text:
Senior Global Advocacy Adviser (Francophone), Conseiller principal en plaidoyer mondial (francophone), International, Senegal, Mali, Cameroon, Sightsavers
Sightsavers implements projects in over 30 countries in Africa and South Asia working to eliminate avoidable blindness and promote the rights of people with disabilities.
Salary: Local Terms and Conditions apply
To provide a link between the Sightsavers' global advocacy and the advocacy work of country offices in Francophone countries.
To advise on and support the effective delivery of Sightsavers' country level advocacy initiatives.
To lead Sightsavers' influencing work around implementation of the Sustainable Development Goals (SDGs) at the global, regional and national levels, ensuring that Sightsavers' work is rooted in the change it wants to see in social inclusion, inclusive education and eye health.
To manage, support and empower a Global Advocacy Officer within Francophone West Africa, who will work with you to support Sightsavers' country offices to influence public policy.
Principal Accountabilities:
Lead technical advocacy support for Sightsavers' country offices within Francophone West Africa, including line management of the Advocacy Officer (35%)
Provide effective line management to the Advocacy Officer in Francophone West Africa, building their capacity to support country offices with developing and delivering influencing objectives within and outside of donor funded programmes.
Lead on providing technical support to country offices for the development and implementation of strategic advocacy at the national level, both within and outside of donor funded programmes, to address systemic issues in eye health, universal health coverage (UHC), inclusive education and disability rights.
Support country offices to develop long-term strategic advocacy plans (5-10 years), which include objectives around eye health, inclusive education, social inclusion, and cross-cutting issues.
In collaboration with the relevant Global Advocacy Advisor, support country offices to engage at the national level on key global policy and regional advocacy priorities including UHC, CRPD, GDS, and global/regional meetings such as the 2021 Education Summit.
Support national level advocacy towards key multilateral and bilateral donors such as FCDO with the aim of influencing, holding them to account on and partnering with them on their priorities moving forward.
Provide technical support, training and capacity building to Francophone country offices for advocacy. This includes supporting country offices to identify change objectives, plan and implement advocacy activities, build relationships with decision makers and produce relevant resources.
Working with the MEL team, support country offices with monitoring and evaluation of advocacy objectives, including using the Levels of Influence, and promoting the Sightsavers' Advocacy Reporting App as a tool for monitoring outputs.
Coordinate Sightsavers' international SDG advocacy (40%)
Work with the Head of Advocacy to support the coordination of advocacy amongst partners, from the disability, health and wider development sectors, including through initiatives like Together 2030.
Coordinate Sightsavers' engagement with the High-level Political Forum.
Work with colleagues in the Communications Team and the Campaigns Team to ensure that everyone in Sightsavers understands the SDGs and our role in delivering them.
Build partnerships with national and regional actors (5%)
In collaboration with the other Global Advocacy Advisors, map stakeholders, and develop and build strategic partnerships and alliances with other key actors at the regional level, including regional intergovernmental bodies and the regional offices of multilaterals, to maximise advocacy opportunities and link global objectives to the regional level.
Support the delivery of Sightsavers' global policy campaign at the national level (10%)
Advise the campaigns team on tailoring the global policy campaign effectively to the national level to ensure real change is achieved and the campaign 'adds value' to existing national advocacy work.
Support country offices to deliver the campaign at the national level, ensuring the campaign aligns with existing ongoing national advocacy objectives and will build momentum towards these whilst also fitting with the global campaign.
Engage in internal PGA and organisational processes as appropriate (10%)
Ensure the development of an annual budget that covers the responsibilities of the role and adhere to regular PGA reporting processes.
Support national delivery of SIM card reporting and ensure timely reporting of SIM across the region.
Ensure that Sightsavers' safeguarding policy processes are adhered to. Responsibility for reporting safeguarding concerns as they arise.
Deputise for the Global Advocacy Manager and Head of Advocacy as required.
This is a highly varied and involved role and the above is not an exhaustive list of duties or required professional skills. Please see the Job Description for full details.
Knowledge (Education & Related Experience):
Relevant academic qualifications in a social science
Significant experience of working as an advocacy professional within INGOs and supporting national advocacy within a global advocacy strategy
Significant experience of representing NGOs at a high level on critical strategic issues, including building relationships with and influencing senior officials within national governments, donor agencies and regional bodies
Expertise in building staff capacities to develop and deliver effective advocacy strategies
Experience of developing and implementing systems to record and measure the impact of advocacy activities
Expertise in carrying out national level policy analysis and stakeholder mapping to develop effective advocacy strategies
Knowledge of current issues and best practice in development particularly in health, education, rights, or governance
Skills (Special Training or Competence):
Representing the organisation to external bodies at a high level
Ability to think strategically and translate this into effective action plans
Influencing organisational strategy and promoting change internally
Ability to develop and implement effective advocacy plans and M&E systems
Strong communication and relationship building skills with internal and external audiences
Working effectively as part of an international team
Please complete and submit all applications in English.
To apply for this exciting new opportunity, please complete an application via our recruitment portal. We are particularly interested in learning of your motivations for applying.
As an equal opportunity employer, we actively encourage applications from all sections of the community. Sightsavers is a Disability Confident Leader and qualified people living with a disability are particularly encouraged to apply.
Sightsavers is an employer that does not tolerate any form of harassment and has zero tolerance for sexual exploitation and abuse. All potential candidates will be subjected to rigorous background checks and controls.
Closing Date: 15 January, 2023
Postuler (Apply for the job) sur son site Internet: https://jobs.sightsavers.org/job/senior-global-advocacy-adviser-francophone/
Directeur/trice régional.e, Regional Director, Yaoundé, AUF – l'Agence Universitaire de la Francophonie
Coordinateur·trice Logistique – Cameroun, Logistics Coordinator – Cameroon, Yaoundé, Première Urgence Internationale


text:
Джордж Сідней Рейнор (, 13 січня 1907, Хойланд, Велика Британія — 24 листопада 1985, Бакстон, Велика Британія) — англійський футболіст, що грав на позиції півзахисника. По завершенні ігрової кар'єри — тренер.

Виступав, зокрема, за клуби «Шеффілд Юнайтед» та «Бері».

Дворазовий володар Кубка Швеції (як тренер). На чолі збірної Швеції — олімпійський чемпіон.

Ігрова кар'єра
Народився 13 січня 1907 року в місті Хойланд, що близько Барнслі, в сім'ї шахтаря. Вихованець юнацьких команд футбольних клубів «Елсекар Байбл Клас» і «Мексборо Атлетік».

У дорослому футболі дебютував 1929 року виступами за команду клубу «Вомбвелль», в якій провів один сезон.

Своєю грою за цю команду привернув увагу представників тренерського штабу клубу «Шеффілд Юнайтед», до складу якого приєднався 1930 року. Відіграв за команду з Шеффілда наступний сезон своєї ігрової кар'єри.

Згодом з 1932 по 1935 рік грав у складі команд клубів «Менсфілд Таун» та «Ротергем Юнайтед».

1935 року уклав контракт з клубом «Бері», у складі якого провів наступні три роки своєї кар'єри гравця.

Завершив професійну ігрову кар'єру у клубі «Олдершот», за команду якого виступав протягом 1938—1939 років.

Кар'єра тренера

Розпочав тренерську кар'єру, повернувшись до футболу після невеликої перерви, 1943 року, очоливши тренерський штаб збірної Іраку.

1946 року став головним тренером збірної Швеції, яку тренував вісім років.

Згодом протягом 1948–1952 років очолював тренерський штаб клубу АІК.

1954 року прийняв пропозицію попрацювати у клубі «Лаціо». Залишив «біло-блакитних» 1955 року.

Протягом одного року, починаючи з 1956, був головним тренером команди «Ковентрі Сіті».

1956 року був запрошений керівництвом збірної Швеції знов очолити команду. Він зміг переконати Шведський футбольний союз в необхідності залучення гравців-професіоналів, які виступають за іноземні клуби. І на чемпіонат світу 1958 поїхали найсильніші гравці, включаючи Лідгольма, Хамріна, Сельмоссона і Скоглунда, що грали в Італії, а також Брор Мельберга з чемпіонату Франції. З цими футболістами Швеція, по ходу турніру, змогла обіграти чемпіонів і віце-чемпіонів минулого турніру, німців і угорців, а також олімпійських чемпіонів 1956, збірну СРСР. Лише у фіналі Швеція програла Бразилії з рахунком 2:5. За це досягнення Рейнер став кавалером ордена Вази.

У 1960 році очолював тренерський штаб команди «Юргорден».

1961 року строком на один рік втретє став головним тренером збірної Швеції.

Протягом тренерської кар'єри також очолював команди клубів ГАІС, «Отвідабергс ФФ» та «Сеньєсс Таун», а також входив до тренерських штабів клубів «Олдершот» та «Ювентус».

Останнім місцем тренерської роботи був клуб «Донкастер Роверз», головним тренером команди якого Джордж Рейнор був з 1967 по 1968 рік.

В кінці життя Райнер отримав інвалідність через ускладнений ревматизм. Помер 24 листопада 1985 року на 79-му році життя в місті Бакстон, графство Дербішир.

Титули і досягнення

Як тренера
  Володар Кубка Швеції (2):
АІК: 1949, 1950
  Олімпійський чемпіон: 1948
  Бронзовий олімпійський призер: 1952
 Віце-чемпіон світу: 1958
 Бронзовий призер чемпіонату світу: 1950

Нагороди
  Кавалер ордена Вази: 1958

Примітки

Посилання

англійські футболісти
англійські футбольні тренери
Тренери чемпіонату світу з футболу 1950
Тренери чемпіонату світу з футболу 1958
Футболісти «Шеффілд Юнайтед»
Футболісти «Менсфілд Тауна»
Футболісти «Ротергем Юнайтед»
Футболісти «Бері»
Футболісти «Олдершота»
Тренери збірної Іраку з футболу
Тренери ФК «Олдершот»
Тренери збірної Швеції з футболу
Тренери ФК ГАІС
Тренери ФК АІК
Тренери ФК «Отвідаберг»
Тренери ФК «Ювентус»
Тренери ФК «Ковентрі Сіті»
Тренери ФК «Юргорден»
Тренери ФК «Донкастер Роверз»

redpajama_set_name: RedPajamaWikipedia


text:
Several privateers during the Age of Sail were named for Napoleon Bonaparte:

 Buonoparte was a 16-gun privateer, commissioned in Brest in 1796 with 137 to 167 men and 16 guns.  captured her on 24 October 1796 South of Ireland. Buonoparte was the former packet King George, probably the one captured in 1794.
 Bonaparte was a privateer commissioned in Dunkirk in December 1796 under Jean Meulenaer, with 24 men and 10 to 15 guns. After a first cruise between December 1796 and January 1797, she sortied again in February with a 110-man crew. HMS Espion and Martin captured her on 14 February 1797.
 Buonaparte was a 32-tonne privateer cutter commissioned in Saint-Malo in 1797 under F. Roussel, with 32 men and 3 guns.  captured her in the Caribbean circa June 1797.
 Bonaparte was a lugger requisitioned at Anconna in March 1797 and commissioned in the French Navy as an aviso with six 6-pounders. She was last mentioned while at Bonifacio in April 1799. She might have become the aviso Redoutable, commissioned at Bastia on 8 May 1800 that the British captured near Pantalleria in June 1800.
 Bonaparte was a privateer commissioned in Boulogne in May 1799. She did two cruises, from May to July 1799, and from October 1799 to March 1800, under Jean-Baptist Pollet, with 46 men.
 Bonaparte was a "privateer frigate" commissioned in October 1797 under a Captain Lamotte, with 250 men and 32 guns.
 Bonaparte was an 8-gun schooner commissioned as a privateer and captured in 1799 in the Atlantic by the .
 Bonaparte was a 75-ton, 14-gun privateer brig commissioned in Bayonne in June 1797 under Louis Boulager. She did a cruise from June 1797 to March 1798 with 10 to 13 officers and 62 to 67 men.
 Bonaparte was a privateer trincadour commissioned in Bayonne in 1798 or 1799 under a Captain Lazue or Lazuc. She cruised in February 1799 with  a 15-man crew.
 Bonaparte was a privateer from an unknown home port, operating in the Mediterranean in early 1798, with 40 men and 2 guns.  captured her in February 1798.
 Bonaparte was a privateer from an unknown home port, operating off Genoa in April 1799.
 Bonaparte was a privateer commissioned in Guadeloupe in January 1798.  captured her off Martinique in 1799.
 Bonaparte was a privateer commissioned in Guadeloupe in September or October 1799 under Ensign Pierre Martin, with 30 men and twelve 4-pounder guns. She engaged British forces off Porto Rico on 14 October 1799. Two days later,  captured her.
 Bonaparte was a privateer from an unknown homeport, operating in the Caribbean in early 1799, with 50 men and 6 guns. A British squadron under Admiral Parker captured her in March 1799.
 Bonaparte was a 58-ton privateer built in Honfleur by Nicolas Loquet and commissioned in Rouen in 1798 under Captain Degaule. From 4 April to 23 June 1798, she was requisitioned by the French Navy, and manned by a 3-officer and 25-man crew. She might be the 72-man, 8-gun Bonaparte that  and  captured in November 1798.
 Invincible General Bonaparte was a French privateer of 20 guns and 170 men that the frigate  captured on 9 December 1798 and that the Royal Navy took into service as HMS Brazen.
  (or Invincible Bonaparte, or later Invincible), which the  British Royal Navy captured three times and American privateers captured twice.
 was the French privateer Bonaparte that  captured in November 1804. Pert was wrecked in October 1807 off the coast of what is now Venezuela.
 was a schooner purchased in 1805, whose crew mutinied in 1806 and turned her over to the French who sent her out as the privateer Napoleon. Within four days of the mutiny  had recaptured her; she was taken back into service under her original name and broken up in 1808.
Napoléon, ex-Bonaparte, was a three-masted privateer from Saint-Malo built in 1803 and 1804, and commissioned at Saint-Servan in January 1805. Her draft was 3.35 metre empty, and 4.87 metre when fully loaded; she was of 400 tons (French; "of load"). She was armed with 28 guns (four 8-pounders, six 6-pounders, sixteen 32-pounder carronades, and two 36-pounder obusiers. she sailed to Isle de France (Mauritius)  under Malo-Jean Le Nouvel with 147 to 180 men. She then made two more cruises from Ile de France with 180 to 250 men, and 32 guns. She ran aground on 23 November 1806 at Hood Bay while under fire from  and another British frigate; Napoléons crew managed to escape.
Grand Napoléon was a settee, pierced for 10 guns but only four mounted, with a crew of 38 men, that  captured on 2 May 1808.
 Grand Napoléon was a privateer commissioned in Boulogne in March 1806. She cruised under Captain Huret from January to February 1808, and later under a captain Fourmentin.
 Grand Napoléon was from Boulogne, purchased for 25,000 francs from a Mr. Foube from Calais and commissioned in September 1808. Under Pierre-Marie Wasselin she cruised with 68 men from September 1808 to February 1809, and under Antoine Huret, with 55 men, she cruised from June 1809 to November 1809.  captured her on 17 November 1809; she was armed with 18 guns and had a crew of 75 men.
Grand Napoléon, of Nantes, and about 240 tons (bm), was three months old when  captured her on 19 April 1810. Grand Napoleon was armed with twelve 18-pounder carronades and four long guns. She had a crew of 124 men.
 was the French privateer Bonaparte (or Napoleon), captured in 1809 (or 1808). She served the Royal Navy in the Leeward Islands until broken up in 1815.
Napoleon (alias Diaboloten), of 10 guns, was a vessel the Royal Navy captured at Malaga on 29 May 1812.
Grand Napoleon, Howard, master, was a new American letter of marque schooner of 305 tons (bm), four guns, and 32 men, that  captured on 3 April 1813.

See also

 French ship Napoleon
 Napoleon (ship)

Citations

References

Ship names
Privateer ships of France


The ceremony was held in a beautiful white chapel that was the perfect backdrop for simple flower arrangements, like the urns filled with Lisianthus and Stock.
We bring a lot of furniture and decor to our weddings and setting up can be quite time consuming. For this wedding, the ceremony started at 4:00 and we could not start setting up the reception until 4:00 (there was a event prior to ours). We knew the guests would be arriving at the reception venue for cocktails as soon as the wedding was over and for obvious reasons, we could not remove the flowers from the wedding chapel until all the guests were gone. It didn't seem possible to use the same flowers for both venues, at least not at the country club entrance and staircase that the guests would see when they first arrived.
And so when we were planning the flower arrangements we told the client we would need to purchase enough flowers for each venue. It was not logistically possible to get the flowers from the chapel to the reception before the guests arrived. I gave the bride and her mother a "ballpark" flower budget based on the last three weddings we styled.
But when we got to the flower mart, we quickly discovered that SUMMER FLOWER PRICES ARE NOT THE SAME AS WINTER PRICES. Summer flower prices are lower than the rest of the year, something I did not know. Hydrangeas which just a month ago were $1 a stem are now $2 a stem. Twice the price. And so with my flower budget cut in half I had to re-group and make some adjustments in both the kind of flowers I purchased and also how and where we would use them.
Instead of using bunches of Hydrangea like I had planned, the large urns for the ceremony were filled with bunches of Lisianthus and Stock which were quite a bit less expensive. Stock is a very inexpensive flower that comes in several beautiful colors and when fresh, they give off a lovely clove-like scent. But their "shelf" life is very short and you have to change the water often as it can get quite smelly so they are not always ideal to use for a wedding. Luckily these were as fresh as could be and worked perfectly.
Just inside the entry doors was a small foyer and behind the doors a charming chapel with beautiful wooden pews. A large ceramic urn with white Lisianthus greeted the guests.
We placed white orchids on both sides of the aisle. The orchids came with floral water tubes on each stem which we left on until an hour before the ceremony to keep the flowers as fresh as possible. We would be using these same flowers later at the reception to line the winding staircase leading to the ballroom.
Below you see the same urn from the chapel foyer on the reception check-in table.
How did we do it? We had three separate crew members waiting at the chapel for the wedding to end. One picked up the aisle flowers as soon as the guests walked out and rushed them back to us waiting at the country club. We quickly tied them on the staircase. Another crew member was in charge of just the flowers at the entrance of the church and brought those to us a soon as was possible. Those were placed at the country club entrance minutes before the guests arrived. The final group picked up what was left after the photographer finished taking the photos of the wedding party up in the front of the chapel and brought the last two arrangements to us literally minutes before our deadline. We placed them, took a few photographs and slipped out the back. We left at 6:05.
Come back later in the week to see the full wedding post. Happy Monday everyone!
Sherri I love how organized you are! Everything looks so beautiful and it's very interesting to hear the details of how you pulled it off. Great job! Looking forward to hearing more about it.
Everything looks so nice! I know they were happy!
Once again you created another beautiful wedding! The bride and groom must have been over the moon!


text:
package org.waveprotocol.wave.model.adt;

import org.waveprotocol.wave.model.wave.SourcesEvents;

/**
 * An extension of the element list that broadcasts events whenever the state of
 * the list changes.
 *
 */
public interface ObservableElementList<T, I> extends ElementList<T, I>,
    SourcesEvents<ObservableElementList.Listener<T>> {
  /**
   * Defines the methods of the listener to element list events.
   */
  public interface Listener<T> {
    /**
     * @param entry A new value that was added to this list.
     */
    void onValueAdded(T entry);

    /**
     * @param entry An existing value that was removed from the list.
     */
    void onValueRemoved(T entry);
  }
}

redpajama_set_name: RedPajamaGithub


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I brought out my slow cooker again – we were going to busy and dinner was either going to be late and out or I could make it beforehand. OK so I also wanted to try a new recipe I found. It all works right?
I actually used my slow cooker for the sweet and sour chicken that I will confess was ridiculously easy to just throw everything in the crockpot before I went to work and put it on low and go. But when I got home I used the rice cooker so dinner was literally all set when we were done with our meeting. So easy and very tasty plus it was a huge time saver and way cheaper than going out.
I don't always plan ahead; or at least not as much as I wish I did but having a nicely stocked pantry and freezer plus having plenty of homemade chicken stock on hand I can whip up some of the recipes I come across. This one I did have to pick up a red pepper and a pineapple; well I didn't need an actual pineapple but I have another recipe in mind for the rest of the pineapple.
My chicken stock was still frozen – it will melt!
Take all the above and put it in your slow cooker and turn it on low for about 7-8 hours.
Remove the chicken and set it aside.
Turn it on high and slowly add the pineapple/starch mixture. And the other ¼ cup of ketchup. Cook this uncovered until the sauce is thick. Shred the chicken and add it back into the pot to re-heat.


text:
14 Iloilo schools pilot senior high classes for ALS
By Perla Lena October 21, 2022, 6:28 pm
TRAINING. The Department of Education Division of Iloilo holds a workshop cum orientation on the Alternative Learning System (ALS) senior high school (SHS) delivery for the implementers this October. Michael O. Tamallana, Senior High School Coordinator of the Schools Division of Iloilo, said Friday (Oct. 21, 2022) that currently 676 learners are enrolled in SHS in the 14 pilot areas in the province. (Photo courtesy of Michael O. Tamallana FB page)
ILOILO CITY – Fourteen secondary schools in the province of Iloilo are offering the pilot run of the senior high school (SHS) classes for the Alternative Learning System (ALS).
Michael O. Tamallana, Assistant School Principal II of the Pavia National High School and at the same time Senior High School Coordinator of the Schools Division of Iloilo, said on Friday that currently 676 learners are enrolled in SHS in the 14 pilot areas in the province.
Iloilo province has the most number of schools that showed a willingness to implement the program out of the 48 schools that were piloted in Western Visayas starting this school year.
"They really took the challenge to implement this program," he said.
The ALS SHS is now available at the Alimodian National Comprehensive High School (NCHS), Janiuay NCHS, Pototan NCHS, Anilao National High Schools (NHS), Dingle NHS, Estancia NHS, Guimbal NHS, Igbaras NHS, Oton NHS, Pavia NHS, Sara NHS, Tubungan NHS, Leonora S. Salapantan NHS in San Miguel, and at the Iloilo National High School.
All strands or tracks that are offered in the regular program are also available in the ALS.
"For now since we are encouraged by the central office and the regional office to implement the pilot implementation of this program, so we are using the MELCs (most essential learning competencies) of the formal senior high school," Tamallana said in an interview.
The classes are on a blended modality or a combination of face-to-face and modular.
Tamallana said junior high school ALS completers are encouraged to pursue senior high school since they are only holding a certificate of completion and not the diploma as proof that they are high school graduates.
"We want them to have the diploma because the basic requirement to have a job or become permanent in their jobs is their diploma as high school graduate," he added.
Meantime, he said training is ongoing for the implementers of the Contextualized MELCs-Based ALS SHS curriculum and they are still waiting for the go signal from the central office and the Bureau of Alternative Education as to when to roll out the curriculum guide intended for the senior high school.
Republic Act 11510 or the Alternative Learning System Act mandates the opening of alternative education to out-of-school children in special cases, out-of-school youth, and out-of-school adults to include among others Indigenous Peoples, learning with disabilities, teenage mothers, socio-economically disadvantaged learners, children-in-conflict with the law, persons deprived of liberty, rebel returnees, learners in an emergency situation and other marginalized sectors unable to participate in formal schooling and have not completed basic education. (PNA)
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redpajama_set_name: RedPajamaCommonCrawl


text:
I linfomi non Hodgkin (LNH) sono neoplasie maligne del tessuto linfatico, con localizzazione primitiva nei linfonodi e che più raramente possono comparire in sede extra-nodale (cute, ghiandole esocrine, gonadi, apparato gastro-enterico, sistema nervoso centrale).

Tipologie
Esistono più di venti tipi di linfomi non-Hodgkin. Tra questi, il linfoma follicolare, il linfoma diffuso a grandi cellule B, e il linfoma primitivo della cute.

La classificazione dei linfomi è molto complicata sul piano clinico, una distinzione si può fare solo sul piano istologico, che resta anche l'unica diagnosi di certezza. Data la somiglianza nell'evoluzione della patologia con le leucemie, che rappresentano il corrispettivo ematologico dei linfomi in ambito oncologico, spesso in fase avanzata diventa difficile (se non impossibile) distinguere sottotipi di linfomi da analoghi sottotipi leucemici.

I linfomi sono spesso dovuti a linfociti di tipo B e T che proliferano in maniera incontrollata in linfonodi e poi in organi linfatici, e alcune varianti, come quelli a piccole cellule o linfoblastici possono diffondersi e assumere carattere sistemico. L'unica generica classificazione che si può fare è pensare a ogni stadio di maturazione e differenziazione del linfocita come al corrispettivo tipo istologico di linfoma. La maggior parte dei linfomi è dato da linfociti B, ma molti linfomi a cellule T sono legati ad anomalie cromosomiche, quindi su base genetica, e sono rilevabili soprattutto in specifiche etnie (oriente) e spesso associate, in paesi in via di sviluppo, a coinfezioni (per esempio con virus del tipo HIV, dove alcuni linfomi, come il Linfoma di Burkitt, assumono carattere endemico).

Il linfoma mantellare è un tipo di linfoma caratterizzato da un'iperproduzione di linfociti piccoli e clivati e pertanto va effettuata la diagnosi differenziale con la leucemia linfocitica cronica (che presenta però centri di proliferazione) e il linfoma follicolare (che presenta però anche centroblasti) dato che hanno caratteristiche cellulari simili. La zona della lesione è nella zona mantellare del linfonodo ovvero la prima tappa che i linfociti B raggiungono dopo il midollo osseo. In questo tipo di linfoma un'anomalia cromosomica porta a un'iperespressione di ciclina D1, una proteina con un importante ruolo nel ciclo cellulare. La prognosi è solitamente infausta nel giro di 3 anni e pertanto la terapia solamente palliativa per allungare questo periodo.

Il linfoma follicolare è caratterizzato da molte cellule di piccole dimensioni (centrociti) e da poche cellule di grandi dimensioni (centroblasti). È presente un'anomalia cromosomica che porta a un'iperespressione del BCL2 il quale agisce come antiapoptotico. Questo linfoma è il linfoma non Hodgkin generalizzato e non dolente più frequente. Il decorso resta indolente.

Il linfoma a grandi cellule B (DLBCL) è un linfoma localizzato e dolente, il più frequente di questo tipo. È caratterizzato da un'anomalia cromosomica che porta a un'iperespressione del BCL6, essenziale per stimolare la proliferazione e al contempo inibire la differenziazione. Può coinvolgere sedi linfonodali come l'anello di Waldeyer o extranodali come l'apparato cutaneo, gastrointestinale, nervoso centrale e osseo seppur raro e tardivo. È un tipo di linfoma molto aggressivo che può evolvere dal linfoma follicolare o dalla leucemia linfatica cronica. Tuttavia la chemioterapia è risolutiva nel 60% dei casi.

Il linfoma di Burkitt è un linfoma che colpisce prevalentemente i bambini. È caratterizzato da un'iperespressione di c-myc. Viene classificato in 3 tipi: sporadico, endemico, associato a HIV. Il linfoma di Burkitt endemico è sempre causato da un'infezione di EBV e coinvolge principalmente la mandibola e l'apparato urogenitale. Il linfoma di Burkitt sporadico è nel 20% dei casi associati a un'infezione di EBV e coinvolge l'ileo e il peritoneo. Il linfoma di Burkitt associato a HIV presenta una coinfezione da EBV nel 25% dei casi. Anche in questo caso il linfoma è aggressivo ma la cura risolutiva soprattutto se colpiti bambini e giovani adulti.

I linfomi della zona marginale sono localizzati in una zona linfonodale dove i linfociti transitano dopo aver lasciato il centro follicolare. Questi linfomi possono essere localizzati sia in sedi linfonodale sia splenica sia extranodale. In quest'ultimo caso assumono il nome di MALTomi e sono localizzati in tessuti colpiti da flogosi autoimmune (per esempio la tiroide nella tiroidite di Hashimoto o le ghiandole salivari nella Sindrome di Sjögren) o infettiva; pertanto incominciano come iperplasia reattiva e terminano come iperplasia neoplastica. Possono regredire eliminando la causa flogistica.

Localizzazione
Potendo comparire teoricamente in ogni linfonodo dell'organismo ed essendo i linfonodi disseminati ovunque, la malattia e la sintomatologia può sorgere ovunque. La diagnosi si effettua su esami di laboratorio, dove oltre l'esame del sangue e l'elettroforesi delle proteine, in cui si rivela un picco di gammaglobuline, per l'aumento degli anticorpi prodotti dal clone linfocitario B iperproliferante (nei linfomi B), resta fondamentale l'esame istologico. La diagnosi può essere raggiunta con certezza, e il tipo istologico identificato, anche se con non poche difficoltà in una buona percentuale dei casi sulla base del semplice esame microscopico, ma nei casi più difficili attraverso la determinazione del profilo immunofenotipico. La prognosi e l'evoluzione della malattia dipende fortemente dalla variante tipica e dal singolo caso clinico, oltre che dallo stadio di evoluzione della malattia.

Linfoma della milza
Secondo la più recente classificazione dei linfomi (la WHO), il linfoma della milza appartiene ai linfomi non Hodgkin a linfociti B indolenti. Il linfoma della milza origina dalla zona marginale; è una neoplasia la cui incidenza reale è in atto sottostimata. Non ci sono marcatori di malattia distintivi, i criteri diagnostici sono tuttora in via di definizione, e pertanto spesso questa patologia viene mal diagnosticata (spesso classificata come processo linfoproliferativo cronico atipico). È una patologia tipica del paziente anziano (età mediana di incidenza 70 anni) e viene diagnosticata in seguito al riscontro di linfocitosi, anemia, piastrinopenia e splenomegalia.

Il quadro clinico può presentarsi anche in maniera più sfumata (ad esempio, solo linfocitosi) e pertanto la diagnosi richiede l'esame emocromocitometrico, l'esame morfologico dello striscio di sangue periferico, l'analisi citofluorimetrica dei linfociti da sangue periferico, e lo studio del midollo osseo (pattern di infiltrazione intrasinusoidale, che è un hallmark della patologia).

Il decorso clinico è in genere indolente, tuttavia circa un terzo dei pazienti ha un andamento clinico più aggressivo, ed è proprio su questo gruppo di pazienti che si concentrano gli sforzi dei clinici per approntare nuovi protocolli terapeutici.

Terapia
L'obiettivo della terapia può essere l'eradicazione o il contenimento della malattia. Nei LNH ad alto grado di aggressività, l'obiettivo è sicuramente l'eradicazione della malattia, poiché è possibile guarire in maniera definitiva il 50-60% dei pazienti. Al contrario, nelle forme di linfoma a basso grado di aggressività, l'eradicazione della malattia è un obiettivo più difficile da ottenere (circa il 30-40% dei casi). Il fine ultimo, in questo caso, diventa quindi il contenimento della malattia che, nel corso del tempo, tende a ricadere, pur consentendo una vita di relazione pressoché normale e una lunga sopravvivenza.

Se il paziente è nelle fasi iniziali della neoplasia ed è asintomatico, come può accadere nei linfomi a lenta progressione, si ricorre al cosiddetto "watch and wait", ovvero un periodo di osservazione in cui si monitora nel tempo l'andamento della malattia. Quando questa diventa sintomatica o incomincia a progredire rapidamente, si rende necessario seguire un trattamento. L'approccio terapeutico al linfoma non Hodgkin si articola in:
 Radioterapia, utilizzata nei casi di malattia localizzata o in stadio iniziale, oppure dopo la chemioterapia per consolidare il trattamento.
 Immuno-chemioterapia, l'approccio terapeutico maggiormente impiegato per contrastare la crescita tumorale. Nell'ultimo decennio un importante apporto alle terapie è stato dato dall'impiego degli anticorpi monoclonali anti-CD20. Gli anticorpi anti-CD20 eliminano in maniera selettiva le cellule che esprimono sulla loro superficie la molecola CD20, una proteina trans-membrana presente sulla superficie cellulare sia dei linfociti tumorali, sia di quelli sani. In questo modo, vengono risparmiate le altre cellule sane ad attiva proliferazione, che vengono invece danneggiate quando si usa la chemioterapia. Il vantaggio dato dall'utilizzo dell'anticorpo monoclonale anti-CD20 è stato dimostrato da uno studio del gruppo francese GELA, in cui è emerso che l'aggiunta dell'anticorpo monoclonale incrementa notevolmente la risposta clinica e la sopravvivenza dei pazienti, rispetto alla sola chemioterapia. Uno degli schemi terapeutici più utilizzati per il trattamento di molti tipi di linfoma non Hodgkin (follicolare, mantellare, diffuso a grandi cellule) è l'R-CHOP (rituximab - ciclofosfamide, adriamicina, vincristina e prednisone). Recenti evidenze, tuttavia, hanno dimostrato che, nel linfoma follicolare e mantellare, il trattamento con bendamustina associato a rituximab aumenta la percentuale di risposta del paziente e la sopravvivenza libera da progressione di malattia, con una minore incidenza di effetti collaterali rispetto al regime R-CHOP.
 Trapianto autologo o allogenico di cellule staminali: viene utilizzato in pazienti con caratteristiche prognosticamente sfavorevoli, nei pazienti che ricadono in tempi brevi dall'ottenimento della remissione completa e, soprattutto, in quei pazienti che mostrano una scarsa risposta alla sola chemioterapia.

Note

Bibliografia

Voci correlate
 Linfoma
 Antracicline

Collegamenti esterni

 Linfoma non Hodgkin. Clinica Ematologica – Università di Pavia
 AIL, su ail.it

Non Hodgkin


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So, is green the color of rebirth, or just a color of joy? I've never quite been able to figure that out, although the greenness of new plants in springtime fills me with joy at the rebirth of the season. The smell of new ferns coming out of the dirt can be wonderful — a sort of green scent.
Since it's also a color of Winter (evergreens, Christmas celebrations), it's kind of hard for me to pick. I just know that I have lots of green around the house, besides potted plants: 2 purses, 1 cell phone, costume jewelry, blouses, yarn, skirts, hats. It's one of my favorites, as well as a color that fills the environment I live in — from spring through autumn at least. So, I limited myself here to a few books, a favorite cup from Budapest, and a lovely bit of sock reinforcement yarn. I've done more studies of green here.


American Airlines has launched a new style of award tickets called Economy Web Specials. Please consult the individual credit card agreements and reward rules for specific earn rates.
American Airlines employees who are looking for the online web portal to access their company email can utilize the Microsoft Outlook Web app that is located at webmail.aa.com.
Worth, TX, they have an extensive international and domestic network with 953 aircraft making.
SeatGuru was created to help travelers choose the best seats and in-flight amenities.A single ticket may have up to eight flight segments, so you could have multiple boarding passes for each.American Airlines is one of the largest airlines in the world, with flights to over 250 destinations across the United States and around the globe.
Nowadays, AA Airlines is responsible for more than 3,500 departures daily.
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I had a bad experience as I felt they were terribly outdated, so I complained with their customer service, who, ironically, gave me a paper voucher that.More patriotic than bald eagles and bacon, American Airlines has been leading the way in aviation since the 1930s.As an oneworld partner, passengers can enjoy travel on one ticket to over 800 destinations.Savings may vary based on availability, advance purchase, minimum stay, travel dates, and blackout dates.
We have tried pinging American Airlines website using our server and the website returned the above results. If aa.com is down for us too there is nothing you can do except waiting.CLT oversees more than 700 departures and landings each day, and is served by seven domestic carriers and three foreign flag carriers.
Charlotte Douglas International Airport is the sixth busiest airport in the world offering more than 160 nonstop destinations around the globe.To receive your legal notices electronically, your computer must be capable of printing or storing email, web pages and documents in PDF format and your browser must meet minimum system requirements.Book your flight with American Airlines and save big on your trip.Eligible American Airlines purchases are items billed by American Airlines as merchant of record booked through American Airlines channels (AA.com, American Airlines reservations, and American Airlines airport and city ticket counters).


Architect/writer specializing in landscape architecture. Member of the Garden Communicators International (USA), Association des Journalistes du Jardin et de l'Horticulture (FRANCE) and National Order of Italian Journalists (ITALY). Actively working as a freelance journalist across various trade and consumer magazines, plus a selection of european titles. Jury's member in several international Garden Festival and Trade Fair. Specialist subjects: Landscaping/Landscape Design, Contemporary Garden Design, Flower Show & Trade Events.


Joyce Smith`s son John is pronounced dead after falling through an icy lake in Missouri one winter. She keeps praying for a miracle, praying loudly to God to save his life, even though the 14-year-old boy has been lying lifeless on the hospital bed for more than an hour. Miraculously, her son`s heart starts to beat once again.


CHARLOTTE – Pro-life activist Flip Benham remains a free man after a judge ruled to not revoke his bond on Friday.
In 2010, Benham was charged and later convicted of stalking a Charlotte-area doctor. He's currently awaiting the results of his appeals hearing and is out on post-conviction release. On Friday, he arrived at the Mecklenburg County Courthouse ready to be locked up.
"That's fine with me. The venue of the ministry just changes and I'm in jail, but it's the same ministry and I'm just thankful for that," said Benham.


"Seeds" was taken in Stockholm, Sweden's Djurgården.
Darin Wahl is a budding sustainability scientist, a teacher, and a wandering photo-storyteller. His work is an exploration of the human-environment interface and the struggles of these intertwined worlds to live and thrive. You can find more about him on his website.


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Jonathan T. D. Neil is the Co-Founder of Inversion Art, an investment accelerator program and artist services agency designed to provide artists with the knowledge, connections, and operational support they need to focus on creating their most ambitious work.
Jonathan is also Associate Provost for Academic Affairs and Strategic Initiatives, as well as Associate Professor of Art Business and Arts Management, at Claremont Graduate University (CGU). Prior to assuming his role in the Provost's office, he was the Founding Director of the Center for Business and Management of the Arts (CBMArts) at CGU, and of Sotheby's Institute of Art – Los Angeles, which ran at CGU from 2013 until 2019.
Since 2010 Jonathan has served in various editorial roles, most recently as Contributing Editor, for ArtReview magazine. From 2011-2016 he was editor of the Held Essays on Visual Art for The Brooklyn Rail, and from 2008 until 2014 he was Executive Editor at The Drawing Center in New York City.
In 2005 he co-founded Boyd Level LLC, a private curatorial firm and consultancy that specializes in contemporary art.
Jonathan has a PhD in 20th-Century Art History from Columbia University and a B.Arch from Cornell University. He has taught courses on modern and contemporary art and architectural history, the international art market, critical writing, critical theory, and the history of photography at Columbia University, Parsons The New School for Design, and Sotheby's Institute of Art in New York. He is a member of the New York Chapter of the International Association of Art Critics (AICA).
On Twitter and Instagram @jtdneil.
For a complete CV click here.
Miscellaneous media mentions:
Named to The Observer's "Arts Power 50", 2019
"The Brand's In Basel's Orbit," The New York Times, March 7, 2015
https://www.nytimes.com/2015/03/08/business/the-brands-in-art-basels-orbit.html?auth=login-email&login=email
An acrylic-on-wood panel from "Ryan McGinness Works," reviewed by Stephen Heller in The New York Times, June 4, 2010.


Henk Blom finished his Chemistry study in 1985 and received his PhD in 1988 at the Radboud University Nijmegen. After his post-doc period at the Human Genetics Branch, NIH, USA (William Gahl), he became post-doc in 1990 and later in 1992 staff member of the Clinical Genetics Center Nijmegen at Laboratory of Pediatrics and Neurology, University Hospital Nijmegen, the Netherlands.
Among inborn errors of metabolism his group described the molecular basis of severe hyperhomocysteinemia. They also explored cystinosis and defects in the methionine methylation pathway, including methionine adenosyltransferase deficiency. They discovered two new genetic defects: one in folate metabolism: dihydrofolate reductase deficiency and one defect in methylation: adenosine kinase deficiency. Prof Henk Blom is coordinator of EHOD, an international consortium on homocystinurias and methylation disorders. In 2017 the consortium consisted of almost 100 partners. Main achievements are the setup of the E-HOD registry (www.EHOD.registry.com) and website (www.EHOD.com) with information for expert as well as patients and their families. In addition four guideline manuscripts have been published, teaching courses and Patient – Expert Meetings organized.


Well-positioned real estate can be a reliable cash-generating asset that ensures predictability over a period of time. Michael Magiera, portfolio manager of the Manning & Napier Real Estate Series Fund, focuses on understanding the long-term, free cash-flow generating capabilities of investments, their quality and valuations. The fund assesses the entire spectrum of real estate to find the right opportunities for earning risk-adjusted returns.
Q: How has the fund evolved over time?
A: The fund opened in late 2009, when we were just coming out of the global financial crisis, which had significant impacts in the real estate arena. As an investment management firm, we have been around for over 40 years and we had evaluated and invested in real estate, but we did not have a dedicated real estate product. In 2008, when we saw the developments in the real estate markets, we began to prepare for what we thought was a good buying opportunity. We didn't view it as a trade but as a good time to start.
Our approach towards real estate is based on the fundamental investment philosophies of our firm. For example, when we consider purchasing an investment, we look at the cash flow that the investment generates today and going forward. We also examine what factors may affect that cash flow stream. We are looking not only at the sustainability of cash flow, but at the potential for growing it. The important factors include the competitive alternatives, whether there is new supply coming, whether demand is greater than supply, and how that affects the pricing power.
Real estate is a highly cyclical industry, so we need to be aware of our position not only in the economic cycle, but also in the various property cycles. In 2009, we were in the midst of a large residential housing crisis, which certainly had an impact on the way we initially positioned the fund. I believe that we are experienced and adept in managing through cycles.
Q: What are the core beliefs behind your investment philosophy?
A: We are cash-flow driven, price sensitive and focused on quality. Our investment philosophy is driven by a cash-flow framework, where we need to understand the size and the growth potential of the expected cash flow stream. Then we can decide what we are willing to pay for it today.
For us, real estate is all about the cash flow and, more specifically, the cash flow that the owner gets to keep. That means not only the earnings but looking at required reinvestment that reduces the cash flow available to investors. Well-positioned real estate represents a unique asset with a contract, which guarantees revenues for a period of time. So, there's some degree of expected certainty in the cash flow. Hence, we try to understand the long-term, free cash-flow generating capabilities of an asset.
We evaluate the entire spectrum of real estate, including residential, retail and office real estate. Within the residential segment, there are apartments, single-family rentals, manufactured housing and some would include student housing. There are many different categories and subcategories. We break them down and we try to understand where the free cash flows are likely to be sustained and growing.
I think that it is essential to be fundamentally driven and to keep the focus on the business and the cash flow drivers. The qualitative aspect makes sure that the investments are in areas that we view are the strongest. We look at fundamental drivers and we make active investments only if they fit our strategies and match our pricing discipline. We look for opportunities to overemphasize these sectors and property types in our portfolio. Conversely, we avoid or de-emphasize the areas, where we believe that the valuation is excessive and the opportunity for decent returns is poor.
For us, it is important not only what we own, but also what we pay for it. We look at the universe of attractive investments and compare them with their current valuations to find opportunities for investment. So, we are valuation driven and we need to know each investment qualitatively and quantitatively. The idea is buying the REITs when they present an opportunity to earn risk-adjusted returns.
Q: How does your investment philosophy translate into an investment process?
A: We have a team of analysts dedicated to the fund and a group-based decision making process. Each of us covers different sectors in the market, but we have the broader portfolio responsibility as well.
We build the portfolio one security at a time, although certain sectors will have a bigger weight sometimes. So, we select the securities one at a time; we build a model and we make individual recommendation for each security. We come up with analysis about the economics of the property type and the financial model; we evaluate what the cash flows are likely to be. Then we come up with a discounted format of what we think the asset is worth today. We do that for every REIT or security that we own. Then each recommendation is reviewed by all the members of the group.
Q: How important is the macroeconomic environment? Do you look for themes or trends?
A: There are three "environments" that you need to be aware of: 1) the real estate cycle for the property you are evaluating; 2) the macro environment which can impact demand 3) the interest rate environment. There are inter-relationships between all three of these factors.
Regarding individual themes, we have evaluated all the individual property types historically. We have ranked them from the most consistent, highest-quality property type, to the most cyclical, lowest-quality, commodity property type. To quantify the quality, we need to look at which property type is likely to generate the most consistent, least-cyclical, growing stream of cash flow. That's our goal on the quality metric.
Within the individual property types, there are also factors that are indicative of the quality. For example, in office real estate, the central business district in major gateway markets is perceived as a premium asset. For example, the General Motors Building in New York and the Salesforce Tower in San Francisco would be considered high-quality assets in office real estate. On the other end, a suburban office park in a non-land constrained area could be viewed as more of a commodity type of property.
So, we look for the highest quality property type not only in the absolute sense, but also within the specific property type. Every recommendation that we bring forward has some measurement of quality on both of these formats.
Q: How does the analyst team work? What is the decision-making process?
A: There are four analysts and there is some overlap in the property types they cover. Retail and office real estate are large areas, so two people may work on them. The primary coverage is assigned to one analyst, who regularly updates the group on the developments in that property type, but everyone is free to make recommendations when he or she finds opportunities. Generally, it is a process where the analyst makes a recommendation, that includes a write-up on the future outlook for this property type, an outlook for this specific portfolio, his or her expectations for earnings, and a cash flow model that we use for valuation purposes.
Then the group discusses the recommendation. We often poke on areas such as the outlook for competitive supply, the effectiveness of the company at re-leasing the existing space, the re-leasing spreads, etc. We check if the qualitative argument stands up to the quantitative result that we see and expect for the future. Then everyone in the group votes. Overall, it is a group process. We don't need to be unanimous, but we need a majority vote to make a decision.
Q: Could you give some examples that illustrate your research process?
A: Healthcare REITs represent one of the large real estate areas and there are different variations of healthcare REITs. One group is related to senior housing, which could be everything from nursing homes to assisted living facilities or independent living. Another group, which is a small subset of healthcare REITs, is the research facilities like lab spaces. A third group is medical office buildings such as outpatient surgery centers. They are not in the hospitals, but provide doctor's visits, minor medical care and outpatient surgery. The final and largest part of the industry is the large conglomerates, which own pieces of all the other three groups.
Right now we don't want a lot of exposure to senior housing, although the demographics will eventually be a tail-wind. As the population is aging and there are many people in their 70s, the average age of the people in these facilities has been increasing as well. However, many new facilities are being built in anticipation of this growing demographic trend. We feel that there is too much incoming supply for the level of current demand and that's not good for pricing. So, we avoid that segment of the market. We have limited exposure to the area and we want to deemphasize it because of our expectations.
However, we have a reasonable exposure in other segments, such as medical office buildings and lab space. We believe that they are attractively valued in absolute terms and are in the right place from a qualitative or strategic perspective. That's where we want to have exposure.


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Gunmen in Aden force shopkeepers to pay arbitrary taxes
Almasdar Online - Newsroom SATURDAY, 23 MAY, 2020 - 09:45 PM
Gunmen raided a number of shops in two of the largest commercial areas in Sheikh Othman district, in the north of the interim capital Aden district on Friday, and forced business owners to pay extortionate and illegal taxes.
One of the shop owners and multiple eyewitnesses told Almasdar Online that the gunmen broke into a number of food stores in the Al-Silah commercial area, in addition to multiple electronics stores in Abdul Qawi neighborhood, and demanded that the owners pay them money as "taxes" or else they would close their stores.
According to eyewitnesses, some shopkeepers initially refused to pay the armed men, saying the extortionate taxes are illegal, which caused one of the gunmen to threaten the use force if they were not paid.
The shop owner said that a large number of shops were forced against their will to pay about 30,000 to 40,000 Yemeni riyals (about $50 to $65).
Several of the armed men were masked, and according to the sources they were wearing civilian clothes and presumed to be locals.
Aden continues to suffer from instability following the battle in the city in August between the government of Yemen and the UAE-backed Southern Transitional Council, the latter of which has maintained de-facto control of the city since August 10, 2019.
Edited by Alkhatab Alrawhani
Aden STC Yemen war
In Ibb, alternative qat markets ease traffic congestion, but may not slow COVID-19 outbreak
After COVID-19 cover-up, Houthis acknowledge spread and enact stricter measures


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Q: reset a datetime jtextfield to "" by clicking on a jbutton and write it to sql server table column I have a JButton called ApprovalDate and on clicking it, a date picker frame opens and we can pick any date (which sets the jtextfiel's value) and write it to sql server table column.
I have another jbutton called Reset and on clicking it, I am able to clear the jtextfield, but when I try to write it to sql server table column, the record is not updated.
SimpleDateFormat sdf1 = new SimpleDateFormat("yyyy-MM-dd hh:mm:ss.S");
SimpleDateFormat sdf2 = new SimpleDateFormat("MM-dd-yyyy");

ActualApproval = jtfActualApproval.getText().trim();

 Calendar cal = Calendar.getInstance();

 cal.setTime(sdf2.parse(ActualApproval));

 ActualApproval = sdf1.format(cal.getTime());

 jbnReset.addActionListener(new ActionListener()   // Reset button's action listener
 {
            public void actionPerformed(ActionEvent e)
            {
                    jtfActualApproval.setText("");     //jtextfield to be reset
            }
    });

 jbnActualApproval.addActionListener(new ActionListener()   // to open a date picker
 {
         public void actionPerformed(ActionEvent e)
         {
                 jtfActualApproval.setText(new DatePicker(appFrame).setPickedDate());
         }
});

I am not able to write "" as date field  to ms sql server table column

A: Most likely your database won't accept "" as a value for a DateTime-column.

redpajama_set_name: RedPajamaStackExchange


Several media people have inquired if we should expect a cyber strike against the North Korean nuclear program, or why such strike didn't happen already. Here is my answer.
A cyber strike against North Korean nuclear assets is highly unlikely, and here is why.
I don't assume that North Korea uses similar digital control systems in their enrichment plants as Iran. As I have analyzed in To Kill a Centrifuge, the Iranian control systems are unique because they are mostly used as a protection system which allows Iran to operate unreliable centrifuges. Neither Urenco (the mother of all enrichment technology) nor Pakistan needed such an oversophisticated protection system, because their centrifuges didn't crash all the time. I assert that North Korea managed to manufacture reliable rotors just like Pakistan, thereby saving the need for a digital protection system. But no digital control, no cyber attack surface.
Also keep in mind that anybody aiming to disrupt North Korea's enrichment program is several years late. The hermit kingdom has enough weapons-grade uranium in stock to credibly threaten a nuclear attack. If they are using digital control for critical functions of their missile launch and control systems, they must be nuts. Let's just assume they are aware of US cyber infiltration capabilities, especially after the Sony attack, and rely on old-style analog control for their nuclear weapons.


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Alexandre Leblanc de Ferrière, (18 October 1771, Bar-sur-Seine – 23 February 1848), was an 18th–19th-century French playwright, journalist, printer, publisher and writer.

Biography
The printer and director of L'Arlequin, journal de pièces et de morceaux (1799), a journalist by the daily Le Monde (1796-1798), the head of the statistical bureau of the Interior ministry (1803), responsible for the Annales de statistique française et étrangère (1803-1804) and the Archives statistiques de la France (1804-1805), an editor for the Analyse de la statistique générale de la France published by the French Interior ministry (1803-1804), he wrote an Annuaire de Paris et des environs, published in 1838. His theatre plays were presented on the most important Parisian stages of the 18th and 19th centuries, including the Théâtre de l'Ambigu, the Théâtre de la Gaîté, the Théâtre Le Temple, and the Théâtre du Vaudeville.

Works

1776: Les Souliers mordorés ou la Cordonnière allemande, opéra comique in 2 acts
1797: Arlequin-décorateur, comédie-parade in 1 act and in prose, mingled with vaudevilles, with Nicolas Gersin and Antoine Année
1803 – 1804: Analyse de la statistique générale de la France
1805: Holkar et Palamys, ou Les Anglais dans l'Indoustan
1806: Un voyage à Versailles, 2 vols.
1806: Ester, with Philippe-Aristide-Louis-Pierre Plancher de Valcour
1807: Un Conte des mille et une nuits, opéra comique in 1 act, music by Charles-Henri Plantade
1810: Grotius, ou le Fort de Loevesteen
1811: Charlemagne, ou les Grands jours de l'Empire français
1811: Favart à Bruxelles, comédie-vaudeville in 1 act
1812: Amour et loyauté, ou le Mariage militaire, comedy in 1 act, mingled with couplets, with Richard Fabert
1812: Arlequin-Lucifer, ou Cassandre alchimiste, folie in 1 act mingled with couplets, with Fabert
1813: Archambaud ou Amour et devoir, melodrama in 3 acts
1813: La Coutume écossaise ou Le Mariage sur la frontière, comédie-vaudeville in 1 act, with Charles Rondeau
1814: Les Trois talismans, melodrama in 3 acts and extravaganza
1816: Éléonore de Lusignan, melodrama in 3 acts, with Jean Edme Paccard
1816: Marguerite de Strafford, ou le Retour à la royauté, melodrama in 3 acts, in prose and extravaganza, with Desprez
1816: Le Mariage sous d'heureux auspices, vaudeville in 1 act, with Desprez
1816: Opinion sur le divorce considéré sous le rapport de la religion et des mœurs
1817: Inès, ou les Devoirs d'un roi, melodrama in 3 acts and extravaganza
1817: Hassem, ou la vengeance, melodrama in 3 acts
1818: Les Deux ambitions
1818: L'Incendie du village, ou les Représailles militaires, melodrama in 3 acts, extravaganza, with Jean-Baptiste Dubois
1819: Grégoire à Tunis, ou les Bons effets du vin, vaudeville in 1 act, with Aimé Desprez
1822: L'Actrice en voyage, vaudeville in 1 act, with Carron de Morcourt and Gaspard Tourret
1822: Les Deux baillis, ou le Mariage par procuration, comedy in 1 act, in prose
1825: La Fille du musicien, drama in 3 acts, with Edmond Crosnier
1825: La Comtesse de Tarascon, ou Dix années d'absence, anecdote du XIIIe siècle
1831: L'Hôtel des princes, opéra comique in 1 act, music by Eugène Prévost
1834: Jane Gray, drama in 3 acts and 5 tableaux, music by François Bellon, preceded with 6 juillet 1553, prologue in 1 act
1837: Annuaire de Paris et de ses environs dans un rayon de dix lieues
1838: Les Étouffeurs, drama in 2 acts, with Charles Foliguet
1838: Paris et ses environs, description historique, statistique et monumentale
1842: Lequel ?, comédie-vaudeville in 1 act, with Louis Berthier and Pierre Tournemine
1845: Introduction à l'étude philosophique de la phrénologie

Bibliography
 Joseph Marie Quérard, La France littéraire, ou Dictionnaire bibliographique des savants, 1829, (p. 114)
 Jean-Dominique Mellot et Élisabeth Queval, avec la collaboration d'Antoine Monaque, Répertoire d'imprimeurs-libraires (c. 1500 – c. 1810), Service de l'Inventaire rétrospectif des fonds imprimés de la Bibliothèque nationale de France, 2004.

External links
 Alexandre de Ferrière on Data.bnf.fr

1771 births
1848 deaths
People from Bar-sur-Seine
19th-century French journalists
French male journalists
18th-century French dramatists and playwrights
19th-century French dramatists and playwrights
French printers
French publishers (people)
19th-century French male writers
18th-century French male writers


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Home Chemistry & Physics Chemical data mining boosts search for new organic semiconductors
Chemical data mining boosts search for new organic semiconductors
Both the carbon-based molecular frameworks and the functional groups decisively influence the conductivity of organic semiconductors. Researchers at the Technical University of Munich (TUM) now deploy data mining approaches to identify promising organic compounds for the electronics of the future.
Credit: C. Kunkel / TUM
Producing traditional solar cells made of silicon is very energy intensive. On top of that, they are rigid and brittle. Organic semiconductor materials, on the other hand, are flexible and lightweight. They would be a promising alternative, if only their efficiency and stability were on par with traditional cells.
Together with his team, Karsten Reuter, Professor of Theoretical Chemistry at the Technical University of Munich, is looking for novel substances for photovoltaics applications, as well as for displays and light-emitting diodes — OLEDs. The researchers have set their sights on organic compounds that build on frameworks of carbon atoms.
Contenders for the electronics of tomorrow
Depending on their structure and composition, these molecules, and the materials formed from them, display a wide variety of physical properties, providing a host of promising candidates for the electronics of the future.
"To date, a major problem has been tracking them down: It takes weeks to months to synthesize, test and optimize new materials in the laboratory," says Reuter. "Using computational screening, we can accelerate this process immensely."
Computers instead of test tubes
The researcher needs neither test tubes nor Bunsen burners to search for promising organic semiconductors. Using a powerful computer, he and his team analyze existing databases. This virtual search for relationships and patterns is known as data mining.
"Knowing what you are looking for is crucial in data mining," says PD Dr. Harald Oberhofer, who heads the project. "In our case, it is electrical conductivity. High conductivity ensures, for example, that a lot of current flows in photovoltaic cells when sunlight excites the molecules."
Algorithms identify key parameters
Using his algorithms, he can search for very specific physical parameters: An important one is, for example, the "coupling parameter." The larger it is, the faster electrons move from one molecule to the next.
A further parameter is the "reorganization energy": It defines how costly it is for a molecule to adapt its structure to the new charge following a charge transfer — the less energy required, the better the conductivity.
The research team analyzed the structural data of 64,000 organic compounds using the algorithms and grouped them into clusters. The result: Both the carbon-based molecular frameworks and the "functional groups," i.e. the compounds attached laterally to the central framework, decisively influence the conductivity.
Identifying molecules using artificial intelligence
The clusters highlight structural frameworks and functional groups that facilitate favorable charge transport, making them particularly suitable for the development of electronic components.
"We can now use this to not only predict the properties of a molecule, but using artificial intelligence we can also design new compounds in which both the structural framework and the functional groups promise very good conductivity," explains Reuter.
Materials provided by Technical University of Munich (TUM). Note: Content may be edited for style and length.
Christian Kunkel, Christoph Schober, Johannes T. Margraf, Karsten Reuter, Harald Oberhofer. Finding the Right Bricks for Molecular Legos: A Data Mining Approach to Organic Semiconductor Design. Chemistry of Materials, 2019; 31 (3): 969 DOI: 10.1021/acs.chemmater.8b04436
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text:
Tjechovskaja (ryska: Чеховская) är en tunnelbanestation på Serpuchovsko-Timirjazevskaja-linjen i Moskvas tunnelbana.

Stationen invigdes den 31 december 1987 och var i ett års tid linjens norra slutstation. Nedgången till stationen finns vid Pusjkintorget, medan stationen är namngiven efter författaren Anton Tjechov.

Stationen är en pylonstation på 62 meters djup.

Byte
Vid Pusjkintorget finns förutom till Tjechovskaja nedgångar också till stationerna Tverskaja på Zamoskvoretskajalinjen (gröna linjen) och Pusjkinskaja på Tagansko-Krasnopresnenskajalinjen (lila linjen), och det går att byta mellan alla tre stationerna via direkta passager under jord.

Se även
 Moskvas tunnelbana
 Lista över Moskvas tunnelbanestationer

Moskvas tunnelbanestationer
Järnvägsstationer invigda 1987
1987 i Sovjetunionen


Leverage the power of infrared light to capture a 3D model of your body with the Home Body Scanner from Naked Labs. The scanner itself is built into an attractive smart mirror with sensors that measure important metrics and calculate measurements. An integrated app allows you to track your progress. The Naked body scanner is designed to help you visualize your progress and body fat percentage as it happens, with a focus on weight loss, performance and re-composition. You'll be able to literally watch your body as it changes each day.


This poem was written just as me following an inspired thought … but I think it came out pretty well! And – GASP! – it's SHORT!
Or intricate like water colour masterpiece.
Continues to paint ecstasy upon naked flesh.


text:
ai:qian.weimao se:00005006 0 100 mathjax
Yang, Yue-Ying; Qian, Wei-Mao; Xu, Hui-Zuo
Sharp bounds for Sándor-Yang means in terms of one-parameter family of bivariate means. (English) Zbl 1435.26040
J. Math. Inequal. 13, No. 4, 1181-1196 (2019).
MSC: 26E60
\textit{Y.-Y. Yang} et al., J. Math. Inequal. 13, No. 4, 1181--1196 (2019; Zbl 1435.26040)
Xu, Hui-Zuo; Qian, Wei-Mao
Sharp bounds for Sándor-Yang means in terms of quadratic mean. (English) Zbl 1406.26018
\textit{H.-Z. Xu} and \textit{W.-M. Qian}, J. Math. Inequal. 12, No. 4, 1149--1158 (2018; Zbl 1406.26018)
Qian, Wei-Mao; Zhang, Xiao-Hui; Chu, Yu-Ming
Sharp bounds for the Toader-Qi mean in terms of harmonic and geometric means. (English) Zbl 1358.26025
J. Math. Inequal. 11, No. 1, 121-127 (2017).
MSC: 26E60 33C10
\textit{W.-M. Qian} et al., J. Math. Inequal. 11, No. 1, 121--127 (2017; Zbl 1358.26025)
Chu, Yu-Ming; Qian, Wei-Mao
Sharp Lehmer mean bounds for Neuman means with applications. (English) Zbl 1339.26081
MSC: 26E60 26D05 26D07
\textit{Y.-M. Chu} and \textit{W.-M. Qian}, J. Math. Inequal. 10, No. 2, 583--596 (2016; Zbl 1339.26081)
Qian, Wei-Mao; Chu, Yu-Ming
Refinements of bounds for Neuman means in terms of arithmetic and contraharmonic means. (English) Zbl 1333.26036
J. Math. Inequal. 9, No. 3, 873-881 (2015).
\textit{W.-M. Qian} and \textit{Y.-M. Chu}, J. Math. Inequal. 9, No. 3, 873--881 (2015; Zbl 1333.26036)
Qian, Wei-Mao; Shao, Zhi-Hua; Chu, Yu-Ming
Sharp inequalities involving Neuman means of the second kind. (English) Zbl 1314.26038
\textit{W.-M. Qian} et al., J. Math. Inequal. 9, No. 2, 531--540 (2015; Zbl 1314.26038)
Full Text: DOI Link
Qian, Weimao (6)
Chu, Yuming (4)
Xu, Huizuo (2)
Shao, Zhi-Hua (1)
Yang, Yueying (1)
Zhang, Xiaohui (1)
9, No. 3 (2015) (1)


text:
Planet of Sound	 July 16, 2017 August 26, 2017
Planet Of Sound: Radio Birdman and the ANU Bar Finale
Despite the 'controversy' surrounding the line-up for the final ANU Bar show on Saturday June 17, I attended anyway and soaked up the grungy vibe for one last time. This was accentuated when I entered the toilets and noticed a puddle of brown water on the floor, and remembered how my knees once got wet from something similar while my head was in the bowl from too many beers the night before a major exam – so many memories.
The music was okay and it was fitting that a few bands acknowledged all the people who over the years worked tirelessly to put on shows at the ANU including promoter Pete Spicer and bar manager Tony Kirk – these dudes presided over a golden age when a mouth-watering array of bands hit the ANU stage on a regular basis. The standout act at this show was hip-hop artist Citizen Kay who integrated colourful wordplay with well-placed funk samples and live drums – a reminder that good quality local talent is out there and worthy of recognition, particularly as we are talking about small Canberra fish in a big cultural sea. Citizen Kay performed a great set that made for one of my rare encounters with hip-hop at the ANU. Another of note being the fantastic line-up of Public Enemy and Ice-T when all punters were waved through with metal detectors as if to enforce concerns that a gang war could break out on the muddy shores of Sullivans Creek at any moment.
"How fantastic it would have been if Radio Birdman or New Christs had headlined the final ANU show if only because Birdman and co had inspired so many acts gracing the ANU stage over the years."
The fact that I was still fired up from having seen Australian punk rock originators Radio Birdman perform a highly energised set at the Enmore Theatre in Sydney the night before, drove the need to consume ever more of the One Fifty Lashes pale ale on offer at the ANU while I also recalled having seen Birdman perform twice before in Canberra. On both occasions the band let loose with hardwired rock 'n' roll that was a joy to behold. The band's second visit was timed to promote the criminally underrated 2006 'comeback' album Zeno Beach that got the juices flowing just like those early days at the Oxford Funhouse when Birdman's mission was to introduce combustible Detroit styled hard rock into a music scene more interested in Olivia Newton John and Daryl Braithwaite's chest hair.
A few years after that second Birdman show at the ANU vocalist Rob Younger returned and turned out a highly charged performance with side project New Christs to a miserable turnout of about 20 people. When I interviewed Younger shortly after he mentioned that it was unlikely he would return to Canberra because the audience size was pitiful and I agreed with him. But when I learnt New Christs would be touring in support of the first rate 2014 album Incantations I hoped Younger's disdain had lessened and contacted both his management and the Transit Bar in the hope of facilitating a Canberra show, but little came of it. On reflection, how fantastic it would have been if Radio Birdman or New Christs had headlined the final ANU show if only because Birdman and co had inspired so many acts gracing the ANU stage over the years and they would have seen this prestigious venue out in style.
But knowing this would never happen I instead travelled to Sydney and witnessed Radio Birdman play a blistering set at the Enmore Theatre with fellow long road travellers Died Pretty and Kim Salmon as supports. There has been a renewal of interest in Birdman in recent years and the band can now quite easily fill the Enmore. The audience was a mix of old timers adorned in t-shirts first worn at the Oxford Funhouse in 1977 and curious younger fans wanting to see what all the fuss is about – and those of us somewhere in between. Some felt the need to record the show on mobile phones including one seemingly enthused fan near the front who was positioned quite close to me and kept blocking my view with her phone. I forgave her though because she kept turning to look at me with a flick of her hair that smelt of coconut oil and moved in synch with me and the sound to suggest she found the whole thing as interesting as I did. The band opened with a heated cover of the 13th Floor Elevators classic 'You're Gonna Miss Me,' and once that essential link with first rate 60s garage rock had been established, Birdman ripped through a stack of nuggets from the early years, played hard and fast. The few tunes from 'comeback' album Zeno Beach were bafflingly less well received as these songs were as good as anything else the band had recorded and the girl with the coconut scented hair by now leaning quite heavily into me didn't complain when I yelled out for more from that superb album. This show was the white heat of the greatest punk rock and I've now got the t-shirt to prove it. Birdman could have seen the ANU Bar out on a high – maybe next time.
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text:
The making of the cover for The Venetian Contract by Marina Fiorato
The illustrator reads the novel and, inspired by the read, draws a sketch.
Getting the sketch approved by the art director and presenting it to the customer.
Customer: Awesome concept, but I have to think about whether it's really fitting or not. Definitely, no black background: the story is light and airy as stained glass arabesques with frequent mentioning of the sea and water in general.
Smoothing out some details of the image and trying different backgrounds.
Customer: I prefer the turquoise background and I'd like more of Yana's signature fine elements in the center. Need to see how it will work with the title.
The type designer calligraphs the title and the illustrator adds details.
The customer chooses the bottom version. Finishing up the calligraphy, making the black horse switch places with the gray, adding the publishing house logo, and typesetting the cover.


text:
Camille Abily, född 5 december 1984 i Rennes, är en fransk fotbollsspelare som spelar för Lyon i Division 1 Féminine. Hon spelar i första hand som offensiv mittfältare. Abily gjorde sin landslagsdebut för det franska landslaget den 26 september 2001 i en match mot Nederländerna.

Källor

Externa länkar

 Profil på Fédération Française de Footballs sida

Franska fotbollsspelare
Tävlande vid olympiska sommarspelen 2012 från Frankrike
Tävlande i fotboll vid olympiska sommarspelen 2012
Tävlande vid olympiska sommarspelen 2016 från Frankrike
Tävlande i fotboll vid olympiska sommarspelen 2016
Kvinnor
Födda 1984
Levande personer
Personer från Rennes