text:
Short telomeres are a risk factor for idiopathic pulmonary fibrosis
Jonathan K. Alder, Julian Chen, Lisa Lancaster, Sonye Danoff, Shu Chih Su, Joy D. Cogan, Irma Vulto, Mingyi Xie, Xiaodong Qi, Rubin M. Tuder, John A. Phillips, Peter M. Lansdorp, James E. Loyd, Mary Y. Armanios
Biodesign Institute
Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their enigmatic etiology has complicated approaches to effective therapies. Idiopathic pulmonary fibrosis (IPF) is the most common of IIPs and shares with IIPs an increased incidence with age and unexplained scarring in the lung. Short telomeres limit tissue renewal capacity in the lung and germ-line mutations in telomerase components, hTERT and hTR, underlie inheritance in a subset of families with IPF. To examine the hypothesis that short telomeres contribute to disease risk in sporadic IIPs, we recruited patients who have no family history and examined telomere length in leukocytes and in alveolar cells. To screen for mutations, we sequenced hTERT and hTR. We also reviewed the cases for features of a telomere syndrome. IIP patients had shorter leukocyte telomeres than age-matched controls (P < 0.0001). In a subset (10%), IIP patients had telomere lengths below the first percentile for their age. Similar to familial cases with mutations, IPF patients had short telomeres in alveolar epithelial cells (P < 0.0001). Although telomerase mutations were rare, detected in 1 of 100 patients, we identified a cluster of individuals (3%) with IPF and cryptogenic liver cirrhosis, another feature of a telomere syndrome. Short telomeres are thus a signature in IIPs and likely play a role in their age-related onset. The clustering of cryptogenic liver cirrhosis with IPF suggests that the telomere shortening we identify has consequences and can contribute to what appears clinically as idiopathic progressive organ failure in the lung and the liver.
Dyskeratosis congenita
Liver fibrosis
Dive into the research topics of 'Short telomeres are a risk factor for idiopathic pulmonary fibrosis'. Together they form a unique fingerprint.
Idiopathic Pulmonary Fibrosis Medicine & Life Sciences 100%
Idiopathic Interstitial Pneumonias Medicine & Life Sciences 96%
Telomere Medicine & Life Sciences 91%
Cryptogenic Cirrhosis Medicine & Life Sciences 28%
Telomerase Medicine & Life Sciences 20%
Alveolar Epithelial Cells Medicine & Life Sciences 20%
Liver Cirrhosis Medicine & Life Sciences 17%
Alder, J. K., Chen, J., Lancaster, L., Danoff, S., Su, S. C., Cogan, J. D., Vulto, I., Xie, M., Qi, X., Tuder, R. M., Phillips, J. A., Lansdorp, P. M., Loyd, J. E., & Armanios, M. Y. (2008). Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proceedings of the National Academy of Sciences of the United States of America, 105(35), 13051-13056. https://doi.org/10.1073/pnas.0804280105
Short telomeres are a risk factor for idiopathic pulmonary fibrosis. / Alder, Jonathan K.; Chen, Julian; Lancaster, Lisa et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 35, 02.09.2008, p. 13051-13056.
Alder, JK, Chen, J, Lancaster, L, Danoff, S, Su, SC, Cogan, JD, Vulto, I, Xie, M, Qi, X, Tuder, RM, Phillips, JA, Lansdorp, PM, Loyd, JE & Armanios, MY 2008, 'Short telomeres are a risk factor for idiopathic pulmonary fibrosis', Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 35, pp. 13051-13056. https://doi.org/10.1073/pnas.0804280105
Alder JK, Chen J, Lancaster L, Danoff S, Su SC, Cogan JD et al. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 2008 Sep 2;105(35):13051-13056. doi: 10.1073/pnas.0804280105
Alder, Jonathan K. ; Chen, Julian ; Lancaster, Lisa et al. / Short telomeres are a risk factor for idiopathic pulmonary fibrosis. In: Proceedings of the National Academy of Sciences of the United States of America. 2008 ; Vol. 105, No. 35. pp. 13051-13056.
@article{0d80f1adac734a29b83d594f98529ae3,
title = "Short telomeres are a risk factor for idiopathic pulmonary fibrosis",
abstract = "Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their enigmatic etiology has complicated approaches to effective therapies. Idiopathic pulmonary fibrosis (IPF) is the most common of IIPs and shares with IIPs an increased incidence with age and unexplained scarring in the lung. Short telomeres limit tissue renewal capacity in the lung and germ-line mutations in telomerase components, hTERT and hTR, underlie inheritance in a subset of families with IPF. To examine the hypothesis that short telomeres contribute to disease risk in sporadic IIPs, we recruited patients who have no family history and examined telomere length in leukocytes and in alveolar cells. To screen for mutations, we sequenced hTERT and hTR. We also reviewed the cases for features of a telomere syndrome. IIP patients had shorter leukocyte telomeres than age-matched controls (P < 0.0001). In a subset (10%), IIP patients had telomere lengths below the first percentile for their age. Similar to familial cases with mutations, IPF patients had short telomeres in alveolar epithelial cells (P < 0.0001). Although telomerase mutations were rare, detected in 1 of 100 patients, we identified a cluster of individuals (3%) with IPF and cryptogenic liver cirrhosis, another feature of a telomere syndrome. Short telomeres are thus a signature in IIPs and likely play a role in their age-related onset. The clustering of cryptogenic liver cirrhosis with IPF suggests that the telomere shortening we identify has consequences and can contribute to what appears clinically as idiopathic progressive organ failure in the lung and the liver.",
keywords = "Aplastic anemia, Dyskeratosis congenita, Interstitial lung disease, Liver fibrosis, Telomerase",
author = "Alder, {Jonathan K.} and Julian Chen and Lisa Lancaster and Sonye Danoff and Su, {Shu Chih} and Cogan, {Joy D.} and Irma Vulto and Mingyi Xie and Xiaodong Qi and Tuder, {Rubin M.} and Phillips, {John A.} and Lansdorp, {Peter M.} and Loyd, {James E.} and Armanios, {Mary Y.}",
T1 - Short telomeres are a risk factor for idiopathic pulmonary fibrosis
AU - Alder, Jonathan K.
AU - Chen, Julian
AU - Lancaster, Lisa
AU - Danoff, Sonye
AU - Su, Shu Chih
AU - Cogan, Joy D.
AU - Vulto, Irma
AU - Xie, Mingyi
AU - Qi, Xiaodong
AU - Tuder, Rubin M.
AU - Phillips, John A.
AU - Lansdorp, Peter M.
AU - Loyd, James E.
AU - Armanios, Mary Y.
N2 - Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their enigmatic etiology has complicated approaches to effective therapies. Idiopathic pulmonary fibrosis (IPF) is the most common of IIPs and shares with IIPs an increased incidence with age and unexplained scarring in the lung. Short telomeres limit tissue renewal capacity in the lung and germ-line mutations in telomerase components, hTERT and hTR, underlie inheritance in a subset of families with IPF. To examine the hypothesis that short telomeres contribute to disease risk in sporadic IIPs, we recruited patients who have no family history and examined telomere length in leukocytes and in alveolar cells. To screen for mutations, we sequenced hTERT and hTR. We also reviewed the cases for features of a telomere syndrome. IIP patients had shorter leukocyte telomeres than age-matched controls (P < 0.0001). In a subset (10%), IIP patients had telomere lengths below the first percentile for their age. Similar to familial cases with mutations, IPF patients had short telomeres in alveolar epithelial cells (P < 0.0001). Although telomerase mutations were rare, detected in 1 of 100 patients, we identified a cluster of individuals (3%) with IPF and cryptogenic liver cirrhosis, another feature of a telomere syndrome. Short telomeres are thus a signature in IIPs and likely play a role in their age-related onset. The clustering of cryptogenic liver cirrhosis with IPF suggests that the telomere shortening we identify has consequences and can contribute to what appears clinically as idiopathic progressive organ failure in the lung and the liver.
AB - Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their enigmatic etiology has complicated approaches to effective therapies. Idiopathic pulmonary fibrosis (IPF) is the most common of IIPs and shares with IIPs an increased incidence with age and unexplained scarring in the lung. Short telomeres limit tissue renewal capacity in the lung and germ-line mutations in telomerase components, hTERT and hTR, underlie inheritance in a subset of families with IPF. To examine the hypothesis that short telomeres contribute to disease risk in sporadic IIPs, we recruited patients who have no family history and examined telomere length in leukocytes and in alveolar cells. To screen for mutations, we sequenced hTERT and hTR. We also reviewed the cases for features of a telomere syndrome. IIP patients had shorter leukocyte telomeres than age-matched controls (P < 0.0001). In a subset (10%), IIP patients had telomere lengths below the first percentile for their age. Similar to familial cases with mutations, IPF patients had short telomeres in alveolar epithelial cells (P < 0.0001). Although telomerase mutations were rare, detected in 1 of 100 patients, we identified a cluster of individuals (3%) with IPF and cryptogenic liver cirrhosis, another feature of a telomere syndrome. Short telomeres are thus a signature in IIPs and likely play a role in their age-related onset. The clustering of cryptogenic liver cirrhosis with IPF suggests that the telomere shortening we identify has consequences and can contribute to what appears clinically as idiopathic progressive organ failure in the lung and the liver.
KW - Aplastic anemia
KW - Dyskeratosis congenita
KW - Interstitial lung disease
KW - Liver fibrosis
KW - Telomerase


Previous message: [TimorLesteStudies] Book review by Anthony Goldstone of "The History of Peacebuilding in East Timor"
political economic implications of the evolving international system.
She is co-editor of The Political Economy Reader: Markets as Institutions and co-author of Rents to Riches? The Political Economy of Natural Resource-Led Development.


text:
Disturbing, Gore, Horror, Movie Reviews, Slasher
Hostel Part II (2007)
November 28, 2020 Kisha 1 Comment
Director: Eli Roth
Starring:Lauren German, Roger Bart, Heather Matarazzo, Bijou Phillips, Richard Burgi, Jay Hernandez, Edwige Fenech . USA/Slovakia/Iceland. 1h 34m
After the success of his 2005 slaherific body horror gore fest Hostel, Eli Roth returns with arguably much of the same but with a trio of girls at the helm of a hellride in Europe. There are some cute nods to the colourful survivors from the previous movie however I feel that Roth only gives us the same level of gore as before, rather than taking the film to higher levels of stomach churning buckets of blood, he plays it off with an intelligent and considered movie which expands the Hostile "universe" before it's all shat down the pan in the third and final movie (to date).
Opening with a Paranoid Paxton (Hernandez) in a small cameo, as he attempts to hide out with his girlfriend in a secluded summerhome. He's clearly suffering from PTSD, he lives on edge, filled with pills for his nerves and migraines as he attempts to keep an eye out for a follow up after his violent escape from a secret cult hidden deep in Europe.
After a touch of decapitation the film steps away from the familiar face of Paxton to a trio of charming American students decide to swing by Slovakia on their way home, Beth, Whitney, and Lorna, are convinced by Axelle, a nude model they are sketching, to join her on a luxurious spa vacation. On turning up to the Hostel we see another familiar face behind the counter. It's these familairites that got fans so excited for the sequel, in fact a copy of the movie made it online and was shared through p2p so much it won the title of the most pirated movie to date, which possibly had a lot to do with its failings in the box office. So by now and still in the opening of the movie anyone who saw the original knows what's coming next, so what surprises does the film hold?
Initially we see a bit more of the set up of how the auctions are set up. In a world where the rich elite can pay a secret group to kidnap random people for them to live out their sadistic fantasies, locking these unfortunates in dungeons to be tortured and killed is second nature now. The twist comes when a patreon wants to kill his wife, but he obviously can't do that so his brother puts a hefty bid on a girl who looks just like his sister in law, we realise just how far and wide reaching the killer cult really is. While Beth is a target, there is no limit on also taking her companions with her, after all no witnesses is the best policy.
While the girls attempt to fit in and enjoy the autumn festival season, Beth at least notices a few strange going on's she's not just a pretty rich girl, she have a sharp eye and isn't balled over by pretty trinkets of smiling mysterious strangers, her street smarts and keen eye keeps the pace of the film going otherwise it would have been over in minutes with the ditziness of her travelling companions. Between markets and cider filled festivals with frivolous traditional music and dancing, the little gang of children re appear wreaking havoc now and again, but they have a bigger role to play as their connection and fear of the "group" is more evident.
Obviously the kills are what really drew in the audience, there's another range of sick individuals who have crazy fantasies to play out, most notable is a woman who thinks herself as a reincarnation of Ezerbret Bathory, together with her scythe and bathtub she has a desire for blood and knows how to make her victim bleed. There was some criticism for the amount of nudity in the first movie, and while Eli didn't shy away fully there's still a decent amount of nudity (not all female) but he had to edge around the censors with CGI nipples!? It's hard to believe how censorship really affects movies but alas this is how politics affects cinema, so think about that the next time you vote!
The story incorporates the original movie, some of the cast and lots of the ideals, while it doesn't double the fun it does remain a similar vein and is really strong in how to make a decent sequel, but without going beyond to give the audience more, but just some of the same it does let itself down, however I do feel that it wasn't because the director wasn't willing and able to but just restricted by censorship. Highly anticipated by stars as much as fans, Edwige Fenech, Ruggero Deodato, Daniel Frisch, Gabriel Roth all make cameos, Tarintino wanted to but has to make do with Pulp Fiction playing on a TV in the background.
A strong, valuable movie which doesn't quite live up to expectations but had all the formula of a great Part II and a cracking little ending that made a few men squirm, a touch of feminism? Why not!?
Hostel 2 (2007) Blood thirsty sequel that lives up to the same rep as the original. The girls gone wild version of Hostel has buckets of blood, gore, secret societies and creepy hostel workers as a group of Americans are brought by the rich to be tortured and killed. pic.twitter.com/05eDxM2z1L
— Admit 1 Film Addict (@admitonefilmadd) November 28, 2020
R: Hostel (2005), Train (2009), The Collector (2009)#
L: 10 Torture Horrors Vol 1
5s: Eli Roth, Edwige Fenech,
2007bloodchainschick flickgirlsgoregutshicelandslovakiatortureusa
Previous PostFeed the Devil (2015)Next PostShort Movie Roundup 29 November 2020
One thought on "Hostel Part II (2007)"
johnrieber says:
I actually enjoyed his "Cannibal Holocaust" homage, "The Green Inferno" more, partly because these "capture and torture" films seem a bit predictable to me…still, he's a pretty effective Director!

redpajama_set_name: RedPajamaCommonCrawl


text:
do we become more ourselves in late life — or not necessarily so?
Posted on September 1, 2010 by Ashton Applewhite
Conventional wisdom holds that we become "more" who we are — virtues, vices and all — in old age. Swedish sociologist Lars Tornstam, who's been studying the aging process for over 25 years, has observed a very different phenomenon. "The mistake we make in middle age is thinking that good aging means continuing to be the way we were at 50. Maybe it's not," Tornstam told the Paula Span in The New Old Age blog.
Instead he sees many older people who continue to mature socially and psychologically, in ways that may surprise or even dismay. Hallmarks of this process, which Tornstam calls gerotranscendence, include less fear of death and disease, an increased desire for solitude, and diminished commitment to old habits, routines and principles. (There's a full list in the two-page pamphlet on Dr. Tornstam's website – link on bottom right corner – which makes very interesting reading.)
If a mom's wanderlust fades or an uncle quits his bowling league, we're likely to wring our hands and blame illness or depression. But such transitions may reflect greater self-esteem, more spontaneity, or a need for time to reflect on larger questions: what Tornstam describes in his Theory of Gerotranscendence as "a shift in meta perspective, from a materialistic and rational view of the world to a more cosmic and transcendent one, normally accompanied by an increase in life satisfaction." More undergirding for that U-shaped happiness curve I keep encountering.
The withdrawal aspect sounds a lot like the Disengagement Theory that emerged in the 1960s and viewed aging as a natural and beneficial process of pulling away from society. Much criticized, this theory has been supplanted by that of "successful" or "productive" aging, which is characterized by maintaining social relationships and working to maintain physical and cognitive health. I've been very much on that bus (search for "successful aging" on this blog), though troubled by the inference that those who chose to age differently (not to mention those without a choice) were perceived as less valuable. I'm making my way towards a viewpoint that can encompass both ends of the spectrum, and I thank Tornstam for shining some light on the path.
formerly "Formerly"
Jane's confused and so are we.
One thought on "do we become more ourselves in late life — or not necessarily so?"
Sharon Gary says:
Ashton,
Thanks for your thoughts on Dr. Tornstam's work. I too am of the mindset that successful aging means staying engaged.
Having worked in homecare in NYC throughout the '90's, I encountered too many people who had withdrawn from the world and became afraid of going outside. Were they agoraphobic? This withdrawal into solitude all too often meant becoming socially isolated, and it was often accompanied by mental illness — agoraphobia, depression and paranoia being the top three. All of this while health problems mounted. Often, I and the health care team were their primary, or only, human contact.
My hunch was that many people had begun disengaging from the world years earlier — in their 30's or 40's — and it wasn't a pretty picture. I observed that those who stayed interested in others, who had social contacts outside of the family and who stayed active to the best of their ability seemed to fare the best. And, they were the standouts within this home care context.
One was an 86-year old retired social worker, widowed, who was a painter. She had a 94-year old boyfriend, who wanted to live with her; she didn't want that. They had lunch together every afternoon. She went to the New School every week for painting classes.
Another was a retired Martha Graham dancer, who lived in the East Village. Her husband had died the year before and she was struggling emotionally. Her health had taken a dive after his death. She was having a hard time even walking around her home safely. Still, she had former students who stopped by regularly to visit and help her out. She wanted to know all about my romantic life. Come to think of it, she gave me good advice, which I didn't listen to, of course. She was engaged.
Another was a widow, who lived alone in a Mitchell-Lama building off of 1st Avenue. Once she was able to return to going back out to the park to visit her friends, she was a different person. She smiled more, talked more and was eager to get out to visit her friends. She also complained that her 40-year old son, who faithfully called her or visited her every week, wasn't doing enough for her. That's another story.
Thanks for posting.


text:
using Quartz.Impl;
using Quartz.Job;
using Quartz.Simpl;
using Xunit;

namespace Quartz.DynamoDB.Tests.Integration.JobStore
{
    /// <summary>
    /// Contains tests related to the Addition of Jobs and Job Groups.
    /// </summary>
    public class JobAddTests : JobStoreIntegrationTest
    {
        public JobAddTests()
        {
            _testFactory = new DynamoClientFactory();
            _sut = _testFactory.CreateTestJobStore();
            var signaler = new Quartz.DynamoDB.Tests.Integration.RamJobStoreTests.SampleSignaler();
            var loadHelper = new SimpleTypeLoadHelper();

            _sut.Initialize(loadHelper, signaler);
        }

        /// <summary>
        /// Tests that when CheckExists is called for a job that exists, it returns true.
        /// </summary>
        [Fact]
        [Trait("Category", "Integration")]
        public void CheckExistsWhenJobExsits()
        {
            JobDetailImpl detail = TestJobFactory.CreateTestJob();
            _sut.StoreJob(detail, false);

            bool result = _sut.CheckExists(detail.Key);
            Assert.True(result);
        }

        /// <summary>
        /// Tests that after storing a new job, that job can be retrieved
        /// with the same name, group and type.
        /// </summary>
        [Fact]
        [Trait("Category", "Integration")]
        public void StoreNewJob()
        {
            JobDetailImpl detail = TestJobFactory.CreateTestJob();
            _sut.StoreJob(detail, false);

            var result = _sut.RetrieveJob(new JobKey(detail.Name, detail.Group));

            Assert.NotNull(result);
            Assert.Equal(detail.Name, result.Key.Name);
            Assert.Equal(detail.Group, result.Key.Group);
            Assert.Equal(typeof(NoOpJob), result.JobType);
        }

        /// <summary>
        /// Tests that after storing an exsting job, that job is updated if the replaceExisting param is passed as true.
        /// </summary>
        [Fact]
        [Trait("Category", "Integration")]
        public void StoreExistingJobOverwrite()
        {
            JobDetailImpl detail = TestJobFactory.CreateTestJob();
            detail.Description = "Original";

            _sut.StoreJob(detail, false);

            detail.Description = "Updated";
            _sut.StoreJob(detail, true);

            var result = _sut.RetrieveJob(new JobKey(detail.Name, detail.Group));

            Assert.Equal("Updated", result.Description);
        }

        /// <summary>
        /// Tests that after storing an exsting job, an exception is thrown if that job is updated and the replaceExisting param is passed as False.
        /// </summary>
        [Fact]
        [Trait("Category", "Integration")]
        public void StoreExistingJobDontOverwriteThrows()
        {
            JobDetailImpl detail = TestJobFactory.CreateTestJob();
            _sut.StoreJob(detail, false);

            Assert.Throws<ObjectAlreadyExistsException>(() => _sut.StoreJob(detail, false));
        }
    }
}

redpajama_set_name: RedPajamaGithub


Based in Barcelona, Iberital is redefining the espresso machines industry by creating a new high-end segment beyond the "hipster-era".
Iberital, a family-owned SME based in Barcelona, wanted to make history in the food industry. The company started as a pure metalworking and spare parts manufacturer but Blai Farré—Iberital's founder—soon set his sights on a much larger game: the espresso machine manufacturing industry.
Forty years after setting the goal, Iberital is changing the industry's mindset towards a new era of sophistication, where technological excellence and the finest aesthetics meet.
- To create a new high-end territory in which efficiency, technology and health would become the key drivers.
- To position the brand as a premium range manufacturer.
We collaborated with Iberital, Andreu Carulla from ACID studio and other brand stakeholders to build disruptive positioning for VISION, Iberital's new Hero Product.
Based on the brand's roots, its attitude towards innovation, proven commitment towards the environment and cutting-edge technology developed in-house, we came up with a great story that sowed the seed for naming the espresso machine, its new identity, tone of voice, and communication messages.
For its launch, Iberital has been touring VISION in Europe and Asia using the modular structures we have designed to spread the message. Iberital's stands and parties have been a hit in the industry!
In order to simultaneously upgrade Iberital's perception around the globe, we have engaged Iberital's distributors in the process, giving them the appropriate resources to spread the word.
Iberital's content strategy mixes owned, earned and paid media. Everything stemmed from a specialized content hub that was created to gain experts' credibility. After its success online, we thought about creating a limited printed edition as a gift for the brand's core audience. This tool has proven to be so successful that we have expanded the editions further as a marketing tool to enter new markets and reach new clientele.
The Coffee Universe was born in 2015. It's Iberital online magazine with a limited print run. A content hub where we periodically publish articles, interviews and curiosities from the coffee universe.


Charlotte Dating Over 40 - Don't Miss Out on True Love.
We're a totally free dating site in Charlotte.
... Personals & Singles in Charlotte, North Carolina - 100% Free.
... We're 100% free for everything, meet Charlotte singles today.Chat with singles on our free Charlotte dating site.
Pre-Dating Charlotte Speed Dating Singles Events - Monthly Parties in Charlotte.
make dating in Charlotte easy! Plentyoffish is 100% Free, unlike paid dating sites.
week, we have a vast selection of single men and single women for you to date!


text:
Q: RabbitMQ Exchange and Queue are not created automatically
I have created a new spring application which will push messages to a rabbitmq server.
My rabbitMQConfig java file looks like this :
@Configuration
public class RabbitMQConfig {

    private static final Logger LOGGER = LoggerFactory.getLogger(RabbitMQConfig.class);

    @Value("${spring.rabbitmq.host}")
    private String SPRING_RABBITMQ_HOST;

    @Value("${spring.rabbitmq.port}")
    private int SPRING_RABBITMQ_PORT;

    @Value("${spring.rabbitmq.username}")
    private String SPRING_RABBITMQ_USERNAME;

    @Value("${spring.rabbitmq.password}")
    private String SPRING_RABBITMQ_PASSWORD;

    @Bean
    public RabbitTemplate rabbitTemplate(){
        CachingConnectionFactory connectionFactory = new CachingConnectionFactory(SPRING_RABBITMQ_HOST,SPRING_RABBITMQ_PORT);
        connectionFactory.setUsername(SPRING_RABBITMQ_USERNAME);
        connectionFactory.setPassword(SPRING_RABBITMQ_PASSWORD);
        RabbitTemplate rabbitTemplate = new RabbitTemplate(connectionFactory);
        rabbitTemplate.setExchange("my.controller.exchange");
        rabbitTemplate.setRoutingKey("my.controller.key");
        return rabbitTemplate;
    }

    @Bean
    DirectExchange exchange() {
            return new DirectExchange("my.controller.exchange", true, false);
    }

    @Bean
    public Queue queue() {
            return new Queue("my.controller", true);
    }

    @Bean
    Binding exchangeBinding(DirectExchange exchange, Queue queue) {
            return BindingBuilder.bind(queue).to(exchange).with("my.controller.key");
    }
}

Here is how I push message to the queue :
@Service
public class RabbitPublisher {

    @Autowired
    private RabbitTemplate rabbitTemplate;

    private static Logger LOGGER = Logger.getLogger(RabbitPublisher.class);

    public  Boolean  pushToMyQueue(HashMap<String, Object> message) {
        try {
            rabbitTemplate.convertAndSend("my.controller.exchange","my.controller.key",message);
            return true;
        } catch (Exception e) {
            e.printStackTrace();
            LOGGER.error("Error in pushing to my queue", e);
        }
        return false;
    }
}

Since the exchange and queue are non-existent on the rabbitmq server, I expect them to be created automatically and message to be pushed. But it results in the following error :
ERROR 18198 --- [168.201.18:5672] o.s.a.r.c.CachingConnectionFactory       :
Channel shutdown: channel error; protocol method: #method<channel.close>
(reply-code=404, reply-text=NOT_FOUND - no exchange
'my.controller.exchange' in vhost '/', class-id=60, method-id=40)

When I create the exchange and queue and bind them manually on the server, a message gets pushed successfully.
Please let me know if I am missing something. Thanks.

A: You need to add a RabbitAdmin @Bean. The admin will declare the elements when a connection is first opened.

A: You have to add AmqpAdmin admin bean with your required connection factory as below:
   @Bean(name = "pimAmqpAdmin")
    public AmqpAdmin pimAmqpAdmin(@Qualifier("defaultConnectionFactory") ConnectionFactory connectionFactory) {
        return new RabbitAdmin(connectionFactory);
    }

redpajama_set_name: RedPajamaStackExchange


WebScout has 92 business centers and office buildings currently available across various locations in Barcelona, ready for you to move in and get to work. The office suites and cowork spaces we offer throughout the city allow you do business in a prime central location. WebScout offers full service office space without the high overheads and long-term commitments of traditional commercial real estate leases.
Whether you need to be located in the heart of Barcelona, the famous Gothic Quarter, Plaza Catalunya, Gran Via De Les Corts Catalanes, or the surrounding areas - you will be spoiled for choice with our extensive range of office listings in and around these sought-after locations.
Our aim at Webscout is to help your business find and secure the most appropriate furnished office in Barcelona, arrange a rental agreement that works for you, and get you into your new Barcelona business premises as quickly as possible.
There is a wide variety of quality office space on offer, from conventional leased space to temporary workspace, from coworking space for freelancers and startups to large private office space and everything in between. We will be happy to help you navigate the various options and choose the solution that is best suited for your business. Whether you are a social entrepreneur, a team of software engineers or independent professionals, a social media marketer or digital nomad, or other - central Barcelona is a great place to begin your journey, or accelerate your success.
Much of the coworking and private office space in Barcelona comes inclusive of an outstanding array of support services, with manned receptions, day pass options, building security and professional IT support ideal of software engineers, 3D printers for the digital nomad, high speed internet connections and WiFi - which is perfect for social media agencies.
A number of the executive centers offer tenants video conferencing services, events workshops/event space for the social entrepreneur, boardrooms, kitchens, and some are even located within close proximity to essential transport links. You will be spoiled for choice when searching for your new space in Barcelona!
Just choose from the private office space and coworking space currently on offer that you'll find displayed above. The Barcelona coworking space and serviced office space for rent currently available on this site is found in some of the best company locations and is currently available for rent on temporary agreements, giving you the opportunity to secure furnished office space for the length of time you want.
Coworking in Barcelona is very popular, so it is a great place for independent professionals and likeminded people. Those looking for quality office solutions in and around various locations in Barcelona should look no further than WebScout!
Need help with your private or shared office space search? Why not get in touch with us using the inquiry form or phone number above and we'll be happy to help you locate private suites or coworking space in Barcelona. Whether you require a space located in the heart of Barcelona, or the outskirts - we will do our best to help you find the right space.


text:
Contact Us Now: 303-781-0322
Plog & Stein P.C. Home
Contact Plog & Stein P.C.
Family Law Practice
Maintenance (Alimony)
Stephen J. Plog
Laura B. Stein
Sarah T. McCain
Jessica Saldin
Michelle L. Searcy
Johanna E. Blumenthal
James C. McTurnan
Sherry A. Westerman
303-781-0322 Exceptional Solutions For Reasonable Rates
Douglas County, Colorado
Divorce and Custody Attorneys in Douglas County, Colorado
At Plog & Stein, P.C., our Douglas County divorce attorneys have focused their practice exclusively on custody and divorce cases since 2001. Our track record of long-term client satisfaction demonstrates our ability to achieve the best resolution possible for our clients and their children, while making a difficult process easier. For years, Douglas County has been recognized as one of the wealthiest counties in the country from a median income standpoint. The attorneys at Plog & Stein are well versed in dealing with complex divorce and custody cases, including litigating cases involving high income and significant assets.
Family law cases affect people from all socioeconomic groups and every walk of life. They can be grueling and emotional matters, with lasting ramifications affecting both adults and children. They touch on the most sensitive and private aspects of people's lives. Moreover, the repercussions of these cases can be felt for years.
Under these circumstances it is critical to find a divorce attorney in Douglas County whom you trust, and who possesses significant knowledge and experience dealing with domestic relations legal issues.
Plog & Stein, P.C. handles every aspect of domestic relations cases, including:
If you are interested in discussing your family law matter, schedule a consultation today. Why Retain Plog & Stein, P.C.?
If you are like most people dealing with a family law matter, you want to feel that your needs are being addressed by a lawyer who knows your case as well as you do, but who can voice the legal aspects of your perspective better than you can. You may be worried about the future and dreading the possibility of legal battles that lie down the road. Our office can help you alleviate your fears.
How do we approach family law cases?
We learn as much about the facts of your case as we can, so that we not only offer outstanding service in an immediate matter, but can also help in future legal matters as they arise.
Although the stress that all families feel under these circumstances can be similar, every family has different needs. We are attentive listeners who find out what you want, and give you an honest assessment of your case and how it is likely to be perceived by the court.
We will also give you a sense of the cost-benefit to any decision we ask you to make, and advise you on the most logical next steps in light of the bigger picture.
Our office is aware of the importance of being cost-conscious in economically difficult times. When it comes time to negotiate with the other side, we are ethical, firm, and mindful of the family's need for an amicable resolution. However, if matters cannot be resolved through an informal process, we are ready to go to court to protect the interests of you and your children. Our Douglas County divorce lawyers strive to build a long-term relationship of trust with our clients through hard work and great results. That's what we do.
Our In-Depth Experience in Douglas County Courts
Douglas County District Court is a part of the 18th Judicial District of Colorado. The county includes the cities of Castle Rock, Highlands Ranch, Littleton, Parker, and Lone Tree. We have represented clients from cities throughout the county and brought numerous matters before the judges of the Douglas County District Court. Our substantial experience gives us a firm understanding of the judicial and administrative processes of this area, and we work hard to pass along the benefits of our experience to our clients.
Call us, Today, at (303) 781-0322 to Speak With a Douglas County Divorce Lawyer for Free or to Schedule an In-Person Consultation.
If you are dealing with a difficult family law situation, it's important to have a family law firm on your side that you can trust. The caring and dedicated attorneys at Plog & Stein, P.C. can help you with your case. We offer cost-effective, practical solutions at competitive rates. Our South Metro office is conveniently located in Greenwood Village, near I-25 and Orchard.
Contact our office today by calling (303) 781-0322 to schedule a meeting with one of our family law lawyers.
Highlands Ranch Alimony Highlands Ranch Child Custody Highlands Ranch Child Support Highlands Ranch Child Support Modifications Highlands Ranch Divorce Highlands Ranch Family Law Highlands Ranch Property Division Highlands Ranch Emergency/Short Terms Representation Highlands Ranch Division of Retirement Accounts Highlands Ranch Modification of Custody Castle Rock Alimony Castle Rock Child Custody Castle Rock Child Support Castle Rock Divorce Attorney Castle Rock Parenting Time Parker Alimony Parker Child Custody Parker Child Support Parker Child Support Modification Parker Divorce Attorneys Parker Family Law Parker Legal Separation Parker Modification of Parenting Time Lone Tree, Colorado Douglas County Alimony Douglas County Child Custody Douglas County Family Law Douglas County Divorce Douglas County Child Support
Speak with a divorce attorney today
Parenting Time and Custody Modifications
Child Relocation
Complex Marital Estates
Emergency Hearings / Short Notice Representation
Premarital Agreements
Grandparent Rights
Visitation / Parenting Time
Family Law Appeals
Marriage Annulment
His passion and ferocity kept me going through this long ordeal.
When I first came to Plog & Stein it was simply discuss the renegotiation of child support. Little did I know that within 72 hours I would be retaining Steve Plog for a custody battle. His passion and ferocity kept me going through this long ordeal. I have recommended him to my friends and I would recommend him to anyone with who wants honest and effective representation. Carolyn
I recommend Sarah and the attorneys at Plog & Stein to anyone that has these types of family issues and need strong, knowledgeable representation.
I am thankful for the job Sarah McCain did for me in my fight with my ex-wife for visitation rights with my daughter. Sarah and the team at Plog & Stein handled my case in an efficient, affordable, and professional manner. Sarah negotiated a new parenting plan as well as acceptable visiting rights and even a favorable modification in my child support. I recommend Sarah and the attorneys at Plog & Stein to anyone that has these types of family issues and need strong, knowledgeable representation. Tom
At the end of the day he was able to produce a settlement that was fair to both parties.
I highly recommend Stephen Plog for anyone in need of a top notch domestic relations attorney. After a 27 year marriage, Stephen represented me in a complicated and sometimes bitter divorce with many unique challenges. At the end of the day he was able to produce a settlement that was fair to both parties but limited my alimony payments to only 3 years. He is smart, cuts to the chase, knows the court system in the Denver metropolitan area and can be trusted to get his clients the best possible settlement. Neal
Their service was outstanding, with prompt responses to all of my questions.
Sarah McCain and Plog & Stein were wonderful to me during such a difficult time in my life. Their service was outstanding, with prompt responses to all of my questions and creative ideas throughout the proceedings to help things go smoothly. Sarah's compassion, patience, and expertise were especially invaluable to me. I highly recommend them. Sandy
DTC Office
6021 S Syracuse Way,
North Denver Office
10901 W. 120th Ave.,
7900 E Union Ave.,
The information on this website is for general information purposes only. Nothing on this site should be taken as legal advice for any individual case or situation.
This information is not intended to create, and receipt or viewing does not constitute, an attorney-client relationship.
We serve clients throughout the State of Colorado including, but not limited to, those in the following localities: Denver County including Denver; Arapahoe County including Aurora, Centennial, Greenwood Village, and Littleton; Broomfield County; Douglas County including Highlands Ranch, Parker, Castle Rock, and Franktown; Jefferson County including Lakewood, Arvada, Wheat Ridge, and Golden; Adams County including Brighton, Westminster, Northglenn, and Thornton; Boulder County; Elbert County including Elizabeth and Kiowa; El Paso County; Weld County; Larimer County.
Douglas County, Colorado | Highlands Ranch Family Law Lawyers
Copyright © 2019, Plog & Stein P.C.


text:
Vinyl revival: why albums are on track to make CDs redundant
THE hottest format in music over the last year? Vinyl. A whole new generation is embracing vinyl albums over compact discs and streaming.
Cameron AdamsNational music writer
January 27, 2017 - 10:00PM
Vinyl replaced compact discs, but now it looks like vinyl revival is making the CD redundant
'Embarrassed': Bono's surprise U2 confession
Adele's insane Vegas earnings revealed
Group could miss out on festival funds
THERE is major 'back to the future' action happening in JB HiFi stores across Australia — and it's not in the DVD department.
Positioned prominently in the biggest music chain in Australia are not only racks full of newly-pressed vinyl albums, but an array of turntables to play them on.
The vinyl resurgence has outlived being a mere recycled fad with the format on track to outsell the format that replaced it — the compact disc.
For Melbourne store Polyester Records, vinyl sales now make up 90 per cent of their business; it was less than 20 per cent a decade ago when vinyl was considered all but extinct.
Polyester co-owner Nate Nott said the resurrection of vinyl can be linked to the disposable nature of modern formats like streaming and downloading and the short-attention span generation.
Polyester Records co owner Nate Nott says vinyl makes up 90 per cent of the store's business. Picture: Alex Coppel
"It's the process," Nott said.
"There are so many distractions now, we're always doing 1001 things. Listening to vinyl is something to do without your phone, it's something where you can stop and enjoy it and get rid of all the other distractions. It's the way vinyl lovers like to consume music. They will stream and download as well, but people who really pay attention to music like sitting on a couch and listening to a record."
Sales of vinyl have been on the comeback for the past decade. Last year vinyl sales worldwide were the highest they've been in 25 years.
In the UK last year, 3.2 million vinyl albums were sold. The Australian sales statistics will be released by ARIA later this month, but are expected to follow the upward trend after jumping 38 per cent from 2014 to 2015.
JB's embracing of vinyl speaks volumes; it's now easier to find a new vinyl album than a CD in the chain's busy stores.
You can now buy an entry-level turntable for $130 at JB, or splash up to $1000 on a state of the art model favoured by DJs.
Record labels, already haemorrhaging from the rapidly declining sales of CDs, are embracing music fans falling in love with vinyl again.
In the UK last Christmas, sales of vinyl hit $3.92 million, outpacing digital sales at $3.43 million. Vinyl sales doubled in 12 months while digital sales halved.
Polyester Records sells only a handful of compact discs these days. Picture: Alex Coppel
Vinyl is seen as a more personal, tangible and meaningful present than, say, an iTunes voucher.
This April will mark the 10th anniversary of Record Store Day, a day when music stores around the world are swamped by music lovers.
Major labels have jumped on the occasion, printing a slew of one-off, limited edition rarities; some independent record stores control such limited edition purchases to try and stop the products winding up selling for a small fortune on eBay.
The popularity of Record Store Day helps the remaining bricks and mortar record stores; outlets that have also suffered with the rise of the digital downloading (legally or illegally) of music.
The day has for some years now been Polyester's most profitable day of the year.
"It's a blessing, it's like a second Christmas for us," Nott said.
"It gets us through winter. We still stock CDs — I like CDs, there's no doubt they'll probably have a resurgence again too, but the amount of customers who want to buy them are few and far between. I'm not saying vinyl has picked up the slack of the loss of CD sales, but we're still here because it continues to grow every year."
Paul Rigby runs Zenith Records, Australia's only vinyl record pressing plant, based in East Brunswick.
The resurgence in vinyl led the company to upgrade to bigger premises three years ago, lugging their mid '70s vintage vinyl-making machinery with them, including a cutting lathe, which transfers the music into physical form.
Paul Rigby is the owner of Zenith Records, who had to expand to bigger premises to cope with demand
He's watched vinyl be discovered by a new generation, and now come full circle.
"The 18 to 30 year-olds discovered vinyl for the first time a few years ago, now that's gone mainstream," Rigby said. "You can buy a cheap turntable from JB and now a lot of older people are buying them, it's a bit of a nostalgic throwback to growing up with vinyl. You're also seeing kids buy mum and dad their favourite records. The top selling records for last year were mostly classic albums. There's a second wave of the original vinyl generation getting back into it and embracing it for sentimental reasons. We had the craft beer boom, now it's vinyl."
In the UK, last year's Top 5 selling albums on vinyl were David Bowie's Blackstar, Amy Winehouse's Back to Black, the Guardians of the Galaxy soundtrack, Radiohead's A Moon Shaped Pool and Fleetwood Mac's classic Rumours.
Vintage albums by The Stone Roses, Bob Marley, The Beatles, Prince and Nirvana rounded out the Top 10.
The biggest vinyl sellers in the US last year were Twenty One Pilot's Blurryface, Bowie's Blackstar, Adele's 25, plus Back to Black and A Moon Shaped Pool. America's 2016 Top 10 also included albums by Lana Del Rey and Miles Davis.
Australia doesn't have a similar list, but Polyester's biggest seller on vinyl last year was Nick Cave and the Bad Seeds' Skeleton Tree.
Some of Zenith Records' more colourful vinyl creations for artists including Urthboy and You Am I.
Rigby, who used to work in the CD industry, saw the format devalue itself rapidly.
"It wasn't long before CDs were being given away free with newspapers or magazines," he said. "People became accustomed to getting a CD for free. It lost its currency. Then downloading came in, people could get their music for free, even if it was illegal. CDs were never collectable like vinyl was. CDs never retained their value. People sought vinyl as a keepsake. Not long ago people were buying vinyl as a piece of merchandise, even if they didn't have a turntable. It was an item of desire.
"It's a classic object that holds a lot of mystique. Even second-hand collectable vinyl can be worth something. There is an inconvenience — you can't play vinyl in your car or while you jog. But it does tend to get looked after. A limited pressing or an Australian tour EP could be worth a lot of money. I look at collectors' sites online and see records we've pressed here selling for $600 and I think 'Geez, we should have held onto a few of those!' The whole vinyl collectors world is another world in itself."
The shock deaths of David Bowie and Prince last year resulted in hot demand for their vinyl back-catalogue, both new and second hand.
Their record labels were quick to press up CDs and vinyl to cope.
David Bowie is one of many artists who has limited edition releases issued for Record Store Day.
"It's about quickly getting in as many vinyl records as you can before they all get snapped up when something like that happens," Nott said.
"Which feels a bit creepy, but people want to buy them. These days there's rarely a record released that isn't also on vinyl, from Leonard Cohen to Ausmuteants. There isn't one act or genre that sells most — things go in waves. The Beck back catalogue has just been reissued on vinyl, so we're selling a lot of those at the moment."
The vinyl boom means pressing plants around the world are finding new work. The biggest plants, in the Czech Republic, France and the US, never shut, but more are popping up to cope with demand.
Zenith, which employs eight people, is now manufacturing new records for US labels. Rigby said punters have to accept the format is more costly than CDs and, obviously, downloads.
It's around $4000 to press up 500 records, with Zenith working on a six-to-eight week turnaround. They're trying to get that turnaround down to a month.
"Vinyl is an expensive process," Rigby said. "The actual compound to make the vinyl is expensive, the amount of compound you need to make a 12 inch record is nearly one dollar's worth of vinyl. Compare that to eight cents of polycarbonate plastic for a CD. It's not an innovative, cutting-edge product we're making. It's a throwback product. But it's passion that drives it."
Nott said the falling Australian dollar has driven the cost of albums (most of which are imported) up by around $10 or more.
Some new albums can be as much as $70, with most priced between $30 and $40 depending on where consumers shop.
Making vinyl at Zenith Records in Melbourne
"They're more expensive than we'd like them to be," Nott said. "But people treasure vinyl. Records aren't made in sweatshops. It's a precision process. It's a very human process and people understand these things cost money to make. If you look after a vinyl album you're going to have it for life."
Vinyl albums are also enjoying a second wind in second hand stores, providing a cheaper way to find the format.
"People often refer to the resurgence of vinyl as a fad but in the six years that we have been open the sale of vinyl has definitely been constant," said Matt Sigley, owner of Long Story Short in Kyneton.
"Like many people I've been collecting for years so vinyl has never been something that has come in and out of my life, it's always been there. There's definitely a younger generation of customer coming through who are looking for the 'classic' albums as well as those looking for more obscure or collectable albums. There will often be people who missed the CD age all together and who are going straight from MP3 to vinyl. We sell nearly four times as much vinyl as we do CDs. We sometimes even sell the odd cassette to someone who still has a tape player in their car."
Sigley said compact discs are now being dumped by gen Xers in op shops and second hand stores.
"It's happening at an astounding rate. People seem to attach no value to them anymore. It's the same thing that happened when mainstream vinyl was being phased out in the late '80s. A lot of people got rid of their collections and now they're trying to recollect them! I remember going into Brashs around 1989 and the vinyl section had been reduced to one box with about 20 LPs in it while the rest of the store had been taken over by CDs. Go into JB Hi Fi now and it's the opposite."
Vinyl fans are flocking to second hand stores.
Purple reign at Zenith Records.
Sigley said the most in-demand acts on preloved vinyl are the classics.
"The Beatles, Bowie and Pink Floyd are some of the most popular acts. I don't think people will ever stop buying their records. However one of our repeat sellers is Oxygène by Jean Michel Jarre. Every time we have it playing in the shop someone who's either never heard it or hasn't heard it for years asks to buy it straight off the turntable!"
Ironically, Sigley said there is now a market for CDs of albums by Australian bands of the '80s and '90s which have never been re-pressed and are seen as incredibly rare.
"They sell for way more than the vinyl. Not so long ago you would had to have paid over $100 for a copy of 1927's ... ish CD, as opposed to picking a vinyl copy up for $5 or $10. Even now a copy of Real Life's Heartland CD sells for $100 plus."
The Melbourne Record Club is now running a BYO Vinyl Night where punters can bring their favourite record at venues where they provide the turntable. You sign your name on a list and get a call up when it's time to spin your tracks and become a DIY DJ.
Leif van den Dungen has been running the clubs for several years.
"It's started to really take off," he said. "Now with vinyl sales and stores soaring punters have been liberating their records from their homes and sharing their favourite records with others."
Musician Ella Hooper, who acted as Record Store Day ambassador last year, grew up with vinyl in her DNA.
The vinyl-pressing equipment at Zenith Records dates back to the early to mid 1970s.
"Mum and dad had heaps of vinyl, so I always knew vinyl was special and that it was to be treated more carefully than CDs."
Hooper notes the love of vinyl goes deeper than the grooves.
"As much as vinyl does sound better and there is that collectability factor with records, there is also a real community of people who love hanging around in record stores. That's where they might meet up rather than a cafe or a pub. I get it, I'm a big record fondler. I love going to record stores, reading the sleeve, seeing who mastered the album or mixed it. That's something we've lost in the digital age that really frustrates me."
Record labels are taking advantage of the resurgence, pressing collector's editions of classic albums and hitting collectors where it hurts with expensive box sets.
Beatles/Paul McCartney obsessive Karen Freedman has never stopped buying vinyl, for both its collectability and sonic reasons.
"Vinyl does sound much better — as long as you have a decent sound system," she says. "It's more tangible. Record sleeves of old were often works of art. Sleeve notes and lyrics weren't designed to be read with a magnifying glass. Vinyl is preferable over CDs, however, CDs are still preferable over MP3s, or as I call it, air."
Her most expensive piece of vinyl is a first edition of McCartney's Снова в СССР, his Russian-only 1988 album.
"A Russian gentleman came into the London Virgin Megastore where I was working offering a brand new copy of the first edition, with the yellow back sleeve. He was asking for five hundred pounds. I'd already made a name for myself there as the 'Wacky Australian girl who loves Paul McCartney', so of course he was told to see me. I talked him down to £200. To put things into perspective, I was taking home £84 a week. Rent was £50.
"I went with him to an ATM around the corner where miraculously I had enough money in my bank account. I paid, he thanked me, gave me the precious platter and off he went. I think he had a bag full of them. Of course, a short while later, Paul's fan club most generously sent every member a free copy of the second release. I was lucky to meet Paul and got both signed by him. I think it was a fairly good investment."
The Beatles reissued all their albums on vinyl in a box set.
Turns out Bono is one of U2's toughest critics, offering some withering critiques of his own band in a recent interview.
She famously hates touring – so superstar Adele's upcoming Las Vegas residency is going to be worth her while.
A $43 million package to help music festivals survive the Omicron surge has been launched – but one group could miss out on the money.