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December 24, 2020 December 24, 2020 by Guarttes
Mauricio Pochettino has agreed to become the new Paris Saint-Germain manager.
The Argentine is set to replace Thomas Tuchel, who was sacked by the French giants on Thursday morning.
The ever reliable Fabrizio Romano confirmed the news on Twitter, writing: "Mauricio Pochettino has reached an agreement with Paris Saint-Germain, confirmed.
"Now it's time to prepare the contracts, sort out the last details [as the choice of the technical staff] and sign.
"Here-we-go soon! The new era is starting."
Pochettino has been away from management since leaving his role at Tottenham in November 2019.
He played for PSG for two years and he spoke about returning to the club back in 2016.
"I've always said that I would be pleased to join a great club like PSG," Pochettino told RMC.per the Guardian.
"Come to Paris? I hope so. It is true that it would please me. It's part of my dreams. I try to watch all their matches, especially in the Champions League.
"The [French] championship is not very attractive because PSG is far from the other teams but I look a lot because it is a major source of players. There is talent so I have to follow Ligue 1."
Pochettino will take over a PSG side that are third in Ligue 1, just one point off league leaders, Lyon.
PSG are also in the last-16 of the Champions League and Pochettino will be given the task of finally ending the club's wait for the trophy.


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Q: Making a string property ObjectId in MongoDB with C# I just started with MongoDB. I am using it with C# drivers. Currently C# class looks like this:
 [BsonRepresentation(BsonType.ObjectId)]
        public string Id { get; set; }
        public string userId { get; set; }
        public List<string> filters { get; set; }

With this class I am able to save and fetch the records in MongoDB.
What I want:- Instead of creating a separate property to hold ID (in my case its Id property), I want to make userId property as the ObjectId.
Please note, I will be supplying the userId which will be a unique string value. Is it possible to achieve this with MongoDB?

A: Sure it is possible.
just put [BsonId] on userId prop and delete Id property

redpajama_set_name: RedPajamaStackExchange


Seemed like a brilliant idea at the time: Rather than moderate a typical panel, I elected to host a game show, calling it Facebook Faceoff. Mix things up. Wake up the crowd on Captiva. We were, after all, the first panel up after the keynote speaker -- a usually dreaded spot during which email is checked and energy wanes.
So why not hit the audience with a little Jeopardy/Match Game/You Bet Your Life-inspired razzle-dazzle? Well, while it all seemed to work out okay in the end, here are five reasons why the game show format won't replace panels any time soon (but probably should).
Having sharp "contestants" who were fully prepared to express a point of view in 90 seconds or less led to startling levels of succinctness. For example, Lucy Jacobs of Spruce Media made the unembellished case for being a Facebook Strategic Preferred Marketing Developer by noting: "We get advanced insights into their [Facebook] roadmap and work with Facebook on Alphas and Betas [which in turn helps our clients] get ahead of the curve." Ten points for Lucy's pith!
The surprising truth of being a game show host is that it is really hard to pull off if your audience isn't pumped up for the show. Needless to say, the attendees at the Social Media Insider Summit had no idea what to expect when the theme song for Match Game started playing and I began my over-enthusiastic intro. That said, as the show went on, the crowd did warm up and even applauded enthusiastically when contestant Smith said the secret word, "Zuckerberg," and earned a limited edition "Billionaires are Overrated" t-shirt.


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Ingerophrynus és un gènere d'amfibis de la família Bufonidae que conté 11 espècies.

Taxonomia

Referències

redpajama_set_name: RedPajamaWikipedia


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Effects of γ-aminobutyric acid-enriched fermented sea tangle (Laminaria japonica) on brain derived neurotrophic factor-related muscle growth and lipolysis in middle aged women
Wook-chul Choi1, Storm N. S. Reid1, Je-kwang Ryu2, Yunsook Kim3, Young-Hong Jo4, Byeong Hwan Jeon1,
1Departent of Physical Education, School of Sports and Health, Kyungsung University, Busan 48434, Korea
2Institute for Cognitive Science, College of Humanities, Seoul National University, Seoul 08826, Korea
3Marine Bio-industry Development Center, Marine Bioprocess Co., Ltd., Busan 46048, Korea
4Research and Development Team, Taekyung Food & Processing, Seoul 07057, Korea
*Corresponding Author: E-mail: mooaworld@ks.ac.kr Tel: +82-51-663-4951, Fax: +82-51-663-4959
Received 2016 March 20; Accepted 2016 June 12.
This study evaluated the effects of γ-aminobutyric acid (GABA)-enriched fermented sea tangle (GFST), as a functional food, on brain derived neurotrophic factor (BDNF)-related muscle growth and lipolysis, in a sarcopenic obesity high-risk group. Twenty-one middle-aged women (53-63 y) participated in this randomized, double-blind, placebo controlled study. Participants ingested either 1,000 mg of GFST (n = 10) or a sucrose placebo (CON) (n = 11) everyday, for 8 weeks. Subjects were asked to abstain from any regular exercise. Fasting venous blood samples, body composition and muscular strength were measured before and after supplementation period. Collectively, we demonstrated that GFST significantly decreased total fat mass and triglyceride in body composition, as well as significantly increasing serum BDNF (p < 0.001), angiotensin converting enzyme (p < 0.001), human growth hormone and insulin-like growth factor-1 levels (p < 0.05 and p < 0.05, respectively) accompanied by increased total lean mass (p < 0.01). Furthermore, the reported improvements in total work, knee extension and flexion at 60° s-1 (p < 0.05), and peak torque normalized to body weight of knee flexion at 60-1 (p < 0.05), support an ergogenic effect of GABA associated with increased growth factor levels. The use of GFST, as a functional food ingredient, to elicit anti-obesity effects and stimulate the release of muscle-related growth factors with increasing serum BDNF levels may provide a protective intervention for age-related degeneration such as sarcopenic obesity.
Keywords: brain derived neurotrophic factor; fermented sea tangle; γ-aminobutyric acid; sarcopenic obesity
The progressive loss of muscle mass and volume, termed sarcopenia, often leads to functional deterioration and subsequent increases in the incidence of frailty, falls and disability, commonly coupled with high levels of adiposity (sarcopenic obesity [SO]). The multi-factorial nature of SO, mediated by numerous mechanisms, including alpha-motor neuron death, altered hormone concentrations, increased inflammation and altered nutritional status (Jones et al. 2009), necessitates comprehensive and efficacious interventions through exercise, nutrition, pharmacology, or otherwise.
Sea tangle is used frequently and widely across China, Japan, and Korea as a seasoning or dietary ingredient. Sea tangle consists of protein, amino acids, minerals, polyphenols, and insoluble cellulose rich in dietary fibre (Cha et al. 2011a). Once subjected to a highly specialized lactic acid fermentation process, using Lactobacillus brevis BJ20, glutamic acid within the sea tangle is bio-converted into γ-aminobutyric acid (GABA). GABA is a non-protein amino acid specifically functioning as an inhibitory neurotransmitter in the central nervous system. GABA has been reported to induce hypotensive effects and provide diuretic and tranquillizer effects (Inoue et al. 2003). Furthermore, supplementation of GABA-enriched fermented sea tangle (GFST) has been linked to liver protection effects (Lee et al. 2010b, Cha et al. 2011b) and improvements in antioxidant levels (Lee et al. 2010a), obesity status and stress management (Okai et al. 1993, You et al. 2009). GABA supplementation has also been associated with an elevation in the levels of human growth hormone (HGH) in healthy (Cavagnini et al. 1980b) and trained men, and through this, may lead to further effects on substrate metabolism, including lipolysis and skeletal muscle protein accretion (Turner et al. 1988, De Palo et al. 2006). An angiotensin-converting enzyme (ACE) inhibiting effect has also been demonstrated following GABA-enriched food ingestion, which could contribute to enhanced skeletal muscle function (Witham et al. 2008).
Loss of neuromuscular integrity is closely associated with sarcopenia (Cruz-Jentoft et al. 2010). Brain derived neurotrophic factor (BDNF) is the most prevalent neurotrophic factor in the central nervous system, and one of a number of proteins responsible for growth, differentiation and survival of neurons. Alterations in BDNF expression and signaling, linked to neurodegeneration, are typically in reference to "brain derived" rather than peripheral sources, however, BDNF is present in blood platelets (Fujimura et al. 2002), muscle cells, vascular beds, macrophages, and leucocytes (Gielen et al. 2003, Cattaneo et al. 2010), where it may be synthesized and released. Reduced serum BDNF has been soundly implicated in the pathogenesis of neurodegenerative diseases (Ventriglia et al. 2013) including dementia (Lee et al. 2009), Alzheimer's disease (Laske et al. 2007), and Parkinson's disease (Scalzo et al. 2010). Furthermore, it has been put forward that skeletal muscle-derived BDNF has a protective function on innervating motor neurons, potentiates neuromuscular transmissions and, of particular interest, stimulates protein synthesis (Oppenheim et al. 1992, Zhang and Poo 2002). Thus, on the basis of previous literature, we hypothesized that the consumption of GFST would increase the levels of blood serum biomarkers associated with muscle building and body fat status, while investigating neuromuscular survival via increased BDNF.
Twenty-one middle-aged women (53-63 y) participated in this randomized, double-blind, placebo controlled study (Table 1). Subjects whom suffered with hypertension, chronic degenerative disease (arthritis), diabetes, obesity, and cardiovascular disease were excluded from the study. Adverse reaction to supplementation prior to the experimental period or inability to participate due to particular medication resulted in exclusion. All subjects were physically active taking part in moderate aerobic exercise (1-2 times per week). All participants completed a written informed consent to participate in this study, which was approved by Kyungsung University Ethics Committee (KSU-14-05-002).
Participant characteristics
Preparation of GFST by Lactobacillus brevis BJ20 and placebo
GFST was prepared by a previously adopted, but modified, procedure (Park et al. 2016). Sea tangle was added to water at a ratio of 1 : 15 (w/v) with the addition of yeast extract and glucose, based on the amount of sea tangle added to the mixture. After autoclaving at 121°C for 30 min, a sea tangle solution was obtained and the Lactobacillus brevis BJ20 (accession No. KCTC 11377BP) culture broth was added to the solution at a concentration of 1.2% (v/v) (Table 2), which was mixed and incubated at 37°C for 2 days (Fig. 1). A soft capsule was made for the clinical trial by mixing 250 mg fermented sea tangle, 61 mg lactose, 32 mg cellulose, 5 mg HPC, 30 mg SiO2, and 7 mg magnesium stearate. A placebo was made by mixing 311 mg lactose, 32 mg cellulose, 5 mg HPC, 30 mg SiO2, and 7 mg magnesium stearate.
Culture broth composition
Preparation process of γ-aminobutyric acid (GABA)-enriched fermented sea tangle (GFST) from raw sea tangle.
During the preparation process, the GABA content had been controlled to range between 40-60 mg within 1,000 mg of GFST. Based on high performance liquid chromatography analysis, it was confirmed that the mean content of GABA was 54.5 ± 0.071 mg g-1 in the GFST used in this study.
General protocol
Over the experimental period, participants ingested ei-ther 1,000 mg of GFST (n = 10) or a sucrose placebo (CON) (n = 11) everyday, for 8 weeks. Subjects were asked to abstain from any regular exercise. Fasting venous blood samples were taken before and after the 8 weeks period.
Measurements of total lean mass (TLM) and total fat mass (TFM) were carried out at the Medical Centre for Health Promotion (Busan, Korea) using the DEXA (Dual Energy X-ray Absorptiometry; Discovery QDR Hologic, Bedford, MA, USA). Subjects were fitted with robes and had their measurements taken by professionally trained assistants, taking 15 min for the entire body.
Biochemical analysis on blood
Fasting venous blood samples were taken before and after the 8 weeks period. Collected blood samples were clotted for 30 min centrifugation for 15 min at 1,000 ×g separated into serum and stored at -80°C and analyzed by immunoassay.
Serum substrates and inflammation factors
Glucose substrate is an indispensable energy supplier which supports cellular function. Glucose degradation occurs in glycolysis. The hexokinase method, based on the work of Schmidt, Peterson and Young, is a recognized reference method according to the manufacturer's procedures (COBAS; Roche Diagnostics, Indianapolis, IN, USA).
Concentrations in serum of triglyceride (TG), high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were enzymatically measured with commercial kits (COBAS; Roche Diagnostics).
Tumor necrosis factor α (TNF-α) Immunoassay to measure TNF-α in serum, was performed by using a Quantikine HS ELISA kit provided from R&D Systems, Inc. (Minneapolis, MN, USA). It is insensitive to the addition of recombinant forms of either of the two types of soluble receptors. It is probable that this measurement detects the total amount of TNF-α in serum, i.e., the total amount of free TNF-α plus the amount of TNF-α bound to soluble receptors. Optical density was determined at a wavelength of 490 nm.
Immunoassay to measure interleukin (IL)-6 in serum was performed by using a Quantikine HS ELISA kit provided from R&D Systems, Inc. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.
Growth-related factors
For measuring BDNF concentrations, a commercially available kit from R&D Systems, Inc. was used. Diluted serum was used to determine the optical density of each sample well within 30 min at 450 nm.
ACE mediates the cleavage of the synthetic substrate (FAPGG; N-[3-(2-furyl)acryloyl]-L-phenylalanyl-L-glycyl- L-glycine) into an amino acid derivate and a dipeptide. The kinetic of this cleavage reaction is measured by recording the decrease in absorbance at 340 nm using a commercially available kit from BÜHLMANN Laboratories (Basel, Switzerland).
HGH concentration was determined using, a commercially available kit, Immulite 2000 from Siemens AG (Muenchen, Germany). A growth hormone releasing hormone + arginine stimulation test calibrated with both IS 80/505 and IS 98/574 (GRH Growth hormone-Recombinant 98/574-kit).
Insulin-like growth factor-1 (IGF-1) concentrations were measured using a solid-phase, enzyme-labeled chemiluminescent immunometric assay on the Immulite 2000 automated immunoanalyzer (Siemens AG).
Strength measurements
Isokinetic strength was measured using a Biodex machine (Biodex System 4 Pro; Biodex, Shirley, NY, USA). With subjects seated, the dynamometer was adjusted to match the rotational axis of the worked extensors and flexors. Participants were encouraged to remain seated, not moving other body parts except for the pelvis, with additional external forces applied (straps) to prevent movement of the femoral site and chest. Attachments were used to accommodate for leg length ranges of motion. Isokinetic knee flexion and extension were measured in the anatomical position, through 90°-0° and again from 0°-90° whilst being adjusted for hyperextension. Load speeds of 60° s-1 were performed on the lower limbs to assess muscle strength. All strength measurements were recorded within 7 days of starting the experimental period and 3 days of completion.
Indicators of fatigue and damage on liver and muscle
Aspartate aminotransferase (AST, or glutamate oxalacetate transaminase) and alanine aminotransferase (ALT, or glutamate pyruvate transaminase) both belong to the transaminases, which catalyze the interconversion of amino acids and α-keto acids by transfer of amino groups. A standardized procedure provided by the manufacturer (COBAS; Roche Diagnostics) was used for AST and ALT determination. ALT determination included optimization of substrate concentrations, employment of Tris buffers, preincubation of a combined buffer and serum to allow side reactions with NADH, substrate start and pyridoxal phosphate activation. AST measurement, included optimization of substrate concentrations, employment of Tris buffers, preincubation of a combined buffer and serum to allow side reactions with NADH to occur, substrate start, and optional pyridoxal phosphate activation.
Creatine kinase (CK) is rapidly inactivated by oxidation of the sulfhydryl groups in the active center. The enzyme can be reactivated by the addition of acetylcysteine (NAC). Interference by adenylate kinase is prevented by the addition of didenosine pentaphosphate and AMP. Standardized methods for the determination of CK were used: "reverse reaction" and activation by NAC according to the manufacturer's method (COBAS; Roche Diagnostics).
All statistical analysis was conducted with Statistical Package for Social Sciences (SPSS Windows ver. 18.0; SPSS Inc., Chicago, IL, USA). Descriptive statistics (mean and standard deviation) were used to report on the measurements of each variable. A student paired t test and ANCOVA analysis were conducted to identify within and between group differences. Statistical significance was set at α = 0.05.
Between-group differences in TLM were shown to be significantly different when comparing GFST and CON groups' pre- and post-test values (p < 0.01) (Fig. 2H). However, no within-group significance was found. TFM reduced significantly in the GFST group (p < 0.05), but not in the CON (Fig. 2I).
Changes in blood concentrations of morphological, metabolic, hormonal, and neurotrophic factors: angiotensin converting enzyme (ACE) (A), brain derived neurotrophic factor (BDNF) (B), human growth hormone (HGH) (C), insulin-like growth hormone-1 (IGF-1) (D), triglyceride (TG) (E), low-density lipoprotein (LDL) (F), high-density lipoprotein (HDL) (G), total lean mass (H), total fat mass (I), and tumor necrosis factor-α (TNF-α) (J). All measurements were determined before and after the experimental period. Each bar represents the mean ± standard deviation. Student paired t tests and ANCOVA analysis were conducted to identify within and between group differences, respectively. Significance values are as follows: *p < 0.05, **p < 0.01, ***p < 0.001. GFST, γ-aminobutyric acid-enriched fermented sea tangle; CON, placebo.
Lipid and inflammation
There was no significant effect of GFST on blood glucose. We found a reduction in TG levels in the GFST group (p < 0.05) (Fig. 2E). There were, however, no significant changes in LDL or HDL levels observed, though a notable increase was seen in the latter (Fig. 2G). There were no significant changes in IL-6 or TNF-α levels (Fig. 2J).
BDNF and growth-related factors
No significant within-group effect was observed in BDNF serum levels, but a between-group difference (Fig. 2B) was observed (p < 0.001). A significant reduction was observed in the GFST (p < 0.001) group with respect to ACE concentrations, and between groups (p < 0.01) (Fig. 2A). There was, however, a significant effect of supplementation on HGH levels (p < 0.05), also significantly different between groups (p < 0.001) (Fig. 2C). IGF-1 increased significantly in the GFST experimental group (p < 0.05) (Fig. 2D).
Muscle strength
Muscle strength of the lower limb was shown to significantly improve in the GFST group for total work, knee extension and flexion at 60° s-1 (p < 0.05), and peak torque normalized to body weight of knee flexion at 60° s-1 (p < 0.05) (Fig. 3A, B & D, respectively). Peak torque normalized to body weight of knee extension also tended toward increasing but didn't reach significance.
Changes in muscle strength parameters. Lower limb strength measured as total work (T/Work) at 60° s-1 extension (A) and flexion (B), and peak torque normalized to body weight (PeakTQ/BW) at 60° s-1 extension (C) and flexion (D) pre- and post-test. Student paired t-tests and ANCOVA analysis were conducted to identify within and between group differences, respectively. Significance values are as follows: *p < 0.05, **p < 0.01, ***p < 0.001.
Sea tangle is an ingredient rich in vitamins, minerals, essential fatty acids, carotenoids and bioactive compounds such as alginates and fucoidans. Supplementation of sea tangle has been associated with numerous health benefits, including anti-hyperlipidemia and anti- atherosclerosis effects (Lee et al. 2011), hypotensive (Chiu and Fung 1997) and antioxidant activities (Han et al. 2002).
Sea tangle was fermented to enrich the GABA content and evaluate the potential health benefits on SO. The prevailing research has focused on the acute changes induced by oral GABA administration with few studies on functional food intake, and to our knowledge, few reports have rigorously tested the effects of GABA rich functional foods on other biomarkers associated with neuromuscular function, body composition, blood glucose, and cholesterol status. The findings of the present study show an increase in growth factors and improvements in total body fat and lean muscle status, following GFST supplementation, via multi-mechanistic pathways (Fig. 3). Of notable interest was the increased BDNF in the experimental group along with muscle growth factors, ACE, HGH, and IGF-1.
The role of neurotrophic growth factors in neurodegenerative conditions has been the predominant focus of research surrounding nervous system health and function. However, BDNF is attracting attention for its association with neuromuscular disorders and sarcopenia. The Akt/protein kinase B activated mammalian target of rapamycin (mTOR) pathway has emerged as a key regulator of skeletal muscle hypertrophy (Lai et al. 2004), and shows a decreased activation (Kimball et al. 2004) and phosphorylation status with ageing (Haddad and Adams 2006). Muscle membrane tyrosine kinase B (TrKB) receptors are thought to play a role in providing a binding site for BDNF to activate the Akt/mTOR/p70S6K signaling pathway leading to protein synthesis (Sakuma and Yamaguchi 2010). In this study we demonstrated that GFST increased serum BDNF levels when baseline values were not significantly different. This indicates GFST as a viable functional food which may create an environment conducive for muscle protein synthesis. In addition, research has shown the fat oxidation AMPK-ACC signaling pathway to be enhanced as a result of BDNF induced phosphorylation in skeletal muscle (Pedersen 2011) potentially via acting in an autocrine and / or paracrine manner within skeletal muscle (Pedersen 2013). BDNF, also being low in obesity, implies a role for BDNF in the regulation of central and peripheral metabolism, potentially linked to the reduction in TFM observed in the present study. Taken together, BDNF may be identified as a myokine that influences myogenesis, muscle regeneration, and metabolism (Pedersen 2013). More studies are warranted to establish a role for GABA-related BDNF expression in SO, investigating the longitudinal effects of GABA supplementation on BDNF, and whether these translate to improvements in body composition and physical function in the ageing population.
HGH plays a key role in the maintenance and growth of skeletal muscle, and impacts the metabolism of lipids, carbohydrate, and protein in nearly all body tissue. Particular functions of HGH include the stimulation of protein anabolism (i.e., increased DNA, RNA, and protein synthesis), enhanced utilization of fats by stimulating triglyceride breakdown and oxidation of adipocytes and antagonism of insulin action (a key regulator of carbohydrate metabolism). HGH is purported to gradually decline with age at a rate of ~1% per year after the age of 30 (Hermann and Berger 2001), and can be as much as 20-fold less in older than in younger adults (Ryall et al. 2008). The age-related decline in HGH, coupled with lower IGF-1 levels, the key mediator of HGH action, have also been associated with sarcopenia and detrimental changes in body composition (Ferrucci et al. 2002). The results of the current study demonstrated a significant increase in HGH as a result of GFST supplementation. Some of the early GABA research on oral supplementation showed significant elevation in plasma HGH levels in healthy men (Cavagnini et al. 1980a). It is important to note that the majority of research investigates the acute changes in HGH levels (Cavagnini et al. 1980a) whereas, the current study presents a case for long term increases in resting HGH with continual supplementation of GABA; a within and between groups effect of GFST was observed after 8 weeks (Fig. 2C). A HGH induced generation of IGF-1, in accordance with the somatomedin hypothesis (Le Roith et al. 2001), may be responsible for the significant increase in IGF-1 (Fig. 2D) (Laron 1996), and thus, an ensuing anabolic or lipolytic response (De Palo et al. 2006) demonstrated by an increase in TLM (Fig. 2H) and decrease in TFM (Fig. 2I) following GFST supplementation. Furthermore, inferring a stimulatory effect of GABA on HGH levels, the tendency toward a reduction in LDL and increase in HDL concentrations shown in the GFST group (Fig. 1G), help support the notion that following HGH release IGF-1 has a modulating role on insulin sensitivity (Moses et al. 1996) and HDL levels further downstream (Succurro et al. 2010). The relative contributions of these IGF-1 pathways require further investigation, due to the ubiquitous nature of IGF-1, IGF-1, and HGH independent growth stimulating effects (Laron 2001), and / or the possibility of GABA directly stimulating hypothalamic responses (i.e., ghrelin, growth hormone-releasing hormone, and somatostatin) (Powers 2012).
Our results may give an important contribution to the question of whether ACE inhibitor use can aid in sarcopenia treatment. The renin-angiotensin system is known to be activated in many catabolic conditions, in which ACE is responsible for converting angiotensin I to angiotensin II, in a process that regulates blood pressure and the body's fluid and sodium balance. Angiotensin II infusion resulted in cachexia and decreased circulating IGF-1. The weight loss was associated with skeletal muscle catabolism, in the presence of unchanged fat tissue, possibly via its inhibitory effect on the autocrine IGF-1 system (Brink et al. 2001), and more specifically, via the Akt/mTOR/p706SK pathway (Song et al. 2005). Thus, the inhibitory effect of GABA on ACE demonstrated in the present study, and previously evidenced in the literature (Lin and Omori 2002), points toward a major mechanistic pathway to target in catabolic conditions such as sarcopenia. The extent to which ACE inhibition contributed to the increase in IGF-1 or TLM, in the current study, is unknown, although it may act synergistically with other mechanisms (Fig. 4). Future investigation ought to be carried out on the effects of ACE inhibitors on muscle-specific IGF-I expression in healthy, ageing subjects. Of particular interest to the application of functional foods as lipid status improving agents, was the reduction in TFM (p < 0.05), increased HDL concentration and significant decrease in TG levels (p < 0.05) following GFST supplementation. Brown seaweeds are known to be rich in polysaccharides such as fucoidan, laminarin, and alginate. Fucoidan of brown seaweed has been implicated in the reduction of blood lipids (Li et al. 2008), decrease in total cholesterol, triglycerides, and LDL concentration, and increase in HDL concentration (Li et al. 2001). In addition, reduced cholesterol and triglycerides has been reported in patients with hyperlipidaemia following fucoidan ingestion (Wang and Bi 1994). Up-regulation of lipid metabolic enzymes (Huang et al. 2010) is one proposed mechanism by which fucoidan may help to improve lipid profiles. Obesity can be expressed, partly, as a state of chronic low grade inflammation in adipose tissue, caused by adipocyte hypertrophy and hyperplasia, marked by an increase in macrophage content and activity in the adipose tissue, inducing a release of cytokines and pro-inflammatory signals. Leukocyte trafficking into adipose tissue is mediated by increased endothelial expression of P-selectins and E-selectins (Nishimura et al. 2008), and the regulatory role of P-selectin glycoprotein ligand 1 (PSGL-1) on the adhesive properties of the endothelium and leukocyte. PSGL-1 deficiency was shown to have protective effects against visceral fat inflammation in mice, by reducing IL-1 receptor-mediated adhesive properties of the endothelium (Russo et al. 2010). Furthermore, antibody blockade of P- and E-selectin reduced leukocyte rolling and firm attachment in obese visceral adipose tissue (Nishimura et al. 2008). Fucoidan acts as a "selectin blocker" (Kylin 1913) and therefore may reduce selectin-dependant leukocyte rolling on endothelial cells, subsequently leading to a reduced inflammatory state. It is known that leukocyte and neutrophils correlate positively with increased visceral fat in obese individuals (Ryder et al. 2014), thus targeting the adhesive properties of endothelial cells may prove an efficacious treatment for inflammatory disease states.
Mechanism map of potential pathways γ-aminobutyric acid (GABA) may affect muscle growth and body fat reduction changes. ACE, angiotensin converting enzyme; BDNF, brain derived neurotrophic factor; GFST, GABA-enriched fermented sea tangle; IGF-1, insulin-like growth factor-1; mTOR, mammalian target of rapamycin.
Another property of sea tangle is alginate, a dietary fibre extracted from the cell walls of brown seaweed. Studies have reported a reduction in body fat percentage(Georg et al. 2012), acute modulations in human-appetite sensation (Paxman et al. 2008) and decreased gastric emptying rate attributed to alginate ingestion. Inhibition of digestive enzymes in vitro (namely, pancreatic lipase) (Wilcox et al. 2014) and altered intestinal content viscosity are proposed key factors mediating the uptake of triacylglycerol and promoting the control of energy intake (Kristensen and Jensen 2011), respectively. These effects are still inconclusive (Odunsi et al. 2010) and warrant further investigation. Special attention should be given to the effectiveness of alginates extracted from different types of seaweed, the dose-dependency of alginate usage (the more alginate the less enzyme activity) and the palatability of potential supplements.
To our knowledge, no previous studies have investigated the effects of GABA-enriched functional foods on performance outcomes, particularly strength. Our findings of significantly improved isokinetic strength (Fig. 3A, B & D) in the GFST group help support the stance that functional foods, such as GFST, can significantly enhance growth factor levels, such as HGH and IGF-1, resulting in functional improvements in performance. The inclusion of functional foods as part of a holistic intervention seems an efficacious, noninvasive and practical approach in tackling SO and improving the ability to carry out active daily living tasks with age. It can also be added that no adverse effects to the liver were reported following GFST supplementation (Appendix 1). In this study, we demonstrated that GFST significantly decreased TFM and TG, as well as significantly increasing serum BDNF, ACE, HGH, and IGF-1 levels.
In conclusion, the use of functional foods, particularly GFST, to increase the levels of circulating GABA may stimulate the release of muscle-related growth factors including serum BDNF and / or affect substrate metabolism, providing a safe, protective intervention for age-related conditions such as SO. However, further studies concerning GFST as a functional food and its potential use in conditions such as SO should be addressed.
This work was supported by the Industrial Strategic Technology Development Program (10048025, development of health functional food of the brain for the elderly for the entry into the global market) funded by the Ministry of Trade, Industry & Energy (MI, Korea).
angiotensin converting enzyme
alanine aminotransferase
aspartate aminotransferase
BDNF
brain derived neurotrophic factor
γ-aminobutyric acid
GFST
GABA-enriched fermented sea tangle
high-density lipoprotein
insulin-like growth factor-1
interleukin
low-density lipoprotein
mTOR
mammalian target of rapamycin
PSGL-1
Pselectin glycoprotein ligand 1
sarcopenic obesity
total fat mass
triglyceride
total lean mass
TNF-α
tumor necrosis factor α
TrK8
tyrosine kinase B
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Appendix 1.
Change of blood biomarkers and body composition parameters
algae-2016-31-6-12-app1.pdf
Placebo (n = 11)
Treatment (n = 10)
Age (y) 59.64 57.20
Height (cm) 153.85 156.67
Weight (kg) 54.45 56.38
Sea tangle
Seed culture
Weight (g) 408.5 6,127.5 10 5 76.5 6,627.5
Percentage (%) 6.2 92.5 0.2 0.1 1.2 100
γ-aminobutyric acid-enriched fermented sea tangle : water = 1 : 15 (w/v).

redpajama_set_name: RedPajamaCommonCrawl


text:
Cork's Pat O'Leary wins B final at the Paralympics in Tokyo
The 48-year-old NUI Galway chemistry lecturer is also in action in a semi-final on Saturday
Patrick O'Leary, para-canoe sprint, in action during a training session. Picture: Diarmuid Greene/SPORTSFILE
Derek Kinnevey
PAT O'Leary's bid to make the second Paralympic canoeing final of his career is still on hold but he won the KL3 'B Final' in what he deemed his best performance of the year so far.
The Cork paddler, who finished sixth in Rio 2016, needed to make the top three to go through to the KL3 kayak final and missed out by just one place, despite his fastest time of the year.
He finished fourth in a season-best time of 42:203 behind Great Britain's Rio silver medallist Tom Kierey (41:647) in a semi-final won by Australia's Dylan Littlehales in a blistering 40:223.
But the 48-year-old NUI Galway chemistry lecturer went on to win the B final in what he felt was his best-executed race this season, giving him a great boost ahead of his VL3 semi-final in the early hours of Saturday morning.
His upcoming VL3 semi-final includes the Rio KL3 bronze medallist Caio Ribeiro de Carvalho from Brazil but Pat is the reigning European in this brand new event.
"The semi-final was tough.
To be fourth when just three went through was difficult but I knew going in I'd have to give everything and still need to be a bit lucky the way the draw had gone. It was probably the tougher of the two semi-finals.
"That was probably the fastest time I've done this year and I was happy that I gave it all I had. Then, even though the time in the B final was .2 of a second slower, that was the best race I'd done this year and I'm very happy with that.
"There's five in my VL3 semi, three to go through and you could probably cover us with a coin going over the line. It would be fabulous to make a final here but what's important is that what I get out of the race what I want to.
"I know what I'm capable of. I know what it feels like to do a really good run. If I do that and someone's ahead of me that's fine. If I do that and people aren't ahead of me that'll be even better."
Adam O'Reilly signs for St Pat's on loan from Preston


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Home Innovation Smartphones Mobility
Daily Cuppa: iPhone 5 sales disappoint, Foxconn riots, Vietnamese bloggers jailed
Apple has suspended directly selling the iPhone 5 in Hong Kong, Sharp teamed up with Foxconn for smartphone sales in Southeast Asia, and Hitachi boasted its capability to store data for hundreds of millions of years.
Written by Spandas Lui, Contributor on Sept. 24, 2012
There are still a few days before the glorious long weekend for NSW, South Australia, and the ACT, but be patient. Sit down, relax, and read about what happened in tech land overnight.
Apple may have sold 5 million iPhones over the weekend, but Wall Street analysts had expected that number to be higher. Analysts had tipped the phone to sell around 6 to 10 million during its first weekend.
Despite the upset, there is still an iPhone 5 shortage in some areas. Apple has suspended direct sales of the phone in Hong Kong, and will be using a lottery reserving system to determine who will get the phone due to scarce supply. But this has made black-market iPhone 5 sales all the more lucrative.
Apple's manufacturing partner Foxconn has temporarily shut down one of its factories in China due to a riot between workers.
At the company's Taiyuan facility, 2,000 workers clashed on Sunday, with 40 requiring medical assistance. The factory was closed on Monday.
In more positive news for Foxconn, Japanese electronics giant Sharp has paired with the company to launch smartphones in Southeast Asia.
In Vietnam, three bloggers were jailed for disseminating "anti-state propaganda."
Meanwhile, governments in the Asia-Pacific region can expect to experience more hacktivism due to increased unrest from citizens over unpopular IT laws being enforced, according to McAfee.
Speaking of hactivism, Wikileaks founder Julian Assange, who is currently stuck in the Ecuadorian embassy in London to avoid extradition to Sweden to face sexual assault charges, will be having a decision made for him very soon. The foreign ministers of Ecuador and the UK will meet later this week to end the standoff.
Lastly, Hitachi has claimed that it has found a way to store data for hundreds of millions of years. The quartz glass storage method was announced by Hitachi's chief executive officer, Hiroaki Nakanishi, in Tokyo on Monday.
Samsung's fourth quarter profit dips from poor chip and smartphone sales
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LG sees profit drop in 2022 from lower demand for consumer electronics


Nathan has been in the SolidWorks reseller channel since 2005. Prior to that, he designed rolling equipment for Halliburton. While at Halliburton, Nathan gained extensive hands on experience with Large Assembly Best Practices, Sheet Metal, Weldments, PDM, and machining. He was recently awarded the Elite Applications Engineer award from SolidWorks as confirmation of his extensive knowledge of the entire SolidWorks product line.


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Home time homework help The effect of divorce on family unity and moral values
The effect of divorce on family unity and moral values
A Culture of Divorce Brian Orchard Statistics tell us that first marriages today stand a 45 percent chance of breaking up and second marriages a 60 percent chance. But those numbers just confirm what we already knew: Divorce has increased not only in frequency but also in acceptance. Is divorce so prevalent, so acceptable a thread in the social fabric of Western culture that perhaps we have missed some rather significant developments paralleling its increase?
Want to learn more about this and related topics? Sign up for our twice-monthly email newsletter. My name is Gordon Berlin. I am the executive vice president of MDRC, a unique nonpartisan social policy research and demonstration organization dedicated to learning what works to improve the well-being of disadvantaged families.
We strive to achieve this mission by conducting real world field tests of new policy and program ideas using the most rigorous methods possible to assess their effectiveness.
I am honored to be invited to address your committee about what we know and do not know about the effects of marriage and divorce on families and children and about what policies and programs might work to promote and strengthen healthy marriages, especially among the poor.
An Old Problem
My goal is to briefly summarize the evidence in three areas: The central focus of my remarks will be to explicate the role that marital education, family counseling, and related services might play in promoting and strengthening healthy marriages and to discuss what we know about the potential of strategies that seek to ameliorate the key stressors for example, job loss, lack of income, domestic violence, and childbearing that make it difficult to form marriages in the first place or act as a catalyst that eventually breaks up existing marriages.
To summarize my conclusions: First, children who grow up in an intact, two-parent family with both biological parents present do better on a wide range of outcomes than children who grow up in a single-parent family.
Single parenthood is not the only, nor even the most important, cause of the higher rates of school dropout, teenage pregnancy, juvenile delinquency, or other negative outcomes we see; but it does contribute independently to these problems.
Neither does single parenthood guarantee that children will not succeed; many, if not most, children who grow up in a single-parent household do succeed. Second, an emerging body of evidence suggests that marital education, family counseling, and related services can improve middle-class couples' communication and problem-solving skills, resulting initially in greater marital satisfaction and, in some cases, reduced divorce, although these effects appear to fade over time.
An Analysis of Diocesan Marriage Preparation Policies
Third, we do not know whether these same marital education services would be effective in reducing marital stress and eventual divorce among low-income populations or in promoting marriage among the unmarried. Low-income populations confront a wide range of stressors that middle-class families do not.
The evidence is limited, and mixed, on whether strategies designed to overcome these stressors, for example, by providing job search assistance or by supplementing low earnings, rather than relying solely on teaching marital communication and problem-solving skills would also increase the likelihood that low-income couples would marry or that married couples would stay together.
Fourth, to find out whether and what types of policies and programs might successfully strengthen marriage as an institution among low-income populations as well as among a wide variety of ethnically and culturally diverse populations, our national focus should be on the design, implementation, and rigorous evaluation of these initiatives.
Marriage, Divorce, and Single Parenthood Encouraging and supporting healthy marriages is a cornerstone of the Bush Administration's proposed policies for addressing the poverty-related woes of single-parent households and, importantly, for improving the well-being of low-income children.
Moral Parent, Moral Child
The rationale is reasonably straightforward: About a third of all children born in the United States each year are born out of wedlock. Similarly, about half of all first marriages end in divorce, and when children are involved, many of the resulting single-parent households are poor.
For example, less than 10 percent of married couples with children are poor as compared with about 35 to 40 percent of single-mother families. The combination of an alarmingly high proportion of all new births occurring out of wedlock and discouragingly high divorce rates among families with children ensures that the majority of America's children will spend a significant amount of their childhood in single-parent households.
Moreover, research shows that even after one controls for a range of family background differences, children who grow up living in an intact household with both biological parents present seem to do better, on average, on a wide range of social indicators than do children who grow up in a single-parent household McLanahan and Sandefur, For example, they are less likely to drop out of school, become a teen parent, be arrested, and be unemployed.
While single parenthood is not the main nor the sole cause of children's increased likelihood of engaging in one of these detrimental behaviors, it is one contributing factor. Put another way, equalizing income and opportunity do improve the life outcomes of children growing up in single-parent households, but children raised in two-parent families still have an advantage.
If the failure of parents to marry and persistently high rates of divorce are behind the high percentage of children who grow up in a single-parent family, can and should policy attempt to reverse these trends? Since Daniel Patrick Moynihan first lamented what he identified as the decline of the black family in his report, The Negro Family: The Case for National Action, marriage has been a controversial subject for social policy and scholarship.
The initial reaction to Moynihan was harsh; scholars argued vehemently that family structure and, thus, father absence was not a determinant of child well-being. But then in the s, psychologists Wallerstein and Kelly, ; Hetherington, began producing evidence that divorce among middle-class families was harmful to children.
Renewed interest among sociologists and demographers Furstenberg and Cherlin, in the link between poverty and single parenthood soon emerged, and as noted above, that work increasingly began building toward the conclusion that family structure did matter McLanahan and Sandefur, Start studying Cherlin: Chapters 11,12,13, Learn vocabulary, terms, and more with flashcards, games, and other study tools.
Family and Relationships: A Culture of Divorce
b. the wisdom of imposing a particular moral view of family life on people with other lifestyles One of the most consistent findings of the research into the effects of divorce is that A) mothers are often.
Divorce has implications on the values and morals of Filipinos which can be shown by giving the positive and negative effects of divorce on the family affected by the process. Divorce (or the dissolution of marriage) is the final termination of a marital union, cancelling the legal duties and responsibilities of marriage and dissolving the bonds of matrimony between the parties.
The different direction in the findings for the recipient and applicant groups explains the absence of an overall effect on divorce. And in both cases, the effects we did see were small — about a 3 to 4 percentage point difference in divorce between the MFIP group and the AFDC group.
Finally, recall that public marriage and divorce records can capture only a family's legally documented marital status. Jul 02, · T hese days there is once again a great deal of hand-wringing about the sorry moral state of America's children.
All the usual suspects have been rounded up: parents who lack values, schools that neglect "character" education, and -- conservative pundits' favorite culprit -- family breakdown.
Divorce is altering the institution of marriage and family in ways not yet fully comprehended.
However, enough is understood to allow experts in the field to state that increased tolerance of divorce has produced profound changes in our attitudes toward what we think marriage and family to be. Values are what bring distinction to your life. For more about the effects of divorce and remarriage on adolescents, see my novel, "THE CASE OF THE SCARY DIVORCE -- A Jackson Skye Mystery.
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« Momma's Home! CONQUEROR WOMB Now Available for Purchase!
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On average, teachers in St. Johns County spend $600 of their own money on school supplies for their students and classroom. Tools 4 Schools supports these needs by accepting donation from local businesses and community citizens and shares them with teachers throughout the year.
In a friendly competition that held no losers, The Bailey Group challenged Kresge, Platt & Abare to collect the most supplies.
Hydro Aluminum scrambled with Carlisle Interconnect Technologies to do the same. The result was a harvest of supplies for local teachers and students.
"We are proud to partner with the St. Johns County Education Foundation to support children and teachers in our community," said Carrie Gainor, community service chairperson of Hydro Aluminum. "Hydro team members take pride in this annual event, and this year donated an astonishing 14,000 items. We look forward to next year's school supply drive."
Staff and volunteers made their rounds to collection sites on a public school bus. Volunteers unloaded and sorted the supplies at the permanent storage facility - The Bailey Group Resource Depot sponsored by The Bailey Group.
Teachers submit a supply request for items needed in their classrooms. The orders are then processed, filled and delivered to teachers. The permanent depot allows Tools 4 Schools to be a continual resource for teachers.
"An opportunity to get free school supplies, courtesy of local businesses and community citizens, attracted a number of school teachers to our website to request supplies," said Donna Lueders, executive director of SJCEF. "We are grateful for the community's help in stocking the Depot."
To learn how you can support our students and teachers, go to www.getonthebusstjohns.org.
Business participants included The Bailey Group, Baker Pest Control, Beaver Toyota, Bozard Ford, Carlisle Interconnect Technologies, Community First Credit Union, Cowan Financial Group, Dennis Hollingsworth Tax Collector, Discount Grocery, First Atlantic, Flagler College, Flagler Hospital, FPL, Herbie Wiles Insurance, Hydro Aluminum, Kiwanis Club, Kresge, Platt & Abare, Leonard's, Nissan of St. Augustine, Northrop Grumman, Prosperity Bank, Regions Bank, St. Augustine Record, St. Augustine Lighthouse & Museum, South Beach Grill, Switzerland Community Church, United Way of St. Johns County, Vystar Credit Union, and World Golf Hall of Fame.
The St. Johns County Education Foundation is recognized as the direct support organization for the St. Johns County School District.
The foundation leads efforts to provide funding opportunities, support initiatives that enhance public education and recognize and inspire teachers and students within St. Johns County.


The First Step to a Successful Divorce is to Hire the Right Divorce Lawyer!
Being that this entire book is devoted to helping you hire the best divorce lawyer shows you just how important it really is and how difficult it can be if you do not have the proper guidance. Your lawyer will be your teammate to help you through what can be a very difficult time, so do yourself the favor and spend the time up front to prepare yourself to make the first and probably the most important decision of your future. The total cost of the book is $22.95.
1. They use a lawyer who does not have a focus on family law.
2. They use a relative who is a lawyer.
3. They ask a friend for a referral.
4. They start calling out of the yellow pages.
You more than likely never thought you would even be in this situation with your marriage, let alone having to seek legal help to get your marital issues resolved. Sit back a relax a little and let this guide book show you exactly what you need to do to take the first step in the right direction. No matter what you decide, do not go into your divorce without having a good plan with an experienced divorce lawyer. Almost ever person who has a bad experience with their divorce will blame it on his or her lawyer. Do not let this happen to you.
How to Hire the Right Divorce Lawyer will not only provide instruction on how to obtain the best lawyer for your situation, but it also includes the information you need to work effectively with the lawyer you choose. These sections are devoted to your relationship with your lawyer and will help you save hundreds in legal fees and improve the chances of a favorable outcome.
1. How the Legal System Operates in Divorce & Custody Cases.
2. Searching for the Right Divorce Lawyer.
3. What to Do and Ask at the First Appointment.
4. Top Attributes to Look for in a Divorce Lawyer.
5. Understanding Your Lawyer�s Billing Terms.
6. Communicating Effectively with Your Lawyer.
7. The Mistakes that Clients Make.
8. When and How to Fire Your Lawyer.
13. Comprehensive Divorce Dictionary of Legal Terms.
Do not let yourself or your children be a victim of the courts. This book provides the knowledge needed to evaluate the strengths and weaknesses of available divorce lawyers and then help syou pick the best one for you and/ or your children to get through the divorce in the best possible fashion.


Sometimes, if it was not a school night, my mother would suggest that we go "window shopping" after dinner. We would hasten to clear the table and clean up the kitchen, then the three of us would get in the car and drive to nearby Westwood Village or further afield to Beverly Hills or Hollywood.
There we strolled, pausing in front of store windows and commenting on the clothes or the mannequins or the other objects on display. I never seemed to tire of running up the sloped ramp of the Frank Lloyd Wright-designed Anderton Court Shops or fitting my small feet into the stars' footprints at Grauman's Chinese Theatre.
If these trips were aids to digestion, they could hardly be called exercise. Yet without any overt teaching, they were always a lesson in observation, in seeing: color, shape, texture, design. And it was something we did together, without conflict and with little emotional demand, bringing home bellies happy with ice cream and recollections to fuel imagination.
In honor of Valentine's Day, fifteen couples will share expressions of love and all its entanglements this evening at SpeakEasy 13: Love Uncensored. Please join us at 7:00pm in the Mount Baker Theatre Encore Room in Bellingham, Washington. Free (donations appreciated). Adults only, please.
A couple of months ago, by way of a random Facebook post, I learned of the very sudden, too-soon death of a dear friend. I met Ira in the 1970s, when we both lived in Seattle, and again in the 80s, when we both lived in Los Angeles. For most of the years since, he had lived in Israel. Our contact was occasional, by e-mail or on Facebook, but always with the warmth of old friends. I was — am still — stunned and saddened by his death.
Yesterday, unbidden, this memory of Ira popped into my head. It was 30 years ago: 1984. It was a time when surgery meant you stayed in the hospital for some days, and that's where I was. I felt emotionally and physically depleted and sort of afraid of myself — of the tubes dripping into my arm, the staples holding me together — as if at any moment I might leak or tear or break into pieces.
I didn't really want to see (or, more to the point, be seen by) anyone, had left instructions for friends not to visit, and mostly they hadn't. But not Ira. He showed up with his big smile, slipped off his shoes, crawled right into the hospital bed with me and gave me the biggest hug. He didn't treat me like something fragile or dangerous. Disheveled, unfamiliar to myself, I was, to Ira, simply his friend.
It may have been one of the sweetest things anyone ever did for me and it makes me so, so sad to know that he's no longer in the world. Thanks, Ira.


I though Lewis Black was a comedian. When did he become a preacher? Im offended that he compared that to Vietnam. He really went full retard with that comment.
This made me laugh the other day!
I've been laughing all day!


Peter Bakker, President and CEO of the World Business Council for Sustainable Development (WBCSD), was today ordained Officer of the Order of Orange-Nassau, in recognition of his long-lasting commitment to engaging business in tackling global sustainability issues. Peter received the decoration on the occasion of the 72nd anniversary celebrations of Nyenrode Business University, from the Mayor of Stichtse Vecht, on behalf of HM King Willem Alexander of the Netherlands.
Geneva, 20 November 2018: Peter Bakker, President and CEO of the World Business Council for Sustainable Development (WBCSD), was today ordained Officer of the Order of Orange-Nassau, in recognition of his long-lasting commitment to engaging business in tackling global sustainability issues.
Mr Bakker received the decoration on the occasion of the 72nd anniversary celebrations of Nyenrode Business University, from the hands of Yvonne van Mastrigt, the Mayor of Stichtse Vecht, on behalf of HM King Willem Alexander of the Netherlands. Among those present were Mrs. Neelie Kroes, former rector of Nyenrode, Herna Verhagen, CEO of PostNL and various other prominent figures.
In his keynote, Peter explained the connection between the dream of the founders of Nyenrode – to make the Dutch economy flourish – with the challenges of global sustainability. The importance of this dream and the challenges it presents are just as great in 2018 – and possibly even more complex – than already recognized in 1946. The society in which we live will go through unprecedented transformations in the next 15 years – "business must take a leading role in managing these changes. We are well beyond philanthropy and CSR. It's time to brutally confront the facts of our own business models and act to make them sustainable" he stated. In return, this will lead to untapped new opportunities for business. The definition of what a flourishing economy is will have to change by integrating societal and environmental performance into the Cost of Capital for business.
Peter Bakker is Chairman of War Child in the Netherlands and serves as a member of corporate sustainability advisory boards. He has been a recipient of the Clinton Global Citizen Award (2009) and the Sustainability Leadership Award (2010).
In 2012, Peter Bakker became President and CEO of WBCSD in Geneva, Switzerland. WBCSD is a global, CEO-led organization of over 200 leading businesses working together to accelerate the transition to a sustainable world. WBCSD member companies come from all business sectors and all major economies, representing a combined revenue of more than USD $8.5 trillion and with 19 million employees.


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Listen to a New Album Featuring Tom Waits Songs in Hebrew (2013)
in Music | November 15th, 2013 1 Comment
Tom Waits is a rare breed of performer, having attained vast commercial success without having had to pander to a mass audience. His gruff voice—the vocal equivalent of too many late nights, strong scotch, and a pack-an-hour habit—has become the hallmark of a sort of grimy, outsider cool favored by Jim Jarmusch and John Lurie. His career, which has spanned four decades and includes theatre, film, and the iconic interview that inspired the character of The Joker in The Dark Knight, is the envy of most musicians. It was only fitting, considering his prodigious output, that Waits would become the subject of a cover album. Unsurprisingly, it comes with a twist—it's in Hebrew.
Heeb Magazine recently posted a link to "Shirim Meshumashim" ("Used Songs"), producer Guy Hajjaj's four-year project where Israeli musicians recreate Tom Waits' back catalog. The 22-song album draws widely from Waits' career, including songs from classic albums such as Raindogs (1985) as well as the more recent Orphans: Brawlers, Bawlers & Bastards (2006) and Glitter and Doom Live (2009). While more zealous fans will undoubtedly claim that Waits' original delivery can never be matched, those with an open mind will likely find a number of gems. Some of our favorites include "Clap Hands," ideally suited to Hebrew's harsh, gravelly sounds, and the lighter, yet unmistakably Waits-written, "Dirt in The Ground."
You can stream the album above, or buy the album (downloadable on a pay-what-you-wish basis) here.
Via Heeb Magazine
Tom Waits' Classic Appearance on Australian TV, 1979
Tom Waits Reads Charles Bukowski
The Black Rider: A Theatrical Production by Tom Waits, William S. Burroughs & Robert Wilson (1990)
Davey B says:
I am absolutely loving this. I'll admit that if you don't understand Hebrew, this may not appeal to you as much. The translation is spot on though. I'd love to see this done with other American artists as well. They do this with musicals and its cool to see that they're taking this beyond Broadway.