Concept school canteens. Freeflow system.
We want, that many children and young people take at least 1 x daily properly prepared food. We cook every day for many children in a very high quality.
We love children, our approach only makes sense if the food is also good and high quality later after pre-school. This works especially when many kitchens has the same principle. Our experience shows that the older the children, it is becoming increasingly important, not anonymous to deliver the food but directly with the students because food is very social and private. That is the reason why we have opted for a fresh cooking approach on the ground at each school.
For schools offer full-day classes or in which students eat regularly, we recommend our "free flow" system. With this system, you pay the entrance to the cafeteria and then you can freely choose between the following components preorder without food.
In addition, there is pre-portioned salad at the local food bank, too.
This system ensures everyone can find something, so it is particularly suitable for large catering units.


Ecommerce Solutions: How To Conduct Email Marketing Campaign - Angela's Blog!
Email marketing is considered the best choice for reaching targeted customers and making relationships with the clients. It is considered one of the highest return on investment (ROI) across all online marketing methods. Given are some valuable tips about email marketing.
It might be possible that your mailing list includes many contacts that want to subscribe to your services but asking for their consent. You must email them an introductory message that informs them that they will receive data if they opt in a better way of building a relationship.
Experts are of the view that, it is better to write declaration on every form that the company will not share personal information for other purposes. In this way, you can bet the trust of your users. Email marketing is considered one of the confidential Dubai ecommerce solutions.
You must provide free benefits to your subscribers by organizing a contest. This will make your email marketing campaign more effective. Inform them completely; so that they know that they will get free service they subscribe to receive your company's newsletter.
Once the user has agreed to receive your email, you must try to win their hearts. You must send them a confirmation letter that contains a thank you page. Try to ensure the subscribers that they will get user experience.
It is better to understand the thought of your unsubscribers. You must ask them what kind of services they want? Take their feedback and try to utilize it in your next campaign. The opinion of unsubscribers will teach you a lot to better your services.
If you have a lot of subscribers, you need to select your best users. If you have the policy to send specific number of emails per month or week, so you must act accordingly. Don't send previous emails to your subscribers, so in this way, you will lose their confidence.
You can use social media sites to promote your products. You can use Twitter, Facebook, Instagram, and other sites to promote an ebook to your followers. You can add thank you pages on your Facebook page that express gratitude.
Email marketing provides best Dubai ecommerce solutions that are used by large to small businesses globally. With an increasing number of strategies and tools, you can now make mailing list without any hassle. You must listen to your customers, their likes and dislikes.


For its newsletter subscribers only, newegg offers the Dolica STC-100 Lightweight Tripod and Ball-head Monopod Combo for $39.99. Coupon code "EMCJKHK77" cuts it to $19.99 with free shipping. The tripod features a 3-way pan head, quick-release plate, bubble level, maximum height of 68", and more. The monopod features an integrated ball head, hand strap, maximum height of 65", and more. Coupon expires October 22.
Don't forget, if you're purchasing from Newegg, make sure to use Mr. Rebates Cashback and get 1% cashback. For more information about Mr. Rebates, go HERE.


text:
Q: Let $T$ be a theory of Abelian groups where every element has order 2 find complete theory include T This question is from Marker's book .
Let $T$ be a theory of Abelian groups where every element has order 2 . Show that it is not complete . Find $T' \supset T $ a complete theory with the same infinite model as $T$.
I showed it is not complete but i can't find  $T'$.I don't want whole answer just give me clue .

A: HINT:
Note that every such group $G$ is a vector space over $\Bbb F_2$ (the field of two elements). Add to $T$ the sentences "There are at least $n$ elements in the universe", for every $n\in\Bbb N$. Then $T'$ is the theory of an infinite dimensional vector space over $\Bbb F_2$.

redpajama_set_name: RedPajamaStackExchange


W.O.P.: Women of Power is an Award-Winning Gospel Radio Show that combines Hot Topics, great interviews with good gospel music.
Hosted by Kasha Hunt, a businesswoman, Producer and Host of television shows, a Playwright, Author, Motivational Speaker and Minister of the Gospel. Kasha is known as "Raw Truth".
Join us for an exciting show every Friday Night in the Grey Bowl from 8pm-9pm CST.


text:
small Ceramic Dog Bowl: Weeping Plum
Decrease quantity for small Ceramic Dog Bowl: Weeping Plum
Increase quantity for small Ceramic Dog Bowl: Weeping Plum
Brightly Coloured Homeware & Pet Dishes
Angela originally came from Ballymena, but moved to England and then Scotland before returning home to N Ireland after 30 years.
Angela started making pottery in 1992 in Leeds and immediately fell in love with creating using clay. After a break to concentrate on being 'Mum', Angela established her own small studio in North Antrim where she gets much inspiration from the beautiful countryside and beaches.
Angela has a great love for animals, especially dogs, having 2 adopted Bedlington terriers, Susie and Millie who keep her company in the studio. They are both rescue dogs. Millie came from the meat trade in China where she was rescued by a wonderful organisation founded by 3 women - 1 is from Cork, 1 from England and one from Australia. This led to how Angela started pottery again, making dog bowls for her own dogs and pretty soon she was receiving orders from others.
Angela says "It's so relaxing creating on my pottery wheel, listening to an audio book with my 2 dogs. The perfect way to destress and unwind".
Hand Made Ceramic Dog Bowl

redpajama_set_name: RedPajamaCommonCrawl


If you've been following along for any amount of time, you probably know that we are new homeowners. With stark white walls. And hardly any furniture. Which means…I have to stop myself from running to Target every payday.
But instead? I'll make a plan.
Welcome to Project Home 2014. Our list of To Do's for the year!
And I need to put some photos in those frames!
This corner has got me stumped. It's a small little space back there, which makes it tough. I'm open to any and all suggestions.
It needs some paint, some shelves, some wall art…oh and a desk. Minor detail.
I'd also like to do this bathroom. It needs some major love. And some major light. It's hard doing your makeup in a bathroom when you can only see a tiny bit of your face.
And last, if the budget allows, I'd like to start on our kitchen. Our kitchen will probably end up being our Project Home in 2015 AND 2016. We'd like to put in new floors and cabinets, add a dry bar and a wine fridge, install granite countertops and new light fixtures…oh and put up new barn door wainscoting. Soooooooo possibly even Project Home 2017.
And a Farmhouse Table is one of my must-haves. This table is nice, but we need something a bit bigger so that Trenton doesn't have to sit on the Exercise Ball for every meal.
Kids don't need to go to college, right?
A couple of suggestions for your small bedroom corner as we have one as well – we at one time had a fake tree, which we have since moved to our family room – http://tinypic.com/r/xqhvtu/5. If I had a second one just like it though I would put it back in our bedroom corner. I loved it there, but love it more in my family room. 🙂 Other suggestion would be a simple tall lamp – (example of what I am referring to in which we have in our bonus area – http://tinypic.com/r/rtlx5j/5). Love what you have done with your place already though!!
Such great ideas Jenn! I like the lamp…we need more light in that corner!


text:
Turkey Run Golf Course
Dan Cass likes to golf. The local entrepreneur and former restaurant owner, realizing the Arcade area was in need of a country club, saw opportunity when Turkey Run went up for sale in 2015. Combining the two things he loved - golf and small business - made the purchase one he doesn't regret. Now, with a reinvigorated attitude and a brand-new clubhouse, Turkey Run has become a staple in the local golf and restaurant scene.
Built in 1987, Turkey Run had a reputation as a short, fun track. The value of the greens fees matched the course - you wouldn't pay top dollar, but you also wouldn't expect Augusta. A small building greeted golfers to check-in and head out, but after the round, you'd pack up and go home.
When Cass bought the name and adjacent 95 acres of land, he had a grander vision. Construction began soon after on a new clubhouse and restaurant that could offer more than just post-round drinks. Completed in July of 2018, the clubhouse offers bar and dinner seating, a wraparound porch for drinks outside, and the ability to host large parties and tournaments.
"It's a full-service bar & grille," Cass said. "Since its completion, we've hosted bridal and baby showers, birthday parties, banquets, Christmas parties … you name it. There are a multitude of clubs that meet here twice a month, and we're expecting more for the upcoming summer. It's been unexpected, but it just went to show that there was a need for something like this in the community."
Typically, golf courses and their clubhouses shut down for the winter months. But this past winter, Cass and Turkey Run decided to stay open throughout the cold. A cornhole league in November and December, Wednesday wing nights and specials through the week kept them busy. Plus, it helped keep Turkey Run in mind for potential new members.
"It's still a little early, but I've taken in way more memberships than previous years, and I think a lot of that has to do with the clubhouse," Cass said. "I'm expecting more memberships once the weather breaks. We've substantially increased the size of our men's and ladies' leagues."
While the club hasn't changed any of the course layout (as of yet), they've taken on a new commitment to maintenance and upkeep. Mowing, cleaning out ditches, taking care of the greens and other general course work has allowed for a much better golf experience.
"The greens and fairways are immaculate," Cass said. "We've really done a nice job of making sure the course stays in good shape. We've thrown around some ideas on changing a few holes, but that's down the road. For this year, we're going to continue our maintenance commitment, blacktop the lot around the clubhouse and make the landscaping look a little nicer. It's all of those little things that people notice."
Turkey Run offers single, couple and senior military membership options. Early memberships receive 10% off menu items in the clubhouse, while current purchases get you 5% off. You can book your tee time at the website, and Cass says they're looking into more 3rd party apps to make it easier for golfers to book.
"It's definitely a new look for the course," he said. "It's maintained, the greens and fairways are immaculate, and there's always something going on at the clubhouse."
For more information on Turkey Run, head to www.turkeyrunarcade.com or find them on Facebook at Turkey Run Golf Course.
SK8EVL
With help from the Tony Hawk Foundation, Ellicottville begins effort to build a skatepark. Read more
Ellicottville Paddle Festival
Adventure Bound onthefly's 4th annual Paddle Festival returns to Spruce Lake June 22nd & 23rd. Read more
EVGV Trail
After years of intensive planning, exceptional dedication and community support, the Ellicottville Great Valley Trail looks to begin building Read more
Cardinal Hills Golf Course
A new event center, exceptional junior programs and some of the best scenery in the county makes Cardinal Hills a WNY golf gem. Read more
Zippo Open: Sarah Blaisdell Dorn Memorial Benefits McKean County SPCA
One of the most prominent charitable golf outings in the area returns to The Pennhills Club on Saturday, June 1st. The Zippo Open: Sarah Dorn Blaisdell Memorial raises money for the McKean County SPCA, combining a rich history with generous donations and sponsorships. Started in 1963, the memorial continues to prove successful in the Bradford golf circuit. Read more
Dan Cass likes to golf. The local entrepreneur and former restaurant owner, realizing the Arcade area was in need of a country club, saw opportunity when Turkey Run went up for sale in 2015. Combining the two things he loved - golf and small business - made the purchase one he doesn't regret. Now, with a reinvigorated attitude and a brand-new clubhouse, Turkey Run has become a staple in the local golf and restaurant scene. Read more
The Waters of Cattaraugus County
By Cattaraugus County Tourism
Time to hit the water ... where to go? Read more
Mission Monday
Concord Crest Golf Course donates to local charities Read more
By Linda Devlin
National Get Outdoors Day is June 9th ... what adventure will you find? Read more
Patriot Golf Day
Local golf courses raise money for Folds of Honor Read more


text:
Home News Company News Sharpham Park ploughs cash into spelt mill
Sharpham Park ploughs cash into spelt mill
Jane Wolfe
UK organic spelt producer Sharpham Park has made a significant investment in its spelt mill, located on its Somerset farm.
The mill has seen its capacity soar over the last ten years, says the company, and as a result the cash injection was needed to ensure continued high quality milling to meet predicted growth.
Sharpham Park founder Roger Saul (pictured) says: "We are investing in excess of £50,000 in the mill's grain cleaning and aspiration system which will ensure that our flour continues to be of the highest quality possible as well as helping us to significantly reduce our waste levels. Our mill output has quadrupled over the last ten years and this investment will allow us to continue to grow productivity at the mill.
Our mill output has quadrupled over the last ten years and this investment will allow us to continue to grow productivity at the mill.
"As a result of the current industry trends for plant-based foods, vegetarianism and veganism, as well as consumers choosing spelt for its health benefits, we are seeing a significant increase in demand for spelt from our stockists. Due to the more favourable exchange rates we're finding our export sales are growing much faster than predicted and this investment will put us ahead of the game and make sure we're ready to meet future milling challenges."
Sharpham Park offers a number of spelt-based products including flours, cereals and grains.
roger saul
sharpham park
Previous articleA silent night for babies from Green People
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Jane Wolfe has worked in journalism since leaving University with a BA (Hons) in English in 1991, covering industries as diverse as energy, broadcasting, wellbeing and animal welfare. She first became part of the Natural Products News team in 1998 as a sub editor and freelance journalist before relocating to Greece in 2004. In 2013 she returned to the magazine as assistant editor, then deputy editor.


text:
Q: Powershell Access Azure DevOps Secret Variables I am attempting to read an Azure DevOps secret variable from a Powershell pipeline script. The variable looks like this within Azure:

I've attempted to access the secret variable both as a param such as
[CmdletBinding()]
Param (
    $SecurePassword = $env:Password
)

and simply as an environment variable such as
$SecurePassword = $env:Password

Unfortunately the variable continues to appear null using either method.

I have no issue accessing non-secret variables. Any help would be greatly appreciated.
---------------------------------------- EDIT ----------------------------------------
I found documentation here stating that secrets are available to scripts within the pipeline if explicitly mapped in the environment section of the task.

I've updated my Powershell task and attempted to map the variable as both $(Password) and Password without any luck.

Mapping $(Password) as above reveals the string hidden behind asterisks.

A: We had a requirement to create a new project in Azure DevOps and needed to migrate all of the pipelines to the new project.  Lo and behold, no one knew all of the secrets, and export / import doesn't accomplish this.
I wrote a script to output all environment variables into an "Extensions" tab next to the build summary.  It's formatted and everything.
The key to outputting the secret is by altering the string by inserting the '<-eliminate->' phrase within the secret value and saving to a file.  Once the file is created, we then remove all instances of the string '<-eliminate->', save the file, and there it sits as an extension page to the build summary.
I would like to somehow find All secrets dynamically, but for now manually defining the variable name does the trick.
I re-formatted for this post and removed proprietary info, please let me know if it's broken :)
function GetSecretLength ($secretVar){
     $i = 0;
     while($true){
          try {
               $secretVar.substring(0,$i)|out-null
          } catch {
               break
          };
          $i++;
     }
     if ($i -le 1) { return 1 }
     else { return $i-1 };
}
function GetSecret($secret){
     $length = GetSecretLength($secret);
     if ($length -ge 2) {
        return $secret.substring(0,$length-1 )+"<-eliminate->"+$secret.substring($length-1,1)
    } elseif ($length -eq 1) {
        return $secret+"<-eliminate->"
    } else {
        return ""
    }
}

$var = (gci env:*).GetEnumerator() | Sort-Object Name
$out = ""

Foreach ($v in $var) { $out = $out + "`t{0,-28} = {1,-28}`n" -f $v.Name, (GetSecret($v.Value)) }

$fileName = "$env:BUILD_ARTIFACTSTAGINGDIRECTORY\build-variables.md"
write-output "dump variables on $fileName"
set-content $fileName $out

write-output "##vso[task.addattachment type=Distributedtask.Core.Summary;name=Environment Variables;]$fileName"

((Get-Content -path $fileName -Raw) -replace '<-eliminate->', '') | Set-Content -Path $fileName

You have to add the secret variables that you want into the "Environment Variables" of the Powershell task:

You end up with this pretty tab:

A: Why not just store the password in a keyvault as a secret? then there are azure commands for accessing the secret, and avoid all this. Heck, we generate random passwords, store them in keyvaults, then access the contents in the appropriate resource, without ever needing to expose the decrypted secret in a powershell command, like in an ARM template for an azure sql server database.
I know this doesn't solve your initial question, but it is a workaround that does work.


text:
EXCLUSIVE: Fabio Issues "Challenge" to Old Old Spice Guy Isaiah Mustafa [VIDEO]
By Todd Wasserman 2011-07-25 07:00:44 UTC
A lot of Old Spice fans have been wondering whether last week's round of new ads featuring Fabio meant that the old Old Spice guy, Isaiah Mustafa, is out.
Good news for Mustafa fans: A source at Procter & Gamble says Mustafa is still involved and, in fact, will be answering this "challenge" that Fabio will put forth on Monday. Mustafa will respond around 1 p.m. EST.
The plotline is the answer to the question in advertising circles: "What will Old Spice do next?" After unprecedented success with Mustafa's "Smell like a man, man" campaign from ad agency Wieden + Kennedy that hit in 2010, the brand has mostly just tweaked the campaign. Though a replacement for Mustafa has appeared in foreign markets, in the U.S., things haven't really evolved. Until now, that is.
Keep an eye out for more silliness on Monday. You don't think Mustafa's going to back down from Fabio's challenge, do you?
Topics: Advertising, Business, Marketing, old spice, Twitter, wieden & kennedy, YouTube


text:
Mehfil has always been a centre of Socio-religious programs, where social issues have been addressed with sincerity and religious gatherings are held with responsibility.
The year remained ever so challenging, as all the activities were influenced by the concerns of security for momineens of Karachi, it became imperative to gear up our efforts to make all the events successful.
The Managing Committee of Mehfil-e-Murtaza, invited (for the second time) Maulana Kumail Mehdavi to recite in Muharram. The Ladies Majalis were addressed by Zakira Zakia Ghulam Mehdi.
The current Managing Committee elected for the term of 2009-2012 revived the concept of Sub-committees, who under their convener became responsible for conducting their assignments as per the scope of the sub & working committees, and keeping in view the policies conveyed by the Managing Committee.
The volunteers considered to be the backbone of any institution, have made us proud, as their services are recognized by both momineens in Pakistan and Institutions representing Khoja's throughout the Globe. New recruitments were made through the year, and outstanding performances were appreciated at different platforms to encourage other youngsters.
The regular activities committee is responsible for managing the daily affairs of the Masjid and Imambargah. Also responsible to monitor the institutions under the patronage of Mehfil-e-Murtaza. All Wiladat & Shahadat programs are comprehensively organized by this committee. The Hussaini Society Madressah is also being looked after by the sub-committee, under the chairmanship of Mr. Shaukat Moolo.
Keyword: Time Management
The committee was originally formed to plan, organize & implement the Ittehad Bain ul Muslimeen Week, held on the Birth Anniversary of Rasool-e-Khuda (S.A.W) on 12th and 17th Rabi-ul-Awal, every year. But can also arrange other programs recognized as, of such magnitude.
Keyword: Unity
Conveners Annual Report
The first ever program of Jashan-e-Miladun Nabi (S.A.W.) and Ittehad-e-Bainul Muslimeen was introduced in Karachi in 1995 where scholars from different Islamic schools of thought within Pakistan and from overseas were invited to participate on 12th and 17th (Shab) Rabiul Awwal. The programme has been regularly held every year since then and has gone from strength to strength. We remain hopeful that our innovative efforts have promoted religious tolerance and understanding in these difficult times.
A closing meeting of the Organizing Committee and the Media Committee was held on 13.03.2011 (to review the events and identify areas of improvements) with respect to Jashn-e-Miladun Nabi (S.A.W.) and Ittehad-e-Bainul Muslimeen 1432/2011 which was successfully held on 15.02.2011 and 20.02.2011.
As you are aware that Organizing Committee used to start preparation for this program after Ashura. However, for the first time the preparation for the 19th program 1433/2012 has been started much earlier in order to make further improvements. In this regard first preparatory meeting was held in the month of Zilqad on 06.10.2011. Following are the few new ideas which were identified in this regard:
1) Preparation of SOP for future events and bifurcate responsibilities.
2) How to enhance Sunni participation whether on stage, or in the audience, or on the rostrum.
3) To see alternatives to traditional Maulanas e.g. Scholars as well as speakers from abroad e.g. India.
4) To see venue change to provide neutrality and comfort to non-Shias.
5) To arrange talk show format on 17th Rabiul Awwal and only Naat on 12th Rabiul Awwal
The primary responsibility of the Committee was to ensure the daily maintenance of Mehfil-e-Murtaza premises including outside the boundary wall front and back for cleaning, repairs and maintenance. The convener and his team have been successful in reducing the cost of overhead expenses by vigilance and prompt actions. They are also responsible for ensuring quality of services from the paid staff.
Keyword: Cleanliness
As the name suggests the committee looks after the financial matters of the institution. A comprehensive methodology was developed by Finance Committee to organize the collections of donations, make investments in short terms and long terms, and ensure availability of funds for daily, weekly and monthly programs. The committee was also responsible for introducing 'support your mehfil' which was very successful.
Keyword: Accuracy
As mentioned earlier, the security arrangements remained the prime concern in all events of the year, specially Ramazan & Muharram.
Keyword: Vigilance
Ghusul / Kafan
29 mayats were given ghusal & kafan at Mehfil-e-Murtaza Ghusal Khana during the year 2011. Besides the committee also arranged a couple of training sessions for members & youths of the community, through renowned Zakirs & Zakiras. The death registration form was also 'modified' to have more details for record purpose. The ambulance remained available for transportation from Masjid to Graveyard to most of the above cases.
Keyword: Responsibility
The committee introduced the SMS & E-mail services for convenience of members and for all those who wanted to use the service, the response of which was also very positive from the community. The New Website of Mehfil-e-Murtaza will soon be launched (Probably January 2012), which will have all information about Mehfil activities & will invite feedback and suggestions from its viewers. Mehfil Majalis & Milads are seen live on Internet for the last few years. Besides Dua / Aamal Books are arranged by the committee as per requirement, for respective programs.
Keyword: Accessibility
OVERSEAS GUESTS
The President of World Federation Dr. Asghar Moledina visited our institution twice this year, and showed his satisfaction over the work carried on by the management. His interaction with people of the community during his visits reflected the interest and committement of World Federation towards our members.
Ordinary: 84
Patron Members: 09
Life Members: 228
The Managing Committee of Mehfil-e-Murtaza appreciates and thanks all its members for their continuous support and guidance, their donations, their time and most of all their forbearance, enabling and encouraging us to move forward.


text:
Q: how to add date header to httpGet I am currently using HttpGet(apache) method to make a request to a web service.
When I was calling the server it was giving me this error:
"The difference between the request time and the server time is too large"
Then I came to know that the server needs to have the request in GMT so I did add accordingly an header (addHeader) to do the same. But still I have the same issue.
Any thoughts/ideas?
some code:
    final String url = "ip address";
    final HttpGet request = new HttpGet(url);
    final ArrayList<NameValuePair> nameValues = new ArrayList<NameValuePair>();
    nameValues.add(new BasicNameValuePair("Authorization", "XXXX"));
    nameValues.add(new BasicNameValuePair("date", "Fri, 19 Aug 2011 22:39:13 GMT"));
    for (final NameValuePair h : nameValues)
    {
        request.addHeader(h.getName(), h.getValue());
    }
    final HttpClient client = new DefaultHttpClient();
    HttpResponse httpResponse;
    try
    {
        httpResponse = client.execute(request);
        responseCode = httpResponse.getStatusLine().getStatusCode();
        message = httpResponse.getStatusLine().getReasonPhrase();
        final HttpEntity entity = httpResponse.getEntity();

        if (entity != null)
        {
            final InputStream instream = entity.getContent();
            response = convertStreamToString(instream);
            instream.close();
        }
    }
    catch (final Exception e)
    {
    }

A: I was able to get it resolved.
I found out that the server has being set to GMT while I was calling with CST.


Summer is among us, and with that comes the undoubted vibe of ease. The last thing you want is to look uptight. So here's a few tips on how to upgrade your suit and keep it relaxed.
1. Do away with the tie, and opt for fun pocket squares from Edward Armah, Hook and Albert, and Chelsey. Generally, when keeping the suit simple, pick out a colorful pocket square, it'll add the perfect touch of elegance.
No one wants to swelter, so lessen the fabric load and choose options such as crisp linen from Report collection, Vilebrequin, and Sansone. These breathable fabrics will keep you cool without compromising your appearance.
As well as heavier fabrics, thick lining can lead to feeling more heat than desired while you're in your suit or sport coat. Look for unlined or partially lined suits or sport coats from Canali,LBM, or Talbott. This allows for air to penetrate your jacket, to ensure you stay cool all summer.


Help your child have a good night sleep with This Orthopedic coil mattress. Made with 200 temper steel coils it ensures the maximum support and quality you need in a mattress. The waterproof quilting ensures no leaks will seep inside.
Fabric: Select cover may come in different shades of fabric than displayed.


IDI, Inc. (NYSE MKT: IDI), an information solutions provider, today announced that it has hired Daniel Lanphere, a sales professional with 18 years of direct experience in the technology, data and service solutions industries. Lanphere is a results-driven executive with a diverse background and skillset that encompasses sales, marketing, operations and business resource management in multiple industries. In his role, Lanphere will direct IDI's sales and marketing-related functions, playing a key role in driving the Company's sales strategies to further generate customer demand and achieve revenue objectives.
His professional experience includes senior management positions at Reed Elsevier's LexisNexis, a leading provider in the data fusion industry, among other data and technology-focused companies. His efforts at LexisNexis were a contributing factor behind the company's ability to maintain existing customer relationships within his regions, with the addition of millions of dollars in incremental business. Most recently, he served as Senior Vice President of Sales and Marketing at Verisys Corp., where he was responsible for the growth of the company's SaaS and data aggregation businesses.
Derek Dubner, Co-CEO of IDI, Inc. stated, "We are pleased to have Dan join our expanding team. Given his impressive industry background, we believe he will make a significant contribution to our rapidly growing company. Our ability to attract talent like Dan further validates our strategic plan. We are seeing tremendous enthusiasm for our products and have added hundreds of new customers thus far in 2015. With Dan on-board, we believe customer adoption will only accelerate."
IDI now employs more than 40 people with offices in Boca Raton, Florida; Atlanta, Georgia; and Seattle, Washington.
This press release contains "forward-looking statements," as that term is defined under the Private Securities Litigation Reform Act of 1995 (PSLRA), which statements may be identified by words such as "expects," "plans," "projects," "will," "may," "anticipate," "believes," "should," "intends," "estimates," and other words of similar meaning. Such forward looking statements include statements about whether Daniel Lanphere joining as Vice President of Sales will make a significant contribution to IDI and whether customer adoption of IDI's product will accelerate. There are a number of important factors that could cause actual results or events to differ materially from those indicated by such forward-looking statements, including the risks set forth in IDI's Annual Report on 10-K, filed with the SEC on April 15, 2015, IDI's Quarterly Report on Form 10-Q filed with the SEC on August 14, 2015, as well as the other factors described in the filings that IDI makes with the SEC from time to time. You are cautioned not to place undue reliance on these forward looking statements, which are based on our expectations as of the date of this press release and speak only as of the date of this press release. We undertake no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise.


Pusha T has called time on his beef with Drake saying, as far he is concerned, "it's all over." The DAYTONA rapper spoke to Vanity Fair in an interview published on June 7. When asked if he planned to continue with his "surgical summer," Pusha said: "These conversations have been had and, to my knowledge, it's all over. It's all over with."
Shortly after Pusha T dropped "The Story Of Adidon, both Kanye West and Drake-affiliate J Prince suggested the war of words had come to an end. Speaking about what he has taken from the high-profile clash, Pusha said: "I don't know what was lost or what was gained," before adding that he is "ready to be back to the music for real. Just feeding my base, that's it. That's the most important thing to me at all times."
Read the full Vanity Fair interview here.


We are not currently recruiting at Avoncroft Museum.
Avoncroft will be recruiting a number of other new posts to join our new staff structure over the coming months, so please check back to find out about further vacancies.
If you are interested in volunteering with the Museum, please visit our volunteering page.


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Grime Forum > Music > UK Rap Discussion > Is Dubz ever gonna make a return?
View Full Version : Is Dubz ever gonna make a return?
didnt he quit to go play football?
Dubz is hard, but there are other rapper's in m opinion who are on his level.
didn't he get stabbed up and robbed by some youts in south?
"hear the sound from the heckle and koch, it's goin down when i pepper your spot"
that dubz bar about 031 on 'take it how you want' caused a lot of problems for him. what makes you think youngsta is moist though? cos ill mill/ sms say so?
He got rushed for this tune though. Still went in.
Has he got any other mixtapes/albums beside Ard Doe?
His bars get me gassed everytime!!!!
Dubz is one of the hardis U.K rapper's still, im still waiting for Talk of the town.


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text:
Volume 17 Supplement 5
Selected articles from Statistical Methods for Omics Data Integration and Analysis 2014
DrugQuest - a text mining workflow for drug association discovery
Nikolas Papanikolaou1,
Georgios A. Pavlopoulos1,
Theodosios Theodosiou1,
Ioannis S. Vizirianakis2 &
Ioannis Iliopoulos1
BMC Bioinformatics volume 17, Article number: 182 (2016) Cite this article
Text mining and data integration methods are gaining ground in the field of health sciences due to the exponential growth of bio-medical literature and information stored in biological databases. While such methods mostly try to extract bioentity associations from PubMed, very few of them are dedicated in mining other types of repositories such as chemical databases.
Herein, we apply a text mining approach on the DrugBank database in order to explore drug associations based on the DrugBank "Description", "Indication", "Pharmacodynamics" and "Mechanism of Action" text fields. We apply Name Entity Recognition (NER) techniques on these fields to identify chemicals, proteins, genes, pathways, diseases, and we utilize the TextQuest algorithm to find additional biologically significant words. Using a plethora of similarity and partitional clustering techniques, we group the DrugBank records based on their common terms and investigate possible scenarios why these records are clustered together. Different views such as clustered chemicals based on their textual information, tag clouds consisting of Significant Terms along with the terms that were used for clustering are delivered to the user through a user-friendly web interface.
DrugQuest is a text mining tool for knowledge discovery: it is designed to cluster DrugBank records based on text attributes in order to find new associations between drugs. The service is freely available at http://bioinformatics.med.uoc.gr/drugquest.
The latest advances of next generation sequencing techniques, as well as the rise of the era of personalized medicine, have opened new challenges in the field of Bioinformatics. Data integration, drug discovery, drug repurposing, organization of chemical compound information in databases, identification of their therapeutic properties and their side effects along with the discovery of novel associations between them still remain active research fields.
There is a plethora of widely used databases that attempt to organize chemical information along with others which specialize in drug interactions. Herein, we present a short review of repositories which serve the former purpose. PubChem [1, 2], for example, is a database mainly composed by PubChem Substance, PubChem Compound, and PubChem BioAssay and is designed to provide information on the biological activities of small molecules. Today, PubChem hosts information for about 68,369,263 compounds, 196,730,517 substances, 1,154,333 BioAssays, 2,083,054 tested compounds, 3,141,545 tested Substances, 64 RNAi-BioAssays, 228,500,456 BioActivities, 9853 Protein Targets and 57,039 gene targets. Chemical Entities of Biological Interest (ChEBI) database [3, 4] is a freely available dictionary of molecular entities focused on small chemical compounds. ChemExper (www.chemexper.com) is a web based database which contains information about chemicals and their physical characteristics. ChemExper can be updated manually as everyone is allowed to submit new, update existing and retrieve chemical records online. ChemBank [5] is focused on incorporating small molecules, small-molecule screens and resources towards the gain of biological and medical insights. It is designed to aid chemists in synthesizing novel compounds and biologists in exploring small molecules that perturb specific biological pathways. Side Effect Resource (SIDER) [6] is a great collection of marketed medicines along with their recorded adverse drug reactions and their side effects. At the moment SIDER holds information about 996 drugs, 4192 side effects and 99,423 drug-side effect pairs. ChemSpider (http://www.chemspider.com) is a data integration platform which comes with a fast indexing/searching of over 26 million structures from hundreds of data sources. Its mission is to bring together information from 34 million compounds from over 490 data sources, along with their original source links. Therapeutic Target Database (TTD) [7] provides information about the known and explored therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. This database currently contains 2025 targets (364 successful, 286 clinical trials and 1331 research targets) and 17,816 drugs (1540 approved, 1423 clinical trials, 14,853 experimental drugs and 3681 multi-target agents, 14,170 small molecules and 652 antisense drugs with available structure or oligonucleotide sequence). Targets and drugs in this database cover 61 protein biochemical classes and 140 drug therapeutic classes respectively. SuperTarget/Matador [8] is designed to give answers to complex queries such as finding drugs that are metabolized by the same enzyme, drugs that target a certain metabolic pathway or even drugs that target the same protein but are metabolized by different enzymes. The scenarios are based on information about medical indication areas, adverse side effects and drug metabolism. Currently, the database contains more than 2500 target proteins, which are annotated with about 7300 relations to 1500 drugs. Finally, SuperDrug [9] contains approximately 2500 chemical structures of active ingredients of essential marketed drugs. At the moment, it contains 2.396 compounds with 108.198 conformers.
In this article, we focus on the DrugBank [10–12] repository which is a freely available resource that combines detailed information about 7736 drug entries including 1584 FDA-approved small molecule drugs, 158 FDA-approved biotech (protein/peptide) drugs, 89 nutraceuticals and over 6000 experimental drugs. For each drug, information about taxonomy, pharmacology, pharmacoeconomics, chemical properties, related literature and other chemical interactors can be retrieved along with information about its targeted proteins.
DrugQuest clusters DrugBank records based on their textual information in a multidimensional vector space. We mainly apply partitional clustering algorithms in order to group together DrugBank records based on their textual information. Toxicity, targeted pathways, targeted proteins, diseases and/or other interactors are few examples of such textual information. Uniquely assigning DrugBank records into clusters, based on tagged terms such as pathways diseases, molecules, biological processes, can make DrugQuest a promising tool for new concept discovery and detection of new drug associations. The platform is available at http://bioinformatics.med.uoc.gr/drugquest.
An overview of DrugQuest's workflow in steps
The workflow of DrugQuest is summarized below in ten steps and presented analytically in Fig. 1.
DrugQuest's workflow. a Queries to DrugBank and retrieval of records related to the query. b DrugBank record mining based on textual information such as: description, toxicology and pharmacology. c Name Entity Recognition techniques to identify genes/proteins, chemicals, diseases, pathways. d TextQuest algorithm to identify non tagged Significant Terms. e Partitional clustering of DrugBank records using various clustering algorithms and similarity measures. f Visual representation of results: Left: Tag cloud example of highly representative terms per cluster. Right: DrugBank records assigned to clusters
The user provides a query (keyword matching using Boolean operators).
Selection of relevant DrugBank records upon query based on the "Description", "Indication", "Pharmacodynamics" and "Mechanism of Action" fields of the DrugBank records.
Retrieval of textual entries of the drug records from the local database, where DrugBank is stored.
Collection of tagged terms for each record. Notably, the tagging of the whole DrugBank repository has been performed beforehand, in order to avoid unnecessary bottlenecks for the user. DrugQuest uses the Reflect tagging service [13] to identify proteins and chemicals and the BeCAS tagging service for diseases/disorders and pathways identification.
Calculation of the TF-IDF score (Term Frequency x Inverse Document Frequency) for each of non-tagged words in the textual corpus to determine its 'importance'.
Removal of English words with low TF-IDF values based on the British National Corpus (BNC - http://www.natcorp.ox.ac.uk/), a collection of samples of written and spoken language from a wide range of sources, accompanied by the respective word frequencies, designed to represent a wide cross-section of British English, both spoken and written, from the late twentieth century.
Removal of words belonging to a custom designed "stop word list" with common English words, such as articles and prepositions. The remaining words, after steps (4) - (7) will be characteristic for each abstract and will be referred as "Significant Terms".
Creation of binary vectors representing each DrugBank record, indicating the presence or absence of Significant Terms and of tagged terms representing proteins, chemicals, diseases and pathways. In these vectors, the TF-IDF value is not taken into account.
Document clustering is performed with a user-defined combination of metric-clustering algorithm (selected among different available options).
Annotated representations and visualization of the results in two forms i.e. "Tag Clouds" and "Clustered Drugs" allow user to detect which of the terms belong to the four tagging categories.
Query system
DrugQuest is a freely available, easy-to use web application which mines the DrugBank repository and clusters its records based on their textual information towards the discovery of new drug associations. It comes with a user friendly Google-like interface where one can query for a symptom (i.e. "pain", "headache" etc.) and retrieve the relevant to the query DrugBank records. Notably, DrugQuest's query system at the moment allows for simple keyword string matching within the textual information of each DrugBank record. Users can choose between simple Boolean operators ('OR' for any query term and 'AND' for all query terms). As each DrugBank record consists of various fields, we selected for fields with a high textual information content, more particularly: "Description", "Indication", "Pharmacodynamics" and "Mechanism of Action".
Automated identification of terms
Named Entity Recognition techniques have been applied on the locally stored and parsed DrugBank (version 4.2) repository. To minimize the gene/protein and chemical disambiguation problem and cope with the complexity of multiple synonyms, we link synonymous terms to unique database identifiers by utilizing the Reflect tagging service [13]. Similarly, for diseases and pathways we utilized the BeCAS tagging service [14]. This way, gene and protein names are mapped to ENSEMBL identifiers, drug/chemical names to PubChem [1, 2], diseases/disorders to a subset of UMLS [15] and pathways to the NCBI BioSystems repository [16]. Prior to using the tagged terms identified by both tagger, we manually checked for redundancies and inconsistencies.
In order to take advantage of the remaining untagged text, we utilize the TextQuest algorithm [17] to identify biologically significant words. Such words may refer to a phenomenon or a biological process or a function and might be worthy of attention. Shortly, the TextQuest algorithm initially calculates the TF-IDF score (Term Frequency x Inverse Document Frequency) for each word in the corpus to determine its 'significance'. Then it removes the words with low TF-IDF scores and words belonging to a custom designed "stop word list" with common English words, such as articles and prepositions. The remaining words are characteristic for each abstract and we treat them as 'Significant Terms'.
Ideally, a tagger should identify all synonyms and redirect them to the same database record. In the very rare cases where this does not occur, two synonyms may both appear as Significant Terms.
Document clustering
Prior to partitional clustering, we represent each DrugBank record with a binary vector holding the presences and the absences of the tagged and the other/remaining biologically significant terms (not captured by the taggers) that were found in the text collection. Similarity metrics such as Tanimoto coefficient, Pearson coefficient or simple cosine similarity are then calculated in order to construct an all-against-all similarity matrix between the retrieved DrugBank records, relevant to a query. Based on this similarity matrix, we subsequently apply a partitional algorithm (among several algorithms that are available) to group the retrieved records and assign them to distinct clusters based on their textual information. At the moment, a plethora of clustering algorithms such as Affinity Propagation [18], MCL [19], k-Means [20], average linkage hierarchical clustering from SCPS [21] and spectral [22] clustering algorithms can be used.
Representation of results and on-the-fly data integration
DrugQuest delivers different views of the results organized under tabs, along with a frame holding a summary of the analysis. The "Tag Clouds" view displays a tag-cloud of the Significant Terms that characterize each document cluster. The font size of each text is proportional to the frequency of the term in the respective cluster and, therefore, the bigger the size, the more over-represented the term. More specifically, the font size of each Significant Term is proportional to the number of records of each cluster in which the term appears. Terms that do not appear very often (based on an empirically chosen TF-IDF threshold of 19) in each cluster are not shown in order to present a less 'cluttered' and more user-friendly cluster. In this view, users can highlight terms that are unique for a cluster as well as tagged genes/proteins, chemicals, pathways, diseases and terms that are not standard English terms (i.e. they do not belong in the reference English dictionary). The "Clustered Drugs" tab categorizes the DrugBank records in subjects corresponding to implicit concepts accompanied with a link to the respective DrugBank record.
Implementation and running time
DrugBank repository is stored locally in a MySQL database. The web interface is written with the use of CGI, Perl and Javascript. The MCL algorithm is written in C while the rest of the clustering algorithms in Java taken from the jClust java application [23]. Finally, vector similarities are calculated with the use of R package [24]. As DrugQuest has a limit of 5000 textual records per analysis, the running time complexity of the algorithms is not an issue. Moreover, due DrugBank's small size, each query normally lasts few seconds to process.
Pharmacological exploitation of DrugQuest usefulness through the example of the term 'aspirin'
Aspirin (acetylsalicylic acid) is one of the most widely used drugs, since it has been in the market for more than 100 years (first synthesis and clinical trial in 1897–1899). Aspirin belongs to the pharmacological class of non-steroidal anti-inflammatory drugs (NSAIDs). The pharmacological mechanism of action of aspirin is mediated through the inhibition of both cyclooxygenases 1 and 2 (COX-1, COX-2), thus decreasing pain, fever, and inflammation. Interestingly, besides its well-known analgesic, antipyretic and anti-inflammatory activity, aspirin also exerts anticoagulant effects by inhibiting platelet aggregation. The favorable response of aspirin in reducing fever is mediated through the inhibition of prostaglandin E2 (PGE2) synthesis. A more recently developed class of NSAIDs is that of COX-2 specific inhibitors, such as celecoxib [25–28].
In the following example, by querying for "aspirin" in DrugQuest and using the MCL clustering algorithm with inflation value 3, the pharmacological usefulness of this text-mining biomedical suite is clearly displayed. The MCL algorithm calculates automatically the number of clusters, i.e. the user does not provide a preference bias for the number of clusters. As shown in Fig. 2, four clusters have been recovered. The analysis of tags grouped in each cluster revealed that: a) Cluster 1 consists of i) tags focusing on the anticoagulant blood effects of aspirin in related diseases including other anticoagulant drug classes (tags: platelets, antiplatelet, thromboxane, glycoprotein, GPIIb/IIIa, IIb/IIIa, fibrinogen, endothelial, vascular disease, ischemic) and ii) analgesic, antipyretic and anti-inflammatory activities of aspirin as well as the related diseases and other classes of relevant drugs (tags: prostaglandin, anti-inflammatory, Cox-1, COX-2, non-steroidal, NSAIDs, NSAID, analgesic, antipyretic, rheumatoid arthritis, arachidonic acid, cyclooxygenase(s), cyclooxygenase, juvenile rheumatoid arthritis, osteoarthritis); b) Cluster 2 tags refer to combination therapy of aspirin with other pharmacological classes of drugs (tags: barbiturate(s), caffeine, CNS, GABA, GABA A , headaches, migraines, mood alteration, sedative, depressants, thalamus). For example, as shown in DrugBank, "Butalbital is often combined with other medications, such as acetaminophen or aspirin, and is commonly prescribed for the treatment of pain and headache…Methylphenobarbital … and thiamylal are barbiturates …. often combined with aspirin"; c) Cluster 3 tags propose combination therapy of aspirin with other analgesic drugs for the relief of pain in severe conditions (tags: oxycodone, coma, codeine, hydrocodone, addicting, opiods, narcotic, pain, severe pain, CNS, 3-methoxy-17-methylmorphinan). For example, as shown in DrugBank, "Oxycodone… and hydrocodone are narcotic analgesics … often combined with aspirin". d) Cluster 4 tags point to a specific disease where aspirin is included in the therapeutic protocol, e.g. heart diseases (tags: angina pectoris, anticoagulant, antithrombin, anti-Xa, clotting, embolisms, heparins, induced thrombocytopenia, ischemic, LMWH, low molecular weight heparin, myocardial infractions, prothrombin, thrombin, thrombosis, thromboplastin, unstable angina pectoris, venous thrombosis).
Aspirin Example. Tag Cloud view for term "aspirin" related query. Cluster 1: tags focusing on the anticoagulant blood effects of aspirin in related diseases including other anticoagulant drug classes along with analgesic, antipyretic and anti-inflammatory activities of aspirin. Cluster 2: tags refer to combination therapy of aspirin with other pharmacological classes of drugs. Cluster 3: tags propose combination therapy of aspirin with other analgesic drugs for the relief of pain in severe conditions. Cluster 4: tags point to a specific disease where aspirin is included in the therapeutic protocol, e.g. heart diseases
Overall, the classification of knowledge related to 'aspirin' by DrugQuest in these 4 clusters corresponds to the various levels of the existing pharmacological information for this old drug. Importantly, this information is appropriately categorized providing an overview of the drug in a way that could be useful for both research and educational purposes to healthcare practitioners, healthcare policy makers, regulatory agencies and pharmacologists.
Detecting drugs belonging to the pharmacological class of selective serotonin-reuptake inhibitors (SSRIs)
Antidepressant drugs belonging to the class of selective serotonin-reuptake inhibitors (SSRIs) are used as an additional case study to further exemplify the usefulness of DrugQuest. In particular, very similar SSRI drugs such as citalopram, fluoxetine, paroxetine and sertraline were compared to each other in order to pinpoint differences and similarities. According to DrugBank, despite SSRIs act as potent inhibitors of neuronal serotonin re-uptake, they do not substantially affect norepinephrine or dopamine reuptake nor do they antagonize α- or β- adrenergic, dopamine D2 or histamine H1 receptors. In this manner, SSRIs affect somatodendritic 5-HT1A and terminal autoreceptors that subsequently lead to adaptive changes in neuronal function, thus leading to enhanced serotonergic neurotransmission. Moreover, the clinical use of SSRIs can lead to the emergence of adverse drug reactions (ADRs), like dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache [29–32].
As shown in Fig. 3, by querying for each of the aforementioned drugs and using the MCL algorithm, DrugQuest produced one cluster with Significant Terms for each of them. By inspecting the tag content of the relevant clusters we clearly observe two traits: i) common tags characterizing the class of SSRIs (in terms of pharmacological effects, ADRs, and/or clinical uses) appear in all four clusters (5-HT, CYP, adrenergic, antidepressant, autoreceptors, CNS, desensitization, dopamine, drowsiness, D 2 , headaches, histamine, H 1 , irritable bowel, nausea, OCD, panic disorder, MDD, premature ejaculation, premenstrual dysphoric disorder, PTSD, reuptake, serotonergic, serotonin, sexual dysfunction, somatodendritic, SSRIs, tremors, vertigo, watery stools, xerostomia). ii) tags related to specific pharmacological, chemical or clinical properties of each individual drug appearing in each respective cluster. The Citalopram cluster is uniquely characterized by the terms DCT, antibulimic, benzodiazepine, dysmorphic disorder, coma, convulsions, GABA, monoamine, mood disorders, oxidase, sinus tachycardia. Similarly, the Fluoxetine cluster is uniquely characterized by the terms 1,2,4-triazole, Benzene, bulimia nervosa, chlorobenzene, diazinane, flu-like symptoms, influenza, loss of appetite, low libido, skin rashes. In the Paroxetine cluster, the terms Arthritis, rheumatoid arthritis are over-represented whereas in the Sertraline cluster, the terms flushing, hot flush are highlighted.
SSRIs Example. Tag Cloud view for drugs "citalopram", "fluoxetine", "paroxetine" and "sertraline". Orange: common tags characterizing the class of SSRIs (in terms of pharmacological effects, ADRs, and/or clinical uses). Blue: tags related to specific pharmacological, chemical or clinical properties of each individual drug appearing in each respective cluster
DrugQuest is a concept discovery tool mainly designed for finding new associations between known drugs but also for providing concise summation of a large corpus of drug-related knowledge. It uses textual information related to a drug and allows clustering algorithms to group chemicals based on this information. As it is chemically oriented, it differs significantly from its sister project BioTextQuest [33, 34], which is mainly developed to mine PubMed and cluster PubMed documents into topics. Among others, one of the main differences is that DrugQuest additionally uses tagging services at the back-end to cope with the complexity of multiple synonyms and chemical disambiguation, a feature that is missing in the BioTextQuest application.
To our experience and from a text mining point of view, chemical databases are peculiar in terms of the terminology and the vocabulary used, and small name changes may refer to completely different molecules with different properties and characteristics. Therefore, pre-defined tagging services were necessary to spot such details as opposed to BioTextQuest that mines textual corpuses more freely.
Despite the fact that the gene/protein annotation provided by the Reflect API and the Reflect Web Service [13] can vary, probably due to the backend dictionary updates, we insisted in using the API to pre-annotate the whole DrugBank. This allowed us to avoid invoking the external Reflect Web Service on the fly, sidestepping any Reflect Web Service downtime and time bottlenecks.
DrugQuest currently mines the DrugBank repository, but we aim to integrate other repositories like the ones mentioned in the introductory section (PubChem, ChEBI, SuperTarget/Matador etc.). Notably, we chose to start with the DrugBank database because of its smaller size, a fact that renders it easier for parsing. It is well maintained and many records are manually curated while it is frequently referenced by other resources.
Overall, we believe that the philosophy of DrugQuest could be a promising approach and a good starting point in mining chemical-related repositories and can boost the extraction of new knowledge by bringing unobserved drug repurposing and drug repositioning scenarios on the surface.
DrugQuest is a web application that utilizes state-of-the-art text mining methodologies, name entity recognition techniques and data-integration approaches to mine the DrugBank repository and group chemicals/drugs based on their textual information.
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The publication costs for this article were funded by the European Commission FP7 programs INFLA-CARE (EC grant agreement number 223151), 'Translational Potential' (EC grant agreement number 285948). We thank Dr. Evangelos Pafilis for helping us with the tagging services and the web interface.
This article has been published as part of BMC Bioinformatics Volume 17 Supplement 5, 2016: Selected articles from Statistical Methods for Omics Data Integration and Analysis 2014. The full contents of the supplement are available online at http://bmcbioinformatics.biomedcentral.com/articles/supplements/volume-17-supplement-5.
Division of Basic Sciences, University of Crete, Medical School, Gouves, 71003, Heraklion, Crete, Greece
Nikolas Papanikolaou, Georgios A. Pavlopoulos, Theodosios Theodosiou & Ioannis Iliopoulos
School of Pharmacy, Laboratory of Pharmacology, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece
Ioannis S. Vizirianakis
Nikolas Papanikolaou
Georgios A. Pavlopoulos
Theodosios Theodosiou
Ioannis Iliopoulos
Correspondence to Ioannis Iliopoulos.
NP was the main developer of the interface and the pipeline analysis behind DrugQuest. GAP was behind the tagging services and the clustering analysis and TT behind the statistics and the mathematics involved. ISV provided us with the test cases. NP, GAP and II conceived the idea, participated in its design and drafted the manuscript. II was the main supervisor of the project. All authors have read and approved the manuscript.
Papanikolaou, N., Pavlopoulos, G.A., Theodosiou, T. et al. DrugQuest - a text mining workflow for drug association discovery. BMC Bioinformatics 17, 182 (2016). https://doi.org/10.1186/s12859-016-1041-6
Drug associations
Name entity recognition
Submission enquiries: bmcbioinformatics@biomedcentral.com


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Home / Business / New Instagram Tools For Brand Management
New Instagram Tools For Brand Management
Over the last few years, Instagram has become the go-to social network for online branding and digital marketing. Since its billionaire acquisition by Facebook, Instagram has undergone a gradual transformation from image sharing platform to a powerful tool for brands to interact with customers and prospects, and this has a lot to do with the vision of the business and development teams at the social network.
In November 2020, just before the start of the holiday shopping season in the midst of the coronavirus pandemic, Instagram rolled out two new features that should be of special interest to brand managers, influencers, and content creators. Let's take a closer look at these features:
Branded Content Advertisers Get More Freedom
In June 2019, Instagram rolled out a feature that allows advertisers to work closer with content creators. Branded Content Ads serve a couple of purposes; first of all, they let Instagram users know that certain stories appearing in their feeds are paid advertisements. Second, these branded stories highlight the collaboration between influencers and the advertisers, thus allowing users to interact directly with the content creators as well as the brands should they choose to do so.
The new feature augmenting Branded Content Ads gives brand managers more creative control. Let's say a fashion boutique has an existing partnership with a busy influencer but does not want to wait for her to create new Instagram Stories. The boutique can now produce the ad and pitch it to the influencer for instant approval. Although this feature intends to streamline existing processes, it could also create friction if approvals are not obtained right away.
New Branded Hashtags
Take a look at this example of Instagram profile hashtag use; notice how the relevant tags in each post are assigned naturally. Starting in November 2020, a new kind of hashtag will be available to Instagram content creators and the brands they work with. Branded content tags for paid advertising will be part of Instagram Live as well as Reels, two features that have proven to be very popular on the network, and which are designed to compete against the likes of Facebook Live, Snapchat, and Tik-Tok. Although these tags will be visible to users, they will not have an impact on the viewing experience. The purpose of branded tags can be appreciated in the background by the publishers and advertisers; similar to Facebook pixels, they provide advanced analytics on the performance of Instagram campaigns, and marketers will be able to develop strategies based on these actionable insights.
Thus far, Instagram influencers and their commercial partners have reacted positively to the new features, particularly the new ability given to brands to interact directly with users. Let's say a professional soccer player works with an online casino on a series of Instagram Stories, but she is not able to respond to questions from followers because she needs to focus on the current season. With the new Branded Content Ads feature, advertisers will be able to respond directly to such questions without having to consult with the player or get access to her account.
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Secluded, private and serene 38+ acres located at approximately SW 84th and Van Dorn, just south of the village of Emerald. There is also an additional 80 acres available attached to this tract if the buyer wishes to add more land to the existing 38 available. For a total of 118 available acres. This property is set way back away from the road, with an owned driveway from the South (Van Dorn) and an easement from the East (SW 84th). This fantastic acreage location has meadow, trees, and wildlife with a small pond and seasonal creek. There are several excellent locations on this property for your dream home. Choose to build with amazing views of the Capital to the east and spectacular sunrises to the west, or choose a spot completely hidden in the trees, or with the pond off your back deck. You will feel as though you are far out into the countryside, yet only a few minutes to downtown Lincoln. The Seller has done much to prepare this property for new owners, including assuring that the East driveway is a recorded easement. Extensive dirtwork has been done to ensure proper drainage, with all runoff directed to the pond and seasonal creek. If you prefer to wait to build, this property has the ability to provide some extra income through leasing the crop land or pasture. The crop land is currently planted to winter wheat.
There are few places where you can be completely secluded in a gorgeous rural setting, and yet be 10 minutes from the Haymarket, PBA, and Memorial Stadium! Don't let this opportunity get away!


All things considered having a baby can be stressful and a good percentage of new mothers are anxious and feel overwhelmed immediately after birth. While baby blues are normal anxiety and other unpleasant symptoms become a source of concern when they do not resolve themselves after two weeks or so after bringing the new bundle of joy home. This now becomes postpartum depression that may come with mild to severe symptoms that may last up to one year after delivery. Below we discuss all reasons and symptoms of postpartum depression and also give tips and tricks on how this condition can be dealt with or avoided altogether.
Going by the above symptoms it would be safe to say that postpartum depression involves a wide range of symptoms and emotions that may eventually interfere with the mother ability to take care of the new baby and also take care of herself.
Most women with postpartum depression do not experience the above symptoms all at once. Initially this will feel more like baby blues but the symptoms will persist and become severe over time. For some women mild symptoms start immediately after birth and get more serious with time. For other women symptoms may appear several months after giving birth.
Every woman experiences drastic hormonal changes after birth. Progesterone, estrogen and thyroid levels fall drastically and this drastic fall in hormones has different effects in the body such that may trigger postpartum depression.
Taking care of a new baby can be depressing especially if a new mother does not have a proper support system at home. For mothers who have not had previous experience in taking care of a new born feelings of inadequacy and anxiety may lead to stress which may trigger postpartum depression. Babies also come with sleepless nights and this means that a new mother may be sleep deprived, tired and often stressed. Other stress triggers such as having a sick child, losing your job and pregnancy complications can also trigger this condition.
Pregnancy and birth come with numerous physical changes such as rapid weight gain. A woman who may be having a hard time shedding this weight after delivery may suffer from postpartum depression. It does not help that for some women having postpartum depression makes them eat excessively and this may make the condition even worse. This and Physical pain that most women experience after birth may also trigger this postpartum depression.
The above factors just act as triggers since some women who encounter all the above factors do not suffers from the above condition while others do. Generally the exact reason why this happens to some women while others escape is not known. However, the following situations have been known to increase the likelihood of a mother developing postpartum depression.
While this condition comes with many unpleasant effects on the mother and also affects the baby negatively, the good news is that it is manageable and does not have to get severe and affect the baby and mother for an extended period of time.
For women with postpartum depression the first step to healing is accepting that they have the condition. The next course of action after acceptance should be seeking help from a doctor and others who have gone down this road before.
If you suspect that you may be suffering from this condition here are some tips that may help you cope even as you seek professional help.
Get help from friends and relatives when it comes to running your daily errands and taking care of the baby. Use those short breaks in between taking care of the baby to get some rest and sleep especially if your baby is keeping you awake for a good portion of the night.
Track your thoughts and emotions daily and do everything possible to only think happy thoughts and keep your emotion on check.
Remember that a new baby is stressful to everyone, even those who have had babies before. You should therefore not feel inadequate for feeling overwhelmed and not excited by the arrival of the newest family member.
Reach out to friends and relatives and let them help you get through those difficult days. Talk to them and cry if you have to as long as you will feel much better afterwards.
Postpartum depression is a condition that affects many new mom and if you look at all reasons and symptoms of postpartum depression it will become apparent that there is nothing to be ashamed of. If you notice any of the symptoms mentioned above seek professional help and talk about your feelings to those who care about you. Above all take things easy and take comfort in that this too will come to pass and you can look forward to many happy days with your baby and the rest of the family. For those with loved ones who are suffering from this condition the best you can offer is support and encourage your loved ones to seek medical attention immediately instead of waiting and hoping that the symptoms will go away over time.


Training sessions are happening all over our Greater Houston area and supporting towns. We also like to see what positive things have been happening on the streets. Let's show the world how us Peacekeepers keep the peace (and traffic) moving.


He showed his ________ by continuing despite an injury.
Picture a cool night, cuddling with the one you love, and gazing at the stars. Doesnt that sound like a great way to spend your Valentines? Absolutely. Thats what you will get with this romantic date.


Tiffani Faison, Casey Thompson, more prepping premium holiday menus.
This Christmas, you can literally bring Top Chef to your table -- but it'll cost you. FOX411.com tracked down some of our Top Chef All-Stars, and found them prepping private meals for foodie fanatics willing to dish out a little bit of dough.
Tiffani Faison of Season 1 explains what she'll be doing for her menus, which start at $500: "I'll find beautiful cheeses that I know a particular guest will like, play with some adventurous spices and pair food with wines I know my guests will love." We hope she's including those drool-worthy Rice Crispy Treat Snowball with Malted Milk and Graham Crackers.
Meanwhile, Season 4's Dale Talde is serving up a $500 comfort-food masterpiece menu, including "dry aged prime rib, popovers, whole roasted duck, foie gras terrine, raw bars with fresh popped oysters, Maine lobsters, uni, and fresh Dungeness crab dinner." No mention if his breakfast veal-loin will be provided for more adventurous eaters.
Other All-Stars are offering private dining experiences as well, including Casey Thompson and Tiffany Derry -- to see what they're whipping up (and what it will cost you), check out FOX411.


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