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Movie Trailer Drops for THE HATE U GIVE Based on the #1 New York Times Best Selling Book by Angie Thomas
Posted by Bonnie @ A Backwards Story on June 25, 2018
Last night, the first full trailer for upcoming movie The Hate U Give dropped during the BET Awards. Less than 12 hours later, the trailer already has over 1.1 million views on YouTube. Fitting for what is hyped to be one of the most important movies of the year, especially considering the novel has spent the last 68 weeks on the New York Times Best Sellers List since it debuted last February--and many of those weeks have been spent at #1, where it is residing once more this week. THE HATE U GIVE is Angie Thomas' first novel and has already won or been shortlisted for several awards, including the prestigious National Book Aard Longlist, Michael L. Printz Award, William C. Morris Award, and Coretta Scott King Award. Her sophomore novel, ON THE COME UP, will release in February 2019.
THE HATE U GIVE stars Amandla Stenberg (Everything, Everything, The Darkest Minds, The Hunger Games) as Starr Carter, a teenager who witnesses a police officer shoot and kill her best friend, Khalil, played by Algee Smith (Detroit, The New Edition Story). Starr lives in a poor neighborhood, but attends a prep school with much wealthier classmates. Her two worlds collide with the shooting and help Starr find her voice and stand up for what she believes is right.
The movie is directed by George Tillman Jr. (Notorious, Men of Honor, The Longest Ride) and also stars K.J. Aha (Riverdale), Sabrina Carpenter (Girl Meets World, Sofia the First), Common (Wanted, The Suicide Squad), Regina Hall (Scary Movie, Black-ish), Russell Hornsby (Fences, Grimm), and Anthony Mackie (The Hurt Locker, several Marvel Avengers and Captain America movies as Falcon).
Check out the brand-new trailer
for THE HATE U GIVE,
out OCTOBER 19, 2018:
Here's a full summary for the novel THE HATE U GIVE:
Title: THE HATE U GIVE
Author: Angie Thomas
Release Date: Feb. 28, 2017
Publisher: Balzer + Bray // HarperCollins
Soon afterward, his death is a national headline. Some are calling him a thug, maybe even a drug dealer and a gangbanger. Protesters are taking to the streets in Khalil's name. Some cops and the local drug lord try to intimidate Starr and her family. What everyone wants to know is: what really went down that night? And the only person alive who can answer that is Starr.
But what Starr does or does not say could upend her community. It could also endanger her life.
movie news movies trailer


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Appraisal of anti-smoking advertising by youth at risk for regular smoking: a comparative study in the United States, Australia, and Britain
M Wakefield1,
R Durrant1,
Y Terry-McElrath2,
E Ruel3,
GI Balch3,
S Anderson4,
G Szczypka5,
S Emery5,
B Flay5
1The Cancer Council Victoria, Melbourne, Australia
2University of Michigan, USA
3University of Illinois, Chicago, USA
4University of Strathclyde, Scotland, UK
For correspondence:
M Wakefield, Director, Centre for Behavioural Research in Cancer, The Cancer Council Victoria, Carlton, Victoria, Australia, 3053;
Melanie.Wakefield{at}cancervic.org.au
Objective: To compare the similarity in how youth in the United States, Australia, and Britain appraise anti-smoking advertisements with different characteristics.
Design: Each participant viewed and evaluated a set of 10 anti-smoking adverts (from an overall total of 50 adverts) in a controlled experimental context using an audience response methodology. A structured telephone interview was completed one week after viewing the adverts, in which recall and engagement with the adverts by participants was evaluated.
Subjects: 615 youths who were experimenting with smoking or were susceptible nonsmokers.
Main outcome measures: Measures of advert appraisal and engagement.
Results: Youth in the United States, Australia, and Britain responded in very similar ways to the same anti-smoking advertisements. In full multivariate models, the target audience of the advert and the advert theme were not related to the main outcome measures employed in this study. However, adverts with visceral negative or personal testimonial executional characteristics were appraised more positively by youths and were more likely to be recalled, thought about, and discussed at follow up one week later.
Conclusions: Youths in three different countries responded to anti-smoking advertisements in very similar ways, suggesting that such adverts might be more actively shared among nations. The appraisal of, and engagement with, the anti-smoking adverts, however, varied substantially depending on executional characteristics. In the design of effective anti-smoking adverts, due attention needs to be paid to those characteristics that appear to most engage youth across different social and cultural environments.
http://dx.doi.org/10.1136/tc.12.suppl_2.ii82
A good deal of evidence now indicates that anti-smoking advertising can be effective in reducing levels of smoking among youth.1–5 Anti-smoking advertising has been a prominent component of tobacco control initiatives in the United States and has been associated with declines in smoking prevalence among both youth and adults in the States where such advertising has been employed.1,6,7 The use of anti-smoking advertising has also been an important element of tobacco control efforts in Australia since the early 1980s. These advertisements, which have most recently depicted in graphic detail the adverse health consequences of smoking, have generated high public awareness and positive responses among both youth and adults.8–11 Tobacco control programmes in Britain have also employed anti-smoking advertising with some success.12
However, not all anti-smoking advertisements are equal in terms of their efficacy in changing smoking related beliefs, attitudes, and behaviours. Indeed, a number of studies have failed to find a relationship between anti-smoking advertising and reductions in tobacco prevalence.2–4 Clearly it is important to establish the characteristics of adverts and marketing strategies that are best able to advance tobacco control objectives. Opinions vary, however, regarding just what sorts of adverts are most likely to reduce smoking among youth. Pechmann and Reibling13 suggest that messages that emphasise harm to family, and the socially unacceptable nature of smoking, are likely to be most effective, whereas Goldman and Glantz14 argue that adverts that portray the harms caused by secondhand smoke and the duplicitous nature of the tobacco industry will be most successful. Other research indicates that highly emotional appeals that depict, in graphic detail, the adverse consequences of smoking are likely to be most effective for both youth and adults.15–16 In comparison, advertisements that emphasise youth choice, or that smoking is uncool, such as those developed by Philip Morris, tend to be rated poorly by youth17 and may have a counterproductive effect on tobacco control objectives.18–19 More research is clearly required to establish the features of anti-smoking advertisements that are most likely to change smoking related beliefs, attitudes, and behaviours in ways that are commensurate with reducing the harm caused by tobacco in society.
One important, as yet unanswered, question concerns the extent to which these findings generalise across different nations. Do youth in different countries respond in the same way to anti-smoking messages and appeals? Providing an answer to this question is important for a number of reasons. By establishing the characteristics of advertisements that are effective in a variety of different contexts, the development of new anti-smoking advertisements can be undertaken in ways that are likely to best realise tobacco control objectives. Furthermore, if youth in different countries respond in similar ways to anti-smoking advertisements, a strong prima facie case can be made for the sharing of such advertisements among nations, which could result in considerable financial savings.
The present study was designed to address the way that youth at risk for regular smoking in the United States, Australia, and Britain respond to a variety of different anti-smoking advertisements. Two main research questions were posed: (a) do youth in the United States, Australia, and Britain respond in similar ways to anti-smoking advertising?; and (b) how are different anti-smoking advertisements, with different characteristics, appraised by youth in these three nations?
Advert selection and preparation
In total, 50 advertisements were selected for inclusion in this study. These adverts were produced and aired in the United States between 1997 and 2001, and were sponsored by pharmaceutical companies (n=5), tobacco control programmes (n=37), or tobacco companies (n=8). Because adverts sponsored by pharmaceutical and tobacco companies did not have sufficient variation to study the effects of advert characteristics of primary interest in this study, analyses are only reported for responses to adverts sponsored by tobacco control programmes (n=37). Each advert was coded for its primary target audience (youth or general audience), main theme (cessation methods or strategies, health effects of smoking, health benefits of quitting, secondhand smoke, exposing tobacco industry manipulation, parental or sibling guidance about tobacco, adverts portraying tobacco as "uncool", or other), and for the presence or absence of two executional characteristics: (a) personal testimonial (real people telling how smoking has affected their lives); and (b) negative visceral image (an image eliciting an unrelieved visceral "ugh!" response). Audience, theme, and executional characteristics were coded by agreement among five members of the research team. In table 1 we provide details of these different advert characteristics. Full details of the methodology employed in this study are provided by Wakefield et al.20
Characteristics of the anti-smoking advertisements (n=37)
Study participants and recruitment methods
In total, 615 8th, 10th, or 12th grade (2th, 4th, or 6th year of secondary education in Britain) youths who were either susceptible nonsmokers or experimenting smokers21 participated in this study (n=278 in United States; n=162 in Australia; n=175 in Britain). Participants were similarly distributed by age and sex in the three countries. Youth were recruited by market research agencies in the United States and Australia, and by the Centre for Social Marketing at the University of Strathclyde in Britain.
Data collection procedure
Data collection was carried out from March to May 2001 in the United States (Chicago and Boston), October 2002 in Australia (Melbourne), and July 2002 in Britain (Glasgow). Procedures were standardised at the three sites (except where noted). Each youth attended a rating session with 15 other youth in which they appraised 10 different adverts in a 75 minute period. Groups were facilitated by study personnel, who explained the purpose and format of the session and emphasised the importance of each participant providing honest evaluation of the adverts. Each advert was shown twice, after which the participants completed a one page rating form per advert.
Youth recorded their level of agreement with 16 emotive and appraisal statements about the advert. They were then asked to rate how good they felt each advert was via the question, "Overall, how good was this ad as an anti-smoking advertisement?" (1=not good at all, to 7=very good). Participants in Australia and Britain received a slightly different version of this question, "Overall, I thought this ad was a very good anti-smoking advertisement" (1=strongly disagree, to 5=strongly agree). Youth were then asked if they had seen the advert before on television. At the end of the session participants were asked to indicate "Which one of these ads will most make you stop and think?"
A week after the rating sessions, follow up telephone calls were conducted with each participant. Participants were asked to identify which, if any, of the adverts they could recall from the rating session. For each advert recalled, they were then asked to state whether they had thought more about that advert and whether they had discussed it with anyone outside of the rating session. Finally, participants were asked if they had seen any anti-smoking adverts on television between the rating session and the follow up interview.
Outcome measures and statistical analysis
For the analyses reported in this paper, original data at the individual level were aggregated up to the advert level (n=37), meaning that the responses of all youth who viewed and rated a particular advert were averaged for that advert. These responses should be interpreted as the proportion of youth related to a specific outcome. For example, for advert recall, the variable reflects the mean proportion of youth exposed to that advert that subsequently recalled the advert in the follow up interview. Outcome variables for this study included measures of appraisal and engagement. Appraisal included two measures obtained from the rating sessions: (a) how good ("Overall, I thought this ad was a very good anti-smoking advertisement"); and (b) stand out ("Which one of these ads will most make you stop and think?"). Engagement included three measures obtained during the follow up sessions: (a) recall (the proportion of youth from each rating session who recalled each specific advert at follow up); (b) thought about (the proportion of youth from each rating session who reported having thought about the advert between the rating session and follow up; and (c) discussed (the proportion of youth from each rating session who reported having discussed the advert between the rating session and follow up with someone not in the rating session).
Differences between countries on the main outcome variables were evaluated using analysis of variance, while linear regression analyses were employed to identify associations between advert characteristics and outcome variables, and to test for interaction effects between countries.
Outcomes by country
There were few differences between youth in the United States, Australia, and Britain on the outcome measures for anti-smoking advertisements (see table 2). On average, across the three countries, 56% of the participants rated the adverts as above average on how good, adverts were recalled on average by 37% of youth, thought about by 18%, and discussed by 16%. Consistent with the fact that all adverts were sourced from the United States, youth in the United States reported significantly higher prior exposure to the anti-smoking advertisements, compared with participants in either Australia or Britain. British youth were also significantly less likely to recall the anti-smoking adverts, with an average of 43% of youth in the United States and Australia recalling any given advert, compared with 27% of participants in Britain. This difference remained significant after adding prior exposure as a covariate. As can be seen by the correlations in table 3, youth in the three countries appraised the different anti-smoking adverts in very similar ways. Thus, adverts that were more likely to be chosen as the one that stands out by the Australian participants were also likely to be chosen by youth in the United States and Britain. Moreover, even though participants in Britain were less likely to recall the advertisements, they tended to recall the same ones as youth in Australia and the United States.
Mean proportions (and standard deviations) for main outcome measures by country
Correlations between United States (US), Australian, and British participants for main outcome measures (n=37 adverts)
In order to establish which of the adverts were most likely to be effective in advancing tobacco control objectives, an "advert impact" score was constructed for each advert based on the summed combination of scores (that is the sum of proportions) on three of the main outcome measures: how good, stand out, and discussed. These measures were chosen to provide information based both on advert appraisal and advert engagement. We selected only one measure of engagement (discussed) because recall and thought about were so highly correlated with it (and each other). The internal reliability of this scale was high (α=0.84). As can be seen in table 4, out of the 10 adverts that received the highest impact scores, four were aimed at a youth audience, and themes included health effects, secondhand smoke, industry manipulation, and other. The four adverts with the highest advert impact scores all featured either personal testimonial or visceral negative executional characteristics and all were rated as very good anti-smoking adverts by over 90% of the participants. All of these adverts were also thought about by over 40%, and discussed by over 36% of youth who saw them, suggesting that they have qualities that are most likely to influence smoking related attitudes, beliefs, and behaviours.
Advertisements most positively appraised and engaged by participants*
Multivariate relationships for tobacco control adverts
Full multivariate models were specified for the 37 tobacco control adverts as depicted in table 5. As these analyses included a relatively small n value, we indicate if relationships were observed at the p <0.10 level (non-standard significance), as well as standard significance levels of p <0.05. The target audience of the adverts was not significantly related to any of the outcome measures employed in this study. However, adverts with personal testimonial and visceral negative executional characteristics significantly increased the proportion of participants who rated such adverts as above average on how good, selected them as the one that stands out, and who recalled, thought about, and discussed them at follow up (see table 5).
Multivariate models examining youth cognitive engagement with tobacco control anti-smoking advertising (n=37)†
Prior exposure was also significantly positively related to ratings of how good, stand out, and advert recall, but not to the other outcome variables. There were few significant relations between advert theme and the outcome measures. Using adverts with the theme of health effects as the referent, adverts with a health benefits or secondhand smoke theme marginally increased the proportion of youth that rated them as the one that stands out; and adverts with an uncool theme were marginally less likely to be discussed at follow up.
As we found with the bivariate models discussed previously, the only significant relationship between country and the outcome measures was that the proportion of participants who recalled adverts in Britain was significantly lower. Multivariate models that included all interactions between country, audience, executional characteristics, and advert themes found no systematic significant effects.
The results of the study indicate that anti-smoking advertisements sponsored by tobacco control programmes are appraised and engaged in very similar ways by youth in the United States, Australia, and Britain. The only significant difference found was that youth in Britain were less likely to recall any specific advert when followed up a week later. This finding could not be explained by differences in prior exposure to the adverts or in the amount of time elapsed between the rating session and the follow up call, and probably relates to subtle differences in either the sample or methodology employed (although care was taken to standardise procedures in the three countries).
In this study, the executional characteristics of adverts provided the strongest and most consistent effect on measures of advert appraisal and engagement. The presence of personal testimonial or visceral negative executional characteristics significantly increased the proportion of participants who rated adverts as very good anti-smoking adverts, selected them as the one that most stands out, and who recalled, thought about, or discussed such adverts at follow up. Moreover, of the 10 adverts with the highest impact scores, six featured one or more of these two executional characteristics. Previous research has highlighted the role of personal testimonials in delivering persuasive anti-smoking messages,6,17 and the efficacy of negative visceral images is supported by mass communications theory that emphasises the importance of emotional engagement in communicating messages to audiences who may not be especially interested in the subject matter.16,22 Although marketing theory and some researchers13,23 suggest that adverts should be targeted towards specific audiences, there was no effect of target audience in this study. That is, adverts that were aimed at youth were not appraised or engaged in different ways from those aimed at a more general audience. Indeed, it is interesting to note that the four advertisements that received the highest advert impact scores (see table 4) were all targeted at a general audience and included vivid portrayals of the negative health consequences of smoking (or secondhand smoke). Despite the widespread idea that young people feel they are immortal and therefore an emphasis on the long term health effects of smoking may be inappropriate, research has suggested that threat appeals may be just as effective with youth as they are with adults.24 Although the outcome measures that we employed did not allow us to assess how different adverts influence smoking related attitudes, beliefs, and behaviours, adverts that employed personal testimonial and visceral negative executional characteristics that emphasised the harms of smoking were appraised positively and engaged by youth in all three countries.
One reason why disagreement remains regarding the most effective characteristics of anti-smoking adverts is that such advertisements are complex, multifaceted stimuli that can be rated on a wide range of different dimensions, few of which have been systematically evaluated in research. The different physical, social, and cultural environments in which adverts are placed provides another potential explanation for why such disagreement remains: some adverts might be more effective in some, but not other, cultural historical contexts. However, on the basis of the results presented in this study, it seems clear that youth in the comparatively similar cultural environments of the United States, Australia, and Britain appraise and engage anti-smoking advertisements in very similar ways.
These findings should encourage the open exchange of anti-smoking adverts between such countries, effectively extending the often stretched budgets of tobacco control programmes. Furthermore, this study suggests that tobacco control programmes might seriously consider the use of adverts that test most effectively with people in other similar countries. The evaluation of anti-smoking adverts in more diverse cultural environments is one possible extension of the research presented here, which could pave the way for the more global use of mass media tobacco control campaigns.
Melanie Wakefield is a senior editor of Tobacco Control. She was excluded from editor–reviewer correspondence and was not included in the editorial decision making process for this manuscript.
This study was funded by the United States National Cancer Institute State and Community Tobacco Control Intervention Program, Grant # RO 1 CA86273–01. The study was conducted while Dr Wakefield was the recipient of a VicHealth Senior Research Fellowship. We thank Kim McLeod at The Cancer Council Victoria, Kate Clegg-Smith at the University of Illinois, and Laura McDermott at the University of Strathclyde for moderating the rating sessions. We also thank Jason Boulter at The Cancer Council Victoria, Kathryn Angus at the University of Strathclyde, and Sandy Slater at the University of Illinois for research administration support. In addition we acknowledge the contribution of researchers who gave early input into study design and development of measures, including Gerard Hastings, Lois Biener, Phillip Klafta, David Hill, William Wells, Kim Worden, and Frank Chaloupka.
Bauer UE, Johnson TM, Hopkins RS, et al. Changes in youth cigarette use and intentions following implementation of a tobacco control program: findings from the Florida youth tobacco survey, 1998–2000. JAMA2000;284:723–8.
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Siegel M, Biener L. The impact of an antismoking media campaign on progression to established smoking: results of a longitudinal youth study. Am J Public Health2000;90:380–6.
Wakefield M, Flay B, Nichter M, et al. Effects of anti-smoking advertising on youth smoking: a review. Journal of Health Communication, 2003;8:229–47.
Sly DF, Trapido E, Ray S. Evidence of the dose effects of an antitobacco counteradvertising campaign. Prev Med2002;35:511–8.
Biener L, Harris JE, Hamilton W. Impact of the Massachusetts tobacco control programme: population based trend analysis. BMJ2000;321:351–4.
Sly D, Hopkins R, Trapido E, et al. Influence of a counteradvertising media campaign on initiation of smoking: the Florida "truth" campaign. Am J Public Health2001;91:233–8.
Pierce JP, Macaskill P, Hill D. Long-term effectiveness of the early mass media led antismoking campaigns in Australia. In Hornik RC, ed. Public health communication: evidence for behaviour change. Mahwah, NJ: Lawrence Erlbaum Associates, 1990;57–70.
Hill D, Carroll T. Australia's National Tobacco Campaign Tob Control2003;12(suppl II):ii9–14.
Wakefield M, Freeman J, Donovan R. Recall and response of smokers and recent quitters to the Australian National Tobacco Campaign Tob Control2003;12(suppl II):ii15–22.
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McVey D, Stapleton J. Can anti-smoking television advertising affect smoking behaviour? Controlled trial of the Health Education Authority for England's anti-smoking TV campaign. Tob Control2000;9:273–82.
Pechmann C, Reibling ET. Planning an effective anti-smoking mass media campaign targeting adolescents. Journal of Public Health Management Practice2000;6:80–94.
Goldman LK, Glantz SA. Evaluation of anti-smoking advertising campaigns. JAMA1998;279:772–7.
Hill D, Chapman S, Donovan R. The return of scare tactics. Tob Control1998;7:5–8.
Witte K, Allen M. A meta-analysis of fear appeals: implications for effective public health campaigns. Health Educ Behav2000;27:591–615.
Biener L. Anti-tobacco advertisements by Massachusetts and Philip Morris: what teenagers think. Tob Control2002;11(Suppl II):ii43–6.
Farrelly MC, Healton CG, Davis KC, et al. Getting to the truth: Evaluating national tobacco countermarketing campaigns. Am J Public Health2002;92:901–7.
Landman A, Ling PM, Glantz SA. Tobacco industry youth smoking prevention programs: protecting the industry and hurting tobacco control. Am J Public Health2002;92:917–30.
Wakefield M, Balch GI, Terry-McElrath Y, et al. Assessment of youth responses to anti-smoking ads: description of a research protocol. ImpacTeen Research Paper Series. Chicago, IL: ImpacTeen; 2002;No 23.
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Hafstad A, Aaro LE, Engeland A, et al. Provocative appeals in anti-smoking mass media campaigns targeting adolescents – the accumulated effects of multiple exposures. Health Education Research1997;12:227–36.
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redpajama_set_name: RedPajamaCommonCrawl


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Home > Riviste > The Journal of Cardiovascular Surgery > Fascicoli precedenti > The Journal of Cardiovascular Surgery 2020 October;61(5) > The Journal of Cardiovascular Surgery 2020 October;61(5):639-47
ORIGINAL ARTICLE CARDIAC SECTION
The Journal of Cardiovascular Surgery 2020 October;61(5):639-47
Echocardiographic and clinical outcome after mitral valve plasty with a minimal access or conventional sternotomy approach
Lotte E. de GROOT-de LAAT 1, 2 ✉, Kevin M. VEEN 1, 2, Jackie MCGHIE 1, 2, Frans B. OEI 1, 2, Wouter J. van LEEUWEN 1, 2, Ad J. BOGERS 1, 2, Marcel L. GELEIJNSE 1, 2
1 Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands; 2 Department of Cardiothoracic Surgery, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands
BACKGROUND: The aim of this study is to evaluate the effects of minimal access mitral valve surgery (MAMVS) versus conventional surgery with or without concomitant tricuspid valve plasty (TVP) in consecutive patients with mitral regurgitation (MR) on clinical and echocardiographic outcome.
METHODS: One-hundred-and-twenty patients operated for MR (91 conventional and 29 MAMVS) were followed by echocardiography and quality of life assessment before and 6 months after surgery.
RESULTS: Patients in the MAMVS group were younger, more often in NYHA functional class I-II and had lower NT-proBNP levels. Only four patients (all in the conventional group) underwent mitral valve replacement. There were no significant differences in complications between MAMVS and conventional surgery. At 6 months, comparable MR reduction and left ventricular remodeling data were seen, left atrial remodeling was most prominent in the MAMVS group, 71 [55-90] to 43 [35-58] versus 69 [53-89] to 49 [41-70] mL/m2 in the conventional group (P<0.05). Significant improvement for all quality of life domains were seen, except for pain, with no intergroup differences. Twenty-seven (23%) patients underwent concomitant TVP, all in the conventional group. Tricuspid regurgitation decreased after concomitant TVP (P<0.001), whereas in patients with no TVP no significant changes occurred. At 6 months tricuspid regurgitation grade was comparable in patients with TVP versus patients without need for TVP.
CONCLUSIONS: MR severity reduced significantly, with no difference between conventional surgery and MAMVS in reducing MR, with superior left atrial remodeling in the MAMVS group. In-hospital complications and NYHA class and quality of life assessment were not different between conventional surgery and MAMVS.
KEY WORDS: Mitral valve insufficiency; Echocardiography; Tricuspid valve insufficiency; Mitral valve annuloplasty; Minimally invasive surgical procedures
Issue published online: November 24, 2020
Article first published online: July 20, 2020
Manuscript revised: June 9, 2020
Manuscript received: September 17, 2019
de Groot-de Laat LE, Veen KM, McGhie J, Oei FB, van Leeuwen WJ, Bogers AJ, et al. Echocardiographic and clinical outcome after mitral valve plasty with a minimal access or conventional sternotomy approach. J Cardiovasc Surg 2020;61:639-47. DOI: 10.23736/S0021-9509.20.11127-3
l.delaat@erasmusmc.nl


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Home » Full-game digital downloads to be available at Wii U launch
Full-game digital downloads to be available at Wii U launch
Posted by Alex Seedhouse April 27, 2012 April 28, 2012
Zelda and Midna join Hyrule Warriors as playable characters
Nintendo have revealed that download sales of packaged software will be available from the launch of Wii U.
Such news was confirmed by Satoru Iwata, who outlined Nintendo's plans for the next financial year during an earnings briefing with investors this morning in Japan.
"For the Wii U, we will start the digital download sales of packaged software that I just discussed, so our consumers can choose either the packaged version or the digital download version of the same software from day one of the Wii U's launch," he explained.
Iwata also commented that Nintendo had learnt that consumers are more concerned with the quality of available software rather than the hardware itself.
As a result, Nintendo will ensure that the Wii U is supported by a rich line-up right from launch.
Nintendo also confirmed that they won't disclose Wii U pricing at E3 2012, and that New Super Mario Bros. 2 would also be available digitally.
Tags: digital downloads full game full games Nintendo Satoru Iwata Wii U
Alex Seedhouse April 27, 2012
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The body'€™s inability to work on glucose and make use of it when it is in the blood is an indication of a problem with metabolism which is known as diabetes. The pancreas produces the hormone, insulin, which helps take glucose from the bloodstream into the membrane of the cells so that it can be used as energy. The body of a type 1 diabetic can no longer produce insulin or the amount of insulin produced is insufficient for the process. For a type 2 diabetic, the cells have developed a resistance to insulin. In both cases the amount of glucose in the blood gradually increases until the blood glucose level is too high. To get the cells to be more insulin-sensitive, you need exercise. With the cells more sensitive to insulin, glucose can be quickly taken into the cells.
Exercise is necessary to prevent or treat diabetes. The heart can be strengthened by exercises which improve the condition of the heart and the blood vessels. Strengthening the heart is important as the risk of death from heart diseases for diabetics is many times more than that of non-diabetics. With strength training exercises, there is more muscular contractions which cause an increase the protein, GluT4; and this protein can move even more glucose to the cells of the muscles. With less glucose in the bloodstream, the requirement for insulin is lessened. When there is too big a quantity of insulin in the blood, the glucose level there drops to low to cause dangerous hypoglycemia. This can also lessen the ability to do exercise.
Aerobic exercises should be carried out about 5 days each week for at least 20 minutes but not more than 60 minutes each time is the advice of the ACSM (American College of Sports Medicine). The forcefulness and speed of the exercise should be carefully watched so that they use only between 40 -€" 70% of the body's capability to perform.
When blood glucose levels of type 1 diabetics exceed 240 mg/dL, and type 2 diabetics exceed 300 mg/dL before an exercise, the exercise should not be carried out because it can be harmful. People with proliferative retinopathy are told it is not advisable to do any tiring, intense exercise. Exercise can be harmful to people suffering from serious kidney disease, peripheral neuropathy in the lower extremities, infection and its resultant fever.
About an hour before an exercise, diabetics ought to eat so that their blood glucose levels will be ascending. Blood glucose levels ought to be tested before starting an exercise. If blood glucose levels are low, postpone the exercise. It is wise to have some kind of sugar at hand during an exercise, ready for any unexpected decrease in blood sugar. It is advisable to have a partner while exercising; someone who knows the dangers of hypoglycemia and hyperglycemia, and is able to make the correct response to such occurances.
People who are type 2 diabetics for a period of at least 11 years, are more than 35 years of age, are type 1 diabetics for more than 15 years or have experienced microvascular diseases retinopathy or neuropathy ought to be given clearance by a medical practitioner before taking on any exercise program. For people with peripheral neuropathy, exercises with less impact like biking and swimming should be preferred to jogging and walking.


The Hub is a free and confidential service that helps young people up to the age of 25 with their drug and/or alcohol use. We work across the borough and will come and see a young person wherever they feel comfortable, whether that is at home, in a caf_, or in another service or agency such as a youth club, a job centre or a school. The Hub has a friendly and welcoming service base in Catford shopping centre where we hold activities and run group sessions, as well as seeing young people individually.


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Formation of Guanoxabenz from Guanabenz in Human Liver
A new metabolic marker for CYP1A2
Bernd Clement and Mark Demesmaeker
Drug Metabolism and Disposition November 1997, 25 (11) 1266-1271;
Bernd Clement
Mark Demesmaeker
The in vitro N-hydroxylation of guanabenz as well as the corresponding N-dehydroxylation of guanoxabenz has been previously detected in biotransformation studies with microsomal fractions of different species including human hepatic microsomes. Furthermore, the N-hydroxylation of guanabenz was found to be catalyzed by enriched cytochrome P450 (P450) fractions in reconstituted systems. Strong correlations between 7-ethoxyresorufinO-deethylation (r = 0.96;p < 0.001), caffeine N-demethylation (r = 0.92; p < 0.001), respectively, and guanabenz N-hydroxylation activities were demonstrated in 10 human liver microsomal preparations. Studies with microsomes from human B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes proved that CYP1A2 is the major isozyme responsible for this metabolic pathway. Further, P450 isozymes did not show any detectable conversion rates. The reaction was inhibited in presence of the potent CYP1A2 inhibitors α-naphthoflavone (7,8-benzoflavone) and furafylline. The N-reduction of guanoxabenz to guanabenz exhibits a significant correlation to the benzamidoximeN-reduction after incubation with 10 human liver microsomal preparations (r = 0.97; p < 0.001). The formation of benzamidine from benzamidoxime was described previously to be catalyzed by the benzamidoxime reductase. These results suggest that the guanabenz N-hydroxylation is mediated via CYP1A2, whereas the corresponding guanoxabenzN-reduction is catalyzed by an enzyme system composed of cytochrome b5, NADH cytochromeb5-reductase, and benzamidoxime reductase. The high affinity of guanabenz to CYP1A2 and the distinct selectivity of this P450 isozyme toward guanabenz confirms the in vitro guanabenz N-hydroxylation to be a suitable metabolic marker for CYP1A2 in biotransformation studies.
Send reprint requests to: Professor Dr. Bernd Clement, Pharmazeutisches Institut, Christian-Albrechts-Universitat Kiel, Gutenbergstrasse 76, D-24118 Kiel, Germany.
Abbreviations used are::
triacetylolendomycine
high performance liquid chromatography
Received March 5, 1997.
Accepted July 25, 1997.
The American Society for Pharmacology and Experimental Therapeutics
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.
You are going to email the following Formation of Guanoxabenz from Guanabenz in Human Liver
Drug Metabolism and Disposition November 1, 1997, 25 (11) 1266-1271;


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A Complete Guide To Building A College And Career Readiness Framework
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College and career readiness is a big concept with a lot of moving parts. Preparing students for life after high school is an inarguably important job — we all want today's learners to be tomorrow's fulfilled, productive citizens, which requires a plan. With 50.6 million students enrolled in public school alone as of 2019, that's a lot of plans.
Keeping everyone on track is no easy feat, and that's why it's critical to have the infrastructure in place to build, track, and execute each student's postsecondary plan. Building a college and career readiness framework that starts when students do (elementary school) and provides the follow-through that supports positive student outcomes once they transition to alumni status is a crucial part of this infrastructure.
It's important to note that the key to a successful college and career readiness framework that supports postsecondary planning in this way is that it's centralized — attempting to manage everything with a piecemeal or cobbled-together "solution" can be frustrating, ineffective, and a poor use of student and support staff time.
Building A College And Career Readiness Framework At Every Stage
College and career readiness results from instructive continuity. Any college admissions counselor can tell you that attempting to condense the entire spectrum of readiness initiatives into the four years before high school graduation is a recipe for burnout and grief. Everyone benefits when school districts build a college and career readiness framework to support an end-to-end student experience. Here's what college and career readiness looks like at every age and stage.
College And Career Readiness — In Elementary School?
Believe it or not, there is a way to foster a culture of postsecondary planning in elementary school — and that's important. Elementary students are awfully busy learners. They're doing the important job of laying the foundation upon which the rest of their education will be built.
They're working to understand basic math and literacy concepts, of course, but there's much more going on. They're discovering how to interact with their peers. They're beginning to understand how to learn and how they learn best. They are becoming social creatures, encountering differences for the first time, and discovering things that pique their interests. They are capable of setting goals.
All of this, though it seems far afield of the specifics of college and career planning that older students do as they approach graduation, is very important.
The name for some of this is Social and Emotional Learning (SEL), and providing SEL activities for K-5 students will facilitate the development of social and emotional abilities that become the "soft skills" that are in such high demand in the workforce and so useful for college and career readiness, like:
Self-Efficacy - Believing that we can do what's required to get the job done isn't a simple platitude; it's often half the battle. Confidence and persistence are byproducts of this SEL concept, and students begin cultivating these skills in the early grades.
Teamwork - Few people are ever in a learning or professional environment alone. The ability to work cooperatively is universally valuable, and it's one of the first SEL concepts that students learn, often through play.
Goal-Setting - For very young kids, goal-setting comes from developing impulse control by creating good habits through repetition. It's a skill that will serve them very well as they start to realize their postsecondary goals (college is a big commitment!) Learning to patiently wait for recess or do a classroom job every day lays the foundation for honoring commitments later.
Effective Communication - To get what we want and need in any relationship — whether in our educational, professional, or personal communities — we must communicate effectively. Elementary school is where we all begin to learn how to navigate social cues and adjust our communicative abilities accordingly. Additional guidance from adults in the form of a science-backed SEL curriculum helps our youngest learners navigate them.
Empathy - Empathy is a keystone of emotional intelligence, and it's consistently recognized as a core characteristic of effective leaders. What's lovely about elementary-aged students is their incredible capacity for empathy. SEL activities, discussions, and group work celebrates and encourages empathy at a formative moment in students' lives.
Decision-Making - Making constructive choices about personal behavior and understanding the consequences (good and bad) of those choices is something most adults are still learning to master. Incorporating it into the SEL curriculum at a young age and weaving it into later college and career readiness initiatives is increasingly a priority for student outcome nerds like us.
Young children are capable of the kind of future-focused self-conceptualization that we're constantly asking students to engage in when we ask them to participate in college and career readiness. Often, they don't even know that they're doing it!
Read More: Coming Soon to SchooLinks: K-5 Tools for Social and Emotional Learning
Creating spaces for them to dream as big as possible and providing an environment that encourages social and emotional learning and exploration are two of the most important things that educators and school communities can do to set students up for resonant, relevant, and rigorous college and career readiness.
Middle School: Taking Career Exploration To The Next Level
In the middle grades, a context for college and career readiness starts to take shape. Middle school can be identity-making, or at least, it can certainly feel that way! While identities are dynamic things, they begin to emerge in earnest right around this time. Students start to figure themselves out.
Many states have college and career readiness standards and directives that begin in middle school, which makes sense! As students begin to understand their interests and what they excel at and engage in the "mental time travel" that inspires actual aspiration, those directives are simply a way of asking students to apply these burgeoning skills and enthusiasms into a vision for the future.
College and career readiness in middle school should have a heavy exploration focus in a low-pressure environment. Students are already picking up paintbrushes, athletic equipment, coding languages, and clarinets. College and career exploration at this stage should primarily channel that natural curiosity into a series of questions, like:
What do you think you are good at?
What brings you joy? What makes you feel confident?
What feels challenging?
What do you want to learn to do better?
What's your favorite class? Your least favorite?
What do you do in your free time?
It's an excellent time for students to explore what makes them, well, them! Building a college and career framework that supports the middle grades often means implementing assessments. For instance:
Learning Style Assessments
At this point, most students already have an idea of how they learn best, even if they can't necessarily articulate it. Administering a learning assessment can give students a vocabulary for what they already feel is true about themselves. Then, once they understand that they're a kinesthetic (or visual, or spatial, etc.), they can create strategies for getting the most out of school.
Personality Typing
So long as they aren't delivered as absolute and immutable categories, personality typing can also play an important role in college and career readiness for middle schoolers. Meyers-Briggs, Holland Code, and Jungian typing assessments and activities are all useful tools for students who, again, need an expanded vocabulary to describe the ways that they experience the world and relationships.
Skills And Interest Assessments
For middle schoolers, it can feel bewildering to have to answer the question: "What do you like and what are you good at?" The answer to both questions is crucial to college and career readiness, but even as adults, they can be tough to answer confidently. Skills and interest assessments to the rescue! By providing a series of scenarios and asking students to choose the ones that appeal most to them, you can start a conversation that's far more productive.
All of these assessments can inform something important — career exploration and discovery. In middle school, we can begin to apply all of these newfound discoveries about the self and present to students a world of fulfilling career options to explore just as we equip them with knowledge about what they know and do best.
Students don't necessarily want to be ballerinas and astronauts forever. Once they understand how they can apply their unique skills and talents to the workforce, they'll be really ready to dig into exploring new pathways, well-prepared for the high school college and career readiness experience, where they'll start to turn their dreams into actionable plans.
College and Career Readiness For High School Students
Wait, how did high school sneak up on us? How did we go from circle time to study hall, from eighth-grade "prom" to AP Chemistry? Well, we're here. And once we're here, postsecondary life is practically imminent for students. In these upper grades, the importance of building a solid college and career readiness framework becomes most apparent.
Career discovery as a foundational element of postsecondary readiness can't be overstated. The "gold standard" of the college-going grad is so ingrained and pervasive that for a while, there was a kind of cultural neglect of everything that happens, well, afterward.
Encouraging degree attainment above everything else left a lot of Millennials scratching their heads after college commencement ceremonies. A college degree can undoubtedly confer many benefits, but we have to widen the focus. After all, college lasts just 2-4 years for most people. Isn't it more useful for students to consider why they may want to traverse that path?
Helping students really explore their shortlist of careers: what they pay, where they tend to be, and adjacent fields helps place the education and experience that they'll need to acquire along the way into a deeper context. Because Gen Z is more financially pragmatic than their older Millennial siblings, it's no longer enough to say, "Do what you love." A college and career readiness framework that supports secondary career exploration has to include:
Careers That Align With Student Interest Assessments
This is a great place to start. Often, more careers align with student interests than your standard Occupational Outlook Handbook can hold or the handful of pages in the back of a freshly bubbled Career Aptitude Test might suggest. Make sure your students have access to the avenues that lead to further exploration.
For instance: as a culture, we love to direct our artistic learners toward graphic design. And that may capture the interest of your burgeoning resident Banksy. But what about Industrial Design, Animation, Advertising or Merchandising, UX, or Motion Graphics?
Or, what if it would serve that student better to pursue a job that offers a predictable schedule and work-life balance so they can pursue their passion in their own time and decide for themselves whether they want to try to profit off of it?
Few people are only good at one thing or interested in a single topic. Allowing career discovery to branch out into adjacent and exciting options gives students more options as they consider what they may want to do later in life.
Cost And Quality Of Life: Financial Literacy For High Schoolers
Every career pursuit has an associated cost, and we don't just mean the sticker price of your basic 4-year degree. Increasingly, the most innovative school districts are adding financial literacy initiatives to the college and career framework they use. That means giving students a way to explore:
The cost associated with pursuing the education required for a chosen career
How scholarships, grants, and savings defray that cost and how to leverage them
How to navigate paperwork associated with the FAFSA, state aid, loans, and more
The long-term costs of student loans and how they affect take-home pay, creature comforts, and milestones like home buying or starting a family
This necessarily includes tools that allow students to see where the jobs are, how much it costs to live in the region, and how long those jobs might be there.
All of this is less splashy simple directives to "Do What You Love" or "Hustle Harder", but they allow students to go into the world clear-eyed and confident in their choices.
Help Students Discover New And Rising Careers
Finally, any college and career framework that doesn't include the careers that are just beginning to appear on the horizon is incomplete. The Bureau of Labor Statistics is a valuable tool for students, but it tends to lag a little because it's a snapshot of what is, not necessarily what will be.
The reason the Career Explorer on SchooLinks includes information from LinkedIn is so that students can get a better picture of which careers are hot and rising fast. It helps students see what skills are just beginning to be in demand and whether those skills align with their own.
College Planning At The High School Level
Now, finally, we get to College Planning. Why? Because it's not always helpful to sort through beautiful private liberal arts schools in Vermont or a public university known chiefly for its football team if you're pursuing a career in data analytics or veterinary medicine.
The years and money that students spend on school should work toward their end goals, so it makes sense to allow those goals to take shape first.
College Matchmaking: Helping Students Find A Good Fit
We love U.S. News and their Best Colleges list. It's a great place to start for students overwhelmed by the prospect of sifting through all 5,300 options for postsecondary education in the country today. On SchooLinks, students even have the option to filter college search results by their US News Ranking - it can be very useful.
But should it be prescriptive? Probably not, unless you need a recipe for sleep-deprived, burned-out, and rejection anxious students. Instead, they should be exploring options that work for them and getting excited about finding a good match and leaving the nest (or commuting from home. Savvy!).
A college and career framework that lets students filter and favorite schools that work for them instead of blindly sending out a ream of admissions essays to "elite" institutions just makes sense. It helps students find a postsecondary education solution that delivers the education or certification they'll need to build their livelihoods and increases the likelihood that they'll ultimately graduate because they're likely to feel they fit in.
For instance, if you had a student who wanted to find an HBCU offering a 4-year degree and a Division I Women's Bowling Team, they can find it in four clicks on SchooLinks. With another click, that student could sort the list by graduation rate (or admission rate, or even EFC) and see that Howard University has everything they're looking for, and explore 15 other schools that do, too.
Meeting Graduation Requirements With Backward Course Planning
You've probably noticed a theme by now — backward planning. We started with career exploration, worked backward to postsecondary education, and ended up here — high school course planning for college and career readiness.
This approach is helpful because otherwise, it quickly becomes overwhelming. That's especially true now, as an increasing number of states are adding multiple pathways to graduation, specialty tracks — like Ohio's Diploma Seals or Texas' Endorsement model — CTE and career-ready tracks, dual-credit programs, and individual learning plans.
Working backward from an overarching goal allows students to break down graduation requirements and pick out elective courses, CTE concentrations, and pathways that best serve their interests and aspirations all while staying on track to graduate on time and future-ready.
Career And Technical Education (CTE) & Work-Based Learning
Additionally, any course catalog and accompanying course planner should treat CTE and college-track pathways as the equally valid options they are. Managing your college and career framework from a centralized location can help you build and support a next generation CTE program for students.
It universalizes the process for tracking student interest, participation, and progress, for one thing, and it allows CTE coordinators and educators to see how course credits for their departments and buildings fit into the core academic credits students are already taking. For many districts, CTE feels and operates as an almost completely separate entity, causing CTE administrators and teachers to feel like they're "on their own".
Increasingly, students are taking advantage of work-based learning opportunities — usually offered through their CTE concentration, or at least related to it — and there are federal and state mandates associated with tracking those hours. By pulling CTE into the college and career readiness framework as an equal and significant part of student learning opportunities, it retains its rigor and relevance, while
Advisory Programs And Support Structures
A solid college and career readiness framework is one that understands the role of counselors and respects their time as professionals instead of asking them to pull double-duty as data-entry clerks in an endless maze of Google docs and Excel spreadsheets. That, we know, is easier said than done sometimes.
With a ratio of one counselor to hundreds of students, school districts have a lot to manage, but the advisory and support piece is arguably the keystone component of a school district's college and career readiness framework. It should include:
1:1 Meetings Between Counselors And Students
There's no substitute for a direct conversation with a student, and one-on-one meetings with counselors are where these discussions take place. They provide crucial context, create space for concerns to be addressed, and allow students to speak candidly about their postsecondary plans, school experience, and even personal challenges.
For many students, the school counseling office may also be the sole entry point for mental health services, a fact that's become starkly apparent these past 18 months. Having a system for one-on-one meetings that makes the most of both participants' time and outlines next steps for students — whether in their career discovery process or when it comes to a personal challenge — will be what separates a good college and career counseling framework from a great one.
For instance, SchooLinks allows students and counselors to request virtual 1:1 meetings, respond to those requests immediately, and record the "next steps" those meetings produce all from the same central location.
CCR Event Coordination And Planning
Every school district needs to be able to deliver important information and opportunities to the students who need, could benefit from, or might be interested in them outside of one-on-one environments. Having the ability to easily plan — and execute — FAFSA nights, Opportunity Fairs, and College Rep visits for students when they need them most isn't ancillary to college and career readiness. It shouldn't be ancillary when it comes to your framework, either.
Alumni Outreach And Networking
The whole point of preparing students for life after graduation is to give them the best chance of success when they get there. You won't know if what you're doing to prepare them is actually working unless you have a way to follow up with them. Alumni outreach doesn't just allow districts to collect and measure outcome data, either. Current students benefit from a healthy alumni network, too.
Current students benefit from the near-peer mentorships, college and career information sessions led by someone who has firsthand knowledge, and simple representation that alumni relations can provide. When it comes to your former students, especially those in underrepresented student groups, having a firm connection to the school community can help sustain important relationships and drive positive outcomes, too.
Collecting And Analyzing Student Data To Improve College And Career Readiness
If you think of your college and career framework as a literal framework, imagine what would happen if you set it up and then never touched it again. Would it be just as functional and strong in a year? Five years? A decade or more?
Probably not. As with any other framework, the college and career readiness structure has to be built upon, maintained, and repaired or upgraded from time to time. One of the most important tools school districts use to do this is data. To some extent, every school district has to collect and report on demographic, performance, and outcome data according to state and federal accountability metrics.
But for schools that are hoping to future-proof their college and career readiness initiatives and departments, meeting state mandates is just the tip of the iceberg. Data-forward districts leverage student data to create informed goals for the school year, build whole-child report cards, boost FAFSA completion rates, and create a "portrait of a graduate" to demonstrate their college and career readiness vision.
That's hardly a complete list, of course, but it demonstrates the breadth of use cases for improving preparedness with data. Some districts have accountability departments or data specialists to facilitate acting on the data they collect, but not having those resources doesn't mean school districts have to forego their benefits!
Edtech is increasingly the vehicle for college and career readiness data collection and analysis, narrowing the "data gap" between districts and leveling the playing field for students. For instance, on SchooLinks', simplified data dashboard views make student data accessible to the counselors and educators that can make the most impact. Counselors and CTE coordinators can navigate between cohort and individual student data with just a few clicks, and school districts can configure accountability metrics to track, well, just about anything.
Determining what that will be comes down to asking some basic questions, for example:
How do we measure college and career readiness for every student?
How do we track progress toward college and career readiness goals?
What's the best way to make sure every student meets graduation requirements?
...and then building and updating the college and career readiness framework to answer those questions.
On SchooLinks, each piece of the college and career framework you build can work together, all on one modern and centralized platform.
Engaging student activities keep students in charge of and invested in their postsecondary plans.
Planning modules align their interests to actionable next steps.
Alumni, family, and industry partner portals bring every stakeholder to the table. Configurable accountability metrics and real-time activity tracking takes student data out of the silo
When you build a college and career readiness framework on SchooLinks, everything works together to turn student dreams into actionable plans.
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A suspected couple of serial killers have been arrested in Moscow, investigators reported. They are believed to have killed at least seven people in a crusade to 'cleanse' the city of its homeless population.
The killings were committed between July 2014 and February 2015, Russia's Investigative Committee said in a statement. The suspects, a 20-year-old man and a 25-year-old woman, targeted "homeless people with alcohol addiction." The man said he wanted to 'clean' the city.
Lifenews tabloid website said the list of the duo's victims may be longer. According to its report, the suspects, named Pavel and Elena, have stabbed and beaten to death 12 people.
The first of them, identified by Lifenews as 35-year-old Stanislav Evseev, had 107 stab wounds to his body, according to his father. Ironically, the victim was not homeless, but rather passed out on a park bench after drinking too much beer with his friend.
The evidence in the other killings pointed to the same MO – dozens of stabs delivered to helpless victims, the tabloid said.
The alleged killers were reportedly caught after failing to finish off their last intended victim on Sunday last week. The man, who works as a street cleaner, fended off the attackers with a screwdriver.
Despite suffering from several knife wounds, he managed to get home and call for help. The man, who was taken to hospital and is currently in an intensive care unit, gave police a description of the two assailants, which lead to their arrest, Lifenews said.
The police reportedly investigated the possible involvement of two other accomplices in the killing spree.


Taking place over a span of four days (May 18-21), the Malibu Guitar Festival – presented by D'Angelico Guitars — rocked its host city for a third consecutive year. And like last year, it was the opening night fundraiser at the Casa Escobar restaurant, benefiting special needs and struggling children (e.g., Therasurf, Emily Shane Foundation, and Native American youth of The Karl LaDue Wodakota Foundation) that set the triumphant tone for the rest of the festival.
(L-R) Kenneth Brian and Bernard Fowler performed on opening night of the third annual Malibu Guitar Festival at Casa Escobar restaurant.
There were also two special honorees: a humanitarian award was bestowed to Chief Arvol Looking Horse, keeper of the sacred bundle (a collection of holy items used in ceremonies) for the Lakota, Dakota, and Nakota nations; and guitarist Robby Krieger of The Doors received a lifetime achievement award for his invaluable contribution to rock 'n' roll. The night also featured, on the stage, a veritable who's who of notable musicians, including Rolling Stones backup vocalist Bernard Fowler, multi-time Grammy nominated singer-songwriter John Hiatt, country star Hunter Hayes, guitarist/singer Pete Pidgeon, Wings guitarist Laurence Juber, the Kenneth Brian Band, and much more.
The gala had a more focused feel and energy than the previous year, somber in the wake of Chris Cornell's passing the day before, and celebratory in the sense that this was a group of veteran rock dignitaries coming together to honor the city of Malibu and the music community as a whole. These were a tight-knit group of individuals, comprising a family at large, and their heartfelt words were proof of this.
One of the individuals on hand was accomplished rock photographer, Lisa Johnson, who was clearly distraught at the news of Cornell's death, but was grateful about the strength-in-numbers aspect of the Malibu Guitar Festival — and other functions of this ilk — that had congregated so many talented folks in one place.
"The root purpose of this is about bringing people together for a good cause, and bringing different generations on stage that you would never see anywhere else, such as Kenneth Brian and John Hiatt," said Johnson.
Pete Pidgeon, a skilled guitarist and singer, was conscientious about courageously taking on the weight of the tragedy by paying tribute to Cornell in his own way, having spontaneously texted festival founder Doug DeLuca about performing Temple of the Dog's "Say Hello 2 Heaven" on opening night.
"I was up late last night until 1:00 am when it [Cornell's death] was announced. I saw it via friends on Facebook. I was very upset and made phone calls. I texted Doug DeLuca to come in and he fit me right in and they were already booked enough as it was," revealed Pidgeon, who was exceptionally proud to be a part of the event.
For guitarist, vocalist and primary songwriter, Kenneth Brian (of his eponymously named band), it was just as much a night of remembrance as it was for moving ahead and doing his due diligence as a consummate professional. The Kenneth Brian Band was in high demand at the festival, as they not only kicked off their new album release – "With Lions" – on May 18th, but spent as much as 15 hours a day rehearsing with other acts, like John Hiatt. Brian, moreover, kept perspective and was cognizant about the greater meaning the festival signified.
"For me, this is about Chief Arvol Looking Horse and the fact that the native people have no voice. People need to know their struggle and give their struggle much more attention," Brian offered insightfully.
Sentiments relating to worthwhile causes, togetherness, and love were recurrent themes on the 18th. Curiously, while he didn't perform, it was Malibu native and musician Brandon Jenner who keenly connected not only what the Malibu Guitar Festival has meant to him, but to a city that he has always been proud to call home.
Son of Caitlyn Jenner and member of the prominent Jenner-Kardashian clan, Brandon Jenner, who once even played at the bar mitzvah of DeLuca's son, is quite possibly the most down-to-earth person anyone could ever meet. With newborn baby girl and wife Leah at his side, who also doubles as his bandmate (dually known as Brandon and Leah), Jenner also has a recent solo album ("Burning Ground") to his credit. Yet, as gifted as a musician he is, what more so distinguishes Brandon is his humanity, and affection for Malibu, including its Chumash heritage and people.
"It's a little small town community, and it has grown up so much, and tonight is even bigger. [The familial nature of the event is symbolic] of when I go to a market and I see a lot of people I know and have chats with them. I love people and it's important to dig deep to get to know them and their stories," explained Jenner.
One would be hard-pressed to find more inclusive and all-encompassing words epitomizing the first night of the Malibu Guitar Festival on May 18th than the ones voiced by Jenner. To Jenner's point, these musicians are unapologetic for who they are, but you can't fault them for it. You can only respect these rockers – young and old – who came together in Malibu for the third consecutive year. Needless to say, they hit another home run — this time in gritty fashion — despite the inauspicious news of Cornell's passing just the day before.


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iPhone 5 Carrier Comparison: T-Mobile vs. AT&T vs. Verizon vs. Sprint
The iPhone 5 is finally available on T-Mobile, joining the iPhone 5 on AT&T, Sprint and Verizon complete with access to 4G LTE and a collection of new iPhone 5 plans with the potential to add features and save money on your monthly bill.
Apple now offers the iPhone 5 and iPhone 4S on all the major U.S. carriers, which potentially means the best iPhone carrier is not the one you are currently using.
Starting in April the T-Mobile Phone is finally available direct from the carrier, for the low price of $99 up front. This is $100 cheaper than the iPhone 5 on the other major carriers.
Even with the new T-Mobile no contract plans, it's not practical or easy to switch iPhone carriers so we recommend checking out the competition before buying a new iPhone. On the upside, the iPhone 5 works on multiple networks so it is possible to take an iPhone to another carrier in certain cases.
The iPhone 5 is now available on T-Mobile, AT&T, Verizon and Sprint.
Apple doesn't yet offer the iPhone 5 carrier comparison tool with the latest T-Mobile plans, but we've done the math to find the best iPhone 5 carriers, which may not always be the cheapest iPhone 5 plan or carrier. In our carrier comparison we look at various plans, and pick an average plan that fits most users, it may not be the average price paid by all customers.
Why You Want a Verizon iPhone 5
Why the Verizon iPhone 5 is the best carrier and plan combination.
Verizon still offers the largest 4G LTE network in the U.S. and customers consistently rank Verizon with the highest network rating and the highest customer service ratings. The Verizon 4G LTE network covers 89% of the U.S. population according to Verizon. This means coverage of 486 cities across the United States.
Verizon 4G LTE coverage for iPhone 5.
While purchasing an iPhone 5 on Verizon, most users will need to pick a new Share Everything Data plan without unlimited data. While existing customers can still pay full price for an iPhone 5 to keep unlimited data, the average user will be going with a new plan.
Verizon sells the iPhone 5 unlocked, which means that users can take it to AT&T, T-Mobile or pre-paid carriers without waiting to get the phone unlocked. This also makes it easier to use the iPhone 5 on an international carrier while traveling.
The video above shows a Verizon iPhone 5 4G LTE speedtest in the Midwest.
Verizon iPhone 5 plans
Below we compare the cheapest, average and highest priced iPhone 5 plans on Verizon. These plans are for an individual user, but Verizon's family share plans allow users to add-on an additional iPhone for $40 a month.
Lowest Price: $80.00/month ($1,920 over 2 years) – Unlimited talk and text, 300MB data.
Average plan: $100.00/month ($2,400 over 2 years) – Unlimited talk and text, 2GB data.
Highest Price: $415/month ($9960 over 2 years) – Unlimited talk and text, 50GB data.
This makes the average cost of the iPhone 5 on Verizon $2,599 for two years.
Update: Verizon offers a $70 a month individual plan in store or on the phone.
These Verizon iPhone 5 plans include the use of the iPhone 5 as a personal hotspot for no extra charge. Users can upgrade to an extra GB of usage for $10 a month. Overages are $15 per GB for a month after the fact.
Why You Want an AT&T iPhone 5
The AT&T iPhone 5 is available now.
AT&T doesn't offer the same reach as Verizon's 4G LTE network, but the AT&T is making great progress on the 4G LTE front. AT&T also backs up a 4G LTE network with a faster than 3G — HSPA+ '4G' network that fills in the gaps in smaller communities.
AT&T's 4G LTE network is available in 154 markets and the slower 4G network covers 288 million people.
AT&T 4G LTE coverage for iPhone 5.
AT&T doesn't make users choose a family share plan like Verizon does, but AT&T offers Mobile Share plans with a cheaper option for families and multi-user accounts.
The video above shows a Verizon iPhone 5 vs. an AT&T iPhone 5 with 4G LTE in San Francisco.
AT&T iPhone 5 Plans
AT&T offers individual and Mobile Share plans, and includes rollover minutes which are not available on other carriers.
Lowest price: $59.99/month ($1439.76 over 2 years) – 450 minutes, 300MB of Data and pay as you go texting.
Average price: $85/month ($2040 over 2 years) – Unlimited talk and text, 1GB data.
Highest price: $230/month ($5,520 over 2 years) – Unlimited talk, text and 20GB of Data.
AT&T Mobile Share plans start at $85 a month with 1GB of data and includes a mobile hotspot service in the price.
With these calculations, the average price of an iPhone 5 on AT&T, with a usable amount of data is $2,239 including the price of the 16GB iPhone 5.
Why You Want a Sprint iPhone 5
The Sprint iPhone 5 connects in more markets than at launch.
Sprint is no longer the only iPhone 5 carrier that offers an unlimited data plan with no limits, if T-Mobile's claims hold up.
Sprint cannot match AT&T and Verizon 4G LTE networks, but the company has over 100 markets it plans to bring 4G LTE online in during the coming months. The Sprint 4G LTE map below shows current 4G LTE coverage, which is larger than T-Mobile.
Sprint 4G LTE coverage for iPhone 5
Sprint offers some Family plans, but puts the marketing on the individual plans with Unlimited data. The video below shows off the Sprint iPhone 5 4G LTE speed test, compared to Verizon and AT&T.
Sprint iPhone 5 Plans
The big Sprint pull is the unlimited data plans, highlighted below.
Lowest price: $79.99/month ($1919.76 over 2 years) 450 minutes, unlimited messaging, unlimited data.
Average price: $109.99/month ($2639.76 over 2 years) Unlimited everything.
Family Plan with 2 lines: $209.99/month ($5039.76 over 2 years) Unlimited everything.
The total cost of the iPhone 5 on Sprint, for two years, with a 16GB iPhone is $2838.76.
Why You Want a T-Mobile iPhone 5
The T-Mobile iPhone 5 arrives April 12th.
The T-Mobile iPhone 5 can connect to 4G LTE, but there is a limited number of locations with 4G LTE connectivity. T-Mobile is launching 4G LTE with seven cities, and plans to expand to cover 200 million users by the end of 2013.
T-Mobile currently offers 4G LTE in Baltimore, MD, Kansas City, KS, Houston, TX, Las Vegas, NV, Phoenix, AZ, San Jose, CA and Washington D.C — with plans to bring New York City online soon.
The T-Mobile iPhone supports data and voice at the same time and it supports HD Voice. Sprint is the only iPhone 5 carrier with support for HD Voice. HD Voice promises better iPhone call quality.
T-Mobile 4G LTE speed test.
The image above shows a T-Mobile 4G LTE speed tests, which illustrates how fast the T-Mobile iPhone can connect in 4G LTE areas.
T-Mobile iPhone 5 Plans
T-Mobile's claim to fame is the lack of contracts for wireless service and the cheaper iPhone 5 up front price.
Lowest Price: $50.00/month ($1,200 over 2 years) – Unlimited talk and text, 500MB of 4G LTE data.
Average plan: $60.00/month ($1,400 over 2 years) – Unlimited talk and text, 2.5GB of 4G LTE data.
Highest Price: $70/month ($1680 over 2 years) – Unlimited talk and text, Unlimited 4G LTE data.
The price of the iPhone 5 adds $20 a month to each of these plans and the up front cost is $99. This means the price of the average T-Mobile iPhone 5 plan, with the 16GB iPhone 5 is $1,979.
T-Mobile offers added lines for $30 for the 2nd line and $10 for additional lines after that.
Why You Don't want an iPhone 5 on Verizon
Verizon does not offer 4G HSPA+ so in areas without 4G LTE, Verizon is often slower than AT&T.
New Verizon customers need to purchase a Share Everything plan, even without any other devices.
The cheapest plan for new customers is $80, $20 a month more than AT&T.
Sprint's Unlimited data plan is available for a penny less than Verizon's 300MB plan.
No Voice and Data at the same time.
Why You Don't want an iPhone 5 on AT&T
AT&T is known for poor network performance in major metropolitan areas like New York City and San Francisco.
AT&T constantly comes in behind Verizon for Network performance and customer service, and below Sprint in some areas.
AT&T's plans are higher than Sprint's unlimited plans for less data.
No Mobile Hotspot feature available for the cheapest plan and no iPad hotspot support yet.
iPhone 5 carriers go head to head.
Why You Don't want an iPhone 5 on Sprint
Sprint 4G LTE coverage is less than Verizon and AT&T.
Until Sprint's new 4G LTE cities are live, users will need to rely on slow Sprint 3G speeds.
Low data users will find a better deal at AT&T or T-Mobile.
The Mobile Hotspot feature is not included in plan pricing, costs $30 a month extra.
No data and voice at the same time.
Why You Don't want an iPhone 5 on T-Mobile
T-Mobile claims the lowest 4G LTE coverage areas.
T-Mobile only includes a small amount of personal hotspot data in its plans.
While there are no wireless service contracts there is a device contract to pay off the Phone 5 over two years.
T-Mobile offers a smaller coverage area with more gaps then AT&T, Verizon and Sprint – especially in rural areas.
Related Topics:AppleAT&Tcarrier comparisoniphonePhone 5SprintT-Mobileverizon
Average plan: $60.00/month ($1,400 over 2 years) – Unlimited talk and text, 2GB* of 4G LTE data.
U need to get your facts straight. Certain Verizon and Sprint phones like the GS3 does support svdo which is simultaneous 3g and voice my EVO LTE can do it and all Verizon and sprint LTE phones have svlte which is simultaneous voice and lte.
You need to read the title. This is an iPhone comparison. His facts are accurate, yours are irrelevant.
Tsampis ting
Terrell, Doug is correct.
B eezy
If you want your phone to never have LTE come to Sprint. My year old HTC Evo LTE moves with lightening speed on the nations slowest 3g network.
I work for a company whose client is Sprint, but have T-mobile for my personal phone. The article mis-represents Sprint's hotspot pricing. 2 GB is $19.99/mo and 6 GB is $49.99/mo. Those are currently the only two plans. I only get 500 MB with T-mobile, but it's free. You pay $10.00 for 2 GB and $20 for 4 GB on T-mobile. I am pretty happy with T-mobile, maybe not as good as Verizon, but I prefer value, even over data speeds and such.
alpha delta lima (@ThePrufessa)
The only thing you didn't point out is T-Mobile I'd unlocked and if traveling to an area where at&t has better coverage then you can easily buy an AT&T Chip and use it temporarily. T-Mobile wins hands down. They've changed the game completely.
hunnydusstNunya
You forgot to mention that when you hit 100 MB or 300 MB in off network data with Sprint, you'll be charged $256 per GB. "Truly Unlimited" does not exist.
4gunlimited
If you want unlimited 4G for $49 no contract and use your iphone http://www.solavei.com/ahfex
This doesn't make sense:
"The T-Mobile iPhone supports data and voice at the same time and it supports HD Voice. Sprint is the only iPhone 5 carrier with support for HD Voice."
bobsinla
I love the theme in the pics above with the different icons and badges, what is it called?
Can you really bring a Verizon iPhone to AT&T and/or T-Mobile? Isn't the Verizon iPhone an A1429, while the AT&T iPhone and T-Mobile iPhone an A1428?
So I Live In Dallas . Would At&T Be Good ?


text:
Kit htaccess
============

Ce kit est une base complète de fichier htaccess prêt à l'emploi, sous réserve d'un peu de personnalisation.

Ce fichier a été construit à partir des références suivantes :
* [server-configs-apache](https://github.com/h5bp/server-configs-apache/blob/master/.htaccess) du projet HTML5 Boiler Plate
* [bpi-htaccess](https://github.com/inseo/bpi-htaccess/blob/master/.htaccess) de Corinne Schillinger
* Fichier htaccess personnalisé de Gaël Poupard

Projet sous [licence MIT](http://opensource.org/licenses/MIT "The MIT licence").

redpajama_set_name: RedPajamaGithub


Shingles is caused when the same varicella zoster virus that causes chickenpox becomes reactivated. In most adults older than 50 years, shingles virus is dormant in the nervous system, and a person's risk for shingles rises sharply after age 50 years.
Shingrixwas approved in the United States and Canada in October 2017 and has been recommended by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices as the preferred vaccine for the prevention of herpes zoster and related complications for immunocompetent adults aged 50 years or older.
The approval of Shingrix was based on a phase 3 clinical trial program that evaluated the drug's efficacy, safety, and immunogenicity in more than 38,000 people.
Cite this: Shingrix Approved in Europe and Japan for Prevention of Shingles - Medscape - Mar 23, 2018.


text:
Q: get the selected text with window.getSelection() in ionic angular How should I implement the window.getSelection().toString(); in an ionic app? I tried to get the plain text of the selected text from ionic textarea but I don't know how my app will be able to listen to that event.
At first, I'm trying to use the press gesture and get the selected text. But then it's not the correct way to do as when I move the app cursor selector to another text to select more text, my app no longer be able to listen to that selection event.

redpajama_set_name: RedPajamaStackExchange


Marks Diageo's latest step in reclaiming leadership position in tequila in North America Joint venture follows successful strategic alliance to build Cîroc ultra-premium vodka brand.
Diageo, the world's leading premium drinks business, and Sean "Diddy" Combs today announce the creation of a new joint venture, which has acquired prestige tequila brand DeLeón.
The joint venture, a 50/50 global partnership between Diageo and Combs Wine & Spirits, builds on the separate strategic alliance formed by Diageo and Combs Enterprises to develop and grow the Cîroc ultra-premium vodka brand. Since the alliance began in 2007, Cîroc has grown from just 50,000 cases a year into a nearly 2 million case brand. The joint venture acquisition of DeLeón will allow the brand to benefit from Diageo's strong distribution network, supply chain, and marketing capability and Sean Combs' access to influencers and proven track record of marketing luxury lifestyle brands.
DeLeón is a 100% blue weber agave boutique tequila brand with a loyal following in Hollywood and the U.S. music industry. The brand has strong appeal with status-conscious consumers who choose spirit brands as part of their luxury lifestyle. The acquisition of DeLeón will accelerate Diageo's share of ultra-premium and above ($40+) tequila, which is the second-fastest growing segment of the tequila category in the U.S. DeLeón has five variants with suggested retail prices ranging from $120.00 to over $1,000.00. The brand has been distributed in 18 U.S. states and Washington, D.C.
"Celebration is a cornerstone of all my businesses, and this joint venture is a natural extension of that portfolio," said Sean Combs, Chairman, Combs Wine & Spirits. "DeLeón is an outstanding brand that appeals to those who love exceptional tequila in a distinctive bottle. Together with Diageo, we will take DeLeón to new heights."


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{

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    {
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        $this->setAttribute('method', 'post');
        $this->setAttribute('id', 'login_form');
        $this->setAttribute('class', 'stdform');

        $this->add(array(
            'name'       => 'username',
            'required'   => 'true',
            'attributes' => array(
                'type' => 'text',
                'id'   => 'username',
            ),
            'options'    => array(
                'label' => 'Username'
            )
        ));

        $this->add(array(
            'name'       => 'password',
            'required'   => 'true',
            'attributes' => array(
                'type' => 'password',
                'id'   => 'password',
            ),
            'options'    => array(
                'label' => 'Password'
            )
        ));
    }

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    {
        if (!$this->inputFilter)
        {
            $inputFilter = new InputFilter();
            $factory     = new InputFactory();

            $inputFilter->add($factory->createInput(array(
                'name'       => 'username',
                'required'   => TRUE,
                'filters'    => array(
                    array('name' => 'StripTags'),
                    array('name' => 'StringTrim'),
                ),
                'validators' => array(
                    array(
                        'name'    => 'NotEmpty',
                        'options' => array('message' => 'Username cannot be empty'),
                    ),
                ),
            )));

            $inputFilter->add($factory->createInput(array(
                'name'       => 'password',
                'required'   => TRUE,
                'filters'    => array(
                    array('name' => 'StripTags'),
                    array('name' => 'StringTrim'),
                ),
                'validators' => array(
                    array(
                        'name'    => 'NotEmpty',
                        'options' => array('message' => 'Password cannot be empty'),
                    ),
                ),
            )));

            $this->inputFilter = $inputFilter;
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    }
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?>


text:
Negative Attachment
It's expected to form an attachment to the people in your life. After all, human beings are social animals. Attachment is the emotional bond that forms between you and someone else.
But sometimes that bond can become negative. Negative attachment is when the emotional bond turns into something harmful. Recognizing negative attachment is the first step to addressing it.
What Is Negative Attachment?
Negative attachment is an unhealthy emotional bond between two people. It's a one-sided relationship where one person is very dependent on the other. This can lead to possessiveness, jealousy, and even abuse.
If you're in a negative attachment, it's important to seek help. There are many resources available to help you address the issue.
What Causes Negative Attachment?
Many factors can contribute to a negative attachment. It can be the result of a traumatic event, such as abuse or neglect. It can also be the result of a difficult childhood or a history of unstable relationships.
Negative attachment can also stem from mental health conditions, like anxiety or depression. If you have a mental health condition, it's important to seek treatment.
What Are The Effects Of Negative Attachment?
Negative attachment can have many harmful effects. It can cause stress and anxiety, and it can lead to depression. It can also cause problems in other areas of your life, such as your work or school performance.
What are the Different Attachment Styles?
There are four different attachment styles: secure, anxious-ambivalent, avoidant, and disorganized.
Secure Attachment Style
Secure attachment is when you feel close to someone. You're comfortable being dependent on them.
Anxious-Preoccupied Attachment Style
Anxious-ambivalent attachment is when you want to be close to someone. But you're afraid of rejection.
Avoidant Attachment Style
Avoidant attachment is when you don't want to be close to anyone and you prefer to be independent.
Disorganized Attachment Style
Disorganized attachment is when you're confused about your feelings. You don't know how to respond to them.
What Is The Attachment Theory?
The attachment theory says we form attachments with the people in our lives to feel safe and secure. The theory was first proposed by John Bowlby in the 1950s.
Many studies support the attachment theory. It's also considered one of the most influential theories in psychology.
How To Tell You're In A Negative Attachment Relationship?
There are many signs of a negative attachment. If you're in a negative attachment, you may feel:
Jealous or possessive of the other person
Fearful of rejection and abandonment
Needy and clingy
Afraid of being alone
Controlled by the other person
It's vital to recognize when you're in an insecure attachment style so you can seek help. That way, you can avoid negative emotions and improve your relationship.
Tips For Dealing With Negative Attachment
You can do many things to deal with negative attachment, like:
Seek Support
Talk to someone you trust about what you're going through. It can be a friend, family member, therapist, or counselor. You can also spend time with friends and family. These positive relationships can help you feel better about yourself and your situation.
Therapy can help you understand attachment styles and process your emotions.
Join a support group. It can provide you with support and understanding from others who go through the same thing.
Books on attachment and relationships can teach you about the issue and how to deal with it.
Avoid Social Media
Social media can make attachment issues worse by triggering jealousy or insecurity.
Negative attachment is an unhealthy emotional bond between two people. It can cause stress and anxiety and can lead to depression. If you're in a negative attachment, seek help to steer your relationship back on track.
Energy healing can help you achieve peace to process your situation. To learn more, check out Bliss Up Now's 5-part docuseries!


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THQ auction sees Sega, Ubisoft, Deep Silver picking up franchises.