted to be when he grew up. Jeremy replied,"I want to be one of the people who carry boxes with handles." A little over a decade later, Jeremy became a briefcase-carrying management consultant focusing on economic development. Then, in 2008, the d.school derailed him completely. His time as a student and a fellow at the d.school showed him that "how" he worked was more important than "what" he did. Today, Jeremy is dedicated to helping others along the same path to becoming a designer. He helps people change their deeply-engrained behaviors and discover, as he did, that it is possible for them to make a difference. He does this through teaching as well as through growing alongside his students to become better in his own life and work every day.
Jeremy is the Director of Executive Education at the d.school. He is a graduate of The University of Texas at Austin's Red McComb's School of Business (2005) and the Stanford University Graduate School of Business (2009).
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Businesses to be verified based on new B-BBEE Code Amendments from 01 December
ENGINEERING NEWS / 05 NOVEMBER 2019 - 13.47 / STAFF REPORTER
Companies verified after 01 December will be audited based on the newly implemented, Amended B-BBEE Codes. With less than one month left to realign compliance strategies, companies are strongly advised to factor these Amendments into their plans from 01 December.
According to Tirhani Ngobeni, Senior Transformation Consultant for LFP Group, the Amendments highlight government's emphasis on B-BBEE as well as the country's zero-tolerance policy around non-compliance. "B-BBEE compliance is no longer a 'nice to have' and businesses who do not comply will feel the pinch" she says.
"These Amendments can greatly impact your scoring. Businesses who do not comply are at risk of a losing (or lowering) their current B-BBEE status,"
Amendments were proposed on 31 May 2019 and look to address outstanding issues and reduce Gazetting costs. "There is a host of vital Amendments which will affect companies' Enterprise and Supplier Development, Skills Development and Ownership Flow-Through Principles. In addition, Interpretations and Definitions have been Amended including those under Absorption".
Tirhani believes that the changes help to clarify the confusion that has long plagued corporate SA. "Like with everything, further precautionary measures and clarifications around the B-BBEE Charter need to be put in place – regardless of some of the controversy that surrounds them,"
"President Cyril Ramaphosa continues to rally behind B-BBEE, and businesses are playing close attention" she explains.
Key Amendments to Note:
Tirhani notes that various changes have been implemented to further promote the support of black-owned enterprises in South Africa.
"One of the biggest changes to note is Procurement Spend with 51% Black Owned Businesses. Here, points have increased from 9 to 11 and the target from 40 – 50%. Amongst other notable changes, is that the multiplier of 1.2 (for first time suppliers) is removed and replaced by a 1.2 recognition boost for purchasing from 51% Black Owned or Black Woman Owned suppliers. These qualifications are achieved using the flow-through principle".
Some of Amendments to note under Skills Development is that of absorption, for instance, which no longer includes further education and training and affects the 5 Skills Development bonus points. "The points available under Skills Development and bursary expenditure now sit at 10 (up from 8) while the combined target remains at 6%".
Tirhani further notes that 'double counting' of initiatives under Skills Development expenditure and bursaries is not permitted and that the 40% sub-minimum for Priority Element compliance is clarified as 8 points. "Formal Skills Development expenditure is extended to include Category A bursary students so companies can now claim stipend expenditures for Categories A, B, C and D learners which will prove beneficial".
"Training Manager's salary cannot exceed 15% of your Skills Development Expenditure" she explains.
Tirhani urges businesses to implement the required changes within their companies in-line with reputable B-BBEE service providers. "Understanding the Amendments and how to implement them is crucial to a business's success".
LINK : http://www.engineeringnews.co.za/article/businesses-to-be-verified-based-on-new-b-bbee-code-amendments-from-01-december-2019-11-05/rep_id:4136
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"Perfect Situation" is a song by American alternative rock band Weezer. It was released to radio on October 11, 2005 as the third single from the band's fifth album Make Believe, following "Beverly Hills" and "We Are All on Drugs".

The song is also one of the band's most successful songs to date, topping the Billboard Modern Rock Tracks for four weeks, outlasting the one-week run atop the chart of "Beverly Hills", although it didn't gain the former's massive pop success, reaching #51 on the Billboard Hot 100.

Radio edit
The radio edit of this song features a shortened intro, a synth track on the first and second chorus (the album version only has it on the second chorus), a reworked "oh-oh" chorus and the added backup vocals of "perfect situation" over the outro. The radio edit is eight seconds shorter than the album version. The reworked chorus that appears in the radio edit was one of two ways Cuomo originally wrote the song. When touring in summer 2005, when the band prompted the crowd to sing along, they oddly enough sang it in the other way Cuomo had written it (different from the record version). Cuomo stated in an interview during the band's 2005 performance at the AOL Sessions as saying "Well, if these ten thousand people think it should go this way, maybe we should go back and re-record it."

The alternate version was put on later pressings of the album with the full intro, reworked chorus and outro.

Music video
The video, directed by Marc Webb, premiered on November 11, 2005, and features actress Elisha Cuthbert as the lead singer of Weeze, a fictional predecessor to Weezer, who is eventually replaced by actual frontman Rivers Cuomo. The video also features a cameo by the band's webmaster/band photographer/archivist and longtime close friend Karl Koch and like the "Beverly Hills" video, the band invited actual Weezer fans via casting call to be in the video's crowd scenes. A new cover for Make Believe was created for the video of Perfect Situation, replacing Cuomo with Cuthbert, as well as showing the fictional name "Weeze".

Chart performance

Weekly charts

Year-end charts

Personnel
Rivers Cuomo – lead vocals, lead guitar, keyboards
Brian Bell – rhythm guitar
Scott Shriner – bass guitar
Patrick Wilson – drums, percussion
Rick Rubin – production

References

External links
Lyrics for "Perfect Situation"

Weezer songs
2005 singles
Songs written by Rivers Cuomo
Song recordings produced by Rick Rubin
Music videos directed by Marc Webb
2004 songs

redpajama_set_name: RedPajamaWikipedia


UNC's multidisciplinary breast cancer program has been a thriving example of true multidisciplinary care for the past 15 years. Unlike many programs that have multidisciplinary tumor boards that meet to review cases after treatment decisions have been made, UNC takes a true "team approach". Patients are seen on the same day as the tumor board by all disciplines, and the multidisciplinary treatment recommendations are made by the group. This allows co-ordination of treatment care, consensus recommendations, and fosters interdisciplinary treatment trials.
LCCC0411: This trial follows on Dr. Sartor's laboratory studies of the EGFR/HER2 inhibitor, lapatinib (Tykerb), that indicate that lapatinib may be an effective radiosensitizer for locally advanced breast cancer. It is a Phase I study for patients with locally recurrent breast cancer (prior radiation allowed) that tests the dose of lapatinib that is tolerated with radiation. An important aspect of the trial is that samples of the tumor are obtained to study the biological basis of how lapatinib makes breast cancer more sensitive to radiation.
LCCC0218: This trial is for patients with very favorable early stage breast cancer, and tests whether a single dose of radiation delivered at the time of surgery in the operating room (intraoperative radiotherapy or IORT) is effective and well tolerated. The goal of this Phase II study is to determine the feasibility of decreasing the radiation therapy from 5-6 weeks to a single day. An important aspect of this trial is that samples of the tumor are obtained before and after irradiation to study how radiation affects breast cancer at the molecular level.


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Sophia Stoyanovich
Bio courtesy of Sophia Stoyanovich
Hailed as "…a spectacular young violinist" by Seattle Times Music Critic Bernard Jacobson, American-born violinist Sophia Stoyanovich has captivated audiences since her premiere at age ten with the Bremerton Symphony. She has soloed with numerous orchestras including highlights with the Seattle Symphony at Benaroya Hall, and has performed across North America, Europe, Russia, China and Vietnam. Recent highlights include prizes at the Les Musicales du Centre Paris Competition and Vršac International Music Competition, featured artist on The Chamber Music Society at Lincoln Center's Masterclass Series, Classical King FM's Northwest Focus Live, and the University of Washington Women's Society Recital Series. Upcoming engagements for 2020-2021 season include debuts with the Santa Monica College Symphony, Dame Myra Hess Memorial Concert Series, Crocker Art Museum Concert Series, and travels to Athens, Greece for performances with Leonidas Kavakos as part of the 2021 International Violin Masterclass Series.
Ms. Stoyanovich presented her first professional solo recital for the Collected Works Concert Series at age twelve, and continues as a frequent recitalist in New York City and at home in Seattle, Washington. Ms. Stoyanovich received Gold Medal at the 2016 New York International Virtuosi Competition, and nominated Audience Prize at the 2018 Frances Walton Competition. This past summer she won 1st place at the New York Golden Classical Competition with an invitation to perform at Weill Recital Hall at Carnegie Hall. In addition, Ms. Stoyanovich was a semi-finalist at the 2019 Ysaye International Competition in Liège, Belgium and 2019 Harbin International Violin Competition in China.
Ms. Stoyanovich's firm belief in community engagement has influenced her identity as an artist. In March of 2014, Ms. Stoyanovich traveled to Vietnam where she hosted masterclasses and performed for students in Hoi An, Da Nang, and Ho Chi Minh City, as a traveling artist with the About Face Foundation. She has in addition collaborated with NPR's From The Top as soloist and active community member, working with students throughout the Washington state area. Most recently, Ms. Stoyanovich has produced a new podcast series entitled American Stories. A collaboration with long-time friend and fellow Juilliard-alumni, Derek Wang, American Stories celebrates American concert music in all its diversity as a mirror to the stories of people living in our country today.
An avid chamber musician, Ms. Stoyanovich serves as Communications Director and violinist of The Versoi Ensemble, which had its November 2018 New York debut at Merkin Hall reviewed to much acclaim by New York Classical Review and The Strad Magazines. The Versoi Ensemble toured Finland in August of 2019 and will return for their tour of the USA next season, pursuing their belief in international cultural diplomacy through chamber music. Ms. Stoyanovich is also a representing artist on the Bailu Music Artists Roster as of 2019.
The daughter of Pacific Northwest-based composer Patrick Stoyanovich, Ms. Stoyanovich's passion for the modern music of our time has influenced her collaboration on several world premieres with mezzo-soprano, Sarah Mattox, and The St. Cecilia Music Festival including commissioned works, "Cantos de San Juan de la Cruz", and songs of "Saint Thomas Aquinas" by Patrick Stoyanovich. Ms. Stoyanovich premiered Patrick Stoyanovich's 'Shiloh' Quartet at the Bowery Poetry Society in October of 2016. She continues to collaborate with composers across the country and currently is commissioning works for her series, American Stories.
Ms. Stoyanovich currently performs with Symphony in C and The Montclair Orchestras, and has attended the Barenboiem-Said Akademie and Kronberg Masterclasses in Germany, the International Musicians Seminar at Prussia Cove, Schleswig-Holstein Musik, and Sarasota Music Festivals. She was a Fellow at the Aspen Music Festival, National Youth Orchestra of the United States, Marrowstone Music Festival, Indiana University String Academy, and Interlochen Arts Academy.
Ms. Stoyanovich has participated in numerous masterclasses including working with András Keller, Noah Bendix-Balgley, Chaim Taub, Ida Kavafian, Gil Shaham, Daniel Hope, Robert Chen, Sheryl Staples, Tjeerd Top, and Donald Weilerstein.
Ms. Stoyanovich received her Bachelor and Masters of Music degrees from The Juilliard School under the tutelage of Li Lin, as recipient of the Irene Diamond Graduate Fellowship and the Drs. & Kassie Biros Neuman Scholarships. She performs on a 1930 Berger Violin made in New York City.


SatinGlide® Metal-Front Racks Provides smooth movement even on fully loaded racks. The metal front gives the racks a bold, high-end design.
Stainless Steel Cabinet and Base Grille Combines the durability and beauty of stainless steel on the exterior, enhancing and matching the look of the cabinet door.
Glass shelf/shelves with metal trim Are a worry free way to store and locate your favorite beverages and other food items. These metal front shelves can easily be cleaned and stop spills from spreading in the refrigerator.
Love love love this!! Not only is it functional, it's absolutely beautiful! So happy I purchased this!
Perfect addition to our kit Reno!
They delivered the unit with a damaged door mid-February and since we have been waiting to get the door replaced. So far they have shipped 3 replacement doors which all have been damaged.
So much better than the unit I replaced.
My favorite appliance in the kitchen! It holds eight bottles of wine and plenty of soda both cans and bottles. It is quiet and we like when you walk by the center, the light inside automatically comes on. Great purchase!
We just had this installed as part of our kitchen/butler's pantry remodel so I have only had it for a couple of days. I love that has preprogramed temperatures on it for wines so it is easy to change based on what you are adding to the beverage center. I also like the slide out wine bottle holders. Ours is mainly used as a second refrigerator, something the kids can easily get in and out of without standing at the main refrigerator with the door open. They can see in and pick the flavor of water they want before opening and wasting energy. I will say it is an expensive refrigerator to be used as a second refrigerator but I think in the long run it will be worth it. It has a decent amount of storage space. The auto light function is pretty cool too. It goes on when you open, stays on for a brief period, then dims to off. The downfall is that there is not a moveable shelf. That would have been a nice feature to have. Overall it is a nice piece, but a little expensive.
I've bought this and had it installed about 5 months ago. The fridge has great capacity and we fill it with tons of variety of soft drinks, water, perrier etc. The bottom rack is perfect for storing our wine bottles and the tempature control is perfect for keeping the soft drinks cool while keeping the wine at the perfect temperature. The light feature is also really neat where it lights up whenever someone passes by the fridge or the door is opened. One improvement noted was - if you over fill the fridge, the soft drinks in cans can freeze and then explode will in the fridge. This has happened already twice where we came home to find the fridge door opened with some cans fallen on our floor / spills. Would be good if this fridge had some sort of lock on it so that the door doesnt open so easily. We've been filling it with less items so that the last can isnt touching the back of the fridge to prevent this. Overall, it's a beautiful fridge which everyone has commented on how neat it looks and operationally functional it is.
This has been our worst appliance purchase ever. The dual temperature zone is a joke. When the upper is set for 37 degrees and lower is set for red wine at 64, the lower zone cannot get above 50 degrees. After a long and torturous experience navigating the maze of KitchenAid customer service, and 3 attempted repairs over the course of 3 months the unit was finally replaced. After all this, the new unit works exactly like the previous one!!!
Great with dual zones- one cool for beer and soda and a less cook for white wine and champagne. Only complaint being that the door needs a gentle to stay closed.
I love the interior light and look of this under-counter refrigerator. It has been great for wine and beer, and I appreciate the different temperature settings in different zones.
We are very happy with our purchase and even had to have a custom butler's pantry to feature our awesome beverage center. We have been enjoying cold refreshments. It looks great freestanding also and have received compliments on high end product. We had been researching for a couple of years and glad we got this model.


This sign focuses on the month of March, which follows Black History Month in February, and so even though black people are not explicitly named here, they are clearly the individuals supposedly making "bad choices." In other words, the sign is sending the message that white people make good choices, which lead to their success, and black people make bad choices, which prevent them from being successful. What a convenient explanation for racial inequality! This defense of personal responsibility absolves all systems from perpetuating inequality and focuses on the narrative that racism is a thing of the past, that the American dream of hard work leading to success is alive and well. If only that were true, but unfortunately this is a very damaging and powerful myth that white people are taught to believe. The more white people believe this myth, the more they perpetuate it, which protects the status quo and the power of the small, wealthy white elite.
In New Jersey, white people have been indoctrinated to believe since we're in the North, we're the "good guys." Moreover, since we're such a racially diverse state, we are also indoctrinated to ignore the racial segregation that makes our state one of the most racially segregated in the entire country.
For those white people who consider themselves successful, many believe that they are successful because of their own individual hard work. It is very hard for white people to acknowledge the unearned advantages that they benefit from. These unearned advantages include financial benefits our parents and grandparents accessed, like low interest mortgages and housing, that often got passed to us through intergenerational wealth. Today, these unearned advantages include being much less likely to get funneled into a school-to-prison pipeline, to be pulled over, to be arrested, and to be followed in a store, and much more likely to be presumed innocent, to have a resume reviewed, and to see people who look like us in positive and affirming roles in TV, film, and the news media.
For those white people who are unemployed, in minimum wage jobs, and/or unable to access the resources they need, many believe that individual people of color and immigrants have stood in their way, gotten their job, or taken their spot, as if it is all a zero-sum game. This belief, like the belief of white people who attribute their success to their hard work, both deny systemic racism.
Systemic racism did not always exist. It was invented. Whiteness was invented. Most white people don't know this history because we are not usually taught this history. Whiteness, and race in general, is an invention. It is not natural or biological. "White" is a category that was created for the purposes of power and control, of divide and conquer. "White" was invented to bestow humanity upon one group of people and to divide them from other groups of people, people of color, especially black people and indigenous people, who were identified as sub-human. This ideology then rationalized slavery, genocide, and many different types of discriminatory laws, policies, and actions. We can see this invention at work if we go back to the 1600s. During the earliest years of colonial Virginia, the line between servant and slave was ambiguous, and people were not identified by skin color but rather by nationality, language, or religion. During Bacon's Rebellion and similar rebellions, a coalition of Africans and Europeans threatened the wealth and status of elite wealthy landowners. Lawmakers created and codified a racial hierarchy in which Africans became chattel slaves for life and Europeans became compensated white indentured servants, thereby protecting the elite through a divide and conquer strategy. The creation of whiteness drew a line in the sand about who was allowed to be human and who wasn't. And when the European laborers accepted whiteness as their new identity, they gave up, generation after generation, their specific ethnic, religious, cultural, and linguistic European identity. That was a sacrifice they made in exchange for limited power. Anyone who was not white was seen as not even having a history or culture.
The fairly recent creation of Black History Month is an attempt to speak back against a system of oppression that has not allowed blacks their history or humanity for centuries. Today, when whites want to claim a "month" or a "hug," they are likely unaware of this history because it's not generally taught. However, we can work on that. While we need to continue to call out individual acts of racism, we also need to educate ourselves and other white people about this history so we can take action to address systemic racism; we can start with a narrative that directly confronts it. If you would like to know more about the ideas shared here, including tools for action, please check out my new book, "Dismantling the Racism Machine: A Manual and Toolbox," published by Routledge. Also, please consider joining the Hunterdon County Anti-Racism Coalition, as we meet monthly in Flemington (2nd Friday of each month at 6:30pm, 20 Fulper Road) to discuss and plan action against racism. The Coalition is available at hunterdonantiracism@gmail.com and has a Facebook group.
Karen Gaffney, PhD is Professor of English at Raritan Valley Community College (Karen.Gaffney@raritanval.edu), and the author of Dismantling the Racism Machine: A Manual and Toolbox. Her blog, Divided No Longer (available at https://dividednolonger.com/), has many resources about race and racism.
Help us fight the tide of racism that is sweeping through our district and country.
Outstanding statement! I, too, find that my family, neighbors and whites I know on SM have a VERY difficult time admitting to their unconscious privilege. Keep up the good work!
"...we also need to go much further than calling out individual acts of racism and confront the belief system buried in this sign and our own complicity in that narrative."


Davis (La Bohème, A Little Night Music) stars as Captain Georg von Trapp with Elena Shaddow (La Cage Aux Folles, Nine, Sweet Smell of Success) as Maria. They are joined by Chelsea Morgan Stock (The Little Mermaid, Sister Act) as Liesl, Gracie Beardsley as Marta, Greta Clark as Gretl, Maya Fortgang as Brigitta, Amanda Harris as Louisa, Hunter A. Kovacs as Kurt, Sean McManus as Friedrich, Edward Hibbert ("Frasier," Mrs. Warren's Profession) as Max Detweiler, Fedorov (Rent, The Fantasticks) as Rolf Gruber, Drama Desk nominee Donna English (Nice Work If You Can Get It, Ruthless!) as Elsa Schraeder, Suzanne Ishee (The Phantom of the Opera) as Mother Abbess, Robert DuSold (Mamma Mia!) as Franz and Joy Franz (Into the Woods) as Frau Schmidt.
Based on the true story of the von Trapp family, The Sound of Music is the final collaboration from composer Richard Rodgers and lyricist Oscar Hammerstein II and includes classic tunes such as "My Favorite Things," "Edelweiss" and "Climb Every Mountain." The musical features a book by Russel Crouse and Howard Lindsay.
Rounding out the cast are Ashley Kate Adams, Duke Anderson, Allison Blackwell (Sister Sophia), Jonathan Charette, Christine Cornell, Patrick David, Margaret Dietrich, Maggie Finnegan, Osborn Focht (Herr Zeller), Kera Halbersleben, Jenavene Hester, Dennis Holland (Baron Elberfeld), Norah Long, Robin Lounsbury, Anna McCarthy, Christopher Carl (Admiral von Schreiber), Jeannie Shubitz (Sister Margaretta), Adam Soniak, Chris Stevens, Mary Stout (Sister Berthe), Sally Ann Swarm and Nadine Zahr (Baroness Elberfeld). Other members of the creative team include music director Tom Helm, scenic designer James Fouchard, costume coordinator Amanda Seymour, lighting designer F. Mitchell Dana, sound designer Randy Hansen, hair and wig designer Leah Loukas and production stage manager Matthew DiCarlo.


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Jeffrey Alan "Jeff" Bucknum (* 12. Juli 1966 in Glendale, Kalifornien) ist ein ehemaliger US-amerikanischer Automobilrennfahrer.

Karriere

Jeff Buckum ist der Sohn des 1992 verstorbenen Ronnie Bucknum, der in den 1960er-Jahren der erste Honda Racing F1-Pilot war.

Jeff Bucknum versuchte in die Fußstapfen seines Vaters zu treten, als er ebenfalls eine Rennkarriere anstrebte, war dabei jedoch bis heute noch nicht sehr erfolgreich. 2005 startete er bei vier Rennen der Indy Racing League mit dem zehnten Rang beim Rennen am Infineon Raceway als bester Platzierung. Daneben fuhr der Amerikaner auch einige Rennen in der LMP-2-Klasse der American Le Mans Series

2005 debütierte er bei den 500 Meilen von Indianapolis, konnte sich jedoch nicht klassieren. 2006 war er schon in der zweiten Runde in einen Unfall verwickelt und beendete das Rennen schließlich auf dem 32. Platz. Bei sechs Rennen der Indy Racing League war er auch 2006 am Start, eine Platzierung im Spitzenfeld konnte er nicht verbuchen.

Statistik

Le-Mans-Ergebnisse

Sebring-Ergebnisse

Weblinks
 www.jeffbucknum.com – Website des Fahrers
 Jeff Bucknum bei 24-h-en-piste

IndyCar-Rennfahrer
Rennfahrer (Vereinigte Staaten)
US-Amerikaner
Geboren 1966
Mann
Rennfahrer der 24 Stunden von Le Mans
Rennfahrer der 12 Stunden von Sebring