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Sofitel New York
45 W 44th Street, New York City, USA
Maybe we just have a soft spot for all things French. Or maybe it's the case that for a big-business hotel chain, Sofitel seems to have it pretty well figured out — the consistent quality of a corporate hotel, but with the personality too many others lack, and an aesthetic sense that we may as well just go ahead and describe as Parisian, as long as we're not shying away from cultural stereotypes.
The Sofitel New York's curvaceous glass tower turns heads along 44th street, between Fifth and Sixth avenues; this is that part of Midtown that feels close by to everything in the world. There are just shy of four hundred rooms, most of which have some sort of dramatic view or another; the Chrysler Building, if you're lucky, or just a bird's-eye-view of 44th.
Inside they're handsome, but far from over-designed, and comfortable verging nearly on luxurious — separate showers and tubs, standard here, are not exactly common in New York's tight spaces. Topping off the Paris-in-NYC experience is Gaby, a French restaurant of course, and Gaby Bar, both named for a Parisian model made good in Twenties New York, both decorated in an Art Deco style that inspires that particular prewar nostalgia that's Midtown's specialty.
Wi-fi (charges apply)
ATM/bank office
Offsite gym facilities
Bikes available
Gabriel Kreuther
The Lambs Club
$$$ · American
Sushi Ginza Onodera
Szechuan Gourmet
$$ · Chinese
Le Pavillon
Le Rock
Ai Fiori
New York City Hotels
© Sofitel New York


By James Lara on Mar 27, 2014 - 21 Comments.
Along with the PlayStation 3 back in 2006 launched a small first-person-shooter called "Resistance: Fall of Man". Many years later, developer Insomniac Games would follow up with two sequels. Although the series has since lost its meaning, we take a look back at what made it so good to begin with.
March 28 marks the day online support for the trilogy is cut off, so we figured now would be a good time to recall our favorite Resistance memories as servers begin to shut down.
The premise of the game's story was really nothing new. The world is at war with itself as a plague alien virus (Chimera) spreads through most of Europe, infecting and killing millions. Those who survived suffered a fate worse than death, as they were converted into monsters – a part of the Chimera race. All seemed lost, and even though the game ended with the hero doing what he came to accomplish, most, if not all of Europe had been lost by then.
The game's story wasn't blockbuster material, but it was the dark atmosphere that truly gave Fall of Man a sense of panic and despair. This theme was felt throughout the multiplayer as well. Map design reflected that of a dying world, overrun and terraformed to suit the Chimera's needs. The multiplayer felt like a natural continuation of the single-player in the sense that very same fight for survival continued. It also helped that the multiplayer itself was packed with content that hasn't been seen in a multiplayer title before at the time, at least on consoles.
Before the PS3 had an in-game XMB, limiting basic functions like checking messages or friends lists, etc., developers had to go out of their way to provide gamers with the essentials. Resistance: Fall of Man was the game that had it all; a lobby system, fully functioning voice and text chat, a clan system that had roles in it. It basically put most games to shame when it came to clan organization. An in-game friends-list also came with in-game messaging, all achieved with dedicated servers that also ran the game. It provided its own ecosystem for gamers and almost everything anyone could ever wish for in terms of player options was most likely there. It was clear that Insomniac Games had something going here.
Fall of Man also boasted one of the highest player counts seen in an FPS yet with 40-player online combat, or 20 vs. 20. Though map sizes were quite large, players were still easily found. Though it only featured about twelve weapons, they were some of the most inventive weapons out there. You'd find a mix of older WW2 weapons, such as the Assault Carbine or the Rossmore Shotgun, mixed with weapons like the Bullseye, an Alien weapon that could tag players, or the Dragon, a powerful flamethrower. They all added to a unique experience. The grenade selections were great as well, like my personal favorite: the Air-fuel grenades. These were fun to watch and get kills with or even be killed by. They were quite comparable to Halo's plasma grenades, only more deadly.
Fall of Man's multiplayer was a complete package with it's unique game-modes, dedicated servers, player options, ect. The game showcased many promises for future installments. It was a title I definitely feel was worth keeping after all these years, only to throw it back in for one final hoorah.
Resistance 2 had high expectations. From the early showings, it seemed clear that the next step was to make the game bigger with even bigger enemies. The bosses in Resistance 2 were huge – made up of multiple human bodies. Though an impressive feat, the story paid a huge price. With the setting now in the United States, the Chimera had started their first invasion on the US soil, and like Americans have always been portrayed, they weren't going to give up easily. The let down here was that the core ideas of the first game – humans on the brink of death – were basically thrown-out. It made sense that the US had gathered intel on the Chimera, creating super soldiers and futuristic weapons of their own. But it made for an odd choice in art style that lacked the original atmosphere of the original. It vanished not only in the single-player, but in the multiplayer as well.
To continue with the idea that bigger is better, Resistance 2 boasted an increased player count – from 40 to 60 players. While it might have sounded like a good idea, map design and balancing ultimately lead to an unbearable experience. With the PS3's new in-game XMB the need for friends list and a messaging system was no longer there, which was a mistake, in my opinion. The XMB was, and still is, a slow pile of filth when being used in-game. Insomniac Games also made another mistake by removing one of the game's most stand out features: the Clan system. The surprising move led to a much less enjoyable experience. The game wasn't "bad", but it definitely didn't live up to expectations, which eventually ended up hurting the third installment in sales.
The only thing that this game really had going for it was the co-op. It featured eight – and I'll say it again – EIGHT player online co-op, the first of its kind on consoles. It was fun too – a hoard-ish type of mode, except with objectives, much like Left 4 Dead. It even featured three special classes, each with their own abilities and leveling system. I think many would agree that was the best thing going for Resistance 2.
I had my doubts after Resistance 2, but the third installment had the potential to redeem the series, and it did, to a degree. Starting with the story, it goes back to the root idea that the Chimera are the ultimate threat and will most likely win by the time this is all over. It takes place once again in America, only this time, the population has shrunk to almost nothing. There is no hope left as the Chimera have advanced so far, humankind can't keep up. Resistance 3 returned back to the series' grittiness that made the original so great to begin with.
That them once again transferred over to the multiplayer rather seamlessly. Though instead of going with an even bigger player count, Insomniac decided to shrink it, drastically. The count had shrunk from 60 to just 16 players! Map sizes were also significantly smaller to accommodate the smaller player count. While the multiplayer didn't scream "come play me! I'm your new addiction," it was once again a very enjoyable experience. It was clear, however, that the game was heavily influenced by Call of Duty's fast-paced, closed-quarters formula with killstreak rewards. With that, Resistance 3's multiplayer had felt like it lost it's "mojo," so to speak, and because of that, the multiplayer died out quickly.
The question here was, what made the franchise so good? To be blunt, perhaps there wasn't much of a reason. I'm not even entirely certain it should be considered "good". I enjoyed the first a whole lot, but was severely disappointed with its sequel. Resistance provided a great story at a time when FPS games lacked in that department, but its multiplayer just felt like it was trying to be something else. I guess there was always a shimmer of hope that the franchise would grow into something better, keeping a hold of its original roots without getting too creative. But, at the end of its journey, Resistance 3 was a game with a mistaken identity.
Here's to hoping that the next iteration will be handled perhaps by an internal team at Sony, seeing that Insomniac probably doesn't want much to do with the franchise.
What are your memories of the Resistance series?


The signing of a non-compete agreement, to some employees, can feel like just one more document that must be dealt with before employment can officially begin. But these documents are not just insignificant human resources paperwork – non-compete agreements are serious and binding. A non-compete clause makes clear that an employee agrees they will not start a similar business that competes against their current employer, nor will they take a similar job with a competitor or transfer any trade secrets or proprietary information while they are in their current position with you or for a specific period of time after leaving your company.
Increasingly, however, more and more employees are entering into non-compete agreements only to secretly build their own competing enterprise against your company, or to sell and market your company's investment in them to a competitor. The economic damage that results from blatantly ignoring the rules of a non-compete agreement can be tremendous and reverberate through all levels of your organization, no matter what position the offending employee holds or once held. Conducting a non-compete agreement investigation through an experienced private investigator is critical to protect your company.
While it is often common to hear people say that non-compete agreements are unenforceable and hardly worth the paper they're written on, nothing could be further from the truth. Unless the non-compete agreements are unrealistic in time frame or geographic location, or overreaching in the kind of secrecy they require, they are indeed valid and can be used to achieve non-competition enforcement. The non-compete agreement can even be used to secure costs and attorney fees from the former employee who is committing the violation, but evidence of this transgression is absolutely needed first.
When you discover that an employee or former employee is violating the non-compete agreement they signed, which means they're essentially violating your company and the trust you had in them, your first instinct may be to call law enforcement or your attorney. Unfortunately, stopping the offender in their tracks is the opposite of what you want to do. Any cease-and-desist or threatening letters sent to the non-compete agreement violator will put them on notice that you've been made aware of their underhanded behavior. In an effort to avoid punishment or legal action, they'll stop or go underground with their efforts. This kind of behavior makes it incredibly difficult to gather evidence and build a legitimate case against them.
Before committing to a course of action, no matter how satisfying it may be to catch the offender in the act, contact a private investigator. Not only do we at ASG have a proven track record of developing evidence for non-compete agreement violations, we use appropriate methods to conduct our investigation to prevent the risk of liability to you regarding invasion of privacy.
Being too close to an issues that is threatening the well-being and future of your company is a recipe for disaster. You are undoubtedly wrapped up in keeping your business profitable and legitimate, which means it can be tempting and very easy to act rashly in an effort to safeguard your business. Take the information you have gathered and share it with us. ASG is not only able to build an actionable case for you to see justice and non-competition enforcement, we are able to identify others who are involved in this behavior along with third-party witnesses.
Through a combination of surveillance, background information collection, interviews, computer and cell phone forensics, open source data mining, and more, ASG produces a complete non-compete agreement enforcement investigation to support your recovery options. These same techniques can be invaluable in investigating violations of restrictive covenants and trade secret agreements.


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In 24 hrs, four children among five die as Firozabad reels under viral fever
In view of the rising cases, the Firozabad district administration has issued a 24-hour helpline number for those in need. People can call on 05612285062 or WhatsApp on 8859333909 for queries or lodge complaints.
Deepak Lavania
August 28, 2021, 11:21 IST
Agra: Four children aged between six and 16 years were among five people who succumbed to suspected viral fever while undergoing treatment in Firozabad district in the last 24 hours. A 25-year-old woman suffering high fever also died on Wednesday evening. During the same period, 12 children suffering from suspected dengue were admitted at the Firozabad Medical College.
Firozabad is one of the worst-affected districts in Agra division reeling under viral fever. In the last one week, at least 40 people suffering from viral fever with dengue-like symptoms -- cough, cold, dehydration and body ache -- have died in Agra, Firozabad, Mathura and Mainpuri districts. Health department records show that Firozabad alone accounted for some 22 deaths
Most of the patients are residents of rural areas and are dependent on quacks for treatment. Now, the health department has sent out medical teams in the villages to provide medicines to the patients.
Due to the rush of patients, government hospitals are running out of beds. As Shailendra Kumar of Peepal Nagar in Firozabad put it, "My six-year-old son was suffering from viral fever and we had to admit him to a private hospital as the district hospital had no beds. But he died on Wednesday due to low platelet count and high fever."
Doctor Neeta Kulshrestha, chief medical officer of Firozabad district, said, "The cause of the death of patients suffering from fever is being investigated. "
Confirming that all beds are full, Dr Hansraj Singh, chief medical superintendent of Firozabad Medical College, said, "We have increased the number of beds in the children's ward from 20 to 75. Additional beds are also being added in the general ward. Thirty beds reserved for the Covid-19 patients are being used for patients with viral fever."
Superintendent in-charge of Agra district hospital, Dr AK Agarwal said, "We are getting at least 200 patients of viral fever at the out-patient department every day. The number of these patients has significantly increased over the past three weeks. This time the intensity of viral fever is higher than previous years. Children are most vulnerable to viral infections."
Chief medical officer of Agra district, Dr Arun Kumar Srivastava attributed changing weather conditions as the key factor behind the spread of viral fever. He advised people to maintain sanitation and hygiene, avoid direct contact with a sick person and crowded places and to drink plenty of water to remain healthy.
four children among five die as Firozabad reels under viral fever
In 24 hrs
firozabad medical college
district hospital
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redpajama_set_name: RedPajamaCommonCrawl


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How Can I Watch Cnn on Apple TV Without Cable?
If you want to watch CNN on your Apple TV, there are several ways. One is through Sling TV, which offers access to the channel's live stream. The Sling app is available on Android, Xbox, Roku, Apple TV, and more. Another way is to use Hulu Live TV.
Hulu offers a "With Live TV" subscription package, which includes access to its entire on-demand video library. It also has cable networks like A&E, MSNBC, and more. This is a great option for those looking to cut the cord.
CNN is a 24-hour news network that covers events around the world. There is a variety of programming, including debates and election results.
You can access the CNN Go app on a wide range of devices, including Fire TV, Apple TV, Roku, and more. To get started, you'll need to create an account and provide credentials for your cable or satellite TV provider. After you have your username and password, you can launch the app.
You can also watch CNN online through a number of live TV streaming services. You can sign up for a free trial and choose the best one for you.
How Can I Watch CNN For Free on Apple TV?
How Can I Watch CNN Live Without Cable?
Can You Watch CNN with Apple TV?
How Much is CNN Live on Apple TV?
How Do I Add CNN to Apple TV?
How Can I Watch News on Apple TV Without Cable?
Can I Watch CNN Live on YouTube?
CNN is one of the most popular news channels in the world. It's well known for its coverage of world events, politics, sports, and entertainment. If you're a fan, there are a number of ways to watch CNN for free.
You can watch CNN online on your PC, tablet, or smartphone. CNN is a great source for breaking news and original programming. There are many streaming services, including Hulu and Sling TV, that can provide you with all of your CNN needs.
If you're looking to cut the cord, Hulu offers a "With Live TV" package that includes access to Hulu's entire on-demand video library. For a limited time, you can get your first week of service for free. This is a great way to test out a streaming service without committing to a long-term commitment.
READ ALSO: Why is My Apple TV Blinking?
Another option is to watch CNN for free on YouTube TV. The video service offers ad-free, interactive news experiences. In addition to CNN, it's also a great source for US government news.
If you're looking to watch CNN live without cable, there are a couple of options. Sling TV and Hulu with Live TV are both good choices. Both services offer a free trial period so you can try out the service before signing up for a subscription.
Streaming services such as DIRECTV Stream, Hulu With Live TV, and Sling TV work with a variety of devices, including PCs, tablets, and TVs. They also provide a range of channels, including Disney XD and E! Plus, you can choose to upgrade with smaller add-on channel bundles.
Sling TV is the cheapest way to get CNN. It offers affordable monthly subscriptions and no contracts. You can get a free 7-day trial if you're interested in trying out the service. The service works with Roku, Android phones, Smart TVs, Chromecast, and more.
To watch CNN online, you need a stable Internet connection. In addition, you will need to sign up for a CNN account. This is the same information you would have provided for a cable or satellite TV provider.
If you have an Apple TV and are a cable or satellite TV subscriber, you may be wondering if you can watch CNN on your Apple TV without cable. This can be done using the CNN application. However, you will need to have a subscription to a streaming service.
Streaming services provide 24-hour news coverage. Some of these services are free and others are very affordable. You will be able to choose from a variety of channels, including CNN, HBO, MSNBC, FOX, and more. These are all available on a number of devices, such as your PC, tablet, and smartphone.
You can access the CNN app through your Android or iOS device. This app will allow you to watch live audio, read articles, and sign up for live Q&A sessions. Using the app, you will also have the option of casting to your Chromecast.
You can also use a VPN to access the CNN website from abroad. To do so, you will need to choose a US-based VPN server. The best VPNs offer excellent unblocking power and a wide variety of server locations.
READ ALSO: Is the New York Times Available on Apple News?
CNN is one of the most widely watched news channels in the world. It covers breaking news and current affairs from all over the globe.
CNN is available on TV, tablet, smartphone, and other streaming devices. CNN is a 24-hour news network. In addition to covering the news, CNN is known for its original programming and financial advice.
You can also watch CNN live on Apple TV. However, you need to have cable service or a subscription to a stream service. There are several alternatives, including Sling TV, Hulu with Live TV, and YouTube TV.
Sling TV is the cheapest way to watch CNN without cable. The service costs $35 a month, and you get access to a mix of live television channels. Some packages also include a Cloud DVR for 50 hours of recorded programming. As well, there are no hidden fees.
Hulu with Live TV offers a free 7-day trial. During this time, you'll be able to watch a variety of shows, including CNN's flagship shows, plus documentaries, movies, and more. If you like what you see, you can upgrade to a larger package for a discounted rate.
The CNN app is available on a number of platforms. It can be downloaded from both the App Store and the Google Play store. You can also access it from the browsers on your mobile devices.
CNN has been around for more than four decades and has a wide variety of programming, including political, sports and entertainment coverage. In addition to its original news and documentary shows, it also covers events in the world, business, and health. A subscription to the service should cost just a few bucks a month.
CNN is also available on various streaming services, including Sling TV and DIRECTV STREAM. These services have widespread device support and offer free trials. However, you need to make sure that you have an iOS device or a Wi-Fi router.
You can also live stream CNN through platforms such as Hulu with Live TV and fuboTV. If you want to watch CNN on Apple TV, you can use the screen mirroring feature. To do this, you need to log into your cable provider account and then enter your credentials.
READ ALSO: How To See Calculator History On iPhone?
CNN is the leading news channel in the United States. It provides 24-hour news coverage and personality-driven content. The channel has also produced award-winning documentaries.
Watching CNN on Apple TV is possible with a streaming service subscription. There are several services to choose from, but Sling is a good choice. You can try it out for a week for free.
For the best experience, you'll want to use a VPN to unlock the channels. There are many to choose from, including ExpressVPN. This provider has a great number of server locations worldwide. Alternatively, you could opt for Google's Chromecast.
If you're looking for a low-cost way to watch CNN without cable, then Sling TV is a good choice. You can get the service for less than $40 a month. Plus, you'll receive a host of other popular channels. Some of them include Fox News, MSNBC, and CNN.
Another option is fuboTV. FuboTV has a free trial, and it is a great way to stream CNN. They offer over 80 live TV channels.
If you want to watch CNN live on YouTube on Apple TV, then you need to be connected to a stable Internet connection. You also need to make sure that you're subscribed to a streaming service. Fortunately, there are several options for streaming this news channel.
One option is to sign up for Sling TV. For $35 a month, you'll get access to a number of cable networks. Plus, you'll get free access to the Sling TV app on Apple TV and Roku. It's easy to add other channels to your subscription as well.
Another option is to try Hulu with Live TV. You'll be able to access the full range of cable networks and Hulu's original content. This is a great way to watch CNN on YouTube.
You can also watch CNN live on Firestick, Xbox One, Chromecast, and Smart TVs. However, this method does not have as much flexibility as CNN Go.
To live stream CNN on a Smart TV, you'll need to log in to your CNN account and select "OK". Then, you'll be given the choice to cast the program to your device's home screen.
Can You Watch Regular TV with Apple TV?
Can't Cast Apple TV?


On Sunday 23 May 2010, the tide, season, Paspaley and Pinctada will combine to deliver a rare spectacle. Paspaley Beach Polo combines one of nature's greatest assets, sunset over the Kimberley coast, with the vigor and excitement of Australia's top professional polo players competing for the Paspaley Cup.
The inaugural Paspaley Beach Polo event is unique in Australia and rare in the world as Broome's iconic Cable Beach joins only a handful of exotic locations to host beach polo - Miami in the USA, Poole in the UK, Dubai in the UAE and Goa in India.
Pinctada Cable Beach, Broome's award-winning new 5-star spa resort, is the official hotel for the event and has announced a special 3-night Pinctada Polo Experience package.
o 3 nights' accommodation at Pinctada Cable Beach, staying in a Shinju Studio.
Pinctada Hotels & Resorts is also offering a Pinctada Polo Experience package at its award-winning boutique escape McAlpine House, a century old Broome villa which was originally built as the home of a Master Pearler.
The Pinctada Polo Experience packages have also been designed for guests travelling from Sydney and Melbourne to take advantage of direct flights to Broome.
Prices for the Pinctada Polo Experience start from $1,379 with options for room upgrades or extended stays. Reservations and enquiries can be made by contacting Pinctada Hotels & Resorts central reservations: E: stay@pinctada.com.au; T: 1800 PINCTADA or 1800 746 282 (Toll free within Australia) or +61 (0) 8 9193 8340.


Yesterday I finished a novel. Yes, it was a novel that was more playtime than serious attempt at great literature. But just because it was fun and not painful to write does not make it unworthy of making the effort.
In fact, writing projects like that are really the only thing that keeps me going in spite of pain, illness, and the frustrations of trying to stay alive and thrive.
So there it is, all 43,403 words of it, published for free on WordPress, accessible by this post if you bookmark it. Comments, suggestions, humiliations, and conflagrations are all welcome.


Pico Design, formed by designer Andrea Panico in 2005, explores the concept of architecture as inspiration for personal keepsakes and jewelry. This new, ecommerce website features Pico's Little Architecture collection of jewelry, its first merchandise collection under the PICO design umbrella brand. Chrein.com worked with long-time collaborator, designer Laurie Fink, and project manager Lyde Spann to create this completely customized e-store.


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Rising temperatures threaten rice yield growth: study
By David Fogarty, Climate Change Correspondent, Asia
SINGAPORE (Reuters) - Rising temperatures could slow the growth of rice production unless farmers adapt by changing management practices and switch to more heat-tolerant varieties, scientists say.
A farmer works in her rice field in Ayutthaya province, 80 km (50 miles) north of Bangkok July 7, 2010. REUTERS/Sukree Sukplang
Rice is among the world's most important crops and a staple for people in Asia and Africa, with Asia producing and consuming more than 90 percent of the world's output.
A drop in production could lead to higher prices, fears over food security and more hunger in a world with a rising human population.
A team of researchers led by Jarrod Welch of the University of California, San Diego, found that rice yields drop as night time temperatures rise over time, although the exact reasons why are not perfectly understood.
"With few exceptions, most statistical studies on temperature and rice yield have focused on the impact of daily mean temperature," the team says in the study, published online in the latest issue of the U.S. journal Proceedings of the National Academy of Sciences.
Previous research had found that higher maximum day time temperatures can be beneficial up to a point, beyond which they can be harmful. But higher daily minimum or night-time temperatures can trim or wipe out any gains.
The study is believed to be the first to look at the impact of daily maximum and minimum temperatures on irrigated rice production in farmer-managed rice fields in tropical and subtropical regions of Asia.
The team, which included researchers from the International Rice Research Institute in the Philippines and the U.N.'s Food and Agriculture Organization, studied data from 227 irrigated rice farms in six Asian countries.
The data covered six years from 1994-1999 based on a major study by IRRI on the productivity of intensively managed irrigated rice farms in China, Vietnam, the Philippines, Indonesia, Thailand and India.
"Our study is unique because it uses data collected in farmers' fields, under real-world conditions," Welch said.
Using longer-term data, the researchers found that rising temperatures during the past 25 years have already cut the yield growth rate by 10-20 percent in several locations in the study areas.
Temperature increases at night, depending on the quarter of the year and the site, were anywhere from 0.3 degrees Celsius to 0.6 deg C. on an aggregate basis.
"We see some increases in maximum temperatures but we see much more consistently increases in night-time temperature," Welch told Reuters by telephone.
This meant that future yield losses caused by higher night-time temperatures would likely outweigh any gains from slightly higher day time temperatures.
But sharply higher day time temperatures will also lead to lower yields as the plants become too stressed, IRRI and other researchers have found.
IRRI has already been developing heat-tolerant varieties. Welch said farmers in some areas could adapt by shifting the main growing season into the cooler months.
"There's also the possibility that areas where rice is currently grown becomes too warm and production shifts to cooler areas," Welch said.
But some areas such as Vietnam grow three rice crops a year in the Mekong Delta, with the highest yielding crop during the dry season. Shifting production to cooler areas could be a huge challenge.
Additional reporting by Ho Binh Minh in Hanoi; Editing by Manash Goswami


What Is The Burn Pit Registry?
If you served in Iraq or Afghanistan you want to know about the Burn Pit Registry.
The change is an attempt to speed up the process, which used to take years.
What day will that disability check be in the bank? Our VA disability payment schedule tells you.
Did you know you can always ask the VA for increased disability compensation? But be careful, it can backfire.
Nearly a third of 2 million Iraq and Afghanistan war veterans suffer from PTSD and related mental health conditions.
Veterans with the highest ratings will get about $100 extra each month.
The 2.8 increase for 2019 marks the largest cost-of-living adjustment in seven years.
The cost of living increase gives more cash to one in every five Americans.


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Multiple sclerosis (MS) clinical trials 2017-19 analytical overview
GlobalData Healthcare 9th March 2020	(Last Updated March 9th, 2020 11:25)
March is multiple sclerosis (MS) awareness month. According to the National Multiple Sclerosis Society, nearly one million people are living with the disease in the US.
Almost one million people are living with MS in the US. Credit: SewCream on Shutterstock.
March is multiple sclerosis (MS) awareness month. According to the National Multiple Sclerosis Society, nearly one million people are living with the disease in the US. It occurs when a person's immune system damages the myelin of the central nervous system, which interferes with the transmission of nerve signals to the body.
Although the cause of the disease is unknown, clinical trials are being continuously completed to find the best solution to cure the disease. With that in mind, an analysis of the MS space can be completed by using the clinical trials database of GlobalData's pharma intelligence center. In this article, GlobalData presents such an analysis.
When looking at MS clinical trials within the last three years (1 January 2017 to 31 December 2019), phase one clinical trials were the most common, representing 4.8% of the total MS trials. This was followed by phase two clinical trials, which represented 4.5%. Phase three clinical trials were next at 3.2% while phase four and phase zero were the least common at 2.7% and 0.7%, respectively. A small number of phase zero, phase one / two, phase two / three and phase three / four trials were combined with phase one, phase two, phase three and phase four trials, respectively. By overall count, the majority of MS trials in 2019 were phase one clinical trials, representing 2.4%.
Figure 1: MS clinical trials by phase, 2017–2019. Credit: GlobalData.
Ongoing, recruiting trials outnumbered trials in any other status, making up 6.0% of MS clinical trials. This was followed by trials with completed status, at 4.4% and planned trials, at 4.0%. Ongoing, not recruiting trials, suspended / withdrawn / terminated (S / W / T) trials and ongoing, recruiting by invitation trials were the three least common trial statuses.
Figure 2: MS clinical trials by status, 2017–2019. Credit: GlobalData.
A total of 1.0% of MS clinical trials are expected to begin in 2020 and 2021. When looking at them by phase, phase one and phase three tied for the most trials at 0.3%. Phase two and phase four were tied for the least common at 0.2% of clinical trials.
Figure 3: Upcoming MS clinical trials by phase. Credit: GlobalData.
Multiple Sclerosis: Global Drug Forecast and Market Analysis to 2028
SWIL Systems
ZUMEDU Secure Peer-to-Peer Video Conference Solutions for Clinical Researchers


KUWAIT: To express solidarity with the people of Kashmir for their courage and continued struggle for the right of self-determination, a special ceremony was held on Thursday, Feb 05 at Pakistan Embassy in Kuwait, with large number of people from Pakistani community and officials of the embassy participated.
The ceremony began with recitation from the Holy Quran and Anthem of Pakistan. The messages of the President and the Prime Minister of Pakistan were read out to the participants. These messages reaffirmed Pakistan's resolve to stand by Kashmiri brothers and sisters in their legitimate struggle against foreign occupation.
The Ambassador H.E Mohammad Aslam Khan, in his address, highlighted the significance of the Kashmir Solidarity Day and Pakistan's efforts to secure a solution to the long-standing Kashmir dispute. He stressed upon the support of the international community especially the Muslim countries in resolving the Kashmir dispute as per UN resolutions. Pakistan was committed to extending full moral, diplomatic and political support to the Kashmiri people till the realization of their right to self-determination, he added.
A documentary film, highlighting the peaceful protests of the unarmed Kashmiris against the occupation forces was also shown to the audience.
The ceremony ended with collective prayers for the success of the Kashmir struggle and peace and prosperity of Pakistan.


Christmas Wish For our Alsatian.
Hi friends! It's been a long span of time that I last updated my blog. Christmas is right around the corner and I just wanted to know how's it going with your Christmas preparation.
All I want this Christmas is that all the German Shepherd Dogs and all the other dogs in the world my find The Earth to be a good place to live in. May their owners find them in absolutely good health and happy life.


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The Most 'Spiritual' Swami In America
File under: The Siddhi of PR and Real True Gurus
Today while visiting our tribe.net account, we came upon this ad:
The most spiritual magazine on the market today. That's saying a lot. First that magazines can be spiritual, and then that this magazine is the most of that, whatever that is.
When we went to the website of the "most spiritual magazine on the market," we learned that it's the effort of one Prabhushri Swami Amar Jyoti. We went straight to his site with a glee one has when they are about to skewer the most spiritual swami in America. But then we found ourselves stopped dead cold by his picture.
The guy just doesn't look like a flimflamming big-time guru. Furthermore, he's flown under our radar for the 10 years we've been gurubusting. Maybe that says more about what we don't know about gurudom in America, but we like to think it's because the Swami just doesn't feel the need to have a press release-spitting PR department on the case.
But he is sure towing the party line as far as the Hindu traditions of gurudom are concerned. We have plenty of problems with that, but it's not necessarily an indication that the Swami is false in any way, just a product of his upbringing. And we do like this quote on Swami's bio page:
Things don't happen in spite of us. You and I are as important as anyone else and as responsible as anyone else. Whatever you and I do, speak or think is contributing to the entire energy of the world.
Notice how he includes himself when speaking about us. Rather than being about him, or those he's working to acquire as devotees, it's about all of us together. There's a whole bunch more quotes here. We've got to admit we liked every one we read. He may be way too old school for us, but perhaps he's a best case scenario for that particular configuration.
We're going to cautiously embrace the idea that Swami Amar Jyoti is a real, true guru and see what happens. Anyone with any opinions to the contrary are invited to share them with us in the comments section.
Update: From a reader:
He's flown under your radar because he's been dead for five years. But while he was alive, there were womanizing rumors.
Well, perhaps he wasn't quite the most spiritual swami in America to begin with.
Jody,
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Justia › US Law › Case Law › Federal Courts › Courts of Appeals › Fifth Circuit › 1934 › Mississippi Power & Light Co. v. Whitescarver
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Mississippi Power & Light Co. v. Whitescarver, 68 F.2d 928 (5th Cir. 1934)
U.S. Court of Appeals for the Fifth Circuit - 68 F.2d 928 (5th Cir. 1934)
68 F.2d 928 (1934)
MISSISSIPPI POWER & LIGHT CO.
WHITESCARVER et al.
Circuit Court of Appeals, Fifth Circuit.
February 2, 1934.
Rehearing Denied March 2, 1934.
Marcellus Green, Garner Wynn Green, and Forrest B. Jackson, all of Jackson, Miss., and R. L. Dent, of Vicksburg, Miss., for appellant.
J. F. Barbour, of Yazoo City, Miss., for appellees.
Before BRYAN, SIBLEY, and HUTCHESON, Circuit Judges.
SIBLEY, Circuit Judge.
On this appeal from a recovery of $7,500 for the negligent electrocution of one Whitescarver, the Mississippi Power & Light Company assigns as error the exclusion as evidence of an extract from a book and the refusal to direct the verdict in its favor. The declaration alleged as negligence among other things that the company maintained its power wires, carrying 13,000 volts, at an insufficient height where the death occurred, and that its representatives who were present just beforehand and knew what Whitescarver was about to do and the danger in it did not stop or warn him, and he, being ignorant of the danger, brought a metal pole which he was erecting against or near a wire and was killed by electricity from it. The outline of the evidence is as follows: Three power lines, bare and carrying 13,000 volts of electricity, were strung by virtue of a public franchise on common looking poles along the *929 paved highway at the line of the adjoining fields and at a height between poles of 19 feet and 4 inches from the ground at a locality about one-half mile from the edge of the city of Leland. In the city and up to a few hundred feet from this place the poles were higher and were again higher just beyond it. A few weeks before Whitescarver's death the land in the vicinity, formerly a cotton field, had been cut up into lots and was auctioned off, and one Carollo had bought lots adjoining the highway and on them was building a home and a gasoline filling station. A week before the death of Whitescarver, Carollo had requested the Power & Light Company to arrange connections to light these buildings, and on the day previous to the death two linesmen were sent who strung the light wires to the buildings and installed on a pole near the filling station a transformer to reduce the voltage of the current for the lights. On the fatal morning, before these men left, Whitescarver, who was an employee of an oil company, arrived with a metal pole which, with the advertising sign at its top, was over 22 feet long, and he began digging a hole in which to plant the pole on the edge of Carollo's lot directly under the wires. This was seen by the linesmen of the company, and one of them says he gave Whitescarver warning that the wires carried a heavy voltage and were dangerous. The other testified he neither gave nor heard a warning, but he was in the filing station part of the time and it might have been given without his hearing it. Others working near at hand for Carollo say no warning was given in their hearing. A negro painter, Graves, testified that Whitescarver came to him at the rear of the filling station to borrow a ladder to use in raising the pole and asked him to help, and that he refused, stating that the wires were dangerous. He says he followed Whitescarver to the spot, however, and saw the occurrence. Carollo testifies that he got the ladder and Graves said nothing to him, but stayed behind the filling station where he was painting. Several others testify that Graves was painting there and did not come to the front until after the occurrence and then asked what had happened. Carollo and all the others say they were ignorant that the wires carried a heavy voltage and were dangerous or they would not have helped raise the pole, and that just before raising it one of them asked Whitescarver if there was danger in touching the wire and he answered that it would only tickle them if touched. As they all were raising the pole to place it in its hole, it touched a wire or came so near it that the electricity leaped to it. Whitescarver and another were instantly killed and three were shocked and burned. There was much varying testimony as to the usual and proper height for high voltage wires, that for the plaintiffs being that 22 feet was the minimum along rural highways, and that for the company placing the safe minimum at 18 feet. All agreed that they should be higher where there were buildings or other likelihood of their being touched. The company's superintendent in charge of these lines testified that he sent the two linesmen to put in the transformer and that if they saw any construction going on near a wire and that the wire was too close to the ground for safety, it would be their duty to report it, but not to raise the wire, and their instructions were to remain there until someone should come to help them clear up a hazardous condition.
On this testimony the court properly refused to instruct the jury to find for the defendant. He did tell them that Whitescarver was negligent, and that they must reduce the recovery, if any, accordingly, but left it to them to decide whether the company was also negligent and its negligence a proximate cause of the injury, and whether or not Whitescarver was warned, and, if so, whether his own rashness was not the sole cause of his death. Section 511 of Mississippi Code of 1930 provides that the negligence of the person injured shall not bar a recovery, but the damages shall be diminished by the jury in proportion to the amount of negligence attributable to him. Section 512 is that all questions of negligence and contributory negligence shall be for the jury to determine. We agree with appellant's contention that the latter section is not binding in a federal court, but deals with the functions of judge and jury as to which federal courts have their own organization and as to which state law is without effect. Herron v. Southern Pacific Co., 283 U.S. 91, 51 S. Ct. 383, 75 L. Ed. 857. Section 511, on the contrary, is a part of the substantive law of the state under which the homicide occurred, and by which the case concerning it must be tried. 28 USCA § 275. The appellant, therefore, was not entitled to a verdict because the judge held Whitescarver guilty of negligence. The evidence does not demand a verdict that he alone was to blame. It is not established beyond dispute that he knew, or was warned, that the wires were dangerous. The negro painter is flatly contradicted on many material matters by several witnesses, and the *930 jury might find him to be impeached. The lineman who says he gave warning is not disinterested, but exculpates himself as to a transaction with a dead man. He did not in fact appear as a witness and could not be cross-examined, but a written statement of what he would testify if present was read by agreement. He gives no details of place and persons present when he gave the warning before leaving, but indicates that one Bussey was there. Bussey testifies that he was working with Whitescarver all the time except for an absence of twenty-five minutes, and did not hear any warning and did not know that the wires carried a high voltage. None of the others heard it. The jury were not bound to believe it was given, for it is almost unbelievable that Whitescarver would afterwards have undertaken to raise among such wires a metal pole which was longer than the wires were high, or would have assured his helpers as he did that there was no danger. Nevertheless we agree with the judge that he was, if ignorant, still negligent in not ascertaining what the bare wires he was about to work among held in the way of danger. Touching the negligence of the company we do not think the height at which they were maintained and the question of what danger in general ought to have been anticipated is of greatest importance in this case. Their height was known to Whitescarver. His impending effort to raise a pole of greater length than their height right under them was known to the linesmen before they left. They knew the wires were dangerous and had instructions to remain with a hazardous situation until the hazard was removed. They left without taking any steps to avoid an injury, and as the jury might find, even without a warning of the danger. The dangerous charge of electricity was the efficient cause of the death. The jury might well find that negligence on the part of the company's employees in not guarding against a peril not merely possible but developing before their eyes contributed proximately to produce the injury along with the negligence of Whitescarver in raising the metal pole among the wires without ascertaining their character. The verdict appears to be one for reduced damages.
Error is assigned on the exclusion as evidence of "National Electric Safety Code, 4th Ed., dated Dec. 31, 1926, issued by the United States Department of Commerce, Bureau of Standards, as shown by transcript pages 118-120 and especially page 100, Table 1, showing the minimum vertical clearance of wires above ground or rails for electrical construction." The full substance of the rejected evidence is not quoted in the assignment as required by our rule XI. The pages of the transcript referred to show that page 101 instead of page 100 was offered, and there is no setting forth there of the evidence. The judge has ordered sent up as an original document what purports to be the code referred to, but we greatly doubt the propriety of thus perfecting a bill of exceptions. We might well refuse to consider the assignment. Price v. United States (C. C. A.) 68 F.(2d) 133; Florida Railroad Co. v. Smith, 21 Wall. 255, 22 L. Ed. 513. But both parties seem to understand that what was offered was a single item purporting to show that for wires carrying 750 to 15,000 volts the vertical minimum clearance along roads in rural districts should be 18 feet. An expert witness was on the stand when the book was offered, and testified that in his opinion a minimum of 18 feet was permissible. He identified the book as one issued by the Bureau of Standards, "but the Government did not put its official stamp on it." He did not refer to it as supporting his opinion, or testify that it was accepted by electrical experts as standard. The book itself was offered as evidence in chief. It is conceded that the Bureau of Standards has no power to regulate the placing of electric wires, and that the book has no compulsive force. It was issued under permission of 15 USCA § 274, as "Information which may be of value to the public." No law required it. It represents merely the opinion of the compilers, and its preface states that as to many matters there are conflicting views, and that especially many changes had been made in this edition touching line construction and that there would be future growth and development, and criticism is invited. It thus appears from the book itself what we should have known anyway, that it deals not with an exact science or mathematical or factual certainties, but with a controversial and developing science in which opinions may vary and experience work great changes. Books in such a field are like medical works rather than like almanacs, mathematical tables, approved histories, census compilations or weather reports. They are at last only the expert opinions of the authors, delivered not under oath nor subject to cross-examination, without opportunity to qualify or explain them, and really without certainty that the author still adheres to the opinions expressed when the book was written. The leading case *931 in America for rejecting scientific books as primary evidence is Ashworth v. Kittridge, 12 Cush. (Mass.) 193, 59 Am. Dec. 178. The rule is established in Mississippi, Tucker v. Donald, 60 Miss. 460, 45 Am. Rep. 416, and generally elsewhere except in Alabama. Union Pacific R. R. v. Yates (C. C. A.) 79 F. 584, 40 L. R. A. 553; 10 R. C. L., Evidence, § 364; 22 C. J., Evidence, 829; note, 19 Ann. Cas. 999. There was no error in rejecting the evidence offered.
Judgment affirmed.
of Fifth Circuit opinions.


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Nvidia Posts Specs Of GeForce 9M Series
By Wolfgang Gruener published 8 February 08
Santa Clara (CA) - Nvidia's next-generation mobile graphics aren't officially announced yet, but curious minds can already find some technical information about the new GPUs on Nvidia's website.
The company has listed brief specifications for the 9300M G as well as the 9500M GS. The lower-end will get you 16 stream processors, a core clock of 400 MHz and a memory clock of 600 MHz. The chip can be combined with up to 256 MB memory. Step up to the 9500M and then you'll receive 32 stream processors, a 475 core clock and a 700 Memory clock with up to 512 MB of buffer. If you look closely, you will notice that these specifications exactly mirror those of the 8400M GS and 8600M GT.
Asus apparently couldn't wait for Nvidia to announce these new GPUs and today unveiled two notebooks integrating these chips. The 9300M G replaces the 8400M in the company's 12.1" U6S model; the M51SN 15.4 notebook is available with the 9500M GS GPU.
Desktop RTX 3060 Ti With GA103 GPU Incoming Says AIDA64