Design and brand strategy is powerful work, capable of influencing people to act based on an emotional connection. We are aware of this, and are therefore extremely strategic with whom we partner with. Please consider the following when considering whether we are an appropriate fit.
Industry and technology are powerful forces of societal change. With change comes the ethical dilemma: are you profiting off customer data? Will achieving success result in putting someone out of a job?
The importance of these questions contribute towards our society and the natural flow of innovation. How transparent are you? Through transparency, we win trust and together ready ourselves for the impactful shifts associated with innovation. Let's design to win.
If you're interested in why we care about ethics so much, check out this article. It discusses how design, the act of solving problems and encouraging human interaction, is an inherently ethical question. One we are honored to take seriously.
I. We care about consumer transparency and understand that it is in direct support of a successful business.
II. Your technology or service positively impacts lives. Powerfully.
We are acutely interested in the industries that are transforming the natural flow of accessibility. Healthcare, environmentalism, consciousness technology. We believe that design and effective messaging has been reserved for the likes of consumer goods alone since the advent of the advertising industry in the 20th century, and it's time to use that same emotional draw toward the industries that can fundamentally change the way this world functions.
Sound like you? Then please, reach out.
We're designers. The pursuit creativity is our philosopher's stone; An endless cycle of learning and mentoring. It's great. It's movement; and movement is life.
We're here to breathe life and personality into your company; One that's trustworthy, emotionally consistent, and thriving with culture. We do that by working together. Communication is key, so we will try our best to meet with you, face-to-face and get things going. What takes place in these meetings? We pull up our sleeves, talk shop, and get into our discoveries and findings. It's nothing short of magic.
Well we certainly hope so. Let's talk.
Thank you! We're looking forward to reading over this and we'll be in touch shortly (give us a couple days, yea?).


One way to really challenge our target audience with such riddles and games is through the concept of an escape room. However, the traditional escape room concept has a limitation in that it is only available at a single fixed location, and therefore not really suitable for a nationwide recruitment campaign. What if we could use technology to eliminate this fact and allow everybody to experience our escape room from the comfort of their own home?
In a mobile augmented reality (AR) experience, available in the Apple and Google Play Store, we turn your own room at home into an Escape Room. We teamed up with expert teams at ABN AMRO and with Sherlocked (the mystery experts behind some of the best Escape Rooms on the planet) to produce the storyline and challenges. AR technology is combined with video assets to bring this story to life: In 2028, "Money" has become fully digital and is secured on the blockchain. But when the blockchain turns out to not be as safe as previously thought, you are called upon as an IT expert to help find the leak and save the world from financial disaster. Once you've set up your "holodesk" and "infowall," the game takes you past several challenges that have to be solved around themes that include Artificial Intelligence, Info-security, Cryptocurrency and Blockchain.
The Lockdown is set in the year 2028. As money has been completely digitised, people maintain their finances with a smart contract called "The Lantern Wallet." When suddenly people worldwide find themselves unable to access their cryptocurrency, chaos ensues. Players have to solve challenges, with themes such as information security and blockchain, to prevent a total financial meltdown. Through several stages, the players can ultimately help Interpol pinpoint the hacker's residence. Players can select the difficulty of the game by choosing between the various available roads to victory.
The game's puzzle mechanics were designed by Sherlocked, famous for its popular escape rooms in the Amsterdam Beurs van Berlage. In addition to the app, the campaign featuring The Lockdown includes online videos, rich media banners and a cinema trailer.


Isaiah 30 – We are obstinate, but thankfully God is overwhelmingly compassionate. Isaiah's prophecy rings eerily true today. Listen in and be stirred yet comforted.
Hebrews 10:31 – The first Good Friday was a dreadful day for Jesus, but it was the basis for our acceptance before God. It's a dreadful thing to fall into the hands of the living God, but, thankfully, Jesus went there for us.
Mark 5:21-43 – Jesus is Lord over everything – including life and death. This is great news for His people. We needn't fear the things of this life or even death itself.
What is Evangelism (And what it is not)?
Gen 1:27-28 & Deut 7:7-9 – "Evangelism" is a word that generates anxiety for most Christians. Understanding what evangelism is (and what it isn't!), is the first step towards faithfulness (no matter how we might feel!).
Genesis 41-44 – One day Joseph is in prison and the next he's practically the most powerful man in the world! In Joseph's story, we see just how wonderful and surprising God's workings are. We're urged to praise him and to… repent.
1 Peter 4:19 – Suffering inevitably comes upon God's people. We must entrust ourselves to God and continue to do good.
Romans 12:19 – Is there any place for vengeance in the Christian's life? No. Do we often, though, seek the downfall of others (at least in our minds!)? In Romans, Paul gives us helpful principles to fight against the urge to "get back" at that person. Listen and grow.
Gen 30:25-31:55 – How aware are you of God's working in your life on a daily basis? Jacob's up to his old tricks again, but God continues to provide for and protect Jacob in spite of Jacob. Will Jacob grow in God awareness? Will you?
Gen 29:14-30:24 – A peek into Jacob's family life is sad, but all the time, God's promise is growing. Is your life similarly "messy?" Remembering that God is at work changes everything.
Genesis 28:10-29:14a – Do God's promises still apply to a trickster like Jacob? Surprisingly, yes. As God first speaks to Jacob, we're challenged to re-think our priorities and pay attention to the outworking of God's plan in our lives. God is near to tricksters.
Genesis 22 – Unbelievably, God tells Abraham to kill his son Isaac and offer him as a burnt offering. What will Abraham do? Through Abraham and Isaac we learn invaluable lessons about faith and God's grand plan to provide a substitute for sinners.
Genesis 18-19 – As we hear of God's terrifying judgement upon Sodom and Gomorrah, we're reminded that God alone knows the path to life. Our passage today gives us 3 signposts along that path.
Genesis 12:10-20 – Can we trust God when the wheels seem to come off? From Abram's journey, we learn that despite all threats, God remains faithful.
Genesis 9:1-10:32 – The worldwide flood changed so much, yet in many ways, things stayed exactly the same.


At Windsor Pacific Property Management, we specialize in single-family homes, townhomes, and condominiums. We are a full-service property management company which has been in business since 1987. Our goal is to set a new standard for property management, and to exceed each customer's expectations. Whether you're a landlord, an investor, or a tenant, we're here to help you have a rewarding and stress-free rental experience.
The properties we manage can be found in some of Contra Costa County's most diverse and desirable areas. We work in San Ramon, Danville, Blackhawk, Dublin, Pleasanton, Castro Valley, Livermore, Alamo, Walnut creek, Lafayette, Moraga, Orinda, Pleasant Hill, Martinez, Concord, Clayton, and nearby areas.
WHY SHOULD OWNERS LIKE YOU WORK WITH WINDSOR PACIFIC?
When it comes to property management in Contra Costa, owners and landlords like you have a lot of options. Why should you work with us at Windsor Pacific? Well, we do things a little differently. We're focused on your individual needs, and we believe setting high standards and delivering services you simply couldn't find anywhere else.
We're a boutique company, ready to match what we do to what you need.
High quality oversight is important to us, and part of everything we do.
Our technology is innovative and user-friendly.
We work with the best, most qualified vendors in the area.
Eviction coordination is available if your tenant stops paying rent.
We offer our clients both leasing services and complete management services.
Our leasing services will limit your vacancy time, provide a strategic and results-oriented marketing plan, and place a good tenant who will pay your rent and take care of your property. You can expect us to show your property, post professional signs, and provide an easy online application for potential tenants.When full-service management is what you need for your rental home in San Ramon, Danville, Dublin, Pleasanton, Livermore, or the surrounding areas, we'll provide all of our normal leasing services as well as daily oversight and protection.
We collect rent online, supervise maintenance without any mark-ups, provide professional accounting and statements, and coordinate the eviction process if necessary. We handle all tenant relations, leaving you free to live your life and collect your rent checks.
Superior property management in zip codes 94582, 94583, 94506, 94526, 94568, 94588, 94566, and 94550.
Protecting what may be your biggest asset starts with good tenant screening. You can count on us to run exhaustive credit checks, look for prior evictions, verify employment and income, and talk to current and former landlords.
We screen tenants in San Ramon, Danville, Dublin, Pleasanton, Livermore, and the surrounding areas.
At Windsor Pacific Property Management, we only work with vendors who are licensed, insured, and great at what they do. They're available to us 24 hours a day, and they provide us with competitive pricing because of our relationships.
Rental property maintenance for your investment in zip codes 94582, 94583, 94506, 94526, 94568, 94588, 94566, and 94550.
Your property deserves accountability, transparency, and oversight. We provide it. With preventative maintenance and ongoing reports that are especially useful for out-of-state owners, you'll always know that your investment home is safe and performing as well as it should.
We are local property management experts.
Our team of Contra Costa County property managers know your neighborhood. They live and work in cities like Dublin, Livermore, and Pleasanton, and they understand what you need to succeed and what your tenants need in order to feel at home.Choosing a big-box chain management company often means that you're assigned a property manager who doesn't know you and doesn't know your property. We like our small size. It's an asset that allows us to put all of our resources and knowledge into managing properties like yours. We're here to answer your calls and respond to your needs.
Windsor Pacific was always prompt in addressing each and every problem and kept us informed as to the resolution. In the service industry this is an important factor and they performed to our highest expectations.
Are you currently renting from us in San Ramon, Danville, Dublin, Pleasanton, Livermore, or the surrounding areas?
Tenants renting from Windsor Pacific know that we're here to make the rental experience as enjoyable and stress-free as possible. It's important to be happy with your home. We try to make life as easy as possible for our tenants. The tenant portal provides a way to pay rent online and our 24-hour maintenance center is always available.
Need a home in zip codes 94582, 94583, 94506, 94526, 94568, 94588, 94566, 94550?
Maybe you're looking for a single-family home in Pleasanton or a townhouse in San Ramon. Whatever your list of needs and desires includes, we can find something to fit your lifestyle. Talk to us about your budget and your desired neighborhoods. We're local Contra Costa County property management experts, and we'd love to help you find your next home.
Jackie is on top of things. Our issue has been addressed promptly and has been followed up quickly and efficiently. Her response time to questions and problems is immediate. She runs her business very professionally and she seems to be well connected. Thank you!


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Home › The Charlatans - A Head Full Of Ideas (Transparent Blue 6LP Boxset (5LP+7") + Signed Poster)
The Charlatans - A Head Full Of Ideas (Transparent Blue 6LP Boxset (5LP+7") + Signed Poster)
Label: Then Records
Catalogue No: THEN1LPXX
5LP + 7" Vinyl Set, SIGNED Exclusive Poster, 12 Page Fan Booklet, Limited Transparent Blue Vinyl.
The Charlatans proudly announce their 30th Anniversary tour and three accompanying vinyl variants, including this 6 vinyl boxset (5LP + 7") option. Released on Then Recordings these releases sum up their remarkable progress from 1990 Manchester scene hopefuls to one of the UK's most enduring and best-loved bands. The accompanying tour begins at Belfast, Limelight 22/11/21 and finishes in Aberdeen on 20/12/21.
The band have notched up 13 Top 40 studio albums - three of them number ones - alongside 22 hit singles, four of them top 10. The rollercoaster highs have been accompanied by some shattering lows, any which one of them could have felled a less resilient band, from nervous breakdowns to near bankruptcy and the deaths of two founder members.
Somehow, they have not just carried on but adapted and transformed. The classic Charlatans sound - driving Hammond organ, Northern Soul and house-influenced rhythms, swaggering guitars and Tim Burgess's sunny, yet somehow yearning vocal - is instantly recognisable. And in spite of everything they have been through their music is now more relevant than ever. The Guardian described their last album, Different Days as "one of their best ever".
This limited box set, is a diverse collection portrayed over five Transparent blue vinyl LP's, spanning their hits, classic live performances, unheard demo's and rarities and remixes. Within the box will also be an exclusive Original Demo's 7" featuring 'Indian Rope'/'The Only One I Know', as well as a signed print of a tour poster from the early 90's, a booklet featuring unseen photographs and sleeve notes by friend and journalist Dave Simpson. There will also be triple vinyl LP version and 2CD deluxe of the box set featuring the hits albums plus the live album, and finally a cd or vinyl of just the hits albums.
Their iconic and hugely adored live track One To Another (circa 1997) provides the titles for the individual vinyl collection within the box set. Each piece of vinyl is named after a lyric from the song.
The team at Wax and Beans are incredibly excited about this release, we rank them amongst our favourite bands, having produced a tonne of amazing tracks and some of the best live gigs we've ever attended.
A HEAD FULL OF IDEAS (BEST OF)
1. The Only One I Know
2 Weirdo
3. Can't Get out of Bed
4. Jesus Hairdo
5. Just When You're Thinking Things Over
6. North Country Boy
7. Tellin' Stories
8. One to Another
9. How High
10. Impossible
11. Forever
12. Love is the Key
13. A Man Needs to be Told
14. Up at The Lake
15. Blackened Blue Eyes
16. Oh Vanity
17. My Foolish Pride
18. Come Home Baby
19. Let the Good Times be Never Ending
20. Plastic Machinery
21. Totally Eclipsing
TRUST IS FOR BELIEVERS (LIVE)
1. Polar Bear (Blackburn, King Georges Hall. November 1990 - BBC Radio 1)
2. Indian Rope (Reading Festival 1992 - BBC Radio 1)
3. Can't Even Be Bothered (Reading Festival 1992 - BBC Radio 1)
4. Can't Get Out of Bed (Glasgow Tramway, Sound City 1994 - BBC Radio1)
5. I Never Want an Easy Life (If Me and Him Were Ever to Get There) (Glasgow Tramway, Sound City 1994 - BBC Radio1)
6. Then (Glastonbury Festival 1995 - BBC Radio 1)
7. Here Comes a Soul Saver (Hultsfred Festival, Sweden 1997)
8. My Beautiful Friend (Delamare Forest, Cheshire 2007)
9. The Blind Stagger (Delamare Forest, Cheshire 2007)
10. Sproston Green (Reading Festival 1999 - BBC Radio 1)
PLEASED TO MEET YOU (DEMOS) (***EXCLUSIVE TO BOX SET***)
1. C'mon C'Mon (Demo Version)
2. Sleepy Little Sunshine Boy (Desk Mix Version)
3. Dardanella (Demo Version)
4. So Oh (Demo Version)
5. Always on my Mind (Demo Version)
6. Everybody Ha Ha (Demo Version)
7. Commuter Computer (Demo Version)
8. Crystal Eyes (Demo Version)
9. Polar Bear (Demo Version)
10. I Need You To Know (Demo Version)
ONE TO ANOTHER (REMIXES) (***EXCLUSIVE TO BOX SET***)
1. Plastic Machinery (Sleaford Mods Remix)
2. Nine Acre Dust (Chemical Brothers Remix)
3. So Oh (Brian Jonestown Massacre Remix)
4. Tellin' Stories (The Go! Team Remix) **unreleased**
5. Trouble Understanding (Norman Cook Remix)
6. My Beautiful Friend (Jagz Kooner Remix)
7. Hey Sunrise (The Orb Remix) **unreleased**
8. You're So Pretty, We're So Pretty (Lo Fidelity Allstars Remix)
BONUS DEMOS 7" (***EXCLUSIVE TO BOX SET***)
1. Indian Rope (Demo)
2. The Only One I Know (Demo)

redpajama_set_name: RedPajamaCommonCrawl


The main advantage of this approach is that, like with "real" sum types, you get compile-time checking that you've handled every case. It also seems to mesh better with Go's interfaces, since there's no need to introduce a dummy method so the interface can work as a tag.
On the other hand, bypassing Go's type switch construct is a little disappointing, since the automatic casting in type switches makes the syntax pretty clean.
It's also interesting to see that having "r" as an assignable return value comes in handy here (since you can't return from inside a lambda). In Java, I'd solve the same problem by making Visit usable as an expression (like case expressions in functional languages) by giving it a parameterized return type, but the lack of generics makes that annoying in Go.


video | Boston Square Community Bikes | a free, do-it-yourself bicycle shop.
Boston Square Community Bikes | a free, do-it-yourself bicycle shop.
I've done it. I've done it. Let's back up. Hello, I'm Ryan. I'm a mechanic at Boston Square Community Bikes. I work the Monday and Saturday shifts. I've included a photo to get ourselves more acquainted. I'm the bigger one. The one on the right.
I would like to walk you through my latest build. It's no secret that Boston Square is a great (cheap) place to build up bikes. It's also a great place to meet others, help others, learn from others; the list just goes on. I'm going to be putting together some videos that hopefully somebody finds useful but also show my latest acquisition. Jo also got a new bike. That's him on the right. Tom, is on the left. So I hope to have you follow my progress with the new bike. Here's the right now.
But very soon I'm going to strip it and clean it up. It is dirty. I will be posting reviews and trying some new things out. I'm planning on upgrading certain components to more modern version, don't tell Jo. I'm even thinking of adding carbon fiber…shhhh. REALLY, don't tell Jo. 1970 all steel beauty Fuji with carbon? What! Personally I don't love cottered cranks. You might, I don't. They are out. I'm thinking a modern stem and handlebars so the bars are a little large diameter for better ergonomics. We'll see. Plus did you notice the hand built velocity rims? Support your local people right? Lastly the color. Gorgeous. Love it. couple of scrapes and I may do a couple of light touch-ups but I love orange. Not till I got older did I have a favorite color but now that I'm older and wiser…orange is clearly the best. Stop into the shop and talk to me about this or if you need help with your next project I'd love to work with you.


Blitz Gràcia is a coworking space of 220 m2 located in the Gràcia neighbourhood that promotes collaboration, synergies and familiar work atmosphere.
The coworking can boast of having great views to Barcelona city and the sea, thanks to the 2 terraces. The work area is an open space with natural light, without divisions, having a big room to take a break and a nice meeting room.


A fun afternoon of sketching from different live set ups at the Washington Studio School. Once a year they set up scenarios on each floor and students and the public are invited to draw! This one is charcoal and graphite on paper.
This one is also charcoal on paper. Sometimes the last sketch in the last twenty minutes is the most satisfying..


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« Green group praises Cambodian ban on sand export
China provides 73m dollars loan to Cambodia for road construction »
Response to article: Foreign Minister Critical of UNTAC's efforts
By Vireak In
IIn the article "Foreign Minister Critical of Untac's Efforts" where Cambodia's foreign minister Hor Namhong said "The UN's transitional authority, which occupied Cambodia in the early 1990s, did little for the country except put an election in place in 1993, but failed to end the country's war".
As a former UN staff in Cambodia, I find his comment somewhat offensive. I expect more from the leader. I join "Lao Monghay, a former member of the KPNLF who is now a researcher for the Asian Human Rights Commission, who said Hor Namhong's criticism of UNTAC overlooked the work the peacekeepers did accomplish".
Foreign minister Hor Namhong ignore the humanitarian work which UNTAC carry out before the 1993 election, the repatriation of some 360,000 refugees from camps along Khmer-Thai border. Most of the refugees were civilians, rice farmers from north-western Cambodia, who had sought refuge on the Thai border from the ongoing conflicts following the collapse of the Khmer Rouge regime following the invasion of the Vietnamese in 1979. Some refugees escape from the government that mean to provide them sanctuary, but fail to do so, instead people face with intimidation, starvation just to name a few, wonder why foreign minister Hor Namhong fail to acknowledge such a wonderful job by UNTACT.
At the time, the repatriation was considered to be the biggest operation ever undertaken by UN, many critic do not believe it is possible to carry out such an operation. Repatriate 360, 000 from Khmer-Thai border and then integrate the returnees into the community of their choice, issue the identification cards for all returnees so they are ready for the 1993 election.
I still remember the joy when the first convoy across the border and make their way to Sisophon, many of the children were born in the Camp and return to the country that they never knew, but they call it home. I still remember when we accompany the first envoy to Stung Treng, the road was so bad that we have make our trip by Helicopter. I still remember when we accompany returnee to the no-go zone, yet it was the wish of the returnees. I still remember how taught it was to negotiate land for returnees, some allocated land were so heavy laid with land-mine, thank to Cambodian Mine Action Centre (CMAC) returnees can settle safely in the allocated land.
Under the leadership of the late special envoy Sérgio Vieira de Mello, the repatriation operation was a very successful one. Sérgio Vieira de Mello (March 15, 1948 – August 19, 2003) was a Brazilian United Nations (UN) diplomat who worked for the UN for more than 34 years, earning respect and praise around the world for his efforts in the humanitarian and political programs of the UN. He was killed in the Canal Hotel Bombing in Iraq along with 21 other members of his staff on 19 August 2003 while working as the Secretary-General's Special Representative in Iraq. The man whom I greatly admire and have the pleasure to work with.
It is undeniable that UNTAC has done so much for Cambodia, as in the word of President Sam Rainsy from the same article "Beyond the elections, the UN and the accords helped oust a Vietnamese force that would have had people living under a communist regime even today".
cambodia, cambodian refugee, sam rainsy
This entry was posted on Saturday, May 16th, 2009, 3:15 am and is filed under cambodian politic. You can follow any responses to this entry through RSS 2.0. You can leave a response, or trackback from your own site.


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Lac-Saint-Jean—Roberval fut une circonscription électorale fédérale de la région du Saguenay—Lac-Saint-Jean au Québec. Elle fut représentée de 1935 à 1949.

La circonscription a été créée en 1933 avec une partie de Lac-St-Jean. Abolie en 1947, elle fut reditribuée parmi Lac-Saint-Jean et Roberval.

Lors des trois élections disputées dans cette circonscription, Joseph-Léonard Duguay,  député fédéral de Lac-St-Jean et député provincial de Lac-Saint-Jean, tenta de se faire élire sans succès, d'abord sous la bannière conservatrice en 1935, sous celle du Gouvernement national en 1940 et à titre de candidat indépendant en 1945.

Géographie
En 1933, la circonscription de Lac-Saint-Jean—Roberval comprenait:

 Les comtés de Lac-Saint-Jean-Est et Lac-Saint-Jean-Ouest

Députés

 1935-1945 — Armand Sylvestre, PLC
 1945-1949 — Joseph-Alfred Dion, PLC Ind.

PLC = Parti libéral du Canada

Lien externe
Circonscription de Lac-Saint-Jean—Roberval — Chambre des communes du Canada

Ancienne circonscription fédérale au Québec

redpajama_set_name: RedPajamaWikipedia


The Baltimore institution wants to support entrepreneurs – both on campus and in Baltimore. We talked to newly-named director Wendy Bolger about the center's social mission.
On the campus of Loyola University Maryland.
Led by recently-named director Wendy Bolger, the center will provide programming and resources that support entrepreneurs who are already getting started at the North Baltimore campus. It also has a wider mission to reach out to the wider Baltimore community as it looks to contribute to job and wealth creation in the city. The center is being supported with a $1.46 million gift from biotech executive Nick Simon and the Baltimore-based Frank family, according to Loyola.
Bolger said the center will seek to create space for all, but she identified a focus lying in harnessing the approaches that lead to new ventures for social good. That makes sense, given the university's Jesuit roots and history of service, as well as their goal to help the city.
"Innovation is what will better the lives of people across the city, and ultimately transform Baltimore, and Loyola will play a role in that transformation through the center," Bolger said in Loyola's announcement.
Loyola has helped attract and educate a number of Baltimore entrepreneurs, and part of the center's task will be to serve as an umbrella of resources for community members for the university's available resources that are available. "We're really building on momentum that has been growing for a long time at Loyola," Bolger said this week, adding that the conversations, adding that whether it's student entrepreneurs or the library's makerspace, entrepreneurship and innovation activity has been taking place around campus. Conversations and working groups have been developing over the last year leading up to the launch, she said.
An interdisciplinary Entrepreneurship Program that is part of the university's course offerings, which includes a minor.
An idea lab to provide for prototyping, which builds on an existing makerspace at the university library.
Baltipreneurs' Institute supporting local entrepreneurs, providing connections to students, faculty and alumni.
In the future, plans are also in the works to launch an accelerator.
Bolger, who previously directed innovation strategy at Share Our Strength's No Kid Hungry campaign, said the opportunity immediately resonated with her. "It's one of those times when it was, 'This is the best job description I've ever read.'" The mission to help the whole community and role in starting a new center especially stood out.
Students, of course, are also top-of-mind. They will also be involved in running the center, and Bolger wants to create a collaborative environment. When it comes to creating social change, "It's really important to me that everyone feels like there are tools within innovation that they can use," she said.
As we noted in this week's On the Market column, Loyola is also seeking an entrepreneur in residence.


Victorian Charm – Negotiation Success!
Our clients couldn't be happier with this Bayside family home in the perfect location. Walking distance to the areas key schools this home is perfectly placed. Secured before auction our clients couldn't be happier.
A wide panorama over Wedding Cake Island and the eastern coastline creates a magical backdrop to this luxurious beachfront residence.


The online application forms will be available soon on the official website of the bank www.ucobank.com before the last date.
Post name Probationary Officer (PO), Specialist Officer (SO), Clerk, Attender, Office Assistant, etc.
UCO Bank will soon announce the notification for hiring the candidates in the post of Probationary Officer (PO). Interested candidates need to apply online through the prescribed link mentioned above.
Candidates must have a degree of graduation from a recognised board.
The age of aspirants must be between 20- 30 years and the relaxation is provided as per the govt. norms to the reserved category aspirants.
Selection process Candidates should have appeared in IBPS Bank SO 2018 Exam and have cleared with standard scores, they are then called for the interview round.
The Applicants willing to seek the post of clerk in UCO Bank should possess the following eligibilities.
Contenders should have a min degree of graduation from a recognised university or equivalent qualification.
20- 28 years and relaxation in age is provided as per the rules of govt.
The news for the recruitment of sweepers will be released soon on the official web page.
According to the released notification, there are 100 vacancies for the post of Chartered Accountant in UCO bank for the year 2018- 19. Candidates can apply online before the last date.
Willing aspirants who are waiting for the post of Peon in UCO Bank are advised to check the official page of bank thoroughly for the latest updates.
As soon as the board will issue any notification candidates are provided with all the essential information in this page.


Chakra meditation is done by understanding the cause and the effect of the emotions in our body. Healing the cause involves brining one's attention to the state of complete awareness. For healing the effects there are various guided meditation practices that are helpful- White Chakra light meditation, Inner Vision Meditation etc. At Mind Valley Academy these meditation practices are imparted through there video tutorials that one can take up from their home at any comfortable time. Chakra healing is done through meditation with proper instructions and guidance.
One of the most powerful ways of doing Chakra healing is through the Affirmations. These are the positive statements that are used to imbibe the energies of strengthening and healing ourselves. One statement at a time is used to create the effect of healing.
Massaging is done keeping in mind the position of the chakras in such a way that the blood circulation improves on these points. When the blood cells get activated in those chakra points, the Chakra healing generates.
Just like the colour therapy, Chakra healing is also carried out through the colours and their aura. Each colour has a different vibration and energy radiation that have significant effect on our mood, emotions, thoughts and actions. The practitioner is guided about these auras and energies to create the harmony and balance in their co-existence. They are instructed to use these colours in their house, work place by different ways. One can even wear different colours to generate the vibrations for the power of healing through them.
Various sound waves come at varying frequencies. These musical sounds with different frequencies are used to create healing of chakras. As per their position, these chakras respond to sound waves and get healed. Some of the popular techniques to do Chakra healing through music are – Solfeggio and use of Tibetan singing bowls.
The chakra stones consist of specific vibrations and colours which are used significantly for varying chakras. It is mentioned that most of the stones are specified for some certain chakras only but there are a few used for healing multiple chakras too such as Clear quartz stone.
Yoga is directly linked with the presence of Chakras in our body. There are various Yoga asanas and postures which are used to give maximum momentum and stability to the chakras to generate positive energy through them. Practices such as pranayam are used for allowing maximum oxygen to reach the chakras and bring about vitality and freshness in life.


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Is there another all-woman vocal group who would be a good match for a Verzuz session with En Vogue?
Was there any foul play involved in Kurt Cobain's death as indicated by his newly-released FBI files?Â
En Vogue Will Perform A Live Streamed Concert This Friday
The iconic vocal group En Vogue will perform a live-streamed concert this Friday. It was 30 years ago when they emerged with their debut album Born To Sing which contained their number one hit "Hold On." They would have more important moments in the '90s with "Free Your Mind," "My Lovin' (You're Never Gonna Get It)," "Don't Let Go (Love)" and "Free Your Mind." Their journey in the '90s as possessors of essential R&B hits, unique harmonies, beauty and an enduring stage presence made them one of the top girl groups to ever hold a microphone. They recently celebrated their 30th anniversary with a performance of "Free Your Mind" at the Billboard Music Awards.Â
Cindy Herron, Terry Ellis and Rhona Bennett will perform on the Sessions Live stage and will be filmed by six cameras. The show takes place on December 11th at 6 PM PST and 9 PM ET from the Champion Site + Sound Studio featuring a 9-foot LED wall. The 45-minute set will be their first time performing since being in quarantine lockdown.Â
There are tickets for the show, virtual after-party and question and answer session on sale now. The general admission tickets are $7.50 and can be purchased here.Â
The group will also perform at Dick Clark's New Year's Rockin' New Year's Eve on December 31st.
Is Dawn Robinson right that only the four original members of En Vogue minus Rhona Bennett should participate in a possible reunion to celebrate this year's 30th anniversary of their debut album Born To Sing?
Is Summer Walker right that R&B is better than hip-hop in 2020?Â
Will the Union of Musicians and Allied Workers achieve their Justice at Spotify initiative of one penny per stream?Â
Throwback: En Vogue-Don't Let Go (Love)
En Vogue recorded "Don't Let Go (Love)" for the Set It Off soundtrack in 1996. It had been four years since the release of their successful sophomore album Funky Divas and three since their Runaway Love EP came out. "Don't Let Go (Love)" was used as the lead single from the soundtrack to promote the music and the movie. The group's phenomenal performance of the song was enhanced by the epic visuals it was matched to in the movie. No one can forget En Vogue playing in the background while Jada Pinkett Smith, Queen Latifah, Vivica Fox and Elise Neal try to escape after a bank robbery. The song earned them the most recognition commercially speaking and provided more motivation for the recording of their third album EV3. Dawn Robinson sang lead for the last time before she left for a solo career in 1997. The video featured En Vogue performing for a group of people in New York City, unlike the movie's Los Angeles setting. Another version of the clip had scenes from the movie and actor Mekhi Phifer as a cheating boyfriend. "Don't Let Go (Love)" was also included on EV3's tracklisting. The success of "Don't Let Go (Love)" made it one of the most esteemed songs of the decade.Â
En Vogue's seventh album Electric Cafe with the three woman lineup of Cindy Herron, Terry Ellis and Rhona Bennett came out in 2018. The group's personnel had changed over the years when original members Dawn Robinson and Maxine Jones left at different times. Bennet joined Herron and Ellis in 2004 for the Soul Flower album. In 2019, Jones and Robinson joined the other members on stage for the first time to perform a tribute to Epic Chairman/CEO Sylvia Rhone who was the City Of Hope Spirit Of Life Gala honoree.Â
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text:
FeaturedLifestyle
A mule in a million: Bransby Horses celebrates oldest resident
One of Bransby Horses' oldest residents Ebony the mule celebrates turning 30 this month, making her the oldest and second longest staying equine at the charity.
Ebony – who is the offspring of a female horse/pony (mare) and a male donkey (jack) – was wandering the streets of Gainsborough in Lincolnshire when Bransby Horses were called to her rescue back in 1992.
It wasn't clear if she had escaped from a field or been dumped but, when no one claimed her, the equine welfare charity were there to make sure she received all the love and care she needed.
Bransby Horses were only able to care for Ebony and the thousands of other sick and abandoned horses just like her thanks to the kind donations of its supporters.
Ebony's character and cute looks have earned her legendary status and she is a firm favourite with staff and supporters alike.
Visitor Centre Team Leader, Shell, said: "Everyone loves Ebony. She is such a cheeky little lady who doesn't act her age at all. She has a distinctive voice when she brays and I can tell it's her just from the noise she makes.
"Ebony has very specific care needs, which is why she is in a herd with equines with similar needs. For example, Ebony only has a few teeth and needs her feed adjusting for this so that she can continue to eat well. She needs more than one rug to keep her warm and dry because a mule's coat is not as waterproof as a horse's."
During her early years at Bransby Horses, Ebony was trained to pull a small cart to help with weight management and keep her busy.
Shell added: "She's a very intelligent mule and when she was younger she liked to be doing things rather than just grazing in a field. She's retired now and is happy playing and relaxing in her paddock with her little herd."
On the big day Ebony was presented with an equine friendly cake made from grass nuts, carrots and molasses, which she shared with her companions, 26-year-old Shetland pony Cinderella and 21-year-old Penelope, who is the charity's only other mule.
Ebony was also a Sponsorship Star for many years and still has many supporters who like to send her treats, such as carrots, with their regular donations.
You can visit Ebony on the Visitor Centre Yard at Bransby Horses, LN1 2PH, 10am – 4pm, Wednesday to Sunday, open seven days a week during school holidays.
So, what is a mule?
A mule is a cross between a female horse and a male donkey.
They are unable to reproduce and have their own offspring due to their odd numbers of chromosomes.
Ebony is slightly above the average age for mules but some have been known to live for up to 50 years.
Like donkeys, mules can be very stoic and hide their pain. If something is wrong, it can be difficult to tell as they can tend not to show signs of discomfort.
Mules can be ridden like horses.
Mules are generally less stubborn and more intelligent than donkeys.
Bransby Horses has two mules who can be visited by members of the public; Ebony and Penelope.
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Project to improve water quality of River Freshney set to begin
Work is due to start next week on a key project to improve the water quality of the River Freshney in Grimsby. For around 6...


Large Share: Arugula, Broccoli Leaves, Basil, Mixed Mint, Onion, Celery, Carrots, Grape Tomatoes, Beans.
Large Share: Salad Mix, Kale, Rosemary, Parsley, Lemon Grass, Cabbage, Tomatoes, Squash Mix, Eggplant.
Large Share – Arugula, Salad Mix, Sorrel, Bay Leaves, Garlic Chives, Purple Basil, Heirloom Tomatoes, Medley Mix Baby Heirloom Tomatoes, Eggplant, Leeks.
Medium Share – Salad Mix, Sorrel, Bay Leaves, Garlic Chives, Purple Basil, Heirloom Tomatoes, Medley Mix Baby Heirloom Tomatoes, Peppers.
Small Share – Salad Mix, Sorrel, Bay Leaves, Garlic Chives, Purple Basil, Heirloom Tomatoes, Medley Mix Baby Heirloom Tomatoes, Peppers, Purple Cabbage.


IDBI Bank Limited, Mumbai, Maharashtra, has invited applications from well-qualified and experienced Indian professionals for recruitment 2013, for the post of Faculty (Agri Business).
Candidates' appointment is to be done on contractual basis for a period of one year. Selection of the candidates will be made on the basis of Personal Interview. Candidates short-listed in the initial screening on the basis of academics and work experience will be called for the Personal Interview.
Must have experience in dealing with all types of Agriculture Lending (Direct as well as in-direct lending covering processing, disbursement, follow-up / monitoring etc).
Application Form, duly complete in all respect, along with recent passport size photograph, and attested copies of all relevant certificates, should be send to The General Manager (Recruitment Section), Human Resources Department, IDBI Bank Ltd., IDBI Tower, 21st Floor, WTC Complex, Cuffe Parade, Mumbai (Maharashtra) - 400005, by post latest by June 21, 2013.
Candidates can also dropped their application form in the specially kept box at the Reception Counter of IDBI Bank Ltd., IDBI Tower, Ground Floor, WTC Complex, Cuffe Parade, Mumbai - 400005, latest by June 21, 2013.
Candidates should mention "Application for the Post of Faculty (Agri Business) on Contract Basis - April 2013" on the envelope in which the form would be sent.
For more information regarding the applying format, candidates can visit the aforementioned IDBI Bank Limited website.
Jobs in IDBI Bank Ltd.


Good evening! I am back tonight with day 10 of the 31 Day Challenge and I am sharing one of my favorite ways to gradient…. with glitter! Glitter gradients are fun to do and create a stunning look without a ton of work.
For my glitter gradient I used Sinful Colors Black on Black for my base color and Dollish Polish Go Luigi! for the glitter goodness. The stars are kinda hard to get out of the bottle which worked perfect for this gradient. I was able to hand place the stars in my desired position and create a finished look.
I looooooove it! Black + turquoise/teal is one of my favorite combos.


Jurjī Zaydān was a Lebanese novelist, journalist, and scholar of the Nahḍa ('awakening'), an intellectual current of the long nineteenth century for the renewal of Arab culture. With his cultural journal al-Hilāl (The Crescent), established in 1892 in Cairo, Zaydān developed a very successful medium to popularise knowledge about Arab history and Arabic literature in order to establish a national consciousness. He became especially famous for his novels on the history of Islam, ranging from the seventh to the beginning of the twentieth century (most of them serialised in al-Hilāl), which are outstanding for their impact both on the history of Arab nationalism and Arabic literature and remain well-read classics to this day.


Was walking along the Chester City Wall and this lady appeared pushing her bike in a most determined way. Converted the image to sepia as I thought it added a little, plus the vignette. Taken in 2008 but I think it has a slightly timeless feel.
This is a gorgeous picture Rod. I love the timeless look of it!
Great pic Rod ... love the sepia look.
Excellent processing, love the atmospheric feeling..


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New ICC prosecutor arrives in Sudan
AFP , Tuesday 10 Aug 2021
The United Nations says 300,000 people were killed and 2.5 million displaced in the conflict in Darfur, which erupted in the vast western region in 2003
File photo: Provided by Organization for the General Coordination of Camps for Displaced and Refugees, smoke rises from Abu Zar camp for displaced persons in West Darfur, Sudan, on Tuesday, April 6, 2021. AP
Darfur peace prerequisites
UN says closing Darfur peacekeeping operation has hiccups
ICC prosecutor urges Sudan to hand over Darfur suspects
The International Criminal Court's chief prosecutor Karim Khan has arrived in Sudan for a week of talks including on outstanding arrest warrants for genocide in Darfur, state media reported Tuesday.
Khan will hold talks on "ways to boost cooperation" on investigations into the crimes committed during the devastating civil war in Darfur, the official SUNA news agency said.
The United Nations says 300,000 people were killed and 2.5 million displaced in the conflict, which erupted in the vast western region in 2003.
Last week, Sudan's cabinet voted to ratify the Rome Statute of the ICC, a move seen as a step towards ousted president Omar al-Bashir potentially facing trial for genocide.
Bashir, who ruled Sudan with an iron fist for three decades, was deposed in April 2019 following months of protests.
The ICC said that Khan, a British lawyer who replaced Fatou Bensouda as prosecutor of The Hague-based war crimes court in June, was on a "week-long mission to discuss cooperation with the authorities and other stakeholders".
Since August 2019, Sudan has been led by a transitional civilian-military administration, which vowed to bring justice to victims of crimes committed under Bashir.
Khartoum signed a peace deal last October with key Darfuri rebel groups, with some of their leaders taking top jobs in government, although violence continues to dog the region.
War in Darfur broke out in 2003 when non-Arab rebels took up arms complaining of systematic discrimination by Bashir's Arab-dominated government.
Khartoum responded by unleashing the notorious Janjaweed militia, recruited from among the region's nomadic peoples.
Human rights groups have long accused Bashir and his former aides of using a scorched earth policy, raping, killing, looting and burning villages.
Bashir, who is being held in the high security Kober prison in Khartoum along with former aides also wanted by the ICC, faces charges of genocide, war crimes and crimes against humanity.
The former president was convicted in December 2019 of corruption, and has been on trial in Khartoum since July 2020 for the Islamist-backed 1989 coup which brought him to power.
Last year, alleged senior Janjaweed militia leader Ali Muhammad Ali Abd al-Rahman, also known by the nom de guerre Ali Kushayb, surrendered to the court.
ICC judges said in July he will be the first suspect to be tried over the Darfur conflict, facing 31 counts including murder, rape and torture.
Also In Africa
South Africa's crippling power cuts not sparing the dead: AFP report
Ethiopia's PM Abiy Ahmed in Sudan on first visit since 2020
France recalls ambassador to Burkina Faso, pulls out troops
Witnesses say latest ethnic clashes in Ethiopia kill dozens
French troops to withdraw from Burkina Faso within a month
UN agency warns humanitarian crisis in Horn of Africa expanding, deepening
Nigeria's 2023 presidential election: 10 factors that could affect the outcome
Macron wants Burkina 'clarifications' on call for French troops to leave


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Practical management of patients on apixaban: a consensus guide
Christopher Ward1,
Greg Conner2,
Geoffrey Donnan3,
Alexander Gallus4 &
Simon McRae5
Atrial fibrillation (AF) is a common tachyarrhythmia in Australia, with a prevalence over 10% in older patients. AF is the leading preventable cause of ischaemic stroke, and strokes due to AF have a higher mortality and morbidity. Stroke prevention is therefore a key management strategy for AF patients, in addition to rate and rhythm control. Anticoagulation with warfarin has been an enduring gold standard for stroke prevention in NVAF patients. In Australia, three novel oral anticoagulants (NOACs), apixaban, dabigatran and rivaroxaban are now approved and reimbursed for stroke prevention in patients with non-valvular AF (NVAF). International European Cardiology guidelines now recommend either a NOAC or warfarin for NVAF patients with a CHA2DS2-VASc score ≥2, unless contraindicated. Apixaban is a direct factor Xa inhibitor with a 12-hour half-life and 25% renal excretion that was found in a large trial of NVAF patients to be superior to warfarin in preventing stroke or systemic embolism. In this trial population, apixaban also resulted in less bleeding and a lower mortality rate than warfarin.
Clinical experience with apixaban outside of clinical trials has been limited, and there is currently little evidence to guide the management of bleeding or invasive procedures in patients taking apixaban. The relevant currently available animal and ex vivo human data were collected, analyzed and summarized.
This multi-disciplinary consensus statement has been written to serve as a guide for healthcare practitioners prescribing apixaban in Australia, with a focus on acute and emergency management.
The predictable pharmacokinetics and minimal drug interactions of apixaban should allow for safe anticoagulation in the majority of patients, including temporary interruption for elective procedures. In the absence of published data, patients actively bleeding on apixaban should receive standard supportive treatment. Quantitative assays of apixaban level such as chromogenic anti-Xa assays are becoming available but their utility is unproven in this setting. Specific antidotes for novel anticoagulants, including apixaban, are in clinical development.
In Australia, three novel oral anticoagulants (NOACs) have been approved for the prevention of stroke in patients with non-valvular atrial fibrillation (NVAF) and one or more additional risk factors for stroke (prior stroke, prior transient ischaemic attack, prior systemic embolism, age ≥75 [or age ≥65 years associated with one of the following: diabetes mellitus, coronary artery disease, or hypertension], arterial hypertension requiring treatment, diabetes mellitus, heart failure ≥ New York Heart Association Class 2, decreased left ventricular ejection fraction or documented peripheral arterial disease). These are dabigatran, a direct thrombin inhibitor, and two direct factor Xa inhibitors, apixaban and rivaroxaban. All three are also approved in Australia for the prevention of venous thromboembolic events (VTE) in adult patients who have undergone major orthopaedic surgery of the lower limb. Rivaroxaban is approved for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) and the prevention of recurrent venous thromboembolism. These novel oral anticoagulants have short half-lives (dabigatran 12-17 hrs, apixaban ~12 hrs, rivaroxaban 5-13 hrs), predictable pharmacokinetics and few drug-drug and drug-food interactions, compared to warfarin. In addition to their favourable pharmacokinetic profiles, dabigatran 110 mg and rivaroxaban have demonstrated similar rates of stroke and systemic embolism reduction to warfarin in NVAF patients, with dabigatran 150 mg and apixaban demonstrating a superior reduction in stroke and systemic embolism, compared to warfarin [1–3]. Additionally, dabigatran 110 mg and apixaban resulted in significantly less major bleeding, compared to warfarin [1, 3]. Although specific antidotes for these agents are currently in development, the lack of a reversal strategy has raised concern among healthcare providers.
In the absence of robust clinical data for emergency and peri-operative management of patients receiving apixaban, an expert panel of Australian clinicians from the fields of cardiology, neurology and haematology convened to develop this practical consensus guide for apixaban management in Australia, utilising the currently available animal and ex vivo human data.
About apixaban
Apixaban is a direct FXa inhibitor with rapid onset of action, a 12-hour half-life and only ~25% renal excretion [4, 5]. Apixaban is indicated in Australia for the prevention of venous thromboembolic events (VTE) in adult patients who have undergone elective total hip or total knee replacement surgery and for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and at least one additional risk factor for stroke. The recommended dose of apixaban for VTE prophylaxis is 2.5 mg BID. The recommended dose of apixaban for stroke prevention in non-valvular atrial fibrillation (NVAF) is 5 mg BID (2.5 mg BID if ≥2 of the following; ≤60 kg, ≥80 years, serum creatinine level ≥133 μm/L) [5].
The risk of stroke and bleeding must be assessed for each patient before commencing any anticoagulation therapy, including apixaban. Some of the patients excluded from the trials [3, 6] had baseline characteristics that were associated with increased risk of bleeding (e.g. recent major bleeding, renal insufficiency [CrCl <25 ml/min], severe hepatic impairment, platelet count <100), and there are no or insufficient data on the use of apixaban in such patients. The clinical trials excluded aspirin doses >165 mg/day or dual anti-platelet therapy [3, 6]. The concomitant use of apixaban with anti-platelet agents increases the risk of bleeding [7]. Apixaban should be used with caution when co-administered with NSAIDs (including acetylsalicylic acid) because these medicinal products typically increase the bleeding risk. A significant increase in bleeding risk was reported with the triple combination of apixaban, acetylsalicylic acid and clopidogrel in a clinical study in patients with acute coronary syndrome [8].
Laboratory measurement of apixaban
At present, there is no validated coagulation assay to measure apixaban effect. As a result of FXa inhibition, apixaban prolongs standard clotting tests such as prothrombin time (PT), activated partial thromboplastin time (aPTT) but with variability between reagents [9]. Increases in clotting times are small at best, and the PT may remain normal (ratio <1.2) at a therapeutic concentration of apixaban [9]. Therefore the PT and APTT are not recommended to assess the pharmacodynamic effects of apixaban [5].
Specialised clotting assays can be used to measure apixaban effects. Anti-FXa activity exhibits a close direct linear relationship with apixaban plasma concentration, reaching maximum values at the time of apixaban peak plasma concentrations. The relationship between apixaban plasma concentration and anti-FXa activity is linear over a wide dose range of apixaban [10]. Although treatment with apixaban at the recommended dose does not require routine laboratory monitoring, measurement of drug level by a chromogenic anti-FXa assay may be useful in exceptional situations where knowledge of the apixaban level may help to inform clinical decisions, e.g. overdose or emergency surgery [5]. Anti-Xa assays are generally available in large Australian teaching hospitals, but may not be routinely performed in smaller institutions or after hours. These assays may also be difficult to access in other countries, with significant delays in reporting. Diagnostic laboratories will need validated, commercial apixaban controls and calibrators to adapt their anti-Xa assays for apixaban. Although commercial research-use only apixaban-specific calibrators are currently available in Australia, a standard curve constructed with commercial LMWH standards was reported to show an equally strong correlation with apixaban plasma concentration (r2 = 0.89) as one constructed with apixaban (r2 = 0.88) [11]. A dilute prothrombin time (dPT), achieved by diluting the thromboplastin reagent in 100 mmol/L CaCl2, has been proposed as an improved assay for factor Xa inhibitors [12]. This modification prolonged the PT measurements at therapeutic concentrations of apixaban and showed greater sensitivity than a standard PT [12]. However, others have found that dPT was no better than PT in terms of sensitivity [9], suggesting that further development of these assays is needed.
The delay between the last intake of the drug and the blood sampling should be considered when assessing apixaban levels, since assays are influenced proportionally to apixaban concentration [9].
Interactions with other medications
Apixaban is metabolized mainly by CYP3A4/5 and is a substrate of efflux transport proteins P-glycoprotein (P-gp) and Breast Cancer Resistance Protein [5]. Therefore, apixaban is contraindicated in patients who are receiving concomitant treatment with strong inhibitors of both CYP3A4 and P-gp, such as azole-antimycotics or HIV protease inhibitors [5] e.g. ketoconazole, itraconazole, voriconazole, posaconazole or ritonavir.
No dose adjustment for apixaban is required when this is co-administered with less potent inhibitors of CYP3A4 and/or P-gp [5] such as diltiazem, naproxen, amiodarone, verapamil, clarithromycin or quinidine.
The concomitant use of apixaban with strong CYP3A4 and P-gp inducers may lead to reduced apixaban plasma concentrations. No dose adjustment for apixaban is required during concomitant therapy with such agents, however strong inducers of both CYP3A4 and P-gp should be co-administered with caution [5] e.g. rifampicin, phenytoin, carbamazepine, phenobarbital and St John's Wort.
Famotidine, a typical gastric acid suppressant, does not affect the pharmacokinetics of apixaban [13]. As such, increases in gastric pH due to other gastric acid modifiers (such as other H2-receptor antagonists, proton pump inhibitors, and antacids) or the presence of abnormally elevated gastric pH (e.g. achlorhydria) are unlikely to affect the pharmacokinetics of apixaban [13].
Starting apixaban
Prior to initiating apixaban, liver function and renal function testing should be performed. The European Society of Haematology 2012 guidelines recommend assessment of renal function (by calculated CrCl) be mandatory for all NOACs, with renal function being assessed annually in patients with normal (CrCl ≥80 mL/min) or mild (CrCl 50–79 mL/min) renal impairment, and 2–3 times per year in patients with moderate (i.e. creatinine clearance 30–49 mL/min) renal impairment [14].
Patients with impaired renal function (≤80 mL/min) were at higher risk for all cardiovascular events during the ARISTOTLE trial, and the incidence of major bleeding increased significantly with increasing renal dysfunction [15]. Apixaban was associated with less major bleeding compared with warfarin for three methods of glomerular filtration rate estimation (Cockcroft–Gault, Chronic Kidney Disease Epidemiology Collaboration and cystatin C) and stroke or systemic embolism occurred less frequently in patients assigned to apixaban than warfarin, regardless of renal function [15].
Switching from warfarin to apixaban
When switching anticoagulation from warfarin to apixaban, it is important to avoid using both drugs at therapeutic doses simultaneously; it is recommended that the INR is monitored daily after the cessation of warfarin, and that apixaban is not started until the INR is <2.0, typically approximately three days after cessation of therapeutic warfarin [3].
Switching from low molecular weight heparin (LMWH) to apixaban
As both agents have a similar rapid onset of FXa inhibition and effective half-life, switching anticoagulation from LMWH (e.g. enoxaparin) to apixaban, (and vice versa), can simply be done at the time of the next scheduled dose [5].
Switching from apixaban
An increased risk of stroke was observed during the transition from apixaban to warfarin in clinical trials in patients with non-valvular atrial fibrillation [16]. Discontinuation of apixaban prior to the onset of an effective antithrombotic effect of VKA could result in an increased risk of thrombosis. If anticoagulation with apixaban must be discontinued for any reason other than pathological bleeding, consider coverage with another anticoagulant.
Apixaban to warfarin
When converting from apixaban to warfarin, continue apixaban for 48 hours after the first dose of warfarin. After 2 days of co-administration of apixaban with warfarin, obtain an INR prior to the next scheduled dose of apixaban. Continue co-administration of apixaban and warfarin until the INR is ≥ 2.0.
Apixaban to low molecular weight heparin (LMWH)
As both agents have a similar rapid onset of FXa inhibition and effective half-life, switching anticoagulation from apixaban to LMWH (e.g. enoxaparin) and vice versa, can simply be done at the time of the next scheduled dose [5].
Bleeding management in patients receiving apixaban
In the ARISTOTLE study of apixaban in patients with atrial fibrillation, annual major bleeding events for apixaban compared to warfarin were 2.13% per year versus 3.09% per year (p < 0.001) [3]. Intracranial haemorrhage events were 0.33% per year for apixaban, compared to 0.80% per year for warfarin (p < 0.001) [3].
Spontaneous bleeding may occur with any anticoagulant. In the absence of published data regarding the treatment of patients with active bleeding while receiving apixaban, the following advice for general management of bleeding events is based on expert consensus (Figure 1).
Considerations for the management of bleeding, based on expert consensus.
Establish the primary source of bleeding wherever possible, and secure haemostasis with local measures.
Most cases of minor bleeding will resolve after cessation of drug, standard supportive treatment, including transfusion, mechanical compression and other local measures.
If bleeding occurs within 6 hours of last apixaban dose, activated charcoal may reduce apixaban absorption, and hence anticoagulant effect [17]. This should also be considered soon after overdose or accidental ingestion.
A specific antidote for apixaban is not currently available [5]. Two synthetic molecules are currently in early clinical trials for apixaban reversal. Andexanet alpha (PRT064445) is a truncated form of enzymatically inactive factor Xa, which can dose-dependently reverse the inhibitory activity and correct the prolongation of ex vivo clotting times by apixaban and other factor Xa inhibitors [18]. Another synthetic small molecule, aripazine (PER977), appears to have broad activity against the NOACs, reversing the anticoagulant activity of dabigatran, rivaroxaban, apixaban and edoxaban in rat bleeding models [19].
Apixaban is highly (~87%) protein bound, and hence not expected to be dialyzable [5]. Based on studies of other factor Xa inhibitors in healthy volunteers, prothrombin complex concentrates (PCC) may reverse the anticoagulant effect, however the effect of PCC on clinical bleeding is not proven [20]. When apixaban (200 ng/ml) was added in vitro to blood from healthy donors, PCC and activated PCC were more effective at improving thrombin generation than recombinant FVIIa (rFVIIa) [21].
There is no clinical evidence examining the use of rFVIIa or bypassing agents (FEIBA) in bleeding patients receiving apixaban. In a rabbit model of apixaban-induced bleeding, neither rFVIIa nor PCC reduced blood loss from a standardised hepatosplenic injury, although rFVIIa did reverse prolongation of the prothrombin time and shortened skin bleeding time [22]. When apixaban (200 ng/ml) was added in vitro to blood from healthy donors, rFVIIa was more effective than PCC in restoring clotting times and thromboelastography parameters [21]. In animal, in vitro and healthy volunteer studies, these agents have partially reversed the anticoagulant effect of apixaban and other factor Xa inhibitors [23–26]. These agents can be considered for life-threatening bleeding, but carry a proven risk of thrombosis.
There is no evidence to support the use of FFP, other than for volume replacement in case of major bleeding.
Peri-operative management in patients receiving apixaban
In stable patients, apixaban has a predictable half-life of 8-12 hours, which leaves residual activity of up to 50% at 12 hours and less than 25% at 24-hours after drug cessation [4]. This means that apixaban can be ceased for a shorter period of time than warfarin before invasive procedures, without the routine need to bridge with alternative anticoagulants such as heparin.
Planning for elective surgery or invasive procedures should involve balancing the intervention-associated bleeding risk and thrombotic risk associated with anticoagulant interruption in each individual. A "safe" residual drug level of apixaban for surgery is presently unknown, and no test has been correlated with bleeding risk. As such, there is currently no known threshold at which apixaban patients' bleeding risk are able to be comparable to non-apixaban treated patients [27].
In general, apixaban should be discontinued 2 to 3 days prior to elective surgery or invasive procedures [5], as outlined below and in Figure 2. There are small groups of people at higher risk of thrombosis (e.g. CHADS2 > 5, recent TIA or stroke) where an individualised approach is needed to minimise the period of sub-therapeutic anticoagulation. A recent review of periprocedural use of antithrombotic therapy notes the importance of checking creatinine clearance in patients on rivaroxaban and apixaban, prior to cessation for high-risk procedures [28]. A longer period of pre-operative discontinuation, up to 5 days, can be considered for patients with renal or hepatic impairment or other conditions associated with decreased drug elimination. In this setting, "bridging" with LMWH has been proposed for patients with a high risk of thrombosis [27]. Given the predictable pharmacokinetics of apixaban, bridging with an alternative anticoagulant should not be required in the majority of cases.
Perioperative dosing/elimination.
Advice for assessing peri-procedural dosing
High bleeding risk
Procedures with a high risk of bleeding (e.g. neurosurgical, urological procedures, major abdominal or orthopaedic): aim to achieve no residual apixaban effect at the time of the procedure; last dose of drug should be 3 days prior (5 missed doses including morning of surgery – Figure 2) [29].
Low bleeding risk
Procedures with a low risk of bleeding (e.g. inguinal hernia repair, percutaneous biopsy, dental extractions): aim to achieve minimal-mild residual apixaban effect at the time of the procedure; last dose of drug should be 2 days prior (3 missed doses including morning of surgery – Figure 2) [29].
Minimal bleeding risk
For selected procedures with minimal risk of bleeding (e.g. cataract surgery, skin cancer excision): therapeutic anticoagulation may be continued.
Re-commencing apixaban after surgery
Re-commence apixaban dosing only once surgical haemostasis has been secured (typically 24 hours after surgery) [29]. In general, caution should be exercised with re-instituting therapeutic anticoagulation within the first 48 hours after surgery. Where there is a risk of post-operative venous thrombosis and the bleeding risk is high, consider a reduced dose of 2.5 mg BID (recommended prophylactic dose) for the immediate post-operative period.
In patients with poor oral absorption or nil by mouth after surgery, parenteral anticoagulants may be needed until reliable oral absorption is established.
Neuraxial anaesthesia
Indwelling epidural or intrathecal catheters must be removed at least 5 hours prior to the first dose of apixaban. Experience with neuraxial blockade is limited and extreme caution is therefore recommended when using apixaban in this setting (see P.I.) [5].
Apixaban is a direct FXa inhibitor indicated in Australia for the prevention of venous thromboembolic events (VTE) in adult patients who have undergone elective total hip or total knee replacement surgery (2.5 mg BID) and for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and at least one additional risk factor for stroke (5 mg BID or 2.5 mg BID if ≥2 of the following; ≤60 kg, ≥80 years, serum creatinine level ≥133 um/L) [5].
In the ARISTOTLE study of apixaban in patients with atrial fibrillation, annual major bleeding events for apixaban compared to warfarin were 2.13% per year versus 3.09% per year (p < 0.001). Intracranial haemorrhage events were 0.33% per year for apixaban, compared to 0.80% per year for warfarin (p < 0.001) [3].
There is no standardised assay currently commercially available in Australia to measure apixaban effect. As apixaban minimally prolongs PT or aPTT, these clotting tests are not recommended to assess the pharmacodynamic effects of apixaban [5]. A chromogenic anti Xa assay or dilute PT assay may be useful, where knowledge of apixaban exposure is required [10–12].
Apixaban is contraindicated in patients who are receiving concomitant treatment with strong inhibitors of both CYP3A4 and P-gp, however no dose adjustment for apixaban is required when co-administered with less potent inhibitors. No dose adjustment for apixaban is required during concomitant therapy with strong CYP3A4 and P-gp inducers, however they may lead to reduced apixaban plasma concentrations [5].
A specific antidote for apixaban is not currently available, however specific anti-Xa inhibitor and universal novel oral anticoagulant antidotes are in clinical development [18, 19].
In the absence of published data regarding the treatment of patients with active bleeding while receiving apixaban, discontinue apixaban, apply standard supportive treatment and other local measures [5]. Activated charcoal may reduce apixaban absorption within 6 h of last dose [17].
Apixaban is not expected to be dialyzable, however prothrombin complex concentrates (PCC) may reverse the anticoagulant effect and recombinant FVIIa or bypassing agents (FEIBA) can be considered for life-threatening bleeding. FFP will not reverse apixaban effect but can be used as volume replacement in case of major bleeding.
Planning for elective surgery or invasive procedures should involve balancing the intervention-associated bleeding risk and thrombotic risk associated with anticoagulant interruption in each individual.
APTT:
Activated partial thromboplastin time
ASA:
DVT:
FEIBA:
Factor VIII inhibitor bypassing agent
FX:
Novel oral anticoagulants
Non-steroidal antiflammatory drugs
NVAF:
Non-valvular atrial fibrillation
PCC:
Prothrombin complex concentrates
Pulmonary embolus
Prothrombin time
rFVIIa:
Recombinant activated Factor VII
VTE:
Venous thromboembolism.
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L, the RE-LY Steering Committee and Investigators: Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009, 361: 1139-5. 10.1056/NEJMoa0905561
Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, Breithardt G, Halperin JL, Hankey GJ, Piccini JP, Becker RC, Nessel CC, Paolini JF, Berkowitz SD, Fox KA, Califf RM, and the ROCKET AF Steering Committee, for the ROCKET AF Investigator: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011, 365: 883-891. 10.1056/NEJMoa1009638
Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, et al.: ARISTOTLE Committees and Investigators: apixaban versus warfarin in patients with atrial fibrillation. New Engl J Med 2011, 365: 981-992. 10.1056/NEJMoa1107039
Frost C, Nepal S, Wang J, Schuster A, Barrett YC, Mosqueda-Garcia R, Reeves RA, Lacreta F: Apixaban, an oral, direct factor Xa inhibitor: single-dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects. Br J Clin Pharmacol 2013, 75(2):476-487. 10.1111/j.1365-2125.2012.04369.x
ELIQUIS® (Apixaban) Approved Product Information. Bristol-Myers Squibb Australia Pty Ltd and Pfizer Pty Ltd; 2013. http://www.bmsa.com.au/products/pages/Home.aspx
Connolly SJ, Eikelboom J, Joyner C, Diener H-C, Hart R, Golitsyn S, Flaker G, Avezum A, Hohnloser SH, Diaz R, Talajic M, Zhu J, Pais P, Budaj A, Parkhomenko A, Jansky P, Commerford P, Tan RS, Sim K-H, Lewis BS, Van Mieghem W, Lip GYH, Kim JH, Lanas-Zanetti F, Gonzalez-Hermosillo A, Dans AL, Munawar M, O'Donnell M, Lawrence J, Lewis G, et al.: Apixaban in patients with atrial fibrillation. N Engl J Med 2011, 364: 806-817. 10.1056/NEJMoa1007432
Alexander JH, Lopes RD, James S, Kilaru R, He Y, Mohan P, Bhatt DL, Goodman S, Verheugt FW, Flather M, Huber K, Liaw D, Husted SE, Lopez-Sendon J, De Caterina R, Jansky P, Darius H, Vinereanu D, Cornel JH, Cools F, Atar D, Leiva-Pons JL, Keltai M, Ogawa H, Pais P, Parkhomenko A, Ruzyllo W, Diaz R, White H, Ruda M, et al.: Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med 2011, 365: 699-708. 10.1056/NEJMoa1105819
Alexander JH, Becker RC, Bhatt DL, Cools F, Crea F, Dellborg M, Fox KA, Goodman SG, Harrington RA, Huber K, Husted S, Lewis BS, Lopez-Sendon J, Mohan P, Montalescot G, Ruda M, Ruzyllo W, Verheugt F, Wallentin L, APPRAISE Steering Committee and Investigators: Apixaban, an oral, direct, selective Factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome. Circulation 2009, 119: 2877-2885.
Douxfils J, Chatelain C, Chatelain B, Dogné J-M, Mullier F: Impact of apixaban on routine and specific coagulation assays: a practical laboratory guide. Thromb Haemost 2013, 110(2):283-294. 10.1160/TH12-12-0898
Becker RC, Yang H, Barrett Y, Mohan P, Wang J, Wallentin LC, Alexander JH: Chromogenic laboratory assays to measure the factor Xa-inhibiting properties of apixaban—an oral, direct and selective factor Xa inhibitor. J Thromb Thrombolysis 2011, 32: 183-187. 10.1007/s11239-011-0591-8
Barrett YC, Wang Z, Frost C, Shenker A: Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay. Thromb Haemost 2010, 104: 1263-1271. 10.1160/TH10-05-0328
Barrett YC, Wang Z, Knabb RM: A novel prothrombin time assay for assessing the anticoagulant activity of oral factor Xa inhibitors. Clin Appl Thromb Hemost 2012, 19(5):522-528.
Upreti VV, Song Y, Wang J, Byon W, Boyd RA, Pursley JM, Lacreta F, Frost CE: Effect of famotidine on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor. Clin Pharmacol: Advances and Applications 2013, 5: 59-66.
Camm AJ, Lip GY, Caterina R, Savelieva I, Atar D, Hohnloser SH, G H, Kirchhof P, ESC Committee for Practice Guidelines (CPG): 2012 focused update of the ESC Guidelines for the management of atrial fibrillation. Eur Heart J 2012, 33: 2719-2747.
Hohnloser SH, Hijazi Z, Thomas L, Alexander JH, Amerena J, Hanna M, Keltai M, Lanas F, Lopes RD, Lopez-Sendon J, Granger CB, Wallentin L: Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial. Eur Heart J 2012, 33: 2821-2830. 10.1093/eurheartj/ehs274
Granger CB, Alexander JH, Hanna M, Wang J, Mohan P, Lawrence J, Hylek E, Ansell JE, Wallentin L, for the ARISTOTLE investigators: Events after discontinuation of randomized treatment at the end of the ARISTOTLE trial [abstract]. Eur Heart J 2012, 33(Abstract Supplement):685-686.
Wang X, Tirucherai G, Pannacciulli , Wang J, Elsrougy A, Teslenko V, Chang M, Zhang D, Frost C: Effect of activated charcoal on the pharmacokinetics of apixaban in healthy subjects [abstract]. Clinical Pharmacol Ther 2012, 91(Suppl 1):s41.
Lu G, DeGuzman FR, Hollenbach SJ, Karbarz MJ, Abe K, Lee G, Luan P, Hutchaleelaha A, Inagaki M, Conley PB, Phillips DR, Uma S: A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med 2013, 19(4):446-451. 10.1038/nm.3102
Laulicht B, Bakhru S, Lee C, Baker C, Jiang X, Mathiowitz E, Costin J, Steiner S: Small molecule antidote for anticoagulants [abstract]. Circulation 2012, 126: A11395.
Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M: Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011, 124: 1573-1579. 10.1161/CIRCULATIONAHA.111.029017
Escolar G, Arellano-Rodrigo E, Reverter JC, Villalta J, Sanz V, Molina P, Diaz-Ricart M, Galan AM: Reversal of apixaban induced alterations of hemostasis by different coagulation factor concentrates: studies in vitro with circulating human blood [abstract]. Circulation 2012, 126: 520-521.
Martin AC, Le Bonniec B, Fischer AM, Marchand-Leroux C, Gaussem P, Samama CM, Godier A: Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis. Int J Cardiol 2013, 168: 4228-4233. 10.1016/j.ijcard.2013.07.152
Kaatz S, Kouides PA, Garcia DA, Spyropolous AC, Crowther M, Douketis JD, Chan AK, James A, Moll S, ORtel TL, Van Cott EM, Ansell J: Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. Am J Hematol 2012, 87(Suppl 1):S141-S145.
Bauer KA: Reversal of antithrombotic agents. Am J Hematol 2012, 87(Suppl 1):S119-S126.
Fukuda T, Honda Y, Kamisato C, Morishima Y, Shibano T: Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents. Thromb Haemost 2012, 107: 253-259.
Marlu R, Hodaj E, Paris A, Albaladejo P, Cracowski JL, Pernod G: Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. Thromb Haemost 2012, 108: 217-224. 10.1160/TH12-03-0179
Ferrandis R, Castillo J, de Andrés J, Gomar C, Gómez-Luque A, Hidalgo F, Llau JV, Sierra P, Torres LM: The perioperative management of new direct oral anticoagulants: a question without answers. Thromb Haemost 2013, 110: 515-522. 10.1160/TH12-11-0868
Baron TH, Kamath PS, McBane RD: Antithrombotic therapy and invasive procedures. New Engl J Med 2013, 368: 1079-1080.
Douketis JD: Pharmacologic properties of the new oral anticoagulants: a clinician-oriented review with a focus on perioperative management. Curr Pharm Des 2010, 16: 3436-3441. 10.2174/138161210793563338
Dr Stephanie Lebret (Pfizer Australia) organized the working group meeting and assisted the authors in the preparation of this manuscript.
Kolling Institute, University of Sydney; Royal North Shore Hospital, Sydney, NSW, Australia
Cardiovascular Diagnostic Services, Liverpool, NSW, Australia
Greg Conner
Florey Institute of Neuroscience and Mental Health, The Austin Hospital, Heidelberg, VIC, Australia
Geoffrey Donnan
Flinders Medical Center, Bedford Park, SA, Australia
Alexander Gallus
Queen Elizabeth Hospital; Royal Adelaide Hospital, Woodville South, SA, Australia
Simon McRae
Correspondence to Christopher Ward.
The authors received honoraria and travel support from Pfizer Australia to review the literature and attend a working group meeting where this consensus statement was generated.
CW contributed to consensus statement and wrote the manuscript; GD contributed to consensus statement and reviewed the manuscript; ASG contributed to consensus statement and reviewed the manuscript; GC contributed to consensus statement and reviewed the manuscript; SM contributed to consensus statement and reviewed the manuscript. All authors read and approved the final manuscript.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Ward, C., Conner, G., Donnan, G. et al. Practical management of patients on apixaban: a consensus guide. Thrombosis J 11, 27 (2013). https://doi.org/10.1186/1477-9560-11-27
DOI: https://doi.org/10.1186/1477-9560-11-27
Perioperative management


text:
"Ride Along 2" About As Much Fun As A Parking Ticket
Tim Story's "Ride Along" was garden-variety fluff, a copy of a copy that saw buddy-cop progenitor "Beverly Hills Cop" filtered through any one of its endless imitators ("Rush Hour," "Blue Streak," and so on). It follows, then, that "Ride Along 2" is a copy of a copy of a copy, a veritable flow chart of the devolution of the genre.
Its only noteworthy scene is its last, one that comes with a startling epiphany: two films in and we know next to nothing about the series' lead character.
The broad strokes are there, of course. Atlanta cop James Payton (Ice Cube) is a devoted cop, over-protective of his sister Angela (Tika Sumpter), and doesn't much like his future brother-in-law and now fellow cop Ben Barber (Kevin Hart).
But when the movie inevitably ends with wedding scene and James raising his glass in a toast, we're left wondering, "Who is this person?"
Ben comes with a modicum of depth – he immaturely favors video games over time with Angela and has an aptitude for moments of accidental genius – but James is a blank space. He seems to have no life beyond what's onscreen and his rapport with Miami cop and token romantic interest Maya (Olivia Munn) comes off as utterly inhuman, like an E.T. newly marooned on Earth.
Tim Story and his screenwriters have only exacerbated the problems of their first film, beginning with a straight-faced cop movie intro that withholds any attempt at humor for the better part of ten minutes. We're introduced to a boring politician-turned-kingpin in Antonio Pope (Benjaming Bratt) and his reluctant tech guy A.J. (Ken Jeong) in a sequence that seems twice as long as it is, and then we're off to an extended nod to the "Fast And Furious" series (complete with Tyrese Gibson) that does little but fill time.
The rest of the picture is mush of sloppy direction and editing – as would be expected from a Tim Story project – hinging on its actors to tie the forgettable story together.
Hart had some solid one-liners to work with the last time out, but there are no such jokes here. Just wheezing ad-libs that lead to lots of dead air where scripted laughs might have been and Hart embracing his most annoying tendencies.
Ice Cube brings with him an inherently compelling screen presence, but the aforementioned limitations of his character undermine his attempts at chemistry with Hart. The two never quite spark. Moreover, the role of straight man sells short Cube's considerable comedic talents (see: "22 Jump Street").
"Ride Along 2" isn't a case of diminishing returns; it's a case of no returns, a movie that has no real artistic purpose and a cast and crew that knows it. With a story not even big enough to fill a Post-It note and a noticeable laugh deficit, all but Kevin Hart completists need not apply.
Rating: ★ 1/2 out of ★★★★★ (Bad)
Studio: Universal Pictures
Director: Tim Story
Screenwriters: Phil Hay, Matt Manfredi
Starring: Ice Cube, Kevin Hart, Ken Jeong, Benjamin Bratt, Olivia Munn, Bruce McGill, Tika Sumpter, Sherri Shepherd
MPAA Rating: PG-13 (for sequences of violence, sexual content, language and some drug material)


It comes equipped with all the standard amenities for your driving enjoyment. Chrysler prioritized comfort and style by including: an automatic dimming rear-view mirror, blind spot sensor, and the power moon roof opens up the cabin to the natural environment. It features an automatic transmission, all-wheel drive, and a refined 6 cylinder engine.


text:
S acrosanct
Rules Joining The City Database Groups
North East West South
OOC Html Testing Advertising Affiliates Staff
OOC Name
Sacrosanct contains four distinct neighborhoods, each with their own specific kind of houses and residents. Explore our districts, view lists of our citizens and enjoy our block parties!
What You'll Find Here
Anacosta Heights
Hawethorn Village
River Dale
Situated above the daily life of the city, Anacosta Heights is a tucked away suburb featuring extravagant neo-gothic inspired mansions. The inhabitants of this neighborhood often show their overwhelming wealth with sports cars lining their long, circular driveways, large pools, and manicured gardens. The homeowners of Anacosta Heights treasure their privacy as seen by the high iron gates to the security personnel present at every entrance.
Amelia Marek
Andras Stein
Boone Kendrick
Damon Marcello
Dareios Auerbach
Dorian Ellington-Aragona
Isolt Griffin
Kohl Jones
Sebastian Ellington-Aragona
William Holloway
Dupont Circle is a small suburban neighborhood settled within the serene portion of the southern portion of town. These four-bedroom, single-family homes feature back yards, porches, garages, and far more breathing space then the Village offers. This neighborhood often is more family orientated and even has organized events for children and the neighborhood as a whole.
Abigail Hughes
Gia Jones
Raylin Chike
Settled in the middle of downtown, Hawthorn Village consists of several victorian inspired row houses just off the main street. Due to it's convenience to just about everything, the village can be a tad expensive to live within. However, the residents of this neighborhood often have two to three-story townhouses, often with a one to two-car garage. Many of the houses feature bay windows and/or rooftop terraces with a small fenced-in 'yard'.
Anastasia Romanova
Miyako Aiken
Serafina Dubois
River Dale primarily consists of apartments that, despite their age and industrial appearing interior, still hold to the Victorian history that permeates the town. These apartments are often the cheapest option and sport scuffed, older wooden floors, open floor plans, visible beams, and the occasional brick wall.
Alekai Evero
Alistair Rosenthal
Audette Rousseau
Carolina Bedford
Emerson Navarro
Harper Thomson
Samantha Cassidy
Sterling Tenembrage
everything reminds me of you
Posted on April 01, 2020 by STERLING
I know some things should just stay broken
i'm well aware this should remain unspoken
Sterling's lips pressed together into a hard light at the very sight of his ex-boyfriend. Henry was the very last person he expected to see on the other side of his door this late at night. He had made it clear, their last evening together, how tired he was at Henry's tendency to stray again and again. This time was supposed to be different - the pair purposefully taking it slow if only to work upon the cornerstones of their relationship rather then getting lost in the sex...and look where that had gotten Sterling. The striking blue of his irises narrowed as Henry's gaze slowly turned upwards, tracing the plains of Sterling's bare chest. The warlock was altogether aware of the weight of his ex's eyes upon him. Once upon a time, he had yearned for nothing more than all of Henry's attention. Once he had diligently strived to be the cause of Henry's pants fitting so poorly. Now, the lingering of Henry's eyes upon his waistline prompted nothing but silence and the rise of a singular brow. That explanation on why the man had come to his door, however, was met with almost icy indifference, the Warlock stepping back to let Henry into the comfortable warmth of his flat.
He closed the door firmly behind his boyfriend, only to head purposefully down the hall and the very bathroom that Sterling had only just emerged from. A vague gesture was given towards the room in question as he passed it for the linen closet just past the bathroom. His brows furrowed as he reached into the depths of the closet, pulling out a fresh new towel. The sound of the shower filled his ears, Henry apparently wasting no time. He glanced over towards the door of the bathroom, noting the silhouette of his ex waiting for him. Wordlessly, Sterling handed Henry the plush towel within his hands, that silence between the two persisting several minutes before, abruptly, the Were insisted he'd be out in fifteen minutes flat. His insistence that he'd lock the door on the way out, however, was met with a shrug from Sterling's shoulders. "Sure." The warlock responded simply, his very shortness with his ex certainly displaying those feelings of hurt and anger and frustration that still filled him even in spite of their time apart.
He turned away from the bathroom, Henry firmly closing the bathroom door behind him. Sterling continued towards the end of the hallway, pausing only at the entrance to his own bedroom. Hesitantly, the boy turned, eying the bathroom door in silent contemplation. How Henry's words remained nestled in the depths of his mind as he tried to discern his feelings for the man's loss. Once, he had so eagerly taken in the lost man with no memory, before that still Sterling had attempted to put back together the pieces of a drug-laden broken soul. How many times now, had he taken Henry in when he had nothing? Even before he'd fallen to the charms and charism of the fellow. Was he really going to let his anger for Henry's actions change who he was? Ugh, he would never hear the end of this from Harley, even Fiducia was likely to regard him with ruffled feathers and yet, the idea of tossing Henry out on the streets with nothing but a tent just...ugh.
Sterling sighed audibly, his hand reaching up to run through his brunette locks at his own internal frustration. He turned back towards the linen closet, pulling out Henry's sheets only to take them back into the now-empty bedroom. It took him a bit to fit the bottom sheet to the mattress, the top one neatly laid down only for Sterling to retrieve and unfold a plush blue comforter to lay on the top. He had only just retreated to the closet with a pillow in hand to fetch a pillowcase when the water in the bathroom suddenly cut off. The bright blue of his gaze fluttered towards the bedroom door, the warlock pausing ever so slightly before astutely returning to the task at hand. A look of discontent remained present all the while upon his features as he wrestled the pillow into its case. He was hardly prepared for the quickness at which Henry stepped into the hall, the man nearly running into Sterling in the process. Sterling stepped back out of the way, clearly desiring some...distance from his ex before he tossed him the now covered pillow within his hands towards Henry, the second empty pillowcase still dangling from Sterling's fingertips. "You can sleep in there but tomorrow go get your license and when it arrives, get out." He informed Henry firmly. He'd suffer through Henry's presence, for now, if only so the guilt for turning him out on the street didn't eat Sterling alive.
I'm on the ledge while you're so
God damn polite and composed
I need somebody to heal - By Henry Tudor on April 02, 2020 at 9:43 PM
so many things I shouldn't have missed - By STERLING on April 11, 2020 at 2:46 PM
somebody to know - By Henry Tudor on April 15, 2020 at 3:02 AM
the more that I push and the more you resist - By STERLING on April 22, 2020 at 10:11 PM
somebody to have - By Henry Tudor on April 24, 2020 at 6:37 AM
it's easy to see its for the best - By STERLING on May 13, 2020 at 10:53 PM
somebody to hold - By Henry Tudor on August 26, 2020 at 5:11 PM
when you want more while you leave me with less - By STERLING on September 04, 2020 at 12:37 AM
it's easy to say, but it's never the same - By Henry Tudor on January 13, 2021 at 6:25 AM
Open Posts


Donnie Tinsley is the owner and founder of Tinsley Family Martial Arts. He is Gracie Jiu-jitsu black belt under 8th Degree Red/White belt Master Luiz Palhares. He has dedicated his life to teaching martial arts in the Albemarle Area. Click here for a complete list of instructor credentials, awards, and accomplishments.
Amy Tinsley is the owner and senior instructor at the Tinsley Family Martial Arts Hertford location. Mrs. Amy holds the rank of 3rd Dan Taekwondo (Kukkiwon) and also Senior Instructor in Muay Thai. She is a National Champion and currently teaches Dance and Youth Muay Thai in Hertford, NC.
Morgan Lilly is currently a 3rd Dan Taekwondo Black Belt (Kukkiwon) and the Elizabeth City location's Program Director for Taekwondo. She is an established black belt with many years experience, multiple time AAU State Champion, Regional Champion, and National Level Competitor.


Christina under the stern of the Um El Faroud.
This is one of my favourite parts of the ship: it rears up out of the sand. Some day I'll spend the entire dive just sitting at the rudder, enjoying the perspective.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Please attribute Kristaps, the photographer, with a link to kristaps.bsd.lv/photo0017.html.


text:
Review: Caesars Palace
Comparatively calm, versus Caesars as a whole.
Readers' Choice Awards 2018, 2019, 2020
Courtesy Caesars Palace
Powered By: Expedia
Reviewed by Andrea Bennett
How did it strike you on arrival?
The best thing about arriving at the Augustus and Octavius tower rooms is that they have their own entrance, on Flamingo, far away from the crowds of the Strip. You can valet there and go right to registration, as opposed to the Forum and Julius towers (and even the hotel-within-hotel that is Nobu), where you have to come into the chaotic main entrance. It's all light colors and modern lines in Augustus (no centurions taking selfies with margarita swilling tourists here!), and you won't even be close to a casino floor, so it feels very calm. What's the crowd like?
The travelers who are Augustus regulars know exactly what they want from the 4,000-room Roman extravaganza that is Caesars. Each tower is different, and Augustus is one of the newest constructions (and recently renovated). The rooms are spacious, and though the newer Octavius tower is considered to be an upgrade, it actually takes longer to walk to Octavius from the main entrance and the casino. Those who bypass Octavius for Augustus know this. They're generally well-informed frequent visitors to Vegas who either do business here or gamble here frequently. Where it can take a lot of time in other parts of the resort just to locate coffee, there's a Starbucks just off the lobby here and it all feels much better planned. The good stuff: Tell us about your room.
I've stayed in an Augustus Tower Premium King room, which feels far more modern and with cleaner lines than Caesars as a whole. If you want a great view, ask for a room on the south side of Augustus, since those have the best views of the Bellagio Fountains across the street. The rooms are big, over 600 square feet, and are appointed in modern, dark woods and natural shades, with a dark, plush couch and little sitting area. We're craving some deep, restorative sleep. They got us?
The beds are great. High and super soft. How about the little things, like mini bar, or shower goodies. Any of that find its way into your suitcase?
A 2016 upgrade didn't change the rooms all that much, but did add some nice tech touches like lamps that have electrical outlets and USB ports in their bases, so you don't have to look far to plug in your phone. Please tell us the bathroom won't let us down.
I love the bathrooms in Caesars, which go heavy on the marble and feel really luxurious. Caesars seems to understand that it's important to be able to watch TV at all times, so there are flat panel screens that you can see from your jetted tub.Toiletries are branded with the spa (Qua) name, but aren't so remarkable that you'd care to hoard them. Maybe the most important topic of all: Wi-Fi. What's the word?
The Wi-Fi was super fast and included in the price of the resort fee (which is pretty high, at $44 per night). The catch: I could only connect two devices. So if you're using the Wi-Fi for laptop and phone, your traveling companion will have to pay extra. Room service: Worth it?
Room service is all the standard items—big breakfasts, appetizers, salads, and all the expected entrees (salmon, chicken, a grilled NY strip). But Caesars has done something smart and let guests order from its Chinese restaurant Beijing Noodle No. 9 as well as pizzas from Di Fara. So you feel like you're getting takeout delivered right to your door. (Except that with the $10 delivery fee and the 18 percent included tip and taxes, this may be the highest charge attached to any in room dining in Vegas.) Except for the pizza (which is great) and the Chinese food (which is standard but a great idea), I'd consider skipping in-room dining and heading downstairs.Bacchanal Buffet is a short distance from Augustus Tower. Staff: If you could award one a trophy, who gets it, and why?
I wouldn't necessarily award anything to the staff, but I would award something to the employees of the extremely busy Starbucks in the lobby! Anything stand out about other services and features? Whether it's childcare, gyms, spas, even parking—whatever stuck with you.
The pool complexes (multiple, vast) are beautiful and some are family-friendly. Bacchanal Buffet continues to be one of the most mind-blowing buffets in the world (it never ends and serves about 500 dishes at any one time). If you're going to go to the spa, stay in Augustus Tower, which is the closest to Qua Baths & Spa. The additional benefit here is that you won't have to wander through a casino with wet hair and no makeup after you've been relaxing there. Caesars has more restaurants than you can shake a stick at, and if you feel like walking to the other end of the massive complex, you'll get to the Forum Shops, where the retail offerings are vast and there are even more places to dine. It's truly a self-contained city. What was most memorable—or heartbreaking—about your stay?
Caesars is one of the best places to go in Las Vegas if you've seen Vegas a million times and just want to settle in and relax somewhere. If you want all the things close to you that you need (food, retail, gaming, coffee, a pool and a spa) there are few better places to hole up than here. Bottom line: worth it, and why?
The rooms at Caesars are big, but you might find yourself walking long distances to get to the places you need to go. Depending on the events that are in town, room rates fluctuate in Las Vegas, but these rooms can be comparably priced to Wynn. However, they lack the bells and whistles of Wynn rooms. This is really where you want to check in if you like the idea of checking in to a resort that you don't have to leave.
3570 S Las Vegas BlvdLas Vegas, Nevada, 89109United States
https://www.caesars.com/caesars-palace
2020 Readers' Choice Awards: The Top Hotels in Las Vegas
By CNT Editors
15 Best Hotels in Las Vegas
By Andrea Bennett
The Best Hotels in Las Vegas