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", "Contact Us"); }; $(function () { $('body').on('click', '.goAlert', function () { if (!$(this).hasClass('noalert')) { goAlert(); }; }); }); Web Design #58610 Customized Website Cafe Apple Butter Custom Website Development & Web Hosting
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Contact us today to learn more about this fully customizable live demo website which is populated with demonstration website content to fully showcase this design. Therefore, the apple can be placed in hot jars without chances of compromising quality of the product. Our website development service includes 12 months of business grade email service for your entire staff using your domain name. Your choice of email platforms including ZOHO, Gmail, Outlook many more. The pressed apple cider and cooked apple puree are added to a large steam vat. Our development service includes custom scripting. Our website development service includes an integrated content management system including a fully customized version of CKEditor. This storage method does not destroy pre-existing microorganisms that may be present in the product, so it is important to be wary when consuming previously product. Applying high temperatures over a specified period of time can not only aid in the sterilization of the jars or cans used in packaging, but it can help maximize the storage time of the apple butter or other products. The heat used for this method of canning can be sufficient to kill bacterial cells found the food. Our website development service includes Admin Tools: A browser-based platform that makes it easy for you to manage aspect of your website. Website Designer Cafe Chicken Sandwich
Our website service includes a fully integrated Events Calendar with interactive signups. Small amounts of sodium bicarbonate are to the mixture in order to reduce acidity and help bring out sweetness from the natural fructose available in the apples. The spoilage microorganisms in acid foods can be destroyed in a small amount of time at temperatures below that of boiling water, so there is little risk of microorganisms appearing in the food product itself. Freezing jars of apple butter can help to maintain quality and inhibit bacterial growth. It is produced in apple-growing regions such as Nagano and Aomori Prefectures and often uses local apple varieties such as Fuji. Apple butter can be used as a fat substitute in reduced-fat or fat-free cooking, as well as vegan recipes. Apples (peeled, cored, finely chopped) Brown (or white) sugar or unrefined sugar beet juice Apple juice (or apple cider) Spices (nutmeg, cloves, allspice, cardamom, vanilla extract and lemon juice – optional.) Different types of apples can be used for the production of apple butter. Apples are a high acid food, a pH below 4.6. The Pennsylvania Dutch often include apple butter part of their traditional 'seven sweets and seven sours' dinner table array. The most popular one is made from apples, but povidlo is also made from apricots, cherries, prunes, and cranberries. Apple butter is a highly concentrated form of sauce produced by long, slow cooking of apples with cider or water to a point where the sugar in the apples caramelizes, turning the apple butter a deep brown. Website Developer Restaurant Guatemalan Cuisine
Our website development service a fully integrated localized search engine. Our website development service includes cart and e-commerce integration featuring a variety of payment solutions including DASH, Paypal, Bitcoin, Authorize.net and many more. Our website development service includes upgrading your website or creating a new custom website for your business. Nevertheless there are numerous methods that can be used for storage of apple butter. Our website development service includes site-wide SSL certificates that never expire and can be used to encrypt and secure your entire with the HTTPS protocol. Our development service includes integration of your new and existing website content into your new design. Our development service includes integrated blogging software using the provider of your choice (ie Blogger, WordPress, etc.). Our website development service includes an offsite disaster recovery for the entire website server. Diner Website Designer
Other than in Benelux and the Rhineland, apple syrup is a minority taste in Western Europe (in Germany, outside of the Rhineland, it is generally sold in health food shops), and a similar food is in francophone Switzerland, where it is known as vin cuit . Russian Пови́дло (from Czech povidla , or Polish powidła or powidło ) is prepared by the reduction of fruit puree with some sugar and sometimes spices. Our website development service includes fully responsive CSS coding ensure that your website passes Google's latest mobile friendly tests. Our website development service includes integration of contact systems such as Constant Contact and iContact. Due to its high acidity, high sugar content and low amounts of free water, an opened package can be kept for months room temperature without spoiling. Our website development service includes customizable website design suggestions. Boiling the jars will the oxygen remaining in the jar, which forms a tight seal between the lid and the rim. Our website service includes social networking integration (Facebook, Twitter, LinkedIn, etc.) This is because high-acid foods prevent the growth of spores of the bacterium Clostridium botulinum , which can't killed by boiling. Restaurant Canadian Cuisine Website Programmer
Soft apples are often chosen for the production of apple butter because they can be broken down more and faster when cooked. These types of apples include: McIntosh (soft, creamy), Cortland (soft, sweet-and-tart, all-purpose), Granny Smith (tartness sweetens upon cooking, complement to savory and salty foods). Apples are first selected based on ripeness, texture, natural sweetness and tartness/acidity. Large paddles were used to stir the apples, and family members would turns stirring. Our website development service includes automatic daily of your website files. The mixture will then be boiled during the evaporation process, allowing volume to reduce to one seventh. Our development service includes domain name registration tips and assistance. The end product will be a concentrated mixture used as apple butter. Apple butter typically packaged in the same way whether it is prepared in a factory setting or made at home. Our website development service includes months of managed high speed hosting on a secure server in a world class data center.
Our development service includes cross browser checks to ensure that your website looks great and functions correctly on all types of devices. Our website development service advanced photo gallery tools which can be used to create stunning photo galleries of all sizes, in minutes. Apples are based on their physical and chemical properties – such as hardness, sweetness, acidity/tartness, etc. Our website development service includes advanced video embedding tools which can automatically synchronize with your YouTube channel display all of your videos on your website. Our website development service includes creation of simple (or complex) online forms. The final product should contain no than 34% of moisture and about 60% of sugar. Polish powidła are made from fresh purple plums and with addition of sugar. In Jersey, in the Channel apple butter is known as black butter or lé nièr beurre and includes liquorice as an ingredient. In Japan, apple butter often contains actual butter and is a considerably lighter in color, typically a shade of yellow. Our website development service custom programming. Cafe Chicken Sandwich Web Development
Traditionally, butter was prepared in large copper kettles outside. Our website development service includes consulting and assistance your pay-per-click and other third party advertising campaigns. Our website development service includes Flash elements into search engine friendly assets, as needed. Only high-acid food with a pH of 4.6 or can be processed using the boiling water bath method. Payment plans are available for qualified Please ask for details. In performing SEO, we adhere to the guidelines published by Google. Our website development service includes consultations as needed to identify your current future website goals. No method is 100% dependable, as there is always a of the presence of bacteria or other microorganisms within the food itself, on the storage equipment or in the storage facility. Typically, the jars are sterilized before packaging to ensure no harmful microorganisms or bacteria will infect the product, causing it to spoil. Website Design Cafe Chicken Sandwich
In areas of the American South, the production of apple butter is a family event, due to the large amount of labor necessary to produce apple butter large quantities. Our website development includes comprehensive and easy-to-read website statistics. Apple butter is also used on a sandwich to add an interesting flavor, but is not as commonly used as in historical times. Vinegar or lemon juice is sometimes mixed in while to provide a small amount of tartness to the usually sweet apple butter. The production of apple butter was also a popular way of using apples in colonial America, well the 19th century. The product contains no actual dairy butter; the term butter refers only to the butter-like thick, soft consistency, and apple butter's use as a spread for breads. Our website development service includes the ability to create Member Only content, quickly and easily. Our development service includes graphic design and logo enhancement services. The main sources of spoilage, yeasts and enzymes, are killed at the temperatures reached in the hot water bath during the sterilization process for cans and jars. Ideally, jars are sterilized using a combination of high temperature heating and ensuring a seal. Restaurant Capocollo Web Developer
Our website development includes a fully integrated e-commerce platform for selling products and services directly through your website (PCI compliant solution). In Appalachia, apple butter was the only type of fruit preserve normally rendered into fruit leather. In Europe, an apple butter is traditionally made which is closer to dense syrup, in the Netherlands (known as appelstroop , meaning apple syrup ) and in Germany (known as apfelkraut ) and frequently eaten on bread (or without) thinly sliced cheese and with Sauerbraten . Our website development service includes contact collection and contact management system (CMS) bulk emailing capability for newsletters, events, promotions, etc. A sweeter version, using pears, as well as apples, is more popular in Belgium, where it is known as sirop de Liège . Our website development service includes 12 months of upgrades seamlessly applied to your website and email system. The production of the butter was a way to conserve part of the fruit production of the monasteries in that region, at a time when almost every village had its own apple-butter producers. Our website development service includes targeted search optimization (SEO) for your entire website. Some of these apples are pressed into fresh cider, while the rest are peeled and cored, then wholly steamed and cooked into apple puree. Custom Website Tasting Menu
The concentration of sugar gives apple butter a much longer shelf life as a preserve than apple sauce. The roots of apple butter lie in Limburg (Belgium and the Netherlands) and Rhineland (Germany), conceived the Middle Ages, when the first monasteries (with large orchards) appeared. Our website development includes 12 months of regularly scheduled consultations including proactive recommendations for improving your website. A master website developer will work with you to achieve your immediate websites goals including the development of your new website design and the creation of numerous website pages. Your developer will also show you how to create unlimited additional pages with ease using the built-in content management system (CMS). In addition, you will 12 months of full service including high speed managed hosting, effective search engine optimization (SEO), detailed website statistics, and much more. Sometimes seasoned with cinnamon, clove, and other spices, apple butter is usually spread on bread, used as a side an ingredient in baked goods, or as a condiment. It is used as a spread on toast or as a filling in baked buns, and may consist of a mashed texture with small apple chunks, similar to the red bean filling used in anpan. It can be packaged mechanically in jars or through the use of machinery. Apple butter is a product created as a means of preserving apples. Our website service includes custom database services. Our development service includes selecting high quality images for your website with your approval and input.


The application process is quick and easy. The BLS accepts applications year-round, but with rolling deadlines for each exam.
An individual becomes eligible for the exam by meeting specific requirements as determined by the Board of Laser Safety for the jurisdiction for which they are applying.
The following tabs summarize these requirements for each jurisdiction and provides resources to help you prepare for the LSO Examination application process.


Epic Games released a new Halloween patch that vastly improves the multiplayer Battle Royale game mode.
It has been exactly a month since Epic Games entered the gaming scene with their hugely popular free-to-play online multiplayer mode called "Battle Royale." This Game Mode drops 100 players onto an island with a last man standing approach, and the genre has seen some great exposure over the past year with the release of "Player Unkown's Battlegrounds."
What's new for console players?
Console users will see the most benefit from this update as the patch refined the controls and made every aspect of the game feel much more fluid and less clunky.
The new "Combat Pro" controller configuration aims to keep the players' thumbs on the joysticks as much as possible, whilst changing between items and building materials is much more efficient now and console players can now master and hone their skills. This update alone is a game-changer and will only increase the skill gap.
Another notable change is the addition of the in-game voice chat functionality for Xbox One and PlayStation 4. After jumping on earlier for a test of the new update, I was pleasantly surprised with the improvements they made to combat the sever frame-rate issue that was turning a lot of players away from the game in the past week or two.
A 30 FPS cap was re-enabled on the PS4 and PS4 Pro to maintain a smooth experience.
Overall players on Xbox and PlayStation should notice the dramatic improvements in gameplay, and although not quite perfect and as smooth as PC, it certainly is a big step in the right direction.
What else can players expect?
The most exciting addition is the new progression and leveling-up system which rewards players for playing and gaining XP after they hit a certain level. Daily challenges provide players an opportunity to gain this XP faster, and hopefully we will be seeing more than one daily challenge in the future.
Customization options are now available for your character as well. These new cosmetics can be equipped from the brand new Locker menu. Another feature added is the ability to create and showcase your own banner, however the customization options remain basic, letting players only choose a logo and background color.
A regeneration potion called "Slurp Juice" has been added to the game that grants 1 health and 1 shield per second for 25 seconds. While running around the map, players will now automatically pick up items such as traps, ammo and building materials which is a very good quality of life update.
Brand new Halloween skins can be found on sale in the new item shop. V-bucks is the new currency for "Fortnite," letting players buy character and weapons skins from the item shop.
Sadly, all player settings have been reset, and Epic Games have said they are working on improving this problem going forward.
To read the full list of patch notes in more detail see the official blog of Epic Games.


LOOKING FOR THAT NEXT UNIQUE RARE ITEM? WELL LOOK NO FURTHER! CARRIE FISHER OWNED STAR WARS: A NEW HOPE ORIGINAL FRAMED SCRIPT PAGE! THIS IS YOUR OPPORTUNITY TO OWN A VERY RARE PIECE OF STAR WARS HISTORY!! AS DIE HARD STAR WARS COLLECTORS & FAITHFULS KNOW, MEMORABILIA FROM ANY OF THE MOVIES IS HIGHLY COLLECTIBLE AND ANY SORT OF MOVIE PROPS OR PERSONAL ITEMS THAT HAVE DIRECT RELATION TO STAR WARS MOVIES AND OWNED BY EITHER THE MAIN ACTORS OR PRODUCERS ARE ALMOST IMPOSSIBLE TO FIND! GEORGE LUCAS WAS NOT BIG ON KEEPING MOVIE PROPS FROM HIS STAR WARS MOVIES SO THERE ARE NOT MANY OUT THERE IN EXISTENCE WHICH IS WHY UNIQUE PIECES LIKE THIS ARE SO HARD TO FIND AND RARELY HIT THE OPEN MARKET. NOW IS YOUR CHANCE TO OWN A PIECE OF CINEMATIC HISTORY!
THIS COLLAGE FEATURES AN ACTUAL SCRIPT PAGE FROM A "STAR WARS: A NEW HOPE" MOVIE SCRIPT PERSONALLY OWNED BY ACTRESSES CARRIE FISHER WHO PLAYED PRINCESS LEIA IN THE MOVIE SERIES!! THE SCRIPT WAS PROCURED DIRECTLY FROM CARRIE FISHER & DEBBIE REYNOLDS' (HER MOTHER) ESTATE AFTER HER DEATH AND THIS MARKS THE FIRST TIME EVER, YOU CAN OWN AN ACTUAL PAGE FROM HER STAR WARS SCRIPT!!! THIS FRAMED COLLAGE IS LIMITED TO ONLY 100 EVER MADE AND NO MORE WILL EVER BE PRODUCED, ONCE THEY ARE GONE, THEY ARE GONE FOREVER! EACH CUSTOM COLLAGE IS INDIVIDUALLY LASER ENGRAVED ON THE NAMEPLATE WITH IT'S OWN SPECIFIC NUMBER IN THE 100 LIMITED EDITION RUN. SEE PHOTOS. NO COPIES WILL EXIST OF EACH SCRIPT PAGE AND YOU WILL BE THE RIGHTFUL OWNER OF THAT SPECIFIC SCRIPT PAGE FOREVER. THE SCRIPT HAS BEEN CUT AND SEPARATED INTO INDIVIDUAL PAGES AND PROFESSIONALLY CUSTOM FRAMED FOR THE ULTIMATE STAR WARS COLLECTOR!! THIS SPECIFIC LISTING IS FOR A RANDOM PAGE THAT DOES NOT INCLUDE A PRINCESS LEIA SPEAKING LINE ON THE PAGE DISPLAYED. THIS WILL BE FOR A PAGE THAT HAS OTHER CHARACTERS' SPEAKING LINES BESIDES "PRINCESS LEIA".
IF YOU WOULD LIKE TO PURCHASE A PAGE THAT DOES INCLUDE A SPEAKING LINE / DIALOGUE OF PRINCESS LEIA, IT IS AN ADDITIONAL $100 COST AND YOU CAN SEARCH OUR ONLINE STORE FOR A SEPARATE LISTING FOR THIS SPECIFIC PRODUCT. WE ALSO HAVE PREMIUM PAGES AVAILABLE WHERE IT IS THE FIRST PAGE OF THE SCRIPT, LAST PAGE OF THE SCRIPT, #D1/100 OR #D100/100, FIRST AND LAST APPEARANCES OF HER CHARACTER IN THE SCRIPT, ETC. PLEASE CONTACT US DIRECTLY TO INQUIRE FOR THOSE SPECIAL PAGES. CONTACT US IMMEDIATELY AS WE ARE EXPECTING TO SELL OUT OF ALL 100 PAGES ALMOST IMMEDIATELY FOLLOWING THE RELEASE OF THIS RARE COLLECTIBLE!
REMEMBER THE SCRIPT PAGE YOU RECEIVE WILL BE RANDOM. EACH SCRIPT PAGE WILL COME WITH A LETTER OF AUTHENTICITY FROM INSCRIPTAGRAPHS MEMORABILIA, GUARANTEEING THE PAGE IS AUTHENTIC. ON THIS LETTER, YOU WILL SEE AN ACTUAL PICTURE OF THE PAGE IN QUESTION AND PAGE NUMBER TO DIRECTLY CORRELATE THAT PAGE TO THIS LETTER OF AUTHENTICITY. THE ITEM ALSO INCLUDES A COPY OF THE ORIGINAL CERTIFICATE OF AUTHENTICITY (ON THE BACKSIDE OF THE LETTER) ISSUED BY TODD FISHER, CARRIE'S BROTHER, WHO HAS PRESIDED OVER THE SALE OF PERSONAL ITEMS FOR HER AND HER MOTHER, DEBBIE REYNOLDS' ESTATE. TODD SIGNED THE ORIGINAL PAPER GUARANTEEING THAT THE SCRIPT IS AUTHENTIC, WAS OWNED BY CARRIE FISHER AND DIRECTLY FROM HERS AND HER MOTHER'S ESTATE. IT DOES NOT GET ANY BETTER FOR AUTHENTICITY PURPOSES THAN OWNING AN ITEM DIRECTLY FROM HER ESTATE.
THIS SCRIPT PAGE HAS BEEN PROFESSIONALLY CUSTOM FRAMED WITH MUSEUM QUALITY FRAMING MEASURING 19" X 36" IN SIZE THAT FEATURES A BLACK SLATE DESIGNER WOODEN FRAME. IT FEATURES 2 UNSIGNED 8X10 PHOTOS OF FISHER AS PRINCESS LEIA, A SILVER NAMEPLATE DEPICTING INFORMATION ABOUT THE SCRIPT PAGE WITH IT'S INDIVIDUALLY LASER ENGRAVED LIMITED EDITION NUMBER & AN OFFICIAL STAR WARS NEW HOPE MOVIE POSTER TRADING CARD. ALSO, THIS PIECE INCLUDES CUSTOM CUT STARS THROUGHOUT THE PIECE AND A GLASS DISPLAY!
TO COMBAT DUPLICATION OF THE PAGE, WE HAVE MARKED EACH PAGE WITH A CONFIDENTIAL PROPRIETARY COMPANY MARKING TO DETER FRAUD. IN ADDITION, EACH PAGE HAS A SILVER TAMPERPROOF HOLOGRAM ON THE BOTTOM CORNER SIGNIFYING THAT THIS SPECIFIC PAGE IS AUTHENTIC AND NOT A REPRODUCTION. EACH HOLOGRAM HAS A UNIQUE CODE NUMBER ON IT WHERE YOU CAN GO ON OUR CERTIFICATE IF AUTHENTICITY DATABASE ON OUR WEBSITE AND VERIFY THE AUTHENTICITY OF THE PAGE 24/7/365.
NOTE: THIS ITEM IS EXCLUDED FROM ALL DISCOUNTS AND PROMOTIONS BEING OFFERED. ALSO, THE MAKE ON OFFER OPTION WILL NOT BE AVAILABLE FOR THIS LISTING. PLEASE ALLOW UP TO 3 WEEKS FOR PIECE TO SHIP OUT DUE TO EACH PIECE BEING MADE TO ORDER AND WILL INCLUDE A BRAND NEW FRAME AND ALL.


Pastor, Producer, Songwriter and Gospel Artist are a few of the facets of William Becton. He is most popularly known for his contributions to the gospel music industry, yet he has made waves also in Radio and in the Evangelical Community. He creatively and consistently spreads the message of Encouragement in all three venues, while fulfilling his mission to make disciples of the broken. So, tune in every Sunday for a trip down memory lane with William Becton on "Old School Sundays" from 12n-4pm on Charlotte's inspiration station…Praise 100.9!


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"Always On My Mind" by Pet Shop Boys – Disco Video Mix by Glenn Rivera
Pet Shop Boys are Chris Lowe and Neil Tennant – a duo who brought the disco beat back as though it were knew all over again in the mid-80s. Their disco remake of Willie Nelson's "Always On My Mind" is one of those initial oddities that have become a landmark and trend for the band and the period. Orchestrated and arranged with the love and power of an emotional opera.
I have taken scenes from the 1981 black comedy from John Waters – "Polyester" starring Divine and Tab Hunter and painted a loving portrait of the wonderful and loving moments form the warped and hilarious rollercoaster ride. It plays our romantically and a bit schmaltzy – but so is love!
The film was directed by John Waters
Featuring scenes from "Polyester" – RENT THD DVD!

redpajama_set_name: RedPajamaCommonCrawl


The first issue of the Journal of Chemical Documentation appeared in 1960. The name of the journal changed to the Journal of Chemical Information and Computer Sciences ("JCICS") in 1975 and to the Journal of Chemical Information and Modeling ("JCIM") in 2005.
Posted with permission from the Journal of Chemical Information and Modeling. Copyright 2010 American Chemical Society.
This year, 2010, is thus the 50th anniversary of the journal. The anniversary was marked by a symposium shared between CINF and COMP Divisions at the fall 2010 ACS National Meeting and was celebrated by an excellent reception sponsored by ACS Publications, where we all enjoyed useful networking and renewal of old acquaintances (http://pubs.acs.org/page/jcisd8/anniversary/50/index.html).
Over the fifty years of the journal there have been only four main editors (http://pubs.acs.org/page/jcisd8/anniversary/50/editors.html). Herman Skolnik (whose name is honored by the CINF Award) was the editor from 1960 to 1982. Tom Isenhour served as editor from 1982-1989, and he was succeeded by Bill Milne (1989-2004). Associate Editors were appointed in 1989: Pierre Buffet (1989-1997), Reiner Luckenbach (1989-1999), Kenny Lipkowitz (1993-2005), Tony Hopfinger (since 1993), Dušanka Janežič (since 2001) and myself (since 1989). Bill Jorgensen has been editor-in-chief of JCIM since 2005. He also edits JCIM's very successful, new sister journal, the Journal of Chemical Theory and Computation ("JCTC").
The first speaker at the 50th anniversary symposium was Johnny Gasteiger, whose first paper appeared in JCICS in 1977. Volume 46, issue 6 of JCIM in 2006 was his sixty-fifth birthday present: an issue in his honor. Johnny related how his early publication on the separation of π and σ systems (Gasteiger, G. A Representation of π Systems for Efficient Computer Manipulation. J. Chem. Inf. Comput. Sci. 1979, 19, 111–115) had devolved into a system, RAMSES, overcoming the limits of the connection table (Bauerschmidt, S.; Gasteiger, J. Overcoming the Limitations of a Connection Table Description: a Universal Representation of Chemical Species. J. Chem. Inf. Comput. Sci. 1997, 37, 705–714). The Molecular Structure Encoding system (MOSES) is a C++ toolkit based on RAMSES. Johnny also outlined his work on reactions, the most current system being THERESA; the calculation of structure descriptors (now available in ADRIANA.Code); 3D structure generation (CORINA); artificial neural networks; and biochemical pathways (BioPath). The research efforts of Johnny's team over the years have led to range of products now marketed (under the aforementioned names) by Molecular Networks (http://www.molecular-networks.com/).
Bill Milne's talk also had a historical perspective. He started by outlining the history of the journal (some of which I have given above), but his main theme was those cheminformatics problems that have been solved and those that are proving intractable. Structure drawing, substructure search, and structure codes fall into the first category. Conversion of names into structures (and vice versa) and ligand-protein binding are largely solved. Properties estimation is "somewhat solved." Much of the research in these fields has been published in the journal. Protein-protein binding requires much more exploration, and Markush searching is an open problem, according to Bill, but he did not have time to go into detail about the many papers in JCICS on the subject.
A unique aspect of cheminformatics is that it has been heavily influenced and shaped by the needs of the pharmaceutical industry. Dimitris Agrafiotis reflected on experiences of the past and explored the possibilities he saw for the industry in the future: possibilities lying in the convergence of chemistry, biology, and information technology. First he talked about the world before and after "ABCD" (Agrafiotis, D. K. et al. Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World. J. Chem. Inf. Model. 2007, 47, 1999–2014). Nowadays there are sophisticated tools for SAR analysis (Agrafiotis, D. K.; Wiener, J. J. M. Scaffold, Explorer: an Interactive Tool for Organizing and Mining Structure-Activity Data Spanning Multiple Chemotypes. J. Med. Chem. 2010, 53, 5002–5011), but ABCD goes beyond decision support, and also embraces electronic laboratory notebooks and sequence searching, for example.
The system must also go beyond discovery. Mining of electronic medical records involves handling massive amounts of data usually in SAS datasets. An ABCD plugin will address that problem, too. Pharma is an industry in stress. The good times are over; the future will be defined by in-licensing, pre-competitive collaborations, Asian expansion, a surge in biologics, the increasing roles of government and academia, translational research, public data, the open source movement, commoditization of medicinal chemistry and other functions, outsourcing, consolidation of software vendors, tougher problems, and return on investment.
In contrast, Val Gillet described some very recent research not yet submitted to JCIM (although early results will appear in Molecular Informatics). Her team has been working on applications of wavelets in virtual screening, in particular using GRID fields that model the interactions that a small molecule can make with a receptor. These fields are cumbersome to store and compare, but they can be compressed using wavelet transformation. This is a technique for representing signals by decomposing them into components: smoothed, or approximated components, and details or differences that can be ignored. Gillet's team has experimented with Harr compression (as used in JPEG) and Haar thumbnails. They have applied wavelet thumbnails (low-resolution approximations of finely sampled GRID fields) without loss of information. Val also demonstrated other applications, including the development of an alignment method to enable the comparison of the wavelet representations of GRID fields in arbitrary orientation.
Jürgen Bajorath's presentation was remarkable in that it was given remotely using Skype, because Jürgen was prevented from traveling at the last minute. This is not the first time that CINF has used this technique (the first was a presentation by Tony Williams in Salt Lake City in 2009), but it still caused some excitement. Rajarshi Guha changed the slides in Boston while Jürgen presented, with video, from Bonn, Germany.
Jürgen described some research on privileged substructures. Many privileged substructures have been proposed, but the existence of truly privileged structural motifs has remained controversial. Many scaffolds thought to be specific to a target class occur in compounds active against other types of targets. Jürgen's team investigated whether molecular scaffolds do exist that exclusively occur in ligands of individual target families. They used Bemis-Murcko scaffolds, carried out systematic data mining of publicly available compound data (BindingDB and PubChem) and defined target communities on the basis of ligand-target networks. The nodes were targets, the edges target pair sets, and the edge width the number of shared compounds. In 18 target communities, 206 diverse hierarchical scaffolds were identified, each represented by at least five compounds, that exclusively bound to targets within one of the target communities. In contrast, most scaffolds that exclusively bind to a single target within a community are only represented by one or two compounds in public domain databases. A subset of community-selective scaffolds displays a notable tendency to produce compounds with different target selectivity. The analysis was extended to ChEMBLdb and it was found that BindingDB and ChEMBLdb contain complementary target and scaffold information.
Peter Johnson spoke next, describing work on automated retrosynthetic analysis carried out by workers in Leeds together with SimBioSys and Pfizer. Many systems for computer aided organic synthesis design were developed in the last century (LHASA, SYNCHEM, IGOR, EROS, WODCA, SynGen, etc.) but none has achieved significant user acceptance, partly because such systems required manual creation of reaction knowledge bases, a time - consuming task that requires considerable synthetic chemistry expertise. ARChem (a program developed by Peter and his co-workers) circumvents this problem by automated abstraction of transformation rules from very large databases of specific examples of reactions (Law, J. et al. Route Designer: a Retrosynthetic Analysis Tool Utilizing Automated Retrosynthetic Rule Generation. J. Chem. Inf. Model. 2009, 49, 593–602).
Mapping reactions and finding the initial reaction core are solved problems; the hard part is extending the core to non-reacting atoms. Identifying the precise structural characteristics of each reaction often requires knowledge of the reaction mechanism. Another challenge is minimizing the combinatorial explosion inherent in automated multistep retrosynthesis. One process involved in that is removing interfering functionality. This can be done using statistics on functional groups derived from reaction databases. Peter's team has been working on optimum constraint of the extended core and reducing, rather than increasing the number of rules derived by ARChem; chemists can be used to generate meta rules for reaction mechanisms. Peter concluded by illustrating some other improvements to ARChem, such as ordering of search results, which matter to the user, but do not represent great technical advances.
Like many of the speakers, Michael Gilson has been on the editorial advisory board of JCIM, but Michael's talk in the anniversary symposium was more related to JCTC than to JCIM, and indeed the work presented has been published in JCTC (Gilson, M. K. Stress Analysis at the Molecular Level: a Forced Cucurbituril-Guest Dissociation Pathway. J. Chem. Theory Comput. 2010, 6, 637–646). Michael presented molecular dynamics simulations consistent with long-ranged entropy effects throughout a protein upon binding a peptide, and explained why the concept of mechanical stress may be useful in thinking about such effects. His results suggest that computational stress analysis can provide mechanistic insight into supramolecular systems.
Elizabeth Amin also presented the results of some recently published research, this time published in JCIM (Chiu, T.-L. et al. Identification of Novel Non-Hydroxamate Anthrax Toxin Lethal Factor Inhibitors by Topomeric Searching, Docking and Scoring, and in Vitro Screening. J. Chem. Inf. Model. , 2009, 49, 2726–2734). The lethal factor (LF) enzyme is secreted by Bacillus anthracis as part of the anthrax lethal toxin. To date, no LF inhibitor is available as a therapeutic or preventive agent. Amin's team has identified five promising novel LF inhibitor scaffolds with low micromolar inhibition, using topomeric shape-based searching techniques.
Tudor Oprea addressed the issue of "druglikeness." He and Oleg Ursu have used extended connectivity descriptors computed by the Morgan algorithm and extracted them as SMARTS queries. In a method rooted in the information gain concept, already applied to derive selection rules in decision trees, they aimed at a better separation between drugs and non-drugs (Ursu, O; Oprea, T. I. Model-Free Drug-Likeness from Fragments. J. Chem. Inf. Model. 2010, 50, 1387–1394). The most discriminating atom environments (having the highest information gain) were selected as model-free druglike filters.
Tudor concluded, however, that there is a danger in relying indiscriminately on machine learning techniques that artificially separate drugs from non-drugs, especially in regard to the Available Chemicals Directory (ACD). This is likely to influence the usefulness of such classifiers negatively, as 40% of the "non-drugs" are similar to drugs. Oprea uses the term "model-free" to emphasize the fact that his method does not use kernel functions and does not force ACD into a negative label, but he admits that any learning process actually relies on models. Ultimately, "druglikeness" is defined by regulatory agencies and cannot be predicted. Oprea defined three difficulties: the drug dataset is small (some people claim that there are 8,000 drugs, but Tudor can find only 3,800); the drug character of molecules changes over time as withdrawn from the market; and drugs have high heterogeneity (from lithium to cyclosporine).
Alex Tropsha talked about "chemocentric informatics," or enabling bioactive compound discovery through structural hypothesis fusion. The information resources available to us have broadened dramatically, including large chemical genomics databases (e.g., ChEMBL, PubChem, PDSP, ToxCast), digital libraries (e.g., PubMed), gene expression profiles (e.g., cmap), and others. To address some of the limitations of QSAR models, Alex suggests adding cheminformatics to "omics." He described the use of digital libraries (Baker, N.C.; Hemminger, B. M. Mining connections between chemicals, proteins, and diseases extracted from Medline annotations. J. Biomed. Inform. 2010, 43(4), 510-519) for establishing new datasets to analyze the relationships between chemical structure and biological activity. Alex' team has transformed assertional metadata into a database for modeling toxicity (Rodgers, A. D. et al. Modeling Liver-Related Adverse Effects of Drugs Using kNearest Neighbor Quantitative Structure-Activity Relationship Method. Chem. Res. Toxicol. 2010, 23(4), 724-732).
Data curation, however, is vital (Fourches, D.; Muratov, E.; Tropsha, A. Trust, but Verify: on the Importance of Chemical Structure Curation in Cheminformatics and QSAR Modeling Research J. Chem. Inf. Model. 2010, 50, 1189–1204). Alex illustrated how computational models help in detecting and correcting erroneous data, and he described a study combining QSAR modeling, virtual screening, text mining, and gene expression profiling for identifying novel, experimentally confirmed, high-affinity GPCR ligands as potential anti-Alzheimer drug candidates. He concluded that both chemical and biological data in integrated databases should be carefully curated, that QSAR models have the power of correcting erroneous biological data, and that structural hypothesis fusion and focused experimental validation afford opportunities for drug (re)profiling.
Bobby Glen's talk also covered drug discovery. He first used Zomig to exemplify some of the issues of drug delivery, safety, and efficacy. One is solubility. Both predicting and measuring solubility are difficult problems. Bobby illustrated this fact with literature examples and with some work of his own team using random forest. So, they adopted a reliable, reproducible method to create a "standard" dataset of solubilities. Bobby described the protocol in some detail. This work was so important that they collaborated with JCIM to produce a solubility challenge, the results of which were published in Hopfinger, A. J. et al. Findings of the Challenge to Predict Aqueous Solubility. J. Chem. Inf. Model . 2009, 49, 1–5.
A second challenge is metabolism. Understanding the pharmacokinetics of drugs is very important. Metabolism can alter activity (for example, from antagonist to agonist), deactivate drugs, convert pro-drugs into active forms, produce toxic compounds, and create environmental toxins. Bobby developed a method (MetaPrint2D, available on the Web) using circular fingerprints to predict the sites and products of metabolism.
Bobby's third topic was new targets. One that interests him is apelin, a GPCR which is a difficult target and has interesting pharmacological effects. The group replaced each of the amino acids by alanine and looked at the changes in the biological activity. They also constructed cyclic peptides and used NMR to study the shape of the peptides. Analysis was done with replica exchange molecular dynamics. A beta-turn at the RPRL motif was important for binding affinity (Macaluso, N. J. M.; Glen, R. C. Exploring the RPRL' Motif of Apelin-13 through Molecular Simulation and Biological Evaluation of Cyclic Peptide Analogues. ChemMedChem 2010, 5(8), 1247-1253). Analogues were synthesized, pharmacophores were generated, and molecular dynamics was used to study them. The group then attempted to make an antagonist by stabilizing the antagonist conformation and they designed linkers to the allosteric binding site. A competitive antagonist is currently being evaluated in disease models.
The symposium concluded, appropriately, with a presentation by JCIM's most prolific author Peter Willett (http://pubs.acs.org/page/jcisd8/anniversary/50/most-prolific.html). Peter talked about weighting and fusion methods for similarity-based virtual screening. These techniques were used to search the MDDR and WOMBAT databases. Binary fingerprints work well, but it was hoped that use of fragment frequency information might produce even better results. It is assumed that if two molecules have multiple occurrences of a fragment in common they are more similar than if they have just a single occurrence in common, and if two molecules share a very rare fragment, they are more similar than if they share a very common fragment. Experiments show that the former assumption is correct, but that there is much less evidence for the latter (Arif, S. M.; Holliday, J. D.; Willett, P. Analysis and use of fragment occurrence data in similarity-based virtual screening. J. Comput.-Aided Mol. Des. 2009, 23, 655-668; Arif, S. M.; Holliday, J. D.; Willett, P. Inverse frequency weighting of fragments for similarity-based virtual screening. J. Chem. Inf. Model. 2010, 50, 1340–1349).
Experiments in text retrieval show that documents retrieved by multiple search engines are more likely to be relevant to a query than if they are retrieved by a single search engine. To see if this effect also applies in cheminformatics, researchers at Sheffield have carried out extensive virtual screening experiments to investigate whether structures retrieved by multiple virtual screening methods are more likely to be active than if they were retrieved by a single method. Sets of 25 searches for a reference structure were carried out using five different similarity coefficients and five different fingerprints. As the number of searches increases from 1 to 25, there is a rapid decrease in the numbers of molecules retrieved in all of the searches, and a rapid increase in the percentage of those retrieved molecules that are active. This provides an empirical rationale for the use of data fusion, where multiple rankings of a database are combined to give a single, fused ranking. The Sheffield team has experimented with a whole range of different combination rules, some used previously and some novel. Their results show conclusively that one of the new rules, called CombRKP, is by far the most effective in virtual screening, this arising from the rule approximating molecular probabilities of activity (Chen et al. Combination rules for group fusion in similarity-based virtual screening. Molecular Informatics 2010, 29, 533-541).
The symposium presented an interesting mixture of history, philosophy, strategy and up-to-date research. Symposia in honor of people or journals can tend to lean towards nostalgia and self-congratulation, so it was a pleasure on this occasion to hear some recent results as well as the historical perspectives. The number of citations to the journal itself was impressive, even allowing for the fact that the speakers would be biased. JCIM is the foremost journal in cheminformatics (Willett. P. A bibliometric analysis of the literature of chemoinformatics. Aslib Proceedings, 2008, 60(1), 4-17), and I hope that it will continue in that role for the next 50 years.


text:
NewsBusiness
Why the ransom is only a fraction of the cost of a ransomware attack
Ransomware attacks cost firms up to $170bn in 2019. But the actual ransom demanded—usually in Bitcoin—was only one seventh of the total cost.
By Adriana Hamacher
Feb 12, 2020 Feb 12, 2020
Hackers and crypto are never too far apart. Image: Shutterstock
The expense of dealing with a ransomware attack is far in excess of what was previously thought, according to a report published on Tuesday by cybersecurity company Emsisoft.
Emsisoft's higher estimate for the total ransom payments demanded in 2019 was $25 billion. But this is only one seventh of the actual cost to the companies affected, which could be as much as $170 billion, according to its estimates. Most of these costs arise from downtime and are associated with dealing with the attack, rather than the ransom itself, according to the report.
Ransomware demands double in three months
Ransomware is malicious software that encrypts files, unlocking them only if the victim pays a fee—often in cryptocurrencies such as Bitcoin.
Attacks increased 41% in 2019, with 205,280 enterprises throughout the world affected, according to Emsisoft data submitted to the New York Times.
The price of the ransom demanded also doubled from $41,198 six months ago to $84,116 at the end of 2019, according to data from security firm Coveware. This increase is largely attributed to the increasing sophistication of new malware such as Ryuk and Sodinokibi.
Coveware also suggests that it takes an average of 16 days for enterprises affected by a ransomware attack to restore their networks. While average downtime is hard to calculate, Gartner has estimated that it costs the average firm a staggering $5,600 per minute.
So it's perhaps unsurprising to learn that 33% of companies pay the ransom demand, in order to mitigate their costs, according to the 2020 State of the Phish Report, published last month by another cybersecurity firm, Proofpoint.
Evolution of the ransomware ecosystem
Those responsible for the attacks have proved hard to identify. Bitcoin accounted for about 98% of ransomware payments, which are then converted to privacy coins such as Monero. Criminals operate from countries such as Iran, North Korea and Russia, which are beyond the reach of international law enforcement agencies.
According to Emsisoft, the country most often targeted is the US, followed by Italy and Germany.
In December, security experts described to Decrypt how ransomware has evolved into an industry, with the evolution of victim-facing software, customer-service centers to deal with payments, and specialist data recovery operations, who deal with hackers on behalf of victims.
"We have almost certainly significantly understated the cost of both ransom demands and downtime," Emsisoft concluded in its report.
In October, the startup unveiled a new decryption tool which it claims could stop 56% of attacks.
https://decrypt.co/19084/why-ransom-fraction-cost-ransomware-attack


Since i installed the newest patch for HU i am able to sign into battle .net and i can see all the available games that I can join but i cant join the games, and if by some stroke of luck i get into the game i get kicked out and told i lost my connection, i have 1 T3 dedicated line and when i do get kick my ping is between 30ms and 40ms. I can host a open battle .net game just fine. any suggestions would be appreciated.
If i understand, you're connecting to open battle net and trying to join a game there? Why don't you connect to Arimyth servers? If you run hu.reg, you should automatically see the server.
I can run open battle .net server just fine. I cant connect to the Arimyth servers and stay connected, I can sit in the chat room and talk but when i try to join a game it either tells me i cant connect or if I connect i drop after about 3 minutes. I dont have anti-virus blocking this program, or anytime of firewall messing with it. Is there a port i need to open on my router maybe? i know when i played Warcraft online i had to open 2 ports. i have a 20MB dsl connection so i know its not from a slow or weak connection.
I know diablo ii uses 6112-6119 those two ports and maybe 4000, but should already be open if you can host on open bnet.
I will setup those ports either way, i dont know if anyone can join my games when i host open bnet but i was able to create and not get kicked.
Imo, the fact that you can get into games sometimes, briefly if at all, suggests to me it's not a connection problem but a bad install. You did try a reinstall, right? Don't install to Program Files neither. That's all I got.
Did you run d2modsetup with admin rights?
Yes, I even went as far and re downloading all the files for installing HU. This is why i ended up leaving HU in the past because it would only connect 5% of the time at best. I have also tried installing this in several different OS's. Windows 7 32 bit home prem, 7 Ultimate, and even Windows xp wouldnt connect i kept getting handler messages.
What about the D2 and LoD files?
There should be a hu.reg file included in the download. Double click on it to add the proper registry entries for the realms servers. hope that helps.
I tried running the HU.reg and it didnt make a difference, I can see the Arimyth sever and log in to battle. I am unable to join/create games. I can host a open bnet game just fine but i dont know if I anyone can join it. Its not a bad install because ive tried reinstalling several times and even formatting the computer to get a fresh install on the OS. I know its not my internet because i tried it on T3 at work and my 15MB dsl at home.
If it's still doesn't work, i got no ideas left.
Do you use hi res 1.3CBeta or low res? What files are you downloading anyway. I've seen guys joining and insta "time out" but none of them had 1.3C/ran d2modsetup.
Its not a bad install because ive tried reinstalling several times and even formatting the computer to get a fresh install on the OS. I know its not my internet because i tried it on T3 at work and my 15MB dsl at home.
Do the logs in your HUdir mention anything useful?
I still have had no luck connecting to Bnet. I have installed the Diablo 2 LOD game into C:\Diablo II, I did full install. I then downloaded the LOD Patch 110, Hell unleashed 1.3b Core.rar, and the HU 1.3B High Res.rar. I installed the files in that order then ran my d2modsetup.bat.
Am i missing downloading something? or settings getting changed? also the mod files are in with my regular d2 lod files.
would be good if you would have the right patch, we are now on 1.3c.
Go to that link download the patch, re-run the d2modsetup.bat, and run with -direct -txt.


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text:
Latest on DanceTabs
DanceTabs Contributors
A sharp-eyed look at Dance & Ballet Across the World – from 2012 to Jan 2022
Flickr Galleries
Some News Items
Only Selective News Here – much more on Twitter
DanceTabs News
DanceTabs is now in Archive – Update and Appreciation
New York City Ballet – Mozartiana, Rubies, La Valse – New York
Royal Ballet – Romeo and Juliet (O'Sullivan and Sambé) – London
Barely Methodical Troupe @ London International Mime Festival – KIN – London
The Forsythe Company – N.N.N.N., Study #3 – London
Jann Parry
Asutake Shimaji and Yoko Ando in Forsythe's Study #3.
© Dominik Mentzos. (Click image for larger version)
The Forsythe Company
N.N.N.N., Study #3
London, Sadler's Wells
www.theforsythecompany.com
www.sadlerswells.com
What Merce Cunningham devised as an Event, William Forsythe calls a Study. In both cases, the choreographer has combined selections from his back catalogue to make a 'new' work, stripped of all previous associations: no sets or costumes, random props, arbitrary musical accompaniment to be ignored by the performers. Cognoscenti of the choreographer's oeuvre might be able to identify extracts; those not in the know make of each performance what they will.
For his company's latest Sadler's Wells season, Forsythe preceded Study #3 from 2012 with a quartet for male dancers from 2004. Its title, N.N.N.N, presumably means n for anybody, quadrupled. According to the programme note, the men represent 'a mind in four parts, writing out a text of the voice of the body'. What this means in practice is an ever-more-complex interplay of 16 limbs as the men, Amancio Gonzalez, Cyril Baldy, Fabrice Mazliah and Ander Zabala, link up, split apart and recombine.
The piece starts and ends with a dancer alone on a bare stage, treating his arm as an unfamiliar appendage. Gonzalez clasps his wrist, puts it to his forehead and wrestles with his elbow before being joined by the others, investigating everywhere arms can go. Their manoeuvres are punctuated by slaps, grunts and gasps providing a sound track. N.N.N.N. was originally accompanied by a Thom Willems score – but not at the Wells. Just mobile phones going off at the start. When the men pair up, their tussles resemble Russell Maliphant's duets for Michael Nunn and William Trevitt, on speed.
Though the men behave like college jocks, regular guys, they are obviously versatile dancers: their combinations are tightly choreographed, their playfights rhythmical, their timings precise. They're elegant even when they're clowning. Do we learn about them as individuals after 20 minutes in their company? Not really, which may be the reason for the anonymous title. They serve as cogs in a contrapuntal mechanism, while remaining vulnerable, everyman beings.
The Forsythe Company in Study #3.
Does Study #3 reveal how Forsythe's choreography has evolved over 30 years, first with Ballett Frankfurt (1984-2004) then with his own, smaller company, from 2005 on? Not really, since he excludes his ballet-based works – with the possible exception of Quintett (1993), bits of which I think I recognised. Since it has always been danced to a memorable Gavin Bryar's score, I can't be sure I could 'recontextualize' it in another setting, as the programme note advises. The 27 extracts were danced by 17 company members in (mostly) brightly coloured tops and dark tracksuit bottoms. A rack of clothes on one side of the stage went unused. Electric cables littered the floor, connected to microphones on stands and a loudspeaker in a plastic bowl.
The collage of choreography was linked by largely incomprehensible spoken contributions from company members, some concealed by bizarre headgear. Maybe the message is to make us pay attention to the voice of the bodies, not the speakers. Thom Willems is credited with the musical score. Movement sequences range from very swift to very slow, from intimate couplings to duets and trios where the participants ignore each other. A man in black sits on a chair, screeching repeatedly and flinging his arms wide, watched dispassionately by his fellows. Interlocked pairs like Japanes netsuke take ages to disentangle their limbs. A woman in a burgundy leather jacket (Ildikó Tóth) seems to turn herself as well as her clothing inside out. The choreography frequently seems counter-intuitive, moving backwards instead of forwards, disconnecting one part of the body from another, revelling in dis-co-ordination. Ingenious and disconcerting, it's as unenjoyable to watch as listening to an ill-tuned radio.
The most entertaining section is a kind of bird mating ritual to (live) tweets and squawks from the microphones. Eloquent and unpredictable, it's Forsythe at his most intriguing. But then Dana Caspersen launches into a monologue mourning The Loss of Small Detail and sets off into an exasperating parody of classical ballet. After 55 minutes, that's more than enough.
TagsAmancio Gonzalez Ander Zabala Ballett Frankfurt Cyril Baldy Dana Caspersen Fabrice Mazliah Gavin Bryar Ildiko Toth London Merce Cunningham Michael Nunn N.N.N.N. Quintett Russell Maliphant Sadler's Wells Study #3 THe Forsythe Company The Loss of Small Detail Thom Willems William Forsythe William Trevitt
Thick & Tight @ London International Mime Festival – SHORT & SWEET – London
New York City Ballet – Partita (Peck premiere), Summerspace, DGV: Danse à Grande Vitesse – New York
Akeim Toussaint Buck – Sadler's Wells Wild Card series: Radical Visions – London
English National Ballet – Raymonda by Tamara Rojo (premiere) – London
A long-established dance writer, Jann Parry was dance critic for The Observer from 1983 to 2004 and wrote the award-winning biography of choreographer Kenneth MacMillan: 'Different Drummer', Faber and Faber, 2009. She has written for publications including The Spectator, The Listener, About the House (Royal Opera House magazine), Dance Now, Dance Magazine (USA), Stage Bill (USA) and Dancing Times. As a writer/producer she worked for the BBC World Service from 1970 to 1989, covering current affairs and the arts. As well as producing radio programmes she has contributed to television and radio documentaries about dance and dancers.
Claudia Bauer | Foteini Christofilopoulou | Gay Morris | Graham Watts | Heather Desaulniers | Jann Parry | Josephine Leask | Karen Greenspan | Lynette Halewood | Marina Harss | Oksana Khadarina | Siobhan Murphy | Susanna Sloat | Valerie Lawson | Bruce Marriott (Ed)
The above list is composed of those whose work we feature regularly and have generally contributed in the last few months.
>> Complete list of DanceTabs Contributors and more info.
DanceTabs Tweets
Bill T. Jones and SITI Company – A Rite, /Time:Study 1 – San Francisco Brian Brooks / Moving Company – Flight Study, Quiet Music, Closing Distance – Jacob's Pillow Jonah Bokaer & Daniel Arsham – Study for Occupant as part of #recollections exhibition – London The Forsythe Company – Sider – New York William Forsythe – A Quiet Evening of Dance – London
Akram Khan (119) Alexei Ratmansky (231) American Ballet Theatre (296) Bach (116) Balanchine (134) Birmingham Royal Ballet (183) Bolshoi Ballet (186) Christopher Wheeldon (248) Coliseum (185) COVID-19 (115) David H. Koch Theater (182) Don Quixote (155) English National Ballet (320) Frederick Ashton (286) George Balanchine (294) Giselle (245) Jerome Robbins (166) Kenneth MacMillan (275) London (1783) Marianela Nunez (114) Mariinsky Ballet (151) Natalia Osipova (141) New York (596) New York City Ballet (357) Paris Opera Ballet (136) Petipa (144) Pina Bausch (123) Rambert (121) Romeo and Juliet (223) Royal Opera House (486) Rudolf Nureyev (115) Sadler's Wells (696) San Francisco (195) San Francisco Ballet (193) Scottish Ballet (128) Swan Lake (300) Tamara Rojo (132) Tchaikovsky (196) The Nutcracker (146) The Place (192) The Royal Ballet (676) The Sleeping Beauty (140) Vadim Muntagirov (116) Wayne McGregor (201) William Forsythe (137)
Bruce Marriott
Marina Harss
Siobhan Murphy
Scottish Ballet – The Nutcracker – Inverness
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text:
Community Challenges Justice Department Investigation of Houston Police Department
By Kofi Taharka
National Chairman – National Black United Front
Houston, Texas---The Black Justice Tuesday Coalition (BJTC) made a public response to the recent report that the United States Justice Department is investigating several cases of police use of excessive force by the Houston Police Department.
Anthony Childress, whose case is under investigation, expressed doubts about the outcome. "I have little faith in this system to produce justice for me or the other cases". Childress whose beating by police produced the loss of six teeth and a fractured jaw became emotional when speaking about his experience. "It has been very hard to live with the physical and emotional scars from my beating".
Krystal Muhammad Chairwoman of the Houston Chapter of The New Black Panther Party (NBPP) was flanked by representatives from the National Black United Front (NBUF), S.H.A.P.E. Community Center Council of Elders, Millions More Movement, Anti-Death Penalty Movement, Operation Outreach OG1 and members of the community.
"For the Department of Justice to finally investigate these cases is long overdue. There are thousands of cases of deadly and excessive force by the Houston "Pig" Police Department that also need to be investigated as well. There is a culture of racism and classism that is at the core of all of these cases" said Krystal Muhammad.
Ali Muhammad of NBUF reinforced the nearly 100 straight week protest calling for transparency in the way complaints are investigated.
The BJTC says an Independent Civilian Review Board with subpoena power, prosecutorial power and proper funding is a tool that can help curve the unchecked power of the police. The Coalition also calls for changes in regulations such as requiring all Houston police to live in the City of Houston, proper psychological testing of police and general decentralization of power and authority in HPD. Participants called for clarity about the announced investigations "When will they start? When will they end? What role will the public play in the final outcome?"
The diverse group assembled included Cindy Payton the lady who turned the now infamous tape of Chad Holley being beaten by HPD officers over to community activist Quannel X. The public release of this tape has unleashed a swarm of protest, community meetings, civil disobedience and calls for justice over the past two years.
The BJTC has been crystal clear that there actions over the past two years have been directed towards structural change towards a system that represents decades of injustice.
Activist Deric Muhammad who worked with Annica Lewis and Sebanstian Prevot challenged the Justice Department to prove the community skepticism wrong by coming back with meaningful charges against Police who use excessive force. The brutality case of Lewis and Prevot is also under review by the Justice Department. The BJTC raised its voice loudly in protest when Brian Claunch a double amputee with a history of mental illness was killed by HPD earlier this year. His death is also under investigation by the Justice Department.
The BJTC which protest against police brutality every Tuesday at 12 noon in front of the Harris County Court House 1201 Franklin was received well by the crowd that gathered around the press conference.


FULL MEMBERSHIP: Full membership is $300 per year and may be paid in one payment, or in quarterly or monthly installments, but you must tell us which type you will do. It entitles a member to exhibit in SICC member exhibits; to sell in the Artisan Market at no additional cost; to participate in SICC Gallery Craft Fairs with no table cost; to have input regarding member activities, and to vote in the election of officers. Sitting time is a requirement of full membership whether participating in an exhibit, or selling in the Artisan Market. A $20 hanging fee and 20 percent commission applies for member exhibits, and a 20 percent commission will apply to Artisan Market sales.
ARTISAN MARKET MEMBERSHIP: An Artisan Market Only membership is $150 per year, and may be paid in one payment, or in quarterly or monthly installments, but you must tell us which type you will do. It entitles a member to display space at the back of the gallery (currently two or three shelves, or two shelves and use of the art bins). It also entitles a member to participation in SICC Gallery Craft Fairs ($20 per 6' to 8' space). There is a 20 percent commission to SICC on sales made from the Artisan Market, except on sales made during a craft fair, if the Artisan Market member is participating in the craft fair. Sitting time, as needed to ensure adequate coverage at SICC is a requirement of Artisan Market membership.
CRAFT FAIR MEMBERSHIP: A Craft Fair Only membership is $60 per year, and may be paid in one payment, or in quarterly or monthly installments, but you must tell us which type you will do. Members also must pay $20 per 6' to 8' space for any craft fair held in the SICC gallery, Art on the Terrace. Craft Fair spaces may be sold to non-members at double the member rate if there is room, or if members fail to respond in a timely manner. There is no current sitting time requirement for this kind of membership.
SUPPORTING/ASSOCIATE MEMBERSHIP: The Supporting/Associate membership is $60 per year, and may be paid in one payment, or in quarterly or monthly installments, but you must tell us which type you will do. Supporting/Associate members can participate in one (1) SICC member exhibit show of their choosing per year. The exhibit fee will be $30, with a 30 percent commission. *There is no sitting requirement for this level of membership unless the member is participating in the one show of their choosing. There will be a sitting requirement for the duration of the chosen show. We always welcome voluntary sitting from our Supporting/Associate members.
The fee for a Craft or an Art space in our Annual Art by the Ferry Festival, or other SICC larger-scale or collaborative event is subject to a higher rate.
Occasionally, we will invite non-members to show their art if there is space in an member exhibit. For non-members, the hanging fee will be $60, plus 30 percent commission and required sitting. We need one member sitting with a non-member.
ONLY FULL MEMBERS CAN VOTE, BUT ALL MEMBERS CAN ATTEND MEETINGS AND EXPRESS THEIR OPINIONS.
ALL MEMBERS ARE REQUIRED TO GIVE THREE (3) VOLUNTEER HOURS TO OUR ANNUAL ART BY THE FERRY FESTIVAL.


text:
import {action, observable} from "mobx";
import React from "react";

import Effect from "app/models/Effect";
import Piece from "app/models/Piece";

import Matrix from "app/components/Matrix/Matrix";

import "./SparePieceEffect.scss";

export default class SparePieceEffect extends Effect {
    @observable piece: ?Piece;

    @action setPiece(piece: Piece) {
        this.piece = piece;
    }

    render(blockSize: number) {
        const size = `${blockSize * 4 * .5}px`;
        const style = {width: size, height: size};

        return (
            <div className="SparePieceEffect" style={style}>
                <header className="SparePieceEffect-header">
                    Spare
                </header>

                {!this.piece ? null :
                    <Matrix matrix={this.piece} blockSize={blockSize * .35}/>
                }
            </div>
        )
    }
}

redpajama_set_name: RedPajamaGithub


text:
'This is an exciting opportunity': Predators, F&M Bank to share MPEC naming rights
One of the most iconic sports brands in middle Tennessee will be joined by one of Clarksville's most iconic businesses, in naming the new Montgomery County downtown events center.
Sabertooth Sports & Entertainment, LLC and Clarksville-based F&M Bank have executed a multi-year naming rights agreement for the multipurpose events center, officials announced Tuesday afternoon at the bank's main office on Franklin Street.
A specific name and logo for the venue will be announced at a later date. Sabertooth Sports & Entertainment, LLC is owned and operated by Predators Holdings, LLC — the Nashville Predators.
The announcement comes one week after the Predators unveiled the formation of SS&E, an operations and sales service venture that will manage the 250,000-square-foot facility.
The venue's primary tenant will be Austin Peay State University sports teams — men's and women's basketball.
"No matter what the last name of the center will be called – forum, stadium, coliseum, hippodrome or arena – it won't matter, because the first portion being F&M Bank all but guarantees our success," Nashville Predators President and CEO Sean Henry said in a statement.
Henry, among others Tuesday, was quick to credit Montgomery County Mayor Jim Durrett for visioning the events center, and F&M Bank led by Sammy Stuard, for rounding out its strategy for success.
And, he said Clarksville Mayor Joe Pitts and Austin Peay State University Athletics Director Gerald Harrison "jumped on board with their own visions for what the event center could do for their city and school, respectively.
"The one thing we were missing was a dynamic, community-minded business leader to fully bring that project to life, and you can't ask for a more community-centric individual than F&M Bank President and CEO Sammy Stuard. The core values at F&M Bank align so well with what we will achieve with this event center," Henry said.
Last November, ground broke on the facility, and it continues at First Street and College Street. The venue is scheduled to open during the 2022-23 season under SS&E management.
"This is an exciting opportunity to partner with Montgomery County, Sabertooth Sports & Entertainment, LLC and the Nashville Predators on such a monumental investment in historic downtown Clarksville," Stuard said.
Tuesday's announcement was emceed by radio's Voice of the Predators Pete Weber, and showcased all of the top brass in the deal for naming rights.
Stuard told the afternoon gathering in the Franklin Room on the bank headquarters fifth floor, "F&M Bank has been in this community for over 30 years and has been able to watch this community grow throughout that time.
"When the arena was first announced, we said, 'it's got to have the F&M Bank name at the top of it," Stuard said.
"The quality of life for people who live in this community will benefit from this facility. Let's get some great Preds spirit down here, and Let's go Peay," he said.
Durrett, in remarks, first thanked the county commission for voting in favor of the $130.7 million downtown arena facility through all of its phases.
"If you look back over the history of this project, they (county commission) heard and saw the vision," Durrett said.
"I've been here a long, long time. (F&M) Bank has been here a long, long time ... and I remember when the bank took a big leap of faith and built this (downtown headquarters) building that we're standing in today.
"This is an organization that has consistently supported this community, so I could not be happier to have F&M Bank's name on top of our events center," Durrett said.
Durrett has announced he won't seek re-election for a third term as county mayor next year, but told The Leaf-Chronicle when asked Tuesday, "I promise you I'll be back for the (events center) ribbon-cutting."
Pitts, in turn, praised his co-leader in local government, Durrett, saying, "If it weren't for Mayor Durrett's vision, there would be no building to name. He also thanked F&M Bank "for hiring good people and supporting the community."
For Harrison, Tuesday's announcement was more like a pep rally. "How awesome is this," he said.
"To have an opportunity to move into the best venue for college basketball in the nation is amazing, and to have F&M Bank's name on it ... we're not just going to be great just in the Ohio Valley Conference, but also across the country," Harrison said.
With Tuesday's announcement, Durrett said Smashville (Predators) essentially meets Stacheville (APSU Govs), Clarksville and F&M'ville, adding, "it's all part of what makes Montgomery County a great place to live."
The venue's primary tenant will be Austin Peay, whose men's and women's basketball teams will call the facility home.
In addition to the facility's main, flexible event space – which will be able to host sporting events, concerts, banquets, conventions, trade shows and other events – the multi-level venue will feature a separate sheet of ice that will be used for youth and adult hockey leagues as well as figure skating.
The main arena bowl will also be able to add an ice surface, giving it the ability to host hockey tournaments and attract larger on-ice events or competitions much like the existing Ford Ice Centers in Antioch and Bellevue.
Using these ice sheets, the Predators will offer a variety of learn-to-skate programs at the facility, continuing their mission to expose and grow hockey to more Middle Tennessee residents. It also will contain luxury suites, premium seating, private hospitality space, party rooms and common areas that will have full access to the arena bowl.
The Austin Peay men's and women's basketball teams will move their coaches' offices and training facilities into the facility, which will also house their practice court. The soon-to-be-named venue will hold roughly 6,000 fans for concerts; 5,500 for basketball games; and 5,000 for hockey games.
Reach Jimmy Settle at jimmysettle@theleafchronicle.com or 931-245-0247. To support his work, sign up for a digital subscription to TheLeafChronicle.com.


Wine snobs, cover your ears. The history of wine in New Mexico predates even the French Revolution, and the state is home to the first vineyards in the United States. The state's wine culture combines the world's best varietals with local expertise on cultivation, leaving connoisseurs around the world thirsting for more. Unlike some other wine regions that depend on transplanted grapes, New Mexico's vines have been developed over centuries, with the grapes uniquely shaped by the landscape. Ready for a sip? At the Corrales Winery you can taste their Cabernet Sauvignon as you take in the views of the Sandia Mountains, while there are wine tours throughout the state and food and wine events throughout the year.


Last year, GOOD reported on the "pink tax," an unfair business practice that costs the average American woman $100,000 over a lifetime for shopping in the women's aisle at pharmacies and supermarkets. In the U.S., female-branded personal hygiene products cost 14 percent more than those marketed to men—even when they contain the same ingredients. Plus, women pay 56 percent more for haircuts and 92 more percent for dry cleaning. While women in the U.S. continue to be gouged for their gender, a major supermarket in the U.K. has just stepped up to help slash the tax on women.
Tesco's decision comes on the heels of a report in The Times that found U.K. "stores are charging women up to twice as much as men for practically identical products." This was backed up by a report in The Guardian that said U.K. "women were paying an average of 37 percent more for gender-targeted items, ranging from toys to beauty products." Hopefully, this move by one of the world's largest chains will inspire U.S. retailers to slash the pink tax on this side of the pond as well.


Blog Entries Tagged: Parkview Loop.
Found 9 blog entries tagged as "Parkview Loop.".
Thursday, September 29th, 2011 at 2:48pm.
On 10/19/2005, 166 Parkview Loop was publicly recorded as sold for $270,000. This is a condo in the neighborhood of Bulls Head, Staten Island, 10314. This residence was built with a living space of 1142 square feet on 392337 square feet of land in 0. It is located on block 1552, lot 1124.
Thursday, September 29th, 2011 at 2:47pm.
On 12/2/2005, 160 Parkview Loop was publicly recorded as sold for $285,000. This is a condo in the neighborhood of Bulls Head, Staten Island, 10314. This residence was built with a living space of 945 square feet on 392337 square feet of land in 0. It is located on block 1552, lot 1119.
Thursday, September 29th, 2011 at 2:46pm.
On 1/14/2005, 128 Parkview Loop was publicly recorded as sold for $262,000. This is a condo in the neighborhood of Bulls Head, Staten Island, 10314. This residence was built with a living space of 1142 square feet on 392337 square feet of land in 0. It is located on block 1552, lot 1087.
Thursday, September 29th, 2011 at 2:45pm.
On 4/5/2005, 90 Parkview Loop was publicly recorded as sold for $250,000. This is a condo in the neighborhood of Bulls Head, Staten Island, 10314. This residence was built with a living space of 1142 square feet on 392337 square feet of land in 0. It is located on block 1552, lot 1071.
Thursday, September 29th, 2011 at 2:44pm.
On 11/2/2005, 73 Parkview Loop was publicly recorded as transferred without consideration for money. This is a condo in the neighborhood of Bulls Head, Staten Island, 10314. This residence was built with a living space of 1142 square feet on 392337 square feet of land in 0. It is located on block 1552, lot 1097.
Thursday, September 29th, 2011 at 2:43pm.
On 9/12/2005, 63 Parkview Loop was publicly recorded as sold for $340,000. This is a condo in the neighborhood of Bulls Head, Staten Island, 10314. This residence was built with a living space of 1480 square feet on 392337 square feet of land in 1980. It is located on block 1552, lot 1032.
Thursday, September 29th, 2011 at 2:42pm.
On 2/10/2005, 53 Parkview Loop was publicly recorded as sold for $320,000. This is a condo in the neighborhood of Bulls Head, Staten Island, 10314. This residence was built with a living space of 1480 square feet on 392337 square feet of land in 1980. It is located on block 1552, lot 1036.
Thursday, September 29th, 2011 at 2:38pm.
On 6/22/2005, 25 Parkview Loop was publicly recorded as transferred without consideration for money. This is a condo in the neighborhood of Bulls Head, Staten Island, 10314. This residence was built with a living space of 1480 square feet on 392337 square feet of land in 1980. It is located on block 1552, lot 1037.
Thursday, September 29th, 2011 at 2:37pm.
On 9/9/2005, 11 Parkview Loop was publicly recorded as sold for $362,500. This is a condo in the neighborhood of Bulls Head, Staten Island, 10314. This residence was built with a living space of 1480 square feet on 392337 square feet of land in 1980. It is located on block 1552, lot 1043.


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Conference Focuses on African-American History
Read the full story by Steve Smith, published by Dartmouth Alumni News.
The history of African-American students at Dartmouth was talked about by Forrester "Woody" Lee '68 in his presentation "History of African Americans at Dartmouth College 1775–1950" during a "Blacks @ Dartmouth" conference held on campus from March 28 through March 30. In just 45 minutes, Lee altered the way some members of the Black Alumni of Dartmouth Association (BADA) and the Afro-American Society saw the early history of African-Americans at Dartmouth.
Ellis Rowe '74, president of BADA, was among the more than 70 people who attended the conference in March. (Photo by Eli Burakian '00)
A professor of medicine at Yale, Lee has been researching this topic in his free time for the past year. He's visited Rauner Special Collections Library and used Yale and Dartmouth online resources. Lee found that more than 130 African-American students—a number much higher than originally known to BADA—had studied at Dartmouth prior to 1950, beginning with the matriculation of Edward Mitchell, Class of 1828.
Prior to the Civil War, "Dartmouth was recognized in the African-American community as a place where a man of color could go to get educated," says Lee. "Some of these students were rejected by other institutions. It's a fascinating story and one we should be very proud of." Some of the early graduates of Dartmouth and of Dartmouth Medical School went on to be the first college-educated doctors and lawyers in Liberia, surgeons in the Civil War, a clergyman in Philadelphia, and a civic leader and active abolitionist in Boston.
In admitting Mitchell in 1824, Lee noted, Dartmouth was the forerunner among Ivy League schools, as the next college to admit an African-American student was Harvard in 1870.
Ellis Rowe '74, president of BADA, was among the more than 70 people who attended the conference. Rowe noted that many alumni were familiar with the history of black alumni at Dartmouth from about 1960 onward, but they were unaware of the depth and richness of their involvement in the College's history from virtually the founding date of the College in the 18th century.
"Woody showed us that Dartmouth was early in bringing black students to campus—earlier than many of the other Ivies, and earlier than we knew about," says Rowe. "In many ways we were building upon the history of what students and alumni have accomplished before us."
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Implementation and Innovation in the NSDL by William Arms
September 18, 2008 at 2:07 pm Brandon Muramatsu	2 comments
The Cornell demonstration project
Since the Cornell demonstration project, Site for Science [3], became the technical basis for the central NSDL system, it is interesting to compare what was envisioned in 2000 with what has developed since. Reading the Cornell proposal today, with the benefit of hindsight, I am impressed with how strong it was technically and how little emphasis it gave to other important areas.
Today's central system has many technical similarities with the Site for Science prototype, particularly in the central role of a metadata repository. The details have changed, e.g., a relational database has been replaced by a Fedora repository, but the proposal was explicit about the role of Dublin Core and the importance of compound digital objects. It had an interesting section that anticipates personal information services of the type now known as Web 2.0. The prototype was an early adopter of the OAI-PMH.
Elsewhere, the demonstration project was less strong. There was no recognition of the differences between K-12 and higher education. The focus was on building a virtual library that will be a resource for everybody interested in science. In the tradition of higher education, the goal was to make primary materials available, with no distinction between the library provision for students, teachers, and researchers. There was no understanding that this model of a library needed to be modified for K-12 education.
The organizational issues that frustrated the early years of the NSDL were mainly ignored in the proposal. There was little consideration of how to combine the various small projects into a coherent whole, but it was assumed that there would be a federation with the NSF providing firm direction via the Core Integration team. There was an optimistic assumption that many of the major partners would be external projects that were not funded by the NSF.
The 2000 solicitation had a few sentences on how the NSDL might continue when the original NSF funding expired and the Cornell proposal had a short section on this topic, but only in the context of the central system.
Entry filed under: NSDL Core Integration. Tags: National Science Digital Library, NSDL, NSDL Reflections.
Welcome to NSDL Reflections!	Reflections on NSDL by Frank Wattenberg
1. Flora McMartin | March 18, 2009 at 4:24 pm
Bill writes that NSDL has been faced with two challenges: supporting education at all levels and mixing the missions of innovation and implementation. He adds that the "aim was to implement a digital library, but the funding program was more suitable for a broad program of research and development."
Given the broad and mixed mission, does NSDL need to focus its resources in particular areas to ensure longer term sustainability? What would those areas of focus be, and can digital library services be created that provide value to some set of users or funders?
2. » Innovation in Cyberlearning: NSDL Progress Report at NSF » NSDL Road Reports | April 24, 2009 at 1:59 pm
[…] explaining its 1996-1997 roots in NSF-funded planning studies (see NSDL Reflections Weblog, "Implementations and Innovation in the NSDL" by William Arms). Dr. Linda Slakey, NSF Division of Undergraduate Education Division Director […]


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Q: How to understand Lemma 4.4 in Hartshorne, Chapter 2? I have essentially the same question as in some question of Hartshorne book Lemma (II.4.4).
However, even with the answer in that question, I am still confused what does ''local homomorphism of $O_{x_0,Z}$ to $R$ is compatible with the inclusion $k(x_1) \subset K$'' mean, and why?
In particular, I noticed there were people asking why this local homomorphism is injective in the comment, therefore I wonder if anyone can explain this more clearly.

A: Step 1: If $A\to B$ is a morphism of schemes with $a\mapsto b$, then we have an induced local map on local rings $\mathcal{O}_{B,b}\to\mathcal{O}_{A,a}$. This should be familiar from the definition of a morphism of locally ringed spaces: if you need some jogging of your memory, it may be helpful to recall the affine case and use the universal property of localization.
Step 2: If $A$ is a scheme with $a_1,a_0$ points so that $a_1$ is a generalization of $a_0$, there is a natural map $\mathcal{O}_{A,a_0}\to \mathcal{O}_{A,a_1}$, and it's a localization. You can see this either by calculating on an open affine neighborhood of $a_0$, where it correpsonds to the fact that $R_\mathfrak{q}$ maps to $R_\mathfrak{p}$ by localizing for $\mathfrak{p}\subset\mathfrak{q}$ prime ideals, or from the definition of the stalks as inverse limits over open neighborhoods: any open neighborhood of $a_0$ contains $a_1$ and thus there's a natural map induced on the limits.
Step 3: If $A\to B$ is any map of schemes with $a_0\mapsto b_0$, $a_1\mapsto b_1$, and $b_0\in \overline{\{b_1\}}$, then we also have that $a_0\in\overline{\{a_1\}}$ and the following diagram commutes:
$$\require{AMScd}
\begin{CD}
\mathcal{O}_{B,b_0} @>{}>> \mathcal{O}_{A,a_0}\\
@V{}VV @VV{}V \\
\mathcal{O}_{B,b_1} @>{}>> \mathcal{O}_{A,a_1}
\end{CD}$$
This is a combination of steps 1 and 2. If you want to see it in a more hands-on way, you can let $A$ and $B$ be affine (by selecting an open affine neighborhood of $b_0$ [this contains $b_1$ since open subsets are stable under generalization] and then an open affine neighborhood of $a_0$   [also containing $a_1$ for the same reason] contained in it's preimage) and use the universal property of localization a couple times.

Now to apply the above to our situation. In our case, $A=\operatorname{Spec} R$, $a_0$ is the maximal ideal $\mathfrak{m}\subset R$, $a_1=(0)\subset R$, $B=X$, and $b_0=x_0$, $b_1=x_1$. Rewriting our commutative  diagram, we have
$$\require{AMScd}
\begin{CD}
\mathcal{O}_{X,x_0} @>{}>> R\\
@V{}VV @VV{}V \\
\mathcal{O}_{X,x_1} @>{}>> K
\end{CD}$$
where the horizontal maps are local maps of local rings. Now we use a couple of universal properties: first, letting $I=\ker \mathcal{O}_{X,x_0}\to R$, the map $\mathcal{O}_{X,x_0}\to R$ factors through $\mathcal{O}_{X,x_0}/I$. As $I$ is the kernel of a morphism to a domain, it's prime, and so the map $\mathcal{O}_{X,x_1}\to K$ factors through $\mathcal{O}_{X,x_1}/I_I$. We may further note that $I_I$ is the maximal ideal of $\mathcal{O}_{X,x_1}$ as our map is a local map of local rings where the target is a field. This corresponds to restricting to $Z$ with the reduced induced structure, since $I$ is prime. Replacing $\mathcal{O}_{X,x_0}/I$ and $\mathcal{O}_{X,x_1}/I$ with $\mathcal{O}_{Z,x_0}$ and $\mathcal{O}_{Z,x_1}=k(x_1)$ we have the following commutative diagram, where the horizontal arrows are still local ring maps:
$$\require{AMScd}
\begin{CD}
\mathcal{O}_{Z,x_0} @>{}>> R\\
@V{}VV @VV{}V \\
k(x_1) @>{}>> K
\end{CD}$$
This commutative diagram is what Hartshorne means by a local homomorphism of $\mathcal{O}_{Z,x_0} \to R$ compatible with the inclusion $k(x_1)\to K$.

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