A lot of companies have been considering business expansion into Canada, with many more hoping to take the leap in the new year. Canada is a large, diverse country with a great deal of opportunity and a lot of untapped potential in terms of the market. Business expansion just makes sense. That being said, there is always some sort of barrier and, regardless of country, it tends to be administrative in nature.
You have new laws to consider, a new environment and marketplace to familiarize yourself with, and a healthy amount of bureaucracy to wade through before you can begin. The process doesn't have to be completely painful, however—there are ways to make it simpler that can benefit everyone.
Any business expansion into Canada, of course, needs to start with a plan. But that's not the only thing. You need to consider the administrative process involved in effectively starting a "new" business. This means registering with the Canadian Revenue Agency (the IRS of Canada) and obtaining a business number. Without a business number, you're unable to operate on any level within Canada. That means no hiring, no sales, no offices, and no ads. It's a very critical step.
Once you have your business number, you'll have tax accounts to deal with. This means you'll want to do some pretty intense research to ensure you can meet Canadian tax codes, as well as comply with local, provincial, and countrywide labour, employment, and human rights laws. Health and safety laws also need to be taken into account. Your business expansion into Canada means learning and following all Canadian laws.
On average, registration takes a few weeks or months, but can often end up taking longer than expected, depending on the complexity of your filing, the size of your company, as well as several other factors. You'll want to plan ahead for some extra time so you don't miss any important deadlines, or jump the gun on any important decisions. If this all sounds like a lot of trouble, there's another way to simplify your business expansion into Canada: a professional employer organization.
A professional employer organization (or, an employer of record as they're known) is by far the easiest path to simplification. Given all the work involved in business expansion, it's no wonder that so many businesses decide against it—even if it hampers international growth and opportunity. That said, PEOs and EORs are becoming increasingly popular for their services and a favourite of those who want to expand. Consulting a PEO means you can skip administrative woes and get started in Canada faster.
A PEO already has a Canadian presence. That means a business number, tax registration, appropriate banking and financial infrastructure, and everything else required. When you partner with one, they're hiring employees on your behalf—they pay them, they handle human resources, they even file your taxes for you—and all of that means you can skip the whole registration process and get started sooner. Naturally, you still retain control over operations as well as employees, which means all the oversight you require with less work. PEOs are not just payroll experts, but they also specialize in human resources and legal compliance, which rolls several departments into one. If you're a business that partners with a PEO, you'll save a great deal of money, resources, and time.
Consider how simple your business expansion into Canada could be if you could set your schedule ahead by several months. Talk to a PEO and find out just how simple it can be.


THE streets of Newcastle West will once again witness the solemn enactment of the Way of the Cross this Good Friday.
The pageant, which attracts hundreds of spectators each Easter, will begin at 2.30pm and the band of Transition Year students from Desmond College, Newcastle West, who are the backbone of the event, are more than ready to take their places.
They are, they admitted, looking forward to it.
It is now 10 years since the first Way of the Cross made its way through the streets of Newcastle West and the event has drawn visitors to town ever since. "The first year, people were astonished," Emma continued. And both she and Orla are agreed that it is a solemn occasion. "People have come from all over, some even from Canada. That is why we take it seriously because they take it seriously," added Orla.
Rehearsing for this undertaking does however take a bit of preparation. "You need to know what you are doing," Emma pointed out. For the male students, playing the role of Roman soldiers is not an easy task. The shields are large and quite heavy, and the swords too are hefty enough. In addition, the exceptionally good metal helmets are also weighty.
But they are looking forward to the job with interest, having volunteered for the event. "We have done the main route and what our positions are in the church, the commands and so on," Liam Dowling explained. He put his name in for the event because he wanted to get involved, as did fellow pupil and centurion, John Hunt. "I was very interested in the whole thing," he explained.
The students will be joined by members of Legion Ireland, a Roman re-enactment society from Cork and re-enactor Brian Smith will play the role of Christ.
Art teacher at Desmond College, Sean Shiels, who is a member of Legion Ireland, is co-ordinating the event and other teachers from the school will act as stewards.
The Way of the Cross gets underway this Friday, at 2.30pm. The route begins at Calvary Cemetery and moves down Church Street, through the Square and along Bridge Street to reach the Church of the Immaculate Conception by 3pm. The cruxifixion will be partially enacted and the cross raised as part of the ceremony.


text:
This website uses cookies. By continuing to use this website, you consent to our use of these cookies. You can find out more about how we use cookies and how to manage them by reading our Cookie Policy.
Pleasant breath
for Longer
Why use CB12?
Actively neutralises bad breath
Patented 12-hour formula
Strengthens enamel with daily use
Bad breath on a date
Dry mouth and bad breath
Children, puberty and bad breath
Low carb diets and bad breath
Menopause and bad breath
Pregnancy and bad breath
How to brush your teeth
Stained and discoloured teeth
CB12 Products
CB12 mouthwash
CB12 Boost
CB12 Spray
CB12 Reviews
The Confidence Guide
Palliative care dentistry and bad breath
CB12 BLOG
Fresh Breath for Healthy Living
Monday, October 15th, 2018 – Healthly Living
Naturally, young people compare their appearance with models, actors and celebrities depicted in advertising and the media. Youngsters also have a tendency to ignore other abilities and focus on appearance as evidence of worthiness.
However, there is still much to commend about this generation's attitudes towards fitness and wellbeing as they lay down the foundations for a healthy life.
In general, the younger generation has a healthy disposition and research conducted over the last decade reveals that an increasing proportion of youngsters eat fruit and vegetables, are physically active on a daily basis, rate their health as excellent, practice safe sex, and live free of tobacco and cannabis. There is also a decline in those that drink alcohol weekly and gym use has increased threefold in a generation. The consequences are that young adults are now more inclined to take regular exercise than people did 30 years ago and 48% of 16-24 year olds use a fitness app on a regular basis. Special diets that focus on organic, lactose and dairy-free foods have trebled in popularity over a generation, but conversely, young adults are placing much less emphasis on their oral health.
According to statistics, the number of people that visited an NHS dentist in England has fallen since 2013. Furthermore, the highest prevalence of decay on the crowns of the teeth was found in adults aged 25 to 34. This would indicate that although young adults seem to be better informed and enthusiastic about their general health and fitness some are neglecting to look after their teeth.
The condition of the teeth significantly affects a person's appearance and cracked, missing, stained or unhygienic teeth look unhealthy and unattractive. Along with this, untreated dental problems, a build up of plaque and periodontal disease are common causes of oral malodour, which can lead to a lack of confidence and social withdrawal. As we know, the health of the mouth impacts significantly to the general wellbeing of the body and effective oral hygiene is required to preserve it. When speaking to young patients, dental professionals need to reinforce the message and encourage them to take their oral health just as seriously as every other aspect of their fitness.
Along with effective tooth brushing and interdental cleaning, it is wise to implement a mouth rinse into your daily routine to keep breath smelling fresh. With the hectic lifestyle that many young people lead, CB12 mouthwash can be used as a convenient daily oral deodorant to prevent bad breath. Just one shot begins working instantly and its unique, patented formula adheres to the tissues of the oral cavity to eliminate unpleasant breath for up to 12 hours. As well as the rinse, CB12 boost is a sugar free chewing gum that can be used to freshen and invigorate the breath after meals and throughout the day. CB12 products have been developed by dentists and contain specific ingredients to reduce plaque, strengthen teeth and prevent cavities so you can empower young patients to look after their oral health with confidence.
1) Trends in young people's health and social determinants. The European Journal of Public Health Volume 25, Issue suppl 2, 1 April 2015. eurpub.oxfordjournals.org/content/25/suppl_2
2) The health and care of young people. June 2015 Health and Social Care information Centre.
www.hscic.gov.uk/catalogue/PUB17772/Focus-on-h-c-young-people-main-June-2015.pdf
3) The Good Life report commissioned by Holland and Barrett. 2014. Available at www.telegraph.co.uk/sponsored/health/good-life/
4) NHS Dental Statistics for England 2014/15. 20th August 2015. Health and Social Care Information Centre. www.hscic.gov.uk/catalogue/PUB18129/nhs-dent-stat-eng-14-15-rep.pdf
5) Executive Summary: Adult Dental Health Survey 2009. 24th March 2011. Health and Social Care Information Centre. www.hscic.gov.uk/catalogue/PUB01086/adul-dent-heal-surv-summ-them-exec-2009-rep2.pdf
Healthly Living
CB12 in the media
Select Month October 2018 June 2017 May 2017 March 2016 February 2016 September 2015 June 2015 May 2015 April 2015 December 2014 November 2014 October 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014
Get Well Faster
WHY GO TO THE DENTIST?
Contrary to popular belief, the role of dental professionals is not just to fix your teeth. Practitioners are highly trained to look after your teeth and gums but also to recognise any potential problems and hopefully prevent them before they affect your wellbeing.
You are leaving cb12
You are now leaving this Mylan affiliate site. Mylan is not responsible for the content of the site you are about to visit.
CB12® is a registered trademark of Mylan N.V and its affiliates.
Mylan N.V.
Building 4 Trident Place
Mosquito Way
AL10 9UL.
Email: enquiry@mylan.co.uk
© Copyright 2019 Mylan N.V. All rights reserved.
Please also visit our other Mylan pages:
mylan.co.uk
difflam.co.uk
dermatix.co.uk
endwarts.co.uk

redpajama_set_name: RedPajamaCommonCrawl


Are you searching for the Uttarakhand Helpline number for Flood / Rain rescue. Then you can get them all on this page. We are sharing the contact numbers which can be used to contact your stucked relatives, family members or friends etc.
With effect of Pre-Monsoon rains and early Monsoon rains Uttarakhand (Uttaranchal) is facing flood situation. So many people are dead and other are finding the way to come out from that deadly situation. After starting the rescue operations Govt. has also started the helpline numbers which will help the people to get information about situation.
These contact numbers are of Uttarakhand based control room for the rescue operations which are running over there. Govt. is trying to make the situation under control. If you want to contribute or donate for the people over there. For that also you can contact on this number.


text:
Tag Archives: Phil Spencer
Xbox to Appear at The PC Gaming Show !
Xbox One at the PC Gaming Show ? hmmmmmmm
Microsoft Joins AMD as Sponsor and Participant for PC Gamer's Live Event at the Belasco Theater
LOS ANGELES – June 3, 2015 – PC Gamer today announced that Microsoft has joined the upcoming "AMD Presents The PC Gaming Show Powered by PC Gamer" event as both a sponsor and participant. Taking place in Los Angeles on Tuesday, June 16, 2015 at the Belasco Theater, the show will feature appearances and announcements from some of the biggest names in the PC gaming industry. Head of Xbox, Phil Spencer and several game developers will share the latest details about gaming on Windows 10 as well as showcase several upcoming games.
"For us, the PC Gaming Show is the ideal place to speak directly to PC gamers, and it's a great time to talk about Windows 10 – the best operating system we've ever created for gamers on PCs," said Phil Spencer, head of Xbox at Microsoft. "With Windows 10, we're bringing the best of Xbox with the best of Windows gaming, including Xbox Live and the new Xbox app, Game DVR for nearly every game, and DirectX 12 for better gaming graphics and performance."
"Windows is a vital element of the PC gaming experience for so many of us, and I'm excited to see what Microsoft has in store," said Tim Clark, Global Editor-in-Chief, PC Gamer. "The PC Gaming Show is a celebration of every aspect of the platform, so I'm delighted Xbox has decided to play such a key part in it."
Presented by AMD, organized by PC Gamer, and streamed live in partnership with Twitch, the show will bring the PC gaming community together under one roof for announcements and presentations from both major companies and rising independent developers. Hosted by Sean 'Day[9]' Plott, participants of the show include Dean Hall (DayZ), Blizzard, Bohemia Interactive, Tripwire Interactive, Fullbright, Cliff Bleszinski (Boss Key Productions), Devolver Digital, Nexon, Creative Assembly, Square Enix, CCP Games, Paradox Interactive, and many more.
For more information and to register for press access, please visit: http://www.PCGamingShow.com and follow #pcgamingshow.
By Vampero • Posted in PC Software, XBOX ONE	• Tagged Gaming Show, Microsoft, PC, PC Gamer, Phil Spencer, Xbox One
Xbox Empire – New Japanese Games Announced for XBO !
Lionhead Working on New Ip Unrelated to Fable – Rare has New Games in Developement – Kami
RARE HAS MICROSOFT'S SUPPORT AND NEW GAMES IN DEVELOPMENT
BY LUKE KARMALIMicrosoft has promised it is continuing to support Rare following its decision to stop bundling Kinect with Xbox One.
Microsoft Studios Europe chief Phil Harrison told Eurogamer that despite the recent round of layoffs to hit the former Banjo-Kazooie developer, Microsoft has no plans to abandon the studio.
"I'm very happy to go on record to alleviate any of those concerns you might have," he said. "We are very fortunate in having Rare and Lionhead in the UK as crown jewels of Microsoft Studios.
"Rare is working on a couple of things at the moment, which we will announce at the right time. But I'm really excited by the things they're doing and I believe you will be as well when you hear about them.
"Rare is an incredible talent and they have some very very ambitious plans for the future and we're supporting them in every way we can."
Last we heard, Rare was apparently re-evaluating what projects to pursue following the decision to stop bundling Kinect with new Xbox One consoles, seeing as most of the studio's recent work was linked to the Kinect Sports franchise.
For now though, it seems if you're looking for your Rare fix you'll have to make do with Conker's upcoming appearance in Project Spark.
Phil Spencer: Scalebound is alrready Playable, Still Interested in JRPGs
Japanese video game developer Platinum Games' Scalebound was one of the Xbox One's most exciting reveals during this year's edition of the E3 gaming trade show.
Fans of the Xbox have long been clamoring for more love for Japanese games, and it appears that Xbox head Phil Spencer is making a lot of right moves in his efforts to catch up to Sony's PlayStation 4.
The latest such initiative is getting Hideki Kamiya's Scalebound as an Xbox One exclusive, a fantasy game that mainly deals in hunting down huge monsters.
The E3 2014 trailer showed a scene with some gargantuan beasts chasing down a carefree hunter wearing headphones through the forest, culminating with a pretty noisy fight, some rad armor, some fire-breathing dragon action and a sneak peek at Magic: The Gathering's Progenitus. It could have been any other giant hydra though.
Phil Spencer took to Twitter to reveal more about the upcoming game, teasing fans that the game was already playable.
"Don't have the next PR event set, working on the game, we are playing the game but I'm not sure when we'll show playable or talk story," Spencer said.
He also expressed his excitement of working with Platinum Games and having added their creation to the Xbox One's portfolio.
"Getting to work with @platinumgames, for me, will be a highlight of XBOX One," Spencer tweeted.
He also revealed that the games that will be shown for the Xbox One at the upcoming Tokyo Game Show would "almost certainly" also become available in the west, stating that he was still interested in bringing Japanese role-playing games to the Xbox platforms, even though they hadn't been too successful on the Xbox 360.
He even admitted that part of the blame could lie with Microsoft not pushing them hard enough, which he probably intends to change in the near future.
He also mentioned that the Xbox team was already preparing for Gamescom, putting together the plan for the convention, but that the details weren't set in stone yet.
Although it would be nice to see the first gameplay demo of Scalebound revealed at Gamescom in August, it's more likely that a playable version of the game will be featured at the Tokyo Game Show in September.
Platinum Games' resume includes the 2009 surprise hit Bayonetta and the Metal Gear Rising: Revengeance hack-and-slash video game. They are also currently working on Bayonetta 2, a Nintendo Wii U exclusive game that is expected to launch worldwide in October this year.
Joseph Staten Writing and Narrative Design for Sunset Overdrive, Scalebound, and Crackdown
Joeseph Staten (The Lead Writer for all Halos except Halo 3 (Partly made it with somebody else, lead cinematics for Halo games and writer of some Halo books, one of the biggest Halo people back in the day ;P)
Senior Creative Director
Public Company; 10,001+ employees; MSFT; Computer Software industry
January 2014 – Present (6 months)
IP development, writing and narrative design for XBOX first-party games including Sunset Overdrive, Scalebound and Crackdown.
Interview on Phantom Dust
By Vampero • Posted in XBOX ONE	• Tagged Japan, JRPG, Microsoft, Microsoft Studios, Phil Spencer, Platinum Games, Xbox Empire, Xbox One
Head of Xbox: Phil Spencer Discusses New Role
I think he will do a great job !
Phil @XboxP3 Glad you are Head of Xbox now! Game focus guy is what @Xbox needs.11 years on XBL and I beta tested it! pic.twitter.com/fb4o5EdeO7
— Gaming Phanatic (@Vampero) April 4, 2014
Larry Hryb, Xbox Live's Major Nelson speaks with Phil Spencer about his new role as Head of Xbox. Topics include E3, fan feedback, and his plans to help lead Xbox going forward.
By Vampero • Posted in XBOX 360, XBOX ONE	• Tagged Gaming Phanatic, Major Nelson, Phil Spencer, Xbox, xbox live, Xbox One
Phil Spencer about Games for Gold on Xbox One !
I guess it is coming to Xbox One . Make sure you click the image to see the full tweet ! I know it says "Games for Gold" I was being a smart ass !!! Just saying !!!
By Vampero • Posted in XBOX ONE	• Tagged Games for Gold, Phil Spencer, Xbox, Xbox One
Phil Spencer is happy for new Xbox One gamers, are you ?
Tell me what your thoughts about Xbox One ?
@XboxP3 Update the dashboard, make streaming,recording & screenshots much easier please ! XO needs time to blossom ! #XboxOne @Xbox
— Christopher G. Morin (@Vampero) December 27, 2013
Phil Spencer leads Microsoft Studios and oversees creative teams around the world developing games.
By Vampero • Posted in XBOX ONE	• Tagged 2013 Phil Spencer, Christopher G. Morin, Microsoft, Microsoft Studios, Phil Spencer, Video Games, Xbox One
Xbox One getting more EXCLUSIVES !
@TheLocksus Yea, we still have exclusives to reveal.
— Phil Spencer (@XboxP3) July 1, 2013
By Vampero • Posted in XBOX ONE	• Tagged Microsoft, Phil Spencer, Twitter, Xbox One


text:
Home / Unlabelled /
Kristen Stewart Says Women Should "Do Something" Instead Of Complain About Gender Inequality In Hollywood!
Kristen Stewart isn't afraid to ruffle a few feathers!
In Hollywood, one of the most controversial topics today is gender equality. As we reported, readers were shocked when they learned that The X-Files tried to pay Gillian Anderson half of what they offeredDavid Duchovny!
Related: Kristen Stewart's Leather Outfit Will Leave You Speechless!
Recently, KStew visited the Variety Studio in Sundance to promote her new film Certain Women, and was asked about the issue. Let's just say her response may surprise you.
First, the 25-year-old concedes that she is a highly paid, in-demand actress who hasn't experienced the same prejudices that other thespians have faced.
"It's hard for me to speak to that, because, it's awkward, I'm so fucking lucky and so stimulated and driven, like not bored, and I have something in front of me all the time. It sounds weird for me to sit around and be like, 'It's not fair!' Guys make more money because their movies make more money. Let's start making more movies. It makes sense."
However, the Los Angeles-native doesn't believe the solution is discontent; the answer is action!
"Instead of sitting around and complaining about that, do something… Go write something, go do something."
Although the Twilight star acknowledges that this advice is easier said than done, she is totally over this conversation.
"And that's easy to say… Like, f–k, it's hard to get movies made. It's a huge luxury. Who gets to just make movies? But that subject is just so prevalently everywhere right now, and it's boring."
Whether you agree or disagree, you have to respect the fact that she speaks her mind.
To hear her full response, ch-ch-check out the clip (below)!
Reviewed by Admin Xclusive on January 26, 2016 Rating: 5


text:
'A generational talent': Rihanna to perform Super Bowl half-time show | Super Bowl
September 26, 2022 by StarNews
US singer Rihanna will perform the coveted Super Bowl half-time show in February 2023, after declining an invitation in 2019 Super Bowl out of solidarity with Colin Kaepernick.
The announcement was made on Sunday by the NFL. Rihanna posted an image on Instagram of an outstretched arm holding an NFL football.
"Rihanna is a generational talent, a woman of humble beginnings who has surpassed expectations at every turn," said Jay-Z in a statement; the hip hop artist's entertainment agency, Roc Nation, is an executive producer of the half-time show. "A person born on the small island of Barbados who became one of the most prominent artists ever. Self-made in business and entertainment."
The Super Bowl will take place at State Farm Stadium in Glendale, Arizona, on 12 February. After years of Pepsi's sponsorship, the upcoming half-time show will be sponsored by Apple Music.
Rihanna earlier said she turned down a similar opportunity for the 2019 Super Bowl, which was ultimately headlined by Maroon 5. At the time, many artists voiced support for Kaepernick, the former San Francisco 49ers quarterback who protested police brutality against Black people and minorities by kneeling during the national anthem in 2016.
"I couldn't dare do that. For what?" Rihanna told Vogue in 2019. "Who gains from that? Not my people. I just couldn't be a sellout. I couldn't be an enabler. There's things within that organization that I do not agree with at all, and I was not about to go and be of service to them in any way," she said of the league.
Kaepernick accused the NFL of colluding to keep him out of the league, in a case that was eventually settled in early 2019.
In 2019, the NFL partnered with Roc Nation (which manages Rihanna) to help pick performers for the Super Bowl, and strategize the half-time show. The widely acclaimed 2022 show featured Dr. Dre, Snoop Dogg, Eminem, Kendrick Lamar and Mary J. Blige.
With sales of more than 250 million records worldwide, Rihanna ranks as one of the bestselling female artists ever. Her last album was 2016's Anti; Rihanna last performed publicly at the Grammy awards in 2018.
In the years since, Rihanna has occasionally teased her music return. Earlier this year, she had her first child with the rapper ASAP Rocky.
Man City and Crystal Palace BOTH paid out as winners by bet365 due to early pay out offer
Darren Till was 'arrested for drink driving in Sweden in July'
David Beckham Slammed For PR Video Praising 'Perfect' Qatar
Spain vs Switzerland, UEFA Nations League: When And Where To Watch Live Telecast, Live Streaming
'House of the Dragon' just revealed the show's Littlefinger
Shop the Best Outfits From Netflix's Do Revenge


The faculty in our pediatric oncology, hematology, bone marrow transplantation and cell therapy programs on the Anschutz Medical Campus are nationally recognized for excellence in the diagnosis, treatment and research of cancer and blood disorders. This team works closely with our fellows to pursue research, explore new treatments and provide exceptional care for patients. We train our fellows to be future leaders in the field by offering world-class clinical and research opportunities within our Pediatric Hematology Oncology Fellowship Program.
Our Hematology Oncology Fellowship Program offers fellows graduate-level training in clinical science with the opportunity to pursue a doctorate or master's degree during fellowship.
Because of our program's exceptional training and education, in the past 20 years, more than 85% of our fellows have entered and stayed in academic medical careers, one of the highest percentages in the country.
We train fellows in the scientific and clinical aspects of hematology and oncology in preparation for a career in academic medicine. Our program emphasizes excellence in clinical care and focuses on the physician-scientist model, with numerous faculty members serving as role models.
During the fellowship, each fellow acquires clinical expertise and procedural skills required for diagnosis and treatment of patients with hematologic and oncologic disorders. Each fellow also selects a research mentor and develops research skills, specifically learning the methods of careful, controlled scientific inquiry. Our fellowship is designed as a three-year training program, with a clinical emphasis during the first year and a research emphasis in the latter two years.
Our program is accredited by the Accreditation Council of Graduate Medical Education.
Within the Hematology Oncology Fellowship Program, we encourage our fellows to pursue a wide variety of research interests. If you already know what your research interest is, we can put you in touch with faculty who share that interest.
Fellows can conduct research on the Anschutz Medical Campus at the University of Colorado School of Medicine or at other nearby institutions, such as the National Jewish Medical and Research Center, Colorado University Boulder and Colorado State University's veterinary school.
Our fellows gain experience in oncology, hematology, neuro-oncology, bone marrow transplantation and experimental therapeutics. We have faculty members who are national leaders in each of these areas, with particularly strong programs in leukemia, experimental therapeutics, hemostasis and thrombosis, brain tumors and stem cell transplantation.
U.S. News & World Report consistently ranks our Center for Cancer and Blood Disorders among the best programs in the nation, in part thanks to its state-of-the-art facility. Our Center occupies an entire floor of our hospital on the Anschutz Medical Campus and hosts a dedicated hematology, oncology and bone marrow transplant inpatient unit with an adjacent outpatient clinic and infusion center.
We are supported by excellent radiology and pathology services and we can access support from all our pediatric subspecialties, as well as resources at neighboring University of Colorado Hospital when needed. With a dedicated lead-lined room, we're one of the few centers in the country that can offer metaiodobenzylguanidine (MIBG) treatment to our neuroblastoma patients. We're also an FDA-designated Center of Excellence, which allows us to offer clinical trials and experimental therapeutics that are only available at a handful of institutions.
Our accredited Pediatric Hematology Oncology Fellowship Training Program lasts for 36 months, at which point fellows graduate and become board-eligible. For fellows interested in pursuing their research beyond that three-year period, we offer an option for an additional one to two years in our pediatric hematology oncology research fellowship. Some fellows choose this option to allow time to successfully obtain grant support as they develop into independent investigators.
Upon completion of the 36 month ACGME-accredited pediatric hematology oncology fellowship, we also offer one-year specialized fellowship opportunities available in bone marrow transplantation, neuro-oncology, non-malignant hematology, experimental therapeutics and transfusion medicine. These opportunities allow trainees to gain additional experience and expertise in a specific area of our subspecialty.
The Brent Eley Foundation, in collaboration with the Center for Cancer and Blood Disorders at Children's Colorado, hosts an annual guest speaker to address our medical community on developments in pediatric cancer research and treatments. The Brent Eley Visiting Professor lectures at both the UCHealth Cancer Center and Children's Colorado.
The Hays Hematology Symposium was started by the Center for Cancer and Blood Disorders at Children's Colorado to honor the clinical work of Dr. Taru Hays, a faculty member and pillar of general hematology in the Rocky Mountain region. Since the inception of the Hays Symposium in 2016, guests have included Donna DiMichele, Michael Jordan, Patrick Leavey, Neal Young and Tom Coates. The guests provide an expert lecture in their field, present at pediatric grand rounds at Children's Colorado and meet with fellows to discuss career development and career mentorship. In keeping with Dr. Hays' strong dedication to providers in and around the region, Children's Colorado staff and community providers from three states are included in the invitation and activities of the day.
The William Hathaway Visiting Professor is the guest speaker at the Center for Cancer and Blood Disorders Annual Research Retreat in Aspen. The goal of the retreat is to focus on career development of fellows and junior faculty. The Hathaway Visiting Professor opens the retreat with a keynote talk on his or her area of expertise to provide an example of success in their field. After that, the fellows and junior faculty present their research and plans, with sufficient time after each talk for discussion and feedback. The retreat provides group activities to encourage informal interactions and discussions, and dedicated time for fellows to spend with the Hathaway Visiting Professor to gain career and scientific guidance.
Our annual Spring Research Symposium gives fellows regular feedback on their progress and goals. Each fellow presents an update of their research project. Following their presentations, research and clinical faculty provide feedback to assist with the future direction of their projects. This venue provides a great opportunity for fellows to practice their presentation skills in a friendly setting and for members of the section to hear about research going on within our program.
Children's Colorado at Anschutz Medical Campus is located in Aurora, just nine miles east of downtown Denver and only a mile south of I-70, which provides access to all the Rocky Mountains have to offer.
Colorado is well known for its natural beauty, world-class hiking, biking, rock-climbing and skiing. Mountain life is just a short drive away for fellows on the Anschutz Medical Campus, allowing you to enjoy a weekend on the slopes or a day trip to your favorite hiking trail. Denver is a vibrant city with a thriving downtown, leading museums, a beautiful performing arts complex and great restaurants, night life and professional sports teams.


Home › Travel Tips › Travel Health › Malaria And Dengue Fever.
There are a wide variety of mosquito borne diseases that can affect travellers and have a seriously negative affect on their health as well as their gap year adventure, but perhaps the two most common, and most well known, are malaria and dengue fever. This article will take you through the basics of what you need to know before you go.
Malaria is one of the biggest mosquito borne diseases that still affects travellers and is a disease that is dangerous not just because of the impact it has on travellers health, but the high level of misinformation and misunderstanding that so many travellers have about it.
There are essentially four types of plasmodium parasites.
Malaria is prevalent throughout tropical and sub tropical regions, and outbreaks of various intensities and length are common in many countries throughout these regions, so the 'danger zones' of the at risk areas can often wax and wane.
Symptoms of Malaria include sever flu like symptoms such as shivering, coldness, a dull muscular ache, mild to severe fever, rash, headaches, diarrhoea and vomiting. They can occur anytime, most often up to fifteen days after the actual bite but can in some people take up to 4 weeks or in some cases even up to a year.
The big danger of these initial flu like symptoms is that they are similar to a wide variety of other diseases and can be very difficult to actually recognise as Malaria. This means that anyone who has contracted malaria runs the risk of not realising it or brushing it off if the symptoms are mild enough, and if not treated promptly it does have the potential to cause serious long term damage to the liver or even be fatal.
Diagnosis can only be made by health professionals taking a blood sample so it is important that you get yourself to adequate medical facilities as soon as possible if you suspect you have contracted Malaria.
There are basically only two ways you can try and prevent Malaria, by mosquito avoidance measures and anti malarial prophylaxis.
It is important that you check up to date information with your local GP surgery or travel clinic, the World Health Organisation or the CDC before you travel, and get up to date and accurate information specific to the region you are travelling to as different medications will be effective, or non effective, in different regions.
Anti malarials will also be prescribed based on your own specific medical history. Not all anti malarial medication is suitable for every destination, not every type of antimalarial suits everyone, some react very differently to others and of course there are always allergies and pre existing conditions to take into account. Which one you decide to take should be discussed with the practice nurse or physician in specialist clinics.
If you do contract Malaria, then hospitalisation is necessary. The only treatment is the same prophylaxis used to prevent Malaria, but if you have taken preventative prophylaxis and contracted Malaria anyway (they are not always 100% effective), then the treatment is often quicker and much easier, where a different antimalarial, or even a combination, will be used to treat you.
If medical help is sought quickly enough then full recovery is possible.
In many ways dengue fever is as prevalent as Malaria, but is often ignored by many travellers, if they have even heard of it at all.
Dengue fever is a viral infection transmitted by the bite of an infected Aedes aegypti or more rarely the Aedes albopictus mosquito. Any mosquito that bites during the daylight hours has a chance of carrying the disease. It is becoming increasingly problematic throughout the tropical and sub tropical world from South America to Asia, and has become a major international public health concern. Serious intermittent outbreaks occur frequently right across South and Central America, Africa and Asia.
Symptoms can include flu like symptoms similar to the symptoms of Malaria, a mild to severe fever, rash, muscle, joint and bone pain, which can be extremely painful and has led to the nickname break bone fever.
There is no vaccine or cure for dengue fever and there is no treatment, but it is not fatal and will in the majority of cases usually resolve itself.
Dengue hemorrhagic fever (DHF) however is a more severe form of dengue and can sometimes be fatal if not recognised and medically managed by physicians and nurses quickly enough.
You should always check for recent outbreaks in areas you want to travel to and plan accordingly.
Mosquito avoidance measures are the best and only way to reduce the risk of getting bitten and contracting the disease. It is almost impossible to completely protect yourself, but by taking specific avoidance steps you can significantly reduce the risks.
There is no treatment or medication for dengue, the only thing that can be done if you contract it is to treat the symptoms. Stay well hydrated, rest and take analgesics for the pain.


text:
Amazon AWS Jobs in the East Midlands
Amazon AWS Vacancies
Permanent IT Jobs
Contract IT Jobs
6 months 3 months
to 18 July 2019
The following table provides summary statistics for permanent job vacancies advertised in the East Midlands with a requirement for Amazon AWS skills. Included is a benchmarking guide to the salaries offered in vacancies that have cited Amazon AWS over the 6 months to 18 July 2019 with a comparison to the same period in the previous 2 years.
England > East Midlands
Same period 2018
Rank 22 30 73
Rank change year-on-year +8 +43 +21
Permanent jobs citing Amazon AWS 381 345 197
As % of all permanent IT jobs advertised in the East Midlands 9.37% 6.75% 3.53%
As % of the Cloud Services category 32.73% 27.56% 24.66%
Number of salaries quoted 315 298 180
East Midlands median annual salary £47,500 £47,500 £50,000
Median salary % change year-on-year - -5.00% +17.65%
10th Percentile £32,500 £32,125 £29,175
England median annual salary £65,000 £60,000 £60,000
% change year-on-year +8.33% - +9.09%
Amazon AWS is in the Cloud Services category. The following table is for comparison with the above and provides summary statistics for all permanent job vacancies advertised in the East Midlands with a requirement for cloud computing skills.
All Cloud Skills
Permanent vacancies with a requirement for cloud computing skills 1,164 1,252 799
As % of all permanent IT jobs advertised in the East Midlands 28.62% 24.50% 14.31%
Number of salaries quoted 943 1,059 673
Median salary % change year-on-year -2.30% +2.35% +6.25%
% change year-on-year +4.76% +5.00% -
Job Vacancy Trend in the East Midlands
Job postings citing Amazon AWS as a percentage of all IT jobs advertised in the East Midlands.
Salary Trend in the East Midlands
This chart provides the 3-month moving average for salaries quoted in permanent IT jobs citing Amazon AWS in the East Midlands.
Salary Histogram in the East Midlands
The salary distribution of IT jobs citing Amazon AWS in the East Midlands over the 6 months to 18 July 2019.
Job Locations in the East Midlands
The table below looks at the demand and provides a guide to the median salaries quoted in IT jobs citing Amazon AWS within the East Midlands region over the 6 months to 18 July 2019. The 'Rank Change' column provides an indication of the change in demand within each location based on the same 6 month period last year.
Rank Change
on Same Period
IT Job Ads
Nottinghamshire +8 230 £55,000 +10.00% 37
Leicestershire +25 80 £40,000 -20.00% 21
Northamptonshire +8 40 £75,000 +42.86% 9
Derbyshire -9 25 £42,500 -12.82% 13
Lincolnshire -3 7 £39,500 +25.40% 7
Top 30 Co-occurring IT Skills in the East Midlands
For the 6 months to 18 July 2019, IT jobs citing Amazon AWS also mentioned the following skills in order of popularity. The figures indicate the absolute number co-occurrences and as a proportion of all permanent job ads across the East Midlands region with a requirement for Amazon AWS.
1 204 (53.54%) Agile Software Development
2 202 (53.02%) Microsoft Azure
3 128 (33.60%) Java
4 124 (32.55%) JavaScript
5 119 (31.23%) Web Services
6 105 (27.56%) Linux
7 99 (25.98%) Windows
8 98 (25.72%) Microsoft
9 91 (23.88%) SQL
10 88 (23.10%) Python
11 86 (22.57%) Docker
12 83 (21.78%) Finance
13 82 (21.52%) HTML
14 81 (21.26%) C#
15 78 (20.47%) Degree
16 76 (19.95%) .NET
17 75 (19.69%) Node.js
18 74 (19.42%) CSS
19 70 (18.37%) Test Automation
19 70 (18.37%) DevOps
19 70 (18.37%) AngularJS
20 64 (16.80%) Public Cloud
20 64 (16.80%) Git (software)
21 61 (16.01%) Jenkins
22 58 (15.22%) Active Directory
23 57 (14.96%) Google Cloud Platform
24 55 (14.44%) Microservices
24 55 (14.44%) VMware
24 55 (14.44%) JIRA
25 54 (14.17%) Kubernetes
Co-occurring IT Skills in the East Midlands by Category
The follow tables expand on the table above by listing co-occurrences grouped by category. The same job type, locality and period is covered with up to 20 co-occurrences shown in each of the following categories:
Application Platforms
Communications & Networking
Database & Business Intelligence
Libraries, Frameworks & Software Standards
Processes & Methodologies
Quality Assurance & Compliance
1 19 (4.99%) Apache Spark
2 17 (4.46%) Confluence
3 16 (4.20%) Elasticsearch
4 9 (2.36%) JBoss
4 9 (2.36%) WebLogic
5 7 (1.84%) Skype for Business
6 6 (1.57%) Apache
6 6 (1.57%) SharePoint
7 5 (1.31%) OpenStack
7 5 (1.31%) Tomcat
8 4 (1.05%) MS Exchange
8 4 (1.05%) nginx
9 3 (0.79%) CMS
9 3 (0.79%) iPlanet
10 2 (0.52%) Exchange Server 2010
10 2 (0.52%) WebSphere
11 1 (0.26%) Mule
11 1 (0.26%) Oracle Workflow
11 1 (0.26%) WordPress
1 2 (0.52%) HipChat
1 2 (0.52%) Microsoft Office
2 1 (0.26%) Adobe XD
2 1 (0.26%) Figma
2 1 (0.26%) Microsoft Excel
2 1 (0.26%) Microsoft PowerPoint
2 1 (0.26%) Sketch
1 8 (2.10%) SAP ERP
2 3 (0.79%) Dynamics AX
2 3 (0.79%) Magento
3 2 (0.52%) NetSuite
4 1 (0.26%) Oracle EBS
4 1 (0.26%) Oracle EBS R12
4 1 (0.26%) Oracle iProcurement
2 57 (14.96%) Google Cloud Platform
3 51 (13.39%) Office 365
4 35 (9.19%) Serverless
5 27 (7.09%) AWS CloudFormation
6 26 (6.82%) IaaS
7 25 (6.56%) AWS Lambda
8 21 (5.51%) Azure Active Directory
8 21 (5.51%) SaaS
9 15 (3.94%) GitHub
9 15 (3.94%) PaaS
10 10 (2.62%) Amazon EC2
11 9 (2.36%) Cloud Computing
12 8 (2.10%) Amazon S3
13 7 (1.84%) Power Platform
13 7 (1.84%) Virtual Private Cloud
14 6 (1.57%) AWS CodePipeline
14 6 (1.57%) npm
14 6 (1.57%) OpenShift
15 5 (1.31%) Amazon Kinesis
1 24 (6.30%) Firewall
2 16 (4.20%) WAN
3 14 (3.67%) DNS
4 12 (3.15%) VPN
5 9 (2.36%) DHCP
6 8 (2.10%) LAN
7 7 (1.84%) Skype
7 7 (1.84%) VoIP
8 6 (1.57%) SMS
9 5 (1.31%) HTTP
9 5 (1.31%) SAN
9 5 (1.31%) TCP/IP
10 4 (1.05%) SSL
11 2 (0.52%) HTTPS
11 2 (0.52%) Kerberos
11 2 (0.52%) Wireless
12 1 (0.26%) Cisco ASA
12 1 (0.26%) Cisco Nexus
12 1 (0.26%) HSRP
12 1 (0.26%) SSH
1 39 (10.24%) SQL Server
2 34 (8.92%) MySQL
3 33 (8.66%) Big Data
4 20 (5.25%) Hadoop
5 15 (3.94%) MongoDB
6 14 (3.67%) Amazon DynamoDB
7 12 (3.15%) NoSQL
8 11 (2.89%) Amazon Aurora
8 11 (2.89%) Amazon RDS
9 10 (2.62%) MariaDB
10 9 (2.36%) HBase
10 9 (2.36%) SQL Server Integration Services
11 8 (2.10%) Looker
11 8 (2.10%) SQL Server 2012
12 7 (1.84%) Data Warehouse
12 7 (1.84%) PostgreSQL
12 7 (1.84%) Power BI
13 6 (1.57%) BusinessObjects
13 6 (1.57%) Data Lake
13 6 (1.57%) SQL Server Analysis Services
1 64 (16.80%) Git (software)
2 61 (16.01%) Jenkins
3 55 (14.44%) JIRA
4 37 (9.71%) Selenium
5 27 (7.09%) Cucumber
6 24 (6.30%) WebDriver
7 17 (4.46%) Maven
8 14 (3.67%) JMeter
8 14 (3.67%) SoapUI
9 13 (3.41%) Visual Studio
10 11 (2.89%) Gradle
10 11 (2.89%) Subversion
11 10 (2.62%) Octopus Deploy
11 10 (2.62%) Sonatype Nexus
12 9 (2.36%) Bitbucket
13 8 (2.10%) webpack
14 7 (1.84%) Gatling
14 7 (1.84%) Jasmine
14 7 (1.84%) Protractor
15 6 (1.57%) GitLab
1 83 (21.78%) Finance
2 52 (13.65%) Retail
3 24 (6.30%) Marketing
4 20 (5.25%) Telecoms
5 18 (4.72%) Manufacturing
6 13 (3.41%) Electronics
7 3 (0.79%) Banking
8 2 (0.52%) Games
9 1 (0.26%) Aerospace
9 1 (0.26%) Automotive
9 1 (0.26%) Financial Institution
9 1 (0.26%) Military
1 139 (36.48%) Developer
2 43 (11.29%) Architect
3 39 (10.24%) Java Developer
4 31 (8.14%) C# Developer
5 29 (7.61%) Cloud Engineer
6 27 (7.09%) Senior Developer
7 26 (6.82%) DevOps Engineer
8 25 (6.56%) .NET Developer
9 24 (6.30%) AWS Developer
9 24 (6.30%) Full Stack Developer
9 24 (6.30%) Software Developer
10 22 (5.77%) C# .NET Developer
11 21 (5.51%) Infrastructure Engineer
12 20 (5.25%) Lead Developer
12 20 (5.25%) Solutions Architect
13 18 (4.72%) Analyst
14 14 (3.67%) Automation Tester
14 14 (3.67%) AWS Engineer
14 14 (3.67%) Java Engineer
14 14 (3.67%) Tester
2 82 (21.52%) HTML
3 76 (19.95%) .NET
4 75 (19.69%) Node.js
5 74 (19.42%) CSS
6 70 (18.37%) AngularJS
7 48 (12.60%) React
8 43 (11.29%) Spring
9 41 (10.76%) HTML5
10 33 (8.66%) RESTful
11 31 (8.14%) J2EE
12 30 (7.87%) REST
13 28 (7.35%) OAuth
14 26 (6.82%) SAML
15 25 (6.56%) .NET Core
16 20 (5.25%) Vue.js
17 14 (3.67%) ASP.NET Web API
17 14 (3.67%) CSS3
17 14 (3.67%) SOAP
17 14 (3.67%) Twitter Bootstrap
1 64 (16.80%) Public Cloud
2 39 (10.24%) Virtual Team
3 38 (9.97%) Data Centre
4 34 (8.92%) Self-Motivation
5 18 (4.72%) Greenfield Project
6 15 (3.94%) Enterprise Software
6 15 (3.94%) User Experience
7 12 (3.15%) Hybrid Cloud
7 12 (3.15%) Linux Command Line
7 12 (3.15%) Mobile App
8 9 (2.36%) Cloud Native
8 9 (2.36%) Data Structures
8 9 (2.36%) NHS
9 7 (1.84%) Analytical Skills
9 7 (1.84%) Management Information System
10 5 (1.31%) Private Cloud
11 4 (1.05%) Algorithms
12 2 (0.52%) Enterprise Storage
12 2 (0.52%) PKI
12 2 (0.52%) Social Media
3 29 (7.61%) Windows Server
4 22 (5.77%) Windows 10
5 15 (3.94%) Windows Server 2012
6 14 (3.67%) Red Hat Enterprise Linux
7 8 (2.10%) Unix
8 7 (1.84%) Ubuntu
9 6 (1.57%) AIX
9 6 (1.57%) Android
10 5 (1.31%) Apple iOS
10 5 (1.31%) CentOS
10 5 (1.31%) Windows 8
11 3 (0.79%) HPUX
12 2 (0.52%) Amazon Linux
12 2 (0.52%) Mac OS
12 2 (0.52%) Windows Server 2008
13 1 (0.26%) Debian
13 1 (0.26%) FreeRTOS
2 70 (18.37%) DevOps
2 70 (18.37%) Test Automation
3 55 (14.44%) Microservices
4 45 (11.81%) Scrum
5 39 (10.24%) TDD
6 38 (9.97%) Computer Science
7 37 (9.71%) Unit Testing
8 34 (8.92%) Software Engineering
9 33 (8.66%) Analytics
10 32 (8.40%) Business Intelligence
10 32 (8.40%) Mentoring
11 30 (7.87%) Coaching
11 30 (7.87%) Continuous Integration
11 30 (7.87%) ITIL
12 27 (7.09%) BDD
12 27 (7.09%) Problem-Solving
13 26 (6.82%) Cybersecurity
14 25 (6.56%) Identity Access Management
15 23 (6.04%) Migration
4 88 (23.10%) Python
5 81 (21.26%) C#
6 33 (8.66%) PowerShell
7 27 (7.09%) PHP
8 26 (6.82%) Bash Shell
9 19 (4.99%) Java 8
10 12 (3.15%) ES6
10 12 (3.15%) Go
11 11 (2.89%) Ruby
11 11 (2.89%) Scala
12 9 (2.36%) Perl
13 8 (2.10%) C++
14 7 (1.84%) ES7
14 7 (1.84%) T-SQL
14 7 (1.84%) TypeScript
15 6 (1.57%) VBScript
16 5 (1.31%) R
1 78 (20.47%) Degree
2 27 (7.09%) Microsoft Certification
3 26 (6.82%) Master's Degree
4 19 (4.99%) CISM
4 19 (4.99%) CISSP
5 16 (4.20%) Computer Science Degree
6 15 (3.94%) CISA
6 15 (3.94%) CRISC
7 13 (3.41%) MCSA
7 13 (3.41%) MCSE
8 10 (2.62%) AWS Certification
8 10 (2.62%) ISEB
8 10 (2.62%) PMI Certification
8 10 (2.62%) PMP
9 8 (2.10%) ISTQB
9 8 (2.10%) ISTQB Foundation Certification
10 7 (1.84%) Cisco Certification
11 6 (1.57%) VMware Certified Professional (VCP)
12 5 (1.31%) Citrix Certification
13 3 (0.79%) CCNP
1 26 (6.82%) QA
2 17 (4.46%) GDPR
3 15 (3.94%) ISO/IEC 27001
4 10 (2.62%) COBIT
4 10 (2.62%) PCI DSS
5 9 (2.36%) SLA
6 4 (1.05%) NIST
7 1 (0.26%) ISO 9001
7 1 (0.26%) NCSC
1 86 (22.57%) Docker
2 58 (15.22%) Active Directory
3 50 (13.12%) Hyper-V
4 36 (9.45%) VMware Infrastructure
5 6 (1.57%) Citrix Hypervisor
5 6 (1.57%) VMware ESXi
5 6 (1.57%) vSphere
6 4 (1.05%) HDFS
7 3 (0.79%) Varnish
8 2 (0.52%) Apache ZooKeeper
8 2 (0.52%) Firmware
8 2 (0.52%) XenApp
9 1 (0.26%) Apache Flume
9 1 (0.26%) Microsoft App-V
9 1 (0.26%) Oracle Clusterware
9 1 (0.26%) Oracle RAC
9 1 (0.26%) Virtual Servers
1 54 (14.17%) Kubernetes
2 32 (8.40%) Ansible
3 29 (7.61%) Terraform
4 23 (6.04%) SCCM
5 22 (5.77%) Opscode Chef
5 22 (5.77%) Puppet
6 16 (4.20%) Microsoft Intune
7 6 (1.57%) Single Sign-On
8 5 (1.31%) Nagios
9 4 (1.05%) Nessus
10 3 (0.79%) Icinga
11 2 (0.52%) Mesos
11 2 (0.52%) Oozie
12 1 (0.26%) BladeLogic
12 1 (0.26%) FortiGate
12 1 (0.26%) Grafana
12 1 (0.26%) Packer
12 1 (0.26%) Prometheus
12 1 (0.26%) SELinux
12 1 (0.26%) ZABBIX
2 55 (14.44%) VMware
3 38 (9.97%) Google
4 25 (6.56%) Oracle
5 24 (6.30%) Cisco
6 23 (6.04%) SAP
7 22 (5.77%) ForgeRock
8 16 (4.20%) Red Hat
8 16 (4.20%) Tableau
9 15 (3.94%) Citrix
10 11 (2.89%) SaltStack
11 10 (2.62%) MicroStrategy
12 8 (2.10%) Sitecore
12 8 (2.10%) Snowplow
12 8 (2.10%) Splunk
12 8 (2.10%) Talend
13 6 (1.57%) Apple
13 6 (1.57%) HP
13 6 (1.57%) New Relic
14 5 (1.31%) IBM
87 Amazon AWS job vacancies in the East Midlands
Amazon AWS Vacancies in the East Midlands| Privacy Policy| Copyright| Disclaimer| About us| Contact us
Last Updated Thursday 18 July 2019
2004-2019 IT Jobs Watch Ltd. Some rights reserved
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.


This Keg is adapted for secondary fermentation , tested for high pressure and fitted with a safety release valve, this system is compatible with all S30 and S20 cylinders, you can have one tap and many kegs for switching various beers.
If you would like to use 8g CO2 bulbs just add a S30 pin conversion pack and bulb holder.
The S30 kegs works best with the S30 stainless pump.
Category: Beer Barrels, Caps,tap,Seals ect, S30 Despensing System.	Tags: barrel, beer, cider, keg, lager, pump, s30 valve, stainless steel, tap.


Metrographics®, a full service commercial printer, needed a simple, yet easy way to thank customers for their business at the end of the year. As a holiday gift, they decided to give customers a $25 Dining Rewards Card redeemable at any restaurant of their choice.
Once recipients received their gift, they were directed to a custom-designed landing page that added even more branding to the promotion. Customers were asked a few customer service questions before entering their code, and once they gave their feedback, they were directed to the dining rewards platform where they got to choose their certificate. In addition to rewarding and thanking customers with exciting gifts, Metrographics got the opportunity to receive customer feedback that could help their business in the upcoming year.
This giveaway simplified rewarding and helped Metrographics achieve the customer service success they were looking for. Over half the population loves to dine out, so giving customers a night on the town was an excellent way for Metrographics to thank customers for their service.


Lately I have been reminded of how amazing life is in little ways I all too often take for granted. In fact the one moment that comes to mind today is the collection of memories from my recent trip to Point Pelee National Park. Around one last bend in the water at this beautiful Carolinian Forest, I paddled when my eyes were drawn to tall yellow blooms that popped up a foot out of the marsh. Up close and personal from a kayak, made this discovery breathtaking, and made me realize how experiencing things first hand instead of from a book really makes a difference.
The difference in me translates to a rush inside … the awe of discovering in the wild vs. just reading facts. Seeing and touching the large yellow water lily like flower in in its wild natural habitat and the photos I went away with, inspired me to satisfy my curiosity by investigating this mystery plant.
Before I knew it…after just a few strokes on the keyboard and there it was…the Yellow or American Lotus! Officially called Nelumbo Lutea, this plant is native to parts of Mexico, the Caribbean, and Honduras and across the South Eastern U.S. While no time frame was given, it seems that Native Americans or first Nations as they are called here carried the Lutea plants and seeds for food as they travelled north.
The northern end of the lovely native Lotus existing range is Pelee National park, where I experienced them. Considered rare here, extirpated in Delaware, threatened in New Jersey and threatened in Michigan, these beautiful flowers are yet another casualty to disappearing marshlands. In addition to marshlands, these aquatic plants are also found growing in lakes, swamps and ponds.
Like many other aquatic plants, these float on the top while anchored by their roots in the deep muck at the bottom. From these anchored roots, petioles or leave stems grow up to 2 metres in length , upwards through the water as they support the huge leaves circular leaves that float on the surface.
Although all parts of this plant act as part of a natural filtering system that helps clarify the water around it the circular leaves on top accomplish several function. First the leaves provide shade for its own roots as well as small aquatic animals. According to my research these leaves reach up to 43 centimetres in diameter, and certainly based on the size of my paddle, the ones I saw were at least this size if not larger.
When I first noticed the leaves from my kayak, the size blew me away. I did not realize they were circular and did not have the notch in them as do lily pads. The petiole of the Lotus is attached underneath the leaf about the middle whereas lily leaves attach to one side creating sort of a rounded heart.
Certainly watching the water bead up and roll across on the lotus leaves was fascinating, as water does not adhere to the leaves. Trying to capture the beads of water as they rolled back and forth was almost impossible, but of course I tried. While this fact did not seem radical at the time, further digging led me to data stating that the leaves have a slightly waxy surface which helps the small droplets form larger ones. This movement aided by nano scale groves and bumps that also help water movement that cleans the leaf surface. Fascinating!
It seems then, that the Lovely native Lotus cleans the water through its roots, shades and keeps the water cool for itself and other tiny aquatic creatures, is a source of food and provides a lovely flower to hold the seed pods for propagation. Certainly all plants provide food sources for insects and sometimes even small animals and humans.
In this case, Native Americans ate the Lotus in many ways. The rhizomes or tubers were usually steamed or often boiled as were the new still curled leaves. The seeds were eaten raw in their early immature state or roasted and peeled once the harder coating formed on the outside. As these parts and the tubers are primarily carbohydrate based this plant and even the flower ground for the dry seed were an important part of their diet.
The large seeds produced from this plant are formed at the heart of this magnificent pale yellow flower bud. After the 18-28 cm flower closes its 22-25 petals for one last time, the somewhat globoid or ball shaped seed pod begins to mature form green to a dark grayish colour. In nature, these seeds are also then eaten by muskrats, beavers and porcupines, while many fall to the bottom as their marble to peanut size makes transportation by birds difficult. Almost impervious to water because of a thick dark outer shell, they can sit on the bottom awaiting germination for years.
The sites below have a great deal of fascinating info on the seeds, plants and other aquatic plants.
The Yellow or American Lotus I have been describing is hardy to zone 4 unlike its Asian cousin Nelumbo Nucifera, which is tropical. The Nucifera ranges in colour from white to dark pink as is the national flower of India and Vietnam. From a Wikipedia photo I find it amazing to learn they are the only two plants in this species and are a half a world apart! In many Asian countries these aquatic plants are commercially grown, providing blooms for the florist industry, while the seeds, stems and other plant parts are a food source that is even exported to markets here in Canada.
From this genus of plants, composed only of these two geographically separated plants, there are now hybrids of different colours. Despite their resemblance to the water Lily family, they are not related, except perhaps by beautiful flowers rising from the water's surface.
From the large saucer shaped leaves that roll water across their smooth top, or that cup skywards, through the scented flower stage, to their shower head shaped seed pod, this native beauties are amazing! Currently with hybridization and export of plant materials worldwide, blooming flowers of all species,sizes and colours, are popular in backyard ponds and water features.
In addition to plants themselves, seeds to almost anything are also available on line. For the novice and even the experienced gardener directions on how to plant and even winterize lilies and other pond plants can be found on many sites. Both Sheridan Nursery's sites, as well as Canadian Gardening, are good sources of data.
The general directions may apply many plants, but in my mind but nothing could rival as seeing the wild Yellow Lotus, freely blowing in the wind! Of course as an avid gardener I wish I could grow one in a pond in my yard but then again I don't have one. Maybe a big barrel would do…no nix that! Maybe water gardens in the wild are more my style!
If inspiration has grabbed you, you have months to plan and dream about the ponds and aquatic plants in your future…good luck and happy gardening!
This entry was posted in Inspiration, marshlands, Pelee National Park, pond plants and tagged blooms, information site, inspiration, kayaking, pond plants, Water Lilys, Yellow Lotus by Linda. Bookmark the permalink.


Meals not specified, touring and excursions, visas, travel insurance and items of a personal nature. High Season supplements and weekend surcharges are applicable at certain times.
This hotel is centrally located close to various interesting sights of interest. Countless restaurants, shops, bars and links to the public transport network are to be found within the immediate vicinity.


Seven sailors were killed when the USS Fitzgerald struck a Philippine container ship in June. The Navy has blamed "inadequate leadership" for the crash.
The US Navy relieved several senior commanders of duty late Thursday over a deadly collision with a commercial container ship in June. The USS Fitzgerald struck the Philippine vessel off the coast of Japan, resulting in the death of seven US sailors.
Fortunately, no one aboard the ACX Crystal container ship was killed.
"The collision was avoidable, and both ships demonstrated poor seamanship," said the Navy's 7th Fleet in a statement, adding that "flawed" teamwork also led to the deadly crash.
Commanders Bryce Benson and Sean Babbitt, along with Master Chief Petty Officer Brice Baldwin have all been stripped of their duties, and more than a dozen other sailors will be punished for their conduct.
The Navy said that the trio had shown "inadequate leadership," but that it could not release specific details as the investigation into the accident was ongoing.
According to Admiral William Moran, vice chief of naval operations, the team responsible for keeping watch on the ship's bridge had "lost situational awareness," leaving them unprepared to respond in time once the container ship was spotted.
The crash occurred during the early morning hours of June 17, when the bow of the ACX Crystal smashed into the USS Fitzgerald's right side, flooding one of the berthing areas. Twenty-eight of the soldiers sleeping in the cabin were able to escape and were later rescued, but seven drowned as water flooded the area without 30 to 60 seconds of the collision.
The Japanese Navy, which aided in rescue operations, is conducting its own investigation separate from the US inquiry.
At least seven sailors were killed and three injured after a US Navy destroyer collided with a container ship off the coast of Japan. Officials have begun questioning crew about the cause of the crash.
The US Navy will replace its 7th Fleet commander, Vice Admiral Joseph Aucoin, after a string of collisions involving warships. Several sailors are missing after the latest incident off Singapore.
Rescue crews are searching for at least missing 10 sailors after the USS John S. McCain was damaged in a large-scale collision off Singapore. The Pentagon announced an intense probe into the US warships around the world.


text:
Discovering the epic places in kumaon
People die for a glimpse of Uttarakhand, a heart-touching place where all you can get is positivity and relaxation. Uttarakhand is divided into two regions ie. Kumaon and Garhwal. Both of the regions are quite famous for their immense beauty and culture.
Moving forward, I would like you to explore the Kumaon region.
Toh! Kripya apne mann roopi kursi ki paeti baandh lijiye, aur tanav mukt yatra karne ke liye tayyar hojaiye….
Starting from Haldwani which is known as 'Kumau Gate' Kumau is a vast and beautiful region of Uttarakhand. From wearing 'pichauda', the pride of every married woman to Murli, Bina, and hurka, Kumau gives a great vision of its beautiful culture. Apart from well-known places that are easily identifiable by the tourist, there are so many lesser-known salubrious hill stations.
Introducing you to some epic hill-stations of Kumaun which are so unique that they are all hidden from most of the tourists.
Does it happen to toy that you go to a new place and stay with your relatives at their house? Then you enjoy exploring the places and come back by the end of the day to relax.
Uttarakhand is well known for managing its relations with strangers too. Introducing you to Aaroham Resort, one of the Best Resorts near Bhimtal is the right place to stay with your family or friends. Aaroham gives you a welcoming feel with the warmth in nature of the staff and their luxurious hospitality. Ab Bhimtal ki baat ki hai to usii se shuru kartey hain!
At a height of 1200 meters above sea level, Bhimtal is the crown of the Kumaon region. The lake of Bhimtal is considered to be the largest lake in the area of Kumaun. Bhimtal with its beautiful location has a cafe in the middle of its lake that enhances its beauty more and more. Going in the middle of the lake by boating and capturing that wow beauty in your eyes is one of the things to look forward to in Bhimtal.
1638 m in height, Almora got its name from kilmora, a kind of beige. Situated on a 5-km-long ridge on Kashyap hills, Almora is well known for its delicious cuisines, unique handicraft, and of course its cultural heritage. You can enjoy the breathtaking beauty of sunrise and sunset as well at the Bright End Corner which is 2 kms from Almora.
Switzerland of India, Kausani is a backpacker's hub and a dreamland for anyone.
Kausani hill station which is located in the Bageshwar district of Uttarakhand is 51 km from Almora.
Nourished under the scabbard of the dark red sun and those green hills, Kausani is known for its captivating view of the great Himalayan peaks such as Nanda Devi, Trishul, and Panchachuli peaks.
'Queen of Meadows', Ranikhet is a hill station which is located at the height of 1,800 meters above sea level in the Almora District. In 1869, the British were the ones that established the headquarters of the Kumaon Regiment because of the British Raj. Ranikhet is quite famous for its Nanda Devi peak, fruit orchards, and temples.
Tucked at an elevation of 2,285 m above sea level, Mukteshwar is a lovely place situated in the Nainital district of Uttarakhand. Mukteshwar is famous for trekking, paragliding, and climbing. Mukteshwar Dham is named after the 350-year-old Shiva Temple called Mukteshwar Dham. It's bizarre as the hill station got its name from the credence that Lord Shiva killed a demon here and gave him Mukti.
Abbott Mount
A grotesque town, Abbott Mount is located in the Kali Kumaon region of Champawat district, Uttarakhand. A hospital by Doctor Morris who used to operate from the same building in the past. Abbott Mount is famous for its ghost stories where it is said that "Dr.Morris loves to do experiments with brains, so he killed many of the natives of that village for his experiment. And by now this place has become haunted! If you are someone who is looking for a thrill like this, Abbott Mount is your place!
Ab apni mann roopi kursi ki paeti khol lijiye! Aur kadmo ko badhaye, because these spectacular places are waiting for you. They are calling you before it's too late! Also don't forget about Aaroham Resorts, which is the Best Resort to stay in Bhimtal, kyuki anjaan jagah main apne pann ka ehsaas karane ka naam hai Aaroham Resorts.


text:
module Hello
  module Extensions
    module Deactivation

      def deactivate!
        # current_user.update! deactivated_at: Time.now
        # current_user.update! deactivated: true
        current_user.destroy!
      rescue ActiveRecord::RecordNotDestroyed => invalid
        raise ActiveRecord::Rollback
      end

      def success
        respond_to do |format|
          format.html { redirect_to '/' }
          format.json { render json: {deactivated: true}, status: :ok }
        end
      end

    end
  end
end

redpajama_set_name: RedPajamaGithub


Fans not lucky enough to get into a beta or player trial of SWTOR are hanging onto every little piece of news they can get to tell them something more about the game before release. Screen shot leaks from beta are one way that some of us are getting a sneak peek into the game and what it might hold. While it's important to remember that anything released early, especially from a beta, is subject to change. In fact, it probably will change- several times- before making it to the final version of the game.


Anna Pottery Stoneware Pig Flask w/ Elaborate Incised Railroad and River Map, 1895 -- Lot 299 -- July 22, 2017 Stoneware Auction -- Crocker Farm, Inc.
Anna Pottery Stoneware Pig Flask with Elaborate Incised Railroad Map, Incised "To my Old Friend / with a little good Old Rye / in a Pigs 1895", Anna, IL origin, 1895, molded flask in the form of a reclining pig with incised details to face and hooves, hole at rear, and anatomically-correct underside, the surface dipped in a chocolate-brown Albany slip glaze, and incised on one side with the inscription, "St Louis / To my Old Friend / with a little good Old Rye / in a Pigs- 1895". Remainder of pig incised with a map of the Midwestern U.S., including the following landmarks: Miss River, Chester, Gd Tower, Ava, Purcy, C & A, Rock Ilnd, Bellville, O & M, Springfld, Pinkville, murphystown, Alto, M & O, ICRR, Lasalle, C & R, Dwight, Bloomington, Decatur, Sandoval, I.C, mounds, Carbondale, Duquoin, Tamaroa, Centralia, Odin, Vincennes, Kanka, Pullman, Chicago, Big 4, Tunnel Hill, Mound City, cai[ro], Cincinnati, and Anna. This late-period pig features a finely-molded face with pronounced jowls as well an extensive map, which includes some landmarks uncommon to most Anna Pottery pig flasks. Provenance: A recently-surfaced example, consigned from the Northeastern U.S. An in-the-firing contact mark to top of pig. Loss to spout, which includes a loss to the "ro" in "cairo". L 7".


I love these quasi-holidays that the working stiff doesn't get a day off of, but the retailers take advantage of to blast a sale. Columbus Day might be my favorite. To celebrate(?) JC Penney is offering 20-60% OFF items throughout the store. The headline might be misleading, as this is all weekend and not just one day.
Get your clothing, home decor, kitchen appliances, drapes, shoes, accessories, and more before October 14. If you can, check out their doorbusters from 3pm-close tonight and 10am-1pm local time, but you'll have to go to the store to check it out.


Spoil your valentine with a beautiful Christina Re fine bone china mug in soft blush filled with fresh sesonal flowers.
Paired with Palm Beach Soy Candle in Vintage Gartdenia fragrance,this petie gift packs a punch!
Add Champagne or Chocolates to really impress!


text:
At Large in America
About AT LARGE in America
A Woman's (Museum) Work Is Never Done
By jscatlarge 2 Comments
Categories: Jared Cameron AT LARGE in America
Tags: Jim DeMint, Margaret Sanger, Meryl Streep, National Women's History Museum, Tom Coburn, Victoria Woodhull
Any husband knows: When the 'little ladies' set their minds on something, the best strategy is to say, 'yes, dear!' – especially if the gals are planning to pay for the project out of their 'pin money.'
Resistance is futile and the payback for opposition is certain and draconian, if not immediate.
This elemental concept seems to have eluded Senators Tom Coburn (R-OK) and Jim DeMint (R-SC), who, despite being listed as married to women in their bios, have banded together to block passage of legislation sponsored by fellow Republican Senator Susan Collins of Maine authorizing the sale of an embarrassingly small patch of unused federal land a block off the National Mall as the site for the National Women's History Museum.
Yes, I said 'sale.'
The government had planned to give away the very same land as a site for a national medical museum, but the docs grew weary of jumping through federal hoops for the property and decided to build in Atlanta, whose major attraction most probably lies in its distance from Senators Coburn, DeMint and their ilk.
But the Collins legislation is no government giveaway: It calls for selling the property to the Women's Museum and backers have money in the bank to pay cash for the site. (In the spirit of full disclosure, one of those backers is Mrs. AT LARGE, but I already told you I know on which side my bread is buttered.)
So what's and where's the senator's beef? Shiite Republicans like the Oklahoma-Carolina axis love privatization and where better to start than by milking the ladies for some unused federal land? (AT LARGE has always said, "If we're really worried about the national debt, why not sell the Grand Canyon or Oklahoma to some rich foreigners to pay our bills, but that's another story.)
Well, the two senators are too smart to say, "We don't want girls in our Mall tree house," or "If they get a museum, they'll be wantin' to vote next!"
Instead, the good-old boys club makes the scurrilous, nay, silly argument that passing the bill might somehow make the tax-payers liable if the project headed south in the future.
Why rely on my prose when I can quote Meryl Streep, the Women's Museum spokesperson who ponyed up a cool million of her own money for the project:
"We are not asking for a check — we want to give them a check."
Of course, nothing in Washington is as it seems. Deepthroat sources tell AT LARGE that the real reason these silly solons stand between the dames and their land deal are a bit more devious:
They're afraid that the new museum will 'glorify' two women who, well, were just not Tom and Jim's ideal 'tea party partners.'
And who are the two women who give these big, manly senators the vapors?
OK, Jane Fonda, I could understand. But Margaret Sanger and Victoria Woodhull? …gee guys!
Ms. Sanger was the mother of the birth control legalization movement. Sen. Coburn, an MD who has delivered more than 4000 babies, practiced family medicine before moving on to medicate/anesthetize the body politic. So, arguably, her anti-one-coupling-one-baby actions adversely impacted his customer pool and bottom line, but still…
Ms. Woodhull was a newspaper publisher, suffragette, and the first female candidate for president. She also espoused 'free love,' a stand certain to win her the admiration and gratitude of AT LARGE and all red-blooded American men, save only Messrs. DeMint and Colburn. Perhaps Sen. DeMint, in his previous life as head of a market research firm had a bad experience with a newspaper publisher, a presidential candidate…or free love.
It's not clear whether this whole problem could be solved to Coburn and DeMint's satisfaction by the Stalinist solution of airbrushing Sanger and Woodhull from the Women's Museum website. Or achieving a 'fair and balanced' museum by adding sections for, say, Sara Palin and Christine O'Donnell, both of whom are said to think Coburn and especially DeMint are 'the cat's meow.'
In any case, museum backers who have semi-deep pockets, a slew of Republican backers as well as Democrats and Meryl Streep on their side don't seem in the mood to airbrush history.
Instead, they're relying on public pressure to move the two naysaying senators and, failing that, hope to persuade Senate Majority Leader Harry (Profiles in Courage) Reid to man-up and take the extreme step of scheduling a vote on the measure after the election.
A woman's museum work is never done!
2 Responses to "A Woman's (Museum) Work Is Never Done"
1 r febbekk
A very well balanced yet insultingly patronizing article. You are a bit of an idiot for your mid-20th/ieval views on woman. But I like your support of the museum.
2 jscatlarge
I am a bit of an idiot, I admit, but, gee, when one is satirizing the mid-17th — or is is 15-century? — mentality of certain salons, well, one does what he/she must.
Alas, this fine, manly effort on my part failed to do much to move the senators, but — sorry, I can't come up with a sexist saw on female perserverence — museum supporters are not surrendering and this initial setback may be the start of something big.
« Wal-Mart and Women – Don't Play it Again, Sam!
The Day of the Inguina »
Jared Cameron
It is better to smoke a single candle that to curse the darkness


text:
<?php

// check if Creamy has been installed.
require_once('./php/CRMDefaults.php');
if (!file_exists(CRM_INSTALLED_FILE)) { // check if already installed
	header("location: ./install.php");
	die();
}

// Try to get the authenticated user.
require_once('./php/Session.php');
try {
	$user = \creamy\CreamyUser::currentUser();
} catch (\Exception $e) {
	header("location: ./logout.php");
	die();
}

// initialize session and DDBB handler
include_once('./php/UIHandler.php');
require_once('./php/LanguageHandler.php');
require_once('./php/DbHandler.php');
$ui = \creamy\UIHandler::getInstance();
$lh = \creamy\LanguageHandler::getInstance();
$colors = $ui->generateStatisticsColors();

// calculate number of statistics and customers
$db = new \creamy\DbHandler();
$statsOk = $db->weHaveSomeValidStatistics();
$custsOk = $db->weHaveAtLeastOneCustomerOrContact();

?>

        <meta charset="UTF-8">
        <title><?php print $ui->creamyHeaderName(); ?></title>
        <meta content='width=device-width, initial-scale=1, maximum-scale=1, user-scalable=no' name='viewport'>
        <link href="css/bootstrap.min.css" rel="stylesheet" type="text/css" />
        <link href="css/font-awesome.min.css" rel="stylesheet" type="text/css" />

        <link href="css/creamycrm.css" rel="stylesheet" type="text/css" />
        <?php print $ui->creamyThemeCSS(); ?>

		<?php print $ui->creamySnackbarCSS(); ?>

    <?php print $ui->creamyBody(); ?>

			<?php print $ui->creamyHeader($user); ?>

			<?php print $ui->getSidebar($user->getUserId(), $user->getUserName(), $user->getUserRole(), $user->getUserAvatar()); ?>

                        <?php $lh->translateText("home"); ?>
                        <?php $lh->translateText("your_creamy_dashboard"); ?>

 <?php $lh->translateText("home"); ?>

                    <?php
						require_once('./php/Updater.php');
						$upd = \creamy\Updater::getInstance();
						$currentVersion = $upd->getCurrentVersion();
						if (!$upd->CRMIsUpToDate()) {
					?>

<?php print $lh->translationFor("version")." ".number_format($currentVersion, 1); ?>

									<?php
									if ($upd->canUpdateFromVersion($currentVersion)) { // update needed
										$contentText = $lh->translationFor("you_need_to_update");
										print $ui->formWithContent(
											"update_form", 						// form id
											$contentText, 						// form content
											$lh->translationFor("update"), 		// submit text
											CRM_UI_STYLE_DEFAULT,				// submit style
											CRM_UI_DEFAULT_RESULT_MESSAGE_TAG,	// resulting message tag
											"update.php");						// form PHP action URL.
									} else { // we cannot update?
										$lh->translateText("crm_update_impossible");
									}
									?>

					<?php } ?>

						<?php print $ui->dashboardInfoBoxes($user->getUserId()); ?>

<?php $lh->translateText("customer_statistics"); ?>

	                            <?php if ($statsOk) { ?>
									<canvas id="lineChart" height="250"></canvas>
	                            <?php } else {
		                        	print $ui->calloutWarningMessage($lh->translationFor("no_statistics_yet"));
		                        } ?>

<?php $lh->translateText("current_customer_distribution"); ?>

		                            <?php if ($custsOk) { ?>

											<canvas id="pieChart" height="250"></canvas>

		                            <?php } else {
			                        	print $ui->calloutWarningMessage($lh->translationFor("no_customers_yet"));
			                        	print $ui->simpleLinkButton("no_customers_add_customer", $lh->translationFor("create_new"), "customerslist.php?customer_type=clients_1");
			                        } ?>

					<?php print $ui->hooksForDashboard(); ?>

            <?php print $ui->creamyFooter(); ?>

		<?php include_once "./php/ModalPasswordDialogs.php" ?>

		<?php print $ui->creamySnackbarJS(); ?>

		<?php if ($statsOk) { ?>

		<?php } ?>
		<?php if ($custsOk) { ?>

		<?php } ?>


text:
<?php

namespace soleil\UserBundle\Controller;

use FOS\UserBundle\Controller\SecurityController as BaseController;

use Symfony\Component\DependencyInjection\ContainerAware;
use Symfony\Component\HttpFoundation\Request;
use Symfony\Component\Security\Core\SecurityContextInterface;

use Symfony\Component\HttpFoundation\RedirectResponse;

class SecurityController extends BaseController
{
    public function loginAction(Request $request)
    {

        if($this->container->get('security.context')->isGranted('ROLE_ADMIN')){

            return new RedirectResponse($this->container->get('router')->generate('soleil_sous_site_accueil_admin'));

        }
        else{
            $response = parent::loginAction($request);
            return $response;
        }

    }

    /**
     * Renders the login template with the given parameters. Overwrite this function in
     * an extended controller to provide additional data for the login template.
     *
     * @param array $data
     *
     * @return \Symfony\Component\HttpFoundation\Response
     */

    protected function renderLogin(array $data)
    {
        //echo "surcharge login<br/>";

        $response = parent::renderLogin($data);
        return $response;

    }

}


text:
dec-1-en-4-yne
15-03-2019 to 21-03-2019
other: Guideline study performed under GLP. All relevant validity criteria were met.
Information as to the availability of the in vivo study is provided in 'attached justification'.
OECD Guideline 203 (Fish, Acute Toxicity Test)
other: Guidelines for the Testing of Chemicals, Effects on Biotic Systems, Version 2, 203 Fish Acute Toxicity Test, China Environmental Press, China (2013)
The test was generally conducted in accordance with or equivalent to the following: China HJ/T153 - 2004 Chemical Test Guideline stipulations and Chemical Registration Center of MEP. The Guidelines for the Testing of Chemicals, effects on Biotic Systems, 203 Fish Acute toxicity test [M]. Second Edition. Beijing: China Environmental Press. 2013: 30-36. The test was also completed under OECD TG 203: Fish Acute Toxicity Test (1992).
Details on sampling:
- Concentrations: 0 (Control), 1.0, 1.8, 3.2, 5.6 and 10 mg/L nominal (geometric series factor 1.778) ; with geometric mean measured equivalent concentrations of: 1.17, 1.99, 3.45, 5.83 and 10.8 mg/L, respectively.
- Sampling method: 50 mL extract from test solution. The actual concentrations were measured at 0 h, 96 h, and 24 h, 48 h, 72 h (after and before the renewal)
- Sample storage conditions before analysis: The test solutions of all test groups were filtered through 0.45 μm aqueous phase PES filter membranes (the first 5 mL - 10 mL filtrations were discarded). Filtrations of blank control were analysed directly and the filtrations of test item groups were diluted with acetonitrile for 2-fold before analysis. Samples were analysed immediately or were stored at 2- 8 °C in the dark within 48 hours.
- Method: 5400 mL test water was obtained in about 5 L narrow-mouthed bottle and 6.9 μL, 12.4 μL, 22.0 μL, 38.4 μL and 68.6 μL test item was added (calculated with relative density 0.787, the weight of test item was respectively: 5.4 mg, 9.8 mg, 17.3 mg, 30.2 mg and 54.0 mg). The test item could not be directly weighted due to suspected volatility. The test solutions were covered (glass stopper), with stirring for ca. 3 hours. The test solutions with nominal concentration of 1.0 mg/L, 1.8 mg/L, 3.2 mg/L, 5.6 mg/L and 10.0 mg/L were obtained and used in testing directly.
- Eluate: Not applicable.
- Differential loading: Not applicable.
- Controls: A negative/blank control without test item or reference item was also included. A previously conducted sensitivity test with potassium dichromate (positive control/reference item) was performed. Full information provided in the full study report.
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): Not applicable.
- Concentration of vehicle in test medium (stock solution and final test solution(s) or suspension(s) including control(s)): Not applicable.
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): In the definitive test there was no evidence of undissolved test item.
Danio rerio (previous name: Brachydanio rerio)
TEST ORGANISM
- Common name: Zebra fish (Brachydanio rerio)
- Strain: Not reported. Batch generation number FDr20180815-2
- Source: Recognised supplier (recorded in full study report) located in China.
- Age at study initiation (mean and range, SD): Not reported.
- Length at study initiation (length definition, mean, range and SD): Not reported. The body weight and total length of test fish in blank control were measured when the test was finished. The average and deviation of test fish total length and body weight were respectively 26.54 – 29.21 mm (mean = 27.99 +/- 0.98 mm ; meeting the requirement of 20.0±10.0 mm according to guideline) and 0.100 – 0.115 g (mean = 0.107 +/- 0.006 g). In the treated/control groups the loading was 0.138 6 g/L (i.e. < 1.0 g fish/litre).
- Method of breeding: Not reported.
- Feeding during test: No.
- Food type: Feeding was conducted during acclimation (daily - workdays) until 24-hours prior to test initiation.
- Amount: No feeding during exposure. Not applicable.
- Frequency: No feeding during exposure. Not applicable.
ACCLIMATION
- Acclimation period: 144 days (i.e. > 48 hours)
- Acclimation conditions (same as test or not): Yes. Same water quality, temperature 23 ± 2°C and photoperiod as used during the test (14 hours light; 10 hours dark). Oxygen concentration was in the range of the exposure duration (> 80% air saturation).
- Type and amount of food: Not reported.
- Feeding frequency: Daily (work-day); until 24 hours before the start of the test.
- Health during acclimation (any mortality observed): None reported (0% during 7 days pre-test).
In accordance with the OECD TG 203 guidelines.
135 mg/L expressed as CaCO3; Test water (dechlorinated water)
Temperature 21.9 - 23.7 °C during test period, the test was performed in a temperature controlled environment with continuous monitoring and was maintained at 23 ± 2°C.
Test water (dechlorinated water): pH 6.0 - 8.5 (actual: pH 8.19) as specified in China Guidelines for the testing of Chemicals (2nd Ed.) 203 test.
The pH was in the range of 7.96 - 8.28 during the study.
The test solutions were not aerated during the exposure. The dissolved oxygen concentration in the test solutions during the test was kept at not less than 60 % of the air saturation value. Measured range: 74 to 102% ASV during the definitive test.
- Preliminary range-finding test performed on semi-static test system: 0 (Control), 1.0, 3.0 and 10 mg/L nominal
During the range-finding test, the actual concentration of 1.0 mg/L, 3.0 mg/L and 10 mg/L test groups were analysed during the test period of 0 h and 24 h by HPLC
The cumulative mortalities of test fish in blank control and test item groups up to 10 mg/L respectively were 0%, 0%, 0%,0% and 100%, respectively
- Definitive test performed on semi-static test system with renewal every 24 hour intervals: 0 (Control), 1.0, 1.8, 3.2, 5.6 and 10 mg/L nominal (geometric series factor 1.778) ; with geometric mean measured equivalent concentrations of: 1.17, 1.99, 3.45, 5.83 and 10.8 mg/L, respectively.
During the test, the dissolved test item concentrations were analytically determined in the freshly prepared solution/medium (t=0h, 24h, 48h, 72 h) and in the aged medium/solution before renewal (t=24h*, 48h*, 72h*, 96h*)
- Test vessel: 5L narrow-mouth bottle with bottle cap
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: glass. 5400 Litre fill volume (minimum headspace ca. 0 mL); the report specifies 5 L narrow-mouth bottle but the actual volume is probably ca. 5400 mL
- Aeration: Not continuously aerated although DOC > 60% ASV during exposure.
- Type of flow-through (e.g. peristaltic or proportional diluter): Not applicable.
- Renewal rate of test solution (frequency/flow rate): Renewal every 24 hours.
- No. of organisms per vessel: Seven (7) per vessel
- No. of vessels per concentration (replicates): None.
- No. of vessels per control (replicates): One (1)
- No. of vessels per vehicle control (replicates): Not applicable.
- Biomass loading rate: < 1.0 g/L (Actual: 0.138 6 g/L).
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated Tap Water used in the test were purified by the reverse osmosis equipment. (Certified annually).
- Conductivity: Not reported. Typically, would be: Water: 500±100μs/cm) as specified in China Water quality standard for fisheries in GB-11607-89.
- Culture medium different from test medium: No.
- Intervals of water quality measurement: Every 24 hour intervals; before and after renewal
OTHER TEST CONDITIONS
- Adjustment of pH: None.
- Photoperiod: 14 hours photoperiod daily
- Light intensity: 1086 lx and 1165 lx on average
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortalities and abnormalities; measured at 24h, 48h, 72h and 96h as applicable.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.778
- Justification for using less concentrations than requested by guideline: Not applicable. Five concentrations used.
- Range finding study: Yes. 0 (Control), 1.0, 3.0 and 10 mg/L nominal
- Test concentrations: See above
- Results used to determine the conditions for the definitive study: Yes.
0.593 mg/L
meas. (geom. mean)
other: C.I. 0.874 - 1.64 mg/L
- Behavioural abnormalities: There were no abnormal responses of test fish in the blank control. Observed abnormal responses are reported in table 3.
- Observations on body length and weight: The body weight and total length of test fish in blank control were measured when the test was finished. The average and deviation of test fish total length and body weight were respectively 26.54 – 29.21 mm (mean = 27.99 +/- 0.98 mm ; meeting the requirement of 20.0±10.0 mm according to guideline) and 0.100 – 0.115 g (mean = 0.107 +/- 0.006 g).
- Mortality of control: None.
- Other adverse effects control: Yes. None reported.
- Abnormal responses: Observed abnormal responses are reported in table 3.
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: Speculated to be volatility driven (although test was conducted in a closed semi-static system).
- Effect concentrations exceeding solubility of substance in test medium: Not applicable.
- Results with reference substance valid? Yes
- 24h LC50: 250 (C.I. 214 - 291) mg/L
The LC50 values and the 95% confidence limits (LC5) at 24h, 72h and 96h after the start of the test were calculated by Probit Analysis software (US EPA: Probit Analysis Program Version 1.5). The LC50 value and the 95% confidence limits (L95) at 48h was calculated by Spearman-Karber software (US EPA: Spearman-Karber Program Version 1.5).
Table 1. Median Lethal Concentration (LC50) and 95% confidence limits
Recommended observation times
LC50 (mg/L)
95% confidence limits (mg/L)
0.882 – 1.64
#1: LC50 based on geometric mean measured concentrations
Table 2. Cumulative mortality
Cumulative mortality
Nominal Concentration
/ mg/L
Geometric Mean Measured concentration
Exposure duration (h)
Table 3. Observed abnormal responses
Visible abnormalities
Symptom / Survivors
RA(2)
AB(4)
IMM(7)
A: means no abnormality
RA : means reduction of activity
AB: means swimming at the bottom,
IMM: means immobilized at the bottom
The 96 hour LC50 for the test item to Danio rerio was determined to be 1.21 (C.I. 0.874 - 1.64) mg/L based on geometric mean measured concentrations.
The acute toxicity of the test item to Zebra fish (Danio rerio) was determined in a 96 hour semi-static test according to OECD TG 203 and the China Guidelines for the Testing of Chemicals, Effects on Biotic Systems, Version 2, 203 Fish Acute Toxicity Test (2013) under GLP. Based on the results of range finding tests the nominal concentrations of 0 (Control), 1.0, 1.8, 3.2, 5.6 and 10 mg/L nominal concentrations (geometric series with a factor of 1.778) were selected for exposure to fish groups of 7 individuals. The test item was renewed at 24 hour intervals within a 96 hour semi-static test system in response to ensuring adequate stability of exposure to test item. Observations were made at 3, 24, 48, 72 and 96 hours after the start of the exposure. Analytical measurements of test item concentration were made every 24 hours, pre- and post- medium renewal and the end of the exposure by HPLC-VWD analysis. Measured concentrations of old solutions could not be maintained within 80% - 120% of the initial concentrations during the relevant exposure period. On this basis effect levels were indicated based on geometric mean measured concentrations. The corresponding geometric mean measured concentrations were: 0 (control), 1.17, 1.99, 3.45, 5.83 and 10.8 mg/L, respectively. During the definitive test the water temperature was in the 21.3 - 23.7 °C, pH was 8 7.96 - 8.28 and air saturation was 74 to 102% ASV indicating that environmental conditions were adequately maintained. Behavioural abnormalities and biological effects were reported during the course of the study. No abnormalities were observed in the control group. All validity criteria were considered to be met. The 96h median LC50 was 1.21 (C.I. 0.874 - 1.64) based on geometric mean measured concentrations.
LC50 (fish) = 1.21 (C.I. 0.874 - 1.64) mg/L based on geometric mean measured concentrations, 96-hour, freshwater, OECD TG 203, 2019
Key study : OECD TG 203, 2019 : The acute toxicity of the test item to Zebra fish (Danio rerio) was determined in a 96 hour semi-static test according to OECD TG 203 and the China Guidelines for the Testing of Chemicals, Effects on Biotic Systems, Version 2, 203 Fish Acute Toxicity Test (2013) under GLP. Based on the results of range finding tests the nominal concentrations of 0 (Control), 1.0, 1.8, 3.2, 5.6 and 10 mg/L nominal concentrations (geometric series with a factor of 1.778) were selected for exposure to fish groups of 7 individuals. The test item was renewed at 24 hour intervals within a 96 hour semi-static test system in response to ensuring adequate stability of exposure to test item. Observations were made at 3, 24, 48, 72 and 96 hours after the start of the exposure. Analytical measurements of test item concentration were made every 24 hours, pre- and post- medium renewal and the end of the exposure by HPLC-VWD analysis. Measured concentrations of old solutions could not be maintained within 80% - 120% of the initial concentrations during the relevant exposure period. On this basis effect levels were indicated based on geometric mean measured concentrations. The corresponding geometric mean measured concentrations were: 0 (control), 1.17, 1.99, 3.45, 5.83 and 10.8 mg/L, respectively. During the definitive test the water temperature was in the 21.3 - 23.7 °C, pH was 8 7.96 - 8.28 and air saturation was 74 to 102% ASV indicating that environmental conditions were adequately maintained. Behavioural abnormalities and biological effects were reported during the course of the study. No abnormalities were observed in the control group. All validity criteria were considered to be met. The 96h median LC50 was 1.21 (C.I. 0.874 - 1.64) based on geometric mean measured concentrations.


Orders up to 750gm are delivered 2nd Class mail, orders over 750gm to 1990g delivered 1st class mail, orders over 2kg delivered next day by 4pm by courier excluding weekends and bank holidays.
Online orders over 100kg will be refunded and someone will contact you.
We have lots of these dotted around the house, my daughter l ..


text:
En estadística, la razón de momios (RM), razón de oportunidades o razón de probabilidades —en inglés, odds ratio (OR)— es una medida  utilizada en estudios epidemiológicos transversales y de casos y controles, así como en los metaanálisis. En términos formales, se define como la posibilidad que una condición de salud o enfermedad se presente en un grupo de población frente al riesgo que ocurra en otro. En epidemiología, la comparación suele realizarse entre grupos humanos que presentan condiciones de vida similares, con la diferencia que uno se encuentra expuesto a un factor de riesgo (mi) mientras que el otro carece de esta característica (mo). Por lo tanto, la razón de momios o de posibilidades es una medida de tamaño de efecto.

Traducciones al español
Las traducciones de textos de epidemiología al español contienen una gran diversidad de traducciones del concepto odds ratio, que podría traducirse libremente como razón de oportunidades. Entre estas se encuentran los términos que hacen referencia a esta medida en su calidad de razón matemática: razón de probabilidades, razón relativa, razón de oportunidades, razón de posibilidades, razón de momios, razón de productos cruzados, razón de desigualdades, razón de disparidad, razón de exceso. Otros se refieren a la relatividad epidemiológica que se establece entre los términos de la razón, por ejemplo, oportunidad relativa (que mantiene la sigla OR utilizada en inglés),  disparidad, desigualdad relativa, relación impar. En ciertas obras se recoge el barbarismo razón de odds y se colige del concepto de riesgo que implementa la epidemiologia como riesgo de ventajas o riesgos cruzados''.

Definición de los odds

Los odds son la relación entre las cuentas de una categoría divida entre otra categoría de referencia. Por ejemplo, si tenemos una población de personas y hay 40 personas de las cuales 15 son mujeres, el odds de mujeres es la comparación de las cuentas de mujeres entre la cuenta de las personas en la otra categoría, es decir los hombres (40-15=25).

, o bien

Odds se relacionan con las proporciones de la siguiente manera:

Si se despeja a proporción en la ecuación anterior, se aprecia que

Si la proporción es muy pequeña, los odds son aproximadamente iguales a los mismos: Proporción≈Odds

Definición de los odds ratios

Para mostrar la definición de la razón de momios, es necesario tener al menos dos variables, cada una con al menos dos categorías. Tradicionalmente, tenemos una categoría de afectados por una Enfermedad (Enfermos y Sanos) y otra categoría denominada donde se suele valorar una Exposición (Presente vs Ausente) se puede hacer referencia a la tabla estándar de 2x2 (en el caso de que la exposición tenga dos categorías), también llamada tabla de contingencia.

Si vemos la definición de los odds arriba mencionada podemos decir que:

El odds ratio se define como los odds de los enfermos entre los expuestos dividido ente los odds de los enfermos entre los que tienen la exposición ausente, es decir:

Al reemplazar, obtenemos:

Al rearreglar los términos tenemos:

El odds ratio tiene valores que van desde 0 hasta el infinito positivo. Los valores de 1 indican que que la exposición no pone a riesgo de enfermar ni protege contra la enfermedad. Los valores mayores de 1 indican que la exposición pone a riesgo de enfermar, mientras que los valores inferiores a 1 indican que ésta protege contra la enfermedad.

El odds ratio ya sea cuando la exposición es muy rara en personas sanas y enfermas o bien la enfermedad es rara en el grupo expuesto y el no expuesto, es equivalente al riesgo relativo, debido a que como se aprecia arriba, los odds y las proporciones son muy similares cuando estos números son pequeños.

Los odds ratios son el resultado del modelaje de la regresión logística y su interpretación es la misma independientemente del diseño de estudio. Sin embargo, en el estudio de casos y controles, al realizar el modelaje, el intercepto carece de significado, a diferencia del estudio de cohortes y en el estudio de prevalencia, en los cuales el mismo representa a odds de enfermarse en todas las categorías de referencia del modelo.

Véase también
Riesgo relativo
Glosario de medicina basada en hechos

Referencias

Estudio epidemiológico
Medicina basada en hechos

redpajama_set_name: RedPajamaWikipedia