text:
The next generation of antimalarials
by Abi Millar August 1, 2018 November 30, 2018
Leave a Comment on The next generation of antimalarials
Novartis has launched a programme to add novel treatments to its malaria pipeline and to complete clinical trials for two new candidates. So why are new antimalarials needed? Abi Millar finds out.
Over the last two decades, the fight against malaria has been overwhelmingly successful. Between 2000 and 2015, global malaria deaths fell by more than 60%, largely thanks to better vector control, for example via insecticides, and advances in treatment.Unfortunately, the disease remains an enormous healthcare burden, with nearly half the world's population at risk of infection. In 2016, there were 216 million reported cases of malaria, claiming the lives of 445,000 people. More than two thirds of these malaria deaths (285,000) occurred in children under five.
On top of this, a number of African nations lack the capacity to develop healthcare systems that can deliver appropriate treatment and care.
"A recent study, which pooled data from 33 African countries, estimated that only about a fifth of children with a malaria-induced fever currently receive the right diagnosis and appropriate treatment," says Dr Harald Nusser, head of Novartis Social Business. "A child dies every two minutes from malaria."
He points out that, despite the fall in mortality rates, now is not the time for the medical community to lose momentum.
"If we continue to be successful in the fight against malaria, complacency will set in as the number of cases and deaths continues to decrease," he says. "Global attention will be diverted onto other illnesses, not least noncommunicable diseases, which are rapidly increasing in many African countries."
Novartis' investment
Attuned to this threat, Novartis recently announced a renewed commitment to combating the disease. Speaking at the Malaria Summit in London in April, the company said it plans to invest more than $100m in R&D over the next five years. Ultimately, it hopes to develop next-generation antimalarials that could treat the condition in a completely different way.
"The company will also implement an equitable pricing strategy adapted to maximise patient access in malaria-endemic countries when these new treatments become available," adds Nusser. "It will further help expand access to paediatric antimalarials and implement healthcare system strengthening programmes in four sub-Saharan countries heavily affected by malaria, including Nigeria and the Democratic Republic of the Congo."
Novartis already has a strong track record in antimalarials. In the early 1990s, the company began to look at underserved areas in global health, giving rise to the Novartis Malaria Initiative.
"In 1994, a joint venture between Novartis and Chinese partners was agreed to develop, test and manufacture an antimalarial treatment – the first collaboration of its kind in Chinese history. This led to the development of the world's first fixed-dose artemisinin-based combination therapy (ACT)," says Nusser.
Following a landmark agreement with the World Health Organization (WHO) in 2001, Novartis committed to making this ACT available without profit to the public sector of malaria-endemic countries. Although this agreement expired in 2011, the company continues to provide treatments on the same terms.
"So far, more than 850,000 treatments have been distributed without profit," Nusser explains.
Acts of resistance
As recommended by WHO, ACTs remain the first line of treatment for uncomplicated malaria. Since they combine two active ingredients with different mechanisms of action, they approach the disease from a dual angle, representing a key step up in malaria treatment.
To give some context of their development, the 1980s and 1990s saw the emergence of resistance to earlier therapies (chloroquine and then sulphadoxine-pyrimethamine). This is thought to have contributed to rising malaria mortality throughout the 90s.
"The Institute of Health Metrics and Evaluation at the University of Washington, which provides estimates of malaria deaths, shows mortality increasing from around 746,000 in 1990 to reach a peak of over 990,000 in 2003," says Nusser. "Many experts believe that this increase in mortality was due to the emergence of treatment resistance, with insecticide resistance also being a strong contributor."
Since the introduction of ACTs and widespread bed net use, great progress has been made. Unfortunately, history could be set to repeat itself as the pathogens continue to mutate. Cases of ACT-resistant malaria have been seen in the Greater Mekong Region, prompting concerns that it could spread further around Asia and on to Africa.
"In addition, some experts believe that de novo ACT resistance in Africa is also possible. Widespread ACT resistance would have a devastating impact on the global capacity to treat malaria," says Nusser. "That is why Novartis is working with partners to develop successor treatments so that we will be ready when that day comes."
This article appears in the August 2018 edition of Pharma Technology Focus
Tags: antimalrials malaria Novartis
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text:
import rospy
import genpy
from std_srvs.srv import Empty
import yaml
from bson import json_util, Binary
import json

import copy
import StringIO
from mongodb_store_msgs.msg import SerialisedMessage
from mongodb_store_msgs.srv import MongoQueryMsgRequest

import importlib

def wait_for_mongo():
    """
    Waits for the mongo server, as started through the mongodb_store/mongodb_server.py wrapper

    :Returns:
        | bool : True on success, False if server not even started.
    """
    # Check that mongo is live, create connection
    try:
        rospy.wait_for_service("/datacentre/wait_ready",10)
    except rospy.exceptions.ROSException, e:
        rospy.logerr("Can't connect to MongoDB server. Make sure mongodb_store/mongodb_server.py node is started.")
        return False
    wait = rospy.ServiceProxy('/datacentre/wait_ready', Empty)
    wait()
    return True

def check_for_pymongo():
    """
    Checks for required version of pymongo python library.

    :Returns:
        | bool : True if found, otherwise Fale
    """
    try:
        import pymongo
    except:
        print("ERROR!!!")
        print("Can't import pymongo, this is needed by mongodb_store.")
        print("Make sure it is installed (sudo pip install pymongo)")
        return False

    return True

"""
Pick an object to use as MongoClient based on the currently installed pymongo
version. Use this instead of importing Connection or MongoClient from pymongo
directly.

Example:
    MongoClient = util.importMongoClient()
"""
def import_MongoClient():
    import pymongo
    if pymongo.version >= '2.4':
        def mongo_client_wrapper(*args, **kwargs):
            return pymongo.MongoClient(*args, **kwargs)
        return mongo_client_wrapper
    else:
        import functools
        def mongo_client_wrapper(*args, **kwargs):
            return pymongo.Connection(*args, **kwargs)
        return functools.partial(mongo_client_wrapper, safe=True)

"""
Given a ROS msg and a dictionary of the right values, fill in the msg
"""
def _fill_msg(msg,dic):
    for i in dic:
        if isinstance(dic[i],dict):
            _fill_msg(getattr(msg,i),dic[i])
        else:
            setattr(msg,i,dic[i])

"""
Given a document in the database, return metadata and ROS message -- must have been
"""
def document_to_msg_and_meta(document, TYPE):
    meta = document["_meta"]
    msg = TYPE()
    _fill_msg(msg,document["msg"])
    return meta,msg

"""
Given a document return ROS message
"""
def document_to_msg(document, TYPE):
    msg = TYPE()
    _fill_msg(msg,document)
    return meta

def msg_to_document(msg):
    """
    Given a ROS message, turn it into a (nested) dictionary suitable for the datacentre.

    >>> from geometry_msgs.msg import Pose
    >>> msg_to_document(Pose())
    {'orientation': {'w': 0.0, 'x': 0.0, 'y': 0.0, 'z': 0.0},
    'position': {'x': 0.0, 'y': 0.0, 'z': 0.0}}

    :Args:
        | msg (ROS Message): An instance of a ROS message to convert
    :Returns:
        | dict : A dictionary representation of the supplied message.
    """

    d = {}

    slot_types = []
    if hasattr(msg,'_slot_types'):
        slot_types = msg._slot_types
    else:
        slot_types = [None] * len(msg.__slots__)

    for (attr, type) in zip(msg.__slots__, slot_types):
        d[attr] = sanitize_value(attr, getattr(msg, attr), type)

    return d

def sanitize_value(attr, v, type):
    """
    De-rosify a msg.

    Internal function used to convert ROS messages into dictionaries of pymongo insertable
    values.

    :Args:
        | attr(str): the ROS message slot name the value came from
        | v: the value from the message's slot to make into a MongoDB able type
        | type (str): The ROS type of the value passed, as given by the ressage slot_types member.
    :Returns:
        | A sanitized version of v.
    """

        # print '---'
        # print attr
        # print v.__class__
        # print type
        # print v

    if isinstance(v, str):
        if type == 'uint8[]':
            v = Binary(v)
        else:
            # ensure unicode
            try:
                v = unicode(v, "utf-8")
            except UnicodeDecodeError, e:
                # at this point we can deal with the encoding, so treat it as binary
                v = Binary(v)
        # no need to carry on with the other type checks below
        return v

    if isinstance(v, rospy.Message):
        return msg_to_document(v)
    elif isinstance(v, genpy.rostime.Time):
        return msg_to_document(v)
    elif isinstance(v, genpy.rostime.Duration):
         return msg_to_document(v)
    elif isinstance(v, list):
        result = []
        for t in v:
            if hasattr(t, '_type'):
                result.append(sanitize_value(None, t, t._type))
            else:
                result.append(sanitize_value(None, t, None))
        return result
    else:
        return v

def store_message(collection, msg, meta, oid=None):
    """
    Update ROS message into the DB

    :Args:
        | collection (pymongo.Collection): the collection to store the message in
        | msg (ROS message): an instance of a ROS message to store
        | meta (dict): Additional meta data to store with the ROS message
        | oid (str): An optional ObjectID for the MongoDB document created.
    :Returns:
        | str: ObjectId of the MongoDB document.
    """
    doc=msg_to_document(msg)
    doc["_meta"]=meta
    #  also store type information
    doc["_meta"]["stored_class"] = msg.__module__ + "." + msg.__class__.__name__
    doc["_meta"]["stored_type"] = msg._type

    if hasattr(msg, '_connection_header'):
        print getattr(msg, '_connection_header')

    if oid != None:
        doc["_id"] = oid

    return collection.insert(doc)

# """
# Stores a ROS message into the DB with msg and meta as separate fields
# """
# def store_message_separate(collection, msg, meta):
#     doc={}
#     doc["_meta"]=meta
#     doc["msg"]=msg_to_document(msg)
#     return collection.insert(doc)

def store_message_no_meta(collection, msg):
    """
    Store a ROS message sans meta data.

    :Args:
        | collection (pymongo.Collection): The collection to store the message in
        | msg (ROS message): An instance of a ROS message to store
    :Returns:
        | str: The ObjectId of the MongoDB document created.
    """
    doc=msg_to_document(msg)
    return collection.insert(doc)

def fill_message(message, document):
    """
    Fill a ROS message from a dictionary, assuming the slots of the message are keys in the dictionary.

    :Args:
        | message (ROS message): An instance of a ROS message that will be filled in
        | document (dict): A dicionary containing all of the message attributes

    Example:

    >>> from geometry_msgs.msg import Pose
    >>> d = dcu.msg_to_document(Pose())
    >>> d['position']['x']=27.0
    >>> new_pose = Pose(
    >>> fill_message(new_pose, d)
    >>>  new_pose
    position:
      x: 27.0
      y: 0.0
      z: 0.0
    orientation:
      x: 0.0
      y: 0.0
      z: 0.0
      w: 0.0
    """
    for slot, slot_type in zip(message.__slots__,
                               getattr(message,"_slot_types",[""]*len(message.__slots__))):
        value = document[slot]
        # fill internal structures if value is a dictionary itself
        if isinstance(value, dict):
            fill_message(getattr(message, slot), value)
        elif isinstance(value, list) and slot_type.find("/")!=-1:
            # if its a list and the type is some message (contains a "/")
            lst=[]
            # Remove [] from message type ([:-2])
            msg_type = type_to_class_string(slot_type[:-2])
            msg_class = load_class(msg_type)
            for i in value:
                msg = msg_class()
                fill_message(msg, i)
                lst.append(msg)
            setattr(message, slot, lst)
        else:
            if isinstance(value, unicode):
                setattr(message, slot, str(value))
            else:
                setattr(message, slot, value)

def dictionary_to_message(dictionary, cls):
    """
    Create a ROS message from the given dictionary, using fill_message.

    :Args:
        | dictionary (dict): A dictionary containing all of the atributes of the message
        | cls (class): The python class of the ROS message type being reconstructed.
    :Returns:
        An instance of cls with the attributes filled.

    Example:

    >>> from geometry_msgs.msg import Pose
    >>> d = {'orientation': {'w': 0.0, 'x': 0.0, 'y': 0.0, 'z': 0.0},
       'position': {'x': 27.0, 'y': 0.0, 'z': 0.0}}
    >>> dictionary_to_message(d, Pose)
    position:
      x: 27.0
      y: 0.0
      z: 0.0
    orientation:
      x: 0.0
      y: 0.0
      z: 0.0
      w: 0.0
    """
    message = cls()
    fill_message(message, dictionary)
    return message

def query_message(collection, query_doc, find_one):
    """
    Peform a query for a stored messages, returning results in list.

    :Args:
        | collection (pymongo.Collection): The collection to query
        | query_doc (dict): The MongoDB query to execute
        | find_one (bool): Returns one matching document if True, otherwise all matching.
    :Returns:
        | dict or list of dict: the MongoDB document(s) found by the query
    """

    if find_one:
        ids = ()
        result = collection.find_one(query_doc)
        if result:
            return [ result ]
        else:
            return []
    else:
        return [ result for result in collection.find(query_doc) ]

def update_message(collection, query_doc, msg, meta, upsert):
    """
    Update ROS message in the DB, return updated id and true if db altered.

    :Args:
        | collection (pymongo.Collection): The collection to update in
        | query_doc (dict): The MongoDB query to execute to select document for update
        | msg (ROS message): An instance of a ROS message to update to
        | meta (dict): New meta data to update the stored message with
        | upsert (bool): If message does not already exits, create if upsert==True.
    :Returns:
        | str, bool: the OjectId of the updated document and whether it was altered by
                     the operation
    """
    # see if it's in db first
    result = collection.find_one(query_doc)

    # if it's not in there but we're allowed to insert
    if not result:
        if upsert:
            return store_message(collection, msg, meta), True
        else:
            return "", False

    # convert msg to db document
    doc=msg_to_document(msg)

    #update _meta
    doc["_meta"] = result["_meta"]
    #merge the two dicts, overwiriting elements in doc["_meta"] with elements in meta
    doc["_meta"]=dict(list(doc["_meta"].items()) + list(meta.items()))

    # ensure necessary parts are there too
    doc["_meta"]["stored_class"] = msg.__module__ + "." + msg.__class__.__name__
    doc["_meta"]["stored_type"] = msg._type

    return collection.update(query_doc, doc), True

def query_message_ids(collection, query_doc, find_one):
    """
    Peform a query for a stored message, returning a tuple of id strings

    :Args:
        | collection (pymongo.Collection): The collection to search
        | query_doc (dict): The MongoDB query to execute
        | find_one (bool): Find one matching document if True, otherwise all matching.
    :Returns:
        | tuple of strings: all ObjectIds of matching documents
    """
    if find_one:
        result = collection.find_one(query_doc)
        if result:
            return str(result["_id"]),
    else:
        return tuple(str(result["_id"]) for result in collection.find(query_doc, {'_id':1}))

def type_to_class_string(type):
    """
    Takes a ROS msg type and turns it into a Python module and class name.

    E.g

    >>> type_to_class_string("geometry_msgs/Pose")
    geometry_msgs.msg._Pose.Pose

    :Args:
        | type (str): The ROS message type to return class string
    :Returns:
        | str: A python class string for the ROS message type supplied
    """
    parts = type.split('/')
    cls_string = "%s.msg._%s.%s" % (parts[0], parts[1], parts[1])
    return cls_string

def load_class(full_class_string):
    """
    Dynamically load a class from a string
    shamelessly ripped from: http://thomassileo.com/blog/2012/12/21/dynamically-load-python-modules-or-classes/

    :Args:
        | full_class_string (str): The python class to dynamically load
    :Returns:
        | class: the loaded python class.
    """
    # todo: cache classes (if this is an overhead)
    class_data = full_class_string.split(".")
    module_path = ".".join(class_data[:-1])
    class_str = class_data[-1]
    module = importlib.import_module(module_path)
    # Finally, we retrieve the Class
    return getattr(module, class_str)

def serialise_message(message):
    """
    Create a mongodb_store_msgs/SerialisedMessage instance from a ROS message.

    :Args:
        | message (ROS message): The message to serialise
    :Returns:
        | mongodb_store_msgs.msg.SerialisedMessage: A serialies copy of message
    """
    buf=StringIO.StringIO()
    message.serialize(buf)
    serialised_msg = SerialisedMessage()
    serialised_msg.msg = buf.getvalue()
    serialised_msg.type = message._type
    return serialised_msg

def deserialise_message(serialised_message):
    """
    Create a ROS message from a mongodb_store_msgs/SerialisedMessage

    :Args:
        | serialised_message (mongodb_store_msgs.msg.SerialisedMessage): The message to deserialise
    :Returns:
        | ROS message: The message deserialised
    """
    cls_string = type_to_class_string(serialised_message.type)
    cls = load_class(cls_string)
    # instantiate an object from the class
    message = cls()
    # deserialize data into object
    message.deserialize(serialised_message.msg)
    return message

def string_pair_list_to_dictionary_no_json(spl):
    """
    Covert a mongodb_store_msgs/StringPairList into a dictionary, ignoring content

    :Args:
        | spl (StringPairList): The list of (key, value) to pairs convert
    :Returns:
        | dict: resulting dictionary
    """
    return dict((pair.first, pair.second) for pair in spl)

def string_pair_list_to_dictionary(spl):
    """
    Creates a dictionary from a mongodb_store_msgs/StringPairList which could contain JSON as a string.
    If the first entry in the supplied list is a JSON query then the returned dictionary is loaded from that.

    :Args:
        | spl (StringPairList): The list of (key, value) pairs to convert
    :Returns:
        | dict: resulting dictionary
    """
    if len(spl.pairs) > 0 and spl.pairs[0].first == MongoQueryMsgRequest.JSON_QUERY:
        # print "looks like %s", spl.pairs[0].second
        return json.loads(spl.pairs[0].second, object_hook=json_util.object_hook)
    # else use the string pairs
    else:
        return string_pair_list_to_dictionary_no_json(spl.pairs)

def topic_name_to_collection_name(topic_name):
    """
    Converts the fully qualified name of a topic into legal mongodb collection name.
    """
    return topic_name.replace("/", "_")[1:]

redpajama_set_name: RedPajamaGithub


text:
That question won't be relevant in another year or so as it will already be agreed between UK and EU.
Perhaps, perhaps not. Ursula von der Leyen held a speech at LSE and she made clear that hurdle free access to the European market and free movement must come together. The UK may opt for a limited access in order to limit EU immigration. It's a double shot in its own leg.
Another requirement are similar standards regarding environment, labour, subsidies… The more the UK wants to move away from EU standards, the more limited will its access to the EU market be.
She also said that it will not be possible to conclude all negotiations by the end of the year and if the UK insists on keeping the deadline a number of aspects of the future relationship will not have been agreed and put into the contract.
Johnson wants a trade deal without alignment of rules and legislation. In that case the UK will have to limit its trade with the EU with all the consequences that the businesses are warning about.
An interesting annoucement from Harry and Meghan. I can only sympathise with the decision they have taken. For their own sakes they need to protect themselves and their relationship… Interesting that they say that they want to earn their own living and forge a progressive path while supporting the Queen. No doubt that Meghan will be blamed.
Rather than being parasites living off the taxpayer and living lives of luxury doing whatever they want… they will actually pay their way.
This is the first step to seeing the monarchy abolished and the Queen replaced with an elected, democratic head of state. The next step will be when the Queen dies and then we are going to have a Monarch the likes of which we haven't seen for many decades.
As we've seen in recent times our monarchical system means politicians, and particularly the Prime Minister, have much more power than they would in a republic. The UK isn't a true democracy and we have a halfway house where the PM with the Executive control the UK in just the same way as Monarchs of old.
Time to rip it apart and replace it.
staggering UK retail sales in 2019
WORST YEAR EVER…
Let's see how its reported in the Tabloids and TV
Retail Gazette – 9 Jan 20
2019 was UK retail's worst year ever - Retail Gazette
Total sales for 2019 decreased by 0.1%, compared with 1.2% growth in 2018, making it the worst year on record. In December, sales increased by 1.9% in December, against a flat 0.0% in December 2018. Taking November & December together to iron out the...
After all, when you accumulate many millions or billions it all becomes meaningless.
In Dubai-- Hard to ignore the money spent but its obscene.
Seems like an huge economy built on encouraging rich to invest and slavery they bring PPL in from 3rd world countries to work with no protection then send them back home.
Is that what the Tories want for us ? increasing number of farm workers to come from non EU countries to work on farms? will they be in chains??
wouldn't invest here for a big clock…
arsanias:
You say that the rhetoric matters more than facts. What do you mean by "positions itself"? What position and how is it related to Brexit? How does Brexit change immigration? You can fool people out there, but not here.
Why is it so difficult for people on this BB to rise above the personal? This isn't about what I think. This is about communicating with the electorate and making them think you take their concerns seriously. When Long-Bailey says on Radio 4 "never again will our party put immigration controls on a mug" (a dig at Ed Milliband) or that uncontrolled immigration does not suppress wages who exactly do you think she is trying to win over or impress? Is it the electorate in the red wall constituencies that Labour got slaughtered in? Is it f**k. Language matters. Tone matters.
As for Brexit, the impact on immigration will be what the government want it to be which is relatively negligible. This government is pro-immigration (as am I and I never voted for Brexit for that reason). They understand though that talking tough and acting soft is the way forward. Labour just cannot seem to get it. I honestly don't know what it is going to take for it to sink in.
They understand though that talking tough and acting soft is the way forward
It is the way to getting slaughtered in the next election. Once left the EU, why would those northern seats ever vote for a Tory government again? They will soon see they are pro-immigration and anti everyone outside the south east and that will be backed by falling standards of living, rising inflation and unemployment rates.
Unfortunately, Labour don't have to change, they can just stay as shit as they are and wait for Boris to hand them power.
Huw,
I mostly agree with your post and specifically that "tone" matters. But so too does honesty. The Brexit Brigade and its RW support in the press ramped up immigration as an issue during the referendum and continues to do so to this day. Is it any surprise that in this toxic atmosphere that Harry and Meghan want to withdraw from the firing line?
There is a problem with the RW weaponising immigration and by doing so legitimising racist sentiment. As always, the truth is far more complicated. As you acknowledge, Brexit won't do much to reduce immigration. If we have shortages in some areas then necessarily workers will be imported. In this context it is hard to imagine anything more stupid than the Tory decision to end bursaries for nurses who work in a modestly paid profession. Some of us predicted the consequences. Not too difficult really.
But what has been the effect on wages? According to Full Fact, it has mainly affected low paid occupations shaving off a half of one percent off wage rates. Almost certainly the "minimum wage" has had a bigger effect on the downside as well as the upside.
What does immigration do to wages?
It depends who you are.
When times are tough many look to pull up the drawbridges to protect against the outsiders. This is what has happened since 2010 as a result of the largely unnecessary and ideological austerity programme. That certainly did reduce wages for many but Labour has been very poor at explaining that and, indeed, that it did not cause the banking crisis.
What we need is for our politicians to tell the truth rather than find "letterbox" and "piccaninny" scapegoats. We have seen what that led to in 1930's Germany.
I accept that you did not vote Leave on the grounds of immigration but many did. Certainly the xenophobic tone of the Brexit campaign made it absolutely certain that I would not have voted for it. You have to make your own chaice about which red lines you are prepared to step over.
Sir_Buns-Up_Knealing 2020-01-09 09:26:54 UTC #26964
Apart from footballers I guess you are the only Merseysider in Dubai right now?
Bit of a culture shock for you. But just think of the opportunities with all them smart, expensive cars about with nice, shiny, collectable hubcaps.
IMHO,
Is it any surprise that in this toxic atmosphere that Harry and Meghan want to withdraw from the firing line?
The 2 things have nothing to do with each other.
This is not important, it is about perception. People think there is a problem so if you want their votes you need to listen to their concerns and appear to address them.
Labour has been very poor at explaining that and, indeed, that it did not cause the banking crisis
Labour needs to drop its fixation with identity politics and start talking in a language that people want to hear. If it can't or won't do that it cannot win elections.
I don't particularly care, but two fewer grasping leeches is always welcome. I wish them well in their noble quest for financial independence and look forward to receiving a rebate for their mental wedding, ludicrous home renovations, and the two month holiday that they used to pull off this little ruse.
They've already produced "progressive manifestos" ffs. A couple who spends money like water and uses planes like most people take buses is going to put us all straight on where we're going wrong in life. But as long as I'm not paying, you crack on, love. There's definitely more than enough credulous idiots out there to listen and make you both obscenely rich.
You do have to hand it to them (her) though. Announcing that you intend to "continue to collaborate" with your own nan is elite level sh!thousery effectively relegating the Queen to Beats by Dre status.
They said they plan to balance their time between the UK and North America
Using Greta's eco-yacht and "cough" in a bucket each time, I presume? Surely they won't be flying backwards and forwards using ghastly hydrocarbons? Not in the middle of the climate emergency that they've been warning us all about?!
I would say that they absolutely are connected. The RW popular press is utterly racist in its tone and Meghan has been a target because of this. The Mail and the Express are utterly toxic.
It has absolutely nothing to do with race. They are from a bygone age in which they think they ought to be able bully the media into telling only happy, agreeable stories about royal personages. People dislike Meghan Markle because she is a woke snob who wants to lecture the public on everything from climate change to feminism. The royals think they should be above any criticism. They use the press as a self promotional tool and then cry foul at the slightest criticism.
This is about communicating with the electorate and making them think you take their concerns seriously.
They understand though that talking tough and acting soft is the way forward.
So, what you mean is, it is about saying one thing, but doing something else?
That's how you get votes of Brexiteers? Perhaps that works with stupid people…
Perhaps it does but as you lot keep telling me most of the people in this country are stupid, if Labour want to win they better learn how to start communicating with them.
Says more about you than her.
People dislike Meghan Markle because she is a woke snob who wants to lecture the public on everything from climate change to feminism.
Ah, maybe the thicko Leave voter types who want to be told about the myth of climate change, that mixed race couples should not have kids and women should know their place. Good old fashioned British values in fact.
Perhaps you are a climate change denier Huw?
And also an anti-feminist who would be greatly at home in Cyprus?
I don't care if Labour wins. I care about politicians that act reasonably. If I remember right, Tories were pro EU and Labour against. Even the press was for joining. But later the EU never had many advocates in the UK. It was always tempting to blame the EU or spread lies - and for some it was simply fun - as Johnson once admitted.
The UK will change its perception of the EU once it has left. There is this big political and economic union at your doorstep and you decided to leave while all others want to join or are de facto members. It's like leaving the house and looking at the lighted windows from the dark hearing the chatter from inside.
Your default response to inconvenient truths Frog. I'm neither of those things but I do have a problem with people who fly all over the world and leave a carbon footprint the size of Wales ramming it down my throat. What exactly is so difficult for you to understand about that? Is it simply that you have to leave the comfort blanket of your "everyone is a racist and everything they do is motivated by racism" bunker?

redpajama_set_name: RedPajamaCommonCrawl


text:
André Lurquin (Doornik, 27 augustus 1961) is een Belgisch voormalig professioneel wielrenner. Hij reed voor onder meer Lotto. Lurquin werd in 1983 wereldkampioen op de ploegenachtervolging bij de militairen.

Hij behaalde verder geen overwinningen.

Belangrijkste overwinningen

1983
  Wereldkampioen ploegenachtervolging, Militairen (met Eric Vanderaerden, Michel Dernies en Eric Lammers)

Resultaten in voornaamste wedstrijden

|
|}

Externe link

Lurquin, Andre

redpajama_set_name: RedPajamaWikipedia


it's a old wall but i have updates this.
I think I'll fav this one even though I'm not a Naruto fan, cause the background fits just so well with the scan.
I'd like to know how you did all this.
There is just the font in wich Naruto is written that I less like, a more grunge font would be nice.
Yeah, I totaly agree. The bg is awsome as is the scan. Excellent job!
haha this wallpaper totally cracks me up, don't know why. good work and keep it going!
This wall is very nice but I agree that the font used on the wall should be something more dirty like Naruto. Otherwise, great job love it and thanks for sharing.
lmfao I love it! Especially the little lollipops stuck in his headband. (That is what they are, right? :O) Wonderful job here, just lovely. Keep up the great work!
Very nice wallpaper. The background is so nice. I like the colors so much.
nice wallpaper. I love it!
THXXXX So good this wallpaperrr ! I love Narutoooooooo ! ! ! !
GOOOOOOOOOOOOODDDD |! | | THX !
Very nice wallpaper. The background is so nice.


text:
El Instituto de Tecnología Rose-Hulman (en inglés Rose-Hulman Institute of Technology) es una institución de educación superior  en Terre Haute, Indiana que especializa en enseñar ingeniería, ciencia, y matemáticas.

Graduados destacados
 Ernest R. Davidson (1958), químico, galardonado con la Medalla Nacional de Ciencia.
 Lawrence Giacoletto (1938), pionero en el campo de los transistores.
 John Hostettler (1983), Congresista de Estados Unidos.
 Curtis Huttenhower (2000), catedrático en Harvard, experto en biología computacional.
 Don Lincoln (1986), físico de partículas.
 Chris Mack (1982), reconocido experto en litografía.
 Abe Silverstein (1929), ingeniero aeroespacial, director en la NASA y ganador de la medalla Guggenheim.
 Mat Roy Thompson (1891), ingeniero civil famoso por ser el constructor jefe del castillo de Scotty.
 Jim Umpleby (1980), consejero delegado de Caterpillar.
 Bernard Vonderschmitt (1944), ingeniero eléctrico, cofundador de Xilinx.
 Michael Mussallem (1974), ingeniero químico, director ejecutivo de Edwards Lifesciences.
 Niles Noblitt (1973), ingeniero biológico, cofundador de Biomet.
 Robert L. Wilkins (1986), juez, Tribunal Superior del Distrito de Columbia.

Universidades de Indiana
Universidades técnicas de Estados Unidos
Instituciones educativas establecidas en 1874
Universidades de Estados Unidos fundadas en el siglo XIX
Estados Unidos en 1874


Do a little dance with me - it's my 100th post! I've had a blast sharing my thoughts, reviews and recipes with the interwebs and have lots more coming, but tonight...oh tonight we celebrate! What better way to celebrate than with a gluten-free giveaway of epic proportions? Ok, maybe not EPIC, but this is seriously one of the better prizes I've given away and I'm not really looking forward to the shipping charges, haha!
Ok, I think the suspense is enough, on to the prize! To celebrate my 100th post, I'm giving away a Kinnikinnick gift basket LOADED with gluten-free goodies lovingly provided by Kinnikinnick (my favorite Canadians). It's a prize valued at $35 and it's all yours...if you win, of course!
To enter, all you have to do is post a comment telling me what your favorite Kinnikinnick product is, or if you haven't tried any of their stuff before, tell me which of their products sounds yummy.
Get 2 entries by following me on Twitter and posting a comment below with your Twitter name and your Kinnikinnick pick.
Get 3 entries by by following me on Twitter, following Kinnikinnick on Twitter and posting a comment below with your Twitter name and your Kinnikinnick pick.
Get 4 entries by doing all of the above AND subscribing to my YouTube channel & posting a comment on my YouTube page.
Enter by 11:59 PM ET on October 15th. Winner will be selected randomly and announced by Monday, October 18th. Giveaway open to US residents only. Misterbelly.com does not guarantee condition of product upon receipt. Good luck!
Check out my video review of some of my favorite Kinnikinnick products!
*Update: The winner for the giveaway is Angela Datre! Thank you to everyone that entered! I do monthly giveaways, so please keep checking back and enter again for another prize!


text:
How many Computer Programmers and Interactive Media Developers are employed part-time?
4% of Computer Programmers and Interactive Media Developers are employed only on a part-time basis. There were 113,300 workers employed in these occupations in 2004, an increase of 8% since 1997.
What is a day in the life of a Computer Programmers and Interactive Media Developers like?
Computer programmers perform some or all of the following duties: A. Program animation software to predefined... more
What education do you need to become a Computer Programmers and Interactive Media Developers?
1. A bachelor's degree in computer science or in another discipline with a significant programming component or... more
What is the current Job Outlook for a Computer Programmers and Interactive Media Developers?
The job outlook for Computer Programmers and Interactive Media Developers is considered Average because: 1.... more
What is the future Job Outlook for a Computer Programmers and Interactive Media Developers?
Your job outlook will continue to be Average because: 1. Enrolment in the fields of study related to this... more
How much does a Computer Programmers and Interactive Media Developers make?
The average hourly wages for Computer Programmers and Interactive Media Developers is $26.56/HR, which is close to... more
What is the currently unemployment rate for a Computer Programmers and Interactive Media Developers"?
4% of Computer Programmers and Interactive Media Developers are unemployed. This rate is above the average for... more
How many Computer Programmers and Interactive Media Developers are self-employed?
Roughly 14% of Computer Programmers and Interactive Media Developers are self-employed. This is considered Average... more
What is the average age of a Computer Programmers and Interactive Media Developers?
A Day in the Life of a Computer Programmer
Education required to Become an Artist
Graphic Design, Game Design and Web
Information on Computer Careers


text:
INTERNATIONAL: 911 calls detail Texas mom fatally shooting daughters as they begged 'please don't shoot'
By New York Daily News
NEW YORK DAILY NEWS – Horrific 911 calls made from the frightened siblings shot dead by their crazed mother in Texas — as well as a neighbor who watched it happen — detail Taylor and Madison Sheats' final moments as they begged for their lives.
"Please don't point the gun at us," cried the victims, 17 and 22, who were shot dead by their mother, Christy Sheats, at their Katy home in the Houston suburbs.
The distraught sisters were heard in mostly unintelligible 911 calls released by Fort Bend County Sheriff's Office on Tuesday, capturing their desperate pleas during a doomed family meeting Friday.
"Please don't shoot," and "Don't do it," were among the cries heard.
The dispatcher repeatedly asked "Hello," but the girls and their father, Jason Sheats, never responded.
CLICK HERE FOR FULL STORY
Ebola outbreak in Congo declared an international health emergency: WHO
INTERNATIONAL: Texas mother killed by police after fatally shooting her two daughters during 'family argument' (3)
Texas emergency operator jailed for 911 call hang ups (0)
U.S: 9-year-old boy accidentally shot dead by 9-year-old cousin in Houston (0)
INTERNATIONAL: Homeowner shoots two burglars who broke into his house in Oklahoma (7)
Charred remains found of family who vanished before son's birthday party (0)
Woman says boyfriend beat, raped her in months-long ordeal (3)


text:
Corbyn Could Leave Britain Without Opposition
The Labour Party leader will make it impossible to conduct opposition if he continues to refuse to step down.
Nick Ottens July 3, 2016 November 23, 2021
If Labour Party leader Jeremy Corbyn continues to stay put despite losing the support of his lawmakers, he not only risks splitting his party; he could leave the United Kingdom without an effective opposition for months.
Corbyn, an unreformed socialist, won his party's leadership election last year with almost no support from his parliamentary colleagues.
His failure to persuade a larger share of Labour voters to follow the party line and vote "remain" in last week's European Union referendum was the final straw for lawmakers who rightly fear they are doomed if Corbyn stays on as leader. Polls predict an historic defeat.
172 against forty expressed their lack of confidence in Corbyn on Tuesday. Most of his shadow cabinet walked out. Former party leaders publicly called on Corbyn to resign.
Corbyn ignored all this, insisting that he has a mandate from ordinary party members to carry on.
If he persists, Labour is almost certainly headed for another leadership election, which could take months to organize.
In the meantime, what happens to the party?
What opposition?
As long as dozens of frontbench positions remain unfilled, parliamentary work could grind to a halt. Questions would no longer be asked. Committees would be half empty.
The rebels, who are in the majority after all, could form a faction of their own and claim official opposition status, but that probably brings the prospect of a definitive split too close for comfort.
The Scottish National Party, the third largest, has already, in jest, applied to be recognized as the opposition instead. Speaker John Bercow rejected their appeal but might change his mind if Corbyn singlehandedly slows down the business of his house.
Until that happens, the Conservatives — who aren't exactly a united party either at the moment — will rule virtually unchallenged.
Europe Jeremy Corbyn Labour Party (UK) United Kingdom Western Europe


Edison Research and Triton Digital have released their Podcast Consumer Canada 2018 report, assessing the audio format's audience and popularity among Canadian listeners. The analysis reveals familiar trends in terms of who is tuning into podcasts most and what their common behaviors are.
Familiarity with the term podcasts was 61% among the 18+ Canadian population, and 47% said they had ever listened to a podcast. Canada had 28% of participants identifying as monthly podcast listeners. The rate leapt to 41% among ages 18-34, while ages 55 and up reported 19%. In terms of demographic data, monthly podcast listeners were slightly more likely to be men. The group also reported slightly higher rates of full-time employment, of annual household income exceeding $75,000, and of college education compared with the general population.
Moving into more frequent listenership, 19% of respondents said they tune in to podcasts weekly. The mean time these dedicated fans spend with podcasts is 6 hours, 4 minutes, although the most common response, at 36%, was between one and three hours. The group also listens to an average of five shows per week. The weekly and monthly consumers were more likely to listen to shows from Canada's public radio producers, both at 47% compared with 42% for the "ever listened to a podcast" set.
Home is the most common spot for podcast listening, with 80% of monthly listeners ever doing so and 63% of them most frequently tuning in there.
The next slide, one of particular note for advertisers, asks how much of an episode monthly podcast consumers listen to. Just over half (53%) said they listen to the complete episode, while 35% said they listen to "most of the podcast." The options for "less than half" and "just the beginning" of shows each had single-digit percentages.
The report closed with statistics about smart speaker awareness and ownership. Monthly podcast listeners reported higher rates of awareness of both the Google Home and Amazon Alexa offerings, 67% and 66%, respectively, than the general Canadian population. The monthly listeners were also somewhat more likely to own smart speakers: 10% compared with the overall average of 8%.


Community Action Pioneer Valley seeks dynamic leader to oversee all aspects of the three-county Continuum of Care (COC) contract. The Director works with the COC Board, Committees, and over 25 COC member agencies to employ strategies for carrying out the goals of the COC and obtaining positive outcomes in addressing homelessness. This includes oversight of compliance, reporting, and budget of a national program and federal regulations. Ideal candidates will have a Bachelors' degree in Public Administration, Social Work, Public Policy or related field, 5 years of post-degree experience in human services/nonprofit sector, 5 years' experience in grant compliance and contract management, fiscal and program management related to human services; data collection and reporting, and administration or management experience with large collaborative projects.
Community Action is a well-respected, entrepreneurial, mission-driven organization with a high standard of excellence. The Director reports directly to the Director of Community Services. The main office is located in Greenfield, Massachusetts. Salary commensurate with education and experience. Salary range $60,000 – 65,000 plus excellent benefits. Please send cover letter and resume to caad331@communityaction.us.
Please send cover letter and resume to caad331@communityaction.us.


Pep Guardiola was caught playing the game of golf when Manchester United lost 1-0 to West Bromwich at Old Trafford to hand over the title to Manchester City.
Guardiola was seen to be playing the game of golf in order to pass time to see if Manchester United could delay or confirm their title triumph.
Manchester City won the league with 87 points with 5 games to spare and that will be Pep Guardiola's 24 trophy.


text:
Ngā Tāngata Taumata Rau
Last names beginning with D
Dawson, Joseph Bernard
Kōrero: Dawson, Joseph Bernard
Haurongo tūhonohono
Whārangi 1: Biography
Joseph Bernard Dawson
I tuhia tēnei haurongo e Brian Corkill,, ā, i tāngia tuatahitia ki Ngā Tāngata Taumata Rau Ko te wāhanga , 2000.
Joseph Bernard Dawson, the youngest child of Joseph Dawson, a commercial traveller, and his wife, Louisa Mary Collings, was born in Erdington, near Birmingham, England, on 8 April 1883. He attended King Edward VI Grammar School in Birmingham where he received a classical education. He then entered the University of Birmingham Medical School. Having come top in anatomy, Dawson spent a year as a prosector dissecting parts for teaching students. During this year he passed the primary for the FRCS before starting his clinical studies. In 1905 he qualified MRCS, LRCP and the following year MB, BS (London). For recreation he went cycling and distance running.
After graduating, Dawson became house surgeon at the Royal Alexandra Hospital for Sick Children, Brighton. Coming from a modest background, he had a long struggle to obtain good hospital posts and higher qualifications. He undertook general practitioner assistantships to finance the FRCS course at the London Hospital but failed the examination. He returned to Birmingham as resident surgical assistant at Queen's Hospital and house surgeon at the General Hospital, then gained a house surgeon's post at St Mark's Hospital in London. He gained the final FRCS qualification in 1908. Unable to find senior posts in London or Birmingham, Dawson bought a general practice in York. On 9 June 1909 he married Norah Lunt at Birmingham. He soon moved to Swansea and in 1911 obtained his University of London MD, in diseases of women. He also wrote two popular handbooks, The young mother and Babyhood .
With little hope of specialising in obstetrics and gynaecology in England, Dawson travelled to Australia as ship's surgeon. He bought a general practice in Glenelg, near Adelaide, and sent for his wife and family. He was able to build a practice with a special interest in obstetrics and gynaecology. During the First World War he spent a year in the Royal Army Medical Corps as a hospital surgeon in France. After the war he built his own private hospital. In 1925, before moving to Adelaide as a specialist, he visited Europe to study advances in antenatal care.
On his return to Australia Dawson was appointed honorary assistant gynaecologist to the Royal Adelaide Hospital. He later became tutor in obstetrics in the University of Adelaide, and was much involved in the development of ante- and postnatal clinics in the city. In 1931 he successfully applied for the first full-time clinical chair in obstetrics in the University of Otago Medical School, Dunedin. This had been established after increasing concern over the poor standard of obstetric training in New Zealand, and after substantial fund-raising by the New Zealand Obstetrical Society and its dynamic young secretary, Doris Gordon. Before taking up the post in February 1932, Dawson was asked to spend six months visiting clinics in Great Britain, Ireland, Europe and Canada.
Dawson was ill-prepared for the meagre facilities in Dunedin, made worse by the government reneging on building a promised hospital. However, he immediately commenced improving the standard of teaching, including personally supervising most of the deliveries conducted by the students. After long and acrimonious negotiations between the Otago Hospital Board and the minister of health, in mid 1934 government and local body funding was obtained for the 26-bed Queen Mary Maternity Hospital, formally opened in November 1937.
During Dawson's tenure he greatly improved the teaching of gynaecology and obstetrics; between 1932 and his retirement in 1950, maternal mortality was greatly reduced. Dawson lobbied hard for the establishment of proper obstetric and gynaecological units in the major hospitals in New Zealand staffed with properly trained specialists and with training positions for postgraduate residents. He became an active member of the committee which brought about the establishment of National Women's Hospital and the postgraduate chair of obstetrics and gynaecology at Auckland University College. Dawson was an examiner in obstetrics and gynaecology in medical schools in Australia, for the Royal Australasian College of Surgeons (he was made a fellow in 1934) and for the Royal College of Obstetricians and Gynaecologists in England. He was made a KBE in 1948.
Dawson was president of the Otago division of the New Zealand Branch of the British Medical Association, a member of the editorial committee of the New Zealand Medical Journal for many years, and chairman of the obstetrics research committee of the Medical Research Council of New Zealand. He was made a foundation fellow of the Royal College of Obstetricians and Gynaecologists at its inception in 1929, and from December 1932 headed its New Zealand committee and later its regional council.
Bernie Dawson became a greatly admired and respected teacher of obstetrics and gynaecology. A tall man, somewhat reserved but with a distinguished presence, he spoke with clear, precise diction. His political views were liberal and he was somewhat obstinate. He was interested in and supportive of his students and their activities, such as the University of Otago rugby football club, and was in his element recounting clinical problems or just talking from his wide fount of knowledge. He was a member of the Royal Commonwealth Society and president of its Otago branch for many years. After he retired from the chair he became a member of the Otago Hospital Board. He died in Dunedin on 17 August 1965, survived by his wife, two sons and two daughters.
Whai muri:Hononga, rauemi nō waho
Brian Corkill. 'Dawson, Joseph Bernard', Dictionary of New Zealand Biography, first published in 2000. Te Ara - the Encyclopedia of New Zealand, https://teara.govt.nz/mi/biographies/5d10/dawson-joseph-bernard (accessed 23 January 2020)


text:
Namdarpura is a village in the Bhopal district of Madhya Pradesh, India. It is located in the Berasia tehsil.

Demographics

According to the 2011 census of India, Namdarpura has 65 households. The effective literacy rate (i.e. the literacy rate of population excluding children aged 6 and below) is 73.09%.

References

Villages in Berasia tehsil


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Laboratory, Research & Development and Analytical Equipment Auction!
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Liquidation of Electronic Test and Ancillary Utility Equipment
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500+ Lots of Metrology, Machining, Injection Molding and Analytical Equipment from a Medical Device Manufacturer Site in CA
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December 12, 2019 9:00 AM ET


GameSpy online server browser for the retail version no longer works due to GameSpy services being shut down (the GOG.com and Steam versions have working multiplayer).
Blitzkrieg Anthology. No online play (only LAN).
The GOG.com and Steam versions have working multiplayer. GameSpy multiplayer services for the retail release have been shut down, and the Mac App Store version does not include any multiplayer.
If the game is running poorly change the Minimal FPS setting to 0.
16 For the GOG.com version use the installer available under bonus content.
↑ 2.0 2.1 File/folder structure within this directory reflects the path(s) listed for Windows and/or Steam game data (use Wine regedit to access Windows registry paths). Games with Steam Cloud support may store data in ~/.steam/steam/userdata/<user-id>/313480/ in addition to or instead of this directory. The app ID (313480) may differ in some cases. Treat backslashes as forward slashes. See the glossary page for details.


Managing your (modification) projects on time and within budget. Do you want support in the project scope definition? And do you have the right resources to manage your project safely and efficiently?
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We have even developed a proprietary tool for project management. World-class corporations benefit from Stork's PRINCE system, which offers integrated workflow and business process management for controlled execution of multi-disciplinary construction projects and modifications.


This is the general data protection regulation (GDPR) Page.
The Right of Access (Article 15 of GDPR) gives citizens the right to get access to their personal data and information about how these personal data are being processed. A Data Controller (That is us ie; the hysteriafm.com website owner) has to provide, upon request, an overview of the categories of data that are being processed (Article 15(1)(b)) as well as a copy of the actual data (Article 15(3)).
As the new GDPR regulations for EU countries suggests us (ie; the hysteriafm.com website owner) must provide, facilities for you the user, that allow you to request access to all/any the personal information collected by this website on you.


I was able to attend the Adobe Max Conference and the Russell Brown pre-conference where the theme was Kaijus. There were monsters created from the Stan Winston school and looked incredible. Not only did we receive the awesome monsters as reference, but we had awesome speakers like James White, Hydro74, Draplin, James Victore, and Rayce Bird.
During the conference I was able to produce a t-shirt and 2 posters.


Hello, I'd like more information about the listing I found on Homes.com at 708 Palmetto Boulevard.
This home is located at 708 Palmetto Boulevard Edisto Island, SC 29438 US and has been listed on Homes.com since 18 December 2018 and is currently priced at $1,295,000, approximately $415 per square foot. This property was built in 2007. 708 Palmetto Boulevard is within the school district(s) Colleton 01 School District with nearby schools including Edisto Beach Elementary School, Colleton County Middle School, and Colleton County High School. Similar properties nearby are 708 Palmetto Blvd, 702 Palmetto Blvd, 2604 Point St, 79 Lost Village Trl, 1406 Palmetto Blvd, 10 Toms Turnaround Cir, 614 Palmetto Blvd, and 216 Tranquility Ln.


Twitter and Facebook are growing and some people are feeling pressure or ambivalence about social networking. I'm schizo regarding my feelings about it all. It's fascinating, frustrating, handy and horrible all at the same time. It's also crack.
It will hurt less if you don't fight it.
It's been milked like Sugar Smacks too.
You're a writer by choice, tell them to bite you.


Popularity - 1,136 views, 4.4 views per day, 261 days on eBay. Super high amount of views. 8 sold, 30 available.
1,136 views, 4.4 views per day, 261 days on eBay. Super high amount of views. 8 sold, 30 available.
Seller - 34,638+ items sold. 1.9% negative feedback. Great seller with very good positive feedback and over 50 ratings.
34,638+ items sold. 1.9% negative feedback. Great seller with very good positive feedback and over 50 ratings.


I need a simple ad designed for you tube and perhaps a display ad too. I'll brief you and give you access to pictures as well. Not a lot of effort required, just putting ...just putting my ideas together. Skills required: Excellent creative and copywriting skills, video editing and photoshop. Budget - Looking for an excellent copywriter with high eq.
Looking f...prototype to look (The basis of the design should be of the design around the ear below). Using these examples we need a Custom Graphic Design made as well as 3D rendering of the product to be printed out. There will be two parts to the 3D rendering, a exterior/skeleton and the ear padding (using silicon) to fit together for the prototype.
I have been able to do this myself but the issue is I want the re...can use any language (or any method) as long the benchmark gives you around 15ms on average (if you can get 0ms god I'll give you a big bonus.) - You have to test in 60 hz. (most monitors are 60hz unless you are a gamer and bought one with a higher hz) - Only apply if you can do this.
Looking for an innovative, unique and really professional logo and design for a Medical Doctor. Its for an Ear Nose Throat Doctor/Specialist. Only highly skilled graphic designers wanted. I want to see your creativity...customers must be draw to this logo!
I am looking for a company which will create android app for car driving safety performance. APP to registe...performance. APP to register all physical parameters during the driving , speed, stops, fast breaks , GPS , times etc, generally similar to parental driving monitor app which monitors all aspects of car movement detected by smartphone sensors.
Need a professi...examples of what I look for. The model stock photo and some elements shown in mock-up will be provided, but designer will have to think creatively to improve the design of the banner. Designer might also need to do some Photoshop to remove the white background and the missing tip of ear and hair on the right side for the stock photo.


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Tag: manhattan
The Aspiration Index
Image source: https://newyorkyimby.com/2014/12/future-view-manhattan-skyline-2023.html
Skylines are a speculator's dream. Strictly speaking, they are not real things. In the same way that edges are not really there, but merely the points at which an object leaves a beholder's eye, a city's skyline is an imagined contour. If I ask you to imagine New York City's skyline, you will most likely picture a silhouette with the few telltale icons bristling among generic rectangles. Whenever Related Companies' CEO Jeff Blau promotes Hudson Yards on the news, he is sure to mention is the development's contribution to the skyline. The image can also change depending on where you live—whether you look east from Hoboken, north from Ellis Island, or west from the Long Island Expressway.
This imagined state is also what makes it a useful measuring tool. Since it is capable of accommodating many different viewpoints, and since it changes constantly in response to citymakers' speculations, a skyline is what I like to call the Aspiration Index of a city. It is a summation of all of the city's past and future ambitions, an agglomeration of jostling voices into a coherent whole.
So the question arises: who controls the fluxes of this Aspiration Index? Who are the big influencers in that market? In the case of New York City, the answer has been clear for over a century: wealthy players in real estate. Since the skyscraper boom at the end of the 19th century, it has always been up to the oil tycoons and media magnates to determine the shape and color of the city canopy. Ironically, those players rarely leave the city themselves, and the skyline they mold is viewed predominantly by the working classes who live on the outskirts. This contrast is especially striking at night, when the city's tallest buildings illuminate the dark with an array of colors.
NYC skyline , 1904s. Image via http://www.oldstratforduponavon.com/nyc4.html
The Empire State Building, a mainstay of the New York City skyline for almost 90 years now, has been outfitted with colorful lights on its crown since the 1960s; and since a lighting upgrade in 1976 has started the tradition of being lit up in different colors every night in reference to holidays or other city-wide events. It has become a pastime for some to look up at the lights after dark and guess what the day's reference is. Over the years, it has expanded into a reservation system, in which various non-profits can apply to choose a commemorative lighting display for a single night. The spire on One Bryant Park even has its own Twitter feed which advertises the commemorations. However, these commemorations only occur once every several days, meaning that for most days the city lights remain firmly in the hands of the property owners, The Durst Organization.
Perhaps it was this detail of the empty, uncommemorated days which gave Mark Domino, son-in-law of The Durst Organization's Chairman, an idea. He developed an app called Spireworks which allows users to log in and, for a few minutes, control the lights of One Bryant Park in real time. The app was distributed to several thousand users as a test, and it quickly exploded in popularity as users jostled for their chance to send secret messages, impress friends, and seduce dates. For the first time, a landowner had to give up control, and the inhabitants of New York seized the chance to make the skyline theirs. Mark Domino told Metro News in 2017 about his own aspiration to "transform Spireworks into something that has a greater social benefit."
Admirable as it is, however, it is difficult to imagine what Mark Domino means exactly by "greater social benefit," beyond reverting One Bryant Park's spire to an organized, regulated reservation system like the Empire State Building. Meanwhile, since new technology evolves at a pace all its own, Spireworks has taken on a reputation of white-collar exclusivity quite contrary to its original intent. This is partially determined by design: digital queues have maximum wait times so as not to eat up bandwidth, and in order to gain access to the app, you have to be invited by an existing user. Spireworks now gives access to the lights of Four Times Square (also a Durst Organization property) and Domino has stated plans to expand, but that front has quieted.
Less than two years ago I visited my friend in Brooklyn Heights. She took me out on her balcony which faces the Brooklyn Bridge and Lower Manhattan, and said, "Watch this." She pulled out her phone and began pressing buttons, and in the distance, I watched open-mouthed as the crystal spire changed color within seconds. She sent me the invitation the next morning, but I never touched it. Like the hijacked innocence of the app itself, I never thought of it as more than an exclusive toy. I remembered that day on the balcony when I began putting this piece together, and I called my friend to get a live image. I logged into Spireworks in Barcelona and we opened a Skype call. For five minutes we fidgeted with camera angles and headphones and session timeouts, never quite getting the results we wanted. Maybe there was a concurrent user showing off in Midtown. Maybe the app just doesn't work from Europe. But there I sat anyway, 3,800 miles away from my hometown, fighting for my momentary lease on the New York City skyline.
Author the.vonz.himanenPosted on April 30, 2018 September 9, 2018 Categories Non-fiction, urbanismTags durst organization, empire state building, index, manhattan, new york city, one bryant park, skyline, spireworksLeave a comment on The Aspiration Index


I recorded this story for WUWM's Lake Effect and it aired on 10/17/12. Given the election season, it felt right to dust it off and post it.
Awesome experience for you I bet! Thanks for getting back in the groove of making us laugh.


A good digestion is very important to have iron health. After a full meal, I naturally feel sleepy. Many people feel the need to take time in different ways, and some habits can lead to serious health problems. Doctors recommend that you avoid some activities right after you eat, Here are the things we shouldn't do after having a meal.
Fruits are good for your health, many doctors recommended. But dieticians suggested that it can be harmful after a meal, you need to wait for 20 minutes.
Many people choose to shower just after having a meal. When you shower, the body temperature changes and the body tend to send a larger amount of blood to the tissues. This hinders digestion and can cause problems in the metabolism. Moreover, If you go to the sea or the pool, avoid swimming right after you've eaten. It would be better to give the body a 30-minute respite, and only then do these activities.
Tea is not a good choice right after the meal. tea affect iron levels in your body, which can cause health problems. Instead, you can consume a cup of coffee or a glass of water, but not immediately after you have finished eating.
People have a habit of sleeping just after they finish their dinner or lunch, believing that this helps the food digest better. This custom favors the accumulation of extra pounds, causing stomach burns and increased acidity. Experts recommend rest after 2 hours after the last meal.
Physical exercise immediately after the meal can do more harm than good. There may be digestive problems, nausea, and a total discomfort. However, an easy ride is recommended, and exercise only 2 hours after a meal.
Smoking after the meal causes nicotine to be absorbed in the double amount in the body, also causes a brief rise in metabolism, with the most harmful effects. Furthermore, it prevents the absorption of vitamins and minerals in the body. If you want to smoke, wait for 20 minutes from the time you have finished eating.


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The enforced disappearances in Balochistan has to be worrisome for the world: BSO Azad
Current Balochistan
The Central Spokesperson Baloch Students Organization Azad (BSO-A) said on the occasion of the International Day of the Victims of Enforced Disappearances that the issue of missing person in Balochistan is being more and more serious; and the incidents of enforced disappearances are continuously being reported; among the victims political activists, students, human rights activists, lawyers and the journalists are included.
"While talking about the International Day of the Victims of Enforced Disappearances, the spokesperson said that the enforced disappearance is a crime in accordance to the International Law. Against this crime, the General Assembly of United Nations had approved a law on 20th December 2006, and this law gives the relatives of the victim the right to know the reality about the disappearance of their beloved ones, and the right to search and trace them".
BSO-A statement further read that An arrest, custody or abduction, or, to deprive a person of freedom which is snatched directly by the agencies or the army of the state, and when no one has any information about that person, and if the victim is out of the jurisdiction of law, then such an act is called as enforced disappearance.
"Whether there are circumstances of war or fear of occurrence of war, internal political instability or an enforcement of emergency; none of these circumstances can justify the use of enforced disappearances," according to the convention.
"The convention says to the state that it has to give information to the family or the lawyer of the missing person about the location of the detention center, timing of detention and about the authority that has made this detention; and if the victim dies during the custody, then the relatives or the lawyer of that victim should be informed about the causes and conditions of death and about the location of the dead body".
In according to this convention, the state of Pakistan and its agencies, since the beginning, in Balochistan, has illegally disappeared and tortured the political activists, students, teachers, journalists, lawyers, intellectuals and the human rights activists including the people from all schools of thought; while several of them have been killed in the state detention centers and their dead bodies have been trashed.
"The state is trying to enforce complete ban over the political consciousness and awareness in Baloch society. Those people who have political consciousness and knowledge are considered the backbone of Baloch nation; and the state has used every possible mean to weaken it" the spokesperson added.
"In the end, the spokesperson said that the worst situation of human rights in Balochistan has to be worrisome for the world; because the effects of this crisis can cause danger for the future of this region and the nations of world".
"The international institutions should bound the state of Pakistan to this global convention and make it declare enforced disappearance as a serious crime in accordance to this convention and establish strict punishment for the elements involved in it. It is difficult to stop enforced disappearances despite such measures".
http://cubalochistan.home.blog/2019/08/30/the-enforced-disappearances-in-balochistan-has-to-be-worrisome-for-the-world-bso-azad/
The enforced disappearances in Balochistan has to ...


Standard Service Includes: Delivery and installation of your purchased automatic pool cleaner. We will completely install and test for proper operation your new pool cleaner. Installations vary depending on the style of pool cleaner purchased. There are three typical pool cleaner styles (Pressure-Side, Suction-Side, and Robotic). Pressure side cleaners typically use a booster pump. A suction side cleaner typically connects to your skimmer or any other in pool suction line. A robotic cleaner operates as a standalone cleaner not requiring hookup to any of the poll water lines.
A pressure side cleaner usually operates using a "booster" pump system that works in conjunction with your primary pool pump.
A suction side cleaner hooks into your pool skimmer or an in-pool return line that is already plumbed and being used as a suction line.


The ME1304 is a water cooled, totally enclosed IP65 motor. Designed for 24 to 96 volt battery operated systems. It is an Axial Air Gap, Permanent Magnet Synchronous Motor. Weight of 36 pounds. There is a Sine/Cosine rotor position sensor, and a KTY84-130 Temperature Sensor in the motor windings. Motor weight of 44 pounds.
Designed for 180 amps continuous, 450 amps for 2 minutes. Maximum rotor speed of 5000 rpm. Recommended 6 liters per minute water cooling. Can also be used as an Air Cooled, Totally Enclosed motor without water cooling, but de-rated to 125 amps continuous.
Rating of 14.5 kw continuous with a 96 VDC battery pack voltage.


For the Love of Volunteers! How Do You Choose the Right Technology to Help Manage Them?
What makes a good volunteer management system, and what are the needs you should consider? How do you evaluate off-the-shelf products, and what questions do you need to ask to make sure they'll work for you? What if you have volunteers managing other volunteers? How do you know if you need a custom solution? We'll talk about some great off-the-shelf products and in what situations they work best (because why take on technical debt if you don't need to?), and then we'll dive into a custom solution case study.
Custom Solution Case Study: After reviewing their options, Washington Trails Association determined their needs were too complex for an off-the-shelf system, and so they built a custom platform that integrates with both their website and their CRM. Their old volunteer platform had served them for 15 years (or one million years in technological terms) and their volunteers were accustomed to how it functioned. WTA's big challenge was to build a new platform that their volunteers would like (and hopefully love) and that would better integrate with their other tools and provide better efficiency for a stretched staff.
This session is a great one for organizations rethinking their volunteer management platforms and will give audience members an idea of what's possible (either off-the-shelf or custom-developed), the range of staff and financial investment required, and payoff in terms of staff efficiency, volunteer happiness, and program impact.


text:
Corporate/Commercial Law
Canada: British Columbia Supreme Court Rejects Plan Of Arrangement For Barring Claims Of Historical Shareholders
by Sana Ebrahimi
Siskinds LLP
In Re iAnthus Capital Holdings, Inc., 2020 BCSC 1442, Justice Gomery of the BCSC rejected a plan of arrangement due to the overly broad scope of release and injunction clauses which were found to bar claims of historical shareholders which preceded the plan. His Honour did not dismiss the petition, but rather provided iAnthus and its noteholders with an opportunity to amend the plan to "narrow the release and injunction to the point of acceptability".1
iAnthus Capital Holdings, Inc. ("iAnthus") develops, owns, and operates licensed cannabis cultivation, processing, and dispensary facilities in the United States. iAnthus is incorporated pursuant to British Columbia's Business Corporations Act (the "BCA"), and its shares trade on the Canadian Securities Exchange.
In April 2020, iAnthus defaulted on multiple debt obligations to both secured and unsecured debenture holders. On July 10, 2020, after negotiations, iAnthus, all secured noteholders, and holders of 91% of the indebtedness under the unsecured notes entered into a Restructuring Support Agreement ("RSA").
The RSA contemplated a restructuring of iAnthus by way of a plan of arrangement, requiring court approval pursuant to s. 291 of the BCA. The terms of the RSA provided the noteholders would release iAnthus of its debt obligations (US$33 million to secured noteholders and US$45 million to unsecured noteholders) in exchange for 97.25% of the outstanding common shares of the company. Accordingly, the interest of iAnthus' present holders of common shares would be reduced to the remaining 2.75% in the equity. The noteholders unanimously approved the arrangement.
iAnthus petitioned the court seeking to obtain the required approval of the arrangement. The order sought by iAnthus included a permanent injunction enjoining "all persons" from advancing any of the released claims.2
Justice Gomery declined to approve the plan of arrangement, citing specific concern with the broad scope of its release and injunction clauses as they pertained to the rights of historic shareholders.
Justice Gomery began his analysis by noting that the court's power to approve an arrangement is conferred by s. 291 of the BCA. His Honour noted the legal framework governing the exercise of the court's power under s. 291 was settled in BCE Inc. v. 1976 Debentureholders, 2008 SCC 69 ("BCE"), and requires the court explore the following questions:
Have the statutory requirements been met?
Is the arrangement made in good faith?
Is the arrangement fair and reasonable?
Justice Gomery concluded that he was satisfied that all abovementioned questions would be answered in the affirmative, but for the broad scope of release and injunction clauses.
The Release Clause
The release clause in the plan of arrangement, as drafted, released the following parties:
"iAnthus Released Parties" defined in as: iAnthus and each of their respective current and former officers, directors, employees, current and former shareholders, auditors, financial advisors, legal counsel, and agents; and
"Securityholders' Released Parties" defined as: noteholders and persons associated with them.3
Justice Gomery noted the beneficiaries of the release included persons who provided advice to iAnthus at arms' length years ago, former officers and directors, and former shareholders who may have held shares and sold them years ago. Moreover, the release as drafted barred claims "arising on or prior to the Effective Date ... for a monetary loss resulting from the ownership, purchase or sale of an equity interest in iAnthus".4
Justice Gomery held the release was too broad and as such it was legally unjustifiable for him to make it an "ancillary order" under the BCA (discussed below) as it would bar claims of historical shareholders that preceded the plan of arrangement.5 His Honour rejected iAnthus' justification that the alternative to the plan of arrangement would be a Companies' Creditors Arrangement Act ("CCAA") filing under which neither present nor former shareholders would receive anything from the company.6
Justice Gomery took issue with the release pertaining to third parties. His Honour rejected iAnthus' reliance on Concordia International Corp. (Re), 2018 ONSC 4165 ("Concordia") where, in the context of an arrangement proposed pursuant to s. 192 of the CBCA, the court applied principles developed under the CCAA in deciding that third party releases were appropriate.
In rejecting the applicability of Concordia to the case at hand, Justice Gomery stressed the difference between the CCAA and the arrangement procedure under the BCA. Specifically, His Honour noted the BCA is "not as open-ended as the CCAA".7 While the CCAA expressly allows all creditors to have a say with respect to adopting a proposed arrangement, third party releases under the BCA restrict the rights of persons who have not been given an opportunity to have their say.8 His Honour concluded: third parties do not get a vote under the BCA. Consistently, in the case at hand, the RSA negotiation involved only iAnthus and its noteholders. Third parties were not at the table.
Justice Gomery noted authorization of a plan of arrangement involving third party releases can only be pursuant to the court's power under s. 291 (4)(c). The section states:
(4) [...] on an application to court for approval of the arrangement,
(c) the court may make any incidental, consequential and supplemental orders necessary to ensure that the arrangement is fully and effectively carried out.9
Justice Gomery referred to the British Columbia Court of Appeal's decision in Protiva Biotherapeutics Inc. v. Inex Pharmaceuticals Co., 2007 BCCA 161 ("Protiva"), in which a plan of arrangement involving third party rights was approved. In Protiva, the BCCA held:
Third party rights must be considered and accommodated within the discretionary analysis but they cannot be erected as an impermeable barrier to an arrangement. Were it otherwise, the third party could exercise powerful leverage wholly out of proportion to the value of the rights compromised by the arrangement, or the party could simply act as a spoiler for purposes unrelated to those rights.10
Justice Gomery explained that while the BCCA in Protiva approved the plan of arrangement involving third party rights, it did so only after being satisfied that the objecting creditor would not suffer prejudice. The BCCA made it clear that the court's power to make "incidental, consequential and supplemental orders," could only be justified where any interference with the rights of third parties to the arrangement is "truly ancillary and the substantive positions of third parties are protected".11
In the case at hand, Justice Gomery found that the release sought could not be justified as a "fair and reasonable balancing of the interests of the historical shareholders" who would receive no benefit under the plan and may not even be aware of the current proceeding.12
The Injunction Clause
Next, Justice Gomery took issue with the permanent injunction clause in the plan of arrangement which would bar "all persons" in the following terms:
All Persons are permanently and forever barred, estopped, stayed and enjoined, on and after the Effective Date, with respect to any and all Released Claims, from (a) commencing, conducting or continuing in any manner, directly or indirectly, any action, suits, demands or other proceedings of any nature or kind whatsoever against the Released Parties, as applicable; (b) enforcing, levying, attaching, collecting or otherwise recovering or enforcing by any manner or means, directly or indirectly, any judgment, award, decree or order against the Released Parties; (c) creating, perfecting, asserting or otherwise enforcing, directly or indirectly, any lien or encumbrance of any kind against the Released Parties or their property; or (d) taking any actions to interfere with the implementation or consummation of this Plan; provided, however, that the foregoing shall not apply to the enforcement of any obligations under this Plan.13
iAnthus submitted the purpose of the injunction clause was to encourage early resolution of any issues concerning the availability of the release. Justice Gomery rejected this submission and found not only would the effects of the injunction go beyond encouraging early resolution, but that it would in fact convert any unsuccessful attempt to challenge the release into a contempt of this Court.14
Justice Gomery held the injunction, much like the release clause, would bind historical shareholders, who may not have had notice of this proceeding. His Honour went further and stated that even if the release clause was modified to the point of acceptability, he would not approve the plan of arrangement on the basis of the injunction clause as presently formulated.15
Following the release of Justice Gomery's decision, the petitioners narrowed scope of release and eliminated the injunction clause in a revised plan of arrangement. The revised plan of arrangement was approved by Justice Gomery a month later, in iAnthus Capital Holdings, Inc. (Re) 2020 BCSC 1484.
1. Re iAnthus Capital Holdings, Inc., 2020 BCSC 1442 at para 99.
2. Re iAnthus Capital Holdings, Inc., 2020 BCSC 1442 at para 8.
8. Re iAnthus Capital Holdings, Inc., 2020 BCSC 1442 at paras 69 and 73.
10. Re iAnthus Capital Holdings, Inc., 2020 BCSC 1442 at para 66.
15. Re iAnthus Capital Holdings, Inc., 2020 BCSC 1442 at paras 97 and 98.
Sana Ebrahimi
Canada Corporate/Commercial Law Corporate and Company Law Shareholders
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So, what keeps kids from following directions?
First, we assume they heard us in the first place. More so, we also wrongly assume our kids registered the information, processed it, absorbed it, agreed to comply with it, and are now about to take action.
When we say, "Unpack your lunch box" and our kids reply, "Yes m'am" (I'm a southerner — we work hard on that one!), we somehow believe our kids are right there with us, eager to please. But, that's not what's really happening.
Your son's thinking about the video game he's been waiting all day to play, or your daughter's chomping at the bit to jump on group chat with her friends. Or, maybe she's thinking about a snack and he's thinking about getting his homework done.
Whatever it is, your kids dutifully respond to you because they've learned to do so automatically. But more than likely, they never processed what you actually asked. In one ear and out the other, with a "Yes m'am" in between for good manners.
And, be honest, you do the exact same thing to your kids!
Think about it. How often do you reply to your children (or anyone, really) automatically, only to shake your head a moment later and say, "Wait a minute, can you say that again?" As adults, we feel confident asking someone to repeat something because we feel responsible to make sure we're fulfilling our obligations.
But kids? Well, they may feel responsible, but there are SO many obligations, and sometimes, they're too occupied to make sure they have all the bases covered. Besides, if it's really important, you're going to remind them again, anyway, right?
Here's a truth for you, parents — kids and teenagers are the most distracted people on Earth.
And that goes for ALL of them, especially in this digital age of distraction. It's part of their wiring. Their brains are a work in progress. Your kids' minds are working overtime on matters that have nothing to do with the direction you just gave (thus why it quickly slid right out of her head).
Unfortunately, what we do (as parents) in those moments is wrongly assume our kids just don't respect us. But, that's NOT true.
For most kids under the age of 13, there is at least a part of them motivated to please you. They want to do well, feel successful and make you or their teacher proud. So 9 times out of 10, they really did forget to unpack their lunchbox — not because they're trying to tick you off and be disrespectful.
Now, if your child is 14 or older, the need to please begins to take a back seat to their need to self-express — and that's actually a good thing. Instead of battling with them over wet towels on the floor (which you've told them to pick up for the umpteenth time), it's time to help your kids find their OWN motivation for hanging up the towels. That's the ticket to independence — and ultimately to freedom, yours and theirs!
So, start asking yourself, "What's in it for him (or her)?" And if you can't come up with anything, that's a clue as to why the task is not getting done.
So how DO you get your kid to listen and follow your directions?
1. Don't take it personally. It's reasonable to expect that kids won't follow all of your directions the first time, every time. This is a family, not an army barracks.
2. Get your kids' attention before you give them a direction. Touch their shoulder, call their name, or look them in the eye.
4. Ask for acknowledgment that they've processed the request. Ask them to confirm more specifically: "Yes m'am, I'll take out the trash before dinner."
5. Help them find THEIR motivation. The best question parents can ask themselves is: "What's in it for my child?" Understanding your child's world through that perspective is a magic ticket for parents.
As parents, we tend to make REALLY BIG assumptions that actually get in the way of helping our kids learn to follow our directions. The truth is — when our kids don't follow directions, it's not really the next act in an ongoing disrespectful tragedy. It's really more of a comedy — part human nature colliding with part human brain.
When you can accept that, and roll with it — the positive results will surprise you. No more sounding like a broken record!
Elaine Taylor-Klaus and Diane Dempster, founders of ImpactADHD.com, teach/write about practical strategies to parents of "complex" kids with ADHD and related challenges. To help your kids find the motivation to get anything done, download their free parent's guide, The Parent's Guide to Motivating Your Complex Child.