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John C. Flinn, III
Suzanne Sternlicht
February 1st - 15th, 2261
The Illusion of Truth
Garibaldi resigns his position. Bester returns with the news that Earth Alliance plans to isolate and discredit Babylon 5.
Bruce Boxleitner as Captain John Sheridan
Claudia Christian as Commander Susan Ivanova
Andreas Katsulas as Ambassador G'Kar
Peter Jurasik as Ambassador Londo Mollari
Jason Carter as Marcus Cole
Special Guest Star Edit
Walter Koenig as Bester
Damian London as Minister Milo Virini
Victor Ludlin as Psi Corps Official
Robert Patteri as EA Pilot
Lauren Sanchez as News Anchor
Regular characters appearing in this episode are John Sheridan, Susan Ivanova, Michael Garibaldi, Delenn, Stephen Franklin, Zack Allan, Lyta Alexander, Londo Mollari and G'Kar.
On Babylon 5, the whole station is celebrating the end of the Second Shadow War. Starfuries are flying and setting off fireworks while inside the corridors are decorated and everyone dancing. John Sheridan and Delenn watch from a catwalk. Sheridan ponders what it cost, and what still lies ahead.
Meanwhile, at Psi Corps Headquarters, Alfred Bester is being informed that President Morgan Clark has commissioned a new program involving the Psi Corps, Earthforce, Nightwatch and Ministry of Peace. He can't reveal many details, but does say Clark has been rattled by something and wants Babylon 5 shut down for good.
Bester gets more details. Since Earthforce was repelled last year against B5, they can't risk another attack and alien government groups on Earth still support it. They need to discredit B5 instead.
On Centauri Prime, Milo Virini informs Londo Mollari his ship is ready for B5 and asks Mollari to stay awhile. Mollari feels it isn't safe for him at the moment. Mollari also informs Virini that he's been appointed Regent in the interim before a new Emperor can be chosen. Mollari leaves him to adjust.
In B5's Medlab, Stephen Franklin examines G'Kar's eye injury. He offers a prosthetic, though it won't be perfect. G'Kar is very pleased and leaves, but before confirming to Franklin that he did not accept the Narn Regime leadership.
Meanwhile, Michael Garibaldi is recalling his experience while he was abducted. He gets a message from an unknown source, a coded video of bright colored lights. He immediately ends the transmission, deletes it, and heads to Sheridan's office. There, the command staff has gathered. He stops Sheridan from the starting the meeting to resign as head of security immediately.
The others are shocked and try to talk him out of it, but he really just wants out. He feels he did his part and needs to make his own way, which is what the war was about.
In the customs area, Zack Allan is instructing his team when Mollari arrives. After a bit of banter, Allan processes him through. Then, Bester arrives, escorted by two security officers, and, interestingly, is happy to wait in the brig while the captain is notified of his presence. After he leaves, as if on cue, Allan gets a call to see the captain about Garibaldi. Allan decides to leave before anyone else comes. Indeed, as he does so, a few Elvis impersonators arrive.
G'Kar visits Garibaldi as he packs. He is very stern-looking as Garibaldi says he knows what G'Kar went through, now a bit worried since G'Kar would not have gone through it if he hadn't gone looking for him. G'Kar approaches slowly, prompting an apology from Garibaldi, but then very happily picks him up in joy. G'Kar doesn't take the apology, since his experience put him in the right place to make the deal with Mollari, and notes it was the universe that rewards a person. He also says Garibaldi was the only thing outside of his people he could care about, and he got so much in return. He thanks Garibaldi and leaves.
Allan is given Garibaldi's position as he notes that Garibaldi's been acting differently ever since his abduction. His first order is to get Lyta Alexander ready for a meeting with Bester. Just then, Sheridan is notified of an ISN transmission – informing the public of a travel ban to B5 for any Earth ship.
Allan meets with Alexander, who is now shopping for her recently bare apartment. He informs her of Bester's presence and Sheridan's request for her to help keep him in check. This prompts a brief outburst from her, since she is only called on when needed for something instead of for social calls. Allan admits her association with the Vorlons and the rumor that they changed her is part of it, which Alexander knew but never heard out loud. She agrees to come.
Mollari is haggling in the Zócalo when he sees G'Kar. After a tense moment, he decides to approach him. G'Kar declares he no longer considers Mollari part of his universe, now that Narn Homeworld is free, and prays it stays that way.
Bester starts his meeting by protesting Alexander's presence and demanding to arrest her. Sheridan declines and demands he continue. Bester relays the information he obtained, that Clark wants to discredit B5 knowing that Sheridan will come for him sooner or later. Phase 1 is a disinformation campaign. Phase 2 comes at a price – that they take Bester to Z'ha'dum to find technology that can help free his lover. As the group debate it, Bester tries to scan the others. Alexander detects him scanning her and stops him with her mind, forcefully. The others notice his head snap, but Bester shrugs it off. Sheridan gives Bester his word they'll get him there. Bester then describes Phase 2: the Sector 49 Earthforce base will keep patrols to prevent any ship from getting to B5, only to be destroyed by a secret Black Omega force that Clark will use to blame B5 for the incident.
Allan is picking up the emergency codes to lock down the station from Garibaldi. During, Garibaldi prompts Allan for his thoughts. When Allan says he thinks he's making a mistake, Garibaldi notes he's made a lot of mistakes, and people thought he was making a mistake to hire Allan. Allan appreciates it and Garibaldi hands him the codes.
On a White Star, Sheridan and Delenn spend a few moments together. Delenn notes Sheridan wants life to be very choatic and busy.
Meanwhile, the Earthforce Starfuries are engaged by the Black Omega force. The B5 Starfuries successfully prevent them from completing their mission. During, Bester tries to get Alexander to rejoin the Corps, now seeing she is more powerful than before and has an obligation to share it. She denies it.
When the group gets to Z'ha'dum, they find a mass exodus. Alexander confirms the planet seems dead, and Sheridan immediately orders them to turn around. Bester objects, but soon the planet breaks apart
Bester is led to the spot where they are keeping Sanderson. He talks to her, admitting that he sent the Black Omega force on their mission knowing he was setting a trap for them by using Sheridan, and lamenting that it was for nothing. He also notes that, despite the B5 staff laughing at him now, he has an ace in the hole that will hurt them. He admits he misses her, as she's the only one he can talk to.
Sheridan visits Alexander and notes that the timing of Z'ha'dum's destruction was convenient. He presents his evidence that she may be responsible, though doesn't know why. Alexander replies that, theoretically, it could have been additional Vorlon programming or simply revenge on Bester. Sheridan ends the conversation insisting that she always keep him in the loop or else he'll turn her over. After he leaves, Alexander can't calm down before Allan arrives with a pizza, offering to help her unpack.
Ivanova happily informs Sheridan that Clark is having trouble explaining the incident, and notes he won't try it again. Sheridan has been thinking about the Shadow servants, what they took from Z'ha'dum, and where they're going. Unbeknownst to them, on Centauri Prime, Regent Virini is having a bad dream. He gets up and finds a mirror, which reveals a strange alien on his neck.
"Zack is showing some new security guards the ropes at Customs.] Zack Allan: When you come on duty always check this display. This is where you get your details on who to hold, and who to let through. Anything unusual gets flagged. [Londo walks through the gate.] Londo Mollari: And would I fall under the category of unusual, Mr. Allen? Zack: Well! I didn't think we'd be seeing you again any time soon, ambassador. Londo: Yes, I could tell, from the look of unvarnished joy on your face when I came aboard. Perhaps you would like to take a seat before you are overcome with ecstasy? Zack: No thanks, I'm fine. So what happened, they get tired of you back home? Londo: Tired? No, don't be absurd. Why, the Emperor himself said I would only be allowed to leave over his dead body. I thought, "Well, how strange. Mr. Allan said I would only be allowed back onto Babylon 5 over his dead body." With my busy schedule I'm afraid I can only accommodate so many requests. I'm sorry, Mr. Allan, but I'm afraid you'll simply have to wait your turn! [he leaves] Zack: The only reason that guy is still alive is that half the time I don't know what the hell he's talking about. The other half, I wish I didn't. But that's why it's important to check in on customs on a regular basis. [Bester now appears behind him, surrounded by three security guards.] You never know who's gonna walk in that."
– Zack Allan to Londo Mollari
"Alfred Bester: Just a guess, Mr. Allan, but I'd suggest the word you're looking for is "door". Now, please notify the Captain that I'm here. I need to meet with him and the rest of the Command staff ASAP. I assume my usual quarters in the brig are available? I've grown so attached to the place. Zack: For you, Mr. Bester? Always. [Bester and his security escort move on.] Zack: [sighs] You ever have one of those days?"
– Zack Allan to Alfred Bester
"The royal bloodline isn't what it used to be. Too much intermarrying I suppose. I always say: 'When you reduce a family tree to a family bush, you just can't hide as much beneath it.'"
– Minister Milo Virini to Londo Mollari
"I have seen what power does, and I have seen what power costs. The one is never equal to the other."
– G'Kar to Dr. Franklin
The secrets about Lyta's past that Bester alludes to would later be spoken of by Lyta in ("The Face of the Enemy") and were described in detail in J. Gregory Keyes's novel "Deadly Relations - Bester Ascendant".
The events of the story In Valen's Name take place after the celebrations of the end of the Shadow War but before Garibaldi's resignation.
This episode, along with the other episodes from season four, has been released on DVD with extensive special features.
Episode guide page for Epiphanies at the Lurker's Guide
Babylon 5 Season 4 "No Surrender, No Retreat"
<<< Previous Season • "The Hour of the Wolf" • "Whatever Happened to Mr. Garibaldi?" • "The Summoning" • "Falling Toward Apotheosis" • "The Long Night" • "Into the Fire" • "Epiphanies" • "The Illusion of Truth" • "Atonement" • "Racing Mars" • "Lines of Communication" • "Conflicts of Interest" • "Rumors, Bargains and Lies" • "Moments of Transition" • "No Surrender, No Retreat" • "The Exercise of Vital Powers" • "The Face of the Enemy" • "Intersections in Real Time" • "Between the Darkness and the Light" • "Endgame" • "Rising Star" • "The Deconstruction of Falling Stars" • Next Season >>>
Retrieved from "https://babylon5.fandom.com/wiki/Epiphanies?oldid=65322"


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AntibodyCdrug conjugates deliver anticancer providers selectively and efficiently to tumor tissues
July 13, 2017 Zoe West	Leave a comment
AntibodyCdrug conjugates deliver anticancer providers selectively and efficiently to tumor tissues and also have significant antitumor efficiency with a broad therapeutic screen. of cell penetration of released payload is normally correlated towards the strength of bystander getting rid of. Notably, DS\8201a provides high membrane\permeable medication payload and demonstrated stronger bystander eliminating than T\DM1 and anti\HER2 ADC with low cell membrane\permeable payload of topoisomerase I inhibitor, recommending its potential in concentrating on tumors with HER2 heterogeneity, such as for example gastric cancer. Components and Strategies AntibodyCdrug conjugates and chemotherapeutics DS\8201a (anti\HER2\DXd (1)) and anti\HER2\DXd (2) had been synthesized based on the conjugation method defined in another survey17 utilizing the anti\HER2 Ab produced with reference to the same amino acid sequence of trastuzumab and its DAR is approximately 7 to 8. The IgG\DXd (1) and IgG\DXd (2) were synthesized using a method similar to that for DS\8201a and anti\HER2\DXd (2) with purified human being IgG (Bethyl Laboratories, Montgomery, TX, USA.), resulting in similar DAR. T\DM1 was purchased from Genentech Roche (San Francisco, CA, USA), and DXds (1) and (2) and Lys\SMCC\DM1 were synthesized in our laboratory. Cell lines The human being gastric carcinoma cell collection NCI\N87 and the human being breast adenocarcinoma cell collection MDA\MB\468 were purchased from ATCC (Manassas, VA, USA). The human being breast tumor cell collection KPL\4 was provided by Dr. Kurebayashi in the Kawasaki Medical University or college (Kurashiki, Japan). MDA\MB\468\Luc cells were founded by transfecting them with the lentivirus vector (Valent BioSciences Corporation, Libertyville, IL, USA) transporting the luciferase gene. All cell lines were cultured with RPMI 1640 Medium (Thermo Fisher Scientific Inc. Waltham, MA, USA) supplemented with 10% warmth\inactivated FBS at 37C under 5% CO2 atmosphere. Distribution coefficient (log RO4927350 D, pH 7.4) Equal amounts of n\octanol and PBS (pH 7.4) were mixed, shaken, and left for more than 12 h. Each compound remedy in DMSO (10 mM) was added to the perfect solution is (final 100 M comprising DMSO 1%) and shaken vigorously for 30 min at space temp. After centrifugation, the concentration of compound in each phase (top, n\octanol phase; lower, aqueous phase) was measured by an LC\MS/MS system (API 4000; Abdominal Sciex, Framingham, MA, USA). Log D was determined using the following equation: Log D = log (maximum area in n\octanol phase / peak area in aqueous phase). Parallel RO4927350 artificial membrane permeability assay Parallel artificial membrane permeability assay (PAMPA) was carried out using a Freedom EVO200 system (Tecan, M?nnedorf, Switzerland). The filter membrane of the acceptor plate (Stirwell PAMPA Sandwich; Pion, Billerica, MA, USA) was coated with GIT\0 lipid remedy (Pion). Each compound remedy in DMSO (10 mM) was added to Prisma HT buffer (Pion) to obtain 5\M donor solutions (comprising 0.05% DMSO, pH 5.0 and pH 7.4), and then placed on a donor plate. The acceptor plate was filled with an acceptor sink buffer (Pion). The donor plate was stacked onto the acceptor plate and incubated for 4 h at 25C. After incubation, the concentrations of compounds in both plates were measured by an LC\MS/MS system (API 4000). The permeability coefficient (Peff; 10?6 cm/s) was calculated using PAMPA Development DP software (Pion). cell growth assay Cells were seeded inside a 96\well plate at 1000 cells/well for KPL\4 and 2000 cells/well for MDA\MB\468. RO4927350 After over night incubation, a serially diluted remedy of each ADC was added. Cell viability was evaluated after 5 days using a CellTiter\Glo luminescent cell viability assay from Promega (Madison, WI, USA) according to the manufacturer's instructions. For coculture study, KPL\4 and MDA\MB\468 cells had been seeded within a 6\well dish at 1 105 cells and 3 105 cells, respectively, in 2 mL/well lifestyle medium. After right away incubation, the supernatant was taken off the dish RO4927350 and each ADC diluent (10 nM) was added at 6 mL/well. Practical cells had been detached in the dish after 5 times of culture, as well as the cellular number in each well was driven utilizing a cell counter-top. To be able to determine the proportion of KPL\4 and MDA\MD\468 cells of the Rabbit Polyclonal to SEPT7. full total practical cells, the cells had been stained with anti\HER2/nue FITC (Becton, Company and Dickinson, Franklin Lakes, NJ, USA) and incubated on glaciers for 20 min. After cleaning, fluorescent indicators of 2 104 stained cells had been measured utilizing a stream cytometer. Predicated on the real amount and proportion of HER2\positive and HER2\detrimental cells in each treatment well, the true variety of KPL\4 or MDA\MB\468 cells was calculated. xenograft research All studies had been carried out relative to the local suggestions from the Institutional Animal Treatment and Use.
Rabbit Polyclonal to SEPT7.RO4927350
Background EphrinA5, an associate of Eph/Ephrin family, possesses two alternative isoforms,
May 18, 2017 Zoe West	Leave a comment
Background EphrinA5, an associate of Eph/Ephrin family, possesses two alternative isoforms, large ephrinA5 isoform (ephrinA5L) and small ephrinA5 isoform (ephrinA5S). (p?=?0.002) and overall survival (p?=?0.045) in patients with HCC after surgical resection. Functional analysis in HCC cell lines revealed that ephrinA5S had a more potent suppressive impact than ephrinA5L on cell proliferation (p<0.05) and migration (p<0.01). Furthermore, compelled appearance of both ephrinA5 isoforms in HCC cell lines considerably down-regulated epidermal development aspect receptor (EGFR) appearance by marketing c-Cbl-mediated EGFR degradation. Conclusions/Significance EphrinA5S may be a good prognostic biomarker for HCCs after surgical resection. EphrinA5, especially ephrinA5S, acts as a tumor suppressor in hepatocarcinogenesis. Peritumoral small ephrinA5 isoform level could determine the postoperative survival in hepatocellular carcinoma. Introduction Human hepatocellular carcinoma (HCC) is the most common malignancy in the liver and ranks third in cancer-related deaths worldwide [1]. HCC is also the most common cause of malignancy mortality in men and ranks second in women in the annual statement of the Department of Health in Taiwan [2], [3]. Copper PeptideGHK-Cu GHK-Copper The major risk factors are chronic hepatitis infected with hepatitis B and C viruses RO4927350 [4]C[5]. Other etiologies include cirrhosis, alcoholic liver disease, and aflatoxin exposure [5], [6], [7]. The multifactorial etiology may reflect the heterogeneous nature of HCC in pathogenesis. Although multiple treatment modalities are available, its RO4927350 prognosis remains poor [8], [9], [10]. For example, partial hepatectomy is one of the potential curative treatment modalities. However, the recurrence rate is still more than 75% for patients with resectable HCCs in long-term follow-up [11], [12]. It is therefore important to identify specific biomarkers and then to develop helpful therapeutic methods. Studies have reported that aberrant signaling transduction through several groups of receptor tyrosine kinase RO4927350 plays a pivotal role in the carcinogenesis of HCC [13], [14]. Activation of these receptors and their downstream signaling pathways lead to cell proliferation, migration, anti-apoptosis and angiogenesis in HCC [15], [16], [17]. Hence, agents that specifically block their activation and signaling cascade would be useful for treatment of HCC [18], [19]. Therefore, understanding the signaling cascade that is involved in the progression of HCC may facilitate the development of effective diagnostic and therapeutic strategies for HCC patients. The Eph receptors comprise the largest family of receptor tyrosine kinases and interact with their ephrin ligands to form a bi-directional, cell-to-cell signaling communication system [20], [21], [22]. Although Eph receptors have been reported to be involved in a variety of cancers [16], [23], [24], [25], there are only a few studies addressing the genesis of HCC [26], [27], [28]. Ephrins are the ligands of Eph receptors and can be divided into two classes, ephrinA and ephrinB, differing by their modes of attachment to the plasma membrane [22], [29]. EphrinA binds to membrane by a glycosylphosphatidylinositol anchor, whereas ephrinB is usually a transmembrane protein. Based on the similarity of their extracellular domain name sequences and the binding choice to ephrinA or ephrinB, the Eph receptor is certainly split into two equivalent classes, EphB and EphA. The receptor-ligand connections between Eph receptors and ephrins follow an over-all guideline that A-ligands interact preferentially with A-receptors and B-ligands with B-receptors. The just exclusions are that EphA4 and EphB2 connect to ephrinA5 and ephrinB2/3, [30] respectively, [31]. The alteration of ephrin/Eph receptor appearance pattern is RO4927350 certainly correlated with an increase of invasiveness, elevated metastatic potential, and network marketing leads to an unhealthy scientific final result [25] therefore, [32], [33], [34]. EphrinA5, a known member owned by the ephrinA subclass, adversely regulates EGFR by marketing c-Cbl binding and ubiquitination in glioma [35]. EphrinA5 provides two transcript isoforms, like the canonical full-length ephrinA5 (ephrinA5L) and a shorter variant RO4927350 (ephrinA5S), which does not have exon 4 due to choice splicing [36], [37]. In early research, both ephrinA5 isoforms inhibited neurite outgrowth of dorsal main ganglia; nevertheless ephrinA5S acquired a much less inhibitory influence on the mind during advancement [36]. The function of both ephrinA5 isoforms is defined limitedly.
Copper PeptideGHK-Cu GHK-CopperRO4927350

redpajama_set_name: RedPajamaCommonCrawl


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In 1595 Drebbel settled at Alkmaar, where he devoted himself to engraving and publishing maps and pictures. He soon turned to mechanical inventions, for in 1598 a patent was granted to him for a pump and a clock with a perpetual motion. He is mentioned as having built a fountain for the city of Middelburg, in the province of Zeeland, in 1601; and in 1602 he was granted a patent for a chimney. About 1605 Drebbel moved to London. Apparently some of his mechanical inventions appealed to James I, and he was soon taken into the special service of Henry, prince of Wales, and was installed in the castle at Elpham. Drebbel's fame as an inventor became well known on the Continent, and he was visited at Elpham by Emperor Rudolf II and by the duke of Württemberg. He was invited to visit Rudolf, and by October 1610 he was in Prague with his family. Drebbel spent his time at the court of Rudolf showing off his "perpetuum mobile" and probably devoting himself to alchemy. After Matthias, Rudolf's brother, had conquered Prague and deposed Rudolf, Drebbel was imprisoned; through the intervention of Prince Henry, however, he was set free to return to England in 1613. During the next several years Drebbel lived mostly in London, although there are indications that at various times he was on the Continent and again in Prague. About 1620 he began to devote himself to the manufacture of microscopes and to the construction of a submarine. He became acquainted with Abraham and Jacob Kuffler, who with their two other brothers were to become his disciples. Abraham soon married Drebbel's daughter Anna; and Johannes, another brother, married Katherina Drebbel in 1627. The four Kuffler brothers became agents and promoters for the microscopes and other instruments developed by Drebbel, Johannes being the one who did the most to promote Drebbel's inventions after his death. For the next several years Drebbel was employed by the British navy and was concerned mainly with the famous expedition to La Rochelle. In spite of the failure of the expedition to raise the siege, Drebbel continued to work for the navy for some time at a fairly high salary. From 1629 until his death Drebbel was extremely poor and earned his living by keeping an alehouse. He was also engaged in various schemes for draining land near London, but apparently none was successful. Drebbel left very few writings of his own, and none of them is concerned with his inventions. His most famous work was Ein kurzer Tractat von der Natur der Elementum (Leiden, 1608), an alchemical tract on the transmutation of the elements. Later editions contain a description of his "perpetuum mobile." Another treatise, De quinta essentia (Hamburg, 1621), is also alchemical in outlook and was written with the help of a friend. In it, Drebbel discusses extracts from metals, minerals, plants, and other materials and their use in medicine.
An illustration from "Inventions of devices," 1578.
A portrait of Drebbel, c. 1631.
The "Perpetuum mobile" clock by Drebbel.
An illustration of the first navigable submarine.
Drebbel's Perpetuum Mobile in the Album Morsianum.
A small lunar crater was named after Drebbel.
Drebbel was honored on postage stamps issued by the postal service of the Netherlands in 2010.
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Cornelis Jacobszoon Drebbel was a Dutch-born English engineer, inventor and alchemist. He built the first navigable submarine, and also contributed to the development of measurement and control systems, optics, and chemistry.
Cornelis Jacobszoon Drebbel was born c. 1572 in Alkmaar, Netherlands, in an Anabaptist family. His father, Jacob Jansz, a burgher of Alkmaar, was a landowner or farmer. Nothing is known of his mother.
Drebbel probably had only an elementary education, learning to read and write Latin in his later years. As a young man Drebbel was apprenticed to the famous engraver Hendrik Goltzius and lived in his home in Haarlem.
Drebbel proved to be an apt pupil, as is shown by a number of extant engravings from his hand. In addition, he probably acquired an interest in and some knowledge of alchemy from Goltzius, who was an adept.
In 1595 Drebbel settled at Alkmaar, where he devoted himself to engraving and publishing maps and pictures. He soon turned to mechanical inventions, for in 1598 a patent was granted to him for a pump and a clock with a perpetual motion. He is mentioned as having built a fountain for the city of Middelburg, in the province of Zeeland, in 1601; and in 1602 he was granted a patent for a chimney. About 1605 Drebbel moved to London. Apparently some of his mechanical inventions appealed to James I, and he was soon taken into the special service of Henry, prince of Wales, and was installed in the castle at Elpham.
Drebbel's fame as an inventor became well known on the Continent, and he was visited at Elpham by Emperor Rudolf II and by the duke of Württemberg. He was invited to visit Rudolf, and by October 1610 he was in Prague with his family. Drebbel spent his time at the court of Rudolf showing off his "perpetuum mobile" and probably devoting himself to alchemy. After Matthias, Rudolf's brother, had conquered Prague and deposed Rudolf, Drebbel was imprisoned; through the intervention of Prince Henry, however, he was set free to return to England in 1613.
During the next several years Drebbel lived mostly in London, although there are indications that at various times he was on the Continent and again in Prague. About 1620 he began to devote himself to the manufacture of microscopes and to the construction of a submarine.
He became acquainted with Abraham and Jacob Kuffler, who with their two other brothers were to become his disciples. Abraham soon married Drebbel's daughter Anna; and Johannes, another brother, married Katherina Drebbel in 1627. The four Kuffler brothers became agents and promoters for the microscopes and other instruments developed by Drebbel, Johannes being the one who did the most to promote Drebbel's inventions after his death.
For the next several years Drebbel was employed by the British navy and was concerned mainly with the famous expedition to La Rochelle. In spite of the failure of the expedition to raise the siege, Drebbel continued to work for the navy for some time at a fairly high salary. From 1629 until his death Drebbel was extremely poor and earned his living by keeping an alehouse. He was also engaged in various schemes for draining land near London, but apparently none was successful.
Drebbel left very few writings of his own, and none of them is concerned with his inventions. His most famous work was Ein kurzer Tractat von der Natur der Elementum (Leiden, 1608), an alchemical tract on the transmutation of the elements. Later editions contain a description of his "perpetuum mobile." Another treatise, De quinta essentia (Hamburg, 1621), is also alchemical in outlook and was written with the help of a friend. In it, Drebbel discusses extracts from metals, minerals, plants, and other materials and their use in medicine.
Cornelis Jacobszoon Drebbel went down in history as one of the most noyable inventors of his time. He contributed greatly to the development of optics, chemistry, measurement, optics, and is remembered as the builder of the world's first operating submarine.
His other notable inventions included the Perpetuum mobile. Many models of it were used, and Drebbel extended the basic idea to the operation of clocks. Probably his initial fame in England and Europe rested on this invention, which delighted the people of the time.
Drebbel was an expert lens grinder; he made compound microscopes as early as 1619; and some of his biographers insist that he was the actual inventor of the microscope with two sets of convex lenses.
Drebbel's most important contribution in chemistry was his discovery of a tin mordant for dyeing scarlet with cochineal. It is said that the discovery was made by accident when some tin dissolved in aqua regia happened to fall into a solution of cochineal that Drebbel was planning to use for a thermometer.
Among other chemical achievements attributed to Drebbel are the introduction into England of the manufacture of sulfuric acid by burning sulfur with saltpeter and the discovery of mercury and silver fulminates.
Drebbel was honored on postage stamps issued by the postal services of both Mali and the Netherlands in 2010.
A small lunar crater was named after him.
The street "Cornelis Drebbelweg" in Delft, the Netherlands was named after him.
No absolute information on Drebbel's religion is available; but his biographers have concluded that he was most likely an Anabaptist, since most of his friends and relatives were Anabaptists.
According to most of Drebbel's contemporaries, he was a man of gentle manners, considered to possess good intelligence, to be sharp-witted, and to have many ideas about various inventions.
In the strict sense Drebbel was not a scientist but an inventor or practicing technologist. In certain inventions he made use, however, of well-established scientific principles. Unlike many of his predecessors who had been interested in technological inventions, he actually brought his inventions to the practical state, and his finished models worked.
Physical Characteristics: Drebbel was a light-haired and handsome man.
Drebbel married in 1595 one of Goltzius' younger sisters, Sophia Jansdocther. They had at least six children, of whom four survived.


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Love Is a Four-Letter Word
by Cindy | Sep 2, 2009 | Nonfiction, Other | 0 comments
Love Is a Four-Letter Word: True Stories of Breakups, Bad Relationships, and Broken Hearts, Michael Taeckens, ed. Plume (2009), 297 pages.
Essays on love, break-ups, and relationships tend to fall into one of two camps: serious writing—which can come across as self-absorbed and self-pitying (particularly if the writer is young enough to believe his suffering surpasses everything anyone else has ever experienced) or light writing—which risks veering into chick-lit (or, equally unfortunate, lad lit) territory. This collection of twenty-three humorous essays steers clear of both pitfalls. It is light (without being "lite") and almost every essay is very funny and very well-written.
The contributors include many well-known novelists and memoirists: Junot Diaz, Jennifer Finney Boylan, Josh Kilmer-Purcell, Said Sayrafiezadeh, as well as two graphic artists—Lynda Barry and Emily Flake. There are a few weak stories, in particular Brock Clarke's, which begins with a promising first sentence, "She didn't leave me with a broken heart, but she did leave me bleeding from both wrists and lying faceup in a puddle of someone else's vomit, wearing someone else's shirt," but then devolves into pointless repetition and ends with the reader feeling annoyed at having listened to a long tedious story waiting for a payoff that never comes.
Several of the outstanding entries include Jami Attenberg describing a new relationship:
"You realize that he only has one sex trick, the sex against the wall. Like he saw it in a movie once and decided if he could just do that he would be the best lover ever and then he never decided to learn any other trick again. A one-trick pony. You picture him whinnying and waving a long, dirty mane in the air. Pawing the ground sadly."
Wendy McClure's portrayal of the boyfriend we all know is wrong, but she keeps dating him anyway:
"Things that indicated he wasn't quite what I thought he would be, but chose to ignore for the time being:
1. The Guggenheim thing clearly wasn't going to work out, considering the only thing he's published had been a Listmania! list he'd posted on Amazon.com, with his favorite books, mostly surrealist erotica. 'Literary Journeys into the Dark Dreamworld of Sexuality,' the list was called, 'by Benjamin J. Gottlieb, Writer.'
2. He couldn't show me his novel yet or say how long it was because it was still untyped. Like, all of it.
3. He only rode his bike when he couldn't depend on someone (like me) for a ride.
4. He had no driver's license.
5. Or bank account."
And Dave White's hilarious account of the one-night stand who won't go away:
"The sentence, 'My boyfriend likes to _______,' which was This Guy's version of a good morning, is relevant for two reasons. The first reason is that the sexual act he referred to, the one I've self-censored, is, as I've mentioned, a really boring one. But his voice decorated it with a sort of porny Christmas-tree flocking and an icky sensuality that transformed him, in that moment, into a man wearing a Dacron, thigh-length bathrobe, holding a bottle of massage oil in one hand and a box of strawberry-daiquiri-flavored condoms in another… The other relevant fact is that this Guy called me his boyfriend after knowing me approximately eight hours. Not being very hungover at all, I picked up on this, noting it as something of a howling siren of insanity."
Reviewed by Cindy Blackett


Is there anything worthier than life?
A big NO! Not necessarily talking about a rich or poor one but if you have life, that is when you can achieve or do something. Without it all hope is lost.
I can't believe I am gonna say No!!
I hope it's a satisfying kind of life we are talking about. Good health and happiness kind of thing.
No all forms of life remember all are term life, a rich life, a poor life & so on. So then I think nothing is worthier than all these life's in one way or the other a person in one of such forms becomes happy sometimes?


I've recently completed work on a commission for a language coincidentally called Grayis, which you can peruse through over at Linguifex: https://linguifex.com/wiki/Grayis.
Grayis is spoken by the Grayis Kin, a race of space-faring aliens from the planet of Oyrigin, one of six races described in the soon-to-be-released board game Pilots of Gallaxia, designed by Stefan Rasporich of Infinite Mind Pictures, Inc. There will be a crowdfunding campaign launching soon to get the game into production soon: I'll post an update in the comments (below) when the campaign is open!


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Christmas might be an annual event but it's become a very different experience with each decade that goes past. If you grew up in the 1960s then your festive traditions and feasts would have been very different to those for children today. So, what is it that has made a Christmas in each of these decades so very distinctive?
The 1960s was the first decade when turkey really became a tradition on the British Christmas table – preceded by a classic prawn cocktail starter of course. On the drinks menu it was Babycham as the celebratory tipple of choice although you might also have had a glass or two of a Mateus Rose.
On the TV. Three channels showed a range of shows with two of the most popular being Max Bygraves meets The Black and White Minstrels on BBC1, and The Bruce Forsyth Show on ITV.
The 1970s was one decade when "tasteful" and "understated" were two words that most people threw out of the window – especially at Christmas. Cue the mass use of tinsel and an array of wonderfully trashy festive decorations. Turkey was well established as the traditional feast – perhaps preceded by a starter of coloured gelatin Christmas trees or a (bright blue) blue cheese mousse. This was the decade of Cinzano and drinks topped with glacé cherries but it was The Snowball that was the totally festive tipple of choice – Advocaat mixed with lemonade.
Under the tree. If you were lucky then in the 1970s you might have unwrapped a Sooty glove puppet, Scrabble or an Etch-a-Sketch. Twister and Operation were the board games gifted around this time and for the really lucky there may have been a Sindy or a space hopper.
On the TV. You might have started Christmas Day in the 1970s with Basil's Christmas Morning with Basil Brush or Ken Dodd and the Diddymen. The Morecambe and Wise Christmas Show would have been an unmissable event for many and these were the days when everyone still tuned in for The Queen's Speech (the actual Queen, not the Colin Firth film).
Many people think Christmas in the 1980s was the best decade – certainly some of the classic Christmas songs ("Do They Know It's Christmas") and viewing (E.T., Gremlins, Die Hard) came from this decade. It's unlikely you would have attended a Christmas party in the 1980s without eating cheese and pineapple on a stick but turkey was the tradition on Christmas Day. Ready-made food started to appear more widely during this decade, from Christmas puddings to pigs in blankets. Boxing Day wouldn't have been complete without a classic sherry trifle. If you were lucky then champagne would have been your drink of choice for Christmas parties and events – thanks to yuppie culture it suddenly became much more widely consumed.
Under the tree. If you got a Millennium Falcon for Christmas in the '80s then you were probably going to be the most popular kid in school come New Year. Teddy Ruckspin, a My Little Pony Castle or a Rainbow Brite doll would also have been a Christmas win.
On the TV. In the 1980s there were many more options than decades gone by in terms of Christmas Day viewing, from The Man with the Golden Gun to Top of The Pops. The Morecambe and Wise Christmas Show was still a firm fixture or you could have chosen Paul Daniel's Magical Christmas or The Two Ronnies.
Christmas in the 1990s probably bears more of a resemblance to what we recognise nowadays with mass produced turkeys on every table and maybe some Frubes or a Club biscuit to keep you going after breakfast. The tradition of the office Christmas party took hold in this decade with many companies having to write off any productivity the day after as a result. Christmas fizz was now obligatory – whether cava, prosecco or champagne – but for younger generations it was all about the K cider, Malibu and alcopops like Hooch.
Under the tree. The Gameboy was the must-have gift for 1990s kids – either that or a Tamagotchi or a pair of roller blades.
On the TV. For those with young children, Wizbit's Christmas morning show might have been followed by the Songs of Praise Christmas Special. In the afternoon, perhaps a repeat or two, such as Raiders of the Lost Ark, followed by Wogan in Hollywood and Noel's Christmas Presents with '90s TV favourite Noel Edmonds.
During a noughties Christmas it was all about parents trying to get the kids off MSN messenger (as opposed to Snapchat today..). School Christmas discos entered the era of being a fashion-off – babydoll dresses and Buffalo shoes for noughties kids, skinny jeans, ironic tees and fedoras for young people today. Music has remained familiar too – think Beyonce, Lady Gaga and Arcade Fire or the X-Factor winners, such as Leona Lewis and Sam Bailey who have dominated the Christmas Number 1 spot from 2005 to recent years. Christmas dinner could well have been all about the nut roast in the 2000s – a decade when vegetarianism grew at a far faster pace – perhaps accompanied by glasses filled with Smirnoff Ice, WKD or Archers and lemonade. Today, clean eating trends could see more vegan Christmases than ever before. Thankfully, the thirst for alcopops has diminished and you're more likely to be handed a glass of English sparkling wine or perhaps a nice organic red.
Under the tree. For children of the noughties Bob The Builder, Bratz Dolls or a Nintendo Wii would have been the lusted-after gifts of choice. Things haven't changed that much today although Santa will get more requests for smart phones this year than ever before.
On the TV. A Christmas Day in the noughties might have featured The Fresh Prince of Bel Air, singer Charlotte Church or films like Independence Day. Victoria Wood with All the Trimmings provided the laughs and, like today, the listings would be awash with repeats, such as Back to The Future. This year it will be the year of the Christmas Special, from Bake Off, to Strictly Come Dancing. The big Christmas films are all glamour, from The Great Gatsby to Cinderella – with a Home Alone repeat or two for those who pine for Christmases of decades gone by.


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Hellrider
Dodgers Deli
Casa De Montecristo
How to Be Broke Like a Pro
BRANDING // PACKAGING // WEB DESIGN
*this is a fictional rebrand of Casa de Montecristo & Montecristo cigars
ART DIRECTION // Soonduk Krebs
PHOTOGRAPHY // Austen Hart
INSTITUTION // Tyler School of Art
Montecristo Cigars prides themselves on being one of the world's most recognizable cigar brands. In 2016, the cigar distributor opened up a premier cigar bar, marketing themselves as a "modern cigar bar". The problem was that the logo and branding did not reflect this. The challenge was created a new visual identity that reflected Montecristo's long standing history, while giving the brand a refreshing, modern look.
I was inspired by the type based aspect of the original Casa de Montecristo logo, but the typography needed to be redone. To do this, I created a custom typeface that is based off of Futura for a simple and modern feel, but I added subtle flairs to the serifs to convey a sense of elegance. I created decorative elements around the type that were inspired by the movement of smoke. The fleur-de-lis can be seen on the original Montecristo logo that was designed in the 1940's and has been incorporated in the company's branding ever since. To pay homage to this history, I decided to incoporate into my version of the logo.
For application purposes I created a secondary logo. The square ratio of this logo made it easier to apply to certain branding elements such as cigar bands and stationary.
I wanted the logo to have an appeal to both young and old cigar smokers which is why it was important to combine both elegant and sophisticated elements with clean, modern ones.
I wanted to create an aspect of the brand that would draw in the market of people who have not smoked cigars before. To do this, I created a cigar kit intended to teach people how to pair cigars with different types of drinks. The cigar kit comes with different types of cigars, matches, and a booklet about cigar pairing. The chapters of the booklet are organized by different types of drinks, informing the reader on how to pair specific drinks with different cigars.
© Hanah Jang Design 2019


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Ichabod Crane Commencement and Awards
Jun 24, 2019 | Class of 2019, Questar III BOCES, Special Education
Our class at Ichabod Crane High School celebrated the end of the 2018-2019 school year with its annual commencement and service-learning awards ceremony on June 21.
Beth St. Clair-Bedell's class at Ichabod Crane High School held its annual commencement and service-learning awards ceremony on June 21, 2019.
Staff from the Valatie Free Library, Grand Rehabilitation & Nursing at Barnwell, Mud Creek Environmental Learning and Ichabod Crane CSD recognized students for their weekly support of their programs – and the indelible mark they left on others. In fact, Barnwell resident Ernie Gilbert attended and wished the students well.
Questar III School Counselor and Transition Coordinator Sally Lauletta served as the featured speaker. She reminded students to stay focused on five things – dedication, patience, hard work, teamwork and loving what you do.
Kayla Wells received her diploma from Bettina Young, the school psychologist at Catskill CSD. Ichabod Crane High School Principal Craig Shull also presented Kayla with a medal of achievement and said she would forever be an Ichabod Crane Rider.
Kayla delivered remarks about her experiences in the program with her friends. Her and her classmates ended the ceremony with a song and a reception in their classroom.
See more photos on our Facebook page:


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Plot Twister
Adventures in the World of Fiction with Jessica Meats
Queer Reading List
Tag: C B Lee
Posted on 10th February 2019 By jessmeats
Author interview: C B Lee
In this interview, I talk to C B Lee, author of Seven Tears at High Tide and the Sidekick Squad series, about her writing, the importance of LGBTQ+ representation in young adult fiction, and her upcoming books.
You can find out more about C B Lee at her website http://cb-lee.com/
Posted in Author interviews	Tagged author interview, C B Lee, lgbtq+ representation, selkies, superheroes, we need diverse books, young adult
Posted on 26th October 2016 26th October 2016 By jessmeats
Review: Not Your Sidekick by C B Lee
Not Your Sidekick is the story of Jess, a girl born to superhero parents, whose older sister is set to become a superhero too and whose younger brother is intellectually brilliant. She, on the other hand, has no powers and feels that she's not enough for her family's legacy. When she gets offered an internship and discovers she'll be working for her parents' nemeses, she decides to go for it. However, the job is not what she expected, the villains aren't exactly evil, and there's a lot more going on with the battle between heroes and villains than she'd have ever guessed.
The story plays with superhero tropes around powers and secret identities, while simultaneously telling the coming of age story of a teenager trying to figure out who she is in relation to her family. As a character, Jess is relatable. She goes through a lot of very normal things, dealing with school and friends and a crush on her fellow intern. Even in a world of superpowers, Jess is a very human character. She's also the child of immigrants, and this plays nicely into the story of her figuring out who she is. She doesn't want to ignore the heritage of where her parents come from, but she also needs to fit in the society she lives in now.
There are other interesting characters as well. While Jess is the main character, she has interactions with friends, family and strangers. The interplay between the different characters gives the impression of a rich, full world.
The only thing that I feel let this book down was that it didn't really surprise me. In a story of superheroes, a lot of the characters who are introduced also have secret identities and these were sign-posted so much that they might as well have been shining in six-foot neon letters. The identities of various heroes were obvious. There was also a key relationship between a major character and the villains that could be seen coming from miles off. Key plot points were predictable. There was nothing subtle about the hints. There was only one detail of a plot twist in the whole book that came close to surprising me, but I won't spoil that surprise now.
Not Your Sidekick does well from a diversity standpoint. Jess is an Asian bisexual, one of her friends is trans, and there is good representation from both a racial and LGBT+ perspective among the other characters. This representation feels genuine and it adds layers to Jess's character and the overall theme of coming to terms with who you are.
I did enjoy the book. I liked the characters and the story, and there were some entertaining interactions between Jess and some of the other characters, I just wish it could have surprised me a bit more. If you enjoy superhero stories and what a quick read, you'll probably have fun with this one. It's probably a good book for younger readers, who might be less familiar with some of the tropes and who might therefore get a bit more surprised than I was. Three and a half stars.
Posted in Reviews	Tagged C B Lee, Not Your Sidekick, review, science fiction, superheroes
Posted on 31st May 2016 31st May 2016 By jessmeats
Hello there! I'm C.B., a bisexual woman who grew up on the California coast. I work with inner-city youth at a environmental education nonprofit, and teach by day and write by night (although the hours aren't very specific at that.) I'm a first generation Chinese-Vietnamese American and value my mixed cultural heritage, especially the little immigrant neighborhood I grew up in. I love writing and reading stories of all kinds and hope to contribute many to come, especially about characters whose backgrounds are like my own, characters who I never got to read about when I was a teenager.
Now tell us a bit about Seven Tears at High Tide.
Seven Tears at High Tide is my first novel, set in a sleepy seaside town in central California, all about falling in love and having to overcome difficult choices foisted upon you by others. There's a lot of inspiration for the setting from my travels and places I've lived, and I hoped to really transport the reader into a magical, dreamy setting. And I also love and adore all pinnipeds, especially seals, so it was so much fun getting to write about them.
It's also my take on selkie lore, particularly on subverting the trope that follows a lot of the mythology, where a selkie comes ashore and their pelt— and subsequently their freedom— is taken away from them when a human steals it or discovers it. I wanted to write a story where the selkie— and the human both are presented with difficult choices in their relationship, and how they deal with these questions of agency.
What's your favourite part of the book?
Oh, I have many favorites, but I am an absolute sucker for Magical Reveals, there's just so much bundled into this trope that involves trust and building relationships and a character's whole worldview changes. One of my favorite scenes is this twilight scene where Morgan takes Kevin to the beach and I'm rather partial to this bit:
The sky, caught in that nebulous time after sunset, still glows with the energy of the day, and the heavy velvet of night has yet to fall upon them. A few stars gleam through the purple twilight, as if they were too impatient to wait until dark to shine.
There's a really pivotal moment that I'm laying out the scene for here, and I'm quite happy with the imagery and the transitioning themes and the anticipation for what is a huge turning point in the novel.
How did you get into writing?
I write because I love stories. It's when I feel most alive, crafting something out of just emotion and idle thoughts and turning it into something another person can experience— it's a kind of magic, I think. The whole process of telling stories is a such vital part of the human experience, just part of our culture that makes us who we are. How we perceive our lives, what happens to us, our emotions— it's all tied up in stories. The stories we tell each other, about our hopes and dreams, allowing people from all walks of life to see different perspective and to experience so many things. I love writing for many of the same reasons I love reading— not just for the escape factor.
I started very young— I remember writing stories was always my favorite part of school, and definitely remember crayon-scratching too many pages of the adventures of the people in the drawing when it was supposed to be a "brief" description of who they were. In middle school I carried around a notebook that had two ongoing high-fantasy-esque stories, one that started in the front of the book, and one in the back. If I got stuck on one I'd flip to the back and start writing for the other one. I never made it to the middle because I kept adding things and crossing things out; the whole thing was written in pencil. I still have that book, it's all smudged with graphite and nearly illegible but I like to flip through it every now and then and try to make my twelve-year-old self proud.
What's your writing process?
I'm kind of all over the place. I both love outlining and hate it; I'll start with a basic plot structure and idea and then pretty much fly by the seat of my pants for the rest of it, filling out the details as I go. I tend to write scene by scene, occasionally bouncing ahead if I have a particular scene I want to get to, but mostly I write in chronological order and let the story unfold as I write.
A huge challenge for me is keeping in task when I'm motivated; it varies so much, I've gone from utterly wrapped in a scene and writing eight thousand words in a day, to struggling with eight words on an entirely different day. I try my best to stay focused by taking short breaks, timing myself for short bouts of productivity, and moving around to get perspective.
Something I enjoy is writing by hand in places that inspire me. For Seven Tears, I took a journal to the beach and jotted down ideas when I was in San Simeon, where the novel is placed. I live on the California coast, so a lot of beaches and coastside trails factored into my wandering-and-writing habit.
Are there any authors who have particularly inspired you?
Diane Duane, Terry Pratchett, J.K. Rowling, and Neil Gaiman most definitely, for their intricate worlds of magic and worldbuilding and just storytelling in general. Lawrence Yep and Amy Tan were also a huge influence on me for being one of the few voices in literature when I was a child to create amazing characters and stories I could identify with.
Has anything surprised you since getting published?
I think I was pleasantly surprised by how closely knit my publishing house was; it's a small independent publisher, so all the authors and editors and artists and everyone involved was very open about how things worked and introducing authors to each other, and people were very open about helping others who were new to the experience. I'm still very happy about this, how amazing all the support has been from start to finish. I think this isn't exclusive to my publishing house; I've met so many authors from indie houses and the vibe is just so friendly and welcoming. It's been great getting to know other people and other authors and the community of just wanting your peers to succeed is wonderful.
What advice would you give to someone who wants to write novels?
Don't give up. I think it's a very difficult endeavor, and so much of it is a cycle of working incredibly hard on a manuscript and hoping that someone out there will like it. You'll face rejections, plenty of them, and it's definitely hard on your confidence as a writer and a person, but I have such a high value on stories. Write them, write the stories you want to read, ones you want to share.
There's a quote from Erin Bow that is about writing, but I think it applies to life, so, so much.
"No writing is wasted. Did you know that sourdough from San Francisco is leavened partly by a bacteria called lactobacillus sanfrancisensis? It is native to the soil there, and does not do well elsewhere. But any kitchen can become an ecosystem. If you bake a lot, your kitchen will become a happy home to wild yeasts, and all your bread will taste better. Even a failed loaf is not wasted. Likewise, cheese makers wash the dairy floor with whey. Tomato gardeners compost with rotten tomatoes. No writing is wasted: the words you can't put in your book can wash the floor, live in the soil, lurk around in the air. They will make the next words better."
I think this quote is so reassuring, about how no efforts are wasted, and in writing there's often a lot of work that goes unseen, unrecognized, drafts that are torn apart and put back together, chapters thrown out, paragraphs rewritten. It's so easy to get disheartened when you write, but everything you do, it's part of the learning process and just adds to your overall skill and ability as a writer.
I love the quote and think on it a lot as not just for writing, but for life efforts, in the experiences that you have and it's easy to look back and think that something might have been a waste of time, but it contributed to who you are and where you are now, and that's important.
For anyone who wants to write a novel— don't give up. Write it in pieces between your work shifts and half-remembered dreams, write it when you can, between your commitments to that job that pays the bills and your family. It's a hard road, but it's worth it.
If you could sit down for a chat with any author, living or dead, who would it be?
I very deeply admire the late Terry Pratchett, and would love to talk with him and really learn more about his amazing worldbuilding and extensive magic systems. I love his sense of humor and how well crafted all of his novels are; he was such a huge influence on me and I think it would be amazing to get the opportunity to get to know him.
I'm currently working on a young adult scifi adventure series in a post-dystopia world. Not Your Sidekick is the first novel in that series and follows Jess, a high school girl who comes from a family of superheroes— except she's nonpowered, and really just wants to prove herself. She ends up getting an internship, working with her crush, Abby at a mysterious corporation which turns out to be run by the town's supervillain, and these two girls uncover this huge plot that's more than just heroes versus villains. And they also fall in love. Not Your Sidekick will be out September 8 of this year, and I'm really excited about it. I'm working on the second and third of the series at the moment.
If you want to know more about C B Lee and her writing, check out her website, or take a look at her book on Amazon.
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Branding for a Better Indiana: A Case Study
By Matt Gonzales on August 9, 2016
Indiana Protection and Advocacy Services: It's a name that uses a lot of words to say very little. And that's tragic, because it belongs to an organization that does vitally important work. This is the story of how Well Done helped the organization pull off a brand overhaul that will help it pursue its mission more successfully than ever.
The original logo of Indiana Protection and Advocacy Services.
Since 1977, IPAS (the abbreviated sobriquet used by its employees and partners) has worked to protect the legal rights of and advocate for Hoosiers with disabilities, addressing everything from abuse and neglect to discrimination in education and employment.
That explains the name—but a good name should require no explanation. Furthermore, a good name should be memorable and concise. According to IPAS Director of Communication and Outreach Jessica Trimble, the length of the name "Indiana Protection and Advocacy Services" was frequently a liability.
"Just last year, a radio reporter who was having trouble fitting it into her news segment decided to cut it from the story altogether," Trimble said.
When Trimble arrived at IPAS in 2015, the federally funded, independent state agency was undergoing a significant organizational shift. It was the perfect time to address the organization's branding challenges. So Trimble and her team requested proposals from several marketing firms, ultimately choosing Well Done Marketing.
"What set Well Done apart was their robust approach to research," she said. "They understood the importance of getting to know the people we serve, and they took the time to have conversations with audience members and stakeholders that other firms often don't take."
After several weeks of qualitative and quantitative research—including a deep dive into digital analytics, a thorough review of other state P&A agencies, and interviews with IPAS advocates, attorneys, commission members, partners, sibling organizations, and client organizations—Well Done found that IPAS's clients, partners, and associate organizations were eager to see the organization present itself with more clarity and confidence.
Most of all, it became clear that the organization had outgrown its original name. "Indiana Protection & Advocacy Services" was vague and long-winded. Most problematically, it failed to say exactly to whom the organization provided protection and advocacy.
So Well Done recommended a new name: Indiana Disability Rights. Not only does it address the audience that IPAS exists to help, but its comparatively low syllable count leaves plenty of room for a tagline. We arrived at one that describes the organization's mission—and how it achieves it—in three simple words: "Equality through advocacy."
In just six words, the new name and tagline tells the organization's brand story in concise, clear, and compelling language. "It's six great words that really describe what we do," Trimble said. "We couldn't believe that it only took six words."
Indiana Disability Rights rolled out its new identity on June 1 to an "overwhelmingly positive response," Trimble said. "The feedback has been wonderful. And the new name has facilitated us being viewed as experts more quickly."
Not only has the new identity helped the organization present itself to the world with more power and clarity—it has also engendered pride and a sense of purpose among staff members during a critical time in the organization's evolution. "The staff is really excited about the new name," Trimble said. "It really represents what we all do on a day-to-day basis. And that is one of the most exciting things to see—how happy our staff is about the change."
"The new name has facilitated us being viewed as experts more quickly."
Well Done is honored to continue working with Indiana Disability Rights. Currently, we're scripting several online videos aimed at helping people with disabilities understand their voting rights, and making sure poll workers are educated on accessibility at the polls.
Meanwhile, Indiana Disability Rights continues to raise its profile as Indiana's leading authority on the rights of people with disabilities through increased social media activity and a bigger media presence.
Now armed with a strong brand, they're poised for unprecedented success—and that means a more equitable Indiana for people living with disabilities. "This has really made a difference for us," Trimble said. "And it is really helping individuals to live out their best possible lives."
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We have much to be thankful for this holiday season. We are thankful for wonderful clients and the opportunity to help when they need it most. We're thankful for a dedicated team who works diligently on our clients' behalf.
Accidents don't take a holiday. Call or text Rutter Mills any time at 622-5000.


KHALSA Hockey Club's first XI ensured their place in the National League next season after a comfortable win earned them promotion.
Nottinghamshire side Boots travelled to Leamington on Saturday in a match that was never really in doubt, much in part to the solid back line which frustrated the visiting attack.
Aaron Nagra struck the upright from a penalty corner as Khalsa threatened early on, and went ahead through Alex Idoine's finish from Sav Lall's square pass.
They continued to play scintillating hockey and were rewarded with a second – again through Idoine, who thrashed his shot from a penalty corner into the corner.
Patient work in the second-half led to a superb third goal of the game, provided by Adam Croutear.
He dived to meet a driven ball into the centre, and hooked the ball into the net for his first goal for the club.
The points and the promotion were sealed when Idoine claimed his hat-trick from another corner to cap off the victory.
In the final game of the campaign, Khalsa visit second-placed Barford Tigers next week.
Khalsa's second-team were on the wrong end of an 9-0 scoreline, as their trip to promoted Bridgnorth proved a step too far.
They host fifth-placed Old Halesonians in their final fixture of the season.
Meanwhile, the third XI thrashed Sikh Union Coventry 2's thanks to Ricky Saund's double and goals from Sanj Hayer, Dhanraj Saund, Peram Dhillon, Harpreet Hundal and Daljinder Theara.
Elsewhere. Khalsa 4's were unfortunate in a 4-1 away loss to Warwick, with Satvarg Nijjar scoring their only goal of the game.


vCenter Single Sign On aka SSO, what do I recommend?
Complex? Yes I agree, probably too complex for most people. Difficult to digest, and that is not due to Josh's diagramming skills. SSO has various deployment models (multi site, HA, basic), and then there is the option to deploy it centralized or localized as well. On top of that there is also the option to protect it using Heartbeat. Now you can probably understand why the flow diagram ended up looking complex. Many different options but what makes sense?
SSO in HA mode does not make sense as clustering the SSO database is not supported, so although you just deployed an HA solution you still end up with a single point of failure!
You could separate SSO from vCenter, but why would you create a dependency on network connection between the vCenter instance and the SSO instance? It is asking for trouble.
A centralized SSO instance sounds like it make sense, but the problem here is that it requires all connecting vCenter instances to be on the same version. Yes indeed, this complicates your operational model. So go localized for now.
So is there a valid reason to deviate from this? Yes there is and it is called Linked Mode. Linked Mode "requires" SSO to be deployed in a "multi-site" configuration, this is probably one of the few reasons I would not follow the KISS principle when there is a requirement for linked-mode… personally I never use Linked Mode though, I find it confusing.
So there you have it, KISS!
Great post Duncan! I work mostly as an EUC engineer and see multiple vCenters at a single site due to separating the desktop and server environments. I have been recommending to customers that they build a separate VM for SSO and join all vCenters to that instance due to the fact that so many customers want linked mode. However, your note about all vCenters connecting to that SSO instance must be at the same version is a great point that I will have to mention going forward. That scenario forces them to do an all or nothing upgrade.
Can anyone please provide a source on the statement that SSO and all the vCenters themselves need to be the same version? I couldn't find anything that implies this.
When they say "same version" do they mean "same build". A newer build version of SSO would work with an older vCenter version, right?
I agree – we've reverted back to the single server mode for these reasons.
It's worth noting that if you install vCenter with the simple install then you can't just change the SSO mode, you have to re-install using the individual component installation to get the advanced SSO setups. If you think you might need multi-site (or even after the warnings above, HA) SSO at some point in the future then it's best to start off with the individual component install, even if it is on a same server.
Thanks for posting the above Sam – made for interesting discussion here in the office. The only time I've employed Linked Mode (and therefore multi-site SSO) is recently in a proof of concept for SRM 5.0 – everything I'd read (granted not exhaustive research) suggested Linked Mode for the vCenters at protected and recovery sites is best practice.
"personally I never use Linked Mode", I'm with you Duncan, I personally don't use linked mode as well but this is me thinking out loud and arguing both sides what about VMware View? it contradicts VMware's goal when it comes to View. I personally don't use VMware View with linked mode. I personally would rather rely on a good storage to do the compression and dedupe to accomplish what . In fact there are good storage startup that has great idea to where linked-mode would sound like a bad idea. Is it because of the many storage startup that has great idea the reason why you don't use linked mode?
Don't confuse linked mode (vCenter) with linked clones (VDI). This article is referring to the SSO requirements with Linked Mode vCenter servers to enable sharing of roles and licence keys.
Thanks for clarifying, I did got the two technology confused.
I've been considering to change my design to a local SSO for quite some time now, but I haven't found any KB article describing how to change the SSO-server the vCenter uses. Anyone knows if such an article exists?
Great post. I am working on a vSphere 5.1 install and it is obvious there is no one solution that fits all. I had to go for the multi-site implementation because of SRM requirement. My SSO, vCenter and DB backend are on separate servers. The reasoning behind this was that we may implement View and I wanted some level of separation. I still have questions around protecting SSO though and would like to hear what other people do as an alternative to heartbeat? Since I have all services on different servers it becomes more complicated to implement not too mention the cost. I am thinking to about using a powercli script that clones the servers required on an hourly basis to different host/storage. If need be I can log on to local host and fire the VM up. I'd still rely on HA in first instance. Is this viable?
PS: I know Heartbeat keeps things in sync. I said hourly as that seems good enough to me for a "backup".
If I'd rely on our traditional or SAN backup I would not get an hourly RPO.
Here is what we have. We have SSO in HA mode with SQL database on a clustered instance. We also have the VMware Web Client installed on both SSO nodes are load balanced as well using F5. We had a tough time getting the SSO working (I say the issues were more related to getting the certificates working, without a cert it is not possible to configure SSO in a HA or multi-site mode), but with 3rd level support from VMware Canadian engineers our system is working fine now. We now have a proper working SSO and Web client environment. SSO had lot of bugs but now with the new 5.1 Update 1a and Certificate automation tool I think things are more under control now.
In HA mode, only the primary node will have the SSO admin server functionality. That means if the SSO primary is down and the vcenter goes down, to bring back vcenter you need the primary SSO server to be available. (Since Vcenter requires the SSO admin service). There is a work around to make the SSO Secondary server a SSO admin server. But this is not recommended. We have tested this and have not seen any issues so far.
Are there any documentation that says SSO in HA mode is not supported in a clustered database (SQL)?
Our vcenter is still a single point failure, but we will be implementing Heart beat very soon. As of now we have a single vcenter using SQL clustered database as back end and SSO in HA mode with SQL clustered database as back end. We have Web client server services installed on both SSO nodes and are load balanced as well.
When coming to configuring F5 for load balancing there is no documentation from VMware. We are just using F5 as a load balancer and are using the Layer 4 forwarding. No certificates are installed on F5. This setting is same for SSO and Web client.
I'm a big fan of Duncan and his blogs are always a life saver for many. I totally agree with his concept of KISS and if you have not yet implemented SSO, I would suggest sticking with this option. For those who have already implemented SSO in HA and Multi site mode and if it is working, I do not think there is a need to go back. If you want to do so, you have to reinstall SSO completely. No other option.
I still have a question, and expect comments from experts. Why it says SSO is not supported for clustered database? It is working fine for me. Support engineers never said no for this. Are there any documentation from VMware that says, DB clustering for SSO is not supported?
It's my understanding that SSO does not support a distributed/HA database accessible by multiple SSO nodes. Do you foresee this implemented in a future release? This shortcoming is the reason we've decided to install one SSO/SSodb per Vcenter.
Can you provide a link that says SSO in HA mode do not support clusteres SQL instances? I do not see that anywhere in the Vmware Installation document. For us, we are using SSO HA with the help of a clustered SQL database on a multi node MS cluster. We have not experienced any issues and it works great.
I was told distributed databases weren't supported in SSO by my TAM, http://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=2036922 seems to say that distributed databases (not clustered) are only supported when using Multi Site SSO.
Our dev lab design was to have multiple Vcenter's connecting to 2 or more SSO servers backed by 2 or more distributed databases utilizing local accounts (no AD). So, It may be the combination of requirements that led to our answer that it was not supported.
Distrubuted databases and a clustered database are different I think. What we are using is a single database from a Microsoft clusteretd SQL Instance. I do not see any reference that says we should not be using a database that is hosted on a MS cluster.
Duncan: Can you please clarify what you mean by " SSO in HA mode does not make sense as clustering the SSO database is not supported". Does that means SSO does not support a database that is hosted on a MS cluster ?
It means using a database clustering service is not supported for SSO.
How about we deploy SSO and vCetner on the same server. But during the SSO install, we use multi-site mode instead of basic mode, so we only register the local vCenter (i.e.: one SSO with one vCenter on the same VM). In this case we can change the setup to linked mode without reinstall the SSO. Is there any problem with this approach?
I'm So glad there are leading engineers that find KISS still a good way to go. For me its always been about operational \ support efficiency, not necessarily about getting slick with complex solutions, which can sometimes be counter productive to a smooth running infrastructure.
What do folks do re: SSO for the vCenter servers in the vCloud management cluster – I've just received my copy of "VMware vSphere Design 2nd Edition" and noticed the statement "SSO can only be used for cloud adminstrators and not for organizations within the cloud" which I'm not sure I understand. I assume a local SSO for the vCloud management vcenter in each case as per KISS principle..(although the graphics miss out an SSO instance for this vcenter)… do VCD cells still get pointed at customer specific LDAP sources directly rather than use SSO in the real world?
We have a requirement to install SSO in HA mode. I am stuck @ load balancer configuration.
@ Deepu — Can you please suggest me as you have sso in ha in your environment.
Does vShpere 5.5 enhancements to SSO change your recommendation. how bout the increased scale of the vcenter appliance.
How SSO authentication is different from usual AD authentication ?
Thanks for the post Duncan but what still confuses me what exactly is the benefit of SSO that I can actually SEE in my working environment.
1) Open vSphere client/Web client in from 5.1 versions.
2) Enter your AD domain credentials.
3) And you are logged into vSphere infrastructure, can view all the components, you don't need to re-enter your credentials for accessing any component separately.
So we've always been entering our credentials just once to access everything then how this SSO is different.
As by SSO we mean entering your credentials just once while accessing a system & it'll carry on your same set of credentials to it's subsystems preventing you from re-entering the credentials again & again.
I'm still trying to figure this out, if you could help me answering this, would be really helpful.
This just means you can add multiple Identity Sources so that users/groups from other directory services can access your vCenter. Correct me if Im wrong?
Nahhh..that's definitely not the purpose of SSO as majorly anyone is using LDAP for directory services.
in VSphere 5.5 – SSO 5.5 no need of DB and only 3 options available to install the SSO.


Jessica Biel wants her son, Silas, to inherit many qualities from his dad, Justin Timberlake ... except just one.
Jessica Biel hopes her son, Silas, takes after his dad, Justin Timberlake, in many ways. There is one quality, though, she hopes her 2-year-old avoids in the future.
In an interview with news.com.au, the actress said she wants Silas to inherit Timberlake's "charm and his sense of humor." However, when it comes to his career, she doesn't want him to take after dad.
"I really don't want him to be a musician," she said.
Biel clarified that she meant it "sort of as a joke" and "of course" Silas can be whatever he desires. She simply doesn't want her son to become discouraged or feel rejected in the tough music industry.
The star of "The Sinner" told news.com.au that she's seen what Timberlake has gone through and how he's worked years and years to be able to work with any producer he wants and have his songs on the radio. She also noted how much she loves seeing Timberlake play with their son.
She also told news.com.au that being a mother has taught her how to be more patient and compassionate.
"Being a mother has changed everything," she said.


The Newcastle Knights travel north with an unchanged 19-man squad for Sunday's season opener at Cbus Super Stadium against the Gold Coast Titans.
While much of the talk this week has centred around the Club naming five players to make their NRL debut, according to forward Robbie Rochow it was no great surprise.
"We knew this early on in the pre-season when there were 13 or 14 players that hadn't played NRL. We knew that meant in round one we'd have a few debutants," Rochow said after Saturday's captain's run at Wests Mayfield.
"We want them to do the best they can, I am really excited for them to taste NRL and hopefully us older guys can perform really well for them."
Coach Nathan Brown selected David Bhana, Jaelen Feeney, Pat Mata'utia as well as 19-year-old twins Daniel and Jacob Saifiti to make their debut.
"From what they showed in the trials and in training, that gives you confidence," Rochow added.
"Of course they will be nervous, I am nervous, that comes with the game."
For Rochow, the new season is a good chance to get back to his best football after an injury-interrupted 2015.
"I am in the best shape I have been in for a while so I am looking forward to Sunday," Rochow admitted.
He also expects to be challenged by the reduced interchange, after seeing earlier matches in the opening round.
"It looks like less breaks, and it is going to be tough for the 80 minutes players but I am looking forward to it," Rochow said.
As for coming up against the Titans pack, Rochow knows that is always the test no matter the opposition.
"You always have to stop their momentum through the middle, you have to win the ruck," he said.
The Knights take on the Titans at Cbus Super Stadium in the Under 20s at 3.15pm before the NRL match at 5.30pm on Sunday (local times).