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With The Game, Queen broke all the rules, including its own
Jason Heller
In We're No. 1, The A.V. Club examines an album that went to No. 1 on the Billboard charts to get to the heart of what it means to be popular in pop music, and how that concept has changed over the years. In this installment, we cover Queen's The Game, which went to No. 1 on September 20, 1980, where it stayed for five weeks.
"And nobody played synthesizer," brags the liner notes of Queen's self-titled debut album. Released in 1973, the album came out during a time when synthesizers were just beginning to make inroads into mainstream rock—despite that, two years earlier, The Who had proven the viability and vitality of the instrument on Who's Next hits like "Baba O'Riley" and "Won't Get Fooled Again." Queen's insistence on synth-free purity was somewhat understandable. With Queen, the band ushered in a new and extravagant use of studio manipulation the likes of which might have made George Martin blush. In Queen's hands, the tape machine became even more of a symphonic tool than it had been on Sgt. Pepper's. But that was a painstaking, exacting process. Synthesizers were seen as a shortcut, a cheap crutch. Their very name screamed "synthetic." The irony being, there was never anything naturalistic about Queen's decadent, fantastic glam.
The first sound heard on "Play The Game," the opening song of Queen's 1980 album The Game, is a synthesizer. Throughout the rest of the record, almost everybody in the band—save for bassist John Deacon—plays synthesizer. Queen had broken one of its own written-in-stone rules. But it wasn't the only rule The Game broke. From the funk of "Another One Bites The Dust" to the new-wave power-pop of "Coming Soon" to the rockabilly of "Crazy Little Thing Called Love," the album was a major refutation of the idea—prevalent then and now—that a mainstream band must sound like itself, whatever that sound is understood to be.
Queen wasn't the first rock band to succeed by adopting many styles. Everyone from David Bowie to U2 to Radiohead is proof that groups can embrace diversity and become beloved because of it. But in those cases, the music evolved gradually—and the diversity isn't very broad within any particular album. Queen loved its records to be smorgasbords. On albums like 1975's A Night At The Opera and 1978's Jazz, the band trafficked in a variety of musical genres, a dizzying dynamic that could turn on a dime from one track to the next. A Night At The Opera's (and ultimately Queen's) biggest hit, "Bohemian Rhapsody," contains a multitude of styles within a single song. Bowie is generally credited with being rock's foremost musical chameleon, but Freddie Mercury and crew could pack more changes into six minutes—and make them feel playful rather than cerebral—than Bowie could in an entire album.
Still, nothing Queen had done before fully predicted The Game. "Play The Game" used synthesizers to ice Mercury's sweeping pep talk to the lovelorn, but it sits at the far end of the spectrum from the album's most popular track, "Another One Bites The Dust." If Queen, in all its variety, had a hallmark, it was painstakingly layered ornamentation and multidimensional harmonies. Here was a song as stark as a skeleton. Locked into one of the tightest grooves of the era—and this was the age of disco—"Another One Bites The Dust" feels like a fully realized reprise of "Fun It," a tepid track from Jazz that marked Queen's tentative entry into slick, stark funk. Jazz was not a well-received record, and "Fun It" was a small part of that. Whatever possessed Queen to restrain its ballooning grandiloquence and dig into the funk, while making "Another One Bites The Dust" can only be chalked up to blind faith—or cocksure swagger.
But there's another, more contentious antecedent to "Another One Bites The Dust." Chic's "Good Times" came out in 1979, and its crisp bite helped revolutionize disco, not to mention dance music, for decades to come. It also gave Queen critics plenty of ammunition, considering Deacon's bass line for "Another One Bites The Dust" bears a striking resemblance to Bernard Edwards' in "Good Times." Deacon had even visited Chic in the studio in 1979 when the group had been recording the album "Good Times" appears on, Risque. As detailed in Mark Blake's Is This The Real Life?: The Untold Story Of Queen, Deacon didn't deny it. As for Edwards, his main regret was that some people mistakenly thought Chic had ripped off Queen. That the two tracks were so similar is testament to how adeptly Deacon—who'd cut his teeth playing Motown covers in his little-known '60s band The Opposition—had been able to credibly appropriate funk's cutting edge.
Queen wasn't only hooked on synth-and-funk futurism. The Game's other major hit nearly gave itself whiplash in its rush to glance backward. "Crazy Little Thing Called Love" is a rockabilly tune: simply rendered, lovingly reverent, and euphorically unhip. The only thing it has in common with "Another One Bites The Dust" is the fact that Jazz presaged it: That album's "Dreamer's Ball" is a eulogy to the recently departed Elvis Presley. That said, "Dreamer's Ball" only barely echoes the languid crooning of The King, mixed as it is with guitarist Brian May's baroque electric guitar. "Crazy Little Thing Called Love" is a sharp slap back, a song that could pass as a cover of some long-lost Elvis outtake. With all the twist and twang of a late-'50s sock-hop staple, the song shows Mercury indulging in nostalgia that's neither corny nor maudlin—and barnstorming his way into a liberating anachronism. After being tagged for so long as a progressive rock band, Queen seemed to relish the idea of confounding the world by hip-swiveling into the past.
The rest of The Game falls between the poles of "Crazy Little Thing Called Love" and "Another One Bites The Dust," but none of it is filler. In addition to the soaring "Play The Game" and The Cars-like "Coming Soon," there's the boogie-metal wizardry of "Dragon Attack," the chugging dance-punk of "Rock It (Prime Jive)," and the strangest would-be PSA in the annals of rock, "Don't Try Suicide," which comes with the bouncy refrain, "Don't try suicide / Nobody cares." Offsetting the occasional flashes of flippancy is the album's closer, "Save Me." An alternately delicate and bombastic ballad cut from the same cloth as Queen's 1976 classic "Somebody To Love," "Save Me" was written by May and sung by Mercury with such crystalline virtuosity, it's astounding just how heart-piercing—how small and vulnerable—its majestic choruses sound. It's one of the Queeniest Queen songs ever: an anthem for the beer-spilling cheap seats that still feels sinfully luxe.
In his 1979 Rolling Stone review of Jazz, Dave Marsh called Queen "the first truly fascist rock band." (This was a few years after David Bowie had been accused of Nazism, which logically makes the Queen-Bowie collaboration "Under Pressure" the Axis alliance of '80s pop.) But Marsh's charges of arrogance and elitism were utterly disarmed by The Game. The album is fun, funky, stripped down, inclusive, intimate, and at times sympathetically tender—qualities made all the more generous by Mercury's ascendant rock godhood, the result being Queen's first and only number-one album in America. It also gleefully violates fascism's defining principles: It couldn't care less about discipline or order. The Game played the game—and it won, not by its own rules, but by rejecting rules altogether.
MusicFeaturesWe're No. 1


The confluence of WTO issues and budget-cutting in Washington could end up exposing growers to more price risk in the future, creating a bigger role for grower price risk management.
Although it's still uncertain as to when the next farm bill will be written, some pieces of it seem apparent already. "I would wager a bet that it's going to be leaner, poorer and probably more de-coupled from production to make it more WTO compliant," said John Robinson, Extension economist, Texas A&M University.
The economist is stressing that the opportunity to sharpen marketing skills in preparation for the reduction or loss of a safety net is of paramount importance.
Doing so could also be key to another winter worry — getting financing. With a price floor in place using marketing tools, growers can show their bankers that they have a plan for whatever price scenarios occur.
The first thing you should do to hone your marketing skills is to have a very clear and detailed idea of your cost of production. "Otherwise, you're shooting blind," Robinson said.


Blue Jay Families are invited to participate in a number of events throughout the academic year. Explore the list below to learn more about these events.
Interested in helping to plan and coordinate programming and events? Consider becoming a Blue Jay Family Ambassador!
Throughout the summer Send-Off Parties are being held in many cities across the country and around the globe to welcome Class of 2022 families. Please join us at a Send-Off Party near you to gather with fellow 2022 families, current families, alumni and university staff. We look forward to meeting you!
The Orientation and First-Year Experience office provides support for new students and their families to encourage a successful and enjoyable first year at JHU. Orientation occurs immediately following move-in to the residence halls.
New Student Orientation 2018 is Saturday, August 25 through Wednesday, August 29, 2018. The five-day orientation program will help prepare your student to successfully transition to JHU. Your Blue Jay will learn about academics and student life, meet with an advisor and a First-Year Mentor (current student), and connect with their new community.
We encourage you to attend Parent and Family Orientation to learn more about all the JHU has to offer your student! Families learn about academic and student support services, hear from university administrators, and meet fellow Blue Jay Families. Parent and Family Orientation 2018 will be held Saturday, August 25 beginning midday through Sunday, August 26, ending in the early evening.
If your student is participating in a Pre-Orientation program, you do not have to return to campus for orientation and will have the opportunity to participate in a condensed Parent and Family Orientation immediately following your student's move-in.
Join us for Family Weekend to explore the campus community, connect with faculty and staff, meet fellow Blue Jay Families, and experience JHU with your student. The three-day event is packed with tours, class lectures, meet and greets, cultural events, and much more to connect you to the campus and your student's new home.
Please mark your calendar! Family Weekend will be held Friday, October 25 through Sunday, October 27, 2019. We encourage you to make your hotel reservations early!
Undergraduates in the Krieger School of Arts & Sciences and the Whiting School of Engineering will participate in the university-wide commencement ceremony held at Royal Farms Arena on Thursday, May 23, 2019, at 1:30 p.m. Doors open at 12 p.m. and graduates line up at 12:30 p.m. The ceremony begins with the procession at 1:30 p.m. and is expected to conclude by 5:30 p.m.
If your schedule permits, consider arriving on Wednesday, May 22, to join your graduate for other Commencement-related activities. The schedule of events will be updated throughout the year with student organization and academic department events happening on the Homewood campus on the 22nd.
Tickets are not required. Accommodations including ASL interpreters, assisted listening devices, or Braille program booklets are available for commencement attendees needing assistance. Contact the Commencement Office at commencement@jhu.edu or 410-516-7711 by April 23.
Parking near the arena is limited. Ceremony attendees are encouraged to utilize public transportation, taxis, rideshare services, or the Commencement shuttle from the Homewood campus. More information about transportation options is available on the Commencement website.
Our Visitor Information page has external links to hotels near the arena, frequently asked questions, details on event accessibility, and suggestions to help you commemorate your graduate's moment. The Commencement Undergraduate Checklist contains information on ordering graduation-related items, including class rings, graduation announcements, senior portraits, and academic regalia.
In mid-November, parents of students expected to graduate in May should have received an email from the Commencement Office. If you did not receive or have questions, please contact the Commencement Office at commencement@jhu.edu, call 410-516-7711 or message us through Facebook or Instagram.


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including currently available Asteromyrtus, and Asteromyrtus for which we do not have a current source.
Search and Shop also allows for searches with just bits of the name: cap iki Useful if you only have part of the name. Spaces are used as wildcards: Asteromyrtus.


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Superfast Broadband
I have always been enthusiastic about the potential for modern fibre optic infrastructure like Superfast Broadband to put Cornwall ahead of the pack and to help overcome some of the geographical challenges we face as a peninsula. Infrastructure today is not just about roads and rail (important though those are), it is also about digital connection. The way that many modern industries like computer software operate means that, if we get the fastest broadband speeds, we are ahead.
Cornwall has so much beauty that many entrepreneurs actually want to set up their business here provided they have the right infrastructure. A couple of months ago I visited Head-Forwards Software which is one of a number of new computer software companies that are bringing new jobs to this part of Cornwall. Evidence suggests that almost 90 percent of the economic benefits of investment in broadband flow to areas outside the South East and the Home Counties. That makes a change and it is why investment in digital infrastructure is one of the best regional policies you can have.
The project to install Superfast Broadband across Cornwall is moving to its final stages. By end of this year they hope to reach their target of 95% of businesses and homes connected. Much progress has been made with over 80% of Cornwall now having access to fibre broadband. This equates to 210,000 premises, 21,000 of which are businesses. By the end of the year, with enough fibre optic cable to circle the globe three times 95% of Cornwall will have access to superfast.
What makes the project even more innovative is that alongside the normal superfast broadband being installed there is a further roll out of an even more advanced system that gives people even greater speeds, known as fibre to the premises or FTTP. Cornwall is now home to half of all the households in the country that have this cutting edge technology which increases internet speeds by up to forty times what we now experience. That's worth repeating: half of all the homes in the UK that have fibre to the premises can be found in Cornwall.
This is really positive news, and whilst I know some people are concerned that their house or business is not yet covered it is reassuring that the vast majority will finally have access by the end of the year. For the last remaining 5% where it is too difficult, the provider is going to make sure they will still see a boost in speeds using alternative methods such as advanced copper wiring or satellite. It is important this is done properly because I want to see every home; even those in the most remote areas see a difference from this investment.
George Eustice can be contacted at george.eustice.mp@parliament.uk or 1 Trevenson Street, Camborne, Cornwall TR14 8JD or by telephone on 020 72197032.
As each month goes by, there is growing evidence that the economy has turned a corner. Growth is predicted at 2.4 percent. There have been 400,000 new businesses created since 2010 and over 1 million new jobs. Unemployment is falling and now stands at its lowest rate since 2009. In Camborne and Redruth, unemployment is at 3.3%, lower than the national average.
One of the main priorities for the government has been to make work pay again. I have met too many people who say that if they work more than, say 16 hours a week, they lose more in benefits than they would gain in wages. We have to reform the benefits system so that it always pays to work longer hours. The new Universal Credit will have a tapered system so that you avoid sudden drops in benefit entitlements and by placing a cap on the maximum amount any one household can claim in benefits and reducing benefits like Housing Benefit, you increase the incentive to work.
However, the other side of the equation is trying to raise the income on those who are low paid and on the minimum wage. At the moment almost one and a half million people receive the minimum wage which is set at £6.31 per hour. Those who are at the lowest end of the pay spectrum have also had to grapple with the spiralling inflation left behind by the last Labour government. Inflation is now decreasing but the previously high rate has meant that even though there has been a strengthening of our national economy in real terms this hasn't been allowed to really hit home and find its way into people's pockets.
At the end of last week George Osborne said that it was time to consider increasing the national minimum wage because the returning strength to our economy means an increase can now be afforded. It's a difficult to get the balance right in a place like Cornwall. On the one hand, we know if we want to make work pay and help those on the minimum wage, we should be trying to increase the pay of those at the bottom. On the other hand we have a larger number of small businesses who are themselves struggling and we don't want to make it harder for them to take people on and create new jobs.
Both George Osborne and the Low Pay Commission, who advise the government on the minimum wage, have signalled that the rate should stand at £7 an hour which would be slightly above the rate of inflation and would see the wage return to its proper value before the recession hit. This will be a welcome boost in income for those on the minimum wage and should also increase the incentive to get off benefits and get into work.
Compassion and Charity in CPR
I have always hated the way some people talk down my home towns. Camborne, Redruth and Hayle have undoubtedly had their share of knocks in recent decades but this is also the part of Cornwall where the work gets done and where stuff gets made. There is real talent here, we can hold our own against any other urban centre in the country and we have an amazing industrial heritage to be proud of.
So I was very annoyed to read a recent article written for the Guardian newspaper by an academic who basically set out to trash our area and claim, extraordinarily, that there was a lack of small local charities. What makes it especially irritating is that I met the author, James Mumford, a year ago because he contacted me about his project. I gave him a whole list of excellent charitable organisations all doing their bit and encouraged him to see their work.
The community at Pengegon he cited is rightly proud of what has been achieved in recent years with antisocial behaviour down dramatically and a strong community spirit. I attended the community fun day last August organised by Claire Arymar and the atmosphere was great. Andy Richards, the local PCSO not only polices the area but runs football and basketball teams for younger residents in his spare time and he and the other members of the neighbourhood policing team have become highly respected.
If he had taken my advice, the author could have visited groups like Home Start, where volunteers offer practical support in the home for struggling parents. He could have visited WILD which supports girls trying to cope with the responsibilities of motherhood. He could have visited Young Mums Will Achieve which raises aspiration among single mothers. He could have visited charities like CN4C, the Redruth North Partnership or the All Saints Community Centre at Tuckingmill which each in turn host many vibrant social enterprises and charities on the front line. He could have visited some of the food banks run by volunteers from our churches. He could have visited great charities like Penhaligon's Friends where volunteers support children who have suffered bereavement. Or he could have visited small youth groups like Searchlight where he would find local children, who haven't got much for themselves, regularly donating some of their modest pocket money to help less fortunate children in developing countries. This part of Cornwall doesn't need lectures on charity.
As for his comments about our schools, I have visited over thirty schools in the Camborne and Redruth area in the last couple of years. Many have opted to become academies and standards are rising with interventions to ensure primary school children learn to read and write and with new school uniforms and a renewed focus on maths, science and languages in all our secondary schools. We can be proud of our schools and the next generation coming through.
The main argument of the article was that small charities have an important role to play in helping to get communities back on their feet. I don't disagree with that. However, there is another factor that holds some parts of the country back: low self esteem. I want to see our towns get their confidence back because we can beat the best of the rest and what we don't need are people only expressing defeatist and negative sentiments about our area.
The Triple Lock
Over the weekend David Cameron made a really important pledge to continue the 'triple lock' protection for pensions if the Conservatives win the next election. This promise was one of the key Conservative manifesto commitments during the election almost three years ago and an election victory would mean it would continue to at least 2020. I think this pledge is really important because the idea is straightforward and because it offers huge peace of mind to people drawing pensions up and down the country and especially in Cornwall.
The 'triple lock' is simple. It ensures that state pension pay rises by whichever is higher out of inflation, wages or 2.5%. It also protects the state pension from variation in the economy, because it doesn't attach payments in any way to average earnings which can fluctuate all the time. By April this year, the basic state pension will be £440 a year more than if it had been pegged to average earnings from 2011 onwards. That is a substantial amount and a huge help in what has been difficult economic times.
I think the 'triple lock' has been a success for the Government and this pledge offers some reassurance for those in retirement. Our pensioners are people who have contributed a huge amount to society and have been sensible in saving money for the future. After a life of hard work and supporting their families, they deserve a dignified old age without financial worry and a pension that provides some security for them. When I meet either groups of older people or individuals I am often reminded of how their pension offers a real lifeline and the capacity for independence which could otherwise be lost.
Some people are critical of the policy and say that pensioners should face cuts too but I think that ignores the fact that people have contributed all their lives. It is strange to criticise a protection for those who have already done their bit.
However, helping provide a little more security for pensioners doesn't negate the need for us to help the next generation too. In many ways it is a difficult time for school leavers who have to contribute more to their university education and young families who find it hard to raise the deposit to buy their first home. It is why schemes like the Help to Buy initiative to help people with their deposit are so important and why we must do more to encourage apprenticeships to give school leavers a good start. This weekend I will be attending the launch of a great initiative from Truro College that wants to encourage business to employ more apprentices throughout Cornwall and is just one example of the important steps being taken to support those just starting their working lives.

redpajama_set_name: RedPajamaCommonCrawl


I am a loud sneezer. When I sneeze, people notice. Heads bolt upright, like gazelles on the savannah . . . what just happened? what might come next? . . . when in fact it was only me, sneezing. And what comes next, generally, is a second sneeze. And then it's over.
I type this on my Blackberry, waiting for my train, having just left the sushi place in the Food Mall in the basement of Union Station. (Obviously, Charles is not with me.). Moments ago, sitting, sipping my diet Coke, suddenly — ha-SHEEESH!
The sushi chef's head snapped up from his work. Passers-by swiveled. A transit cop reached for her gun. But then, almost as fast, shoulders relaxed and looks of amusement crossed people's faces as they began to make sense of it.
An attractive young couple standing at the sushi cash register smiled broadly. Anything is novel and noteworthy when you're young and in love.
'God bless you he said,' almost a little too earnestly, leaving me to wonder whether he was playing along or a young missionary come to work for the Romney campaign.
I figured I might find out on the trip to New York, but they were evidently headed someplace else.


College practice or small internship is a very important aspect of every learning process. Students are given the opportunity to actually engage and participate in real life projects which eventually allows them to gain experience which normally they would not be able to gain in college.
Companies which participate in such internship programs have standards and certain expectations from students that engage in practice. Vega IT, as one of those companies, has strict standards when it comes to programming which every employee follows and which every student will learn about during the internship.
Strong knowledge of object-oriented programming. Fundamental concepts such as abstraction, encapsulation, inheritance and polymorphism.
Basic knowledge of how the web works (browser, web server, DNS, etc.). Concepts only, details are not required.
Good knowledge of ASP.NET MVC framework.
Source control such as TFS, SVN or Git.
Basics of HTML, CSS, XML and JSON.
Basic knowledge of SQL. Writing queries for select, update, delete and insert, operations against relational databases.
English language, writing and speaking.
Open-mindedness and soft skills are a big plus.
If you believe in what we believe in and you feel eager to learn, work and further develop yourself, apply for this job by sending us your CV in English electronically at jobs@vegait.rs and join the Vega IT team.


James Hankins discusses how NC State's political science and Teaching Fellows programs influenced his decision to attend the university.
00:00:00.000 Initially my career path from day one since I'm in middle school was to be an actor slash writer slash producer.
00:00:11.199 That's what I wanted to do. My cousin and I were trying to write movies. I wrote a couple plays and stuff that were terrible, but I wrote plays and stuff.
00:00:20.081 I got involved in music a lot and I was into making music and stuff like that. All that stuff was there.
00:00:34.833 and people that got elected and what they did was very important and that we have a responsibility to pay attention to that.
00:01:04.831 so I thought that was fantastic.
00:01:12.772 and State was the type of school that, you know, I wanted to experience that, and it wasn't-.
00:01:39.648 and the education program here, especially through Teaching Fellows, was fantastic, so that helped make my decision.
Terry Carroll cites Sputnik and his interest in rockets as his motivation to attend NC State to study aerospace engineering.
J. Robert Cooke talks about realizing an interest in agricultural engineering while in high school and deciding to enroll in the program at NC State.
Ed Stack talks about how he always wanted to attend NC State.
William Jackson discusses how an early interest in electricity led to him to study electrical engineering at NC State.
William Friday describes the School of Textiles in the 1940s and recalls what it was like to operate textile machines.
Chandler Thompson talks about wanting to attend NC State even from an early age.
Cathy Sterling discusses transferring from the University of North Carolina at Chapel Hill, where she studied music, to NC State.
Blas P. Arroyo describes how he decided to study pulp and paper science at NC State.
John Atkins explains his interest in architecture as the reason he applied to college at NC State.
Smedes York talks about the York family tradition of attending NC State, always wanting to be in the family business, and always wanting to go to NC State.
John Earnhardt discusses how, while he was in high school, he decided to study engineering and therefore to attend NC State.
Governor James Baxter Hunt, Jr. discusses why he chose to attend NC State, as well as his decision to change his major.


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Walmart preparing to administer COVID-19 vaccine once approved
by: Heath Higgs and Nexstar Media Wire
A Walmart store sign is visible from Route 28, Wednesday, Nov. 18, 2020, in Derry, N.H. (AP Photo/Charles Krupa)
BENTONVILLE, Ark. (KNWA/KFTA) — Walmart is preparing its pharmacies to receive and administer the COVID-19 vaccine once it's approved in the United States, according to a company blog post on Thursday.
The retailer said its more than 5,000 Walmart and Sam's Club pharmacies are making sure they have freezers in place, as well as dry ice, to handle any requirements for storing the vaccine.
We are sharing a few of the steps we're taking at Walmart to be prepared once a COVID-19 vaccine is approved in the U.S. Learn more about the preparations and processes we are putting in place to administer the vaccine. https://t.co/bO51DxZ34p
— Walmart Inc. (@WalmartInc) December 10, 2020
"With 90% of the American population living within 10 miles of a Walmart, we will play an important part in making sure those who want a vaccine can get one when they are eligible based on their state's prioritization, especially those in hard to reach parts of the country that have recently been hit hard by the epidemic," Dr. Tom Van Gilder, Walmart's chief medical officer, said in the post.
Walmart said it is also preparing to enter into an agreement with states to support vaccinations where needed, "whether that is in our pharmacies or long-term care facilities where the states determine they need our help."
Additionally, the company is preparing processes to inform people when to receive the first and second dose and to report successful vaccinations, as well as educating its employees about the vaccine, "so when they are determined to be eligible, they will understand and be ready to receive the vaccine if they choose."
The first vaccines are likely to require two doses, which will need to be separated by 21 or 28 days, and will be available in limited quantities.
A committee of outside experts is scheduled to vote on Thursday on whether the U.S. Food and Drug Administration should authorize the use of the vaccine developed by Pfizer and BioNTech. The vaccine is reportedly 95% effective at preventing COVID-19.
Meet this week's Perfect Pet: Richard
But thanks to a $60,000 grant from the Community Foundation of the Lowcountry, VIM has been able to branch out and take care of patients outside of the clinic.
by Molly Curley, Archith Seshadri / Jan 21, 2021
ATLANTA (WSAV) – Gov. Brian Kemp says right now, a limited supply is the biggest hurdle in Georgia's COVID-19 vaccine distribution plan.
The state has been allocated 120,000 doses each week from the federal government, with one-third set aside for vaccinations at long-term care facilities.


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Due to the COVID-19 Pandemic, this event has been postponed. Tentatively, we plan to reschedule the summit for Spring 2021. In the meantime, we are planning for a virtual conference in May 2020, to address the societal challenges related to the pandemic from wisdom, character, and morality perspectives. Please, check our website in two weeks for further details.
Santushi Amarasuriya, PhD
Local Host
Santushi Amarasuriya is a Senior Lecturer at the Department of Medical Humanities in the Faculty of Medicine of the University of Colombo, Sri Lanka, in which she has been on the academic staff since 2006. She is a Clinical Psychologist by profession and obtained her PhD from the University of Melbourne in 2016. She has received the Head of School Award for Excellence in Doctoral Research from the Melbourne School of Population and Global Health, in which she is also an Honorary Fellow, and the President's Award for Scientific Publications by the National Research Council of Sri Lanka. She is the Project Director of a Project measuring and developing wisdom in Sri Lanka and the Philippines funded by a Global Innovations for Character Development Grant through the Templeton World Charity Foundation Inc. She is also involved in research focusing on examining the portrayal of kindness in healthcare in Sri Lanka, developing an emotional intelligence measure for use among healthcare professionals, assessing psychological correlates of mental well-being in undergraduates and is a member of a research team from the University of Colombo working towards developing meditation and mindfulness based interventions to improve health-related outcomes.
Eranda Jayawickreme, PhD
Eranda Jayawickreme is an associate professor of psychology at Wake Forest University. Currently, he is the Project Co-Leader of the Exemplar Interventions to Develop Character Project, a $1.68 million initiative funded by the John Templeton Foundation examining the role of moral exemplars in character development. Jayawickreme was also the Project Co-Leader for the Pathways to Character Project, a $3.4 million initiative examining the possibilities for the strengthening of character following adversity, challenge or failure, and the Project Leader for the Promoting Intellectual Humility Among Middle-School Students: Developing an Educational Film and Preliminary Intervention Strategy Project. From 2011 to 2014, he was the Project Leader for the Growth Initiative, which focused on improving the quality of research on post-traumatic growth.
Jayawickreme received his PhD in positive and social/personality psychology from the University of Pennsylvania in 2010. His research, which integrates his interests in both philosophy and psychology, focuses on post-traumatic growth as positive personality change, moral personality, wisdom, well-being and integrative theories of personality. He has worked with populations in Rwanda, Sri Lanka and various populations in the USA. His awards include the 2015 Rising Star award from the Association for Psychological Science (which recognizes outstanding psychological scientists in the earliest stages of their research career post-PhD whose innovative work has already advanced the field), Wake Forest's 2018 Faculty Excellence in Research Award, a Mellon Refugee Initiative Fund Fellowship, and grants from the John Templeton Foundation, the Templeton Religion Trust, the Templeton World Charity Foundation, the European Association for Personality Psychology, and the Asia Foundation/USAID.
Igor Grossmann, PhD
Igor Grossmann is one of the most prolific and accomplished social-personality psychologists of his generation, and among the top contributors to psychological science in Canada. In his work he aims to unpack the philosopher's stone of judgment and decision-making research – the concept of wisdom and sound judgment. His work has been published in such outlets as Proceedings of the Royal Academy: B, Science Advances, PNAS, Perspectives on Psychological Science, Psychological Science, Journal of Experimental Psychology, and Journal of Personality and Social Psychology. His contributions have been recognized through numerous awards (e.g., Joseph B. Gittler Award from the American Psychological Foundation, SAGE Young Scholar Award from Society for Personality and Social Psychology, APS Rising Star Award, APA Div 20 Dissertation Award, USERN Prize for Social Sciences). Grossmann is also an Associate Editor of two of the most prestigious journals in psychology (Social Psychological and Personality Science and Emotion), and co-hosts the "On Wisdom Podcast," aiming to disseminate scientific insights from psychology, philosophy and cognitive sciences to the broad academic audience and the general public.
Hotel, Travel, and Visa
Sri Lanka 2020 © 2022. All Rights Reserved.


text:
in: Characters, Background characters, Minor characters,
Video game characters
Bikini Bottomites
Bubble Buddy (character)
Bubble Buddy is a living bubble, who was created by SpongeBob in the episode "Bubble Buddy."
He was at first thought to just be an inanimate object, but when he was about to be popped by Squidward, he showed he was actually alive by grabbing Squidward's wrist, which surprised everyone else (besides SpongeBob who knew he was alive the entire time). Bubble Buddy also has a son and brother, his son is named Shiny Bubble, and had a large apperance in the episode "Bubble Buddy Returns," while Bubble Buddy himself only had a minor apperance in the episode.
As well Bubble Buddy was known to accidentally cause trouble in his first apperance, as he had done many things to make almost the entire city of Bikini Bottom wanting him popped. The things that he did such as: at the Krusty Krab he forced Squidward to remake the Krabby Patty many times. According to SpongeBob, Bubble Buddy is lactose intolerant, and because of this, drinks shampoo instead of soda. He also prefers no crust, pickles to the left, four squirts of ketchup, wheat buns, non-deli lettuce, and farm raised tomatoes; carnival style, and at some point before eating requires a massage. He also fails to pay for the meal, paying in "Bubble money", which is not real and quickly pops which makes Mr. Krabs angry. Later on, at Goo Lagoon, SpongeBob and Bubble Buddy continue to make trouble.
SpongeBob leaves Bubble Buddy with Scooter, who is buried up to his head in the sand, saying that he will unbury him, but doesn't and Scooter drowns when the high tide comes.
When Bubble Buddy "has to go to the bathroom", SpongeBob leaves him in the bathroom for about two hours, making everyone else wait making them angry. While dancing with Bubble Buddy, SpongeBob inadvertently insults the other dancing beach-goers by saying "shake that bubble butt", which the people take as calling them fat. When Bubble Buddy shakes Pearl's hand, which had just been dirtied by Grubby Grouper, making her never wanting to wash it again, it is though cleaned off.
After all these incidents, an angry mob is formed, who surround SpongeBob and Bubble Buddy. Just as he is about to be popped by a needle, Bubble Buddy suddenly becomes alive, much to the shock of the people (except for SpongeBob), and decides to leave, saying that "things are getting a little weird around here." A bubble taxi then picks him up and he leaves with a suitcase and disappears into the sky. He then says, "Happy Leif Erickson Day!," to SpongeBob. Nobody seemed to mind that Bubble Buddy left as they agreed that this is still okay for all of them.
"Bubble Buddy" (Debut)
"Bubble Buddy Returns"
He makes an appearance in the game Battle for Bikini Bottom, as a tip giver and mission giver.
Background characters


Speedcross 4 vs Speedcross 4 GTX are trail running shoes that are suitable for difficult and challenging climbing sessions. They are nimble and responsive, allowing you to climb with ease. However, they are indeed equipped with different features. Continue reading below to find out the differences between these two models.
– Which shoe model that is more recommended for the money.
Those who are familiar with the fit of old Speedcross models may find an immediate comfort with Speedcross 4. The sizing is precisely similar to the predecessors, featuring a snug toe box that is more suitable for people with average to narrow feet. One thing for certain, Speedcross 4 is not suitable for people with wide feet because it is quite narrow. See also: Speedcross 4 vs Speedcross 4 CS.
Speedcross 4 comes with the quick lace system. One nice thing about this system is that it allows you to quickly and easily put on and off the shoe. Also, there is a built-in pocket in the tongue for storing the lace. However, this system doesn't allow you to customize the fit with a single pull. Hence, some people think that it is not very practical.
Speedcross 4 has good cushioning and stability. Note that it has a dramatic drop from the heel to the toe. As the effect, this shoe is especially suitable for climbing steep hills and mountains. But it is not really great for walking or running on relatively flat terrains. According to Salomon, Speedcross 4 features the Ortholite liner and a thick EVA foam midsole which feels comfortable.
Durability and ventilation are two things that may seem contradictory to each other. When you make a breathable shoe, it often becomes not weather resistant. This is the case with Speedcross 4. The said model does not have a weather resistant upper. Hence, although it is comfortable, things become annoying when the shoe gets drenched by rain or water puddles.
Speedcross 4 GTX is a variant of the original Speedcross 4 that aims to eliminate a single yet significant problem, which is the poor weather resistance. While the original model has issues when wet, Speedcross 4 GTX is supposed to be more wet-condition friendly due to having the Gore-Tex technology. The lug pattern has also been redesigned to improve the grip and traction on wet, slippery terrains.
In usage, Speedcross 4 GTX is indeed more resistant to wetness and splashes. It does not immediately become drenched and slippery. Your feet can stay dry and happy as long as the water does not get to the top of the shoes. This is an improvement to be appreciated.
Unfortunately, the performance on wet and slippery terrains is not significantly improved. Yes, the grip and traction feel relatively better than the original model, but it is still not very powerful. You still have to climb very carefully during in such conditions.
The other features are still similar. Speedcross 4 GTX also comes with the quick lace system for easy take on and take off. This may be an inconvenient thing for those who hate the inability to adjust the fit with a single tug.
- The fourth generation of our legendary Speedcross lug pattern is an even hungrier monster for eating up soft, technical trails.
- Feel one with the trail with a precise combination of Sensifit with Quicklace, performance last shape and endoFit.
- Aggressive Grip: The fourth generation of our legendary Speedcross lug pattern is an even hungrier monster for eating up soft, technical trails.
Between Speedcross 4 vs Speedcross 4 GTX, we recommend you to choose Speedcross 4 GTX. This model comes with the Gore-Tex technology, which allows for significantly better water resistance. The outsole has also been improved, although not significantly.


I've had this one in my cellar for quite a while now and thought it was time to crack it. Couldn't wait any longer 🙂 Nice garnet in color with a lovely varietal rustic nose along with some typical barnyard, earthy hints. On the mid palate the wine displays some lovely varietal pinot noir notes to match the nose. Soft red berries, rustic notes and the like. On the medium length finish the wine still has some lovely lively acidity and tannins. This is still a beautiful wine and could have cellared even longer. I would give it an 89+. It was $29.95 at the winery. Yumm.
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Whispering from the sea, an invitation comes from the sea breeze. The above is the catch phrase of the hotel, Shiojitei.
This international hotel has a total of 46 guest rooms, and all are smoke-free.
overlooking Toba Bay. This hotel may be used as the base for your sightseeing in Ise, Shima, and Toba.
(R) Modern Japanese twin-bedroom, that is completed in April 2012, has high quality associated with mixed Japanese and Westrn relaxation.
(L) A half private dinning place (M) Cuisine menu (R) The Japanese foods continue in a sophisticated style.
These photographs show the open-air Pearl-Aurora-bath, that will turn your skin into 'Pearl skin' shining like powder of pearls.
Copyright (C) 2017 Junhaku Miyamoto All right reserved.
3. Be quiet during bathing.
The article was written in April 2017.
All photography was taken by Dr. Junhaku Miyamoto in April 2017.


AbtracOnLine will link to your accounting package via the API (application programming interface) supplied by your accounts software.
An API is essentially a doorway through which Abtrac can enter and deliver your invoice information. In some instances we can also link and update your contacts, projects and other information. What we are able to automatically synchronise is defined by your accounting package API.
If your accounting package doesn't have an API, or if it restricts the information that AbtracOnLine is able to create, then we can also link and export information via .csv files.
Unlike the API doorway the .csv link is two step process. A suitable invoice upload file is created from Abtrac and saved in a folder to your desktop, dropbox etc. This file is then accessed from your accounting software and uploaded using your accounting software's import function.
Tax Codes and Account Numbers are assigned to every Abtrac invoice.
Each invoice (and each invoice line) in Abtrac will need to have both a tax code and an account code that matches those in your accounting system.
In some instances the Client and Projects will also need to match, in other instances you can choose to simply create new clients in your accounting system based on the address details from your Abtrac invoices.
These Tax Codes and Account Numbers are applied to each and every Invoice from details specified in your Accounts Interface settings which are linked to the AbtracOnLine Invoice Settings.
An invoice setting can only be associated with a single accounts interface.
All offices may share one accounting interface setting.
It's also possible to have multiple accounts interfaces, and send your invoices to different accounting packages, or different accounts files.
Once you have both an Office and Invoice Setting created in Abtrac for an API connection you can choose Accounting Interface Settings from the Top Menu > Accounting > Interface Settings.
When an interface is created you can edit it's display name and associate it with an invoice setting, or edit other settings regarding the interface.
Is there a charge for the accounts integration add-on?
To determine whether there will be a monthly fee for your accounts link you can call the support team or try our pricing page with an online calculator. If a fee applies it's a flat rate of $15 per month. Charges apply based on the interface type and not the number of interfaces you have configured.
Once your accounts integration is set up this article on Using the Abtrac-Accounts link is also a useful read.
This entry was posted in Accounting Package Integration, Administration Settings, Getting Started, Invoicing and tagged accounting software, api, myob, upload invoices, xero by Jen. Bookmark the permalink.


text:
March (de Meij)
Dmitri Shostakovich (arr. Johan de Meij)
This article is a stub. If you can help add information to it,
please join the WRP and visit the FAQ (left sidebar) for information.
Subtitle: From Jazz Suite No. 2
Difficulty: IV-1/2 (see Ratings for explanation)
Original Medium: Orchestra
Publisher: Amstel Classics through Music Shoppe Europe
Cost: Score and Parts (print) - €127.00 | Score Only (print) - €24.00
E-flat Clarinet
B-flat Clarinet I-II-III
Trumpet (in B-flat) I-II-III
Baritone (Bass Clef & Treble Clef)
Basses I-II
Piano/Harp
Percussion, including:
N.B. Jazz Suite No. 2 is the title given to the 1994 Johan de Meij arrangement of Shostakovich's post-1956 Suite for Variety Orchestra. Despite the title, this arrangement is not related to Shostakovich's 1938 Suite for Jazz Orchestra No. 2.
Concordia University Chicago Wind Symphony (Richard R. Fischer, conductor) - Spring 2020
Pentagramma Winds (Cavalese, Italy) (Roberto Silvagn, conductor) – 15 November 2015
Allegro from "Symphony No. 10" (tr. Fisher) (1954/2010)
Batterie from "The Nose" (arr. Schaefer) (1928/1978)
Dance I. See under: Jazz Suite No. 2
Excerpts from "Symphony No. 5" Finale (arr. Longfield) (1937/2007)
Festive Overture (tr. Hunsberger) (1954/1965)
Festive Overture (tr. Martin) (1954/2016?)
Festive Overture (tr. Patterson) (1954)
Festive Overture (tr. Takahashi) (1954/1998)
The Fire of Eternal Glory (tr. Timothy Rhea) (1960/2011)
Fire of Eternal Glory (arr. Curnow) (1960/2011)
Folk Dances (tr. Reynolds) (1949/1979)
Folk Dances (arr. Erickson) (1949/1979)
Folk Festival (tr. Hunsberger) (1971)
Fortinbras March from "Hamlet" (tr. Suchoff) (1932/1967)
The Gadfly (tr. Patterson) (1955/)
Galop (tr. Hunsberger) (1959/1971)
Galop (from "The Limpid Stream") (tr. Miller) (1935)
Hamlet Suite (tr. Suchoff) (1964/1975)
Jazz Suite No. 2 (arr. de Meij) (post-1956/1994)
March (arr. de Meij) (post-1956/1994)
Lyric Waltz (arr. de Meij) (post-1956/1994)
Dance I (arr. de Meij) (post-1956/1994)
Dance II (arr. de Meij) (post-1956/1994)
Waltz No. 2 (arr. de Meij) (post-1956/1994)
Finale (arr. de Meij) (post-1956/1994)
March (arr. Curnow) (2014)
March (arr. de Meij). See: Jazz Suite No. 2
March of the Soviet Militia (ed. Iakubov) (1970/2006)
October, Op 131 (arr. Mitchell) (1967)
Overture on Russian and Kirg (arr. Janssen)
Overture on Russian and Kirghiz Folk Songs (tr. Duker) (1963/1989)
Overture to The Gadfly (arr. Geert Flik) (1984)
Piano Concerto No 2 (tr. Pontini) (1957/2012)
Piano Concerto No 2 in F Major (arr. Bamonte)
Piano Trio No. 2 (arr. Graham)
Priest and His Servant Balda, The (1934)
Prelude, Op. 34, No. 14 (arr. Reynolds) (1988)
Spanish Dance from "The Gadfly" (arr. Curnow)
Symphony No. 1 (Shostakovich) (tr. Scarbrough) (1924-25)
Symphony No. 5, Mvmt I (tr. Schaeffer)
Symphony No. 5, Mvmt II (tr. Smith) (1937/1944)
Symphony No. 5: Finale (tr. Righter) (1937/1947)
Symphony No. 5, Mvmt IV (tr. Rogers) (1937/2003)
Symphony No. 5, Mvmt IV (tr. Bocook) (1937/2005)
Symphony No. 9 (arr. Mertens and Suykerbuyk) (1945/1986)
Symphony No. 9 (tr. Schaefer) (1945/1976)
Symphony No. 10, Mvt. II (tr. Fisher) (tr. Fisher) (1954/2010)
Symphony No. 10, Mvmt II (tr. O'Brien) (1954)
Tahiti Trot (tr. Brubaker) (1927/2009)
Two Scarlatti Pieces (1928)
Waltz No. 2 (arr. Connery) (post 1956/1996)
Waltz No. 2 (arr. Curnow) (post 1956/2010)
Waltz No. 2 (arr. de Meij). See under: Jazz Suite No. 2
Sostakovich, D.; de Meij, J. (1995). March : From Jazz Suite No. 2 : For Symphonic Band [score]. Amstel Music: Amsterdam.
Retrieved from "https://www.windrep.org/index.php?title=March_(de_Meij)&oldid=154603"


Gilas Pilipinas Latest News & Updates. Gilas head coach Chot Reyes announced on twitter that Gilas resumes training for Fiba Qualifiers on Monday (January 8) for the second window of the FIBA Basketball World Cup 2019 Asian Qualifiers.
The Philippines(2-0) are in Group B with Australia(2-0), Chinese Taipei(0-2) and Japan(0-2). They travel to Melbourne to face Australia at the Margaret Court Arena on February 22 and then host Japan at the Mall of Asia Arena on February 25.
Just got clearance from PBA OIC Willie Marcial for Gilas to start its Monday only practices on Jan 8, 8pm. Back to work Blur, Kief, Kev, Jio, Pogs, Matt, Allein, Gabe, Calvin, CBC, Mac, Troy, Rakenrol, Japet, JMF #💪🇵🇭❤!


Some sources of iNews reported that John Arne insisted that Steven Gerrard would be the ideal candidate for the job of Liverpool after Klopp will move on. He added "Steven has often discussed to me about his long-term vision of his career. And he discussed all these with me before being associated with the Glasgow Rangers." He said that Steven has said to him that if he will get a good team and a co-operative group of directors behind him, then he can turn the tides at Rangers." So I think he can do the job for Liverpool very well and seems to me to be the perfect candidate for this stint. He also admired Steven Gerrard style of captaincy while he was with the Liverpool.


text:
Home / Blog / Latest news / PSC's email poll gives voters the views of over 1,000 candidates on Palestine
PSC's email poll gives voters the views of over 1,000 candidates on Palestine
In Latest news, Press Releases and Statements
General ElectionSarah Colborne
The issue of justice for Palestine will not be far from the minds of many voters going to the polls today.
Before they head to the ballot box, they will have been able to check their candidates' views on Palestine thanks to an extensive survey carried out over the last three months by Palestine Solidarity Campaign (PSC).
In the biggest poll of Parliamentary candidates conducted by a Palestinian rights organisation, PSC has gathered the views of more than 1,000 candidates on a series of questions relating to Palestinian human rights.
In England, Scotland and Wales, candidates have given their opinions on issues ranging from whether Israel should immediately lift its blockade of Gaza to whether the next UK government should impose an arms embargo on Israel until it abides by international law.
Their answers can be found on PSC's website, providing voters with an important resource as they go to vote.
Sarah Colborne, Director of Palestine Solidarity Campaign, said: "We've provided open and transparent information to voters on where their candidates stand on justice for Palestine.
"The reason for doing so is because people have told us they want to know which candidates support Palestinian human rights before they go out to vote."
Ms Colborne added: "The results of our email poll are looking good, and indicate that many incoming MPs understand the issues around Israel's occupation of Palestinian land, including Israel's disregard for international law.
"The challenge is to ensure that they uphold those fundamental principles of human rights and international law once elected to Parliament."
This media release was sent to national and international media on Thursday 7 May.
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Homepage > Catalog > Romance Languages > Portuguese Studies
The Theme of Loneliness as Treated by Maria Judite de Carvalho, Maria Ondina Braga, Teolinda Gersao and Helia Correia
Term Paper, 2012
7 Pages, Grade: 65
L H
Laura Smith (Author)
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Discuss the theme of loneliness as treated by Maria Judite de Carvalho, Maria Ondina Braga, Teolinda Gersão and Hélia.
Loneliness is a major health concern, a debilitating condition and a universal human emotion. It at once fascinates and terrifies us, which makes it an invaluable literary theme. The lonely and the elderly are often synonymous; Portuguese authors known for their short stories, such as those above, invariably include among their works an 'old woman' story in some form. The theme of loneliness comes as part of the package. The ways in which the narrative incorporates it, however, are as varied as the narratives themselves.
No stranger to such an emotion, Maria Judite de Carvalho's Mariana in Tanta Gente, Mariana is, contrary to the norm, not elderly when she dies and is in fact only fifteen in one section of the narrative. Her situation also stands out due to her loneliness stemming not from bereavement and consequential solitude, but mainly from persecution received due to social prejudices.
The ironic title, 'So many people, Mariana', suggests as much. The line from which it comes is seminal: 'We are all lonely, Mariana. Lonely and with so many people around us. So many people, Mariana!' As well as the title of this novella, it is the title of the book of stories and, incidentally, the only story title of the collection in question which contains a name. Thus the reader can more easily identify with the protagonist and one of the main themes, which is, according to Ana Raquel Lourenço Fernandes, 'solitude as an intrinsic part of the human condition.' (2008:138). Ana Paula Fernandes (unknown:1) agrees that Carvalho's work contains great 'densidade emocional' of this kind but goes on to stress that it is in particular the woman who is 'sublinha a solidão' and that the female soul remains 'isolada no grupo humano'.
Indeed it seems that Mariana suffers for her gender. Her former husband, António, leaves her for another woman but it is she, the divorced woman, who is forced to bear the scorn of others: 'Senhor Bruno has requested me to ask you to leave the company before any further scandal is caused'. Here Carvalho criticises the weakness and cowardice of people; the boss wants her out but can't face telling her himself. She may be unmarried and pregnant, no-one knowing the father, who is in fact her friend, Luís Gonzaga. Again, he remains blameless, though he's going away to be a priest. He, too, removes Mariana from his life and expects her to cry, which causes her to question the 'vanity of men, the incredible, ridiculous vanity of men'. This comment could arguably be one from Carvalho herself; the first-person voice, unique among these stories, provides some instances of commentary.
Why then does Carvalho choose such a pessimistic tone and central theme of loneliness? A tone which Telma Aparecida Malfa calls one of 'pessimismo, amargura e solidão'? (2007:99). Malfa suggests that the novella and its pessimistic view on the female condition in Portugal is a 'crítica social empreendida pela autora'(2007:99), a key idea in Carvalho's work. As mentioned, she critiques the attitudes of the people, especially men, towards Mariana and examines Portuguese society in general through the protagonist's plight. Fernandes (2008:138) remarks 'The short story is significant for its narrative structure... its shifts between past and present.' The fragmented narrative certainly shifts in time rapidly, forcing the reader to work in order to keep up. Fernandes (unknown:2) would say that 'o vaivém entre o pasado e o presente evidencia o drama existential da protagonista'. The reader is aware that Mariana was always a victim of circumstance due to her being a poor, uneducated woman: 'a simple typist, penniless and with no family'. In addition, the narrative's circular nature reveals the imminent death of the protagonist from the beginning and ends with the realisation of the event. This is the only type of 'resolution' allowed by Carvalho; to offer a 'happily ever after' or to afford Mariana some absolution would possibly counteract the social judgement. Malfa (2007:100) concurs that 'Maria Judite de Carvalho não tentar solucionar-lhes os conflitos e também não se preocupa em justificá-los.' Carvalho doesn't need to justify the extreme isolation of her protagonist because there is no justification. She doesn't resolve the situation because, in reality, there is no solution, only eventual death.
Similarly, in another of Carvalho's short stories, 'The Inconsolable Fiancée', the young protagonist Joana is isolated and lonely. It seems to be a common theme of Carvalho's; Raymond S. Sayers (1966: 264), who claims she is 'the most gifted of all the new short story writers', states simply that Carvalho 'writes about lonely women'. Without doubt Joana is one of these women; the reader is aware she has lost her fiancé, though it is not stated outright: 'He had planned to go to the beach with some friends...he had gone. That's all she knew. That's all anyone knew'. The worst is assumed, and arguably made more poignant for its lack of announcement.
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The first two sentences focus your readers' attention, but the statement that portuguese short story writers invariably inlcude an "old woman" story is somewhat sweeping. Four authors is not the broadest sample. Good use of quotations from source texts and secondary materials, eg. Hanson on the "Alienated vision of women". Reads well and demonstrates that you have understood and engaged with the stories.
Portuguese Literature, Portuguese Short Stories, Maria Judite de Carvalho, Maria Ondina Braga, Teolinda Gersao, Helia Correia
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Laura Smith (Author), 2012, The Theme of Loneliness as Treated by Maria Judite de Carvalho, Maria Ondina Braga, Teolinda Gersao and Helia Correia, Munich, GRIN Verlag, https://www.grin.com/document/295715
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Frontiers in Clinical Drug Research: Anti-Infectives
Editor(s) : Atta-ur-Rahman
DOI: 10.2174/97816810815331160201
eISBN: 978-1-68108-153-3, 2016
Back Recommend this Book to your Library Cite as
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Cite this Book as:
Atta-ur-Rahman , " Frontiers in Clinical Drug Research: Anti-Infectives ", Bentham Science Publishers (2016). https://doi.org/10.2174/97816810815331160201
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Table of Contents About Book
Book Volume 2
Page: i-i (1)
Author: Atta-ur-Rahman
Page: ii-iii (2)
Recent Advances in Novel Antibacterial Development
Page: 3-61 (59)
Author: Alberto J. Martín-Rodríguez, Héctor Quezada, Gabriel Becerril Aragón, César de la Fuente-Nuñez, Israel Castillo-Juarez, Toshinari Maeda, Valentina P. Salovarova, Thomas K. Wood and Rodolfo García- Contreras
PDF Price: $15
Bacterial infections remain one of the leading causes of death worldwide, and the options for treating such infections are decreasing, due to the rise of antibiotic-resistant bacteria. In fact, the continuing rise of antibiotic resistance is such a major global health concern that the World Health Organization has warned that we may enter a "postantibiotic era" within this century, and they propose that urgent actions should be taken. Nevertheless, since the pharmaceutical industry has not produced a new class of antibiotics for more than a decade, researchers are taking several approaches towards developing new classes of bacterial anti-infectives, including focusing on new targets and processes, such as bacterial biofilm formation, that is related to approximately 65% of human infections. Moreover, significant advances have been made in the development of therapies aimed to attenuate the damage produced by bacterial infections by the downregulation of bacterial virulence instead of directly targeting bacterial growth, in contrast to conventional antibiotics. Furthermore, other active research areas are the utilization of molecules produced by commensal and mutualist bacteria as antibacterials to inhibit the growth of pathogenic species, and to boost the immune system in order to promote the elimination of infections. Other alternative treatments are focused on inhibiting bacterial multidrug resistance mechanisms, such as the active efflux of antibiotics by multidrug efflux pumps. In this chapter, we discuss the recent advances in the development of novel bacterial anti-infectives, analyzing their anti-infective mechanisms, their activity in vitro and in vivo, and the advances toward their clinical implementation.
Antibiotic Resistance: Global Trends, Policies, and Novel Solutions
Page: 62-94 (33)
Author: Balagangadhar R. Totapally and Andre Raszynski
Antibacterial agents such as sulfonamides, penicillin, and streptomycin became available in the 1930s and 1940s and were quickly adopted into clinical practice. It was noted early on that bacteria, when exposed to antimicrobial agents, rapidly developed strategies to resist them. Penicillin resistance in Staphylococcus aureus was detected as early as in 1945. From the 1950s onwards, a large number of antimicrobial drugs became clinically available and had a major impact on the treatment of infections. Most recently, bacterial antibiotic resistance has grown exponentially along with the increasing use of antimicrobial agents, while at the same time the development of new antimicrobial agents has decreased dramatically. This has led to major global crises of infections with drug-resistant microbes, increased morbidity, and mortality, and increased health care costs.
Antibiotic resistance results from mutations or acquisition of new genes in bacteria that reduce or eliminate the effectiveness of antibiotics. According to the CDC, every year more than 2 million people in the US develop an illness due to antibiotic resistant bacteria and 23,000 of them die. There are multiple reasons for the development and spread of antibiotic-resistant bacteria. Overuse and inappropriate use of antibiotics are prevalent in clinical practice. The spread of resistant bacteria in hospitalized patients raises grave concerns for increased local antibiotic resistance. Non-human use of antibiotics for animal growth promotion is a major cause of development of global antibiotic resistance.
A multifaceted approach is needed to detect, prevent, and control antibiotic resistance at local, national, and global levels. The National Action Plan for Combating Antibioticresistant Bacteria was developed by the CDC, and it provides a roadmap to guide the US in rising to this challenge. Implementation of antimicrobial stewardship programs, diligent surveillance for resistant bacteria, rigorous implementation of infection control practices, restriction of antibiotics for non-human and non-infectious purposes are needed to combat the growing threat of antibiotic resistance. Another important strategy to counter the menace of antimicrobial resistance is to develop new antibiotics with novel mechanisms of action.
This chapter describes the global threat of antibiotic resistance, the mechanisms of development of antimicrobial resistance, the major causes of increased incidence of this problem, and the possible local, national, and global solutions to fight the scourge of antibiotic resistance.
Drug Safety Approaches in Anti-Infective Drug Discovery and Development
Page: 95-136 (42)
Author: Lucila I. Castro-Pastrana, Paola Serrano-Martínez and Lenin Domínguez- Ramírez
Anti-infective agents are some of the most widely used therapeutic drugs worldwide. Overall, the most common serious adverse events attributable to antiinfective agents include liver injury, nephrotoxicity, hypersensitivity reactions, cardiac arrhythmias, drug-drug interactions and therapeutic failure. In clinical practice, serious problems of toxicity limit the usefulness of antimicrobial drugs.
In order to improve the design of clinical trials and better conceptualize research plans for the development of anti-infective drugs, it is important to take into consideration cutting-edge drug safety approaches that can be implemented during discovery and early phase studies, as well as promising methods and models for clinical research advancement. In the present text, we describe a holistic perspective inspired by chemoinformatics, systems biology, and predictive clinical pharmacology, to discuss the utility of in silico methods, preclinical models, genomics, translational biomarkers and postmarketing surveillance strategies for safety evaluation and risk detection during anti-infective drug development.
Topical Antimicrobials: Classification and Performance
Page: 137-150 (14)
Author: Daryl S. Paulson
Since the discovery by Semmelweis that washing hands with chlorine decreased morbidity and mortality rates, the antimicrobial products market has grown tremendously. This chapter provides a brief introduction to the topical antimicrobial products currently on the market, how they are classified, how they work, and the purposes for which they are best suited. Among the first products used as a surgical scrub was an iodine complex (a tincture of iodine and an aqueous iodophor), which provides excellent immediate antimicrobial action. Another product, Chlorhexidine gluconate, which was first synthesized in 1950, has proved to provide high levels of antimicrobial activity and considerable effectiveness in healthcare personnel handwash applications. Alcohol and alcohol compounds also provide effective immediate effects but little to no residual or persistent activity. As the market has developed and scientific knowledge increased, product manufacturers have greatly improved product formulations, including the development of products containing quaternary ammonium compounds, which are used in household cleaners, disinfections, skin and hair care formulations, sanitizers, sterilizing solutions for medical devices, and even preservatives; parachlorometaxylenol product formulations are used primarily for healthcare personnel handwashes, as they are effective in removing transient microorganisms from the hands and have low skin irritation potential; and triclosan, which has fair immediate and persistent antimicrobial ability, but no residual action, has been formulated for a wide range of applications, including the food industry and consumer product lines. New products are constantly being formulated, tested, and brought to the market, according to the guidelines of the Food and Drug Administration.
Identification of Nosocomial Pathogens and Antimicrobials Using Phenotypic Techniques
Author: Marie Horká, Anna Kubesová, Dana Moravcová, Jiří Šalplachta, Jozef Šesták, Marie Tesařová and Filip Růžička
Nosocomial infections caused by multidrug-resistant strains increase morbidity and mortality in hospitalized patients, prolong hospitalization, and they have significant negative economic impact. Currently, nosocomial infections are included in a broader concept as healthcare-associated infections. These are caused by a wide variety of pathogens, typically Staphylococci, Enterococci, Pseudomonas aeruginosa, Klebsiella spp., Escherichia coli, etc. Certain fungal agents, e.g., yeasts of Candida genus and aspergilla, are also associated with these infections. The situation is further complicated by the development of resistance in the gram-positive cocci such as staphylococci or enterococci to second-line antibiotics used for the treatment of gramnegative bacteria and resistant gram-positive bacteria. Pathogenesis of mentioned infections plays a key role in forming biofilms on artificial surfaces.
Rapid detection and identification of etiological agents of nosocomial infections and determination of antibiotic susceptibility of pathogens are required for the optimal therapeutic scheme. Chromatographic methods such as high performance liquid chromatography or liquid chromatography-mass spectrometry are universal techniques widely applied to this purpose. However, only capillary electrophoretic techniques are able to determine both, antibiotics and microorganisms, during a single analysis. Differences in the chemotaxonomic fingerprints of the microorganisms can be utilized by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. In this chapter, we would like to outline an overview of available analytical techniques capable of rapidly identifying and estimating levels of antibiotics as well as microorganisms in real samples with a focus on nosocomial infections.
Antimalarial Herbal Medicine: From Natural Products to Drug Molecules
Author: Norma Rivera Fernández and Perla Y. López Camacho
Malaria is still the most important parasitic disease in the world. Traditional medicines have been used to treat malaria for thousands of years and are the source of artemisinin and quinine derivatives. With the increasing levels of drug resistance, the high cost of artemisinin-based combination therapies and fake antimalarial drugs, traditional medicine has become an important and sustainable source of malaria treatment in endemic areas. The use of herbal medicines believed to have therapeutic properties is becoming increasingly widespread. These remedies are usually taken by patients on their own initiative without prescription from a physician. The discovery and use of natural compounds require a thorough investigation of their safety and efficacy before their release into the market because herbal medicines present the greatest risk of adverse effects relative to all complementary therapies. Nevertheless, natural products have been a major source of new drugs due to the high diversity of their natural compounds that often provide specific biological activities. In this chapter, we review the results achieved in the use of extracts, fractions and compounds obtained from natural sources that have antimalarial efficacy. We also provide a panoramic view of the updated literature on the challenges and strategies associated with contemporary antimalarial natural drug research.
Drug Delivery Systems for Vaginal Infections
Author: Sandra Borges, Joana Barbosa and Paula Teixeira
Vaginal infections are one of the most common gynecological problems. The lower female genital tract can be infected by various pathogens such as virus (human immunodeficiency virus, HIV), bacteria (Gardnerella vaginalis), fungi (Candida spp.) or parasites (Trichomonas vaginalis).
The vagina is the local site for the delivery of therapeutic agents. Depending on the antimicrobial agents, different dosage forms have been developed, comprising of douches, creams, ointments, gels, foams, tablets, ovules, rings, tampons and, more recently, vaginal films. Innovative approaches, like encapsulation technologies, have emerged in an attempt to overcome several limitations of the existing systems for vaginal administration of therapeutic agents.
This review explores the antimicrobial agents that can be used for vaginal infections therapy, the various vaginal dosage forms to deliver these therapeutic agents, their advantages and limitations and the novel advances in the area of vaginal drug delivery.
Frontiers in Clinical Drug Research – Anti infectives is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the eBook series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research – Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti-infective drug discovery and epidemiology. The second volume of this series features reviews that cover a variety of topics including: -Identification of nosocomial pathogens and antimicrobials using phenotypic techniques -Topical antimicrobials -Anti-infective drug safety -Antimicrobial resistance … and much more.
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Rose Sweetly is computer. She has gift for mathematics and works for an Astronomer, working out the complicated computations necessary to track the transit of Venus. She is incredibly passionate about her work and thrilled to do it even if it is in a secondary position. Stephen Shaughnessy is writer, the author of a popular and outrageous column in woman's paper called "Ask a Man" and Rose's neighbor.
Rose has captured Stephen's attention and despite knowing he shouldn't pursue it he does. No longer content with moments of snatched conversation on the street, Stephen pretends to be doing research on a book on astronomy and arranges with her employer for Rose to tutor him on the necessary maths. Rose is wary but secretly delighted to spend time with him, even though she knows that there is can be no future for them. Typically a shopkeeper's daughter and stable master's son would not be too far from each other in social class in Victorian England, but Rose is black and Stephen is white Catholic Irish and a romantic relationship would make them the object of gossip or scandal.
The novella explores two major intertwined themes of seeing and knowing. Rose and the whole Astronomy community are preparing to watch the transit of Venus across the Sun in hopes that they can use the measurements they take to better estimate the distances between other heavenly bodies. They will use what they see to know the heavens.
When Rose's sister Patricia sees her talking to Stephen on the street just outside their home, she warns her that white men will not see her brilliance, her cleverness, but only see the color of her skin. When Stephen talks to her employer, he recognizes her usefulness to him, it is clear that he only see her as woman and not someone with as much or even more aptitude to astronomy as he does. Stephen feels he sees Rose like no one else does, he recognizes her brilliance and knows she has bigger dreams that she will ever acknowledge and wants to help her achieve them.
Rose also see Stephen, she sees past his facade of frivolous charm, his jokes and good humor, to his hurts, his compassion and honor, to see a man better than his outrageous reputation. Stephen doesn't intend to seduce her, but his actions constantly work as a seduction, opening Rose's eyes to his value and worth. But despite Stephen's good intentions and his behavior toward her Rose fears that he has only the barest idea of how hard it would be for them, and she can't trust that love and good intentions will be enough because she needs for him to see all of her, including her black skin and see how hard it will be for her as a black woman married to a white man.
In the end they both come to truly see and move beyond to trusting and knowing and I was fully satisfied with how Milan brought that about, it felt true to the story and more importantly true to Rose and Stephen. I highly recommend this sweetly romantic novella, that can be read and enjoyed without reading any of the other books in the Brothers Sinister Series.
A copy of Talk Sweetly to Me was provided by the author via NetGalley for review purposes.
This novella reminded me how much I enjoy working class period romances and that the only historicals that I have finished this year have either had people of color and/or non-aristocratic leads. Any one want to share their favorite non-Duke-and-ballroom historical recommendations, extra points for POC representation?


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East Bay water customers poised to get break on…
East Bay water customers poised to get break on rates
By Denis Cuff |
PUBLISHED: May 10, 2016 at 3:09 p.m. | UPDATED: July 28, 2018 at 12:32 p.m.
OAKLAND –The East Bay Municipal Utility District board on Tuesday is expected to scrap a 25 percent drought surcharge that added about $8 a month to the average household bill during the last 11 months of the drought.
Saying they have enough water this year, EMBUD's managers are urging an end to the drought surcharge effective July 1, and recommending going back to voluntary conservation.
The district imposed the surcharge on July 1 as an incentive for its 1.4 million customers in Alameda and Contra Costa counties to save. The surcharge raised some $50 million to buy additional water from near Sacramento and to pay for conservation efforts.
"We're saying we want to transition from a drought emergency to water-saving measures for the long haul," said district spokeswoman Andrea Pook. "We're OK for water supplies for a year or two, but we know we're going to have to continue to save in the long-term."
Ending the surcharge would shave about $8.08 off the water bill of an average household using 246 gallons per day, district officials said.
But average bills already are scheduled to go up $3.66 a month on July 1 in a general rate increase to cover inflation and stepped-up pipe replacement.
In the net effect of the two actions, the average bill would drop by $4.42 a month from $60.25 to $55.83 per month.
Pook said the proposal is in sync with Gov. Jerry Brown's announced plan Monday to do away with mandatory reductions for the state's more than 400 water districts.
The state last year ordered EBMUD to cut use 16 percent. District customers exceeded the target by conserving about 24 percent.
The water board meets at 1:15 p.m. Tuesday at its headquarters in Oakland.
Contact Denis Cuff at 925-943-8267. Follow him at Twitter.com/deniscuff or facebook.com/denis.cuff.
Denis Cuff
Crime & Public Safety |