text:
Taylor:Publications
303. Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2020). Interplay of Adsorption, Supersaturation and the Presence of an Absorptive Sink on Drug Release from Mesoporous Silica-Based Formulations. Pharmaceutical Research. 37(8):163 1-18. http://dx.doi.org/10.1007/s11095-020-02879-9
302. Ueda, K., and Taylor, L. S. (2020). Impact of hypromellose acetate succinate grade on drug amorphous solubility and in vitro membrane transport. Journal of Pharmaceutical Sciences. 109(8): 2464-2473. http://dx.doi.org/10.1016/j.xphs.2020.04.014
301. McCarthy, C. A., Zemlyanov, D., Crean, A. M., Taylor, L. S. (2020). Comparison of Drug Release and Adsorption Under Supersaturating Conditions for Ordered Mesoporous Silica with Indomethacin or Indomethacin Methyl Ester. Molecular Pharmaceutics. 17(8): 3062–3074. http://dx.doi.org/10.1021/acs.molpharmaceut.0c00489
300. Enright, E. F., Joyce, S. A., Gahan, C. G. M., Taylor, L. S. (2020) Impact of phospholipid digests and bile acid pool variations on the crystallization of atazanavir from supersaturated solutions. European Journal of Pharmaceutics and Biopharmaceutics. 153: 68-83. http://dx.doi.org/10.1016/j.ejpb.2020.05.022
299. Parker, A. S., Taylor, L. S., and Beaudoin, S. P. (2020). The Role of Surface Energy Heterogeneity on Crystal Morphology during Solid-State Crystallization at the Amorphous Atazanavir-Water Interface. CrysEngComm. 22, 3179-3187. http://dx.doi.org/10.1039/C9CE02007A
298. Trasi, N. S., Bhujbal, S.V., Zhou, Q. T., and Taylor, L. S. (2020). Physical Stability and Release Properties of Lumefantrine Amorphous Solid Dispersion Granules Prepared by a Simple Solvent Evaporation Approach. International Journal of Pharmaceutical Sciences X, 100052. http://dx.doi.org/10.1016/j.ijpx.2020.100052
297. Que, C., Qi, Q., Zemlyanov, D. Y., Mo, H., Deac, A., Zeller, M., Indulkar, A. S., Gao, Y,. Zhang, G. G. Z., and Taylor, L. S. (2020). Evidence for Halogen Bonding in Amorphous Solid Dispersions. Crystal Growth and Design. 20 (5): 3224–3235. http://dx.doi.org/10.1021/acs.cgd.0c00073
296. Saboo, S. S., Kestur, U. S., Flaherty, D. P., Taylor, L. S. (2020) Congruent release of drug and polymer from amorphous solid dispersions: insights into the role of drug-polymer hydrogen bonding, surface crystallization and glass transition. Molecular Pharmaceutics. 17(4): 1261–1275. http://dx.doi.org/10.1021/acs.molpharmaceut.9b01272
295. Ueda, K., and Taylor, L. S. (2020). Polymer type impacts amorphous solubility and drug-rich phase colloidal stability: A mechanistic study using nuclear magnetic resonance spectroscopy. Molecular Pharmaceutics. 17(4):1352-1362 http://dx.doi.org/10.1021/acs.molpharmaceut.0c00061
294. Moseson, D.E., Parker, A.S., Beaudoin, S.P., and Taylor, L.S., (2020) Amorphous Solid Dispersions Containing Residual Crystallinity: Influence of Seed Properties and Polymer Adsorption on Dissolution Performance. European Journal of Pharmaceutical Sciences. 146: 105276. http://dx.doi.org/10.1016/j.ejps.2020.105276
293. Wilson, N.E., Mutukuri, T.T., Zemlyanov, D.Y., Taylor, L. S., Topp, E.M., Zhou, Q. T. (2020). Surface Composition and Formulation Heterogeneity of Protein Solids Produced by Spray Drying. Pharmaceutical Research. 37(1):14. http://dx.doi.org/10.1007/s11095-019-2738-9
292. Sherman, A. M., Geiger, A. C., Smith, C.,Taylor, L. S. Hinds, J., Stroud, P., Simpson, G. J. (2020). Stochastic Differential Scanning Calorimetry by Nonlinear Optical Microscopy. Analytical Chemistry. 92(1): 1171-1178. http://dx.doi.org/10.1021/acs.analchem.9b04300
291. Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2020). Absorptive dissolution testing: An improved approach to study the impact of residual crystallinity on the performance of amorphous formulations. Journal of Pharmaceutical Sciences. 109(3): 1312-1323. http://dx.doi.org/10.1016/j.xphs.2019.11.016.
290. Indulkar, A. S., Raina, S. A., Gao, Y., Zhang, G. G. Z., and Taylor, L. S. (2020). Impact of monomeric vs. micellar surfactant and surfactant-polymer interactions on nucleation-induction times of atazanavir from supersaturated solutions. Crystal Growth and Design. 20(1):62-72. http://dx.doi.org/10.1021/acs.cgd.9b00482
289. Trasi, N. S., Bhujbal, S.V., Zhou, Q. T., and Taylor, L. S. (2019). Amorphous Solid Dispersion Formation via Solvent Granulation – A Case Study with Ritonavir and Lopinavir. International Journal of Pharmaceutics. X 1, 100035. http://dx.doi.org/10.1016/j.ijpx.2019.100035
288. Que, C., Lou, X., Zemlyanov, D. Y., Mo, H., Indulkar, A. S., Gao, Y., Zhang, G. G. Z. and Taylor, L. S. (2019). Insights into the Dissolution Behavior of Ledipasvir-Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions. Molecular Pharmaceutics. 16(12):5054-5067. http://dx.doi.org/10.1021/acs.molpharmaceut.9b01025
287. Elkhabaz, A., Sarkar, S., Simpson, G. J., and Taylor, L.S. (2019). Characterization of Phase Transformations for Amorphous Solid Dispersions of a Weakly Basic Drug upon Dissolution in Biorelevant Media. Pharmaceutical Research. 36 (12), 174. http://dx.doi.org/10.1007/s11095-019-2718-0
286. Tres, F., Posada, M. M., Hall, S. D., Mohutsky, M. A., and Taylor, L. S. (2019). The Effect of Promiscuous Aggregation on In Vitro Drug Metabolism Assays. Pharmaceutical Research. 36 (12), 170. http://dx.doi.org/10.1007/s11095-019-2713-5
285. Elkhabaz, A., Moseson, D. E., Brouwers, J., Augustijns, P., and Taylor, L.S. (2019). Interplay of supersaturation and solubilization: Lack of correlation between concentration-based supersaturation measurements and membrane transport rates in simulated and aspirated human fluids. Molecular Pharmaceutics. 16 (12):5042-5053. https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00956
284. Voelker, A.L., Verbeek, G., Taylor, L. S. and Mauer, L. J. (2019). Effects of emulsifiers on the moisture sorption and crystallization of amorphous sucrose lyophiles. Food Chemistry. 3:100050. http://dx.doi.org/10.1016/j.fochx.2019.100050
283. Purohit, H.S., Trasi, N.S., Osterling, D.J., Stolarik, D.F., Jenkins, G.J., Gao, W., Zhang, G.G.Z., Taylor, L.S. (2019). Assessing the Impact of Endogenously Derived Crystalline Drug on the in Vivo Performance of Amorphous Formulations. Molecular Pharmaceutics. http://dx.doi.org/10.1021/acs.molpharmaceut.9b00455
282. Dening, T.J., Zemlyanov, D., Taylor, L.S. (2019). Application of an adsorption isotherm to explain incomplete drug release from ordered mesoporous silica materials under supersaturating conditions. Journal of Controlled Release. 307:186-199. http://dx.doi.org/10.1016/j.jconrel.2019.06.028
281. Dong, Y., Novo, D.C., Mosquera-Giraldo, L.I., Taylor, L.S., and Edgar, K. J. (2019). Cellulose-Bile Ester Conjugates by Olefin Cross-metathesis: A CM Strategy for Access to Complex Polysaccharide Structures. Carbohydrate Polymers 221: 37-47. http://dx.doi.org/10.1016/j.carbpol.2019.05.061
280. Moseson, D. E., Parker, A. S., Gilpin, C. J., Stewart, A. A., Beaudoin, S. P. and Taylor, L. S. (2019). Dissolution of Indomethacin Crystals into a Polymer Melt: Role of Diffusion and Fragmentation. Crystal Growth and Design.19:3315-3328. http://dx.doi.org/10.1021/acs.cgd.9b00200
279. Li, N., and Taylor, L.S. (2019). Microstructure Formation for Improved Dissolution Performance of Lopinavir Amorphous Solid Dispersions. Molecular Pharmaceutics. http://dx.doi.org/10.1021/acs.molpharmaceut.9b00117
278. Saboo, S., Mugheirbi, N. A., Zemlyanov, D.Y., Kestur, U. S., and Taylor, L. S. (2019) Congruent release of drug and polymer: A "sweet spot" in the dissolution of amorphous solid dispersions. Journal of Controlled Release. 298:68-82. http://dx.doi.org/10.1016/j.jconrel.2019.01.039
277. Indulkar, A. S., Lou, X., Zhang, G. G. Z., and Taylor, L. S. (2019). Insights into the dissolution mechanism of ritonavir-copovidone amorphous solid dispersions: importance of congruent release for enhanced performance. Molecular Pharmaceutics. 16(3):1327-1339.http://dx.doi.org/10.1021/acs.molpharmaceut.8b01261
276. Mauer, L. J., Forny, L., Meunier, V., and Taylor, L. S. (2019). Optimizing the quality of dry ingredient blends and powder products: the challenges of moisture-mediated phase transformations. Annual Review of Food Science and Technology. 10:457-478. http://dx.doi.org/10.1146/annurev-food-032818-121224
275. Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2019). Insight into Amorphous Solid Dispersion Performance by Coupled Dissolution and Membrane Mass Transfer Measurements. Molecular Pharmaceutics. 16(1):448-461. http://dx.doi.org/10.1021/acs.molpharmaceut.8b01117
274. Wilson, V. Lou, X., Osterling, D. J., Stolarik, D. F., Jenkins, G., Gao, W., Zhang, G. G. Z., and Taylor, L. S. (2018). Relationship between amorphous solid dispersion in vivo absorption and in vitro dissolution: phase behavior during dissolution, speciation, and membrane mass transport. Journal of Controlled Release. 292:172-182.. http://dx.doi.org/10.1016/j.jconrel.2018.11.003
273. Hsu, H., Taylor, L. S., and Harris, M. T. (2018). Impact of Additives on Heterogeneous Crystallization of Acetaminophen. International Journal of Chemical Engineering. http://dx.doi.org/10.1155/2018/3604320
272. Mosquera-Giraldo, L. I., Borca, C. H., Parker, A. S., Dong, Y., Edgar, K. J., Beaudoin, S. P., Slipchenko, L.V, and Taylor, L. S. (2018). Crystallization Inhibition Properties of Cellulose Esters and Ethers for a Group of Chemically Diverse Drugs - Experimental and Computational Insight. Biomacromolecules. 19(12):4593-4606 http://dx.doi.org/10.1021/acs.biomac.8b01280
271. Moseson, D. E., Mugheirbi, N. A., Stewart, A. A., and Taylor, L. S. (2018) Nanometer-Scale Residual Crystals in a Hot Melt Extruded Amorphous Solid Dispersion: Characterization by Transmission Electron Microscopy. Crystal Growth and Design. 18(12):7633-7640. http://dx.doi.org/10.1021/acs.cgd.8b01435
270. Moseson, D. E. and Taylor, L. S. (2018). The application of temperature-composition phase diagrams for hot melt extrusion processing of amorphous solid dispersions to prevent residual crystallinity. International Journal of Pharmaceutics. 553(1-2):454-466. http://dx.doi.org/10.1016/j.ijpharm.2018.10.055
269. Patel, M. A., Luthra, S., Shamblin, S. L., Arora, K., Krzyzaniak, J. F., and Taylor, L. S. (2018). Assessing the risk of salt disproportionation using crystal structure and surface topography analysis. Crystal Growth and Design. 18(11):7027-7040. http://dx.doi.org/10.1021/acs.cgd.8b01188
268. Thorat, A. A., Forny, L., Meunier, V., Taylor, L. S., and Mauer, L. J. (2018). Effects of Mono-, Di-, and Tri-saccharides on the Stability and Crystallization of Amorphous Sucrose. Journal of Food Science. 83(11):2827-2839. http://dx.doi.org/10.1111/1750-3841.14357
267. Dening, T. J., and Taylor, L. S. Supersaturation Potential of Ordered Mesoporous Silica Delivery Systems. Part 1: Dissolution Performance and Drug Membrane Transport Rates. (2018) Molecular Pharmaceutics. 15(8):3489-3501. http://dx.doi.org/10.1021/acs.molpharmaceut.8b00488
266. Voelker, A., Miller, J., Running, C.A., Taylor, L. S. and Mauer, L. J. Chemical stability and reaction kinetics of two thiamine salts (thiamine mononitrate and thiamine chloride hydrochloride) in solution. (2018). Food Research International. 112:443-456. http://dx.doi.org/10.1016/j.foodres.2018.06.056
265. Indulkar, A. S., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S.(2018). Crystallization from supersaturated solutions: Role of lecithin and composite simulated intestinal fluid. Pharmaceutical Research. 35(8):158. http://dx.doi.org/10.1007/s11095-018-2441-2
264. Mugheirbi, N. A., Mosquera-Giraldo, L. I., Borca, , Slipchenko, L.V, and Taylor, L. S. (2018). Phase Behavior of Drug-Hydroxypropyl Methylcellulose Amorphous Solid Dispersions Produced from Various Solvent Systems: Mechanistic Understanding of the Role of Polymer using Experimental and Theoretical Methods. Molecular Pharmaceutics. 15(8):3236-3251. http://dx.doi.org/10.1021/acs.molpharmaceut.8b00324
263. Arca, H., C., Bi, V., Mosquera-Giraldo, L. I., Xu, D., Taylor, L. S., and Edgar, K. J. (2018). Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters.Biomacromolecules. 19(7):2351-2376. http://dx.doi.org/10.1021/acs.biomac.8b00517
262. Patel, M. A., Luthra, S., Shamblin, S. L., Arora, K., Krzyzaniak, J. F., and Taylor, L. S. (2018).Effect of excipient properties, water activity, and water content on the disproportionation of a pharmaceutical salt. International Journal of Pharmaceutics. 546 (1-2): 226-234. http://dx.doi.org/10.1016/j.ijpharm.2018.05.035
261. Bhujbal, S.V., Zemlyanov, D.Y., Cavallaro, A., Mangal, S., Taylor, L. S. and Zhou, Q. T. (2018). Qualitative and Quantitative Characterization of Composition Heterogeneity on the Surface of Spray Dried Amorphous Solid Dispersion Particles by an Advanced Surface Analysis Platform with High Surface Sensitivity and Superior Spatial Resolution. Molecular Pharmaceutics. 15(5):2045-2053. http://dx.doi.org/10.1021/acs.molpharmaceut.8b00122
260. Li, N., and Taylor, L.S. Tailoring supersaturation from amorphous solid dispersions. (2018) Journal of Controlled Release. http://dx.doi.org/10.1016/j.jconrel.2018.04.014
259. Tres, F., Posada, M. M., Hall, S. D., Mohutsky, M. A., and Taylor, L. S. (2018). Mechanistic Understanding of the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs. International Journal of Pharmaceutics. 543 (1-2):29-37. http://dx.doi.org/10.1016/j.ijpharm.2018.03.038
258. Mosquera-Giraldo, L. I., Li, N., Wilson, V. R., Nichols, B. L. B., Edgar, K. J., and Taylor, L. S. (2018). Influence of Polymer and Drug Loading on the Release Profile and Membrane Transport of Telaprevir. Molecular Pharmaceutics. 15(4):1700-1713. http://dx.doi.org/10.1021/acs.molpharmaceut.8b00104
257. Sugihara, H. and Taylor, L. S. (2018). Evaluation of Pazopanib Phase Behavior Following pH-Induced Supersaturation. Molecular Pharmaceutics. 15(4):1690-1699 http://dx.doi.org/10.1021/acs.molpharmaceut.8b00081
256. Liu, S., Gao, C., Mosquera-Giraldo, L. I., Taylor, L. S., and Edgar, K. J. (2018). Selective Synthesis of Curdlan Omega Carboxyamides by Staudinger Ylide Nucleophilic Ring-opening. Carbohydrate Polymers. 190:222-231. http://dx.doi.org/10.1016/j.carbpol.2018.02.074
255. Que, C., Gao, Y., Raina, S. A., Zhang, G. Z. Z., and Taylor, L. S. (2018). Paclitaxel Crystal Seeds with Different Intrinsic Properties and Their Impact on Dissolution of Paclitaxel-HPMCAS Amorphous Solid Dispersions. Crystal Growth and Design. 18(3):1548-1559. http://dx.doi.org/10.1021/acs.cgd.7b01521
254. Bhardwaj, V., Trasi, N. S., Zemlyanov, D. Y., and Taylor, L. S. (2018). Surface area normalized dissolution to study differences in itraconazole-copovidone solid dispersions prepared by spray-drying and hot melt extrusion. International Journal of Pharmaceutics. 540(1-2):106-119. http://dx.doi.org/10.1016/j.ijpharm.2018.02.005
253. Purohit, H., Trasi, N. S., Sun, D. D., Chow, E. C. Y., Wen, H., Zhang, X., Gao, Y., and Taylor, L. S.(2018). Investigating the impact of drug crystallinity in amorphous tacrolimus capsules on pharmacokinetics and bioequivalence using discriminatory in vitro dissolution testing and PBPK modeling and simulation. Journal of Pharmaceutical Sciences. 107(5):1330-1341. http://dx.doi.org/10.1016/j.xphs.2017.12.024
252. Tres, F., Hall, S. D., Mohutsky, M. A., and Taylor, L. S. (2018). Monitoring the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs Using Fluorescence Techniques. Journal of Pharmaceutical Sciences. 107(1):94-102. http://dx.doi.org/10.1016/j.xphs.2017.10.002
251. Winslow, C. J., Nichols, B. L. B, Novo, D. C. , Mosquera-Giraldo, L. I. , Taylor, L. S., Edgar, K. J., and Neilson, A. P. (2018). Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro. Carbohydrate Polymers. 182(15):149-158. http://dx.doi.org/10.1016/j.carbpol.2017.11.024
250. Patel, M. A., Luthra, S., Shamblin, S. L., Arora, K., Krzyzaniak, J. F., and Taylor, L. S. (2018) Impact of solid-state form on the disproportionation of miconazole mesylate. Molecular Pharmaceutics. 15(1):40-52. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00694
249. Kalra, A., Luner, P., Taylor, L. S., Byrn, S. R., and Li, T. (2018). Gaining Thermodynamic Insight from Distinct Glass Formation Kinetics of Structurally Similar Organic Compounds. Journal of Pharmaceutical Sciences. 107(1):192-202. http://dx.doi.org/10.1016/j.xphs.2017.06.012
248. Elkhabaz, A., Sarkar, S., Dinh, J. K., Simpson, G. J., and Taylor, L.S. (2018) Variation in the Supersaturation and Phase Behavior of Ezetimibe Amorphous Solid Dispersions Upon Dissolution in Different Biorelevant Media. Molecular Pharmaceutics. 15(1):193-206. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00814
247. Arca, H., C., Mosquera-Giraldo, L. I., Pereira, J. M. Sriranganathan, N., Taylor, L. S., Edgar, K. J. (2018). Rifampin Stability and Solution Concentration Enhancement through Amorphous Solid Dispersion in Cellulose ω-Carboxyalkanoate Matrices. Journal of Pharmaceutical Sciences. 107(1):127-138. http://dx.doi.org/10.1016/j.xphs.2017.05.036
246. Alin, J., Setiawan, N., Defrese, M., DiNunzio, J., Lau, H., Lupton, L., Xi, H., Su, Y., Nie, H., Hesse, N., Taylor, L. S., and Marsac, P. J. (2018) A novel approach for measuring room temperature enthalpy of mixing and associated solubility estimation of a drug in a polymer matrix. Polymer. 135(17):50-60. http://dx.doi.org/10.1016/j.polymer.2017.11.056
245. Thorat, A. A., Forny, L., Meunier, V., Taylor, L. S., and Mauer, L. J. (2017) Effects of chloride and sulfate salts on the inhibition or promotion of sucrose crystallization in initially amorphous sucrose-salt blends.. Journal of Agricultural and Food Chemistry. 65(51):11259-11272. http://dx.doi.org/10.1021/acs.jafc.7b04746
244. Tian, B., Gao, W., Tao, X., Tang, X., and Taylor, L. S. (2017) Impact of Polymers on the Melt Crystal Growth Rate of Indomethacin Polymorphs. Crystal Growth and Design. 17(12):6467-6476. http://dx.doi.org/10.1021/acs.cgd.7b01145
243. Mugheirbi, N. A., Marsac, P. J. and Taylor, L. S. (2017) Insights into Water-Induced Phase Separation in Itraconazole-hydroxypropylmethyl cellulose Spin Coated and Spray Dried Dispersions. Molecular Pharmaceutics. 14(12):4387-4402. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00499
242. Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2017) Absorptive Dissolution Testing of Supersaturating Systems: Impact of Absorptive Sink Conditions on Solution Phase Behavior and Mass Transport. Molecular Pharmaceutics. 14(11):4052-4063. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00740
241. Purohit, H. S., and Taylor, L. S. (2017). Phase Behavior of Ritonavir Amorphous Solid Dispersions During Hydration and Dissolution. Pharmaceutical Research. 34(12):2842-2861. http://dx.doi.org/10.1007/s11095-017-2265-5
240. Arca, H., C., Mosquera-Giraldo, L. I., Dahal, D., Taylor, L. S., and Edgar, K. J. (2017). Multidrug, Anti-HIV Amorphous Solid Dispersions: Nature and Mechanisms of Impacts of Drugs on Each Other's Solution Concentrations. Molecular Pharmaceutics. 14(11):3617-3627. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00203
239. Mugheirbi, N. A., O'Connel, P., Taylor, L. S., and Tajber, L. (2017) A comparative study on the performance of inert and functionalized spheres coated with solid dispersions made of two structurally related antifungal drugs. Molecular Pharmaceutics. 14(11):3718-3728. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00482
238. Correa-Soto, C., Trasi, N. S., Schmitt, P. D. Su, Y., Liu, Z., Variankaval, N., Marsac, P. J., Simpson, G. J., and Taylor, L. S. (2017). Second Harmonic Generation Microscopy as a Tool for the Early Detection of Crystallization in Spray Dried Dispersions. Journal of Pharmaceutical and Biomedical Analysis. 146:86-95. http://dx.doi.org/10.1016/j.jpba.2017.07.066
237. Xie, T., Gao, W., and Taylor, L. S. (2017). Impact of Eudragit EPO and Hydroxypropyl Methylcellulose on Drug Release Rate, Supersaturation, Precipitation Outcome and Redissolution Rate of Indomethacin Amorphous Solid Dispersions. International Journal of Pharmaceutics. 531(1):313-323. http://dx.doi.org/10.1016/j.ijpharm.2017.08.099
236. Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Patel, S., Litster, J. D., and Taylor, L. S. (2017). Compositional Effect of Complex Biorelevant Media on the Crystallization Kinetics of an Active Pharmaceutical Ingredient. CrystEngComm. 19:4797-4806. http://dx.doi.org/10.1039/C7CE01128H
235. Saboo, S., and Taylor, L. S. (2017). Water-induced Phase Separation of Miconazole-Poly (Vinylpyrrolidone-Co-Vinyl Acetate) Amorphous Solid Dispersions: Insights with Confocal Fluorescence Microscopy. International Journal of Pharmaceutics. 529(1-2):654-666. http://dx.doi.org/10.1016/j.ijpharm.2017.07.034
234. Trasi, N. S., Purohit, H., and Taylor, L. S. (2017). Evaluation of the Crystallization Tendency of Commercially Available Amorphous Tacrolimus Formulations Exposed to Different Stress Conditions. Pharmaceutical Research. 34(10):2142-2155. http://dx.doi.org/10.1007/s11095-017-2221-4
233. Arioglu-Tuncil, S., Bhardwaj, V., Taylor, L. S. and Mauer, L. J. (2017). The Crystallization Inhibitor Properties of Different Polymers in Thiamine Chloride Hydrochloride Amorphous Solid Dispersions. Food Research International. 99(1):263-374. http://dx.doi.org/10.1016/j.foodres.2017.05.021
232. Indulkar, A. S., Waters, J. E., Mo, H., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2017). Origin of Nanodroplet Formation upon Dissolution of an Amorphous Solid Dispersion: A Mechanistic Isotope Scrambling Study. Journal of Pharmaceutical Sciences. 106(8):1998-2008. http://dx.doi.org/10.1016/j.xphs.2017.04.015
231. Kalra, A., Tishmack, P., Lubach, J. W., Munson, E., Taylor, L. S., Byrn, S. R., and Li, T. (2017). Impact of Supramolecular Aggregation on the Crystallization Kinetics of Organic Compounds from the Supercooled Liquid State. Molecular Pharmaceutics. 14(6):2126–2137. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00245
230. Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Patel, S., Litster, J. D., and Taylor, L. S. (2017). Impact of Bile Salts on Solution Crystal Growth Rate and Residual Supersaturation of an Active Pharmaceutical Ingredient. Crystal Growth and Design. 17(6):3528–3537. http://dx.doi.org/10.1021/acs.cgd.7b00464
229. Purohit, H.S., Ormes, J. D., Saboo, S., Su, Y., Lamm, M. S., Mann, A. K. P., and Taylor, L. S. (2017). Insights into Nano- and Micron-scale Phase Separation in Amorphous Solid Dispersions using Fluorescence-based Techniques in Combination with Solid State Nuclear Magnetic Resonance Spectroscopy. Pharmaceutical Research. 34(7):1364-1377. http://dx.doi.org/10.1007/s11095-017-2145-z
228. Li, N., Gilpin, C. J. and Taylor, L. S. (2017) Understanding the impact of water on the miscibility and microstructure of amorphous solid dispersions – An AFM/LCR and TEM/EDX study. Molecular Pharmaceutics. 14(5):1691–1705. http://dx.doi.org/10.1021/acs.molpharmaceut.6b01151
227. Dong, Y., Mosquera-Giraldo, L.I., Taylor, L.S., and Edgar, K. J. (2017). Tandem Modification of Amphiphilic Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-metathesis and Thiol-Michael Addition. Polymer Chemistry. 8:3129-3139. http://dx.doi.org/10.1039/C7PY00228A
226. Icten, E., Purohit, H. S., Wallace, C., Giridhar, A., Taylor, L. S., Nagy, Z. K., Reklaitis, G. V. (2017). Dropwise Additive Manufacturing of Pharmaceutical Products for Amorphous and Self Emulsifying Drug Delivery Systems. International Journal of Pharmaceutics. 524(1-2):424-432. http://dx.doi.org/10.1016/j.ijpharm.2017.04.003.
225. Indulkar, A. S., Mo, H., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2017). Impact of micellar surfactant on supersaturation and insight into solubilization mechanisms in supersaturated solutions. Pharmaceutical Research. 34(6):1276-1296. http://dx.doi.org/10.1007/s11095-017-2144-0
224. Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Litster, J. D., and Taylor, L. S. (2017). Maintaining Supersaturation of Active Pharmaceutical Ingredient Solutions with Biologically Relevant Bile Salts. Crystal Growth and Design. 17(5):2782–2791. http://dx.doi.org/10.1021/acs.cgd.7b00237
223. Thorat, A., Marrs, K. N., Ghorab, M. K., Meunier, V., Forny, L., Taylor, L. S, and Mauer, L. J. (2017). Moisture-Mediated Interactions between Amorphous Maltodextrins and Crystalline Fructose. Journal of Food Science. 82(5):1142–1156. http://dx.doi.org/10.1111/1750-3841.13676
222. Lu, J., Ormes, J. D., Lowinger, M., Xu, W., Mitra, A., Mann, A. K. P., Litster, J. D., and Taylor, L. S. (2017). Impact of Endogenous Bile Salts on the Thermodynamics of Supersaturated Active Pharmaceutical Ingredient Solutions. Crystal Growth and Design. 17(3):1264-1275. http://dx.doi.org/10.1021/acs.cgd.6b01664
221. Arca, H.C., Mosquera-Giraldo, L.I., Taylor, L.S., and Edgar, K. J. (2017). Synthesis and characterization of alkyl cellulose ω-carboxyesters for amorphous solid dispersion. Cellulose. 24:609-625. http://dx.doi.org/10.1007/s10570-016-1156-y
220. Nie, H., Xu, W., Taylor, L. S., Marsac, P. J., and Byrn, S. R. (2017). Crystalline solid dispersion-a strategy to slowdown salt disproportionation in solid state formulations during storage and wet granulation. International Journal of Pharmaceutics. 517(1-2):203-215. http://dx.doi.org/10.1016/j.ijpharm.2016.12.014
219. Sato, T. and Taylor, L. S. (2017). Acceleration of the crystal growth rate of low molecular weight organic compounds in supercooled liquids in the presence of polyhydroxybutylate. CrystEngComm. 19:80-87. http://dx.doi.org/10.1039/C6CE02177H
218. Gilley, A. D., Arca, H. C., Nichols, B. L. B., Mosquera-Giraldo, L. I., Taylor, L. S., Edgar, K. J., Neilson, A. P. (2107). Novel Cellulose-Based Amorphous Solid Dispersions Enhance Quercetin Solution Concentrations In Vitro. Carbohydrate Polymers. 157:86-93. http://dx.doi.org/10.1016/j.carbpol.2016.09.067
217. Xie, T., and Taylor, L. S. (2017). Effect of Temperature and Moisture on the Physical Stability of Binary and Ternary Amorphous Solid Dispersions of Celecoxib. Journal of Pharmaceutical Sciences. 106(1):100-110. http://dx.doi.org/10.1016/j.xphs.2016.06.017
216. Trasi, N. S., Purohit, H. S., Wen, H., Sun, D. D., and Lynne S. Taylor (2017). Non-sink dissolution behavior and solubility limit of commercial tacrolimus amorphous formulations. Journal of Pharmaceutical Sciences. 106(1):264-272. http://dx.doi.org/10.1016/j.xphs.2016.09.016
215. Taylor, L. S., Rantanen, J., Paradkar, A., Kawashima, Y., and Zhang, J. (2017). Professor Peter York- A distinguished career in powders, processing and particle design. Journal of Pharmaceutical Sciences. 106(1):2-4. http://dx.doi.org/10.1016/j.xphs.2016.09.006
214. Li, N., Mosquera-Giraldo, L. I., Borca, C. H., Ormes, J. D., Lowinger, M. Higgins, J. D., Slipchenko, L.V., and Taylor, L. S. (2016). A Comparison of the Crystallization Inhibition Properties of Bile Salts. Crystal Growth and Design. 16(12):7286-7300. http://dx.doi.org/10.1021/acs.cgd.6b01470
213. Tian, B., Tang, X., and Taylor, L. S. (2016). Investigating the Correlation between Miscibility and Physical Stability of Amorphous Solid Dispersions Using Fluorescence-based Techniques. Molecular Pharmaceutics. 13(11):3988-4000. http://dx.doi.org/10.1021/acs.molpharmaceut.6b00803
212. Mosquera-Giraldo, L. I., Borca, C. H., Meng, X., Edgar, K. J., Slipchenko, L.V, and Taylor, L. S. (2016). Mechanistic Design of Chemically Diverse Polymers with Applications in Oral Drug Delivery. Biomacromolecules. 17(11):3659-3671. http://dx.doi.org/10.1021/acs.biomac.6b01156
211. Nie, H., Su, Y., Zhang, M., Song, Y., Leone, A., Taylor, L.S., Marsac, P. J., Li, T., and Byrn, S. R. (2016). Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions. Molecular Pharmaceutics. 13(11):3964-3975. http://dx.doi.org/10.1021/acs.molpharmaceut.6b00740
210. Lu, M. and Taylor, L. S. (2016). Vemurafenib: A Tetramorphic System Displaying Concomitant Crystallization from the Supercooled Liquid. Crystal Growth and Design. 16(10):6033-6042. http://dx.doi.org/10.1021/acs.cgd.6b01066
209. Nie, H., Xu, W., Ren, J., Taylor, L. S., Marsac, P. J., John, C. T., and Byrn, S. R. (2016). Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. Molecular Pharmaceutics. 13(10):3541-3552. http://dx.doi.org/10.1021/acs.molpharmaceut.6b00630
208. Dong, Y., Mosquera-Giraldo, L. I, Troutman, J., Skogstad, B., Taylor, L. S. and Edgar, K. J. (2016). Amphiphilic Hydroxyalkyl Cellulose Derivatives for Amorphous Solid Dispersion Prepared by Olefin Cross-Metathesis. Polymer Chemistry. 7:4953-4963.http://dx.doi.org/10.1039/C6PY00960C
207. Sun, D. D., Wen, H. and Taylor, L. S. (2016). Non-sink dissolution conditions for predicting product quality and in vivo performance of supersaturating drug delivery systems. Journal of Pharmaceutical Sciences.105(9):2477-2488. http://dx.doi.org/10.1016/j.xphs.2016.03.024
206. Indulkar, A. S., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2016). Exploiting the phenomenon of liquid-liquid phase separation for enhanced and sustained membrane transport of a poorly water soluble drug. Molecular Pharmaceutics. 13(6):2059-2069. http://dx.doi.org/10.1021/acs.molpharmaceut.6b00202
205. Schram, C. J., Smyth, R. J., Taylor, L. S. and Beaudoin, S. P. (2016). Understanding Crystal Growth Kinetics in the Absence and Presence of a Polymer Using a Rotating Disk Apparatus. Crystal Growth and Design. 16(5):2640-2645. http://dx.doi.org/10.1021/acs.cgd.5b01729
204. Li, N., Ormes, J. D. and Taylor, L. S. (2016). Leaching of Lopinavir Amorphous Solid Dispersions in Acidic Media. Pharmaceutical Research. 33(7):1723-1735. http://dx.doi.org/10.1007/s11095-016-1913-5
203. Taylor, L. S. and Zhang, G. G. Z. (2016) Physical Chemistry of Supersaturated Solutions and Implications for Oral Absorption. Advanced Drug Delivery Reviews. 101:122-142. http://dx.doi.org/10.1016/j.addr.2016.03.006
202. Alhalaweh, A., Bergström, C. A. S. and Taylor, L. S. (2016). Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations. Journal of Controlled Release.229:172-182. http://dx.doi.org/10.1016/j.jconrel.2016.03.028
201. Jackson, M. J., Kestur, U. S., Hussain, M. A., and Taylor, L. S. (2016). Characterization of Highly Supersaturated Danazol Solutions – Impact of Polymers on Solution Properties and Phase Transitions. Pharmaceutical Research. 33(5):1276-1288. http://dx.doi.org/10.1007/s11095-016-1871-y
200. Li., N. and Taylor, L. S. (2016). Nanoscale Infrared, Thermal, and Mechanical Characterization of Telaprevir-Polymer Miscibility in Amorphous Solid Dispersions Prepared by Solvent Evaporation. Molecular Pharmaceutics. 13(3):1123-1136. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00925
199. Schram, C. J., Beaudoin, S. P. and Taylor, L. S. (2016). Polymer Inhibition of Crystal Growth by Surface Poisoning. Crystal Growth and Design. 16(4):2094-2103. http://dx.doi.org/10.1021/acs.cgd.5b01779
198. Xie, T., and Taylor, L. S. (2016). Improved Release of Celexocib from High Drug Loading Amorphous Solid Dispersions Formulated with Polyacrylic Acid and Cellulose Derivatives. Molecular Pharmaceutics.13(3):873-884. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00798
197. Almeida e Sousa, L., Reutzel-Edens, S. M., Stephenson, G. A. and Taylor, L. S. (2016). Supersaturation Potential of Salt, Co-Crystal and Amorphous Forms of a Model Weak Base. Crystal Growth and Design. 16(2):737-748. http://dx.doi.org/10.1021/acs.cgd.5b01341
196. Dong, Y., Mosquera-Giraldo, L. I., Taylor, L. S. and Edgar, K. J. (2016). Design of Functionalized Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-Metathesis. Biomacromolecules. 17(2):454-465. http://dx.doi.org/10.1021/acs.biomac.5b01336
195. Jackson, M. J., Kestur, U. S., Hussain, M. A., and Taylor, L. S. (2016). Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type. Molecular Pharmaceutics. 13(1):223-231. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00652
194. Xie, T., and Taylor, L. S. (2016). Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations. Pharmaceutical Research. 33(3):739-750. http://dx.doi.org/10.1007/s11095-015-1823-y
193. Nie, H., Liu, Z., Marks, B. C., Taylor, L. S., Byrn, S. R. and Marsac, P. J. (2016). Analytical Approaches to Investigate Salt Disproportionation in Tablet Matrices by Raman Spectroscopy and Raman Mapping. Journal of Pharmaceutical and Biomedical Analysis. 118:328-337. http://dx.doi.org/10.1016/j.jpba.2015.10.024
192. Allan, M., Taylor, L. S. and Mauer, L. J. (2016). Common-Ion Effects on the Deliquescence Lowering of Crystalline Ingredient Blends. Food Chemistry. 195:2-10. http://dx.doi.org/10.1016/j.foodchem.2015.04.063
191. Li, N., Taylor, L. S. and Mauer, L. J. (2016). Heat Transport Model for the Deliquescence Kinetics of Crystalline Ingredients and Mixtures. Journal of Food Engineering. 169:298-308. http://dx.doi.org/10.1016/j.jfoodeng.2015.08.013
190. Purohit, H. S. and Taylor, L. S. (2015). Miscibility of Itraconazole-Hydroxypropyl Methylcellulose Blends- Insights with High Resolution Analytical Methodologies. Molecular Pharmaceutics. 12(12):4542-4542. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00761
189. Trasi, N. and Taylor, L. S. (2015). Dissolution Performance of Binary Amorphous Drug Combinations – Impact of a Second Drug on the Maximum Achievable Supersaturation. International Journal of Pharmaceutics. 496(2):282-290. http://dx.doi.org/10.1016/j.ijpharm.2015.10.026
188. Schram, C. J., Taylor, L. S. and Beaudoin, S. P. (2015). Influence of Polymers on the Crystal Growth Rate of Felodipine – Correlating Adsorbed Polymer Surface Coverage to Solution Crystal Growth Inhibition. Langmuir. 31(41):11279-11287. http://dx.doi.org/10.1021/acs.langmuir.5b02486
187. Liu, H., Taylor, L. S. and Edgar, K. E. (2015). The Role of Polymers in Oral Bioavailability Enhancement; A Review. Polymer. 77:399-415. http://dx.doi.org/10.1016/j.polymer.2015.09.026
186. Raina, S. A., Alonzo, D. E., Zhang, G. G. Z., Gao, Y. and Taylor, L. S. (2015). Using Environment-Sensitive Fluorescent Probes to Characterize Liquid-Liquid Phase Separation in Supersaturated Solutions of Poorly Water Soluble Compounds. Pharmaceutical Research. 32(11):3660-3673. http://dx.doi.org/10.1007/s11095-015-1725-z
185. Schmitt, P. D., Trasi, N. S., Taylor, L. S. and Simpson, G. J. Finding the Needle in the Haystack – Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy. (2015) Molecular Pharmaceutics. 12(7):2378-2383. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00065
184. Sato, T. and Taylor, L. S. (2015). Chiral Discrimination by a Cellulose Polymer: Differential Crystallization Inhibition of Enantiomers in Amorphous Dispersions. CrystEngComm. 17:5046-5053. http://dx.doi.org/10.1039/C5CE00810G
183. Trasi, N. S. and Taylor, L. S. (2015). Thermodynamics of Highly Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs – Impact of a Second Drug on the Solution Phase Behavior and Implications for Combination Products. Journal of Pharmaceutical Sciences. 104(8):2583-2593. http://dx.doi.org/10.1002/jps.24528
182. Raina, S. A., Zhang, G. G. Z., Alonzo, D. E., Wu, J., Zhu, D., Catron, N. D., Gao, Y. and Taylor, L. S. (2015). Impact of Solubilizing Additives on Supersaturation and Membrane Transport of Drugs. Pharmaceutical Research. 32(10):3350-3364. http://dx.doi.org/10.1007/s11095-015-1712-4
181. Christina, B., Taylor, L. S., and Mauer, L. J. (2015). Physical stability of L-ascorbic acid amorphous solid dispersions in different polymers: a study of polymer crystallization inhibitor properties. Food Research International. 76(3):867-877. http://dx.doi.org/10.1016/j.foodres.2015.08.009
180. Nie, H., Mo, H., Zhang, M., Song, Y., Fang, K., Taylor, L. S. Li, T. and. Byrn, S. R. (2015). Investigating the interaction pattern and structural elements of a drug-polymer complex at the molecular level. Molecular Pharmaceutics. 12(7)2459-2468. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00162
179. Indulkar, A., Box, K. J., Taylor, R., Ruiz, R., and Taylor, L. S. (2015). pH-Dependent Liquid-Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs. Molecular Pharmaceutics. 12(7):2365-2377. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00056
178. Wegiel, L.A., Mosquera-Giraldo L.,Mauer, L.J. , Edgar, K.J., and Taylor, L.S. (2015) Phase Behavior of Resveratrol Solid Dispersions Upon Addition to Aqueous Media. Pharmaceutical Research. 32(10):3324-3337. http://dx.doi.org/10.1007/s11095-015-1709-z
177. Chen, J., Mosquera-Giraldo L., Ormes, J. D., Higgins, J. D. and Taylor, L. S. (2015). Bile Salts as Crystallization Inhibitors of Supersaturated Solutions of Poorly Water-Soluble Compounds. Crystal Growth and Design. 15(6):2593-2597. http://dx.doi.org/10.1021/acs.cgd.5b00392
176. Hsieh, Y-L., Merritt, J. M.; Yu, W., and Taylor, L. S. Salt Stability – The Effect of pHmax on Salt to Free Base Conversion. (2015). Pharmaceutical Research. 32(9):3110-3118. http://dx.doi.org/10.1007/s11095-015-1691-5
175. Purohit, H. S. and Taylor, L. S. Phase Separation Kinetics in Amorphous Solid Dispersions Upon Exposure to Water. (2015) Molecular Pharmaceutics. 12(5):1623-1635. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00041
174. Raina, S. A., Van Eerdenbrugh, B., Alonzo, D. E., Mo, H., Zhang, G. G. Z., Gao, Y. and Taylor, L. S. (2015). Trends in the Precipitation and Crystallization Behavior of Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs Assessed using Synchrotron Radiation. Journal of Pharmaceutical Sciences. 104(6):1981-1992. http://dx.doi.org/10.1002/jps.24423
173. Içten, E., Giridhar, A., Taylor, L. S., Nagy, Z. K., Reklaitis, G. V. (2015). Dropwise Additive Manufacturing of Pharmaceutical Products for Melt-Based Dosage Forms. Journal of Pharmaceutical Sciences. 104(5):1641-1649. http://dx.doi.org/10.1002/jps.24367
172. Toth, S., Schmitt, P. D., Snyder, G. R., Trasi, N. S., George, I. A., Taylor, L. S. and Simpson, G. J. (2015) Ab Initio Prediction of the Diversity of Second Harmonic Generation from Pharmaceutically Relevant Materials. Crystal Growth and Design. 15(2):581-586. http://dx.doi.org/10.1021/acs.cgd.5b00020
171. Chen, J., Ormes, J. D., Higgins, J. D. and Taylor, L. S. (2015) Impact of Surfactants on the Crystallization of Aqueous Suspensions of Celecoxib Amorphous Solid Dispersion Spray Dried Particles. Molecular Pharmaceutics. 12(2):533-541. http://dx.doi.org/10.1021/mp5006245
170. Mosquera-Giraldo L., and Taylor, L. S. Glass-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Telaprevir. (2015) Molecular Pharmaceutics. 12(2):496-501. http://dx.doi.org/10.1021/mp500573z
169. Trasi, N. S., Abbou-Oucherif, K., Litster, J. D. and Taylor, L. S. (2015) Evaluating the Influence of Polymers on Nucleation and Growth in Supersaturated Solutions of Acetaminophen. CrystEngComm. 17:1242-1248. http://dx.doi.org/10.1039/C4CE02179G
168. Almeida e Sousa, L., Reutzel-Edens, S. M., Stephenson, G. A. and Taylor, L. S. (2015). Assessment of the Amorphous "Solubility" of a Group of Diverse Drugs Using New Experimental and Theoretical Approaches. Molecular Pharmaceutics. 12(2):484-495. http://dx.doi.org/10.1021/mp500571m
167. Schram, C. J., Beaudoin, S. P. and Taylor, L. S. (2015). Impact of Polymer Conformation on the Crystal Growth Inhibition of a Poorly Water Soluble Drug in Aqueous Solution. Langmuir. 31(1):171-179. http://dx.doi.org/10.1021/la503644m
166. Hsu, H-Y, Adigun, O. O., Taylor, L. S., Murad, S. and Harris, M. T. (2015). Impact of Surface Chemistry on Crystallization of Acetaminophen. Chemical Engineering Science. 126:1-9. http://dx.doi.org/10.1016/j.ces.2014.10.046
165. Lipasek, R.A., Li, N., Taylor, L. S. and Mauer, L. J. (2015) Effect of temperature and initial moisture content on the chemical stability and color change of various forms of vitamin C. International Journal of Food Properties. 18(4):862-879. http://dx.doi.org/10.1080/10942912.2013.805770
164. Hsieh, Y-L., and Taylor, L. S. (2015). Salt Stability - Effect of Particle Size, Relative Humidity, Temperature and Composition on Salt to Free Base Conversion. Pharmaceutical Research. 32(2):549-561. http://dx.doi.org/10.1007/s11095-014-1484-2
163. Raina, S. A., Alonzo, D. E., Zhang, G. G. Z., Gao, Y. and Taylor, L. S. (2014). Impact of Polymers on the Crystallization and Phase Transition Kinetics of Amorphous Nifedipine during Dissolution in Aqueous Media. Molecular Pharmaceutics. 11(10):3565-3576. http://dx.doi.org/10.1021/mp500333v
162. Jackson, M. J., Toth S. J., Kestur, U. S., Huang, J. Qian, F., Hussain, M. A. Simpson, G. J., and Taylor, L. S. (2014). Impact of Polymers on the Precipitation Behavior of Highly Supersaturated Aqueous Danazol Solutions. Molecular Pharmaceutics. 11(9):3027-3038. http://dx.doi.org/10.1021/mp500201s
161. Trasi, N., Baird, J. A. and Kestur, U. S. and Taylor, L. S. (2014). Factors Influencing Crystal Growth Rates from Undercooled Liquids of Pharmaceutical Compounds. Journal of Physical Chemistry B. 118(33):9974-9982. http://dx.doi.org/10.1021/jp504450h
160. Marks, J., Wegiel, L. A., Taylor, L. S. and Edgar, K. J. (2014). Pairwise Polymer Blends for Oral Drug Delivery. Journal of Pharmaceutical Sciences. 103(9):2871-2883. http://dx.doi.org/10.1002/jps.23991
159. Taylor, L. S. and Hancock, B. C. (2014) George Zografi and the Science of Solids and Surfaces. Journal of Pharmaceutical Sciences. 103(9):2592-2594. http://dx.doi.org/10.1002/jps.24000
158. Trasi, N. and Taylor, L. S. (2014). Nucleation and Crystal Growth of Amorphous Nilutamide –Unusual Low Temperature Behavior. CrystEngComm. 16:7186-7195. http://dx.doi.org/10.1039/C4CE00118D
157. Hsieh, Y-L., Box, K. and Taylor, L. S. (2014). Assessing the Impact of Polymers on the pH-Induced Precipitation Behavior of Poorly Water Soluble Compounds using Synchrotron Wide Angle X-Ray Scattering. Journal of Pharmaceutical Sciences. 103(9):2724-2735. http://dx.doi.org/10.1002/jps.23890
156. Raina, S. A., Zhang, G. G. Z., Alonzo, D. E., Wu, J., Zhu, D., Catron, N. D., Gao, Y. and Taylor, L. S. (2014). Enhancements and Limits in Drug Membrane Transport Using Supersaturated Solutions of Poorly Water Soluble Drugs. Journal of Pharmaceutical Sciences. 103(9):2736-2748. http://dx.doi.org/10.1002/jps.23826
155. Li, N., Taylor, L. S. and Mauer, L. J. (2014). The Physical and Chemical Stability of Amorphous (-)-Epi-Gallocatechin Gallate: Effects of Water Vapor Sorption and Storage Temperature. Food Research International. 58:112-123. http://dx.doi.org/10.1016/j.foodres.2014.01.043
154. Liu, H., Ilevbare, G. A., Cherniawskia, B. P., Ritchie, E. T., Taylor, L. S. and Edgar, K. J. (2014). Synthesis and Structure-property Evaluation of Cellulose ω-carboxyesters for Amorphous Solid Dispersions. Carbohydrate Polymers. 100:116-125. http://dx.doi.org/10.1016/j.carbpol.2012.11.049
153. Hirshfield, L., Giridhar, A., Taylor, L. S., Harris, M. T., Reklaitis, G. V. (2014). Dropwise Additive Manufacturing of Pharmaceutical Products for Solvent-Based Dosage Forms. Journal of Pharmaceutical Sciences. 103(2):496-506. http://dx.doi.org/10.1002/jps.23803
152. Mosquera-Giraldo L., Trasi, N. S., and Taylor, L. S. (2014) Impact of Surfactants on the Crystal Growth of Amorphous Celecoxib. International Journal of Pharmaceutics. 461(1-2):251-257. http://dx.doi.org/10.1016/j.ijpharm.2013.11.057
151. Hsieh, Y-L., Yu, W., Xiang, Y., Pan, W., Waterman, K. C., Shalaev, E. Y., Shamblin, S. L. and Taylor, L. S. (2014). Impact of Sertraline Salt Form on the Oxidative Stability in Powder Blends. International Journal of Pharmaceutics. 461(1-2):322-330. http://dx.doi.org/10.1016/j.ijpharm.2013.11.054
150. Van Eerdenbrugh, B., Raina, S. A., Hsieh, Y-L., Augustijns, P. and Taylor, L. S. (2014). Classification of the Crystallization Behavior of Amorphous Active Pharmaceutical Ingredients in Aqueous Environments. Pharmaceutical Research. 31(4):969-982. http://dx.doi.org/10.1007/s11095-013-1216-z
149. Wegiel, L.A., Mauer, L.J. , Edgar, K.J., and Taylor, L.S. (2014). Curcumin Amorphous Solid Dispersions: The Influence of Intra and Intermolecular Bonding on Physical Stability. Pharmaceutical Development and Technology. 19(8):976-986. http://dx.doi.org/10.3109/10837450.2013.846374
148. Wegiel, L.A., Mauer, L.J. , Edgar, K.J., and Taylor, L.S. (2014). Mid-Infrared Spectroscopy as a Polymer Selection Tool for Formulating Amorphous Solid Dispersions. Journal of Pharmacy and Pharmacology. 66(2):244-255. http://dx.doi.org/10.1111/jphp.12079
147. Ghorab, M.K, Marrs, K, Taylor, L. S. and Mauer, L. J. (2014) Water-Solid Interactions between Amorphous Maltodextrin and Crystalline Sodium Chloride. Food Chemistry. 144:26-35. http://dx.doi.org/10.1016/j.foodchem.2013.02.123
146. Ghorab, M.K, Toth, S J., Simpson, G. J., Mauer, L. J. and Taylor, L. S. (2014) Water-Solid Interactions in Amorphous Maltodextrin-Crystalline Sucrose Binary Mixtures. Pharmaceutical Development and Technology. 19(2):247-256. http://dx.doi.org/10.3109/10837450.2013.775157
145. Harrison A. J., Bilgili, E. A., Beaudoin, S. P. and Taylor, L. S. (2013) Atomic force microscope infrared spectroscopy of griseofulvin nanocrystals. Analytical Chemistry. 85(23):11449-11455. http://dx.doi.org/10.1021/ac4025889
144. Pereira, J. M., Mejia-Ariza, R., Ilevbare, G. A. McGettigan, H. E., Sriranganathan, N., Taylor, L. S., Davis, R. M. and Edgar, K. J. (2013) Interplay of Degradation, Dissolution and Stabilization of Clarithromycin and its Amorphous Solid Dispersions. Molecular Pharmaceutics. 10(12):4640-4653. http://dx.doi.org/10.1021/mp400441d
143. Kestur, U. S. and Taylor, L. S. (2013). Evaluation of the Crystal Growth Rate of Felodipine Polymorphs in the Presence and Absence of Additives as a Function of Temperature. Crystal Growth and Design. 13(10):4349-4354 http://dx.doi.org/10.1021/cg400708p
142. Ilevbare, G. A., Liu, H., Pereira, J., Edgar, K. J., Taylor, L.S. (2013). Influence of Additives on the Properties of Nanodroplets Formed in Highly Supersaturated Aqueous Solutions of Ritonavir. Molecular Pharmaceutics. 10(9):3392-3403. http://dx.doi.org/10.1021/mp400228x
141. Lipasek, R.A., Li, N., Schmidt, S. J. Taylor, L. S. and Mauer, L. J. (2013). Effect of Temperature on the Deliquescence Properties of Food Ingredients and Blends. Journal of Agriculture and Food Chemistry. 61(38):9241-2950. http://dx.doi.org/10.1021/jf402585t
140. Ilevbare, G. A. Liu, H, Edgar, K. J., Taylor, L.S. (2013). Impact of Polymers on the Crystal Growth Rate of Structurally Diverse Compounds from Aqueous Solution. Molecular Pharmaceutics. 10(6):2381–2393. http://dx.doi.org/10.1021/mp400029v
139. Ilevbare, G. A. and Taylor, L. S. (2013). Liquid-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly-Water Soluble Drugs – Implications for Solubility Enhancing Formulations. Crystal Growth and Design. 13(4):1497-1509. http://dx.doi.org/10.1021/cg301679h
138. Li, B., Konecke, S., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013) Both Solubility and Chemical Stability of Curcumin are Enhanced by Solid Dispersion in Cellulose Derivative Matrices. Cellulose. 98: 1108-1116. http://dx.doi.org/10.1016/j.carbpol.2013.07.017
137. Li, B., Liu, H., Amin, M., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013).Enhancement of Naringenin Solution Concentration by Solid Dispersion in Cellulose Derivative Matrices. Cellulose. 20(4): 2137-2149. http://dx.doi.org/10.1007/s10570-013-9970-y
136. Li, B., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013). Stability and Solubility Enhancement of Resveratrol in Spray Dried Solid Dispersion with Cellulose Derivative Matrices. Cellulose. 20(3):1249-1260. http://dx.doi.org/10.1007/s10570-013-9889-3
135. Maltaş, D. C., Kwok, K., Wang, P., Taylor, L. S. and Ben-Amotz, D. (2013) Rapid Classification of Pharmaceutical Ingredients with Raman Spectroscopy Using Compressive Detection Strategy with PLS-DA Multivariate Filters. Journal of Pharmaceutical and Biomedical Analysis.80:63-68. http://dx.doi.org/10.1016/j.jpba.2013.02.029
134. Zhou, Q., Toth, S J., Simpson, G. J., Hsu H-Y., Taylor L. S., Harris, M. T., (2013) Crystallization and Dissolution Behavior of Naproxen/Polyethylene Glycol Solid Dispersions. Journal of Physical Chemistry. 117(5):1494-1500. http://dx.doi.org/10.1021/jp3106716
133. Ilevbare, G. A., Liu, H, Edgar, K. J., Taylor, L.S. (2013). Maintaining Supersaturation in Aqueous Drug Solutions - Impact of Different Polymers on Induction Times. Crystal Growth and Design. 13(2):740-751. http://dx.doi.org/10.1021/cg301447d
132. Kestur, U. S., Ivanisevic, I, Alonzo, D. E. and Taylor, L. S. (2013). Influence of Particle Size on the Crystallization Kinetics of Amorphous Felodipine Powders. Powder Technology.236:197–204. http://dx.doi.org/10.1016/j.powtec.2012.02.010
131. Li, N., Taylor, L. S. Ferruzzi, M. G. and Mauer, L. J. (2013). Color and Chemical Stability of Tea Polyphenol (-)-Epigallocatechin-3-gallate in Solution and Solid States. Food Research International. http://dx.doi.org/10.1016/j.foodres.2012.11.019
130. Li, B., Konecke, S., Harich, K., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013). Solid Dispersion of Quercetin in Cellulose Derivative or PVP Matrix Influences both Solubility and Stability. Carbohydrate Polymers. 92(2):2033-2040. http://dx.doi.org/10.1016/j.carbpol.2012.11.073
129. Hsu, H-Y, Toth, S. J., Simpson, G. J., Taylor, L. S., Harris, M. T. (2013) Effect of Substrates on Naproxen\Polyvinylpyrrolidone Solid Dispersions Formed via the Drop Printing Technique. Journal of Pharmaceutical Sciences. 102(2):638-648. http://dx.doi.org/10.1002/jps.23397
128. Abbou Oucherif, K. Raina, S., Taylor, L. S. and Litster, J. (2013) Quantitative Analysis of the Inhibitory Effect of HPMC on Felodipine Crystallization Kinetics Using Population Balance Modeling. CrystEngComm. 15:2197-2205. http://dx.doi.org/10.1039/c2ce26490k
127. Christensen, N. P. A., Van Eerdenbrugh, B., Kwok, K., Taylor, L. S., Bond, A. D. Rades, T., Rantanen, J., Cornett, C. (2013) Rapid Insight into Heating-induced Phase Transformations in the Solid-state of the Calcium Salt of Atorvastatin using Multivariate Data Analysis.Pharmaceutical Research. 30(3):826-835. http://dx.doi.org/10.1007/s11095-012-0923-1
126. Li, B., Harich, K., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013) Stability and Solubility Enhancement of Ellagic Acid in Cellulose Ester Solid Dispersions. Carbohydrate Polymers.92:1443-1450. http://dx.doi.org/10.1016/j.carbpol.2012.10.051
125. Baird, J.A., Thomas, L.C., Aubuchon, S.R. and Taylor, L. S. (2013). Evaluating the Non-isothermal Crystallization Behavior of Organic Molecules from the Undercooled Melt State using Rapid Heat/Cool Calorimetry. CrystEngComm. 15(1):111-119. http://dx.doi.org/10.1039/C2CE26448J
124. Wegiel, L.A., Mauer, L.J. , Edgar, K.J., and Taylor, L.S.(2013) Crystallization of Amorphous Solid Dispersions of Resveratrol during Preparation and Storage – Impact of Different Polymers. Journal of Pharmaceutical Sciences. 102(1):171-184. http://dx.doi.org/10.1002/jps.23358
123. Back, K. R., Davey, R.J., Grecu, T., Hunter, C. A. and Taylor, L. S. (2012) Molecular Conformation and Crystallisation – The Case of Ethenzamide. Crystal Growth and Design. 12(12):6110-6117. http://dx.doi.org/10.1021/cg301244x
122. Ilevbare, G. A., Liu, H., Edgar, K. J., Taylor, L.S. (2012). The Effect of Binary Additive Combinations on Solution Crystal Growth of the Poorly Water-Soluble Drug, Ritonavir. Crystal Growth and Design.12(12):6050-6060. http://dx.doi.org/10.1021/cg301169t
121. Stoklosa, A. M., Lipasek, R. Taylor, L. S. and Mauer, L. J. (2012) Effects of Storage Conditions, Formulation, and Particle Size on Moisture Sorption and Flowability of Powders: a Study of Deliquescent Ingredient Blends. Food Research International. 49: 783-791. http://dx.doi.org/10.1016/j.foodres.2012.09.034
120. Kestur, U. S., Wanapun, D., Toth, S.J. , Wegiel, L. A., Simpson, G. J. and Taylor, L. S. (2012) Nonlinear Optical Imaging for Sensitive Detection of Crystals in Bulk Amorphous Powders. Journal of Pharmaceutical Sciences. 101(11):4201–4213. http://dx.doi.org/10.1002/jps.23280
119. Ilevbare, G. A. Liu, H, Edgar, K. J., Taylor, L.S. (2012). Inhibition of Solution Crystal Growth of Ritonavir by Cellulose Polymers – Factors Influencing Polymer Effectiveness. CrystEngComm. 14:6503-651. http://dx.doi.org/10.1039/C2CE25515D
118. Christensen, N. P. A., Rantanen, J., Cornett, C., and Taylor, L. S. (2012) Physical Stability of the Calcium Salt of Atorvastatin in the Presence of Acidic Excipients. European Journal of Pharmaceutics and Biopharmaceutics. 82:410-416. http://dx.doi.org/10.1016/j.ejpb.2012.07.003
117. Toth, S.J., Madden, J. T., and Taylor, L. S., Marsac, P.J., and Simpson, G. J. (2012) Selective Imaging of Active Pharmaceutical Ingredients in Powdered Blends with Common Excipients Utilizing Two-Photon Excited Ultraviolet-Fluorescence and Ultraviolet-Second Order Nonlinear Optical Imaging of Chiral Crystals. Analytical Chemistry. 84(14):5859-5875. http://dx.doi.org/10.1021/ac300917t
116. Trasi, N. S. and Taylor, L. S. (2012). Effect of Polymers on Nucleation and Crystal Growth of Amorphous Acetaminophen. CrystEngComm. 14(16):5188-5197. http://dx.doi.org/10.1039/C2CE25374G
115. Hsieh, Y-L., Ilevbare, G.A., Van Eerdenbrugh, B., Box, K., Sanchez-Felix, M. V. and Taylor, L. S. (2012) pH-Induced Precipitation Behavior of Weakly Basic Compounds – Determination of Extent and Duration of Supersaturation using Potentiometric Titration and Correlation to Solid State Properties. Pharmaceutical Research. 29(10):2738-2753. http://dx.doi.org/10.1007/s11095-012-0759-8
114. Trasi, N. S., and Taylor, L. S. (2012). Effect of Additives on Crystal Growth and Nucleation of Amorphous Flutamide. Crystal Growth and Design.12(6):3221-3230. http://dx.doi.org/10.1021/cg300370q
113. Ilevbare, G. A., Liu, H., Edgar, K. J., Taylor, L.S. (2012) Understanding Polymer Properties Important for Crystal Growth Inhibition – Impact of Chemically Diverse Polymers on Solution Crystal Growth of Ritonavir. Crystal Growth and Design. 12(6):3133-3143. http://dx.doi.org/10.1021/cg300325p
112. Van Eerdenbrugh, B., Lo, M., Kjoller, K., Marcott, C. and Taylor, L.S. (2012) Nanoscale Mid-Infrared Evaluation of the Miscibility Behavior of Blends of Dextran or Maltodextrin with Poly(vinylpyrrolidone). Molecular Pharmaceutics. 9(5):1459-1469. http://dx.doi.org/10.1021/mp300059z
111. Kwok, K. and Taylor, L. S. (2012). Analysis of Counterfeit Cialis® Tablets Using Raman Microscopy and Multivariate Curve Resolution. Journal of Pharmaceutical and Biomedical Analysis.66:126-135. http://dx.doi.org/10.1016/j.jpba.2012.03.026
110. Kwok, K. and Taylor, L. S. (2012). Analysis of the Packaging Enclosing a Counterfeit Pharmaceutical Tablet using Raman Microscopy and Two-dimensional Correlation Spectroscopy. Vibrational Spectroscopy. 161:176-182. http://dx.doi.org/10.1016/j.vibspec.2012.02.018
109. Van Eerdenbrugh, B., Lo, M., Kjoller, K., Marcott, C. and Taylor, L.S. (2012) Nanoscale Mid-Infrared Imaging of Phase Separation in a Drug-Polymer Blend. Journal of Pharmaceutical Sciences. 101(6):2066-2073. http://dx.doi.org/10.1002/jps.23099
108. Li, N., Taylor, L. S. Ferruzzi, M. G. and Mauer, L. J. (2012) Kinetic study of catechin stability: Effects of pH,concentration, and temperature. Journal of Agricultural and Food Chemistry. 60(51)12531-12539. http://dx.doi.org/10.1021/jf304116s
107. Zhou, Q. Harris, M. T., and Taylor L. S. (2012) Modification of Crystallization Behavior in Drug/Polyethylene Glycol Solid Dispersions. Molecular Pharmaceutics. 9(3):546-553. http://dx.doi.org/10.1021/mp200546p
106. Alonzo, D.E., Raina, S., Zhou, D.,Gao, Y., Zhang, G.G.Z., and Taylor, L.S. (2012). Characterizing the Impact of Hydroxypropylmethyl Cellulose on the Growth and Nucleation Kinetics of Felodipine from Supersaturated Solutions. Crystal Growth and Design. 12(3):1538-1547. http://dx.doi.org/10.1021/cg201590j.
105. Van Eerdenbrugh, B. and Taylor, L. S. (2012) . Molecular Weight Effects on the Miscibility Behavior of Dextran and Maltodextrin with Poly(vinylpyrrolidone). Pharmaceutical Research. 29(10):2754-2765. http://dx.doi.org/10.1007/s11095-012-0689-5.
104. Weber, R. J. K., Benmore, C. J., Tumber, S. J., Tailor, A.N., Rey, C.A., Taylor, L. S. and Byrn, S. R. (2012) Acoustic Levitation: Recent Developments and Emerging Opportunities in Biomaterials Research. Eur. Biophys. J. 41(4):397-403. http://dx.doi.org/10.1007/s00249-011-0767-3
103. Baird, J. A. and Taylor, L.S. (2012) Evaluation of Amorphous Solid Dispersion Properties using Thermal Analytical Techniques. Advanced Drug Delivery Reviews. 64(5):396-421. http://dx.doi.org/10.1016/j.addr.2011.07.009
102. Trasi, N. S., Fanwick, P. E. and Taylor, L.S. (2012). Nilutamide. Acta Crystallographica E.68(3):o591. http://dx.doi.org/10.1107/S1600536812003728
101. Baird, J. A., Santiago-Quinonez, D., Rinaldi, C. and Taylor, L. S. (2012). Role of Viscosity in Influencing the Glass-forming Ability of Organic Molecules from the Undercooled Melt State. Pharm. Res. 29(1):271-284. http://dx.doi.org/10.1007/s11095-011-0540-4
100. Lipasek, R. A., Ortiz, J. C., Taylor, L. S. and Mauer, L. J. (2012) Effects of Anticaking Agents and Storage Conditions on the Moisture Sorption, Caking, and Flowability of Deliquescent Ingredients. Food Research International. 45(1):369-380. http://dx.doi.org/10.1016/j.foodres.2011.10.037
99. Rumondor, A.C.F, Wikström, H., Van Eerdenbrugh, B. and Taylor, L. S. (2011). Understanding the Tendency of Amorphous Solid Dispersions to Undergo Amorphous–Amorphous Phase Separation in the Presence of Absorbed Moisture. AAPSPharmSciTech. 12(4):1209-1219. http://dx.doi.org/10.1208/s12249-011-9686-y
98. Kestur, U.S., Van Eerdenbrugh, B. and Taylor, L.S. (2011) Influence of polymer chemistry on crystal growth inhibition of two chemically diverse organic molecules. CrystEngComm. 13:6712-6718 http://dx.doi.org/10.1039/c1ce05822c
97. Van Eerdenbrugh, B., and Taylor L. S. (2011). An Ab Initio Polymer Selection Methodology to Prevent Crystallization in Amorphous Solid Dispersions by Application of Crystal Engineering Principles. CrystEngComm. 13:6171-6178. http://dx.doi.org/10.1039/c1ce05183k
96. Lipasek, R. A., Taylor, L.S., and Mauer, L. J. (2011) Effects of Anticaking Agents and Relative Humidity on the Physical and Chemical Stability of Powdered Vitamin C. Journal of Food Science. 176(7):C1062-C1074 http://dx.doi.org/10.1111/j.1750-3841.2011.02333.x
95. Alonzo, D.E., Gao, Y.,Zhou, D., Mo, H., Zhang, G.G.Z., and Taylor, L.S. (2011) Dissolution and Precipitation Behavior of Amorphous Solid Dispersions. J. Pharm. Sci. 100(8):3316-3331. http://dx.doi.org/10.1002/jps.22579
94. Wanapun, D., Kestur, U. S., Kissick, D. J., Taylor, L. S., and Simpson, G. J. (2011) Single particle nonlinear optical imaging of trace crystallinity in an organic powder. Anal. Chem. 83(12):4745-4751. http://dx.doi.org/10.1021/ac1031397
93. Zhou, Q. Harris, M. T., and Taylor L. S. (2011) Time-resolved SAXS/WAXS study of the phase behavior and microstructural evolution of drug/PEG solid dispersions. Mol. Pharm. 8(3):932-939. http://dx.doi.org/10.1021/mp200041j
92. Baird, J. A. and Taylor, L. S. (2011) Evaluation and Modeling of the Eutectic Composition of Various Drug-Polyethylene Glycol Solid Dispersions. Pharmaceutical Development and Technology. 16(3):201-211 http://dx.doi.org/10.3109/10837450903584936
91. Van Eerdenbrugh, B., Alonzo, D. E. and Taylor L. S. (2011). Influence of particle size on the ultraviolet spectrum of particulate-containing solutions – implications for in-situ concentration monitoring using UV/Vis fiber-optic probes. Pharm. Res. 28(7):1643-1652. http://dx.doi.org/10.1007/s11095-011-0399-4
90. Sung,P-F., Hsieh Y-L., Angonese, K. Dunn, D., King, K., Machbitz, R., Christianson, A. Taylor, L. S., Harris, M. T., (2011) Complex Dielectric Properties of Microcrystalline Cellulose (MCC), Anhydrous Lactose and α-Lactose Monohydrate Powders Using a Microwave-Based Open Reflection Resonator Sensor. J. Pharm. Sci. 100(7):2920-2934 http://dx.doi.org/10.1002/jps.22516
89. Li, N., Taylor, L.S., and Mauer, L.J. (2011) Degradation kinetics of catechins in green tea powder: Effects of temperature and relative humidity. J. Agric. Food Chem. 59(11):6082-6090. http://dx.doi.org/10.1021/jf200203n
88. Van Eerdenbrugh, B., and Taylor L. S. (2011). Application of Mid-IR Spectroscopy for the Characterization of Pharmaceutical Systems. International Journal of Pharmaceutics. 417:3-16. http://dx.doi.org/10.1016/j.ijpharm.2010.12.011
87. Hiatt, A. N., Taylor, L. S. and Mauer, L. J. (2011). Effects of co-formulation of amorphous maltodextrin and deliquescent sodium ascorbate on moisture sorption and stability. International Journal of Food Properties. 14(4):726-740. http://dx.doi.org/10.1080/10942910903374114 .
86. Guerrieri, P., Zemlyanov, D., and Taylor, L.S. (2011) A study of water adsorption on organic crystal surfaces using a modified X-ray photoelectron spectroscopy instrument. Anal. Chem. 83(3):1144-1147. http://dx.doi.org/10.1021/ac102550e
85. Van Eerdenbrugh, B., Fanwick, P. E. and Taylor L. S. (2010).2-Butoxy-N-[2-(diethylamino)ethyl]-quinoline-4-carboxamide (dibucaine). Acta Crystallographica E. E66 o3189. http://dx.doi.org/10.1107/S1600536810045460
84. Kwok, K., Mauer, L. J. and Taylor, L.S. (2010) Kinetics of moisture-induced hydrolysis in powder blends stored at and below the deliquescence relative humidity: investigation of sucrose-citric acid mixtures. Journal of Agricultural and Food Chemistry. 58(22):11716-11724. http://dx.doi.org/10.1021/jf101941e
83. Van Eerdenbrugh, B., Fanwick, P. E. and Taylor L. S. (2010). 1-[(Biphenyl-4-yl)(phenyl)methyl]-1H-imidazole (bifonazole). Acta Crystallographica Section E. E66 o2649. http://dx.doi.org/10.1107/S1600536810037876
82. Van Eerdenbrugh, B., Fanwick, P. E. and Taylor L. S. (2010). 2-(Biphenyl-4-yl)acetic acid (felbinac). Acta Crystallographica E. E66 o2609. http://dx.doi.org/10.1107/S1600536810035828
81. Rumondor, A.C.F. and Taylor, L.S. (2010) Application of Partial Least Squares (PLS) Modeling in Quantifying Drug Crystallinity in Amorphous Solid Dispersions. International Journal of Pharmaceutics.398(1-2):155-160. http://dx.doi.org/10.1016/j.ijpharm.2010.07.049
80. Guerrieri, P., Rumondor, A.C.F., Li, T, and Taylor, L.S. (2010). Analysis of relationships between solid-state properties, counterion and developability of pharmaceutical salts. AAPS PharmSciTech. 11(3) 1212-1222. http://dx.doi.org/10.1208/s12249-010-9499-4
79. Zhou, Q., Taylor L. S. and Harris, M. T. (2010) Evaluation of the Microstructure of Semicrystalline Solid Dispersions. Molecular Pharmaceutics. 7(4):1291-1337. http://dx.doi.org/10.1021/mp1000907
78. Van Eerdenbrugh, B., and Taylor L. S. (2010). Small Scale Screening to determine the Ability of Different Polymers to Inhibit Drug Crystallization upon Rapid Solvent Evaporation. Molecular Pharmaceutics. 7(4):1328-1337. http://dx.doi.org/10.1021/mp1001153
77. Kestur, U. S., Lee, H., Santiago, D., Rinaldi, C., Won, Y-Y. and Taylor, L. S. (2010) Effects of the Molecular Weight and Concentration of Polymer Additives, and Temperature on the Melt Crystallization Kinetics of a Small Drug Molecule. Crystal Growth and Design. 10(8):3585-3596. http://dx.doi.org/10.1021/cg1004853
76. Kwok, K., Mauer, L. J. and Taylor, L.S. (2010) Phase Behavior and Moisture Sorption Behavior of Deliquescent Powders. Chemical Engineering Science. 65:5639-5650 http://dx.doi.org/10.1016/j.ces.2010.06.012.
75. Guerrieri, P., Zemlyanov, D., and Taylor, L.S. (2010) Dissociation of Water on the Surface of Organic Salts studied by X-ray Photoelectron Spectroscopy. Langmuir. 26(14): 11998-12002 http://dx.doi.org/10.1021/la101501p
74. Wanapun, D., Kestur, U. S., Kissick, D. J.,Simpson, G. J., and Taylor, L. S. (2010) Selective Detection and Quantitation of Organic Molecule Crystallization by Second Harmonic Generation Microscopy. Analytical Chemistry. 82(13): 5425-5432. http://dx.doi.org/10.1021/ac100564f
73. Van Eerdenbrugh, B., Baird, J. A. and Taylor, L. S. (2010). Crystallization tendency of active pharmaceutical ingredients following rapid solvent evaporation – classification and comparison with crystallization tendency from undercooled melts. Journal of Pharmaceutical Sciences. 99(9):3826-3838. http://dx.doi.org/10.1002/jps.22214
72. Baird, J. A., Van Eerdenbrugh, B and Taylor, L. S. (2010). A Classification System to Assess the Crystallization Tendency of Organic Molecules from Undercooled Melts. Journal of Pharmaceutical Sciences. 99(9):3787-3806. http://dx.doi.org/10.1002/jps.22197
71. Kestur, U.S. and Taylor, L.S. (2010). Role of Polymer Chemistry in Influencing Crystal Growth Rates from Amorphous Felodipine. CrystEngComm. 12:2390-2397. http://dx.doi.org/10.1039/c001905d
70. Hiatt, A. N., Ferruzzi, M. G., Taylor, L. S. and Mauer, L. J. (2011) Deliquescence behavior and chemical stability of vitamin C forms (ascorbic acid, sodium ascorbate, and calcium ascorbate) and blends. International Journal of Food Properties. 14(6):1330-1348 http://dx.doi.org/10.1080/10942911003650338
69. Hiatt, A. N., Taylor, L. S. and Mauer, L. J. (2010) Influence of simultaneous variations in temperature and relative humidity on chemical degradation of two vitamin C forms and implications for shelf-life models. Journal of Agricultural and Food Chemistry 58(6):3532-3540. http://dx.doi.org/10.1021/jf903342f
68. Rumondor, A.C.F. and Taylor, L.S. (2010) Effect of Polymer Hygroscopicity on the Phase Behavior of Amorphous Solid Dispersions in the Presence of Moisture. Molecular Pharmaceutics. 7(2):477-490. http://dx.doi.org/10.1021/mp9002283
67. Alonzo, D.E., Zhang, G.G.Z., Zhou, D., Gao, Y., and Taylor, L.S. Understanding the Behaviour of Amorphous Pharmaceutical Systems During Dissolution. Pharmaceutical Research 27(4):608-618. http://dx.doi.org/10.1007/s11095-009-0021-1
66. Rumondor, A.C.F., Konno, H., Marsac, P.J., and Taylor, L. S. (2010) Analysis of the Moisture Sorption Behavior of Amorphous Drug-Polymer Blends. Journal of Applied Polymer Science 117(2):1055-1063. http://dx.doi.org/10.1002/app.31803 .
65. Mauer L. J. and Taylor, L. S. (2010). Water-Solids Interactions: Deliquescence. Annual Review of Food Science and Technology. 1:41-63. http://dx.doi.org/10.1146/annurev.food.080708.100915
64. Guerrieri, P., Jarring, K., and Taylor, L.S. (2010) Impact of Counterion on the Chemical Stability of Crystalline Salts of Procaine. J. Pharm. Sci. 99(9):3719-3730. http://dx.doi.org/10.1002/jps.22009
63. Rumondor, A.C.F., Jackson, M.J. and Taylor, L.S. (2010) Effects of Moisture on the Growth Rate of Felodipine Crystals in the Presence and Absence of Polymers. Crystal Growth and Design. 10(2):747-753. http://dx.doi.org/10.1021/cg901157w
62. Mauer L. J. and Taylor, L. S. (2010). Deliquescence of Pharmaceutical Systems. Pharmaceutical Development and Technology. 15(6):582-594. http://dx.doi.org/10.3109/10837450903397594
61. Marsac, P.J., Rumondor, A.C.F., Nivens, D. E., Kestur, U. S.; Stanciu, L. and Taylor, L. S. (2010) Effect of Temperature and Moisture on the Miscibility of Amorphous Dispersions of Felodipine and Poly(vinyl pyrrolidone). Journal of Pharmaceutical Sciences. 99(1):169-185 http://dx.doi.org/10.1002/jps.21809.
60. Baird, J., Olayo-Valles, R., Rinaldi, C. and Taylor, L. S. (2010) Effect of Molecular Weight, Temperature, and Additives on the Moisture Sorption Properties of Polyethylene Glycol.Journal of Pharmaceutical Sciences. 99(1):154-168 http://dx.doi.org/10.1002/jps.21808.
59. Rumondor, A.C.F., Stanford, L. A. and Taylor, L.S. (2009) Effect of Polymer Type and Storage Relative Humidity on the Kinetics of Felodipine Crystallization from Amorphous Solid Dispersions. Pharm. Res. 26 (12):2599-2606. http://dx.doi.org/10.1007/s11095-009-9974-3
58. Rumondor, A.C.F., Ivanisevic, I., Bates, S., Alonzo, D. E. and Taylor, L. S. (2009) Evaluation of Drug-Polymer Miscibility in Amorphous Solid Dispersion Systems. Pharm. Res. 26 (11):2523-2534. http://dx.doi.org/10.1007/s11095-009-9970-7
57. Rumondor, A.C.F., Marsac, P.J., Stanford, L. A., and Taylor, L. S. (2009) Phase Behavior of Poly(vinylpyrrolidone) Containing Amorphous Solid Dispersions in the Presence of Moisture. Molecular Pharmaceutics. 6 (5):1492-1505. http://dx.doi.org/10.1021/mp900050c
56. Guerrieri, P., and Taylor, L.S. (2009) Role of salt and excipient properties on disproportionation in the solid-state. Pharmaceutical Research 26(8):2015-2026. http://dx.doi.org/10.1007/s11095-009-9918-y
55. Ortiz, J., Kestur U., Taylor, L.S. and Mauer, L.J. (2009) Interaction of environmental moisture with powdered green tea formulations: Relationship between catechin stability and moisture-induced phase transformations. Journal of Agricultural and Food Chemistry. 57(11):4691-4697.http://dx.doi.org/10.1021/jf8038583
54. Gift, A.D., Luner, P.E., Luedeman, L., and Taylor, L.S. (2009). Manipulating hydrate formation during high shear wet granulation using polymeric excipients. Journal of Pharmaceutical Sciences. 98(12):4670-4683. http://dx.doi.org/10.1002/jps.21763
53. Wikström, H., Kakidas, C. and Taylor, L.S. (2009). Determination of hydrate transition temperature using transformation kinetics obtained using Raman spectroscopy. Journal of Pharmaceutical and Biomedical Analysis. 49:247-252. http://dx.doi.org/10.1016/j.jpba.2008.11.008
52. Marsac, P.J., Li, T., and Taylor, L. S. (2009) Estimation of Drug-Polymer Miscibility and Solubility in Amorphous Solid Dispersions using Experimentally Determined Interaction Parameters. Pharmaceutical Research. 26(1):139-151. http://dx.doi.org/10.1007/s11095-008-9721-1
51. Konno, H., Handa, T., Alonzo, D. E. and Taylor, L. S. (2008). Effect of Polymer Type on the Dissolution Profile of Amorphous Solid Dispersions Containing Felodipine. European Journal of Pharmaceutics and Biopharmaceutics. 70:493-499. http://dx.doi.org/10.1016/j.ejpb.2008.05.023
50. Hiatt, A.N. Ferruzzi, M., Taylor, L.S., and Mauer, L. J. (2008) Impact of deliquescence on the chemical stability of vitamins B1, B6, and C in powder blends. Journal of Agricultural and Food Chemistry. 56 (15): 6471–6479. http://dx.doi.org/10.1021/jf800709f
49. Towler C. S., Li, T. Wikström, H, Remmick, D., Sanchez-Felix M. V. and Taylor, L. S. (2008) An investigation into the influence of counter-ion on the properties of some amorphous organic salts. Molecular Pharmaceutics. 5 (6): 946-955. http://dx.doi.org/10.1021/mp8000342
48. Wikström, H.; Rantanen, J.; Gift, A. D. and Taylor, L. S. (2008) Towards an understanding of the factors influencing anhydrate-to-hydrate transformation kinetics in aqueous environments. Crystal Growth and Design. 8 (8): 2684–2693. http://dx.doi.org/10.1021/cg070629e
47. Ortiz, J., Ferruzzi, M., Taylor, L.S. and Mauer, L.J. (2008) Interaction of Environmental Moisture with Powdered Green Tea Formulations: Effect on Catechin Chemical Stability. Journal of Agricultural and Food Chemistry 56:4068-4077. http://dx.doi.org/10.1021/jf800246s
46. Gift, A.D., Luner, P.E., Luedeman, L., and Taylor, L.S. (2008) Influence of Polymeric Excipients on Crystal Hydrate Formation Kinetics in Aqueous Slurries. Journal of Pharmaceutical Sciences 97:5198-5211. http://dx.doi.org/10.1002/jps.21379
45. Marsac, P.J., Romary, D.P., Shamblin, S.L., Baird, J.A., and Taylor, L.S. (2008) Spontaneous Crystallinity Loss of Drugs in the Disordered Regions of Poly(ethylene oxide) in the Presence of Water. Journal of Pharmaceutical Sciences. 97: 3182-3194. http://dx.doi.org/10.1002/jps.21237
44. Guerrieri, P., Smith, D.T., and Taylor, L.S. (2008) Phase Behavior of Ranitidine HCl in the Presence of Atmospheric Moisture and Degradants – Influence on Chemical Reactivity. Langmuir 24:3850-3856. http://dx.doi.org/10.1021/la703031c
43. Wikström, H., Carroll, W.J., and Taylor, L.S. (2008) Manipulating theophylline hydrate formation during high shear wet granulation through improved understanding of the role of pharmaceutical excipients. Pharmaceutical Research.25(4):923-978. http://dx.doi.org/10.1007/s11095-007-9450-x
42. Konno, H., and Taylor, L.S. (2008) Ability of Different Polymers to Inhibit the Crystallization of Amorphous Felodipine in the Presence of Moisture. Pharmaceutical Research 25(4): 969-978. http://dx.doi.org/10.1007/s11095-007-9331-3
41. Marsac, P.J., Konno, H., Rumondor, A.C.F., and Taylor, L.S. (2008) Recrystallization of Nifedipine and Felodipine from Amorphous Molecular Level Solid Dispersions Containing Poly(vinylpyrrolidone) and Sorbed Water. Pharmaceutical Research 25 (3):647-656. http://dx.doi.org/10.1007/s11095-007-9420-3
40. Hu, Y., Wikström, H., Byrn, S.R., and Taylor, L.S. (2007) Estimation of the Transition Temperature for an Enantiotropic Polymorphic System from the Transformation Kinetics Monitored using Raman Spectroscopy. Journal of Pharmaceutical and Biomedical Analysis 45:546–551. http://dx.doi.org/10.1016/j.jpba.2007.07.028
39. Romero-Torres, S., Wikström, H., Grant, E.R., and Taylor L.S. (2007) Monitoring of Mannitol Phase Behavior during Freeze-Drying Using Non-Invasive Raman Spectroscopy. PDA Journal of Pharmaceutical Science and Technology 61(2):131-145.
38. Towler, C.S., and Taylor, L.S. (2007) Spectroscopic Characterization of Inter-Molecular Interactions in Solution and Their Influence on Crystallization Outcome. Crystal Growth and Design 7(4):633-638. http://dx.doi.org/10.1021/cg0602358
37. Gift, A.D., and Taylor, L.S. (2007) Hyphenation of Raman Spectroscopy with Gravimetric Analysis to Interrogate Water-Solid Interactions in Pharmaceutical Systems. Journal of Pharmaceutical and Biomedical Analysis 43:14-23. http://dx.doi.org/10.1016/j.jpba.2006.06.025
36. Guerrieri P., Salameh A.K., and Taylor, L.S. (2007) Effect of Small Levels of Impurities on the Moisture Sorption Behavior of Ranitidine HCl. Pharmaceutical Research 24(1):147-156. http://dx.doi.org/10.1007/s11095-006-9134-y
35. Salameh, A.K., and Taylor, L.S. (2006) Deliquescence Induced Caking in Binary Powder Blends. Pharmaceutical Development and Technology 11:453-464. http://dx.doi.org/10.1080/10837450600939057
34. Konno, H., and Taylor, L.S. (2006) Influence of Different Polymers on the Crystallization Tendency of Molecularly Dispersed Amorphous Felodipine. Journal of Pharmaceutical Sciences 95(12):2692-2705. http://dx.doi.org/10.1002/jps.20697
33. Marsac, P.J., Shamblin, S.L., and Taylor, L.S. (2006) Theoretical and Practical Approaches for Prediction of Drug-Polymer Miscibility and Solubility. Pharmaceutical Research 23(10):2417-2425. http://dx.doi.org/10.1007/s11095-006-9063-9
32. Marsac, P.J., Konno, H., and Taylor, L.S. (2006) A Comparison of the Physical Stability of Amorphous Felodipine and Nifedipine Systems. Pharmaceutical Research 23(10):2306-2316. http://dx.doi.org/10.1007/s11095-006-9047-9
31. Hu, Y., Wikström, H., Byrn S.R., and Taylor, L.S. (2006) Analysis of the Effect of Particle Size on Polymorphic Quantitation by Raman Spectroscopy. Applied Spectroscopy 60(9):977-984. http://dx.doi.org/10.1366/000370206778397272
30. Wikström, H., Romero-Torres, S., Wongweragiat, S., Stuart Williams, J.A., Grant, E.R., and Taylor, L.S. (2006) On-Line Content Uniformity Determination of Tablets Using Low-Resolution Raman Spectroscopy. Applied Spectroscopy 60(6):672-681. http://dx.doi.org/10.1366/000370206777670684
29. Salameh, A.K., and Taylor, L.S. (2006) The Role of Deliquescence Lowering in Enhancing Chemical Reactivity in Physical Mixtures. Journal of Physical Chemistry B 110(20):10190-10196. http://dx.doi.org/10.1021/jp0612376
28. Salameh, A.K., Mauer L.J., and Taylor, L.S. (2006) Deliquescence Lowering in Food Ingredient Mixtures. Journal of Food Science 71(1):E10-E16
27. Salameh, A.K., and Taylor, L.S. (2006) Physical Stability of Crystal Hydrates and Their Anhydrates in the Presence of Excipients. Journal of Pharmaceutical Sciences 95(2):446-461. http://dx.doi.org/10.1002/jps.20532
26. Rantanen, J., Wikström, H., Rhea, F.E., and Taylor, L.S. (2005) Improved Understanding of Factors Contributing to Quantification of Anhydrate/Hydrate Powder Mixtures. Applied Spectroscopy 59(7):942-951. http://dx.doi.org/10.1366/0003702054411670
25. Wikström, H., Lewis, I.R., and Taylor, L.S. (2005) Comparison of Sampling Techniques for In-Line Monitoring Using Raman Spectroscopy. Applied Spectroscopy 59(7):934-941. http://dx.doi.org/10.1002/jps.20241
24. Salameh, A.K., and Taylor, L.S. (2005) Deliquescence in Binary Mixtures. Pharmaceutical Research 22(2):318-324. http://dx.doi.org/10.1007/s11095-005-1563-5
23. Rantanen, J., Wikström, H., Turner, R., and Taylor, L.S. (2005) Use of In-Line Near- Infrared Spectroscopy in Combination with Chemometrics for Improved Understanding of Pharmaceutical Processes. Analytical Chemistry 77(2):556-563. http://dx.doi.org/10.1021/ac048842u
22. Hu, Y., Liang, J., Myerson, A., and Taylor, L.S. (2005) Crystallization Monitoring by Raman Spectroscopy: Simultaneous Measurement of Desupersaturation Profile and Polymorphic Form in Flufenamic Acid Systems. Industrial and Engineering Chemistry Research 44(5):1233-1240. http://dx.doi.org/10.1021/ie049745u
21. Wikström, H., Marsac, P.J., and Taylor, L.S. (2005) In-Line Monitoring of Hydrate Formation During Wet Granulation Using Raman Spectroscopy. Journal of Pharmaceutical Sciences 94(1):209-219. http://dx.doi.org/10.1002/jps.20241
20. Ringqvist, A., Taylor, L.S.,Ekelund, K., Ragnarsson, G., Engströme, S., and Axelsson, A. (2003) Atomic Force Microscopy Analysis and Confocal Raman Microimaging of Coated Pellets. International Journal of Pharmaceutics 267(1-2):35 47. http://dx.doi.org/10.1016/j.ijpharm.2003.07.004
19. Santesson, S., Johansson, J., Taylor, L.S., Levander, I., Fox, S., Sepaniak, M., and Nilsson, S. (2003) Airborne Chemistry Coupled with Raman Spectroscopy. Analytical Chemistry 75(9):2177-2180. http://dx.doi.org/10.1021/ac026302w
18. Johansson, J., Pettersson, S. and Taylor, L.S. (2002) Infrared Imaging of Laser-Induced Heating During Raman Spectroscopy of Pharmaceuticals. Journal of Pharmaceutical and Biomedical Analysis 30:1223-1231. http://dx.doi.org/10.1016/S0731-7085(02)00461-2
17. Ahlqvist, M.U.A., and Taylor, L.S. (2002) Water Dynamics in Channel Hydrates Investigated Using H/D Exchange. International Journal of Pharmaceutics 241(2):253-261. http://dx.doi.org/10.1016/S0378-5173(02)00242-9
16. Tong, P., Taylor, L.S., and Zografi, G. (2002) Influence of Alkali Metal Counterions on the Glass Transition Temperature of Amorphous Indomethacin Salts. Pharmaceutical Research 19(5):649-654. http://dx.doi.org/10.1023/A:1015310213887
15. Tang, X.C., Pikal, M.J., and Taylor, L.S. (2002) The Effect of Temperature on Hydrogen Bonding in Crystalline and Amorphous Phases in Dihydropyridine Calcium Channel Blockers. Pharmaceutical Research 19(4):484-490. http://dx.doi.org/10.1023/A:1015199713635
14. Tang, X.C., Pikal, M.J., and Taylor, L.S. (2002) A Spectroscopic Investigation of Hydrogen Bond Patterns in Crystalline and Amorphous Phases in Dihydropyridine Calcium Channel Blockers. Pharmaceutical Research 19(4):477-483. http://dx.doi.org/10.1023/A:1015147729564
13. Ahlqvist, M.U.A., and Taylor, L.S. (2002) Water Diffusion in Hydrated Crystalline and Amorphous Sugars Monitored Using H/D Exchange. Journal of Pharmaceutical Sciences 9(3):690-698. http://dx.doi.org/10.1002/jps.10068
12. Broman, E.; Khoo, C., and Taylor, L.S. (2001) A Comparison of Alternative Polymer Excipients and Processing Methods For Making Solid Dispersions of a Poorly Water Soluble Drug. International Journal of Pharmaceutics 222(1):139-151. http://dx.doi.org/10.1016/S0378-5173(01)00709-8
11. Taylor, L.S., and Langkilde F.W., and Zografi, G. (2001) Fourier Transform Raman Spectroscopic Study of the Interaction of Water Vapor with Amorphous Polymers. Journal of Pharmaceutical Sciences 90(7):888-901. http://dx.doi.org/10.1002/jps.1041
10. Taylor, L.S., and Langkilde F.W. (2000) Evaluation of Solid State Forms Present in Tablets by Raman Spectroscopy. Journal of Pharmaceutical Sciences 89(10):1342-1353. http://dx.doi.org/10.1002/1520-6017(200010)89:10<1342::AID-JPS12>3.0.CO;2-X
9. Taylor, L.S., and Zografi, G. (1998) Sugar-Polymer Hydrogen Bond Interactions in Lyophilised Amorphous Mixtures. Journal of Pharmaceutical Sciences 87(12):1615-1621. http://dx.doi.org/10.1021/js9800174
8. Shamblin, S.L., Taylor, L.S., and Zografi, G., and (1998) Mixing Behavior of Colyophilized Binary Systems. Journal of Pharmaceutical Sciences 87(6):694-701. http://dx.doi.org/10.1021/JS9704801
7. Taylor, L.S., and Zografi, G. (1998) The Quantitative Analysis of Crystallinity Using FT-Raman Spectroscopy. Pharmaceutical Research 15(5):755-761. http://dx.doi.org/10.1023/A:1011979221685
6. Taylor, L.S., and York, P. (1998) Effect of Particle Size and Temperature on the Dehydration Kinetics of Trehalose Dihydrate. International Journal of Pharmaceutics 167(1-2):215-221. http://dx.doi.org/10.1016/S0378-5173(98)00065-9
5. Taylor, L.S.; Williams, A.C.; and York, P. (1998) Particle Size Dependent Molecular Rearrangements During the Dehydration of Trehalose Dihydrate-In Situ FT-Raman Spectroscopy. Pharmaceutical Research 15(8):1207-1214. http://dx.doi.org/10.1023/A:011935723444
4. Taylor, L.S., and York, P. (1998) Characterization of the Phase Transitions of Trehalose Dihydrate on Heating and Subsequent Dehydration. Journal of Pharmaceutical Sciences 87(3):347-355. http://dx.doi.org/10.1021/js970239m
3. Taylor, L.S., and Zografi, G. (1997) Spectroscopic Characterization of Interactions between PVP and Indomethacin in Amorphous Molecular Dispersions. Pharmaceutical Research 14(12):1691-1698. http://dx.doi.org/10.1023/A:1012167410376
2. Taylor, L.S.; Williams, A.C.; and Mehta, V., and York, P. (1997) Characterization of Frozen Glucose Solutions. Pharmaceutical Development and Technology 2(4):395-402.
1. Taylor, L.S.; Williams, A.C.; Edwards, H.G.M.; Mehta, V.; Jackson, G.S.; Badcoe, I.G.; and Clarke, A., and York, P. (1995) Sucrose Reduces the Efficiency of Protein Denaturation by a Chaotropic Agent. Biochimica et Biophysica Acta 1253(1):39-46. http://dx.doi.org/10.1016/0167-4838(95)00142-H
Retrieved from "https://openwetware.org/mediawiki/index.php?title=Taylor:Publications&oldid=1087305"


Mission #79 October 17, 1944 44-8147 H/S 7BS Israelsen Major damage. BARCLAY (WG), severely WIA.
Mission #87 November 5, 1944 44-8237 H/I 7BS Israelson (PFF) Major damage.
Took off at 0515 hours from Hardstand #22.
Carried 12 500 lb bombs. Dropped short of the Primary at 0856 hours from 15,000 feet.
Bombs fell "just short of target. Low Squadron made direct hits, when they left 2 of the buildings were on fire."
Top turret hydraulic leak causing inoperation. Replaced.
Left solenoid in nose turret inoperative, ckecked and found OK.
Right solenoid in ball turret inoperative, checked and found OK.
Crew Status Report at 1700 hours.
Took off at 0835 hours.
Carried 10 500 lb GP bombs. Dropped on the Primary at 1357 hours from 21,600 feet.
#1 generator inoperative. Inspected and repaired.
Took off at 1020 hours from Hardstand #1.
Carried 10 500 lb GP bombs. Dropped on the Primary at 1501 hours from 22,000 feet.
Took off at 1146 hours on a bomb. flight.
2 Lt Thomas J Campbell, O-733529, is relieved from Crew #1, Israelsen, and assigned to Crew #5, Simpson.
2 Lt Seamons J Jones, O-695369, is relieved from Crew #5, Simpson, and assigned to Crew #1, Israelsen.
Took off at 0242 hours.
Flew Lead of 4th Squadron.
Israelsen, O. A. (P) Capt.
Burton, H. C. (Command Pilot) Col.
Bice, R. G., Jr. (CP) 2nd Lt.
Kleinfall, C. W. (N) 1st Lt.
Reed, J. R. (N) 1st Lt.
Jones, S. J. (B) 2nd Lt.
Took off at 1636 hours.
Flew as Lead on Lead Squadron.
Carried 12 500 lb GP bombs. Failed to bomb due to weather. Brought all bombs back.
Took off at 0514 hours.
Carried 24 250 lb bombs. Dropped 22 bombs on the Primary at 0910 hours from 23,000 feet. Jettisoned 2 bombs.
Took off at 1703 hours on Local flight.
Took off at 0445 hours.
Carried 12 500 lb bombs. Dropped on the Primary at 0915 hours from 23,000 feet.
Took off at 1458 hours from Hardstand #8.
Carried 46 100 lb bombs. Dropped on the Primary at 1918 hours from 19,500 feet.
Took off at 1633 hours on a local flight.
Took off at 0438 hours.
Carried 52 100 lb bombs. Dropped on the Primary at 0817 hours from 21,800 feet.
Took off at 0400 hours.
Carried 24 250 lb bombs. Brought all bombs back to base.
Recalled at 0710 hours while 15 miles NW of La Havre.
Took off at 1150 hours for a local flight.
Took off at 0525 hours.
Carried 20 250 lb bombs. Dropped on the Primary at 0910 hours from 24,000 feet.
Took off at 1341 hours on a flight to the practice range.
Took off at 1017 hours.
Flew Deputy Lead, position 1-2 in High Squadron, A Group.
Took off at 1313 hours on a local flight.
Took off at 1404 hours.
Took off at 1506 hours on a local flight.
Carried 5 1000 lb bombs. Dropped on the Primary at 1051 hours from 21,000 feet.
Took off at 1620 hours.
Was this a practice mission? Lead of a group of 11 planes.
Took off at 0725 hours.
Flew Deputy Lead, position 1-2 of Lead Squadron.
Carried 10 500 lb GP bombs. Dropped on the Primary at 1113 hours from 22,500 feet.
Took off at 0516 hours.
Flew Lead of High Squadron on 34BG.
Carried 6 1000 lb bombs. Dropped on the Secondary at 0900 hours from 21,600 feet.
C-1 needs flight check; "G" box should be replaced; replace dome on top turret. Inspected & repaired.
Carried 12 250 lb bombs. Brought all bombs back to base due to weather.
Gas leak in auxiliary tank; waist section heated suit rheostat inoperative. Inspected and repaired.
Landed at 1245 hours at Mendlesham.
Flight was a direct flight at 084 degrees, 11 miles.
Weather: Clouds 10/10 with base at 400 to 600 feet with tops at 30,000 feet with rain and drizzle.
Wind at 500 feet was from 010 degrees at 8-10 MPH.
Took off from Hardstand #9 at 0600 hours.
Flew Lead of 34 B Group.
Carried 24 260F bombs. Dropped on the Primary at 1000 hours from 21,500 feet.
Took off at 0705 hours from Hardstand #9.
T/Sgt Clarence J. Markham 6659639 (Radio Op) was lightly WIA and admitted Nov. 5, 1944 to the 65th General Hospital.
Plane was in 34th BG markings.


CALGARY - Calgary's mayor is again demanding answers from Canadian Pacific Railway after eight rail cars full of oil chemicals derailed at a train yard in the city, forcing the closure of major road and the evacuation of some homes.
Six of the cars, which were carrying a diluting agent used in oil pipelines, flipped over during rush hour Wednesday. Residents in some homes in the immediate area were told to leave, but no one was hurt and none of the cars leaked.
The derailment comes less than three months after a bridge over the swollen Bow River gave way underneath a CP train (TSX:CP) while the city was trying to recover from severe flooding.
Mayor Naheed Nenshi said "two derailments is two too many."
Nenshi was one of the Calgarians trapped in traffic during Wednesday's derailment.
"That is not only massively inconvenient for people, it's also massively dangerous as we have thousands and thousands of people going through this area," Nenshi said Thursday.
"Once again it was city staff, who have no regulatory authority on this, risking their lives to solve the problem and we can't solve the problem if we're not given correct, accurate information at the beginning.
"It again highlights what municipal politicians have been saying for a very long time, which is we need better regulations on the movement of trains through cities and particularly the time of those movements."
Nenshi was furious when the derailment happened during the flood recovery, questioning whether the company had laid off any of its bridge inspectors. The tank cars involved then were also carrying a petroleum dilutant. They were unloaded and removed without going into the river.
Engineers blamed the failure of the bridge on fast water scouring away gravel under a support.
CP CEO Hunter Harrison said at the time that the company would have normally sent divers down to inspect the bridge, but the water was moving too fast and it would have been "jeopardizing commerce" to hold back trains.
Nenshi said the cause of the latest derailment still isn't clear.
"I'd really like to know what actually happened. How in the world did these rail cars tip over?" he asked.
"Again we had an enormous amount of trouble getting a straight answer from CP about what was in those cars. As a matter of fact one of my colleagues got a phone call from CP where they said, 'you throw a match in there it won't catch fire.' Well, given that it was natural gasoline, that's not quite true."
Nenshi had a long conversation with Harrison after the June derailment in which he received an apology. He intends to renew their relationship in the near future.
"We had a very good conversation around the derailment in which I was assured safety was the primary concern of Canadian Pacific, that they hadn't laid off any people who were focused on safety or inspection of track," Nenshi said.
"I want to have a good conversation about understanding what's being shipped, how it's being shipped, how we communicate and what CP is willing to do to make sure danger to others is minimized."
CP spokesman Ed Greenberg said a meeting with Nenshi is planned in the coming days.
"We value our relationship with the City of Calgary and the mayor," Greenberg said. "We look forward to having a dialogue and an exchange of information with Mayor Nenshi."


Burgers have and always will be one of my favorite food items… and when I started doing more food photography for work, I found myself cooking less and out to eat more. Luckily, I've been fortunate enough to have some pretty damn good burgers — and plenty of photos of them. Here are a few.


text:
Prejudice, Real and Invented
First, the news item, from B. Daniel Blatt aka GayPatriotWest:
The news division of another broadcast network has been staging "news" in an attempt to show the prejudices of the American people. Only this time, it didn't work out as planned. After planting a gay couple and an actor portraying a loud-mouthed anti-gay bigot at a New Jersey sports bar, ABC News learned that the bar's patrons are, on the whole, a remarkably tolerant lot.
Surprise, surprise. You might be reminded, as Dan was, of this incident from three years ago:
Date: Mon, 27 Mar 2006 13:05:54 -0800 (PST)
Subject: Looking for Muslim Males to participate in NBC Dateline Segment
[Forwarded]
I hope everyone is doing well.
I have been talking with a producer of the NBC Dateline show and he is in the process of filming a piece on anti-Muslim and anti-Arab discrimination in the USA. They are looking for some Muslim male candidates for their show who would be willing to go to non-Muslim gatherings and see if they attract any discriminatory comments or actions while being filmed. ...
That said, I'm urgently looking for someone who can be filmed this April 1st weekend at a Nascar event (and other smaller events) in Virginia. NBC is willing to fly in someone and cover their weekend expenses. The filming would take place all day on Saturday and Sunday.
I'll let the good folks at NASCAR have the last word on that one:
The inference is that NASCAR fans are bigots, and NBC News was hoping to bait fans into making insensitive remarks to the Muslim / Arab people it had planted at the track.
Ramsey Poston, NASCAR's managing director of corporate communications, said Wednesday that no instances of unrest were reported. "No one bothered them," Poston said.
It's hard to imagine that NBC News would try to entrap fans in a ploy to make its Dateline segment juicier. But apparently the network did just that; NBC did not deny its actions when confronted by NASCAR.
So, back to ABC's stunt:
When, however, they dispatched an actor to verbally harass a gay couple they had sent to a New Jersey sports bar, they found more tolerance than bigotry. While a handful of patrons expressed disapproval of the couple's presence in the bar, the patrons who spoke out the loudest called the actor on his bigotry, in the process challenging the prejudices the ABC News producers apparently harbored against the patrons of a suburban sports bar.
They had the gay couple come into the bar at two different times — first during the mid-day lunch hour, then later in the evening.
In the mid-day visit, no one took much notice of the two men until the aforementioned actor, at the network's behest, started "stirring the pot," pretending "to be bothered" by the couple. A few guys seemed to share his sentiments but didn't act out their animosity.
Yet when the actor pestered a "new arrival" about the gay guys, the new guy did express some animus, though not against the gay couple. He told the ostensibly bigoted actor to shut up, saying that if he had to choose between that irritated individual and the gay couple, he'd probably be asking him, not them, to leave. Indeed, he told the gay men, "I'd rather have twelve of you them than four of him."
In the evening, the couple turned up the heat by increasing their public displays of affection. At the same time, the producers raised the stakes by having a straight couple, also actors, "appear to be bothered too." The actor remained obnoxious. A few people grumbled, with one man saying the gay men's display "disgusts" him. But the most agitated person was a woman who objected not to the their affection, but to the basher's antics.
Go to the article to read the rest, but this comment from Dan caught my eye: "The only gay bashing that took place at this sports bar was a verbal one staged by ABC."
And that put me in mind of an incident (or series of incidents) in Canada mentioned by Ezra Levant (and cited by Five Feet of Fury):
Who is Canada's largest "hate group", as measured by the number of anti-Semitic, anti-gay, anti-black and pro-Nazi comments published on the Internet?
As I've pointed out before, it's none other than the taxpayers' own Canadian Human Rights Commission.
It is official CHRC policy for their employees to join neo-Nazi groups, and go online in full neo-Nazi drag, spewing filthy venom that would make Joseph Goebbels proud. ...
It's as if liberals have found they haven't got enough real bigots to keep them busy these days, and must invent them, or else lose their own relevance.
Because it's either that, or else be forced to take on the real bigots. And that's dangerous work.
Ledeen on Victory
Michael Ledeen has an excellent piece on President Obama's AfPak strategy. I'll just excerpt this snippet on the Israel/Egypt war and peace:
A few days before his Afpak speech, the president celebrated the 30th anniversary of the Israel/Egypt peace agreement. "As we commemorate this historic event, we recall that peace is always possible even in the face of seemingly intractable conflicts," he said. And then, referring to his own intentions, he continued:
The success…demonstrated that progress results from sustained efforts at communication and cooperation…we honor the courage and foresight of these leaders…as we seek to expand the circle of peace among Arabs and Israelis, we take inspiration from what Israel and Egypt achieved three decades ago, knowing that the destination is worthy of the struggle.
But that's not how it happened. Not at all.
First, Egypt was decisively defeated by Israel on the battlefield, convincing Anwar Sadat that there was no possibility of wiping out Israel, and that any attempt to do it would be disastrous for his country. Second, both the United States and the Soviet Union started designing a "peace" deal, and Sadat didn't like the prospect of a renewed Soviet role in the region. He was even prepared to talk directly to the Israelis. So he went to Jerusalem.
Thus, contrary to Obama's reconstruction of events in the 1970s, the peace treaty between Egypt and Israel was the result of an Israeli victory on the battlefield. ...
Go read the whole thing.
Stop Iran
The Spirit of Man:
I doubt Obamble would stop the crazy Mullahs from acquiring the atomic weapon but apparently some tough guy in Israel will go the extra mile to stop these crazies in Tehran:
"You don't want a messianic apocalyptic cult controlling atomic bombs. When the wide-eyed believer gets hold of the reins of power and the weapons of mass death, then the entire world should start worrying, and that is what is happening in Iran."
Of course the Obama administration lacks the balls to stop anything, let alone the determined Iranian regime.
Netanyahu to Obama: Stop Iran, or I will.
In an interview conducted shortly before he was sworn in today as prime minister of Israel, Benjamin Netanyahu laid down a challenge for Barack Obama. The American president, he said, must stop Iran from acquiring nuclear weapons—and quickly—or an imperiled Israel may be forced to attack Iran's nuclear facilities itself.
"The Obama presidency has two great missions: fixing the economy, and preventing Iran from gaining nuclear weapons," Netanyahu told me. He said the Iranian nuclear challenge represents a "hinge of history" and added that "Western civilization" will have failed if Iran is allowed to develop nuclear weapons. ...
Arutz Sheva: Israeli covert ops draw Washington disapproval.
Israel plans to continue a covert operation to delay Iran's nuclear program by assassinating key Iranian scientists despite growing opposition from the United States, U.S. officials said. Active for almost a decade, the program involves targeted killings of key Iranian assets as well as disrupting and sabotaging Iran's nuclear technology purchasing network abroad, the sources said.
U.S. opposition to the program has intensified as President Barack Obama makes overtures aimed at relieving tensions between the two countries, partly due to the U.S.'s desire to use Iran's road networks into Afghanistan to help resupply U.S.-NATO forces there. ...

redpajama_set_name: RedPajamaCommonCrawl