text:
Epoetyna beta () – hormon peptydowy, rekombinowany analog ludzkiej erytropoetyny, wytwarzany metodą inżynierii genetycznej w komórkach jajnika chomika chińskiego, lek stymulujący różne etapy erytropoezy.

Mechanizm działania biologicznego
Epoetyna beta jest rekombinowanym analogiem ludzkiej erytropoetyny, wytwarzanym metodami inżynierii genetycznej w komórkach jajnika chomika chińskiego. Zbudowana jest z 165 aminokwasów o sekwencji identycznej z naturalną erytropoetyną oraz identyczną z nią glikozylacją. Mechanizm działania epoetyny beta jest identyczny jak erytropoetyny, ponieważ wiąże się z tym samym receptorem. U pacjentów z niewydolnością nerek jej pozytywny wpływ biologiczny jest związany z niedoborem erytropoetyny. Natomiast u pacjentów z chorobą nowotworową problem polega zarówno na niedoborze erytropoetyny, jak i zmniejszonej wrażliwości na endogenną erytropoetynę.

Zastosowanie medyczne
Epoetyna beta znajduje się na wzorcowej liście podstawowych leków Światowej Organizacji Zdrowia () (2019).

Unia Europejska
Wskazania do zastosowania epoetyny beta:
 niedokrwistość objawowa związana z przewlekłą niewydolnością nerek u dorosłych i dzieci
 niedokrwistość objawowa związana z chemioterapią z powodu choroby nowotworowej (z wyjątkiem nowotworów złośliwych pochodzenia szpikowego) u dorosłych
 uzyskanie większej ilości autologicznych erytrocytów u osób przygotowywanych do zabiegu chirurgicznego z zastosowaniem autotransfuzji (zakres stężenia hemoglobiny 100–130 g/l, bez niedoboru żelaza), jeśli nie ma możliwości przechowania wystarczającej ilości krwi własnej i planowy duży zabieg chirurgiczny wymaga znacznej objętości krwi (nie mniej niż 4 jednostki krwi dla kobiet i nie mniej niż 5 jednostek dla mężczyzn).

Jest dopuszczona do obrotu w Polsce (2020).

Stany Zjednoczone
W USA nie została wprowadzona na rynek farmaceutyczny.

Działania niepożądane
Może powodować następujące działania niepożądane u ponad 1% pacjentów: ból głowy, nadciśnienie tętnicze, zakrzepy w żyłach i tętnicach.

Zobacz też
 epoetyna alfa

Przypisy

Doping
Hormony peptydowe
Krwiotworzenie
Leki z listy leków podstawowych Światowej Organizacji Zdrowia


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You are currently browsing the archives for the tag 'grace kelly'.
I have just received the tragic news that another legend has left the planet. Fashion designer Hubert de Givenchy, who opened his eponymous fashion house in 1952, died past Saturday aged 91 as his partner – former haute couture designer – Philippe Venet has announced today. The couple lived in a Renaissance chateau near Paris.
The aristocratic gentleman was known for his sophisticated and ladylike chic in the 1950s and 1960s and famous for having designed much of the personal and professional wardrobe of Audrey Hepburn, as well as clothing for clients such as Jacqueline Bouvier Kennedy and Grace Kelly.
At the age of seventeen, he moved to Paris where he studied at the École des Beaux-Arts. Givenchy's first designs were done for Jacques Fath in 1945. Later he did designs for Robert Piguet and Lucien Lelong (1946) – working alongside the still-unknown Pierre Balmain and Christian Dior, followed by 5 years working for the avantgarde designer Elsa Schiaparelli before he opened his own design house at the Plaine Monceau in Paris in 1952.
Audrey Hepburn wearing Givenchy in 1954 film «Sabrina».
His style was marked by innovation, contrary to the more conservative designs by Dior. At 25, he was the youngest designer of the progressive Paris fashion scene. His first collections were characterized by the use of rather cheap fabrics for financial reasons, but they always piqued curiosity through their design. Audrey Hepburn, later the most prominent proponent of Givenchy's fashion, and Givenchy met in 1953 during the shoot of «Sabrina». He went on to design the famous «little black dress» she wore in «Breakfast at Tiffany's».
In 1961, when Audrey Hepburn got the roll of Holly Golightly, designer Hubert de Givenchy designed the famous black dress which became one of the most iconic clothing items of the 20th century.
He also developed his first perfume collection for her (L'Interdit and Le de Givenchy) and made Audrey Hepburn the face of it. For the very first time a star was the face of a fragrance's advertising campaign and probably the last time that it was done for free, only by friendship.
At that time, Givenchy also met his idol, Cristóbal Balenciaga. Although a renowned designer, Givenchy not only sought inspiration from the lofty settings of haute couture but also in such avant-garde environments as Limbo, the store in Manhattan's East Village. In 1954, Givenchy's prêt-à-porter collection debuted.
The House of Givenchy was split in 1981, with the perfume line going to Veuve Clicquot, while the fashion branch was acquired by LVMH in 1989. As of today, LVMH owns Parfums Givenchy as well.
De Givenchy retired from fashion design in 1995. His successor to head the Givenchy label was John Galliano, followed by a five-year stay from Alexander McQueen and a term from 2001 to 2004 by Julien Macdonald. As we all know, Riccardo Tisci revived the Givenchy brand tremendously from 2005 until 2017. This season, Clare Waight Keller presented her first runway show for Givenchy.
Rest in peace, Hubert de Givenchy and thank you for all those wonderful fashionable moments.
During Paris Fashion Week, I went to some amazing events that I would like to share with you. Let's get started with one that was truly outstanding, something that you don't see every day.
I was invited to the elegant salons of the association France Ameriques in avenue Franklin Roosvelt, where a very special collaboration, PRINCESS GRACE, MORE THAN AN IMAGE, between Pringle of Scotland and Central Saint Martins was presented.
The collection designed by young talents of the renowned college of arts and design in London features pieces in the finest 100% made in Scotland knitwear, inspired by the wardrobe of H.S.H. Princess Grace of Monaco, who had loved the historical British brand very much and had been frequently seen in it.
H.R.H. Carolina of Monaco Princess of Hanover had come all the way from Monaco to attend this intimate event in honour of her late mother. She had also supported the students and had given them access to the palace archives.
In April 2012, the findings were revealed in an exhibition hosted by the Nouveau Musée National de Monaco featuring never before seen material, showcasing Princess Grace's daily wardrobe in the most relaxed and familial situations, particularly knitwear and Pringle of Scotland archive styles.
… under the creative supervision of the famous Professor Louise Wilson O.B.E. (see photo below to the right). Being among the world's most influential fashion educators, her former students include Christopher Kane, Marios Schwab, Mary Katrantzou, Roksanda Ilincic among many others.
And as Marie Claude Beaud, Director of the Nouveau Musée National de Monaco, put it "Grace Kelly has been a princess, an actress…but above all a woman, a mother".
With this in mind, the collection truly manages to highlight the most personal, discreet and daily aspects of the Princess without loosing its historical heritage, it looks modern and desirable.
Pringle of Scotland's ambassadress Tilda Swinton was leading the conversation.
Interesting to know is that the title PRINCESS GRACE: MORE THAN AN IMAGE derives from a quote that the Princess gave to Time Magazine in 1955, whilst still the film actress Grace Kelly, "I don't want to dress up a picture with just my face". This sense of exploring the person behind the image is evident throughout the project. She will stay in everyone's imagination forever.
And this fall, it is official, we will not only dream of an Hermès Kelly bag.Pringle of Scotland's Kelly sweater will be on everyone's shopping list and it will be definitely more accessible. The capsule collection will hit the shelves in Switzerland in September at Jelmoli.
Stay tuned for an upcoming post on the movie "Grace" that will hit the cinemas in the end of the year and enjoy some more impressions of this beautiful event in Paris below.
Princess Caroline of Monaco's daughter Charlotte Casiraghi graces the September 2011 issue of Vogue Paris. Photographed by Mario Testino, the twenty-page editorial features the stunning brunette in the must-have F/W 2011 pieces by the likes of Gucci, Balmain, Isabel Marant, Dior, Chanel, YSL, Versace and more. I have loved the photos so much that I wanted to share them with you. Isn't she beautiful like her late grandmother Grace Kelly?
Recently I was invited by the Swiss private bank Clariden Leu to attend a very special soirée to celebrate the one year renovation of their headquarter on Bahnhofstrasse 32 in Zurich with the amazing exhibition "A World of Pictures" by Elliott Erwitt. The photography legend had been flown in especially for the evening and it was a real honour to meet him.
Clariden Leu's 'Leuenhof' was built in Neo-Gothic style between 1914 and 1915 and its impressive art gallery is the ideal venue for art exhibitions.
Olivier Jaquet, CEO Clariden Leu, gave an introductory speech and Birgit Filzmaier, owner of the gallery "19th & 20th Century Fine Art Photography" (the place to go if you are interested in Elliott Erwitts's work) the laudation.
Elliott Erwitt was born in France of Russian émigré parents in 1928. His formative years were spent in Italy. At the age of 10 he moved with his family to France afterward immigrating to the United States in 1939.
Grace Kelly, New York City 1955.
Distinguished as both a documentary and commercial photographer, Erwitt has taken some of the most memorable photos of the 20th century, including portraits of Marilyn Monroe, Jackie Kennedy and Grace Kelly, as well as astonishing scenes of everyday life, filled with poetry, wit and a special sense of humor. Famous for capturing absurd split-second moments and subtle glances, Erwitt's work is truly masterful. He likes children and dogs.
In 1953 freshly decommissioned from military service, Elliott Erwitt was invited to join Magnum Photos as a member by its founder Robert Capa. To date he continues to be an active member and one of the leading figures in the competitive field of photography.
Elliott Erwitt is said not to like talking about his photos as they talk for themselves. In the conversation between him and Ettore Gualtiero Robbiani, Clariden Leu's art specialist and curator of the in-house private art collection, Elliott Erwitt's evident sense of humour showed in his very witty answers and made him perennially quotable. Enjoy!
Elliott Erwitt, welcome to Zurich. How are you?
Most of the parts are working!
I have to confess I am really fascinated by you. What is this egg about?
Everybody has a tag here and I felt lonesome having no tag.
You are an eyewitness to history and a dreamer with a camera. You took some of the most memorable photos of the century. Where do you see your cultural roots?
Photographers don't need to have roots.
Do you ask for permission taking somebody's photos?
You never ask for permission. You shoot first and hope that they don't realise. In Japan, it is very easy to be a photographer because everybody is. In Muslim countries it is hard as nobody likes their picture to be taken. In France, they have privacy laws, if people see themselves in the magazine, they can sue you if you don't have a permission.
Have you been sued ?
I was sued by people who thought that they were in the picture but they weren't.
How did your interest in photography raise?
Because of family circumstances, I was on my own since the age of 16 and I had to make a living. Taken photographs was a good way. You don't have a boss. My only permanent job that I ever had was with the US military army. Everything else has been freelance.
Did you like the army?
Did you have your camera with you?
Always. I took some of my best pictures when I was in the army.
What is today your favourite camera?
I don't have a favourite camera. I divide between my professional and personal work. For clients, you have to use the tools you need to achieve the results that your clients expect. For my own personal work, I walk around with a small camera, my Leica usually and that is quite seperate. One thing is for business, one thing is for hobby.
And talking about influences? What were your early influences in photography?
My early influences were Italian films after the war, neo-realist films of Fellini, Rosselini, people like that. That was my main influence and apart from that the photography of Henri Cartier-Bresson which are the gold standards in my view of photography.
When it comes to being influenced you named Edward Steichen as a mentor. How did he influence you?
He didn't influence me, he was just very helpful at that time. I was very young and I could use some help. He got me my first job by calling somebody up. He could do that, he was a very powerful man. My influences were as I mentioned before.
You once said that photography is a craft that everybody with normal intelligence could learn? But to take it beyond the craft is when the magic comes in? How do you actually approach your magic moments in a photo? Is it all staging, set-ups?
I don't get up in the morning and expect to do magic. I think that magic is in the eye in the beholder. You don't plan things. Good photography is not planned unless it is work which is planned. Photography which is interesting to me is simply an art of observation, organising elements, making fine prints.
Coming to magic moments. In your career, you portraited Marilyn Monroe. I tend to say that you showed her in a different way than we know her. How was Marilyn as a person?
I was afraid that you asked that. I am always asked that question. She was very nice, very photogenic. She looked better in pictures than in real life. Also she looked pretty good in real life as well. She was a sensitive person, a little bit nuts. She was very kind to me.
Whom of the famous persons that you met was meaningful to you?
Famous people are ordinary people that became famous. President Kennedy, Fidel Castro, of course that is interesting. Those people are very historic figures. And the problem of taking a picture of those famous people is exactly the same than taking it of ordinary people.
When you mentor young photographers what are looking for in their work?
Visual sense, application, a kind of burning ambition because it is very difficult to succeed in photography. Digital photography makes it easy to become a photographer but hard to become a good one. So you look for energy, for perserverance, and as I said most importantly for visual sense.
What about ego? Do you need a strong ego?
A strong ego gets generally in the way of things. People don't react very well to people with a strong ego. If you have it, keep it private.
Who is your favourite photographer living or dead?
The ones that are in my agency Magnum. Henri Cartier-Bresson is the champion of them. There are some that are very promising. Photographers who work for the passion, those are the interesting ones. The ones only on assignment are not the interesting ones, they are just earning a living.
I am not a collector. But I have exchanged with some of my friends.
This year, you received the Infinity Award 2011 for Lifetime Achievement from the International Center of Photography. Can you please describe what it is like to receive that honour? It is the lifetime Oscar of photography.
It is a little bit embarrasing. It seems like your life is over. You get a nice dinner, a little statue, people think that you are okay. But it really shouldn't influence you that much.
You son Misha is a photographer as well. When he told you about his future plans, how did you react? What advice did you give him?
Get a dayjob! But here is an amusing anecdote: When my father retired, he decided to become a photographer because he wanted to follow in his son's footsteps which I thought was very sweet.
Thank you Mr Erwitt for coming!
Thank you all for showing up! I couldn't imagine that I am that interesting.
What an honour: Elliott Erwitt with me.
Finally we definitely know who is the designer behind Kate Middleton's wedding gown. It's Sarah Burton, the McQueen designer. I was right with my speculation a few weeks ago.
Kate, who is now Princess Catherine, or Catherine, Duchess of Cambridge, stunned the crowd in an English and French Chantilly lace gown worn with a 2.70m long train and a silk tulle veil. The ivory duchesse satin shoes were also handmade by the McQueen team.
The look reminded of Princess Grace's wedding dress in 1956. Sarah Burton captured Kate's style in the right way, very classy and kind of simple for the house of McQueen. Only the draping at the back side of the dress seemed like a reference to the late designer. The Cartier tiara was lent to the bride by the queen.
Kate carried a secret love message by including "sweet william" flowers in her bridal bouquet.
Oh what a royal wedding – congrats to the newly wed couple!


This is very close to the last in the series on what to do with a whole pumpkin. I started with a pumpkin roasting 101 and guts bread, moved on to making soup and now curry. This is one of those recipes where the quantity and type of vegetable really doesn't matter all that much. I happened to have carrots, spinach and potatoes on hand so I threw it in with the mix. You can follow this recipe to the letter or add your own random vegetables looking sad and lonely in the drawer. This is the perfect recipe for shriveled carrots, droopy greens or that last bit of wrinkled onion you have yet to use from last weeks groceries. The flavor of the pumpkin is subtle and if you don't have pumpkin, any squash will do.
Another note: If you don't have time to roast your pumpkin or squash then throw it in early, with the carrots and let the whole thing simmer a little longer until it's soft. I just so happen to be roasting pumpkin like crazy around here due to the three whole pumpkins staring me down. While this recipe was astounding, I think I may be done with pumpkin for at least a week.
I can now see that when people choose to eat what is in season, they eat so much that they become tired of the food until it is in season once again. The ability to restrain yourself from buying strawberries in December means they will taste just that much better in March and April. The fact that they won't have to travel hundreds or thousands of miles just to get on your plate will also help satisfy your desire.
I don't know about you, but I'm not at my best after I have traveled a while. I'm sure those strawberries aren't much different. In terms of self restraint, I'm probably one of the worst. When I want a food item, I want it today, now, right this minute. I'm learning, however, sometimes it's better to wait. While I may want a strawberry in the warmth of my heated home in the middle of December, I know it will not taste nearly as good and thus leave me unsatisfied, until I can pluck it from my own garden in April.
While I know that I can't begin to wait for all things to come in season, I can choose to hold off on at least a few. This choice, helps me support my local farmers and decrease the amount of fuel and energy that will affect the planet for my son. It may just be a pint of strawberries in December, but it could mean one less farmer in my neighborhood gives up. One extra breath of fresh air for myself and my family. Just one. While I will always be far from perfect in any area of my life, I try to make at least one choice like this every day.
Heat 2 Tbsp oil in large pot. Add peanuts and sauté until roasted. Remove peanuts from pot and set aside. Sauté chicken breast in 2 Tbsp oil until no longer pink in the middle (about 5-8 min). Remove from pot. Sauté carrots, potato and onion in pot with more oil until softened. Add garlic and sauté another 2 minutes. Dump in can of coconut milk and add curry paste/powder.
Bring to boil. Turn down heat and let simmer about 10-15 minutes, covered, or until all vegetables are soft. Add pumpkin and spinach and simmer another 5 minutes. Serve in bowls and top with roasted peanuts. Enjoy this curry and your choice to eat in the season.


text:
Five Prime's restructuring claims more jobs
Dollar Photo Club
Jacob Bell @realjacobbell
Dive Brief:
Five Prime Therapeutics announced Thursday a restructuring that will eliminate roughly 70 jobs before the end of 2020, with about 70% of the cuts set for this year.
As part of the restructuring, Five Prime intends to sublet either a "significant portion" or the entirety of its 115,000-square-foot headquarters in South San Francisco, California. The company expects office space and workforce reductions, along with other measures, will result in $20 million worth of annual cost savings that will help to extend its cash runway.
In January, Five Prime announced a separate restructuring meant to focus resources around its five clinical-stage cancer drugs. That plan eliminated 42 positions, mostly from research, pathology and manufacturing departments. At the end of last year, Five Prime reported having 209 full-time employees.
Dive Insight:
Shareholder confidence in Five Prime has waned since late 2016, when shares in the California biotech went for $61 apiece. By Friday morning, they were trading at $4.20.
The company's business revolves around cancer drugs, an area of development that has become exceptionally crowded and, therefore, more difficult to hold investor attention. Five Prime's clinical-stage pipeline includes three proprietary drugs — bemarituzumab, FPA150 and FPT155 — as well as two drugs from a partnership with Bristol-Myers Squibb.
The two most advanced of those assets are bemarituzumab and one of the Bristol-Myers collaboration drugs, cabiralizumab. The former is an FGFR-targeting antibody that's in Phase 3 testing as a treatment for gastric cancer, while the latter is a CSF-1 receptor inhibitor under investigation in mid-stage studies of pancreatic and billary tract cancer patients.
Further development of Five Prime's three wholly-owned drugs now rests on a "small research group" that the company expects to have following its latest shake up. By 2020, there should be less than 100 employees if the restructuring goes as planned.
Jacob Bell / BioPharma Dive, market data
Raymond James analyst Steven Seedhouse wrote in a note to clients that the additional restructuring is "unfortunately not surprising," due to the company's cash burn rate and the ambiguity around whether any of its assets can soon be monetized. Seedhouse also highlighted how the company's interim CEO, William Ringo, has been taking a critical look at the business.
"My immediate focus as CEO has been to conduct a review of Five Prime's operations with the goal of ensuring long-term sustainability and value creation. This restructuring provides the cash runway to prioritize future pipeline investments based on clinical data readouts in 2020," Ringo said in an Oct. 10 statement.
"It also allows us to evaluate long-term strategies to grow our pipeline," he added. "We acknowledge this decision impacts many talented employees who helped build Five Prime into a clinical-stage company. We are grateful for their contributions and hold them in high regard."
Five Prime estimates the new restructuring will cost around $3 million due to severance payments and other associated expenses.
The company recorded $38 million worth of cash and cash equivalents and $176 million in marketable securities by the end of June. The company is reaffirming its financial guidance, and expects to close 2019 with $148 million to $153 million in cash, cash equivalents and marketable securities.
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redpajama_set_name: RedPajamaCommonCrawl


text:
The Nature of Data Centers − Mél Hogan and Asta Vonderau
'Engines of the cloud,' 'brain of the beast,' 'archives of digital capitalism,' 'factories of the 21st century' – these, and similar metaphors, are frequently used to describe industrial scale data centers and the cloud industry itself. Data centers are highly securitized buildings, often located out of public sight, that hide a rapidly growing industry for storing and processing data. While most internet users still might not be aware of the actual significance of data centers, internet infrastructure providers and other experts have come to realize the complex entanglements of the data center industry with political and social life. Specifically within the social sciences and the humanities, scholars have discussed data centers in regard to their architectural form, problematized their water and energy consumption, analysed the profit motivations and the low contributions of the industry to local labour market developments.
This special issue of Culture Machine brings together scholars from a broad range of disciplines such as anthropology, architecture, media and communication studies, and fine arts, who have engaged with data and cloud infrastructures in their academic or artistic work. Taking data centers as technological apparatus as a starting point, this issue aims to discuss the cloud's philosophical, political, social, and environmental impacts and maps the diverse sociotechnical assemblages which emerge in the course of cloud infrastructuring processes. How do the infrastructures of the cloud integrate into local political contexts and industrial landscapes? How do the cloud's technologies relate to the emergence of specific forms of subjectivity, sociality, and urbanity? How can the barely visible and secret industrial spaces of the cloud be made visible and opened up for public engagement? And what does the study of data centers tell us about our current social moment?
As the Editors of the issue, we have long been interested and philosophically invested in data centers and the materiality of the cloud. For this issue, we draw from gatherings and workshops, both on and offline, that have created a community of artists and scholars interested in these questions. Specifically, many of the contributors were present at the workshop in Stockholm organized by Asta Vonderau: 'Data Centers: Investigating Socio-Technological Assemblages of the Cloud' (November 2017), where we met at Bahnhof Data Center and at Stockholm University to share our work1. Other contributors took part in a collection of articles on the same topic, co-edited by Alix Johnson and Mél Hogan, in Imaginations: Journal of cross-cultural image studies 'Introducing location and dislocation: global geographies of digital data' (September 2017).2 Forthcoming, and featuring many of these voices, is a podcast co-created by Mél Hogan and Sean Willett at the University of Calgary, about the 'data center industrial complex' and its implications in terms of the environment, surveillance, and genomics.3
For this issue of Culture Machine we invited artists and scholars to contribute texts that spoke to specific questions related to their engagement with and within data centers. We believe that this interdisciplinary and open format gives us a better grasp of the complexities of the cloud which have not until now been fully assessed, described, grappled with, and theorized specifically as 'the nature' of data centers.
Based on empirical examples and case studies, the articles in this issue describe how data centers are normalized and naturalized (Taylor, Vonderau, Johnson, Meyer). They show how data center industrial buildings and sites materialize in particular places and become integral (even if securitized and barely accessible) parts of local industrial and natural landscapes, as well as of collective narratives and individual aspirations. Imaginaries of the cloud as omnipresent, automated, and ephemeral contribute to how local actors perceive data centers, as inevitable material background of today's connected society – just like air or nature.
The contributions point to socio-technological intimacies that emerge between cloud infrastructures and their localities in the process of infrastructural normalization. Such intimacies come into being in various ways: through human engagement with digital technologies (Willet); through flows of air, energy and other natural resources (Vonderau, Parker); or as entanglements between past and present industrial developments and social relations (Johnson, Levenda and Mahmoudi). At the same time, the normalcy of data centers and their seemingly 'natural' presence is also being questioned. Our contributors follow the trouble that may come with normalization processes, analyzing such processes as governmental acts and managerial strategies (Pasek, Levenda and Mahmoudi). They show, for instance, how 'nature' not only becomes instrumental as a source of energy but also a greenwashing strategy for the data center industry.
Readers of the essays are invited to follow the entanglement of data centers along the flows of energy and resources, and across their carbon cycles, in order to trace their unevenly distributed social and environmental effects, and to ask for a 'place-marked form of accountability' (Pasek). By acknowledging the tremendous amounts of academic research dedicated to the topological aspects of the cloud, our contributors also highlight the need to take into account its temporal dynamics, that is, to study data centers as 'spaces in time' (Fish), to contextualize them in local histories (Meyer, Johnson, Vonderau, Parker), and to trace paces and rhythms of data centers' infrastructuring (Parker). Some contributors refer to the different temporalities of global markets and local political processes, the impermanence of data centers and their promises of economic prosperity (Velkova) or to the anxiety and inevitability of interruptions (Fish). In the light of such a temporal perspective, data centers appear as less monolithic and 'natural', but rather as short-lived and changeable.
Several authors critique the focus on non-human infrastructural materiality which dominates existing research on data infrastructures (Taylor, Meyer). In their view, such perspectives buy too easily into commercialized images of data centers as depeopled and purely technological spaces, thus risking to ignore questions of labour, politics, ownership, and power. Why do we so easily accept the idea of the data center as an automated space, ignoring the work of its construction and maintenance performed by so-called 'indirect employees' (Meyer)? Why don't we regard the cloud as public in the first place, rather than as a private and technological space in dire need of political regulation and public negotiation? Our contributors argue for a sceptical view on the supposedly non-human nature of data centers; they make the very strategies of dehumaning, obscuring, subcontracting, and privatizing a key object of analysis.
We hope you enjoy the issue and the journal relaunch, and we would like to sign off by thanking all our peer-reviewers as well as CM Editors – Rafico Ruiz and Gabriela Méndez Cota – and especially Emma Charles who created this issue's cover image, a still from her film White Mountain (2016). Thank you!
1. Organized by Asta Vonderau 'Data Centers: Investigating Socio-Technological Assemblages of the Cloud', 16-17 November 2017, Stockholm University https://www.socant.su.se/english/about-us/events/investigating-data-centers-socio-technical-assemblages-of-the-cloud-1.356901
2. 'Location and Dislocation: Geographies of Digital Data," edited by Alix Johnson and Mél Hogan', Imaginations: Journal of Cross-cultural Image Studies, September 8(2). http://imaginations.glendon.yorku.ca/?p=9947
3. The Data Center Industrial Complex [DCIC Podcast] by Mél Hogan and Sean Willett https://melhogan.com/website/dcic-podcast/


"A penny saved is a penny earned". That's a good old American quote just about everyone knows, references and many live by. Unfortunately when it comes to purchasing building materials for the structure you will one day call home, this might not always be true. Another famous saying comes to mind here "You get what you pay for". So, what is the balance between saving some of your hard earned dough and acquiring materials for your home that will last? Let's take a look at a few scenarios.
Mr. and Mrs. homeowner are about to replace the roof on the home they just purchased. They have a few other projects in mind for their new home as well so they are working with a pretty tight budget. A great local roofing contractor comes over to give them an estimate and offers two options.
A) Replace roofing system with an architectural laminate shingle and a complete roof system. Upgraded system warranty, grade A shingle, limited life time 50 year material coverage.
Wow, what a price difference. Mr. and Mrs. Homeowner are very happy with the price of roofing system B, after all they are going to save over $3,000. This is a common misconception that we deal with in the trades. The problem with this is revealed as you really begin to paint a picture of what you are getting as far as quality and the life span of the products installed.
Taking a deeper look into what Mr. and Mrs. homeowner are actually getting might just make you change your mind on whether or not they really saved any money. Roofing system B is a 3 tab shingle which is rated as a 25 year roof. It has a true roof life of about 8-13 years. Roofing system A is a thicker shingle with a 50 year limited lifetime rating. The roof life of this shingle is about 17-25 years. If you consider the fact that they will be replacing roofing system B two times in the lifespan of roofing system A then did they really save any money? Re-roofing or construction on your home can be a very invasive process we well, do you really want to do it twice? There are other facts to consider as well such as damage to the roof deck or framing structure do to failure of poor materials that can cost extra money. If you look at things over the long run, purchasing quality materials is going to protect your family, home and save you money.
Play it safe! Always consult a professional licensed, bonded and insured contractor in your area before taking on a construction project. Estimates are usually free and a local contractor will always be up to speed with current building codes and the best materials for your specific job.
This information has been provided by Joel Beattie (joel@chasenw.com) of Chase Construction NW Inc; roofers Tacoma Wa and roofers Sumner Wa.


text:
Largest mass execution in U.S. history — December 26
December 26, 1862 — Mankato, Minnesota (Library of Congress)
From This American Life. . .
Growing up in Mankato, Minnesota, John Biewen says, nobody ever talked about the most important historical event ever to happen there: in 1862, it was the site of the largest mass execution in U.S. history. Thirty-eight Dakota Indians were hanged after a war with white settlers. John went back to Minnesota to figure out what really happened 150 [now 152] years ago, and why Minnesotans didn't talk about it much after. Listen to the full episode here: #479: Little War on the Prairie
Real Housewives of Gettysburg
Hat tip to Dana Shoaf, and to The Gettysburg Compiler.
Meg Sutter '16 and Megan McNish '16 report from Gettysburg College's Special Collections in Musselman Library. In this episode, they present a Civil War housewife used by Lewis W. Tway of the 147th New York.
Hard times in the Cradle of Secession. . .
The Keeping Room debuted at the Toronto International Film Festival three months ago. It is "a film that tells the story of 3 Southern women (2 of them sisters, and the third, their long-silent family slave) who are forced to defend their home in the last days of the war, against a large group of soldiers who have broken off from the Union Army."
Read a review by Zeba Blay here.


text:
Paul Bramadat
Religion, Culture and Society Program; and History Department
M.A. (McGill); PhD (McMaster)
Office: Sedgewick Vandekerkhove Wing B102e
bramadat@uvic.ca
About our Director
I received my PhD in religious studies from McMaster University (1998), my MA in religion and culture from McGill University (1993), and my BA in religious studies from the University of Winnipeg (1990). I taught in the Religious Studies Department at the University of Winnipeg from 1998 until 2008. In addition to directing the CSRS since 2008, I hold teaching appointments in the Department of History and the Religion, Culture and Society Program at the University of Victoria.
I am interested in the ways we imagine religion and spirituality when we talk about diversity, health, security and civil society. Most of my work concerns religion, spirituality, and secularity in North America and Western Europe, although I am increasingly interested in the relationships between these societies and global forces. Recently, my interests have grown to include the confluence of religion, environmentalism and bio-regionalism in North America.
My first book, The Church on the World's Turf (Oxford 2000), examined the ways religious sub-cultures can thrive in largely secular environments. Other books include: Religion and Ethnicity in Canada (Pearson 2005), and Christianity and Ethnicity in Canada (University of Toronto Press 2008), both edited with David Seljak; International Migration and the Governance of Religious Diversity (McGill-Queen's University Press 2009), edited with German sociologist Matthias Koenig; Spirituality and Hospice Palliative Care (SUNY 2013), edited with Kelli Stajduhar and Harold Coward; and Religious Radicalization in Canada and Beyond (University of Toronto Press 2014), edited with Lorne Dawson; Public Health in the Age of Anxiety: Religious and Cultural Roots of Vaccine Hesitancy in Canada (University of Toronto Press 2017) edited with Canadian scholars and scientists, Maryse Guay, Real Roy, and Julie Bettinger; and Urban Religious Events: Public Spirituality in Contested Spaces (Bloomsbury 2021), edited with European sociologists, Mar Griera, Julia Martínez-Ariño, and Marian Burchardt. Religion at the Edge: Nature, Spirituality, and Secularity in the Pacific Northwest, edited with Patricia O'Connell Killen and Sarah Wilkins-Laflamme, is now published by the University of British Columbia Press.
My articles have appeared in Religion, State and Society, the Journal of the American Academy of Religion, Canadian Ethnic Studies, Studies in Religion, Ethnicities, Ethnologies, and the Journal of International Migration and Integration, as well as magazines such as Canadian Diversity, The Ecumenist and Canadian Issues. I am also an Associate Editor at the Journal of the American Academy of Religion.
View all Faces of UVic Research: Paul Bramadat.
2021. Religion at the Edge: Nature, Spirituality, and Secularity in the Pacific Northwest. Bramadat, Paul, Patricia O'Connell Killen, Sarah Wilkins-Laflamme, eds. Vancouver: University of British Columbia Press. 278 pp.
2021. Religion, Spirituality and Irreligion in The Best Place on Earth: An Overview. In Religion at the Edge: Nature, Spirituality, and Secularity in the Pacific Northwest. 20 pp.
2021. Reverential Naturalism in Cascadia: From the Fancy to the Sublime. In Religion at the Edge: Nature, Spirituality, and Secularity in the Pacific Northwest. 19 pp.
2021. Conclusion. Co-authored with P. O'Connell Killen. In Religion at the Edge: Nature, Spirituality, and Secularity in the Pacific Northwest. 13 pp.
2021. Urban Religious Events: Public Spirituality in Contested Spaces. Bramadat, Paul, Mar Griera, Julia Martínez-Ariño, Marian Burchardt, eds. London: Bloomsbury. 328 pp.
2017. Public Health in the Age of Anxiety: Religious and Cultural Roots of Vaccine Hesitancy in Canada. Paul Bramadat, Maryse Guay, Julie Bettinger and Réal Roy, eds. Toronto: University of Toronto Press. 398 pp.
2014. Religious Radicalization and Securitization in Canada and Beyond. Paul Bramadat and Lorne Dawson, eds. Toronto: University of Toronto Press. 332 pp.
2013. Spirituality in Hospice Palliative Care. Paul Bramadat, Kelli I. Stajduhar and Harold Coward, eds. Albany: SUNY Press. 210 pp.
2009. International Migration and the Governance of Religious Diversity. Paul Bramadat and Matthias Koenig, eds. Montreal: McGill-Queens University Press. 340 pp.
2008. Christianity and Ethnicity in Canada. Paul Bramadat and David Seljak, eds. Toronto: University of Toronto Press. 444 pp.
2005. Religion and Ethnicity in Canada. Paul Bramadat and David Seljak, eds. Toronto: Pearson Education Canada. 252 pp. [Reprinted in 2009 by the University of Toronto Press.]
2000. The Church on the World's Turf: An Evangelical Christian Group at a Secular University. New York: Oxford University Press. 205 pp.
2019. A Bridge Too Far: Yoga, Spirituality and Contested Space in the Pacific Northwest. Religion, State and Society 47 (4). 491-507.
2014. Don't Ask, Don't Tell: Refugee Settlement and Religion in British Columbia. Journal of the American Academy of Religion 82 (4): 907-937.
2013. Vaccine Hesitancy: An Overview. Co-authored by Eve Dubé, Caroline Laberge, Maryse Guay, Paul Bramadat, Réal Roy, and Julie Bettinger. Human Vaccines & Immunotherapeutics 9 (8) 1–11.
2013. Windows into the Canadian Approach to Managing Religion: Refugee Policies and the Office of Religious Freedom. Working Paper from the Responding to Complex Diversity in Europe and Canada Project. 6530 wds.
2012. 'If perhaps only in Canada': Reflections on Christian Joppke's Citizenship and Immigration. Ethnicities 12 (6): 11-16.
2011. Religion, Race, and Remembering: Indo-Caribbean Christians in Canada. Journal of the American Academy of Religion 79 (2): 315-345.
2011. They were always such nice boys: Religion, Radicalization and Securitization in Canada and Beyond. Our Diverse Cities 8: 54-58.
2009. Socio-economic conditions – Manitoba and Saskatchewan. Canadian Journal for Social Research 2: 227-234.
2008. Religion and Public Policy in Canada: An Itinerary. Studies in Religion 37 (1): 121-143.
2005. Toward a New Politics of Authenticity: Ethno-Cultural Representation in Theory and Practice. Canadian Ethnic Studies 37 (1): 1-20.
2005. Religion, Social Capital and "The Day that Changed the World." Journal of International Migration and Integration 6 (2): 201-218.
2001. For Ourselves, Our Neighbours, Our Homelands: Religion in Folklorama's Israel Pavilion. Ethnologies 23 (1): 211-232.
2001. Shows, Selves, and Solidarity: Ethnic Identity and Cultural Spectacles in Canada. Canadian Ethnic Studies 33 (3): 78-98.
1996. Reflections on the Effacement of Women: An Examination of Irigaray's Critique of Levinas. The Journal of Religion and Culture 10 (Spring): 30-46.
1992. The Jewish Argument Against Homosexuality in Focus in Love and Sex by Robert Gordis. The Journal of Religion and Culture 6 (Spring): 27-42.
Chapters in Books
2021. A Bridge Too Far: Yoga, Spirituality and Contested Space in the Pacific Northwest. In Urban Religious Events: Public Spirituality in Contested Spaces. 23 pp.
2021. Introduction. Co-authored with co-editors. In Urban Religious Events: Public Spirituality in Contested Spaces. 20 pp.
2020. Afterword: Women and Religion in Global and Local Perspective. In Women and Religion in the International Arena. Morny Joy, ed. Sheffield: Equinox Publishing. Pp. 295-300.
2020. Complicating Religious Identities through the Social Relations of Prayer. Co-authored with Rachel Brown and Sylvia Collins-Mayo. In Prayer as Transgression: The Social Relations of Prayer in Healthcare Settings. Sheryl Reimer Kirkham, Sonya Sharma, Rachel Brown, and Melania Calestani, eds. Montreal: McGill-Queen's University Press. Pp. 122-137.
2019. Defiant Subjects: Radicals, Refugees, and Refuseniks. In Modern Subjectivities in World Society: Global Structures and Local Practices. D. Jung and S. Stetter, eds. London: Palgrave Studies in International Relations. Pp. 127-147.
2018. He Said, We Said: Religion in the York University Controversy of 2013-2014. In A Critical Analysis of Religious Diversity. J. Borup, W. Hoverd, and L. Kuhle, eds. Leiden: Brill. Pp. 208-229.
2017. Introduction: Seeking a Better Conversation. In Public Health in the Age of Anxiety: Religious and Cultural Roots of Vaccine Hesitancy in Canada. Pp. 5-15.
2017. Crises of Trust and Truth: Religion, Culture, and Vaccine Hesitancy in Canada. In Public Health in the Age of Anxiety: Religious and Cultural Roots of Vaccine Hesitancy in Canada. Pp. 16-55.
2017. Continuing the Conversation. Co-authored with J. Bettinger and M. Guay. In Public Health in the Age of Anxiety: Religious and Cultural Roots of Vaccine Hesitancy in Canada. Pp. 355-65.
2017. Appendix. Co-authored with J. Bettinger and M. Guay. In Public Health in the Age of Anxiety: Religious and Cultural Roots of Vaccine Hesitancy in Canada. Pp. 365-376.
2017. Growing Up and Getting Along During a Cosmic War: Youth Radicalization and Religious Minorities in Canada. In Immigrant Youth in Canada: Theoretical Approaches, Practical Issues, and Professional Perspectives. S. Wilson-Forsberg and A. Robinson, eds. Toronto: Oxford University Press. Pp. 288-305.
2016. Managing and Imagining Religion in Canada from the Top and the Bottom: 15 Years After. In Religion and the Exercise of Public Authority. B. Berger and R. Moon, eds. Toronto: Hart Publishing. Pp. 61-78.
2014. The Public, the Political and the Possible: Religion and Radicalization in Canada and Beyond. In Religious Radicalization and Securitization in Canada and Beyond. Pp. 3-34.
2014. Conclusion. Co-authored with Lorne Dawson. In Religious Radicalization and Securitization in Canada and Beyond. Pp. 301-314.
2013. Introduction. Co-authored with Kelli I. Stajduhar and Harold Coward. In Spirituality in Hospice Palliative Care. Pp. 1-11.
2013. Religion, Spirituality, Medical Education, and Hospice Palliative Care. Co-authored with Joseph Kaufert. In Spirituality in Hospice Palliative Care. Pp. 60-85.
2013. Conclusion. Co-authored with Kelli I. Stajduhar. In Spirituality in Hospice Palliative Care. Pp. 164-171.
2013. Between Secularism and Post-Secularism: A Canadian Interregnum. Co-authored with David Seljak. In The Secular State and Religious Diversity: Secularism, Tolerance, and Accommodation. A. Laliberté, B. Berman, and R. Bhargava, eds. Vancouver: University of British Columbia Press. Pp. 97-119.
2011. Immigration. In Encyclopedia of Global Religion. Wade Clark Roof and M. Juergensmeyer, eds. Thousand Oaks, CA.: Sage. Pp. 545-546.
2009. Religious Diversity and International Migration: National and Global Dimensions. In International Migration and the Governance of Religious Diversity. Pp. 1-28.
2008. Charting the New Terrain: Christianity and Ethnicity in Canada. Co-authored with David Seljak. In Christianity and Ethnicity in Canada. Pp. 1-40.
2008. The Discourse of Loss and the Future of Christianity in Canada. Co-authored with David Seljak. In Christianity and Ethnicity in Canada. Pp. 380-400.
2005. Beyond Christian Canada: Religion and Ethnicity in a Multicultural Society. In Religion and Ethnicity in Canada. Pp. 1-29.
2005. Toward a New Story about Religion and Ethnicity in Canada. Co-authored with David Seljak. In Religion and Ethnicity in Canada. Pp. 222-234.
Under review and also of potential interest….
Wellness in the Wild: Reverential Naturalism in the Pacific Northwest. In New Spiritualties and the Culture of Well-being. Geraldine Mossiere, ed. Berlin: Springer. Under review. 19 pp.
Religion, Culture, and the Politics of Vaccine Hesitancy: Perspectives of Parents, Pundits, and Physicians. In The Routledge Handbook of Religion, Medicine, and Health. Dorothea Lüddeckens and Jens Schlieter, eds. Milton Park: Routledge. Under review. 37 pp.
Religion, Discrimination and the Canadian Experience: Lessons for Elsewhere? In Social Discrimination, Spirituality and Religious Beliefs: A Challenge for Anthropologists and Social Workers. Alberto Montes and Fina Antón, eds. Granada: University of Granada Press. Under review. 15 pp.
2020. Religion and Bioregionalism in Cascadia: The Trouble with Categories. MMG Working Paper 20-05 at the Max Planck Institute for the Study of Religious and Ethnic Diversity. 26 pp.
2020. Religion, Spirituality, and Secularity in the Pacific Northwest: Major Themes. MMG Working Paper 20-02 at the Max Planck Institute for the Study of Religious and Ethnic Diversity. 26 pp.


text:
Sensors To Monitor Pathogens and Explosives Being Developed At UH
Researchers at the University of Houston are developing next generation sensors that can be used to detect microbial pathogens, explosives and other dangerous materials. Below is an excerpt from chemicalonline.com detailing their efforts.
Monitoring everything from explosives to tainted milk, materials for use in creating sensors for detection devices have been developed by a University of Houston (UH) chemist and his team. "There are many dangerous substances, pollutants and infectious bacteria we are constantly exposed to," said Rigoberto Advincula, a highly cited materials scientist at UH. "Our work is poised to assist in such efforts as rapidly detecting explosives or banned substances in airports for homeland security, as well as monitoring commercial products like milk and pet food for substandard additive products. There is a need to measure this quantitatively and in a rapid manner."
In a two-stage effort on which a provisional patent has been filed, Advincula's team fabricated the polymer materials and then built a device that was used as a sensor. The work is based on what he calls "the artificial receptor concept." This is akin to an enzyme functioning as a biochemical catalyst within a cell, like an antibody, binding with specific molecules to produce a specific effect in the cell. The elements in Advincula's work, however, deal with metals and plastics and are called molecular imprinted polymers (MIP), a concept also used for making plastic antibodies. These polymers show a certain chemical affinity for the original molecule and can be used to fabricate sensors. The group's next step is to put this film on portable devices, thus acting as sensors.
"Our materials and methods open up these applications toward portable devices and miniaturization. Our device will allow, in principle, the development of hand-held scanners for bomb detection or nerve agent detection in airports," Advincula said. "This means accurate answers in a rapid manner without loss of time or use of complicated instruments. We can achieve very high sensitivity and selectivity in sensing. The design of our molecules and their fabrication methods have been developed in a simple, yet effective, manner." In the coming year, the researchers hope to expand the work to many other types of dangerous chemicals and also to proteins given off by pathogens. Ultimately, they plan to create portable hand-held devices for detection that will be made commercially available to the general public, as well as being of interest to the military.
The culmination of a year's work, the research being published simultaneously in three journals is a record for Advincula's group. These publications – Macromolecules, Applied Materials & Intefaces, and Biosensors & Bioelectronics – are among some of the most prestigious and highly cited in this area of study.
Rapid Gene Sequencing
Below is a very interesting article on the future of gene sequencing from The Dark Daily, a website for clinical laboratory and pathology news and trends (http://www.darkdaily.com):
Rapid gene sequencing is catching the interest of progressive anatomic pathologists. These medical laboratory professionals are interested in using rapid gene sequencing technology to allow them to study tens and hundreds of genes on a patient specimen.
The technologies used in rapid gene sequencing are being developed and improved by a handful of biotech companies who are racing each other be first to deliver systems to the marketplace that can sequence whole human genomes at a cost of $1,000 or less. Some innovative medical laboratories are beginning to acquire these sequencing systems and explore how they might be used for clinical pathology laboratory testing.
At a recent meeting in Washington, D.C., researchers involved in whole human genome sequencing reported on the latest breakthroughs. However, there was sober recognition of how much work remains to be done before doctors will be able to use multi-gene analysis to diagnose disease.
The meeting of the American Society for Human Genetics (ASHG) included a session titled, "Genomic Medicine: Current Status, Evidence Dilemmas, and Translation into Clinical Practice." According to a Genetic Engineering & Biotechnology News article, attendees discussed "a real-world view of the opportunities and obstacles in acquiring and applying the data from whole-genome sequencing (WGS) and genome-wide analysis (WGA) studies."
The article goes on to note that "although the technology is available to sequence an individual's genome, it is still a relatively costly endeavor, and how best to analyze and interpret the clinical significance of the results is not yet clear."
Bridging the Practicality Gap in Genetic Testing
At the conference, excitement ran high over new instruments and algorithms that promise to speed genome sequencing ten-fold. High-density chips containing 1 million variant markers will soon be replaced by arrays capable of identifying up to five million single nucleotide polymorphisms (SNP)—variations in DNA occurring in at least 1% of the population that scientist believe might cause predisposition to certain diseases.
Kelly Ormond, Associate Professor and Director of the Master's program in human genetics and genetic counseling at Stanford University, and the session's moderator, noted that there are "competing forces" at work driving the industry's advancements—those who seek early adoption of the technology in clinical settings, and those who advise caution and continued research.
Euan Ashley, D.Phil., an Assistant Professor of Medicine and Director of the Center for Inherited Cardiovascular Disease at Stanford University, noted that current genomic databases need to be "reconfigured in a way that would make them easier to interpret and use in a clinical setting." Ashley also noted that there are gaps in the data, and that the "regulatory and non-coding genome has been neglected." Also noted was the need for a method of explaining genomic data to patients.
High Throughput, Lower Cost Technologies Would Help Medical Labs
In her presentation, Debbie Nickerson, Ph.D., Professor of Genomic Sciences at the University of Washington "emphasized the impact that next-generation sequencing (NGS) and emerging third-generation single-molecule sequencing technology will have on advancing knowledge about human genome variation, along with the ability to link genetic and phenotypic variation." She described the next generation of sequencing technology as "disruptive" and "game-changing."
Examples of companies developing such technologies include:
454 Life Sciences (a Roche company)
Illumina's HiSeq sequencing by synthesis technology
Applied Biosystems/Life Technologies SOLiD system
Complete Genomics CGA platform
Pacific Biosciences' Single Molecule Real-Time (SMRT) sequencing technology
"The Chip is the Machine" semiconductor chip-based system from Ion Torrent (recently acquired by Life Technologies)
Oxford NanoPore Technologies' nanopore-based sequencing strategy
Cecelia Bellcross, Ph.D., and a fellow with the Office of Public Health Genomics of the Center for Disease Control and Prevention, discussed the lack of funding available to "support the back-end of the genomic medicine pathway—comprised of clinical testing, data interpretation and application, and outcomes—compared to the funds available for generating genomic data."
According to Genetic Engineering & Biotechnology News, Bellcross called for "funders, patients, clinicians, academician researchers, and lawyers to work together and close the gap between evidence and clinical applicability."
Clinical laboratory administrators and pathologists will want to take note of the comments at this conference that coming soon will be high-density chips that will allow researches and laboratories to sequence five million single nucleotide polymorphisms (SNP) at a time. Not only does this indicate the pace of innovation in the gene sequencing field, but it is a reminder that clinical laboratories and anatomic pathology groups will need a robust informatics solution so that they can handle all this raw data.
Sensors To Monitor Pathogens and Explosives Being ...


text:
#region license
// Copyright (c) 2005 - 2007 Ayende Rahien (ayende@ayende.com)
// All rights reserved.
//
// Redistribution and use in source and binary forms, with or without modification,
// are permitted provided that the following conditions are met:
//
//     * Redistributions of source code must retain the above copyright notice,
//     this list of conditions and the following disclaimer.
//     * Redistributions in binary form must reproduce the above copyright notice,
//     this list of conditions and the following disclaimer in the documentation
//     and/or other materials provided with the distribution.
//     * Neither the name of Ayende Rahien nor the names of its
//     contributors may be used to endorse or promote products derived from this
//     software without specific prior written permission.
//
// THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND
// ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED
// WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE
// DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE
// FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
// DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
// SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER
// CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,
// OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF
// THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
#endregion

using System;
using System.Data;
using System.Text;
using MbUnit.Framework;

namespace Rhino.Mocks.Tests.FieldsProblem
{
	/// <summary>
	/// Summary description for Bug_45.
	/// </summary>
	public class ClassThatImplementsGetHashCodeAndEquals
	{
        MockRepository mocks;

        [SetUp]
        public void Setup()
        {
            mocks = new MockRepository();
        }

        [TearDown]
        public void TearDown()
        {
            mocks.VerifyAll();
        }

		[Test]
		public void InitClass()
		{
				EmployeeInfo info = (EmployeeInfo)mocks.StrictMock(typeof(EmployeeInfo), "ID001");

				mocks.ReplayAll();

				Assert.IsNotNull(info);
		}

		[Serializable]
		public class EmployeeInfo
		{

			public EmployeeInfo(string employeeId)
			{
				if (employeeId == null || employeeId.Length == 0)
				{
					throw new ArgumentNullException("employeeId");
				}

			}

			#region Object Members

			/// <summary>
			/// Returns a string representation of this instance.
			/// </summary>
			public override string ToString()
			{
				return null;
			}

			/// <summary>
			/// Gets the hash code for this instance.
			/// </summary>
			public override int GetHashCode()
			{
				return this.ToString().GetHashCode();
			}

			/// <summary>
			/// Determines whether the specified instance is equal to this instance.
			/// </summary>
			public override bool Equals(object obj)
			{
				EmployeeInfo objToCompare = obj as EmployeeInfo;

				if (objToCompare == null)
				{
					return false;
				}

				return (this.GetHashCode() == objToCompare.GetHashCode());
			}

			#endregion
		}
	}
}

redpajama_set_name: RedPajamaGithub


Do kids read these days?
Of course they do! Not only that, but kids are getting better stuff to read than adults are. All of this is according to Stephen King in this article for Entertainment Weekly where he also explains what made Harry Potter such a success.
Hmm, for someone who isn't the biggest fan of HP, I gotta say, King made some cool points. I like how he points out that Rowling's kids don't stay kids; it's definitely true that my age group practically grew up with Harry, and could probably relate to his adventures over the entire 9 year span. And the whole "kids read more than adults" is pretty interesting. I definitely read a lot more between the ages of 8 and 13 than I ever did after I entered high school. But on the other hand, there are a lot of kids who will admit outright that they just don't like reading, and probably would only read HP because it's such a cultural craze. I guess it's just back to the old rule: Don't accuse all kids of being stupid based on the actions of a small group.


Yes, I understand that this e-zine is largely Caribbean cruises based. However, we have decided to expand somewhat to include cruises to other fun destinations.
One of our newest pages at All-Inclusive Caribbean Cruises looks at Carnival Fun Ship cruises to the hotly desired Alaskan frontier. Click here to read all about them.
1. Carnival Offers Group Cruise Special.
For a limited time, Carnival backs away from its usual group cruise policy and offers a group cruise special with a better chance for earning a free berth/passage. From now until April 30, anyone can organize a group cruise and pay nothing down. No payment is due until 120 or 150 days before the cruise departure (depends on the length of the cruise).
In addition, instead of earning one free berth/passage for every 8 cabins sold, Carnival will allow one free berth/passage for every 5 cabins sold. So, after ten (10) adults have paid, the next person will be free (except for port charges and taxes). On west coast cruises, groups only need 4 cabins sold to earn one free passage.
Contact your Travel Agent for more details and get your group cruise reserved by April 30, 2014 for sailings between November 1, 2014 and April 30, 2015.
2. Royal Caribbean Revolutionizes Main Dining.
This fall, Royal Caribbean will introduce Dynamic Dining on the first of its Quantum Class of ships, the Quantum of the Seas (debuts November 2014). If you are familiar with the main dining room and service onboard a cruise ship, this will be eliminated.
Instead of guests being assigned to one of two main dining rooms for their meals, the Quantum Class ships will have five (5) restaurants, each serving a different cuisine, to which guests may visit every night. In addition to the five (5) complimentary restaurants, there will some specialty restaurants with a cover charge and other dining options - a total of 18 places to eat!
Dining will not be the same on Quantum of the Seas this fall, and the Anthem of the Seas which debuts in spring of 2015.
Check with your Travel Agent or Royal Caribbean for more information.
We are excited to invite you to join us on a group cruise to Ocho Rios, Jamaica and Grand Cayman, Cayman Islands this October. Deposits are only $25/person and are due by April 30h. Final fares start at $413/person.
As summer approaches and everyone turns to the high seas, cruise prices go up quickly. In order to save, you must plan to sail at the right time. If possible, book your cruise for early June or late July into August. Cruise sailings then are less expensive than those late June or early July, when everyone is out of school.
May is the last month to find reasonable rates on cruise packages, before the high season of summer kicks in. Look to book your cruise in early to mid-May to get the best deals.
1. Carnival Ecstasy offers a 4-day itinerary from Miami on May 12th to Key West and Cozumel (featuring a Carnival Live Concert) starting at $269/person (double occupancy).
2. Carnival Elation offers a 5-day itinerary from New Orleans on May 3rd to Cozumel and Progreso starting at $339/person (double occupancy).
3. Norwegian Sky 4-day sailing from Miami on May 5th to Freeport, Nassau and Great Stirrup Cay (Bahamas) starting at $279/person (double occupancy).
4. Caribbean Princess offers a 4-day sailing from Ft. Lauderdale on May 19th to Cozumel starting at $499/person (double occupancy).
5. Royal Caribbean's Vision of the Seas has a 4-day itinerary from Ft. Lauderdale on May 8th to Cozumel starting at $189/person (double occupancy).
The above offers are just a few of many. Check with your Travel Agent, the cruise line directly, or let us help you.
You may book directly at PetesTravel.com or send us a Cruise Quote Request.


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» News » The Last Muster featured at Concord Museum exhibit
The Last Muster featured at Concord Museum exhibit
A special exhibition at the Concord Museum
April 18 through September 21, 2014
Based on the eponymous Maureen Taylor books, The Last Muster: Images of the Revolutionary War Generation, brings together 30 photographic portraits of people who lived through the Revolution and survived into the age of photography. Gathered by one of the nation's foremost historical photo detectives, Maureen Taylor, these rare nineteenth-century images assign faces to an un-illustrated war. Although the faces that gaze out are old and wizened, the stories they tell are of youthful bravery in the early days of the Republic. Presented in conjunction with The Shot Heard Round the World, the exhibit will be on view from April 18-September 21, 2014.