text:
Travel Blog » Middle East » Turkey » Central Anatolia » Cappadocia » Göreme » Blogs » A Visit To Mars
A Visit To Mars
Excursions From London 2008-2014
Middle East » Turkey » Central Anatolia » Cappadocia » Göreme
Published: July 14th 2012
Balloons Over Cappadocia Valley
A rather surreal sight - all these balloons dotted across the sky, and the most alien rock formations dotted along the ground.
Everything I had read and heard said that our overnight bus would drop us off in Nevsehir, from where we would be ferried by a shuttle bus to where we were staying in Goreme. Much to our sleepy surprise, the bus dropped us off directly in Goreme. Win.
Speaking of sleepy surprises, it was still around 6am by the time we had managed to sleepwalk our way up a hill and arrived at our hotel. We hear a soft, throbbing bass coming out of the hotel's front office so we knock on the door. After a couple of minutes, a bearded Turkish man with bruised eye and a bandage across his nose sleepily answers the door.
"Kelley?", croaks the man groggily.
I suppose he was expecting us. It was also a rather amusing start to our stay in Cappadocia.
Also up at that ungodly hour was Davies, who had arrived here the day before and had got up to greet us. It was nice to finally have some male company on this trip. It was also nice to finally get a few hours sleep.
The next day was pretty chilled out - after all the full-on travelling of the last
Fairy Chimney
An upmarket cave house.
few days, it was nice to not be in a rush to do anything.
After brunch we walked around Goreme, visiting tourist offices to book all our activities for our time here.
Although we were expecting to see cave houses and alien-like 'fairy chimneys', to actually see them was still surreal. Hotels (including ours, the Sunset Cave Hotel) have literally been carved into the cliffs and are basically modern, refurbished caves with electricity, and what used to be elongated, standalone domes of rock have been carved up on the inside and converted into houses. These structures really do look like something from another planet, as if you were in an alien civilisation from Star Wars. Amazing.
Booking our hot air balloon and Cappadocia tours apart, the highlight of the day was a trip to nearby Avanos, where the girls enjoyed a hammam. Davies and I didn't really fancy the idea of being scrubbed down by a big, hairy Turkish man, so we enjoyed a couple of Turkish coffees and a stroll around Avanos instead.
The area down by the river which includes a rather shaky pedestrian suspension bridge, a mosque, a riverside promenade, and Venetian-style gondolas for tourists is rather
Ihlara Valley
Cappadocia's Grand Canyon.
pleasant. Otherwise, there isn't really too much to the town.
That evening, we visited a local restaurant with a traditional Turkish set-up of low tables, cushions, no shoes and crossed legs. Pity the food didn't match the standard of the setting. I had the saclava which was nothing more than a beef and tomato stew. The quantities served were decidedly small too.
We all settled in for an early night because we had a 5am start the next day. Just like we did at the Valley of the Kings we were to embark on an early morning, hot-air balloon ride.
After being served a breakfast of Turkish bread and pastries washed down with some fruit and some coffee, we ended up boarding the balloons late and as a result missed the sunset, which in my sleepy stupor, sort of defeated the purpose of doing the balloon ride at dawn.
John, our pilot, was an Englishman and was rather cheerful. He went on to explain that the period just after dawn was in fact the calmest period of the day with the least wind, and thus was the safest time to take tourists up into the sky. OK then, so perhaps it wasn't
Like the tombs carved into the rock in Petra but not so intricate and more alien-looking.
such a waste getting up early after all. In any case it was a beautiful clear-sky morning, perfect for a balloon ride.
As well as flying our balloon, John also gave us some good insight into piloting a hot-air balloon, the area below us, life in Turkey as an ex-pat, and some jokes.
The view over Cappadocia, was as expected, pretty amazing. John also managed to get us pretty low and into some of the valleys for some real close-up shots of the Martian-like landscape. There were about a hundred other balloons also flying about at the same time which against the landscape, was quite a sight. I'll let the pictures do the talking.
Unlike in Egypt, we were not set upon by kids and donkeys begging for food when we landed but instead were treated to some cake and a glass of champagne, which doesn't taste as nice when you're sleep-deprived at 8am in the morning. John then rather amusingly and embarrassing-Dad-style, put on his pilot's hat before handing out our certificates for completing the flight. Would we have got one if the balloon went down?
After a short rest and a second breakfast back at hotel, we
View From The Lookout
Spectacular.
were picked up for our "green tour" of Cappadocia.
Out tour guide Ugur - who was a ringer for Luis Figo - was very knowledgeable and enthusiastic and wasn't shy of a joke or two, even if some of them fell a bit flat.
The first stop on our tour was at a lookout across the valley which was pretty impressive. At the viewpoint Ugur explains that rivers had eroded the sedimentary rock that existed here over millions of years to form the landscape that we see today.
The next stop was the highly anticipated Derinkuyu Underground City, which is eight levels deep. Sounds pretty cool huh?
The city was created by the Hittites who used it primarily as a place to hide from invaders. Apparently there are hundreds of these cities in Cappadocia, but only a few have been excavated and opened to the public. After the Hittites, the civilisations that ruled over the area took over the underground cities and further expanded and developed them.
As we go down into the darkness, the place feels similar to the Wieliczka Salt Mines.
On the first level underground, Ugur tells us that animals, the kitchens and the food stores were all kept
Derinkuyu Underground City
It's amazing to think that people lived down here all those years ago.
as close to the surface as possible for hygiene reasons and also so that the smoke created from cooking could leave the city as quickly as possible without smokin' the place out a la Warren G. Any smoke generated was routed through a chimney which used pumice to filter out the colour from the smoke, so that the enemies on the surface could not see it. The chimney hole was cleverly covered by a grave on the surface, when not in use.
As we go deeper underground through some pretty claustrophobic tunnels, Ugur explains to us that the tunnels were deliberately made small so that it was easier to kill invaders - the size of the tunnels only allows one invader at a time to go through them, which made them easy to pick off when they eventually encountered defenders.
When we reach the deepest levels, Ugur tells us how amazing it is that none of the floors in the underground city ever collapsed on each other, given how old these cities are and the relative lack of technology. The lower levels were created by later civilisations and include a couple of chapels.
Unfortunately, we weren't the only group touring
Underground Chapel
This was restored - it didn't actually look like this back in the day.
through the city - the place was rammed with other tourist groups and there were some serious traffic jams in some of the one way tunnels. I would love to have been able to freely explore the whole city, without anyone around. I love exploring sites like this.
The next stop on our tour was the Ihlara Valley, basically a canyon which we were about to make a short hike through.
Before the hike starts, we descend into the canyon and stop at a church that has been built into a cave, its frescoes still bright and intact. Ugur tells us that the paint used on these frescoes were egg-white-based. Apparently, this is just one of hundreds of cave churches in the valley, carved into the rocks by Byzantine monks.
It really is a lovely day for a hike, and I regret not wearing shorts. With the river running alongside us, it was a peaceful and pleasant walk, with some great scenery to boot. Another interesting fact that Ugur tells us during the walk, is that the temperature in the valley is constant which allows plants that don't normally grow in Cappadocia to actually thrive in the valley, including
The highlight of the tour.
pistachio trees.
The hike ends with lunch at an outdoor riverside restaurant, where the beef shish kebab was excellent although 5TRY (£1.80) for a can of Fanta was a bit ridiculous.
The highlight of the day was definitely the Selime Monastery, the next stop on the tour.
This was the kind of shit I was expecting to see in Cappadocia - a huge complex of tunnels, stairwells, and houses all built into a mountain.
While looking rather primitive from the outside - they are essentially caves after all - walking into the cathedral was like something out of Indiana Jones. Built into the rock, the church is all arches, naves, columns and even some frescoes. The main nave even has a mezzanine floor that looks over it.
Also within the complex are several other caves including the main dormitories and the school. All the rooms, including the cathedral are connected by secret passages and pitch-black tunnels. I was like a kid in a candy store.
In the most inner reaches of the complex, a group of girls have climbed up into an ascending tunnel, the man-made steps eroded to the point where climbing up the tunnel was a bit
Decorative Arches
More stylish and intricate arches inside the Selime Monastery - inside a CAVE.
of a challenge. The tunnel leads up into a small space which provides access to a steep tunnel that takes you all the way to the top of the mountain - like a chimney of sorts. I chat to the girls and it turns out that they're fellow Kiwis. It also turns out that we were not supposed to have climbed up into this small cave and are certainly not supposed to climb up the chimney.
I am mighty tempted, but the steps that take you up the chimney are in an even worse state than the initial steps that got us up here. With a bit of care, it was definitely do-able to get to the top - but with no hand rails to speak of, any slip on the way up would result in a ten metre tumble down what is effectively a laundry chute made of rock. It was enough for me to pass up the opportunity, but it didn't put off one of the Japanese guys on my tour who climbed all the way to the top! Legend. So much for Turkish health and safety - I have absolutely no doubt that Sag would have had
Hole In The Roof
The Selime Monastery has been around a while so you can only expect it to be naturally damaged in places. Makes for a cool sight though.
a go, were he here.
The tunnel wasn't the only dangerous feature of the monastery - there are natural holes in a lot of the caves and you had to be careful not to fall through them.
I loved it - there were tunnels and alternative routes to just about every place in the monastery - it was a shame we didn't have another half hour or so to muck around here.
The place had magnificent views across the landscape as well - a landscape that was used in the recent Star Wars films to depict planets in galaxies far, far away...
It had been a long day, so we were over it by the time we got the next stop - a local jewellery factory.
We were treated to air-conditioning and a demo of how they make jewellery and artefacts from the local turquoise. We also now know how to spot fake turquoise from the real thing.
It was obviously an arrangement to try and get us to buy jewellery from the rather large showroom, much like how tours and taxis take you to Egyptian perfumeries in Giza but there was no way any of us was going to buy anything. They didn't have
Pigeon Valley
Quite nice for place known for the collection of pigeon shit.
a bald, camp Egyptian man selling it for a start.
Just over the road from the jewellery factory was a view over Pigeon Valley, full of little holes in the hills used to collect pigeon shit for fertiliser back in the day.
And with this, the tour was brought to an end.
We had traditional Cappadocian testi kebabs for dinner that night at a rooftop restaurant overlooking Goreme.
Testi kebabs are cooked in a sealed clay pot which you then crack open with a small machete at your table. The testi was tasty and was certainly a novelty, as were the crunchy bits of clay pot fragments that you would accidentally eat with it.
After a long day that started at 5am that morning, it is no surprise we hit the sack straight after dinner.
After a late start the next day, we went to the Goreme Open Air museum where we bumped into Luis Figo giving another tour to another group of tourists. The outdoor museum is basically a collection of fairy chimneys that were lived in as houses and prayed in as churches. Having seen the Selime Monastery the previous day however, the fairy chimneys here
Apple Church, Goreme Open Air Museum
Illegally taken picture of the fabulous fresco inside the Apple Church.
were comparably unremarkable. Plus there was an incessant amount of tourists which meant queues to get into some of the caves including the Apple Church, which admittedly contained some of the most vivid, intact, and impressive frescoes of all the churches we had seen in Cappadocia.
We were pretty much over it.
On the way back into town we had a pleasant outdoor lunch at a cave cafe near the museum where I had some 'manti' or Turkish ravioli - small beef-filled dumplings smothered in yoghurt and paprika. It was nice, although I probably wouldn't order it again.
I also had some Turkish ice cream, which is less creamy than normal ice cream, and sweeter and more sticky. Still yum though. Doesn't need to be that cold as a result as well, which is just as well in a place like Turkey.
There are a lot of adventure excursions available in Goreme and while horse riding took the girls' fancy, Davies and I were fuelled by the desire to ride quad bikes.
We end up hiring a couple of quads from a family-run business, and we were taken on a 'tour' of the Goreme Valley by one of the
Quad Biking With A View
Davies takes some time out from crashing his quad bike to capture the scenery.
owner's sons, who was no older than 12.
Snaking through the network of quad tracks that criss-crosses the valley was certainly fun - even more so when you're surrounded by the most fascinating rock formations that you've ever seen, rock formations that look like penises.
The kid guiding us had the restless energy and the puerile humour of a er, kid, and demonstrated as much when taking pictures of two turtles having sex on the side of a track (yeah, we were taking pictures too) and taking Davies quad a for a few jumps while we stopped to take pictures. He certainly had some skillz with the bikes although you expect to do so if you ride them around all day every day. Perhaps he should get into motocross when he gets older.
The dirt on some of the tracks was quite loose and and braking the bike on such a surface caused you to slide uncontrollably rather than stop in some places. There was one particular turn that I just could not master and ended up sliding off the track and crashing the bike on its side the first time, and then getting stuck in the mud the second
Penis Stone
It just does, doesn't it?
time. As skilled as the boy was, it was still a bit embarrassing having a 12-yr old get your bike out of trouble.
I wasn't the only one falling off my bike however - an attempted slide by Davies ended up with him bailing off the bike, snapping a wing mirror and cracking the chassis in the process. This isn't the first time - Davies has previous with this kinda shit.
During the tour, we stopped by at yet more cave churches - the sheer number of them is quite amazing, and exploring them is them is quite fun. As we emerged from one, we see some familiar figures pass by on horseback - Claire and Penelope's tour following the same trails we were.
To end the tour, the kid takes us to a large clearing complete with a couple of steep ramps for kicks, and leaves us to our own devices while he rides off and mucks around with a huge group of his mates, all on either quads, scooters or motorbikes. With a whole gang of bikes charging around in a massive group it looked like a scene out of Mad Max.
If Davies wasn't hurt by his fall off the bike, then he
Inside Another Cave Church
These churches are everywhere and the decorative carvings inside them were amazing given how long ago these churches were carved out.
was certainly hurt by the amount he had to pay for the damage to his quad. Having inspected the damage, the kid's dad was pretty open and honest about what Davies had to pay - he showed Davies the website from which they ordered replacement parts for the bike so that Davies could see how much each part cost and he did not pay any more than the cost of the replacement part. Still, I can think of better ways to spend £90...
After the girls had their shopping fix - with Penelope buying a couple of plates and Rebecca buying a couple of lanterns as souvenirs - we decided to treat ourselves that night and ate at the fanciest looking restaurant in town.
Starting with the longest piece of bread ever I ordered the Cappadocian kofte with cheese, and it was delicious. And since it was our last night in Turkey Claire and I finally treated ourselves to our first glass of wine of the trip. The trip had been so full-on that we didn't really have the energy to go out at night and with all the boozing we do in London, it was nice having an
Balloons Over Cappadocia
The view was worth getting up for.
10-day alcohol break.
Which brings us to the end of the trip.
From the hustle and bustle of Istanbul, to the serenity of Gallipoli, to the history of Ephesus and Termessos, and the outlandish sights of Pamukkale and Cappadocia, Turkey has a lot going for it. And this is even before mentioning the beautiful beaches along the Mediterranean which we didn't get to. The food is amazing too - I will miss the grilled meats and ayran.
The most surprising thing about Turkey however, was the friendliness, hospitality and humour of the people. Most people from the the guys working on the buses, in the hotels, to the waiters and shopkeepers, everyone was warm, relaxed and happy to share a joke.
After my experiences of Muslim countries, particularly in Egypt and Morocco, it was easy to apply generalisations to Muslim people and Muslim countries. Whether Turkey is different because of its greater liberalisation and acceptance of western culture I don't know; but it is easy to draw that conclusion. I was pleasantly surprised.
In the meantime there is no rest for wicked - I will spend one night in London after getting back from Turkey before flying out
Rows Of Cave Buildings
At the Goreme Open Air Museum.
to San Francisco, a place quite different to Turkey. I'm certainly clocking up the miles.
As always, you will hear all about it right here.
Why the hell am I going almost straight from Turkey to San Francisco? You'll need to read the next entry to find out. Until then...
Gule Gule,
Comment	Subscribe	Follow (25)	Message
[blog=728697] [blogger=40820]
Brief history of Turkey
Modern Turkey was founded in 1923 from the Anatolian remnants of the defeated Ottoman Empire by national hero Mustafa KEMAL, who was later honored with the title Ataturk, or "Father of the Turks." Under his authoritarian leadership, the country adopt...more history
June 17th 2007 -» October 31st 2007
November 1st 2007 -» December 31st 2014
January 15th 2015 -» January 28th 2015
April 14th 2015 -» June 6th 2015
UK 2015
June 7th 2015 -» July 5th 2015
Excursions From Barcelona 2015
July 6th 2015 -» September 26th 2015
Latin America 2015-2016
September 27th 2015 -» May 30th 2016
May 31st 2016 -» November 12th 2016
Asia 2016-2017
November 13th 2016 -» November 22nd 2017
Excursions From Berlin
January 27th 2018 -» ongoing
Blog Poster
Blogger of the Week
With suspension bridge, mosque and er, Venetian gondola.
Inside a Turkish bathhouse.
Balloons Over Goreme
Looking over the town we were staying in from our balloon.
Caves!
A monastery of caves built into the rock - awesome.
The nave of the cathedral with a mezzanine level looking down on it. In a CAVE.
The different caves of the monastery are all linked by tunnels like this.
Testi Kebab
The waiter breaks open Claire's testi kebab.
Turkish kids rev up their bikes in the desert a la Mad Max.
Anastasia78
What an adventure!
And the photos are awesome!
Tot: 0.25s; Tpl: 0.077s; cc: 11; qc: 29; dbt: 0.0172s; 1; m:saturn w:www (104.131.125.221); sld: 1; ; mem: 1.3mb
Contact Derek Seto (Delek Delek) - a lack of a response does not mean that you have permission to use material from this page.


When most people hear the phrase "martial arts", they usually think of the Eastern martial arts such as Karate or Tae Kwon Do, but almost every culture has a martial arts legacy. The martial arts of Medieval Europe have been preserved in texts and manuscripts of the period. Come learn how modern students are rejuvenating these arts. Check out our reproduction practice swords and find out how you can train in the knightly arts.
When: Sunday, November 15, 7:45pm.


text:
Differential immunodominance hierarchy of CD8+ T-cell responses in HLA-B*27:05- and -B*27:02-mediated control of HIV-1 infection
Emily Adland, Matilda Hill, Nora Lavandier, Anna Csala, Anne Edwards, Fabian Chen, Marek Radkowski, Justyna D. Kowalska, Dimitrios Paraskevis, Angelos Hatzakis, Humberto Valenzuela-Ponce, Katja Pfafferott, Ian Williams, Pierre Pellegrino, Persephone Borrow, Masahiko Mori, Jürgen Rockstroh, Julia G. Prado, Beatriz Mothe, Judith Dalmau
Javier Martinez-Picado, Gareth Tudor-Williams, John Frater, Anette Stryhn, Soren Buus, Gustavo Reyes Teran, Simon Mallal, Mina John, Susan Buchbinder, Gregory Kirk, Jeffrey Martin, Nelson Michael, Jacques Fellay, Steve Deeks, Bruce Walker, Santiago Avila-Rios, David Cole, Christian Brander, Mary Carrington, Philip Goulder
© 2018 American Society for Microbiology. The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05- restricted CD8+ T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. We studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely related HLA-B*27:02 on the HIV-specific CD8+ T-cell response hierarchy and on immune control of HIV. Genetic epidemiological data indicate that both HLA-B*27:02 and HLA-B*27:05 are associated with slower disease progression and lower viral loads. The effect of HLA-B*27:02 appeared to be consistently stronger than that of HLAB* 27:05. In contrast to HLA-B*27:05, the immunodominant HIV-specific HLA-B*27:02- restricted CD8+ T-cell response is to a Nef epitope (residues 142 to 150 [VW9]), with Pol KY9 subdominant and Gag KK10 further subdominant. This selection was driven by structural differences in the F pocket, mediated by a polymorphism between these two HLA alleles at position 81. Analysis of autologous virus sequences showed that in HLA-B*27:02-positive subjects, all three of these CD8+ T-cell responses impose selection pressure on the virus, whereas in HLA-B*27:05-positive subjects, there is no Nef VW9-mediated selection pressure. These studies demonstrate that HLAB* 27:02 mediates protection against HIV disease progression that is at least as strong as or stronger than that mediated by HLA-B*27:05. In combination with the protective Gag KK10 and Pol KY9 CD8+ T-cell responses that dominate HIV-specific CD8+ T-cell activity in HLA-B*27:05-positive subjects, a Nef VW9-specific response is additionally present and immunodominant in HLA-B*27:02-positive subjects, mediated through a polymorphism at residue 81 in the F pocket, that contributes to selection pressure against HIV.
https://doi.org/10.1128/JVI.01685-17
CD8 T cell +
HIV Gag
HIV Nef
HLA-B*27
10.1128/JVI.01685-17
Fingerprint Dive into the research topics of 'Differential immunodominance hierarchy of CD8<sup>+</sup> T-cell responses in HLA-B*27:05- and -B*27:02-mediated control of HIV-1 infection'. Together they form a unique fingerprint.
HLA-B Antigens Medicine & Life Sciences
Human immunodeficiency virus 1 Agriculture & Biology
T-lymphocytes Agriculture & Biology
HIV Infections Medicine & Life Sciences
HIV-1 Medicine & Life Sciences
disease course Agriculture & Biology
infection Agriculture & Biology
Adland, E., Hill, M., Lavandier, N., Csala, A., Edwards, A., Chen, F., Radkowski, M., Kowalska, J. D., Paraskevis, D., Hatzakis, A., Valenzuela-Ponce, H., Pfafferott, K., Williams, I., Pellegrino, P., Borrow, P., Mori, M., Rockstroh, J., Prado, J. G., Mothe, B., ... Goulder, P. (2018). Differential immunodominance hierarchy of CD8+ T-cell responses in HLA-B*27:05- and -B*27:02-mediated control of HIV-1 infection. Journal of Virology, 92(4), [e01685-17]. https://doi.org/10.1128/JVI.01685-17
Adland, Emily ; Hill, Matilda ; Lavandier, Nora ; Csala, Anna ; Edwards, Anne ; Chen, Fabian ; Radkowski, Marek ; Kowalska, Justyna D. ; Paraskevis, Dimitrios ; Hatzakis, Angelos ; Valenzuela-Ponce, Humberto ; Pfafferott, Katja ; Williams, Ian ; Pellegrino, Pierre ; Borrow, Persephone ; Mori, Masahiko ; Rockstroh, Jürgen ; Prado, Julia G. ; Mothe, Beatriz ; Dalmau, Judith ; Martinez-Picado, Javier ; Tudor-Williams, Gareth ; Frater, John ; Stryhn, Anette ; Buus, Soren ; Teran, Gustavo Reyes ; Mallal, Simon ; John, Mina ; Buchbinder, Susan ; Kirk, Gregory ; Martin, Jeffrey ; Michael, Nelson ; Fellay, Jacques ; Deeks, Steve ; Walker, Bruce ; Avila-Rios, Santiago ; Cole, David ; Brander, Christian ; Carrington, Mary ; Goulder, Philip. / Differential immunodominance hierarchy of CD8+ T-cell responses in HLA-B*27:05- and -B*27:02-mediated control of HIV-1 infection. In: Journal of Virology. 2018 ; Vol. 92, No. 4.
@article{19b33bc1fd8c4477aa745858f68672e8,
title = "Differential immunodominance hierarchy of CD8+ T-cell responses in HLA-B*27:05- and -B*27:02-mediated control of HIV-1 infection",
abstract = "{\textcopyright} 2018 American Society for Microbiology. The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05- restricted CD8+ T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. We studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely related HLA-B*27:02 on the HIV-specific CD8+ T-cell response hierarchy and on immune control of HIV. Genetic epidemiological data indicate that both HLA-B*27:02 and HLA-B*27:05 are associated with slower disease progression and lower viral loads. The effect of HLA-B*27:02 appeared to be consistently stronger than that of HLAB* 27:05. In contrast to HLA-B*27:05, the immunodominant HIV-specific HLA-B*27:02- restricted CD8+ T-cell response is to a Nef epitope (residues 142 to 150 [VW9]), with Pol KY9 subdominant and Gag KK10 further subdominant. This selection was driven by structural differences in the F pocket, mediated by a polymorphism between these two HLA alleles at position 81. Analysis of autologous virus sequences showed that in HLA-B*27:02-positive subjects, all three of these CD8+ T-cell responses impose selection pressure on the virus, whereas in HLA-B*27:05-positive subjects, there is no Nef VW9-mediated selection pressure. These studies demonstrate that HLAB* 27:02 mediates protection against HIV disease progression that is at least as strong as or stronger than that mediated by HLA-B*27:05. In combination with the protective Gag KK10 and Pol KY9 CD8+ T-cell responses that dominate HIV-specific CD8+ T-cell activity in HLA-B*27:05-positive subjects, a Nef VW9-specific response is additionally present and immunodominant in HLA-B*27:02-positive subjects, mediated through a polymorphism at residue 81 in the F pocket, that contributes to selection pressure against HIV.",
keywords = "CD8 T cell +, HIV Gag, HIV Nef, HLA, HLA-B*27, Human immunodeficiency virus",
author = "Emily Adland and Matilda Hill and Nora Lavandier and Anna Csala and Anne Edwards and Fabian Chen and Marek Radkowski and Kowalska, {Justyna D.} and Dimitrios Paraskevis and Angelos Hatzakis and Humberto Valenzuela-Ponce and Katja Pfafferott and Ian Williams and Pierre Pellegrino and Persephone Borrow and Masahiko Mori and J{\"u}rgen Rockstroh and Prado, {Julia G.} and Beatriz Mothe and Judith Dalmau and Javier Martinez-Picado and Gareth Tudor-Williams and John Frater and Anette Stryhn and Soren Buus and Teran, {Gustavo Reyes} and Simon Mallal and Mina John and Susan Buchbinder and Gregory Kirk and Jeffrey Martin and Nelson Michael and Jacques Fellay and Steve Deeks and Bruce Walker and Santiago Avila-Rios and David Cole and Christian Brander and Mary Carrington and Philip Goulder",
doi = "10.1128/JVI.01685-17",
journal = "Journal of Virology",
Adland, E, Hill, M, Lavandier, N, Csala, A, Edwards, A, Chen, F, Radkowski, M, Kowalska, JD, Paraskevis, D, Hatzakis, A, Valenzuela-Ponce, H, Pfafferott, K, Williams, I, Pellegrino, P, Borrow, P, Mori, M, Rockstroh, J, Prado, JG, Mothe, B, Dalmau, J, Martinez-Picado, J, Tudor-Williams, G, Frater, J, Stryhn, A, Buus, S, Teran, GR, Mallal, S, John, M, Buchbinder, S, Kirk, G, Martin, J, Michael, N, Fellay, J, Deeks, S, Walker, B, Avila-Rios, S, Cole, D, Brander, C, Carrington, M & Goulder, P 2018, 'Differential immunodominance hierarchy of CD8+ T-cell responses in HLA-B*27:05- and -B*27:02-mediated control of HIV-1 infection', Journal of Virology, vol. 92, no. 4, e01685-17. https://doi.org/10.1128/JVI.01685-17
Differential immunodominance hierarchy of CD8+ T-cell responses in HLA-B*27:05- and -B*27:02-mediated control of HIV-1 infection. / Adland, Emily; Hill, Matilda; Lavandier, Nora; Csala, Anna; Edwards, Anne; Chen, Fabian; Radkowski, Marek; Kowalska, Justyna D.; Paraskevis, Dimitrios; Hatzakis, Angelos; Valenzuela-Ponce, Humberto; Pfafferott, Katja; Williams, Ian; Pellegrino, Pierre; Borrow, Persephone; Mori, Masahiko; Rockstroh, Jürgen; Prado, Julia G.; Mothe, Beatriz; Dalmau, Judith; Martinez-Picado, Javier; Tudor-Williams, Gareth; Frater, John; Stryhn, Anette; Buus, Soren; Teran, Gustavo Reyes; Mallal, Simon; John, Mina; Buchbinder, Susan; Kirk, Gregory; Martin, Jeffrey; Michael, Nelson; Fellay, Jacques; Deeks, Steve; Walker, Bruce; Avila-Rios, Santiago; Cole, David; Brander, Christian; Carrington, Mary; Goulder, Philip.
In: Journal of Virology, Vol. 92, No. 4, e01685-17, 01.02.2018.
T1 - Differential immunodominance hierarchy of CD8+ T-cell responses in HLA-B*27:05- and -B*27:02-mediated control of HIV-1 infection
AU - Adland, Emily
AU - Hill, Matilda
AU - Lavandier, Nora
AU - Csala, Anna
AU - Edwards, Anne
AU - Chen, Fabian
AU - Radkowski, Marek
AU - Kowalska, Justyna D.
AU - Paraskevis, Dimitrios
AU - Hatzakis, Angelos
AU - Valenzuela-Ponce, Humberto
AU - Pfafferott, Katja
AU - Williams, Ian
AU - Pellegrino, Pierre
AU - Borrow, Persephone
AU - Mori, Masahiko
AU - Rockstroh, Jürgen
AU - Prado, Julia G.
AU - Mothe, Beatriz
AU - Dalmau, Judith
AU - Martinez-Picado, Javier
AU - Tudor-Williams, Gareth
AU - Frater, John
AU - Stryhn, Anette
AU - Buus, Soren
AU - Teran, Gustavo Reyes
AU - Mallal, Simon
AU - John, Mina
AU - Buchbinder, Susan
AU - Kirk, Gregory
AU - Martin, Jeffrey
AU - Michael, Nelson
AU - Fellay, Jacques
AU - Deeks, Steve
AU - Walker, Bruce
AU - Avila-Rios, Santiago
AU - Cole, David
AU - Brander, Christian
AU - Carrington, Mary
AU - Goulder, Philip
N2 - © 2018 American Society for Microbiology. The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05- restricted CD8+ T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. We studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely related HLA-B*27:02 on the HIV-specific CD8+ T-cell response hierarchy and on immune control of HIV. Genetic epidemiological data indicate that both HLA-B*27:02 and HLA-B*27:05 are associated with slower disease progression and lower viral loads. The effect of HLA-B*27:02 appeared to be consistently stronger than that of HLAB* 27:05. In contrast to HLA-B*27:05, the immunodominant HIV-specific HLA-B*27:02- restricted CD8+ T-cell response is to a Nef epitope (residues 142 to 150 [VW9]), with Pol KY9 subdominant and Gag KK10 further subdominant. This selection was driven by structural differences in the F pocket, mediated by a polymorphism between these two HLA alleles at position 81. Analysis of autologous virus sequences showed that in HLA-B*27:02-positive subjects, all three of these CD8+ T-cell responses impose selection pressure on the virus, whereas in HLA-B*27:05-positive subjects, there is no Nef VW9-mediated selection pressure. These studies demonstrate that HLAB* 27:02 mediates protection against HIV disease progression that is at least as strong as or stronger than that mediated by HLA-B*27:05. In combination with the protective Gag KK10 and Pol KY9 CD8+ T-cell responses that dominate HIV-specific CD8+ T-cell activity in HLA-B*27:05-positive subjects, a Nef VW9-specific response is additionally present and immunodominant in HLA-B*27:02-positive subjects, mediated through a polymorphism at residue 81 in the F pocket, that contributes to selection pressure against HIV.
AB - © 2018 American Society for Microbiology. The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05- restricted CD8+ T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. We studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely related HLA-B*27:02 on the HIV-specific CD8+ T-cell response hierarchy and on immune control of HIV. Genetic epidemiological data indicate that both HLA-B*27:02 and HLA-B*27:05 are associated with slower disease progression and lower viral loads. The effect of HLA-B*27:02 appeared to be consistently stronger than that of HLAB* 27:05. In contrast to HLA-B*27:05, the immunodominant HIV-specific HLA-B*27:02- restricted CD8+ T-cell response is to a Nef epitope (residues 142 to 150 [VW9]), with Pol KY9 subdominant and Gag KK10 further subdominant. This selection was driven by structural differences in the F pocket, mediated by a polymorphism between these two HLA alleles at position 81. Analysis of autologous virus sequences showed that in HLA-B*27:02-positive subjects, all three of these CD8+ T-cell responses impose selection pressure on the virus, whereas in HLA-B*27:05-positive subjects, there is no Nef VW9-mediated selection pressure. These studies demonstrate that HLAB* 27:02 mediates protection against HIV disease progression that is at least as strong as or stronger than that mediated by HLA-B*27:05. In combination with the protective Gag KK10 and Pol KY9 CD8+ T-cell responses that dominate HIV-specific CD8+ T-cell activity in HLA-B*27:05-positive subjects, a Nef VW9-specific response is additionally present and immunodominant in HLA-B*27:02-positive subjects, mediated through a polymorphism at residue 81 in the F pocket, that contributes to selection pressure against HIV.
KW - CD8 T cell +
KW - HIV Gag
KW - HIV Nef
KW - HLA
KW - HLA-B27
KW - Human immunodeficiency virus
U2 - 10.1128/JVI.01685-17
DO - 10.1128/JVI.01685-17
JO - Journal of Virology
JF - Journal of Virology
M1 - e01685-17
Adland E, Hill M, Lavandier N, Csala A, Edwards A, Chen F et al. Differential immunodominance hierarchy of CD8+ T-cell responses in HLA-B*27:05- and -B*27:02-mediated control of HIV-1 infection. Journal of Virology. 2018 Feb 1;92(4). e01685-17. https://doi.org/10.1128/JVI.01685-17

redpajama_set_name: RedPajamaCommonCrawl


Our monthly TTE Reading Group is coming up on July 6, 2019.
In this online Reading Group we are discussing Maitreya's wonderful text called, The Supreme Continuity, or The Uttaratantrashastra, and are looking forward to welcoming all Tara's Triple Excellence participants to join us no matter in which part of the program you currently are. This will not be a teaching situation, rather it will be a discussion group to which we all contribute by sharing passages of the scheduled chapter(s) or asking questions.
The internet address of the Zoom room where we will gather online on Saturday morning, March 2nd is http://zoom.us/j/2943528030. Just click on this link and you will be taken to the Zoom session. Alternatively, you can write down the Zoom number and enter it manually in the space provided when you open your Zoom app.
The first session will start at: 10:00 a.m. CET (Vienna) Saturday July 6.
The second session will start at: 11:00 a.m. EST (New York) Saturday July 6.
We are planning to continue to meet on the first Saturday of each month, so the following meeting date should be August 3, 2019.
Don't have an account yet? Click here to create one for free!


Supplements won't make or break your fitness program, but the right ones and the right time can give you an extra boost. Don't know which ones might work for you? That's where JackedPack comes in. This supplement subscription service sends you sample packs so you can try it out before you commit.
Not available outside the U.S.
JackedPack is a monthly subscription box for weightlifters, bodybuilders, and fitness enthusiasts that ships you a sample-sized pack of various vitamins and supplements, allowing you to sample products from a wide-range of companies, before you commit to buying.
While supplements are not going to make or break and fitness program, using the right ones at the right time can help give your program that little extra boost. This way you don't need to stare at the avalanche of bottles on the shelves at your local nutrition store or scour the internet for clues on what might work for you. This way you can try for yourself without emptying your pockets and experimenting with supplements that might not work for your goals. JackedPack takes the long-term commit -- and the headache -- out of finding what works best for you.
JackedPack tailors boxes specifically to your fitness needs and flavor preferences.
Best for guys that are willing to try supplements to find what works best for them.
Packs include 5-10 samples to try.
New sign ups receive double sample with their first pack.
Shipping is free and ships between the 13th and 16th of each month.
JackedPack offers packs exclusively customized for men based on your goals.
My JackedPack came in a nicely branded, colorful red box. Upon opening it, I was surprised to find that it was packed with samples; more so than I thought it would be. I was surprised into that I went to their website to investigate and I noticed that in your first box, subscribers get double samples. So instead of the usual 6-8 samples that come in a box, I got 16; which is a nice way to intro a subscriber to JackedPack.
The first thing I did when I opened it was take out all of the samples. I'm not really sure what I was expecting exactly, but I wasn't blown-away, surprised, or impressed by anything in the box. Nothing struck me as really cool or awesome. They were just supplements. One feature of subscription boxes that I really like is when they provide you with info about the products; with product cards or some other method directly in the box. Don't make me go through an extra step of searching the website to find more info about a product I may be interested in.
Unfortunately, JackedPack did not have much in the way of product info cards. Granted, most of the products were pretty basic-level supplements, like pre-workout, and protein, but it's still a nice feature to include that gives more value to the subscriber.
The biggest upside to JackedPack is that, if you're a supplement junkie, or someone who is constantly looking for new supplements to try, then this subscription box for you. Where as other boxes, Like Gainz Box or WOD Box are a mixture of more than just purely supplements, JackedPack is all supplements, all the time.
In addition to the samples in the pack I received, JackedPack has partnered with over 70 different brands to deliver subscribers a large variety of samples, including companies like Optimum Nutrition, Cellucor, MuscleTech, BSN, MusclePharm, and others. Touted as a subscription box for weightlifters, bodybuilders, and fitness enthusiast, my JackedPack box came with a number of different samples, all aimed to help you improve your workout. There were a few different pre-workout and energy drink mixes, which I was happy to see. Having not taken any pre-workouts other than coffee for a long time, I knew my body would be very receptive to the stimulants contained in most pre-workouts.
I took the Labrada Super Charge pre-workout prior to my heavy lower body session. One of the nice things about this pre-workout supplement is that it didn't seem to give the skin-tingling jitters like a lot of other pre-workouts do. However, much to my surprise, I didn't notice anything vastly different in the quality or intensity of my workout. I use to take pre-workouts quite religiously to help get "jacked up" for my workouts. However, I've noticed that since I started consuming caffeine regularly prior to my workouts, that the pre-workout effect has been minimized quite a bit. So, while pre-workouts can give you a nice energy boost, as far as making your workouts that much better, I really don't see it.
The box also contained a number of post-workout amino acid mixes, aimed to help with muscle recovery. The purpose of these is to help fuel muscle protein synthesis, or, the body's ability to repair and grow muscle tissue. However, much like there are alternatives to expensive pre-workouts, the alternative to post-workout supplements is just a good diet.
One of the least surprising samples to find in the box were a few packets of protein powder. The best thing about protein powder is that it offers a quick and easy protein fix, without filling you up too much before or after a workout. I tried the Muscle Milk vanilla mix, and while the macros were good, the taste was mediocre at best.
As far as other supplements in the box, there was Focus Fury by Rebel Performance – which is aimed at increasing focus and cognitive function. These class of supplements – usually referred to as nootropics – can be hit or miss. I've taken some that really seemed to make a difference before, but Focus Fury did not seem to have the same effect.
There was also a "fat burning" supplement included, which was an immediate strike against JackedPack. Fat burning supplements do not work, and for one to be included in the box was very disappointing.
There were also a few non-supplement items. One was a tea mixture called SPORTea. Not being a tea-lover, this was really of no interest to me. Another was a cereal protein bar by one of my favorite company's, Quest. I've always been a big fan of their regular protein bars but never tried the cereal bars. I'm not really sure why, given that I like almost all of their products, but I didn't have high hopes for the cereal bar. Much to my surprise and delight, the waffle-flavor bar was very tasty, and had good consistency as well.
The other items in the box included a hand balm for rough hands and skin, and a Tiger Balm pain-relieving patch.
Like some other subscription boxes of this type, JackedPack allows you to review the supplements in your box. So you're able to go on their website, and check out what other people have said about the products in your box; which is nice. Unlike other subscription boxes however, JackedPack does not allow you to purchase full size products directly from their site; instead linking you out to external sites. So if you want to purchase multiple different products, this becomes a hassle, as you'll have to make multiple purchases, paying multiple different shipping fees.
JackedPack comes in three different subscription options: A monthly membership for $15.00 per month, a 6-month membership for $12.50 per month, and a yearly membership for $11.25 per month.
The nice thing about the way JackedPack has it's subscriptions set up is that if you opt for a 6-month subscription, you end up getting one of your boxes for free, and if you go with the yearly subscription, you end up getting three of your boxes for free.
Plus all subscription prices include shipping costs. However, there are two big downsides to the longer subscription options. First, you have to pay the entire cost of the 6-month or yearly subscription up front; which is $74.70 and $135.00, respectively. That's a lot to shell out up front for something you've never tried before. Second, while you can cancel anytime, after the first month you will not be refunded any money, and you'll continue receiving boxes until your subscription runs out. So, basically, anytime after month one, if you decided JackedPack isn't worth the money, too bad, you're out of luck.
JackedPack is pretty easy to subscribe to. The nicest thing about their subscription process is that there's a good amount of customization you can do. You can select your goals between "Muscle Gain" and "Fat Loss", as well as select which flavors of pre-workout, creatine, and protein powder you prefer. After that, you set up your account, select your subscription preferences, and you're good to go.
JackedPack's price of $15 (about $1 per sample) is a decent price for a monthly supplement box. And if you're willing to commit long-term, getting a few free boxes is a nice bonus. From the sample box I got – plus checking out the brands they have listed on their website – JackedPack gives you access to a number of high-quality products each month; so you're bound to find something you like.
And while not being able to cancel may make some people reluctant to commit long-term, if you're a weightlifter, bodybuilder, or fitness enthusiast looking for new supplements to try, JackedPack is a solid option.
We couldn't find any deals for JackedPack at this time.


Country Estates » Brambles Business Centre welcome Lillyfields Care Limited » Flexible offices and workspace.
Country Estates welcome Lillyfields Care Limited to their new office suite at 22/24 Brambles Business Centre, Hussar Court, Waterlooville, Hampshire.
Lillyfields Care Limited was set up nine years ago by Diane Jones and is a family run home care provider committed to supporting adults in the comfort of their own homes. For further information on the type of care and services Lillyfields provide visit their website here.
Lillyfields saw Brambles Business Centre as a convenient location, suiting their needs with the offices being connected through partitioning. They have taken on a one year lease.


text:
U.S. Presidential Election: Is Trump Or Clinton Better For Your Investments?
Roger Aitken Contributor
US Democratic presidential nominee Hillary Clinton greets supporters during a campaign rally at the... [+] Kent State University in Kent, Ohio, on October 31, 2016. (Photo Jewel Samad/AFP/Getty Images).
As the US prepares to choose a new President on November 8, passionate debate rages after three TV clashes between Hillary Clinton and Donald Trump. Now we have an FBI-email investigation to add to the mix. Whatever the outcome, change is coming and Americans need to act to shore-up their finances, if they haven't already.
One wonders if anyone knows anything about this election race or the outcome anymore. The polls had recently shown Clinton with a slight lead over Trump a couple of weeks ago. But polls have been wrong and ultimately the result in the end analysis may come down to turnout and how the as yet undecided vote.
It had been swinging around since just before the first televised presidential debate between the Republican and Democrat candidates running for the White House, when Clinton held a 9% lead going in.
Trump's campaign manager and strategist Kellyanne Conway managed to stabilize the ship in the aftermath. But by all accounts it's estimated that 12%-20% of voters back in September were labelled as undecided.
There is no time for complacency. For investors it's their worst enemy and with recent events this is no time to right off the Donald. In a major nationwide poll out today he edged ahead of Clinton by one percentage point in the ABC News/Washington Post tracking poll.
And, if Brexit teaches us anything it's that polling data is not gospel. Failing though for investors and savers to act sooner rather than later could result in missing out on important opportunities on the investing front and hitting some avoidable pitfalls.
US Election Effect
With the third US presidential debate now well behind us, markets are firmly focussed on the upcoming election. There have been some mixed results across currency and equity space.
The Mexican peso, for example, which has been something of a proxy trade against the perceived likelihood of a Trump win, reached a six-week high some 10 days ago. Its relative strength was linked to the market's firm belief then that Clinton was a shoo-in for the White House.
But matters can turn quickly as evidenced by the FBI's investigation into Clinton's emails, which jolted her campaign. Eleven days before the 2016 presidential election, James Comey, FBI Director, delivered an October surprise by announcing that the bureau had discovered additional emails and were reviewing them to gauge whether they were related to their investigation into Clinton's handling of classified information.
Gallery: Tips From 12 Money Experts On How To Invest This Election
Trump Moves Up As Volatility Returns
Now with just a week to go before the election, today's moves in the market reflect a pretty sizeable shift in sentiment and a realization that this presidential race is far from over. The latest ABC poll that gave Trump a slight lead over Clinton has been the catalyst for some fairly significant risk-off moves. Before the FBI news broke Clinton had a 2-point lead over Trump according to another ABC poll.
Neil Wilson, a senior markets analyst at broker ETX Capital in London, which is regulated by the UK's Financial Conduct Authority, commenting today said: "Our US election market is now giving Trump a roughly one in four chance of entering the White House - up from around one in eight just after the debates."
The VIX, the so-called 'gauge of fear' that measures US equity market volatility, has now jumped to 19. It had languished at around the 13-level mark for some time lately as markets thought Clinton was a shoo-in.
Wilson added: "The rise in volatility corresponds with a sell-off on the S&P 500, which has just broken some fairly important support levels to trade at its lowest level since July. Markets are clearly worried about a Trump win, or at investors are de-risking to protect against major shocks and volatility around the vote."
Given also the fact that the S&P 500 closed out October below its August 1 opening price is also being taken as "a strong signal that Trump should not be written off" according to Wilson.
Meanwhile, the Mexican peso, which is now the chief proxy trade for the US election, has dropped after the poll. It has extended losses after last week's FBI-email investigation bombshell rocked support for Clinton. The USD/MXN currency pair is trading handsomely above 19, which is a month low for the peso. Suffice to say we can expect further volatility over the coming week.
On the equity indices front, the S&P 500 was about 1% off a key metric two Thursdays ago. This says that the incumbent party (Democrats) would win if the index of US stocks climbs between the start of August and end of October. And, at that point the S&P 500 was effectively saying Trump will win. It all makes one think.
Who's Better For Your Investments?
Scott Tucker, a Chicago-based fiduciary investment advisor and founder of Scott Tucker Solutions Inc., commenting on who on balance - Trump or Clinton - would be better financially for Americans, says: "Different groups of Americans would benefit. Or, be harmed by either candidate and in different ways."
The advisor, who specializes in retirement and income planning and passed the necessary exam to become an investment adviser representative (IAR) with SEC-registered firm Wealth Financial Advisory Services, adds: "Trump would be better for families who are trying to pass assets to the next generation tax-free, as he'd end the estate ('death') tax. Hillary would be worse for these families, as she would increase estate taxes."
Tucker reveals that he recently met with a family this September, whose "estate taxes would double" under Hillary being elected.
"There are work-arounds to lessen the impact of estate taxes," Tucker points out. "One way is to work with a fiduciary advisor, to use specially-designed life insurance to pay the estate taxes."
Trump would seem to be better also for manufacturing workers, until one considers that his planned tariffs on imports would be greeted and met with "retaliation by other nations", and put American manufacturing workers at risk and out of work, as US exports would potentially be reduced in volume.
Hillary is seen by Wall Street as "more of the same" says Tucker - the 'status quo' candidate, and would largely keep-on with President Obama's policies.
The Stockmarkets
US stockmarkets would be "least affected" by a Hillary Clinton victory according to the Chicago advisor. "Both US and international stock markets would be shocked by a Trump win, and would react badly, at least at first, due to concerns over his planned tariffs on imported goods," he added.
Think here of a 'Brexit' type of shock. But if Trump wins, one can expect volatility for the US equities markets – and even for international stock markets.
Trump is viewed as tremendously beneficial for real estate developers, because he is one. "Trump would create another trillion-dollars in tax-breaks for real estate developers over the next 10 years," Tucker says. That said, Trump would harm companies dependent upon importing and exporting: Apple, General Motors, etc.
Meanwhile, Hillary is seen as beneficial for companies that are currently having an easy time of things. "She is just more of the same and not expected to rock many boats," Tucker posits.
Retirement Options?
As regards sensible investments for those coming up to retirement and things to consider in the forthcoming change in President, Tucker notes that what he sees most is people who have "only invested in stocks and bonds within their 401(k) plans and have no truly safe money."
He says: "Bonds are not truly safe. So, more bonds would not be something that I would advise. Safe money options would include things such as fixed-index annuities, which operate like a pension."
A downside though to fixed-index annuities is that they have early-withdrawal penalties, so it is prudent to consult with a fiduciary advisor before doing anything. And, it makes sense to some invest some - not all - of your money.
Generally speaking, an individual that is 50 years of age or older "should consider beginning to divest themselves, at least partially, of securities" according to Tucker.
As to which of the two candidates would enable you retire at the right age, Tucker ventures that Trump would be "disruptive to markets". So, one think Trump is going to win, then advises Tucker "you would hedge your bets…pulling some money out of the market."
That said, neither candidate is going to make all your retirement concerns disappear. Complacency should not be an option if you are serious about growing and protecting your wealth.
The best advice is to review your financial strategy to ensure the changes will be beneficial to your wealth. Investors should ensure that their portfolios are properly diversified and be aware of their tax liabilities and how they could change. But most importantly professional independent advice should be sought.
Tucker in Chicago argues: "Don't let the election hysteria drive your decisions. But do meet with a fiduciary advisor so you can get a handle on your investments and retirement planning."
The advisor regularly meets people who have one year to go before retirement. "That's not too late, but it's too late for me to do everything I could for them," he says. Ideally it makes sense he says to see "folks at least 10 years" before retirement.
Even if you are nowhere near retirement age, it's always better to plan now rather than to let life happen to you. This is especially pertinent given that America faces a looming retirement crisis in certain quarters and there are more changes expected in 2017 to social security. So don't put your head in the sands - whatever the outcome of the US presidential election after next Tuesday.
Roger Aitken
I am a freelance financial journalist based in London and former FT staff writer covering stock exchanges and transaction services. In recent years I have written for a ...


text:
Q: Pressing back button after navigating to an inner component closes Salesforce1 app in Android I am facing an issue where the app gets closed when back button is pressed after navigating to an inner component in all Android devices.
When back button is pressed after navigating to an inner component, the app gets closed, instead of navigating back to the previous component as is the case in iOS devices and in Desktop.
I've created an unmanaged package for easily replicating the issue.
Here's the link to install the package:- https://login.salesforce.com/packaging/installPackage.apexp?p0=04tB00000009ZWH

After installing, please go to Setup-->Salesforce1 Navigation and add
  Highcharts Demo to the menu items.

Steps to replicate:-

*

*Open Salesforce1 app in Android.

*Navigate to the inner component by clicking any of the point in the chart displayed.

*Press back button.

Result: The app gets closed
Expected: Navigate back to the previous component
PS:
Salesforce1, Version 13.0, Build number 30
| Android version 7.0

redpajama_set_name: RedPajamaStackExchange


Never get criticised for smelly feet ever again. These socks have permanent antimicrobial properties to reduce unpleasant odors thanks to the Meryl® Skinlife yarn with silver microparticles. The fabric keeps your feet dry and comfortable by moving moisture away from the skin. Designed for a superbly comfortable fit thanks to a body mapping construction.


text:
Baloch Journalist Goes Missing In Quetta City Since Nov 7
BalochistanImpunity 11/11/2014 - No comments
A Baloch journalist is reported missing from Balochistan's Quetta capital city since 7 November 2014 (Friday), his family confirms to Freedom Network [FN] on 11 November 2014.
"We don't know who may have taken him away," Imam Bukhsh Bugti, uncle of missing journalist Manzoor Ahmed Bugti, 24, who works for state-run Pakistan Television in Dera Bugti town, told FN, Pakistan's first media watchdog organization, by phone from Quetta.
Manzoor was on private visit to Quetta where he reached on 6 November 2014 and next morning at 10.30am he was reported missing along with friend Muhammad Aslam.
"You know it is Balochistan and if you come from Dera Bugti district then it is added problem," the uncle of the missing journalist said when asked whether Manzoor was under threat. "I would not say he received (direct) threats but was cautioned to be careful," he went on to add.
The uncle did not say who cautioned Manzoor.
"A case was registered in a police station in Quetta and I am using all my contacts to recover Manzoor," Imam said. He, however, did not elaborate.
Media is experiencing worse situation in Balochistan since a Baloch nationalists-led insurgency followed the killing of powerful chieftain and politican Nawab Akbar Bugti on 26 November 2007 during a "military operation" and both security forces and Baloch insurgent groups are held responsible for killing, intimidating, harassing, threatening and kidnapping journalists.
Manzoor is as old in journalism as four years and his father also practiced journalism.
No group has claimed responsibility for the journalist's disappearance so far.
Tags:Balochistan Media, Dera Bugti journalist goes missing, Pakistan Impunity And Media


Marriage: ABT 1482 of Utkinton, Cheshire, Eng.
Marriage: ABT 1484 of Utkinton, Cheshire, Eng.
Spouse: Middleton , Dafydd "Hen"
Marriage: ABT 1487 of Utkinton, Cheshire, Eng.
Marriage: ABT 1492 of Utkinton, Cheshire, Eng.
Marriage: ABT 1404 Of Ardrossan, Ayr., Scot.


Come see this piece of history in the City of Elmore. This home has a recently added metal roof. Home is being sold "AS IS" and is in need of many repairs. The home has had additions to the original structure.


text:
Applied Recognition's Face Biometrics Tech Reaches 0.2% CER
"The company says that its technology's advancement is the product of machine learning techniques, and that it will extend benefits to all of its SDKs and its entire Ver-ID line of applications."
Applied Recognition has reached a new benchmark in its facial recognition technology. The Toronto-based company says it has attained a 0.2 percent Cross-Over Error Rate (CER) in National Institute of Standards and Technology testing with the FERET dataset.
The CER refers to equanimity between an identification technology's False Acceptance Rate and its False Rejection Rate, which is "the best summary measure of face recognition technologies' efficacy," according to a statement from Applied Recognition. The company says that its technology's advancement is the product of machine learning techniques, and that it will extend benefits to all of its SDKs and its entire Ver-ID line of applications.
It could help the company to find new partners and clients as well, and Applied Recognition appears to be targeting the financial services industry in particular. In a statement announcing the new benchmark, Applied Recognition Co-CEO Ray Ganong said the technology's "new level of accuracy supports a completely automated workflow for financial transactions, such as opening a bank account or applying for a loan."
August 31, 2017 – by Alex Perala


Megyn Kelly Blackface Comment, Controversy And Apology. Here many shake their heads at this Blackface comment. Blackface to people of color has always been disrespectful, hurtful and not cute or funny. What do you think?


text:
Gujarat Assembly Polls: PM Modi Holds Massive Roadshow
Modi has been Gujarat's longest-serving chief minister from 2001 to 2014.
PM Modi Holds Massive Roadshow
Prime Minister Narendra Modi on Thursday held a massive roadshow in Ahmedabad in the run-up to the Gujarat Assembly elections.
People throng on both sides of the streets through which the Prime Minister's convoy was passing. People showered flowers on his convoy. The crowd carrying his posters were chanting "Modi...Modi.." The Prime Minister was also seen greeting people and waving his hands.
After a gap of two days, Prime Minister Modi once again returned to the Gujarat election campaign trail. His three-hour-long mega roadshow is spanning across 16 assembly constituencies for the second phase of the Assembly election.
Covering over 50 kms, the roadshow started from the Naroda Gam and will be ending at Gandhinagar South constituency. PM Modi is scheduled to make at least 35 stops at the memorials of prominent personalities including Pandit Deendayal Upadhyay, Sardar Vallabhbhai Patel and Netaji Subhas Chandra Bose on the way.
Thakkarbapanagar, Bapunagar, Nikol, Amraiwadi, Maninagar, Danilimbda, Jamalpur Khadia, Elisbridge, Vejalpur, Ghatlodia, Naranpur, Sabarmati are some of the constituencies that the Prime Minister is covering in his roadshow.
Interestingly, while the Prime Minister canvases for the second phase of the Gujarat election, the voting for the first phase of the Gujarat election was underway.
In the 2017 Gujarat polls, Bharatiya Janata Party's (BJP) tally stopped at 99 seats out of a total of 182 seats. The party has been in power for the last 27 years with Narendra Modi being the state's longest-serving chief minister.
This time, the party under the leadership of PM Modi, Amit Shah and CR Paatil is aiming at getting its highest seat tally exceeding 140.
The state has been a BJP stronghold for a long and the party has set its sights on returning to power for the seventh term.
Assam CM Reviews Three Projects With PWD Officials
Meanwhile, the voting for the first phase of the two-phased Gujarat Assembly polls concluded on Thursday at 5 pm with a total voter turnout of 56.75 per cent. The polling is taking place in 89 constituencies spread across 19 districts of Kutch, Saurashtra and South Gujarat.
BJP chief ministerial candidate Bhupendra Patel contested from the Ghatlodia seat. Among prominent candidates, Aam Aadmi Party (AAP) chief ministerial candidate Isudan Gadhvi contested from Khambhaliya, former Congress leader and BJP candidate Hardik Patel from Viramgam, former Congress leader and now BJP candidate Alpesh Thakor from Gandhinagar South.
AAP state president Gopal Italia contested from Katargam constituency, Gujarat Home Minister (State) Harsh Sanghavi from Majura, Rivaba Jadeja from Jamnagar North, former Gujarat minister Parshottam Solanki from Bhavnagar Rural, Kunwarji Bavaliya from Jasdan, Kantilal Amrutiya from Morbi and Jayesh Radadiya from Jetpur.
The second phase of the Gujarat election would be held on December 5.
The counting of votes will be done on December 8. Results of the Himachal Pradesh Assembly elections will also be declared on the same day.
(with inputs from ANI)
Victim Of DU Ragging Incident, Anand Sarma Undergoes Successful Surgery
PM Narendra Modi
Gujarat Assembly Polls


text:
Q: Retrieve json value in templates I have the following objects queried form a table after which the various objects are put In the following objarr.How to retrieve these values in UI in javascript
 from django.core.serializers import serialize
 json = serialize("json", objarr)
 logging.debug(type(json))
 response_dict.update({'objarr' : (json) })

 return HttpResponse(simplejson.dumps(response_dict), mimetype = 'application/javascript')

Logging.debug gives the following
   {'obj_arr': '[{"pk": 56, "model": "upload_info", "fields": {"emp_id": 13, "import_flag": 1, "resource": null, "feedback": "some feedabck", "hint": "test", "time": null, "created_by": 145, "access": 0, "keywords": "test1,test9", "type": 4, "error_flag": 0, }}, {"pk": 1156, "model": "upload_info", "fields": {"emp_id": 13, "import_flag": 1, "resource": null, "feedback": "some feedabck", "hint": "test", "time": null, "created_by": 145, "access": 0, "keywords": "test1,test9", "type": 4, "error_flag": 0, }}] }

In the UI i try to have to access the value of emp_id ,how do i do it
function retrieve_data(formid)
{
  var form = $(formid);
  form.ajaxSubmit({
  dataType:  'json',
  success:   function (data) {  //Data is the rendered oject of resposne_dict
  if((data)
  {
     alert(load_flag);
     How to print emp_id,error_flag and other details here
  }
  }
 } )   ;
}

A: You can also try below code to make that work:
String.prototype.toArr = function() {
    eval("var obj = " + this);
    return obj ? obj : [];
};
function retrieve_data(formid){
  var form = $(formid);
  form.ajaxSubmit({
   dataType: 'json',
   success: function (data) {
   if(data){
     data = data.toArr();
     alert(load_flag);
     alert(data['fields']["emp_id"]);
     // And likewise you can access all detail
   }
  }
 });
}

Hope this works for you.. :)

A: You need to download the json2.js file and add it to your application
In the response try this
if((data)
{
  var response=eval("("+JSON.stringify(data)+")");
  for(var i=0;i<esponse.obj_arr[0].fields;i++){
    var emp=  response.obj_arr[0].fields[i].emp_id
  }
}

You will get the value of emp_id in the variable emp..
Similarly do for others
response.obj_arr[0].fields[i].import_flag
response.obj_arr[0].fields[i].resource
response.obj_arr[0].fields[i].feedback

and assigning them in a variable...