text:
Justice for Kentex Workers! Ensure criminal prosecution of Kentex factory owners! Discharge from post Sec. Baldoz, Roxas, top officials of DOLE, DILG and BFP! Just compensation to Kentex fire victims and workers! Pass Workers SHIELD Bill!
Justice4KentexWorkers Alliance started this petition to President , Republic of the Philippines President Benigno Aquino III
Justice for Kentex Workers!
A seven-hour blaze gutted the factory of Kentex Manufacturing Inc., maker of rubber sandals that are popular in the Philippines, last May 13, 2015 at Tatalon Street, Barangay Ugong, Valenzuela City. This is the deadliest industrial fire in the history of the Philippines: more than72 workers perished, several others are still missing, and over a hundred more lost their jobs.
The fact-finding mission conducted by labor groups in the Philippines a day after the Kentex tragedy revealed the company's serious violations of occupational health and safety (OHS) standards. These include the following: mishandling of highly flammable chemicals shown by absence of proper storage and labeling of the latter; absence of fire exits at the second floor; absence of fire alarms and drills; and, with the thick steel mesh that covered the factory's windows, the virtual imprisonment of workers.
Apart from grave violations of OHS standards, massive violations of basic labor standards by the company were also exposed. The workers who have worked for the company for more than 10 years were receiving only the legally-mandated minimum wage rate. Workers were deprived of regular status even if they have worked in the company for many years. The agency which supplies manpower to Kentex, CJC Manpower Services, repeatedly rehired workers as contractuals and paid the latter a mere P202 a day, way below the P481 minimum wage rate in the National Capital Region. Kentex also employed the piece-rate wage scheme, which is against the law. CJC Manpower Services also failed to remit workers' contributions to the Social Security System and PhilHealth despite regularly deducting these from the salaries of workers.
The Bureau of Fire Protection (BFP) did not issue Kentex a Fire Safety Inspection Certificate (FSIC) after conducting an inspection last July 2014 but apparently failed to give appropriate reports to the local government for subsequent action and failed to monitor the factory's continued operation. Following an inspection on September 18, 2014 the Department of Labor and Employment (DOLE), by virtue of Department Order (DO) 131-13 or the "Rules on Labor Laws Compliance System" promulgated by Sec. Rosalinda Baldoz, issued Kentex a Certificate of Compliance (COC) with regard to General Labor Standards (GLS) and Occupational Safety and Health (OHS) Standards .
The Kentex tragedy, alongside numerous workplace accidents that claimed the lives of many workers, highlights the abysmal situation of Filipino workers despite the Aquino government's claim that the country is experiencing economic growth. All of these are brought about by (a) capitalists' drive to cut costs that compliance with OHS standards entail in order toincrease profits and (2) the government's implementation of neoliberal labor policies that perpetuate a system that allows hazardous workplaces to exist and create a culture of impunity for past, present and future worker deaths.
Our demands and fight for justice
We support the families of victims of the Kentex fire and the workers who survived the fire, the labor groups, church groups and people's organizations – all who have come together under the Justice for Kentex Workers Alliance to demand justice for those who died and those who survived.
In particular we call on President Benigno Simeon Aquino III to:
1)Ensure the criminal prosecution of the owners of Kentex Manufacturing Inc. We demand criminal liability from the company owners who, in their desire to increase profits, willfully ignored workers' health and safety standards, and laid out the conditions that resulted in the death of our loved ones.
2) Immediately discharge from their posts and to ensure criminal prosecution of Department of Labor and Employment (DOLE) Sec. Rosalinda Baldoz and top officials of the DOLE and Department of Interior and Local Government (DILG) Sec. Mar Roxas and top officials of the Bureau of Fire Protection (BFP) who condoned the operation of a factory that proved to be fatal to workers.
The connivance of these officials with the capitalists of Kentex sealed the fate of the workers who were killed in the fire. DOLE's awarding of a COC to Kentex was tantamount to signing the death certificates of the workers who died. They are liable not only for the lives claimed and affected by the Kentex fire, but for all Filipino workers whose lives are imperiled as a result of DOLE's policies like Department Order (DO) 131-13, which systematizes and legalizes industry self-regulation (instead of strict compliance) to the detriment of workers' rights and in favor of capitalists' business interests.
(3) Ensure just compensation for the families and survivors of the Kentex factory fire.
We are also fighting for just compensation for the victims' families and the survivors. It is only fair that that receive more than the meager compensation mandated by the country's laws. The said compensation should in fact be increased because Kentex workers were given wages below the legally-mandated minimum and suffered many injustices while working, and working hard, for the company.
(4) Urgent passage of House Bill 4635 or Workers' SHIELD, sponsored by Gabriela Women's Partylist which seeks to institutionalize mandatory government inspections of all workplaces, and appropriately penalize violators of basic standards. The Kentex fire highlights the extreme vulnerability of Filipino workers because of the government's skewed priorities favoring business over labor, and the passage of HB 4635 would be a major step forward towards the reaffirmation of the sanctity of workers' lives.
Justice for Kentex Workers Alliance is composed of families of victims and worker-survivors of the Kentex factory fire as well as the following support organizations: Institute for Occupational Health and Safety Standard (IOHSAD), Center for Trade Union and Human Rights (CTUHR), Church-People Worker Solidarity (CWS) Defend Jobs Philippines, Ecumenical Institute for Labor Education and Research (EILER), Gabriela, Kilusang Mayo Uno (KMU).
President Aquino: Ensure Criminal Prosecution of Owners of Kentex, Top gov't Officials Responsible for the Kentex factory fire!
Today: Justice4KentexWorkers is counting on you
Justice4KentexWorkers Alliance needs your help with "President Aquino: Ensure Criminal Prosecution of Owners of Kentex, Top gov't Officials Responsible for the Kentex factory fire!". Join Justice4KentexWorkers and 3,906 supporters today.


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The Explorer Club is brand new to WHS but already has over 50 members. Our mission is to explore and appreciate the Arizona outdoors through hiking while learning about biodiversity, wilderness survival and conservation. Our last trip was to the town of Cave Creek. We were fortunate to visit while the creek was full and running due to the recent heavy rains. It was a beautiful day and our students were exemplary environmental stewards!
See Ms. Ballard in Rm. 214 for more information!


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Q: How to fix wp_remote_get() error // get value from an array? I want to get each Bank_name on WordPress from the array while calling an external Api. I used wp_remote_get(). While doing the foreach loop with the array, I got this error:

Invalid argument supplied for foreach().

To debug the error, I tried echoing first one Bank_name by providing an index. I did exact same thing in two ways but one works and the other one doesn't. The only difference is that, one way uses wp_remote_get(), while other one uses the response as an array without calling any api.
Where is the error coming from?
This doesn't work:
    $request = wp_remote_get( 'https://tv-api-dev.azurewebsites.net/api/GetBankInfo' );
    if( is_wp_error( $request ) ) {
        return false;
    }

    $body = wp_remote_retrieve_body( $request );
    $test = json_decode( $body, true );

    print_r($test) ;
    echo $test[0]["Bank_name"];

The following works fine:
$someJSON = "[\r\n {\r\n \"Bank_id\": 1,\r\n \"Bank_name\": \"Aktia Pankki\"\r\n },\r\n {\r\n \"Bank_id\": 2,\r\n \"Bank_name\": \"Bigbank\"\r\n },\r\n {\r\n \"Bank_id\": 3,\r\n \"Bank_name\": \"POP Pankit\"\r\n },\r\n {\r\n \"Bank_id\": 4,\r\n \"Bank_name\": \"Bonum Pankki\"\r\n },\r\n {\r\n \"Bank_id\": 5,\r\n \"Bank_name\": \"Citibank\"\r\n },\r\n {\r\n \"Bank_id\": 6,\r\n \"Bank_name\": \"Danske Bank\"\r\n },\r\n {\r\n \"Bank_id\": 8,\r\n \"Bank_name\": \"DNB BANK ASA\"\r\n },\r\n {\r\n \"Bank_id\": 9,\r\n \"Bank_name\": \"Handelsbanken\"\r\n },\r\n {\r\n \"Bank_id\": 10,\r\n \"Bank_name\": \"Holvi\"\r\n },\r\n {\r\n \"Bank_id\": 11,\r\n \"Bank_name\": \"Nordea Pankki\"\r\n },\r\n {\r\n \"Bank_id\": 12,\r\n \"Bank_name\": \"OP Ryhmä\"\r\n },\r\n {\r\n \"Bank_id\": 13,\r\n \"Bank_name\": \"S-Pankki\"\r\n },\r\n {\r\n \"Bank_id\": 14,\r\n \"Bank_name\": \"Swedbank\"\r\n },\r\n {\r\n \"Bank_id\": 15,\r\n \"Bank_name\": \"Säästöpankki\"\r\n },\r\n {\r\n \"Bank_id\": 16,\r\n \"Bank_name\": \"Alandsbanken\"\r\n }\r\n]";

  // Convert JSON string to Array
  $someArray = json_decode($someJSON, true);
   print_r($someArray);        // Dump all data of the Array
  echo $someArray[0]["Bank_name"]; // Access Array data
  echo $someArray[0]["Bank_id"]; // Access Array data

From 2nd way, I get output Aktia Pankki1, which is what I expect also from the 1st way but I get this message:

Warning: Illegal string offset 'Bank_name' in
  C:\xampp\htdocs\wpsummerproject\wp-content\themes\astra\functions.php
  on line 181

A: I tried the data from the given URL. Not sure why but in the first json_decode(), the obtained value is the single JSON object with sub items. When that value is again called with json_decode() then value is obtained as an array. You may want to check in the source first how data is converted to JSON. There seems to be the problem.
$request = wp_remote_get( 'https://tv-api-dev.azurewebsites.net/api/GetBankInfo' );
if( is_wp_error( $request ) ) {
    return false;
}

$body = wp_remote_retrieve_body( $request );
$body_content = json_decode( $body, true );
$details = json_decode( $body_content, true );
print_r( $details[0]['Bank_name']);
print_r( $details[0]['Bank_id']);

A: Try:
$url      = 'https://tv-api-dev.azurewebsites.net/api/GetBankInfo';

$response = wp_remote_get( esc_url_raw( $url ) );

/* Will result in $api_response being an array of data,
parsed from the JSON response of the API listed above */

$api_response = json_decode( wp_remote_retrieve_body( $response ), true );

This is an example from codex.wordpress.org
Your link: https://tv-api-dev.azurewebsites.net/api/GetBankInfo goes to a valid json. Should work.

A: This will work in your case,
$request = wp_remote_get( 'https://tv-api-dev.azurewebsites.net/api/GetBankInfo' );
if( is_wp_error( $request ) ) {
    return false;
}

$body = wp_remote_retrieve_body( $request );
$test = json_decode( $body,true );
$test = json_decode($test,true);

echo $test[0]['Bank_name'];

redpajama_set_name: RedPajamaStackExchange


Because it will talk to you. For realzies. Just hover your smart phone over it and see your nightmares come to life. You'll want your mommy close for this. Click through for a video demonstration.
In all honesty though, it's kind of a good marketing gimmick. Strike up a conversation with X-O Manowar #1 at your local comic shop on May 2nd.
Very cool! Can we say "motion comic" coming not too long after the launch date?
Very smart way to get people to talk. And the work looks good too. Saw pages at newsarama and they look great!
Holy cow that is so cool!!! I'm surprised it wasn't thought of sooner!
Just got back from my LCS to put this in my pull list. They gave me the poster as a bonus!


Although adolescent and young adult (AYA) cancers are characterized by biological features and clinical outcomes distinct from those of other age groups, the molecular profile of AYA cancers has not been well defined. In this study, we analyzed cancer genomes from rare types of metastatic AYA cancers to identify driving and/or druggable genetic alterations.
Prospectively collected AYA tumor samples from seven different patients were analyzed using three different genomics platforms (whole-exome sequencing, whole-transcriptome sequencing or OncoScan™). Using well-known bioinformatics tools (bwa, Picard, GATK, MuTect, and Somatic Indel Detector) and our annotation approach with open access databases (DAVID and DGIdb), we processed sequencing data and identified driving genetic alterations and their druggability.
The mutation frequencies of AYA cancers were lower than those of other adult cancers (median = 0.56), except for a germ cell tumor with hypermutation. We identified patient-specific genetic alterations in candidate driving genes: RASA2 and NF1 (prostate cancer), TP53 and CDKN2C (olfactory neuroblastoma), FAT1, NOTCH1, and SMAD4 (head and neck cancer), KRAS (urachal carcinoma), EML4-ALK (lung cancer), and MDM2 and PTEN (liposarcoma). We then suggested potential drugs for each patient according to his or her altered genes and related pathways. By comparing candidate driving genes between AYA cancers and those from all age groups for the same type of cancer, we identified different driving genes in prostate cancer and a germ cell tumor in AYAs compared with all age groups, whereas three common alterations (TP53, FAT1, and NOTCH1) in head and neck cancer were identified in both groups.
We identified the patient-specific genetic alterations and druggability of seven rare types of AYA cancers using three genomics platforms. Additionally, genetic alterations in cancers from AYA and those from all age groups varied by cancer type.
Cancer is one of the leading causes of death worldwide. Abnormal genetic alterations followed by the uncontrolled growth of somatic cells initiate cancer. Although most genetic alterations are passenger mutations that do not contribute to tumorigenesis, an individual cell can proliferate and become a tumor if it acquires a sufficient set of driving mutations. Therefore, finding cancer-driving mutations and targeting the encoded abnormal proteins and related pathways via cancer therapeutics are important strategies to delay cancer progression and prevent metastasis .
Previous studies, led by The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC), have identified cancer-driving mutations via large-scale analyses . Although large-scale analyses unveiled frequently altered driving mutations in many cancer types, such as BRAF (V600E) in melanoma and colorectal cancer, finding less frequently altered mutations is a challenge using large-scale analyses, especially in uncommon cancer types [2–4].
Adolescent and young adult (AYA) cancer is a rare type of malignant disease that arises in patients aged 15 to 39 years and is characterized by biological features, therapeutic outcomes, and survival rates that are distinct from those observed in other age groups. Although determining the genomic profiles of AYA cancer is important to investigate the causes of these distinct characteristics, large-scale genomic studies or molecular data for AYA cancer are not available due to the rarity of the disease and the difficulty of collecting tumor samples [5, 6].
In this study, we analyzed seven different AYA cancers from patients with metastatic tumors using three different genomics platforms (whole-exome sequencing, whole-transcriptome sequencing, and OncoScan™). We identified single nucleotide variations (SNVs) and insertion and deletions (indels) by using whole-exome sequencing (WES) and detected fusions by using whole transcriptome sequencing (WTS). For copy number variations (CNVs), we used OncoScan™ that is the genomics platform for analysis of copy number variations which had high performance with samples from FFPE, especially . We processed the WES data with well-known bioinformatics tools (bwa, Picard, GATK, MuTect, and Somatic Indel Detector), as other studies described and processed WTS data with fusion detection tools [8–10]. We then identified candidate genes and suggested potential drugs that are specific to the genetic alterations of each patient. We also compared candidate genes for AYA cancers with the same types of cancers from all age groups using published data.
This study was approved by the Institutional Review Board (IRB) of Seoul National University Hospital (1206-086-414). We obtained written informed consent from the patients who participated to this study. All participants in this study gave us written informed consent for publication of their details. Written informed consent for publication of their clinical details and/or clinical images was obtained from the patients. A copy of the consent form is available for review by the Editor of this journal.
Samples from seven different tumors, prostate cancer, olfactory neuroblastoma, head and neck squamous cell carcinoma (HNSCC), urachal carcinoma, germ cell tumor, lung cancer, and liposarcoma, were prospectively obtained in three different forms (fresh-frozen tissue, formalin-fixed paraffin-embedded (FFPE), and pleurisy). The samples were analyzed using three different genomics platforms (whole-exome sequencing (WES), whole transcriptome sequencing (WTS), and OncoScan™) as the tumor sources permitted. We first intended to analyze samples from ten patients, but three samples were excluded because the amount of provided tumor sample was insufficient (AYA03) or sufficient DNA/RNA for a genome-scale analysis was not obtained (AYA05, and 08). For sample AYA04 (HNSCC), the HPV infection status was identified by IHC staining (data not shown).
A minimum of 3 μg of genomic DNA was randomly fragmented by Covaris, and the sizes of the library fragments were mainly distributed between 250 and 300 bp. adapters were then ligated to both ends of the fragments. Extracted DNA was amplified by ligation-mediated PCR (LM-PCR) and then purified and hybridized to the SureSelect XT Human All Exon v4 + UTR 71 Mb (Agilent Technologies, Santa Clara, CA, USA) for enrichment according to the manufacturer's recommended protocol. After loading each captured library on the Hiseq2000 platform (Illumina, San Diego, CA, USA), we performed high-throughput sequencing for each captured library. Raw image files were processed by Illumina CASAVA v1.8.2 for base-calling with default parameters, and the sequences from each individual were generated as 101-bp pair-end reads.
WES data were processed using a series of steps. We aligned the sequenced files (Fastq file) to the reference genome (human reference genome g1k v37) using the Burrows-Wheeler Aligner (BWA v0.7.5a)  and then sorted the output and removed PCR duplicates using PICARD v1.95 . Using the typical GATK workflow (The Genome Analysis Toolkit v2.6-5), we processed the data for local indel realignment and base quality recalibration . For variant calling, we used MuTect v1.1.6 for single nucleotide variants (SNVs) and Somatic Indel Detector (from GATK v2.2-8) for indels . Whereas we called the SNVs with the default setting value, we altered the tumor indel fraction from 0.3 to 0.05 (T_INDEL_F <0.05) for indel calling after considering false-negatives. The called variants interpreted as somatic mutations were tagged with "KEEP" or "SOMATIC" with MuTect and Somatic Indel Detector, respectively, and used for further study. To avoid false-positive indel variants, we filtered out variants with tumor alterative reads less than 6. All somatic variants were annotated by ANNOVAR . The variants that passed through the steps were called 'processed WES data' (Additional file 1: Figure S1).
We used the 330-k OncoScan™ FFPE platform (Affymetrix, Santa Clara, CA, USA) to identify candidate CNVs (amplification/deletion and loss-of-heterozygosity (LOH)). AYA02 was excluded because the amount of DNA was insufficient for OncoScan™. A minimum of 80 ng of DNA from each sample was used for the OncoScan™ platform. The Nexus Express (Affymetrix) software was used to analyze the data and find CNVs. We filtered out CNVs with a CN ≤ 2.5, which were considered insignificant amplification, and analyzed chromosome-level CNVs and focal level CNVs.
To analyze CNVs in AYA02, we used VarScan2 as an alternative method to OncoScan™. After processing data up to the 'Realignment/Recalibration' step in WES processing (Additional file 1: Figure S1), we processed data based on the manufacturer's recommendations. We generated mpileup data from recalibrated BAM files of both tumor and normal using SAMtools and used the 'Copy caller' module of VarScan2 to generate the relative copy number change (C), which was determined as follows: C = log 2 ((D T /D N )*(I N /I T )), where 'D' stands for the average depth, 'I' for the number of uniquely mapped bases, 'N' for normal, and 'T' for tumor [16, 17]. After filtering out mapping quality values <15, we adjusted the relative copy number using the re-centering option in 'Copy caller' and segmented copy number regions based on the circular binary segmentation algorithm. After merging, the results were represented by IGV (Integrative Genomics Viewer) . Because the VarScan2 results covered only exon regions, not all genome regions, we analyzed only chromosome-level CNVs that were similar to those obtained with OncoScan™ and did not analyze focal-level CNVs. To create graphs of relative copy number changes, we used data from re-centered relative copy number changes displayed on a log2 scale.
The mutation frequency was analyzed by counting the number of variants annotated by ANNOVAR from WES data as nonsynonymous SNVs, synonymous SNVs, nonsense mutations, stop-loss mutations, splicing mutations, frameshift insertions/deletions (indels), in-frame indels, and noncoding RNA in exonic regions. These mutations had previously been described in published data from 12 major cancer studies . To analyze the mutation spectrum, we used SNVs processed with MuTect in all sequenced regions not limited to coding regions.
After assigning the levels to the variants by pattern-based heuristic annotation, we investigated the biologic pathways of variants using DAVID or the literature . To analyze the druggability of the variants, we concentrated mainly on level-1 (strong) variants using DGIdb .
We analyzed WTS data from four samples (AYA01, 02, 09, and 10) to identify cancer driving fusions using three different fusion tools, FusionMap, deFuse and ChimeraScan [22–24]. From the results, we selected candidate cancer-driving fusions using a fusion gene list archived in COSMIC (download date: 2015-03-03).
Samples analyzed in this study were collected from AYA patients (median age = 32) who had metastatic tumors. Seven different tumor samples were obtained in three different forms (fresh-frozen tissues, FFPE and pleurisy) and analyzed using three different genomics platforms (WES, WTS and OncoScan™) (Table 1).
We processed WES data using well-known bioinformatics tools described in Supporting Fig. 1 following previously published studies [8, 10]. From the WES data of six tumors and matched normal blood, we generated total of 95 gigabases (Gb, range 12.5–20.0/sample) and 106 Gb (range 12.7–27.0/sample) of mapped sequences, respectively. The mean target coverage was 135X (range, 101X-190X) and 150X (range, 115X-205X) for tumor samples and normal blood, respectively. The coverage of mean target bases exceeded 30X for 89.8 and 92.5 % of the tumor and normal blood samples, respectively (Additional file 2: Table S1).
We analyzed the mutation frequency and mutation spectrum of six samples from processed WES data (Fig. 1). Except for AYA07, which contained a hypermutation, the coding regions (exon and splicing regions) of a total of 276 somatic mutations (median, 40; range, 26–133) were detected (Additional file 3: Table S2). Compared with the mutation frequency of 12 major cancer types obtained from published data, the somatic mutation frequency of most samples was low (median, 0.56/Mb; range, 0.37–1.87), except for AYA07 (Fig. 1a) . This finding is consistent with data showing that somatic mutations are accumulated with age . Although the mutation frequency of AYA07 was high (9.37/Mb), the overall mutation frequency of AYA cancers is low: a recent large-scale study of testicular germ cell tumors (TGCTs), the same tumor type as that of AYA07, demonstrated a low mutation frequency (mean 0.5/Mb) . Additionally, three AYA cancers with higher mutation frequencies (AYA02, 04, and 07) harbored mutations in TP53 or in several DNA repair genes compared with other samples (mean, 3.98/Mb vs. 0.44/Mb, respectively), as shown in large studies .
Except for AYA07, the mutation spectrum of AYA cancers showed prominent C > T transitions, as has been demonstrated in many solid cancers (Fig. 1b) . Interestingly, AYA07 showed a high proportion of C > A transversions (79.7 %). This result may be related to an over-representation of C > A transversions in the TCGT study  or multiple cycles of chemotherapy for the AYA07 patient, because increased C > A transversions were observed in all samples obtained from eight relapsed AML patients after chemotherapy .
After processing the WES data, we annotated variants using ANNOVAR as described in Additional file 1: Figure S1. All annotated variants are described in Additional file 4: Table S3. We then selected driving genetic alterations using our pattern-based annotation, because it is limited to analyzing rare types of cancers using the same statistical methods to select driving genetic alterations used in large-scale studies (Additional file 3: Figure S2) . By applying our approach to TCGA AML data, we could detect all candidate genes that were previously defined using statistical methods (Additional file 3: Figure S3 and Additional file 5: Table S4) .
Except for the hypermutations in AYA07, we focused on level-1 variants to identify driving genetic alterations of AYA cancers that are specific to each patient and may be druggable (Fig. 2 and Additional file 6: Table S5). CNVs were analyzed to identify candidate driving CNVs (OncoScan™) and chromosome-level CNVs (OncoScan™ or VarScan2) (Fig. 3 and Additional file 1: Figure S4).
AYA01 showed concurrent loss-of-function in genes of the RasGAP family (NF1 and RASA2). A frameshift deletion and LOH were detected in NF1, and a frameshift insertion and splicing mutation were detected in RASA2 that were validated by sequencing (Additional file 1: Figure S5). Interestingly, concurrent mutations in RasGAPs have been identified in several types of cancers according to the cBio portal (Additional file 1: Figure S6 and Additional file 7: Table S6). Furthermore, a recent study demonstrated the synergistic oncogenic effects of non-canonical Ras mutations in the context of loss-of-function in RasGAP . Because RasGAPs contribute to tumorigenesis, we suggested an MEK inhibitor (as a single agent or in combination) for the treatment of AYA01 [30, 31].
AYA02 harbored a chromosome-level alteration with a TP53 missense mutation that contributed to chromosome instability . Interestingly, AYA02 showed a double peak of a relative copy number change and arm-level alterations, which differed from other tumors (Fig. 3a and b). A loss-of-function in CDKN2C was identified with high-allelic frequency (0.667). Given the tumor suppressor function of CDKN2C in breast cancer, a loss-of-function of CDKN2C may have driven tumor formation in AYA02; therefore, we selected CDK4/6 inhibitors as a potential drug (palbociclib and LY2835219) .
AYA04 harbored TP53 mutations with alterations in FAT1, NOTCH1 and SMAD4 that have been recurrently discovered by several large-scale studies of head and neck cancer [34–36]. Specifically, AYA04 harbored concurrent mutations in Wnt pathway genes, such as FAT1, MSX1 and AXIN1, which were reported in a recent large-scale study of HNSCC with HPV (−) . We suggested potential drugs (LGK974 and γ secretase inhibitor) for AYA04 based on the importance of the Wnt and NOTCH pathways.
Because AYA06 showed only one level-1 variant in KRAS (G13D) with no candidate CNVs, we selected an MEK inhibitor (selumetinib) as a potential drug. However, a missense mutation in USP6 (R133K, Lv2 OG) was detected in AYA06 and AYA04. USP6 is known to be able to initiate tumorigenesis either in cell lines or in mice via the activation of the NF-κB pathway, although the function of the R133K variant remains elusive .
AYA07 was excluded from the identification of candidate driving genetic alterations, because AYA07 showed a high mutation frequency with many CNVs may be caused by missense mutations in six DNA repair genes (DDB1, LIG3, MNAT1, POLE, POLG and POLQ) (Fig. 1 and Additional file 4: Table S3) . The most frequently mutated gene, KIT, which was found in a large-scale study of TGCT, was not detected in AYA07 .
AYA09 was analyzed by WTS only because an IHC result for ALK was positive (data not shown). Because the EML4-ALK detected in our fusion processing is well known in lung cancer, crizotinib and ceritinib were recommended as potential drugs for AYA09 (Additional file 1: Figure S6 and Additional file 8: Table S7). The patient was treated with crizotinib and showed clinically significant tumor shrinkage, as expected.
Although level-1 SNV/indel alterations were not detected, CNVs in MDM2 and PTEN, which play a role in the p53 pathway, were identified in AYA10 (Fig. 3c). Target-specific drugs for MDM2 amplification, DS-3032b and RO6839921, plus an mTOR inhibitor, everolimus, were recommended.
To investigate differences in the genomic profiles between AYA cancers and cancers found in other age groups, we compared candidate driving genes between AYAs and all age groups for the same cancer based on published data from analyses similar to ours (Table 2). The mutation pattern of AYA01 (prostate cancer) differed from that shown in a large-scale study analysis. Whereas AYA01 harbored alterations in the Ras pathway (NF1 and RASA2), prostate cancer from other age groups showed recurrent mutations in SPOP, TP53, and PTEN . However, several commonly altered genes in HNSCC, such as TP53, FAT1, and NOTCH1, were identified in both AYA04 and in large-scale studies, whereas other mutations differed .
In this study, we described the genomic profiles of seven different rare types of AYA cancers using three different genomics platforms (WES, WTS and OncoScan™). After processing genomics data, we identified potential druggable targets for each cancer and selected existing anti-cancer drugs to treat individual patients (Fig. 2 and Additional file 6: Table S5).
We identified candidate driving genetic alterations specific to each patient using logical manual curation (pattern-based heuristic annotation) as alternative to statistical method (Additional file 9: Supplementary materials and methods and Additional file 10: Table S8). It is needed to alternative method to select candidate genes in rare type of cancers, like AYA cancers, since low number of samples is limited to the selection of candidate driving genes using statistical method as shown in large-scale studies .
Because the features of AYA cancers are distinct from those of other age groups, including the incidences and clinical outcomes, studying the genomic profiles of AYA cancers is important to identify the unique features of AYA cancers [5, 6]. When comparing candidate genes between AYAs and all age groups for the same cancer type, we identified different candidate genes in prostate cancer (AYA01) and a germ cell tumor (AYA07), although several common candidate genes (TP53, FAT1,and NOTCH1) were found in HNSCC (AYA04) in both AYAs and all age groups (Table 2). These results showed that AYA-specific genetic alterations may be different from those in other age groups; thus, further study is needed to define the significance of the differences in the genetic alterations between AYAs and other age groups.
In this study, we analyzed individual cancer genomes and suggested potential drugs for each patient based on his or her genetic alterations. Characterizing the genomes of patients and genomics-driven knowledge enabled personalized medicine and advanced cancer genomics for clinical implications . Moreover, to establish the clinical validity of genetic tests, especially for NGS data, the FDA discussed 'post-marketing pursuit' to define the clinical implications of variants generated from NGS, which have remained unknown . Therefore, we expect many prospective genomic studies, such as our study, to link the patient to therapy as well as diagnosis, prognosis, and monitoring .
We analyzed seven different metastatic AYA cancers' genome, and potential targets were identified. Genetic alterations in cancers from AYA and those from all age groups were varied by their cancer type.
This study was supported by grant 03-2014-0290 from the Seoul National University Hospital Research Fund. This research was also supported by the MSIP (The Ministry of Science, ICT and Future Planning), Korea and Microsoft Research, under the ICT/SW Creative research program supervised by the NIPA (National ICT Industry Promotion Agency)" (NIPA-2014-ITAH051014011012)". We thank Ji-Eun Yoon and Su Jung Huh for collecting the tumor tissue samples and matched normal blood as well as for extracting genetic materials. Additionally, we thank Jiae Koh for revising the draft.
SC, SHL, JIK designed the study. SC, SHL drafted the manuscript. SC, JL, JYS performed experiment and data analyses. JYK, SHS, BK, TMK, DWK, DSH participated in critical review of study design and data analyses, SC, JL, JYS, JYK, SHS, BK, TMK, DWK, DSH reviewed the manuscript and criticized it. All authors read and approved the final manuscript.


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Stories from The Edge: WELL SAID MALORIE BLACKMAN!
In a week when our children's laureate, Malorie Blackman, received an outpouring of racist abuse after calling for more diversity in children's books Paula Rawsthorne says that the haters have inadvertently helped to raise the profile of this important issue.
Sky News was wrong and unprofessional to label Malorie's interview with an inaccurate, inflammatory headline quoting her as saying children's books "Have too many white faces". Sky apologized and changed the headline to "Call for more diversity in kids' books" but the damage was done and Malorie still received abuse on the Sky website and through twitter.
What Malorie Blackman was saying was hardly radical or inflammatory and the subsequent abuse is a disgrace but it has led to more articles and debate about this issue and the widespread support for her reinforces to me that the haters are in a tiny minority.
A call for more diversity shouldn't be controversial. Of course we need to see more diversity and inclusion in books, not just in ethnicity but representing kids from all walks and ways of life. This isn't political correctness, it's just makes sense for stories to reflect the world around us and it's only right that children get to see characters that they can identify with.
I'm a white woman but in my books I have significant black characters. Why? Well, why not? I write contemporary fiction that reflects the society we live in, it's been appropriate for my stories and yes, it does unsettle me that there are groups of children who don't often see people like themselves represented in books.
Although it's great seeing diversity and inclusion in books it shouldn't ever be about ticking boxes. The primary aim of a story is to entertain. 'Diverse' characters aren't there to act as role models or teach the reader lessons. 'Diverse' characters should feel as real as any other creation in a book and that means that they should be an integral part of the plot, fully rounded and multifaceted, not caricatures or patronisingly portrayed as saints who can do no wrong.
I once had a conversation with someone in publishing who was uncomfortable that one of the 'baddies' in my story happened to be black. She said that it could send out the wrong message. I was rather taken aback and pointed out that the main 'baddie' in the story happened to be a white bloke (and the 'heroine' happened to be mixed race). These creations weren't 'goodies' or 'baddies' by virtue of the colour of their skin. Their actions and behaviour were character led, not colour led. It seems dishonest and unrealistic to portray any non-white characters as paragons of goodness for the sake of political correctness.
When I look at my kids and their friends, their differences don't seem to be an issue for them. The fact that they may be different colours, abled bodied or less abled bodied, religious or no religion, isn't even commented on because it's of little significance to them. They're just friends with loads in common, having a good time. So how odd that when these kids pick up most books a proportion of them suddenly find themselves invisible.
So I say, ignore the tiny minority of bigots who respond with abuse to calls for more diversity and inclusion in children's books. What Malorie Blackman is asking for is just common sense; it will help stories reflect the world we live in and, in so doing, make it a better place for everyone.
And well said, Paula! I great post. the more it's talked about the more ears may hear the call for more diversity.
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Tiddler is a little fish who tells the tallest tales in the ocean. But did he really ride a seahorse? Did he really meet a mermaid? And what about the scariest story of all - the one about the fishermen and the net! Brilliantly performed by award-winning actress Imelda Staunton, this audio download contains the complete, best-selling story with music, the Tiddler Song, and a listening game.
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Q: Am I seeing an optimisation bug when iterating through a list in C? I have been working on integrating a colleague's software library into our larger application.  He has been writing and testing his library under -O0 on gcc 4.9.3.  This is embedded software for an alarm system.  This bug is observed under -Os optimisation and we are using straight C (none of that C++ nonsense), also on gcc 4.9.3.  The architecture is ARM Cortex-M4F.
I am experiencing an issue with integrating that code into the larger stack.  The below code should iterate through at most GLOBAL_MAX_DEVICES until it finds a free space in the table to insert its entry:
RET_VALUES DEVICE_Add_To_New_Table( uint8_t *new_id, uint16_t unique_id )
{
    RET_VALUES ret_value = RET_OK;
    uint8_t pos = 0;

[...]
    else
    {
        debug_print( "A,", true, DEBUG_DEVELOP_MODE_PLAIN, DEBUG_TRACE );

        // See if the unique_id is already in the table (relearn)
        while(( unique_id != DEVICE_new_table.unique_id[pos] ) && ( pos < GLOBAL_MAX_DEVICES ))
        {
            debug_print( "B,", false, DEBUG_DEVELOP_MODE_PLAIN, DEBUG_TRACE );
            pos++;
        }
[...]

The problem we are experiencing is that instead of the loop iterating GLOBAL_MAX_DEVICES times (currently 13) it iterates over 200 times.   The sequence "B," is printed out multiple times in the while(( unique_id != DEVICE_new_table.unique_id[pos] ) && ( pos < GLOBAL_MAX_DEVICES ))   loop.
Three changes can be made which resolve this issue;

*

*pos can be made a volatile, which (I believe) inhibits some optimisation on this value.

*The parameters in the while block can be reversed, forcing evaluation of pos < GLOBAL_MAX_DEVICES to occur first.

*It is possible to add a build flag, -fno-aggressive-loop-optimizations, to turn off some loop optimisations.
Only one given fix is required, it appears, to resolve the issue.
I initially thought the issue may be down to a short-circuit optimisation.  But, I can confirm that the unique_id parameter is not zero (it is 0x042b on this sample), and DEVICE_new_table is initialised to all zeroes in the unique_id field of the struct.  And, in any case, even if the first argument is true, the latter should still be evaluated; short-circuiting should only apply if the first is false, which is clearly not the case, at least not initially, because the loop is iterating for some time.
I am therefore confused as to why this loop iterates hundreds of times (I presume eventually a collision with a memory address occurs, which causes a chance match against the unique_id, possibly with a value in the stack.) Adding a print statement into the loop that prints the iterator pos causes the loop to run over 13,000 times.  13,000 is much bigger than 13, I have checked several times.
Comparing the machine code produced by the broken sample (with additional printf statement added) and working sample (also with printf) shows that the working variant, with the arguments in the boolean operator reversed, includes a comparison with the iteration maximum of 13.
Broken:
        debug_print( "A,", true, DEBUG_DEVELOP_MODE_PLAIN, DEBUG_TRACE );
    ea7a:   4822        ldr r0, [pc, #136]  ; (eb04 <DEVICE_Add_To_New_Table+0xb0>)
    ea7c:   f8df 80a4   ldr.w   r8, [pc, #164]  ; eb24 <DEVICE_Add_To_New_Table+0xd0>
    ea80:   2101        movs    r1, #1
    ea82:   2200        movs    r2, #0
    ea84:   2306        movs    r3, #6
    ea86:   f00b fef9   bl  1a87c <debug_print>

        // See if the unique_id is already in the table (relearn)
        while(( unique_id != DEVICE_new_table.unique_id[pos] ) && ( pos < GLOBAL_MAX_DEVICES ))
    ea8a:   2400        movs    r4, #0
    ea8c:   f838 3f02   ldrh.w  r3, [r8, #2]!
    ea90:   454b        cmp r3, r9
    ea92:   b2e7        uxtb    r7, r4
    ea94:   4626        mov r6, r4
    ea96:   f104 0401   add.w   r4, r4, #1
    ea9a:   d00c        beq.n   eab6 <DEVICE_Add_To_New_Table+0x62>
        {
            uart_printf(-1, "%d,", pos);
    ea9c:   4632        mov r2, r6
    ea9e:   491a        ldr r1, [pc, #104]  ; (eb08 <DEVICE_Add_To_New_Table+0xb4>)
    eaa0:   f04f 30ff   mov.w   r0, #4294967295
    eaa4:   f7f8 ff6c   bl  7980 <uart_printf>
            debug_print( "B,", false, DEBUG_DEVELOP_MODE_PLAIN, DEBUG_TRACE );
    eaa8:   2100        movs    r1, #0
    eaaa:   4818        ldr r0, [pc, #96]   ; (eb0c <DEVICE_Add_To_New_Table+0xb8>)
    eaac:   460a        mov r2, r1
    eaae:   2306        movs    r3, #6
    eab0:   f00b fee4   bl  1a87c <debug_print>
    eab4:   e7ea        b.n ea8c <DEVICE_Add_To_New_Table+0x38>
            pos++;
        }

Working (trimmed unnecessary parts), note the cmp r4, #13 statement at eab2 which is absent in the broken sample:
        debug_print( "A,", true, DEBUG_DEVELOP_MODE_PLAIN, DEBUG_TRACE );
    ea7a:   4845        ldr r0, [pc, #276]  ; (eb90 <DEVICE_Add_To_New_Table+0x13c>)
    ea7c:   f8df 8148   ldr.w   r8, [pc, #328]  ; ebc8 <DEVICE_Add_To_New_Table+0x174>
    ea80:   2101        movs    r1, #1
    ea82:   2200        movs    r2, #0
    ea84:   2306        movs    r3, #6
    ea86:   f00b ff4d   bl  1a924 <debug_print>
    ea8a:   4647        mov r7, r8
    ea8c:   2400        movs    r4, #0

        // See if the unique_id is already in the table (relearn)
        while(( pos < GLOBAL_MAX_DEVICES ) && ( unique_id != DEVICE_new_table.unique_id[pos] ))
    ea8e:   f837 3f02   ldrh.w  r3, [r7, #2]!
    ea92:   454b        cmp r3, r9
    ea94:   b2e5        uxtb    r5, r4
    ea96:   d00f        beq.n   eab8 <DEVICE_Add_To_New_Table+0x64>
        {
            uart_printf(-1, "%d,", pos);
    ea98:   4622        mov r2, r4
    ea9a:   493e        ldr r1, [pc, #248]  ; (eb94 <DEVICE_Add_To_New_Table+0x140>)
    ea9c:   f04f 30ff   mov.w   r0, #4294967295
    eaa0:   f7f8 ff6e   bl  7980 <uart_printf>
            debug_print( "B,", false, DEBUG_DEVELOP_MODE_PLAIN, DEBUG_TRACE );
    eaa4:   2100        movs    r1, #0
    eaa6:   483c        ldr r0, [pc, #240]  ; (eb98 <DEVICE_Add_To_New_Table+0x144>)
    eaa8:   460a        mov r2, r1
    eaaa:   2306        movs    r3, #6
    eaac:   3401        adds    r4, #1
    eaae:   f00b ff39   bl  1a924 <debug_print>

        // See if the unique_id is already in the table (relearn)
        while(( pos < GLOBAL_MAX_DEVICES ) && ( unique_id != DEVICE_new_table.unique_id[pos] ))
    eab2:   2c0d        cmp r4, #13
    eab4:   d1eb        bne.n   ea8e <DEVICE_Add_To_New_Table+0x3a>
    eab6:   4625        mov r5, r4
        {
            uart_printf(-1, "%d,", pos);
            debug_print( "B,", false, DEBUG_DEVELOP_MODE_PLAIN, DEBUG_TRACE );
            pos++;
        }

I feel like a programmer blaming his tools is admitting defeat, but I really can't see how this is anything other than a compiler bug.  If anyone has any ideas, I would appreciate the input.

A: As indicated in the comments, this is bug in your program, namely a simple out-of-bounds access of the array.
Given GLOBAL_MAX_DEVICES = 13, then you end up accessing DEVICE_new_table.unique_id[13] and beyond. In debug build you might have a zero there and it "works" by chance. Then in release you get some non-zero value and the loop goes haywire, short-circuiting away the loop terminating condition.
Also, if your code contains undefined behavior such as out-of-bounds access, you can get really strange machine code generated when the optimizer attempts things like loop unrolling. Like for example the compiler may reason as: "okay this first check is always true since all items in the array are zero, so we can remove the check after && entirely".
This could be fixed by writing the loop in simpler ways. Assuming you wish to preserve the value of pos after the loop(?), then do this:
uint8_t pos = 0;
...
for(; pos<GLOBAL_MAX_DEVICES; pos++)
{
  if(unique_id != DEVICE_new_table.unique_id[pos])
    break;
  debug_print(...);
}


Bad decision on his part. Next year the Cards might be trading him. Lol.
After three months of talking about flashy players and what-ifs, teams go back to the tried-and-true. If he's available at 15 the choice for me comes down to OT versus Edge. Williams and Wiliams on the left side - - - that's a nice fantasy but not likely for many reasons. Any player rising means that someone is falling. I just hope that history repeats itself and the QBs all go early as that leaves more options for the Skins.
If there's no sure-fire player then other teams are unlikely to want to trade up. As you said - - too much talent available at picks 20-100. Only 14 players get selected before the Skins so any of the ones listed could be available. Some are more likely than others. I think the choice seems to come down to Jonah Williams OT; Ferrell or Burns (Edge), or Hockenson. I'd be happy with Williams or Hockenson. I'd be happy if the Skins select an Edge. Ferrell versus Burns would be an easier decision if I knew how the Skins intend to use the player. The analysis on Ferrell sounds like he'd be better as DE. Burns has potential to be more of the OLB rush and cover hybrid player. Front office needs to be on the same page as coaches.
At this point pre-draft I look at a mock draft to see who they thought would be available but wasn't picked. It's interesting to see the pick when you know the choice is between two specific players, e.g., Derwin James and Daron Payne. One recent mock had the following players available when the Skins are on the clock (no trade down): Devin Bush (LB), Clelin Ferrel (Edge); Brian Burns (Edge); Jonah Williams (T); Cody Ford (G/T); Greedy Williams (CB); and Hochenson (TE). You can't pick assuming that you will be able to fill a different position with a quality player in rounds 2-3. Assume a 50-50 possibility that your other high need position may not be available at appropriate value until round 5. So who do you pick?
OL has been discussed at various points over the last several dead football months. The OTs that come up most often as first round picks include: Jawaan Taylor, Andre Dillard, Jonah Williams and Cody Ford. Ford is often listed as a G rather than T. Casserly likes Greg Little but others peg him as 3rd round talent. I don't think anyone expects Taylor to drop to 15. Dillard and Williams are certainly possibilities depending upon whether teams go early for QBs and Edge rushers. Dillard is the best pass protector and that will be highly valued by a pass-heavy team. I think Ford will have an issue in that he's been pegged by some as a G and there are many Guards available in the 2nd round. The one that may be #15 value and may be there when the Skins pick is Williams. If this happens and Skins pick him I would not be livid. It would be a smart move IMO. He either plays LG immediately or takes over at LT now and Trent moves inside. A quality Tackle is worth a first round pick.
You are beating a dead horse. I think most will agree that draft assets should be applied to the OL but we don't agree with your prescription.
The draft seems to have good depth at TE and the position is a big need for the team. The moons have aligned so now the Skins just have to execute the plan. Right scheme; right play call; he's wide open; d'oh! butter-fingers drops the ball. Those days are over...….right?
All true but I'm still not slotting the first two picks for the OL. Give me an OT that can play G for a year before switching to T. Use a 5th round pick for a Guard that can step up after a year.
Of those three I'd rather the Skins go with Jonah Williams. He fills a short term and long term need and is appropriate value at 15. I'm not sure that the Skins would use Brown appropriately - if they ask him to block or use him on screens the LBs may break him like a toothpick. Oliver and Wilkins are both intriguing but there's a log jam on the Dline - Settle and Brantley need more playing time. If the Skins can re-sign Ionnanidis to a reasonable contract then that would be preferable to drafting another DT/DE in round 1. If they think they will have to let Ionnanidis go then I'd take the DT if the Skins think they can trade him for picks (greater pick value than an expected comp pick).
What attributes do you think the Skins should look for in an OLB? A Kerrigan clone? A guy that can both rush and drop and cover? Is Ferrell best suited as an OLB or as a 4-3 DE? Is he best suited to their nickel defense? I think Ferrell will likely be available at 15 and perhaps somewhat lower. Is he a "difference maker" that Gruden covets (not that pre-draft comments mean anything).
Skins do have a need for a difference maker at any of a number of positions. The concern that everyone has is whether any of the available players at 15 will be a difference maker along the lines of Derwin James or just a solid blue chip type. The overall roster has improved - players that are cut are now picked up by other teams (it wasn't always so!!!!!). But yes there aren't enough impact players. Draft QBs will affect the Skins' options tremendously. Teams aren't going to pass on top edge rushers; and you will always have the truly elite DTs and OTs go; then it's a question of individual players: one WR? a TE? one or two CBs? ILB? Who knows. I'm ready to find out. I'm back to Edge; TE; WR; G/T in the first four picks. But each player has to fit what the Skins are trying to do. I have my wish list but it's more important that the player have a productive career with the Skins. Lastly, I'm hoping the Skins can take advantage of DL depth after the "top" players have been picked - one guy that is ready in year 2 would be perfect.
The BPA for the second round pick may be Josh Rosen. But, yes I agree that "win now" is not a good philosophy for this team. I disagree that letting Kirk go was a bad decision. He was never worth that contract. The error was trading the 3rd and slot CB for a 34 yo QB. Hindsight is 20-20 though. If Smith had been as good as hoped we probably would be saying the trade was worth it. The 3rd round pick doesn't always pan out and Fuller may have regressed with the Chiefs. Still, a well run team would never have gotten into this position in the first place.
Flowers at Guard is nothing more than hope at this point. But, yes they may not think of Guard as an absolute need going into the draft. Sometimes a quality player falls into your lap though so who knows? If Flowers turns out to be good at Guard then the Skins would at least have a starter and upgraded depth. After all of the injuries the last two years I wouldn't mind if the Skins go OL in the first round. What if they can't extend Scherff? Immediate need and near term planning support devoting some draft pick(s) to the OL if there's appropriate value.
Cards are hyping everything up as much as possible to get greater value from the #1 pick or greater value for Rosen. There are multiple suitors! Multiple picks offered already! I hope the Skins let the football guys make these decisions. I'm sure Jay Gruden would like Rosen but the issue is always the cost to get him. My gut feel is that the Skins are going to do their best to get Rosen. If they do, then I think the Skins need to go all-in to help the offense succeed this year. If the Skins trade their second round pick then they almost have to trade down from #15 to recoup a high pick to use on the offense. I had suggested swapping #15 for the Cards first 2nd round pick. There are many possible scenarios but the idea is to keep 4 picks in that lower first, second and third rounds. Then go G/T, 1-2 WRs, and TE wherever the best value/fit for the team. Of course, you can't completely ignore other positions of greater value but the strategic goal would be to let Rosen actually develop into your hoped for franchise QB. If one of the top 4 picks is for a higher value defensive player then so be it but the G and WR positions are a must. Skins can get by with a lower TE but not with the existing depth at Guard or WR.
Brian Burns seems to have dropped in recent drafts. Clelin Ferrel is interesting but I thought he was projected to be a better fit as a 4-3 DE. Your list includes only one Tackle and it may be that you only want Jawaan Taylor (very unlikely to fall to #15). Other top rated tackles Andre Dillard or Jonah Williams might be picked early and, if so, that will make another player on your short list available.


text:
Q: Debian mirror syncing error I'm running the Debian mirror syncing tool 'ftpsync' on a FreeBSD 8.2 system. I changed the script a bit only to adapt to the FreeBSD system (e.g., path of bash). And I followed the steps from http://www.debian.org/mirror/ftpmirror to setup the mirror site.
The script is put in the cron job and will be run everyday. From time to time, I see the following error message in the log files which looks like:
file has vanished: "/pool/main/g/gcc-snapshot/.gcc-snapshot_20120625-1_s390x.deb.1cqlSA" (in debian)
rsync warning: some files vanished before they could be transferred (code 24) at main.c(1518) [generator=3.0.9]

If this error occurs, two files starting with 'Archive-Update-in-Progress-' and 'Archive-Update-Required' will appear in the mirror repository.
It seems that some files have been updated during the syncing from the upstream. If I run the 'ftpsync' script again by hand, both files will disappear and the issue will be resolved.
Do you have  any idea on how to get rid of this problem other than running the script again manually? Thanks.

A: You could wrap ftpsync in a shellscript like this:
#!/bin/sh
ftpsync
while [ -f /pool/main/Archive-Update-In-Progress ]; do
   sleep 600
   ftpsync
done

This will update the repo until the Archive-Update on the other side is done.

A: As far as I know: You can't! Only if you know what these files look like, you will be able to exclude them from the rsync call.
It seems that those files are temporary ones and disappear during the file transfer.


Heat open six-game road trip against explosive Suns - NBA - Are You Watching This?!
PHOENIX (Ticker) -- The Miami Heat seek to snap a season-high four-game losing streak when they open a road trip against the explosive Phoenix Suns on Friday.
Interim coach Ron Rothstein guides the team for the second time since being named to replace Pat Riley, who took a medical leave of absence to take care of ongoing knee and hip problems.
Last season's NBA Finals MVP, Dwyane Wade has missed Miami's last three contests with a sprained right wrist and superstar center Shaquille O'Neal has been sidelined for 24 games after knee surgery. The Heat have dropped all five games this season when both are out.
Jason Kapono scored 19 points and Robert Hite added a career-high 16 of the bench for Miami, which allowed the Los Angeles Clippers to shoot nearly 61 percent (46-of-76) from the floor in Wednesday's 110-95 loss.
Since their franchise-record 15-game winning streak from November 20-December 19, Phoenix has won five of seven, including its last four games. The Suns are one of three teams (Dallas and Utah) with fewer than 10 losses this season.
Raja Bell scored 17 points and Steve Nash and Boris Diaw added 15 each for Phoenix, which won for the 13th time in 14 games against Eastern Conference foes with Wednesday's 100-98 triumph over the Toronto Raptors.
The Suns have taken 11 of the last 17 encounters against the Heat, including a 99-89 victory on December 13. Nash collected 18 points and 11 assists.


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Halsey Announces North American 'Manic' Tour
Jacklyn Krol Published: January 8, 2020
Tim P. Whitby, Getty Images for MTV
Halsey is launching her North American Manic Tour this summer.
The 25-year-old will kick off the North American leg of her world tour on June 2 at White River Amphitheatre in Seattle, Washington and wrap up on August 1 in Irvine, California at FivePoint Amphitheatre.
Joining Halsey for the first half of the tour from June 2 - July 5 will be CHVRCHES and Omar Apollo and from July 12 - August 1, blackbear and PVRIS will join the tour.
Fans can gain access during Halsey's artist presale which begins tomorrow (January 9). Citi cardmembers can gain access to their presale on January 13 at 10 AM local time through January 16 at 10 PM local time.
Tickets will go on sale to the general public on January 17 at 10 AM local time. All tickets for the North American leg will also include a copy of Halsey's third studio album, Manic, which debuts on January 17.
See below for the North American tour dates.
Manic World Tour – North American Leg
6/2 - Seattle, WA - White River Amphitheatre
6/4 - Portland, OR - Sunlight Supply Amphitheater
6/6 - Mountain View, CA - Shoreline Amphitheatre
6/7 - Sacramento, CA - Golden 1 Center
6/10 - Los Angeles, CA - Hollywood Bowl
6/13 - Phoenix, AZ - Ak-Chin Pavilion
6/15 - Dallas, TX - Dos Equis Pavilion
6/16 - Houston, TX - The Cynthia Woods Mitchell Pavilion
6/18 - Charlotte, NC - PNC Music Pavilion
6/21 - Cleveland, OH - Blossom Music Center
6/24 - Atlanta, GA - Cellairis Amphitheatre at Lakewood
6/26 - Detroit, MI - DTE Energy Music Theatre
6/27 - Chicago, IL - Hollywood Casino Amphitheatre
6/30 - St. Paul, MN - Xcel Energy Center
7/1 - Kansas City, MO - Sprint Center
7/3 - Milwaukee, WI |-Milwaukee Summerfest
7/5 - Boston, MA - Xfinity Center
7/12 - Toronto, ON - Budweiser Stage
7/15 - Forest Hills, NY - Forest Hills Stadium
7/18 - Holmdel, NJ - PNC Bank Arts Center
7/19 - Columbia, MD - Merriweather Post Pavilion
7/22 - Tampa, FL - MIDFLORIDA Credit Union Amphitheatre
7/24 - Nashville, TN - Bridgestone Arena
7/25 - St. Louis, MO - Hollywood Casino Amphitheatre
7/27 - Morrison, CO - Red Rocks Amphitheatre
7/30 - Salt Lake City, UT - USANA Amphitheatre
8/1 - Irvine, CA - FivePoint Amphitheatre
Source: Halsey Announces North American 'Manic' Tour
Filed Under: Halsey
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Halsey Will 'Never' Get Their 'Pre-Baby Body Back,' And She Doesn't Want To
Halsey Expertly Trolls Christian Op-Ed Claiming They're 'Disrespecting Catholic Iconography'
Halsey Says Katy Perry's 'Teenage Dream' Is the Perfect Pop Album
5 Times Halsey Proved They Could Absolutely Rock
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Halsey Shares First Photos of Newborn Baby: 'Powered By Love'

redpajama_set_name: RedPajamaCommonCrawl


Our private jungle garden is only a 10 minute walk to world class surfing! You are also near coffee shops, açaí shops, restaurants, bars and pizza and at the same time you will feel like you are away from it all. Explore the great snorkeling spots, take a surf lesson or spend the day lounging in one of the hammocks using the tree top yoga deck or chilling and grilling at the tiki bar or fire pit! We really are a nature lover and/or surfers dream come true. 2 of our casitas have 3 twin cots in them. One has 2 twin beds and 2 futons. All have their own separate private bathroom with the most amazing river stone floor showers.
Have a question? Send Renee a message!
We offer surf board and paddle board rentals. Surf lessons and paddle board tours!
Natural features you'll find at Samatahiti, Ocean-view Jungle Oasis in Puerto Rico.
The eco resort is located in the valley behind my home. Nestled in your own private jungle garden but close enough to wake to the sounds of the waves crashing and a 10 minute walk to either world class surfing and a swimming beach depending on which way you go!
Lovely oasis. I would definitely stay here again and encourage friends to stay here as well. Tucked away very close to the beach but far enough away that there was ample room to spread out on a hammock in the afternoon's dappled sunlight or do yoga. The sounds at night are just like the sounds in the middle of the empty rainforest --magical. We didn't use the tiki bar but it looked like an awesome place to hang out and eat/drink. Each cabin has a private outdoor shower, sink and toilet in a separate little hut, divided and shared with another cabin. Stay here if you love the outdoors and care more about the ambiance and environment than your bed accommodations.
Yummy foods in walking distance: Playa Bowls and Queviva. Acai bowls, smoothies, juices and pizza, salads. Rent boards from Renee at a cheaper price than the spots on the beach.
If you've fully explored and read the information on this listing page and still have questions, you can message Renee here.


Today's victory is brought to you by David.
David has a compulsion about electronic gadgets. He takes them. Doesn't matter who they belong to.
Today he took his brother's cell phone.
Tonight, David gave it back without a fit, any lies, or a tantrum.
If it only happens once in a while where he is honest about his takings, and gives things back, that is a victory. Eventually, maybe we can get him trained to stop stealing. But it is huge that he gave an item back without a meltdown.
« What do Ronald McDonald and Houdini have in common?


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I think freshwater shrimp is a very optimistic creature. It's common for these shrimps to jump out from pond to pond to find a better source of food and water. So in my case... I had 2 shrimps, one of them is the hero in this comic and the other one is still alive in my tank.


Antonis Myrodias was born in Athens. He is a sculptor and he has his atelier in Athens, Greece. He studied in Athens, Greece and Florence, Italy. He has participated in many exhibitions and symposiums. He was awarded for his work in various competitions.
Title of the project : "Νίκη" │"Nike".
Concept: The sculpture is an abstract study in the figure of "Nike". The dynamic geometrical forms try not to describe but to express the action and the movement "in front", an impress increased by the design of the base.The composition refers to the Victory, as a dream, hope and confirmation in wide or individual struggles, interpersonal relationships or even in the overcoming of the human itself.Moreover, for me this "Nike" stepping in the edge of a ship "bow", sailing over the Mediterranean Sea is a wish and a hopeful vision for a prosperous and peaceful future for the island.


text:
Alex Moreland | Writer
Extended works of fiction about imaginary success
Writing Portfolio & CV
Ten Years of the Tenth Doctor: Doomsday
July 8, 2016 July 17, 2018 ~ alexmoreland	~ Leave a comment
Same old life. Last of the Time Lords.
There are some things which are pretty self-evident about Doctor Who, when it comes down to it. Ideas which, as soon as they've been brought up, practically beg to be incorporated into the show – in fact, not just beg, but need to be used. Of course the Time Lords would be the ultimate villains of the Time War (I'm getting ahead of myself there, though). Of course the Doctor is friends with all these different historical figures.
Of course the Cybermen and the Daleks should meet.
And of course they should fight each other.
Russell T Davies once described it as sounding like "bad fan-fiction" and… on the one hand, I can sort of understand what he means. There's something very gratuitous about it; when you think about it, there's not really any reason for the Daleks and the Cybermen to meet one another outside of the fact that they're the two famous Doctor Who monsters. If it was any other pairing, it wouldn't quite have the same weight (although I look forward to the eventual Ice Warriors vs Sontarans story).
Yet, at the same time, that's exactly why it appeals – the reason why it has that fanfiction attraction. The sheer insanity it symbolises, to finally bring these two together; that's fantastic, to steal from the Ninth Doctor. With this story, Davies is quite literally bringing to life the imagination of every fan. There's something about Doomsday that consistently goes further, time and time again, to properly realise everything that we've always held in our heads; even Verity Lambert herself highlighted the spectacle of seeing the Daleks swarming across London in their thousands. In a way, there's something quite special about that.
In many ways, I think Doomsday contains what I would consider to be the archetypical depiction of Daleks – cruel, scheming, and full of hate. Brimming with evil, and genuinely quite deadly. And yet, at the same time… just a little bit snarky. A cruel edge of sarcasm and smug superiority. For me, this is the definitive image of the Daleks – likely because, thinking about it, this would have been my first proper Dalek story. All others have been measured against this one.
And it's rather impressive for a Dalek story, isn't it? I'm very fond of the Cult of Skaro in particular, actually; they're a brilliantly innovative concept. They do the wonderful trick of elevating the Daleks from monsters to villains – in this story and subsequent ones, that is, and I don't mean to suggest it's never been done before – which helps to make the interactions between Doctor and Daleks far more nuanced, and indeed far more compelling to watch.
There's a lot else to like in this episode, of course; I'm going to take some time to highlight those things, because I don't want to let the drashig in the room overshadow the rest of what makes this episode such a great piece of television – the final ten minutes are great, and they are iconic, but the rest of it is pretty damn brilliant too.
I always comment on Russell T Davies' character work, because I do think it's his chief strength as a writer; I'm going to be talking about that a lot in a moment, specifically in terms of the Doctor and Rose, but I think it's worth taking a moment to look at all the other impressive character moments that are on display in this episode.
Principally, you've got Jackie and Pete; just as much as this is the ending of Rose's story, it's also the ending of their story. It's nice, then, to be able to see the pair of them finally reaching a sort of happy ending together – it goes to show you just how effectively Doomsday acts as a series finale not just to the second series of Doctor Who, but also to the past two years of the program.
We also get the opportunity to see Mickey in hero mode; after Rise of the Cybermen and Age of Steel, he'd completed his hero's journey, and now we're looking at the end result. It's fascinating to compare the Mickey we see here – self-assured, confident, and the "bravest human" Rose had ever known – to the jumpy, frightened young man of Rose. It's a testament to those involved, then, that this evolution feels earned; you can understand the journey, and you can understand why Mickey is who he is now. (Incidentally, I've gained a lot of respect for Noel Clarke over the past few weeks, simply because I've found out a lot more about the rest of his career. He seems to do a lot of interesting things; definitely going to have to search out his Hood movies and watch those.)
Similarly, Rose's own hero's journey comes to a fore this week; she stares down the Daleks, she makes the final sacrifice, and she chooses Doctor-life over any other. Over on Pete's World, she becomes a 'defender of the Earth' – the Doctor for a world that doesn't have one. It really is very reminiscent of the journey that Clara went on; I know a lot of people draw parallels between Clara and Donna, but I definitely feel like Clara and Rose have a lot in common with one another.
One final aspect worth commenting on, though, before moving on to the main event: Yvonne Hartman. I mentioned last week how impressive I found her character – and now, this week, we get to see her tragic downfall. At the same time, though, there was something of a triumph to her tragedy; Yvonne is the only character we've seen with a resolve strong enough to resist the Cyber conditioning. It's perhaps ironic that she gets her only 'moral' moment of the two-parter when she's been converted; a parallel, maybe, with how Torchwood was always appropriating alien technology for its own benefit. Even in death, Yvonne is still doing what she's always done.
(And I bloody love that single, solitary tear. It's one of those defining Doctor Who images which has always stayed with me.)
Of course, there's only really one thing that Doomsday is known for. That scene. Possibly one of the most iconic scenes of Davies' Who, if not the entirety of Nu-Who as a whole. It is quite the scene.
For a Yahoo article a while ago, I wrote this about the scene:
It's the culmination of a two-year plot arc, and it is heartbreaking. All of us in the audience have watched these two characters travel together, and grow together, ever since the show returned; it was with the Tenth Doctor that we really saw the depth of feeling these two characters had for each other. And yet, in the end, the Doctor and Rose were ripped apart from each – it was cruel, it was unforgettable, and it was wonderfully written by the fantastic Russell T Davies.
And, you know, that's completely right. But it's also a huge oversimplification of what's really going on in the scene; that, admittedly, was because I was writing it largely from memory, without a proper understanding of the context of the scene.
It's not just about seeing the depth of feeling this two characters have for each other – it's the moment when they finally admit to each other how they feel. Because so far, they haven't; I've pointed out over my previous reviews that the love story between the Doctor and Rose is, in fact, quite subtle. They weren't ever really in a relationship together; it was never anything that complicated, or that mundane. It was just the Doctor and Rose, in the TARDIS. As it should be.
But that's what really emphasises the tragedy of this moment – there was a sort of purity to it, because it was the first time that the pair of them expressed these feelings. The first time they chose to, because it was the last time they could. Which serves only to heighten the sheer cruelty of "Rose Tyler, -", in the end – we know what he was going to say, but it's just not fair that he didn't get to say it. (All the more frustrating, really, that the pair of them wasted time on little small talk; in a way, though, that makes the moment all the more effective. These two inarticulate idiots, dancing around their feelings – and, in the end, denied even that one final moment together.)
Tennant and Piper are, frankly, perfect here. I'm inclined to say that Billie Piper does better here even than in Father's Day, with her grief open and raw. Similarly, Tennant does an impressive job of just barely holding it together – wonderfully delivering the Doctor's ever so slightly dismissive jokes, he really conveys quite how sad the Doctor is. It's a poignant moment, and I must admit that it had me on the edge of tears. Russell T Davies really managed something special here, it has to be said.
Ultimately, Doomsday is a brilliant episode of Doctor Who. It's a fitting resolution to the second series of Doctor Who, a wonderful ending to Rose Tyler's story – and most importantly of all, it's got a clever hook for the start of next year.
(This time next week, there will be an overall series review & retrospective, and the following week there's going to be a general analysis on the Tenth Doctor in his first year.)
Ten Years of the Tenth Doctor Reviews
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Omari Douglas on It's A Sin, moving from stage to screen, and more January 18, 2021
Doctor Who Review: Revolution of the Daleks January 3, 2021
On 2020 January 1, 2021


My first experience of democracy-in-being followed swiftly upon boarding the steamboat for San Francisco, when "Show this man Number 231" was the American steward's command to a cabin boy. I had no objection to being called a man: far from it; but after years of being called a gentleman it was startling. This happened at Yokohama; and when, in the Customs House at San Francisco, a porter wheeling a truck broke through a queue of us waiting to obtain our quittances, with the careless warning, "Out of the way, fellers!" I knew that here was democracy indeed.
But I like it. I like the tradition which, once your name is written in the hotel reception book, makes you instantly "Mr. Lucas" to every one in the place. There is a friendliness about it: the hotel is more of a home, or at any rate, less of a barrack, because of it. And yet this universal camaraderie has some odd lapses into formality. The members of clubs in America are far more ceremonious with each other than we are in England. In English clubs the prefix "Mr." is a solecism, but in American clubs I have watched quite old friends and associates whose greetings have been marked almost by pomposity and certainly by ritual. Yet Americans, I should say, are heartier than we; more happy to be with each other; less critical and exacting. They certainly spend less time in discussing each other's foibles. That may be because the dollar is so much more an absorbing theme, but more likely it is because America is a democracy, and the theory of democracy, as I understand it, is to assume that every man is a good fellow until the reverse is proved. I should not like to say that the theory of those of us who live under a monarchy is the opposite, but it seemed to me that Americans are more ready than we to be sociable and tolerant.
Try as I might I could never be quick enough to get in first with that delightful American greeting, "Pleased to meet you," or "Glad to know you, Mr. Lucas." I pondered long on the best retort and at last formulated this, but never dared to use it for fear that its genuineness might be suspected: "I shall be sorry when we have to part."


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text:
Appeal Court faults 'overzealous' PAC
MASERU – The Public Accounts Committee (PAC) overstepped its mandate when it looked into individual complaints about estates handled by the Master of the High Court, the Appeal Court of Lesotho has ruled.
This the Appeal Court said in a judgment where the Committee had appealed a judgment in which the High Court had similarly found the PAC to have acted outside its mandate and powers when it interrogated specific financial affairs of the Office of the Master of High Court in 2018. Three employees of the Office of the Master of the High Court, 'Matahleho Matiea, Hlahlobo Morori and Moroesi Tau-Thabane (executor) had in 2018 complained about the conduct of the PAC when they were summoned for questioning before the Committee.
They were questioned in relation to a complaint received from one Mpho Mapetla who protested the manner in which the Master of the High Court handled her late father's estate. In the petition before the High Court Matiea challenged, in an affidavit, the manner in which the parliamentary committee conducted itself in questioning her, where she says she was "criticised extensively that she serves members of the public badly while also being unfairly criticised without being allowed to give her side of the story." Matiea said there were also threats of intimidation that suggested she could be handcuffed and arrested right on the spot.
She said her appearance before the PAC was "utter violation" of the administration of the estates proclamation and "this was notwithstanding the fact that some of the cases complained of were still pending before the courts of law." "I wish to take the court into my confidence and assert that the PAC was the judge, the complainants' representative and the prosecutor at the same time for all the cases," she said. Matiea and company complained that they were questioned in a degrading manner by the PAC members and that "in terms of the law, interrogation of financials and accounts of private citizens under custodianship of the institution of the Master of the High Court falls outside the powers of the PAC."
High Court judge, Justice Tšeliso Monapathi, agreed with them in his judgment delivered in March 2019 prompting the PAC to appeal the decision. In his judgment, Justice Monapathi said PAC's constitutional mandate was limited to investigating public funds and that monies belonging to specific agents were private monies that the Committee should not investigate. However, the judge did not fault the PAC in its manner and line of questioning.
The parliamentary committee then appealed justice Monapathi's judgment on at least the following grounds, that: the High Court erred and misdirected itself in holding that the PAC had acted ultra vires its constitutional power by investigating the financial affairs of the deceased estates governed by the Master of the High Court; that the High Court also erred and misdirected itself by holding that complainants in the High Court had locus standi (legal right) to seek an interdict and a declaratory on behalf of the Office of the Master of the High Court.
Also, the PAC had argued that the High Court did not have jurisdiction to hear the case, saying "the court a quo erred and misdirected itself by holding that it had jurisdiction to intervene in the unfinished proceedings of parliament." On top of that, the Committee maintained the High Court had no power to intervene in unfinished parliament proceedings and that the deceased estates are public funds as defined in the Public Financial Management and Accountability Act of 2011 arguing that they are empowered to consider financial affairs of all government organs, ministries and departments, as well as oversight over them.
To support their argument, they cited the National Assembly Standing Order 97 (5) which states "the Committee shall consider the financial statements and accounts of all government ministries and departments, executive organs of state, courts, authorities and commissions established by the Constitution and of each of the two Houses of Parliament; consider any audit reports issued on the financial statement, accounts or reports referred to the committee by the House…" A bench of five appeal court judges last Friday dismissed PAC's submissions saying while it is empowered to oversee finances of government ministries and departments as well as executive organs of state, investigation of the handling of a particular estate for which executors have been appointed was something else.
The court said PAC should be able to distinguish between concerns about irregular spending, mismanagement or corruption in the office and probing into handling of a private estate based on an individual complaint. "Naturally, in view of the oversight function of the PAC, it should be able to investigate concerns about irregular spending, mismanagement or corruption in the office of the Master of High Court or elsewhere in the state machinery…"
The court further stated "this, however, differs from using a hearing by the PAC to probe into handling of a private estate based on an individual complaint. The High Court has a role to play…" The judgment further states that the fact that the Auditor General may audit and that the PAC may investigates the financial affairs of the High Court (example) does not mean that they may probe into specific dispute between parties before it.
President of the Appeal Court, Dr Kananelo Mosito, handed the judgment that dismissed the appeal with costs. He determined the case with acting judges of the Appeal Court Petrus Damaseb, Phillip Musonda, Moses Chinhengo and Van Der Westhuizen. The judges warned about employees of the Office of the Master of High Court who they said were often engaged in corruption and malpractices in many countries.
"It must also be added that the Master's office and its officials should not be allowed to avoid having to respond to queries. Corruption and similar malpractices in this office in various countries have caused considerable financial loss and chaos," reads the judgment in part. The judges also found that employees of the Master of the High Court had the locus standi (legal right to sue) to have approached the High Court seeking the relief they sought against the PAC submission that they had no locus standi when they sued in their personal capacity.
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