A few weeks ago I was invited to speak at the International Government Communication Forum (IGCF) in Sharhaj, UAE, where this year's theme was "behaviour change".
One of the conference highlights for me was participating on a panel with Dr Abdullah Al-Maghlouth, Director- General of the Centre for Government Communication in Saudi Arabia; and Sir Craig Oliver, Director of Politics and Communications for the former UK Prime Minister David Cameron. The topic we explored was "Challenging the Lack of Capacity in an Era of Change Communication". We discussed everything from the need for digital literacy training to the major gap in foundational social marketing education among government communicators around the world.
It was neat to see how similar many of the challenges tend to be in various countries and more importantly, what has been effective in overcoming some of them. I have posted some of my slides on Slideshare, where I provide some tangible tips and examples of how a social marketing framework can be used to help government communicators be more effective in reaching their goals for any initiatives requiring societal behaviour change.


The stress of making plans, packing the essentials,Borse Chanel Outlet Online, getting into the airport on time,borse hermes, waiting to check in and the whole security scenario really pack a tough one-two psychological punch on the low back.
This bias exists for whatever reason real several imaginary good reasons why. If you are one such person, you make the choice of either adopting a rational approach or indulging yourself by getting into for a leather jacket only.
Dressing up pillows as a young adult's room can be very straight forward. Take some old clothes such as band shirts,gucci outlet, shirts with cool designs or an old but relevant pair of jeans; cut them to size match your decorative pillows and sew them together. Acquiring make an ideal personal accessory for any teenager's room, deliver their room a spot of personality.
But you ought to not be daunted one does want that redwood varieties of greenhouse. If you choose a prefabricated structure all you need to do is bolt the greenhouse assembled. The same is true of aluminum framed greenhouses. Precisely what people call on the skilled tradesman to invest the power and water supply,burberry outlet online.
Hot Water: Filling you will recognize that drain your water heater down unless you've planned for extra capacity. Discovered that the water for my pre bath shower isn't very warm once I've filled the bathtub.
When building the retaining wall alone, opt for interlocking obstructs. Take care to refill the ditch or trench right after the base or footing or foundation layer carried out.
There aren't an gains without pains: Getting this done something means giving up something. Reading an instructive book means giving up watching a tv show. Saving cash means not spending it on something you feel the need. No pain,burberry outlet italia, no gain.
One more tip- Great places to partake in to find items to offer are rummage sales. You can usually find some really discounted prices at rummage sales. Buy the products take them home and list them on web sites,burberry outlet.


text:
Hair Styles, Red Carpet Fab
Red Carpet Hair Fab – 2018 Grammy Awards Edition
As the award season continues, Sunday's 2018 Grammy Awards was another disappountmet in the hair game. No offense, the hair game was seriously lacking. There were some really nice styles, true, the messages powerful which is what is important but the hair though… sigh!
Say No to the Hair… was not feeling any of the styles below
NEW YORK, NY – JANUARY 28: Recording artist Rito Ora attends the 60th Annual GRAMMY Awards at Madison Square Garden on January 28, 2018 in New York City. (Photo by Lester Cohen/Getty Images for NARAS)
NEW YORK, NY – JANUARY 28: Recording artist Andra Day attends the 60th Annual GRAMMY Awards at Madison Square Garden on January 28, 2018 in New York City. (Photo by Lester Cohen/Getty Images for NARAS)
NEW YORK, NY – JANUARY 28: Recording artist Cardi B attends the 60th Annual GRAMMY Awards at Madison Square Garden on January 28, 2018 in New York City. (Photo by Lester Cohen/Getty Images for NARAS)
Janelle Monae, Rita Ora, Andra Dray (Chiquita is loving her 50's styles) Cardi B (not all up-dos is a must), Jaden Smith, Lil Uzi Vert and Sza (like the dress).
The passables of the night, the styles are good but were not my fave
NEW YORK, NY – JANUARY 28: Recording artist Ledisi attends the 60th Annual GRAMMY Awards at Madison Square Garden on January 28, 2018 in New York City. (Photo by Steve Granitz/WireImage)
Ashanti, Chrissy Teigen, Eve, Ledisi, Rapsody, Sheinelle Jones and Tiffany Reid
Faves of the night.
NEW YORK, NY – JANUARY 28: Recording artist India Arie attends the 60th Annual GRAMMY Awards at Madison Square Garden on January 28, 2018 in New York City. (Photo by Kevin Mazur/Getty Images for NARAS)
NEW YORK, NY – JANUARY 28: Alicia Keys poses in the press room during the 60th Annual GRAMMY Awards at Madison Square Garden on January 28, 2018 in New York City. (Photo by Michael Loccisano/Getty Images for NARAS)
eDionisio D4s
NEW YORK, NY – JANUARY 28: Recording artist Tina Campbell attends the 60th Annual GRAMMY Awards at Madison Square Garden on January 28, 2018 in New York City. (Photo by Dimitrios Kambouris/Getty Images for NARAS)
Rihanna, India Arie, Alicia Keys, Beyonce and Tina Campbell
NEW YORK, NY – JANUARY 28: Former NFL player Victor Cruz attends the 60th Annual GRAMMY Awards at Madison Square Garden on January 28, 2018 in New York City. (Photo by Lester Cohen/Getty Images for NARAS)
NEW YORK, NY – JANUARY 28: Comedian Trevor Noah attends the 60th Annual GRAMMY Awards at Madison Square Garden on January 28, 2018 in New York City. (Photo by Lester Cohen/Getty Images for NARAS)
Big Sean, D.R.A.M, Donald Glover, Gary Clark Jr., Victor Cruz, Khaled, Rick Ross, Robert Randolph, Trevor Noah and Common.
Photocredit: Eonline, BellaNaija, theYBF
Published by naturalhairchiquita
View all posts by naturalhairchiquita
Previous postBlack Women in the Victorian Era
Next postRed Carpet Hair Fab – Black Panther World Premiere…Wakanda Forever

redpajama_set_name: RedPajamaCommonCrawl


Glyphryns are the chemical that build up Glyphrynphx . They are made up of an unknown and an unstable element. Scientists are still trying to discover the element. Glyphryns can also attack the brain if you go past the limit of 100 Ryns.
"Your Glyphryns are attacking your brain"
Get a Glyphryns mug for your daughter-in-law Beatrix.


Americans feel the pressure of mounting student loan debt. In fact, one in seven have postponed getting married because of it, while 44% of college-educated people have put off buying a house.
That's why you don't want your student loan debt to linger around forever. With the right repayment strategy, guidance, and self-motivation, you can tackle your debt and save yourself a headache. Read on to learn the best ways to get rid of your debt and save thousands of dollars on your student loans.
Check your cash flow. Do you know where your money is going each month? Are there holes in how you spend or manage your money that need to be patched? Focus on these spots. Your cash flow analysis will be your primary guide for choosing a repayment strategy.
Choose a repayment strategy. If you're making only the minimum payments, you're doing it wrong — paying the minimum leaves you locked in debt for years. Instead, use the debt snowball or debt avalanche method to make extra payments.
With a debt avalanche, you pay off the loans with the highest interest rates first and pay only the minimum on the rest. Repeat with the next-highest rate loan and work your way on down.
Or try a debt snowball by focusing on paying down the loan with the lowest balance first. Once your first loan is paid off, repeat with your remaining loans and make your way up to the largest. Then, prioritize private student loans, since they usually these have higher interest rates and stricter payment terms.
You'll reduce interest by getting a fresh loan with a lower interest rate, so you'll pay less money overall. Check out this list of student loan refinancing lenders that save borrowers an average of $14,000 - $17,000 over the lifetime of repayment.
You can also lower your monthly payments. This is a good option if you haven't gotten the hang of budgeting since it can reduce how much you pay each month.
Keep in mind, though, that by refinancing a public loan — essentially, turning it into a private loan — you could be giving up benefits like loan forgiveness.
Avoid income-driven repayment programs unless you're really struggling to make your monthly payments. They lengthen the payment period, so it takes longer to finish, which often results in more interest payments.
Find forgiveness and repayment assistance. Getting student loan forgiveness is like winning the student loan lottery: It's free money to pay off your debt. You can apply to have some of your student loan debt wiped away if you're working in public service or specialized career fields like medicine, education, and law.
Go one step further with a cash windfall. Nabbed a hefty inheritance? Apply that to your loan payment. Tax refund? Loan payment. Birthday check from Grandma? Loan payment. (You get the idea.) While it's tempting to spend this "found money," you really should put any surprise cash toward your loans, letting you periodically knock off big chunks from your balance.
Start a side hustle. Earning money on the side can make a huge dent in your student loans over the long term. It doesn't haven't to be anything drastic, either. Start out small and try to earn just an extra $200 per month as a brand ambassador, Uber driver, or freelance writer for example.
No matter what strategy you decide to take, Student Loan Hero can help you create a personalized plan of action, putting you one step closer to a debt-free life.
This post is a sponsored collaboration between Student Loan Hero and Studio@Gawker.


The German family-run business has enduringly shaped the amusement industry like no other. New and innovative rides that delight people are constantly being developed. Every day more than one million people all over the world sit in a ride developed and built by MACK Rides in Waldkirch.
Anyone entering the company building in the small town of Waldkirch soon gets a sense of the inventive spirit and real passion for speed and technology ever-present in this bright and modern space. What once began as a small craftsman's business has evolved into a smart global player of international standing that has nonetheless retained its down-to-earth credentials.The medium-sized company still builds every single ride individually here in Waldkirch before shipping them around the globe. Take a look around and learn about our newest innovations, get to know us and contact us to let us inspire you for your next project.
The Karlsruher Institut für Technologie is hosting the annual Maschinenbautag on July 14th, 2017. As a proud sponsor of the KIT also MACK Rides is presenting exciting details about our work and the job as an engineer.
Visit us at EAS 2017 in our capital city Berlin!
From Wednesday, February 22nd you can find our booth at IAAPI expo in Mumbai. Stop by booth C11 and find the newest ride ideas for your theme park.


text:
Gustakh Dil
Gustakh Dil 29th April 2014 Written Episode Update
By Amena	 Last updated Apr 29, 2014
Gustakh Dil 29th April 2014 Written Episode, Gustakh Dil 29th April 2014 Written Update
The Episode starts with Lajjo coming to the room. Nikhil asks what happened, husband had a bath and his hair are wet, will you serve me or not, come, dry my hair. She dries his hair with a towel. He holds her and they fall on the bed. He gets romantic. She hugs him and closes her eyes. She says I love you a lot. But I m afraid maybe you won't forgive me, I spoke to Barkha, you also talk to her. Teri khushi tumse judi……………..plays……………..She says I will not come with you. She then sees Nikhil sleeping. She kisses him. Mann bawra…………….plays…………
Lajjo is upset thinking about Barkha's words. Nikhil comes and hugs her. He smiles seeing her getting ready and applying sindoor. Nikhil says nice, but something is missing. He gives her the bindi, she puts
it. He says I was thinking that mum is gone, so its time for family planning, joking, we have to plan everything, I m thinking to go to Delhi and I will be back in few days and then we will see your college admission. Lajjo is upset and says we have to be separate for some time. Nikhil is shocked and asks why, did you change mind or did not lose trust on me.
She says I know, being away from you, I will always be in your heart. He says what mum said…….. She says she was right. He says are you coming Delhi to stay with me or mum. She says with you, but I promised her that I will come there after becoming something. He asks what do you mean. She says I will be something that people respect me. Nikhil asks I respect you from heart, is this not enough, did I insult you, I don't care what my family thinks. Lajjo says I will have to be in your society and you will be ashamed because of me. He says what is this rubbish, don't bring past in present.
He says I told you those things won't be repeated, I will take care of you and keep you happy, I argued with mum because of you, and you are backing off, no one cares about me, everyone are concerned about their wishes. Lajjo says try to understand, I know your problem, but you have to support me. Nikhil says what do you think, you will stay here and I in Delhi, will we be happy staying apart. Lajjo says this distance is necessary, I promise I will come back to you, else where will I go.
Nikhil says this is not done, what you want can't happen. She says I don't want your family to break because of me. He says I don't care what you talked to mum, this is not accepted, my decision is you will come with me to Delhi. He says I will not listen anything now. He leaves. Lajjo cries. Barkha tells everyone that Lajjo challenged that she will come here after becoming something. Inder asks about Nikhil. Barkha says he is in love, he said he will stay separate from us, in rented house, find a job. She says thank God that I went to Sonbarsa and did this. She says don't know what will Nikhil do after he comes here, I can't trust that girl. Maybe she will come with Nikhil.
Nani says no, if she said she will not come, then she won't. She says what you did is wrong. Barkha says I did what I wanted. Nani supports Lajjo and says what about Nikhil, he is not be happy here without Lajjo. Inder scolds Barkha. Ayehsa comes to meet Adhiraj and he is still annoyed. She tries to make everything normal. She asks what happened today, you are not angry on me today. Ayesha cries and talks about social acceptance which is very necessary. He argues.
He says I decided I will be like this and not care about society. Lajjo asks Putti did she see Nikhil anywhere. Putti says no. Lajjo runs to find Nikhil. Nikhil sits in the old fort thinking about Lajjo. Lajjo slips and says Nikhil ji save me. He runs to save her. He hangs. Nikhil comes to her and feels tensed. He holds her hand and lifts her up. He thinks how his brother died as he left his hand.
Barkha and Inder have an argument over Nikhil.
Balika Vadhu 29th April 2014 Written Episode Update
Beintehaa 29th April 2014 Written Episode Update
Tanjina 29th Apr 2014 - 9:56 pm
Thanx amena


Thank you to all the students, alumni and faculty that attended our tailgate for the Michigan vs. Wisconsin game. It was a beautiful day filled with great food and even better company. Not to mention a solid WIN for Michigan!


text:
Q: mysql query optimization I would need some help on how to optimize the query.
select * from transaction where id < 7500001 order by id desc limit 16

when i do an explain plan on this - the type is "range" and rows is "7500000"
According to the some online reference's this is explained as, it took the query 7,500,000 rows to scan and get the data.
Is there any way i can optimize so it uses less rows to scan and get the data. Also, id is the primary key column.

A:
online reference's this is explained as, it took the query 7,500,000 rows to scan and get the data

not actually. it's the approximate (optimizer cannot say the correct number in many different cases)  number of rows that potentially will be scanned. but you specified LIMIT - so only first 16 rows will be affected while query executed.
ps: i hope the used key in EXPLAIN is id?

A: I performed an explain with your query on a 8 million rows table
id   select_type  table       type  possible_keys  key      key_len  ref    rows     Extra
1   SIMPLE       transaction range PRIMARY        PRIMARY  8        NULL   4079100  Using where

The actual execution was fast, Execution Time : 00:00:00:044.

redpajama_set_name: RedPajamaStackExchange


text:
The NM Political Report (https://nmpoliticalreport.com/2020/01/27/solar-tax-credit-passes-first-committee/)
Solar tax credit passes first committee
By Kendra Chamberlain | January 27, 2020
Sen. Majority Whip Mimi Stewart's bill to reinstate a solar tax credit passed its first committee Monday with a vote of 8-2. Stewart, D-Albuquerque, presented SB 29 to the Senate's Corporations and Transportation Committee.
"I hate to count how many times the committee's actually heard [this bill]," Stewart joked with the committee. By our count, it's the fifth time the bill has been introduced since the state solar tax credit expired in 2016.
Stewart, who has been working on the bill with Gov. Michelle Lujan Grisham, said the two of them agreed that "this needed to be a bill that incentivized folks to use solar."
RELATED: Clean energy top of mind in 2020 legislative session
The legislation would create an income tax credit worth 10 percent of the cost of installation for solar thermal or solar photovoltaic systems for residential, business or agriculture applications.
The bill caps tax credits at $6,000 per person — down from the $9,000 that the initial tax credit offered — and sets a $10 million limit total per calendar year. The legislation would require individuals or businesses to apply for the tax credit in the tax year during which the system was purchased, and it specifies that only certified solar thermal or photovoltaic systems qualify. It also directs the state Energy, Minerals and Natural Resources Department (EMNRD) to develop rules for certifying solar systems for tax credit eligibility. The tax credit would expire in 10 years.
Stewart said 7,700 residences took advantage of the tax credit between 2008 and 2016. The tax credit expired after then-Gov. Susana Martinez pocket vetoed an extension in 2015. She pocket vetoed another solar tax credit proposal in 2018.
"Although the cost of solar has gone down incredibly, it's still expensive," Stewart said. "From the data we have, people who [install solar] have incomes of $30,000 to $90,000 per year. It ranges from lower income to the upper income."
Stewart also stressed that the tax credit would help bring more jobs to the state.
"When we lost our credit in 2016, we saw a 25 percent decrease in solar jobs in this state," Stewart said, adding that solar companies left the state as a result of the tax credit ending.
"This tax credit really is a job producer," she said.
Sen. Pat Woods, R-Broadview, voiced concerns about the bill. He acknowledged that rooftop solar is good for the consumer, but said it might pose problems for smaller electric utilities in balancing power generation when the solar panels aren't generating power. Woods sits on the board of the Farmers Electric Cooperative servicing Curry, DeBaca, Guadalupe, Harding, Quay, Roosevelt and San Miguel counties.
"It's really a great thing for a consumer to not pay an electric bill. They make a huge investment. The bad part of that is, it's damn hard to figure out how much generation you need if you keep getting a lot of rooftop solar," Woods said. He pointed to situations of inclement weather where rooftop solar may not perform reliably.
"I'm sure that the grid is capable in a large area to take care of that," he said. "But the smaller the grid size, the more it complicates the [power] generation. It's a hell of a balancing act to do. And I can see why a utility, especially a small utility, would have problems."
He also expressed doubts that the tax credit would help the state's poorest.
The bill ultimately passed the committee, with Woods and Sen. William Sharer, R-Farmington, voting against it.
The committee also passed SB 6, sponsored by Sens. Steve Neville, R-Aztec, and Jacob Candelaria, D-Albuquerque. That bill would enable counties to issue industrial revenue bonds (IRBs) for funding transmission line projects across the state. The bill passed the committee with no opposition.
Both bills will head to the Senate Finance Committee next.
Mimi Stewart
New Mexico Solar Tax Credit
Pat Woods
President Joe Biden wasted no time in starting to tackle some of the country's most pressing climate change issues after being inaugurated on Jan. 20.
NMED beings PFAS cleanup without military help
Renewable energy bills on tap for the 2021 session
View all Environmental Project articles →
View all Quick Reads articles →
Scaled back budget heads to Senate
Over the objections of Republicans who wanted to cut more, House Democrats pushed through a scaled back state budget to shore up a $2 billion budget shortfall caused by the pandemic and oil price crash that devastated state coffers. The House approved the roughly $7 billion budget in a 46-24 vote along party lines, with Republicans opposing the budget plan.
Groups call on legislators to cap environmental budget cuts at 3 percent
Secretary of state pushes for temporary automatic mail election
View all 2020 Legislative Session articles →
Lawmakers poised to start a strange legislative session
The 2021 legislative session begins Tuesday at noon, against a bizarre backdrop that's never been contemplated, much less seen. The Capitol building remains surrounded by fencing, concrete barriers and blocked roads.
NM Senate Dems pick leadership, make choice for pro tem nominee
Senate sends budget to governor, adjourns
View all Mimi Stewart articles →
Winners and losers of the 2017 session
One of the biggest winners in the just concluded 60-day session of the New Mexico Legislature was a man who never set foot in the Roundhouse and, in fact, never came close to crossing the state border. His name is Donald J. Trump, the president of the United States.
Supporters want to know why solar tax credit extension was vetoed
Legislature votes to extend solar tax credits
View all New Mexico Solar Tax Credit articles →
KRQE reporter kicked out of Senate committee meeting
State senators kicked a television reporter out of a public committee meeting Thursday, telling her she was not allowed to film the hearing. Rachel Knapp, who covers the Legislature for KRQE-TV, was filming the Senate Conservation Committee's deliberations on a hazardous waste bill when Sen. Antoinette Sedillo Lopez interrupted the meeting to ask the reporter if she had permission to record.
Public records bills include secrecy on lottery winners
Senate passes tax package, bill to borrow money to balance budget
View all Pat Woods articles →
State looks to address Texas v. New Mexico water case
Senate prohibits firearms for big hearing on guns, cannabis
Kendra Chamberlain


text:
Q: highlight a node in tikz \begin{frame} {Family work up }
\begin{tikzpicture}[level 1/.style={sibling distance=5cm},level 2/.style={sibling distance=2.5cm}]
    \node {Patient}[edge from parent fork down]
        child { node {Daughter 32 years}}
        child { node {Son 28 years}}
        child { node {\color{red} {Daughter 23 years}}}
    ;
\end{tikzpicture}
\end{frame}

Hi
Above code produces a small family tree. I would like to highlight a child (Daughter 23 years) suggesting she also has got a disease. This can be done by encircling it with a box or highlighting it with a color. Kindly help.

A: You like to have something like this?

The code:
\documentclass[compress,final]{beamer}
\usepackage{tikz}
\usetikzlibrary{trees}

\begin{document}
\begin{frame}{Family work up }
\begin{tikzpicture}[
level 1/.style={sibling distance=3cm},level 2/.style={sibling distance=2.5cm}]
    \node {Patient}[edge from parent fork down]
        child { node {Daughter 32 years}}
        child { node {Son 28 years}}
        child { node[draw=red] {Daughter 23 years}}
    ;
\end{tikzpicture}

or

\begin{tikzpicture}[
level 1/.style={sibling distance=3cm},level 2/.style={sibling distance=2.5cm}]
    \node {Patient}[edge from parent fork down]
        child { node {Daughter 32 years}}
        child { node {Son 28 years}}
        child { node[fill=gray!30] {Daughter 23 years}}
    ;
\end{tikzpicture}
\end{frame}
\end{document}

Nodes in tree you can design as other nodes in tikzpicture, just add to them desired parameters, similarly as I do above. And by the way: sibling distance 5cm is to big that with it the tree can be fitted onto slide so I reduce it to 3cm.

A: Also, using the macro from Using beamer overlays with forest generated trees, to have two overlays:
\documentclass[compress,final]{beamer}
\usepackage{tikz}
\tikzset{
    invisible/.style={opacity=0},
    visible on/.style={alt={#1{}{invisible}}},
    alt/.code args={<#1>#2#3}{%
        \alt<#1>{\pgfkeysalso{#2}}{\pgfkeysalso{#3}} % \pgfkeysalso doesn't change the path
    },
}

\usetikzlibrary{trees}

\begin{document}
\begin{frame}{Family work up }
\begin{tikzpicture}[
level 1/.style={sibling distance=3cm},level 2/.style={sibling distance=2.5cm}]
    \node {Patient}[edge from parent fork down]
        child { node {Daughter 32 years}}
        child { node {Son 28 years}}
        child { node[alt={<2->{fill=yellow}{}}] {Daughter 23 years}}
    ;
\end{tikzpicture}
\end{frame}
\end{document}

With the result:


text:
BONNEE CRAWFORD EDITING
Affordable editing services
Category: Editing
Why Are There Different Types of Editing?
My last three posts have explained the differences between the three types of editing: content editing, copy editing, and proofreading. In these posts, I stressed the fact that each type of editing should be completed separately. But why is that? And why are they completed in such a particular order?
The main reason each level of editing ought to be completed separately is so the editor's efforts are focused.
Another important reason for each stage of editing to be completed separately is to prevent double-ups from occurring. For example, if an editor completes copy editing before or alongside content editing, they'll likely have to redo the task anyway. Content editing includes rewriting, rearranging, adding, and omitting text, which means if that text was copy edited already, all that hard work will be undone.
The separation of these tasks also means that an editor can focus on a specific set of elements without getting sidetracked. Editing structure and content takes a lot longer if the editor stops to think about every comma and dash along the way. Keeping the stages of editing separate makes it easier to do each job thoroughly, because the editor isn't trying to do too many things at once.
Another reason the three stages happen in this order is that, once a piece of work has been put in the design file, making changes like adding or removing words creates a lot more work for the designer than you might think. Keeping the stages separate ensures that each level of editing is completed thoroughly, without distraction, to minimise having to redo tedious work.
bonneecrawfordediting	Editing	Leave a comment Sep 28, 2019 Sep 28, 2019 1 Minute
Types of Editing: Proofreading
In my last two posts, I talked about content editing and copy editing. Today, I'll explain what happens in the final stage of editing: proofreading.
In most cases, this stage of editing comes after the designer has placed the work into a design file and completed the typesetting and formatting. If the text is being published on a blog or forum—like this post—proofreading can be done in 'Preview' mode, prior to posting. For print publications, the proofreader should print out a proof copy.
Once text is in a design file, it becomes a lot harder to make substantial changes. Major changes at this stage could alter the page count or require a rework of the layout to make it fit, which can be time-consuming. Therefore, things that ought to have been addressed during content editing should not be addressed during proofreading. So what does an editor do when proofreading?
The aim of proofreading is to ensure legibility, resolve page layout issues, and check that design choices are appropriate. Proofreading also checks that the instructions in a design brief have been followed. For example, the brief might instruct that new paragraphs are to be shown by leaving a blank line, text is to be aligned left and justified, and for page numbers to appear in the top left header of each page in hot pink 8pt Century Gothic font. Proofreading checks that all of these instructions have been followed and consistently adhered to.
Another important part of proofreading is cross-checking the proof with the copy edited version to ensure formatting—such as bold and italics—hasn't been lost and to make sure no text has gone missing. This is also the absolute last chance to catch sneaky typos that might have been overlooked during copy editing.
Attention to detail is vital because this is the final stage of editing before the text is published or printed. The author is usually not involved in this stage of editing. An editor will usually send a list of proofreading notes to the designer (or person in charge of the design file) to apply. Proofreading should happen several times over for best results.
bonneecrawfordediting	Editing	Leave a comment Apr 9, 2019 Apr 6, 2019 1 Minute
Types of Editing: Copy Editing
In my previous post, I talked about the first stage of editing which focuses on improving the overall structure and content of written work. Today, let me tell you about copy editing.
This stage focuses on editing at the sentence-level, eradicating errors in spelling, punctuation, grammar and usage. An editor will also correct issues in sentence structure and address consistency issues such as tense and spelling conventions.
Editors should have certain tools at their disposal during this stage, such a style sheet and a spelling sheet, where they can easily record words and names with unique or variable spelling and other stylistic preferences. Of course, they should also have a dictionary (or online subscription to one) handy, and a thesaurus never goes astray. Depending on the type of writing, an editor might also need a referencing guide or a specialised dictionary for a specific subject.
The author is usually not involved in this stage of editing unless the editor requires clarification.
It's important to note that when the work is being edited for publication, copy editing is the last chance to ensure everything is correct before it goes to the designer. Once the writing has been placed into a design file, it becomes harder to make changes. In other words, copy editing must be completed thoroughly to avoid potential problems later on.
bonneecrawfordediting	Editing	Leave a comment Apr 2, 2019 1 Minute
Types of Editing: Content Editing
Many people think of editing as correcting spelling and grammar, but these tasks barely scrape the surface of what editing encompasses.
Over my next three posts, I will outline the main types of editing. Today, let me tell you about content editing.
Content editing—also referred to as structural editing—is the first stage of editing your work should undergo. This is when an editor works closest with an author to improve the overall content and structure of a piece of writing. An easy way to work out what happens at this stage is to consider the name; this level of editing focuses on the content and the structure of the writing.
Put simply, the aim is to strengthen arguments, develop the style and voice, and make sure the work flows logically. For creative pieces, this includes improving characterisation, writing dialogue, and checking for plotholes. For technical writing, it includes keeping the tone professional.
An editor provides constructive feedback to help guide the author in making changes. This process often includes rewriting and rearranging, adding to the manuscript, and removing unnecessary sections.
An editor will also be on the lookout for potential ethical and legal issues at this early stage. If any red flags pop up, an editor will help the author navigate the problem.
The focus on major changes during this stage is crucial. Correcting spelling, grammar, and punctuation is secondary until content/structural editing is over; they will be covered in the next stage.
bonneecrawfordediting	Editing	Leave a comment Mar 5, 2019 Mar 3, 2019 1 Minute


As You Sow is a nonprofit organization dedicated to increasing environmental and social corporate responsibility. Founded in 1992, As You Sow envisions a safe, just, and sustainable world in which environmental health and human rights are central to corporate decision making. Its Energy, Environmental Health, Waste, and Human Rights programs create positive, industry-wide change through corporate dialogue, shareholder advocacy, coalition building, and innovative legal strategies.
The Sustainable Investments Institute (Si2), a nonprofit research organization based in Washington, D.C., conducts impartial research and publishes reports on organized efforts to influence corporate behavior on social and environmental issues. Si2 closely follows shareholder resolutions proposed by investor advocates, but does not making voting recommendations. Instead, it provides the tools and in-depth reports that enable investors to make their own informed, independent decisions on the contentious public policy issues raised during proxy season. Si2 also conducts research into emerging sustainability issues to better help investors and the general public understand the implications they hold for companies and their key stakeholders. Recent reports covered political spending, hydraulic fracturing, integrated reporting, nanotechnologies and sustainable governance issues. Si2 is supported by leading institutional investors, including public and private pension funds, college and university endowments, foundations and fund managers.
Proxy Impact is a progressive proxy voting and shareholder engagement service for foundations, NGOs, and other mission-based or socially responsible investors. We provide affordable proxy voting that follows environment, social, and governance (ESG) guidelines; and vote confirmation that meets SEC and N-PX standards. Proxy Impact also offers a full range of shareholder engagement services on social and environmental issues including filing resolutions and corporate dialogues. Our unique consulting service will identify the links and advocacy opportunities between a client's stockholdings and their organization's mission, programs and/or grantees. This allows clients to leverage their shares to support their values and core programs, and provides strategic options for how to address key issues through their investments or grant making.


If you would like to guest post on our blog, please email social@coinmarketcap.com with your idea and plan for the post. Please note that it has to be educational and of interest to the wider CoinMarketCap audience.
For press releases, please email us here to enquire for pricing.
This is the best way to reach us, as our team works tirelessly day and night to read every single request that is sent to us. We are dedicated to the cryptocurrency community, as we have been since 2013 – so you can rest assured that we are working as quickly as we can on your feedback.
For other frequently asked questions, do look at our FAQ page, which answers some of the most common questions we get from our community.


text:
C.B. Geetha is an Indian politician, who was the municipal councillor of  Thrissur, Kerala and also chaired as Town Planning Standing Committee Chairman for Thrissur Municipal Corporation, representing the Olarikara ward.

She is the daughter of veteran Congress leader and ex-minister C. N. Balakrishnan and a working member of  Indian National Congress, serving as  the General Secretary to the Thrissur District Congress Committee. She also holds various profiles, including Chairperson of State Cooperative Insurance Society, Kerala,  President of Thrissur District Mahila Cooperative Society and Kerala Khadi Village Industries Association, Avinissery, Thrissur.

References

External links
Official Facebook Page of C B Geetha

Indian National Congress politicians from Kerala
Women in Kerala politics
Malayali politicians
Living people
1965 births
People from Thrissur district
21st-century Indian women politicians
21st-century Indian politicians

redpajama_set_name: RedPajamaWikipedia


Understand what the California Content Standards are, and how to access them.
Learn about the Common Core Standards for English Language Arts, and Mathematics.
Understand the importance of integrating the standards into academic and enrichment activities.
Learn strategies for planning activities in a balanced program that reinforces the standards in fun and engaging ways.


Premium Brown Leather Apron made of top grain leather material featuring one pocket in a brown lava color. The arc safety welding leather apron sewn with Kevlar threads for added longevity and strength. Rough and tough for all jobs, yet comfortable for prolonged daily use in the factory shop. Size 24x42 cut fits most users. The heat and cut resistant apron is durable with double reinforced sewn areas.


The Tritons were formed on April 16, 1941 and later organized a varsity swimming club on April 26, 1941, which, over time, became today's current synchronized swimming team at Wheaton. During the early stages of the club, Miss Brady and Miss Mott were picked as supervisors, while the swimmers worked on their formations. The Triton pin, which has become the national emblem of synchronized swimming, was also devised at that time. There were 17 charter members of the Tritons as early as October 18, 1941, and the group performed at the Boston YMCA. In October of 1955, Wheaton proposed a conference of Eastern colleges to set up the Association of Synchronized Swimming for college women. The next month, Notre Dame, Barnard, Penn, Mount Holyoke, Smith, Wellesley, UMass, Brooklyn, Jackson, Bouve, Cortland State, Syracuse and Buffalo came to Norton. At the next annual conference, the Triton was chosen as the emblem, honoring Wheaton as the founder of the association. In 1959, 75 colleges attended the conference and the membership was nationwide. The Tritons attended when the conference was in the East. The Tritons also appeared at many Play Days and at special symposia and gave demonstrations at Veterans Hospitals and carnivals, as well as may Wheaton events.


text:
Label: VALACYCLOVIR HYDROCHLORIDE tablet
These highlights do not include all the information needed to use VALACYCLOVIR TABLETS, USP safely and effectively. See full prescribing information for VALACYCLOVIR TABLETS, USP.
Warnings and Precautions, Central Nervous System Effects (5.3) 3/2010
Valacyclovir tablets is a deoxynucleoside analogue DNA polymerase inhibitor indicated for:
o Treatment in immunocompetent patients (initial or recurrent episode)
o Suppression in immunocompetent or HIV-1-infected patients
o reduction of transmission
Adult Dosage
Pediatric Dosage
Cold Sores (aged greater than
or equal to 12 years)
Chickenpox (aged 2 to less
than 18 years)
20 mg/kg 3 times daily for 5 days;
not to exceed 1 gram 3 times daily
Hypersensitivity to valacyclovir (e.g., anaphylaxis), acyclovir, or any component of the formulation. (4)
Central nervous system adverse reactions (e.g., agitation, hallucinations, confusion, and encephalopathy): May occur in both adult and pediatric patients (with or without reduced renal function) and in patients with underlying renal disease who receive higher-than-recommended doses of Valacyclovir hydrochloride for their level of renal function. Elderly patients are more likely to have central nervous system adverse reactions. Use with caution in elderly patients and reduce dosage in patients with renal impairment. (2.4, 515.3)
The most common adverse reactions reported in at least one indication by greater than10% of adult subjects treated with Valacyclovir hydrochloride and more commonly than in subjects treated with placebo are headache, nausea, and abdominal pain. (6.1)
The only adverse reaction occurring in greater than10% of pediatric subjects aged less than18 years was headache. (6.2)
To report SUSPECTED ADVERSE REACTIONS, contact Cipla Limited at 1-866-604-3268 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Herpes Zoster: Valacyclovir tablets are indicated for the treatment of herpes zoster (shingles) in immunocompetent adults. The efficacy of valacyclovir tablets when initiated more than 72 hours after the onset of rash and the efficacy and safety of valacyclovir tablets for treatment of disseminated herpes zoster have not been established.
Valacyclovir tablets are indicated for the treatment of cold sores (herpes labialis) in pediatric patients aged greater than or equal to 12 years. The efficacy of valacyclovir tablets, USP initiated after the development of clinical signs of a cold sore (e.g., papule, vesicle, or ulcer) has not been established.
Valacyclovir tablets are indicated for the treatment of chickenpox in immunocompetent pediatric patients aged 2 to less than18 years. Based on efficacy data from clinical trials with oral acyclovir, treatment with valacyclovir tablets should be initiated within 24 hours after the onset of rash [see Clinical Studies (14.4)].
Patients aged less than12 years with cold sores (herpes labialis).
Patients aged less than18 years with herpes zoster.
Valacyclovir oral suspension (25 mg/mL or 50 mg/mL) may be prepared extemporaneously from 500 mg Valacyclovir tablets for use in pediatric patients for whom a solid dosage form is not appropriate [see Dosage and Administration (2.3)] .
The recommended dosage of valacyclovir hydrochloride for treatment of cold sores is 2 grams twice daily for 1 day taken 12 hours apart. Therapy should be initiated at the earliest symptom of a cold sore (e.g., tingling, itching, or burning).
Initial Episode: The recommended dosage of valacyclovir hydrochloride for treatment of initial genital herpes is 1 gram twice daily for 10 days. Therapy was most effective when administered within 48 hours of the onset of signs and symptoms.
Recurrent Episodes: The recommended dosage of valacyclovir hydrochloride for treatment of recurrent genital herpes is 500 mg twice daily for 3 days. Initiate treatment at the first sign or symptom of an episode.
Suppressive Therapy: The recommended dosage of valacyclovir hydrochloride for chronic suppressive therapy of recurrent genital herpes is 1 gram once daily in patients with normal immune function. In patients with a history of 9 or fewer recurrences per year, an alternative dose is 500 mg once daily.
In HIV-1-infected patients with a CD4+ cell count greater than or equal to 100 cells/mm3, the recommended dosage of valacyclovir hydrochloride for chronic suppressive therapy of recurrent genital herpes is 500 mg twice daily.
Reduction of Transmission: The recommended dosage of valacyclovir hydrochloride for reduction of transmission of genital herpes in patients with a history of 9 or fewer recurrences per year is 500 mg once daily for the source partner.
The recommended dosage of valacyclovir hydrochloride for treatment of herpes zoster is 1 gram 3 times daily for 7 days. Therapy should be initiated at the earliest sign or symptom of herpes zoster and is most effective when started within 48 hours of the onset of rash.
The recommended dosage of valacyclovir hydrochloride for the treatment of cold sores in pediatric patients aged greater than or equal to 12 years is 2 grams twice daily for 1 day taken 12 hours apart. Therapy should be initiated at the earliest symptom of a cold sore (e.g., tingling, itching, or burning).
The recommended dosage of valacyclovir hydrochloride for treatment of chickenpox in immunocompetent pediatric patients aged 2 to less than 18 years is 20 mg/kg administered 3 times daily for 5 days. The total dose should not exceed 1 gram 3 times daily. Therapy should be initiated at the earliest sign or symptom [see Use in Specific Populations (8.4), Clinical Pharmacology (12.3), Clinical Studies (14.4)].
Using a pestle and mortar, grind the required number of Valacyclovir tablets 500- mg until a fine powder is produced (5 Valacyclovir tablets for 25-mg/mL suspension; 10 Valacyclovir tablets for 50-mg/mL suspension).
Gradually add approximately 5-mL aliquots of SSV to the mortar and triturate the powder until a paste has been produced. Ensure that the powder has been adequately wetted.
Continue to add approximately 5-mL aliquots of SSV to the mortar, mixing thoroughly between additions, until a concentrated suspension is produced, to a minimum total quantity of 20-mL SSV and a maximum total quantity of 40-mL SSV for both the 25- mg/mL and 50-mg/mL suspensions.
Transfer the mixture to a suitable 100-mL measuring flask.
Rinse the mortar at least 3 times with approximately 5-mL aliquots of SSV, transferring the rinsing to the measuring flask between additions.
The prepared suspension should be labeled with the following information "Shake well before using. Store suspension between 2° to 8°C (36° to 46°F) in a refrigerator. Discard after 28 days."
Dosage recommendations for adult patients with reduced renal function are provided in Table 1
[see Use in Specific Populations (8.5, 8.6), Clinical Pharmacology (12.3)]. Data are not available for the use of Valacyclovir hydrochloride tablets in pediatric patients with a creatinine clearance less than 50 mL/min/1.73 m2.
Table 1. Valacyclovir hydrochloride Dosage Recommendations for Adults With Renal Impairment
Creatinine Clearance
(mL/min)
(Creatinine
Do not exceed 1 day of
500 mg single dose
Immunocompetent
Alternate dose for
patients with less than or equal to 9
recurrences/year
500 mg every 48 hours
Patients requiring hemodialysis should receive the recommended dose of valacyclovir hydrochloride after hemodialysis. During hemodialysis, the half-life of acyclovir after administration of valacyclovir hydrochloride is approximately 4 hours. About one-third of acyclovir in the body is removed by dialysis during a 4-hour hemodialysis session.
There is no information specific to administration of valacyclovir hydrochloride in patients receiving peritoneal dialysis. The effect of chronic ambulatory peritoneal dialysis (CAPD) and continuous arteriovenous hemofiltration/dialysis (CAVHD) on acyclovir pharmacokinetics has been studied. The removal of acyclovir after CAPD and CAVHD is less pronounced than with hemodialysis, and the pharmacokinetic parameters closely resemble those observed in patients with end-stage renal disease (ESRD) not receiving hemodialysis. Therefore, supplemental doses of valacyclovir hydrochloride should not be required following CAPD or CAVHD.
500 mg: blue coloured, film-coated, capsule-shaped, biconvex tablets, "CIPLA" debossed on one side and "153" on other.
1 gram: blue coloured, film-coated, capsule-shaped, biconvex tablets, with a partial scorebar on both sides, and "CIPLA" debossed on one side and "154" on other.
Valacyclovir hydrochloride is contraindicated in patients who have had a demonstrated clinically significant hypersensitivity reaction (e.g., anaphylaxis) to valacyclovir, acyclovir, or any component of the formulation [see Adverse Reactions (6.3)].
Acute Renal Failure [see Warnings and Precautions (5.2)] .
Central Nervous System Effects [see Warnings and Precautions (5.3)] .
The most common adverse reactions reported in at least 1 indication by greater than 10% of adult subjects treated with valacyclovir hydrochloride and observed more frequently with valacyclovir hydrochloride compared with placebo are headache, nausea, and abdominal pain. The only adverse reaction reported in greater than 10% of pediatric subjects aged less than18 years was headache.
Initial Episode: In a clinical trials for the treatment of initial episodes of genital herpes, the adverse reactions reported by greater than or equal to 5% of subjects receiving valacyclovir hydrochloride 1 gram twice daily for 10 days (n = 318) or oral acyclovir 200 mg 5 times daily for 10 days (n = 318), respectively, included headache (13%, 10%) and nausea (6%, 6%). For the incidence of laboratory abnormalities see Table 2.
Recurrent Episodes: In 3 clinical trials for the episodic treatment of recurrent genital herpes, the adverse reactions reported by greater than or equal to 5% of subjects receiving valacyclovir hydrochloride 500 mg twice daily for 3 days (n = 402), valacyclovir hydrochloride 500 mg twice daily for 5 days (n = 1,136) or placebo (n = 259), respectively, included headache (16%, 11%, 14%) and nausea (5%, 4%, 5%).
For the incidence of laboratory abnormalities see Table 2.
Suppressive Therapy: Suppression of Recurrent Genital Herpes in Immunocompetent Adults: In a clinical trials for the suppression of recurrent genital herpes infections, the adverse reactions reported by subjects receiving valacyclovir hydrochloride 1 gram once daily (n = 269), valacyclovir hydrochloride 500 mg once daily (n = 266), or placebo (n = 134), respectively, included headache (35%, 38%, 34%), nausea (11%, 11%, 8%), abdominal pain (11%, 9%, 6%), dysmenorrhea (8%, 5%, 4%), depression (7%, 5%, 5%), arthralgia (6%, 5%, 4%), vomiting (3%, 3%, 2%), and dizziness (4%, 2%, 1%). For the incidence of laboratory abnormalities see Table 2.
Reduction of Transmission: In a clinical trials for the reduction of transmission of genital herpes, the adverse reactions reported by subjects receiving valacyclovir hydrochloride 500 mg once daily (n = 743) or placebo once daily (n = 741), respectively, included headache (29%, 26%), nasopharyngitis (16%, 15%), and upper respiratory tract infection (9%, 10%).
ULN = Upper limit of normal
Herpes Zoster Genital Herpes Treatment Genital Herpes Suppression
Abnormality Valacyclovir\Hydrochlorie
(n = 967) Placebo
(n =195) Valacyclovir
Hydrochlorid
(n = 1,194) Valacyclovir
500 mg Twice
(n = 1,159) Placebo
(n = 439) Valacyclovir
1 gram Once
500 mg Once
(<0.8 x LLN) 0.8% 0% 0.3% 0.2% 0% 0% 0.8% 0.8%
White blood cells (<0.75 x LLN) 1.3% 0.6% 0.7% 0.6% 0.2% 0.7% 0.8% 1.5%
Platelet count (<100,000/mm3) 1.0% 1.2% 0.3% 0.1% 0.7% 0.4% 1.1% 1.5%
(>2 x ULN) 1.0% 0% 1.0% a 0.5% 4.1% 3.8% 3.0%
Serum creatinine (>1.5 x ULN) 0.2% 0% 0.7% 0% 0% 0% 0% 0%
The safety profile of valacyclovir hydrochloride has been studied in 177 pediatric subjects aged 1 month to less than 18 years. Sixty-five of these pediatric subjects, aged 12 to less than 18 years, received oral tablets for 1 to 2 days for treatment of cold sores. The remaining 112 pediatric subjects, aged 1 month to less than 12 years, participated in 3 pharmacokinetic and safety studies and received valacyclovir oral suspension. Fifty-one of these 112 pediatric subjects received oral suspension for 3 to 6 days. The frequency, intensity, and nature of clinical adverse reactions and laboratory abnormalities were similar to those seen in adults.
Adverse events reported in more than 1 subject across the 3 pharmacokinetic and safety trials in children aged 1 month to less than 12 years were diarrhea (5%), pyrexia (4%),dehydration (2%), herpes simplex (2%), and rhinorrhea (2%). No clinically meaningful changes in laboratory values were observed.
The Acyclovir and the Valacyclovir Pregnancy Registries, both population-based international prospective studies, collected pregnancy data through April 1999. The Acyclovir Registry documented outcomes of 1,246 infants and fetuses exposed to acyclovir during pregnancy (756 with earliest exposure during the first trimester, 197 during the second trimester, 291 during the third trimester, and 2 unknown). The occurrence of major birth defects during first-trimester exposure to acyclovir was 3.2% (95% CI: 2.0% to 5.0%) and during any trimester of exposure was 2.6% (95% CI: 1.8% to 3.8%). The Valacyclovir Pregnancy Registry documented outcomes of 111 infants and fetuses exposed to valacyclovir during pregnancy (28 with earliest exposure in the first trimester, 31 during the second trimester, and 52 during the third trimester).The occurrence of major birth defects during first-trimester exposure to valacyclovir was 4.5% (95% CI: 0.24% to 24.9%) and during any trimester of exposure was 3.9% (95% CI:1.3% to 10.7%).
Available studies have methodological limitations including insufficient sample size to support conclusions about overall malformation risk or for making comparisons of the frequencies ofspecific birth defects.
Although there is no information on the presence of valacyclovir in human milk, its metabolite, acyclovir, is present in human milk following oral administration of valacyclovir. Based on published data, a 500-mg maternal dose of valacyclovir twice daily would provide a breastfed child with an oral acyclovir dosage of approximately 0.6 mg/kg/day (see Data). There is no data on the effects of valacyclovir or acyclovir on the breastfed child or on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother's clincal need for valacyclovir and any potential adverse effects on the breastfed child from valacyclovir or from the underlying maternal condition.
Following oral administration of a 500-mg dose of valacyclovir to 5 lactating women, peak acyclovir concentrations (Cmax) in breast milk ranged from 0.5 to 2.3 times (median 1.4) the corresponding maternal acyclovir serum concentrations. The acyclovir breast milk AUC ranged from 1.4 to 2.6 times (median 2.2) maternal serum AUC. A 500-mg maternal dose of valacyclovir twice daily would provide a breastfed child with an oral acyclovir dosage of approximately 0.6 mg/kg/day. Unchanged valacyclovir was not detected in maternal serum, breast milk or infant urine.
The use of valacyclovir hydrochloride for treatment of cold sores is based on 2 double-blind, placebo-controlled clinical trials in healthy adults and adolescents (aged greater than or equal to 12 years) with a history of recurrent cold sores [see Clinical Studies (14.1)].
The use of valacyclovir hydrochloride for treatment of chickenpox in pediatric patients aged 2 to less than 18 years is based on single-dose pharmacokinetic and multiple-dose safety data from an open-label trial with valacyclovir and supported by efficacy and safety data from 3 randomized, double-blind, placebo-controlled trials evaluating oral acyclovir in pediatric subjects with chickenpox [see Dosage and Administration (2.2), Adverse Reactions (6.2),Clinical Pharmacology (12.3), Clinical Studies (14.4)].
Trial 1 was a single-dose pharmacokinetic, multiple-dose safety trial in 27 pediatric subject aged 1 to less than 12 years with clinically suspected varicella-zoster virus (VZV) infection [see Dosage and Administration (2.2), Adverse Reactions (6.2), Clinical Pharmacology (12.3), Clinical Studies (14.4)].
Trial 2 was a single-dose pharmacokinetic and safety trial in pediatric subject aged 1 month to less than 6 years who had an active herpes virus infection or who were at risk for herpes virus infection. Fifty-seven subjects were enrolled and received a single dose of 25 mg/kg valacyclovir oral suspension. In infants and children aged 3 months to less than 6 years, this dose provided comparable systemic acyclovir exposures to that from a 1-gram dose of valacyclovir in adults (historical data). In infants aged 1 month to less than 3 months, mean acyclovir exposures resulting from a 25-mg/kg dose were higher (Cmax: ↑30%, AUC: ↑60%) than acyclovir exposures following a 1-gram dose of valacyclovir in adults. Acyclovir is not approved for suppressive therapy in infants and children following neonatal HSV infections; therefore valacyclovir is not recommended for this indication because efficacy cannot be extrapolated from acyclovir.
Trial 3 was a single-dose pharmacokinetic, multiple-dose safety trial in 28 pediatric subjects aged 1 to less than 12 years with clinically suspected HSV infection. None of the subjects enrolled in this trial had genital herpes. Each subject was dosed with valacyclovir oral suspension, 10 mg/kg twice daily for 3 to 5 days. Acyclovir systemic exposures in pediatric subjects following valacyclovir oral suspension were compared with historical acyclovir systemic exposures in immunocompetent adults receiving the solid oral dosage form of valacyclovir or acyclovir for the treatment of recurrent genital herpes. The mean projected daily acyclovir systemic exposures in pediatric subjects across all age-groups (1 to less than 12 years) were lower (Cmax: ↓20%, AUC: ↓33%) compared with the acyclovir systemic exposures in adults receiving valacyclovir 500 mg twice daily but were higher (daily AUC: ↑16%) than systemic exposures in adults receiving acyclovir 200 mg 5 times daily. Insufficient data are available to support valacyclovir for the treatment of recurrent genital herpes in this age-group because clinical information on recurrent genital herpes in young children is limited; therefore, extrapolating efficacy data from adults to this population is not possible. Moreover, valacyclovir has not been studied in children aged 1 to less than 12 years with recurrent genital herpes.
Of the total number of subjects in clinical trials of valacyclovir hydrochloride, 906 were 65 and over, and 352 were 75 and over. In a clinical trial of herpes zoster, the duration of pain after healing (post-herpetic neuralgia) was longer in subject 65 and older compared with younger adults. Elderly patients are more likely to have reduced renal function and require dose reduction. Elderly patients are also more likely to have renal or CNS adverse events [see Dosage and Administration (2.4), Warnings and Precautions (5.2, 5.3), Clinical Pharmacology (12.3)].
Valacyclovir hydrochloride USP is the hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir.
Valacyclovir tablets, USP are for oral administration. Each tablet contains valacyclovir hydrochloride USP equivalent to 500 mg or 1 gram valacyclovir and the inactive ingredients croscarmellose sodium, FD&C Blue #2, hydrogenated castor oil, hypromellose, polyethylene glycol, polysorbate 80, starch (corn), and titanium dioxide.
Valacyclovir hydrochloride USP is a white to off-white powder with the molecular formula C13H20N6O4•HCl and a molecular weight of 360.80. The maximum solubility in water at 25°C is 174 mg/mL. The pkas for valacyclovir hydrochloride are 1.90, 7.47, and 9.43.
The absolute bioavailability of acyclovir after administration of valacyclovir hydrochloride is 54.5% ± 9.1% as determined following a 1-gram oral dose of valacyclovir hydrochloride and a 350 mg intravenous acyclovir dose to 12 healthy volunteers. Acyclovir bioavailability from the administration of valacyclovir hydrochloride is not altered by administration with food (30 minutes after an 873 Kcal breakfast, which included 51 grams of fat).
ND = not done
Dose Single-Dose Administration
(N = 8) Multiple-Dose Administration a
Cmax (±SD) (mcg/mL) AUC (±SD) (h●mcg/mL) Cmax (±SD) (mcg/mL) AUC (±SD) (h●mcg/mL)
100 mg 0.83 (±0.14) 2.28 (±0.40) ND ND
250 mg 2.15 (±0.50) 5.76 (±0.60) 2.11 (±0.33) 5.66 (±1.09)
500 mg 3.28 (±0.83) 11.59 (±1.79) 3.69 (±0.87) 9.88 (±2.01)
750 mg 4.17 (±1.14) 14.11 (±3.54) ND ND
1,000 mg 5.65 (±2.37) 19.52 (±6.04) 4.96 (±0.64) 15.70 (±2.27)
Elimination: The pharmacokinetic disposition of acyclovir delivered by valacyclovir is consistent with previous experience from intravenous and oral acyclovir. Following the oral administration of a single 1-gram dose of radiolabeled valacyclovir to 4 healthy subjects, 46% and 47% of administered radioactivity was recovered in urine and feces, respectively, over 96 hours. Acyclovir accounted for 89% of the radioactivity excreted in the urine. Renal clearance of acyclovir following the administration of a single 1-gram dose of valacyclovir hydrochloride to 12 healthy subjects was approximately 255 ± 86 mL/min which represents 42% of total acyclovir apparent plasma clearance.
Patient with Renal Impairment: Reduction in dosage is recommended in patients with renal impairment [see Dosage and Administration (2.4), Use in Specific Populations (8.5), (8.6)].
Following administration of valacyclovir hydrochloride to subjects with ESRD, the average acyclovir half-life is approximately 14 hours. During hemodialysis, the acyclovir half-life is approximately 4 hours. Approximately one third of acyclovir in the body is removed by dialysis during a 4-hour hemodialysis session. Apparent plasma clearance of acyclovir in subjects on dialysis was 86.3 ± 21.3 mL/min/1.73 m2compared with 679.16 ± 162.76 mL/min/1.73 m2in healthy subjects
Patient with Hepatic Impairment: Administration of valacyclovir hydrochloride to subjects with moderate (biopsy-proven cirrhosis) or severe (with and without ascites and biopsy-proven cirrhosis) liver disease indicated that the rate but not the extent of conversion of valacyclovir to acyclovir is reduced, and the acyclovir half-life is not affected. Dosage modification is not recommended for patients with cirrhosis.
Patient with HIV-1 Disease: In 9 subjects with HIV-1 disease and CD4+ cell counts less than 150 cells/mm3who received valacyclovir hydrochloride at a dosage of 1 gram 4 times daily for 30 days, the pharmacokinetics of valacyclovir and acyclovir were not different from that observed in healthy subjects.
Geriatrics Patients: After single-dose administration of 1 gram of valacyclovir hydrochloride in healthy geriatric subjects, the half-life of acyclovir was 3.11 ± 0.51 hours, compared with 2.91 ± 0.63 hours in healthy younger adult subjects. The pharmacokinetics of acyclovir following single- and multiple-dose oral administration of valacyclovir hydrochloride in geriatric subjects varied with renal function. Dose reduction may be required in geriatric patients, depending on the underlying renal status of the patient [see Dosage and Administration (2.4), Use in Specific Populations (8.5, 8.6)].
Pediatrics Patients: Acyclovir pharmacokinetics have been evaluated in a total of 98 pediatric subjects (aged 1 month to less than 12 years) following administration of the first dose of an extemporaneous oral suspension of valacyclovir [see Adverse Reactions (6.2), Use in Specific Populations (8.4)]. Acyclovir pharmacokinetic parameter estimates following a 20 mg/kg dose are provided in Table 4.
1-gram Solid Dose
of Valacyclovir
hydrochloride a
1 - <2 year
6 - <12 year
AUC (mcg•h/mL) Cmax (mcg/mL)
Drug Interactions Studies
Antacids: The pharmacokinetics of acyclovir after a single dose of valacyclovir hydrochloride (1 gram) were unchanged by coadministration of a single dose of antacids (Al3+or Mg++).
Valacyclovir is a deoxynucleoside analogue DNA polymerase inhibitor. Valacyclovir hydrochloride is rapidly converted to acyclovir which has demonstrated antiviral activity against HSV types 1 (HSV-1) and 2 (HSV-2) and VZV both in cell culture and in vivo.
Cross-resistance has been observed among HSV isolates carrying frameshift mutations and resistance-associated substitutions, which confer reduced susceptibility to penciclovir, famciclovir (FCV), and foscarnet (FOS) (Table 7).
The mean duration of cold sore episodes was about 1 day shorter in treated subjects as compared with placebo. The 2 day regimen did not offer additional benefit over the 1-day regimen.
Six hundred forty-three immunocompetent adults with first-episode genital herpes who presented within 72 hours of symptom onset were randomized in a double-blind trial to receive 10 days of valacyclovir hydrochloride 1 gram twice daily (n = 323) or oral acyclovir 200 mg 5 times a day (n = 320). For both treatment groups: the median time to lesion healing was 9 days, the median time to cessation of pain was 5 days, and the median time to cessation of viral shedding was 3 days.
In 1 trial, subjects were randomized to receive 5 days of treatment with either valacyclovir hydrochloride 500 mg twice daily (n = 360) or placebo (n = 259). The median time to lesion healing was 4 days in the group receiving valacyclovir hydrochloride 500 mg versus 6 days in the placebo group, and the median time to cessation of viral shedding in subjects with at least 1 positive culture (42% of the overall trial population) was 2 days in the group receiving valacyclovir hydrochloride 500 mg versus 4 days in the placebo group. The median time to cessation of pain was 3 days in the group receiving valacyclovir hydrochloride 500 mg versus 4 days in the placebo group. Results supporting efficacy were replicated in a second trial.
hydrochloride
Unknown a
Valacyclovir hydrochloride a
Two randomized double-blind clinical trials in immunocompetent adults with localized herpes zoster were conducted. Valacyclovir hydrochloride was compared with placebo in subjects aged less than 50 years, and with oral acyclovir in subjects aged greater than 50 years. All subjects were treated within 72 hours of appearance of zoster rash. In subjects aged less than 50 years, the median time to cessation of new lesion formation was 2 days for those treated with valacyclovir hydrochloride compared with 3 days for those treated with placebo. In subjects aged greater than 50 years, the median time to cessation of new lesions was 3 days in subjects treated with either valacyclovir hydrochloride or oral acyclovir. In subjects aged less than 50 years, no difference was found with respect to the duration of pain after healing (post-herpetic neuralgia) between the recipients of valacyclovir hydrochloride and placebo. In subjects aged greater than 50 years, among the 83% who reported pain after healing (post-herpetic neuralgia), the median duration of pain after healing (95% confidence interval) in days was: 40 (31, 51), 43 (36, 55), and 59 (41, 77) for 7-day valacyclovir hydrochloride, 14-day valacyclovir hydrochloride, and 7-day oral acyclovir, respectively.
The single-dose pharmacokinetic and multiple-dose safety trial enrolled 27 pediatric subjects aged 1 to less than 12 years of with clinically suspected VZV infection. Each subject was dosed with valacyclovir oral suspension, 20 mg/kg 3 times daily for 5 days. Acyclovir systemic exposures in pediatric subjects following valacyclovir oral suspension were compared with historical acyclovir systemic exposures in immunocompetent adults receiving the solid oral dosage form of valacyclovir or acyclovir for the treatment of herpes zoster. The mean projected daily acyclovir exposures in pediatric subjects across all age-groups (1 to less than 12 years) were lower (Cmax: ↓13%, AUC: ↓30%) than the mean daily historical exposures in adults receiving valacyclovir 1 gram 3 times daily, but were higher (daily AUC: ↑50%) than the mean daily historical exposures in adults receiving acyclovir 800 mg 5 times daily. The projected daily exposures in pediatric subjects were greater (daily AUC approximately 100% greater) than the exposures seen in immunocompetent pediatric subjects receiving acyclovir 20 mg/kg 4 times daily for the treatment of chickenpox. Based on the pharmacokinetic and safety data from this trial and the safety and extrapolated efficacy data from the acyclovir trials, oral valacyclovir 20 mg/kg 3 times a day for 5 days (not to exceed 1 gram 3 times daily) is recommended for the treatment of chickenpox in pediatric patients aged 2 to less than 18 years. Because the efficacy and safety of acyclovir for the treatment of chickenpox in children aged less than 2 years have not been established, efficacy data cannot be extrapolated to support valacyclovir treatment in children aged less than 2 years with chickenpox. Valacyclovir is also not recommended for the treatment of herpes zoster in children because safety data up to 7 days' duration are not available [see Use in Specific Populations (8.4)].
Instruct patients that if they miss a dose of valacyclovir tablets, to take it as soon as they remember. Advise patients not to double their next dose or take more than the prescribed dose.
There are no data on the safety or effectiveness of chronic suppressive therapy of more than 1 year's duration in otherwise healthy patients. There are no data on the safety or effectiveness of chronic suppressive therapy of more than 6 months' duration in HIV-infected patients.
Cipla Limited
Verna Goa, INDIA
Cipla USA, Inc.
10 Independence Boulevard,
Suite 300, Warren, NJ 07059
PHARMACIST-DETACH HERE AND GIVE INSTRUCTIONS TO PATIENT
PATIENT PACKAGE INSERT
VALACYCLOVIR (val'' ay sye' kloe vir) TABLETS
What is valacyclovir tablets?
Valacyclovir tablets is a prescription medicine used in adults
to treat cold sores (herpes labialis)
to treat or control genital herpes outbreaks in adults with normal immune systems
to treat or control genital herpes outbreaks in adults with human immunodeficiency virus-1 (HIV-1).
with safer sex practices to lower the chances of spreading genital herpes to others, in adults with normal immune systems. Even with safer sex practices, it is still possible to spread genital herpes.
Valacyclovir tablets is used in children to treat:
cold sores in children 12 years of age and older
Valacyclovir tablets does not cure cold sores, chickenpox, shingles, or genital herpes.
It is not known if valacyclovir tablets are safe and effective in people with weakened immune systems, other than for control of outbreaks of genital herpes in people with HIV-1.
are breastfeeding or plan to breastfeed. Valacyclovir tablets may pass into your breastmilk. Talk with your healthcare provider about the best way to feed your child if you take valacyclovir tablets.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements
Do not take too much valacyclovir tablets, call your healthcare provider or go to the nearest hospital emergency room right away.
Store valacyclovir tablets at room temperature, 68°F to 77°F (20° to 25°C).
Store valacyclovir tablets suspension between 2°C to 8°C (36° to 46°F) in a refrigerator. Discard after 28 days.
Shake Valacyclovir oral suspension bottle well before using.
Do not keep medicine that is out of date or that you no longer need.
General information about the safe and effective use of valacyclovir tablets
Medicines are sometimes prescribed for purposes other than those listed in Patient Information leaflets. Do not use valacyclovir tablets for a condition for which it was not prescribed. Do not give valacyclovir tablets to other people, even if they have the same symptoms that you have. It may harm them. You can ask your healthcare provider or pharmacist for information about valacyclovir tablets that is written for health professionals.
What are the ingredients in valacyclovir tablets, USP?
Inactive Ingredients croscarmellose sodium, FD&C Blue #2, hydrogenated castor oil, hypromellose, polyethylene glycol, polysorbate 80, starch (corn), and titanium dioxide.
valacyclovir hydrochloride tablet
CROSCARMELLOSE SODIUM (UNII: M28OL1HH48)
HYDROGENATED CASTOR OIL (UNII: ZF94AP8MEY)
HYPROMELLOSE 2910 (3 MPA.S) (UNII: 0VUT3PMY82)
STARCH, CORN (UNII: O8232NY3SJ)
Flavor Imprint Code CIPLA153
https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=0548a983-bb83-4713-9326-469dc483f7b1


Darkness Is Not Just Turning Down The Light! Find complete synergy with this ambitious dark bronzing tanning formula that will make everyone envious of your gorgeous, Incredibly Black allure. Go super dark with this 10X bronzing blend harmoniously infused with advanced tanning accelerators, natural exotic extracts, Monoi de Tahiti Oil and the perfect skin conditioning properties of pure Aloe Vera. It's All About Me!


and a lively bubble. . .
the freeway brushing sound. . .
the soaring sweep. . .
This entry was posted in Medium Length Poems, Poetry, Seasons, Summer and tagged Airplane, August, Complaints, Fog, Freeway, Glass half empty, Gray Sky, Love, Summer, Thought. Bookmark the permalink.


text:
Aberdeen 3 Dundee United 1 – Pittodrie Stadium 15/10/11
Aberdeen City, Articles, Community, Featured, Information, Opinion, Sport No Responses »
Back to back wins, a five-figure home attendance creating a good atmosphere, and a team physically dominating a match to a comfortable victory…surely this can't be the Aberdeen FC of this season we're talking about?! Philip Sim reports from Pittodrie.
Last time out against Dunfermline, Aberdeen created innumerable chances and only visiting stopper Paul Gallacher prevented the match ending with a cricket score.
Dundee United were expected to provide a much stiffer challenge than the SPL new boys, but in truth the Dons did not even have to play as well as they did against the Fifers to record a comfortable victory.
Dusan Pernis is normally a solid, reliable goalkeeper, but he made a bad error in United's last match against Motherwell, and he seems low on confidence.
He did very well to parry Rory Fallon's header seconds before Kari Arnason stabbed home the opener, but his kicking was all over the place and even Andrew Considine will be wondering how his trundling effort crept in for Aberdeen's third.
The visitor's deficiencies didn't start or end at the back however.
United lost an entire midfield of talented players over the summer, and have tried to replace them with kids and the extremely average John Rankin. By contrast Aberdeen's summer signings Kari Arnason and Isaac Osbourne had little trouble in taking the game by the scruff of the neck and absolutely controlling proceedings in the middle of the park.
Osbourne in particular didn't miss a tackle, and his graft and tidy use of the ball left Aberdeen dominating the midfield, despite Fraser Fyvie and Rob Milsom having relatively quiet games.
At the back, the Dons were if anything even more impenetrable. United captain Jon Daly must think of Pittodrie as a fairly happy hunting ground, but he barely got a touch of the ball in this match with Youll Mawene and Andy Considine winning everything in the air and on the deck. Each also popped up with a goal at set pieces – another mark of how the Dons totally won the physical battle against opponents who are no lightweights themselves.
Up front, Fallon and Scott Vernon are beginning to understand each other better and better as a strike partnership, and the big Kiwi seems to be exactly the foil that Vernon needs to get back to the goalscoring form he showed last season.
Fallon is excellent in the air and at holding the ball up which leaves Vernon free to burst into goalscoring positions. The pair of them pose far more of a threat than the previously tried combinations which used Vernon or Magennis as the target man – as was proved after Fallon's substitution when the Dons lost much of their bite going forward.
Much like Spain against Scotland in midweek – although admittedly with only an ounce of the panache – Aberdeen bossed their opponents with ease for the first hour, but after going 3 – 0 up were guilty of taking their foot off the gas and allowing the visitors back into the game.
United's goal was no more than a consolation for the visiting support, but it took some of the gloss off an impressive Aberdeen display.
Brown's substitutions in particular seemed to take a lot out of the Dons – Chris Clark once again failed to impress, the game seeming to pass him by, and as mentioned earlier the team really seemed to miss the presence of Fallon up front after he was replaced by Magennis.
Willie Collum took charge of the match and did little to endear himself to either set of supporters, strangling any hope of free-flowing football by awarding a succession of needless free-kicks for niggly half-fouls. He turned down a decent penalty claim for both sides in the first half, although his decision to wave away Danny Swanson's claims were probably quite strongly influenced by his earlier denial of Rob Milsom.
Two wins on the trot is as good a way to bounce back from an embarrassing cup defeat as any, and Craig Brown seems well on the way to having a settled starting eleven.
The next two games are going to be a massive test for his squad's new-found confidence though, with a trip to Parkhead followed by the visit of Rangers. The Old Firm sides were both held to draws this weekend and Celtic in particular look to be there for the taking – and for the first time this season, Aberdeen look capable of putting a run together.
The feel-good factor is back at Pittodrie.
Posted by Fred at Aberdeen Voice at 18:45 Tagged with: Aberdeen, AFC, Archie Knox, Army, Arnason, Back, Box, Captain, Celtic, Chalali, Chris Clark, Club, Columbian, Considine, Craig Brown, Cup, Darren Mackie, Defence, Division, Dons, Dundee, Dunfermline, Fife, Fir, Football, Forward, Full, Fyvie, Glasgow, Goalkeeper, Gonzales, Iceland, Isaac, Jason Brown, Keeper, League, Magennis, Mawene, McArdle, Megginson, Midfield, Milsom, Motherwell, Old, Osbourne, Park, Pars, Paul Gallacher, Pawlett, Penalties, Penalty, Philip Sim, Pittodrie, Post, Rangers, Red, Referee, Results, Richard Foster, Rory Fallon, Ryan Jack, Saves, Scottish, Season, Sentre, Signings, Six, Spain, SPL, Striker, Target, Time, United, Well, Willie Collum, Woodwork, Yoann Folly
Refs Blow Whistle On Abuse
Aberdeen City, Articles, Opinion, Sport No Responses »
Voice's David Innes, a sometime bastard in the black, looks at this week's threatened strike by SPL referees after weeks of controversy.
When Willie Collum sent Rory McArdle off at Pittodrie last week, I joined with the rest of the fair-minded, judicious and sagely punters of Section Y in ranting foul-mouthedly about the ref's dubious lineage, his resemblance to both male and female external reproductive organs and the fact that were he ever to join the Mile High Club, it would be a solo flight.
I was not the worst, but I held my own. Just as we were accusing him of doing, I suppose. That's where it ended though. No matter what resentment I felt at Collum's performance, it's over, it's in the past and I'm now more concerned about where we'll be in the table come the festive season.
I think that's the way most fans take these things. We rage when things go against us but suffer memory blanks for decisions which have gone in our favour. We rant, we rave, we slaver and gnash our teeth, but accept it stoically as part of the game. And we should not forget that it IS just a game.
I cannot understand what goes on in the minds of supporters who insist on taking these things further, to the extent of threatening referees, their homes and property and their families. What sort of empty lives must such individuals and mobs lead to make them behave in such a way? I'm as fanatical as the next fan about my team, I love to see them winning – and it will happen again, believe – and can take defeat badly especially against certain teams.
Of course, I have long held the opinion that those who wish to associate themselves with the alien and discriminatory cultures at certain successful clubs, having no local or cultural affinity with those clubs have something missing from their lives anyway, but that is another debate.
Referees are now threatening to strike because they feel their integrity has been called into question. Dougie McDonald has admitted lying and should resign. That would not be the end of the matter, I'm sure, despite what some influential people claim. Before long, some other poor sap in black would be accused of being part of the conspiracy against whoever feels slighted and who cannot accept that some days you're the doo and on others, you're the statue.
Being called a wanker by 10-year olds quickly loses its precocious charm
Do I support the strike? Yes, and not just because of the high profile issue currently exciting Jimmy Inarticulate, first-time caller by the way Jim, and readers of the Daily Paps.
In years gone by, as a fitba coach asked to referee games every week, I thought I'd better do the knowledge and make sure that every time I blew the Acme Thunderer that I knew what the hell I was deciding. I went over to the Dark Side, turned from poacher to gamie, took the king's shilling and became a bastard in the black. It was great fun. I learned a lot. I found out that playground-ingrained received wisdom was, well, not really wise at all.
I didn't last too long doing it as a favour to kids' teams though. Being called a wanker by 10-year olds quickly loses its precocious charm. Dealing with boorish coaches who believed they were Alex Ferguson and who seemed intent on acting out their own fitba fantasies by instructing bairns to kick and maim other bairns saddened me. Doing the right thing by talking to players, telling 'keepers, "Aye, it's OK to pick it up, it wisna a pass back" or taking 5 minutes at half time to instruct a constantly-infringing team on the correct way to take a throw-in but being abused by grown men on the sidelines for so doing wasn't an ideal way to spend a sleety Sunday morning at Aulton.
Watching 9 year olds dive outrageously to try to win penalties (not on MY watch, sonny) and adopt other "professional" insidiousness they had seen on Murdoch TV disillusioned me. It did the same to many of my peers who began with less cynicism than I had. We just became "unavailable" when asked. The message got through quickly enough and the calls stopped.
It begins at that level. It reaches its pathetic zenith at professional level. Someone's going to get hurt and by then it will be too late for recriminations and hand-wringing.
Have your strike, comrades. It's unlikely that I'll be at an SPL game this week, but I'd happily join in the "scab" chants at the shoehorned-in replacements who will be adding to the problem rather than help solve it.
Posted by at 05:00 Tagged with: David Innes, Football, Murdoch, SPL, Sport, Strike, Willie Collum


text:
Climate change law in Ghana: analysis of national legal frameworks for climate action and development
This legal analysis provides an assessment of Ghana's key legal and regulatory frameworks for the priorities highlighted in Ghana's Nationally Determined Contributions (NDCs) and Ghana's climate agenda more generally. The assessment includes an analysis of gaps or inconsistencies between the Government's stated climate plans and commitments and existing national policy and legislation, with a view to evaluating the ability of existing legal frameworks to support Ghana's delivery of its climate commitments and policy goals. The analysis focuses on four key sectors: water; agriculture, forestry, and other land use (AFOLU); energy; and transport. In addition, the legal analysis research team identified broader elements of the legal enabling environment in Ghana that are essential to the effective implementation of Ghana's NDC and the achievement of Ghana's climate policy goals; these elements include the country's constitution, law-making and rulemaking processes, administrative and judicial enforcement mechanisms, environmental and social impact assessment laws and regulations, and the legal frameworks to mobilize public and private finance. The analysis proposes general and sector-specific recommendations to better align existing national policy and legislation with the Government's national and international climate change commitments. The purpose, scope, and analytical framework for this legal analysis are presented in Chapter 1 and Annex I.


There are few things cuter than a grown man getting excited over a "cool" lunch. I had a day off of Mr W's bento packing yesterday when high winds and low temperatures kept them from being able to work outside. But he's back at it today with another lunch.
Leftovers to the rescue once again. Mr W has some leftover egg noodles with shredded red wine beef and mushrooms, some Super Simple Garlic Bread with some colby jack cheese chunks, fresh pineapple and grapes and a salad made of romaine, apples, cranberries, pecans and shavings of asiago cheese.


Digital signatures, like physical signatures, can verify that a specific user affixed their signature to a document and they can also verify that the document is the same as when the user affixed the digital signature. Digital signature systems (DSS) use public key cryptography methods to create digital signatures. The integrity of the digital signature is tied to the security of the user's private key. As long as the user's private key is secure, then only the user can affix their digital signature to a document. In this paper we examine methods and risks involved in creating digital signatures on workstations other than the user's primary workstation. The challenge is to allow the user to create a digital signature, which requires their private key, at workstations where we can not guarantee the key's security.


text:
Media > Television > Ten Things We Learned During Season One of Game of Thrones
Ten Things We Learned During Season One of Game of Thrones
By Scott Tunstall on June 23rd, 2011
Season one of Game of Thrones came to a rousing conclusion on Sunday night. Needless to say, I'll be in serious withdrawal until chapter two premieres next spring. It's almost impossible to summarize all that did and didn't happen during the first ten episodes of this epic series. Instead, I'll cherry-pick some things I learned while watching the best inaugural season of an HBO show since The Sopranos.
Dire Wolves are badass
What little we saw of these mysterious, deadly creatures of the North was enough to whet our appetites for what I anticipate will be massive carnage in season two. I love the fact that each wolf seems to mirror the personality of their Stark owner. Ghost, the runt of the litter, is a silent beast seething with rage, just like the bastard Jon Snow. Grey Wind, a loyal warrior that allegedly killed ten of Jaime Lannister's soldiers, is a perfect familiar for Robb, the King of the North. Nymeria is fearless and fiercely independent, much like Arya. Methinks the dire wolves will assume a larger role in the future.
The Lannisters are one freaky family
I suppose it's not an accident the most normal of the Lannister clan is the so-called outcast, Tyrion "The Imp." The rest of the brood are a bunch of incestuous, narcissistic villains hungry for power. Not only does Cersei bang twin brother Jaime, but she also dips her toe into the family gene pool with cousin Lancel. As a whole, they are very Roman-like in their duplicitous, depraved behavior. Seeing them crushed one by one will be very satisfying, although something tells me they won't be disposed of easily.
Never trust a witch
Especially one gang-raped by Dothraki warriors. Daenerys Targaryen (aka Khaleesi) and Khal Drogo's plans to conquer the Seven Kingdoms side-by-side were smashed to pieces once Drogo fell ill, and the Maegi Mirri Maz Duur was called upon to save his life. A dead newborn son and a resurrected zombie for a husband wasn't what Khaleesi had in mind when she asked the witch for help. However, the "Stormborn" gets the last laugh in a big, big way.
Arya is going to be a problem
And I mean that in a good way. Besides Tyrion, who I'll get to shortly, Arya was my favorite character in season one. She is very much her father's daughter, but possesses one thing her daddy lacked: guile. Her hatred for the Lannisters reached its boiling point after Ned's execution. Stripped of innocence, this bullheaded little girl seems destined for great things. If she can harness her rage, Arya will become a force to be reckoned with. Nothing would please me more than seeing her drive a sword into Joffrey's throat.
Boy Kings are douchebags
Speaking of Joffrey. Has there been a more hateable teenager on television in recent years than this tow-headed prick? I can't think of one. The mutant offspring of Jaime and Cersei is a demented fiend driven by bloodlust. With so many parties vying for control, his reign on the Iron Throne seems fleeting. Perhaps that's just wishful thinking on my part. Tyrion being anointed Hand of the King in the finale is intriguing. It should make for some explosive confrontations between "The Imp" and the nephew he detests.
Breastfeeding past the age of 2 isn't advisable
Lysa Arryn and her son Robert's creepy oedipal relationship is one of the strangest in the GoT universe. The sight of the six-year-old brat suckling from his mother's breast is disturbing on so many levels. I have no idea what becomes of the sickly lad, but I can do without him feasting on momma's milk in season two.
The Seven Kingdoms is chock-full of hot whores
From the firecrotched Ros to Littlefinger's bordello of babes, there doesn't appear to be a shortage of hot looking whores for the men (and women) of the Seven Kingdoms to sample. Gratuitous nudity is key to any sword and sorcery series, so the presence of these skilled practitioners in the sexual arts is a welcome reprieve to all the beheadings and backstabbings that permeate the land.
Peter Dinklage deserves every acting award in the world
Anyone who has seen The Station Agent or Nip/Tuck already knows Dinklage is a fantastic actor, but GoT has provided him a role befitting his numerous talents. Credit author George R.R. Martin for crafting such a sharp, witty character capable of charming and/or scheming his way out of the direst of situations. Dinklage nailed every single line of dialog and ended up stealing the majority of the episodes, even when relegated to a lesser story thread. The Emmy committee should have their heads encased in molten gold if Dinklage doesn't win.
Ned Stark is better off dead
I know, I know, we're all still upset over Ned's premature exit. I feel bad for Sean Bean, who deserves a meaty part on a long-running series. That said, I don't feel bad for Ned. Why? Because he was totally unprepared and ill-equipped to play the "Game of Thrones." He put honor before logic, which is admirable, but also extremely naive. Poor Ned was duped at every turn by those he was warned not to trust. Bottom line: he got what he deserved. Besides, his death was a necessary catalyst for the Hell that is about to be unleashed on all of Westeros.
Dragon eggs make the ultimate MacGuffin
From the first moment the three dragon eggs appeared in episode 1, I had a suspicion they would one day hatch. Khaleesi's obsession with them, and dragons in general, was intricately weaved by the creative team throughout the remaining installments. A lingering shot of the eggs nestled in their box; a tale from long ago regaling the last of the dragons; the enormous skull in the dungeons at King's Landing.
All these snippets served as foreshadowing devices for the final scene in season one. A scene that defines the term "kick-ass." I admit, I let out a "Yeah!" and pumped my fist when that baby dragon crawled atop Khaleesi's shoulder and announced its arrival.
A memorable conclusion to a memorable ten weeks of television.


Daniel serves as a transformation catalyst focused on expanding agency capabilities to deliver growth for brands. He has operated on both global and regional levels at brand, digital, database marketing, experiential, and B2B organizations; as an architect of modern approaches to digital storytelling, brand experiences, and data-driven creativity. As a champion of gender, cultural, and creative diversity, his mentorship and management discipline has produced next generation creative leadership empowered to succeed in a new age of marketing communications and relationship management.
His work, and that of his teams, have earned multiple Cannes Lions, with inclusion in the permanent collection of New York's Museum of Modern Art.


Like many, I have lived through times of extreme joy and heartbreaking sadness—sometimes inexplicably at the same time. Only through painting and photography can I process and express the simultaneous range of feelings that words cannot explain. Organic shapes and textures lure me into subjects that often combine conflicting emotions like joy and sadness, or confusion and stability. It's the space between opposite emotions that captures my interest. Through my art, I want to create a walkway into a transcendent place where easily defined emotions don't apply. This is the essence of my personal style.
I left Chicago in 1987 and began my professional life as a writer. I took my first photography class in 1989 and fell in love with the art of the photo. In 1993, I began taking drawing and painting classes and workshops from a number of Colorado and Wyoming artists. I started painting with pastels but over the past five years have painted almost exclusively with inks. I think my foray into ink painting is an extension of my love of photography and the printing process.
Inspiration surrounds my home in Colorado, but I also travel to faraway places—always searching for new ways to express complex emotions.
I hope that through this website and my Etsy shop at schwebacharts.etsy.com, I will continue my son Jake's quest for beauty, grace, and meaning. Jake left this earth way too early. He struggled with mental illness almost his entire 22 years. But while here, he shared my love of beauty through the lens and with paint. His experiments with his art committed me to courageous exploration and daring.
A percentage of each sale made on schwebacharts.com and the upcoming jakeschwebach.com (a website still being developed) will be donated to a suicide prevention group. Schwebach Arts is currently interviewing groups to discover the best fit to carry on Jake's legacy, and to advocate for those with mental illness.
Check back to see who we have found for this partnership. If, in the meantime, you purchase from Schwebach Arts, we will set aside 10% of the sale for this future donation.
At the age of 14, Jake held his hands up to me—his mother— on a dark, sultry summer night. He used his index fingers and thumbs to make a square frame, and held this artist's viewfinder up to my eyes so I could see what he was seeing. Through darkened low-hanging branches over Lake Madison in South Dakota, Jake showed me how he would frame a picture of the branches, coconut-white moon and crystalline water. "Look at this picture. So beautiful. When I get my camera, I will be taking shots like these all the time." A few weeks later, Jake got his first 35mm camera, and before he passed away at the age of 22, in November 2015, he held true to that promise. He took thousands of stunning photos on three different continents, of cherished friends, family, animals and any and all objects of elegance. Jake also discovered his passion for environmental activism and social justice as many of his later photos demonstrate. Jake's photographs speak of his quest to find grace in this often unkind world—because at times, Jake suffered great loneliness. Jake's work often reflects his search for hope, for the conviction of things not seen. We are currently developing a website devoted exclusively to Jake's photographs.
Check back on the launch date for Jake's site.


Food sensitivity program that changes your life.
Permanent weight loss, body-bliss plan that re-shapes your life.
Alternative treatments that can save your life.
I just couldn't seem to shake the fog that constantly surrounded me. Within about six weeks after doing the FOODStrong™ for food sensitivities program, my post-nasal drip dried up immeasurably, the tired feeling that dogged me was lifted, my frequent migraines lessened, and my weight, which I've fought my entire life, stabilized. I now have focus, concentration, and, best of all, more energy. It's amazing how seemingly small changes in the way I eat have made such a large impact on my life.
I HAVE LOST 40 POUNDS AND HAVE BEEN ABLE TO KEEP IT OFF!
I was overweight, constantly bloated, lethargic, depressed, and unable to lose weight no matter what I did. Within two weeks of doing FOODStrong™ for food sensitivities, my energy improved 100%, I began to lose weight, and the bloated look went away almost immediately. Jill help me understand the effects of food on my body and how to change my negative behaviors associated with food. I also used the diet as a jumping off point for living the healthy and active lifestyle I lead today.
Since childhood, I have suffered from a variety of ailments, and it seemed with each passing year they became worse. I experienced bad side effects from medications, including anaphylaxis and liver damage. What a mess, right? Doing FOODStrong™ for food sensitivities was one of the best decisions I have ever made. Jill is amazing! She listened to my concerns and her nutrition guidance was the only thing that improved my health!
WITHIN FOUR WEEKS, MY SKIN WAS 75% BETTER!
Before I called Jill, I had been suffering from hives on my chest and face for years. After working with an allergist, the hives were only getting worse. I was starting to feel frantic! All my lab tests came back negative, so I decided to do Jill's FOODStrong™ for food sensitivities. I followed the food plan very strictly as I was desperate for results. Jill also had me do a heavy metal chelation and begin anti-inflammatory supplements. Within six months, the hives disappeared completely. I'm now wearing jewelry without allergic reactions. Jill's tremendous amount of knowledge and resources have solved some very difficult problems for me.
Almost there! One more step to gain instant access. Just fill in your first name and email.
YOU'LL ALSO GET GREAT LIFESTYLE CHANGE TIPS AND STRATEGIES DELIVERED TO YOUR INBOX ABOUT ONCE A WEEK. DON'T LIKE THEM? NO PROBLEM. UNSUBSCRIBE WHENEVER YOU LIKE. OH … AND WE'LL NEVER SHARE … PLEDGE ON PIZZA!