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10-11-2014 / всі теми / Україна
Why Ministry of Youth and Sports Opposes the Active Youth?
Чому Мінмолодьспорт виступає проти активної молоді? (укр)
Ministry of Youth and Sports does not want to work with a wide range of civil society organizations. Instead of having to execute a court order, reassign contest of projects for public organizations and establish partnerships with youth and children's organizations, heads of the Ministry refuse to open dialogue, sabotage changes and enter society into astray. Next – details.
Recall that this year Ministry of Youth and Sports, led by Dmytro Bulatov, made very scandalous and opaque competition for the selection of the best projects of youth and children's organizations to fund. Public leaders did not agree and according to democratic procedure filed in court. As a result, on the 14th of October 2014 with significant participation in the process of Studrespublika and other brave – a victory!
What is the situation at the moment? «Unfortunately, we do not see assistance of the Ministry. There is information that they gather materials in the SSU against activists and the Ministry promotes this so that the Minister could use gathered materials against us, but we just defend the rights of the public», – says Stanislav Kutsenko, representative of Ukrainian Student's Association.
On this occasion, we present the opinion of Alla Nehriyenko, head of the All-Ukrainian public children's motion «School of Safety», in fact, the claimant in the case of public organizations against Ministry of Youth and Sports: «Top-management of the Ministry does not want even to talk with leaders of youth and children's organizations. The last example that we, children's public organization, immediately after the trial, on 17th of October, appealed to the leadership of the Ministry with a proposal to establish relations and further cooperation to meet with the leaders of the youth and children's organizations, and again the answer has not received. On sending numerous calls over the minister reception, his deputies we heard in reply that he was on vacation, a business trip, then at the meeting, but finally we were sent to book an appointment through the public reception. They do not want to hear, they do not want to see us!
By the way, in the calendar plan of the Ministry personally I read out very interesting things: it turns out, that the Ministry holds almost monthly a lot of national and international events for youth, about which youth have not even heard. And reports on the implementation of schedules and work plans of the Ministry we have not heard or seen on their official website».
I wonder, what about the opposition of Bulatov and Co. against public organizations, thinks the leadership of Ministry of Youth and Sports? Listen to the First Deputy Minister of Youth and Sports of Ukraine Andrii Vyshniak, who not only does not want to seek consent, but justify for the lost case, and as it turns out, he does not even know the material: «Unfortunately, representatives of Ministry had not been allowed to come to the court, because organizations that were against open competition, they created the conditions, they created pressure on the judge, they created pressure on the representatives of the Ministry, in which hosted such situation».
Instead, National Deputy of Ukraine Vitalii Iliashenko made a remark to Deputy Minister of Youth and Sports: «Bringing a case to court while interacting with youth organizations – a sign of poor communication between the Ministry and the youth».
The lawmaker recommended to the Ministry to pay special attention towards the patriotic education of youth: «The funds that were not used during the competition of projects this year should be sending to the patriotic education of youth through the way of holding directly by the Ministry patriotic summer camps». The politician asked Ministry of Youth and Sports to increase the budget of projects for the next year and to conduct in advance training courses for writing projects to improve their quality.
About the meeting of the Public Council of the Ministry of October, 31, where of course, was discussed the crisis situation in the state youth policy, said one of the leaders of Studrespublika Olexander Shcherba: «Andrii Vyshniak about the court case, said not about the plan of dialogue how to solve the conflict with civil society, but told again that… supposedly, public associations organized pressure on the court, because of what the judge called Vyshniak and allegedly, at the trial was an authorized representative of the Ministry, who has seen this pressure. Such frank come–offs I have not heard! In the interview with DAR-TV, he said that the representative of the Ministry was not allowed – and at the meeting of the Public Council said that the representative of the Ministry was there… In fact, there is a court order where indicated that on 14th of October there was no one from the Ministry, and after that they stupidly frostbite. If a European official became so tangled in lies, how would he done?!»
Unfortunately, in the leadership of Ministry of Youth and Sports we have a classical situation of abusing of power. Youth and children's organizations shared into the correct – their and wrong – not their. To their – financial and organizational support, not to their – good words about the openness and transparency. But when it came up to the court, the officials do not disdain lies and even intimidation. We, the public, must stop this!»
«Too bad that positive changes did not happen in the work with civil society in Ukraine, at least in something that concerns youth. Lies, manipulation, falsification, we suspect that even corruption», – sums up the chairman of Student Republic Pavlo Viknyanskyy.
Activists won in a court against the Ministry of Youth and Sports
Автор: Information from DAR-TV, own information


This species may be one of Melissa's favorite solely for its coloration. Which might make her vain, but whatever. The leopard chimaera, Chimaera panthera, also has the coolest scientific name, in her opinion.
C. panthera is a large chimaera (1.29 meters) who, yes, does resemble a leopard with its reticulations and spots that cover all of its body. A light grey-brown to dark brown in color, they are certainly the most distinguishable of all chimaeras. They have a short, rounded snout and rather large eyes with a tall first dorsal fin (that is also equipped with a protective spine that is equal in height to the dorsal fin). The second dorsal fin, as we've seen present in the Chimaeridae family, is evenly long until the tip of the tail.
Their pectoral fins are triangular with a rounded tip, while their pelvic fins are large and rather round in shape. Their skin is smooth, and sometimes deciduous.
These chimaera are known from the deep waters off of the northern New Zealand Island (see Lord Howe Rise, West Norfolk Ridge, Colville Ridge and Ritchie Banks). Here, they can be observed at depths of 327 – 1020 meters; they are benthic.
Their reproductive method is oviparous, but because this is the rarest New Zealand chimaera, not much else is known about its biology. If you find a specimen, you should send it to the National Fish Collection so we can all learn more!
Reticulation: A pattern of intertwined lines resembling a net.


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Q: SQL query INSERT not working inserting values into my DB I'm trying to insert some values into my DB but it's not working, i'm trying to figure out why it's not working but I'm an amateur php coder,
This is the code I'm using:
$insert = mysql_query
    ("
    INSERT INTO news(id,title,body,date,by)
    VALUES ('NULL','".$title."','".$body."','".$date."','".$by."')
    ");
    mysql_close($connect);

And the rows i'm trying to insert into are: id,title,body,date,by
but it's not showing up in the database or on my news page.
Can someone please help me?

A: by is a special keyword.  Try wrapping the column names in tick marks:
INSERT INTO news(`id`,`title`,`body`,`date`,`by`)

A: I would expect id to be your primary key.  It should not allow a null value.  If it is auto incrementing you might try this:
$insert = mysql_query
    ("
    INSERT INTO news(title,body,date, by)
    VALUES ('".$title."','".$body."','".$date."','".$by."')
    ");

Others have noted by is a reserved word so you will need to quote it.  It is best to avoid naming database objects using reserved words. Consider renaming the by column to author.
You should consider making changing the query into a prepared statement. See How can I prevent SQL injection in PHP?.

A: Try calling mysql_error() to get the error message:
http://php.net/manual/en/function.mysql-error.php

A: First of all, don't put the single quotes around NULL or else it will be entered as a string.
Also, I am assuming that you are using mysql_real_escape_string to sanitize $title, $body, etc.
$title = mysql_real_escape_string($title);
$body  = mysql_real_escape_string($body);
$date  = mysql_real_escape_string($date);
$by    = mysql_real_escape_string($by);

As mellamokb pointed out, by and date are special keywords. It's best practice to put ticks around your columns (and table names). (this will fix your query)
$query = "INSERT INTO `news` (`id`, `title`, `body`, `date`, `by`) VALUES
      (NULL, '" . $title . "', '" . $body . "', '" . $date . "', '" . $by . "');";
if ($insert = mysql_query($query, $connect)) {
    // Success!
} else {
    echo 'MySQL Error: ' . mysql_error($connect); // this will tell you whats wrong
}
mysql_close($connect);

A: I recommend using sprintf & mysql_real_escape_string to handle SQL injection attack possibilities:
$insert = sprintf("INSERT INTO news
                    (id, title, body, date, `by`)
                   VALUES
                     (NULL,'%s','%s','%s','%s')",
                   mysql_real_escape_string($title),
                   mysql_real_escape_string($body),
                   mysql_real_escape_string($date),
                   mysql_real_escape_string($by));

$result = mysql_query($insert) or die(mysql_error());

This will let you know what error is encountered too.
That said, there are numerous potential issues:

*

*by is a reserved keyword, you need backticks to escape its use in MySQL (see example above).  The alternative is to rename the column to something that is not a reserved word -- backticking every column and/or table name hides such issues rather than learning

*NULL should not be inside of single quotes, or it will be interpreted as a string; DEFAULT would be another option if there's a DEFAULT constraint on the column

*the date column should be either a DATE, DATETIME or TIMESTAMP data type rather than string in order to use MySQL Date/Time functionality, and should be using DATE_FORMAT if the value will not be a MySQL standard date format

redpajama_set_name: RedPajamaStackExchange


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Find out the level of training and experience that the specialist has in doing massage. Massaging is not something that anyone can provide. It is a service that requires you to be highly committed and learn the best ways to do it. Find out if their license is updated and how long they have been in that business. Feel free to ask this and get the answer because they are handling our body and that matters.


text:
Country offers vast incentives to foreign investors, says Rahimtoola
Last Updated on Tuesday, 30 November 1999 05:00	Written by Shumaila Ahmed	Thursday, 02 May 2013 11:22
Islamabad: Pakistan�s investment policy is to actively seek foreign investment by offering a broad array of incentives to attract new capital inflows.
This was stated by Maqbool H. H. Rahimtoola, Minister for Commerce, who is leading the Pakistan delegation at the Annual Investment Meeting (AIM) in Dubai, a press release received here Wednesday said.
The Minister pointed out that investment policy of Pakistan is very liberal and opens new vistas to local as well as foreign investors for investment in various sectors of economy so as to keep Pakistan competitive in international market and make it a viable place for foreign investment.
The World Bank, he said, has ranked Pakistan at number three in South Asia in comparison to other countries including India, Sri Lanka and Bangladesh in �ease of doing business�.
�This higher ranking indicates better and stronger regulation for business and better protection of property rights and it also highlights Pakistan�s openness for trade and investment,� he added.
He said confidence of the investors can be seen from the fact that the Karachi Stock Exchange has gone up by 394% since January 2009 to the close on this last Friday.
�This increase is not speculative, it is based on the rate of return and growth displayed by these companies� dividends and profits,� he emphasized.
Chairman Sindh Board of Investment, Zubair Motiwala made a comprehensive briefing on investment policies, incentive package and tremendous potential available in the field of oil and gas, agriculture and energy sector and highlighted the policy parameters which allow 100 percent foreign equity in the major sectors and full repatriation of profits and dividends in all the sectors.

redpajama_set_name: RedPajamaCommonCrawl


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https://read.qxmd.com/read/31928077/genetically-determined-high-levels-of-iron-parameters-are-protective-for-coronary-artery-disease
Genetically Determined High Levels of Iron Parameters Are Protective for Coronary Artery Disease.
Niels Grote Beverborg, M Abdullah Said, Haye H van der Wal, Niek Verweij, Peter van der Meer, Pim van der Harst
The observation that premenopausal women have a relatively low incidence of heart disease led in the nineteen eighties to the hypothesis that iron deficiency protects against heart diseases. These early observations were followed-up by conflicting epidemiological data. To confer causal relationships from epidemiological data is challenging as results can be influenced by residual confounding or reverse causation. For bias reduction, an alternative analysis strategy utilizing single-nucleotide polymorphisms (SNPs) as instrumental variables (Mendelian Randomization) has been developed...
January 12, 2020: Circulation. Genomic and Precision Medicine
https://read.qxmd.com/read/31887778/a-comprehensive-sequencing-based-analysis-of-allelic-methylation-patterns-in-hemostatic-genes-in-human-liver
A Comprehensive Sequencing-Based Analysis of Allelic Methylation Patterns in Hemostatic Genes in Human Liver.
Martina Olsson Lindvall, Marcela Davila Lopez, Sofia Klasson, Lena Hansson, Staffan Nilsson, Tara M Stanne, Christina Jern
Characterizing the relationship between genetic, epigenetic (e.g., deoxyribonucleic acid [DNA] methylation), and transcript variation could provide insights into mechanisms regulating hemostasis and potentially identify new drug targets. Several hemostatic factors are synthesized in the liver, yet high-resolution DNA methylation data from human liver tissue is currently lacking for these genes. Single-nucleotide polymorphisms (SNPs) can influence DNA methylation in cis which can affect gene expression. This can be analyzed through allele-specific methylation (ASM) experiments...
December 30, 2019: Thrombosis and Haemostasis
https://read.qxmd.com/read/31883534/associations-between-gucy1a3-genetic-polymorphisms-and-large-artery-atherosclerotic-stroke-risk-in-chinese-han-population-a-case-control-study
Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study.
Jian-Li Li, Liu-Yu Liu, Dong-Dong Jiang, Yi-Ying Jiang, Guo-Qiu Zhou, Dong-Can Mo, Man Luo
BACKGROUND: Previous genome-wide association studies have found two single nucleotide polymorphisms (SNP) rs7692387 and rs1842896 located on or near the GUCY1A3 gene were associated with coronary artery disease (CAD). GUCY1A3 was considered to be involved in the process of atherosclerosis, but there was little information about the association between genotypic polymorphisms of the GUCY1A3 and large artery atherosclerotic (LAA) stroke. This study aimed to investigate the associations between the GUCY1A3 rs7692387, rs1842896 polymorphisms and LAA stroke susceptibility...
December 28, 2019: Lipids in Health and Disease
https://read.qxmd.com/read/31877157/associations-of-systemic-serum-lipid-and-lipoprotein-metabolic-pathway-gene-variations-with-polypoidal-choroidal-vasculopathy-in-china
Associations of systemic, serum lipid and lipoprotein metabolic pathway gene variations with polypoidal choroidal vasculopathy in China.
Ningda Xu, Hui Xu, Mingwei Zhao, Yongsheng Xu, Lvzhen Huang
BACKGROUND: To investigate the association of systemic, serum lipids and genetic variants in the high-density lipoprotein (HDL) metabolic pathway with polypoidal choroidal vasculopathy (PCV) in China. METHODS: The case-control study was included 150 controls and 66 cases with PCV. Serum levels of total cholesterol (TC), low-density lipoprotein (LDL), HDL, triglycerides (TG), apolipoprotein A1 (APOA1), apolipoprotein B (APOB) together with systemic risk factors including gender, hyperlipidemia, diabetes mellitus (DM), hypertension, coronary artery disease (CAD) and asthma were identified...
2019: PloS One
https://read.qxmd.com/read/31841051/no-causal-effects-of-plasma-homocysteine-levels-on-the-risk-of-coronary-heart-disease-or-acute-myocardial-infarction-a-mendelian-randomization-study
No causal effects of plasma homocysteine levels on the risk of coronary heart disease or acute myocardial infarction: A Mendelian randomization study.
Liu Miao, Guo-Xiong Deng, Rui-Xing Yin, Rong-Jun Nie, Shuo Yang, Yong Wang, Hui Li
BACKGROUND: Although many observational studies have shown an association between plasma homocysteine levels and cardiovascular diseases, controversy remains. In this study, we estimated the role of increased plasma homocysteine levels on the etiology of coronary heart disease and acute myocardial infarction. METHODS: A two-sample Mendelian randomization study on disease was conducted, i.e. "coronary heart disease" ( n = 184,305) and "acute myocardial infarction" ( n = 181,875)...
December 16, 2019: European Journal of Preventive Cardiology
https://read.qxmd.com/read/31817859/plasma-phospholipid-fatty-acids-fads1-and-risk-of-15-cardiovascular-diseases-a-mendelian-randomisation-study
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Shuai Yuan, Magnus Bäck, Maria Bruzelius, Amy M Mason, Stephen Burgess, Susanna Larsson
Whether circulating fatty acids (FAs) play a causal role in the development of cardiovascular disease (CVD) remains unclear. We conducted a Mendelian randomisation study to explore the associations between plasma phospholipid FA levels and 15 CVDs. Summary-level data from the CARDIoGRAMplusC4D, MEGASTROKE, and Atrial Fibrillation consortia and UK Biobank were used. Sixteen single-nucleotide polymorphisms (SNPs) associated with ten plasma FAs were used as instrumental variables. SNPs in or close to the FADS1 gene were associated with most FAs...
December 7, 2019: Nutrients
https://read.qxmd.com/read/31781165/genetic-and-functional-variants-analysis-of-the-gata6-gene-promoter-in-acute-myocardial-infarction
Genetic and Functional Variants Analysis of the GATA6 Gene Promoter in Acute Myocardial Infarction.
Zhaoqing Sun, Shuchao Pang, Yinghua Cui, Bo Yan
Background: Acute myocardial infarction (AMI) which is a specific type of coronary artery disease (CAD), is caused by the combination of genetic factors and acquired environment. Although some common genetic variations have been recorded to contribute to the development of CAD and AMI, more genetic factors and potential molecular mechanisms remain largely unknown. The GATA6 gene is expressed in the heart during embryogenesis and is also detected in vascular smooth muscle cells (VSMCs), different human primary endothelial cells (ECs), and vascular ECs in mice...
2019: Frontiers in Genetics
https://read.qxmd.com/read/31753007/genetic-variants-in-humanin-nuclear-isoform-gene-regions-show-no-association-with-coronary-artery-disease
Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease.
Mall Eltermaa, Maili Jakobson, Meeme Utt, Sulev Kõks, Reedik Mägi, Joel Starkopf
OBJECTIVE: Coronary artery disease contributes to noncommunicable disease deaths worldwide. In order to make preventive methods more accurate, we need to know more about the development and progress of this pathology, including the genetic aspects. Humanin is a small peptide known for its cytoprotective and anti-apoptotic properties. Our study looked for genomic associations between humanin-like nuclear isoform genes and coronary artery disease using CARDIoGRAMplusC4D Consortium data...
November 21, 2019: BMC Research Notes
https://read.qxmd.com/read/31747862/effect-of-sex-and-underlying-disease-on-the-genetic-association-of-qt-interval-and-sudden-cardiac-death
Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death.
Rebecca N Mitchell, Foram N Ashar, Marjo-Riitta Jarvelin, Philippe Froguel, Nona Sotoodehnia, Jennifer A Brody, Sylvain Sebert, Heikki Huikuri, John Rioux, Philippe Goyette, Charles E Newcomb, M Juhani Junttila, Dan E Arking
Background Sudden cardiac death (SCD) accounts for ≈300 000 deaths annually in the United States. Men have a higher risk of SCD and are more likely to have underlying coronary artery disease, while women are more likely to have arrhythmic events in the setting of inherited or acquired QT prolongation. Moreover, there is evidence of sex differences in the genetics of QT interval duration. Using sex- and coronary artery disease-stratified analyses, we assess differences in genetic association between longer QT interval and SCD risk...
December 3, 2019: Journal of the American Heart Association
https://read.qxmd.com/read/31744542/genetic-variants-of-vegfr-1-gene-promoter-in-acute-myocardial-infarction
Genetic variants of VEGFR-1 gene promoter in acute myocardial infarction.
Haihua Wang, Shufang Zhang, Na Wang, Jie Zhang, Mingkai Chen, Xiaohui He, Yinghua Cui, Shuchao Pang, Bo Yan
BACKGROUND: Coronary artery disease (CAD) including acute myocardial infarction (AMI) is a common complex disease caused by atherosclerosis. Vascular epithelial growth factor receptor-1 (VEGFR-1) stimulates angiogenesis and vascular permeability, and functions as a decoy to sequester VEGF and prevent initiation of intracellular signaling. VEGFR-1 knockout mice exhibit significantly higher mortality due to heart failure, cardiac hypertrophy, and cardiac dysfunction. An evident increase in macrophage infiltration and cardiac fibrosis are also observed after transverse aortic constriction...
November 19, 2019: Human Genomics
https://read.qxmd.com/read/31692815/-vegf-c-gene-polymorphisms-increase-susceptibility-to-rheumatoid-arthritis
VEGF-C Gene Polymorphisms Increase Susceptibility to Rheumatoid Arthritis.
Chengqian Dai, Shu-Jui Kuo, Sung-Lin Hu, Chun-Hao Tsai, Yuan-Li Huang, Chien-Chung Huang, Lihong Wang, Guohong Xu, Chen-Ming Su, Chih-Hsin Tang
Vascular endothelial growth factor C (VEGF-C) promotes angiogenesis, a prominent feature in rheumatoid synovitis, contributing to the perpetuation of the global burden of rheumatoid arthritis (RA). VEGF-C gene polymorphisms predict the risk of developing various human diseases, such as urothelial cell carcinoma, oral cancer and coronary artery disease. We sought to determine whether single nucleotide polymorphisms (SNPs) of the VEGF-C gene can predict the risk of RA. Our study recruited 210 patients with RA and 373 healthy controls between 2007 and 2015, and performed comparative genotyping for SNPs rs7664413, rs11947611, rs1485766, rs2046463 and rs3775194...
2019: International Journal of Medical Sciences
https://read.qxmd.com/read/31692368/associations-between-microrna-polymorphisms-and-development-of-coronary-artery-disease-a-case-control-study
Associations Between microRNA Polymorphisms and Development of Coronary Artery Disease: A Case-Control Study.
Hao Qiu, Zheng Chen, Lu Lv, Weifeng Tang, Rong Hu
Coronary artery disease (CAD), a common cardiovascular disease, has become a vital cause of mortality worldwide. Genetic microRNA ( miR ) polymorphisms might contribute to CAD susceptibility. In this study, we selected miR-146a , miR-196a2 , and miR-499 single nucleotide polymorphisms and conducted a case-control study. In total, 505 CAD cases and 1109 controls were recruited. We used SNPscan™ genotyping assay to obtain genotyping of miR rs2910164, rs11614913, and rs3746444 variants. We found that miR-196a2 rs11614913 T > C decreased the susceptibility of myocardial infarction (MI) (TC vs...
November 6, 2019: DNA and Cell Biology
https://read.qxmd.com/read/31690775/effects-of-blood-lead-on-coronary-artery-disease-and-its-risk-factors-a-mendelian-randomization-study
Effects of blood lead on coronary artery disease and its risk factors: a Mendelian Randomization study.
C Mary Schooling, Glen D Johnson, Jean Grassman
Lead is pervasive, although lead exposure has fallen in response to public health efforts. Observationally, lead is positively associated with cardiovascular disease and hypertension. We used separate-sample instrumental variable analysis with genetic instruments (Mendelian randomization) based on 13 single nucleotide polymorphisms (SNP), from a genome wide association study, strongly (p-value < 5 × 10-6 ) and independently associated with blood lead. These SNPs were applied to a large extensively genotyped coronary artery disease (CAD) study (cases = <76014, controls = <264785) largely based on CARDIoGRAPMplusC4D 1000 Genomes and the UK Biobank SOFT CAD, to the UK Biobank (n = 361,194) for blood pressure and to the DIAGRAM 1000 genomes diabetes case (n = 26,676)-control (n = 132,532) study...
November 5, 2019: Scientific Reports
https://read.qxmd.com/read/31679296/adamts7-and-zc3hc1-share-genetic-predisposition-to-coronary-artery-disease-and-large-artery-ischemic-stroke
ADAMTS7 and ZC3HC1 Share Genetic Predisposition to Coronary Artery Disease and Large Artery Ischemic Stroke.
Simin Jafaripour, Payam Sasanejad, Malihe Dadgarmoghaddam, Ariane Sadr-Nabavi
Coronary artery disease (CAD) and ischemic stroke (IS) are commonly considered distinct disease phenotypes. However, there is some evidence in favor of a degree of overlap between genetic susceptibility to CAD and genetic risk factors for IS. In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population...
2019: Critical Reviews in Eukaryotic Gene Expression
https://read.qxmd.com/read/31639433/nlrp3-is-associated-with-coronary-artery-disease-in-vietnam-veterans
NLRP3 is associated with coronary artery disease in Vietnam veterans.
Wole Akosile, Joanne Voisey, Bruce Lawford, David Colquhoun, Ross McD Young, Divya Mehta
BACKGROUND: Previous studies have established that coronary artery disease is associated with excess inflammation. These studies have shown an elevation of both pro and anti-inflammatory cytokines in sufferers of coronary artery disease. There is increasing interest in the role played by the inflammasome Nod Like Receptor family pyrin domain containing 3 (NLRP3) in the aetiology of coronary artery disease. Increased severity of coronary artery disease correlates with higher levels of expression of NLRP3...
October 19, 2019: Gene
https://read.qxmd.com/read/31605122/down-regulated-rgs5-by-genetic-variants-impairs-endothelial-cell-function-and-contributes-to-coronary-artery-disease
Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.
Yang Li, Han Yan, Jian Guo, Yingchun Han, Cuifang Zhang, Xiuying Liu, Jie Du, Xiao-Li Tian
AIMS: Genetic contribution to coronary artery disease (CAD) remains largely unillustrated. Although transcriptomic profiles have identified dozens of genes that are differentially expressed in normal and atherosclerotic vessels, whether those genes are genetically associated with CAD remains to be determined. Here, we combined genetic association studies, transcriptome profiles and in vitro and in vivo functional experiments to identify novel susceptibility genes for CAD. METHODS AND RESULTS: Through an integrative analysis of transcriptome profiles with genome-wide association studies for CAD, we obtained 18 candidate genes and selected one representative SNP for each gene for multi-centered validations...
October 12, 2019: Cardiovascular Research
https://read.qxmd.com/read/31599812/clinical-and-genetic-contributors-to-new-onset-atrial-fibrillation-in-critically-ill-adults
Clinical and Genetic Contributors to New-Onset Atrial Fibrillation in Critically Ill Adults.
V Eric Kerchberger, Yi Huang, Tatsuki Koyama, M Benjamin Shoemaker, Dawood Darbar, Julie A Bastarache, Lorraine B Ware, Ciara M Shaver
OBJECTIVES: New-onset atrial fibrillation during critical illness is an independent risk factor for mortality. The ability to identify patients at high risk for new-onset atrial fibrillation is limited. We hypothesized that genetic susceptibility contributes to risk of new-onset atrial fibrillation in the ICU. DESIGN: Retrospective sub-study of a prospective observational cohort study. SETTING: Medical and general surgical ICUs in a tertiary academic medical center...
January 2020: Critical Care Medicine
https://read.qxmd.com/read/31597446/novel-genetic-locus-influencing-retinal-venular-tortuosity-is-also-associated-with-risk-of-coronary-artery-disease
Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease.
Abirami Veluchamy, Lucia Ballerini, Veronique Vitart, Katharina E Schraut, Mirna Kirin, Harry Campbell, Peter K Joshi, Devanjali Relan, Sarah Harris, Ellie Brown, Suraj S Vaidya, Baljean Dhillon, Kaixin Zhou, Ewan R Pearson, Caroline Hayward, Ozren Polasek, Ian J Deary, Thomas MacGillivray, James F Wilson, Emanuele Trucco, Colin N A Palmer, Alexander S F Doney
OBJECTIVE: The retina may provide readily accessible imaging biomarkers of global cardiovascular health. Increasing evidence suggests variation in retinal vascular traits is highly heritable. This study aimed to identify the genetic determinants of retinal vascular traits. Approach and Results: We conducted a meta-analysis of genome-wide association studies for quantitative retinal vascular traits derived using semi-automatic image analysis of digital retinal photographs from the GoDARTS (Genetics of Diabetes Audit and Research in Tayside; N=1736) and ORCADES (Orkney Complex Disease Study; N=1358) cohorts...
December 2019: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/31592210/circulating-vitamin-e-and-cardiometabolic-measures-a-mendelian-randomization-analysis
Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis.
Chuanlong Fan, Tao Huang, Xuejun Kong, Xiaohong Zhang, Zuquan Zou, Jing Xiao
Although a large body of literature reported that high intake of vitamin E played a possible role in reducing risk of cardiometabolic diseases, conflicting results were also found in some observational studies due to confounding factors. Hence, we used a Mendelian randomization study as an alternative way to examine the causality between circulating vitamin E and cardiometabolic diseases. Summary-level data were extracted from consortia and three single nucleotide polymorphisms were used as instrumental variables...
September 2019: Journal of Clinical Biochemistry and Nutrition
https://read.qxmd.com/read/31578885/the-relationship-between-cyp7a1-polymorphisms-coronary-artery-disease-serum-lipid-markers
The relationship between CYP7A1 polymorphisms, coronary artery disease & serum lipid markers.
Tomasz Iwanicki, Anna Balcerzyk, Paweł Niemiec, Wanda Trautsolt, Władysław Grzeszczak, Anna Ochalska-Tyka, Jolanta Krauze, Tomasz Nowak, Iwona Żak
Polymorphic variants of the CYP7A1 gene can increase the risk of atherosclerosis-based coronary artery disease (CAD) and modify serum lipid markers. Method: We studied haplotype-tagging single nucleotide polymorphisms of CYP7A1 in the Caucasian population and if they are associated with CAD, its symptoms, and any of its risk factors. Results: We did not find the genetic variants of CYP7A1 to be associated with an increased risk of CAD. However, we did find that the common rs3808607 variant is associated with modified concentrations of serum total cholesterol and LDL...
October 3, 2019: Biomarkers in Medicine
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We start each day after a short play and settling time with a Welcome Circle. The children enjoy gathering together as a group, sharing their news with friends and hearing about activities available that day. When appropriate we discuss any Golden Rules that might help that day, weather, birthdays, days of the week, and the sharing of special events. We encourage listening to others and taking turns to speak by sharing the 'Talking Stick'. This time is also used for highlighting current themes and feedback from the children about what they enjoy or would like to learn more about.
We have an exciting outdoor environment with vegetable planters, mud kitchen, willow archway, bug hotel, circle time seating area and conker cave. Children can explore using all their senses and engage in plenty gross motor movements. The ethos of our pre school is based around our outdoor provision and our ECO Flag status.
We have an inviting book corner with an adult story telling seat. We share stories here and can choose to write and mark make with plenty resources to explore. We record many ideas and stories in a floor story format that can be revisited during the year.
Our numeracy space has plenty maths construction, puzzles and 'placing and arranging'. We provide opportunities to explore shape, space, measure and pattern as well as number and counting.
Here the children can engage in role play and dress up, which builds on and reflects their everyday experiences. We change our role play area regularly and it usually supports our topic or theme.
We give the children plenty opportunity to explore textures and materials using all their senses. We understand that sensory play supports brain development in early childhood.
We aim to give the children the opportunity to explore a wide range of materials. We are very adventurous in our art and design provision- we use the 'art and literacy' methodology and provide children with much challenge in all areas of creativity.
We have a range of software designed for pre-school children. We try to encourage mouse control and allow the children to become familiar with using a computer. We also encourage children to use the ipad to access their online learning journal and to take videos and pictures. We have beebot programmable toys for the children to play with.
We are passionate about music, song and dance and have regular circle time sessions where we use the musical instruments and dance to a wide range of music from around the world. We use the guitar to sing with the children and often invite musicians to work with the children.
We have a variety of construction toys and "small world" LegoTM and DuploTM bricks. The children use these in a variety of ways including problem solving and imaginative play.
We often end the session with a story. We also gather together after play to read different stories in small groups when we settle down for circle time. We have keyworker time every week and stories are shared during these sessions.


text:
Liver Cancer Increased in High-Income Countries
Liver Cancer Increased in High-Income…
The incidence of liver cancer and deaths from the disease have doubled since the early 1990s in several high-income countries, including the United States, Canada, Australia, and the United Kingdom.
Liver cancer is the only primary cancer where mortality is increasing in these countries, new findings indicate. "Many of these liver cancers strike people in their 50s when they are still of working age," Morris Sherman, MD, emeritus professor of medicine, University Health Network and the University of Toronto, Ontario, Canada, said in a statement.
"The prospects for surviving liver cancer are bleak, so our only hope is to intervene early and prevent cancer happening in the first place or to find early curable cancers," he added. Data for an age-standardized incidence rate per 100,000 population show that liver cancer rates have increased sharply in all four countries since the early 1990s.
Overall, the highest incidence is in the United Kingdom, at an age-standardized incidence rate of 9.6 per 100,000 in 2015, followed by 9.2 per 100,000 in the United States, 7.4 per 100,000 in Australia, and 6.0 per 100,0000 in Canada.
Deaths from liver cancer have similarly increased among men and women, again based on age-standardized death rates per 100,000 population. In 2014, the age-standardized mortality rate was 8.7 per 100,000 population in the United Kingdom, while in 2015 the age-standardized mortality rate was 6.6 per 100,000 in both the United States and Australia and 7.5 per 100,000 population in Canada.
The surge in Liver Cancer
Sherman told the audience that the reasons for the surge in liver cancer incidence, and the increase in mortality, include infection with hepatitis B and hepatitis C virus, as well as the obesity epidemic.
The obesity epidemic is fueling an epidemic of nonalcoholic fatty liver disease (NAFLD), which can progress to liver cancer, he explained. Even in high-income countries such as the United States, many people are unaware that they have been infected with hepatitis B or C virus; by the time they present with symptoms, it's often too late to offer any curative treatment.
Although new directly acting antiviral drugs (DAA) have transformed the management of hepatitis C effectively curing 95% of all patients who are treated with DAAs the same progress has not been made with hepatitis B. However, there are drugs that can help prevent progression to liver cancer in many patients.
The obesity epidemic that is causing increasing numbers of patients to develop NAFLD is nowhere near under control, Sherman commented. For example, an estimated 20% of the population in developed countries has some level of NAFLD.
Of these, 1 in 10 could progress to cirrhosis, of whom 20% to 30% could develop liver cancer. Indeed, in early June 2018, the Canadian Association for the Study of the Liver published guidelines recommending that individuals born between 1945 and 1975 the baby boomers be tested for hepatitis C.
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I pick Rickie for the win.
We mean he has to win one at some point, right?..
I think you picked him last year too. I like Rickie.
Who's everyone else picking to win it? Last year I picked Rory with Reed as the longshot. Haven't decided yet who I think will won or who'll be a good longshot. But I'll be rooting for Tiger, Reed, Rickie, Kuchar and Finau.
JUST IN: A William Hill in Nevada just took an $85,000 wager on Tiger to win the Masters. At 14-1, pays out $1.19 million if he puts on another green jacket on Sunday.
He has an entire year to come up with a menu and that's the best he can do. Nothing special that I would cut the line for.
Those are real good picks. I might be going with Rose too and Hoffman is a good longshot.
Last year I jokingly made an assumption that since Li was part of the featured groups, it was because they wanted the Chinese fans to use their iphones to watch on the app. Well, well, well. This year he is paired with Tiger which will obviously be a featured or heavily covered group. I think I was right.
A year later this still is a well different story.
Rooting for: Tiger, Reed, Rickie, Kuchar, Finau.
Betting on: DJ(10-1), Rahm(16-1), Koepka(25-1) Matsuyama(35-1), Mitchell(150-1).
I almost went with Kisner. Great choice.
I will pick Jordan Speith to win. Timmy Fleetwood will be all over him though on Sunday.
Course was still a little wet yesterday, but they had the machines getting rid of the water. Forecast is for t-storms on and off the next few days.
What is Koepka doing nutritionally? I don't understand.


Without Warning today Mike's behaviors came full circle.
If you have read my books on Autism and our family you are well aware that we have had some huge hurdles with behaviors. We have had many a dark day with explosive behaviors from Mike. This was a couple of years ago and after a Behaviorist who works primarily with Autistic children intervened we found our groove. That groove first and foremost was Mike, then his dad and me, and his teaching staff.
Mike really made tremendous turns in his behaviors and given the tools to manage them we were on a calmer path. Calmer at home almost always, that I entered a far to comfortable position I realize today.
The end of the school year is fast approaching, only a couple of weeks left. Mike is no different then other students, he is getting anxious for the school year to end. He feels the change in the air and knows that summer is upon us. I have noticed a bit of apprehension the past month or so each morning. He is less then eager to get out of bed and get dressed. He drags a bit more in the morning and is a bit agitated when I put his shoes on and we walk to bus in the morning. Even with this, we did manage to go on with our day, he at school learning and I at home trying to get much needed work done. Summer is soon here and my time to work gets very limited. When summer school break is here, my job is Mike and Mike only. I manage our home, Mike, two Labradors, 4 acres of property ( Jim does the mowing when he can, other wise, I hire someone), a large vegetable garden, swimming lessons, summer school, a older son off to college often still needs mom, and all the daily living that come with a special needs child. I have no free time, I sleep very little. I need to have all my ducks in a row when school break starts. My time for writing is very limited. Mike takes a set of eyes on him at all times.
I am rambling here off course of the premise of my blog here today.
To cut to the chase here- this morning when I got Mike up or I should say attempted to get Mike up this morning our fate was already in motion.
Mike was having no part of going to school today. He was angered and let me know it for an hour and a half strait. He hissed at me, put his hand in the air many times as if to warn me that he might strike. He refused to get dressed. He yelled "no dressed" "no school" on and off for an hour and a half. He was angry about everything. From the breakfast I made ( the same as every day for 7 years ) to the movie I started for him in the dining room for him to eat and watch. Nothing I did was right. If I spoke soft and quiet as not to agitate, he was mad that I spoke soft. When I spoke in a normal tone, he was mad. If I raised my voice as his was so loud, he was just as mad as when I spoke soft.
It was a battle that had no winners. I walked away several times to cool off but he followed me to continue the fight. I had to get him dressed first. I tried all my old tricks, talking to him about it, helping him calmly -- this most often works. Not today. I allowed him time to get dressed on his own. No go there. I also knew this, he had to get dressed and go to school. He was not ill, we had not been up all night so he was tired. He was drawing a line in the sand with me and daring me to cross it. The look in his eyes was "game on". It is a look that I have not seen in a long time but recognized it when he showed it to me. I got him dressed and he fought me every step of the way.
Mike is a fast learner and never, ever forgets anything. If he does something once and has the outcome he wanted, consider it will be used the next time. Breaking a habit or redirecting a behavior is a must at our house. Often it gets worse before it gets better.
After an hour and a half of a tough time I got Mike to the bus. He still did not want to go and he began to cry. His face was so sad and alligator tears were free flowing. The look on the bus drivers face spoke of compassion to him. She was so sad for him and tried as I did to console him. He hugged me and gave me a kiss on the cheek. I held it all in and wished him a good day and said I would take care of his toys while he was gone ( a job he gave me years ago & reminds me I have each and every day when he leaves for school ). I shut the door to the bus, turned and walked away back to the house. As tough as I had to be for him the moment I turned around I broke out in tears. Each step closer to the house the more they flowed. Two eager and happy Labs greeted me when I walked in the door. They also have a routine that they need from me. They get their breakfast when I return from putting Mike on the bus.
I managed to stop my crying to call his teacher. By this time Mike had arrived at school, still crying and they were also questioning what was the matter. We spoke, I told her we had a really tough morning, one we have not had in a very long time. I told her the easy way out was to keep him home and start another problem come Monday. She agreed and said I had done the right thing as hard as it is. I told her I would gladly come get him if they thought it was best. I called later again a few hours later. He had pulled it all together and was doing OK, not great, but OK. He seemed to be having a downer day and just was sad.
I walked into the sun room and just sat on the floor. I cried and cried and the dogs tried their best to comfort me. The sooner I pull it together the sooner they get fed. I sat there almost crippled and weak. I could hardly get up about a half an hour later. I was exhausted. I have not had this type of exhaustion for a long time. A mental drain that can really take me down.
I finally got myself up, attend to the dogs then ventured to Mike's room. His room is always in need of my attention. Mike loves things. Toys, pictures, his drawing, his movies, his books and a zillion other things I seems. He loves to have them where he can see them and touch them. The theory of everything has it place and everything in it's place is not something Mike can do. He wants everything around him and in his sight and within reach. I have to organize it often and put some type of order to it. It is not messy just unbelievably cluttered.
I spent about a half and hour in his room. I have to say he does have some really cool things for a kid. He loves his laptop and had really been busy creating his room of organized kayos. Maybe the issue was he just did not want t leave it today. I know he would rather do what he freely is allowed to do on the weekends, his own thing. He watches movies, is always busy on this computer, he draws, plays with his toys, creates these little pods of special things in a organized way I will never understand. It is his way and we let him do his thing on the weekend. Maybe he just needed the weekend to start this morning and not at the end of the school day. I will never know. I just know it was a horrible morning. I am proud that he managed a good day at school with no further behaviors at school.
He arrived home looking tired, we both were at the same "event" this morning. I was wiped out, I am sure he was also. I kept busy the rest of the day. It is to hard on me when I get so upset to just sit and stew. My mind gets the best of me, I ponder and most often come to the conclusion that I am a horrible mother and rotten wife. Who needs that stuck in their head. Had the morning gone a more positive way I would have thought I was fantastic. I prefer fantastic over failure any day.
It's almost five o'clock in the evening. When I am stressed I clean, my house looks fabulous for the weekend. I also like to organize when I am stressed. I cleaned my desk that was in great need of attention. I cleaned the refrigerator and shopped to stock it. I did laundry and swept the garage. Something I never do, Jim does. I thought of my Mike and had a few tears along the way. Life can be tough, a type of tough if you do not have a Autistic child or a special needs child you will never understand. It's OK, I never understood until I had my Mike.
We survived and will have a enjoyable weekend. I will hope for the best for Monday morning, but will be more prepared should it turn again. Getting to comfortable in any situation most often leads to a bite in the a**. Let's just say, I am sitting on it right now, it is not as sore as it was this morning.
Mike is already in this pj's. He put them on as soon as he got home from school. It is his way of telling me that he has no plans to leave and wants to stay home. He hugged me when he got home. I said I was sorry for the hard morning. He said he was sorry also. He demanded his snack, and has "retired" to his room. He is busy and wishes to be left alone. I went in a bit ago, sat on his bed. He got up, came to me and showed me some of his toys. He then went back to doing his thing and I have respectfully left him alone. As he wishes. He had earned it after the day he has also had.


From the doctors and nurses who refer campers to the medical professionals who volunteer to provide health care at camp, our partners play an integral role in keeping our camp humming and our spirits high.
We are proud to receive support from all of Ohio's Children's hospitals, as well as the Children's Hospital of Pittsburgh. Physicians and staff from these hospitals refer campers and families to Flying Horse Farms and also provide routine health care and supervision for campers at the WellNest, camp's 24-7, onsite health center.


text:
COVID-19 News World
Israel and Bahrain agree to establish full diplomatic ties | USA News
September 11, 2020 South Asian Express	United States
Bahrain and Israel have agreed to establish full diplomatic relations, US President Donald Trump announced Friday, hailing the agreement as "a historic breakthrough".
In a joint statement, the United States, Bahrain and Israel said the agreement was reached after Trump spoke with Israeli Prime Minister Benjamin Netanyahu and Bahrain's King Hamad bin Isa Al Khalifa on Friday.
"This is a historic breakthrough to further peace in the Middle East," the statement reads.
Joint Statement of the United States, the Kingdom of Bahrain, and the State of Israel pic.twitter.com/xMquRkGtpM
The deal comes after Israel and the United Arab Emirates announced a similar agreement last month.
Bahrain will join Israel and the UAE for a signing ceremony at the White House on September 15, Trump told reporters on Friday.
"It's unthinkable that this could happen and so fast," he said about the Israel-Bahrain deal.
In a Hebrew-language statement, Netanyahu said he was "moved" to announce the agreement with Bahrain, which he said "adds to the historic peace with the United Arab Emirates".
Palestinian leaders have criticised Arab states for normalising ties with Israel while it continues its military occupation of Palestinian lands, saying such deals threaten to cement the status quo.
The Palestinian Liberation Organization said Friday that the Bahrain-Israel deal was "another treacherous stab to [the] Palestinian cause".
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