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Stanford Medicine News 03 Dissecting the evolution of drug resistance Story
Skin tumors develop specific mutations to resist drug, researchers say
Basal cell carcinomas develop mutations in a protein on the Hedgehog pathway to evade a common drug therapy. Targeting another portion of the pathway may be an effective alternative treatment.
March 9, 2015 - By Krista Conger
Anthony Oro and his team have identified mutations in cancer cells that make them resistant to a common drug therapy.
Steve Fisch
Among people with advanced basal cell carcinomas who see their skin cancers shrink or disappear in response to a common drug therapy, about 20 percent will relapse within months as the cancer cells become resistant to the treatment. The situation is frustrating to both patients and their physicians.
Now, researchers at the Stanford University School of Medicine have identified specific mutations in the cancer cells that confer resistance to the drug, vismodegib, which is sold under the brand name Erivedge. They've also shown that another class of drug, called a Gli antagonist, may be able to successfully tackle even vismodegib-resistant cancers. The finding could hasten the use of Gli antagonists in the clinic, they said.
"This research sheds new light on mechanisms of how tumors evolve to develop drug resistance, and has already helped us with personalized cancer genetics and therapy for our patients," said Anthony Oro, MD, PhD, professor of dermatology. "It is now possible for us to identify those people who may benefit from a combination therapy even before they begin treatment."
A paper describing the research findings was published March 9 in Cancer Cell. Oro; Jean Tang, MD, PhD, associate professor of dermatology; and Anne Chang, MD, assistant professor of dermatology, share senior authorship. Postdoctoral scholar Scott Atwood, PhD, and Kavita Sarin, MD, PhD, assistant professor of dermatology, share lead authorship.
Approximately 2 million new cases of basal cell carcinoma are diagnosed each year in the United States, making it the most common cancer in the country. About half of patients with advanced basal cell carcinomas will respond to vismodegib, which belongs to a class of drug compounds called Smoothened inhibitors. About 20 percent of these responders will go on to quickly develop resistance to the drug.
Basal cell carcinomas are uniquely dependent on the inappropriate activation of a cellular signaling cascade called the Hedgehog pathway. Blocking signaling along this pathway will stop the growth and spread of the cancer cells. The Hedgehog pathway plays a critical role in normal development. It's also been found to be abnormally active in many other cancers, including pancreatic, colon, lung and breast cancers, as well as in a type of brain cancer called medulloblastoma.
Signaling cascades like the Hedgehog pathway can be imagined as a line of upright dominos on the floor. Tapping one domino on the end causes a chain reaction down the line until all the dominos are toppled. In this way, signals from outside the cell are transmitted into the cell by the sequential activation of specific proteins until a particular action is accomplished.
It is now possible for us to identify those people who may benefit from a combination therapy even before they begin treatment.
Vismodegib binds to and inactivates Smoothened, or Smo, a key protein in the Hedgehog pathway. In the domino analogy, Smo is one of the first tiles in the signaling chain. In 2012, vismodegib became the first Smo inhibitor approved by the Food and Drug Administration to treat advanced and metastatic basal cell carcinoma.
Smo is one of many members of a class of proteins called G-protein-coupled receptors. These receptors sit on the surface of the cell and translate external signals across the cell membrane to control cellular processes like growth and division. However, it's possible for the protein to develop mutations that allow it to escape the inhibitors.
The researchers examined gene expression patterns in 44 vismodegib-resistant tumors from 15 patients. (Every tumor can have a distinct genetic profile.) They found that the Hedgehog pathway remained active in the resistant tumors, despite ongoing treatment with vismodegib. This indicated that the cancer cells were not switching to other cancer-associated pathways in response to therapy but were instead figuring out a way to continue to transmit the signal.
Evasive action
Oro and his colleagues then sequenced the cells' exomes, or regions in the genome that encode protein-making instructions. They found mutations in 15 of the 29 proteins in the Hedgehog pathway. Of these, Smo was the protein most often affected: It was mutated in six of the 14 tumor samples, suggesting that mutations in the protein are one of the primary ways that basal cell cancers overcome vismodegib treatment.
Upon further investigation, the researchers found two main classes of mutations in Smo that were associated with vismodegib resistance. One class included mutations in the region of the protein to which the inhibitor binds. Four mutations in this region stopped vismodegib from binding to Smo.
These are like little springs.
The second class of mutations was somewhat unexpected. "We found that there are particular amino acid residues that bind together to hold the protein in an inactive conformation," said Oro. "These are like little springs. When these amino acids are mutated, the Smo protein becomes what's called constitutively active, or always 'on' regardless of what signals it receives from upstream in the pathway." The researchers found four mutations in this region of the protein in the resistant tumors.
Finally, the researchers grew both vismodegib-resistant and -susceptible cells in the laboratory. They found that tumors with either class of mutations in the protein grew more quickly in the presence of vismodegib than did cells with unmutated Smo proteins. Furthermore, treating the cells with inhibitors that target a portion of the pathway downstream of Smo blocked the activation of the pathway even in cells with the mutations. These inhibitors, called Gli antagonists, could be an effective way to treat vismodegib-resistant tumors, the researchers said.
Plans for personalized therapies
Oro and his colleagues are now using information about mutations in Smo as a way to guide therapy decisions for their patients.
"We've just started a personalized genomics clinic at the Stanford Cancer Institute," said Oro. "Our expectation is that patients will come in, have their tumors sequenced and subsequently receive the best treatment for their types of cancer. Eventually we would like to do this for many types of skin cancers, including melanomas and squamous cell carcinomas."
Other Stanford authors are postdoctoral scholars Ramon Whitson, PhD, Jiang Li, PhD, and Mina Ally, MD; Jinah Kim, MD, assistant professor of pathology and of dermatology; technicians Geurim Kim and Melika Rezaee; and graduate student Catherine Yao.
The research was supported by the National Institutes of Health (grants 5ARO54780, 2ARO46786 and 1K99CA176847), the V Foundation, the American Skin Association and the Dermatology Foundation. Oro and Chang are investigators in clinical trials sponsored by Genentech, Novartis and Eli Lilly. Tang is a consultant for Genentech.
Information about Stanford's Department of Dermatology, which also supported the work, is available at http://dermatology.stanford.edu.
Krista Conger
Krista Conger is a senior science writer in the Office of Communications. Email her at kristac@stanford.edu.
kristac@stanford.edu
Margarita Gallardo
mjgallardo@stanford.edu
About Stanford Medicine
Stanford Medicine is an integrated academic health system comprising the Stanford School of Medicine and adult and pediatric health care delivery systems. Together, they harness the full potential of biomedicine through collaborative research, education and clinical care for patients. For more information, please visit http://mednews.stanford.edu.
Discovery opens door to multipronged attack against common skin cancer, study shows
Hailed as a major step forward in the effort to develop targeted cancer therapies, a recently approved drug for the most common type of skin cancer has been a mixed blessing for patients.
Behind cancer drug, a 30-year history of scientific breakthroughs
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A jack of all trades but a master of none. This is how many big law firms function when they attempt to tackle a broad range of practice areas and legal matters. We believe that focusing on one practice area allows us to be more proficient in handling our clients' cases. The attorneys at the Musgrove Trial Firm are personal injury specialists and we reassure you that you are in good hands.
Our personal injury lawyers understand the importance of focusing all of our energy into one area of law. That is why we ONLY practice Personal Injury law. This enables us to better understand the complex issues involved in personal injury cases, which leads to outstanding results for our clients.
We are committed to our clients' needs and we are dedicated to providing them with the best legal representation they deserve. Throughout each case, we will ensure that the needs and concerns of every client are addressed in a prompt and suitable manner.
Our lawyers are dedicated exclusively to helping injured clients receive the maximum compensation they deserve. With over 10 years of combined legal experience, we have the highest level of professionalism, ethics, and expertise to handle any type of personal injury case.


Vertical centerline treatments provide a sense of friction and can narrow lane width through the use of longitudinal channelizers.
Vertical centerline treatment (Shauna Hallmark et al./Institute for Transportation).
Vertical centerline treatments provide a sense of friction and can narrow lane width through the use of longitudinal channelizers. Depending on where channelizers are used, they may be between 18 and 36 inches tall, spaced roughly 3 feet apart, and be yellow or orange in color.
Channelizers have been used in workzones, high-occupancy vehicle (HOV) lanes, and on ramp exits. Special considerations must be taken when large trucks or farm equipment are present, because channelizers may restrict movements. Other vertical centerline treatments include use of raised pavement markings or raised curbing.
The ability of longitudinal channelizers to reduce speeds is not well documented. The majority of research regarding these devices pertains to their use at highway-railroad grade crossings.
The North Carolina DOT (NCDOT), for instance, placed the delineators along the centerline of the roadway extending about 100 feet from the railroad gates to dissuade drivers from going around the gates. Afterward, they found the delineators reduced violations by 77 percent (ATSSA 2006). Longitudinal channelizers were used to create a center median as part of a rural traffic calming project (Hallmark et al. 2007) with reductions of up to 3.0 miles per hour (mph) in mean speed and 3 mph in 85th percentile speed.
No crash modification factors (CMFs) were found relating to longitudinal channelizers.
Vertical centerline treatments are not appropriate for all situations but could be used to give drivers the perception of lane narrowing when entering a town.
Longitudinal channelizers, raised pavement markings, and temporary curbing are a low-cost option for narrowing lanes.
ATSSA. Low Cost Local Road Safety Solutions. American Traffic Safety Services Association, Fredericksburg, VA, 2006.


MusicRadar has launched SampleRadar, a new weekly giveaway of pro-quality, royalty-free samples.
We'll be offering you loops, hits and multisamples in a wide range of genres, and you won't have to pay a penny to download any of them.
Our first theme is dubstep, the much-talked-about style that features elements of garage, grime and 2-step. One of the great things about dubstep is that you don't need loads of gear to create it – in fact, many of the scene's most prominent producers make their music at home using little more than a computer and some software.
This being the case, pretty much anyone can try their hand at dubstep, but to give you a leg-up, MusicRadar is offering you 342 royalty-free samples for nothing.


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Каплиця святої мучениці Тетяни — православна (ПЦУ) каплиця у Шацьку на Волині.

Історія побудови каплиці
22 вересня 2006 року на території Шацького лісового коледжу ім. В. В. Сулька було освячено Хрест і закладено наріжний камінь під будівництво каплиці Мучениці Тетяни УПЦ КП. А вже 8 жовтня 2009 храм для майбутніх фахівців лісового господарства було освячено. Каплицю зведено за кошти цього навчального закладу (директор Ігор Жмурко), обласного управління лісового і мисливського господарства (начальник Богдан Колісник), власника готелю-ресторану «Водограй» у Шацьку Георгія Курагеу.

Джерела
 Стаття "У Шацьку збудують каплицю мучениці Тетяни" за 22.09.2006 з офіційного сайту Волинської єпархії Української Православної Церкви Київського Патріархату
 Стаття "Каплиця для лісівників"  за 08.10.2009 з офіційного сайту Волинської єпархії Української Православної Церкви Київського Патріархату

Каплиці України
Церкви Шацька
Церкви Волинської єпархії ПЦУ
Культові споруди, побудовані 2009

redpajama_set_name: RedPajamaWikipedia


To those old enough to remember the eponymous SNES video game classic, the simple name of The Pilotwings will undoubtedly evoke happy memories. A playful, fun-driven duo from Lyon, Guillaume Lespinasse and Louis De La Gorce first emerged in 2014, making quite a splash with their quickly sold-out debut 12″, 'Agorespace', which also marked the beginning of the adventure for BFDM. Melding muscular breaks, faux-balearic house melodies, pot-fuelled dub and reshuffled trancey accents, the pair's inaugural outing quite clearly outlined the contours of their pieces to come. Followed by a solid second EP in 2015, and no less than two high-rated albums for BFDM and Macadam Mambo one year later, 'Les Portes Du Brionnais' and 'Une Nuit Au Boxboys', and another EP in 2018, Guillaume and Louis cemented their status as one of France's most refreshingly genuine and talented new groups to cycle through European stages in recent times.
Also active as Jonquera (Guillaume), Eiger Drums Propaganda and Mortimer Du Baton (Louis), The Pilotwings have forged a new live set that lives up to their high-flying studio standards, further exposing their love for deep house, Eurasian synth-pop, electronic library, exotica, retro video game soundtracks and – yes – eurotrance, through colourful musical cocktails. Joined on stage by fellow BFDM family member Lastrack on guitar, the result is a performance that slams down the frontiers between genres and tempi, showcasing the duo's unparalleled capacity at incorporating all types of aesthetics to make it theirs. Meditative and dancy, intuitive yet carefully mastered, Louis and Guillaume's music shines in its propensity to conjure up vibrant atmospheres where textural luxuriance and unrestrained electronic friskiness reign supreme. Time to stick a smile upon these sad faces, The Pilotwings are at the helm. Who can top that ?


I have been a Motorcycle Instructor since 1994 and learned my trade the proper way through serving an apprenticeship so to speak. CBT1 and DAS qualified through Cardington Assessment. I am constantly looking for ways to improve both my riding and instructing skills. I qualified in 2005 as a Diamond Advanced Riding Instructor and Examiner and I hold a Certificate of Professional Competence for the Road Transport Industry.I am qualified to teach CBT, CBT Plus, DAS, Bike Plus and Advanced to Diamond standard.
Paul joined ATB in 2004 as a part time CBT Instructor, and then never left. He mainly provides CBT Training along with pre-course training, 125cc road rides and Restricted Licence, Paul is fully qualified to teach all levels of motorcycling including Direct AccessTraining. He makes the learning process fun but ensures that you understand the very serious nature of the training required to develop the skills necessary to ride a motorcycle well.
As Senior Instructor I learned my trade through the apprenticeship method, via CBTs, Cardington Assessment and then Cardington DAS qualification. Qualified to Advanced riding standards in 2007. I deliver a first class, flexible but fun approach to instructing - and pride myself in the quality of riders having passed their tests with my help. I am qualified as an Instructor for CBT, CBT Plus, DAS, Bike Plus and Advanced to IAM Standards.
Here is another description of the team member.
Thankyou for all your patience, it's been brill! I've loved every minute of it and you are all fab!
Big thankyou to everyone at ATB. Great teaching and has been a pleasure to learn to ride here. Will definitely recommend to others in the future. Cheers!
Well what can I say? Thanks for all your help, it's not been easy for both parts, mine and yours! First class teaching, thanks Richard, Jon, Nigel and Paul - you will be recommended!
Thankyou very much to all at ATB, a great bunch of lads. You came highly recommended and I will ensure anyone interested is sent your way.
Great team at ATB, made me more confident as well as drilling out old habits! Had great fun, and will stay in contact. Will definitely recommend you. 5 Star team!
This is a No:1 outfit in our region with far more experienced instructors. The attention to detail, the feedback and the friendliness of the of the whole team is a winning combination. Every step you take as a student is progressive but within your capabilities and they have the knack of building self- confidence in anyone. My time with ATB has been a great experience and they shared in my joy at getting my full licence with genuine delight. This is a group of guys i will stay in touch with and will always be grateful for the achievement they played such a massive part in. Well done Nigel and co.
We offer a wide range of motorbike training course, yet we are alway willing to customise something to your needs. Contact us and let us know what you want today.


A no show is treated as a cancellation and the total for the first night of the reservation will be charged.
Guests under the age of 16 years old need to be with their parents / guardians.
No stag or hen parties (bachelor or bachelorette).
BEDANDBE is a TOP RATED Hostel on José Cruz Conde, main commercial street in Cordoba city center. It is the Lonely Planet selection and top rated hostel in TripAdvisor works as a hostel/bed&breakfast, new, clean and complete, ...with local hosts, bicycles on the ground floor, a roof terrace and beautiful attic on the top floor. Free bike/walking night tapas tour, the walking tours, Sushi dinners, BBqs are some of the daily activities at the hostel!
It is a charming place with 10 bedrooms: twins, 4 and a 8 beds dorms, (both with individual lockers). All rooms have big windows or balcony and their own AC. There is also a lounge with a big Tv, sofas, arm chairs,dinning tables, even a rocking chair.The high ceilings and the many tall windows that are west-facing and look out onto the promenade, make the hostel feel very light and peaceful.
We have also incorporated all the comforts of modern life too, like: air conditioning, WIFI, Led TV, and all types of appliances (dishwasher, washing machine, dryer, induction kitchen, microwave fridge and freezer, coffee maker, kettle, toaster) in a fully equipped kitchens, and 7 spotless bathrooms.
The hostel is placed on the downtown of the city. From foot you can easily access all the city main sights. The staff was excellent, very nice and attentive. The showers, as well as the lockers, are good. It's a great place, and I'm sure I'd return if I have a chance.
A localização é boa, fica entre a região turística, a parte comercial da cidade e a estação de trem. O ambiente é alegre e agradável. Os quartos são muito bons e confortáveis, e a equipe foi super atenciosa e me deu várias dicas sobre a cidade. Voltaria a me hospedar aqui!
Em nossa estadia de duas semanas na Andalucia este foi o melhor Hostel. Não apenas pelo ambiente e localização, mas especialmente pelo tratamento da equipe e simplicidade da organização.
Best location, best staff and best hostel in the city.
Very friendly staff, clean installations, good A.C. and good shower. Not a party hostel but easy to meet new people. Very welcoming atmosphere that make you feel you are home.
Hostel mais bem cuidado que já fiquei. Tudo muito limpo e bem arrumado. Duas cozinhas à disposição, terraço e sangria grátis à noite. Único ponto é que tem poucos banheiros, se o hostel estiver cheio pode ser um problema.
A equipe do hostel são as pessoas mais amáveis que você poderia conhecer, super atenciosos! O mapinha da cidade é super legal e com boas dicas. Todos os dias tem saída para tapas às 20:30, super recomendo! O café da manhã também é super gostoso, você pode fazer seu próprio suco de laranja. Mas venha com poucas malas, porque o prédio é antigo e não tem elevador, e o espaço dos quartos é limitado.
Muito caro para o que é oferecido. Café da manhã pífio. Não há elevadores e me colocaram no alto. Não recomendo.


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John Oliver (HBO)
John Oliver rips CNN for mistaking pride parade flag for ISIS flag: You work at CNN -- and you don't know what a dildo looks like?
CNN's royal "f-up" this weekend is sure to go down in history right alongside SCOTUS' same-sex marriage ruling
June 29, 2015 5:43PM (UTC)
CNN's royal "f-up" this weekend is sure to go down in history -- some type of special history -- right alongside SCOTUS' historic same-sex ruling.
In a live segment following Saturday's gay pride parade in London, CNN reporter Lucy Pawle claimed that she'd seen an ISIS flag when, in fact, the flag was actually decorated with dildos and butt-plugs.
"I seem to be the only person that's spotted this, and nobody seems to be raising any questions or pointing it!" she was heard saying in the seven-minute segment which featured a prominent banner reading "ISIS FLAG SPOTTED AT GAY PRIDE PARADE."
CNN quickly washed their hands clean of the egregious error and took down the video from the Internet. But thankfully, because people like "Last Week Tonight's" John Oliver exist, it lives on forever.
The host took a minute of his program Sunday to revisit the weekend highlight, leading into the segment: "The award for greatest moment in global Pride celebrations actually had nothing to do with gay marriage, and everything to do with the idiocy of CNN."
Oliver, who jumped on the story a full 24 hours later, was shocked to learn that CNN hadn't issued any sort of apology or retraction for the blunder.
"Probably because it would be too embarrassing to have a professional journalist say, 'I'm sorry. Despite working at CNN, it seems I don't know what a dildo looks like,'" he concluded.
Watch the clip of the original segment, followed by Oliver's takedown below:
Cnn John Oliver Last Wee Tonight Video
Check out this article! https://www.salon.com2015/06/29/john_oliver_rips_cnn_for_mistaking_pride_parade_flag_for_isis_flag_you_work_at_cnn_and_you_dont_know_what_a_dildo_looks_like/

redpajama_set_name: RedPajamaCommonCrawl


These are great educational resources.
This curriculum is very teacher intensive but it will inspire your child to read and write beyond all expectations.
This spelling curriculum is very interactive and is rule based.
The Singapore math curriculum gives your student a foundation in mental math and modeling in word problems. The Biology Matters is good for conceptual learning.
I was half asleep until about lesson 50 when I realized my little girl was reading!
We listen to the MP3s. My children can't get enough of this.
We also listen to this one on Audible by Amazon. It roughly covers God's creation classifying each under the five kingdoms.


A growing number of Mojahedin-e Khalq Organization (MKO) members are leaving the terrorist group as MKO ringleaders are busy with a compulsory relocation from the Northern Diyala province to a Baghdad camp where they are sheltered transiently before being expelled from Iraq, reports said on Tuesday.
A report by the Persian-language Neday-e Haqiqat (the Voice of Truth) website said that another MKO member took the opportunity provided by the group's relocation from Camp Ashraf in Northern Iraq to Camp Liberty and escaped on Monday.
Alireza Khamoushi, the ninth MKO member to flee the group in just the last one month, had been imprisoned and tortured before fleeing the camp.
The defected members describe improper psychological conditions and strict cult rules and restrictions as their main reason for fleeing the terrorist group.
Some defected members of the group had earlier unveiled that MKO ringleaders are using every means within their reach, including execution, to prevent the members' defection from the group.
The defected members revealed that the main ringleader of the group, Maryam Rajavi, issues the execution orders personally and condemns to death all the dissidents who refrain from obeying her orders and all those who plan to defect from the MKO.
According to the report, the MKO ringleaders have prevented the members of the group from meeting their relatives for the last two years in a bid to prevent their defection and escape from the camp.
Also in March 2011, another defected member of the MKO revealed that the female members of the group have been living under captivity for more than 25 years and are not even allowed to appear in public places alone.
"It can be firmly said that 95% of the women in Ashraf Camp (the terrorist group's resort in Iraq) have not even been allowed to step in Iraq's public and recreational places alone all throughout the last 25 years," the defected member said.
The former member of the MKO also revealed that nearly 70% of the female members of the terrorist group are single and have not been allowed to marry anyone in or outside the group.
And only a total 10% of the married members have been allowed to have children, he added.
Many of the MKO members abandoned the terrorist organization while most of those still remaining in the camp are said to be willing to quit but are under pressure and torture not to do so.
The most shocking of such stories includes accounts given by former British MKO member Ann Singleton and Mustafa Mohammadi - the father of an Iranian-Canadian girl who was drawn into the group during an MKO recruitment campaign in Canada.
He also explains how the group forces the families of its recruits to take part in pro-MKO demonstrations in Western countries by threatening to kill their loved ones.
Ali Safavi, a senior member of the MEK's political wing, the National Council of Resistance in Iran (NCRI), coached witnesses before and during the hearing. The NCRI is designated as a terrorist affiliate of the MEK.
Washington, DC - Congressional supporters of the drive to remove the Mujahedin-e Khalq (MEK) from the U.S. terrorism list defended the organization's use of violence while dismissing Iran's nonviolent Green Movement at a hearing on Capitol Hill last week. The hearing was also remarkable in that senior leaders of the designated foreign terrorist organization were caught counseling some of the witnesses before the hearing. It is illegal to coordinate with a foreign terrorist organization to advocate on behalf of the terrorist group.
Despite the terrorist listing, Ali Safavi, a senior member of the National Council of Resistance of Iran, was at the hearing, where he openly counseled witnesses before and during their testimony. The NCRI is the MEK's political wing and is considered a terrorist organization by the U.S. government.
The hearing's witnesses included three former U.S. officials who have actively participated in pro-MEK conferences, including former Bush Administration Attorney General Michael Mukasey.
All three witnesses who previously appeared at MEK conferences unanimously called for the MEK to be removed from the terror list, though none were asked to disclose whether they had received money to support the organization, as have other officials who have advocated for delisting the group.
The lone dissenting voice among the witnesses, former Obama Administration advisor Ray Takeyh, was subjected to an intense back and forth with Representatives on the panel.
Takeyh warned panelists who viewed MEK as a viable alternative to the Iranian regime that the organization has no support in Iran.
Filner laughed off evidence that MEK President Maryam Rajavi is a cult leader, despite reports from the State Department and FBI of "cult-like" practices by MEK that include indoctrination rituals and torture. "She is as intelligent, humorous, humane and humble as anyone I've ever met," Filner observed, recounting what he said have been numerous meetings he has held in Paris with Rajavi.
Filner accused Takeyh of justifying violence against the MEK by highlighting the group's history of terrorism, and said the U.S. should be supporting the organization as a "third way" alternative in Iran because it opposes the Iranian regime.
Mukasey, in addition to calling for the MEK to be removed from the terrorism list, urged that MEK members be allowed to resettle in the United States. Mukasey acknowledged that members of terrorist organizations are legally barred from entering the U.S., and suggested legislation be introduced to change the law for MEK members.
Prior to the hearing, Mukasey was witnessed receiving coaching from Alireza Jafarzadeh, who served as the official spokesman for the NCRI before it was declared a terrorist group and its offices raided by the FBI in 2003.


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Home » Editor's Choice » Great Salute to a Courageous Mother
Great Salute to a Courageous Mother
Susana Tarimaco's story is an inspiration to millions of mothers around the world. Her tell of bravery motivates others to take up similiar courageous endeavours.
Photo Courtesy: FundacionMariadelosAngeles
A high profile case where a 57 year old mother has been searching her young daughter Marita de los Angeles Veron for the last 10 years and has even undertaken country wide public awareness campaign against sex traffickers and brothel owners who abducted and forced teenagers and young women into prostitution.
Susana Tarimaco, a resident of Tucuman in Argentina fanatically searched for her daughter Marita a mother of three year old daughter did not return home while visiting a nearby doctor on April 13,2002. Informed from various sources including eye witnesses that their daughter might be sold to brothel in La Rioja, a small town, she and her husband Daniel insisted police to take action against brothel owners. Initially reluctant, police raided a bar in La Rioja but Marita was not found. Not deterred by the outcome, Susana visited every bar and brothel across the country posing as a prostitute to find her missing daughter.
She has even sacrificed her personal life also. Her husband Daniel separated from her, fed up with her obsession to find Marita. Police even discouraged her to visit La Rioja as Marita was last located there. Subsequently, media got interested into the matter and took her interviews. Media pressure compelled police to step up raids on bars and brothels. During raids several girls were rescued. Bar owners and sex traffickers even tried to eliminate her on several occasions. After such incidents police protection was arranged for Susana. Meanwhile, anti sex trafficking rallies were organized in the town of La Rioja on regular basis.
In 2007, Susana was awarded an International Women of Courage Award for her initiative to curb sex trafficking. Though her daughter has not been found, despite massive search, she set up a foundation in Marita's name to rescue and help victims of sex trafficking and lobbying country's lawmakers to pass a law that would treat human trafficking a Federal (Center) subject and safeguard the future of victims.
Due to Trimarco's hard work to find her daughter, human trafficking has gained public and government attention in Argentina and government is taking some stringent measures survivors to curb human trafficking.
But for her, courage means Strength, braveness and commitment.
CategoriesEditor's Choice Tags.Susana Tarimaco, Argentian Government, Human Trafficking, International Women of Courage Award, Marita de los Angeles, Tucuman, Women Trafficking
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See what the press say.
for good behaviour, achievement or as a reward for attendance.
They are not only fun days, but also build Confidence and Self Esteem.
A magic assembly (15 minute magic show) at the beginning of the day for the whole school.
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Govt strives to make India one of the top two digital economies in the world: Mos IT
New Delhi: The primary objective of the government is to make the country a trillion-dollar digital economy and at least one of the top two digital economies in the world, Minister of State for Electronics and IT Rajeev Chandrasekhar said today.
He said that there will be a focus to intensify digitalization of government services and forming laws that are of global standards that will clear ambiguities and result in inclusive development.
"Primary objective is to make sure that our digital economy is a trillion-dollar economy-the largest in the world. If not the largest then at least one of the top 2 digital economies in the world," Chandrasekhar said while summarising the broad objective of the government for the next 25 years. He was speaking at the week-long Azadi ka Digital Mahotsav. The government has been aspiring to make India a $1-trillion digital economy by 2025.
"We want to create global sin standard laws in this country. We want to move from ambiguity or administrative discretion to a regime where global standard laws can create inclusion. It can ensure that the internet and technologies remain open, safe, and trusted, accessible to main stakeholders of the technology which are citizens of this country, Chandrasekhar said
He said there is a need to intensify the smart architecture driving digitalization of government services. "We will have a broad, clear architecture for digital governance, the minister said.
He said that there has to be a clear focus on certain areas of high technology "We will be leaders at emerging technologies, artificial intelligence, blockchain, quantum computing, high-performance computing, cyber security where the focus is on emerging technologies. We must lead the world in these technologies," Chandrasekhar said.
Electronics and IT Secretary Ajay Prakash Swahney said that there is still a lot of work left to be done in making government services universally accessible.
He said that there is a need to reach every nook and corner of the country to provide government services and explained the concept of a single sign.
"A single sign-on which helps anyone in India to be able to enter the virtual space and be able to avail all kinds of services. Sawhney said.
Source- PTI
Manipur creates 1 lakh jobs in the MSME sector: Manipur CM
New business premium is likely to grow 14% to Rs. 3.18 lakh Cr in FY22
FPIs invests a net amount of Rs. 3,117 cr
An intriguing insight onto The Brew Story
Oilmeals exports in India declining in terms of global market: SEA
HDFC bank logs a YoY net profit of Rs. 18.1% for Q3FY22
Lenders in India's equity market expects strong growth for Q3FY22: HDFC Securities
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Home » Student & School Support » School & Student Safety » Internet Safety in Schools » Acceptable Internet Use Policy
Student & School Support. You are here.
Safety & Crisis Management
Division & School Safety
Information on this page is provided by the Department of Learning.
Internet Safety in Schools
Acceptable Internet Use Policy
Virginia K-12 educators and students use instructional resources via LAN, WAN, the Internet, wireless and other electronic devices. Administrators, teachers, library media specialists, and students must monitor the use of technologies for grade-level and content appropriateness, ethics, and safety.
Schools and divisions are required to establish guidelines for appropriate technology use. These guidelines generally are called acceptable use policies (AUP). By definition, an AUP is a written agreement signed by students, their parents/caregivers, and their teachers. It outlines the terms and conditions for using technology-based devices maintained by schools and personal technology-based devices used during school hours on school property.
Legislation approved by the 2006 General Assembly and signed by Governor Kaine requires that each division's policy include an Internet safety component. You can find several resources regarding Internet safety guidelines and resources on the Internet Safety page.
An AUP must address (1) access to and transmission of data and information within the K-12 environment and (2) any technology-based device in the school or personal device brought into the school. It must include the following components:
Description of the instructional philosophies and strategies to be supported by Internet access in schools
Statement on the educational uses and advantages of the Internet in a school or division
Statement that the AUP complies with state and federal telecommunication codes, laws, and regulations
Statement regarding the need to comply with fair-use laws and other copyright regulations while accessing and utilizing the Internet and other network materials and resources
Disclaimer absolving the school division, under specific circumstances, from responsibility
List of the roles and responsibilities of division personnel, community stakeholders, parents, and students for using the Internet and other electronic-based resources
Description of the safety measures currently in place and those measures planned for emerging technologies not currently deployed in the system
Description of the methods by which the division ensures data and network security
Description of prohibited forms of technology-based applications and hardware use by employees and students in addition to details of associated penalties (including clear definitions of acceptable online behavior and access privileges—reflecting any circumstances unique to a specific school or division)
Description of the procedures to address breaches of Internet and intranet security and safety, including legal actions to be taken
Description of the ongoing professional development opportunities for each stakeholder group and associated needs assessments and evaluations
Description of the community outreach activities and associated needs assessments and evaluations
Description of the procedures for evaluating and revising the AUP
Signature form for teachers, parents, and students indicating their intentions to abide by the AUP
A regularly updated list of resources is available at delicious.com/vdoeinternetsafety
Various laws mandate Internet filtering on school and library computers. Legislation passed by the Virginia General Assembly required state schools to implement filtering in public schools by July 1, 2001. The Children's Internet Protection Act (CIPA), passed by Congress in December 2000, applies to all schools and libraries that receive E-rate discounts for Internet access and internal connections. On April 5, 2001, the Federal Communications Commission (FCC) issued regulations for schools and libraries receiving non-telecommunications E-rate discounts which were updated in 2011.
The following links provide additional information about filtering options:
2013 Internet Filter Report – TopTenREVIEWS
The ALA CIPA page – American Library Association


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Home > News > Europe boosts electric vehicles in Spain with EUR 3 billion
Dec 20, 2021 | eMobility, Mobility, News
Brussels has given the green light to one of the largest electromobility investments of recent years. On 9 December, the spanish government announced that the Strategic Project for the Economic Recovery and Transformation of Electric and Connected Vehicles (PERTE_VEC) was approved by the European Commission, which considered it proportionate to Spain's needs, particularly because of how it will contribute to the recovery of the country's automotive sector.
The plan will receive EUR 3 billion of Next Generation EU funds, although the government expects this measure to generate over EUR 24 billion in the period from 2021 to 2023, adding both public and private investments.
Increasing charging infrastructure to 110,000 facilities
It is estimated that the plan could offer a highly significant boost to the electric vehicle industry in Spain, as it is expected to expand charging infrastructure with up to 110,000 charging points in the country by 2023. In terms of vehicles, 250,000 all-electric registrations are expected within the same period, allowing electromobility to definitively take off in Spain. The measure could also result in 140,000 jobs in the automotive sector, and its contribution to Spain's GDP would be between 1% and 1.7% of the country's total.
The automotive industry is one of the most important economic sectors in Spain, not only in terms of jobs, but also because it is one of the main contributors to the trade balance. In fact, Spain is the second largest vehicle manufacturer in Europe and it ranks ninth worldwide. Overall, it represents 11% of total industry turnover, and is the fourth largest export sector, with 15% of total exports abroad.
A "necessary" commitment
The European Commission deemed the project put forward by the Ministry of Industry, Trade and Tourism a necessary commitment to facilitate investments in R&D and in environmental protection measures in the supply chain for electric and connected vehicles. "The project will help develop the electric vehicle chain and play an important role in the green and digital recovery of the Spanish economy," said Commission Vice-President, Margrethe Vestager.
The Spanish Minister of Industry, Trade and Tourism, María Reyes Maroto, said that "this project is a historic opportunity to turn the manufacturer of electric and connected vehicles into a driving project that strengthens the automotive industry throughout the country." She also stressed that "we have the industrial capacities and the leadership of companies to invest in the mobility of the future that will be more sustainable, digital, connected and safe."
Public investment in the PERTE_VEC, approved in December, is complemented with grants from the MOVES Plan, the MOVES Programme for Unique Projects, the CDTI's sustainable mobility technology programme, artificial technology and connected vehicles, amounting to EUR 4.3 billion. According to the Spanish government, this is a boost that could result in a total investment of EUR 24 billion.


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The Fred & Pamela Buffett Cancer Center project is designed to shape cancer care, research and education in Nebraska, the region and the world.
The Fred & Pamela Buffett Cancer Center project is designed to shape cancer care, research and education in Nebraska, the region and the world. Through collaboration between The University of Nebraska Medical Center and its hospital partner, The Nebraska Medical Center, patients will experience personalized care – based on the latest scientific research – in one facility. The Ambulatory care strategy is based on our vision of a system that will navigate patients through their health care journey with greater focus on wellness and disease prevention and with support throughout the entire continuum of care. This means each patient receives the right care, in the right place, at the right time, with the right quality and at the right cost.


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Home Books Maingot's Abdominal Operations, 12e
Chapter 9. Intestinal Stomas
Ira J. Kodner; Thomas E. Read; Donna L. Loehner
Kodner IJ, Read TE, Loehner DL. Kodner I.J., & Read T.E., & Loehner D.L. Kodner, Ira J., et al.Chapter 9. Intestinal Stomas. In: Zinner MJ, Ashley SW. Zinner M.J., & Ashley S.W.(Eds.),Eds. Michael J. Zinner, and Stanley W. Ashley.eds. Maingot's Abdominal Operations, 12e . McGraw-Hill; Accessed January 16, 2021. https://accesssurgery.mhmedical.com/content.aspx?bookid=531&sectionid=41808786
Kodner IJ, Read TE, Loehner DL. Kodner I.J., & Read T.E., & Loehner D.L. Kodner, Ira J., et al. (2013). Chapter 9. intestinal stomas. Zinner MJ, Ashley SW. Zinner M.J., & Ashley S.W.(Eds.),Eds. Michael J. Zinner, and Stanley W. Ashley. Maingot's Abdominal Operations, 12e . McGraw-Hill. https://accesssurgery.mhmedical.com/content.aspx?bookid=531&sectionid=41808786
Kodner IJ, Read TE, Loehner DL. Kodner I.J., & Read T.E., & Loehner D.L. Kodner, Ira J., et al. "Chapter 9. Intestinal Stomas." Maingot's Abdominal Operations, 12e Zinner MJ, Ashley SW. Zinner M.J., & Ashley S.W.(Eds.),Eds. Michael J. Zinner, and Stanley W. Ashley. McGraw-Hill, 2013, https://accesssurgery.mhmedical.com/content.aspx?bookid=531&sectionid=41808786.
Intestinal Stomas: Introduction
Continent Ileostomy
Urinary Conduit
Intestinal Fistula
Laparoscopic Creation of Intestinal Stomas
An intestinal stoma is an opening of the intestinal or urinary tract onto the abdominal wall, constructed surgically or appearing inadvertently. A colostomy is a connection of the colon to the skin of the abdominal wall. An ileostomy involves exteriorization of the ileum on the abdominal skin. In rare instances, the proximal small bowel may be exteriorized as a jejunostomy. A urinary conduit involves a stoma on the abdominal wall that serves to convey urine to an appliance placed on the skin. The conduit may consist of an intestinal segment, or in some cases a direct implantation of the ureter, or even the bladder, on the abdominal wall.
Information about the types and numbers of stomas constructed, complications of stomas, and resultant impairment of an individual's life has been limited because the diseases for which stomas are constructed are not mandated as reportable in the United States. Therefore, the United Ostomy Association of America (UOAA, www.uoaa.org), formerly the United Ostomy Association, a voluntary group of 40,000 members with stomas of various types, undertook the mission of collecting data from patients in the United States and Canada who have an intestinal stoma. A review of 15,000 such entries shows the peak incidence for ileostomy construction owing to ulcerative colitis to occur in persons between 20 and 40 years of age, with a lower peak but in the same age range for patients with Crohn's disease. The second largest peak represents colostomies constructed because of colorectal cancer, and this peak is in patients 60–80 years of age. When complications were analyzed according to original indication for surgery, we found that many patients knew that they had complications but were not aware of the exact nature of the complication. Postoperative intestinal obstruction occurred in all categories of disease, as did retraction of the stoma and abscess formation. There was a preponderance of hernia formation in patients who had surgery for colorectal cancer, whereas abscess, fistula, and stricture formation were the major complications in the patients with Crohn's disease. As new surgical procedures are devised, a justification for their utilization is often the reduction of the level of handicap that exists among patients who have had construction of a conventional ostomy. The UOA survey revealed that patients resumed household activities 90% of the time, vocational activities 73% of the time, social activities 92% of the time, and sexual activities 70% of the time. It is taken into account that patients who have proctectomy for cancer frequently lose their sexual function because of autonomic denervation and not because of the presence of a stoma.
Changes that have improved the quality of life of the patient with a stoma include the development and availability of improved stoma equipment. Specialized surgical techniques, some of which are described in this chapter, have been developed that facilitate the subsequent maintenance of an ostomy. In addition, specialized nursing techniques applied both preoperatively and postoperatively have enhanced the care of the ...


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Kulbhushan Jadhav (Source: ANI)
Kulbhushan Jadhav Case Verdict On July 17
PTI@PTI_News
Jul 04 2019, 3:53 PM Jul 04 2019, 4:40 PM July 04 2019, 3:53 PM July 04 2019, 4:40 PM
The International Court of Justice will pronounce judgment on Kulbhushan Jadhav on July 17, according to the international court's website. Jadhav is on a death row in Pakistan. The sentence will be pronounced by the court's President Judge Abdulqawi Ahmed Yusuf, the website said.
Jadhav was a retired Indian Navy officer who was sentenced to death by a Pakistani military court on charges of espionage and terrorism in April 2017. India approached the ICJ in May 2017 against Pakistan for denying consular access to Jadhav.
India had also challenged the "farcical trial" by the military court of Pakistan against 48-year-old Jadhav. The ICJ on May 18, 2017 had restrained Pakistan from executing Jadhav till adjudication of the case.
The world court held a four-day public hearing in the case in February during which both India and Pakistan submitted their detailed pleas and responses.
India based its case on two broad issues —breach of Vienna Convention on consular access and the process of resolution.
India also urged the ICJ to annul Jadhav's death sentence and order his immediate release, saying the verdict by a Pakistani military court based on a "farcical case" and it failed to satisfy even the minimum standards of due process.
Pakistan on its part insisted that the Indian Navy officer was a "spy" and not a businessman.
Pakistan claims that its security forces arrested Jadhav from restive Balochistan province on March 3, 2016 after he reportedly entered from Iran
However, India maintains that Jadhav was kidnapped from Iran where he had business interests after retiring from the Navy. Jadhav's sentencing had evoked a sharp reaction in India
Pakistan had rejected India's plea for consular access to Jadhav at the ICJ, claiming that New Delhi wants to get the information gathered by its "spy".
However, Pakistan facilitated a meeting of Jadhav with his mother and wife in Islamabad on Dec. 25, 2017.
When asked whether the verdict in the case will be announced this month, MEA Spokesperson Raveesh Kumar said the date has to be announced by the ICJ.
Follow All The Political News In India On BloombergQuint


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Trout, Horace I. January 25, 1923.
Trout, Horace I. The Breckenridge Daily American (Breckenridge, Tex.), Vol. 3, No. 178, Ed. 1, Thursday, January 25, 1923, newspaper, January 25, 1923; Breckenridge, Texas. (https://texashistory.unt.edu/ark:/67531/metapth69361/: accessed April 22, 2019), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting Breckenridge Public Library.


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Boundaries of loop domains (insulators): Determinants of chromosome form and function in multicellular eukaryotes
Darya Chetverina, Miki Fujioka, Maksim Erokhin, Pavel Georgiev, James B. Jaynes, Paul Schedl
Chromosomes in multicellular animals are subdivided into a series of looped domains. In addition to being the underlying principle for organizing the chromatin fiber, looping is critical for processes ranging from gene regulation to recombination and repair. The subdivision of chromosomes into looped domains depends upon a special class of architectural elements called boundaries or insulators. These elements are distributed throughout the genome and are ubiquitous building blocks of chromosomes. In this review, we focus on features of boundaries that are critical in determining the topology of the looped domains and their genetic properties. We highlight the properties of fly boundaries that are likely to have an important bearing on the organization of looped domains in vertebrates, and discuss the functional consequences of the observed similarities and differences.
BioEssays
https://doi.org/10.1002/bies.201600233
chromosome architecture
gene regulation
loop topology
looped domain
10.1002/bies.201600233
Dive into the research topics of 'Boundaries of loop domains (insulators): Determinants of chromosome form and function in multicellular eukaryotes'. Together they form a unique fingerprint.
Bearing Chemical Compounds 100%
Nonconductor Chemical Compounds 98%
Insulator Elements Medicine & Life Sciences 94%
Eukaryota Medicine & Life Sciences 91%
Chromosomes Medicine & Life Sciences 70%
Block Like Crystal Chemical Compounds 59%
Fiber Chemical Compounds 56%
Recombinational DNA Repair Medicine & Life Sciences 38%
Chetverina, D., Fujioka, M., Erokhin, M., Georgiev, P., Jaynes, J. B., & Schedl, P. (2017). Boundaries of loop domains (insulators): Determinants of chromosome form and function in multicellular eukaryotes. BioEssays, 39(3), [1600233]. https://doi.org/10.1002/bies.201600233
Chetverina, Darya ; Fujioka, Miki ; Erokhin, Maksim ; Georgiev, Pavel ; Jaynes, James B. ; Schedl, Paul. / Boundaries of loop domains (insulators) : Determinants of chromosome form and function in multicellular eukaryotes. In: BioEssays. 2017 ; Vol. 39, No. 3.
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Boundaries of loop domains (insulators) : Determinants of chromosome form and function in multicellular eukaryotes. / Chetverina, Darya; Fujioka, Miki; Erokhin, Maksim; Georgiev, Pavel; Jaynes, James B.; Schedl, Paul.
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Clarity Enterprises is to be found in Secunderabad, Telangana, India. In case you're trying to locate ceramics, then Clarity Enterprises is a perfect selection. A firm like this, involved in ceramics, is not uncommon to be rooted in Telangana. Displays is an added thing this establishment deals with. Extra examples of products in their extent include projectors and steel. Yet further goods you can obtain from Clarity Enterprises are screens, portable projectors, modular drawers and writing boards.


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Harvard Book Store welcomes philosopher and cognitive scientist ALVA NOË for a discussion of his book Strange Tools: Art and Human Nature.
In his new book, Strange Tools: Art and Human Nature, Alva Noë raises a number of profound questions: What is art? Why do we value art as we do? What does art reveal about our nature? Drawing on philosophy, art history, and cognitive science, and making provocative use of examples from all three of these fields, Noë offers new answers to such questions. He also shows why recent efforts to frame questions about art in terms of neuroscience and evolutionary biology alone have been and will continue to be unsuccessful.
Alva Noë is a professor of philosophy at the University of California, Berkeley, where he also serves as a member of the Institute for Cognitive and Brain Sciences and the Center for New Media. A graduate of Columbia College, he holds a BPhil from the University of Oxford and a PhD from Harvard University. The focus of his work in recent years has been on the nature of mind and human experience, with particular emphasis on perception and consciousness. In addition, he is a weekly contributor to National Public Radio's science blog 13.7: Cosmos and Culture.


The Katong Shopping Centre in Singapore is located on Mountbatten Road. The shopping centre has been in operation since 1973 and is staple to all Singaporeans who love to shop. The centre was designed in a unique way, which has helped to stand the test of time over some of the other younger shopping centres that have been built.
History of Katong is extensive and quite wonderful. It was the first chopping centre to be built in Singapore with air conditioned rooms hence making it one of the most popular shopping centre. The centre itself has everything that you could ever need to visit, making it a one-stop shop for anyone who needs to do many different errands in a day. This is so much more convenient than needing to drive all over the place to get a list of errands taken care of.
It holds several different kinds of shops and offices that anyone can visit and look around for anything that they may want or need. The shopping centre also has many employment agencies, tailoring ships, printing services, eye care stores, cosmetic shops, and many others. You can spend an entire day in the centre doing all your shopping, or just walking around. And when you are there, you can eat at a variety of different place, depending on what it is that you are in the mood for.
Katong is situated in a complex that is home to many other local shops and stores. When you leave the shopping centre, if you care to visit any of the other places, they are all within walking distance from your parking space. And because there are many different housing complexes all around the area, it makes for a very easy place to go and take care of everything that you need to take care of, all in one convenient area.
The shopping complex is quite a luxurious location, given that it can be reached from many different ways. It's proximity to. Not only that, but it is near several bus stops which makes it easier for anyone who wants to shop. Whether you drive, ride the bus, or walk there, the Katong Shopping Centre is a place where families and friends can get together and have fun.


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Sufism in muslim religious trends during the Middle Ages
The contradictory trends in Islamic civilization - social strife and political divisions versus expanding trading links and intellectual creativity - were strongly reflected in divergent trends in religious development in the later centuries of the caliphate.
On the one hand, Sufist mysticism injected Islam with a new vibrancy and expansiveness; on the other hand, orthodox religious scholars, such as the ulama, grew increasingly suspicious of and hostile to non-Islamic ideas and scientific thinking. The Crusades had given great impetus to the latter trend, particularly with regard to Muslim borrowing from ancient Greek learning that the ulama associated with the aggressive civilizations of Christian Europe.
Many orthodox scholars came to suspect that the propensity for empirical testing and seemingly endless questioning of the Greek tradition posed potential challenges to the absolute authority of the Quran, which they insisted was the final, perfect, and complete revelation of an all-knowing divinity.
Brilliant thinkers like al-Ghazali (1058-1111), who was perhaps the greatest of Islamic theologians and whose ideas indirectly influenced major Christian European philosophers such as Thomas Aquinas, struggled to fuse the Greek and Quranic traditions, achieving mixed success in terms of acceptance by orthodox scholars.
Much of the religious vitality in Islam in the later Abbasid period (750-1258) was centered in the Sufist movement. Like the Buddhist and Hindu holy men earlier in India, Sufis (whose title was derived from the woolen robes they wore) were wandering mystics who sought a personal union with God. In its various guises - including both Sunni and Shi'a manifestations - Sufism was a reaction against the impersonal and abstract divinity that many ulama scholars argued was the true God of the Quran.
Source text history-world.org Illustration: The tomb of Sheikh Rukn-ud-Din Abul Fath in Multan, Pakistan, where various Sufi Saint tombs are located; source wikipedia
Sufism in muslim religious trends during the Middl...


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text:
THE BOOGALOO CREW
Boogaloo beats to move your feet, Live covers and bootlegs, beat mixed and remixed with DJ + Live Vocals, Sax & Percussion for an eclectic, electric show.
Few bands have the talent or tenacity to ignite dancefloors with a heady mix of Stevie Wonder, Blondie, Jamiroquai, Madonna, Funkadelic, Santana, Tears for Fears, Kelis, Pink, Basement Jaxx, Armand Van Helden, Stardust and more…
There's singer/MC Anita, commanding the audience from the front – who puts the FUN back into FUNKY with her hot & fiery vocals; Andre Pacifico on percussion, who was brought up on a healthy music diet consisting of everything from Elvis to Jimi Hendrix, the Beatles and even Frank Sinatra; Jay Cee on the saxophone, the horn of all horns, a horny hunk with all the right junk, who also plays with funk rock band King Farook; and Sydney-born, Spanish-bred DJ/Producer Abel el' Toro on the wheels of steel. Abel's name is synonymous with Sydney's party scene from day one, producer/remixer to the stars and skilled in using his vast collection of samples and loops, coupled with scratching and cutting to bring together the sound of The Boogaloo Crew.
The Boogaloo Crew will keep your party rocking to the best of the funky hits from the past 30 years. Party anthems, disco, funk, soul & club grooves, all served up with fun & flavour!
Event highlights: Bacardi Marquee @ Randwick Races, Bacardi Festival (Darling Harbour), Cargo Bar, The Eastern, Mars Lounge, The Palace, The Roxy, Plantation, Plan B. Overseas Passenger Terminal, Label M, The Burdekin Hotel, Equilibrium, Kinselas, 34B and King Street Hotel (Newcastle).
Support highlights: Dimitri From Paris, Pete Tong (UK), La fiesta Sound System, Sneaky Sound System, The Martini Club, Hed Kandi, Ministry of Sound, Mark Dynamix, Andy Van and Carl Kennedy.
Band/Artist/Act:The Boogaloo Crew
Info:The Boogaloo Crew features DJ Abel El Toro and some of Sydney's finest musicians.


text:
Deuteros: The Next Millennium, un jeu vidéo,
 Deutéros, un personnage de Saint Seiya.


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Welcome to Automobiles Etcetera, where we cater to your ultimate automotive experience.
From our state of the art facility, we specialize in only the finest selection of pre-owned, prestigious, exotic, classic, vintage and muscle cars to be found anywhere.
We also offer on-site certified service, complete detailing, as well as VIP concierge.
Automobiles Etcetera presents a comprehensive inventory of refined way. Used cars listed among the inventory are available for immediate delivery. They went through a series of tests and checks before listing. Find easily the type, brand orthe model sought through our targeted search filter. Also use the progressive or regressive display tool, according to the criteria of your choice, the price for example, to locate you faster compared to your budget. Automobiles Etcetera offers an unparalleled online shopping experience.


text:
Q: WCF Service to return simple JSON result I am trying to figure out the simplest way to return the following JSON string:
{"0":"bar1","1":"bar2","2":"bar3"}

I'm more than capable of returning something like the following class object to JSON:
Person person = new Person()
{
    foo1 = "bar1",
    foo2 = "bar2",
    foo3 = "bar3"
};

{"foo1":"bar1","foo2":"bar2","foo3":"bar3"}

I'm just wondering how I would return keys as integer strings instead?

A: You can use the [DataMember] attribute (using the Name property) to change the name of the property in the serialized JSON, as shown below.
public class StackOverflow_18081074
{
    [DataContract]
    public class Person
    {
        [DataMember(Name = "0")]
        public string Foo1 { get; set; }
        [DataMember(Name = "1")]
        public string Foo2 { get; set; }
        [DataMember(Name = "2")]
        public string Foo3 { get; set; }
    }
    [ServiceContract]
    public class Service
    {
        [WebGet]
        public Person Get()
        {
            return new Person
            {
                Foo1 = "bar1",
                Foo2 = "bar2",
                Foo3 = "bar3"
            };
        }
    }
    public static void Test()
    {
        string baseAddress = "http://" + Environment.MachineName + ":8000/Service";
        WebServiceHost host = new WebServiceHost(typeof(Service), new Uri(baseAddress));
        host.Open();
        Console.WriteLine("Host opened");

        WebClient c = new WebClient();
        Console.WriteLine(c.DownloadString(baseAddress + "/Get"));

        Console.Write("Press ENTER to close the host");
        Console.ReadLine();
        host.Close();
    }
}

redpajama_set_name: RedPajamaStackExchange


text:
using Dufry.Comissoes.Domain.Interfaces.Validation;

namespace Dufry.Comissoes.Domain.Entities.Specifications.SelfServiceSpecs
{
    public class SelfServiceDtFimIsRequiredSpec : ISpecification<SelfService>
    {
        public bool IsSatisfiedBy(SelfService selfservice)
        {
            return selfservice.DT_FIM.ToString().Trim().Length > 0;
        }
    }
}

redpajama_set_name: RedPajamaGithub


As a long-time observer of the retail side of our business I find myself asking, with greater frequency and incredulity, "what are they thinking?" Here are some of my favorites, and they're general enough to apply broadly to a lot of readers' businesses. Maybe even yours.
What are owners thinking when they say they want their managers and employees to "take ownership" of their jobs and their stores?
What they really mean to say is that they want their employees to handle difficult situations and take initiatives in exactly the same way as their boss, without the benefit of being told what to do. In other words, they want their employees to act like their mental clones – which wouldn't be such a good idea in most cases.
Asking employees to take "ownership" makes the big assumption that the employee knows which things she can take ownership of, and which things she can't, again, without being told. When solving a tough customer problem, for example, wrong decisions about how to handle difficult customer issues are fraught with danger for the employee who "takes ownership" and does the obvious right thing. That's because the "right thing" may not be in line with the owner's way of thinking which is often self-serving and based on "the realities" of our business. Such things as long delivery times, fabric outages, credit holds, internal errors, quality or service issues – anything that might cost the company money to fix – all fall into the realm of the employee being expected to "take ownership" around how the customer is handled.
Sales associates and customer service people are the most likely people to square off face-to-face with angry customers while the owner stays cozily cloistered in his office. Owners, however, often think that customers should understand their side of a problem. Employees are, of course, in the middle of this dilemma.
I use the word "dilemma" instead of "problem" because there is a distinction that has to be understood: problems have solutions; dilemmas don't. The answer to a dilemma is most often to cut everyone's losses and get out of it.
Leaving dilemmas or problems open and unresolved in an organization for long periods actually costs far more in both dollars, morale and customer satisfaction than an immediate resolution would have. Let's say that a service tech is sent out to inspect an obvious problem with a piece of furniture in a customer's home. Using an Ocam's Razor approach and taking the simplest route to a solution will, in practically all cases, be the cheapest and most effective way of resolving the problem. Replace it. No service trail, no service order tracking system, no tech costs with gas prices at the highest level ever.
Replace it and fix the bad one in the shop for resale. Granted, custom order goods are a different issue in most regards, but not in the customer satisfaction one.
Interestingly, most managers will almost always take the Ocam's Razor approach of "get it done, make the customer happy, and off my plate".
Interestingly enough, they would most likely be chastised for doing so by an owner who is focused on the organization's protective processes and procedures or on this month's financials. Just what are they thinking when they ignore the long term, hidden, cultural, market, and organizational costs? The answer is – not much.
Another favorite "what were they thinking?" situation is that often wacky world of purchasing in the furniture business. I have met dozens – no, hundreds, of independent furniture retailers who can point to operating profits on the income statement, but who have no cash on hand. Today that is a deadly situation because of the difficulty of finding financing for inventory. It's not just difficult, it's nearly impossible for marginal retailers without very strong balance sheets.
There are only a few places that operational "profits" can be found; in the bank, in the warehouse in the form of inventory, or in the owner's bank account and other personal assets. Mostly though, it's found in the warehouse. I recently met a retailer with several stores in a major metro market who had over $2 million in dead inventory in his warehouse, and no cash on hand. All of it was stock purchased at speciously large discounts from overseas vendors in container quantities. "I've got 60 points on that stuff" he said.
We all know it is not possible to live long on Earth if you believe you can negotiate with gravity. Most of us wouldn't have lived beyond the fist tree-climb if we didn't learn this truth early on in life. Well, there's a gravity-like rule in the business world, too. It's called Praeto's Principle otherwise known as the 80/20 rule, or the Law of Imbalance. It says that 80% of all outcomes will be generated by 20% of all causes – or something like that. In our business, the metric that is used to "negotiate" with Praeto's Principle is GMROI. It's amazing that a large number of buyers in our industry know little to nothing about their GMROI. What are they thinking? – Not much.
If you have a favorite "What are they thinking?" issue, send it to FURNITURE WORLD at joecapillo@furninfo.com.


We found out that a recent hire received allegations of sexual abuse last year for an incident that happened in 2011. He denies that it happened, alleged victim did not pursue charges, no other accusers have stepped up. Management stands by decision to hire him. People have been talking around the workplace. And google is just a few clicks away. What should management do?
If they have made their decision, stand by it.
Your question raises no legal issue. It's entirely a question of business/employee management.


Former UCLA Bruins basketball player Billy Knight was found dead in Phoenix on Sunday after apparently committing suicide. In the emotional video, Billy said: "I am lost in life and I feel like there is no hope..." I was a taker. "I just asked God for forgiveness for all the wrong I've done". I isolated myself from my friends. UCLA fans have been dealt a second heartbreaking loss, as just this past weekend, former Bruin, Tyler Honeycutt, lost his life in a shootout with the police.
Mental illness is a bad disease and should be treated very seriously.
Earlier Sunday, TMZ reported, Knight posted a six-minute video to YouTube that was an apparent suicide note.
Knight broke out at UCLA in 2001 - when he started all 33 games and averaged 14 points on 46 percent shooting from the floor.
Knight, 6-foot-6 guard/forward, played four seasons at UCLA.
He said he heard voices and didn't know where they came from.
"The secret of living is giving". He also noted that he "felt like I didn't belong here on earth". I couldn't obey the laws, I couldn't fit into society, so now I'll take my chances. "I will be in Heaven or Hell".
After graduating from UCLA, Knight went undrafted and spent time in the National Basketball Association D-League before going to the Harlem Globetrotters and playing overseas. The team issued a statement Tuesday saying officials were "deeply saddened" by his passing. Following his playing career, he would become a basketball operations assistant for the G-League's Northern Arizona Suns, an affiliate of the Phoenix Suns, from 2016-2017.
Phoenix Suns forward Jared Dudley responded on Twitter after learning of Knight's death.


text:
HomeExpats in Haikou48 hours negative nucleic acid results for hospital treatment and 24 for...
48 hours negative nucleic acid results for hospital treatment and 24 for admission
Hospitals in Haikou now require negative nucleic acid results within 48 hours for treatment and 24 for admission
Updated December 7th:
Patients and accompanying persons can see a doctor with a negative nucleic acid result taken within 48 hours (subject to the time of reporting) and a green health code.
To be admitted, patients and accompanying persons must have negative nucleic acid results taken within 24 hours (subject to the time of reporting) and a green health code.
Haikou People's Hospital announced that starting from December 6th, patients must have negative nucleic acid results within 48 hours to go to the hospital for treatment or 24 hours negative nucleic acid results for admission.
Outpatients:
Many hospitals have implemented an outpatient appointment system, where patients must adhere strictly to the appointment schedule to see a doctor, in order to avoid groups of patients gathering.
Patients and accompanying persons who have come from normal epidemic prevention and control areas or low-risk areas within the province (within the last 7 days), and have no common symptoms of COVID-19 or other epidemiological history, should go to hospital with a green health code and negative nucleic acid results taken within 24 hours (subject to the reporting time).
If you have a travel history outside the province (non-high-risk areas) or cities and counties with clusters of local cases (non-high-risk areas) within 7 days, you must have Pnegative nucleic acid results, 2 tests within 3 days in the province (the interval between 2 samples ≥ 24 hours), the last nucleic acid result must be within 24 hours, and should not include a landing inspection test.
All patients and accompanying personnel must wear masks correctly when entering the hospital area, and cooperate with medical staff to conduct epidemiological investigations in accordance with laws and regulations, and epidemic prevention and control requirements.
Patients with a fever (≥37.3°C), dry cough or other respiratory symptoms should go to a fever clinic. Patients who have a travel history in high-risk control areas within the last 7 days, have a yellow or red health code, have other epidemiological history, or have a history of travel in Hong Kong, Taiwan or overseas within the last 90 days, please go to the fever clinic or red/yellow code hospital for treatment.
In case of emergency, please go directly to the emergency department for treatment.
Inpatients:
If you have lived in a normal epidemic prevention and control areas or low-risk areas in the province within the last 7 days, you'll need a green health code, with nucleic acid negative results taken within 24 hours (subject to the reporting time).
If you have a travel history outside the province (non-high-risk areas) in cities or counties with clusters of local cases within the last 7 days (non-high-risk areas) you must have a green health code, with negative nucleic acid results, 2 tests within 3 days in the province.
The wards adopt closed management; except for special medical needs, patients and their companions are strictly prohibited from going out.
For patients who really need someone to accompany them, the doctor in charge will issue a doctor's order, the department director, and the head nurse will sign the accompanying management commitment letter, and it is strictly enforced that one patient can only be accompanied by one person.
Accompanying nucleic acid requirements are the same as admitted patients.
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