This is an apartment located in Gran Via de les Corts Catalanes near Rocaford in the heart of Eixample, the central district of Barcelona. This apartment for students in Barcelona has 200m2 and consists of 10 student rooms -1 of them is shared- and perhaps what is most surprising of the apartment are the very high ceilings and the bright spaces due to a lot of exterior windows in the common areas of the apartment and also in each student room.
When all the rooms of this apartment are occupied you can find a total of 10 students. You can also relax yourself in your private student room in Barcelona since all rooms are really calm because are far from the common areas such as the living room and the kitchen.
Once you get into the apartment, you can notice a big hall connected to a huge living and dining room where you can share your meals with the rest of the students while looking through the window or staring at the balcony facing to one of the main streets of Barcelona. Next the dining room, you can find a fully equipped kitchen where you can even take a fast meal on its little table. In the kitchen, you will also find the washing machine and the dryer but the clothesline is on the large corridor between the student rooms. There are also 2 complete bathrooms, one with a bathtub and the other one with a shower.
Your own furnished room and the use of all furnished & equipped common areas. 50€/month for costs of supplies: water, electricity, gas, home insurance and community expenses. Unlimited use of internet WIFI.
Room pack (Bed Clothes, Duvet and Pillows).Bath pack (Pair of Towels). Advantages (discounts for activities, discos, …).
You will need to pay a deposit equal to a rental month. It will never cover a rental month. The payment of this deposit is the proof of your reservation. This deposit will be back to you at the end of your stay if there is no damage on the apartment and no rules were broken during your stay. On the day of arrival, in the event that we do not receive the 1st month rental payment, the company reserves the right to cancel your reservation without refunding the deposit.
Cancellations of confirmed reservations at least one month before the date of arrival, will be charged with 200 € penalization.
Our Team is available for you by social networks, phone and email or personaly if you require.
You can have visits during the daily hours (09:00 to 22:00h). You will always be responsible of the behaviour of your visitors and the damages that they can cause.
How much do you need to pay if you arrive: Between the 1st and the 10th day of each month, you will need to pay the complete month.
Between the 11th or the 20th day of each month, we will discount you 20% of your rent for the first month.
The 21st or later, you will pay per day. The price depends on the room you choose.
And if you leave: Between the 1st and the 9th day of each month, you will pay per day. The price depends on the room you choose.
Between the 10th and the 19th day of each month, we will discount you 20% of your rent for the last month.
The 20th or later, you will need to pay the complete month.
Check out will be scheduled one month before of your departure.


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Just bought an E3D V6 Hotend and Bondtech Extruder (both 1.75mm) for my Ultimaker 2 Extended.
Already did the hardware swap, but now I need to alter the firmware which is not my strong suit.
Does anyone know of a "how to" regarding the firmware?
It's going to be easier to make this upgrade if you use the same temp sensor from the stock hot end.
The UM2 uses a PT100 sensor. The E3D uses a 100k thermistor cartridge.
The electronics are setup for the PT100, so switching to the thermistor will be a bit of a pain.
The OD on the PT100 and the cartridge should be close. If they aren't the same, are you able to drill out the heater block to accomodate the PT100?
If it's too big, the grub screw can be used to pinch it against the heater block.
From there, the firmware changes are pretty easy.
Let us know when you get there and we can go to the next steps.
Perfect! No more error and I have everything downloaded.
Also, am I correct in assuming you meant the configuration.h file when you instructed to download the uncompiled FW?
It's going to be all of the files in the repository. Configuration.h is the one file you'll actually edit, but you need all the other files as well to compile and upload the firmware. The .ino file is the Arduino file which you would use to open the firmware in the Arduino IDE.
Ok I have all files downloaded.
Ok. Open Marlin.ino in Arduino.
You're looking for the line "#define heater_0_maxtemp"
You need to change the value for E0 for the Bondtech steps/mm. You will likely need to use the default value from Bondtech, and then measure it and adjust to get the exact value.
Once you've done that, go to Tools > Board, and select the Arduino Mega 2560. Then Tools> Serial Port, and select the port your printer is connected to.
Ok great thanks! I had the printer on, plugged in via USB, MatterControl / Cura off, and uploaded the FW - everything went as planned.
No errors and everything seems to be working fine, except I'm concern about the print head crashing into the front rail. I don't remember this happening prior to the hot-end swap.
@cope413, I adjusted the following and it corrected kept my hot-end from colliding with the rails. The hot-end now stops at the appropriate limits.
***Do I need to correct any other values such as the PID values referenced in the E3D wiki?
You don't *need* to if the temp stays stable at the target.
You can change them to the default values on the wiki, or you can run a PID autotune to get exact values for your machine/setup.
This will run the PID autotuning for 250C. You can tune to any temp you'd like - 250 is good because it's in the middle of the average functional range for 95% of filaments (200-300C).
When it's finished, it will spit out Kp, Ki, and Kd constants. You don't need to flash new firmware to enter these - they can be changed via EEPROM. You can access EEPROM through the Options tab in MatterControl.
Enter them in the appropriate spots and be sure to save it.
Thank you guys so much! I'm so excited to get back to printing - now with faster speed and better resolution!


text:
Everyone Loves A VW Camper Van
Everybody loves a VW camper van – it conjures up the joie-de-vivre of life eliciting images of sunny fields, carefree persona and a devil-may-care attitude to life.
VW love has endured for many a decade and the reasons for this are tenfold. The sense of freedom that a VW evokes – playfulness, holidays, the great outdoors, living closer to nature, drinking chilled rosé in a sunny field by the van, holidays with your favourite pet, life out on a limb, bucking the trend…. we could go on.
Campervans are about life on the road, going off the beaten track, making home where you find it and being spontaneous. This feeling of adventure, which the camper van awakens, explains the human races' long-held love and fascination with this manoeuvering, metal home.
The inception of the beloved VW camper van was back in 1947, thanks to a Dutch importer named Ben Pon. Pon observed, whilst traversing the floors of the VW factory, that motorized trollies, which had been built by staff to make the transport of parts around the factory easier, were a type of vehicle that had never been seen before. Inspired by this Pon did a rough sketch of the secret and sassy vehicle – a box-shaped truck-of-sorts with forward control and a rear engine. He did not rest on his laurels following his first sighting and sketching. His persistence to take this further eventually lead to him convincing engineer Heinrich Nordhoff to design a prototype of the wagon.
The first model of this new vehicle was unveiled in secret and quickly earned the nickname 'Bulli', which in German refers to its somewhat hulking and sturdy appearance.
Indeed, the VW camper is a solid piece of German engineering and in the first models the engine had a capacity of 1131 ccm, and an output of 18 kW at 3300 rpm. Current models vary greatly in both capacity and price and you can find every variety to suit your personal style. Many come with the full spectrum of cooker, bed, fridge, even loo and shower – yes we can enjoy living in our camper vans for weeks at a time now!
But just a little more history…
Between 1949 and 1967 Volkswagen created the first of many forms of the VW in a version cutely named a 'Splittie' due to the split windscreen. In 1951 the Westfalia was introduced. This was named after the contractor who built the vans Westfalia-Werke. The company was based in the Westphalia region of Germany. The Tipsy Pigs' sensational van is a Westfalia original – no copies or fakes for us! Registered in 1979 the Tipsy was imported to the UK in 2007 and has found its resting place at the auspices of Tipsy Pigs.
Lovingly restored to make way for a plethora of cocktails and fun the Tipsy is the surefire way to elevate your wedding, celebration party or corporate event to a new level of cultivated hipness. This is because Tipsy is run by people with a sense of fun, passion and commitment to pleasure, food perfection and a right, rollicking good time. We are all night party people and absolutely get what makes an event sparkle and fizz.
When we set up Tipsy Pigs we found inspiration in the sense of freedom and joy that a VW campervan inspires. We want to bring that celebration of life to your event. Tipsy currently has a stunning blue canopy over its frame and if you want to savour some of the Tipsy awesomeness at your event whether it be a celebration or promotion, we can work with you to create a canopy that reflects your brand or you. We can create a stunning showpiece for your occasion where guests can feast on cocktails, free-range gourmet meats or vegan delights and an array of gorgeous wines and spirits that match your palate.
Tipsy has already been on the road over the summer months visiting weddings and festivals including the Summer Night Film Festival, which is a festival of film set in beautiful heritage locations in the UK. The Tipsy went down a storm and everyone had a wonderful time. Our mission is to bring the spirit of the VW to all the best parties in the UK – to keep the history alive and to make sure the people we engage with – and hopefully that's you – share our spirit of adventure and have the same passion for VWs and amazing food and drink.
The beauty of the Westfalia original Tipsy Pig van is that it has a real history and has been adopted by our team of passionate creatives to offer something both inspirational and fun. We don't just inject diesel into our van – we inject a huge dose of fun and high-spirited professionalism to ensure that every event we are part of is a huge success.
By The Tipsy Pigs Admin|2020-08-17T13:08:01+00:00September 13th, 2016|0 Comments
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About the Author: The Tipsy Pigs Admin
The Tipsy Pigs was launched by Neil, Carla & James. After attending Fullbrook School in the 90's we went separate ways in the catering & events industry. In 2014 we had a brain wave to buy an old VW Campervan without much idea what to do with it but The Tipsy Pigs were born.
The Tipsy Pigs Provide Free Food for NHS Staff: Surrey Drive
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redpajama_set_name: RedPajamaCommonCrawl


text:
Onthophagus wigmungan é uma espécie de inseto do género Onthophagus, família Scarabaeidae, ordem Coleoptera.

Foi descrita cientificamente por Matthews em 1972.

Referências

Ligações externas

wigmungan
Coleópteros descritos em 1972

redpajama_set_name: RedPajamaWikipedia


When borrowing items from the library, please show your library card or photo ID (i.e. driver's license). Parents or legal guardians may show ID to borrow on a child's card, but not on a spouse's card.
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The library has joined the Missouri Department of Conservation "Rod and Reel Loaner" program. The mission of this program is to put rods and reels into the hands of library patrons - Missouri residents - and encourage them to get out and fish. Perhaps a family can't afford fishing gear for the entire family. This program allows patrons to check out rods through the library with hooks, sinkers and related tackle.
You are welcome to place unlimited holds on circulating items. Items are held for seven days once the hold is available for pickup.
The Poplar Bluff Municipal Library operates on the principle that our patrons can be trusted to return materials in a timely manner. Currently, we do not charge fines for overdue materials. Any overdue fines accrued up to the implementation of this policy are forgiven.
Library cards are blocked from checking out additional items if there are current overdue materials on the account or if there is money owed for lost or damaged items including processing fees.
If an item is not returned within forty-five days of becoming overdue, it is considered lost. The library card account will be charged for the full replacement cost of the item plus a $10 nonrefundable processing fee. Library accounts with items more than sixty days past due will be sent to collections. Lost items will be removed from the library catalog after six months, but all charges pertaining to the lost item will remain on the library card account.
Some items returned after the forty-five day period may be accepted at the discretion of the library. Should the returned item be accepted, the lost materials charge will be refunded via check. If the item is returned after having been billed and/or deleted, and is deemed acceptable, the library will simply void the replacement cost bill. In either case, the processing fee will remain and must be paid.
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Library WiFi is free and unlimited during normal business hours.
To use our WiFi, navigate to your devices WiFi Settings. Under availble connections you should see "Library Wi-Fi". Tap or click to connect. You will be asked to sign in. Open up a browser and our Acceptable Use Policy will be displayed. At the bottom of the page, tap or click to "Continue to Internet".
If you need help getting connected, staff at the main desk will be glad to assist you and make sure your are connected to our WiFi.
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The library offers many computer classes, which you can find by visitng the Computer Classes page.
Send or upload documents, emails and other files to the Library for printing through our Mobile Print service. Prints are 20¢/page for black & white and 50¢/page for color.


text:
Systemic effect of catumaxomab in a patient with metastasized colorectal cancer: a case report
Angelika Bezan1,
Florian Hohla1,
Thomas Meissnitzer2 &
Richard Greil1
Catumaxomab, the first anti-EpCAM antibody, was approved in 2009 for the treatment of malignant ascites in cancer patients with EpCAM positive tumors. We consider this case of interest as treatment with catumaxomab not only prolonged the puncture-free interval but also showed a systemic effect in a patient with metastasized colorectal cancer by regression of a pulmonary metastasis.
We describe the case of a 78 year old patient initially diagnosed with locally advanced colon cancer and one synchronous liver metastasis in September 2010 who was treated by hemicolectomy and simultaneous atypical liver resection. During adjuvant chemotherapy the patient developed a peritoneal carcinomatosis with ascites in March 2011. Palliative chemotherapy was not well tolerated and therefore refused by the patient. Because of disease progression in June 2011 with one pulmonary metastasis and clinically predominant ascites an immunotherapy with intraperitoneal catumaxomab was started in December 2011. After treatment with catumaxomab a puncture free survival of 12 months as well as a regression of the pulmonary lesion was achieved until January 2013.
This case suggests that treatment with catumaxomab does not only improve quality of life by local suppression of malignant ascites but also might have a systemic antitumor effect.
Metachronous peritoneal carcinomatosis (PC) has been reported in 4-12% of patients with colorectal cancer (CRC) [1]. According to the EVOCAPE 1 study median overall survival for patients with PC from CRC is 6.9 months, depending on TNM stage, size and distribution of peritoneal nodules and the presence of ascites [2]. Modern systemic chemotherapy as well as cytoreductive surgery and hyperthermic intraperitoneal (i.p.) chemotherapy are current treatment options for selected patients to prolong overall survival [3]. Malignant ascites, which is caused by the intraperitoneal spread of tumor cells, has an immense impact on the quality of life due to its symptoms and frequent recurrence [4]. Peritoneal tumor cells of CRC origin frequently overexpress the epithelial cell-adhesion molecule (EpCAM) [5]. Catumaxomab, which has been approved for the treatment of malignant ascites [6], has antigen-binding sites to epithelial tumor cells via EpCAM and to T-cells via CD3. With the Fc domain catumaxomab activates accessory cells resulting in a pro-inflammatory response leading to an immunologic antitumor effect [7].
We report on a 78 years old patient with peritoneal and pulmonary metastasized CRC. We consider this case of interest as treatment with i.p. Infusions of catumaxomab not only prolonged the puncture-free interval but also showed a systemic effect by regression of a pulmonary metastasis.
In September 2010 a 78 years old man was diagnosed with an adenocarcinoma of the right-sided colon. Initial staging by abdominal and pulmonary CT revealed a lesion in the right-sided colon penetrating the visceral peritoneum with infiltration of the abdominal wall (cT4b) and a single metastatic lesion in the liver, in segment VII, with a diameter of 1.5 cm (M1a) according to a stage IVA disease.
After right-sided hemicolectomy together with a simultaneous atypical resection of the single liver metastasis adjuvant chemotherapy (CTX) with capecitabine and oxaliplatin was started. After 5 cycles of adjuvant CTX the patient complained about a considerable increase of his abdominal girth. An abdominal CT in March 2011 yielded peritoneal nodules and ascites (Figure 1).
Contrast-enhanced computed tomography scan of the abdomen showing ascites (big arrow) and peritoneal nodules (small arrows) in March 2011.
After confirmation of a mutated K-RAS gene a palliative first line CTX with capecitabine and irinotecan in combination with bevacizumab was started. However, treatment was interrupted right after the first cycle because of an episode with neutropenic fever and resumption of CTX was refused by the patient until June 2011.
CT imaging in June 2011 showed a disease progression with a new solitary pulmonary lesion with a diameter of 3.3 × 2.8 cm (Figure 2a) and ascites in all 4 quadrants of the abdomen (Figure 2b). As the patient refused biopsy of the pulmonary lesion and the radiology report stated that the lung lesion was radiological consistent with a pulmonary metastasis a biopsy was not performed. Tumor markers CEA and CA 19.9 were within normal range at the time of diagnosis and during the whole course of disease. Clinically, the amount of ascites was increasing and required abdominal punctures on a weekly basis. Therefore the first line CTX with capecitabine, irinotecan and bevacizumab was reinitiated. Despite administration of granulocyte colony stimulation factor another episode of neutropenic fever occurred and CTX was discontinued after a total of 3 cycles in August 2011. As the patient refused to receive any further CTX and because of ascites being the predominant clinical symptom an immunotherapy with i.p. catumaxomab was started in December 2011 (4 consecutive i.p. infusions of catumaxomab on days 0, 3, 7 and 10 at increasing doses of 10, 20, 50 and 150 μg). Treatment was well tolerated without any side effects. Surveillance by CT scan in April, July and October 2012 showed a partial response of the pulmonary lesion and no paracentesis was necessary until January 2013 (Figure 3a and b). While the pulmonary lesion showed a further regression in size and could finally only be detected as a scar (Figure 4a), a CT scan in January 2013 showed a progressive peritoneal disease with ascites and a consecutive hydronephrosis III° of the right kidney (Figure 4b). As the patient still refused any further CTX we decided to restart i.p. treatment with catumaxomab in January 2013.
Contrast-enhanced computed tomography scan of the chest and abdomen showing disease progression in June 2011. (a) A 3.3 × 2.8 cm mass (big arrow) in the left lung and (b) ascites in all 4 quadrants of the abdomen (big arrow) and peritoneal nodules (small arrows).
Contrast-enhanced computed tomography scan of the chest and abdomen after treatment with catumaxomab in July 2012. (a) Partial response of the pulmonary lesion (1.8 × 1.1 cm, big arrow) and (b) regression of peritoneal carcinomatosis (small arrows) with less amount of ascites.
Contrast-enhanced computed tomography scan of the chest and abdomen in January 2013. (a) The pulmonary lesion can only be detected as a scar (big arrow). (b) Recurrent ascites (big arrows) and peritoneal nodules (small arrows).
Peritoneal carcinomatosis (PC) is one manifestation of metastatic CRC and is associated with a poor prognosis [3]. Few studies have been published describing the effectiveness of systemic chemotherapy in patients with PC. The results invariably show a disappointing response to systemic treatment and a poor prognosis compared to other metastatic sites [2, 3]. CRC frequently overexpresses EpCAM [5]. Overexpression of EpCAM has been associated with dismal prognosis in other tumor entities, such as gallbladder cancer, ovarian cancer and pancreatic cancer [8–10]. Catumaxomab, the first anti-EpCAM antibody, was approved in 2009 for the treatment of malignant ascites in cancer patients with EpCAM positive tumors [6]. This prospective randomized phase II/III trial showed a significantly prolonged median puncture free survival with catumaxomab (46 days) compared to paracentesis alone (11 days) in the pooled population. Although the study was not powered to detect a difference in overall survival, OS showed a positive trend for the catumaxomab group and was significantly prolonged in patients with gastric cancer patients compared to paracentesis alone (71 versus 44 days;p = 0.0313). Interestingely, in our case report treatment with catumaxomab not only extended puncture free survival by 12 months but also caused a regression of the pulmonary metastasis suggesting a possible systemic effect. So far an extraperitoneal effect of catumaxomab has never been described in a patient with colorectal cancer and was reported for a patient with ovarian cancer and breast cancer [11, 12]. A possible explanation for this systemic effect on tumor cells might be that catumaxomab is absorbed by lymphatics in the peritoneum and reaches the circulation. Low systemic catumaxomab levels (<1%) could be measured after i.p. infusion in nine out of thirteen patients with a high observed inter-individual variability [13]. Thus, an inverse correlation between tumor burden and systemic antibody bioavailability of catumaxomab was demonstrated in patients and in a defined mouse model [13]. The bioavailability of catumaxomab significantly declined in mice with higher tumor load. In the pivotal trial of Heiss et al. efficacy of catumaxomab was higher in patients without metastasis compared to patients with higher metastasis [6]. Therefore, in our patient a lower tumor burden might have resulted in higher plasma levels of catumaxomab. As blood samples have not been taken this determinant remains speculative. Furthermore an induction of anti-tumor specific T-lymphocytes that has been described after intraperitoneal administration of catumaxomab might be causative for its antiproliferative effect on distant metastasis [14]. Thus, in 5 out of 9 patients intraperitoneal administration of trifunctional antibodies such as catumaxomab induced a significant increase of tumor reactive CD4+/CD8+ T-lymphocytes with a prolonged survival. As catumaxomab is a nonhumanized chimeric antibody derived from mouse/rat IgG it is immunogenic when administered to humans. Thus, the development of human antimouse antibodies (HAMAs), which are associated with beneficial humoral effects and prolonged survival, could be detected in up to 95% of patients treated with catumaxomab [6]. In a post hoc analysis the correlation between the detection of HAMAS and clinical outcome was analyzed [15]. Patients who developed HAMAs after catumaxomab showed significant improvement in puncture-free survival, time to next puncture and OS [15]. Unaware of the impressive clinical outcome, no blood samples were taken from our patient in order to detect HAMAs. In the study of Heiss et al. the primary study objective was puncture free survival. Additionally the number of intraperitoneal tumor cells was counted before and after intraperitoneal administration of catumaxomab but no imaging method was used to assess the response to catumaxomab [6]. In the randomized phase IIa study by Baumann et al., response to catumaxomab in patients with platinum-resistant or –refractory epithelial ovarian cancer was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines for the first time [16]. The study revealed that catumaxomab had only modest activity in platinum-resistant ovarian cancer with an overall response rate of 28% in the high- dose treatment arm (10,20,50 and 100 μg) compared to 5% in the low-dose group (10,10,10 and 10 μg) on days 0,3,7 and 10.
Taken together, our observation suggests that catumaxomab might have a relevant systemic effect on cancer cells and therefore might improve the prognosis of patients with EpCAM-positive tumors. Further investigations to prove and to further explain this systemic effect of catumaxomab are warranted.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the editor of this journal.
CRC:
Peritoneal carcinomatosis
i.p.:
intraperitoneal
CTX:
HAMAs:
Human antimouse antibodies.
Koppe MJ, Boerman OC, Oyen WJ, Bleichrodt RP: Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies. Ann Surg. 2006, 243 (2): 212-222. 10.1097/01.sla.0000197702.46394.16.
Sadeghi B, Arvieux C, Glehen O, Beaujard AC, Rivoire M, Baulieux J, Fontaumard E, Brachet A, Caillot JL, Faure JL, et al: Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study. Cancer. 2000, 88 (2): 358-363. 10.1002/(SICI)1097-0142(20000115)88:2<358::AID-CNCR16>3.0.CO;2-O.
Klaver YL, Lemmens VE, Nienhuijs SW, Luyer MD, de Hingh IH: Peritoneal carcinomatosis of colorectal origin: incidence, prognosis and treatment options. World J Gastroenterol. 2012, 18 (39): 5489-5494. 10.3748/wjg.v18.i39.5489.
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Spizzo G, Fong D, Wurm M, Ensinger C, Obrist P, Hofer C, Mazzoleni G, Gastl G, Went P: EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis. J Clin Pathol. 2011, 64 (5): 415-420. 10.1136/jcp.2011.090274.
Heiss MM, Murawa P, Koralewski P, Kutarska E, Kolesnik OO, Ivanchenko VV, Dudnichenko AS, Aleknaviciene B, Razbadauskas A, Gore M, et al: The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial. Int J Cancer. 2010, 127 (9): 2209-2221. 10.1002/ijc.25423.
Ruf P, Lindhofer H: Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody. Blood. 2001, 98 (8): 2526-2534. 10.1182/blood.V98.8.2526.
Fong D, Steurer M, Obrist P, Barbieri V, Margreiter R, Amberger A, Laimer K, Gastl G, Tzankov A, Spizzo G: Ep-CAM expression in pancreatic and ampullary carcinomas: frequency and prognostic relevance. J Clin Pathol. 2008, 61 (1): 31-35.
Spizzo G, Went P, Dirnhofer S, Obrist P, Moch H, Baeuerle PA, Mueller-Holzner E, Marth C, Gastl G, Zeimet AG: Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer. Gynecol Oncol. 2006, 103 (2): 483-488. 10.1016/j.ygyno.2006.03.035.
Varga M, Obrist P, Schneeberger S, Muhlmann G, Felgel-Farnholz C, Fong D, Zitt M, Brunhuber T, Schafer G, Gastl G, et al: Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival. Clin Cancer Res. 2004, 10 (9): 3131-3136. 10.1158/1078-0432.CCR-03-0528.
Petrelli F, Borgonovo K, Lonati V, Elia S, Barni S: Regression of liver metastases after treatment with intraperitoneal catumaxomab for malignant ascites due to breast cancer. Target Oncol. 2013, 8 (4): 291-294. 10.1007/s11523-012-0240-y.
Woopen H, Pietzner K, Darb-Esfahani S, Oskay-Oezcelik G, Sehouli J: Extraperitoneal response to intraperitoneal immunotherapy with catumaxomab in a patient with cutaneous lymphangiosis carcinomatosa from ovarian cancer: a case report and review of the literature. Med Oncol. 2012, 29 (5): 3416-3420. 10.1007/s12032-012-0285-x.
Ruf P, Kluge M, Jager M, Burges A, Volovat C, Heiss MM, Hess J, Wimberger P, Brandt B, Lindhofer H: Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients. Br J Clin Pharmacol. 2010, 69 (6): 617-625. 10.1111/j.1365-2125.2010.03635.x.
Strohlein MA, Siegel R, Jager M, Lindhofer H, Jauch KW, Heiss MM: Induction of anti-tumor immunity by trifunctional antibodies in patients with peritoneal carcinomatosis. J Exp Clin Cancer Res. 2009, 28: 18-10.1186/1756-9966-28-18.
Ott MG, Marme F, Moldenhauer G, Lindhofer H, Hennig M, Spannagl R, Essing MM, Linke R, Seimetz D: Humoral response to catumaxomab correlates with clinical outcome: results of the pivotal phase II/III study in patients with malignant ascites. Int J Cancer. 2012, 130 (9): 2195-2203. 10.1002/ijc.26258.
Baumann K, Pfisterer J, Wimberger P, Burchardi N, Kurzeder C, du Bois A, Loibl S, Sehouli J, Huober J, Schmalfeldt B, et al: Intraperitoneal treatment with the trifunctional bispecific antibody Catumaxomab in patients with platinum-resistant epithelial ovarian cancer: a phase IIa study of the AGO study group. Gynecol Oncol. 2011, 123 (1): 27-32. 10.1016/j.ygyno.2011.06.004.
Pre-publication history
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/13/618/prepub
IIIrd Medical Department with Hematology, Medical Oncology, Hemostaseology, Rheumatology and Infectiology, Paracelsus Medical University of Salzburg, Müllner Hauptstrasse 48, 5020, Salzburg, Austria
Angelika Bezan, Florian Hohla & Richard Greil
Institute of Radiology, Paracelsus Medical University of Salzburg, Müllner Hauptstrasse 48, 5020, Salzburg, Austria
Thomas Meissnitzer
Angelika Bezan
Florian Hohla
Richard Greil
Correspondence to Florian Hohla.
AB, FH and RG wrote the paper. TM assessed response by reviewing patients imaging studies. All authors read and approved the final manuscript.
Authors' original submitted files for images
Below are the links to the authors' original submitted files for images.
Authors' original file for figure 1
Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Bezan, A., Hohla, F., Meissnitzer, T. et al. Systemic effect of catumaxomab in a patient with metastasized colorectal cancer: a case report. BMC Cancer 13, 618 (2013). https://doi.org/10.1186/1471-2407-13-618
DOI: https://doi.org/10.1186/1471-2407-13-618
Catumaxomab
Systemic effect
Ascites


text:
1909. је била проста година.

Догађаји

Јануар

 28. јануар — Америчке трупе су напустиле Кубу са изузетком базе Гвантанамо где су се налазили од краја Шпанско-америчког рата.

Фебруар

Март
 4. март — Вилијам Х. Тафт је инаугурисан за 27. председника САД.

Април
 6. април — Амерички истраживач Роберт Пери је освојио Северни пол, прешавши са експедицијом на санкама 1.600 km.
 14. април — Након војне побуне против владе, руља је започела масакре над Јерменима у вилајету Адана.

Мај

Јун

 10. јун — Први пут употребљен сигнал SOS када је линијски брод Славонија компаније Кјунард, доживео бродолом на Азорским острвима.

Јул

 25. јул — Француски пилот Луј Блерио је први авионом прелетео Ламанш.

Август

Септембар

 20. септембар — Парламент Уједињеног Краљевства је усвојио Акт о Јужној Африци из 1909., чиме је створена Јужноафричка Унија од бивших британских колонија Рт добре наде, Натал, Орање и Трансвал.

Септембар

Октобар

 24. октобар — Ракониђијска погодба

Новембар

Децембар

Непознат датум
 Википедија:Непознат датум — фебруар — објављен Манифест футуризма
 Википедија:Непознат датум — март — започет Велеиздајнички процес (1909)

Рођења

Јануар

 22. јануар — У Тант, бурмански политичар. (†1974)

Април

 22. април — Индро Монтанели, италијански новинар и историчар. (†2001)
 26. април — Анђа Ранковић, текстилна радница, учесница НОБ-а и народни херој († 1942)
 29. април — Том Јуел, амерички глумац. (†1994)

Мај

 14. мај — Светозар Радојчић, српски историчар уметности (†1978)
 26. мај — Адолфо Лопез Матеос, мексички политичар († 1969)
 27. мај — Хуан Висенте Перес Мора најстарији мушкарац на свету

Јун

 24. јун — Вилијам Џорџ Пени, енглески физичар и математичар († 1991)

Август

 27. август — Силвер Мас, белгијски бициклиста. (†1966).

Новембар
 5. новембар — Милена Павловић-Барили, српска сликарка († 1945)
 12. новембар — Перо Перовић, најстарији Црногорац. († 2015)
 28. новембар — Александар Ранковић, српски политичар. († 1983)

Смрти

Фебруар

 17. фебруар — Џеронимо, поглавица Апача

Септембар

 12. октобар — Франциско Ферер, каталонски слободарски педагог и оснивач покрета модерних школа. (*1859)

Нобелове награде
 Физика — Гуљелмо Маркони и Карл Фердинанд Браун
 Хемија — Вилхелм Оствалд
 Медицина — Емил Теодор Кохер
 Књижевност — Селма Лагерлеф
 Мир — Члан Међународног суда за арбитражу Огист Мари Франсоа Бернер (Белгија); Пол Балије д'Етурнел де Констан и барон Де Констан де Ребек (Француска)
 Економија — Награда у овој области почела је да се додељује 1969. године

1900-е
01909


4181 Fishing Creek Ln is a $255,990, 1,701 square foot, 3 bedroom, 2.0 bath home located in Middleburg, FL.
The avon floor plan in Azalea Ridge features pendant lights,granite counters, and stainless steel appliances. If you're looking for a neighborhood offering gorgeous homes and an abundance of fun recreational opportunities that bring a refreshing sense of community, look no further than Azalea Ridge, North Florida's exciting new single-family community in the heart of Clay County. Located in the Clay County school district, Azalea Ridge is also convenient to Jacksonville's Naval Air Station.
I am interested in 4181 Fishing Creek Ln, Middleburg, FL 32068.


text:
7th & Jackson Resiliency Park
This project would not have been possible without the partnership that was created between Bijou Properties and the City of Hoboken. Through collaboration with the City administration and the Redevelopment Subcommittee, a redevelopment plan was established which allowed the transfer of development rights from the two adjacent parcels (2 & 3) - which are now going to be parks and open space - to the lot which now contains the residential building (1). To be specific, Bijou Properties purchased two additional parcels each with its own as-of-right zoning. By transferring the development rights from those additional parcels 2 and 3 to the original parcel 1, Bijou was able to develop the two public parks. A comprehensive redevelopment agreement, which included tax incentives, was put in place that allowed the public portion of the project to be built without city dollars. This creative deal-making couldn't have happened without intense collaboration and cooperation between the developer and the City. 7 Seventy House realizes that this redevelopment area provides an opportunity to incorporate durable flood protection and resiliency, traffic calming measures, and improve pedestrian safety into the vision of its development. By incorporating stormwater detention systems underground, a variety of stairs, various seating levels, and rain gardens into the development, flooding levels will significantly and successfully recede, reduce the urban heat island effect, protect residents and businesses from unfair flood insurance, and protect the people and urban character of Hoboken.
Lenox & Quinn Padestrian Plaza
Seymour Street Redevelopment
Park Francis Pavonia Plaza
Marchetto Higgins Stieve
Contact@MhsArchitects.com
1225 Willow Ave
Hoboken, NJ 07030
© 2023 Marchetto Higgins Stieve, P.C.


CTRM is a term you are familiar with as a reader of our Blogs: Commodity Trading and Risk Management Systems. They are purpose-built software systems to automate complex and routine tasks and business processes around supply/sourcing management thereby eliminating manual processes and reducing costly errors. CTRM systems have been commercially available for almost two decades, yet firms still often find themselves using spreadsheets or developing systems in-house, believing those are better options for reasons of cost, strategy, and flexibility. Yet, they blind-sided themselves from a next-generation CTRM solution that offers all the non-proprietary functionality to support individual strategies with implementation options that can compete with the cost of playing 'software-house' internally: TRMTracker ("TRM") by Pioneer Solutions. Hence, an invitation to you 'See TRM' – an Eye Opener!
Real-time Visibility and Enhanced Decision Making: Increasing transparency across the enterprise from the portfolio manager to the chief risk officer.
Fewer Missed Deal Opportunities: Valuation and drill down reporting capability to view exposure to market, volumetric and other risk.
Centralized Control and Decentralized Execution: Stay agile with trader autonomy while enabling management control.
Minimize Disputed Settlements: Settle correctly and maximize operational margins and improve financial accuracy down to the cent.
Improved Hedging: Better information enables to hedge out further and reduce capital expenditures.
Operational Excellence: Protect your margins: Single system reduces risks and mistakes and therefore unnecessary added costs.
As a result, operational risks will be minimized, process efficiency increases, and you keep up with the industry regulations and standards.
When companies can configure their proprietary business processes and feed it or configure it with their 'secret sauce' that drives their strategy, then there is hardly a value-add for inhouse development.
When a modern CTRM system, such as TRMTracker, offers a high-degree of user configurability, the reliance on the vendor will reduce for a lower cost of ownership over time. TRMTracker allows the user to configure and change templates, formulas, book structures and data import/export rules supporting a slew of formats from flat files to XML, SOAP and REST webservice APIs. To minimize the future cost of maintaining customizations, the system allows, among others, to add user define fields. Finally, innovative reporting options offer easy report creation and ensures user adoption, should the intuitive screens haven't done that already.
Some of the Trends for 2018 that also applied to CTRM were Automation, Analytics and Cloud services. TRMTracker, conceived as a web-based system, was developed from the back-to-the-front, thereby ensuring it is has the leading backoffice functionality in the industry. As a result, end-to-end automation can be realized with a live system that offers in the front office robust and smart deal entry including market connections, updates positions in near real-time whether on the desktop or smart phone, utilizes rule-based algorithms, while the back-office benefits from straight-through-processing and functionality to settle standard and complex non-standard contracts. Consequently, it also supported digitization so that further forms of artificial intelligence can be applies, such as robotic process automation.
With these capabilities and features, TRMTracker also caters to the non-enterprise level companies that have grown out of their spreadsheets. Via www.TRMtracker.com, a self-serve, rapid deployment online CTRM service is offered, leveraging selected Tier-1 functionality for basic deal capture, position management, and standard reporting for mark-to-market and P&L. No hardware and software needed, just a browser to access the service via the internet. A compelling CTRM Software-as-a-Service to growing businesses who need a modern, agile business solution that is reduces their complexity and cost.
When customers tell you that your software has been an eye-opening solution for their business, you feel the urge to tell others and give them an opportunity to experience the same. Investing in a modern CTRM system will help not only surviving but succeeding in today's disruptive business world. Pioneer's offering is state-of-the-art, and we look forward hearing from you to See TRM with us.


Megan Kleine started swimming competitively in Lexington, Kentucky, where she attended Henry Clay High School. She then swam in college at the University of Texas. Morris swam the 100 breaststroke at the 1992 Olympics, making the B final, and swam in the prelims of the women's medley relay, which earned her a gold medal. She later married, becoming Megan Morris, and she and her husband settled in Houston, where she raised two daughters.


text:
Floater Quotes : Mfyi.com
Floater Quotes
I felt legitimized, because all the bands out there that were getting signed and getting press and doing world tours had a very uniform, homogenous sound. I like hard rock and metal, but I don't have a lot of tolerance for it. I think why we got embraced by a lot of those people is because they felt the same way I did. I like bands that don't have a cool factor. I mean, you can tell when it's camp, like the guitar-face guy and when it's Joe Cocker.
Robert Wynia
Well, we all were weaned on 4AD [the label behind the Cocteau Twins, Dead Can Dance, the Pixies, etc.] stuff. Dead Can Dance is always on the bus when we're out on tour. A lot of it has come from that influence. It's a strange recipe, because it seems like it works unbelievably well on a lot of levels on a lot of people, and it really doesn't work on a lot of people, too. Not a lot of gray area. I'm a bit baffled at why.
� Mfyi.com


text:
Research Scholarship
The Fremantle History Society has much pleasure in announcing a research scholarship to celebrate its 20th anniversary. The scholarship supports the Fremantle History Society's objectives and in particular encourages new research relating to Fremantle's history.
The scholarship is open to anyone interested in pursuing the highest level of research and writing and will require the completion of a written work, the format of which can be negotiated but will most likely take the form of a monograph of up to 10,000 words to be published by the Fremantle History Society.
Click below for details and for an application form. Applications close Friday 12 September 2014. The recipient of the scholarship will be announced at Fremantle Studies Day, Sunday 26 October 2014.
FINALFremantle History Society RESEARCH SCHOLARSHIP
Please forward applications to the Secretary at secretary.fhs@gmail.com
2014 MURDOCH LECTURE
CAPTURING THE ENEMY
Capturing the enemy – photo exhibition at Rottnest
Capturing the Enemy is a special heritage exhibition to be held in the Rottnest Island Salt Store from Anzac Day to mid-August.
This year marks the centenary of the commencement of World War One and Rottnest Island Authority is hosting an exhibition of photographs taken on Rottnest Island in 1914 and 1915 when it was an internment camp for enemy aliens. German and Austrian Slav (mainly Croatian) men and boys, held in the internment camp between August 1914 and November 1915 are shown in the familiar landscapes of the Island, along with Australian soldier guards and Aboriginal men, brought to the island as extra labour.
This exhibition runs daily from 25 April – 31 August, at the Salt store 10 – 3pm
Event – The Royal United Services Institute of Western Australia Inc
STUDIES IN WESTERN AUSTRALIAN HISTORY – Free Copies Available


AppKnitters Co. gives computerized shape to your ideas. Every one of our products is made with exactness and addresses all the customer's projections as well as users' needs.
From startups to multi-national enterprises, we work over an entire range of domain. However, the vast majority of our portfolio customers belong to one of these.
Let us help you make your idea a reality.
We care about customers privacy. Your information will be kept secret.


Ann and Sid Mashburn are design royalty without the pomp and circumstance. In 2007, they opened their first shop, Sid Mashburn, on Atlanta's Westside. That followed with their Ann Mashburn shop next door. In the time since they've launched stores in Dallas, Los Angeles, Washington D.C., and Houston. The pair opened their new lifestyle brick-and-mortar — Mashburn — in Atlanta, and invited the What's in Store team out to learn how they're using the email designer and segmentation to keep customers informed and build their e-commerce audience.
Their love story began in 1980s New York City. While Ann was working at Condé Nast as an assistant and editor at both Vogue and Glamour, Sid had various design stints at J.Crew, Ralph Lauren, Tommy Hilfiger, and Lands' End. Connected through their passion for style, design and retail, the Mashburns wanted to recreate the shop vibes they saw in Europe and Asia: stores where the customer experience was just as important (if not more) than the products being sold.
Along with the 7 men's and women's retail locations, and e-commerce sites at sidmashburn.com and annmashburn.com, the team opened a new concept space next to their 2 Atlanta flagship stores. The aptly named Mashburn has a little bit of everything: coffee bar, vinyl collection, home goods and their new kids line, Kid Mashburn. Whereas the Sid and Ann Mashburn stores are geared toward rare, classic finds for men and women respectively, the Mashburn space lends itself to the experience behind the name.
The Mashburns say that even with their expansion over the last decade, their marketing goals to build relationships with customers and drive traffic to their retail channels haven't changed. However, Sid says, though the idea is that eventually the Mashburn brand and moniker will stand as one unified name, they're very aware that they have predominantly different customer bases.
One campaign speaking to a specific audience is called "Wish You Were Here." This campaign series is sent out to online customers that live in cities that have physical stores. The emails encourage online shoppers to visit and interact with the Mashburn brand in person. "As much as we connect with people online, we feel like the stores bring that experience to life," Ann says.
Scottie Walden, who leads Mashburn's public relations and digital presence says the team has been able to segment their list based on geographic location as well as specific brand interests (Sid Mashburn, Ann Mashburn, Kid Mashburn), in order to deliver highly targeted messaging around events they're hosting in various cities.
While keeping all of their contacts in one main mailing list, the Mashburn team is able to use Mailchimp's segmentation tools to send personalized messages based on a contact's specific location, interests or preferences — or even target based on shoe size. The Mashburn team continues to use newsletters to communicate brand announcements, various offline events, and weekly updates on their website and stores.
"In the past 2 years, we have been much more active in using features to deliver more targeted messages to our customers and provide more of a personal touch than we have in the past," Scottie says.
Being intentional with the design and copy for their respective newsletters is something Ann and Sid take serious. Using the email designer, that message is delivered to their creative teams behind those different campaigns that are using the feature to easily drag and drop images and art that work best with the specific branch of the Mashburn brand.
Part of that maintaining that tone across all of their lines is a less straightforward approach than those of a lot of other retailers. For example, they'll use puns — in all caps — such as, "ARE YOU SATIN DOWN FOR THIS" for the launch of a limited-edition satin shoe, or "STEP INTO MY OFFICE" to announce new driving mocs. Why open rates for Mashburn's main mailing list consistently over the industry average?
Speak to customers using segmentation and groups.


text:
Multiple explosions target police in Kabul leaving at least 4 dead
Home WORLD NEWS Multiple explosions target police in Kabul leaving at least 4 dead
admin, December 26, 2020 December 26, 2020 , WORLD NEWS, 0
KABUL — A series of explosions hit Afghanistan's capital, Kabul, on Saturday, killing at least four police officers, officials said.
The deaths were caused by a sticky bomb attached to a police vehicle detonated in western Kabul, police spokesman Ferdaws Faramarz said. The explosion also wounded two civilians.
Two other police officers were wounded when a bomb attached to their car exploded earlier Saturday in southern Kabul, Faramarz added.
Maooma Jafari, deputy spokeswoman for the health ministry, said that four corpses and four wounded people were taken to hospital following the two explosions.
A third sticky bomb detonated in eastern Kabul but caused no casualties, he said.
There were reports of at least two other blasts elsewhere in the city but police had no immediate details.
Download the NBC News app for breaking news and politics
In a separate report form northern Balkh province, a senior army officer was killed when his vehicle hit a roadside bomb, said Arif Iqbali, a Sholgara district police chief.
Iqbali said that Mohammad Tareq, the garrison commander of the army brigade in Balkh was the apparent target, who was killed in the attack.
The latest attacks come as Taliban and Afghan government negotiators hold talks in Qatar, trying to hammer out a peace deal that could put an end to decades of war.
The talks in Doha have been suspended until early January, amid speculation they could be further delayed.
No one has immediately claimed responsibility for the attacks in Kabul.
Nov. 18, 202001:44
The Islamic State group has claimed responsibility for multiple attacks in the capital in recent months, including on educational institutions that killed 50 people, most of them students.
At the same time, Taliban militants have waged bitter battles against IS fighters, particularly in eastern Afghanistan, while continuing their insurgency against government forces and keeping their promise not to attack U.S. and NATO troops.
IS has also claimed responsibility for last week's rocket attacks targeting a major U.S. base in Afghanistan. There were no casualties.
Taiwan will not bow to China pressure, president says after Beijing reunification call
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Taiwan will not bow to pressure from Beijing and it will keep bolstering its defenses, its president said Sunday,...
Omicron is more vaccine resistant, causes milder illness in South Africa, study finds
The first major real-world study of the omicron Covid-19 variant found that it appeared to cause less severe illness...
'Savage act': Anger at Afghan government after 18 members of family feared killed in airstrike
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KABUL, Afghanistan — Mir Hatim says he spent the early hours of Jan. 10 sifting through the bombed-out house...
Italian police clash with demonstrators protesting country's new Covid-19 restrictions
Demonstrators hit the streets in Italy to protest against the country's new Covid-19 measures that impose restrictions on bars...
'Severe' Covid-19 cases surge in Tokyo during Olympics
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TOKYO — Japan's prime minister on Tuesday said there were no plans to shut down the ongoing Olympics Games...
Meghan says royal life caused suicidal thoughts, palace had 'concerns' about son's skin color
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Swimmer sacrificed his Olympic dream after brutal military coup
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Covid-19: Tougher Covid rules begin for millions in UKLakers reserves showcase the team's depth in win over Mavericks


Marine Le Pen is a highly controversial presidential candidate in the French elections which are set to take place on April 23rd, and according to her latest statements on Wednesday for RTL radio, if elected president, she will introduce the new Franc at a rate of 1-1 to the Euro and then it will allow it to float free/fluctuate.
It's interesting to note that Le Pen said previously that France's new currency will be the opposite of a free floating Franc, i.e. will be pegged to a basket of currencies.
According to her wishes, the Franc would most probably fall against the German currency, whatever that is, most probably the Euro. And a "cheaper" currency, i.e. the new Franc would make French exports like cars, wines and cheese (I am only kidding) more competitive. Also she believes that the Franc will rise against the currency in Italy, which momentarily uses the same Euro just like Germany and France, hinting that Italy too may leave the Eurozone in the future.
Even if Le Pen's statements from Wednesday may seem far fetched to many of you reading this article, incidentally Paddy Power agrees with Le Pen's predictions, offering even odds for Italy leaving the European Union before 2025, which is way higher than the odds of Greece leaving the EU and remember that Greece's economy is in shambles for years now.
Le Pen believes that leaving the Euro currency would be better off for France, as the country was doing great in terms of trade prior to joining the European Union. Le Pen is expected to win easily the first round of the presidential election and to lose categorically the second round on May 7th, with Macron (her Nemesis) credited to getting 61,5% of the votes.
However, we've already heard it all before from the mainstream media with Donald Trump, "he'll never win the primaries, he'll never be president" etc.


What Can Two-Way Radios Do? 8 Surprising Capabilities!
Highland Wireless: Providing In-Building Distributed Antenna Systems (DAS) > Blog > Blog > What Can Two-Way Radios Do For You? 8 Surprising Radio Capabilities!
What Can Two-Way Radios Do For You? 8 Surprising Radio Capabilities!
Two-way radio capabilities far surpass what many people realize offering a world of unexpected benefits and perks to businesses and individuals. As radio technology improves the benefits only keep getting better. Electronic chip sets grant GPS receivers their powers, and the technology behind these chips has greatly expanded within the last four-years. This means newer models include greater capabilities than ever before.
Cell phones might be the most modern form of communication but two-way radios remains the most dependable form of communication for businesses of all types and sizes. These sturdy suckers can certainly handle a punch, plus they are equipped to keep everyone in constant communication without the distractions presented by cell phones. When you switch to two-way radios the benefits are aplenty… here are 8 surprising benefits radio systems offer.
Many of the latest two-way radios include GPS capabilities that allow you to locate your team with one glance at the screen. This functionality also prevents team members from getting lost and wasting precious time on the clock. The options with GPS are endless and may benefit your business in many ways. This may also offer the opportunity to clock performance and uncover tricks to saving time and making more money.
Bluetooth is included on many of the leading two-way radios and offers a number of benefits. For one it allows hands-free communication, which is vital in some industries, for instance cab drivers that are required by law in certain states to talk hands free at all times while behind the wheel. Other hands-on industries don't have time to pick up a device to talk either, in which case the freedom of Bluetooth is very valuable.
In emergencies two-way radios remain the leading source of successful communication. When everyone is trying to use their cell phones at once the airwaves become blocked and calls stop going through. With your own two-way radio system you don't have to worry about this. Weather and other elements can also cause power outages and downed phone lines that cut off all forms of communication, unless you have a two-way radio.
Dropping a cell phone can easily be the end of a device but commercial two-way radios are a different beast entirely. Radios are made to stand up to the challenges of work out in any field. A construction site, for instance, isn't the place for a dainty little iPhone, hence why construction teams are almost always outfitted with two-way radios. There are a number of water and dirt-resistant radios, and almost all models are built to withstand a fair share of falls. Thanks to this durability you spend less money replacing devices and work environments chug along undaunted even if someone steps on their device or drops it in a puddle of water.
Two-way radios have only recently developed capabilities of conversing over a very long range. Most two-way radios operating on GMRS or Family Radio services typically only communicate across a few miles at most. All of that is changing with the latest Wide Area network capabilities offered by Highland Wireless. The latest developments in technology allow you to talk over 300 miles and it sounds like the person on the other end is right next-door.
Contact us to learn more about our Wide Area network.
Most people would agree that cell phones are very distracting. The last thing you want is to be distracted on the job, this can lead to unnecessary accidents and wasted time. Two-way radios don't offer access to apps, games, or social media meaning the distractions are axed out while reliable and easy to access communication remains.
Two-way radios don't just offer verbal lines of communication; they also allow you to send text messages as well. When working under discreet conditions this can be extremely useful, as well as countless other scenarios. Some two-way radios do not come with a screen; in this case text messaging is not an option. If this is a feature you want make sure to keep that in mind.
Two-way radios are far more affordable than other forms of communication. You can even rent radios for however long or short of time you may need them. You can supply every team member with a radio and service for the same price as one cell phone plan.
Highland Wireless offers the latest two-way radios, reliable service and repairs for one low monthly price. Contact us today to learn more.


Oh, and since this might be relavant soon, due to the *squee* upcoming series, what is your stance and fanmade music videos? (Commonly known as vidding).
I suppose fan fiction is also another way for impatient fans to try to get more of their chosen setting. Also I imagine in the growing times of instant gratification, fan fiction may be seen as a quick fix for the addicted. I am sure you are flattered by the desire but your points make an awful lot of sense. Maybe these fans need a sanctioned 'sandbox' to play in that is far from the garden but still has a lingering aroma about the place. It would be interesting to see if you just wrote two paragraphs on a location and let the fan ficts have at it. Just a thought.
A very well thought out argument, sir. When I became a fan of yours some years ago, I was at first really disappointed you didn't allow people to write fanfic of your 'verses, and since then I've always kind of wondered why. I won't lie and say it didn't affect my view of you to some degree.
But you present a very well thought out, reasonable argument, and for that, I thank you. It was enlightening. I still think you're wrong to not allow fanfic, but it's your position, and I respect it, and I hope other people respect it as well.
Thanks for writing this; it was really fine reading.
This post really interested me because I've been euphorically writing fanfiction for the last couple years, after looking down on it for most of my life. I had a borrowed-world story pop into my head and started writing it out on a whim, and was surprised by how much the exercise helped me develop skills I could use for my original fiction (which oh so desperately needs development).
I'd heard that my favorite author (one GRRM) didn't like it, and shrugged because I wasn't interested in borrowing Westeros anyway. If I had been, though, I never ever would have touched it without knowing if I had the creator's approval. Copyrights and food on the table aside, that's just crass, and it's not that hard to find out which worlds are sanctioned for public use.
The world I use is from a TV show, and its creator has openly encouraged fanfiction using his setting and characters. But even beyond that, the difference I see between doing what I'm doing and using A Song of Ice and Fire in fanfiction is the medium. The creative team that goes into making a single TV show is already pretty huge, and each character is already the child of many minds. Also, I already know that I can't offer visuals like TV does, and TV can't get into the minds of characters like the written word does, so the separation of the original work and the fan product is nice and clean. Anyone looking for profit this way is one lost puppy.
I'd be curious to hear what you think about the possibility of fanfiction being written for the HBO show. Don't get me wrong, I still wouldn't do it and I'd discourage anyone I know from doing it, but does it strike you as any different from directly ripping off your written work?
If the HBO show is a hit, I am sure it will generate reams and reams of fan fiction.
Whether HBO will encourage it, tolerate it, ignore it, or try to shut it down, I cannot say. That's their call.
For my part, I don't intend to read any of it, and I don't want anyone sending any of it to me.
Ahaha, I read the subject line and instantly thought "Wait, XKCD?" I didn't know you read it, that's awesome!
I wish to salute you...having written fanfic myself in the past, I was prepared to disagree with you. But your argument is valid, and has made me reconsider some things.
I never used another author's characters...only a world setting. I realize that this is in a sense, standing on the shoulders of giants, but I never considered myself a great writer. I was just having fun.
Do you think a clear legal disclaimer would be helpful, or no? Our fanfic site clearly stated "the works here are based on the world setting created by Author XYZ; everything is owned by him, none by us, no profit is made from this site and no profit will ever be made by us from the works created here". If the fanfic writers openly and clearly disavow any claim whatever on what they create, would this help to mitigate some of the potential for copyright infringement? Possibly not, from the way you described defense-of-copyright requirements (which, btw, I find ridiculous...it's like claiming that unless you open fire with a machinegun on every intruder to your home, people are free to call your house abandoned and take all your stuff).
The above question is not an attempt to change your mind; you made it clear your reasons are personal as well as legal/financial.
In closing, I've never written Ice and Fire fanfic, though I have played the excellent role-playing game by Green Ronin press...which involves a fair bit of collaborative storytelling. That's all fanfic ever was to me. A chance to take something awesome and tinker with it for a bit.
I think your novels are superb, and am eagerly awaiting the next.
You may find the concept ridiculous, and I don't disagree... but there's plenty of precedent for it in law, and not just copyright law. Consider easements, for instance. When we first bought our present house, the back yard was unfenced, and we soon discovered that kids from the houses back of us would cut through our yard on their way home from school to save having to go around the corner. Our attorney warned us, "Better put up a fence as soon as possible. If you don't, and this goes on long enough, you won't be allowed to put up a fence. The law will consider that, by tolerating the shortcut, you have created a public easement across your property."
I don't want any easements across my intellectual property.
Hm, it would be kinda interesting to compare this with that of the Japanese anime fandoms, where the authors pretty much turn a blind eye to fanworks created by their fans. But then the Japanese companies have a different way of looking this sort of thing.
Japan's copyright laws are much different than the United States' laws. Fan works (doujinshi) can be published in small runs and sold for a profit without risk of lawsuit, and without the original author/publisher losing their copyright privileges (most importantly in terms of anime and manga-the privilege to license those rights as they see fit for adaptations and merchandising). But, if you talk to most publishing houses and anime production studios, they generally dislike fan translations of the work into English, because that can interfere with their ability to license a work to an American distributor.
I definitely agree that an author's rights (whether it's of written fiction, graphical works, software, etc.) extend to controlling derivative works. They should be able to determine, based on their own comfort level and preference, where they want to draw the line. It would be nice if in cases like that of MZB (mentioned above) that the fact that you are using someone else's characters would waive your right to sue them.
"If someone infringes on your copyright, and you are aware of the infringement, and you do not defend your copyright, the law assumes that you have abandoned it."
I certainly believe this to be true of trademarks. From wikipedia (I know that is not a definitive source, but I was unable to find anything that addresses the issue on anywhere more official (e.g. USPTO).) "As a trademark must be used in order to maintain rights in relation to that mark, a trademark can be 'abandoned' or its registration can be canceled or revoked if the mark is not continuously used. By comparison, patents and copyrights cannot be 'abandoned' and a patent holder or copyright owner can generally enforce their rights without taking any particular action to maintain the patent or copyright. Additionally, patent holders and copyright owners may not necessarily need to actively police their rights. However, a failure to bring a timely infringement suit or action against a known infringer may give the defendant a defense of implied consent or estoppel when suit is finally brought."
This (http://www.nolo.com/legal-encyclopedia/faqEditorial-29067-6.html) lists several defenses to copyright infringement. Abandonment of the copyright is nowhere mentioned as a defense.
I'll grant you I wasn't able to come up with any truly convincing sources to support this, but all of the not-so-authoritative sources that mention the necessity of enforcement describe it as part of trademark, but not of copyright.
Re: Copyright must be defended?
Ah! Thank you. This is what I was trying to express above, but you did it much more cogently.
no one mentioned one crucial aspect of copyright law -- a copyright MUST BE DEFENDED. If someone infringes on your copyright, and you are aware of the infringement, and you do not defend your copyright, the law assumes that you have abandoned it.
I think that's trademarks that you have to defend, or risk losing 'em. Hence the bits in writer magazines about Xerox and Kleenex being brand names & trademarks, not verbs or generic terms. I googled*, and found this -- see #5.
But anyways, that's a nitpick, and not meant to try to go all xkcd ("wrong!"). Personally, I've never been much into fan fiction; probably because the first few examples I found back in the '90s weren't terribly good. I'm sure there's some awesome examples somewhere, but I've got so many books that I've bought and need to read, I don't have time to search for good fan-fic.
It is almost certainly true at this point that "google" has become genericized and even if defended could not be rescued in the same that kleenex and xerox got genericized years ago. Google does have a history of vigorously defending their trademark though, so it is possible they haven't crossed the line yet. Google is very aware that their brand is their power and they really really don't want to see it go public domain, but sometimes these things are unpreventable.
I've been torn on the issue for years now. I don't write fanfic, taking other writers' worlds and characters - I have enough of my own characters bugging me day and night - but I wondered what I'd do if I were faced with the question. I've heard people talking about how MZB allows fanfic with open arms, but they seem to have the story a little skewed, and are telling it as though she readily shares payment with co-authors or something. Interesting to hear the corrected story told.
I see what you're saying, and I think I agree. Still have loads of time to consider, myself, but I do think I agree with this stance.
I have nothing to add, but I do want to thank you for writing this.
I came late to the fanfiction party, as a reader (in my 4th decade). Apparently I'd been writing it since I was about 13--stories for my own amusement, set in the worlds of TV shows I loved (oddly, it has never occurred to me to write in the worlds of books I loved). And I remember well when MZB stopped her interaction with fans' fiction set in Darkover.
I'm fairly sure, short of constant litigation (for which few independent authors have the resources), that fanfiction as currently defined is impossible to stop. Curbed, yes, and as long as there is the periodic "cease and desist" I believe the copyright issue will be protected. And of all the arguments against fanfiction, that is the one I think matters most. I know too many working artists not to be sensitive to it.
Ultimately it has to be the generating author's decision, and I think the fan community has a responsibility to follow that author's wishes. For me that means if an author allows fanfic, then I will read it. If, like you and Ms. Gabaldon, you don't want printed and shared, then it is my obligation to not read it, and to do my best to see that others don't.
I am under no illusion that will be something embraced by all, but I think that's the ethical thing to do. That said, I will continue to fill the notebooks beside my bed with the stories I think of that are filled with other people's children. No one else has ever read those, and no one else, I hope, ever will, except over my dead body (literally).
That may be a contradiction, but if so, it is one I can live with. I draw a sharp bright line between the things I write for my own pleasure, and those I write to share.
I agree with all the points made in Mr. Martin's original post.
I also want to reiterate one of the points that Ms. Gabaldon has made on fanfic, which is, the publishing of it makes a world of difference.
For those who want to write fiction using pre-made characters and world settings, doing so in their own privacy is something between them and their own typewriter/computer. Nobody else needs to know about it, and as long as it remains private, unpublished, it is nobody else's business. No more than it's anybody's business if a fan has a fantasy of being one of the characters in their own heads.
The difference comes when the work is published. Whether it is published on the web, in your blog, on your FB, or in print, or if you just scrawl it on the local truckstop's bathroom stall. At that point, it ceases to be harmless.
I'm curious what the harm you see in it being published is. I can see how it's harmful if they're collecting money for it, absolutely... but on your website for free?
I see your point, George. I understand it and I can accept it, although I can accept those writer's decision too who support fan fiction.
It should be (very simply) always the decision of the writer, if he/she allows it or not.
Myself, I prefer the 'original' stuff, so I only read from the original authors always.
Though I may disagree with what you have to say, I will defend to the death your right to say it.
It's your story, your characters, and thus your choice. As has been mentioned Webmasters are generally willing to take the authors side, likely for the same reasons publishers do. Especially since they are likely making even less per story posted on their site than a publisher is per book they pop out.
Other peoples opinions on whether or not your work is open to others are moot. They are, by all means, entitled to their opinion don't get me wrong. But it is possible for an opinion to be wrong, and this is a perfect example of such a time.
However I don't think any hard or fast law should be fashioned to cover all fan fiction since as you note yourself there are authors who actively encourage their fans to write fan fic. And as has been mentioned here, and I'll assume in the blog that sparked this entry, people use fan fic to hone their writing skills and massage their creative juices into flowing. And lets be fair it seems an authors major issues are getting those juices flowing so learning tricks while borrowing others ideas to help them is likely a good way to get started on before graduating to getting their own worlds.
Does that mean they should be allowed to publish works that use your, or other, authors worlds/characters? Not without the express written permission of said authors. Writing for fun and practice is one thing, doing so to make a living is another.


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Find the answer in the text below.
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text:
package com.mattunderscore.specky.licence.resolver;

import java.util.Optional;

/**
 * Licence resolver.
 *
 * @author Matt Champion 28/12/2016
 */
public interface LicenceResolver {

    /**
     * @return the licence mapped to the name or the default licence
     */
    Optional<String> resolveLicence(String name);
}

redpajama_set_name: RedPajamaGithub