It's the heartbreak of letting someone down, having never been able to fulfill one of their final wishes. It's the guilt of procrastinating beyond the point of action and living with it. It's the yearning to make amends and also to commemorate. That's how Open Orchard Revival began.
Buehner wanted to give her this gift, regardless, so he asked local musicians—the five members of harmony-laden bluegrass-infused The Folka Dots and three members of Buehner's twangy alt-country band The Trappers—to collaborate on a gospel album as Open Orchard Revival.
"It's the way I can show expression to people—through music," he says. "That's the only thing that I could turn to: to make a record and dedicate it to her." Open Orchard Revival tapped into the old-timey and traditional sounds they know, love and play on What Are They Doing in Heaven Today?
Young was a music lover, but not necessarily a gospel-music lover; she was "David Archuleta's biggest fan," Kiki says. No, really. The pop star even appeared on KSL to wish her a happy 97th birthday months before she died. "You'd walk into her house and there was a huge shrine to him, and there I was: a tiny little photo in the corner," Buehner says with a laugh. Despite that, no Archuleta tune made the cut.
Each of the album's 11 tracks—mainly gospel numbers—were chosen by a band member because the song was near and dear to their heart. For instance, Corinne Gentry (The Folka Dots) chose "People Get Ready" by The Impressions, because it "just carried me through my adolescence—I listened to it a million and nine times." Kiki Buehner picked "What Are They Doing in Heaven Today?" written by Charles Tindley and recorded by Washington Phillips. "It's exactly what the record is about: the essence of being comforted by this idea that there's something else for your loved ones who've passed away," she says. Other album highlights include "I'm Gonna Sing" and "Softly & Tenderly" by Hank Williams.
Gospel music is perfect for a memorial because it's so simple—in arrangements and lyrics—that it cuts to a message's emotional core. It's reassuring to believers of the sweet hereafter, but also provides something for the nonbeliever.
"I'm not religious at all, but these songs give me a lot of comfort. The ideas aren't necessarily something that I believe in, but I love listening to the musicians, because they are so sincere. It makes you feel all warm and fuzzy," says Marie Bradshaw (The Folka Dots).
The recording process came without premeditation. The ensemble—constantly rotating based on who was available any given Sunday morning—would learn a song and record it the same day. In the Buehner's basement—Orchard Studios—the musicians would sit in a circle and record the entire album on analog tape (with a machine once used by Levon Helm for Tres Hombres, Buehner states pridefully).
"I don't know if I can ever go back from tape. It sounds so warm and beautiful," Bradshaw says. "It's way more expensive, but worth it." Open Orchard Revival launched a Kickstarter campaign to crowd-fund $10,000 by Dec. 14 for a vinyl run of the album. As of press time, the campaign was still under way and the goal had not been reached.
What Are They Doing in Heaven Today? is the sort of album that fills you with hope, yet is touching enough to evoke tears. The music stands on its own. And with that, Buehner feels like he has met Grandma Edith's wish.


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redpajama_set_name: RedPajamaGithub


We got another lift from Brixen to Hotel Steineggerhof 43km away. A train to Bolzano and cab will take you to the hotel if you don`t have a car.
We drove from Hotel Steineggerhoff and left a car parked at Nova Levante, and shuttled a bit further up and rode towards Carezza Pass to Moena. During this section things went horribly wrong for Lee. After sending Lee home in a cab we continued down the trail and then on a bike path road ride down to the Latemar Gondola and Chair up to Latemar. We then rode along Wanderweg 22 to Bewallerhof than back to Nova Levante.
Hotel Steineggerhof. Very busy considering it`s location. That`s probably because they have awesome food, a spa and swimming pool and are great people! Kurt Resch started this hotel with his family. Previously it was a big old house until he converted into a hotel and created an excuse for himself to invite people to this area so he can spend his time biking and hiking! Hmmmm. It is also a Bike Hotel Sud Tirol. You can find more information on their bike programs HERE. Check it out for a very affordable guided bike vacation in this unique area.
At the Hotel we met Daniel Schaefer who was to ride with us for the next four days and provided many nice photo poseur shots! And Manfred Stromberg, the Rotwild Rider and rep who was vacationing with his girlfriend Franzisca. Here we ate!
The food at the Bike Hotels is generally a set menu where you do have two options for the main meal. While some may not like to eat from a set menu, I was happy to defer to the locals in their choice of fresh ingredients and menu items. We have yet to be disappointed.
A breed of horse native to Sud Tirol is the Haflinger. Bred for the mountains in the 19th century it is a sturdy horse of a distinct chestnut colour. Its variety now is due to cross breeding.
Trail pics and the Latemar Gondola.
Then Lee crashed… We were on a double track grassy road with slick muddy sections. He zigged when he should have zagged. So much for fall riding!
He took a taxi home, iced his shoulder and ate pastries.
Our group with another group from Hotel Steineggerhof that was out that day.
We took the Gondola and Chair 1100m`s up.
We stopped at Kurt`s mother in law`s house, which is about 400 years old! She generously fed us pasta!
Then we continued on and came to Lago Di Carezza – A stone mermaid sits on the bank of this Lake. She used to be real until she disappeared after a sorcerer tried to capture her by creating a rainbow over the lake to lure her to him. She saw him and disappeared. He then CRUSHED the rainbow into the lake creating it`s vivid colours. REALLY – read about it here!
We then stopped by this bench which was built by the family of a man after he died who like to walk here. They left a little gin stash for him if he comes back!
We continue on the path with the Dolomites ever present.
Then back at the Hotel Steineggerhof for dinner and relaxing!
We didn`t ride on Wednesday due to rain. Good day to rest! Again looking at the map and having the bike guide resources of Kurt Resch you could easily spend a few days riding in this area.
This entry was posted in 2012, bike and tagged hotel steineggerhof, latemar, sud tirol, sud tirol2012, switzerland2012. Bookmark the permalink.


Dr. Loken brings more than two decades of experience in technology and specifically, within high performance computing. For the past 16 years, Dr. Loken has held progressively senior roles at the University of Toronto, most recently as the Chief Technical Officer at SciNet.
Prior to this role, Dr. Loken held visiting academic and research roles at New Mexico State University, University of Missouri and St. Mary's University, Halifax. He obtained his PhD from Queen's University in Physics and Astronomy.


Roghni Roti is a flat bread which is cooked on a flat or slightly concave iron griddle called a tava. This is served hot and brushed with ghee or butter. It can be used to scoop other foods, or served stuffed with a filling. This is a deliciously soft roti.
Mix salt, sugar , yeast and ghee with the flour til it resembles bread crumbs. Add milk and cream and knead to a soft dough. cover and leave it aside for an hour to rise.
Dived the dough in 8 portions, take 1 ppoortion between your plams roll inot a ball, lightly dust the ball with flour, place on a rolling board, roll it out to a disc a of about 6 inches.
Repeat this step with all the portions of dough. Keep aside for minutes.
Heat a griddle, place the roti and cook on one side until light and golden. then flip and cook till golden and crisp.
Remove and brush with ghee. Serve .
I love roti bread and I'm so glad you shared this recipe.
I love that there are so many amazing flatbreads to choose from in India! This roti sounds delicious!
Amazing puff!! Your roti looks so perfect! Can't wait to try this!
Thanks so much for posting this recipe. It is definitely going on my to make list.
I must admit that I have heard of roti before but never knew exactly what form it took and to see yours is such a valuable learning lesson for me. Beautifully done!
Absolutely beautiful! I can only imagine how good it smells.
That looks pretty much like melt-in-your-mouth Roti, Sneha! Perfect!
Wow, perfectly made yeasted rotis. They look great.
It sounds similar to naan but boy it really puffs up!
I am so impressed with your perfectly rolled thin circles of dough, Sneha! They look like you cut them out with a circle cookie cutter, they are that perfect.
So jealous of your perfect roti! I'm going to have to try your recipe and hope I get it half as perfect.
Beautiful roti, Sneha! Those circles couldn't be more perfect.


I have an issue with sparkfun.com I have never encountered before. Some time ago I searched for the term "audio." Ever since, every single page that opens on your site has that word entered in the search box and the page obscured by a long list of suggested results. To read the page I have to click the search box, select the contents, delete. Every single page! It's so annoying it has really dissuaded me from ordering from sparkfun. I have tried deleting your cookies, setting to accept no cookies, clearing cache and history. It's always there. Doesn't matter whether I'm logged in or not. There's no problem with any other site. The issue exists with Firefox (37) and Chrome (42) but not with IE 11. I normally use Firefox and don't want to change browsers just to shop at sparkfun.
What's up with this? Any ideas?
That's a first. Just tried it and it doesn't happen to me using Firefox.. It sounds like a setting. Check your profile settings..
It's a first for me, too. It's not obvious how it's even possible. I didn't see anything in Profile that could be related. (And every time I move from Settings to Profile to Orders to Addresses, etc., I get a long list of suggestions for "audio." Firefox and Chrome afflicted. Internet Explorer not.
Can you take a screenshot of what you're seeing?
Here are three screen shots in a composite.
Top--After entering sparkfun.com in address bar and opening.
Center--After selecting and deleting "audio" from search box.
Mysterious. I'm going to keep looking. It seems odd that it affects only Sparkfun.
Hooray! I found it. I use Lastpass and it was (for some reason) filling the search box as a form fill. It's fixed. It didn't affect IE because it doesn't accept automatic fills. If it had affected more than just one site I might have found it sooner. I'll let Lastpass know about it since it wasn't set to record form contents.
Thanks for your replies. Just keeping me working on it helped a lot.


Dimensions: Dimensions: 168 x 480 x 720 in.
Not a link but reading is still allowed in the digital age (read) City of Dreams: A Guide to Port Townsend, Peter Simpson, Editor. Port Townsend: Bay Press, 1986.
A sculptural interpretation of the old coastal defense bunkers. The work is an integrated plaza, with seating and contemplation areas, which include stone groupings, tree groves, and 7 ten foot high metal monoliths with porcelain enameled plaques containing poems by Sam Hamill (Click here and here and here, to read the poems). The art work references the gun battles and military function of the nearby fort and includes a replica of the Kinzie Battery bench, concrete "chairs" and bunker gutters, and a roofed platform.
On this site stood the barracks which housed members of the Army Corps of Engineers, who from 1898 to 1907, were responsible for the design and construction of the artillery batteries at Fort Worden. The concrete vault in which the plans for the batteries were kept is all that remains of the original structural.
Memory's Vault is a work of art created through the efforts of the artist, individuals and state agencies working collectively to mark in a new way an important place in Washington's history. It is a place for contemplation-of nature, of man and his intentions at Fort Worden.
Washington State Arts Commission in Partnership with Washington State Dept. of Corrections, State Parks and Recreation Commission./Funding was provided through the Art in Public Places Program, Washington State Arts Commission./Built by Fabrication Specialties with assistance from inmates of the Clallam Bay Corrections Center..


Based in New Orleans, Ubuntu Village is a community organization that advances social, economic, and transformational justice for children and communities. In June, Ernest Johnson, co-founder and Director of Ubuntu Village and member of the Equal Voice Action Board and Family Advisor Community, wrote about Ubuntu Village's "Show Your Love" campaign to stand up against hate and divisiveness and "show our neighbors and our communities that we care." Watch the video to see how members of the New Orleans community are showing their love, supporting their neighbors, and building a stronger, more inclusive community.
This video was shared by Equal Voice News.


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Q: Back Button Bug withjQuery hashchange event and animate scrollTop I'm not sure if this is a bug or the way wrote it but any help with be great!!
I am using jQuery hashchange event from Ben Alman which I have used in other projects for
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redpajama_set_name: RedPajamaStackExchange


Hello Fresh vs Blue Apron: Which Meal Delivery Service Is The Best?
It can feel like a full-time job just cooking three meals every day. Given the combination of preparing ingredients, doing the actual cooking, and then cleaning up everything, it takes most folks an hour and a half to do a home-cooked meal. In order to save some time in the kitchen, some busy households wind up resorting to getting takeout, ordering delivery, using pressure cookers and slow cookers, or just signing up for home delivery meal services.
If you choose to do the meal delivery service thing for yourself, then you need to pick a meal prep delivery service that will work with your diet and lifestyle. Given how many meal prep service options are on the market right now, there are quite a few factors that you need to consider, such as price, dietary needs, taste, and delivery schedules. In order to help you learn just what some of the best meal delivery services can do for you, we're doing a comparison of a pair of the most popular dinner delivered choices, and for the purpose of this home delivery meals review article, we are going to compare Blue Apron Meals and Hello Fresh Food Delivery.
Easy recipes that taste great!
Blue Apron vs Hello Fresh: Which one of these healthy food delivery services should you pick?
This direct comparison between the two of them explains the ins and outs of each healthy meals delivered service, including taste, shipping, food quality, diet and food options, and prices, to help you make an informed decision when it comes to choosing the best food delivery service.
Meal Delivery Plan Prices: It ranges from $8.74 up to $10 per serving.
Fresh Food Delivery Dietary Options: They do have a plan for vegetarians. While HelloFresh does have some gluten-free ingredients in some of their individual meal options, they don't have a fully gluten-free plan. On the other hand, they do let consumers know which of their meals are free of nuts, eggs, and gluten. There are also shellfish warnings where applicable. You get to pick your recipes, so this means you can pick out the meals you enjoy the most or just customize your meal selections to whatever dietary needs you currently have.
Food Selection/Variety/Quality: This meal kit company has a whole team of dietitians and chefs that come up with 15 new recipes every week. The meals they come up with are typically healthy and balanced on a nutritional level. Accessing the nutritional information of these meals is easy. While Hello Fresh offers healthy meal options, it should not be treated like a Nutrisystem-type diet plan, as they emphasize good food, not dieting or weight loss.
But we all know that eating healthier can help us with our weight loss goals, as diet is 80% of the battle.
Consumers can customize their Classic Plan by picking a "fit preference" which can incorporate healthier meals in the neighborhood of 650 calories. Consumers can also pick out preferences like quick meals, things free of shellfish, or various options where meals might involve new cooking techniques and ingredients.
On the HelloFresh website, the company claims that they emphasize ingredients which taste and look the best, and they try to use regional suppliers for sourcing most of their ingredients. Not everything is organic, however.
Packaging/Shipping: Like most meal prep companies, Hello Fresh makes the assumption that consumers will already have some things on hand, including salt and pepper, butter, oil, and sugar, so those ingredients aren't included in their pre made meals boxes. The ingredients and foods they do include, as part of their meal prep near me service, are preportioned for every meal individually, with dairy and meat products put inside cooling materials. Every meal also has a recipe card that has very simple steps to follow, as well as an ingredient list and nutritional information.
Hello Fresh doesn't charge for its shipping, and on delivery days, the boxes arrive inside a 12-hour window from 8 in the morning until 8 at night.
Meal Preparation/Taste: We tried a few recipes, which were easy to make and tasted great. They took between 30 and 40 minutes to make, including reading all the instructions and getting the kitchen ready and finding stuff.
Fresh Meals Delivered Prices: Meals range from $8.74 up to $10.
Dietary Options: There is a two-person, all-vegetarian meal delivery plan. This prepared meals delivered to your door service doesn't offer any other kind of specific dietary plans at the time of writing, although consumers can pick out what recipes they want, in an attempt to try and customize their order to fit into their dietary requirements.
Food Selection/Variety/Quality: On the Blue Apron website, Blue Apron claims to source ingredients right from importers, farms, and family-run purveyors. They say that they take pride in working with over a hundred family-operated farms that use regenerative farming practices. Some of their ingredients are organic, yet in most cases not all of them.
Blue Apron has four, five, or six meals you can choose each week, based on your diet meal delivery plan. Consumers get access to allergy and nutritional information ahead of time to make the right choice.
Packaging/Shipping: Meals from Blue Apron show up using insulated thermal packaging liners with refrigerants in order to keep safe temperatures and fresh food. This healthy prepared meals delivered business also assesses its packing on a routine basis, so it can make the necessary adjustments for variables like weather conditions. However, they do recommend that their customers refrigerate all their perishables immediately.
In each diet food delivery box, you'll get ingredients that are pre-measured and also labeled for every meal, as well as a comprehensive recipe guide that has pictures and steps of instructions you can follow easily. You'll even get the nutritional information about every recipe. What day your shipment will arrive is contingent upon the area you live in. Depending on where you're located, your delivery options might vary.
Meal Preparation/Taste: The dishes we tried were considerably tasty and delicious. We did find that some of the ingredients needed some more prep, so that made things take longer than expected.
Blue Apron's reviews from customers are mixed. A number of consumers don't like the packaging or how they have to jump through a hoop or two in order to cancel the plan. On the other hand, there are others that love the food and the customer service. Blue Apron has a "very good" rating from Consumer Reports. For the most part, Blue Apron seems to excel in the area of taste.
Hello Fresh has a trio of plans. The first is the Classic Plan of three or four weekly dishes for either two or four people. The second is the Family Plan of two or three weekly dishes for four people. The third is the Veggie Plan which can work well for two or four people with three weekly recipes.
Blue Apron has a pair of plan options. Their Classic Plan feeds two people two or three meals each week, and their Family Plan works for four people two to four meals each week.
Both meal prep services near me businesses offer subscription services, but you can optionally skip some weeks if you need to. They also both give you a bit of flexibility in terms of which delivery day you prefer. If you need to cancel the account that you have, Hello Fresh lets you do it online. Blue Apron makes you contact their customer support in order to turn off your account, but they do respond rather quickly.
Hello Fresh has a pair of add-ons. The first one is a useful line of kitchenware, including storage solutions, knives, prep tools, and cooking ware. Their second add-on is a monthly subscription plan for wine; for $89, you get a half-dozen bottles of wine each month. You're able to choose between white, red, and mixed. Blue Apron also has similar add-on options, like an attractive variety of wines you can match to every dish. There's also a retail section, where you can find many types of cookware and other various kitchen supplies.
Which Is The Best Prepared Meal Delivery Service For You?
Both of these meal prep delivery services are great options to try, to see how food delivery services can help simplify your already busy schedule. But like all meal delivery companies, they have their own distinct audiences that like them for one reason or another.
Blue Apron seems to work better for consumers that are passionate about cooking and that want to learn and experience new recipes and flavors in their kitchen.
Hello Fresh on the other hand, who we would consider to be the winner of this comparison appeal more to consumers that are looking for very easy to cook recipes with great flavors and who are looking for a family size meal delivery service.
Special Offer $60 Off Blue Apron!
Special Offer $60 Off Hello Fresh!


Kathryn G. -- lovely backing fabric!
Carol F. -- QOV blocks!!!
Connie P. -- little hands!
Connie P. -- Postcard frenzy!
Connie P. -- prayers & stitches!
Connie P. -- sew talented!
Mary A. -- nice pattern and color choice!
Mary A. -- pieced stars and all ... nice work!
a vintage hankie for the first layer.
This gal is an inspiration to all of us ... you rock, Pat!
Sally W. -- "no sew" wall hanging!
Katherine H. -- hmmm I think Connie and Sally are thinking of making one, too!
Rhonda B. -- nice work!


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text:
Guest Commentary: Data visualization--New directions or just familiar routes?
by Edmund Champness of Optibrium	| Email the author
Data visualization tools make it very easy to represent our data graphically and present it in a way that clearly communicates patterns and trends. But, there is a risk that visualizations may be used, in practice, to confirm or justify our own hypotheses and biases. Instead, can data visualizations bring to light patterns in our data, drive new hypotheses and show us things we weren't expecting?
Given the efficiency with which we can process visual information, it is easy to explain the appeal of data visualization. At its best, a visualization can highlight patterns which numerical analyzes might otherwise miss. Anscombe's quartet (Anscombe, 1973) is a good example of four data sets which are statistically very similar, but which when visualized show very different relationships. This sanity check can be invaluable, and yet it should be remembered that inappropriate choices of plot type, axis scales or directions and color can result in visualizations which might be uninformative or misleading at first glance. Our ability to spot visual patterns quickly can work against us when an inappropriate visualization is presented, whether or not the creator was attempting to mislead us deliberately.
If we consider a drug discovery project for which we have measured potency data, a common question to ask might be "On which compounds should I focus my attention?" We will illustrate this using an example set of 264 compounds, representing six different chemical series, for which 5-HT1A activities have been measured. The examples in Figure 1 show the importance of choosing an appropriate way to represent the range of potencies across the chemistries. The simple histogram shown in A gives a good overview but tells us nothing about how the potencies are distributed across the chemical series, until we introduce some color, as in B. This still isn't very clear, given the different number of compounds in each chemical series, whereas using a two-dimensional histogram in C and D the height of each bar shows the average potency of a chemical series. The choice of y-axis scale also influences our view of the data, and in C the chemical series look almost identical, whereas in D there appear to be significant differences—but what is the "right" range? In E, having chosen a range based on a potency level we might consider as "inactive to very active," we can also see the importance of adding error bars to give some indication as to the distribution of potencies. This highlights the value of representing these data using a box plot instead, as in F. Now it becomes clear that each series contains some potent compounds, but the indole-3- alkylamines certainly appear to be the most active.
Of course, potency is just one of the properties we would need to consider in order to identify a high-quality lead compound, and in our data set we also have predicted values for a number of typical absorption, distribution, metabolism and excretion and physicochemical properties. While we could create a box plot for each property of interest, this would require us to look at and, most importantly, make sense of a large number of visualizations. We could attempt to put many dimensions of data into single a scatter plot—three dimensions plotted with others represented by color, size, transparency, etc.—but unless there are some very obvious outliers, it is likely to be very hard to interpret.
It is worth considering, therefore, the kind of information with which we typically make decisions in drug discovery. All of the properties used to analyze and select compounds are derived from models of the ultimate human patient in which we are interested, whether those models are in vivo, in vitro or in silico. All measured data, however accurate, will contain some degree of uncertainty due to experimental variability, while in-silico models will contain some statistical error. As an example, a good root-mean-square error for an aqueous solubility prediction represented as logS(µM) is approximately 0.6. In practice, this means that a logS value of 1 (corresponding to 10µM) represents a fairly soluble compound but which we only know with 95-percent confidence has an actual aqueous solubility somewhere between 630mM and 0.16nM. Knowing that the real value lies towards one end of the range or the other might have a significant impact upon a decision we make about selecting this compound.
And this is just a single property. It is common to base compound selection decisions on criteria for multiple properties. At their simplest, these criteria might just be cutoffs when we believe that an acceptable compound will have a property value on the "right" side of a threshold. When we consider the uncertainty around our data points, even a value on the "right" side of the threshold might have some probability of being unacceptable. In some cases, poor property values with high uncertainties may even represent better opportunities for optimization than very accurate values which fall just short of the necessary criteria.
Adding this information about uncertainty into any data visualization will improve its representation of the true nature of the data, but this comes at the cost of interpretability. Just adding error bars to our plots isn't likely to solve this problem.
One approach to dealing with this is to use multiparameter optimization (MPO) to generate a score that encapsulates multiple properties. There are several approaches to MPO (Segall, 2012), but by using one that explicitly considers the uncertainty, we can significantly reduce the number of dimensions we need to visualize. Applying this to the set of 5-HT1A compounds, a single visualization can now represent all of the underlying data, giving a more comprehensive picture of which chemical series have the greatest potential. In Figure 2, the compounds have been scored and plotted from left to right in order of descending score. We can see error bars which indicate when we can select between compounds with confidence, but the two highlighted series (arylpiperazines and aminotetralines) are represented by green and pink points, which dominate the left-hand side of the plot where the highest scores lie. This is despite these series not including the most potent compounds, as shown in the histograms below the representative compound displayed for each series.
The visualization of any complex data set is problematic, but even much smaller sets can present challenges. If we consider a subset of the 5-HT1A compounds, comprised of the drug Buspirone and a small number of analogs, we might hope to determine relationships between their structures and two important properties, potency and metabolic stability. The goal in this case is to identify structure-activity relationships (SAR) to design a potent, stable compound. Carrying out an R-group analysis and creating an SAR table for each property (Figure 3 A and B), we can quickly see that the combinations of R-groups which result in the highest potency do not give the best stability, and vice-versa (in both cases, the greenest circles represent the best values). On the other hand, if we create an activity neighborhood diagram, Figure 3 C, we can visualize the relationships between the compounds in a different way. Choosing a representative compound with average potency and stability values to be at the centre, the other compounds are organised in a spiral with the most structurally similar closest to the middle. The cards are colored by their metabolic stabilities, with green being the highest. The links show the difference in potency, with green showing the greatest difference and the arrow showing the direction in which the potency increases. Therefore, a green arrow pointing towards a green card, indicating a more potent and stable compound, easily stands out. Using this approach quickly highlights the original problem, that simply moving a single functional group can modify a compound from being "stable and not potent" to "unstable and potent." The compound that stands out, however, which is both potent and stable, but not easily apparent from the SAR table, results from a combination of changes—an important point that may otherwise have been overlooked.
At each decision point, the choice of visualization can be pivotal. The way we perceive our compounds depends upon those around it: Have we explored the surrounding chemical space thoroughly enough to adequately evaluate a series? Do we have data of sufficient quality to confidently distinguish the good compounds from the rest? When it comes to making decisions about compounds, it is often the relationships between compounds that will influence the way we choose the next compound. Any visualizations which simplify or hide these relationships have the potential to bias our perception of the data.
Edmund J. Champness is chief scientific officer of Optibrium Ltd. With a background in Mathematics, he joined GlaxoWellcome in 1995 working as part of a pioneering team building predictive pharmaceutical tools. He developed the first graphical user-interfaces for working with predictive models, which were adopted globally within GlaxoWellcome. He was a core member of the team which established the U.K. operation of Camitro in 2001 and remained with that company through a series of mergers and acquisitions (ArQule, Inpharmatica and BioFocus DPI) until 2008. During this time, he designed and built the StarDrop software and, in 2009, co-founded Optibrium.
Anscombe, F. (1973). Graphs in Statistical Analysis. American Statistician, 27(1), 17- 21.
Segall, M. (2012). Multi-Parameter Optimization: Identifying high quality compounds with a balance of properties. Current Pharmaceutical Design, 18(9), 1292-1310.http://www.optibrium.com/


Team carried out a slew of rescue missions in Brazil following the dam collapse that left dozens dead.
On Friday morning, the IDF aid delegation landed in Israel after completing its mission in the area of the collapsed dam in Brazil. The delegation was welcomed with a ceremony that was held by the Commanding Officer of the Home Front Command, Maj. Gen. Tamir Yadai in the Ben Gurion International Airport.
During the delegation, the troops carried out a number of missions to rescue missing people, following the Brazilian emergency authorities' request. The delegation assisted in locating and rescuing dozens of missing people using a range of advanced technological means. In addition, the soldiers assisted the local Brazilian emergency authorities and shared innovative techniques who will assist and serve the authorities in the searches.
The IDF aid delegation included approximately 130 officers and soldiers in mandatory and reserve duty and was accompanied by the IDF's Military Attaché in Brazil, Col. Raed Kadur, the Israeli Ambassador to Brazil, Mr. Yosi Sheli and his staff.
Before the Israeli delegation departed, the Brazilian rescue authorities held an appreciation ceremony for the IDF delegation.


Paper embroidery is a delightful way to add embellishment and texture to any paper craft.
Learn a new way to embellish your paper projects! If you've never tried sewing paper, you must learn how. With this Embroidery on Paper tutorial, you will learn How to Paper Stitch on cardstock. This tutorial demonstrates the back stitch, and it offers a variety of tips and techniques for stitching effectively on paper.
Choose any design of your choosing and use this tutorial for any project moving forward! A stitched design on a handmade card adds so much character to your projects and it really creates the handmade feel. For a homey touch on your next paper craft, consult this paper embroidery tutorial.
After the tutorial, you will find several supplemental materials to help you perfect sewing paper. If you like to follow along through watching someone work, then you will love our video tutorial. To pin or save a quick reminder of how to sew paper, check out the infographic. Finally, we are featuring some amazing paper stitch projects with which you can test your skills with.
Measure out your card and cut it to size.
Draw your design on the front of the card (or on a separate piece of cardstock to be mounted on the card base). You may draw the design freehand like this example, or you can trace your design using a template.
Pierce your paper along the design. Use your paper piercer or a thumbtack if you do not have a paper piercer on hand. You want to pierce your paper first because, this way, it is easier to gauge the distance between each hole, and you will not dull your sewing needles on the paper.
That said, you want to keep the distance between each pierced hole as consistent as possible because once we stitch, it is easy to see any irregularities. The distance between holes in this example is about a centimeter.
Erase your design before you begin stitching.
Thread your needle and pull it through the second hole from the edge of the design. You will insert the needle from the back of the card and pull it through the front. Pull the thread almost entirely through the hole and secure the back with tape. It is not necessary to knot the ends of the thread because we are taping it down to secure it.
Begin back stitching the design on the card. Back stitching creates a wonderful look because, unlike your typical running stitch, there will be no spaces left between the holes in your design. Working left to right, you will first pull the needle from the back of your card through the second hole in the front of the card.
Repeat this pattern, and continue to the end of your design, snip the ends, and secure the design with another piece of tape.
From card making ideas and DIY art to educational and fun crafts for kids, these paper stitch projects are enjoyable for anyone in the family.
This is an amazing idea. I used to cross stitch a long time ago and I still have a lot of embroidery floss. I make a lot of paper crafts, both greeting cards and home deocr. I like the idea of stiching on paper and giving texture to my paper crafts. I am trying to think of a simple Christmas design I can make to try this craft before the holidays get away from me!
I have never heard or seen paper sewing before. Oh my gosh I Love It. I sew on fabric all the time but never thought to do this on paper. This sewing on paper project can make some cute cards for any occasion or for scrapbook pages. I think I will use some card stock as my paper when I make these designs. Great tutorial. A new craft for me. Anyone make cards like this?


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150 NY Airport Workers to March to LaGuardia in Solidarity with Philly Airport Strike
Today more than 500 airport workers at Philadelphia International Airport have gone on strike to protest PrimeFlight's low wages and unfair labor practices. The action is expected to be the largest strike in the three-year history of SEIU's airport workers campaign. It comes just days before the same workers set to join fast food, home care and other workers in a day of action on April 15.
In New York, and across the country, PrimeFlight employees will stand in solidarity with their striking brothers and sisters in Philadelphia. In New York, PrimeFlight employees will march into LaGuardia airport to send a delegation to their employer PrimeFlight and the airlines it services— U.S. Airways and American Airlines. They will deliver a solidarity message to these companies in order to bring attention the health and safety and wage and hour abuses that airport workers in New York and New Jersey have endured while working for PrimeFlight.
When: Thursday April 2, 2015. 11:30 a.m.
Who: PrimeFlight wheelchair attendants, baggage handlers, customer service agents, sky caps and cabin cleaners who work at LaGuardia and Newark Airports.
Where: LaGuardia Airport, Terminal B arrivals. Meet up in parking lot 1.
Why: PrimeFlight is a Nashville-based company that contracts with airlines to provide ground handling, aircraft cleaning and terminal/passenger services to airlines at 44 airports nationwide. While PrimeFlight is the beneficiary of various public subsidies, the company pays its workers poverty wages and does not provide affordable benefits, forcing many to rely on public assistance to survive. In New York PrimeFlight employees have also filed various lawsuits and complaints against their employer for health and safety violations and wage theft. The Occupational Safety and Health Administration has cited PrimeFlight for five Health & Safety violations at Newark Airport. PrimeFlight wheelchair attendants, baggage handlers, customer service agents, sky caps and cabin cleaners have been fighting alongside 12,000 other subcontracted airport workers in New York and New Jersey for higher wages, benefits and the right to union representation. They are part of a growing mass movement of airport workers who have been organizing in cities around the country who are standing in solidarity with Philly airport workers today. They say, "Enough is enough. PrimeFlight, make airport jobs good jobs!"
Visuals: Airport workers marching through LaGuardia Airport to deliver a violation ticket to their employer.
With 145,000 members in eleven states and Washington, D.C., 32BJ SEIU is the largest property service workers union in the country.


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Q: RSS Feed disappears on Postback in ASP.NET I have an asp.net page which shows an RSS feed generated using feed2js.org site. It provides javascript code to be put on the webpage inside the tags where you want to show the feed. For example I wanted the feed to show in table so I put the javascript inside the  tags:

script language=\"JavaScript\" src=\"http://feed2js.org//feed2js.php?src=http%3A%2F%2Fwww.medicalnewstoday.com%2Frss%2Fpharmacy.xml&num=1&targ=y&utf=y\" charset=\"UTF-8\" type=\"text/javascript\"></script>

The page works fine when it first loads and shows the feed but when I click a button on the page the feed disappears. Can someone please help me out with this issue?

A: You should remove all those unnecessary backslash, if by some chance you inject the script tag with a javascript function, you need to make sure it render the script tag correctly


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Annularodes is a genus of land snails with an operculum, terrestrial gastropod mollusks in the family Pomatiidae.

Species
Species within the genus Annularodes include:
Annularodes boqueronensis (Torre & Bartsch, 1941)
Annularodes canoaensis (Torre & Bartsch, 1941)
Annularodes cantarillensis (Torre & Bartsch, 1941)
Annularodes indivisa (Welch, 1929)
Annularodes inquisita (Pfeiffer, 1929)
Annularodes morenoi (Torre & Bartsch, 1941)
Annularodes obsoleta (Torre & Bartsch, 1941)
Annularodes perezi (Torre & Bartsch, 1941)
Annularodes pilsbryi (Welch, 1929)
Annularodes terneroensis (Torre & Bartsch, 1941)
Annularodes unicinata (Arango, 1884)

References

Pomatiidae

redpajama_set_name: RedPajamaWikipedia


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Home » Administration & Business Services » Operational Support Services » Emergency Preparedness » Parent Emergency Information » Frequently Asked Questions (FAQ)
What is emergency preparedness?
RCOE has taken steps to ensure your child's safety while in school. Each school has developed a crisis response plan. Emergency preparedness is basically preparing the steps you will take in the event of an emergency, such as contact information, communications, and evacuation plans.
Where do I look for information and to stay informed?
The Riverside County Office of Education has a number of different ways to get the message to parents. General information is placed on our website which is updated immediately in the event of an emergency, or school cancellations. Additionally, Riverside County Office of Education works in partnership with the Riverside County Office of Emergency Services to outreach with local television and radio stations that assist in getting emergency information to the public.
Parents are encouraged to listen to the radio, watch television or go to the RCOE Website Emergency Preparedness Page for the latest messages from Riverside County Office of Education. Parents should not call their child's school. The individual schools need to keep their lines open for communication with emergency responders.
What is Professional Crisis Intervention?
Crisis response teams provide care and support for students and staff affected by a crisis or an emergency. School psychologists, school nurses, and counselors staff these teams.
What is "heightened security"?
Parents may hear the term "heightened security" as federal code levels change from yellow to orange to possibly red. Each school has developed a crisis preparedness plan that outlines the steps to take in the event of emergency. Plans include contact information, communications and evacuation plans. While the school system has security plans in effect every day at all schools, different situations call for heightened security levels. These include additional security checks, more stringent guidelines for where and when field trips and activities may occur, and additional supervision during class changes, especially for students moving to and from mobile classrooms.
How will my child's school handle an emergency situation?
All Riverside County Office of Education's facilities have an emergency preparedness plan. The specifics of each plan differ for each location. The response to each situation will differ based on the specifics of that situation. The flexibility of the plan is key to the success of the response. In general, each plan involves the designation of a crisis management team; development of 1) lockdown, 2) shelter-in-place, and 3) evacuation procedures; preparation of a portable critical response kit that contains key information and supplies; designation of one or more appropriate evacuation sites; provisions for training personnel and updating the plan; checklists for dealing with specific types of incidents; and resources for help before, during and after an event. All RCOE school plans have been reviewed within the last twelve months, and school crisis teams have received training.
What is a School Emergency Plan?
School emergency plans vary from school to school based on their location and facility. Responses also vary depending on the situation, and plans are flexible to allow schools to respond based on the emergency. There are general components of each plan, which make up the essence of the crisis management teams' responses. All plans identify a crisis management team composed of school and administration building staff, who have been trained in handling emergencies. There are procedures for evacuation, shelter-in-place, lock-down and heightened security. Every school and school system center has information about designated evacuations sites, checklists for dealing with certain types of incidents and resources for before, during and after an event. All school plans are reviewed at the beginning of each school year. We do not release specific plans for security reasons, but if parents have a concern, they can call their child's principal.
What is a Shelter-In-Place?
Shelter-in-place is a temporary solution to a short-term problem. It is not the school system's intention to detain children any longer than necessary. However, the public health or safety officials may direct the schools to shelter students. Shelter-in-place is an effort to isolate students and staff from danger. Staff is responsible for accounting for students. In the event of a chemical emergency, for example, we would bring all students and staff inside the main building and close and secure all windows and doors. All heating, ventilation and air conditioning systems would be turned off. Crisis teams and schools have plans and the materials available to bring children to interior spaces, lock and seal doors to the exterior and monitor radio, television and e-mail for instructions. Buildings will be secured so that no unauthorized persons leave or enter. Parents are permitted to access the building and their children once the school system is notified by safety and health personnel that it is safe to do so.
What is a lockdown?
An emergency may prevent the safe evacuation of a school building and require steps to isolate students and faculty from danger by instituting a school lockdown. In an interior lockdown situation, all students are kept in classrooms or other designated locations that are away from the danger. Faculty members are responsible for accounting for students and ensuring that no one leaves the safe area. School personnel will also secure building entrances, ensuring that no unauthorized individuals leave or enter the building. Exterior lockdown procedures may also be used to ensure the safety of students when an incident occurs in the community. Parents are permitted access to the building and to their children if and when it is safe for them to do so.
What about my child's medications?
Parents should make sure that schools have at least two days' worth of medications needed. Parents of students with medical needs that are not known to the school, such as daily medicine or other medical conditions that are administered or treated outside school hours, should contact the school nurse, who can provide additional information and help. All medical information is kept confidential.
What are school emergency cards?
These cards are used to contact parents in an emergency. Parents should make sure that information on emergency cards is correct. If home or office phone numbers have changed since the beginning of the school year, parents should notify the school. Additionally, only people listed on the emergency card are allowed to pick up children from school.
How will I pick up my child in a time of emergency?
RCOE's primary responsibility is to keep children safe and secure. RCOE does not intend to keep children from their parents if a crisis occurs during school hours or school activities. It is the school system's intent to make sure that children are safe inside their schools until such a time that the threat has been reduced. Parents will be able to reunite with their children by following signage at the school or will be informed of a parent-student reunification center location via the school system emergency messaging system and local media – if it is not the school site.
Can I pick up my child?
Parents are allowed to pick up their children unless public safety officials have declared a Lock-down or shelter-in-place response, or if there is some other reason why access to the facility is restricted. During any emergency, school personnel will maintain as safe and normal environment for children within the school as is possible. School is not automatically canceled in emergency situations. Remember, school may be the safest place for children to be.
Who can pick up my child?
Children will not be released to individuals who are not authorized on the student's information card or who do not have written parent authorization. The information card is completed by parents and guardians at the start of each school year. Parents and guardians are encouraged to update the Student Information Card, as needed throughout the school year. Schools will also ask for identification when the child is released.
What if my child is riding a school bus at the time of a crisis?
School bus drivers will be in radio contact with the Office of Transportation for instructions in the event that a crisis occurs while students are in transport. Bus drivers will be informed to use common sense and not travel toward the crisis location. Parents will be informed of the parent-student reunification center location via the school system emergency messaging system and local media.
What is an evacuation parent reunification site?
If public safety officials require that a school building be evacuated, students and staff members will be safely transported by bus to a designated parent-student reunification center. Parents will be informed of the reunification location via the County's emergency messaging system and by local media. At the reunification center, students will be released to their parents upon presentation of proper identification.
Are students allowed to have cell phones at school?
Students are allowed to have cell phones at school. Students are not allowed to have them turned on during the school day. In the event of an emergency, students will be allowed to use their phones to communicate with parents when specified by the principal. It is important to recognize that during an emergency situation, cell phone circuits may become overloaded, interfering with Public Safety officials' ability to communicate. Student's use of cell phones during an emergency will be appropriately limited.
Can I contact my child?
Parents are asked not to call the school in emergency situations so phone lines can remain accessible for handling the specific situation. Parents will be kept informed via the RCOE "All Hazard" Alert Notification system and through the RCOE website Alert and Advisory Page.
In the event of an intruder, terrorist attack, an act of war or other emergency situation, will RCOE School Sites go into lockdown?
The specific actions taken by RCOE in any emergency situation-both County-wide and at individual schools-will depend on the specifics of the situation. Any action taken would depend on several factors, including the level of threat and the advice of local, state, and federal agencies. The safety of students and staff members will be the primary concern in any decision.
Are school sites stockpiling food and water and other emergency supplies?
RCOE is taking action to make sure that schools and offices have the appropriate resources available including food and water and medical for a short-term event. In the event of a large-scale catastrophic event, RCOE would rely on federal and state authorities for assistance.
How parents can help?
Parents are also encouraged to prepare a family disaster plan and practice it so that everyone will remember what to do if a disaster does occur. Everyone in the household, including children, should play a part in the family's response and recovery efforts. Teach your children how to recognize danger signals. Make sure your children know what smoke detectors, fire alarms, and local community warning systems (horns, sirens) sound like.
DO . . .
Make sure emergency card information is correct.
Let children know that if a crisis occurs while they are in school, their teacher will provide them with appropriate instructions.
Tune in to the radio or television. Communication through the media, the school system information line and the web site will let parents know the place and time that they can be reunited with their children.
Keep alert to activity around the schools and on school grounds. Report any suspicious activities.
Keep the school nurse informed of a child's medical condition and provide emergency medical supplies and medication.
DON'T . . .
Rush to the school or call the individual schools in emergency situations. Parents will be kept informed through our website, television and radio stations.
Send neighbors or other individuals not on the emergency card to pick up your children.
The contents of this website were developed under a grant from the Department of Education. However, those contents do not necessarily represent the policy of the Department of Education and you should not assume endorsement by the Federal Government.


Many of our members stay with us for several years and we are very proud to say that many of these have continued in Music. Listed are just some of our past members.
Dominic Wolfendale started playing with EYS as a senior member joining what was then "Obigato" which has since become "Obligato String Quartet" He has also worked with us as a chamber coach and theory teacher. Dominic teaches violin in several schools in Devon.
Flora Farquharson joined Exeter Young Strings aged 4 as one of our very first Mini Music Makers. She then went on to play the viola at the age of 5 and played in one of our chamber groups for many years. Her third and main viola teacher was Rebecca Willson, also a past member and a very active musician and teacher in Exeter. Until recently Flora still played with Obligato String Quartet which had its roots as one of our senior chamber groups but very quickly evolved to become a professional group of musicians performing at various functions and giving performances at venues such as the Bike Shed Theatre.
Flora spent a gap year in India where she is teaching music at an International School. She is now studying the viola at The Royal Welsh School of Music and Drama.
Hannah started cello lessons with Kirsty Hugill aged 8 and soon joined the very first Exeter Young Strings chamber group "Mozart Music Makers".
Hannah continued to play with Exeter Young Strings for many years and moved up to play with "Obligato" which started life as our top Senior Group and went on to become a professional group of players performing at functions and in venues such as the Bike Shed Theatre. Hannah still performs regularly with past EYS members and has given solo recitals.
Rebecca Willson – Joined us age 14 as a chamber group violinist. Rebecca continued playing with us until she left to do her music degree at Dartington. During her degree she started teaching violin and viola and coaching one of our chamber groups. She continued as a member of our teaching team before going on to do a performance MA and to study Kodaly teaching methods. Rebecca still has strong links with Exeter Young Strings coaching young musicians who are unable to attend our Wednesday groups as well as teaching in various schools and running her own Kodaly musicianship courses. She also set up and directs Blue Sky Music which gives summer courses and short workshops.


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Q: Haskell read type inferences Haskell newbie wants to know why the first 3 were ok but the 4th statement blew up:
Prelude> read "5.3" + 5.0                   -- ok
10.3

Prelude> read "5"   + 5                     -- ok
10

Prelude> read "5"   + 5.3                   -- ok
10.3

Prelude> read "5.3" + 5                     -- huh ???
*** Exception: Prelude.read: no parse

I see that :t 5.3 is Fractional whereas 5 is just Num, but both must be returnable from read because the first three commands worked, and (+) should work on any pair of Nums.  What's going on here ?

A: When the type of a numeric expression is ambiguous, Haskell tries to resolve it first to Integer, and then to Double (a floating-point number) if that doesn't work. This is because it would be pretty annoying to have to explicitly specify the types for simple arithmetic expressions.
This specific example happened because 5.3 can't be an Integer (since Integer is not Fractional), so it resolved to Double in that case. But since 5 can be an Integer, and read "5.3" can be any type that can be read, it defaulted to Integer, and blew up at runtime, since 5.3 isn't a valid Integer literal.
If you turn on -Wall, you'll be able to see this type defaulting happen; it'll show a warning when it does. (This is typically quite annoying in practice, though, since such defaulting is very common in GHCi.)


Home » hair growth » hair transplant » hairstyles » hairstyles for fine hair » hairstyles for women » natural hair styles » short haircuts » short hairstyles » wigs » Is Dry Shampoo for Hair A Good Solution?
Is Dry Shampoo for Hair A Good Solution?
If you hate washing your hair and try to avoid doing it as much as possible, you may be curious about dry shampoo for hair. The thought of throwing some powder onto your head and brushing it through is certainly a lot more appealing than getting in the shower, washing, blow drying, and styling and definitely quicker. You know you can save time and money using a product like this so you figure there must be a catch in there somewhere. What are the pros and cons of using powder shampoo?
The good thing about this product is that it is easy and indeed saves quite a bit of time. Many women spend upwards of an hour on the process of washing and styling, particularly those with very curly hair who straighten or use a diffuser. This also exposes your hair to damage from heat so doing it less often helps your hair to be healthier. Moreover, you can save some money on your water and electric bills every time you skip this whole routine.
Another argument in favor of using these products is that they are convenient. In particular, if you stay over at your boyfriend's house a lot, you can just leave a bottle of hair powder at his house instead of lugging around your dryer, straightener and brushes or buying doubles. It's also a great thing to bring on short trips so you don't waste precious vacation time in the bathroom.
The main problem with these products is that they can be a bit tricky to apply. You need some patience at first until you get the hang of applying it, and this is a process you'll probably have to repeat if you ever switch brands because the formulas can be very different. A lot of people say that waterless shampoo makes their hair look too powdery. It's very possible that they are applying too much. You need to start out with just a little and then you can add more if your hair still looks greasy. A little goes a lot further than you'd think so be careful when you're starting out. For some people, the complaint is valid because some formulas really do look more powdery than others.
Another problem is the packaging. A lot of hair powders come in spray bottles in the hopes of easing application. However, many of these sprayers present their own set of problems as nozzles can get clogged and pressurized cans can lose their pep. Some people find that sprays aren't worth it so if you've had bad luck in the past, try a formula that comes in a shaker can instead. This should eliminate most of the problems people have when they say they only get a few uses out of each bottle.


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Q: Is it possible for heat to flow from body having less heat energy to a body having more heat energy? Is it possible for heat to flow from a body having less heat energy to a body having more heat energy?

A: tl;dr: Yes. Specific heat and temperature are different measurements.
The specific heat of a material is a function of temperature that describes how much heat it takes to change the temperature of a material by a specific amount $\frac{dU}{dT}$. Statistical mechanics concerns itself with questions like this. If we integrate the specific heat function from $0K$ to the temperature in question, we find a measure of an object's 'heat energy'.
Temperature, on the other hand, describes the tendency for an object to give up energy. In differential form, $\frac{dU}{dS}$, it's the change in internal energy with respect to entropy. A warmer object with less heat (tungsten, for example) may absolutely be more likely to give up heat than colder object with more heat (water, for example).
As far as the heat pump explanations, I'd encourage you to pull the refrigerator off the wall and touch the radiation coils on the back - they are in fact warm.

A: This is "possible" in a way and it's how technologies like refrigerators and A/C units work.
While there never really is heat energy going specifically from something cold to something hot, the net effect that these technologies employ is moving heat energy from a cooler area to a warmer area. Usually through compressing and re-expanding gasses, the heat is transferred from the cool area to the gas as it is re-expanded and then from the gas to the warm area as it is compressed again.
Strictly speaking, systems always try to reach thermal equilibrium, so heat will never flow from cold to warm in a macroscopic system. The only reason compressed gasses works is that expanding them makes them colder than the cool area (so heat flows in) and compressing them makes them hotter than the warm area (so heat flows out).

A: A body does not have heat energy. Heat energy (or just heat) is the flow of energy between two bodies.
You are probably thinking about temperature, and to answer the question, heat cannot flow from a body with lower temperature to a body with higher temperature spontaneously.
If by "heat energy" you mean internal energy, then the answer is yes, if the body with lower internal energy has higher temperature.
EDIT: After reading your comment, here's very concisely how a fridge works:
The substance you wish to cool is compressed, hence its temperature increases. Heat flows out of the substance to (now cooler) surroundings. Then the substance is expanded to original volume and its temperature decreased in the process.


text:
Mimicry in
Ranitomeya imitator
Rediscovery of Dendrobates captivus
Rare Species for Sale! The Smuggling Crisis
Twomey, E., Vestergaard, J. S., Venegas, P. J., & Summers, K. (2016). Mimetic Divergence and the Speciation Continuum in the Mimic Poison Frog Ranitomeya imitator. The American Naturalist, 187(2), 205–224.
Twomey, E., Mayer, M., & Summers, K. (2015). Intraspecific Call Variation in the Mimic Poison Frog Ranitomeya imitator. Herpetologica, 71(4), 252–259.
Vestergaard, J. S., Twomey, E., Larsen, R., Summers, K., & Nielsen, R. (2015). Number of genes controlling a quantitative trait in a hybrid zone of the aposematic frog Ranitomeya imitator. Proceedings of the Royal Society B: Biological Sciences, 282, 1–10.
Mayer, M., Schulte, L. M., Twomey, E., & Lötters, S. (2014). Do male poison frogs respond to modified calls of a Müllerian mimic? Animal Behaviour, 89, 45–51.
Twomey, E., Vestergaard, J. S., & Summers, K. (2014). Reproductive isolation related to mimetic divergence in the poison frog Ranitomeya imitator. Nature Communications, 5(4749), 1–8.
Brown, J. L. (2013a). Neotropical poison frogs: evolution's guide to parenting, fashion and communication in a dynamic world. Evolutionary Ecology, 27(4), 655–659.
Brown, J. L. (2013b). The evolution of parental care, aposematism and color diversity in Neotropical poison frogs. Evolutionary Ecology, 27(4), 825–829.
Gehara, M., Summers, K., & Brown, J. L. (2013). Population expansion, isolation and selection: novel insights on the evolution of color diversity in the strawberry poison frog. Evolutionary Ecology, 27(4), 797–824.
Twomey, E., Yeager, J., Brown, J. L., Morales, V., Cummings, M., & Summers, K. (2013). Phenotypic and genetic divergence among poison frog populations in a mimetic radiation. PloS One, 8(2), e55443.
Yeager, J., Brown, J. L., Morales, V., Cummings, M., & Summers, K. (2012). Testing for selection on color and pattern in a mimetic radiation. Current Zoology, 58(4), 667–675.
Brown, J.L., E. Twomey, A. Amezquita, M. Barbosa de Souza, J.P. Caldwell, S. Lötters, R. von May, P.R. Melo Sampaio, D. Mejia-Vargas, P. Perez-Peña, M. Pepper, E.H. Poelman, M. Sanchez-Rodriguez, & K. Summers. 2011. A taxonomic revision of the Neotropical poison frog genus Ranitomeya (Amphibia: Dendrobatidae). Zootaxa, 3083: 1-120.
Brown, J.L., V. Morales, and K. Summers. 2010. A key ecological trait drove the evolution of biparental care and monogamy in an amphibian. The American Naturalist 175: 436-446.
Brown, J.L., M.E. Maan, M.E. Cummings, and K. Summers. 2010. Evidence for selection on coloration in a Panamanian poison frog: a coalescent-based approach. Journal of Biogeography 37: 891-901.
Perez-Peña, P.E., G. Chavez, E. Twomey, and J.L. Brown. 2010. Two new species of Ranitomeya (Anura: Dendrobatidae) from eastern Amazonian Peru. Zootaxa 2439: 1-23. | PDF
Twomey, E., and J.L. Brown. 2009. Another new species of Ranitomeya (Anura: Dendrobatidae) from Amazonian Colombia. Zootaxa 2302: 48-60. | PDF
Brown, J.L., and E. Twomey. 2009. Complicated histories: three new species of poison frogs of the genus Ameerega (Anura: Dendrobatidae) from north-central Peru. Zootaxa 2049: 1-38. |PDF
Brown, J.L., V. Morales, and K. Summers. 2009. An experimental demonstration of tactical parasitism of conspecific reproduction via larval cannibalism in Peruvian poison frogs. Biology Letters 5: 148-151. | PDF
Brown, J.L., V. Morales, and K. Summers. 2009. Home range size and location in relation to reproductive resources in poison frogs: a Monte Carlo approach using GIS data. Animal Behaviour77: 547-554. | PDF
Brown, J.L., V. Morales, and K. Summers. 2008. The evolution of parental care, habitat selection and larval life history in Peruvian poison frogs. Journal of Evolutionary Biology 21: 1534-1543. | PDF
Brown, J.L., E. Twomey, M. Pepper, and M. Sanchez Rodriguez. 2008. A revision of the Ranitomeya fantastica species complex and two new species of poison frogs (Anura: Dendrobatidae) from the Rio Huallaga drainage in central Peru. Zootaxa 1832: 1-24. | PDF
Brown, J.L., E. Twomey, V. Morales, and K. Summers. 2008. Phytotelm size in relation to parental care and mating strategies in two species of Peruvian poison frogs. Behaviour 145: 1139-1165. | PDF
Twomey, E., V. Morales, and K. Summers. 2008. Evaluating condition-specific and asymmetric competition in a species distribution context. Oikos 117: 1175-1184. | PDF
Twomey, E., and J.L. Brown. 2008. Spotted poison frogs: rediscovery of a lost species and a new genus. Herpetologica 64: 121-137. | PDF
Twomey, E., and J.L. Brown. 2008. A partial revision of the Ameerega hahneli complex (Anura: Dendrobatidae) and a new cryptic species from the east-Andean versant of central Peru.Zootaxa 1757: 49-65. | PDF
Twomey, E., V. Morales, and K. Summers. 2008. Effects of kinship on intraspecific competition in larvae of the poison frog Ameerega bassleri (Anura: Dendrobatidae). Phyllomedusa 7: 121-126. | PDF
von May, R., Catenazzi, A., Angulo, A., Brown, J.L., Carrillo, J., Chávez, G., Córdova, J.H., Curo, A., Delgado, A., Enciso, M.A., Gutiérrez, R., Lehr, E., Martínez, J.L., Medina-Müller, M., Miranda, A., Neira, D.R., Ochoa, J.A., Quiroz, A.J., Rodríguez, D.A., Rodríguez, L.O., Salas, A.W., Seimon, T., Seimon, A., Siu-Ting, K., Suárez, J., Torres, J., and Twomey, E. 2008. Current state of conservation knowledge of threatened amphibian species in Peru. Tropical Conservation Science 1: 376-396. | PDF
Roberts, J.L., Brown, J.L., Schulte, R., Arizabal, W, and Summers, K. 2007. Rapid diversification of coloration among populations of a poison frog isolated on sky peninsulas in the central cordilleras of Peru. Journal of Biogeography 34: 417-426. | PDF
Roberts, J.L., J. L. Brown, R. von May, W. Arizabal, A. Presar, R. Symula, R. Schulte, and K. Summers. 2006. Phylogenetic relationships among poison frogs of the genus Dendrobates(Dendrobatidae): A molecular perspective and increased taxon sampling. The Herpetological Journal 16: 377-385. | PDF
Roberts, J.L., Brown, J.L., Arizabal, W., von May, R.,, Schulte, R., & Summers, K. 2006. Genetic divergence and speciation in lowland and montane Peruvian poison frogs. Molecular Phylogenetics and Evolution 41: 149-164. | PDF
Brown, J.L., Schulte, R. & Summers, K. 2006. A new species of Dendrobates (Anura: Dendrobatidae) from the Amazonian lowlands in Peru. Zootaxa 1152: 45-58. | PDF
Brown JL, Twomey E (in press). Ranitomeya imitator, R. fantastica, Ameerega bassleri. Species accounts in the book: Andean Poison Frogs. Conservation International.
Brown JL, Siu Ting K (in press). Ranitomeya uakarii and Ameerega cainrachi. Species accounts in the book: Andean Poison Frogs. Conservation International.
Twomey E, Brown JL, Yeager J (in press). Excidobates captivus. Species account in the book: Andean Poison Frogs. Conservation International.
Dendrobates.org
©2018 Evan Twomey & Jason Brown
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text:
Diastolic dysfunction is associated with poor survival in patients with cirrhosis with transjugular intrahepatic portosystemic shunt
Massimo Cazzaniga1,
Francesco Salerno1,
Giovanni Pagnozzi2,
Elena Dionigi1,
Stefania Visentin1,
Ilaria Cirello1,
Daniele Meregaglia3,
Antonio Nicolini3
1Department of Internal Medicine, IRCCS Policlinico San Donato, Università degli Studi, San Donato Milanese, Milano, Italy
2Emergency Department, Ospedale Maggiore Policlinico, Mangialli e Regina Elena, Fondazione IRCCS, Milano, Italy
3Unit of Vascular Radiology, Ospedale Maggiore Policlinico, Mangialli e Regina Elena, Fondazione IRCCS, Milano, Italy
Correspondence to:
Professor F Salerno
Department of Internal Medicine, Policlinico San Donato, University of Milan, Via Morandi 30, 20097 San Donato Milanese, Milano, Italy; francesco.salerno{at}unimi.it
Background: Transjugular intrahepatic portosystemic shunt (TIPS) is a treatment for portal hypertension-related complications. Accurate prediction of the outcome of patients treated with TIPS is important, because some patients have very short survival. Diastolic dysfunction is frequently observed in patients with cirrhosis.
Aim: To investigate whether or not diastolic dysfunction can predict the outcome after TIPS.
Methods: Echocardiography with Doppler exploration was performed before and 28 days after TIPS insertion in 32 patients with cirrhosis. Several echocardiographic measures, including the early maximal ventricular filling velocity/late filling velocity (E/A) ratio as indicative of diastolic function, as well as laboratory, clinical and demographic variables were evaluated as predictors of survival.
Results: Univariate analysis revealed that the presence of diastolic dysfunction observed 28 days after TIPS (E/A ratio ⩽1) and baseline model of end-stage liver disease score were related to survival. Multivariate analysis identified diastolic dysfunction as an independent predictor of death (RR 8.9, 95% CI 1.9 to 41.5, p = 0.005). During the first year of follow–up, six out of 10 patients with an E/A ratio ⩽1 died, whereas all 22 patients with E/A ratio >1 survived.
Conclusions: Diastolic dysfunction estimated using E/A ratio is a promising predictor of death in patients with cirrhosis who are treated with TIPS.
A, atrial maximal filling velocity
ANP, atrial natriuretic peptide
CO, cardiac output
DT, deceleration time
E, early maximal ventricular filling velocity
LVEDV, left ventricular end diastolic volume
LVESV, left ventricular end systolic volume
MAP, mean arterial pressure
MELD, model of end-stage liver disease
PRA, plasma renin activity
SV, stroke volume
SVR, systemic vascular resistance
TIPS, transjugular intrahepatic portosystemic shunt
http://dx.doi.org/10.1136/gut.2006.102467
Published First Online 27 November 2006
Competing interests: None.
Copyright 2007 by Gut
Cardiovascular determinants of survival in cirrhosis
Samuel S Lee Hongqun Liu
Gut 2007; 56 746-748 Published Online First: 22 May 2007. doi: 10.1136/gut.2006.112169


IBM i provides a highly integrated environment, of many application types on a single platform, with very good ease-of-use characteristics from a sysadmin standpoint. Running on Power Systems, IBM i applications can take advantage of high performance, large capacity, high reliability, and leadership virtualization capabilities. As the growth of Linux is obvious to all in the IT industry, some IBM i shops are asking, "Should Linux be investigated and why," since all is good in IBM i land.
I believe that there are several reasons why IBM i users should look at Linux and see what it might offer them. But first, we must recognize that Linux is an operating system, and running an operating system has no real value…. what you need to do as a business is run IT to solve business challenges at the lowest costs. So, let's look at a couple of considerations as to why Linux might be used in conjunction with the IBM i environment.
Most of the new or enhanced applications and solutions are coming from the OpenSource community. This implies that Linux is the required operating system. Additionally, commercial ISVs are seeing Linux as the future platform to build on, due to its broad acceptance and cross platform support. A couple of examples are the new database structures for no-SQL and document databases (i.e., Redis Labs, Mongo, Casandra, Hadoop, etc.) and SAP HANA. In the application arena, there are solutions like Sugar CRM and Magento, to name only a couple.
Linux can run on the same Power System that is running the IBM i environment. You do not have to purchase a new system, and as Linux can run in a partition, as well as integrate and augment the IBM i applications, there is marginal increased cost. However, I do recognize that additional capacity may be needed in order to run the new solutions (memory, cores, storage), and Linux as an OS does have a cost. In most cases, this cost will be far less then acquiring and provisioning a new server.
In many cases, the new solution areas (i.e., Redis Labs and Mongo) are optimized for performance on the Power Systems.
Linux distribution choices for Power Systems include RedHat, S– USE, Ubuntu, Debian and possibly CentOS, which is coming. These are all supported by either IBM or the distributor.
Infrastructure tools like PowerVC run on Linux, and seem to be the strategic direction for "cloud" and provisioning on Power Systems. As time progresses, tools such as CHEF, Docker, and Heat, will possibly become the standards for templates and application provisioning. This is all Linux based.
Cost reduction or savings may be enabled with Linux, since all Linux applications from IBM that run on Power Linux have a PVU of 70 compared to a PVU of up to 120, when running on IBM i. Consider if a WebSphere instance needs to be implemented or expanded: The cost of running WebSphere in a Linux partition would be considerably less than running WebSphere in an IBM i partition, due to the lower cost of Linux over IBM I, and lower PVU rating of WebSphere on Linux.
Some key applications are enabling the advancements based uniquely on the Linux platform. SAP HANA is an example of this.
Skills for Linux are plentiful due to the growth and popularity of the environment. There is Linux education available, as well as Linux on Power education, from several sources.
Linux on Power utilizes skills and processes already in the IBM i shop since it is the same POWER system, the same PowerVM, the same devices, and the same support from IBM.


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text:
"CENTENNIAL" (1978-79) – Episode Two "The Yellow Apron" Commentary
Set during the 1810s and 1820s, the second episode of the NBC miniseries, "CENTENNIAL", continued the story of French-Canadian trapper, Pasquinel; his Scottish-born partner, Alexander McKeag; and their relationship with Clay Basket, the daughter of an Arapaho warrior. "The Yellow Apron" explored how jealousies, resentments and desire nearly broke apart their tenuous relationship.
"The Yellow Apron" began in 1809, with Clay Basket giving birth to the first of hers and Pasquinel's three children, Jacques. The story quickly jumped to 1811, with the birth of their second child, Marcel. By the time the story begins in earnest in 1816, Pasquinel is still obsessed in finding the gold that Lame Beaver had stumbled upon in the last episode. Because of his obsession, he asks McKeag to make the visit to the Bockweiss household in St. Louis for more goods to trade with the Plains tribes. Upon his arrival in St. Louis, McKeag learns that Bockweiss is anxious over his son-in-law's failure to make the trip. He also learns that Lise Bockweiss Pasquinel has given birth to Pasquinel's daughter, Lisette. And all of this happened within the episode's first nine to ten minutes.
So much occurred in "The Yellow Apron". The episode saw the birth of Pasquinel's four children – his children by Clay Basket (Jacques, Marcel and Lucinda) and his daughter by Lise (Lisette). McKeag has to deal with Jacques' dislike of the Scots trapper and suspicion of Clay Basket's love for him. Clashes with both the Native American world and the white world leave scars on Jacques, deepening his dislike of McKeag and leaving a mark on his psyche. Both McKeag and Clay Basket continue their struggle to keep their feelings for one another in check. And both have to contend with Pasquinel's desire for gold and his penchant for leaving them all behind in order to be with his St. Louis wife, Lise. And Lise has to struggle between her own love for the French-Canadian trapper and her growing jealousy for his love of the West and a suspicion that he may have Native American wife. And although he seems very fond of Clay Basket, it is obvious that he is more divided by his feelings for Lise, the West and his desire for gold.
The episode's last half hour spirals into a series of heartbreaking and bittersweet events. Jacques tries to kill McKeag in a fit of anger over a dispute regarding beaver traps. After the attack, McKeag leaves Pasquinel and the latter's Arapaho family. After spending a winter inside a hut encased by a snowdrift, McKeag hooks up with a group of trappers that include Jim Bridger and James Beckwourth. They travel to a rendezvous for other mountain men. There, McKeag has an emotional reunion with Pasquinel. But McKeag's lingering resentment toward his former partner makes the reunion short-lived. After one last trip to St. Louis, Lise convinces McKeag to reconcile with Pasquinel. Unfortunately, McKeag's efforts to reconcile with his former partner come too late. Minutes earlier, Pasquinel is attacked and killed by a band of Ute warriors after finding the gold he had sought for so long. Despite the tragedy, McKeag and Clay Basket are now free to be together. And the Scots trapper agrees to claim Lucinda as his own. The episode ended with a shot of the gold nuggets that Pasquinel finally discovered, but failed to claim as his own due to his death. However, that final shot struck an ominous note . . . as conveying to the audience that not only will the nuggets be discovered again, but also bring havoc to the region. Especially for Pasquinel's Arapaho family and other Native Americans.
I must admit that I found "The Yellow Apron" is probably one of the most bittersweet episodes in this miniseries. And possibly one of the most epic. The latter is not surprising, considering that most of the episode spans nearly fifteen years. But what I really enjoyed about it was that it touched upon an era of the Old West that is rarely covered in Hollywood films or television. I say . . . rarely. There have been movies about trappers and mountain men of the early 19th century, but most Hollywood productions tend to focus upon the West between the 1840s and the 1880s. The episode featured the growing conflict between the Native Americans and whites (both mountain men and the military) that set foot on their lands. This conflict was apparent in an effective scene in which McKeag, Pasquinel and the latter's Arapaho family visited a fort along the Missouri River, where they clash with a group of hostile American soldiers. Viewers also had an opportunity to enjoy a scene that featured a rendezvous between trappers and traders from many nations and Native Americans. Thanks to some detailed and colorful direction by Virgil W. Vogel, the scene not only went into detail over what transpired at a rendezvous – trading, horse and foot racing, target shooting, singing, dancing, gambling and other activities.
A yellow apron figured into a session of dancing, initiated by a mountain man playing a bag pipe. This incident led to an emotional reunion between Pasquinel and McKeag. Considering the acrimony (at least on McKeag's part) that led to their separation, watching the two former friends dance away the bitterness proved to be one of the most poignant moments in the entire miniseries. The scene also proved to be one of the finest moments on screen for both Richard Chamberlain and Robert Conrad. In fact, this particular episode provided some of the best acting in the entire miniseries. Not only did Chamberlain and Conrad did some of their best work, so did the likes of Barbara Carrera and Sally Kellerman, who both did excellent jobs in conveying the emotional difficulties in being Pasquinel's wife. I also have to commend the late Vincent Roberts' portrayal of Jacques Pasquinel in his early teens. I thought he did a top notch job of conveying the young Jacques' dislike and resentment toward McKeag without resorting to any over-the-top acting.
Directed by Virgil Vogel, "The Yellow Apron" is without a doubt, one of my favorite episodes in the miniseries. Personally, I thought it conveyed the complex friendship between Pasquinel and Alexander McKeag with more depth than even "Only the Rocks Live Forever". Not only did it boast some first-rate performances, especially from Richard Chamberlain and Robert Conrad, but also provided one of the most memorable scenes in the entire miniseries.
Filed under: Book Review, Essay, Television | Tagged: antebellum, barbara carrera, carl franklin, centennial, chief dan george, david janssen, early america, history, karen carlson, kario salem, old west, raymond burr, richard chamberlain, robert conrad, robert easton, sally kellerman, stephen mchattie, television, virgil w. vogel, war of 1812 |
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Whisk together olive oil, balsamic vinegar, blackberry preserves, shallot, mustard, salt and pepper. Set aside.
In pot of simmering water, cook eggs for 12 minutes. Place under cold running water until eggs are cool enough to handle. Peel and slice into 1/4-inch-thick slices; set aside.
In large bowl, toss spinach with vinaigrette. Gently stir in blackberries and eggs; divide among four plates. Garnish with goat cheese and slivered almonds.


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