The rising death toll from our nation's opioid epidemic has been rivaled in modern history only by that at the peak of the AIDS epidemic in the early 1990s. Consider, in 1995 at the peak of the AIDS epidemic, 51,000 Americans died from the disease. In 2015, 52,000 died from drug overdoses. Emergency departments have stood at the front lines of both crises. As a specialty that prides itself on rising to the occasion at times of great need, our time to lead on this crisis is now. As a response, EDs nationwide are expanding their roles in the care of patients with opioid use disorder (OUD), and many have begun ED-MAT programs. In December of 2017, we launched the Get Waivered Campaign which aimed to get our physicians the DEA X waivers needed to be able to prescribe ED-MAT(buprenorphine) to patients coming to our hospital seeking recovery. In May of 2018, our ED instituted its first ED-MAT protocol and while greater than 90% of our attending physicians had their DEA-X waivers and were able to prescribe buprenorphine, we found that there remained an opportunity to increase the rate of MAT initiation in our ED. Through semi-structured interviews we set out to examine the barriers to providers' use of our MAT initiation protocol and patients' willingness to seek help in obtaining OUD treatment in our ED. Our work has identified multiple barriers, affecting both providers and patients, that have limited wide-scale early adoption of our protocol. The barriers identified from our ED-MAT program's first year of operation, and the interventions aimed at making the use of our ED-MAT protocol as effortless as possible may serve as useful lessons as other hospitals seek to lead by operationalizing their own ED-MAT programs.


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02.11.2021 News . Corporate
Primevest Capital Partners lifts AUM to €2.8 billion with drive into private investors market through Holland Immo Group acquisition
Pan-European investment manager Primevest Capital Partners has expanded its presence in the private investor market and lifted its assets under management to approximately €2.8 billion through the acquisition of Eindhoven-headquartered Holland Immo Group.
AIFM-regulated Holland Immo Group offers funds specialising in residential properties, healthcare real estate and car parks to both private and institutional investors and has AUM of €0.9 billion across more than 25 real estate funds in the Netherlands, Germany, Italy, and Spain. The purchase price was not disclosed.
Peter Helfrich, Managing Partner at Primevest Capital Partners: "Holland Immo Group has an outstanding reputation in the Netherlands thanks to the performance of its funds, its strong and loyal client base and an excellent track record that goes back more than two decades. We have very complimentary businesses and through the 30-strong team of Holland Immo Group we will have direct access to established relationships with private investor clients and family offices. This deal also adds a wealth of knowledge to our already experienced team and will further strengthen our capabilities across all areas including acquisitions, asset and risk management and compliance. We have set out a vision to help our clients to provide for their sustainable financial future through investing in the future of our cities by delivering sustainable urban living, improving connectivity, and enabling mobility, and this acquisition will help us to deliver on our ambitions."
Manfred Kühl, Chief Executive Officer at Holland Immo Group: "Both Primevest and Holland Immo Group are boutique firms specialising in alternative real estate assets that are seeing huge demand from investors and occupiers. As a combined group we can offer a highly professional team, strong fund and asset management expertise and a large acquisition network across these niche markets. We are a great fit in terms of assets under management with portfolios across the residential, healthcare and parking segments, and with Primevest's focus on institutional investors and our own on private investors and family offices, we are expanding our access to new investor groups."
The market for real estate investment funds, including alternative asset classes such as car parks and telecommunications infrastructure, has shown steady growth over the last decade. Demand for these funds from private and semi-institutional investors will accelerate further as the population gets structurally older and the need for individuals to manage their own retirement schemes increases. The low interest rate environment is leading to a rotation from government bonds and savings accounts into other asset classes as a rising number of private investors follow the lead of institutional players and look elsewhere for stable income sources for their personal retirement schemes.
Numerous studies show that indirect real estate investments through fund vehicles provide diversification benefits combined with inflation hedging. Greater regulatory protection has helped boost private investors' confidence and interest in such products and the growth of online services and fintech solutions is also expected to improve access to these specialist vehicles.
Peter Helfrich concluded: "We are seeing significant growth in the private and semi-institutional markets following a growing group of people making their own retirement provisions and are looking for a trusted provider in this market. Primevest Capital Partners, together with Holland Immo Group, can fulfil that need and offers a comprehensive and expanding range of investment opportunities for its clients."
Peter Helfrich and Gaston Hupkens joined Primevest Capital Partners in August this year as Managing Partner and Head of Operations respectively. The senior management team includes partners Bart Pierik, Hans-Peter Renk and Bas van Dongen. Together with Holland Immo Group the combined team consists of approximately 70 professionals who will continue to operate from offices in Utrecht, Eindhoven and Berlin.
Primevest Capital Partners Holding B.V. consists of Primevest Capital Partners Nederland B.V., Primevest Capital Partners Deutschland GmbH and Holland Immo Group B.V. The Board of Primevest Holding, comprising Peter Helfrich, Gaston Hupkens and Bart Pierik, is indirectly responsible for the management of both Primevest Capital Partners and Holland Immo Group. Peter Helfrich and Gaston Hupkens will join the board of Holland Immo Group. The total combined volume of the portfolio is approximately €2.8 billion.
About Primevest Capital Partners
Primevest Capital Partners is a pan-European investment boutique that specialises in investments in innovative real assets. At Primevest Capital Partners, our vision is to future-proof our cities by delivering better urban living, connectivity and mobility as we invest across Europe in contemporary, affordable homes, communication infrastructure and car parks. Our investment philosophy and vision are energised by the current trend of urbanisation and the ability to fulfil the modern needs of metropolitan communities, while enhancing the quality and sustainability of people's lives. From our offices in Utrecht and Berlin, a team of 40 professionals manage €1.9 billion of assets across six sector-focused funds and two individual institutional mandates.
About Holland Immo Group
Holland Immo Group offers real estate investment funds to private and institutional investors as well as family offices. Founded in 2001 by Manfred and Thomas Kühl, the company has since initiated 54 vehicles with a total investment volume of €1.6 billion. Holland Immo Group invests in Dutch homes, parking garages and German convenience stores. Following the sale of a large number of funds to institutional investors between 2016 and 2021, new investment fund strategies have deepened their focus on Dutch housing and parking garages in Europe. Within the residential segment, the company targets housing for young professionals and residential concepts for seniors including assisting living. It collaborates closely with various residential healthcare operators and real estate developers, including Long at Home Investments, a spin-off of Holland Immo Group which develops assisted living concepts and invests in healthcare providers. A team of 30 professionals manages the portfolio of approximately €0.9 billion in investments.
https://www.hollandimmogroup.nl/

redpajama_set_name: RedPajamaCommonCrawl


The main gym floor has been completed and looks beautiful. A minor correction will be made to the "CC" logo.
Demolition work began this week at the entrance of the school including removing sidewalks and digging a trench across the street to put in a new water main.


text:
Q: How to get from $\frac{1}{2\pi}\frac{e^{jn}-e^{-jn}}{jn}$ to $\frac{1}{2\pi}\int\limits_{-1}^{1}e^{j\omega n} d \omega$? How to get from:
$$\frac{1}{2\pi}\frac{e^{jn}-e^{-jn}}{jn}$$
to:
$$\frac{1}{2\pi}\int\limits_{-1}^{1}e^{j\omega n} d \omega$$
as given here:
https://dsp.stackexchange.com/a/38854/16003

A: The antiderivative of $e^{j\omega n}$ is $\frac{e^{j \omega n}}{jn}$ (as long as $n \neq 0$) and so by the fundamental theorem of calculus
$$ \frac{1}{2\pi} \int_{-1}^1 e^{j \omega n} \, d\omega = \frac{1}{2\pi} \left[ \frac{e^{j \omega n}}{jn} \right]_{\omega = -1}^{\omega = 1} = \frac{e^{jn} - e^{-jn}}{2\pi j n}.$$

redpajama_set_name: RedPajamaStackExchange


text:
Boris (;  1114 1154), also known as Boris Kalamanos (, Russian & Ukrainian: Борис Коломанович) was a claimant to the Hungarian throne in the middle of the . He was the son of Euphemia of Kiev, the second wife of Coloman the Learned, King of Hungary. After Euphemia was caught in adultery, Coloman expelled her from Hungary and never acknowledged that he was Boris's father. However, Boris, who was born in the Kievan Rus', regarded himself as the king's lawful son. He laid claim to Hungary after Coloman's firstborn and successor, Stephen II of Hungary, died in 1131. Boris made several attempts to assert his claims against kings Béla II and Géza II with the assistance of Poland, the Holy Roman Empire and the Byzantine Empire, but failed and was killed in a battle.

Early life

Boris was the son of Euphemia of Kiev, a daughter of Vladimir II Monomakh, the future grand prince of Kiev. She was given in marriage to King Coloman of Hungary in 1112. However, as the Illuminated Chronicle narrated, she "was taken in the sin of adultery". After discovering her illicit relationship, King Coloman expelled his wife from Hungary. She fled to her homeland where she gave birth to Boris around 1114. He was named after St. Boris, one of the first canonized princes of the Rurik dynasty. King Coloman never acknowledged that Boris was his son. Boris grew up in the court of his grandfather, Vladimir Monomakh, in Kiev.

A group of aggrieved Hungarian lords elected "Counts Bors and Ivan" king when Coloman the Learned's son and successor, Stephen II of Hungary, fell ill around 1128, according to the Illuminated Chronicle. However, Stephen II who regained his health ordered the execution of Ivan and expelled Bors who went to the Byzantine Empire. According to a scholarly theory, Count Bors was identical with Boris Kalamanos, but this theory has never been widely accepted. Stephen II died on 1 March 1131 and his cousin, Béla the Blind, succeeded him. At an assembly in Arad, the new king's wife, Helena of Rascia, ordered the massacre of all Hungarian lords whom she suspected of having been opposed to her husband's ascension.

Attempts to seize Hungary

First attempt

After Stephen II's death, Boris "laid claim to his father's kingdom" and went to the Byzantine Empire, according to the contemporaneous Otto of Freising. The Byzantine historian John Kinnamos said that Emperor John II Komnenos "accorded [Boris] sufficient honor and united him in marriage with a bride of his own family". However, Boris left the Byzantine Empire for Poland because the emperor did not provide him military assistance, according to Otto of Freising.

Boleslaus III of Poland was willing to assist Boris, because he wanted to set up a coalition against the Holy Roman Empire. Hungarian refugees and troops from the Kievan Rus' also joined Boris. Their united army invaded Hungary in the summer of 1132. Against them, Béla the Blind allied with Leopold III of Austria. The Hungarian lords who were loyal to the blind king massacred all lords who did not openly refuse Boris's claim to the throne. In the ensuing battle, the united Hungarian and Austrian troops routed the army of Boris and his allies on the banks of the Sajó River on 22 July. Béla's victory was decisive: Boris made no further attempts to seize the throne during Béla's reign, although his ally, Boleslaus III of Poland, made peace with Béla only in August 1135.

Second attempt

Boris visited Conrad III of Germany, accompanied by Conrad's brother-in-law, Vladislaus II, Duke of Bohemia, in late 1145. He complained  in "tearful and mournful tones" to Conrad that he had been deprived of his patrimony, begging Conrad to assist him in seizing Hungary, according to Otto of Freising. Vladislaus II and his wife, Gertrude of Babenberg, who supported Boris's claim, persuaded Conrad to let Boris recruit mercenaries in Austria and Bavaria.

Boris's mercenaries stormed into Hungary and captured Pressburg (now Bratislava in Slovakia) in April 1146. Géza II of Hungarythe son and successor of Béla the Blindsoon marched to the fortress and imposed a blockade on it. Géza entered into negotiations with Boris's mercenaries and bribed them into surrendering the fortress without fight. In retaliation for Boris's support, Géza invaded Austria and defeated the army of Henry Jasomirgott, Duke of Bavaria, in the Battle of the Fischa on 11 September 1146.

Third attempt

In Christmas 1146, Conrad III declared that he would lead a crusade to the Holy Land. Boris decided to join the German crusaders to come to Hungary. However, Géza II, who was informed of Boris's plan, "poured out much money among the Germans", persuading them to refuse Boris, according to Odo of Deuil. Boris did not give up his plan, because he was informed that many Hungarian noblemen "would take him for their lord and, deserting the King, would cleave to him" if he managed to return to Hungary, according to the Illuminated Chronicle.

He approached Louis VII of France, who was also marching across Central Europe towards the Holy Land, emphasizing his hereditary right to the Hungarian throne. After Louis VII did not answer his letter, Boris persuaded two French lords to help him to secretly join the French crusaders' army who entered Hungary in the summer of 1147. After discovering that his opponent was hiding among the French, Géza II demanded Boris's extradition, but Louis VII granted asylum to Boris and refused to hand him over to Géza II, most probably because Boris's wife was related the Byzantine Emperor, Manuel I Komnenos, according to historian Ferenc Makk. Nevertheless, Boris left Hungary for the Byzantine Empire together with the French crusaders.

Last years

After all his attempts to seize Hungary failed, Boris settled in the Byzantine Empire. During a war between the Byzantine Empire and Hungary in the late autumn of 1150, Boris fought in the Byzantine army. Upon Emperor Manuel's order, he pillaged the region of the Temes River at the head of a Byzantine army and forced a small Hungarian troop to flee. He only withdrew from Hungary after Géza II came to the frontier at the head of the royal army.

Boris died in 1153 or 1154. Otto of Freising said that Boris "was struck and killed by an arrow [from the bow] of a certain Cuman" while fighting against Hungary not long before 1156. On the other hand, the Byzantine historian, Niketas Choniates, wrote of "a certain Kalmanos" who "received a fatal wound and quit this life" in a battle against the "Scythians"Pechenegs or Cumanswho raided the Byzantine territories along the Lower Danube some time after Emperor Manuel's campaign of 1150 against Hungary.

Family

Boris's wife was a niece of Emperor Manuel I Komnenos, according to Odo of Deuil, but her name and family are unknown. Historian Raimund Kerbl says that she was identical with Anna Doukaina, because she styled herself kralaina ("queen") in a charter, issued in September 1157. She adopted the monastic name Arete after her husband's death. Boris married his Byzantine wife before he went to Poland in late 1131 or early 1132, because Otto of Freising mentioned his marriage before that event.

Boris's first son, sebastos Konstantinos Kalamanos, was the Byzantine governor of Cilicia between 1163 and 1175. Historian Makk identifies one Stephen, who was the cousin of the dethroned Stephen IV of Hungary, according to Kinnamos, as Boris's younger son. Neither Konstantinos nor Stephanos made attempts to seize the Hungarian throne.

Annotations

References

Sources

Primary sources

Deeds of John and Manuel Comnenus by John Kinnamos (Translated by Charles M. Brand) (1976). Columbia University Press. .
O City of Byzantium, Annals of Niketas Choniatēs (Translated by Harry J. Magoulias) (1984). Wayne State University Press. .
Odo of Deuil: De Profectione Ludovici VII in Orientem: The Journey of Louis VII to the East (Edited with an English Translation by Virginia Gingerick Berry) (1948). Columbia University Press.
The Deeds of Frederick Barbarossa by Otto of Freising and his Continuator, Rahewin (Translated and annotated with an introduction by Charles Christopher Mierow with the collaboration of Richard Emery) (2004). Columbia University Press. .
The Hungarian Illuminated Chronicle: Chronica de Gestis Hungarorum (Edited by Dezső Dercsényi) (1970). Corvina, Taplinger Publishing. .
The Two Cities: A Chronicle of Universal History to the Year 1146 A. D. by Otto, Bishop of Freising (Translated in full with Introduction and Notes by Charles Christopher Mierow, Ph.D., LL.D., President of Colorado College, Edited by Austin P. Evans and Charles Knapp) (1928). Columbia University Press.

Secondary sources

1110s births
1150s deaths
12th-century Hungarian people
12th-century Byzantine people
12th-century Rus' people
Pretenders to the Hungarian throne
12th-century Eastern Orthodox Christians
People from Kyiv
Byzantine military personnel
Deaths by arrow wounds

redpajama_set_name: RedPajamaWikipedia


text:
Joseph Robbins Kinney Millen (J.R.K.), was instrumental in the formation of the Navy League Cadet Corps in Canada.
J.R.K. Millen and the #7 J.R.K. MILLEN Navy League Cadet Corps
J.R.K. Millen was born about 1886 in Yarmouth, Nova Scotia to William Millen and Carrie D. Kinney. He was a professional in the Insurance field and started his career with the Insurance Department of Canadian Pacific Railways. He remained with the C.P.R for sixteen years before moving to Western Canada. Arriving in Winnipeg in 1921, he was associated with Osler, Hammond, and Nanton in the insurance department where he remained until his death.
Always interested in the well-being of and working with boys, he was an active official of the Knowles Boy Hostel (later named the Knowles School for Boys, and today known as the Knowles Centre), and interested in the work of the Sir John McDonald Hostel.
J.R.K. Millen's involvement with the Winnipeg Navy Sea Cadet Committee started in 1924 and in 1926 he became Commanding Officer of the Corps. During the Great Depression of the 1930's he personally helped many Cadets and ex-cadets find employment. During the Second World War he was responsible for the expansion of the Sea Cadet program. One of his responsibilities included being commissioned by the Canadian Government to co-ordinate all sea cadet corps in Canada and to build a proper relationship between the cadets and the Royal Canadian Navy. In the late 1940's he was a member of the Navy League Committee responsible for creating what is now known as Navy League Cadets.
He was surprised on the evening of 25 May 1960 while attending the inspection of Navy League Cadet Corps #7, when Mr. R.J. Bicknell, National President , announced that the corps was now officially named N.L.C.C. #7, J.R.K. Millen.
A tireless and unselfish supporter of the youth of Canada, he continued as a senior member of the Navy League until his death. J.R.K. Millen died suddenly on 25 October 1962 at his residence in Winnipeg. His funeral service was held at Knox United Church with many Navy League members in attendance. He was interred at Brookside Cemetery. For J.R.K. Millen, the formation of the Navy League Cadet Corps in Canada was one of his greatest achievements.
Mrs. Violet Millen, his widow, passed away at Central Park Lodge, Winnipeg in September of 1975
– Adapted from J.R.K. Millen: A Brief History,compiled by Mrs Ann Jackson, 2009
In the beginning of the sea cadet movement the Navy League of Canada had sole responsibility of running the Sea Cadets. At that time the age of cadets ranged from 12 to 18 years. The Government took over the responsibility of running the Sea Cadets, and the age of admission was raised to 14 years, and then later dropped to 13 years.
J.R.K. Millen of Winnipeg and the Navy League thought that there should there should be a similar type of organization for younger boys between the ages of 12 to 14 years. The Navy League Cadets that were formed out of this idea later changed the age of acceptance to 11 and 13 years of age. Today the age of entry to Navy League Cadets is 9 years and cadets may continue the age of 12 years.
What was to become #7 J.R.K. Millen N.L.C.C. was formed 1 Jan 1954, and has been running continually since. The Navy League has been carrying out its youth movement for over 90 years. Under the leadership of public-spirited Canadians, the movement continued – first as the Boys Naval Brigade, then as the Navy League Cadets.
A similar type of corps was formed for girls of the same age, which was called Centennial Navy League Wrenette Corps in Winnipeg. Centennial Wrenette Corps continued until September 1997 when it was disbanded.
Today, both male and female cadets parade with #7 Navy League Cadet Corps J.R.K. Millen.
For a complete history of the Navy League of Canada go to:
http://www.navyleague.ca/en/about-us/our-history/
Navy League Dates of Note 1895 – First Canadian Branch formed
1910 – Canadian Navy established
1914 – Recruiting and Welfare Services, World War I
1917 – First Canadian Boy's Naval Brigade formed
1918 – Federal Charter approved establishing the Navy League of Canada
1923 – Boy's Naval Brigade name changed to Sea Cadet Corps
1939 – Welfare Services, World War II
1941 – Canadian Navy became partner in the Sea Cadet movement
1942 – King George VI agreed to be Admiral, Royal Canadian Sea Cadets
1943 – Scholarship program introduced
1948 – Navy League Cadet program established
1950 – Navy League Wrenette program established
1995 – The 100th Anniversary of the Navy League of Canada
1997 – Last Navy League Wrenette Corps closed (NLWC Centennial in Winnipeg)


text:
Недото́рканий — той, якого ніхто не торкався, не чіпав тощо; перен. непорочний, чистий, цнотливий.

Недото́ркані (парії) — варна традиційного індійського суспільства.

Фільми, телесеріали

 Недоторканні (фільм, 1987)
 Недоторканні (фільм, 2011)
 Недоторкані (телесеріал)

Див. також
 Недоторканність (значення)

Примітки


Dedicated to further the health of dancers, Park View Pilates, is a member of the International Association of Dance Medicine (IADM). Safety in movement is important in everyday life, but even more in the life of a dancer. Enhancement of health, well-being, and performance of all types of dancers is offered though our safety in movement for dancers program.
The Pilates Center is an internationally renowned Pilates studio that is committed to teaching the classical method. Two sisters, Amy Taylor Alpers and Rachel Taylor Segel, are the owners of The Pilates Center. They trained under Romana Kryzanowska, Joseph Pilates' protege and inheritor of his studio in NYC. They founded their studio in Boulder in 1990. These women make it their mission to heal the world by teaching Pilates, and their passion and commitment to maintaining the integrity of the classical method inspires others to become teachers. Their Pilates teacher training program is referred to as the "Harvard of Pilates Schools".
The PMA is a non-profit professional association dedicated to the teachings of Joseph H. and Clara Pilates. It is a certifying agency for Pilates teachers.
Supports the world's leading health and fitness professionals with credible information, education, career development and leadership.


text:
The Return Home
by Conleth on Tue Apr 09, 2019 8:14 am
On the slow ride back to Minas Tirith Eldarion barely spoke to anyone. Since the last day of the battle he had descended deep into a sulky silence that prompted his men to give him a wide berth and keep their counsels as brief as possible. Eldarion understood why his father asked him personally to lead their troops and take over commanding the entire army. Eomer would have allowed those who fled to leave. Elessar had given specific orders to Eldarion to not let a single Northman or Easterling to return home. To take no prisoners or wounded and to once and for all to crush them utterly. Elessar was beyond furious with what was done to Nauriel. And the attempts at others of their family. In truth Eldarion himself felt, at times as his father did but being there...giving those orders and seeing them carried out made a hole open wide into the pit of his stomach. Part of what made him human died somewhere out there on that battlefield. And during the ride back he wondered if that was just part of being a King.
Perhaps a King was not human. He had to be above human concerns. He had to judge with impartiality, punish without compassion and show compassion when anyone else would not. To rail against his emotions and do what must be done. 'Help me Calista!' He cried silently as the white walls of the city came into view. As the watchers high up in the towers saw them the silver horns blew and bells to announce their coming rang out through the city.
Elessar was at court next to Nauriel as they sat on their thrones. The nobles hall was filled with petitioners for the day and Laenaya and Ariana sat to Nauriel's right and back a few feet as they looked on and played with Elfwine. As of late Elessar wanted Elfwine to become familiar with being at court for someday he may be called to act in the King's stead.
Eldarion pulled ahead of his men as it was customary to lead Gondor's forces in through the gate. People began to mass on the sides of the streets and jockeyed for position alongside the wall guards to get a good view of the procession. The wind was moderate today and the sky was a light gray and overcast. The banners fluttered lightly in the mild winds and Eldarions charger pranced through the gates.
"Clear the room the Prince has returned!" Elessar boomed and nobles bowed or curtsied and began filing out of the throne room. "Ariana...Laenaya, please go and greet your brother," He asked as he twisted to look at them. "Take elfwine if he wishes to come," He added and Elfwine stood up excitedly.
Re: The Return Home
by XslvrstarX on Tue Apr 09, 2019 10:01 am
Calista worried constantly about her husband. She had not heard from him for a few weeks and knew that there had been a very large battle that had taken place recently. In that battle the Northmen and Easterlings had been completely and utterly defeated and she had heard that Kressara and her new husband, Boarden, had been there as well. No word had reached her of whether Eldarion was unhurt or not and she was not sleeping well because her dreams were filled with nightmares of him being brutally killed while she tried to reach him in time.
She was not at court that morning. She was instead spending the morning with her twin sons, Cassian and Alistair. They were two years old at this point and were growing every day it seemed. They were old enough now to start getting into some trouble and needed to be vigilantly watched by herself or their nanny. She was sitting on the floor playing blocks with them when she suddenly heard the trumpets announcing the arrival of the soldiers. Calista jumped to her feet and called for the nanny. She told her to watch the boys while she went out to find her husband. She was wearing a light blue dress today and put on the matching cloak. Her blonde hair was half pulled back and spilled in soft curls down her back.
As she was rushing outside she nearly ran into Ariana, Laenaya, and Elfwine who were going to greet their brother. Calista and the others stood in front of the palace with guards on either side and behind them. Calista heard the crowd's cheers and applause grow louder as the soldiers neared the top of the city. As he came around the corner on his horse Calista could not stop the tears that started to stream down her cheeks. She wanted to rush into his arms, but she impatiently waited for him to dismount his horse and approach her.
by Conleth on Tue Apr 09, 2019 11:48 am
Eldarion smiled when he saw who was there waiting for him. Calista, just seeing her was like a drop of water in a desert to a man dying of thirst. He wanted to run to her, wrap his arms around her and let the world leave them be for a time. Forever if he had his way. Stablemen stopped his horse and took hold of the horse's reins. Eldarion dismount but then stumbled when he landed wrong on his injured leg. A chorus of 'Ohhh!' from those that saw made the women's eyes grow large in surprise and worry. Obviously Eldarion had been injured. He recovered smoothly and grinned a fake grin as he handed his reins to the man who held his horse. Once he cleared the animal's head the women, Calista and his sisters followed by Elfwine moved to embrace him. They all rained kisses and hugs down upon him and they all stood there a moment with his head over Calista's shoulder. Elfwin stood smiling up at them all though he definitely didn't want to wade into any of that. He might get kissed and girls were...icky. Well, besides Asterin maybe. She wasn't so icky. A few of Eldarion's tears fell upon Calista's neck and dampened her dress at the shoulder. That was very unlike him and he as he lifted up from her he surreptitiously wiped his tears away. 'God no...keep it together man!' He scolded himself. "I've missed you my love," he said and he kissed her passionately on her lips. The act made Elfwine cringe and his sisters smile approvingly. "Is mother and father at Court?" He asked briskly but felt Calista try to disengage from him. His arm clamped down around her waist though and held her close to him. Partly because her presence helped him keep himself together and partly because walking on his injured leg HURT.
by XslvrstarX on Tue Apr 09, 2019 1:01 pm
Calista's heart was beating quickly in her chest as she watched her husband. All she wanted to do was to feel his arms around her and to know that he was alright. As he dismounted his horse she saw him stumble slightly and her eyes widened and she gasped softly. Her first instinct was to run to him, but she forced herself to wait until he was ready. She followed Laenaya, Ariana, and Elfwine as they moved to embrace their brother and as she put her arms around him a few tears slipped down her cheeks. She looked up into his eyes and thanked the light that he had returned to her. As he kissed her she closed her eyes and kissed him back, not caring that everyone was watching. "I've missed you too m'love...so much," she said softly to him as they broke the kiss. "Yes, your parents are at court. They will be anxious to see you." She tried to step away from him, but felt him pull her back against him and realized he needed her help to walk on his injured leg. She let him keep his arm around her in what appeared to be an affectionate manner and walked with him inside with the others.
Nauriel was waiting anxiously for her son to appear. She had spent countless nights awake worrying about both he and Kressara. When the doors finally opened and he walked in a few tears came to her eyes. She immediately got up and walked quickly over to him. Calista stepped away for a moment as Nauriel wrapped her arms around him. "Thank the light you are safe," she whispered to him as a few tears slipped down her cheeks.
by Conleth on Tue Apr 09, 2019 2:57 pm
Eldarion didn't want to let go of Calista but what could he do when his mother came at him. He tried not to flinch at her embrace and he managed to only just stiffen a little. He relaxed into her right after with some effort and her worry over him brought up that all to familiar sense he had like his father to protect her. Her, his sisters and his family. 'Oh mother!" Eldarion whispered back and held her hard to him. He had tried to just be happy she was going to live. But now, with what he had done all his former worry for her came out of him and Eldarion, Prince of Gondor wept in his mother's arms.
When he finally calmed himself down with the help of the women who crowded around him and murmured soothing words to him and tried themselves to no avail, to stop their tears from falling, Eldarion produced the letter that Kressara had given him to deliver.
"This is from Kressara. In it there is a recipe that may help with your recovery from the Whitesnake Root poison. It is from her husband Boraden," He said uneasily as he pressed the letter into her hand. "Kressara is doing well mother. Her leadership won the day in the end," He added to make certain they knew how large a role she had played in the battle.
Nauriel held tightly to her son and let him cry in her arms. Having been through epic battles herself and seen death all about her she knew exactly what he was feeling. For someone who had never experienced it it could never truly be understood. He would carry those experiences with him for the remainder of his life. It didn't matter how old any of her children got. They would always be her children and she would always care and worry about them.
As he put the letter into her hand and told her about Kressara she felt fresh tears come to her eyes. She had been hoping that she would be with Eldarion. She had not seen her youngest daughter in so long. She was immensely proud of them both.
She looked at the letter and then glanced at her husband. She took a few steps back to let Elessar greet and embrace him and a few quiet words were exchanged. It was then that Nauriel noticed how her son was standing.
"You're hurt. Should I fetch the healers?"
Eldarion felt like groaning and saying yes but what he said was. "Perhaps later, father," he began and let go of his father's arm and gestured for Calista. He needed her warmth and love and touch even now. "Father I did as you commanded. Kressara and I both did. We defeated them...we...killed them all," he said and tried to keep the horror of it out of his voice. "Perhaps a few made it into the trees but our scouts could find no one but the Northman and the Woses are excellent at trail craft," he said and was relieved when he was able to wrap his arm around her. He thought that she lost a little weight but didn't say anything right then.
"The...camp followers too. Since their women also fight alongside the men. We destroyed their camp and took no prisoners. We let those that looked to young go but the rest...as I said, we destroyed them," he said almost bitterly. His two sisters faces looked pale and Ariana looked as if she might sick up upon hearing all of this. "I did that mother...For you, for us all. They had the majority of their fighting men in that valley and our armies...Rohan's and Gondors wiped them out. Our butchers bill is not insignificant but on open ground like that...with pikes, archers, heavy infantry and horse...they didn't stand for long," he said hoping that his report was sufficient. He really didn't want to talk about it anymore.
"You did well son...now get some rest. We'll," He began then Eldarion shifted forward to grab his arm.
"Are we done then?" Eldarion said almost desperately and his face and eyes were all grim concern. "The Haradrim...the Northman...The Easterlings and the Wose. We've killed them all...Have we done enough?" He asked and Elessar turned back and put his hand over Eldarions "Yes Eldarion, We tried the carrot and now the stick. We are done," he said and shook his hand once then turned and stepped back toward his throne. Eldarion gave a pained look at Nauriel as if he was hoping for more...
Calista led her husband back to their apartments. She was worried about him, but she didn't say anything. As they walked in the nanny immediately curtsied and Cassian and Alistair ran over to their father. "Daddy! Daddy!" they exclaimed as they hugged his legs. Jayne, their maid walked in and Calista looked at her.
"Jayne, please prepare a hot bath for Prince Eldarion."
"Yes, M'lady," Jayne said as she curtsied. She then walked into the private bath to draw the water.
"Are you sure you don't want a healer to come and look at you?" Calista asked, no longer able to hide the worry in her eyes.
Nauriel still held the letter from Kressara in her hands, but she wasn't focused on that at the moment. She slowly walked over to her husband, knowing that he was processing everything. She took her seat beside him and reached out and took his hand before looking at him. "You need to talk to him. You understand what he's going through and he looks up to you."
Elessar sat at an angle on his chair and thought about what Nauriel had said. Laenaya was there as well and had a thoughtful look upon her face. Ariana has taken Elfwine back to his rooms and she had to get back for Meliara.
"Father Eldarion seemed...troubled we may have peace from what Gondor has done but at what cost? Have we made enemies now? What happens when the Haradrim and the Northmen rebuild their armies. What happens then? More war?" She asked thoughtfully. "Have we become the Orcs and trolls of middle earth?" She asked truthfully. And she looked as if she really wanted to know.
"Ofcourse not!" Elessar snapped. "We've become too complacent and the chaotic factions of middle earth daughter to pick us apart like diseased crows. Well I've shown them the folly of that line of attack. If the nations of this world do not choose peace, peace will be forced upon them!" He said a little too loudly and his voice echoed through the hall.
"At what cost father? At what cost?" Laenaya repeated and Elessar did most choose to answer her.
Eldarion sat on his bath and told Jayne to leave him and he asked Calista to talk with him. Though that was just an excuse to keep her close. He need distractions. Anything to keep his thoughts away from what he had seen and done.
Nauriel wanted some time to speak to Elessar alone and she looked over at Laenaya. "Why don't you go and check on Calene."
Laenaya sighed softly and nodded and curtsied before leaving. After she was gone Nauriel sat there a moment before looking at her husband. "She didn't mean what she said. We've all just been through a lot with this war. There has been constant worry and stress for us all, but none so much as you. You did what you had to M'love and once the dust settles peace will return."
Calista had the nanny put the twins down for a nap and she prepared some tea for Eldarion the way he liked it. After he was settled in the tub she brought it to him and pulled up a chair to sit next to him. She could tell he didn't want to talk about the war so she decided to fill him in on everything else.
"Calene and Kaled are here visiting. They will be here for another week or so before going home. Oh, and both she and Laenaya are pregnant."
Eldarion looked up at Calista and accepted her offering of tea. "More babies...mother must be pleased," he said as he blew on the tea to cool it but his hands were shaking so badly he had to hand it back. "I'm...not myself dearest," he began then touched his forehead. "No...I should not speak of it," Eldarion said. "The boys...they look well...I am pleased. The future of our family...you've made me so happy Calista...I love you so much. I...I should tell you that more," he said.
"We should make an effort to see Calene and Kaled, can we set that up?" He asked but it was as if he were just repeating what he had heard and not really caring about what he said.
"No… I think she did. She worries that the world we made today will make it more difficult to be trusted in the future. But What choice did I have? I will no see my family...you killed...murdered from some misguided sense of honor. Let the nations of middle earth know Gondor's might. For today and tomorrow," Elessar said. "You are my life Nauriel. And I will not lose you" he said angrily.
Calista saw how badly his hands were shaking and she took the cup of tea back and put it down. It broke her heart to see her husband like this. She desperately wanted to help him, but she didn't know how. She thought for a moment before she got up and began to disrobe. She left her hair down and then stepped into the tub to join him. She felt his arms envelope her and she wrapped her arms around him and rested her head upon his shoulder.
"I love you so much," she whispered to him. "Whenever you are ready to talk...if you ever want to talk about it...I am here for you M'love."
Nauriel decided not to speak anymore about it. What was done was done and she believed the world would be better off for it. It had been difficult and harsh, but Elessar was right in that Gondor had become complacent with peace. They had let their guard down and that would not happen again. She would ensure that their family and people were kept safe.
She handed Elessar the letter that Kressara had given to Eldarion. "Kressara gave this to Eldarion. It apparently contains a recipe that can reverse the effects of the Whitesnake Root."
Father and Mother,
Please use the recipe at the end of this letter. It is an antidote for the white snake root poison provided by my husband Boraden. I wish you could meet him and we fully intend on coming to Minas Tirith. I now believe that regardless of how he was raised. He is of our blood, the blood of the Dunedain. And we need to help him find where he came from.
As Eldarion likely told you the armies of the North have been completely destroyed. But it was not without a cost. Particularly with Eldarion. Please help him find his way back from the dark place he has gone.
Your loving daughter,
Kressara
The feel of Calista against him was amazing. She was so warm and soft and wonderful. He had missed this and he needed her more than he needed anything in his life right then. "Make love to me Calista. I need to feel you…" he whispered. His leg still hurt be he knew he need that more right then.
Both Nauriel and Elessar read the letter and just hearing from Kressara made them both very happy. "I still can't get over her marrying. The impulsiveness of our daughters...is likely to send me to an early grave wife. Perhaps Inshould have put locks on their doors," Elessar said jokingly but there was a hint of regret in that as well.
by XslvrstarX on Tue Apr 09, 2019 10:06 pm
Nauriel felt both a wave of sadness and a feeling of pride come over her as she read the letter from Kressara. Kressara was truly no longer a child. She was a strong, independent woman with a great destiny still to be fulfilled. She was honored to have her as a daughter, as she was honored to be the mother to all of her children.
Nauriel gave her husband a small smile as she carefully folded back up the letter. "They get that from us you know. I was impulsive in leaving Gehenna with you when I didn't even know you and you were impulsive in asking me to go with you." She eyed him a little. "Or were you...? You know I've always gotten this feeling that you were sent to Gehenna to find me. Did Galadriel send you?"
by Conleth on Wed Apr 10, 2019 8:07 am
Elessar only stared at her for a while before he spoke. "She did send me. She said that I had a choice to make and it had to do with Gehenna," He said then thought on that for a few moments as he began to remember back. "Up until the moment I met you, I was destined to marry Arwen. I had left Rivendel to prove my worth to her father Elrond. In some ways I suppose I did prove myself. But I also grew apart from Arwen. I had...broken oaths to be with you. But I have no regrets," He said honestly. "Now that I think about it, I feel that Galadriel had known all along what would happen," he said and chuckled. "She had summoned me early that morning and if I hadn't stopped to talk to Haldir I would have already left," he said as he recalled that moment and smiled as he looked at his wife. He approached her and then kissed her like he had many times before. A passionate, loving kiss that lingered as she kissed him back. Elessar's eyes were filled with desire for Nauriel and he hoped that she would fully recover from her illness.
Eldarion laid next to Calista and held her up to him. He felt her breasts up against his chest and she reached up to twist his hair between her fingers. His hair was damp with sweat and he had been unusually aggressive with her in their love-making. Red runnels ran up and down her arms, her sides and her back and she was damp from sweat as well. He kissed her lips softly and buried his face into her hair and neck. "I lost something...out on that battlefield," He said in little more than a whisper. "I did...terrible things. Had men and women who fled cut down like dogs," he said and shifted away from her to lay upon his back and stare up at the ceiling. "I can't blame my father for what I did. He wasn't there. There is only me," He said as his eyes filled up with tears.
by XslvrstarX on Wed Apr 10, 2019 8:48 am
Nauriel closed her eyes and returned her husband's kiss. They had been through more than any other living couple in Middle Earth...they understood one another without the use of words. Her soul was so deeply attached to Elessar's that it was as if she could feel it flowing through herself. No one else would ever truly be able to understand what a love like theirs felt like. It was pure and deep and passionate.
"Galadriel spoke to me just before I left Lothlorien to return to Gehenna with Beren. She spoke to me privately and she said when I got to Gehenna to remain there and wait for my heart and destiny would meet me there. I never understood what she meant until the day you and I married."
Calista lay entangled in Eldarion's arms on their bed. They were damp from the tub and from the sweat that glistened on their bodies. The sun was still shining outside, but it was getting lower in the sky as it became late afternoon. She felt Eldarion bury his face into her hair and she held him a little tighter as she began to listen him. It was clear that he was suffering from great guilt over what he had done and Calista was at a loss of how to help him. She knew deep down that only time would heal this wound...and perhaps it would never heal entirely.
"You saved the lives of your family Eldarion and your people," she whispered back. "The men and women who were there on that field made the choice to be there and I know that had they had the chance that they would have killed you without a second thought. War is a dirty thing, but it is over now....because of you. There were hundreds of people cheering for you and chanting your name today. It's over and now we can be a family again."
by Conleth on Wed Apr 10, 2019 11:53 am
Eldarion's heart began to race and his cheeks colored in obvious agitation. He retained his calm, it was not easy to remain calm but he knew it wasn't Calista's fault. None of it was anyone's fault but his own. The guilt of it darkened his heart down into his very soul. He did feel like taking it out on her...on anyone...everyone in an attempt to cleanse the darkness that threatened to consume him. He took in a deep breath and took in the scent of her hair. Rose petals, herbs and that sweet smell that was just her.
"It is false to cheer me. It is because they do not know. All they know is that their Prince went to fight and he was victorious. But I know how that victory was won. We did win justly but once we did the horror that came after...I did nothing to stop it. I ordered it and did nothing. I wanted them all dead. I needed it like I needed air to breathe. But after...when I saw them...and heard them pleading...I did nothing to stop it. Our people cheer me falsely. I am undeserving of it and the light knows what will come of this in the future. Instead of giving them mercy, I gave them a shameful death. One without honor," he said as he looked into her eyes. In that gaze Eldarion was not himself. He was someone else completely. Like a man who was drowning and pushed away the hands that tried to help him stay afloat.
"In the Harad...Kressara poisoned an entire village. There was no honor in that either but it allowed our forces to attack a weakened foe and crush them. There are not heroic deeds but acts of desperation. How did mother and father fight all those orcs and retain their honor? Where they succeeded we have failed," he said sadly. As he pressed his eyes closed tears squeezed out and ran down his cheeks.
Elessar had forgotten about Nauriel's odd...relationship with her brother. It was now like a relic of a memory that belonged long forgotten in his head. "I wonder why she took such an active role in the future like that. I can only assume that in her mind, one path was better than the other. Or at least, more favorable. I did love Arwen but that time apart from her was filled with you and that made all the difference," he said as he shifted to take hold of her her. He sat down onto his throne and let her come to rest on his lap, the skirts of her dress draped down to the floor around his feet. He buried his face in her neck and chest and kissed her neck and took in her scent. "I remember that day in the rain when we first made love," He said and she felt a stirring beneath her from where she sat. She could feel his face smile as he lightly planted kisses on her neck and jawline. It had been a very long time since he last dandled her on his knee like this. As if she were a young girl and he a boy and they were playing at kissing one another.
by XslvrstarX on Wed Apr 10, 2019 3:51 pm
Kressara felt a wave of emotion come over her as the White City finally came into view. It had been several years since she had been home and so much had happened since then. The biggest difference was that she was returning with her husband, Boraden. The war was over and she felt that they could give themselves a few months to relax and enjoy one another as a new husband and wife. They deserved at least that. She couldn't wait to show him through the city and to work on locating information about his family.
They were immediately let through the gates and because she hadn't been home in some time and because she was not wearing anything with the Gondorian royal seal on it she was not immediately recognized. A few people did stop and stare at her for a few moments though, wondering if it could possibly be her. As they reached the top of the city they were met by a groomsman who took their horses. Einor happened to present and did recognize her and she was thrilled to discover that he had married Ariana and that they had a son together named Airen. She introduced him to her husband and then looked at him.
"Are my parents presently at court or in their apartments?"
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CERN's neutron time-of-flight facility n_TOF has produced a considerable amount of experimental data since it has become fully operational with the start of its scientific measurement programme in 2001. While for a long period a single measurement station (EAR1) located at 185 m from the neutron production target was available, the construction of a second beam line at 20 m (EAR2) in 2014 has substantially increased the measurement capabilities of the facility. An outline of the experimental nuclear data activities at n_TOF is presented.


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1 Month Supply 64.95 US$
2 Month Supply 112.95 US$
SERRAPEPTASE - TRADITIONAL INDICATIONS
Sinusitis and Bronchitis
Infection and Atherosclerosis
Fibrocystic Breast Swelling
The Miracle Enzyme
Inflammation is nature's double-edged sword. Inflammation characterized by pain and swelling, is triggered as a healing response in the body when it is injured or attacked by negative bacteria and viruses. Once the body recovers, the inflammation goes away. However, for tens of millions of Americans, with disorders such as arthritis, sinusitis, bronchitis, fibrocystic breast disease, and carpal tunnel syndrome, the inflammation does not go away. Over 50 million persons in the United States are affected by arthritis, defined as a joint disorder featuring inflammation. More than half of those with arthritis are under 65 years of age. Inflammation of the sinuses, known as sinusitis, is one of the most common afflictions in the United States. Another form of inflammation is carpal tunnel syndrome which occurs when tendons in the wrist become inflamed after being aggravated and is experienced by millions of Americans. Obviously, the dark side of inflammation, inflammation that doesn't heal, that doesn't go away, is one of the most prevalent health problems today.
Dangers of Conventional Treatment for Inflammation
The conventional treatment for inflammation disorders also has a dark side - serious side effects. The two most common treatments for inflammation are steroids such as Prednisone and non-steroidal anti-inflammatory drugs, called NSAIDs, such as over-the-counter aspirin, ibuprofen (Advil, Motrin), ketoprofen (Orudis), naproxen sodium (Aleve), and over eleven prescription NSAIDs. According to the Mayo Clinic (www.mayoclinic.com), side effects of steroid treatment include weight gain due to disrupted metabolism, increased blood sugar, loss of bone, osteoporosis and joint damage, cataracts, thinning of skin, slow wound healing, high blood pressure, lowered immune system, emotional disorders, fluid retention, and suppression of normal adrenal function .
Many people know about the dangers of steroids and take NSAIDs to avoid the serious side effects associated with them. However, research studies published in the most prestigious medical journals point to the very serious side effects of NSAIDs as well. A statement from the July 1998 issue of The American Journal of Medicine states that "...approximately 107,000 patients are hospitalized annually for NSAID-related gastrointestinal complications and at least 16,500 NSAID- related deaths occur each year among arthritis patients alone." They went on to say that if the NSAID-related deaths for everyone taking these medications were calculated the figures would be overwhelming. The New England Journal of Medicine (June 1999) estimated that the number of deaths due to NSAIDs is similar to the number of deaths due to AIDS in the United States. Unfortunately, people have no warning that these drugs are causing them ulcers and internal bleeding until it is too late.
In addition to the side effect of internal bleeding, studies in the Archives of Internal Medicine (March 27, 2000) indicate that taking NSAIDs can double the risk of congestive heart failure.
Even more troubling is the study that indicates NSAIDs such as Naproxen and ibuprofen had toxic effects on cartilage metabolism and inhibited matrix synthesis. The medications people were taking for arthritis were actually contributing to the destruction of their joints! The problem with NSAIDs is not a small problem. There are approximately 33 million people taking NSAIDs in the United States today.
Drug companies introduced the Cox-2 inhibitors to replace NSAIDs and avoid their life-threatening side effects. At first glance, they looked like the answer to NSAID complications. However celecoxib (Celebrex) has its own list of side effects for osteoarthritis sufferers including headaches, changes in bowel habits, abdominal discomfort, dizziness, plus possible dangers to people with heart disorders, and the possibility of serious drug interactions.
Obviously, a safe, alternative treatment for people suffering from arthritis and other inflammatory disorders is
Alternative Treatment for Inflammation - A Miracle Enzyme
Fortunately, there is a natural alternative to steroids and NSAIDs that is effective without serious side effects. Serratiopeptidase or serrapeptase is a protein (proteolytic) enzyme isolated from the non-pathogenic enterobacteria Serratia E15 found in silkworms. It has been used successfully for almost 40 years in Japan and Europe for pain and inflammation due to arthritis, trauma, surgery, sinusitis, bronchitis, carpal tunnel and painful swelling of the breasts. There is some preliminary indication that it may be useful for atherosclerosis. This enzyme is absorbed through the intestines and transported directly into the bloodstream. However, if the enzyme is consumed in unprotected capsules or tablets it is destroyed by the acid in the stomach before it gets to the small intestine.
Therefore, to be effective, Serratiopeptidase must be enterically coated.
History of Enzymes as Anti-Inflammatory Agents.
Enzymes were first used as an anti-inflammatory in modern medicine in the 1950's when it was discovered in the United States that intravenous trypsin could relieve inflammation due to rheumatoid arthritis, ulcerative colitis, and atypical viral pneumonia as well as post-surgical swelling and bruises caused by sports injuries. Later, intramuscular injections were used. In 1957, the Japanese began using Serratiopeptidase for inflammation. Then, in the 1960s, researchers in the United States successfully used enterically coated protein enzymes such as trypsin and chymotrypsin or bromelain to administer enzymes orally. In Japan, researchers continued to focus on Serratiopeptidase for its anti-inflammatory activity. In the 1980's and early 1990's, Japanese and European research compared several of the protein enzymes and their study indicated that Serratiopeptidase was the most effective of all of them in reducing the inflammation response. Serratiopeptidase became widely used in Japan and Europe as the anti-inflammatory and pain treatment of choice. Serratiopeptidase for Inflammation
Soon Serratiopeptidase became a standard treatment in Japan, Germany and other European countries for the treatment of post-operative inflammation and traumatic swelling. It not only provided relief from pain and reduced swelling, but by the process of reducing the amount of fluid in the tissues, thinning the fluid, and helping the fluid drain out of the affected area, it helped speed tissue repair. In addition, its enzyme activity dissolved dead tissue surrounding the injured area so that healing was accelerated. It also was used in the successful treatment of fibrocystic breast disease to help reduce swelling and pain with eighty-five percent of the patients receiving the enzyme reporting moderate to marked improvement with no adverse reactions. Its obvious success in reducing inflammation and pain made it a candidate for treatment of other types of inflammatory disorders including rheumatoid and osteoarthritis, as well as sprains and torn ligaments.
Serratiopeptidase for Sinusitis and Bronchitis
Research and clinical use of Serratiopeptidase for sinusitis and bronchitis also proved successful. In both conditions, there is inflammation and swelling of the lining of the airways that prevent drainage of mucus. The airways then become even more obstructed. The mucus in these areas becomes thick and packed and thus is not easy to expel. This thick mucus pack also becomes a breeding ground for bacterial infections and more inflammation. Stuffy nasal passages and congested bronchial areas are often treated with antihistamines which dry up the mucus even more, making it even more difficult for the body to break up and expel. Antibiotics are also frequently prescribed for these conditions, often with little success. The thick mucus remains intact after antibiotic therapy and provides a breeding ground for more bacteria, and the patient begins an endless cycle of inflammation and antibiotics. Some of the drugs used to treat these problems deplete mucus, while Serratiopeptidase alters the elasticity of mucus without depleting it. Serratiopeptidase actually reduces the thickness and viscosity of the mucus and improves the elimination of it through broncho-pulmonary secretions.Patients treated with Serratiopeptidase for laryngitis and sinusitis experienced a significant reduction in severity of pain, rapid improvement of symptoms after 3-4 days, as well as reduction in nasal stuffiness, infected secretions, and fever.
Serratiopeptidase, Infection and Atherosclerosis
Other studies have shown that this enzyme can actually team up with antibiotics and deliver increased concentrations of antibiotics to the site of the infection. Bacteria can go through a process of producing biofilm, which results in resistance to antibiotics. A study by a team of Italian researchers suggests that proteolytic enzymes such as Serratiopeptidase could significantly enhance the effectiveness of antibiotics against biofilm and can inhibit biofilm formation. Serratiopeptidase has been shown to enhance the activity of several antibiotics including ampicillin, ciclacillin, cephalexin, minocylcine and cefotiam.
Another promising area is the use of Serratiopeptidase to break down atheroscleroticplaque. Hans A. Nieper, M.C. an internist from Hannover, Germany, studied the effects of Serratiopeptidase on plaque accumulation in the arteries. Because the enzyme digests non-living tissue and leaves live tissue alone, it may be effective in removing the deposits of fatty substances, cholesterol, cellular waste products,calcium and fibrin on the inside of the arteries. The fibrinolytic (clot removal) activity of Serratiopeptidase may also be able to help with thickened blood, increased risk of stroke, and phlebitis/thrombophlebitis.
Serratiopeptidase and Carpal Tunnel Syndrome
Carpal tunnel syndrome is an inflammatory disorder of the hand and wrist that is characterized by intense, long-lasting pain, inflammation and disability. The U.S. Dept. of Labor has stated that of all the occupational hazards, more days are needed to recover from this disorder than any other. Treatment has been by NSAIDs and surgery. In a promising small trial, Serratiopeptidase improved the inflammation and pain of carpal tunnel syndrome. Sixty five percent of the patients showed clinical improvement. No significant side effect was observed.
Serratiopeptidase Reduces Pain
Pain is one of the most troubling aspects of inflammation. Acute pain produced by cellular chemical reactions is part of the body's natural inflammatory healing response. Chronic pain, though, can be detrimental to healing. Swelling caused by inflammation can cause tissue to press against sensitive nerves and cause pain. Serratiopeptidase's ability to reduce and drain fluid from the inflamed area can reduce swelling and pain. However, Serratiopeptidase also reduces pain through its ability to block the release of pain-inducing amines from inflamed tissues. Unlike NSAID pain medications, Serratiopeptidase does not cause dangerous internal bleeding nor is it addictive like many pain medications.
How Does Serratiopeptidase Work?
When doctors first started using protein enzymes to reduce inflammation and pain they didn't know for sure how they worked. Now it is believed that Serratiopeptidase acts upon inflammation by thinning the fluids in the body that collect around injured areas and increases fluid drainage. This also enhances tissue repair and reduces pain. Pain is also reduced by the protein enzyme's ability to block amines. Serratiopeptidase also has the unique ability to dissolve the dead and damaged tissue that is a by-product of the healing response without harming living tissue. It is used in this way by the silkworm to digest a hole in the dead tissue of the cocoon so the silkworm can emerge. Serratiopeptidase also works by modifying cell-surface adhesion molecules, which guide inflammatory cells to their targets. These adhesion molecules are known to play an important role in the development of arthritis and other autoimmune diseases.
Practical Points
The recommended dosage for Serratiopeptidase is 10 mg to 30 mg a day. For arthritis, sinusitis, fibrocystic breast swelling, bronchitis, carpal tunnel syndrome, and cardiovascular problems, 20 mg a day. For pain, start with 10 mg daily and work up to 20 mg daily if needed. For injury, trauma or post-surgery recovery, take 30 mg daily for two days, then take 20 mg daily until swelling and pain subsides. Use only enteric coated tablets or capsules. Take Serratiopeptidase on an empty stomach, at least one half hour before eating or two hours after eating.
Serratiopeptidase has a remarkable record of safety from decades of use by millions of users in Japan and Europe, as well as documented use in over 40 clinical studies. There is some evidence of gastrointestinal irritation in elderly patients with use of the product over a long period of time, though this is rare. Because Serratiopeptidase thins mucus secretions, there is the slight possibility of increased risk of infection of the lung. This has been reported in letters to medical journals, but the incidence is very rare. It also acts as a blood thinning and clot-dissolving agent so patients on blood thinning medications should consult their doctor before using.
SERRAPEPTASE - DOSAGE and DIRECTIONS
Recommended Dosage and Directions: For Adults 18 ayrs or above, one (1) Capsule two times daily in empty stomach with lukewarm water.
For best results, no food should be taken 30 minutes before or after taking SERRAPEPTASE.
Take optimum water to enhance elimination of released toxins from the body.
SERRAPEPTASE - INGREDIENTS
serratiopeptidase 120,000 SPU *
SERRAPEPTASE - HEALING CRISIS
There is no Heling crisis.
SERRAPEPTASE - TESTIMONIALS
SERRAPEPTASE - HEALINGCRISIS


Online Computer Support Company, iRepair.net now brings new virus removal services, keeping in concern the specific needs of small businesses.
iRepair.net now brings new virus removal services, keeping in concern the specific needs of small businesses.
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All businesses today rely on search engine optimization for their success. It is no wonder businesses today are always in search of the best SEO strategies and tools to give them an edge over their competitors. Of Course, this may prove challenging when you are a start-up with no idea what SEO strategies are effective for your new site. Unfortunately, you need the rankings so as to drive targeted traffic to your website. No doubt the best SEO strategies should help you gain organic rankings over time, but what are these solutions and strategies. Luckily, there are so many simple yet very effective optimization solutions that can make a huge difference on this site you are trying to build. Continue reading to find more info. on the best SEO strategies and tools for your site.
Content is king, or so the saying goes; so always strive to provide superior quality content to your target audience. Statistics show that today's generation has the shortest attention span ever recorded in the history of mankind. Therefore, you must work at ensuring you provide superior quality content focused on the main theme of your site. Work at ensuring you have a high retention rate of your web visitors. No doubt a longer stay means high chances of them taking action. This you get to achieve by high quality, relevant content. You can try to create articles of between 1500 and 2500 words so that you can engage them.
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text:
WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia
Falshruti B. Patel, Martha Soto
Robert Wood Johnson Medical School (RWJMS), Pathology
Cells can use the force of actin polymerization to drive intracellular transport, but the role of actin in endocytosis is not clear. Studies in single-celled yeast demonstrate the essential role of the branched actin nucleator, Arp2/3, and its activating nucleation promoting factors (NPFs) in the process of invagination from the cell surface through endocytosis. However, some mammalian studies have disputed the need for F-actin and Arp2/3 in Clathrin-Mediated Endocytosis (CME) in multicellular organisms. We investigate the role of Arp2/3 during endocytosis in Caenorhabditis elegans, a multicellular organism with polarized epithelia. Arp2/3 and its NPF, WAVE/SCAR, are essential for C. elegans embryonic morphogenesis. We show that WAVE/SCAR and Arp2/3 regulate endocytosis and early endosome morphology in diverse tissues of C. elegans. Depletion of WAVE/SCAR or Arp2/3, but not of the NPF Wasp, severely disrupts the distribution of molecules proposed to be internalized via CME, and alters the subcellular enrichment of the early endosome regulator RAB-5. Loss of WAVE/SCAR or of the GEFs that regulate RAB-5 results in similar defects in endocytosis in the intestine and coelomocyte cells. This study in a multicellular organism supports an essential role for branched actin regulators in endocytosis, and identifies WAVE/SCAR as a key NPF that promotes Arp2/3 endocytic function in C. elegans.
https://doi.org/10.1016/j.ydbio.2013.03.012
Actin nucleation
Early endosomes
Nucleation promoting factors
10.1016/j.ydbio.2013.03.012
Fingerprint Dive into the research topics of 'WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia'. Together they form a unique fingerprint.
Endosomes Medicine & Life Sciences
Endocytosis Medicine & Life Sciences
Epithelium Medicine & Life Sciences
Caenorhabditis elegans Medicine & Life Sciences
Actins Medicine & Life Sciences
Clathrin Medicine & Life Sciences
Wasps Medicine & Life Sciences
Polymerization Medicine & Life Sciences
Patel, F. B., & Soto, M. (2013). WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia. Developmental Biology, 377(2), 319-332. https://doi.org/10.1016/j.ydbio.2013.03.012
Patel, Falshruti B. ; Soto, Martha. / WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia. In: Developmental Biology. 2013 ; Vol. 377, No. 2. pp. 319-332.
@article{05c809daa2ad470e860ee888aba30b6c,
title = "WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia",
abstract = "Cells can use the force of actin polymerization to drive intracellular transport, but the role of actin in endocytosis is not clear. Studies in single-celled yeast demonstrate the essential role of the branched actin nucleator, Arp2/3, and its activating nucleation promoting factors (NPFs) in the process of invagination from the cell surface through endocytosis. However, some mammalian studies have disputed the need for F-actin and Arp2/3 in Clathrin-Mediated Endocytosis (CME) in multicellular organisms. We investigate the role of Arp2/3 during endocytosis in Caenorhabditis elegans, a multicellular organism with polarized epithelia. Arp2/3 and its NPF, WAVE/SCAR, are essential for C. elegans embryonic morphogenesis. We show that WAVE/SCAR and Arp2/3 regulate endocytosis and early endosome morphology in diverse tissues of C. elegans. Depletion of WAVE/SCAR or Arp2/3, but not of the NPF Wasp, severely disrupts the distribution of molecules proposed to be internalized via CME, and alters the subcellular enrichment of the early endosome regulator RAB-5. Loss of WAVE/SCAR or of the GEFs that regulate RAB-5 results in similar defects in endocytosis in the intestine and coelomocyte cells. This study in a multicellular organism supports an essential role for branched actin regulators in endocytosis, and identifies WAVE/SCAR as a key NPF that promotes Arp2/3 endocytic function in C. elegans.",
keywords = "Actin nucleation, Early endosomes, Endocytosis, Morphogenesis, Nucleation promoting factors",
author = "Patel, {Falshruti B.} and Martha Soto",
note = "Funding Information: We would like to thank the NCRR -funded Caenorhabditis Genetics Center, Hanna Fares, Todd Lamitina and Barth Grant, for strains, the NICHD -funded University of Iowa Hybridoma Bank for the antibodies to DYN-1, IFB-2 and ERM-1, Jon Audhya for antibodies to RAB-5, Renaud Legouis for the antibody to LET-413, Zhiyong Bai and Barth Grant for the RT2287 strain, and Barth Grant for antibodies to CHC-1, RME-2 and APA-2, and for advice on endocytosis assays and staining of adult intestines. Thanks to Dr. Carolina Wahlby at CellProfiler (Broad Institute) for advice on quantitation. We thank Barth Grant, Loren Runnels and two anonymous reviewers for helpful suggestions on the manuscript. This research was funded by grants from the NIH ( GM081670 ) and NSF ( 0641123 ) to M.C.S.",
doi = "10.1016/j.ydbio.2013.03.012",
journal = "Developmental Biology",
Patel, FB & Soto, M 2013, 'WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia', Developmental Biology, vol. 377, no. 2, pp. 319-332. https://doi.org/10.1016/j.ydbio.2013.03.012
WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia. / Patel, Falshruti B.; Soto, Martha.
In: Developmental Biology, Vol. 377, No. 2, 15.05.2013, p. 319-332.
T1 - WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia
AU - Patel, Falshruti B.
AU - Soto, Martha
N1 - Funding Information: We would like to thank the NCRR -funded Caenorhabditis Genetics Center, Hanna Fares, Todd Lamitina and Barth Grant, for strains, the NICHD -funded University of Iowa Hybridoma Bank for the antibodies to DYN-1, IFB-2 and ERM-1, Jon Audhya for antibodies to RAB-5, Renaud Legouis for the antibody to LET-413, Zhiyong Bai and Barth Grant for the RT2287 strain, and Barth Grant for antibodies to CHC-1, RME-2 and APA-2, and for advice on endocytosis assays and staining of adult intestines. Thanks to Dr. Carolina Wahlby at CellProfiler (Broad Institute) for advice on quantitation. We thank Barth Grant, Loren Runnels and two anonymous reviewers for helpful suggestions on the manuscript. This research was funded by grants from the NIH ( GM081670 ) and NSF ( 0641123 ) to M.C.S.
N2 - Cells can use the force of actin polymerization to drive intracellular transport, but the role of actin in endocytosis is not clear. Studies in single-celled yeast demonstrate the essential role of the branched actin nucleator, Arp2/3, and its activating nucleation promoting factors (NPFs) in the process of invagination from the cell surface through endocytosis. However, some mammalian studies have disputed the need for F-actin and Arp2/3 in Clathrin-Mediated Endocytosis (CME) in multicellular organisms. We investigate the role of Arp2/3 during endocytosis in Caenorhabditis elegans, a multicellular organism with polarized epithelia. Arp2/3 and its NPF, WAVE/SCAR, are essential for C. elegans embryonic morphogenesis. We show that WAVE/SCAR and Arp2/3 regulate endocytosis and early endosome morphology in diverse tissues of C. elegans. Depletion of WAVE/SCAR or Arp2/3, but not of the NPF Wasp, severely disrupts the distribution of molecules proposed to be internalized via CME, and alters the subcellular enrichment of the early endosome regulator RAB-5. Loss of WAVE/SCAR or of the GEFs that regulate RAB-5 results in similar defects in endocytosis in the intestine and coelomocyte cells. This study in a multicellular organism supports an essential role for branched actin regulators in endocytosis, and identifies WAVE/SCAR as a key NPF that promotes Arp2/3 endocytic function in C. elegans.
AB - Cells can use the force of actin polymerization to drive intracellular transport, but the role of actin in endocytosis is not clear. Studies in single-celled yeast demonstrate the essential role of the branched actin nucleator, Arp2/3, and its activating nucleation promoting factors (NPFs) in the process of invagination from the cell surface through endocytosis. However, some mammalian studies have disputed the need for F-actin and Arp2/3 in Clathrin-Mediated Endocytosis (CME) in multicellular organisms. We investigate the role of Arp2/3 during endocytosis in Caenorhabditis elegans, a multicellular organism with polarized epithelia. Arp2/3 and its NPF, WAVE/SCAR, are essential for C. elegans embryonic morphogenesis. We show that WAVE/SCAR and Arp2/3 regulate endocytosis and early endosome morphology in diverse tissues of C. elegans. Depletion of WAVE/SCAR or Arp2/3, but not of the NPF Wasp, severely disrupts the distribution of molecules proposed to be internalized via CME, and alters the subcellular enrichment of the early endosome regulator RAB-5. Loss of WAVE/SCAR or of the GEFs that regulate RAB-5 results in similar defects in endocytosis in the intestine and coelomocyte cells. This study in a multicellular organism supports an essential role for branched actin regulators in endocytosis, and identifies WAVE/SCAR as a key NPF that promotes Arp2/3 endocytic function in C. elegans.
KW - Actin nucleation
KW - Early endosomes
KW - Endocytosis
KW - Morphogenesis
KW - Nucleation promoting factors
U2 - 10.1016/j.ydbio.2013.03.012
DO - 10.1016/j.ydbio.2013.03.012
JO - Developmental Biology
JF - Developmental Biology
Patel FB, Soto M. WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia. Developmental Biology. 2013 May 15;377(2):319-332. https://doi.org/10.1016/j.ydbio.2013.03.012


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