Your body is a receiving station for secret messages from Spirit.
Stop thinking about your body, and start listening to it!
All your history and negative programming is lodged in the cells of your body.
Using this 28-Day jump-start health program based on Denise Linn's original Soul Coaching® Program – you'll unweave hidden blockages within your DNA to initiate your natural life-force energy and your body's spiritual radiance!
Activate powerful cellular rebalancing of your body.
Realize why you were born with your specific body.
Align your body with your life purpose.
Uncover the spiritual lessons you're receiving from your body in this lifetime.
Learn the mystical correlation between your body and your life.
Understand how clutter clearing can heal health challenges.
begin to claim your luminous, vital glorious body.
You will receive support and guidance from both Gretchen and Dr. Jerri! As your intuitive Soul Coaches®, we are here to help you access your inner voice and empower you to create the life you truly want to live- full of joy, love, happiness, and success.
You will have the opportunity to receive daily feedback and support from us and other group members through a private Facebook group.
Listen to what Gretchen Hogg, International Soul Coach® has to say about the benefits of Unlock The Secret Messages of Your Body!
Unlock The Secret Messages Of Your Body! Created by Denise Linn, author, teacher, and speaker.
This 28-Day Program – which is based on her original Soul Coaching® program – takes you on a heartfelt journey into the vast inner universe of your body, where mysteries dwell as great as any that can be found in the heavenly bodies above. There are wondrous secrets in your cells, glands, and organs that can unveil countless insights about your life. As the messages are revealed to you, your radiance expands and your body becomes lighter and freer. Your body is a receiving station that is constantly absorbing deeply meaningful messages from the world around you. However, you can't hear those messages if your body is clogged with inner static. This interference doesn't just come from lack of exercise or an overload of junk food; in the deepest sense, it's a result of self-imposed, limiting beliefs and fears that have become lodged in your energy field.
Once you have committed yourself to the program, life seems to unfold in a remarkable, almost magical, way. Declare that you are ready to discover your authentic self, and are willing to dedicate one month of your life to doing it, and the loving forces of the universe will coalesce to propel you in the direction of your destiny. Synchronistic events and seeming "coincidences" begin to expand exponentially in your life.
The aim of Soul Coaching is to align your inner spiritual life with your outer life. It helps you to clear away mental and emotional clutter so you can hear the messages from within. It also helps you to discover your purpose so you can design a life that supports that purpose.
Everything is energy – including your body! The choices you make, the thoughts you think, the people you spend time with, the food you eat, …all of these affect the energy fields that make up your body. You will learn what you can do to release the internal mental and emotional stagnation to become more vibrant.
Everything is in a constant state of change. – No matter what shape your body is in, how overweight it is, or what health challenges you're facing, you can transform your health.
Everything has consciousness. – Every gland, organ, and cell in your body has an awareness with which you can communicate and even influence.
By utilizing the elemental energies of Air/intellectual, Water/emotions, Fire/spirit, and Earth/physical; this program allows you (in as little as 10-15 minutes per day) to connect with your spiritual source and find deeper meaning, purpose, plus add ceremony and sacredness to your everyday life while facing fears, clearing blockages and addressing non-serving beliefs or patterns.
Through practical lessons, 28 daily guided audio meditations, 28 powerful affirmations, creative projects ideas for healing and/or manifesting you are encouraged to truthfully explore your life. You'll experience how to challenge your negative beliefs, face your fears, become even more motivated and inspired, leaving you feeling more balanced, whole and focused like never before! Learn to live more in the now and have clarity to pursue the life of your dreams.
Participants find that once they have committed themselves to the program, their life begins to unfold in positive ways! If you are feeling drawn to the program, trust that it is your time to invest in yourself and this magical journey to your soul.
How Can I Do the Program with My Busy Life?
No matter how busy you are or how hectic your life is, you can do this program. It is designed so anyone can do it. There are daily lessons, which are divided into three levels. You choose the level at which to participate.
Level One: "Commitment to Change" Includes doing the Level One exercises usually takes 15-30 minutes a day.
Level Two: "Going for It" Includes doing both Level One and Level Two exercises and will usually take 30 -60 minutes a day.
Level Three: "Playing Full Out" Includes doing the Level One, Level Two, and Level Three exercises, and it takes as long as it takes.
Most of us, when we were growing up were taught to judge ourselves harshly if we didn't do things perfectly. You don't have to be perfect for this program to work miracles in your life. It works in spite of feeling you didn't do it right.
It is suggested for you to keep two journals. The first journal is your PROCESS Journal. It is for mental and emotional clearing; it can be used to express your feelings and to write insights incurred as a result of the daily lessons. A downloadable template for your Process Journal is included.
You are welcome to use any type of journal. The second journal is your JOY Journal. In this journal your might include writings, collages, drawings, poetry, pictures, etc. The goal is to capture the Joyful moments of each day. A downloadable template for your JOY Journal is included.
Every day you will be given a carefully chosen affirmation that is appropriate to the lesson for the day. Affirmations work! They work because what we focus on is often what we create for ourselves.
Official Coaching package with Soul Coach® Gretchen: daily coaching and mentoring via a private Facebook group, downloadable/printable lessons, 3 levels of mastery, 28 daily affirmations, downloadable audio soul journey meditations, and how to create an altar, and so much MORE.
$197 plus all the bonuses.
All participants will receive a beautiful meditation, "Cultivating an Attitude of Gratitude," by Soul Coach® Gretchen Hogg.
All participants will receive the "QUEST: Beyond the 28 Days" Activity. Enjoy a unique, guided meditation for your QUEST that has been specially recorded for you by hypnotherapist Gretchen Hogg. This activity will enable you to anchor in all the work you have completed in the 28- Day Program.
All participants will be encouraged to participate in the PRIVATE Facebook group community to share their progress, receive daily inspirations on their journey and meet new friends & like minded/hearted people on similar paths.
Projects: Set personal intentions, make sacred contracts, and create a sacred altar.
WEEK ONE ~ AIR WEEK ~ Attain clarity through cleansing mental clutter.
WEEK TWO ~ WATER WEEK ~ Create inner peace by emotional clutter clearing.
WEEK THREE ~ FIRE WEEK ~ Connect with your beautiful intimate Spirit within.
WEEK FOUR ~ EARTH WEEK ~ Clear the Physical Clutter – Bring balance to life.
The value of this program is $797!
WEEK ONE ~ AIR WEEK ~ Clearing Your Mental Body. Clearing Mental Blockages to Excellent Health In the first seven days of the program, you'll focus on clearing mental blockages and barriers that hinder your well-being. You'll also conduct a health assessment and an inner and outer clutter clearing. If you choose only one thing to do for your health, it should be to learn to breathe deeply and fully. During this week, simply focus on your breath. Fill your lungs as much as possible and then exhale as if you're releasing air from a balloon. Throughout this week focus your awareness and attention on the air that surrounds you. The Air element is also associated with inspiration, literally to inspire. This can take the form of what you read, what you think about, and even what you listen to.
Remember to write down what's great about each day in your Joy Journal.
Day 4. What Are Your Inner Beliefs about Your Body?
WEEK TWO ~ WATER WEEK ~ Clearing Your Emotional Body Water is a great metaphor for emotions and the many transformations possible; from ice to mist or raging river to clear mountain stream, this is the week we cleanse and rejuvenate our soul. It's a myth that good people don't have negative emotions. However, emotions are truly negative if you suppress them or dump them on someone else. Carrying around excess baggage (unprocessed emotions) doesn't promote excellent health. During this week, drink plenty of water. Many health problems can be reduced or even eliminated if the body has enough fluid to cleanse and purify itself. Pay attention to the water that is all around you. As much as possible, share the emotions you experience this week with others, as it can have a powerful impact on your health.
Day 9. Is This Who You Are?
Day 10. What Are Your Energy "Zappers" and "Juicers"?
WEEK THREE ~ FIRE WEEK ~ Clearing Your Spiritual Body In the first seven days of the program, you focused on clearing barriers that hindered your health. Usually the greatest blockage is fear, and this is the week when you'll be confronting this emotion. The fastest way to transform your body is through action, but it's easy to hesitate to make changes because of fear—fear of discomfort, of failure, of the unknown, and even of success. Fire Week is the time to look at your fears and take action to overcome them. This week deepens your awareness of the light that's around and within you. Pay attention to the different types of lighting. Fire represents change and transformation, so this is the time to take risks and try relating to your body in different ways.
WEEK FOUR ~ EARTH WEEK ~ Clearing Your Physical Body – Bring balance to life. For and the week ahead, spend time focusing on the earth. When you are outside, for instance, pay attention to the ground beneath you. Even if you're walking on a sidewalk, take a moment to connect with the soil beneath the concrete. Be aware of the foods you eat that grow from the earth, especially root vegetables. Focus upon the intimate connection that your body has to Mother Earth and the fact that when you leave your physical self, it will again return to the earth.
WEEK ONE ~ AIR WEEK ~ Attain clarity through cleansing mental clutter. Like all journeys, you have to begin somewhere, so we begin where we are. Right now, in this moment, we assess our life keeping in mind that our evaluations of ourselves are not who we really are. You will learn about commitments to self, your values & beliefs and begin to explore your soul mission in life!
We look at clutter and how it affects our life and our energy and then start doing something about it either in baby steps or giant leaps, whatever you are ready for!
Day 4. Where Are You Now in Your Life?
WEEK TWO ~ WATER WEEK ~ Create inner peace by emotional clutter clearing. Water is a great metaphor for emotions and the many transformations possible; from ice to mist or raging river to clear mountain stream, this is the week we cleanse and rejuvenate our soul. We discuss turning points and recurring emotions and how they affect life. It's just like looking at a map and deciding to go in another direction to an even better place but to get there we might have to pull out the magnifying glass to look at the fine print or even go back to previous maps that may have been created for us!
Travelling without the right partners might take away from the journey so we lovingly take a look at your relationships, your patterns and how you relate to the world and your Creator. You will learn how to slow down, watch for signs, release victim like thinking so you can choose your best life and go for it!
WEEK THREE ~ FIRE WEEK ~ Connect with your beautiful intimate Spirit within. On most journeys one could imagine the travelers late at night stopping by the campfire and sharing stores about their travels of the day, well not this one, don't get too comfy just yet, think walking on fire (metaphorically speaking) think confronting fears, taking a risk, stepping out of your comfort zone! Flames move and dance, as will you. We are going to take to take the "what if's" and transform them into 'how can I's" so you can rise from the ashes and fly. As we rise up we will tap into our creativity and add color, expression, abundance to our Spirit.
WEEK FOUR ~ EARTH WEEK ~ Clear the Physical Clutter – Bring balance to life. Your beautiful Spirit needs a loving nurturing home a temple, and a sacred place it can be at one with and this is the week for defining the home for your soul. This journey will not end when you come home; it will allow you a new vehicle to commune with your soul. You will learn how to connect with nature to benefit your body, your home and soul. We look ahead, envision and create fabulous futures for you and members of the group then complete the week encircled in love with a heart of light!


Time: 6:00 p.m. until 8:30 p.m.
Come join us for Dr. Bray's training in an evidence-based approach to relieving stress and anxiety for parents of children with disabilities that they can in turn share with their own families. Also open to anyone who experiences a disability and struggles with anxiety. Instruction will be presented by Dr. Robert Bray, an experienced and licensed mental health professional who has traveled internationally, providing this training for over 20 years.


text:
Q: error in grunt-saas, even though saas is installed? I am using Mac OSX.
gem install saas is done.
ruby is also update.
still show Warning: spawn sass ENOENT
Couldn't understand why?

A: have you updated your xcode?
Here's what worked for me. From "iamcubcs"
https://github.com/oklai/koala/issues/679

*

*Open Terminal

*Install Homebrew:

 ruby -e "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/master/install)"

*Do not close Terminal, open Mac Appstore and check Update, install all XCode Command Line Tools updates OR in my case, XCode Command Line Tools started install automaticly throught Terminal right after step 2.

*Back to Terminal

*Install Ruby:

brew install rbenv ruby-build

*Install SASS gem:

sudo gem install -n /usr/local/bin sass

redpajama_set_name: RedPajamaStackExchange


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When it comes to choosing the right vacation, it can often be something of a difficult choice. After all, most of us don't get the chance to take a vacation more than a couple of times a year, if that, so finding the right trip to take can be a challenge. However, one of the most common mistakes that a lot of people make is that they end up choosing the same types of vacations and destinations over and over again, year after year, Now, there's nothing inherently wrong with this. After all, there's no reason why you shouldn't do whatever you like, it's your vacation after all. That being said, that kind of vacation does run the risk of getting pretty boring pretty quickly. That's why mixing up your vacation habits can reignite your vacation excitement. Doing something like a cruise can be a great way of keeping things fresh and different with you having the opportunity to experience so many new places. A common misconception is that you always have to pay full price for these holidays but actually, you can find various Cruise deals. So why not try something a little bit differently next time you decide to take a trip? You could do anything you like on your holiday. You might just want to go to the beach and relax but there are plenty of other things that you can do. Don't forget to also look at alternatives for how you are going to travel to your holiday destination. Are you going to drive, fly or even get a ferry? If you are thinking about getting a ferry to somewhere in Europe for example, then you could easily check out a site like ferryu who can help make this happen. Here are just a few alternative vacations ideas that you might want to try.
Being able to spend time in the ocean is definitely one of the very best things about a lot of vacations, but have you ever thought there must be more that you can do than just spend your time splashing around in the shallows. Well, you have then why not try kayaking for a change. You might think that kayaking on the ocean waves is going to be very similar to surfing but the truth is that they couldn't be more different. The control that the paddle of a kayak gives you means that you're able to do a whole lot more on the surf than you ever could on a board. However, be warned: this is one addictive hobby. It's the kind of thing that you could very easily get sucked into. You'll end up obsessing over different boards and spending your evenings reading a kayak paddle comparison to find the one that's perfect for you. This could end up being a great vacation but it could also become a seriously wonderful hobby too.
One of the problems with a lot of vacation for many people is that there doesn't seem to be any real middle ground between incredibly relaxing vacations where you just lounge around all day, and high octane thrill-seeking adventures. Well, if you're looking for something active that still lets you stop and smell the flowers then hiking might well be the perfect vacation for you. If you can find the right place to go hiking then not only do you get the chance to stay active but you'll also get to experience some of the most beautiful landscapes in the world. Not only that but it's a wonderful way to get away from all of the hustle and bustle of modern life and just recharge your batteries for a while.
If you're the kind of person who really takes the phrase "it's not the journey, it's the destination" to heart then a road trip might well be the perfect vacation for you. Being able to hit the road and see all kinds of different places in one vacation can be a great way to avoid getting bored while traveling. You not only get to choose where and when you go, but you get to take your accommodation with you every step of the way! There's a freedom to this kind of vacation that you really cannot get anywhere else. In fact, there are some people who love this way of life so much that they commit to it full time. Sure, that's probably not going to be what happens to you, most of us end up missing indoor plumbing too much, but it's a sign of just how exciting this kind of trip really can be. On a road trip it's all about creating memories for you and your family, even if you decide not to stay in the car, but stay in a hotel like the EVEN Hotel Eugene along the way.
Now, if hiking sounds fun but it all just seems a little too safe for your tastes, then why not kick things up a notch with a survivalist trip? Sure, things like a soft bed in a hotel room with a bar nearby are great, but if you want to really get away from the stress of the world, why not try your hand at being able to survive out in the wilderness with nothing but your wits to guide you. Sure, this isn't something that everyone is going to be into, but an aspiring Bear Grylls is going to find this kind of adventure one of the most fulfilling things there is. The sense of achievement at being able to actually take care of yourself in the wild is something that few other things could ever compare to. Of course, this is the kind of trip where you really do have to prepare for it as carefully as possible. Otherwise, you could end up in some serious trouble.
Of course, having to plan everything might be the reason that you're getting kind of bored and frustrated with your vacations. If that's the case then why not bring a little bit of spontaneity into your next trip. Instead of obsessively planning every single aspect of your trip, leave some things up to change. Just pack your backs, show up to the airport, and buy a ticket on the next available flight no matter where it's headed. Sure, you might end up somewhere totally bizarre that you would never have even considered visiting, but that's part of the fun. You could well end up discovering your new favorite place in the world!
Again, it's important to remember that you don't have to do any of these things. If what you really want out of a vacation is the chance to hang out on the beach and do nothing for a couple of weeks, then that's great! After all, life is tough enough without having to spend your time stressing over whether or not you're doing your vacation "wrong". However, if you find that some of the magic has gone out of some of your trips then at least now you've got some idea of the kinds of alternatives that are out there for you.


text:
Q: Convert doc to txt via commandline We're searching a programm that allows us to convert a doc or docx document to a txt file. We're working with linux and we want to start a website that converts user uploaded doc files. We don't wanna use open office/libre office cause we have bad experience with that. Pandoc can't handle doc files :/
Anyone have a idea?

A: You will have to use two different command-line tools, depending if you are working with .doc or .docx format.
For .doc use catdoc:
catdoc foo.doc > foo.txt

For .docx use docx2txt:
docx2txt foo.docx

The latter will produce a file called foo.txt in the same directory as the original.
I'm not sure which Linux distribution you are using, but both catdoc and docx2txt are available from the Ubuntu repositories, for example:
apt-get install docx2txt

Or with Homebrew on Mac:
brew install docx2txt

A: here is a perl project which claims to do it. I have done a lot of this by hand also, using XSLT on the document.xml. the Docx file itself is just a zip file, you can unzip it and inspect the elements. I will say that this is not hard to do for specific files, but is very hard to do in the general case, because of the lack of documentation for how Word internally stores things, and the variance of internal representation.

A: For doc files you may use antiword, it's available on Homebrew and Ubuntu.

A: You can also use pandoc:
Keep the layout (newline as in the visualization of the document):
pandoc -s mydocument.docx  -o ouput.txt

Newline only when the original text has a newline command:
pandoc --wrap=none -s mydocument.docx  -o ouput.txt


An attack on a mining site in Dan-Bukuru village, Bokkos Local Government Area of Plateau State, Sunday left four dead, reports say.
The attack reportedly followed arguments between two groups of miners earlier in the day.
"One of the groups left in anger after the argument and returned in the night with an attack," a security source said.
Two of the deceased according to him have been identified as natives of the mining host community.
One he said is a Berom native while the other has not been identified.
No suspect has been arrested but the four corpses as of the time of publishing this report were laying at the Bokkos Divisional Police Station.
Chairman of the LGA, Mr. Yusuf Machen when contacted hurriedly said, "I will call you back, I am at the DPO's office" and hung up.


text:
Калоя̀н (Йоа̀ница, Йоан II, Ioan II, Kalojan Asen, , гр.: Kaloiōannēs, Iōannēs) – "Ромеоубиеца" (* ок. 1170; † 1207) е цар на България от 1197 до 1207 г. от династията Асеневци. Той е най-малкият брат на българските царе Иван Асен I и Теодор Петър.

С цел да получи императорска титла от Светия престол, той влиза в кореспонденция с папа Инокентий III. Изпратен е кардинал Лъв, който коронясва Калоян за rex Bulgarorum et Blachorum, правейки го единствения български владетел с католическата титла крал.

Калоян се провъзгласявa за български отмъстител, приемайки прозвището Ромеоубиец по аналогия с Василий II Българоубиец.

Ранни години
Вероятно след обсадата на Ловеч от 1187 г. Калоян е пратен в Константинопол като заложник. Там прекарва около две години. Калоян успява да избяга от Византия към края на 1189 г. Оттогава цар Асен го държи постоянно при себе си. След убийството на цар Иван Асен I (Асен), цар Петър го назначава за помощник в управлението. Когато и той става жертва на заговор, Калоян изпреварва и отстранява заговорниците, и бива коронясан за български цар в началото на 1198 г.

Царуване

Българо-византийска война (1201)

През 1199 г. Калоян организира антивизантийска коалиция, привличайки на своя страна назначения за управител на Пловдивската област – Иванко, и Добромир Хриз – самостоятелен владетел в Македония. Иванко бива заловен чрез измама от императора и хвърлен в тъмница, а Добромир Хриз предпочита да развали съюза си с Калоян заради сделка с Византия. Създадена е втора коалиция (1201 г.), включваща управителя на Смолян Йоан Спиридонаки, братовчеда на василевса – Мануил Камица и Добромир Хриз, когото Калоян успява отново да привлече на своя страна.

Калоян започва военни действия срещу Византия, нахлувайки в Тракия. Бързо бива превзета силната тракийска крепост Констанция (дн. Симеоновград). След това Калоян насочва армията си към Варна, последното владение на Византия северно от Стара планина. Тя е защитавана от голям гарнизон западни наемници. Българските войски обсаждат града и на третия ден (24 март 1201 г.) след щурм овладяват крепостните стени и нахлуват в него. Защитниците и управителите на Варна са вързани и хвърлени в рова на крепостните стени, като са засипани с пръст от българите. След като са погребани живи по този начин, Калоян си спечелва прозвището Ромеоубиец. В края на 1201 г. започват преговори за мир и той бива подписан през 1202 година. По силата на този договор на Калоян е признато правото да владее земите северно от Стара планина, но Византия категорично отказва да му признае царската титла.

Война с крал Имре (1202)
През 1202 г. унгарският крал Имре (Емерих, упр. 1196 – 1204) напада България и превзема оспорваните области Белград, Браничево и Ниш, като последната прехвърля в ръцете на своето протеже на сръбския престол, Вукан Неманич. Калоян отвръща през 1203 г., помагайки на Стефан Неманич да си възвърне сръбския трон (намалявайки влиянието на маджарите в региона) и отвоювайки Белградската и Браничевската области с помощта на кумански наемници.

Коронация
Българо-византийската война, разразила се още в началото на царуването на Калоян, е прекратена през 1202 г. със сключването на мирен договор. По същество той повторно признава законността на възобновеното Българско царство. Превземането на град Зара (Задар) от кръстоносците от Четвъртия кръстоносен поход през ноември 1202 г. и тяхното споразумение с Алексий IV Ангел (1203 – 1204 г.) да отвоюват бащиния му трон довежда до цялостна промяна на геополитическата ситуация на Балканския полуостров. Насочването им към Цариград и установяването им пред неговите стени през юни-юли 1203 г. принуждават византийския василевс Алексий III Ангел (1195 – 1203 г.) да потърси военната помощ на българите. В началото на юни 1203 г. за преговори в Търново е изпратен цариградският патриарх Йоан Каматир (1198 – 1206 г.), който влиза в общение с българския цар и църковния глава архиепископ Василий Ι (1186 – 1232 г.). В писмото си до папа Инокентий III (1196 – 1216), писано скоро след тези преговори, цар Калоян с гордост известява, че гърците изпратили при него своя патриарх, който от името на византийския император му направил следното предложение: "Veni ad nos, coronabimus te in imperatorem et faciemus tibi patriarcham, quia imperium sine patriarcha non staret", тоест "Ела при нас, ще те коронясаме цар и ще ти направим патриарх, защото царство без патриарх не бива".

Разбрал причината за готовността във византийските отстъпки за признаването на царското му достойнство и за патриаршията на българския църковен глава, цар Калоян отказва исканата му военна помощ и побързва да ускори водените преговори за сключване на уния с Римската църква. Той предпочита да бъде първоначално наблюдател на събитията край Босфора, като по този начин подпомага косвено техния злощастен за Византийската империя развой.

Още в края на 1199 г. Калоян получава писмо от папа Инокентий III, който се надява да присъедини България към лоното на Римокатолическата църква. По това време българският владетел води и преговори с Византия за признаване на царската му титла. Уверявайки се, че император Алексий III Ангел няма да удовлетвори исканията му, Калоян отговаря на папското писмо след около три години, като настоява за царска корона (а не кралска) и самостоятелна църква. Папството разчита чрез България да разшири влиянието си сред православния свят. През 1203 г. Калоян настоява пред Рим не само за царска корона, но и за патриаршеска титла на търновския архиепископ.

През есента на 1204 г. кардинал Лъв потегля за България, но бива задържан от маджарския крал Имре (Емерих), който заявява, че ще пропусне кардинала само ако получи областите Белград и Браничево. Папата обаче му припомня, че Калоян ще бъде коронясан "не върху чужда, а върху собствена земя" и го заплашва с отлъчване от църквата, ако не освободи пратеника му. На 15 октомври 1204 г. кардинал Лъв пристига в Търново. На 7 ноември той миропомазва архиепископ Василий за примас на Българската църква, а на следващия ден – 8 ноември 1204 г. – от името на папа Инокентий III провъзгласява Калоян за крал (rex Bulgarorum et Blachorum) и му връчва корона и скиптър. Калоян изпраща писмо до Инокентий III, че е коронясан за император, а първосвещеникът му – за глава и патриарх на българската църква. По този начин Калоян сключва уния (от лат. – съюз, обединение) и признава върховенството на католическата църква. Така и двете страни биват удовлетворени, а папската благословия и коронация придават голям авторитет на българския владетел в цяла Европа. Според архимандрит Павел Стефанов, унията има голямо влияние върху вътрешния живот на Българската църква. Тя обаче е отменена с решение на всеправославния събор в Лампсак през 1235 г.

Битки с кръстоносците (1204 – 1205)
През 1204 г. рицарите от Четвъртия кръстоносен поход, начело с френския рицар и граф на Фландрия и Ено Балдуин, нахлуват във Византия. Калоян им предлага своята помощ, но те я отхвърлят. На 12 април 1204 г. западните рицари превземат Константинопол и обявяват създаването на Латинската империя. Те отново отхвърлят предложената от цар Калоян подкрепа. Неочаквано ромейската аристокрация в Тракия се обръща за помощ именно към Калоян. Ромеите се заклеват да го приемат за свой владетел, ако им помогне да се избавят от властта на рицарите. Въстанието на гръцката аристокрация избухва в началото на 1205 г. Латинският император (коронясаният Балдуин I) тръгва на поход, за да накаже непокорните градове в Тракия, с всички войски, които има на разположение. Когато стига до Адрианопол (Одрин) на 29 март 1205 г., той вижда над крепостните стени да се вее знамето на цар Калоян. Рицарите обсаждат града, като се опитват да подкопаят крепостните стени. През това време те биват подложени на непрекъснати нападения от куманската конница.

На 14 април 1205 г. се провежда битката при Одрин, една от най-великите и значими битки в българската история, в която цар Калоян напълно разгромява кръстоносците. Битката започва с вихрена атака на куманите, които веднага след това демонстрират мнимо бягство, за да подмамят армията на рицарите. Част от кръстоносците се втурват да ги преследват, увличайки и други след себе си, включително и император Балдуин. Така куманите ги отвеждат до мястото, където в засада чака основната част от българската армия. Дотогава смятани за непобедими, западните рицари биват напълно разгромени, а в плен пада самият император. Той е отведен в Търново, където остава пленник в т.нар. Балдуинова кула в Царевец до края на дните си, когато е хвърлен от т.нар. "Лобна скала" в пропастта ("Лобната скала" била мястото за екзекуции в Търново).

След битката армията на Калоян започва да напада латинските владения на широк фронт. В опит да избяга от наближаващите български войски, в резултат на преумора, умира и вдъхновителят на IV кръстоносен поход, престарелият венециански дож Енрико Дандоло. Впоследствие, при засада в Източните Родопи е убит и кралят на краткотрайно просъществувалото Солунско кралство – Бонифаций Монфератски.

Според някои сведения през 1205 година Калоян сключва съюз с Иконийския султанат за съвместно настъпление срещу Константинопол, но то остава неосъществено.

Рицарите претърпяват още едно тежко поражение в битката при Русион (1206 г.), състояла се край крепостта Русион. При опитите за контраатака на брата на император Балдуин – Хенрих Фландърски, латинците успяват да навлязат в Източните Родопи и да опожарят селища в Северна Тракия, но това не променя военното статукво. В интерес на истината трябва да се признае, че Калоян се справя блестящо от стратегическа и тактическа гледна точка с Латинската империя, възползвайки се от добрите си взаимоотношения с римския папа на дипломатическия фронт, от съюза си с куманските племена и от тактиките за неутрализиране на численото превъзходство на рицарите чрез засади, маневри и нарушаване на бойния строй на изключително силните при открито фронтално нападение тежки рицарски конница и пехота.

Военната кампания през 1205 г. приключва с влизането на Калоян в Пловдив. Градът му бива предаден от пловдивските павликяни.

Война на изтребление в Тракия
В хода на военните действия обаче, гръцката провинциална аристокрация се отмята от съюза си с Калоян и преминава на страната на латинците, поради което българският цар започва война на изтребление в Тракия. В резултат на това Пловдив е разрушен и са извършени погроми над ромейското население в региона. Обсаждани са последователно Адрианопол, Димотика, два пъти Солун, превзет е Сяр, като се предполага, че Калоян използва за своя база Източните Родопи и рядко се оттегля северно от Стара планина.

През 1207 г. цар Калоян отново се отправя с голяма армия към Солун и обсажда града. В хода на обсадата обаче царят умира. За смъртта му съществуват различни хипотези: за естествена смърт или че е убит от първия си военачалник – куманския войвода Манастър. Възможно е също Калоян да става жертва на заговор, в който участва и съпругата му, куманката Анна-Анисия (Целгуба).

Гробът на цар Калоян
През 1972 г. в църквата "Свети Четиридесет мъченици" във Велико Търново е открит гробът на висш аристократ от Второто българско царство. Въпреки нестихналите и до днес научни спорове дали това погребение може да се отнесе към личността на цар Калоян, мощите биват пренесени с държавни почести до реставрираната църква "Свети Четиридесет мъченици". Цар Калоян е тържествено погребан с държавни почести на 19 април 2007 г.

Писмо на папа Инокентий ΙΙΙ до цар Калоян от края на юни 1205 г.

Семейство
Цар Калоян е брат на царете Иван Асен I и Теодор-Петър. Той е женен за куманската принцеса Анна-Анисия и има с нея две деца:
 Витлеем (Бетлеем, Вениамин) ?
 Мария († сл. 1216), омъжена 1209 г. за Хенрих Фландърски, латински император по това време.

За негов последник е избран Борил Асен, племенник на цар Калоян.

Изобразяване в културата
 Цар Калоян – опера на видния български композитор Панчо Владигеров, завършена през 1936 г.
 "Калоян – цар на българите" – исторически роман от 1958 година, автор Димитър Мантов.
 Калоян – български филм от 1963 година, режисьори Дако Даковски и Юри Арнаудов, и сценаристи Дако Даковски, Антон Дончев и Димитър Мантов.Ролята на цар Калоян е изиграна от Васил Стойчев.
 "Калоян" – драма от Камен Зидаров от 1968 година
 "Когато Калоян премина Хем" – исторически роман от Слав Хр. Караславов от 1974 година, трета част от тетралогията "И се възвисиха Асеневци".
 "Цар Калоян" – исторически роман от 2017 година, автор Бойко Беленски.
 "Неманичите, раждането на кралството" – сръбски сериал от 2018 година, създаден в чест на 800-тната годишнина от създаването на Сръбската държава и излъчен по РТС 1, където ролята на Калоян е изиграна от Димитрий Илич. В сериала помага на сръбския крал Стефан Първовенчани (изигран от Войн Цветкович) да се върне на трона през 1204 година. Режисьор е Марко Маринкович, а сценарист – Гордан Михич.

Изследвания и литература
 Стефанов, П., архим. Нов поглед към унията между Българската и Римската църква през XIII век. – в: Преславска книжовна школа, Т. V. Изследвания в чест на проф. д-р ист.н. Тотю Тотев. Отг. ред. В. Гюзелев и Хр. Трендафилов, С. 2001, 343 – 352.
 Овчаров, Н. Победите на цар Калоян 1197 – 1207. Историческият избор на България между православие и католицизъм. С. 2001; 2 изд. С., 2005 (Българска вечност).
 Йорданов, Й. Пътека към себе си. С., 2003, 58 – 62 (реконструкция на черепа на Калоян – 40 г., висок 1,88 м.)
 Гюзелев, В. Одринската битка от 1205 г. С., 2005.
 Игнатов, В. Цар Калоян. С., 2008.
 Павлов, Пл. Българското Средновековие – познато и непознато. В. Търново, 2008.
 Андонов, К. Военното дело и войската на българите в представите на Жофроа дьо Вилардуен, Робер дьо Клари и Анри дьо Валансиен. – В: Omnia vincit amor: Юбилеен сборник на НГДЕК в чест на проф. Василка Тъпкова-Заимова. Съст. В. Вачкова и Цв. Степанов. С., УИ, 2008.
 Андровски, И. Цар Калоян – победителят на кръстоносците. – В: Същият. Българско средновековие. С., Симолини, 2011,
 Превод на М. Войнов в: Латински извори за българската история. т. ΙΙΙ, с.363 – 364.

Източници

Външни препратки

 Образи на пълководци и владетели
 "За цар Калоян – воина, дипломата и държавника", БНТ, История.bg, 16 юли 2015

Монарси на Втората българска държава
Православни монарси
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redpajama_set_name: RedPajamaWikipedia


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redpajama_set_name: RedPajamaCommonCrawl


1. Vide RTI dt 29.2.12, appellant had sought copies of all complaints made by Shri Rajeev Aggarwal against the appellant since 2007 and copies of all documents in respect of the complaints.
2. CPIO/ITO Ward 25(1) vide letter dt 20.3.12, informed the appellant that the information sought are denied under section 8(1)(d) Notwithstanding anything contained in this Act, there shall be no obligation to give any citizen, information including commercial confidence, trade secrets or intellectual property, the disclosure of which would harm the competitive position of a third party, unless the competent authority is satisfied that larger public interest warrants the disclosure of such information; and section 8(1)(j) Notwithstanding anything contained in this Act, there shall be no obligation to give any citizen, information which relates to personal information the disclosure of which has no relationship to any public activity or interest, or which would cause unwarranted invasion of the privacy of the individual unless the Central Public Information Officer or the State Public Information Officer or the appellate authority, as the case may be, is satisfied that the larger public interest justifies the disclosure of such information: Provided that the information which cannot be denied to the Parliament or a State Legislature shall not be denied to any person. as income tax related details are personal in nature and not in public domain. Appellant was also informed that his case records were being transferred to ITO Ward 37(1).
3. An appeal was filed on 5.4.12, which was disposed of by FAA vide order dt 3.5.12, directing CPIO to dispose of the petition on merit. CPIO vide order dt 31.5.12, disposed of the same stating that it is a TEP and not complaint and hence cannot be disclosed.
4. Another appeal was filed on 13.6.12 which was disposed of by the FAA vide order dt 12.7.12.
5. Submissions made by the appellant and public authority were heard. CPIO submitted that the assessment process has been completed and along with the 1 assessment order, a demand notice and penalty notice were issued to the appellant. Appellant has since gone in appeal to CIT (Appeal), against the said assessment order. As the matter is pending before CIT (Appeal), PIO expressed reservation in providing a copy of the TEP. Appellant submitted that he is involved in a matrimonial dispute and the complaint filed against him is by the brother of his ex-wife. He further submitted that since the process of assessment is completed there is no issue if he is provided with a copy of the TEP and as it would not impact in any way on the process of investigation.
9. TEP is an information which is given in confidence to the IT officials and hence would fall under the said exemption clause.
10. In view of above, the decision of CPIO/AA is upheld and the appeal is disposed of.


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Yellen, who stepped down from the Federal Reserve in 2018, is a longtime Washington, D.C. insider, having served as chair of the White House council of economic advisers under former President Bill Clinton. If confirmed by the Senate, Yellen will be the first woman to helm the treasury department.
News of Biden's decision to appoint Yellen, which has yet to be confirmed by the former vice president's official transition team, comes as Congress and the Trump administration have been unable to negotiate another round of economic relief for individuals and businesses impacted by the novel coronavirus pandemic.
Although talks have intensified in recent weeks, Democrats, lead by House Speaker Nancy Pelosi (D-CA) and Senate Minority Leader Chuck Schumer (D-NY), are holding out for an expensive stimulus package that runs upwards of $2.2 trillion. The Trump administration, along with Senate Republicans, has proposed a smaller and targeted relief package, amounting to only $500 billion.
The gridlock appears unlikely to break at the moment, even though several coronavirus relief programs enacted earlier this year are set to expire in December.
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Biden, for his part, has stood behind Democrats in their calls for a broader relief program. The former vice president's choice of Yellen as treasury secretary, over more progressive figures like Sen. Elizabeth Warren (D-MA), signals that his administration will attempt to work with the congressional GOP upon taking office.
One particular area where Biden and Yellen could find common ground with Republicans, who appear poised to retain control of the Senate, will be on the deficit and national debt. The issue has particular resonance for Biden, who attempted to broker deals on the topic not only during the Obama administration but also as a senator in the 1970s and 1980s.
Yellen, herself, has spoken in recent months about the need to rein in the federal debt, arguing in February of this year that the United States' current economic path was "completely unsustainable."
http://feedproxy.google.com/~r/breitbart/~3/hAEv9PjLvYI/
What if Trump actually did it?
Inside Vanessa Hudgens' Date Night With MLB Player Cole Tucker
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Dr Jamal K. Mansour (BSc (Hons), BA, MA, PhD, CPsychol, FHEA) is a Senior Lecturer in the Psychology and Sociology Division. She is also a full member of the Centre for Applied Social Science and the Memory Research Group. For information about her research see the Mansour Lab web page.
I joined Queen Margaret University in 2013 after three years as an Assistant Professor at Simon Fraser University (Burnaby, Canada) in their Forensic Psychology area. I completed my MA (Social psychology) and PhD (Brain, Behavior, and Cognitive Science) at Queen's University in Kingston, Canada. My research concerns memory and decision making about faces, particularly with respect to eyewitness identification. I teach modules at all levels of the undergraduate degree on topics concerning memory, social influence, and experimental forensic psychology. I also supervise undergraduate and doctoral students as well as volunteer research assistants in areas relevant to my research.
The internal cognitive process involved in lineup decisions. For example, how do a witness' thoughts and beliefs about their memory for a perpetrator and their role as an eyewitness influence their lineup decision?
The influence of social and cognitive factors on lineup decisions. For example, what should police officers do when preparing a lineup for a suspect who has a tattoo? How can we ensure a lineup is fair to both the suspect and the witness? How does witnessing a perpetrator wearing a disguise affect how willing an eyewitness is to choose someone from a photo lineup?
Research Methods: Quantitative approaches, including experiments, surveys, think alouds, eye tracking.
I also supervise postgraduate students and students interested in gaining research experience as volunteer research assistants.


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Do you ever get a feeling that you're out of sync with the story line of the movies and series you see on television?
Do they glorify people and values you would criticize? Conversely, do they ridicule figures and institutions you hold in respect?
If so, you are not alone, and your impressions are justified in a recent study of creators of TV entertainment.
Three respected political scientists interviewed 104 of Hollywood's influential television writers, producers and executives as part of a larger study of elite groups.
Their finding, published in "Public Opinion," an organ of a Washington think tank called the American Enterprise Institute, was that the "value orientation" outlook of the cream of television's creative community "is fundamentally different from that of the general public."
This may come as no surprise, but documentation is impressive.
The authors, S. Robert Lichter, his wife, Linda S. Lichter, and Stanley Rothan, conclude "the television elites believe they have a role to play in reforming American society.
"Two out of three believe that TV entertainment should be a major force for social reform."
The researchers, now in the process of analyzing 40,000 tapes from old TV shows, report: "On such issues as abortion, homosexual rights and extramarital sex, (views of the TV elite) diverge sharply from traditional values.
"Ninety-seven percent believe that a woman has the right to decide for herself whether to have an abortion.
"Four out of five do not regard homosexual relations as wrong. Only five percent feel strongly that homosexuality is wrong.
"An even greater proportion, 86 percent, support the rights of homosexuals to teach in public schools.
"A majority of 51 percent refuse to condemn adultery as wrong ... only 17 percent strongly believe that extramarital affairs are wrong."
Very few have roots in middle America, the study shows. They were raised in big cities on both coasts; only one in five is from small-town America.
Ninety-three percent had a religious upbringing, 59 percent in the Jewish faith, 25 percent Protestant and 12 percent Catholic.
However, most of them now eschew religious affiliation. Only 7 percent ever attend services.
Seventy-five percent of the people who write and produce television entertainment consider themselves liberals and regularly vote Democratic.
This contrasts with a 1982 poll of the general public in which 27 percent classified themselves as liberal, 32 percent conservative and the remainder as moderates.
The TV elite's self-descriptions are reflected in their political behavior: In the past four elections, Democrats outpolled Republicans by margins that never dropped below three to one.
In 1980, former movie actor Ronald Reagan received 20 percent of the vote from the prime movers of his old industry.
The crucial question is whether their perspective influences their artistic output, and there are strong indications it does.
The Lichters found the elite portray businessmen as second only to professional criminals as the most frequent lawbreakers in their movies and television shows.
They make lawbreakers middle- or upper-class white males over 30.
Thirty-six percent of the villains are gangsters, 24 percent businessmen, 13 percent police, 8 percent professional people, 5 percent blue collar and 14 percent are others.
"In the struggle between good and evil on TV, businessmen cast their lot with the bad guys. Most were shown ... as criminals, fools or malevolent or greedy creatures," the researchers found.
More than 35 series were analyzed, including "Hart to Hart," "Vegas," "Magnum, P.I." "Dukes of Hazzard," "Quincy" and "Nero Wolfe."
The "Hill Street Blues" series is an exception that proves the rule, Lichter said. Cops mostly are good guys and petty criminals are not ignored.
And so influential is the weekly NBC drama about a police station a federal prosecutor told Lichter he never goes before a jury on Friday without watching the program on Thursday.
The jury almost certainly will have watched it, too, and they'll judge the prosecutor and his case by what they saw on TV the night before. BIOG: NAME:


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Watch What Happens When American Teens React To The Bravest Teen In The World: Malala
Who says teenagers can't change the world?
Erica Williams Simon
Malala Yousafzai has inspired people all over the world with her activism and advocacy for girls, education, human rights, and peace. But as the youngest Nobel Peace Prize winner ever, there's something special about the impact her story has on teens her own age.
When U.S. teens watched a news report of her being shot in the head by a gunman on a school bus in 2012, their reactions were, not surprisingly, pretty emotional.
But they were amazed at her courage in the face of discrimination, violence, and hate after her recovery.
They couldn't believe that she boldly took her place on the world's stage at the age of 14 years old (younger than some of them!), taking a stand for the rights of every child to get an education and live free from violence and oppression.
They even appreciated that she has spoken out about her religion and not allowed popular opinion, the media, or propaganda to override her truth.
And then, inspiration hit! They thought of their own lives and had some pretty deep things to say about the issues that are important to them and what stops them — and many of their peers — from taking a stand. They cover:
2. Terrorism
3. The media
4. Religious freedom
and a whole bunch of other issues that should restore your faith in young people. They really are pretty smart.
Their obstacles pale in comparison to hers, and yet, at such a young age, Malala has reminded them of what is possible when you speak truth to power and fight for what you believe in. Basically, she's their new hero.
Take a look at the video below to see Malala's story and even more terrific reactions to it.
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The Boucher Nude is a 1957 painting by Australian artist John Brack. The painting is a nude, depicting a woman lying on a sofa. Sasha Grishin, the William Dobell Professor of Art History at the Australian National University claimed that "The Boucher Nude can be justly regarded as one of the great masterpieces in Australian art."

The painting is one of a set of nine oil paintingsBrack's first paintings of the nudefirst displayed in Melbourne in 1957. The series "subsequently become iconic in Australian art" with many ending up in public collections including Nude in an armchair (1957) purchased by the National Gallery of Victoria and Nude with two chairs (1957) acquired by the Art Gallery of New South Wales, both directly from this initial exhibition.

With what has been described as his "characteristic irony", Brack painted his thin dark-haired modelthe only one to respond to his advertisementin "the pose of the more voluptuous Mademoiselle O'Murphy, in François Boucher's L'Odalisque (c.1745)""

In 2008, the painting was sold for AUD1,500,000.

References

Paintings by John Brack
1957 paintings
Nude art
Paintings in Australia


For photography, perhaps more than anything thing else I'm involved in, having a group of people who can give you solid feedback when you ask for it, applaud when you've done well, and give you a kick in the pants from time to time is absolutely critical. These need not be accomplished photographers themselves but people who are going to give you a relatively unbiased opinion, who want to help you succeed and will hold you accountable. To those people in my life thank you!
This entry was posted in Photo of the Week and tagged Coast, Glacial Erratics, New England, Portfolio, Rocks, Sand Sea Sky by nixonphoto. Bookmark the permalink.


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Wichita State University to honor Martin Luther King Jr.
Jan. 7, 2020 -- Wichita State University will celebrate the life and legacy of Dr. Martin Luther King Jr. with a series of events on campus and throughout the city of Wichita.
Alumnus Brenton D. Myers makes $1.25 million gift to College of Engineering
Dec. 9, 2019 -- A $1.25 million gift from the estate of Wichita State University alumnus Brenton D. Myers will support the WSU College of Engineering, where Myers earned the degree that helped him build a lifelong career in engineering and airport planning.
Meet a Shocker: Nayeli Cano, health management and health science grad
Dec. 4, 2019 -- Nayeli Cano is passionate about helping people and wants to work with underrepresented communities to provide equal access to health care for those in need.


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New drug can improve fertility in women with reproductive health problems
A drug that acts via the natural 'kisspeptin' hormone system in the body has the potential to treat reproductive health problems in women, according to a new study.
Twenty-four women were injected with a drug called MVT-602 which targets the kisspeptin system to stimulate reproductive hormones that affect fertility, sexual development and menstruation. The naturally occurring form of kisspeptin called kisspeptin-54 (KP54) has been researched for a number of years to treat reproductive disorders, but in the new study, MVT-602 induced more potent signalling of the kisspeptin system over a longer period of time than KP54.
The researchers behind the study suggest that MVT-602 may be used to effectively treat a range of reproductive conditions that affect fertility such aspolycystic ovary syndrome(PCOS)-a common condition that affects how a woman's ovaries work andhypothalamic amenorrhea (HA) – a condition where a woman's periods stop.
The researchers suggest that because of MVT-602's much longer duration of action, it can be given less frequently than the naturally occurring form of kisspeptin, whilst still being able to maintain the degree of stimulation of reproductive hormone levels required to restore reproductive health.
The study, published in the Journal of Clinical Investigation, is led by researchers at Imperial College London and clinicians at Imperial College Healthcare NHS Trust.
Professor Waljit Dhillo, lead author, NIHR Research Professor in Endocrinology and Metabolism at Imperial College London and Consultant in Endocrinology at Imperial College Healthcare NHS Trust said: "Reproductive health issues are common for women around the world.Infertility as a result of these conditions can cause a lot of distress.Although we have made great strides in developing treatments for infertility and other reproductive disorders there is a need to find more effective treatments.Our previous work showed that kisspeptin can be used to stimulate ovulation in women undergoingin vitrofertilisation (IVF) treatment, but there are some limitations on using the naturally occurring kisspeptin hormone as its effectiveness wares off after a few hours.This study suggests that MVT-602 can stimulate kisspeptin over a longer period of time with no side effects, which means we could potentially use it to treat a wider range of reproductive disorders.This is an early stage study and more research needs to be carried out to fully determine the effects of MVT-602 on more patients."
Dr Ali Abbara, NIHR Clinician Scientist at Imperial College London and Consultant in Endocrinology at Imperial College Healthcare NHS Trust,who co-led the work added: "This is the first study to show that a single dose of MVT-602 can induce a longer duration of hormonal stimulation in women than naturally occurring kisspeptin. Therefore, it reveals exciting potential to treat a range of reproductive health conditions using MVT-602 and offer women improved treatment options. However, further research is needed to fully characterise its effects in specific disorders that affect reproductive health."
One in ten women in the UK are diagnosed with PCOS or HA.Current treatments for these conditions include dietary changes, medicines that treat infertility by restoring ovulation, and IVF treatment for those who still are unable to conceive.However, women with PCOS who undergo IVF treatment are at increased risk of 'ovarian hyperstimulation syndrome' (OHSS) – a potentially life-threatening side-effect of IVF treatment.
Kisspeptin is a naturally occurring hormone thatcontrols the levels of other reproductive hormonesin the body and plays an important role in fertility, reproductive health and the regulation of normal menstrual cycles. Previous studies have shown that kisspeptin can be used to safely stimulate reproductive hormones in women undergoing IVF treatment without causing OHSS. The research team wanted to see whether MVT-602 could target the kisspeptin pathway and produce a longer hormonal release than the naturally occurring form of kisspeptin – which is important for using kisspeptin to treat reproductive disorders.
Researchers carried out a trial at Hammersmith Hospital, part of Imperial College Healthcare NHS Trust, on 24 women aged 18-35 from 2017-2019.Twelve of the women were healthy volunteers and 12 of the women had either PCOS or HA.All of the women were given MVT-602.In addition,all of the healthy volunteers were given an injection of the naturally occurring kisspeptin (KP54) and saline placebo for comparison.The researchers then compared thewomen's reproductive hormone levels after receiving MVT-602 to naturally occurring kisspeptin (KP54).They also compared the reproductive hormone levels after MVT-602 between healthy women, women with HA and those with PCOS.
They found that all of the women given MVT-602 had a longer duration of raised reproductive hormones, specifically luteinising hormone (LH) and follicle stimulating hormone (FSH) levels, than when they received native kisspeptin (KP54).LH levels peaked at 21-22 hours after MVT-602 and remained elevated for 48 hours.This is in comparison to natural kisspeptin (KP54) whereby LH levels peaked at 4.7 hours after administration and remained elevated for 12-14 hours.Therefore, the duration of LH rise was extended by approximately four times using MVT-602.
LH increases following MVT-602 were similar in PCOS and healthy women, but rose more quickly in women in HA.Theoretically, this could be because women with HA have more kisspeptin receptors in the hypothalamus of the brain where kisspeptin acts as a result of their condition.
Source: Imperial College London
Tags:	fertility, imperial college london, kisspeptin, reproductive health
Microfluidic chip predicts risk of preterm birth
Artificial 'womb' unlocks secrets of early embryo development
Certain factors during infancy may affect bone health in adulthood
Better conditions needed for midwives in NHS
Pregnancy and reproductive history may impact dementia risk
Women with a fear of childbirth endure a longer labour, finds new research
Tommy's launches its PregnancyHub to support families throughout their pregnancy journey
Special occasion drinking during pregnancy may cause harm


Please join us for a lecture on what big data can tell us about the publishing industry and literary styles with Laura McGrath, the Associate Director of the Stanford University Literary Lab. Professor McGrath will also host an open seminar on the same date, "Quantifying without Computers" from 11-12:30.
More than bestseller lists of academic consecration via syllabi, "comps" (short for "comparative titles") represent the most significant metric of literary value in contemporary publishing. Comps are identified by editors in the acquisition process to predict a book's performance on the market and are often the deciding factor in a new acquisition. In this talk, McGrath will use large-scale computational methods to analyze comp title data obtained from publishers' quarterly catalogues between 2013-2019. She shows how comps produce and replicate "corporate style," not only limiting what--and who--is published, but defining literary style in the contemporary.


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Posted on September 21, 2017 March 19, 2018 by Matt Williams
New Study Says a Fast Radio Burst Happens Every Second in the Universe
When astronomers first noted the detection of a Fast Radio Burst (FRB) in 2007 (aka. the Lorimer Burst), they were both astounded and intrigued. This high-energy burst of radio pulses, which lasted only a few milliseconds, appeared to be coming from outside of our galaxy. Since that time, astronomers have found evidence of many FRBs in previously-recorded data, and are still speculating as to what causes them.
Thanks to subsequent discoveries and research, astronomers now know that FRBs are far more common than previously thought. In fact, according to a new study by a team of researchers from the Harvard-Smithsonian Center for Astrophysics (CfA), FRBs may occur once every second within the observable Universe. If true, FRBs could be a powerful tool for researching the origins and evolution of the cosmos.
The study, titled "A Fast Radio Burst Occurs Every Second throughout the Observable Universe", recently appeared in The Astrophysical Journal Letters. The study was led by Anastasia Fialkov, a postdoc researcher and Fellow at the CfA's Institute for Theory and Computation (ITC). She was joined by Professor Abraham Loeb, the director of the ITC and the Frank B. Baird, Jr. Professor of Science at Harvard.
As noted, FRBs have remained something of a mystery since they were first discovered. Not only do their causes remain unknown, but much about their true nature is still not understood. As Dr. Fialkov told Universe Today via email:
"FRBs (or fast radio bursts) are astrophysical signals of an undetermined nature. The observed bursts are short (or millisecond duration), bright pulses in the radio part of the electromagnetic spectrum (at GHz frequencies). Only 24 bursts have been observed so far and we still do not know for sure which physical processes trigger them. The most plausible explanation is that they are launched by rotating magnetized neutron stars. However, this theory is to be confirmed."
For the sake of their study, Fialkov and Loeb relied on observations made by multiple telescopes of the repeating fast radio burst known as FRB 121102. This FRB was first observed in 2012 by researchers using the Arecibo radio telescope in Puerto Rico, and has since been confirmed to be coming from a galaxy located 3 billion light years away in the direction of the Auriga constellation.
Since it was discovered, additional bursts have been detected coming from its location, making FRB 121102 the only known example of a repeating FRB. This repetitive nature has also allowed astronomers to conduct more detailed studies of it than any other FRB. As Prof. Loeb told Universe Today via email, these and other reasons made it an ideal target for their study:
"FRB 121102 is the only FRB for which a host galaxy and a distance were identified. It is also the only repeating FRB source from which we detected hundreds of FRBs by now. The radio spectrum of its FRBs is centered on a characteristic frequency and not covering a very broad band. This has important implications for the detectability of such FRBs, because in order to find them the radio observatory needs to be tuned to their frequency."
Image of the sky where the radio burst FRB 121102 was found, in the constellation Auriga. You can see its location with a green circle. At left is supernova remnant S147 and at right, a star formation area called IC 410. Credit: Rogelio Bernal Andreo (DeepSkyColors.com)
Based on what is known about FRB 121102, Fialkov and Loeb conducted a series of calculations that assumed that it's behavior was representative of all FRBs. They then projected how many FRBs would exist across the entire sky and determined that within the observable Universe, a FRB would likely be taking place once every second. As Dr. Fialkov explained:
"Assuming that FRBs are produced by galaxies of a particular type (e.g., similar to FRB 121102) we can calculate how many FRBs have to be produced by each galaxy to explain the existing observations (i.e., 2000 per sky per day). With this number in mind we can infer the production rate for the entire population of galaxies. This calculation shows that an FRB occurs every second when accounting for all the faint events."
While the exact nature and origins of FRBs are still unknown – suggestions include rotating neutron stars and even alien intelligence! – Fialkov and Loeb indicate that they could be used to study the structure and evolution of the Universe. If indeed they occur with such regular frequency throughout the cosmos, then more distant sources could act as probes which astronomers would then rely on to plumb the depths of space.
For instance, over vast cosmic distances, there is a significant amount of intervening material that makes it difficult for astronomers to study the Cosmic Microwave Background (CMB) – the leftover radiation from the Big Bang. Studies of this intervening material could lead to a new estimates of just how dense space is – i.e. how much of it is composed of ordinary matter, dark matter, and dark energy – and how rapidly it is expanding.
Gemini composite image of the field around FRB 121102, the only repeating FRB discovered so far. Credit: Gemini Observatory/AURA/NSF/NRC
And as Prof. Loeb indicated, FRBs could also be used to explore enduring cosmlogical questions, like how the "Dark Age" of the Universe ended:
"FRBs can be used to measure the column of free electrons towards their source. This can be used to measure the density of ordinary matter between galaxies in the present-day universe. In addition, FRBs at early cosmic times can be used to find out when the ultraviolet light from the first stars broke up the primordial atoms of hydrogen left over from the Big Bang into their constituent electrons and protons."
The "Dark Age", which occurred between 380,000 and 150 million years after the Big Bang, was characterized by a "fog" of hydrogen atoms interacting with photons. As a result of this, the radiation of this period is undetectable by our current instruments. At present, scientists are still attempting to resolve how the Universe made the transition between these "Dark Ages" and subsequent epochs when the Universe was filled with light.
This period of "reionization", which took place 150 million to 1 billion years after the Big Bang, was when the first stars and quasars formed. It is generally believed that UV light from the first stars in the Universe traveled outwards to ionize the hydrogen gas (thus clearing the fog). A recent study also suggested that black holes that existed in the early Universe created the necessary "winds" that allowed this ionizing radiation to escape.
To this end, FRBs could be used to probe into this early period of the Universe and determine what broke down this "fog" and allowed light to escape. Studying very distant FRBs could allow scientists to study where, when and how this process of "reionization" occurred. Looking ahead, Fialkov and Loeb explained how future radio telescopes will be able to discover many FRBs.
The planned Square Kilometer Array will be the world's largest radio telescope when it begins operations in 2018. Credit: SKA
"Future radio observatories, like the Square Kilometer Array, will be sensitive enough to detect FRBs from the first generation of galaxies at the edge of the observable universe," said Prof. Loeb. "Our work provides the first estimate of the number and properties of the first flashes of radio waves that lit up in the infant universe."
And then there's the Canadian Hydrogen Intensity Mapping Experiment (CHIME) at the at the Dominion Radio Astrophysical Observatory in British Columbia, which recently began operating. These and other instruments will serve as powerful tools for detecting FRBs, which in turn could be used to view previously unseen regions of time and space, and unlock some of the deepest cosmological mysteries.
"[W]e find that a next generation telescope (with a much better sensitivity than the existing ones) is expected to see many more FRBs than what is observed today," said Dr. Fialkov. "This would allow to characterize the population of FRBs and identify their origin. Understanding the nature of FRBs will be a major breakthrough. Once the properties of these sources are known, FRBs can be used as cosmic beacons to explore the Universe. One application is to study the history of reionization (cosmic phase transition when the inter-galactic gas was ionized by stars)."
It is an inspired thought, using natural cosmic phenomena as research tools. In that respect, using FRBs to probe the most distant objects in space (and as far back in time as we can) is kind of like using quasars as navigational beacons. In the end, advancing our knowledge of the Universe allows us to explore more of it.
Further Reading: CfA, Astrophysical Journal Letters
CategoriesAstronomy, Cosmology, Radio Astronomy TagsCfA, Dark Ages, fast radio bursts (FRBs), Featured, FRB, Harvard Smithsonian Center for Astrophysics, Neutron Stars, Radio Astronomy, Reionization of the Universe
2 Replies to "New Study Says a Fast Radio Burst Happens Every Second in the Universe"
stuartajc says:
" and are still speculated as to what causes them"
Really? I love UT but please …
Starreeyed says:
"The most plausible explanation is that they are launched by rotating magnetized neutron stars."
I have a problem with this possible explanation for FRBs. EM radiation is emitted by neutron stars from their poles. If one of their poles is pointed towards the Earth for a split-second as the star rotates, then we can detect that blip of radiation. Hence, we see a blip every time the star makes one rotation. We do not see a single blip, then nothing. By this reasoning, I conclude there must be some other explanation for FRBs.
If an FRB is launched by some mechanism from a random point on the surface of a magnetar, and the time duration for the phenomenon is less than the time for two rotations of the star, then we would see only a single blip, but only if that random point is in direct alignment with the Earth.
Now we are confronted with the conundrum of FRB 121102, the only known repeating FRB, which brings me back to radiation from the star's pole. Very perplexing. The alien communication explanation I would reject out of hand because all but one FRB does not repeat. You do not communicate by broadcasting a single word.
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Ask the Expert: How can I deploy ThingWorx Docker images on Kubernetes?
Ready to deploy ThingWorx containers on Kubernetes using Helm?
Let's get started using the steps below from Luis, one of our awesome software developers.
Before you dive too far in, please note that the following instructions assume you have downloaded the Docker scripts from our downloads portal and followed the instructions to build and publish the ThingWorx Docker images to your own Docker registry; they also assume that you have a working Kubernetes cluster with sufficient resources available.
These steps are intended to be used as a deployment manual and will not provide in-depth information about Kubernetes or the Helm package manager.
In this example, we'll use the ThingWorx platform with PostgreSQL as a persistence provider.
This will show you the default configuration (values.yaml) and instructions (README.md) provided within the package. In the next steps, you'll see how to override some of these values to make the deployment fit your environment.
Let's create your custom values file. Use your favorite text editor and create a new file that looks like the following example. Please note the comments and make the necessary adjustments.
Note: The default values.yaml file included in the chart contains default usernames and passwords that must be changed before using this chart for production purposes.
To change them also include a block like the following in your myValues.yaml.
Save this file as myValues.yaml.
If you have never used Helm with your cluster before, you should run the following command. This will install/upgrade the Helm server-side component (Tiller) on your Kubernetes cluster.
Now, to deploy ThingWorx, run the following command. This will deploy ThingWorx into your current kube config namespace. If you want to deploy into a specific namespace use the --namespace or -n flag.
Wait a few seconds and you should have ThingWorx deployed onto your Kubernetes cluster.
Leave the terminal open and point your browser to http://localhost:8080/Thingworx.
Here's a quick video explaining the deployment of ThingWorx Docker images on Minikube.


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Nathan Oliveira, né le  à Oakland (Californie) et mort le  à Palo Alto (Californie), est un peintre, graveur et sculpteur américain.

Depuis la fin des années 1950, il a exposé dans près d'une centaine d'expositions individuelles et autant d'expositions de groupe, dans d'importants musées et galeries du monde entier, notamment pendant les expositions annuelles du Whitney Museum of American Art. De la fin des années 1950 et début des années 1960, à ce jour, il exposé un travail en constante évolution.

Il enseigne la peinture durant plusieurs décennies en Californie, d'abord au début des années 1950 à Oakland, puis à l'université Stanford. Nathan Oliveira est considéré comme l'un des pionniers du retour au figuratif dans la peinture américaine, mouvement qui a pris naissance autour de la baie de Californie dans les années 1950. Avec ses collègues et amis, Oliviera va répondre à l'expressionnisme abstrait qui domine l'art à cette époque, par un retour à l'imagerie traditionnelle.

Carrière
Oliveira a fréquenté les écoles d'arts d'Oakland, d'abord au Mills College, où il a assisté aux cours donnés par Max Beckmann, et plus tard au California College of the Arts, où il a obtenu un BFA en 1951 et un MFA en 1952. Professionnel, il enseigne l'art dans plusieurs écoles, et notamment au California College of the Arts et l'université Stanford.

 1952-53 California College of Arts and Crafts, Oakland,
 1955-56 California College of Arts and Crafts, Oakland,
 1964-96 Professeur d'Arts, université Stanford

Récompenses
 2000 : décoré commandeur de l'ordre de l'Infant Dom Henrique par le président du Portugal et le gouvernement portugais.
 1997 : début de la publication d'une importante monographie sur sa vie et son œuvre par les Presses de l'université de Berkeley, dont l'auteur est Susan Landauer. Ce travail débute en 1998.
 1996 : déclaré docteur honoris causa ès beaux-arts, au San Francisco Art Institute.
 Honoré par la California Society of Printmakers pour ses réalisations artistiques remarquables.
 1994 : élu membre de l'Académie américaine des arts et des sciences de Cambridge.
 Élu membre de l'American Academy of Arts and Letters de New York.
 1992 distingué professeur "émérite" d'arts à la Chaire d'Ann O'Day Maples à l'université Stanford
 1988 : désigné professeur d'arts à la Chaire d'Ann O'Day Maples à l'université Stanford
 1985 Académicien, ès arts graphiques, de la National Academy of Design de New York.
 1984 Prix de l'Adademy Institute, ès Art, à l'American Academy and Institute of Arts and Letters de New York.
 1982 : élu membre associé de la National Academy of Design de New York.
 1974 Obtient la bourse du National Endowment for the Arts.
 1968 : déclaré docteur honoris causa ès beaux-arts du California College of Arts and Crafts d'Oakland.
 1964 : obtient à nouveau la bourse "Tamarind" pour son travail en lithographie. Los Angeles.
 1963 : prix spécial en art contemporain d'Amérique et d'Espagne à Madrid (Espagne).
 Obtient une première fois la bourse "Tamarind" pour son travail en lithographie. Los Angeles.
 1959 : médaillé de bronze (médaille "Norman Wait Harris") à l'Art Institute of Chicago.
 1958 : obtient la bourse "John Simon Guggenheim".
 1957 : obtient la bourse de la Louis Comfort Tiffany Foundation.

Association artistique
Dans les années 1950 et 1960, il est membre de l'École de San Francisco, un mouvement artistique localisé autour de la baie du même nom, et qui pronait un retour du figuratif par réaction à l'omniprésence de l'art abstrait dans l'art contemporain. Ses collègues dans ce groupe sont Richard Diebenkorn, David Park, Elmer Bischoff, et plus tard Joan Brown et Manuel Neri. Oliveira est aussi connu pour son travail exceptionnel de graveur, et pour ses œuvres uniques dans le monde de la monotypie. Aujourd'hui, il expose ses tableaux dans les musées et galeries du monde entier.

Travaux récents
À partir des années 2000, Oliveira travaille à une série de toiles librement inspirées du poème de Gerard Manley Hopkins intitulé "Le Windhover". Cette œuvre devrait trouver sa place dans l'avenir dans le centre contemplatif de l'université Stanford.

Notes et références

Annexes

Articles connexes
 École de San Francisco

Liens externes

  Nathan Oliveira sur le site de la Galerie John Berggruen.

Naissance en décembre 1928
Naissance à Oakland (Californie)
Étudiant du Mills College
École de San Francisco
Peintre américain du XXe siècle
Graveur américain du XXe siècle
Lithographe américain du XXe siècle
Sculpteur américain du XXe siècle
Artiste contemporain américain
Décès en novembre 2010
Décès à 81 ans
Boursier Guggenheim


text:
Obama Sides With State Government Unions Against Cuts
By Chris Stirewalt, | Fox News
Obama Takes Sides in Wisconsin Labor Battle
"Some of what I've heard coming out of Wisconsin, where you're just making it harder for public employees to collectively bargain, generally seems like more of an assault on unions. I think it's very important for us to understand that public employees, they're our neighbors, they're our friends."
-- President Obama in an interview with Milwaukee's WTMJ
Wisconsin has been wracked with protests and work stoppages as government employees fight a fiscal austerity proposal from new Republican Gov. Scott Walker. Now, President Obama is weighing in against Walker and sticking up for government workers.
Walker's plan would force state workers to cover half of their pension contributions and 13 percent of their own health insurance costs. Walker would strip government unions of the power to collectively bargain for higher wages unless approved by a public vote. The plan would also end compulsory dues payments for state workers.
Walker has said that if lawmakers don't agree to his plan, he will be forced to lay off 6,000 of the state's 170,000 workers.
The reaction has been intense in Madison, which is one of the great strongholds of organized labor and liberalism in the nation. Ten thousand labor activists jammed the state capitol, chanting and screaming at lawmakers. Schools have been shut down as unionized teachers conducted an organized "sick out" and brought their students to join the march against Walker.
New Jersey's Chris Christie was the first and most famous part of the trend of governors getting tough with public workers, but the class of 2010 has quickly followed suit. New York Democrat Andrew Cuomo has been battling government workers over pay and benefits. In California, Democrat Jerry Brown is also asking for state workers to take pay cuts and has frozen hiring.
The cause for the nationwide crackdown is massive budget shortfalls threatening to crush state governments as they prepare spending plans for the next year. The collective shortfall for the coming fiscal year has been estimated at more than $120 billion.
Obama's home state of Illinois has the worst budget problem in the nation, driven largely by massively under-funded pension plans for state workers. But Democratic Gov. Pat Quinn is bucking the trend of austerity.
Quinn, wearing an African Kente cloth in honor of black history month, laid out a $52.7 billion budget proposal Wednesday that would increase spending by $1.7 billion and borrow $8.75 billion with bonds backed by new taxes approved last month that double rates.
In Wisconsin, which took a sharp turn to the right in the 2010 elections, Walker has vowed to close his state's $3.7 billion shortfall for the next two years by cutting costs and not raising taxes.
Obama also blasted Walker for rejecting a project to build a high-speed rail line as "short sighted" in his interview with the NBC affiliate in Milwaukee. But Obama was strongest in his defense of the protesting labor activists. Obama said that while it was necessary for state workers to perhaps make some "adjustments" he accused Walker of an "assault" on unions and praised government workers for their value to society.
The president echoes an attack from congressional Democrats who claim that federal budget cuts proposed by House Republicans would jeopardize federal jobs.
Government worker unions are crucial to Democratic hopes for 2012. Walker's proposal is especially upsetting to the president's party because it would no longer have the state government skim union dues from state paychecks to pass on to labor groups. Instead dues, which fund Democratic campaigns, would be paid on a voluntary basis.
Public union membership now outnumbers that of private unions and continues to grow.
As the spending battle plays out in Washington and across the country, Democrats will work hard to protect government unions from cuts.
Bahrain Crackdown Complicates Administration's Position
"We thought that if we were there they wouldn't do this. We were wrong."
-- Bahrainian protester "Hussein" talking to the Wall Street Journal about a massive police raid that left at least two dead
The kingdom of Bahrain was an ideal pick for the headquarters of the U.S. Fifth Fleet almost 20 years ago. The petro-rich island nation of 1.2 million off the coast of Saudi Arabia was strategically located, peaceful and ruled by a moderate, Sunni royal family well disposed to American interests.
Now, the nation's majority Shia population, with the support of their fellow Shia in Iran, is in revolt. The same uprisings that have wracked a series of U.S.-friendly governments in the region have taken hold in the capital of Manama.
On Thursday, though, the royal government did what other U.S. allies have not and sent armed police on a massive raid against protesters who were imitating their Egyptian counterparts in occupying the city's central square.
At least two are dead and many more are injured in the wake of the raid by hundreds of police officers firing rubber bullets, tear gas and buckshot.
The tricky bit for the U.S. is this: The standard position of the Obama administration on the ongoing Middle East uprising is to call on all parties to be peaceful. But having the Iranian-backed Shia take over a strategic spot like Bahrain could only be bad news for the U.S.
Having now roused himself to the idea of being on "the right side of history" in the region, can Obama now watch U.S. allies continue to topple? Or, with huge strategic interests in the region, can he tacitly condone violence against protesters?
The administration is touting today a special report that the president commissioned in August to look at the likelihood of Middle East uprisings and ways the U.S. government could use unrest to facilitate a transition to democracy. But if the administration had even an inkling that so many stalwart American friends would be under attack, there were no apparent preparations made.
U.S. Agrees to Join U.N. Condemnation of Israel
"…the Security Council… expresses its strong opposition to any unilateral actions by any party, which cannot prejudge the outcome of negotiations and will not be recognized by the international community, and reaffirms, that it does not accept the legitimacy of continued Israeli settlement activity, which is a serious obstacle to the peace process."
-- Proposed resolution at the U.N. Security Council condemning Israeli settlements obtained by Foreign Policy magazine
The U.S. ambassador to the United Nations has proposed for the first time ever to join a coalition of Arab and European nations in condemning Israel.
American Ambassador Susan Rice is casting the move as an effort to prevent a more harshly worded rebuke over Israeli settlements in sections claimed by Palestinians. But, the compromise measure backed by Rice would still be a sharp departure from decades of U.S. policy on Israel.
The U.S., like the other four permanent members of the Security Council, could veto any resolution against Israel, as has been the practice in the past.
But Rice, along with the rest of the Obama administration, is looking to force Israel to the negotiating table to discuss a peace treaty with the Palestinians. Backing the more tempered rebuke, which also finds some fault with the Palestinians, is seen as a way to pressure Israel to reengage in the stalled talks.
But this is a strange time to be doing anything with Israel. Egypt, the bulwark of peace between Jews and Arabs, is in turmoil. Iran's regime seems to be radicalizing again and Islamists are on the march throughout the region. Rather than accepting U.S. pressure for more concessions to the Palestinians, the Israelis are of more of a mind to assert themselves.
The vote at the Security Council is set for Friday.
Obama to Meet With Democratic Donors/Tech CEOs
"The more your phone knows about you, the better."
-- Google CEO Eric Schmidt at a Barcelona mobile technology conference defending his company's collection of personal data about its users
President Obama heads to San Francisco today to meet with corporate captains and Democratic donors Steve Jobs of Apple and Eric Schmidt of Google. Also in tow will be Obama's favorite business booster, General Electric CEO Jeffrey Immelt.
The forum for tech leaders, which also includes Mark Zuckerberg of Facebook, is the first time that Jobs has appeared publicly since he took a leave of absence from Apple because of health problems.
While the meeting is billed as being in support of the president's green energy spending plan, it is just the start of an Obama effort to enlist the help of the tech sector for his 2012 reelection bid.
It shouldn't be a heavy lift. The companies, particularly Google, have lots of issues pending with the Obama administration – Internet regulations, privacy rules, government contracts, etc. Plus, Jobs and Schmidt are both well known for their support for liberal causes.
But if Obama is going to raise the $1 billion he is trying to gather for his reelection bid, he will need the old guard to dig deep and the younger generation, like the so-far apolitical Zuckerberg, to get on the left side of the political ledger.
Pakistan Still Holding American Diplomat
"How can I issue any order when I do not have anything from the federal government regarding his diplomatic immunity?"
-- Chief Justice Ijaz Chaudhry of Pakistan's Punjab province ordering a three-week delay in the case of an American embassy worker held on murder charges
The Pakistani government won a three-week delay in a hearing on the status of a security contractor at the U.S. embassy there, leaving hanging an American demand that he be released immediately on diplomatic immunity.
The country's central government has limited sway in the Islamist-leaning province of Punjab, where the killing of two young Pakistani men by embassy worker Raymond Davis has created massive public outrage.
The U.S has demanded that Davis, a former Special Forces officer who claims he shot the men in self defense during a robbery attempt, be returned immediately or face serious diplomatic sanctions including the cancellation of a state visit for embattled President Ali Zardari next month.
The move today by a prosecutor from Zardari's government suggests that Zardari may lack the clout to order Davis' release but is working to try to gain concessions from local authorities.
If Zardari is in such a direly weakened situation as not to be able to answer the basic demand of his country's most important ally, his value as an ally in the war in neighboring Afghanistan would be in dubious condition.
Chris Stirewalt joined Fox News Channel (FNC) in July of 2010 and serves as politics editor based in Washington, D.C.


A physicochemical property-based desirability scoring scheme for fragment-based drug discovery was developed for class A aminergic GPCR targeted fragment libraries. Physicochemical property distributions of known aminergic GPCR-active fragments from the ChEMBL database were examined and used for a desirability function-based score. Property-distributions such as log D (at pH 7.4), PSA, pKa (strongest basic center), number of nitrogen atoms, number of oxygen atoms, and the number of rotatable bonds were combined into a desirability score (FrAGS). The validation of the scoring scheme was carried out using both public and proprietary experimental screening data. The scoring scheme is suitable for the design of aminergic GPCR targeted fragment libraries and might be useful for preprocessing fragments before structure based virtual or wet screening.


Oh my gosh are these little scones amazing. If you want to really impress your family during brunch, then you have to make these! I never made scones before, so I was a bit curious about how these would turn out. I promise you, these are so simple and so delicious that people will think you ran out to the best bakery in town to pick up a big batch!
What's even more impressive are the little flecks of vanilla bean scattered throughout the scones itself and in the glaze.
You can make these up to 3 days in advance and they will still taste super fresh!
Combine the flour, sugar, baking powder and salt in a large bowl. Cut the cold butter into small pieces and add to the flour mixture. Using a pastry blender or two knives, cut the butter into the flour until it resembles small crumbs.
Add the egg to the cream and vanilla mixture and whisk together. Then, add to the flour/butter mixture. Stir gently with a fork until it all comes together.
Cut the dough into 12 equal square pieces. Then, cut each square in half to make 2 triangles. (see the pictures below) Transfer to a parchment paper-lined baking tray. (I needed to use 2 trays) Bake for 18 minutes, removing just before the scones turn golden. Allow to cool on the trays for 15 minutes before removing to a cooling rack.
Once the scones are completely cooled, start making the glaze. Scrape the caviar out of the vanilla bean and stir into the milk. Set aside for about 15 minutes. Mix the sifted powdered sugar and salt with the vanilla milk. Whisk until completely smooth.
One at a time, carefully dunk the scones into the glaze (tops only!). Transfer to parchment paper or the cooling rack. Allow the glaze to set completely, about 1 hour. Scones will keep several days once they are glazed. Enjoy with a hot cup of coffee!!