Torticollis is a postural abnormality of the neck leading to head tilt and rotation. It can occur in people of all ages, from the newborn to adults. Classically, torticollis is categorized as congenital or acquired. Congenital muscular torticollis (CMT) is the most common form.
Risk factors include intrauterine malposition and complicated labor and delivery.
The patho-anatomy and pathophysiology behind torticollis is dependent on the primary etiology. In CMT, in the inferior one-third of the affected SCM, a well-circumscribed "tumor" can form, due to a hematoma or a fibroma. As this shrinks the sternocleidomastoid (SCM) shortens, tilting the head toward and rotating the chin away from the affected SCM.
In general, disruption of arterial or neural supply to the SCM or trapezius can result in torticollis.1 For example, during an acute infection, muscle spasms or referred pain can lead to abnormal head positioning.
Another common cause of torticollis is from atlantoaxial rotary subluxation (AARS). Retropharyngeal edema is thought to cause laxity of the atlantoaxial ligaments. Laxity of these ligaments allows for subluxation of the facets of C1 and C2 causing abnormal tilt and rotation of the head.
CMT: By 6 weeks of age.
Older age of onset suggests other acquired conditions.
History of onset: Acute or insidious, trauma, fever, vomiting, neurologic deficits, exposure to medications.
CMT – Right more common, head tilted toward and chin rotated away from affected SCM.
AARS- Head tilted away from and chin rotated toward affected SCM.
Neck extension: Juvenile idiopathic arthritis and AARS.
Posterior fossa tumor: Increased intracranial pressure signs (vomiting, progressive headache, diplopia), balance/coordination problems.
Brachial plexus palsy: Unilateral arm weakness, pain and/or numbness, +/- unilateral ptosis.
Infection: Neck tenderness, fever, irritability, dysphagia, drooling, odynophagia and respiratory distress.
Sandifer syndrome: Regurgitation, vomiting, hematemesis, anorexia, failure to thrive, asthma, chronic cough and/or hoarseness.
Time spent in prone while awake.
Family history on past interventions and response will aid treatment planning.
Inspection: Head/neck posture, pharynx, plagiocephaly, facial dysmorphism, scoliosis, metatarsus adductus, and clubfoot can be associated with CMT.
Palpation: Tenderness or spasms of paracervical and trapezius muscles or spinous processes, thickening or mass of the SCM or trapezius, vertebral deformity, lymph nodes.
Cervical range of motion (ROM): Average passive range of motion in infants is 110° (100° to 120°) rotation and 70° lateral flexion (65° to 75°).11Hip exam: Asymmetry in gluteal folds, ROM, Barlow, Ortolani, Galeazzi maneuvers.
Neurologic: Visual and auditory fixation and tracking, fundi for papilledema, cranial nerves, sensory testing, tone, and reflexes.
Functional strength testing: Consider symmetry and compensatory movements.
Age-appropriate motor skills (rolling, hand dexterity and dominance).
Head held below horizontal line.
Head held on horizontal line.
Head held slightly over horizontal line.
Head held high over horizontal line but <45°.
Head held high over horizontal line and >45°.
Differential blood count +/- rapid streptococcal test if infection suspected.
Karyotype testing for trisomy 21, if indicated based on history of dysmorphism.
Genetic testing (sequence, deletion/duplication analysis) to check for GDF 6 or 3 mutations in Klippel-Feil syndrome, as needed based on history and exam.
Routine MRI in CMT is not recommended.
No clear diagnostic guidelines are available for Sandifer syndrome. Barium swallow test may be considered for suspected cases.
Cranial vault asymmetry index: Difference in cranial diagonal diameter/longer cranial diagonal x 100; significant if >3.5%.
Responds to antireflux medications, upper body elevation when sleeping.
Usually self-limited (resolves by 3 years).
Physicians should inquire about home and social situations that could impact counseling and treatment outcomes. The number of members in the household and their level of understanding, typical daily routine of the caregiver/child and the type of care setting (home versus day care) that is available should be considered.
Custom cranial orthosis for plagiocephaly.
Botulinum toxin Type A injections to SCM or upper trapezius may be considered for those who failed with exercises and TOT collar use.
≥ 6 months of conservative management.
Residual deficits in cervical rotation and lateral flexion >15°.
Bipolar lengthening (distal and proximal).
Acute (< 1 week) and less severe – Soft cervical collar, rest, analgesics +/- diazepam or muscle relaxants.
Severe – Cervical traction, surgery.
Retropharyngeal abscess: Antibiotics (2nd or 3rd generation cephalosporins), NSAIDs, surgery if no improvement within 24 hours.
Primary cervical dystonia: Oral anticholinergics (i.e, trihexyphenidyl), clonazepam and other benzodiazepines, baclofen, botulinum toxin injections, deep brain stimulation for intractable cases.
Sandifer syndrome: Antireflux medication (proton pump inhibitors), head elevation during sleep, surgical fundoplication.
Drug induced torticollis: Treat initially with diphenhydramine.
*No randomized clinical trials (RCT) with long-term follow-up found in the literature.
CMT is ideally managed on an outpatient basis with coordination of care between the treating therapist and pediatric physiatrist. If trial of conservative management fails, discussion with a plastic surgeon or otolaryngologist regarding potential surgical intervention is recommended.
Feeding: Food or bottle presented to side of affected SCM to facilitate neck rotation toward that side.
Positioning: should be placed in a crib in such a way that he is forced to rotate his head to affected SCM and tilt toward unaffected SCM in order to see an interesting object such as a toy mobile.
Encouraging play in prone and facilitating neck extension to allow bilateral SCM muscle stretching.
Turning head to non-favored side while sleeping in supine.
Proper donning of TOT collar.
Factors impacting length of treatment (gender, laterality of involvement and age).
Efficacy of cervical orthosis (TOT collar).
Tomczak K, Rosman NP. Torticollis. Journal of Child Neurology. 2012; 00(0):1-14.
Do T. Congenital muscular torticollis: current concepts and review of treatment. Curr Opin Pediatr. 2006; 18: 26-29.
Subach BR, McLaughlin MR, Albright AL, Pollack IF. Current management of pediatric atlantoaxial rotatory subluxation. Spine. 1998;23:2174-2179.
Freed S, Coulter-O'Berry C. Identification and treatment of congenital muscular torticollis in infants. Journal of Orthotics and Prosthetics. 2004;16(4S):18-23.
Rogers GF, Oh A, Mulliken J. The role of congenital muscular torticollis in the development of deformational plagiocephaly. Plastic and Reconstructive Surgery. 2009;123(2):643-652.
Bredenkamp J, et al. Congenital muscular torticollis: a spectrum of disease. Arch Otolaryngol Head and Neck Surg. 1990;116:212-216.
Canale ST, Griffin DW, Hubbard CN. Congenital muscular torticollis: a long-term follow-up. Journal of Bone and Joint Surgery. 1982;64-A(6):810-816.
Cheng JCY, Wong MWN, Tang SP, et al. Clinical determinants of the outcome of manual stretching in the treatment of congenital muscular torticollis in infants. Journal of Bone and Joint Surgery. 2001;83-A(5): 679-687.
Schertz M, Zuk L, Green D. Long-term neurodevelopmental follow-up of children with congenital muscular torticollis. Journal of Child Neurology. 2012; 00(0):1-7.
Tessmer A, Mooney P, Pelland L. A developmental perspective on congenital muscular torticollis: a critical appraisal of the evidence. Pediatric Physical Therapy. 2010;22:378-383.
Ohman AM, Beckung ER. Reference values for range of motion and muscle function of the neck in infants. Pediatrics Physical Therapy. 2008;20(1):53-58.
Ohman A. The immediate effect of kinesiology taping on muscular imbalance for infants with congenital muscular torticollis. PM&R. 2012;4:504-508.
Lee YT, et al. Clinical features and outcome of physiotherapy in early presenting congenital muscular torticollis with severe fibrosis on ultrasonography: a prospective study. Journal of Pediatric Surgery. 2011;46: 1526-1531.
Kim SN, Shin YB, Kim W, et al. Screening for the coexistence of congenital muscular torticollis and developmental dysplasia of hip. Ann Rehabil Med. 2011;35:485-490.
Haque S, Shafi B, Musa K. Imaging of torticollis in children. RadioGraphics. 2012;32:557-571.
Mortenson P, Steinbok P, Smith D. Deformational plagiocephaly and orthotic treatment: indications and limitations. Childs Nerv Syst. 2012;28:1407-1412.
Celayir A. Congenital muscular torticollis: early and intensive treatment is critical. a prospective study. Pediatr Int. 2000;42:504-507.
van Vlimmeren LA, Helders PJ, van Adrichem LN, Engelbert RH. Torticollis and plagiocephaly in infancy: therapeutic strategies. Pediatric Rehabilitation. 2006;9(1):40-46.
Ohman A, Mardbrink E, Stnsby J, Beckung E. Evaluation of treatment strategies for muscle function in infants with congenital muscular torticollis. Physiotherapy Theory and Practice. 2011;27(7):463-470.
He L, et al. Comparison of 2 dosages of stretching treatment in infants with congenital muscular torticollis. Americal Journal of Physical Medicine & Rehabilitation. 2016; 00: 00-00.
Cottrill-Mosterman S, et al. Orthotic treatment of head tilt in congenital muscular torticollis. Journal of the Association of Children's Orthotic-Prosthetic Clinics. 1987;22:1-3.
Oleszek JL, Chang N, Apkon SD, Wilson PE. Botulinum toxin Type A in the treatment of children with congenital muscular torticollis. Am J Phys Med Rehabil. 2005 84:813-816.
Pelosin E, et al. Kinesiotaping reduces pain and modulates sensory function in patients with focal dystonia: a randomized crossover pilot study. Neurorehabilitation and Neural Repair. 2013; 27(8): 722-731.
Hammond, P. The use of 3D face shape modelling in dysmorphology. Archives of Disease in Childhood. 2007;92(12):1120-1126.
Monreal, J. Functional and aesthetic recovery of congenital muscular torticollis with intramuscular stromal vascular fraction enriched fat grafting. Cureus. 2017; 9(1)e975.
Paola Mendoza, MD, Lainie K. Holman, MD. Torticollis. 09/20/2013.


This bowenite carving of a vase with three mythical animals, Qi Lin, is 5 1/8" high (with fitted hard wood base it is 6" high), 4 ¾" on the widest part and around 2" thick. There is a stamped date on the wood base of Sept. 2004. The carving depicts three Qi Lin playing with ribbons and a ball. It is in excellent condition.
This contemporary bowenite carving of two birds resting on a garden rock is 8 ¾" high (with fitted wood base it is 10" high), 5" wide and 3" thick measured from the bottom and 5" thick measured from the birds' wings. It is in excellent condition.


text:
Best and worst TV series finales, and where does GoT rank? *Spoilers*
By SansaJonRule, May 20 in Entertainment
Martini Sigil
I had no problem with the GoT finale... after those two huge battles, it would have had to be anti climactic... and the fates of all the players were fine with me...
That said, I'll say that Black sails was among my favorite finales.... The Americans was great.... Spartacus was terrific.... The Wire, Halt and Catch Fire, and Breaking Bad were all great... and I'm a total sap who got all misty at the Newsroom finale...
The worst --IMO-- Dexter was embarrassingly atrocious, as was Sons of Anarchy... and Boardwalk Empire was disappointing...
Lady's Ghost
Location:Just Around the River Bend
First elephant in the room... Everyone knows how much I love Sansa. That said, the finale didn't completely suck. But, it is hard to like it. It really is.
The best finale I have ever seen - The Americans. That was masterpiece in acting, writing, directing, music. Everything landed where it should.
As for TBBT, that was absurd. I mean... That Nobel speech reeked of cheap moments.
I remember being thoroughly affected by the slap at the ending of "The Good Wife". "Downton Abbey" finished in a rather mediocre way.
Sense8 finale was an explosion of love. Especially the last scene, followed by the wonderful music by Ludovico Einaudi.
I remember "Six Feet Under" having an interesting montage at the end.
Unfortunately, "Daredevil" ended after 3rd season, so that last episode is now a final one. I liked that.
lady narcissa
aesthetic contemplation
Location:City of Wind
47 minutes ago, Tywin et al. said:
Also, I did not know that HoC was originally a British show. Ya'll should try harder to get things played over here. We clearly love remaking your content, just with poorer outcomes.
It did air here on PBS in 1991. It won an Emmy for writing. I super enjoyed it back then.
Mexal
Cards are only half the battle
Agreed with Black Sails. That ended well. I wish I remembered Blackadder's finale. Love the show, just don't remember how it ended. Some of the most quotable lines in any comedy.
Nictarion
44 minutes ago, Mexal said:
With them going over the top in a suicidal charge.
1 minute ago, Nictarion said:
Ahh yes, in the trenches. I remember now. It's been about 10 years since I've seen it.
Pithy Witticism
Ok so here's what I got written down literally on the back of an envelope in terms of shows mentioned that I've watched and haven't commented on: Friends, Parks and Rec, BB, Wire, Mad Men, Office (American version), Justified, West Wing, Seinfeld. Regarding Frasier, House of Cards, Big Bang Theory, didn't make it to the finale. That goes for HIMYM too I suppose, but I didn't really watch that show in general. Only reason I watch BBT is because I'm an insomniac and it's always on, like Law & Order. Anyway, between those and that of which I've mentioned - Sopranos, LOST, Dexter, GoT, sure I'm forgetting something. Let's do a list:
Oh, there's Weeds too. Def be near the bottom there. Those are the shows I wasted my time with the past 20 years, more or less. Sarah Connor Chronicles and Penny Dreadful too, or course, but other than the zombies that's pretty much it, I think.
Darth Richard II
Dr. Caustic
Eh, I wouldn't call TSCC last episode a finale.
If only man. Just wish Friedman would tell us what he had in mind already.
14 minutes ago, DMC said:
They were THIS close to doing a wrap it up mini series before the rights TO terminator went apeshit.
Yeah. Sucks. Sad face indeed.
Zuzu Bolin
Breaking Bad and The Shield (although the penultimate season of the latter was all filler) and The Wire
Worst:
Charmed, Dexter and Scrubs
GOT somewhere in the middle. My second fav overall but the last season too rushed.
Tywin et al.
I got all this stuff twirling around in my head
Location:Purifying in the Waters of Lake Minnetonka
13 hours ago, lady narcissa said:
Well I was 2-3 then so I get a pass.
It's heartwarming to see everyone agree that Dexter is the worst.
Edited May 22 by Tywin et al.
The Monkey
Best: Six Feet Under, Sopranos, The Leftovers, The Americans, Mad Men
Worst: Game of Thrones, Lost, Vinyl, House of Cards, Heroes
I loved the Breaking Bad finale when I first watched, but in retrospect maybe everything came together a bit too neatly for it to be one of the all-time bests. I feel the opposite with the Deadwood finale (if we ignore the upcoming movie); felt at first extremely disappointed about the cancellation which meant the show wouldn't get the proper send-off. However, on re-watches I enjoy the season three ending quite a bit. Al muttering to himself "He want me to tell him something pretty...." is a fairly great line to go out on.
Edited May 22 by The Monkey
4 minutes ago, The Monkey said:
Best: Six Feet Under, Sopranos, The Leftovers, The Americans
Vinyl was such a disappointment overall.
The Mother of The Others
It's up there with Ally McBeal and Grey's Anatomy.
The way to look at this is the Game of Thrones guys found a way to remain good friends of George- - - by finishing the show this way they didn't step on his finale or overshadow it or look competitive with his genius. The show's end was like an advertisement for reading the real conclusion to get satisfaction , to get the nutrients missing from a TV diet.
red snow
Prince of Procrastination
Location:Bristol, UK
18 hours ago, Martini Sigil said:
Spartacus is another one i forgot. It was also excellent
polishgenius
I had no problem with the GoT finale... after those two huge battles, it would have had to be anti climactic
I've got no problem with people liking the finale obviously even if I find that surprising but I've gotta say I don't get this sort of reasoning. In the hands of a good writer the wind down after a big climax doesn't have to be anti-clmactic at all, and in this case even moreso coz there was still plenty of dramatic stuff left to do.
Dragon in the North
23 hours ago, Risto said:
I, for one, loved the GOT finale and didn't find it hard to like at all. After The Shield, it's my second favorite finale.
The Americans had an incredible finale as well, though I had one or two issues with it. I agree the music and acting was outstanding. I'm so glad the writer/writers won an Emmy for it.
Edited May 22 by Dragon in the North
Go To Topic Listing Entertainment

redpajama_set_name: RedPajamaCommonCrawl


If you're interested turning your garbage into compost- to support the planet and/or your plants- there is a very simple option. Before you buy worms (a much faster method) or build a compost bin, you can take a baby step into composting.
You simply take a large plastic bag and poke holes in it, throw in your organic waste- both browns (i.e. dead leaves) and greens (i.e. grass clippings or kitchen waste)- and wait a month or two. Stir once in awhile. We at faircompanies decided to give it a try on our city apartment terrace.
In this video, we open the bag three months into our experiment.


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The Army is testing a 'guaranteed hit' smart scope for its rifles
Via www.popularmechanics.com:
The U.S. Army is evaluating a scope that won't let the user fire his or her rifle unless the shot is guaranteed. The SMASH scope is the product of Smart Shooter Ltd., an Israeli company, and could go on the Army's upcoming replacements for the M4 carbine and M249 squad automatic weapon. The scope, or one like it, will eventually go on the Army's next generation squad automatic weapons.
Military.com tried out the SMASH system at the SHOT Show 2020 in Las Vegas, Nevada. Smart Shooter teamed up with Sig Sauer to compete in the Army's Next Generation Squad Weapon Fire Control program. NGSW-FC's goal is to field a smart optic to go on the service's Next-Generation Squad Weapon (NGSW). NGSW will choose a new 6.8-millimeter assault rifle and squad automatic weapon to replace the Army's M4 carbine and M249 squad automatic weapon.
Current U.S. Army carbines and squad automatic weapons use a variety of red dot or other sights that project a reticle or crosshairs on target. The soldier must still line up the sights with the target while computing ballistic drop and the effects of wind on bullet flight.
All of this is a lot to compute, especially in combat. Fortunately the problem was solved in the 1970s when ballistic computers on main battle tanks became smart enough to automatically calculate this information. This revolutionized tank gun accuracy, making tanks accurate even on the move. Thanks to Moore's Law, those computers have finally become small enough to mount on a rifle.
SMASH's system incorporates night vision, magnification, and target detection and tracking. According to Military.com, the system uses a sight that clips above the barrel and a special pistol grip. Pressing a button next to the grip automatically detects possible targets, projecting red boxes around them in the sight's field of view. The shooter then depresses the trigger and holds it down. The weapon will fire when the barrel is properly aligned with the target, causing a "guaranteed hit." The auto tracker system can be disabled for other types of shooting.
The Army is testing a number of fire control systems as part of NGSW-FC, and plans to field the first new carbines and squad automatic weapons to combat units in 2023.
Disabled Iraq veteran faces 5 years in prison for prescribed medical marijuana
Man Threatens to 'Shoot up' Fort Hood in Retaliation for Vanessa Guillen's Murder


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Friedrich Wilhelm Ludwig Bornemann (født 28. marts 1798 i Berlin, død 28. januar 1864 sammesteds) var en tysk retslærd. Han var søn af Johann Wilhelm Bornemann.

Bornemann blev departementschef i justitsministeriet i Berlin 1844, justitsminister 1848, præsident for overtribunalet i Berlin, kronsyndikus, medlem af herrehuset. Bornemann, typen på en preussisk bureaukrat, med en sådans fortrin og fejl, har fortjenesten af at have givet den første egentlige videnskabelige bearbejdelse af den preussiske landret, således i hans hovedværk Systematische Darstellung des preuszischen Civilrechts, mit Benutzung der Materialien des allgemeinen Landrechts (I—VI, 1834—38, 2. oplag 1842—45). Af Bornemanns øvrige, ikke omfangsrige forfatterskab kan fremhæves: Von Rechtsgeschäften überhaupt und
von Verträgen insbesondere, nach dem preuszischen Rechte (1825, 2. oplag 1833).

Kilder

Jurister fra Tyskland
Faglitterære forfattere fra Tyskland
Tysksprogede forfattere
Tyskere i 1800-tallet
Personer fra Berlin

redpajama_set_name: RedPajamaWikipedia


Protect your valuables with Liberty's entry level safes - Liberty's Centurion Series!
Available in 12, 18 and 24 gun safe models, each Centurion is MADE IN THE USA and includes Liberty's lifetime warranty.
When it comes to saving money, Centurion safes are a great way to go providing solid protection and basic fire protection of your valuables.
Made in USA/&/Carries Lifetime Warranty I'm Well Pleased & Think U Will be Too.
Excellent safe with Mechinical lock.
We found this safe at Orscheln Farm & Home on a "Fathers day sale". We had been looking for 6-8 Mo for a good 24 gun safe with a quality mechanical lock. I have worked in electronics & broadcast radio for years and did not want a surface mount devices circuit board lock. I have seem many small motors & solenoids fail in very expensive equipment so the dial lock was very welcome on this 24 gun safe. The quality seems very good. Liberty does not provide all the "bells & whistles" of the Chinese competitors like included door pockets, and a bolt down kit. I feel getting a better safe makes up for these omissions which can be purchased separately. I like the unique flat side plate locks. All in all I think it will protect against most residential crime & organize your gun collection. Hardened criminals (given time) with the right tools can break into anyone's safe. Luckily they are quite rare. We would recommend everyone looking for a 24 gun safe consider the Liberty models.


Looking for native English speaker to teach kids. Americans or Canadians preferred. Teaching experience preferred. Must have TEFL certificate. Must have outgoing personality and be good with kids.
This is a full-time job with a fantastic salary - 20000 RMB per month. The primary school is situated in Tongzilin, a nice area with very convenient transport to the rest of Chen gdu.
Sichuan Education Association for International Exchange (SEAIE), is a government-sponsored organization specializing in placing foreign teachers in Sichuan, southwest China. We have a proud history and proven track record of delivering foreign teachers. We hope to enrich people´s lives through education and promote c ultural exchanges between East and West.
We are the most secure English teaching jobs provider in the province.


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De Zweedse rijksweg 94 is een verbindingsweg tussen twee voornamelijk Zweedse Europese wegen, de E45 in het binnenland en de E4 langs de kust van de Botnische Golf. De weg is circa 154 kilometer lang.

Diverse delen van de weg hadden in het verleden andere nummers.

Plaatsen langs de weg
 Luleå
 Antnäs
 Alvik
 Klöverträsk
 Pålsträsk
 Älvsbyn
 Korsträsk
 Vistträsk
 Lauker
 Arvidsjaur

Knooppunten
 Riksväg 97: start gezamenlijk tracé in Luleå (begin)
 Riksväg 97: einde gezamenlijk tracé, E4: start gezamenlijk tracé, E10, bij Luleå
 E4: einde gezamenlijk tracé, bij Antnäs
 Länsväg 356: start gezamenlijk tracé
 Länsväg 356: einde gezamenlijk tracé, en Länsväg 374 bij Älvsbyn
 Riksväg 95 bij Arvidsjaur (einde)

94
Riksvag 94


text:
Microsoft word - 2013_cacs_symposium_program_long061113.docx
2013 Tri-State CACS Annual Symposium
Facing the Global Chemical Enterprise
The Department of Medicinal Chemistry Ernest Mario School of Pharmacy, Rutgers University 8:30 am – 4:00 pm Saturday, June 22, 2013 Busch Campus Center
604 Bartholomew Rd
www.tristatecacs.org
Job Fair and Career Consultation Abstracts & Speaker Biosketches Morning session Afternoon session Tri-State CACS Officers Website: http://www.tristatecacs.org/ Email: [email protected]
Welcome to the 2013 Tri-State CACS Annual Symposium!
On behalf of the Tri-State CACS Board, we would like to express our sincerest appreciation to our sponsors and
volunteers for their support and contributions to this symposium and to our organization.
We are living in a world that is also changing constantly. The American chemical and pharmaceutical
industries as a whole and the Chinese-American chemical professionals in particular are presented with
unprecedented challenges and opportunities in this rapidly shifting global environment. For a business to
survive and to thrive, it must constantly innovate and reinvent itself, locally and globally. Chemical and
pharmaceutical businesses are no exceptions. For each participant in the chemistry enterprise, one must realize
that he/she needs to constantly sharpen his/her existing skills and promptly master new skills in order to
succeed.
Again, we are very pleased to have a group of prominent leaders from chemical, pharmaceutical, educational,
legal organizations as well as small businesses to join us at this year's symposium. We are extremely pleased to
have the first Chinese American President of the American Chemical Society, Dr. Marinda Li Wu, join us this
year. These leaders will share their wisdom and perspectives on "New Challenges and Opportunities Facing
the Global Chemical Enterprise", that will inspire, educate and entertain our curious minds, no matter which
branch of the chemical enterprise we are interested in. We thank all of the speakers for taking the time to share
their visions about the future growth drivers and their leadership experience as well as to provide career advices.
The presentations will be accompanied by a vendor exhibition, job search consultation, advertisement of new
job openings from both local and overseas companies. In addition, this symposium serves as an excellent
networking opportunity for chemical professionals to meet and interact with people from diverse chemical
We thank you for making this symposium part of your weekend and for making CACS a more valuable
professional organization to all of us.
Wendy Zhong, Ph.D. Mark Zhen, Ph.D. Fanwen Zeng, Ph.D. Immediate Past-President Website: http://www.tristatecacs.org/ Email: [email protected]
Registration / Breakfast & Coffee Morning Session
(Session Chairs: Drs. Shel Zhang and Min Liu) Globalized Chemistry Enterprise and Global Challenges
Opening Remarks, Wendy Zhong, Ph.D., 2013 President, Tri-State CACS
Marinda Li Wu, Ph.D., 2013 President, American Chemical Society
Partners for Progress and Prosperity Brian Maurer, Global R&D Director, the Dow Chemical Company and Chairman of the Chemistry
Council of New Jersey
A New Renaissance for the Chemical Industry
Zhihong Ge, Ph.D., Executive Director of Global Analytical Chemistry, Merck Research Laboratory
Analytical Technology to Enable Drug Discovery and Development
Vendor Show, Coffee Break & Networking
Vivian Yao, Worldwide Vice President of Human Resources, Global Surgery Innovation, Johnson &
Career Development and Talent Management in Medical Devices Tian Yang, Ph.D., Director of Preclinical Drug Evaluation, Global Alliance for Tuberculosis Drug
Discovery and Development
Drug Safety Challenges in Drug Discovery –Examples in Tuberculosis Drug Discovery and Treatment Lunch Break (on site) Afternoon Session
(Session Chairs: Drs. Mark Zhen and Peng Zhang) Sharpen Your Saw for Global Opportunities
Hai-Lung Dai, Ph.D., Laura H. Carnell Professor of Chemistry, Provost and Sr. Vice President for
International Affairs, Temple University
New Paradigms for Educating Chemistry Professionals in a Globalized World Fang Liu, Ph.D., Shareholder and Attorney at Law, Buchanan Ingersoll & Rooney, PC
Patent Attorney – Alternative Career Opportunity Vendor Show, Coffee / Ice Cream Break / Networking
Changxi Miao, Ph.D., Vice Chief Engineer, Shanghai Research Institute of Petrochemical
Technology, SINOPEC
Recent Advance in Technologies of Coal to Chemicals Developed by SINOPEC
Gautam Saxena, President & CEO, Integrated Analysis Inc.
Private Cloud Informatics Technology for Mass Spectrometry: 100x Faster, 30% More Identifications, Zero Hardware and
Closing Remarks, Mark Zhen, Ph.D., 2013 President-Elect, Tri-State CACS
Website: http://www.tristatecacs.org/ Email: [email protected]
(Session Chairs: Drs. Jian Wang and Min Liu) The Dow Chemical Company
http://www.dow.com Therm Fisher Scientific
http://www.agilent.com http://www.waters.com Primera Analytical Solutions
http://www.jnj.com Analytical Sales
SINOPEC (Shanghai)
Job Fair and Career Consultation
(Coordinators: Drs. Lijuan Wang and Fanwen Zeng) Job fair will connect job seekers with hiring managers or job postings from companies in the US and China,
such as SINOPEC Shanghai Research Institute of Petrochemical Technology, Shimadzu Scientific Instruments,
Johnson and Johnson and The Dow Chemical Company. Please come to the booth area for more details.
Mr. Bill Suits, ACS career consultant, will provide free consultation about how to get a job, keep a job and build a successful career. Ms. Kathryn Moore and Dr. Jianxin Zhang from USDA will have a general career consultation on how to search and apply for job opportunities at government agencies such as USDA. Website: http://www.tristatecacs.org/ Email: [email protected]
Symposium Chair
Fanwen Zeng, Wendy Zhong, Lijuan Wang, Shel Zhang, Min Liu, Yingchun Lu, Mark Zhen, Yijun Lu, Rachel Xiaoqiu Wu, Peng Vendor Show
Jian Wang, Min Liu, Fanwen Zeng, Yijun Lu, Yingchun Lu Job Fair/
Lijuan Wang, Fanwen Zeng Baoqing Ma, Fangbiao Li, Sam Xiang Zhu, Noah & Maria Li, Amber Zhen, Cindy & Patrick Ma, George Zeng, Lorraine Zhang Food/Beverage Services
Longqin Hu, Baoqing Ma, Yabin Lei, Sam Xiang Zhu Photography
Hongwei Shen, Fanwen Zeng Jack Zhigang Li, Hongwei Shen, Yabin Lei, Honghong Li Website: http://www.tristatecacs.org/ Email: [email protected]
Abstracts & Speaker Biosketches
Morning Session
"Partners for Progress and Prosperity"
Abstract: A major challenge facing the global chemistry enterprise is the need to promote a deeper appreciation
and understanding from our policy makers and the general public for the wonderful benefits that chemistry
contributes to everyday life. A brief overview of the American Chemical Society (ACS) and highlights of
various public outreach programs will be presented. My personal professional journey and experiences with
successful ways to show the general public the valuable contributions to society resulting from chemistry and
science will be shared. The audience should gain some ideas of how to effectively share enthusiasm for
chemistry and its benefits with young students and the general public through the ACS vision: "Improving
people's lives through the transforming power of chemistry." I will conclude by discussing highlights of my
ACS Presidential initiatives for 2013 and welcome your feedback and ideas.
Bio: Dr. Marinda Li Wu received a B.S. cum laude with Distinction in Chemistry from
The Ohio State University in 1971 and a Ph.D. in Inorganic Chemistry from the
University of Illinois in 1976. With over thirty years of experience working in the
chemical industry, she enjoyed many years working for Dow Chemical R&D as well as
Dow Plastics Marketing forging partnerships between industry, education, government
and communities. Dr. Wu also has entrepreneurial experience with various small
chemical companies and startups including "Science is Fun!" which she founded to
engage young students in the excitement of science and enhance public awareness of the
importance of supporting and improving science education.
As an ACS member for over forty years, Dr. Wu has served in many leadership roles at
both the local and national levels for the American Chemical Society. Dr. Wu was elected
to the ACS Board of Directors and served as Director-at-Large since 2006. In 2011, she was elected to the
Presidential succession of the American Chemical Society. As ACS President-Elect for 2012, she was invited to
give plenary lectures worldwide and made an honorary member of the Romanian Chemical Society and Polish
Chemical Society. She serves as ACS President in 2013 and Immediate Past President in 2014.
Dr. Wu serves on the University of Illinois Chemistry Alumni Advisory Board, the International Advisory Board
for the 45th IUPAC World Chemistry Congress 2015, the ACRICE-1 (1st African Conference on Research in
Chemistry Education) International Advisory Board, and the Board of Directors for the Chinese-American
Chemical Society. She holds 7 U.S. Patents and has published a polymer textbook chapter and numerous articles in
a variety of journals and magazines over the years.
Brian Maurer, Global R&D Director – Dow Chemical and Chairman of the Chemistry Council of New Jersey
"A New Renaissance for the Chemical Industry"
Abstract: Not so long ago, many economists, policymakers, and business leaders had written off chemical
manufacturing in this nation and believed the sector's decline was irreversible. However, recent shale gas
developments have created a renewed optimism for the business of chemistry. This presentation will review the
Website: http://www.tristatecacs.org/ Email: [email protected] opportunities and challenges for a chemical manufacturing renaissance in the United States as well as the state of New Jersey.
Bio: Brian R. Maurer is a global Sr. R&D Director for the Performance Plastics
division of the Dow Chemical Company. During his 30+ years with Dow Chemical,
more than half of his career was spent in three different global R&D Director roles.
Most recently he served as Sr. R&D Director of Dow's Electrical &
Telecommunications business. His global DE&T R&D organization developed novel
solutions for the effective transmission and distribution of power, video, voice and data.
Brian also served as Sr. R&D Director for Dow's Water Soluble Polymer business which
developed new technologies for pharmaceutical, personal care, food, construction
chemical, and paint applications. Finally, he served as Sr. R&D Director of Dow
Automotive which successfully developed plastic, fluid, film and foam technologies
used in auto interior and exterior applications.
From an external perspective, Brian serves as chairman of the Chemistry Council of New Jersey. The
CCNJ supports 55,000 employees, generates $25-30B in annual revenue, and is comprised of 125
member companies from across the state of NJ. From an academic perspective, he serves on technical
advisory boards at Georgia Tech (National Electric Energy Testing Research Applications Center),
Rutgers University (Department of Chemistry & Chemical Biology) and Central Michigan University
(College of Science & Technology). He is currently a member of the Society of Plastics Engineers, the
Society of Automotive Engineers, and the American Chemical Society.
Brian is a chemistry graduate of Central Michigan University and has completed executive MBA training at Thunderbird University in Glendale, Arizona as well as IMD in Lausanne, Switzerland. He is the author of ten patents/applications, was a recipient of Dow's "Inventor of the Year Award," received nine external innovation awards, and received Dow's "Genesis Award" for excellence in people leadership. Vivian Yao, Worldwide Vice President of Human Resources, Global Surgery Innovation, Johnson & Johnson
"Career Development and Talent Management in Medical Devices"
Vivian (Ying) Yao is the Worldwide Vice President of Human Resources for
Ethicon's Global Surgery Innovation Team. She drives the innovation strategic
capability development and talent agenda for the $12 billon global businesses. Vivian
also serves on the Johnson & Johnson Human Resources Council, as well as, the
MD&D Global Human Resources Leadership team.
Vivian joined Johnson & Johnson from General Electric (GE) where she served as the
Organization and Staffing Leader responsible for global talent development across the
company's commercial and communications functions, representing roughly 40,000
employees. Working in support of GE's executive commercial leadership team,
Vivian was responsible for building the commercial capabilities and global talent
pipeline in support of the GE platforms of ecomagination, devoted to reducing environmental impact with new technologies, and healthymagination, focused on achieving sustainable health through innovation. During her ten- year career at GE, Vivian served in many progressive HR generalist and business partner roles, including partner to GE Healthcare's Life Science Americas business. She has served as the architect of new commercial Website: http://www.tristatecacs.org/ Email: [email protected] operating models, business integrations and new capability builds globally and is well recognized as a leader
who drives employee engagement, performance and results.
Prior to joining GE, Vivian served as a consultant at Chicago-based Towers Perrin and as an HR consultant at
IBM's Storage System Division in San Jose, CA.
Vivian spent the early years of her career as an HR Partner for General Motors Asia working in China to
attract, develop and retain high-performing and high-potential employees.
"Analytical Technology to Enable Drug Discovery and Development"
Abstract: The increasing pace of drug discovery and development in recent years demands more efficient and
innovative approaches for pharmaceutical research. Many emerging trends at Merck and across the industry
such as platform technologies and novel drug delivery techniques as well as new regulatory requirements have
posed new challenges for analytical science. In this presentation, examples of recent advances in analytical
technologies to enable drug discovery and development will be highlighted.
Bio: Dr. Zhihong Ge is an Executive Director and a leader of the global Analytical
Chemistry organization which spans Analytical and Physical Chemistry disciplines at
Merck Research Laboratories. The group is responsible for providing critical
measurement and analysis capabilities to support small molecule, peptide, siRNA,
experimental medicine, and Product Value Extension (PVE) pipeline from Discovery to
Phase IIB. This includes the development of analytical methods and specifications for
release of drug substance for safety and clinical studies, as well as for control of the
synthetic process through raw material analysis and in-process testing. She also
provides analytical data and information for Investigational New Drug (IND) filings.
Zhihong received her B.S. from Beijing University in 1987 and joined Merck in
1992 after completing her PhD at University of Washington. During her tenure at Merck, Zhihong has
participated in many development programs including marketed products Crixivan, Arcoxia and Isentress. In
1999, she created a Process Analytical Technology (PAT) group within the Process R&D and since then
introduced numerous "first kind to Merck" PAT technologies to monitor, optimize and control drug substance
synthetic processes.
Zhihong has been an author or co-author on more than 30 publications. She was a member of PhRMA PAT
Expert Working Group and PhRMA LD KIT (Limited Duration Key Issue Team) on Genotoxic Impurities.
Currently she participates in PhRMA ICH M7 Expert Working Group and International Consortium for
Innovation and Quality (IQ) Specification team.
Tian Yang, Ph.D., Director of Preclinical Drug Evaluation, Global Alliance for Tuberculosis Drug Discovery
and Development.
"Drug Safety Challenges in Drug Discovery – Examples in TB Drug Discovery and Treatment"
Abstract: Decreasing the high attrition rate in drug discovery and development process is a primary goal of the
pharmaceutical industry. Drug candidates failed to be further development in clinical is mainly due to lack of
efficacy, adverse drug effect, poor bioavailability, and business/market. Thus one of the main challenges in drug
discovery and development is to define an appropriate balance between drug efficacy and potential adverse
effects as early as possible in order to reduce safety-related attrition, particularly in the more expensive late
Website: http://www.tristatecacs.org/ Email: [email protected] stages of clinical development. A number of in vitro assays have been developed to guide discovery lead optimization to reduce drug safety liabilities including in vitro pharmacological profiling, cell based toxicity, and screening of ion channels. The presentation will discuss in vitro toxicological 'hit' and optimization strategies. Examples will be given from tuberculosis drug discovery and development.
Bio: Dr. Tian J Yang is Director of Preclinical Drug Evaluation at Global Alliance for
Tuberculosis Drug Discovery and Development. He is responsible for DMPK/Tox in
drug candidate optimization and preclinical development. Prior to joining TB Alliance,
Dr. Yang spent 5 years at Roche Nutley, served as head of enzymology group and then
head of drug metabolism group. Before working at Roche, Dr. Yang worked as a
research scientist at DuPont Pharma and BMS for 8 years in optimization of drug
candidate ADME properties and preclinical development. Dr. Yang received his Ph.D.
in pharmacology focused on liver injury and protection from Peking Union Medical
College in 1991. Following two years of postdoctoral research on CNS drug discovery
at the Uniformed Services University of Health Sciences at Bethesda, MD, he joined the
NCI/NIH as a staff fellow and senior staff fellow working on CYP monoclonal antibody
preparation and phenotype of drug and carcinogen metabolism. Website: http://www.tristatecacs.org/ Email: [email protected] Afternoon Session
Hai-Lung Dai, Laura H. Carnell Professor of Chemistry, Provost and Sr. Vice President for International
Affairs, Temple University
"New Paradigms for Educating Chemistry Professionals in a Globalized World"
Abstract: In today's ever more collaborative environment for education and research in a globalized world,
what lessons can we take from other societies and what new avenues can we explore in educating future
generations of chemists, or for that matter, scientists? The possibilities range from new paradigms for educating
secondary science teachers, to collaborative dual degree programs that enhance students' professional
capabilities, to dual doctoral degrees that both enrich the student's experience as well as the participating
institutions' ability to conduct research. Teacher education programs, dual bachelor-master degrees program,
and bilateral doctoral degree programs established at the University of Pennsylvania and Temple University will
be highlighted as examples.
Hai-Lung Dai is Provost and Senior Vice President for Academic Affairs, Laura H.
Carnell Professor of Chemistry, and also continuing to serve as the Senior Vice Provost
for International Affairs at Temple University.
A graduate of National Taiwan University, he holds a PhD from the University of California at Berkeley, and was a postdoctoral fellow at the Massachusetts Institute of Technology. In 1984 he joined as faculty at the University of Pennsylvania where he was Chair of the Chemistry Department, funding Director of the Penn Science Teacher Institute, and the Hirschmann-Makineni Professor of Chemistry. During his two-term chairmanship, the Penn Chemistry Department ranked as high as #6 in the nation in terms of sponsored research funding. The chemistry teacher training programs that he created was cited by the National Academies as a model for content preparation for science teachers and he was invited to testify in the US Senate in 2006 on a HR bill aimed at science teacher training. In 2007, he moved to Temple University as Dean of the College of Science and Technology. As Senior Vice Provost for International Affairs since 2010, he oversees Education Abroad, which manages study abroad and Temple's overseas campus in Tokyo and Rome; International Programs, which facilitates and manages partnerships with foreign institutions and collaborative educational programs; International Students and Scholars Services; and International Student Recruiting and Admission. Under his leadership, Temple has created new dual bachelor's-master's degree, collaborative bachelor degree programs, and dual PhD degree programs for international students with partner universities in Asia and Europe and a liaison office in Beijing coordinating collaborative programs and student recruiting; vastly expanded Temple's partnerships all over the world; and raised awareness of globalization within Temple's campus. In Feb. of 2013, Dai was appointed to the position of Provost and Senior Vice President for Academic Affairs. In this capacity he oversees a $600 million annual budget that supports the academic functions of 17 colleges and schools. Within the short period after assuming this responsibility, he led the effort to design and implement a new scholarship and financial aid plan that vastly expanded the offerings designed for improving student quality and reducing student debt, started investment in a new faculty recruiting campaign, and launched a series of effort aimed at improving the University's education quality and reputation. Website: http://www.tristatecacs.org/ Email: [email protected]
Fang Liu, Ph.D., Attorney at Law, Shareholder, Buchanan Ingersoll & Rooney PC
"Patent Attorney – Alternative Career Opportunity"
A daily life of a patent attorney will be discussed as well as how to become a patent attorney and basic patent
application filing requirements.
Bio: Fang Liu is a patent attorney with the firm Buchanan Ingersoll & Rooney PC.
Ms. Liu's practice includes U.S. and foreign patent preparation and prosecution, and
patentability, validity and non-infringement opinions in matters pertaining to a wide
array of organic/inorganic chemical arts, such as pharmaceutical chemistry, polymer
chemistry, petroleum chemistry, nanotechnology, photographic and lithographic
chemistry, material chemistry, agricultural chemistry, food additives, and coating
compositions.
Before joining Buchanan, Fang was a patent attorney with one of the largest
intellectual property boutique firms in Washington, D.C. Prior to her legal career,
she worked for more than 10 years in research and development as a research
associate and teaching assistant at several U.S. universities.
Fang is also a published author who has contributed to a number of articles and books on chemistry-related
topics.
While pursuing her Ph.D. in organic chemistry at Purdue University, she studied under Ei-ichi Negishi, the
Nobel Prize-winning scientist. Fang's postdoctoral adviser, Marye Anne Fox, is a recipient of the National
Medal of Science, the highest honor bestowed by the United States government on scientists, engineers and
inventors.
Changxi Miao, Ph.D., Vice Chief Engineer, SINOPEC Shanghai Research Institute of Petrochemical
"Recent Advance in Technologies of Coal to Chemicals Developed by SINOPEC"
Coal to chemicals technologies have made a breakthrough in recent years in China, mainly driven by high crude oil price and strong market demand for chemicals. The latest advances in coal to chemicals technologies developed by SINOPEC were reviewed. SINOPEC methanol to olefins (S-MTO) technology has been commercialized successfully in 2011. Industrial demo tests of SINOPEC methanol
to propylene (S-MTP), syngas to ethylene glycol, methanol to xylene (MTX) and SNG
processes are being carried out. A great progress has been made in the research area of
methanol to aromatics (MTA), syngas to olefins (GTO) and acetic acid hydrogenation
technology etc. in lab scale.
Bio: Changxi Miao received his Ph.D. degree in Physical Chemistry from Fudan
University in China in 1996. After graduation, he joined SINOPEC as a research staff. In
2002, he worked at University of California, Berkeley as a visiting scholar. In 2003, he
Website: http://www.tristatecacs.org/ Email: [email protected] was named Professor. Now he is Vice Chief Engineer of SINOPEC SRIPT and in charge of the R&D of styrene catalyst and technology. Dr. Miao has applied more than 120 patents. He is the author of more than 60 scientific papers in the fields of heterogeneous catalysis and chemical technology. Gautam Saxena, President & CEO, Integrated Analysis Inc.
"Private Cloud Informatics Technology for Mass Spectrometry: 100x Faster, 30% More Identifications,
Zero Hardware and Global Collaborations"
In the world of mass spectrometry, bioinformatics has been argued to be one of the biggest bottlenecks for
effective use of the mounds of generated MS data. A few of the biggest labs have invested multiple years and
millions of dollars building custom, proprietary internal informatics solution to address these informatics needs.
Even back in 2008, we wondered if there was a better way. Many years ago, a startup company that was spun
off from the University of Maryland approached us. They wanted to know if we could develop an informatics
solution for their MS needs. Rather than trying to build a custom solution for a single client, we decided to
approach the problem from the perspective of developing a more general, universally applicable MS informatics
product using all the knowledge we had gained in developing bid data solutions for clients in other fields.
We will share the story of the initial customer needs in 2008, how Johns Hopkins University (JHU) became
ultimately our key client from 2008 to the present day, our missteps along the way (both business and
technical), and ultimately the five major problems we discovered that almost all MS informatics suffered from:
1) securely and robustly storing massive amounts of MS data; 2) processing the MS data 100x faster compared
to traditional approaches by using private cloud technology; 3) enabling true global accessibility and
collaborations; 4) integrating disjointed MS informatics processes; and 5) eliminating/reducing the hidden costs
and complexities of these so-called "enterprise informatics" solutions.
We will conclude with the current state of affairs at JHU, in particular focusing on the exciting companies
-- with reputable venture capital funding -- that the JHU PIs have started based on the putative biomarkers
identified using mass spectrometry coupled with the above-referenced informatics solution.
Bio: Gautam Saxena graduated with a degree in Electrical and Computer
Engineering (1999) from McGill University (Montreal, Canada). During his studies,
he founded two companies (a software consulting company and a tax company, the
latter of which was successfully sold.) From 2000 to 2002, he worked as the
"National Solutions Architect" and then the "Global Solutions Architect" for one of
the fastest growing and successful Silicon Valley companies, Informatica Inc. In
those roles, he worked with Informatica's largest clients to outline solutions for their
big data problems. In 2002, he founded Knights Consulting, which for the first six
years was a boutique consulting company focusing on big data projects for Global
100 clients such as National Institute of Health, Oracle, Sun Microsystems, Johns Hopkins University, Phoenix Children's Hospital, Thomson Prometric, and Business Objects. In 2008, he renamed Knights Consulting to Integrated Analysis and began development of a software service which was focused on MS-based informatics. Website: http://www.tristatecacs.org/ Email: [email protected]
Bill Suits ACS Career Consultant
Bill Suits serves as a volunteer ACS Career Consultant who has assisted over
2000 in transition in the last twenty years. He continues to host monthly Careers
in Transition meeting in North Jersey. He served as Chair of the North Jersey
section and Chair of the inaugural MARM Board of directors. He continues as a
Councilor for North Jersey and has served on LSAC, CEPA and PR and
Communications committees nationally. After Graduating from the University of
Wisconsin where he played in the Rosebowl, he worked with Chromatography
suppliers in sales, marketing and application roles.
Website: http://www.tristatecacs.org/ Email: [email protected] Tri-State CACS Officers (2013)
Wendy Wenqing Zhong [email protected] Mark Yueqian Zhen [email protected] Immediate Past-President Fanwen Zeng Secretary Sunny Xuhong Wang [email protected] Rachel Xiaoqiu Wu [email protected]
Lei, Yabin; Li, Jack Zhigang; Liu, Min; Lu, Yingchun; Ma, Baoqing; Shen,
Hongwei; Wang, Jian; Wang, Lijuan; Wang, Kun; Zeng, Fanwen; Zhen,
Yueqian (Mark); Zhang, Peng; Zhang, Shel; Zhong, Wendy; Zhou, Boli;
Zhu, Xiang (Sam).
Cao, Guang; Cao, Ping; Chang, David Y.; Chen, Chien-Kuang; Chen, Guodong; Chen, K. Y.; Chen, Meng-Hsin; Chen, Shaoqing; Cheung, Hong-Son; Chiang, Joseph; Duh, How-Yunn; Guo, Paul; Ho, Teh C.; Hsieh, Tony Y.; Hu, Kevin; Hu, Longqin; Lan, Shih-Jung; Li, Ge; Ma, Wuping; Qian, Kuangnan; Shi, Shawn; Shih, Neng-Yang; Siew, Ernest; Su, Heng; Sun, Yongkui; Tan, Hock; Wang, Stephen; Wang, Sunny Xuhong; Wang, Yuguang; Wu, Xiaoqiu; Xia, Tianhui; Yeh, Lisa; Zhang, Donglu; Duxi Zhang, Zhang, Hongjian; Zhang, Xumu Website: http://www.tristatecacs.org/ Email: [email protected] Website: http://www.tristatecacs.org/ Email: [email protected] Sponsors
Tri-State CACS gratefully acknowledges the following sponsors for their support of Tri-State CACS and this symposium: Department of Medicinal Chemistry Ernest Mario School of Pharmacy Rutgers University Website: http://www.tristatecacs.org/ Email: [email protected]
Source: http://tristatecacs.org/Conferences/13AS/Program_.pdf
mstem.gov.jm
WEEKLY GLOBAL ENERGY Markets SNAPSHOT September 1 – September 5, 2014 News you missed during the week… St Vincent Geothermal Power Plant Could Be Operational By 2018 St. Vincent and the Grenadines Prime Minister, Dr. Ralph Gonsalves, updating the country on the results of the surface exploration phase of the geothermal project stating that a recent report indicated Mount Soufriere is hosting a high temporary geothermal reservoir of commercial use. Gonsalves further mentioned that if everything "goes well and on scheduled", the geothermal plant is scheduled to begin operations in June 2018. St. Vincent and the Grenadines current peak demand for electricity is 20MW with 5MW generated by hydropower. The government is exploring the development of a 5 to 15 MW geothermal power plant to provide base load power to the country. (Source
Care.pdf
für Hospizhelfer Hospiz Landesarbeitsgemeinschaft Niedersachsen e.V. ©Arbeitsgruppe 17.10.2000 Moderation und Ausarbeitung Ulrich Sündermann Hospiz Landesarbeitsgemeinschaft Niedersachsen e.V. DASEIN Hospiz Nienburg / Weser e.V. P M L Krankenhaus Nienburg *Alle Charakterisierungen gelten genauso in der weiblichen Form, und Ausnahmen bestätigen wie immer die Regel. J Stichwort "Palliative Care": Laut Definition (von 1990) der WHO (World Health Organization –Weltgesundheitsorganisation- gegründet 1948) bedeutet "Palliative Care": "Die wirksame, ganzheitliche "care" (Sorge, Obhut, Pflege) von Patienten deren Krankheit nicht mehr kurativ (heilbar) behandelbar ist. Dabei stehen die erfolgreiche Behandlung der Schmerzen und weiterer Symptome (Zeichen von Krankheit) sowie die Hilfe bei psychologischen, sozialen und seelsorgerischen Problemen an erster Stelle. Das Ziel der "Palliative (lateinisch: pallium – der Mantel, übertragen auf Medizin: ummanteln oder umsorgen) Care" ist, die bestmögliche Lebensqualität für Patienten und deren Familie zu erreichen." "Palliative Care" unterstützt Leben und betrachtet Sterben als natürlichen Vorgang. "Palliative Care" will sowohl den Patienten unterstützen um ihm ein möglichst selbstbestimmtes Leben bis zum Tod zu ermöglichen, als auch seinen Angehörigen und Freunden zur Seite zu stehen, damit Sie mit Krankheit und Trauer besser zurechtkommen. Wenn also keine Heilung mehr möglich ist und mit dem baldigen Tod gerechnet wird, gilt es bis zum letzten Atemzug selbst bestimmt zu leben. Dies stellt manchmal in der konkreten Lebenssituation besondere Anforderungen an Hospizhelfer. Anforderungen die selten in Standards geregelt sind und nicht immer auf dem Boden der erlernten klassischen Handlungsweisen erledigt werden können. Besondere Kenntnisse und Maßnahmen sind jetzt erforderlich. Unumstößlich bleibt dabei, dass Hospizhelfer in der Regel keine Krankenpflege leisten. Sicherlich ist es aber von Vorteil, nicht völlig unvorbereitet zu sein. Hier bieten sich Kurse für Pflegende Angehörige an, die von Sozialstationen oder von Krankenkassen durchgeführt werden. In diesen Kursen wird pflegerisches Grundwissen an Laien vermittelt. Die vorliegende Schrift, soll eine Übersicht über Maßnahmen geben, die dem Schwerkranken und Sterbenden Erleichterung, Linderung und Hilfe bieten. Es gilt, den Auftrag des Gesetzgebers bezüglich der GANZHEITLICHKEIT bei der Betreuung [1] sehr ernst zu nehmen. :."pflege heißt, den Patienten in seiner aktuellen konkreten Situation und Befindlichkeit aufzunehmen, ihn anzunehmen, sich ihm liebevoll zuwenden, ihn umsorgen, sich für ihn einsetzen, ihn gegebenenfalls auf seinem Weg zum Tod zu begleiten. Pflege setzt voraus, dass zwischen Pflegenden und Gepflegten, Beziehungen entstehen, in denen anvertrautes Leiden und Leben gemeinsam getragen werden können. Pflege umfasst daher alle Maßnahmen, die notwendig sind und die dazu beitragen, dass der Patient . würdevoll sterben kann." Welche Maßnahmen zur Anwendung kommen, sollte immer mit dem Schwerkranken, sterbenden Menschen und ggf. mit seinen Angehörigen, Freunden und den professionell Pflegenden abgesprochen werden.


The Embassy translates some Lebanese official documents (civil-status extracts, civil-status certificates, driver's license, criminal record) to french.
* The original document to be translated.
* A copy of the Lebanese passport.
* A copy of the residence permit. If available, a copy of the identity card or swiss passport.
* Full names of the father and the mother in French.


text:
LOUISE TAYLOR'S
SCHOOL OF VOICE
DBA Hawaii School of Voice
Schedule Your Lesson Here
About Louise Taylor's School of Voice
Beginning Guitar
Relax and Trust
Louise Taylor's School of Voice
For the singer in you!
Photo of Louise Taylor by Heather Waters
Louise Taylor is a professional musician and vocal coach. She is known for her ability to impart her understanding of the voice, and encourages all of her students to reach beyond their boundaries. She believes that the singing and speaking voice (which are the same instrument) is a powerful means of self-discovery and empowerment. Singing is also a lot of fun, once you get out of your own way. She teaches simple techniques to develop vocal ease and a richer, freer sound.
Louise studied voice with Frank Baker, whose story is below. In honor of Frank's unique legacy, as well as the joy of sharing singing, Louise started the Hawaii School of Voice. She offers private lessons, group workshops, and Your Mindful Voice Retreats to all levels, from beginner to professional.
FRANK BAKER
Frank Baker inspired hundreds of people to sing. He dedicated his life to teaching people how easy and powerful singing can be. Through his deep knowledge and profound understanding of his own instrument, he passed that understanding on to those fortunate enough to study with him. He taught jazz singers, opera singers, rock stars, folk singers, and people who had spent their whole lives believing they could not sing. No one was turned away. He did all this while partially paralyzed from a stroke that would leave him unable to sing for the rest of his life. He continued to teach until his passing.
For more stories and information about Frank Baker, read Louise's Music Blog.
Harley E
I have taken voice lessons from a few different people over the years, and Louise is by far the best teacher I have worked with. She has helped me find more comfort, ease, tone, and range than I knew my voice could have. I have taken lessons in person and over Skype, and don't plan on stopping any time soon.
In addition to technical advice - pitch, tone, control, etc. - Louise helped me burrow into the songs in advance of making a record. It helps that she's superb singer-songwriter in her own right; she's tuned into the spiritual aspects of music-making. In my case, Louise counseled restraint, and consequently audiences seem to be connecting to my songs more than ever. Did I mention that she's a lot of fun?
Wendy B
I initially came to Louise Taylor for help with vocal strain while speaking all day (as a teacher) and singing in my upper range. In the first Skype lesson she identified what was needed for immediate relief, and gave me simple tools to practice on my own--and so much more. In every lesson, she transmits a genuine excitement about the voice, along with her breadth of knowledge. She is present, intuitive, and playful, inspiring the courage to soar beyond my perceived limitations, effortlessly. I'm now singing, speaking, and showing up in the world with more confidence, resonance, and freedom than I realized was possible through vocal study. By Louise's example, I've also learned to hear the soul of other people's singing, making listening more enjoyable and moving than ever.
Tamm J
It is so much more than a singing lesson! Louise is the best voice coach I have ever met. Her whole personality is filled with kind, supportive guidance, and attention that helped me to feel comfortable enough to open up and sing! Highly recommended.
Roxanne S
Louise is a wonderful voice teacher. I came to Louise because my singing was badly off-key, and her lessons have helped so much. Louise helped me to learn to really hear myself, and to hear the notes I'm trying to sing, as well. She actually believes I can hit notes that seem out of my reach to me (!!), and is so patient and encouraging while showing me how to get there. She's taught me that a lot of singing is relaxing into the song, and is great at explaining different techniques to help me relax. She's improvisational, she clearly loves to teach voice lessons, and the lessons are a whole lot of fun!!
If you've always wanted to learn how to sing, or how to improve your singing, I say - definitely Go For It!!!


text:
Fiddle, bouzouki
Teaching in Falls Church, Virginia
seanfiddlemusic@gmail.com
www.seanheely.com
www.facebook.com/seanheelyfiddle
Champion Celtic fiddler and singer Seán Heely is rapidly emerging as one of the most creatively versatile and captivating young artists of his generation. Fiddle legend Liz Carroll calls Seán "One powerhouse of a fiddler." He is a U.S National Scottish Fiddle Champion as well as an award-winning Irish fiddler and singer in the folk traditions of Scotland and Ireland.
Seán holds a degree from University of South Carolina in Classical Violin Performance, and was a 2019 Artist in Residence at Strathmore Music Center in Maryland. An educator in demand, Seán is an Adjunct Instructor at American University. He has also been on the faculty at several summer camps, including Acadia Traditional School of Music and Arts , Upper Potomac Fiddle Retreat, and Fiddle Hell Festival.
He has performed in Scotland, Ireland, and at venues in the U.S such as the Kennedy Center in Washington D.C. Seán has performed with traditional music icons such as Liz Carroll, Bonnie Rideout, Natalie Haas, Cathy Jordan, Maeve Gilchrist, Eamon O'Leary, Zan McLeod, and Paddy Keenan.
Seán performs locally and abroad with the Seán Heely Celtic Trio, Glencoe Lads, and Skylark. He is a musical
ambassador for the British Embassy Scottish Affairs Office and the St. Andrew's Society of Washington. He also frequently travels abroad as a solo artist, has been a speaker at events such as the Scottish North American Leadership Conference, and maintains a private teaching studio in Falls Church, VA.


Cycling North Thailand: Le Tour de Lamphun!
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Immersed in the rich local history and culture you'll pedal along about 40kms of road on a solid full day.
Additional Info: INCLUDED: Experienced bicycle guide, good quality Trek mountain bikes, transportation per songtaew, drinking water, snacks, lunch, insurance, entrance fees, train ticket Chiang Mai - Lamphun, light poncho in the rainy season, Read more... Book Now!
You'll arrive in Lamphun, the ancient capital of the Haripunchai Kingdom. Here you'll get on a high quality American 'brand name' mountain bike (Trek) The ride starts out along the Mae Nam Khuang River. Climbing the old city wall, you'll make your way to Wat Haripunchai, the town's most sacred and respected temple and take in breathtaking sights.
Once you've loaded up on tasty, authentic lunch (included) learn about the Tai Yong people. Most of Lamphun's inhabitants descend from the Tai Yong, an ethnic group from Northern Myanmar.
A visit to the museum featuring fine Tai Yong textiles will open your mind and of course your guide will fill you in with even more on the people's history. Have a keen palette? Next stop is a local fresh food market where you'll be able to discover some native delicacies that will give the tastebuds as much of a work out as the legs!
Cycle through tiny streets and alleys as you leave Lamphun, continuing along roads (some of which are unpaved) to the Ping River. On your journey, you'll pass through scenic rice fields and fruit plantations. Next you will encounter some rural temples that are not frequently visited by tourists.
You'll have the chance to discover markets and shops as you go. Feel free to stop and take in sights that interest you before following the Ping River back to Ban Khanomtom where your day on a tredly (ahem...bicycle!) shall come to an end.
Enjoy refreshments before you're transferred by car to your hotel in Chiang Mai.


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Тhe cubicle, cubicle desk, office cubicle or cubicle workstation is a partially enclosed work space separated from neighboring work spaces by partitions that are usually 5–6 feet (1.5–1.8 m) tall. Its purpose is to isolate office workers from the sights and noises of an open work space so that they may concentrate without distractions. Cubicles are composed of modular elements such as work surfaces, overhead bins, drawers, and shelving, which can be configured depending on the user's needs. Installation is generally performed by professionals, although some cubicles allow configuration changes to be performed by users without specific training.


Cam Newton– Nobody saw last weeks drop off coming. That matchup against the Tennessee Titans should have been a complete joy for owners. Instead fantasy managers were blindsided by a runaway freight train when they checked on Newton's numbers. The Panthers looked like the Panthers of old. They were completely unable to get anything going at all on either side of the ball. Newton disappointed for the first time in 2011 and this game against the Lions could make two in a row. The Lions are a sneaky good defense and provide one of the best pass rushes in the entire league. When Newton decides to run the Lions' defensive ends have enough speed that they could be used to successfully channel Newton up the middle of the field where the linebacking core awaits. This game is a great chance for us to see how Newton not only rebounds from a complete flogging but also how he handles that purposed containment. As well as the Panthers have been this season that offensive line still needs some work. The offensive line is nowhere near the caliber of the talent that makes up the defensive front of the Lions. Newton will have much less time in the pocket to wait for the deep routes to develop. That means that he won't be able to connect with Steve Smith in the same manner that they have grown accustomed to. Newton will need to be accurate on his short passes and move the chains with short chunks of yardage. Don't expect either DeAngelo Williams or Jonathan Stewart to be huge factors in the running gaming, per usual. Newton will have a huge workload and will need to be extremely efficient to avoid turnovers. This game gives us the opportunity to see not only how Newton handles intense pressure but also how accurate he really is. Newton's accuracy has been highly scrutinized since his college days. It's one thing to throw a complete bomb down the field to a receiver as fast as Steve Smith in a "go and get it" type of mentality compared to needing to be spot on when given a small window to throw into. I expect Newton to provide owners with another solid, number one quarterback outing. But I also expect him to play like a rookie quarterback and make a few mental mistakes that will sway the game. The yardage will be there but so will the turnovers and the sacks.
Michael Bush– Oakland is currently in a situation that fantasy owners lose sleep over. What do you do with a wealth of talent at running back? Does Bush go back to the bench once Darren McFadden is fully healthy? Does Bush's workload increase or does he go back to being ridiculously underused? Several teams over the past season have found themselves in this exact situation and the results are quite mixed. The Texans have seemingly found a way to utilize both of their backs in a successful manner. The Jets have found a way to platoon Shonn Greene and LaDainian Tomlinson with success. However in a case like the Dolphins, Reggie Bush has all been taken starting duties away from Daniel Thomas due to injury. Demarco Murray in Dallas has become the main threat in Felix Jones' absence. It's completely up to the team in question as to how exactly the situation will play out. Some teams believe that players don't lose their jobs due to injury while other teams like the Broncos believe in riding the hot hand. There is no doubt that Darren McFadden has his job awaiting him in Oakland upon his return. The question is how does Bush effect his value from here on out? We could be in a Mike Tolbert and Ryan Mathews situation. The overall yardage will be easy to judge but the scoring opportunities could become quite murky. As of this moment it doesn't appear likely that McFadden will be able to go on Sunday. Bush will have yet another chance to rank up the stats and prove that he's a dynamic player that needs to get his fair share. If Bush can impress in the way that he did last week against the Chargers there will be no debate about getting an increased workload. As Bush's value increases Darren McFadden's value inevitably decreases. Both Michael Bush and Darren McFadden owners should watch intently on Sunday because this game has huge future value implications.
Felix Jones– Much like the aforementioned situation in Oakland, we have another one currently unveiling in Dallas. Felix Jones was the highly touted preseason favorite to be the dynamic playmaker out of the Dallas backfield. But much like the years before, Jones hasn't managed to stay on the field. A dislocated shoulder and a high ankle sprain have limited what could have been a monster season. The ankle injury was especially detrimental because it opened the gates for DeMarco Murray. This week against the Redskins will give us our first look as to how Jason Garrett will handle the backfield situation. After what we've seen from the rookie there doesn't seem to be a chance for Jones' value to go back to what it was again. By again I'm not just implying the 2011 season. I mean again as in for the rest of Jones' career with the Cowboys. Felix will need either a severe injury to Murray or a new zip code to regain his value. Jones will likely slip back into his complimentary role and fall into fantasy purgatory. Fantasy purgatory is that place where a player shows great potential each week but doesn't receive the workload to be trusted in your lineup. I'd expect Felix to receive carries only when Murray needs a break. Felix's main value will come through the passing game and those touches don't provide enough work to really count on him. If Murray were to continue to excel, even with Felix Jones in tow, DeMarco's value would rise even further in my eyes. We'd know that Garrett wouldn't patronize Jones with carries to appease him therefore regulating Murray's value to a medium. Much like the Raiders' game, both Jones and Murray owners should pay close attention to how the backs are used on Sunday. Sadly for Jones owners there isn't going to be much to hang your hats on after Murray continues to roll even with Jones active.
Ryan Fitzpatrick– The second quarter of season has been the polar opposite of the first quarter for the Bills. They have seemingly stumbled and fallen out of the AFC east elite category. Luckily for the Bills though there is still someone in the AFC east that has stumbled even harder. The Dolphins should be the perfect team for the Bills to get back on track with offensively. Ryan Fitzpatrick should be able to get back to his early season form against a Dolphins' defense that struggled to stop anyone. The cornerbacks for Miami have been in and out of the lineup with injuries, creating inconsistency in a position that wasn't that good to begin with (no matter how much they want to compare themselves with the Jets). As long as Steve Johnson is able to go in week 11 expectations for Fitzpatrick should remain high. As I said the Dolphins defense presents a great chance for the Bills' offense to find itself again. I didn't say that the Bills defense was going to be able to do anything special. The Dolphins have found their offensive grove and will exploit the Bills' inability to stop the run. That factor will also bode well for the Bills offense getting back on track. Look for Fitzpatrick to have the best fantasy day that he's had in several games. With all the terrible quarterback matchups and bye weeks don't be surprised to see Fitzpatrick finish in the top seven or so in quarterback scoring. Expectations will need to be lowered if Steve Johnson isn't able to go but the other guys like David Nelson and Scott Chandler would be able to pick up some of the slack.


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Derek began his career as a lawyer in 2003 with a small group of experienced lawyers. It was there Derek sharpened his skills as a litigator and counselor. Born in Chicago, Illinois, and well traveled, Derek has called New Orleans home for two decades. He has represented clients before many state courts, as well as those in Louisiana's federal courts and beyond. Derek became a member of the Louisiana Bar in 2003. He is also admitted to practice before the United States District Court in the Eastern, Middle and Western Districts of Louisiana and the U.S. Fifth and Seventh Circuit Courts of Appeal. Derek earned a Bachelor's degree from the University of Florida in 1996. He continued his academic pursuits and earned a Law degree from the University of Virginia in 2003, where he served as a Senior Editorial Board Member for the Journal of Social Policy and the Law.
Derek is active in a number of professional organizations including the Louisiana State and American Bar Associations, and the New Orleans Bar Association. He is also a Young Fellow of the New Orleans Museum of Art and a member of the New Orleans Citizens Diplomacy Counsel. Derek treats every client with respect and integrity.


text:
Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials
Xiao Ming Xie, Nicholas E. Geacintov, Suse Broyde
When covalently linked to DNA, enantiomeric pairs of mirror image aromatic diol epoxides with differing tumorigenic potencies adopt opposite orientations along the DNA helix. This phenomenon has been observed by high- resolution NMR solution studies in a number of systems. Preliminary modeling efforts [Geacintov et al. (1997) Chem. Res. Toxicol. 10, 111-146) had suggested that the origin of the opposite orientation effect may be manifested even at the level of the carcinogen-modified nucleoside due to primary steric hindrance effects between the aromatic moiety and the attached base and sugar. Such a small system can be computationally investigated extensively, since a very thorough survey of the potential energy surface is feasible. Consequently; in an effort to understand the underlying origins of the opposite orientations in (+)-trans and (-)-trans-anti adduct pairs, we have undertaken an extensive investigation of the paradigm 10S (+) and 10R (- )-trans-anti-[BP]-N2-dG mononucleoside adduct pair, derived from the binding of the (+)-7R,8S,9S,10R and (-)-7S,8R,9R,10S enantiomers of 7,8-dihydro-9,- 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BP) to the exocyclic amino group of 2'-deoxyguanosine. In the present work we created 373248 different conformers for each adduct, which uniformly sampled the possible rotamers about the three flexible torsion angles governing the orientation of the base (χ) and its covalently linked BP residue (α', β') at 5°intervals, and Computed each of their energies with AMBER 4.0. The extensive results permitted us to map the potential energy surface of the molecule. Only four low-energy structural domains are found for the (+)-trans adduct and four for the (-)-trans adduct; the (+)/(-) pairs of each structural domain are mirror images, with the mirror image symmetry broken by the sugar and its attached C4'-C5' group. The most favored of these four is observed experimentally in the duplexes containing the same (+) and (-)-trans-anti-[BP]-N2-dG adducts (Cosman et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 1914-1918; de los Santos et al. (1992) Biochemistry 31, 5245-5252). The origin of the opposite orientations resides in steric hindrance effects resulting from the mirror image relationship of the BP benzylic rings in the adduct pair, such that rotation of one stereoisomer into the conformational domain preferred by the other causes crowding between the base and the BP benzylic ring. Limited conformational flexibility in the torsion angle β', the one closest to the bulky BP moiety at the linkage site to guanine, plays a key role in governing the orientations in each adduct. The opposite orientation phenomenon is likely to manifest itself when the adducts are processed by cellular enzymes involved in replication, repair, and transcription and thus play a role in the differing biological outcomes stemming from the (+) and (-)-trans-anti adducts.
https://doi.org/10.1021/bi9825605
10.1021/bi9825605
Fingerprint Dive into the research topics of 'Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials'. Together they form a unique fingerprint.
Epoxy Compounds Chemical Compounds
DNA Adducts Chemical Compounds
9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene Medicine & Life Sciences
Mirrors Chemical Compounds
Sugars Medicine & Life Sciences
Potential energy surfaces Chemical Compounds
Deoxyguanosine Medicine & Life Sciences
Xie, X. M., Geacintov, N. E., & Broyde, S. (1999). Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials. Biochemistry, 38(10), 2956-2968. https://doi.org/10.1021/bi9825605
Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials. / Xie, Xiao Ming; Geacintov, Nicholas E.; Broyde, Suse.
In: Biochemistry, Vol. 38, No. 10, 09.03.1999, p. 2956-2968.
Xie, XM, Geacintov, NE & Broyde, S 1999, 'Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials', Biochemistry, vol. 38, no. 10, pp. 2956-2968. https://doi.org/10.1021/bi9825605
Xie XM, Geacintov NE, Broyde S. Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials. Biochemistry. 1999 Mar 9;38(10):2956-2968. https://doi.org/10.1021/bi9825605
Xie, Xiao Ming ; Geacintov, Nicholas E. ; Broyde, Suse. / Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials. In: Biochemistry. 1999 ; Vol. 38, No. 10. pp. 2956-2968.
@article{14ed3c8e1d414af38ece407185571352,
title = "Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials",
abstract = "When covalently linked to DNA, enantiomeric pairs of mirror image aromatic diol epoxides with differing tumorigenic potencies adopt opposite orientations along the DNA helix. This phenomenon has been observed by high- resolution NMR solution studies in a number of systems. Preliminary modeling efforts [Geacintov et al. (1997) Chem. Res. Toxicol. 10, 111-146) had suggested that the origin of the opposite orientation effect may be manifested even at the level of the carcinogen-modified nucleoside due to primary steric hindrance effects between the aromatic moiety and the attached base and sugar. Such a small system can be computationally investigated extensively, since a very thorough survey of the potential energy surface is feasible. Consequently; in an effort to understand the underlying origins of the opposite orientations in (+)-trans and (-)-trans-anti adduct pairs, we have undertaken an extensive investigation of the paradigm 10S (+) and 10R (- )-trans-anti-[BP]-N2-dG mononucleoside adduct pair, derived from the binding of the (+)-7R,8S,9S,10R and (-)-7S,8R,9R,10S enantiomers of 7,8-dihydro-9,- 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BP) to the exocyclic amino group of 2'-deoxyguanosine. In the present work we created 373248 different conformers for each adduct, which uniformly sampled the possible rotamers about the three flexible torsion angles governing the orientation of the base (χ) and its covalently linked BP residue (α', β') at 5°intervals, and Computed each of their energies with AMBER 4.0. The extensive results permitted us to map the potential energy surface of the molecule. Only four low-energy structural domains are found for the (+)-trans adduct and four for the (-)-trans adduct; the (+)/(-) pairs of each structural domain are mirror images, with the mirror image symmetry broken by the sugar and its attached C4'-C5' group. The most favored of these four is observed experimentally in the duplexes containing the same (+) and (-)-trans-anti-[BP]-N2-dG adducts (Cosman et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 1914-1918; de los Santos et al. (1992) Biochemistry 31, 5245-5252). The origin of the opposite orientations resides in steric hindrance effects resulting from the mirror image relationship of the BP benzylic rings in the adduct pair, such that rotation of one stereoisomer into the conformational domain preferred by the other causes crowding between the base and the BP benzylic ring. Limited conformational flexibility in the torsion angle β', the one closest to the bulky BP moiety at the linkage site to guanine, plays a key role in governing the orientations in each adduct. The opposite orientation phenomenon is likely to manifest itself when the adducts are processed by cellular enzymes involved in replication, repair, and transcription and thus play a role in the differing biological outcomes stemming from the (+) and (-)-trans-anti adducts.",
author = "Xie, {Xiao Ming} and Geacintov, {Nicholas E.} and Suse Broyde",
doi = "10.1021/bi9825605",
journal = "Biochemistry",
T1 - Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials
AU - Xie, Xiao Ming
AU - Geacintov, Nicholas E.
AU - Broyde, Suse
N2 - When covalently linked to DNA, enantiomeric pairs of mirror image aromatic diol epoxides with differing tumorigenic potencies adopt opposite orientations along the DNA helix. This phenomenon has been observed by high- resolution NMR solution studies in a number of systems. Preliminary modeling efforts [Geacintov et al. (1997) Chem. Res. Toxicol. 10, 111-146) had suggested that the origin of the opposite orientation effect may be manifested even at the level of the carcinogen-modified nucleoside due to primary steric hindrance effects between the aromatic moiety and the attached base and sugar. Such a small system can be computationally investigated extensively, since a very thorough survey of the potential energy surface is feasible. Consequently; in an effort to understand the underlying origins of the opposite orientations in (+)-trans and (-)-trans-anti adduct pairs, we have undertaken an extensive investigation of the paradigm 10S (+) and 10R (- )-trans-anti-[BP]-N2-dG mononucleoside adduct pair, derived from the binding of the (+)-7R,8S,9S,10R and (-)-7S,8R,9R,10S enantiomers of 7,8-dihydro-9,- 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BP) to the exocyclic amino group of 2'-deoxyguanosine. In the present work we created 373248 different conformers for each adduct, which uniformly sampled the possible rotamers about the three flexible torsion angles governing the orientation of the base (χ) and its covalently linked BP residue (α', β') at 5°intervals, and Computed each of their energies with AMBER 4.0. The extensive results permitted us to map the potential energy surface of the molecule. Only four low-energy structural domains are found for the (+)-trans adduct and four for the (-)-trans adduct; the (+)/(-) pairs of each structural domain are mirror images, with the mirror image symmetry broken by the sugar and its attached C4'-C5' group. The most favored of these four is observed experimentally in the duplexes containing the same (+) and (-)-trans-anti-[BP]-N2-dG adducts (Cosman et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 1914-1918; de los Santos et al. (1992) Biochemistry 31, 5245-5252). The origin of the opposite orientations resides in steric hindrance effects resulting from the mirror image relationship of the BP benzylic rings in the adduct pair, such that rotation of one stereoisomer into the conformational domain preferred by the other causes crowding between the base and the BP benzylic ring. Limited conformational flexibility in the torsion angle β', the one closest to the bulky BP moiety at the linkage site to guanine, plays a key role in governing the orientations in each adduct. The opposite orientation phenomenon is likely to manifest itself when the adducts are processed by cellular enzymes involved in replication, repair, and transcription and thus play a role in the differing biological outcomes stemming from the (+) and (-)-trans-anti adducts.
AB - When covalently linked to DNA, enantiomeric pairs of mirror image aromatic diol epoxides with differing tumorigenic potencies adopt opposite orientations along the DNA helix. This phenomenon has been observed by high- resolution NMR solution studies in a number of systems. Preliminary modeling efforts [Geacintov et al. (1997) Chem. Res. Toxicol. 10, 111-146) had suggested that the origin of the opposite orientation effect may be manifested even at the level of the carcinogen-modified nucleoside due to primary steric hindrance effects between the aromatic moiety and the attached base and sugar. Such a small system can be computationally investigated extensively, since a very thorough survey of the potential energy surface is feasible. Consequently; in an effort to understand the underlying origins of the opposite orientations in (+)-trans and (-)-trans-anti adduct pairs, we have undertaken an extensive investigation of the paradigm 10S (+) and 10R (- )-trans-anti-[BP]-N2-dG mononucleoside adduct pair, derived from the binding of the (+)-7R,8S,9S,10R and (-)-7S,8R,9R,10S enantiomers of 7,8-dihydro-9,- 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BP) to the exocyclic amino group of 2'-deoxyguanosine. In the present work we created 373248 different conformers for each adduct, which uniformly sampled the possible rotamers about the three flexible torsion angles governing the orientation of the base (χ) and its covalently linked BP residue (α', β') at 5°intervals, and Computed each of their energies with AMBER 4.0. The extensive results permitted us to map the potential energy surface of the molecule. Only four low-energy structural domains are found for the (+)-trans adduct and four for the (-)-trans adduct; the (+)/(-) pairs of each structural domain are mirror images, with the mirror image symmetry broken by the sugar and its attached C4'-C5' group. The most favored of these four is observed experimentally in the duplexes containing the same (+) and (-)-trans-anti-[BP]-N2-dG adducts (Cosman et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 1914-1918; de los Santos et al. (1992) Biochemistry 31, 5245-5252). The origin of the opposite orientations resides in steric hindrance effects resulting from the mirror image relationship of the BP benzylic rings in the adduct pair, such that rotation of one stereoisomer into the conformational domain preferred by the other causes crowding between the base and the BP benzylic ring. Limited conformational flexibility in the torsion angle β', the one closest to the bulky BP moiety at the linkage site to guanine, plays a key role in governing the orientations in each adduct. The opposite orientation phenomenon is likely to manifest itself when the adducts are processed by cellular enzymes involved in replication, repair, and transcription and thus play a role in the differing biological outcomes stemming from the (+) and (-)-trans-anti adducts.
U2 - 10.1021/bi9825605
DO - 10.1021/bi9825605
JO - Biochemistry
JF - Biochemistry


text:
60% of Americans Unaware of Electric Cars
December 27, 2016 • by Staff
Photo courtesy of Volvo.
About 60% of Americans remain unaware of battery-electric vehicles and 80% have never driven or ridden in one, according to a new survey from Altman Vilandrie & Co.
More than 2,500 consumers were questioned in the survey, which also found that a clear majority of consumers who have been inside an EV enjoyed it and many more consumers would purchase an EV if lower-priced models were available.
The arrival of lower-priced EVs in 2017 could increase adoption with the arrival of the Chevrolet Bolt and Tesla Model 3, which are expected to cost around $35,000. Chevrolet has begun shipping its vehicle, while the Tesla model should arrive in late 2017.
The release of less expensive models by other automakers would boost EV adoption by nearly 24 times the current market, Altman Vilandrie & Co. reported.
The survey shows that a perceived lack of charging stations (85%), high costs (83%) and uncertainty over duration of charge (74%) were the top reasons for not wanting to purchase an EV.
About 3% of survey respondents said they currently own an EV, while 10% said they plan to buy an EV as their next car. About 60% of consumers who have experienced an EV say they enjoyed the experience, while only 8% reported not enjoying it.
Related: Fleets Can Reduce Costs by 25% with EVs
Read more about Battery-Electric Vehicles Survey Consumer Sentiment
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Ford, VW Partner on Autonomous Driving, High-Volume EV for Europe
Volkswagen will invest in Ford's Argo AI autonomous vehicle platform. Ford will use VW's electric vehicle architecture to design and build at least one high-volume fully electric vehicle in Europe for European customers starting in 2023.
CARB Approves Lightning Systems' Electric Ford Transit
The California Air Resources Board (CARB) approved the second generation model of Lightning Systems' battery-electric Ford Transit 350HD.
First Battery-Electric Mini Arrives in 2020
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Walmart To Install EV Charging Stations Across Arkansas
As part of a coast-to-coast charging initiative, Walmart plans to install EV charging stations across the state, with plans to expand to an additionally 46 states.
Range Rover's 2019 P400e Plug-in Hybrid
Land Rover's 2019 Range Rover HSE P400e arrives as a plug-in hybrid variant of Range Rover's flagship SUV.
Clean Cities Funding Preserved
U.S. Congressman Paul Gosar did not offer an amendment to the FY-2020 Department of Energy budget, one that would have eliminated funding for the Clean Cities program.
ChargePoint, Electrify America Sign Roaming Agreement
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