God has created each and every one of us as unique individuals. It is incredible to see the many differences between all of us. When we look at the body of Christ, we see people of every nationality, gender, and age all coming together to further the Gospel of Christ. Somehow, in the midst of all this diversity, Christ brings us together to do His work on this earth. However, due to our sinful nature there are many times where the unity we are called to have can break down. We see people more focused on their own desires, instead of sacrificing for one another.
Paul understands this battle for unity that believers face, and he addresses it in Philippians 2:1-5. He encourages believers to be of the same mind, maintain the same love, be united in spirit and intent on one purpose. As believers, our one purpose needs to be proclaiming the Gospel of Christ. We have been given the Great Commission, and it is when we stray from that purpose that we see our unity break down. As a church we can have unity in our diversity when we are all pressing forward with the Gospel as our main goal. There are thousands of people in the towns we live in that need to hear the Gospel, and it is our mission to be unified as a body of believers preaching it to them.
Also, in our unity, we need to be putting others before ourselves. Verses 3-5 instruct us to adopt the same attitude that Christ has. He came to this earth, humbled himself, and died on a cross for the sins of humanity. He paid the ultimate price for the good of others. This is an attitude that may seem impossible for us to have, but through the power of the Holy Spirit we can emulate Christ. To have true unity we must forget our own desires and focus on the needs of the body of Christ. This extends past the body of Christ to the world. We need to be showing the love of Chist to other people by meeting their needs instead of our own. We honor God by serving "the least of these" in our every day life. Thought we all may be different, let's honor God through our unity by laying down our desires and meeting the needs of each other.
Discussion Question – Why is unity within the church so important?
In Acts 16:11-34, we see the birth of the church in Philippi. Paul arrives in Philippi on his missionary journey and finds Lydia, the slave girl, and the Jailer. These three radically different people end up becoming the first pieces of an incredible movement of God in Philippi. It goes without saying that these three people may have not been an "ideal" church planting team. You have a prominent businesswoman working along side a girl who just had a demon cast out of her. Then, you have those two working along side a blue-collar tough guy who almost killed himself before converting. This is not what I would consider the dream team, but these are the people God uses through Paul to spearhead the diverse beginning of the Philippian church.
We see such a beautiful picture of what the Gospel and church are all about through Lydia, the slave girl, and the jailer. Paul understood that there was nothing that could stop the Gospel from impacting the lives of these people. The socioeconomic, religious, and racial walls that people build up between themselves crumble when the Gospel is introduced. The blood of Jesus Christ is the single unifying factor we have in this world. We can celebrate our differences in the way Christ made us; all while knowing that through Christ we are one family. Once these three people were saved by the grace of Christ they all joined the body of Christ together. They were just the beginning of a radically diverse church in Philippi that would be unified under Christ.
We need to understand the serious implications the Gospel has on our lives and on our church. It should breakdown any barriers that exist between us and any other person because the love of Christ is more important than any difference two people can have. The church in Philippi had a diverse beginning that led to a diverse church, all because of the power of the Gospel. It has the power to save any who would open their ears to hear it. It saved a wealthy businesswoman, a possessed slave girl, and a suicidal blue-collar jailer. God then used these people to spread his Gospel to an entire city. Let's see the Gospel go forth in the same mold as it did with the Philippian church.
Discussion Question – Why do you think God used such an eclectic group as the start of the Philippian church? How can we apply that to our own life?
The jailer was terrified when the earthquake happened, the doors of the jail were thrown open and the prisoners' "…bonds were unfastened." For him this was inevitable death. The prisoners would run, he would be blamed and executed. In his mind the only option was to end his life on his terms…until he heard Paul's voice. Paul's voice broke through the darkness. In that moment the jailer realized that all of the prisoners were still there, and his life would be spared. Imagine what that moment must have felt like for the jailer, a mix of surprise, awe, and God opening his heart to Him. It was life changing; he instantly knew his need for God, and knew that the men who had spent the night praising and praying to their God must have the answers.
God was pursuing the jailer, getting his attention. While we have the whole perspective, the jailer could have chalked up the prisoners staying as a lucky break, or just accepted it and continued his life the way he had been living it. How many times and situations has God tried to get your attention? You cried out to Him for help, and you ignored the help He offered, or thought it was your own doing? The jailer was able to recognize the work of God and it changed his life.
Discussion Question – Talk about a situation in which you ignored God's prompting and relied on your own strength. How could you have handled it differently?
Paul was continuing his journey in Philippi, and he was joined by Silas. As they were out in the streets proclaiming the Gospel, they crossed paths with a slave girl who was possessed. She followed them for days disrupting them, to the point that the Bible says that Paul, "having become greatly annoyed" addressed the girl (or rather the spirit that had possessed her). It was clear to Paul that the slave girl was possessed, being able to tell fortunes, and her owners were using her for economic gain.
When Paul commanded the spirit to come out of the slave girl, he had to have known that her owners would be enraged, since their ability to use her for money would be gone instantly. Paul and Silas did it anyway, and they were instantly taken into custody. So, what can we learn from this short story leading into the imprisonment of Paul and Silas? We are to obey God no matter what? Absolutely! Protect those less fortunate than us? Of course!
What stands out the most to me is that we all have that one person who drives us crazy. God has called us to help them, guide them, even disciple them, and yet they annoy you. Why would God bring those people into our lives? Insist on reaching out to them? Simply, He has something to teach us, and situations that He decides to use us. God used the slave girl to get Paul and Silas in a situation where they could help the jailer (see tomorrow).
Those situations guide us into moments that change our lives, and allow us to see God work in miraculous ways. If we decide to avoid the uncomfortable situations, we miss seeing God work and being used to further His Kingdom. Embrace people God brings into your lives, no matter how annoying or exhausting and ask God to use you for His glory.
Discussion Question – What are some situations/people that you avoided because it was too uncomfortable or too difficult to handle?
Paul and Timothy were on a journey, one that was difficult and emotionally draining. God was leading them on their journey, but when they attempted to go Bithynia God prevented them from going there. After they were prevented from moving in that direction, Paul saw a vision directing them to go to Macedonia, "concluding that God had called us to preach the gospel to them." They ended up in Philippi, and after a few days, on the Sabbath, they set out to find a group of believers. Lydia, from the city of Thyatira, was in the right place at the right time. Lydia was amongst the women that Paul and Timothy stopped to talk to about the Gospel. The Lord opened Lydia's heart, and she gave her life to God. She then converted her entire family. After all of that, she invited Paul and Timothy into her home and gave them a place of rest and recharge.
What does that mean to us? Lydia was included in Acts, in the Bible, for a reason. There is something we can learn in this small story in Acts. Lydia was a "worshiper of God" and yet not a follower of God. She was searching, seeking out follower's of God, and gathering with them on the Sabbath. It says in verse 14, "the Lord opened her heart to pay attention to what was said by Paul." God enabled Lydia to get past all of her worries, all of her reservations, and see what He was offering. It's almost comforting it doesn't indicate what Paul said that day to her, but that God opened her heart, not Paul, not Timothy, but God. It reminds me that we are called to proclaim the Gospel. We don't have the power to save people. We are simply called to proclaim. In all of my inabilities, stumbling words and nerves, God somehow uses those moments to speak into people's lives. Don't let our inabilities or fear stop us from telling people about the Gospel, because God is there in those moments, and He is working.
Philippi held a special place in Paul's heart. In Philippians 1:4, he even talks about the partnership in the Gospel he feels with the church. Lydia is a great example of the hospitality and support the church of Philippi gave Paul. He had a community that supported him, loved him, and prayed for him. This gave Paul strength through his ministry and imprisonment (Philippians 1:7). We all need community, support, love and truth in love. We were created to crave this, to be surrounded by this, and this allows us to go out into the world and make disciples.
Discussion Question – How can you overcome your fear and hesitation in sharing the Gospel?


"Both reports' authors call for an overhaul of the nation's immigration laws, including establishing a legalization program for some of the estimated 11 million people who are in the United States unlawfully."
Go back home and dont call us, we'll call you. If we need you here in the US. Otherwise: STAY HOME!


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GSA steht für:
 Citroën GS, Pkw-Modell von Citroën, ab 1979 als Baureihe GSA
 Gambia Swimming Association, gambischer Schwimmverband
 Gefahrstoffschnellauskunft, Gefahrstoffdatenbank für Einsatzkräfte
 Geld Service Austria, wickelt den materiellen Bargeldverkehr der Österreichischen Nationalbank mit den Filialen der Banken ab
 General Services Administration, unabhängige Agentur der US-Regierung für amerikanische Bundesbehörden
 Genetics Society of America, US-amerikanische Fachgesellschaft von Genetikern
 Geological Society of America, US-amerikanische Organisation zur Förderung der Geowissenschaften
 GeoSphere Austria, österreichische Bundesanstalt für Geologie, Geophysik, Klimatologie und Meteorologie
 Gerchberg-Saxton-Algorithm
 Germany, Switzerland, Austria, der deutschsprachige Sprach- und Wirtschaftsraum, siehe D-A-CH
 German Snowboard Association, siehe Snowboard Verband Deutschland
 German Studies Association, eine kulturwissenschaftliche Vereinigung
 Global Semiconductor Alliance, hervorgegangen aus der Fabless Semiconductor Association
 Grenzschutzabteilung des aufgelösten Bundesgrenzschutzes, siehe Bundesgrenzschutz #Organisation
 European GNSS Agency, siehe Agentur für das Europäische GNSS
 Gustav-Siewerth-Akademie, private Hochschule in Baden-Württemberg
 Long Pasia Airport (IATA-Code), Flughafen von Long Pasia, Sipitang, Sabah, Malaysia

Abkürzung

redpajama_set_name: RedPajamaWikipedia


the only cookie compendium you'll ever need!
New hardcover book, 360 pages including very comprehensive index and over 200 colour photos.
A cookie compendium, filled with 500 failsafe, melt-in-the-mouth recipes. Crammed with advice on ingredients, basic techniques, conversions and even troubleshooting tips for when things go wrong. A beautifully illustrated and easy-to-follow guide to creating perfect cookies every time - golden brown, crisp on the outside, sublimely moist on the inside. Jam-packed with delicious cookie recipes, all of them clear and easy to follow, including traditional favourites from around the world.
Includes a comprehensive introductory section on cookie basics: techniques, equipment, ingredients, cookie types and even troubleshooting tips.
A true cookie compendium, from creamy French macaroons to lemon fingers to triple chocolate cookies.
After gaining her formal catering training, Philippa Vanstone spent 10 years working in London restaurants and hotels. She then began working as a development chef - travelling to New York, Boston, Chicago, New Orleans, San Francisco and Atlanta, researching bakery products for the UK retail market. Philippa has also lectured at universities in England on Patisserie and Confectionary, and now works as a freelance cookery writer and food stylist, specialising in all things sweet!


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Aphaniosoma scutellaris är en tvåvingeart som beskrevs av Ebejer 1998. Aphaniosoma scutellaris ingår i släktet Aphaniosoma och familjen gulflugor. Inga underarter finns listade i Catalogue of Life.

Källor

Gulflugor
scutellaris


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Home » Drafting-Particulars of Claim
Drafting-Particulars of Claim
IN THE WEST LONDON COUNTY COURT Claim No
BIANCA BOUNTY Claimant
(1) DAMIAN HOWARD
(2) REG.HOWARD & SONS (a firm) Defendants
PARTICULARS OF CLAIM
The Claimant is the owner of both a washing machine and Cartier watch. The first Defendant is a washing machine repairman and is a partner in the second Defendants firm of plumbers, fitters and electricians who held themselves out as skilled, experienced and competent to carry out the repairs and service from their offices at 82 Battle Street, Vauxhall, London SW2.
By an oral agreement made at the Claimant's flat 6A Caernarvon Mews, London W2 on Sunday 22nd June 2003 between the Claimant and the first Defendant, it was agreed that the first Defendant would fix her broken washing machine in return for a ticket to the Fashion and Glamour Awards in September, which was worth £100 face value. The first Defendant on his own behalf or on behalf of the Second Defendants agreed to do so.
The first Defendant knew at the time of the agreement that the Claimant would rely on his repair and servicing of the washing machine to wash her clothes.
It was an implied term of the agreement that the first Defendant would repair and service the Claimant's washing machine with all reasonable care and skill to be expected of an experienced, skilled and competent repairman. Further or alternatively the Defendants owed the Claimant a duty to exercise such care and skill.
The first Defendant in performance of the contract repaired the washing machine on 22nd June 2003 assuring the Claimant that the machine works fine, and explained to the Claimant the cause of the fault, namely an Intel valve was stuck, which prevented the machine filling up with water.
At about 9.p.m on 22nd June 2003, the Claimant before going to sleep filled the machine up and set it going. The next morning at about 6.a.m when the Claimant woke up, the whole flat was flooded with water, all the carpets were wet, and there were puddles of water in places. As water was still running into and out of the washing machine, the Claimant turned it off.
In repairing the machine and servicing, referred to above, the Defendants were in breach of the implied term of the agreement and /or the first Defendant was negligent in that:
PARTICULARS OF NEGLIGENT
(a) He sabotaged the washing machine.
(b) He failed to identify the actual cause of the fault.
(c) He failed to measure the consequences of bad workmanship.
(d) He failed to take any or adequate precautions to avoid damage in repairing washing machine.
(e) He failed to check the machine's performance with reasonable time after being repaired.
(f) He failed to disclose the Claimant his experience and skills of repairing the washing machine.
(g) He assured the Claimant that the machine was working fine when he ought to have known that the machine would or would likely to break down.
(h) He failed in all the circumstances to exercise the care and skill expected of a competent repairman.
8. As a result of the matters set out above of the Claimant has suffered loss and damage.
PARTICULARS OF DAMAGE
(1) Lost of assignment fee due to the missing flight 10,000.
(2) Cost of new washing machine 350
(3) Cost of pulling up all carpets for drying and then relaying them 587.50
(4) Value of books and tapes ruined 95
(5) Cost for Bertie's new ceiling plaster and decorations 1,116.25
(6) Cost for investigating the damage to the washing machine 64.62
(7) Earning of two weeks instead of going Bahamas 750-
9. Furthermore, the first Defendant has wrongfully taken possession, defined as a act of conversion, of the Claimant's Cartier watch from her jewellery case when he was in her flat, on a date unknown to the Claimant, but between 21st June and 22nd June 2003. The first Defendant however has at all times since that date to return to the Claimant the Cartier watch, but failed to do so.
10. The Claimant has suffered loss due to the first Defendant's wrongful possession of the Cartier watch. Moreover, the current value of the replacement of the watch is unknown to the Claimant but can be assessed by the Court.
11. Further the Claimant claims interest under section 69 of the County Courts Act 1984 on the amount found to be due to the Claimant at such rate and for such period as the Court thinks fit.
AND the Claimant claims:
(1) Damages.
(2) Interest under section 69 of the County Courts Act 1984 to be assessed.
A. M. MASUM
STATEMENT OF TRUTH
Dated etc.

redpajama_set_name: RedPajamaCommonCrawl


Apart from the more conventional Asset Class benchmarking I discussed in previous posts, I also compare my total net worth with comparable peer groups (the "Joneses"). The graph below shows my total net worth (and the stock, real estate and retirement components) over the past six years, and compares it to two relevant peer groups.
The first is the "top decile" (10%) of net worth for Australian's my age (based on the 2002 HILDA national survey results, adjusted for age effects and assumed inflation of 4%pa). By this comparison I'm doing quite well, slowly moving past the top 10% of individual NW and heading towards the top 10% "household" value.
I think it's interesting that although new people regularly make it onto the "rich list" through very rapid wealth creation (often speculative business ventures that come good), and other's drop off it just as suddenly (when their business empire collapses), taken as a group the wealth of these "super-rich" increases at a rate typical for a diversified, high-growth asset allocation.
What an interesting goal. I know that my husband would love us or the children to get onto the rich list. I am not quite that ambitious. I am happy to have enough passive income to mean that we can be happy and not have to work.


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diy live listings
Roseblood
Kathy Foster's New Project Roseblood
When the Thermals first announced they were disbanding, everyone in the indie rock scene was, understandably, a little sad. However, we don't have to be too sad for too long because bassist Kathy Foster's latest project, Roseblood, is just as enjoyable. It's a much different side to Foster, slower and sadder than the work she did in the Thermals. This past month Roseblood released a music video for their first single, "Black Veil." The song is beautiful and melancholic, full of the passion and vitality Foster is known for. The lyrics are cerebral without being pretentious, thought provoking without making the listener work too hard. It's a testament to Foster's skill and experience. The music video, directed by Jeff Rowles, is dark and gloomy. It's a clear step in the moodier, darker direction Roseblood is aiming to take.
Roseblood will be playing In The Lot, Sunday August 26th with Twin Peaks, Dude York, No Kind of Rider, and the Black Tones.
-By Avril Carrillo, photo by Jason Quigley
Published: August 11, 2018 |
best-emerging-bands-artists


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WBA Title Fights in Haiti on Wednesday
Evens Pierre will defend his WBA Fedelatin lightweight title. (Photo: Courtesy)
Three WBA title fights will take place at the Karibe Convention Center in Petionville, Haiti, this Wednesday, the 16th.
In the main event, Evens Pierre will defend his WBA Fedelatin lightweight title against Juan Carlos Salgado over a scheduled 11 rounds.
An eight-year pro (26-1, 17 KOs), the 32-year-old Port-au-Prince native won the then-vacant title in November 2014 by retiring Rene Gonzalez in the 10th. "The Sun City Kid" has successfully defended twice, most recently this April by beating Tomas Mendez via unanimous decision. Sixth-ranked by the WBA, Pierre has only suffered one defeat, beaten by Rosano Lawrence via unanimous decision in April 2010.
Fighting out of Mexico City since 2003, though out of the ring in '08 (26-6-1, 1 No Contest), 31-year-old Salgado won the WBA World super featherweight title by stopping Jorge Linares via first-round TKO in October 2009. He lost the belt in his next fight, three months later, Takashi Uchiyama stopping him by 12th-round TKO. In September 2011, Salgado took the then-vacant IBF World super featherweight title by beating Argenis Mendez via unanimous decision. He lost the belt in a March 2013 rematch, Mendez winning by fourth-round KO. The former WBA/IBF champ hasn't won since. In fact, he's lost his last five, most recently to Dante Jardon, who won by unanimous decision this March.
Also up, Azea Augustama will defend his WBA Fedelatin light heavyweight title against Wilmer Mejia over a scheduled 11 rounds.
Born in Les Gonaives, Haiti, but fighting out of Hollywood, Florida, the 33-year-old titlist is a seven-year ring vet (19-2, 11 KOs) who won the then-vacant belt by retiring Andy Perez in the third in November 2014. Fourteenth-ranked by the WBA, Augustama hasn't fought since May 2015, when he defended his title against Eduardo Mercedes, knocking him out in the third.
A southpaw, his 34-year-old opponent fights out of Irvington, New Jersey, by way of the Dominican Republic. Although a pro since 1999 (20-7-2, 15 KOs), "El Lecherito" was out of the ring in '04, '07, from '09 to '11, and in '14 and '15. Mejia last fought this September, stopping Antonio Sanchez by first-round TKO.
Finally, Wilky Campfort and Jeffrey Rosales will go a scheduled nine rounds for the vacant WBA Fedecaribe super welterweight title.
Born in Haiti but fighting out of Fort Lauderdale, Florida, 32-year-old Campfort is a seven-year ring vet, though inactive in '13 (21-3, 12 KOs), who last fought this July, losing to Patrick Szymanski by unanimous decision. "Silky" most recently won in September 2015, stopping Ronald Montes by second-round TKO.
His 24-year-old opponent, of Panama City, is a five-year ring pro (8-3-2, 2 KOs) who last fought this October, beating Jorge Andrade by unanimous decision. He's lost three of his last six.
Pound-for-Pound: Sergey Kovalev vs. Andre Ward


There are no more devoted NFL fans than Packers fans, selling out every home game since 1960 with a season ticket waiting list that's 86,000 names long! Now, this limited-edition Green Bay Packers cuckoo clock captures the spirit of loyal Packer fans every hour, on the hour!
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American National Biography
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date: 17 July 2019

Acosta, Bertrand Blanchard
(01 January 1895–01 September 1954)
Roger D. Launius
https://doi.org/10.1093/anb/9780198606697.article.2000005
Acosta, Bertrand Blanchard (01 January 1895–01 September 1954), aviation pioneer, was born in San Diego, California, the son of Aphonse Ferdinand Acosta and Martha Blanche Snook, businesspeople. Acosta became enthralled with aviation at an early age, built gliders and later powered aircraft, and taught himself to fly. Because of this interest, at age sixteen his parents enrolled him in Throop Polytechnic Institute (later the California Institute of Technology) in Pasadena so that he could study aeronautical engineering, but he never graduated. Beginning in 1911 Acosta spent almost every moment not in school working for ...
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Madrid: Ediciones del ICCMU, , 555 p.
Cambridge, Mass: Harvard University Press, 1993, 261 p.
Musica y culto divino en el real monasterio de el Escorial (1563-1837) I.
Transcripcion, introducciones, notas e indices Luis Hernandez, O.S.A.
Barcelona: Plaza & Janes Editores, S.A., 1991, 166 p.
Hispanic traditions in twentieth-century Catalan music.
With particular reference to Gerhard, Mompou, and Montsalvatage.
New York: Garland, 1989, 310 p.
An Analytical and Stylistic Study of the Canciones y Danzas for Piano.
Northern Colorado. 1983. D.A. 223 p.
Northern Colorado (Greeley). 1983. dissertation.
Barcelona: Clivis Publications, 1982, 179 p.
Metuchen, N.J.: Scarecrow Press, 1982, 1431 p.
[Madrid:] Direccion General del Patrimonio Artistico y Cultural 1977. 87 S.
Amsterdam: H.J.W. Becht, 1977, 231 p.
La musique et Federico Mompou.
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Mens en melodie. 10 (1955), s. 203-205.
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Paris: Les Editions G. Cres, 1923, 226 p.


From the left: Chadwick Cherry tomatoes, Mammoth Melting Sugar Snap Peas, Maxibel Haricot Vert Bush Bean. Hope you'll enjoy your dinner as much as we will!
This entry was posted in Gardening, Self-Sufficiency, Simple and tagged garden, green bean, harvest, peas, tomato, vegetables. Bookmark the permalink.
Oh, man, you're so far ahead of us down there in Atlanta! But I see in your photo the sign of things to come!
We have a ways yet before we get a harvest. Seeing posts like yours makes me impatient, just knowing what is on the way!
Congrats on your harvest! Don't you just love pulling food out of the garden?


he looks around at the playmakers that surround him in the Panthers' locker room."The talent level we have on this team is extremely scary Youth Lavonte David Jersey ," Newton said.The Panthers proved that again Sunday.Newton completed 19 of 25 passes for 247 yards and two touchdowns, running back Christian McCaffrey racked up 157 total yards and scored twice and second-year wide receiver Curtis Samuel scored on a 33-yard double reverse and hauled in a 19-yard TD catch midway through the fourth quarter to seal Carolina's 42-28 win over the Tampa Bay Buccaneers on Sunday.The Panthers (6-2) are on a roll midway through the season, scoring 99 points in the last nine quarters.They have wide receivers that can run the ball, running backs that can catch, a big body receiver, a third-down receiving specialist, one of the best pass-catching tight ends in the league and, of course, a one-time league MVP at quarterback who can do it all.Those weapons were all on display in the first half as the Panthers scored touchdowns on five straight possessions to build a 35-7 lead en route to their 10th straight win at home.Even a little "Fitzmagic" wasn't enough for the Buccaneers (3-5).Ryan Fitzpatrick, who started in place of the turnover-prone Jameis Winston, finished with 243 yards passing and four touchdowns — two each to Adam Humphries and O.J. Howard — and led the Bucs back to within 35-28 in the fourth quarter before running out of steam.Fitzpatrick threw two costly interceptions — one on the game's second possession which led to Carolina's first touchdown, and other late in the fourth quarter that sealed the Bucs' fate."We know we have the talent, it's just we can't keep digging ourselves in these holes, especially on the road," Fitzpatrick said.The deficit — and Carolina's offensive firepower — proved too much.Tight end Greg Olsen called the versatility the Panthers now have on offense with players like McCaffrey, Samuel and D.J. Moore is unlike anything he's seen since his arrival in Carolina in 2011."We have guys who are so explosive, so dynamic and so good in the open space," Olsen said. "We can give them balls on handoffs Peyton Barber Jersey , throw it to them all — they're very unique in that regard. I don't know what we have had this many guys who are that dynamic with the ball in their hands."That was evident throughout.McCaffrey leaped a defender on a reception in the flat and kept going, racing 32 yards for a first down. Samuel's 33-yard TD on the reverse included the speedster reversing field and running a combined 103 yards , according to NFL's Next Gen Stats. And Olsen, the cagey veteran, hauled in a one-handed catch in the end zone — his third TD in three weeks."We were playing with momentum and when you're playing like that, we have a lot of juice coming our way so it does make it very fun," McCaffrey said.Said Newton: "When it's clicking, it's clicking."BREAKING THE PATTERNBucs coach Dirk Koetter is eager to find a solution for his team, which seems to be stuck in a repeating pattern."We go out, we get behind, we get killed in the second quarter, then rally like (heck) in the third quarter and then everybody thinks we're back in it and then we fade off at the end," Koetter said. "That's definitely the pattern that we're in. If I knew one thing to fix it I'd do it right now, but I don't know what that is."ADDISON TURNS IN TRIFECTAPanthers defensive end Mario Addison had a big game with three sacks to raise his team-leading total to 7陆."I'm a pretty strong guy," said the 6-foor-3, 260-pound Addison. "People underestimate me because I look kind of small but I pack a punch. By the time they miss and my hands get on the inside of them, I'm running them back and they're like 'Dang, this guy's stronger than I thought.'"SLAMMING THE DOORThe Panthers have been touting James Bradberry as their shutdown cornerback and he did quite a number on Tampa Bay's Mike Evans Authentic Ryan Smith Jersey , who finished with one catch for 16 yards despite being targeted 10 times.Panthers coach Ron Rivera called Bradberry's defense "as solid as it gets."THIEVES AVENUEThe Panthers secondary is coming up with big turnovers this season. Carolina has 11 interceptions at the midway point of the season after just 10 picks last season. Jackson, a rookie, has four of them."The secondary is shaping up nicely and the more they play together the more chances they will have," Rivera said.NATIONAL ANTHEMPanthers safety Eric Reid took a knee during the national anthem to protest racial and social injustice.INJURIESBuccaneers: None reported.Panthers: Reid left in the fourth quarter with a shoulder injury, but returned to the game.UP NEXTBuccaneers: Host Washington on Sunday.Panthers: Play four of their next five games on the road, beginning Thursday night at Pittsburgh.Bucs offense plays well in preseason victory at Miami The Tampa Bay Buccaneers' offense got things going early on down in Miami against the Dolphins. With veteran quarterback Ryan Fitzpatrick leading the first-team offense, the Bucs were able to move with ease offensively.Fitzpatrick marched the team down field on their first possession for a touchdown via the legs of running back Peyton Barber. The aged signal caller finished the game 6-for-8 for 55 yards. There wasn't much explosiveness, but Fitzpatrick did manage the game well.Quarterback Jameis Winston also saw some action. He finished his time out on the field 11-for-13 for 102 yards. But Ryan Griffin was the story of the evening as he helped the team to a touchdown in the third quarter and marched the team back late in the fourth quarter to set up what was the game winning field goal. Griffin finished the second half of the game 20-for-26 for 179 yards.Notable StatsPeyton Barber: 4 carries for 21 yards and a touchdownRonald Jones II: 8 carries and a touchdownCameron Brate: 5 receptions for 48 yardsMike Evans: 2 receptions for 26 yardsGerald McCoy: 1 sackCarlton Davis: 5 tackles 2 passes defensedNoah Spence: .5 sackBucs NotesRB Peyton Barber - who has led Tampa Bay in rushing in each of the past two preseasons – scored his first career preseason rushing touchdown, ending a six-play, 57-yard drive that lasted 3:07.In the first quarter, DT Gerald McCoy dropped Dolphins QB David Fales for a six-yard loss. McCoy now has 3.0 career preseason sacks (0.5 in 2016, 0.5 in 2015, 1.0 in 2014).In the second quarter, CB Ryan Smith forced a fumble that was recovered by S Isaiah Johnson. It is the first career preseason forced fumble for Smith and the first career preseason fumble recovery for Johnson.Following the fumble recovery, Tampa Bay scored a touchdown on a one-yard rush from RB Ronald Jones.DE Patrick O'Connor and DE Noah Spence shared a sack in the second quarter, bringing down Dolphins QB Brock Osweiler for no gain. O'Connor had a sack with Detroit in the 2017 preseason. Spence now has three career preseason sacks (1.0 in 2016 & 2017).In the second quarter, after the Dolphins went three-and-out, the Buccaneers drove 40 yards in six plays Youth Justin Evans Jersey , setting up a 27-yard field goal from K Chandler Catanzaro.Tampa Bay had a 17-play, 88-yard drive lasting 7:44 in the third quarter, culminating in a 10-yard touchdown catch by TE Alan Cross from QB Ryan Griffin. It is Cross's first career preseason touchdown catch and Griffin's third career preseason passing touchdown (1 in 2016, 1 in 2015 with the New Orleans Saints).With 23 seconds remaining in the game, Catanzaro connected on a 26-yard field goal to give Tampa Bay a 26-24 lead. Catanzaro's field goal ended a seven-play, 67-yard drive that lasted just 1:27.On Miami's final possession of the game, CB Ryan Smith intercepted a pass from Dolphins QB Bryce Petty.Players making Buccaneers preseason debut: DT Beau Allen, K Chandler Catanzaro, DE Will Clarke, DE Vinny Curry, LS Jake Ferris, OL Adam Gettis, LB Nigel Harris, C Ryan Jensen, WR Jake Lampman, RB Dare Ogunbowale, DE Jason Pierre-Paul, DE Patrick O'Connor http://www.buccaneersauthorizedshops.com/authentic-chris-godwin-jersey , T Brad Seaton.Players making NFL preseason debut: DE Kiante Anderson, WR Sergio Bailey, DT Nathan Bazata, OL Alex Cappa, LB Jack Cichy, CB Carlton Davis III, DE Demone Harris, G Ruben Holcomb, TE Tanner Hudson, RB Ronald Jones II, S Josh Liddell, CB Marko Myers, DE Evan Perrizo, LB Shaheed Salmon, CB M.J. Stewart, WR Justin Watson, S Jordan Whitehead.


Indie Retro News: Days of War - Driven Arts WW2 shooter released via Steam Early Access!
Days of War - Driven Arts WW2 shooter released via Steam Early Access!
Driven Arts has announced that the Kickstarter success of Days of War is now available via Steam Early Access. This is a fast paced online multiplayer game that aims to revive the style of classic WW2 shooters, where your combat skills and knowledge of the map will be put to the test. You will fight with up to 32 other players either as the Americans or the Germans, on the beaches at Omaha, inland Normandy themed maps Carentan and Thunder, or battle for the Colmar Pocket in the snowy village of Kaysersberg!
Driven Arts has also said these iconic locations draw inspiration from Saving Private Ryan, the Band of Brothers TV series and other real world settings. Furthermore your chosen soldier in these deadly battle torn landscapes can take the role of Marksman, Rifleman, Assault, Support, Specialist, Shotgunner, Machine Gunner, Sniper or Rocket Soldier, with each faction having their own unique weapons!


Simulate basic population genetics on fake creatures' DNA. Concepts of mutation, crossover, fitness distribution covered.
This script will simulate a generation of "creatures" generation after generation.
Each creature has one allele in their "DNA" for color and is passed to offspring based on fundamentals of genetics (crossover, mutation).
Depending on how close the creature's color allele is to the ideal allele, it is given a fitness value which affects its chances of reproducing with another creature.
A percentage of "Top" fitness organisms will asexually reproduce to keep their ideal DNA in the mating pool.


Lung Cancer is occasionally observed in patients with Idiopathic Pulmonary Fibrosis (IPF). We sought to describe the epidemiologic and clinical characteristics of lung cancer for patients with IPF and other interstitial lung disease (ILD) using institutional and statewide data registries.
We conducted a retrospective analysis of IPF and non-IPF ILD patients from the ILD center registry, to compare with lung cancer registries at the University of Pittsburgh as well as with population data of lung cancer obtained from Pennsylvania Department of Health between 2000 and 2015.
Among 1108 IPF patients, 31 patients were identified with IPF and lung cancer. The age-adjusted standard incidence ratio of lung cancer was 3.34 (with IPF) and 2.3 (with non-IPF ILD) (between-group Hazard ratio = 1.4, p = 0.3). Lung cancer worsened the mortality of IPF (p < 0.001). Lung cancer with IPF had higher mortality compared to lung cancer in non-IPF ILD (Hazard ratio = 6.2, p = 0.001). Lung cancer among IPF was characterized by a predilection for lower lobes (63% vs. 26% in non-IPF lung cancer, p < 0.001) and by squamous cell histology (41% vs. 29%, p = 0.07). Increased incidence of lung cancer was observed among single lung transplant (SLT) recipients for IPF (13 out of 97, 13.4%), with increased mortality compared to SLT for IPF without lung cancer (p = 0.028) during observational period.
Lung cancer is approximately 3.34 times more frequently diagnosed in IPF patients compared to general population, and associated with worse prognosis compared with IPF without lung cancer, with squamous cell carcinoma and lower lobe predilection. The causality between non-smoking IPF patients and lung cancer is to be determined.
Idiopathic pulmonary fibrosis (IPF) is a fatal pulmonary condition characterized by the accumulation of activated fibroblasts and extracellular matrix within the lung parenchyma that exhibits progressive, but unpredictable disease course [1, 2]. Two medications are currently approved for the treatment of IPF, but their effects on mortality and quality-of-life in IPF are uncertain [3, 4]. IPF is the most common type of the idiopathic interstitial pneumonias , and its distinctive radiographic and pathologic characteristics, as well as course of disease differentiate it from other types of interstitial lung disease (ILD) [6, 7]. Although the link between IPF and lung cancer has been known for years , estimates of the prevalence of lung cancer among IPF have varied widely [9, 10]. The effect of a lung cancer diagnosis on the prognosis of IPF is also an unsettled question. Some have suggested IPF and lung cancer exhibit no differences in survival rate compared to IPF without lung cancer [11–14], but a more recent study has supported a worse prognosis .
In this context, the purpose of our study was to compare primary lung cancers in a large cohort of patients with IPF and non-IPF ILD to lung cancers from population data in order to describe the characteristics of and to estimate the incidence and prevalence of lung cancer in patients with IPF and non-IPF ILD.
The ILD registry at the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and the Lung Cancer registry at the Hillman Cancer Center were approved by the Institutional Review Board at the University of Pittsburgh.
Data from the Simmons Center for Interstitial Lung Disease were collected from January 2000 to December 2015. The Simmons registry diagnosis was based on established American Thoracic Society and European Respiratory Society clinical criteria [1, 16]. For lung cancer, registry data were obtained from the Hillman Cancer Center during the same observation period. Both registries are linked to providers' clinics, and are actively followed, and vital status is regularly updated from the Social Security Database. Patients from the ILD registry were characterized as having IPF or non-IPF ILD. Non-IPF ILD refers to ILD caused by a disease other than IPF. The combination of the two registries (referred as 'institutional data') according to each disease status of IPF, non-IPF ILD, and lung cancer is shown in Fig. 1. To obtain the radiographic evidence of emphysema among the two institutional registries, natural language process was used to extract keywords including 'emphysema' or 'emphysematous', with its positive and negative terms from the chest computed tomography (CT) radiology reports.
Epidemiologic data of new lung cancer cases were obtained from the Cancer Registry of the Department of Health of the Commonwealth of Pennsylvania, which is a part of the National Program of Cancer Registry. The following queries were used: (1) demographic data: age, gender, ethnicity; (2) Clinical data: age at lung cancer diagnosis, cancer stage according to American Joint Committee on Cancer staging guidelines [17, 18], histology, location, and mortality. The presence of IPF or non-IPF ILD was not identifiable from this data, as they were not collected in this epidemiologic registry. Age-related State Census data was obtained from the Enterprise Data Dissemination Informatics Exchange (EDDIE) for calculating population cancer statistics (http://www.statistics.health.pa.gov/StatisticalResources/EDDIE, last accessed May 15, 2017).
To extract the data, a standard application programming interface, Microsoft Open Database Connectivity (Microsoft Corporation, Redmond, WA) was used. Lung cancers were classified following the World Health Organization classification . TNM system was used to stage lung cancers at the time of diagnosis. Diagnosis of IPF and other ILDs, as well as lung cancer were based on the codebook of International Classification of Disease, Ninth Edition (ICD-9) at the time of diagnosis. Time of the diagnosis for IPF as well as non-IPF ILD was defined by the first ILD center visit when the ICD-9 code was given. Age-adjusted standard incidence ratio of lung cancer in IPF and non-IPF ILD patients were compared with the DOH data. For the calculation of the survival rate, the time from the time of diagnosis of IPF or non-IPF ILD to death (survival time) were compared. The location of lung cancers, the histologic phenotypes, and the stage at diagnosis were compared.
Continuous and categorical variables were compared between different groups using the Kruskal-Wallis or Fisher's exact test. Log rank test was performed to compare the survival function in lung cancer patients with and without IPF. Standardized incidence ratio was used to compare age-adjusted incidence of lung cancer between IPF patient and lung cancer registry information from Pennsylvania DOH. Age-adjusted standardized incidence ratio was calculated defining each expected and observed cases for group is based on person-years. The person-year was calculated by the sum of the time between the date of diagnosis of IPF or non-IPF ILD and either the date of death, or the end of the observation period (December 31, 2015) for each age bracket. All analyses were performed in STATA 14.2 (StataCorp., College Station, TX).
We identified 1953 patients including 1108 IPF patients and 841 patients with non-IPF ILD diagnosis from the Simmons ILD data (Fig. 1). The baseline demographic profiles of institutional IPF patients were compared to non-IPF ILD patients (Table 1). When compared with non-IPF ILD group, IPF patients were older at diagnosis (median of 69 vs 59 years old), more frequently Caucasian (91% vs 85%), and male (59% vs 38%, all p < 0.001). The difference in prevalence of lung cancer between IPF and non-IPF ILD was not statistically significant (2.8 vs 1.9%, p = 0.12). More IPF patients than non-IPF ILD patients were smokers (66% vs 57%, p = 0.001). All-cause mortality was higher in IPF than non-IPF ILD group (47 vs 12%, p < 0.001). From the Hillman Cancer Center Registry, 4207 patients were identified for review for lung cancer of all histologic subtypes including 4176 cases without IPF diagnosis. Following cross-matching of the two registries, we found 31 patients with both IPF and lung cancer and 16 patients with non-IPF ILD and lung cancer. Primary etiologies included in non-IPF ILD group are summarized in Additional file 1: Table S1.
The demographic characteristics of patients with lung cancer and IPF were compared to lung cancer without IPF from the Hillman Cancer Center Registry, as well as with lung cancer from the population data acquired from Department of Health (DOH) (Table 2). From the DOH data, the total obtained number of lung cancer cases from 2000 to 2015 was 156,032. After excluding duplicated identifiers (n = 3951) and non-solid and non-primary (either metastatic disease from other primaries or unknown primary) (n = 47,127), 104,954 patients were included in the final analysis.
IPF patients with lung cancer were not significantly different in terms of age (65 vs 67 years, p = 0.2), gender (61 vs 48% male, p = 0.15), and race (97 vs 88% Caucasian, p = 0.14) compared to lung cancer patients without IPF from the Hillman Cancer Center Registry. Fewer IPF patients with lung cancer were former or current smokers compared to lung cancer patients without IPF (77 vs. 90%, p < 0.001), with 7 never-smokers (23%) were identified from IPF and lung cancer group. No smoking history data were available from the Pennsylvania Department of Health database. IPF patients with lung cancer were, however, younger compared to the population data for lung cancer (65 vs 69 years, p = 0.03). There was no difference in the gender and race between the ILD data and population data. The mortality between lung cancer with IPF and lung cancer without IPF was different when compared within the institution (84 vs 63%, p = 0.013). However, this difference was not observed when institutional IPF patients with co-morbid lung cancer were compared to population data (84 vs 75%, p = 0.2) over the 15 years of observational period. To better understand the prognosis of IPF with lung cancer, we examined survival time as defined as time interval from the date of lung cancer diagnosis to the date of death. In the institutional cohort, patients with lung cancer without IPF had a significantly longer survival time, compared to lung cancer patients with IPF (median survival time 5 vs 13 months, p = 0.002).
We next examined the cumulative incidence of lung cancer in IPF and non-IPF ILD patients. The median time to the discovery of lung cancer after the diagnosis of IPF was 53 months (interquartile range (IQR) 25–77 months), and 55 months (IQR 44–62 months) in non-IPF ILD. Although there was no observed difference in the median time to the discovery of lung cancer between these groups, there did appear to be increased incidence of lung cancer in the first 2 years after diagnosis in the IPF group which persisted until year four (Fig. 2).
Observed incidence of lung cancer (Table 3) in general population was calculated within different age brackets, and showed that the rate among IPF patients was 3.34 times higher (95% confidence interval 2.3–4.7) and in non-IPF ILD patients 2.3 times higher (95%CI 1.3–3.6) compared to general population. To drill down the cancer risk in non-IPF ILD cases, the non-IPF ILD group was subdivided further into ILD associated with autoimmunity, hypersensitivity pneumonitis (HP), pneumoconiosis, and smoking-related ILDs (eosinophilic granuloma, respiratory bronchiolitis-associated interstitial lung disease, and desquamative interstitial pneumonia). No lung cancers were observed in the HP or pneumoconiosis groups. Among non-IPF ILD patients, 508 patients with ILD related to autoimmunity (including systemic sclerosis, rheumatoid arthritis, polymyositis/dermatomyositis, Sjogren's disease, and mixed connective tissue disease) were identified, among them 12 lung cancer cases diagnosed within the observation period. When the autoimmunity group is considered alone, the age-adjusted incidence of lung cancer was 4.95 times higher than general population (95% CI 2.7–8.4). The rate of non-smokers among autoimmune-related ILD patients were 47% (123 out of 261 known history of smoking). Among patients with HP (n = 109), no lung cancer was identified, in which 48% (28 out of 58 known history of smoking) were smokers. From a small group of patients (n = 47) with smoking-related ILDs, two cases of lung cancer were found.
The survival probabilities for IPF without lung cancer (n = 1077) and IPF with lung cancer (n = 31) were compared over time. Figure 3 illustrates Kaplan-Meier curves for institutional data - IPF without lung cancer and IPF with lung cancer groups, where statistically significant (p < 0.001) lower survival rate over time was observed for IPF and lung cancer patients compared to IPF patients without lung cancer. The trend in cumulative incidences between the two groups showed no major differences across 15 years of accumulated follow-up period of variable lengths of observed individual cases.
The clinical characteristics of lung cancer with a diagnosis of IPF and non-IPF ILD are described in Table 4. The primary site of the lung cancer for IPF patients showed more frequent lower lobe predilection compared to population lung cancer data (63% vs. 36%, p < 0.001). On the other hand, lung cancer diagnosed from institutional non-IPF ILD patients demonstrated no statistically significant differences in location compared to population lung cancer data (p = 0.2). The most common type of lung cancer in IPF patient to be squamous cell cancer, higher in IPF patients (41%) compared to non-IPF ILD patients (19%) with lung cancer within the institution. Squamous cancer in IPF was also more common compared with squamous cell cancer ratio in population data (29%) but not reaching statistical significance (p = 0.07). The histology of lung cancer was not significantly different between non-IPF ILD patients and general population (p = 0.4). No significant differences in distribution of lung cancer stage in IPF compared to patients with lung cancer without IPF were identified in the DOH data (p = 0.6). The similarity in the cancer stage distribution also exists when compared with the institutional non-IPF ILD patients with lung cancer data (p = 0.8), nor with the population data (p = 0.6). Lung cancer patients with non-IPF ILD also demonstrated no differences compared to population data. Individual level descriptive analysis for all 31 patients diagnosed with IPF and lung cancer are available (Additional file 1: Table S2).
Among our 1108 IPF patients, 233 (21%) cases were found to have emphysema as a comorbid condition during the clinic encounters. From 841 non-IPF ILD patients, 156 (19%) had a diagnosis of emphysema. For the patients diagnosed with lung cancer along with IPF, 17 patients had a diagnosis of emphysema. We observed that radiologic emphysema was overrepresented in IPF patients with lung cancer (OR 5.2) compared to non-IPF patients from Hillman Cancer Center data.
Transplantation and immunosuppression have been associated with an increased rate of cancer development. This is especially true as single lung transplant has been known for higher rate of lung cancer in native lung, ranging from 6.9–9.8% [20, 21]. To estimate the effect of single lung transplant on development of lung cancer for IPF patients, a subgroup analysis was performed (Additional file 1: Table S3) within the institutional registry data. With the data collected until 2014, a total of 97 IPF with single lung transplanted patients were enrolled in our registry. Among them, 13 cases of lung cancer were identified in the native lung (13.4%) following single lung transplant (SLT). There was no difference in age, gender, ethnicity, or smoking history, but the mortality of single lung transplant recipients who developed lung cancer (12 out of 13 patients, 92%) were significantly higher than single lung transplant without lung cancer (49 out of 84, 59%, p = 0.028) during follow-up period.
The association between IPF and lung cancer has been observed for years, although estimates of the risk have varied widely. Co-morbid lung cancer represents a very challenging problem for the clinician. In this study, we sought to identify the clinical characteristics of lung cancer among patients with IPF and non-IPF ILD from our institutional data and to compare these data from population data. In our study, which represents the largest review in the United States, we have found that patients with IPF exhibited a 3.34-fold higher incidence of lung cancer compared to the general population who developed lung cancer. IPF patients showed a statistically significant worse mortality rate over observation period compared to lung cancer patients without IPF. Consistent with several previous studies, lung cancer in IPF was observed more frequently in the lower lobes, with a borderline association between IPF and the squamous cell carcinoma histology, as observed previously [22–25]. Overall, our data suggest that lung cancer in IPF is phenotypically distinctive from "sporadic" lung cancer, and exhibits worse prognosis compared to IPF without lung cancer, or lung cancer without IPF.
We found that single lung transplant patients from IPF exhibited a higher prevalence of lung cancer, and the development of lung cancer in this group was associated with higher mortality during follow-up period. When the native IPF lung is exposed to immunosuppressive medications to prevent rejection from lung transplant, the risk of cancer may be accentuated by loss of immune-mediated "tumor surveillance" . This raises the question if single lung transplant represents an additional risk factor for the development of lung cancer in IPF. While our numbers are small, the suggestion is that indeed, transplant enhances the risk of lung cancer. Furthermore, it begs the highly speculative question if IPF patients should undergo double lung transplant as a potential "cure" to the lung cancer risk. Additional study of single lung transplant for all indications might help elucidate the specific risk of lung cancer in IPF associated with immunosuppression.
The subject of IPF and lung cancer has been studied in diverse ethnic groups and health care systems. One of the largest studies of health care databases identified a relative risk 7.3 for lung cancer in IPF patients in the United Kingdom (UK) , which was validated by analysis of an overlapping UK database where 1064 IPF patients were studied identifying a nearly fivefold increased rate of lung cancer . Our estimate for incidence of lung cancer among IPF was lower at 3.3, showing little change after controlling for smoking in the British study . While smoking rates were similar in the UK studies between IPF and control patients, smoking was less common in IPF patients with lung cancer compared to patients with lung cancer alone in our institutional data. These data corroborate the idea that IPF is a risk factor for lung cancer independent of smoking. It is possible that smoking may account for the observed prevalence of lung cancer in IPF of 13% in an Italian cohort , which is significantly higher than our observed prevalence of 2.8%. The number of never smokers in our cohort is at least three-fold higher than the Italian cohort. Another UK study cohort  showed that most IPF patients with lung cancer diagnosed had smoking histories (never smoker n = 2, 4.5%), along with other IPF and lung cancer studies [13, 27, 28]. In our analysis, the IPF patients without a history of smoking did not exhibit an increased risk of lung cancer, which suggests that cigarette smoking could be an important contributor of lung cancer development. The role of genetics in IPF could play a pivotal role in the development of lung cancer , but the mechanistic pathway has not been fully elucidated. Another factor that could drive the prevalence of lung cancer in pulmonary fibrosis cohort would be combined pulmonary fibrosis with emphysema (CPFE) . Despite the higher lung cancer rate for IPF patients with radiologic emphysema (OR 5.2), the distribution of radiologic diagnosis of emphysema varied from 12 years before to 3 months after the diagnosis of lung cancer, and definitive quantification of impact of emphysema was hard to estimate from our results. In addition, concern of surveillance bias exists in our data because of the frequency of chest CTs in this population. Further study is needed to determine a dose-response effect for lung cancer risk in IPF possibly based on volumetric CT analysis.
Cancer risk in the non-IPF ILD population is well known. Some phenotypes of non-IPF ILD including polymyositis/dermatomyositis , rheumatoid arthritis , and systemic sclerosis  are known to be associated with increased risk for lung cancer. We found a prevalence of lung cancer in 1.9% among non-IPF ILD patients. This appears to be lower than some previously published estimates [34, 35], as well as a recent comprehensive study . Thus, the molecular underpinnings of lung cancer risk in non-IPF ILD may be different than in IPF. Among non-IPF ILD patients, our analysis showed 4.95-fold increased age-adjusted incident rate of lung cancer among autoimmune disease-related ILD within the observation period. However, it is difficult to determine if the increased risk of lung cancer is associated with an autoimmune process versus immunosuppressive therapy which is needed to treat autoimmune disease. Further study is needed to quantify these risks at both the population level and at the molecular level.
Previous studies have suggested that mortality of patients with lung cancer and IPF was no greater than for IPF patients without lung cancer [23, 37]. More recent studies, however, have argued there that the mortality of lung cancer in IPF patients is higher than for lung cancer alone [15, 25] and that the presence of IPF is associated with a prognosis worse than lung cancer. We found that lung cancer worsened the prognosis of IPF. Based on the Simmons data and DOH data, however, having IPF did not increase the overall mortality of lung cancer in the general population in a statistically significant way. What explains this discrepancy? This observation may be influenced by other important prognostic information in the general population that are not available to us for study such as smoking status. The clinically relevant question here would be whether a screening process for lung cancer among IPF patients would yield survival benefit. However, there are no current recommendations to guide clinicians how to diagnose and manage lung cancer in IPF. It is unclear how treatment decisions should be made at an individual level. Does impaired pulmonary function affect treatment decisions? Stage at diagnosis did not differ between IPF and non IPF patients. These data highlight many of the unanswered questions surrounding lung cancer and IPF.
Recently, the anti-cancer effect of IPF therapy has been suggested in recent studies [38–40]. This could raise an interesting question, whether the risk of lung cancer could be affected for our registry population with the use of pirfenidone. However, because IPF therapy was officially approved by the United States Food and Drug Administration in November 2014, and most of our patients' data were collected beforehand, we cannot determine if therapy changes lung cancer risk in IPF. Thus, the direct effect of pirfenidone in our registry data on the development cannot be assessed in this study.
We recognize that there are several limitations to this study. This single-center study with retrospective database review may underrepresent the IPF and lung cancer population. Conversely, referral bias may inflate the prevalence as sicker and more complicated patients seek care at the tertiary specialty center. Surveillance bias for lung cancer could exist, with IPF or non-IPF ILD patients tend to visit clinic more often for diagnostic work-up or symptoms, while early-stage lung cancers may be asymptomatic. Evolving diagnostic criteria for IPF and ILD over the last 15 years may be associated with misclassification, with no clear unifying interpretation present for the changing criteria . These factors may have potentially affected our analysis on the prevalence and survival trajectories because the possibility of misclassification over time. Third, some of our referrals were from out-of-state and might not be represented by the PA population data. The population data for lung cancer obtained from the Pennsylvania Department of Health lack smoking history and the exact time of lung cancer diagnosis (data only has year of diagnosis). For these reasons, assessment of risk factors for lung cancer and head-to-head survival analysis between institutional and the DOH data were not possible in this study.
The incidence of lung cancer was higher among IPF patients compared to general population or ILD patients. Lung cancers in IPF was observed more commonly in never smokers and demonstrated predilection for the lower lobe, and the squamous cell histology may predominate. In addition, lung cancer negatively impacts the prognosis of IPF. Further study is needed to elucidate how the IPF phenotype alters the lung cancer phenotype and if screening for lung cancer in this population will ultimately impact the course of the disease.
The authors wish to acknowledge the efforts of Karla Stewart, BS, CTR, Thoracic Research Registrar with the UPMC Network Cancer Registry. Population data were supplied by the Bureau of Health Statistics & Registries, Pennsylvania Department of Health, Harrisburg, Pennsylvania. The Pennsylvania Department of Health specifically disclaims responsibility for any analyses, interpretations or conclusions.
This study was supported in part by the National Institute of Health (NIH) funding R01-HL126990 (DJK). Registry Information Services from Hillman Cancer Center is managed with funding from NIH P30CA047904.
Institutional data from Simmons Center for Interstitial Lung Disease and Hillman Cancer Center of University of Pittsburgh are not publicly available without the center's approval due to regulatory restrictions, but could be available from corresponding author on reasonable request. Population data from Department of Health for the Commonwealth of Pennsylvania are public data, and available through the Bureau of Health Statistics & Registries, Harrisburg, Pennsylvania.
JHY, MN, KG, NK, and DJK participated in the concept and design of the study. JHY, XC, RZ, KV, KL, TB, KG, and DJK participated in the acquisition of the data. JHY, MN, XC performed the data analysis. JHY, MN, DJK drafted the initial manuscript. All authors critically revised the manuscript and approved the final version for submission.
The ILD registry at the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and the Lung Cancer registry at the Hillman Cancer Center were approved by the Institutional Review Board (# 0307127, modified 0307127–12) at the University of Pittsburgh.
Both registries' data were collected with consent from individual patient at the time of enrollment throughout data collection period.
JHY, MN, XC, JC, KV, KL, DOW and SY have nothing to disclose.
JS reports grants from Boehringer, grants and personal fees from Roche, personal fees from Rovi, outside the submitted work. TB reports personal fees from AbbVIE and Regeneron, outside the submitted work. NK reports grant and personal fees from Biogen Idec, personal fees from MMI, non-financial support from Actelion, non-financial support from Miragen, non-financial support from Astra Zeneca, non-financial support from GSK, personal fees from Pilant, and is a consultant to Samumed, Numedii, which are outside the submitted work. NK is also a member of the Scientific Advisory Committee, the Research Advisory Forum, and the Board of the Pulmonary Fibrosis Foundation, as well as serving as Deputy Editor of Thorax and BMJ. KG reports personal fees from Bayer, outside the submitted work. DJK reports research grant funding from Regeneron, outside the submitted work.


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Camavinga's agent responds to claims Arsenal are preparing a 'shock' loan move for the Real Madrid star
Arsenal target Eduardo Camavinga celebrates Credit: Alamy
Eduardo Camavinga's agent has dismissed reports that the Real Madrid midfielder could leave the club on loan amid reports linking him with Arsenal.
The Gunners have already been very active in the current market with Mikel Arteta and technical director Edu swooping for Brighton's Leandro Trossard after missing out Mykhaylo Mudryk to Chelsea.
Widespread reports yesterday also claimed that they are closing in on the signing of Spezia centre-back Jakub Kiwior with a deal around €25m agreed.
And there are rumours around that Arsenal want to continue their spending with one report claiming the Gunners want to bring Camavinga to the Emirates Stadium on loan until the end of the season in a 'shock' deal.
It didn't seem believable at the time and now the Real Madrid midfielder's agent has moved to dismiss any chance of it happening.
When Camavinga's agent Joshua Barnett was asked by transfer expert Fabrizio Romano about the potential deal, he replied: "There's no truth in that.
"Of course every club in the world would want him, but he's very happy in Real Madrid and Real Madrid are very happy with Camavinga."
Trossard was confirmed as a new Arsenal player on Friday and the Belgium international can't wait to get started.
"They told me they really like me as a player, that I would really suit the system and how they want to play," Trossard told the club's official website.
"It helps me that I'm versatile and that I can play in different positions. They're looking forward to working with me and vice versa. I'm really excited to work with them and I think Mikel is a top coach."
Trossard added: "I'm really excited to get started. This is a big club and I'm ready to show the fans what I can do. Everyone has seen how well we're doing already and I'm here to help achieve their dreams – including myself.
"I'm going to take it day by day, work hard and try to help the team to achieve their goals. [I want to] get better as well. I know the manager is a great coach and I hope to be involved in doing great things and getting better as a player in every aspect.
"I'm really excited to see the fans in the stadium. I hope I can give you my all. I want to try and create as many magic moments as possible, and hopefully we can celebrate together.
"[The club] has so much history and I want to be part of that history going on. That's why I joined this project. I'm really excited to be here. I want to show myself to all the fans and on the biggest stage."
READ MORE: Transfer gossip: Man Utd target 'stunning summer swoop' for Prem star; Arsenal plot 'shock bid'
The article Camavinga's agent responds to claims Arsenal are preparing a 'shock' loan move for the Real Madrid star appeared first on Football365.com.
Singer-songwriter Lunadira is first Malaysian artist to perform on COLORS
KUALA LUMPUR, Jan 27 — Singer-songwriter Lunadira is the first Malaysian artist featured on COLORS. In a recorded perfo...
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Iconic Brand Award Brave Brand of the Year Award Anniversary Dinner About Contact Us
Duracell, 1975
Voting has now closed you'll have the chance to decide the ultimate iconic brand via a live vote at our spectacular Diamond Anniversary Dinner in London, 27 November.
It was a good year for Charlie. As Charlie Chaplin was knighted by the Queen, British women were dousing themselves in a new Revlon perfume called Charlie. Remember the song? "There's a fragrance that's here to stay, And they call it… Charlie, It's kind of fresh, kind of NOW – Charlie! It's kind of new, kind of WOW – Charlie!"
Young ladies were introduced to the delights of the Parker Lady Pens by actress Penelope Keith posing as Madame at a Swiss finishing school. "…your final and most important lesson: how to spend Daddy's lovely money. Cheque books open girls, pens at the ready! A pen with style! A pen with à la!" The Duracell bunnies also made their debut this year, playing the drums "on and on," as kids were told that milk is good for you.
Meanwhile, the Kevin Keegan perm was the height of fashion and Womblemania was gripping the UK. We were enthralled by a manic hotelier called Basil Fawlty, the shades of grey in The Sweeney, and a man with a big cigar, Jim'll Fix it. As Margaret Thatcher won a landslide victory to rule the Tories, Wonder Woman kerpowed onto our TV screens.
We were told the Eight-Track Tape would revolutionise the way we listened to music in our cars, but the chunky cartridges filled with fraying tape didn't hang around for long.
Quietly across the Atlantic, a 20 year-old Harvard student called Bill Gates launched a company called Microsoft in Albuquerque, New Mexico, USA. And David Ogilvy developed the "Don't Leave Home Without Them" ad campaign for American Express Traveller's Cheques, featuring Oscar Award-winning actor Karl Malden, who became the public face of the brand for 25 years.
Snapshot 1975
Brand Value – $2,036m
Brand Value – Methodology
Books: The History Man by Malcolm Bradbury
Events: The Watergate scandal; the London Hilton Hotel is bombed by the IRA; Pol Pot becomes Prime Minister of Cambodia; Francisco Franco dies, signalling end of his 36 year dictatorship of Spain
Films: Jaws; Shampoo; The Rocky Horror Show
Music: Bohemian Rhapsody by Queen spends nine weeks at number one in UK charts; the tartan-clad Bay City Rollers and Rastafarian Bob Marley were unstoppable
#brandoftheyear
Anniversary Dinner
I would like to register my interest in booking a table at The Marketing Society Anniversary Dinner. Please contact me
Thank You for your interest we will be in touch.
© 2019 Marketing Society


PFA - the acronym for the Perikian Free Army of ancient Bajor.
p�losie wine � sweet fruit beverage that Quark had a case of in storage, which he hoped to use on his dinner date with Lieutenant Ro before it turned sour.
PTP One � post-traumatic psychology test administered at Starfleet Academy; the Klingons have a version of it as well.
padd � personal access data device; commonly used for reading, record keeping and research.
Padilla - the most populous of the five major cities on Europa Nova; the Intrepid and the Goldblatt�s Folly were assigned the task of evacuating Padilla.
pagh � the Bajoran word for �life force� or �soul�.
pagh�tem�far � Bajoran concept of a sacred vision.
Pah-wraiths � the Prophets that were cast out of the Celestial Temple, into the fire caves of Bajor.
Pal - a Petraw, Kam�s aide aboard Malic�s ship during the negotiations for the Iconian Gateways.
Palmer, Lieutenant � transporter officer on the USS Enterprise-E.
paluku - a species of animal native to the Bajoran system, they are about the size of a small Terran dog, but spidery in shape. They were a source of food for the resistance fighters during the Cardassian Occupation.
Pathfinder Project, the - based San Francisco, Earth, a group of engineers and scientists attempting to make contact with the USS Voyager in the Delta Quadrant. The project was overseen by Admiral Owen Paris, with Commander Pete Hawkins as the direct supervisor. One of the engineers involved with the project was Lieutenant Reginald Barcley, who used holographic representations of the Voyager crew to help himself relax.
Patrick - genetically enhance human male, who had a child-like attitude; a part of the Jack Pack living at the Institute.
Peldor Festival - a Bajoran holiday of joy and gratitude.
Pennington School � a writing school on Earth that Jake Sisko had been accepted to, but never attended.
Perez - Europani refugee that was sharing quarters with his brother and sister, he had a complaint about the heat in his room.
Periki Remarro - Bajoran female, the first to publicly denounce the oppressive Lerrit regime and call for independence. The Lerrit government had her hung shortly after she began to voice her opinions against them.
Perikian flag, the - the flag of the Perikian Republic, it was flown beneath the Endtree flag on the Haeys.
Perikan Free Army - the army of the Perikian Republic of ancient Bajor.
Perikian Peninsula - located on Bajor, named for Periki Remarro.
Perikian Republic - an independent government, the name given to the residents of the Perikian Peninsula after the Lerrit Army was defeated and pushed back to the mainland.
Perim, Ensign � unjoined Trill conn officer onboard the USS Enterprise-E.
Phase Three - during the lower core transfer from Empok Nor to Deep Space Nine, Doctor Tarses compared this phase to a heart transplant.
phased polaron beam � the title for the Dominion�s directed energy weapons.
phaser scopes � Lieutenant Ro Laren had intercepted an illegal shipment of them, but kept it a secret from Colonel Kira Nerys. She believed that Quark would owe her a favor because of her actions.
Picard, Jean-Luc Captain � human male; commander of the USS Enterprise-E, NCC 1701-E. Also commanded the USS Stargazer and the USS Enterprise-D. During the Gateways mission, Captain Picard was placed in temporary command of the USS Marco Polo.
Picard, Maurice - deceased human male; Captain Jean-Luc Picard�s father.
pieta - a religious icon of a woman holding her dead son by the artist Michelangelo. The DellaMonica family had a replica of it since the eighteenth century, but had to leave it behind on Europa Nova.
Pirak, Gul - Cardassian military officer that was the target of an attack by the Shakaar resistance.
Plan B - during the evacuation of Europa Nova, Plan B was implemented after the transporters were taken offline. Landing sites for ships were found and refugees were transported to the ships.
Plexicons - a methane breathing race; some Plexicons had left Deep Space Nine shortly before the Europa Nova evacuation.
plomeek soup - a Vulcan dish that Doctor Bashir enjoys; Doctor Locken made his, rather than replicate the dish.
Po, Vedek � one of the Bajoran vedeks on Deep Space Nine.
polarizer - a tool used by Lieutenant Nog to align the one of the holosuites in Quark�s bar so that Colonel Kira Nerys and Commander Elias Vaughn could participate in Admiral Ross�s holoconference during the Gateways crisis.
positron scan - one of the scans performed by Ensign ch�Thane in the investigation of the lack of Iconian Gateways in the Bajoran system after the magnetron scan turned up negative.
Potemkin, USS � one of Commander Riker�s previous posts; he served as an operations lieutenant before his promotion to lieutenant commander.
Praxis - a Klingon moon, in orbit of Qo�noS at the time of it�s destruction in the mid2270s. The moon�s explosion, which was monitored by the USS Excelsior under Captain Hikaru Sulu�s command, was the cause for the Klingon Empire to seek peace with the United Federation of Planets. During the Gateways crisis, the remnants of an Iconian Gateway were found in the remains of Praxis.
prenatal exam - despite living on Bajor, Captain Kasidy Yates still traveled to Deep Space Nine so that Doctor Julian Bashir could conduct her monthly prenatal exams. When she was on the station for her fifth exam, she learned of the problem at Europa Nova, and volunteered the Xhosa.
Presley, Rear Admiral � high ranking Starfleet officer with a security clearance similar to Commander Vaughn�s; after Vaughn made his decision to join the crew on Deep Space Nine, Admiral Presley put the order through, pending Colonel Kira�s approval.
prey - the term used by the Hirogen hunters to define those that they hunt. The worthiness of the prey is determined by the rarity of the physical characteristics and the resistance posed during the hunt.
Prilla - a young girl who announced the arrival of the Bajora at the first meeting of the Perikian Republic. She also showed the Bajora envoys to a chamber where they could refresh themselves while the meeting continued.
prion weapons - missiles that carried a mutated protein sequence developed by Doctor Ethan Locken that could be transmitted through the air, in water, and through sexual contact that could infect any species with a central nervous system, turning their brains into mushy paste.
Program 06010 � a holodeck program, Life Cycle Meditation/Old Growth Forest, that Commander Vaughn hadn�t used in ten years but enjoyed during the trip from the Badlands to Deep Space Nine. The full program runs over two hours.
Promenade, the � circular section of Deep Space Nine that houses Quark�s Bar, the Klingon restaurant, the Bajoran Shrine, the Security Office, and other businesses. Consists of an upper and lower level.
Promenade Merchants� Association � the association of business leaders and merchants on Deep Space Nine�s Promenade.
Prophecy of the Avatar, the � the final prophecy in the unnamed book that called for the deaths of ten thousand people before the child of the Emissary could be born into a world of peace.
Prophets � the residents and creators of the Celestial Temple; non-linear aliens who Commander Sisko made contact with in 2368.
protectorates - outer territories of the Cardassian Union safeguarded by the Federation, the Romulan Star Empire and the Klingon Empire until the Cardassians could protect their own borders again.
protomatter - the Purists demanded weapons-grade protomatter from Lieutenant Ezri Dax as ransom for the release of Doctor Lenara Kahn.
Prylar � the lowest title for a servant in a religious order of Bajor.
Purists - Verad Kalor�s dissident faction of unjoined Trill; believed that the symbionts were aliens who had taken over the Trill.
Qapla� - Klingon term for �success�.
Qo�noS - the homeworld of the Klingon Empire, location of the Klingon High Council and the Federation Embassy. During the Gateways crisis, this was the USS Marco Polo�s first stop.
Quark � Ferengi male; resident of Deep Space Nine. Quark is the owner of Quark�s on the Promenade, and spokesman of the Promenade Merchants� Association.
Quark�s Treasure - the Ferengi shuttle Gaila sent to Quark, to repay him for the loan that started his weapons business. The shuttle was sabotaged and couldn�t drop out of warp. When Rom tried to slow the ship down on approach to Earth, Quark, Rom, Nog and Odo were transported back in time to 1947 and crashed near Roswell, New Mexico.
Queen, the - ruler of the Lerrit on ancient Bajor. Perikian spies reported that she was dying, but continued to put in appearances at official functions.
R�taga, Captain � Klingon commander who was part of the Allied task force headed for the Gamma Quadrant; was also present at Taran�atar�s debriefing in Deep Space Nine�s wardroom.
Rachel Jadzia � one of the names Kasidy Yates was considering for her unborn child.
raktajino � Klingon coffee, the favored drink of Colonel Kira Nerys.
ready room, the - Captain Picard�s office, adjoined to the bridge of the USS Enterprise-E.
Reckoning, the � a showdown between the Prophets and the Pah-wraiths that would usher Bajor into a new era. The Reckoning occurred on Deep Space Nine in 2374, between Prophet Kira Nerys and Pah-wraith Jake Sisko, but was interrupted by Kai Winn Adami.
Redlitz - Starfleet crewman assigned to the Defiant bridge in 2376.
Remeta�klan � Jem�Hadar Third, faithful to the will of the Founders and the order of things, up to his death during the first six months of the Dominion War.
remla bird - an animal native to Bajor. When the Bajora envoys arrived at the first meeting of the Perikian Republic, General Torrna asked if they were flew in by remla birds.
Renhol, Doctor - Trill female, a member of the Symbiosis Commission that Lieutenant Ezri Dax had to check-in with at least once a month. She had an angular face, and her brown hair was always severely pulled back. Doctor Renhol contacted Lieutenant Dax during the Europa Nova evacuation.
Replimat, the � a small eatery on the Promenade, which just had self-serve replicators for food and drinks and tables to eat at.
Resistance, the � the militant Bajoran freedom fighters/terrorists who fought the Cardassians during the Occupation of Bajor.
Reymer, Captain - commanding officer of the USS Destiny.
Richardson, Vice Admiral � high ranking Starfleet officer with a security clearance similar to Commander Vaughn�s; attempted to force Vaughn�s status as an independent tactical operative, which led to Vaughn threatening to retire from Starfleet.
Rigel - at the time of the massacre at New Beijing, Starfleet forces were successfully repelling a Dominion attack in the Rigel system.
Riilampe - a Kobheerian entrepreneur that was looking to buy land. Quark contacted him about purchasing some land on Chin�toka IX.
Riker, William Thomas Commander � human male; First Officer of the USS Enterprise-E, NCC 1701-E.
Riker, William Thomas � a Maqui rebel, transporter duplicate of Commander William T. Riker. Shortly after the Defiant was assigned to Deep Space Nine, Riker attempted to steal the warship and launch an attack against the Cardassian Union. To ensure the survival of his fellow Maqui, Thomas Riker surrendered himself to the Cardassian Central Command.
Rio Grande, the � one of Deep Space Nine�s assigned runabouts and has been assigned to Deep Space Nine since Starfleet took over the station in 2368. Lieutenant Nog used the Rio Grande during his mission to the Trivas system.
Risa � a pleasure planet, popular vacation spot in the Federation.
Ro Laren, Lieutenant � Bajoran female, the chief of station security for Deep Space Nine. Currently an officer in the Bajoran Militia, former Starfleet officer and Maqui rebel. Ro served as a conn officer onboard the USS Enterprise-D, and attended Starfleet�s Advance Tactical Training course.
Ro-Epsilon-Seven-Five-One - Lieutenant Ro Laren�s command authorization code.
Robison, Captain � commanding officer of the USS Aldebaran at the time of it�s destruction in 2376.
Roka - non-Trill member of the Purists. Verad killed Roka shortly after he reported the survival of the Odan symbiont.
Rom � Ferengi male; Grand Nagus of the Ferengi Alliance. A former technician for the Bajoran Militia on Deep Space Nine, he was named as Zek�s successor in late 2375, towards the end of the Dominion War. Rom is the younger brother of Quark, and Nog�s father.
Romulan Senate � the governing body of the Romulan Star Empire; agreed to allow the Defiant the continued use of a cloaking device.
Romulan Star Empire, the � an enigmatic and secretive race, an offshoot of the Vulcans.
Rondac III - a planet inside Cardassian space. When Damar began his campaign against the Dominion, the cloning facilities on Rondac III were the first targets. The Trager led the attack. Months later, the ship still bore the scars from that battle.
Roness, Ensign - female Starfleet officer who was aboard the Runabout Rio Grande with Lieutenant Bowers when the Malon escape pod came through the gateway with Taran�atar aboard.
root beer � an Earth beverage that Nog began drinking when he was accepted into Starfleet Academy.
Ross, Bill Admiral � ranking Starfleet officer near the Bajoran sector; during the war, he formed a close relationship with Captain Sisko and his senior staff. After the Jem�Hadar attack, Ross was in charge of the peacekeeping force that was to enter the Gamma Quadrant.
Rubicon, the - one of Deep Space Nine�s runabouts used in the early 2370s; crashed on a planet in the Gamma Quadrant with Doctor Julian Bashir and Chief Miles O�Brien onboard.
Runabout Pad A - the landing pad where the Runabout Euphrates was docked on Deep Space Nine before the Europa Nova evacuation.
Runabout Pad C � the landing pad where the Runabout Euphrates was docked on Deep Space Nine before the Sindorin mission.
runabouts � small, warp-capable ships assigned to Deep Space Nine; they have tractor beams, phaser arrays, and transporter pads, as well as small crew quarters in the aft compartments.
Rura Penthe - location near the edge of the Klingon Empire, a penal colony that was known as the aliens� graveyard when Captain James T. Kirk and Doctor Leonard �Bones� McCoy were sent there after the assassination of Chancellor Gorkon.


Christmas time is almost here and to help you celebrate the season in a totally far out way, look to your friends Buzz Lightyear, Mike Wazowski and everyones favorite little troublemaker you can help but love.. Stitch!
All three gather along with the vocalist and host, Haley Comet, in a wild and wacky yet adorable stage show full of song, dance and story.
The show starts off with Haley on a mission with her pal Stitch to track down Santa. As expected when Stitch is involved, things get a little mischievous. But to help tell her tale of the holidays until Santa arrives, she brings out Buzz Lightyear to tell his tale of the holidays. A heartwarming space rendition that even includes the softer size of the Evil Emperor Zurg!
For the next tale, the brains behind the Laugh Floor Mike Wazowski makes his holiday debut in full festive attire. For him, thats roughly an elf hat and shoes, but he's stylish as always none the less. His holiday song and dance is anything but frightening (maybe his singing voice might scare you slightly) as he brings to life his version of a holiday classic.
To close out the show, even though Santa may have given Stitch the slip, he makes sure that Christmas arrives for Haley by crashing the party in the most jolly of ways. Even though he's usually on the naughty list, he makes up for his badness level this year as the show's finale takes place.
In the end, all the characters join in on stage for a heartfelt and upbeat celebration of the season with a surprise at the end. You can find out the surprise by watching the video we've included. This performance runs nightly, exclusively during Mickey's Very Merry Christmas Party until mid-December. Then after all the separate ticketed parties conclude, the show is presented nightly with regular park admission from mid-December until the end of the year.