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Uterine Sarcoma
•Cancer that develops in the muscle or connective tissue of the uterus
•Symptoms include abnormal vaginal bleeding, pelvic and/or abdominal pain, bloating, a mass in the vagina or pelvis
•Treatment includes surgery, radiation therapy, chemotherapy, hormone therapy
•Involves medical oncology, gynecologic oncology program, sarcoma program
What is uterine sarcoma?
What are the symptoms of uterine sarcoma?
What are the risk factors for uterine sarcoma?
How is uterine sarcoma diagnosed?
How is uterine sarcoma treated?
What is the outlook for people with uterine sarcoma?
What is unique about Yale Medicine's approach to uterine sarcoma treatment?
Alessandro Santin
Obstetrics, Gynecology & Reproductive Sciences, Gynecologic Oncology
Masoud Azodi
Minimally Invasive Surgery, Gynecologic Oncology, Obstetrics, Gynecology & Reproductive Sciences
Farinaz Seifi
Minimally Invasive Gynecology, Gynecology, Obstetrics, Gynecology & Reproductive Sciences
Uterine sarcoma is a term that is used to describe different types of cancer that develop within the uterus.
Uterine sarcoma is a rare cancer, affecting only about 5,000 people in the United States each year. Uterine sarcoma is commonly diagnosed in women who are in their 40s through their 60s, although it is possible for it to occur in younger women. Although any woman may develop uterine sarcoma, the most common type, leiomyosarcoma, is twice as common in Black women than in white women.
How well a woman responds to treatment may depend on how advanced her uterine sarcoma is at the time of diagnosis. This form of cancer tends to grow and spread quickly. When it is caught early, treatment is more likely to be effective; about two out of three women who are diagnosed early with uterine sarcoma remain cancer-free after five years.
"Surgery remains the most effective treatment for the care of patients diagnosed with uterine sarcoma," says Alessandro Santin, MD, co-chief of the Section of Gynecologic Oncology and disease aligned research team leader for the Gynecologic Oncology Program at Smilow Cancer Hospital.
Uterine sarcoma refers to different cancers that occur in the muscle or connective tissue of the uterus. It is different than cancer of the uterine lining, or endometrium, which is called endometrial carcinoma.
There are three different types of uterine sarcoma:
Leiomyosarcoma, the most common type of uterine sarcoma, develops within the muscle walls of the uterus.
Endometrial stromal sarcoma, a less common type of uterine sarcoma, forms in the tissue that connects the uterine lining to the walls of the uterus.
Undifferentiated sarcomas of the uterus is the rarest of all three. This form of uterine sarcoma may begin in the uterine muscle or the uterine lining and tends to grow and spread quickly.
When women have uterine sarcoma, they may experience:
Abnormal vaginal bleeding between menstrual periods
Vaginal bleeding after menopause
A feeling of abdominal fullness
A palpable mass in the pelvis or vagina
Vaginal discharge that doesn't improve with medication
The following factors may raise a woman's risk of this cancer:
Having had radiation therapy to treat a previous cancer in the pelvic region
Taking the drug tamoxifen (to prevent or treat breast cancer) for five years or longer
Having a family history of hereditary leiomyomatosis and renal cell carcinoma syndrome, a rare inherited disorder
Being a survivor of retinoblastoma, a rare eye cancer that occurs in childhood
When doctors suspect uterine sarcoma, they perform a physical exam, ask patients about personal and family medical history, and order certain tests that may detect the cancer.
A doctor will ask the patient about the symptoms that she has experienced, including abnormal vaginal bleeding, discomfort or pain in pelvis or abdomen, and changes in bathroom habits. The doctor will also find out whether there has been a previous cancer diagnosis, and if so, what type of cancer it was and what treatment they received.
The doctor will also perform a pelvic exam and, if a palpable mass is felt, further testing may be required. When doctors suspect uterine sarcoma, they will order imaging tests, such as transvaginal ultrasound, CT scan, or MRI. If a mass is seen on the imaging tests, a tissue biopsy will be required to make a diagnosis.
Sometimes, uterine sarcoma is diagnosed after a woman has had a hysterectomy to treat painful fibroids. Additional surgery may be needed, depending on what was removed during the hysterectomy.
Some people may worry that fibroids are related to uterine sarcoma, but they are not. Fibroids are benign (noncancerous) masses that form in the muscle walls of the uterus, and are not—or rarely—linked to uterine sarcoma. Even if fibroids are undiagnosed and go untreated, they do not progress to uterine sarcoma.
The standard treatment for uterine sarcoma is hysterectomy, plus surgical removal of neighboring parts of the reproductive tract. A woman with uterine sarcoma will have her uterus removed, along with both of her ovaries and both fallopian tubes.
Doctors may also remove local lymph nodes, which will be biopsied to determine if the cancer has spread beyond the uterus. They may also rinse the pelvic cavity with a saline solution (salt water) after surgery, which allows them to check for the presence of cancerous cells; this is another way to see if the cancer has spread outside of the uterus.
After surgery, if doctors believe that the cancer was completely contained within the uterus and did not spread to other tissue, no further treatment may be needed. In other instances, patients may need chemotherapy, with or without radiation therapy, to eradicate any remaining cancer cells that may not have been removed during surgery. Women who have endometrial stromal sarcoma may also require hormone therapy after surgery.
About two thirds (66%) of women who are diagnosed with early-stage leiomyosarcoma survive 5 years or longer. The prognosis worsens if the cancer has spread beyond the uterus, declining to a 5-year survival rate of 13 to 34%. When uterine sarcoma spreads, it often metastasizes to the lungs or the abdomen.
"With the goal to personalize cancer treatment modalities for uterine sarcoma patients, Yale researchers have recently reported the most comprehensive genetic analysis of uterine leiomyosarcoma," says Dr. Santin. "This study provided the first preclinical evidence that a specific mutation profile identified through genetic sequencing may be predictive of drug response to targeted drugs both in vitro as well as in vivo. Accordingly, patients diagnosed with leiomyosarcoma at Yale may have access to personalized treatment modalities."
Uterine cancer is an umbrella term for cancers that develop inside the uterus. Learn about symptoms and treatment.
Uterine Adenomyosis
A condition in which the lining of the uterus grows into the muscle walls of the uterus.
Fibroids (Uterine Myoma)
Uterine fibroids are benign (non-cancerous) growths that may cause pelvic pain, swelling, discomfort during sex, bleeding and other problems.
Endometrial Hyperplasia
A precancerous condition in which there is an irregular thickening of the uterine lining.
The EMPOWER Study: Endometriosis Diagnosis Using microRNA (EMPOWER)
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Dr. Yasushi Kambayashi is an associate professor in the Department of Computer and Information Engineering from the Nippon Institute of Technology. He worked at Mitsubishi Research Institute as a staff researcher before joining the Institute. His research interests include theory of computation, theory and practice of programming languages, and political science. He received his PhD in Engineering from the University of Toledo, his MS in Computer Science from the University of Washington, and his BA in Law from Keio University. He is a committee member of the Japan Information-Technology Engineers Examination, a Fellow of IARIA, a committee member and the industry research chair of IARIA International Multi-Conference on Computing in the Global Information Technology and IARIA International Conference on Advances in P2P Systems, a committee member of Asia Pacific Symposium on Intelligent and Evolutionary Systems, an editorial board member of International Journal on Advances in Internet Technology, a review committee member of Peer-to-Peer Networking and Applications, and a member of ACM, IEEE Computer Society, Tau Beta Pi, IPSJ, JSSST, IEICE System Society, IADIS, and Japan Flutist Association.


Perkins+Will is an interdisciplinary, research-based architecture and design firm established in 1935 and founded on the belief that design has the power to transform lives and enhance communities. Each of the firm's 24 offices focuses on local, regional, and global work in a variety of practice areas. With hundreds of award-winning projects annually, Perkins+Will is ranked among the top global design firms. The firm's 1,600 professionals are thought leaders developing 21st century solutions to inspire the creation of spaces in which clients and their communities work, heal, live, and learn.
Perkins+Will is recognized as one of the industry's preeminent sustainable design firms due to its innovative research, design tools, and expertise, and was ranked Best Large Architecture Firm in USGBC's 2014 Best in Building Awards. Social responsibility is also a fundamental aspect of Perkins+Will's culture, and every year the company donates 1% of its design services to pro bono initiatives.


This year I'm approaching my 15th year with Eat'n Park Hospitality Group. Through the years, I've been involved in some really exciting projects and events, and this year is no different! I was recently approached by Community Kitchen Pittsburgh to volunteer for Project Lunch Tray, a cooking competition encouraging and inspiring kids to think outside the typical lunch box food and advocate for better school food. The competition paired eight teams from Pittsburgh Public Schools with various chefs across the city to create delicious, healthy, kid-friendly school lunch recipes.
As a volunteer, I was a mentor to four 7th and 8th graders from Arsenal Middle School: Thomas (8th grade), Catarin (7th grade), Karen (7th grade) and Karina (8th grade).
We started Project Lunch Tray by meeting at Arsenal Middle School to discuss what recipes we wanted to use in the competition. I brought 12 recipe ideas, but none of them were selected because each student had a different outlook on what they liked and what they wanted to see being offered. These young chefs had a vision of their own! Ultimately, we decided on a beef quesadilla and butternut squash quesadilla for our main courses and black beans and rice and quinoa with pumpkin and black beans for our sides.
Next up was a practice cooking competition at the Pittsburgh Public Market in the strip district. Each team prepared their dishes and gave out samples to customers.
The final competition was held during the Farm to Table conference where a panel of judges, as well as conference attendees, voted on each dish. Though the official winner was Propel Braddock Hills, I think that every participant came out ahead. In fact, my team is starting a cooking club at their school! I can't wait to see them use the skills they learned for many years to come.


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Q: Change (ubuntu/kdeneon) system QT PATH im crazy trying to changing the system qt path.
because i install qtcreator and all developer libs with the qtcreator install from official site in /opt/Qt.
the problem is that the system is using the default ubuntu qt ubication, so for example if i work with qtcreator not problem but if work with kdevelop its using the system qt headers and no found a lot of things, al whant to make  kdevelop and system use /opt/Qt
i already try changing the default.conf of qtchooser but not work.
who i can make my kde neon distro use my /opt/Qt libs and headers
thanks!

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Home Science And Technology Scientists discover dozens of new species in Galapagos depths
Scientists discover dozens of new species in Galapagos depths
Deep-sea experts discover fragile corals and sponges, as well as new species of crustacean.
An international team of marine scientists has discovered 30 new species of invertebrates in deep water surrounding the Galapagos, the Ecuadoran archipelago's national park authorities announced on Monday.
The deep-sea experts discovered fragile coral and sponges including 10 bamboo corals, four octocorals, one brittle star and 11 sponges – as well as four new species of crustacean known as squat-lobsters – the Galapagos National Park (GNP) said in a statement.
"These discoveries include the first giant solitary soft coral known for the Tropical Eastern Pacific, a new genus of glass sponge that can grow in colonies of over one meter in width and, colorful sea fans that host a myriad of associated species," the archipelago's Charles Darwin Foundation (CDF) said in a separate statement.
Scientists from the CDF, in collaboration with the National Park Directorate and the Ocean Exploration Trust, probed deep-sea ecosystems at depths of up to 3,400 metres (11,154ft) using state-of-the-art Remote Operated Vehicles (ROVs).
The two ROVs, Argus and Hercules, were operated from the 64-metre (209ft) exploration vessel Nautilus, which carried out the deep-sea probe in 2015.
"The deep sea remains as Earth's last frontier, and this study provides a sneak-peek into the least known communities of the Galapagos Islands," said CDF marine scientist Pelayo Salinas de Leon, who led the study and announced its findings.
Deep-sea exploration
The expedition explored, for the first time, three steep-sided underwater mountains, or seamounts, located near the islands of Darwin and Wolf in the archipelago's north. The area is home to the world's largest shark population.
"These pristine seamounts are within the Galapagos Marine Reserve and are protected from destructive human practices, such as fishing with bottom trawls or deep-sea mining, that are known to have catastrophic impacts upon fragile communities. Now, it is our responsibility to make sure they remain pristine for the generations to come," Salinas de Leon said.
"The many discoveries made on this expedition showcase the importance of deep-sea exploration to developing an understanding of our oceans," said Nicole Raineault, chief scientist of the Ocean Exploration Trust.
"Since we never know what we're going to find, we utilise land-based scientists who watch the ROV dives from home and communicate directly with the shipboard team in real-time, to help determine what is truly new and worthy of further investigation or sampling.
"Scientists studying the resulting video, data, and specimens make an astonishing number of discoveries, reminding us how little we know about the deep sea," said Raineault.
The Galapagos archipelago, located 1,000km (620 miles) west of Ecuador, is a fragile ecosystem that harbours the largest number of different animal species on the planet.
The news came after Ecuador raised concerns about the presence of a massive Chinese fishing fleeting near the protected waters surrounding the islands.
In recent weeks, Ecuador's navy conducted a patrol mission that included a flyover of the region where the vessels are fishing, as well as reconnaissance by military patrol ships.
A total of 340 ships were reportedly spotted in the area, the navy said, compared with some 260 reported last month.
Ecuador's navy commander, Rear Admiral Darwin Jarrin, said the navy had approached Colombia and Peru to share information and seek a regional response to the vessels, most of which can hold up to 1,000 tonnes of catch.
Ecuador and China have begun negotiations about the fishing fleet, according to reports.
Yolanda Kakabadse, Ecuador's former minister of the environment, told Public Radio International that the Galapagos should be "the last place on Earth to be affected by irresponsible actions of any sort".
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Reigning ABB FIA Formula E champion Jean-Eric Vergne says he has changed his approach to races from his title-winning campaign for the 2018/19 season.
Techeetah's Vergne secured four race victories during the 2017/18 campaign, scoring three of those from pole position.
In both Santiago and Punta del Este, Vergne's wins were achieved after managing to successfully defend the lead for several laps against teammate Andre Lotterer and Lucas di Grassi respectively.
On both occasions, Vergne's qualifying pace eclipsed his speed in the races.
But at last month's 2018/19 season-opener in Ad Diriyah, Vergne progressed up the order after qualifying fifth and had climbed into the lead of the race by mid-distance, although a drive-through penalty handed the race win to BMW's Antonio Felix da Costa.
Vergne recovered from his penalty to claim second, however, finishing only 0.4 seconds behind da Costa at the flag after overtaking five cars during the 45-minute race.
"Last year in the races that I won I didn't think I was really quick, it was more a question of how to defend," said Vergne.
"This year I really tried to improve myself and just be a quicker driver in the race so I think I was probably more on it than I was last season and that's where I will keep it this season."
Techeetah was narrowly beaten to the teams' title in the previous campaign after Audi's mid-season resurgence helped propel it to the championship.
But with Vergne's second place-finish in Ad Diriyah and Andre Lotterer - who was also handed a drivethrough penalty during the race - finishing fourth, the works DS outfit leads the teams' championship after the opening round of the 2018/19 season.


There are 2 bsn schools in Brockton, Massachusetts. The largest bsn school in Brockton, by student population, is Massasoit Community College, which has 7,941 students. The school's website has a Google Page Rank of 5. The school appears to maintain its site on a regular basis, as is indicated by the fact that there are not many broken links just one click away from the homepage.
Both bsn schools in Brockton have Facebook pages. Massasoit Community College's page has 1,412 "likes". Signature Healthcare Brockton Hospital School of Nursing's page has 273 "likes".
The only bsn school in Brockton with a YouTube channel is Massasoit Community College. Its YouTube channel has 0 subscribers.
Both bsn schools in Brockton have been bookmarked on Delicious. Massasoit Community College has been bookmarked 15 times. Signature Healthcare Brockton Hospital School of Nursing has been bookmarked 1 times.
The Brockton bsn school website that receives the greatest number of unique visitors belongs to Signature Healthcare Brockton Hospital School of Nursing. This is indicated by the fact that Signature Healthcare Brockton Hospital School of Nursing's site has a Compete Rank of 190,397, the highest Compete Rank of bsn school websites in Brockton.
And the Brockton bsn school website that is considered the most authoritative by SEOMoz belongs to Massasoit Community College. It has a SEOMoz Page Authority rank of 52.5.


This day-trip moves along the rocky coastline of West Antiparos. High cliffs and slabs diving in the sea, geometric features, big overhanging rocks and a variety of different colors compose the scenery we paddle through.
We witness the results of recent geological processes of volcanic origin. Beaches are not common in this area so we choose the ones available for our first break. Our main lunch break is taken at the sheltered fjord like bay of Monastiria just after the impressive high 'cornered' rockface.


Carefully follow the printed information given with the preparation.
Mix the contents of the sachet into water before taking.
Common side-effects include feeling sick and tummy (abdominal) discomfort or pain.
Macrogols belong to a group of medicines known as osmotic laxatives. They are substances which are used medically to relieve constipation or to clear the bowel before some clinical procedures. They are sometimes called polyethylene glycols. Macrogols are identified by a number which represents their molecular weight so, for example, the macrogol used to relieve constipation is called macrogol '3350'.
Constipation is a common problem which can be caused by a number of things. Not eating enough fibre or not drinking enough fluid can cause constipation. Some conditions (such as pregnancy) can cause constipation, as can a lack of exercise or movement (such as being ill in bed) and some medicines. Macrogols relieve constipation by drawing water into your bowel to soften your stools, making them easier to pass.
Bowel cleansing solutions also contain macrogol '3350' although they are not treatments for constipation. They are used to ensure that the bowel is free of solid contents before a bowel examination or surgical procedure.
If you have any bowel problems other than constipation, such as Crohn's disease, ulcerative colitis or toxic megacolon.
If the treatment is intended for a child. This is because laxatives should only be given to children on the advice of a doctor or healthcare professional.
Before starting the treatment, read the manufacturer's printed information leaflet from inside the pack. It will tell you how to prepare your dose and how long the solution can be kept for after preparation. Once mixed with water, the solution should be kept in the fridge. Do not use any solution remaining after the time recommended in the manufacturer's instructions.
Your doctor will tell you how many sachets to take for each dose. A daily dose can range from 1-2 sachets daily, up to a maximum of 8 sachets daily. Unless the directions say otherwise, stir the contents of each sachet into half a glass of water (100-125 ml) before taking.
You will be given written instructions from the clinic that will tell you how many sachets to make up into a solution, and when you should start to drink it. It is important that you follow the directions carefully.
You will also be given written instructions about what food or drink you can, or cannot, have until after the procedure is completed. Typically, the advice is to not eat any solid food from about two hours before you start drinking the solution. Again, it is important that you carefully follow the directions you are given.
The treatment can interfere with the absorption of medicines taken at the same time. If you take medication regularly, please ask your doctor about when to take your other medicines.
A healthy diet containing fibre (wholegrain breads and cereals, bran, fruit and green leafy vegetables) with several glasses of water each day and daily exercise are important in maintaining healthy bowel function. For people who have problems with constipation, food such as pastries, puddings, sugar, sweets, cheese and cake can make matters worse and are best avoided.
The preparation will start to work after an hour or two, so stay near to a toilet while you are taking the solution.
If you have any questions about the treatment, contact the hospital department where you are receiving the treatment for further advice.
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with macrogol '3350'. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Manufacturer's PIL, Movicol 13.8 g Sachet; Norgine Ltd, The electronic Medicines Compendium. Dated January 2017.


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'Gun and a Hotel Bible,' 'Love and Monsters,' 'Yellow Rose,' Kick Off 2021 on Home Entertainment
Blu-Ray / DVD ReviewsNews Angela Dawson|January 4, 2021
GUN AND A HOTEL BIBLE. (Key Artwork). ©Freestyle Digital Media.
By ANGELA DAWSON
Front Row Features
Gun and a Hotel Bible
Freestyle Digital Media will release "Gun and a Hotel Bible" on Digital Tuesday Jan. 5.
Based on an award-winning play, "Gun and a Hotel Bible" tells the story of Pete (Bradley Gosnell), a desperate man on the verge of a violent act and his encounter with Gideon (Daniel Floren), a personified hotel bible. As Pete and Gideon spar over ideas about morality, the Bible and God, they are forced to deal with their inadequacies. With the clock ticking, can Gideon sway Pete from pulling the trigger?
Co-directors Raja Gosnell ("Home Alone," "Mrs. Doubtfire") and Alicia Joy LeBlanc ("The Convergence: Mission") elicit sharply-honed performances by stars Bradley Gosnell ("The Smurfs") and Daniel Floren ("The Influencers").
"Gun and a Hotel Bible" will be available on iTunes, Amazon, Google Play, DirecTV, On Demand, YouTube Movies, Vudu, Xbox and FandangoNOW.
Love and Monsters
"Love and Monsters" arrives on 4K Ultra HD, Blu-ray and DVD Tuesday Jan. 5, from Paramount Home Entertainment.
Seven years after the Monsterpocalypse, Joel Dawson (Dylan O'Brien), along with the rest of humanity, has been living underground ever since giant creatures took control of the land. After reconnecting over radio with his high school girlfriend Aimee (Jessica Henwick), who is now 80 miles away at a coastal colony, Joel begins to fall for her again. As Joel realizes that there's nothing left for him underground, he decides to venture out to Aimee, despite all the dangerous monsters that stand in his way. The fun-filled and action-packed adventure also stars Dan Ewing, Michael Rooker and Ariana Greenblatt. The film is directed by Michael Matthews from a screenplay by Brian Duffield and Matthew Robinson.
The two-disc Blu-ray set includes deleted scenes, a featurette called "Bottom of the Food Chain: The Cast of 'Love and Monsters,'" and the featurette "It's a Monster's World: Creating a Post-Apocalyptic Landscape." It also is available now on Digital.
Three Films by Luis Buñuel
A three-film collection of works by Luis Buñuel arrive on Blu-ray, from Criterion Collection.
More than four decades after he took a razorblade to an eyeball and shocked the world with "Un chien andalou," the arch-iconoclast capped his astonishing career with three final provocations— "The Discreet Charm of the Bourgeoisie," "The Phantom of Liberty" and "That Obscure Object of Desire"—in which his renegade, free-associating surrealism reached its audacious, self-detonating endgame.
Working with such key collaborators as screenwriter Jean-Claude Carrière and his own frequent onscreen alter ego Fernando Rey, Buñuel laced his scathing attacks on religion, class pretension and moral hypocrisy with savage violence to create a trio of subversive, brutally funny masterpieces that explore the absurd randomness of existence. Among the director's most radical works as well as some of his greatest international triumphs, these films cemented his legacy as cinema's most incendiary revolutionary.
"The Discreet Charm of the Bourgeoisie" is a deliciously satiric masterpiece in which an upper-class sextet sits down to a dinner that is continually delayed. Their attempts to eat are thwarted by vaudevillian events both actual and imagined, including terrorist attacks, military maneuvers and ghostly apparitions. Stringing together a discontinuous, digressive series of absurdist set pieces, Buñuel and his screenwriting partner Carrière send a cast of European-film greats—including Rey, Stéphane Audran, Delphine Seyrig, and Jean-Pierre Cassel—through a maze of desire deferred, frustrated and interrupted. The Oscar-winning pinnacle of Buñuel's late-career ascent as a feted maestro of the international art house, the 1972 film also is one of his most gleefully radical assaults on the values of the ruling class.
In 1974's "The Phantom of Liberty," the inherent absurdity of human social rituals reaches its taboo-annihilating extreme in what may be Buñuel's most morally subversive and formally audacious work. Zigzagging across time and space, from the Napoleonic era to the present day, the film unfolds as a picaresque—its main character traveling between tableaux in a series of Dadaist non-sequiturs. Unbound by the laws of narrative logic, Buñuel lets his surrealist's id run riot in an exuberant revolt against bourgeois rationality that seems telegraphed directly from his unconscious to the screen.
In his final film, 1977's "That Obscure Object of Desire," Buñuel brings full circle the director's lifelong preoccupation with the darker side of desire. Rey plays Mathieu, an urbane widower, tortured by his lust for the elusive Conchita. With subversive flair, Buñuel uses two different actors in the latter role—Carole Bouquet, a sophisticated French beauty, and Ángela Molina, a Spanish coquette. Drawn from the surrealist favorite Pierre Louÿs's classic erotic novel "La femme et le pantin" ("The Woman and the Puppet," 1898), "That Obscure Object of Desire" is a dizzying game of sexual politics punctuated by a terror that harks back to Buñuel's avant-garde beginnings.
The three-disc Blu-ray box set is loaded with bonus features and will be available for a suggested retail price (SRP) of $99.95.
Arriving on Blu-ray, DVD and On Demand Tuesday Jan. 5 is Magnolia Home Entertainment's the thriller "12 Hour Shift," available from its Magnet label.
It's 1999 and over the course of one night at an Arkansas hospital, a drug-addicted nurse (Angela Bettis, "Carrie"), her scheming cousin (Chloe Farnworth, "Departure"), an injured convict (David Arquette, "Scream"), and a group of black market organ-trading criminals get caught up in a heist gone wrong.
"12 Hour Shift" will be available on Blu-ray for $29.98 (SRP) and on DVD for $26.98 (SRP).
The acclaimed indie drama "Yellow Rose" arrives on Blu-ray Tuesday Jan. 5, from Sony Pictures Home Entertainment.
A Filipina teen from a small Texas town fights to pursue her dreams as a country music performer while having to decide between staying with her family or leaving the only home she has ever known.
The music-filled drama, directed by Diane Paragas, stars Grammy-winner and two-time Tony nominee Eva Noblezada (Broadway's "Hadestown" and "Miss Saigon") in her feature film debut, award-winning country music artist Dale Watson, Princess Punzalan (Mula sa puso) and Tony winner and Grammy-nominee Lea Salonga ("Mulan," "Aladdin").
"Yellow Rose" also is available now On Demand and on Digital.
Tags:12 Hour Shift, Bradley Gosnell, Daniel Floren, David Arquette, Eva Noblezada, Gun and a Hotel Bible, lea salonga, Love and Monsters, Luis Buñuel, Three Films by Luis Bunuel, Yellow Rose
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Angela Dawson is the editor and co-owner of frontrowfeatures.com. An award-winning journalist, she has covered Hollywood since 2000. Her interviews with actors, directors, writers, authors and musicians have run in numerous outlets. She is the author of the novel "Generations: A Greek Family Odyssey" available on Amazon.com.
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'Dog Days,' 'Picnic at Hanging Rock,' 'Jack Irish,' More on Home Entertainment
Blu-Ray / DVD ReviewsNews Angela Dawson|November 25, 2018
Angela Dawson is the editor and co-owner of frontrowfeatures.com. An award-winning journalist, she has covered Hollywood since 2000. Her interviews with actors, directors, writers, authors and musicians have run in numerous outlets. She is the author of the novel "Generations: A Greek Family Odyssey" available on Amazon.com. Read Full
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I had planned to write about my first ever hack-a-thon last weekend, but decided to give a quick shout out to Grace Hopper on the 107th anniversary of her birth today.
Little did I know almost(gulp a quarter of a century ago), the impact she would have on my life.
I took a beginning COBOL class at the Community College of Aurora in 1990. I lucked into an entry-level programmer job at American Express as I was fortunate enough to have a shift supervisor who recommended me to the Application development manager. Much to my delight, I was offered a position on this team. It was a dream come true for me. I couldn't believe I was getting paid to do something I loved.
There was a time in my life where I couldn't wait for Monday's to come so I could go to work.
I worked for the same company for over 20 years. In 1993 the division that I worked for was sold to First Data Corporation. 13 years later, my department was absorbed into Western Union.
I was lucky to be able to form close relationships with my development teams as I moved from an entry level programmer to a team lead and eventually moved into a management role.
I raised my family and my wife and I were able to provide a college education for our children and many opportunities to travel and create wonderful family memories.
In 2010, the company that I worked at for 20+ years made the decision to eliminate our jobs and send the work overseas.
I find myself now looking to get back into programming. I am attending a web immersion bootcamp at MakerSquare in Austin, Texas.
Thanks Grace, for the blessings you have brought to my life.
Cobol to Ruby & Back © 2019. All Rights Reserved.


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Wrocław – basilica of St Elizabeth
plan of the St Elisabeth's basilica according to Architektura gotycka, 1995
view of the basilica in the 15th/16th century
view of the basilica in the 19th century
The first church in this place, initially called St. Lawrence, probably was formed in the early 13th century. In 1253 it was handed over by the crusaders as a monastery church. In 1252 the parish of St. Elisabeth was mentioned and in 1257 the church was consecrated under the name of Saint Elisabeth by bishop Thomas I.
The present three-nave basilica church founded by Boleslaw III was created in the style of brick gothic from the beginning of the 14th century. In the years 1309-1318 a nave span was erected, in 1340 the nave was finished, in 1384 chapel of the Blessed Virgin Mary, and in 1387 the chancel. The construction of the church tower began before 1339 and was completed in the 15th century.
The temple served as a parish church of the Wrocław patrician and expressed its ambitions, competing with the episcopal cathedral of St. John. Around the church there was a cemetery, surrounded by a crown of tiny houses of altar priests, which enhanced the impression of the size of the church. In 1525 the church of St. Elizabeth became the first Silesian church that took over the evangelicals. The takeover was supposed to take place as a result of the win of the Wrocław patrician and the royal treasurer Heinrich von Rybisch with the crusader Erhard Scultetus in the dice game. In 1529 a wooden tower helmet collapsed during the storm. The tower was rebuilt in the years 1531-1535 with a much smaller renaissance helmet of the form that exists to this day. In 1598, a roof of a monk and nun tiles was erected, forming a pattern of red-green chess. In 1649, a part of the roof collapsed. Once serious damage, the church suffered during the siege of the city by Napoleonic troops in 1806/1807, when the helmet was damaged on the tower and roof. In the years 1856-1857 the church was renovated, but during the work the outer wall of the southern nave collapsed, and with it, part of the vaults. After rebuilding and strengthening the church was re-consecrated in 1858.
At the end of the 19th century, most of the houses of the altar were demolished, leaving only four, and at the beginning of the twentieth century, one more demolished. There were only two houses connected by a gate and called Jaś and Malgosia. World War II the church survived without much damage, but unfortunately in 1960, 1975 and 1976 suffered damage caused by fires.
church plan according to J.Pilch, Leksykon zabytków architektury Dolnego Śląska
reconstruction of the church from the 16th century
The church is a large, three-nave, nine-span basilica composed of a nave separated by pseudotransept from the chancel. The chancel is ended trilateral. The building has extremely slender proportions, because the ratio of the width to the height of the central nave is one to three. At its south-west corner is from the south a five-storey tower with a porch in the ground floor, measuring more than 90 meters. Around the temple there is a row of medieval chapels and porches and there is a three-span sacristy from the north. Chapels are characterized by varied shapes and different solutions, some of them were even placed on the first floor. The front facade from the west is crowned with a triangular gable decorated with lancet blendes. The nave and the chancel are covered by steep gable roof, over the aisles and the chapels are the mono-pitched roofs. The facades of the church are pierced by pointed windows, in part of the presbytery and the side chapels and outbuildings, windows are filled with tracery. Portal from the south is pointed, profiled, covered with pinnacles and crowned with gable with frogs and flowers. A distinctive feature of the church was also the roof over the central nave, lined with tiles in green and red chessboard.
The interiors are mostly covered with extremely high rib vaults, with the exception of the stellar vault over the matroneum, the triple vault in the south porch and net vault in the north-west porch and the south-west chapel. The height of the main nave is 29.7 meters, the width of 10.2 meters and the length of 66 meters. The side wings are 5.5 meters wide and 13 meters high. Inside the church there are gothic stalls in the presbytery and a sacramentarium built in the years 1453-1455, which is a wonderful work of the gothic micro-architecture. Among the rather modest decoration are the stone bosses in the southern aisle with heraldic representations: the imperial eagle of Charles IV of Luxembourg, the lion with two tails being the coat of arms of the Bohemia and the eagle of the Duchy of Wrocław.
St Elisabeth's basilica
church tower and altarist houses, photo by J.Michalew
church tower, photo: J.Michalew
church from the south, photo by J. Michalew
southern chapel, photo: J.Michalew
presbytery, photo: J.Michalew
north-east chapel, photo: J.Michalew
northern aisle and side chapels, photo by J. Michalew
Smedchin chapel from the 14th century, photo: J.Michalew
church from the north-west side, photo: J.Michalew
portal in the tower, photo by J.Michalew
west facade, photo: J.Michalew
rosette on the west façade, photo: J.Michalew
interior of the central nave towards the presbytery, photo: J.Michalew
interior of the central nave towards the west, photo: J.Michalew
vault of the presbytery, photo: J.Michalew
vault of the central nave, photo by J.Michalew
interior of the central nave, photo by J.Michalew
interior of the side aisle, photo by J.Michalew
interior of the southern chapel, photo by J.Michalew
Architektura gotycka w Polsce, red. T. Mroczko i M. Arszyński, Warszawa 1995.
Pilch J, Leksykon zabytków architektury Dolnego Śląska, Warszawa 2005.
Walczak M., Kościoły gotyckie w Polsce, Kraków 2015.
Website zabytkowekoscioly.net, Wrocław – Stare Miasto, kościół św. Elżbiety.


Nice piece , Michael. Although I have never lived in New York, you told me some new things about it that filled in an important blank–that ot still looks much as it did 50 or more years ago. I don't live in that kind of place–LA is just a very new town still–I appreciate that same thing when I get an opportunity to see it. Thanks!
You are currently reading Roads Taken, Roads Imagined at Some Portraits and Notes on What I Heard.


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Responsible AI Dashboard
Responsible AI Toolbox
Notebook Tutorials
Responsible AI Toolbox Github
Responsible AI Dashboard Model Debugging
Assessing and debugging machine learning models is critical for Responsible AI. It helps determine how and why AI systems behave the way they do. Data scientists can then use this knowledge to improve model performance. Conceptually, model debugging consists of three stages:
Identify, to understand and recognize model errors by addressing the following questions:
What kinds of errors does my model have?
In what areas are errors most prevalent?
Diagnose, to explore the reasons behind the identified errors by addressing:
What are the causes of these errors?
Where should I focus my resources to improve my model?
Mitigate, to use the identification and diagnosis insights from previous stages to take targeted mitigation steps and address questions such as:
How can I improve my model?
What social or technical solutions exist for these issues?
Responsible AI Dashboard Decision Making
Decision-making is one of the biggest promises of machine learning. The Responsible AI dashboard helps you inform your model-driven and data-driven business decisions.
Data-driven insights to further understand heterogeneous treatment effects on an outcome, using historic data only. For example, "how would a medicine impact a patient's blood pressure?".
Model-driven insights, to answer end-users' questions such as "what can I do to get a different outcome from your AI next time?" to inform their actions.
Responsible AI Dashboard Components
The different components of the Responsible AI Dashboard are designed such that they can easily communicate with each other. You can interactively pass cohorts and insights from one component to another for deep-dive investigations, without having to manually save and reload results in different dashboards.
Model Statistics
A high-level view of model prediction distribution is often a useful starting point when investigating its performance. Analysis along a variety of metrics can help characterize errors more specifically, such as to distinguish between false positives and negatives in binary classification. This nuance builds intuition for next steps in model debugging.
The Model Statistics dashboard component aggregates a variety of metrics for both numerical and categorical labels, and provides box plots and bar chart visualizations. The x-axis enables the display of different kinds of statistics and metrics. The y-axis enables comparative views along different cohorts and dataset features.
Use Model Statistics when you need to…
Understand how your model performance varies across different metrics and/or subgroups in your data.
Decide what steps to take first on your model debugging journey.
Machine learning models work by making predictions based on decisions from past examples. As a result, their performance in real-world scenarios are heavily influenced by the data they are trained on. For example, when feature distribution in a dataset is skewed, this can cause a model to incorrectly predict datapoints belonging to an underrepresented group or to be optimized along an inappropriate metric.
The Data Explorer dashboard component helps to visualize datasets based on predicted and actual outcomes, error groups, and specific features. This helps to identify issues of over- and underrepresentation and to see how data is generally clustered in the dataset. Data visualizations consist of aggregate plots or individual datapoints.
Use Data Explorer when you need to …
Understand the distribution of your dataset across different cohorts and feature groups.
Determine whether your findings related to fairness, error analysis and causality (derived from other dashboard components) are a result of your dataset's distribution
Decide in which areas to collect additional data to mitigate errors arising from representation issues, label noise, feature noise, label bias, etc.
Interpretability
When ML models are used in ways that impact people's lives, it is critically important to understand what influences the behavior of models. Interpretability helps answer questions in scenarios such as model debugging (Why did my model make this mistake? How can I improve my model?), human-AI collaboration (How can I understand and trust the model's decisions?), and regulatory compliance (Does my model satisfy legal requirements?).
The interpretability component contributes to the "diagnose" stage of the model lifecycle workflow by generating human-understandable descriptions of the predictions of a Machine Learning model. It provides multiple views into a model's behavior: global explanations (e.g., what features affect the overall behavior of a loan allocation model) and local explanations (e.g., why a customer's loan application was approved or rejected). One can also observe model explanations for a selected cohort as a subgroup of data points. This is valuable when, for example, assessing fairness in model predictions for individuals in a particular demographic group. The local explanation tab of this component also represents a full data visualizations which is great for general eyeballing the data and looking at differences between correct and incorrect predictions of each cohort.
The capabilities of this component are founded by InterpretML capabilities on generating model explanations.
Use Interpretability when you need to…
Determine how trustworthy your AI system's predictions are by understanding what features are most important for the predictions.
Approach the debugging of your model by understanding it first and identifying if the model is using healthy features or merely spurious correlations.
Uncover potential sources of unfairness by understanding whether the model is predicting based on sensitive features or features highly correlated with them.
Build end user trust in your model's decisions by generating local explanations to illustrate their outcomes.
Complete a regulatory audit of an AI system to validate models and monitor the impact of model decisions on humans.
Documentation: interpretml/interpret-community: The Interpret Community extends Interpret repository with additional interpretability techniques and utility functions to handle real-world datasets and workflows. (github.com)
Error Analysis
One of the most apparent challenges with current model debugging practices is using aggregate metrics to score models on a benchmark. Model accuracy may not be uniform across subgroups of data, and there might exist input cohorts for which the model fails more often. The direct consequences of these failures are a lack of reliability and safety, unfairness, and a loss of trust in machine learning altogether.
The Error Analysis component provides machine learning practitioners with a deeper understanding of model failure distribution and assists them with quickly identifying erroneous cohorts of data. It contributes to the "identify" stage of the model lifecycle workflow through a decision tree that reveals cohorts with high error rates and a heatmap that visualizes how a few input features impact the error rate across cohorts. Discrepancies in error might occur when the system underperforms for specific demographic groups or infrequently observed input cohorts in the training data.The capabilities of this component are founded by Error Analysis capabilities on generating model error profiles.
Use Error Analysis when you need to…
Gain a deep understanding of how model failures are distributed across a given dataset and across several input and feature dimensions.
Break down the aggregate performance metrics to automatically discover erroneous cohorts and take targeted mitigation steps.
Blog post: Responsible Machine Learning with Error Analysis (microsoft.com)
Towards Accountable AI: Hybrid Human-Machine Analyses for Characterizing System Failure. Besmira Nushi, Ece Kamar, Eric Horvitz; HCOMP 2018. PDF
Counterfactuals Analysis and What-If
What-if counterfactuals address the question of "what would the model predict if the action input is changed?, enable understanding and debugging a machine learning model in terms of how it reacts to input (feature) changes. Rather than approximating a machine learning model or ranking features by their predictive importance (which standard interpretability techniques do), counterfactual analysis "interrogates" a model to determine what changes to a particular datapoint would flip the model decision. Such an analysis helps in disentangling the impact of different correlated features in isolation or for acquiring a more nuanced understanding on how much of a feature change is needed to see a model decision flip.
The Counterfactual Analysis and what-if component consists of two functionalities:
Generating a set of examples with minimal changes to a given point such that they change the model's prediction (i.e. showing the closest datapoints with opposite model precisions)
Enabling users to generate their own what-if perturbations to understand how the model reacts to features' changes.
The capabilities of this component are founded by DiCE package, which implements counterfactual explanations that provide this information by showing feature-perturbed versions of the same datapoint who would have received a different model prediction (e.g., Taylor would have received the loan if his/her income was higher by $10,000).
Use What-If Counterfactuals when you need to:
Examine fairness and reliability criteria as a decision evaluator.
Debug specific input instances in depth.
Provide solutions to end users and determining what they can do to get a desirable outcome from the model next time.
DiCE Documentation -> interpretml/DiCE: Generate Diverse Counterfactual Explanations for any machine learning model. (github.com)
Research Project -> DiCE: Diverse Counterfactual Explanations for Machine Learning Classifiers – Microsoft Research
Research Paper -> [1905.07697] Explaining Machine Learning Classifiers through Diverse Counterfactual Explanations (arxiv.org)
While machine learning models are particularly powerful in identifying patterns in data and making predictions, they offer little support for estimating how a real-world outcome changes in the presence of an intervention. Practitioners have become increasingly focused on using historic data to inform their future decisions and business interventions e.g., how would revenue be affected if a corporation pursues a new pricing strategy? Would a new medication improve a patient's condition, all else equal?
The Causal Inference component addresses these questions by estimating the effect of a feature on an outcome of interest on average, across a population or a cohort and on an individual level. It also helps to construct promising interventions by simulating different feature responses to various interventions and creating rules to determine which population cohorts would benefit from a particular intervention. Collectively, these functionalities allow decision makers to apply new policies and effect real-world change.
The capabilities of this component are founded by EconML package, which estimates heterogeneous treatment effects from observational data via machine learning.
Use Causal Inference when you need to…
Identify the features that have the most direct effect on your outcome of interest
Decide what overall treatment policy to take to maximize real-world impact on an outcome of interest
Understand how individuals with certain feature values would respond to a particular treatment policy
Blog post: Be Careful When Interpreting Predictive Models in Search of Causal Insights
EconML: https://www.microsoft.com/en-us/research/project/econml/
EconML Documentation: https://econml.azurewebsites.net/
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In this 237th episode, AC and CJ plow through a ton of news in the cloud space related to Microsoft, Azure, Office 365 and AWS. They spent a bit more time this week on picks… including an awesome listener submission!
Reddit: SpaceX: Elon: This rocket was meant to test very high retrothrust landing in water so it didn't hurt the droneship, but amazingly it has survived. We will try to tow it back to shore.


The Conference reaffirmed its respect for the sovereignty, territorial integrity, political independence and unity of Somalia. It agreed that for genuine peace to take hold in Somalia, Somali people should seek dialogue, reconciliation and political cooperation including in establishing inclusive, accountable and legitimate governance. The Conference is grateful for the wide-scale and strong Somali participation, including women, in this Conference, and the powerful and meaningful messages they have pronounced.
The Conference noted that at this critical period in Somalia's history, the security, political, social and economic achievements of the past year have given Somalis and the international community a renewed hope for the future. Somalia has made considerable progress towards achieving stability, security and reconciliation: this opportunity should not be missed. The Conference emphasized that August 2012 is the beginning of a new phase of peace-building, in which all Somalis would contribute to peace and have their voices heard.
The Conference highlighted that primary responsibility for establishing a political solution in the country lies with Somalis. The role of the international community is to support Somalis to provide leadership and ownership in rebuilding a functioning state and local governments that can provide security, ensure the rule of law and respect for human rights, provide basic social services and create an enabling environment that allows for economic opportunity for all its citizens.
It reconfirmed the importance of the London Conference that constituted a milestone in gathering the international momentum on Somalia, and pledged to ensure a continued coherent and cooperative international approach.
The Conference reiterated that the transitional period will come to an end in August 2012 in accordance with the Kampala Accord, the Roadmap, the Garowe I and II Principles, the Galkayo Agreement and re-affirmed commitment made by the Signatories to the Roadmap through the Addis Ababa Communique. It called for the timely implementation of these decisions and delivery of pledged funds. The Conference commended the convening of the Traditional Elders in Mogadishu who are carrying out their task of selecting the members of the Constituent Assembly and the new Parliament. It welcomed their efforts to ensure that women meaningfully participate in the process and constitute 30% of the Constituent Assembly and the new Parliament and the role of women is enshrined in the constitution.
The Conference welcomed the intention that the Constituent Assembly adopts the provisional constitution of Somalia. It highlighted the importance of Somali ownership of the constitution through a public debate and future adoption through a referendum. The Conference also commended the ongoing public consultations and civic education process in order to allow the Somali people to have their voices heard and participate in the political process. The Conference urged the Roadmap signatories to expand this effort to include newly recovered areas.
The Conference expressed the firm expectation that the selection process of the leaner and more representative Federal Parliament is completed in a fair and transparent way without any hindrance and that the elections for the positions of Speaker (and Deputies), and President by the new Parliament are carried out smoothly by 20 August 2012.
The Participants reiterated their firmness in not allowing internal and external actors or groups to disrupt the smooth implementation of the end of the Transition. In this context, they commended the joint AU-IGAD-UN letter of May 2012 to such potential actors in Somalia. They agreed to consider appropriate follow-up action against those judged to be blocking progress in the political process.
10. The Conference reiterated the crucial need for the international community to support dialogue that Somaliland and the TFG have agreed to pursue.
11. The Participants looked forward to the beginning of a new political dispensation, with a new Parliament and Government, and emphasized the importance of those institutions coming to fruition through a more representative, transparent and legitimate process.
12. In keeping with the London Communique, the Conference reiterated that respect for human rights must be at the heart of the peace process. It welcomed the Memorandum of Understanding signed between the Transitional Federal Government and the United Nations on 11 May 2012, and called on the Somali authorities to follow through with their commitment to uphold human rights and the rule of law, and put an end to the culture of violence and impunity, and bring about accountability. The Conference called for all parties to commit themselves to transitional justice mechanisms in the Post-Transition period.
13. The Conference emphasized that in the post-Transition period, the new political dispensation in Somalia must begin with a new program aimed at re-establishing of state and local institutions and administrative structures, based on and complementary to the current Roadmap including the newly recovered areas.
14. The Conference noted need to adjust international support to the political structures in Somalia and called on the UN to review the shape of its future engagement in Somalia.
15. The Conference agreed on the need to revitalize funding arrangements. The Conference took note of the proposal for the establishment of a new "Rebuilding and Restructuring Fund for the Somali Security Sector" initiated by Turkey to offer additional support to the Somali security forces.
16. The Conference recognized the need for the international community to continue to support the re-establishment of a professional, inclusive, disciplined and well-equipped security apparatus, including the Somali national army, police, navy, coastguard and intelligence agencies, as well as mechanisms to ensure civilian oversight of the security sector. The Conference emphasized the urgency to approve and implement the National Security and Stabilization Plan and the need to bring all Somali forces under a unified command. In this context, it recognized the significant contributions that the EU, including through the EU Training Mission, the US and Italy are providing in support of the Somali security sector institutions. The Conference encouraged broader support to these institutions.
17. The Conference commended the ongoing support of the international community for AMISOM, particularly by the United Nations, the European Union, IGAD member-states and the US and other bilateral partners. The Conference called on new donors to provide financial support to AMISOM troops including salaries, entitlements, reimbursement of contingent-owned equipment (COE), and enabling assets.
18. The Conference praised the efforts of the African Union through AMISOM and particularly those of Uganda and Burundi who have made troop contributions to AMISOM, and looking forward to the completion of troop deployments from Djibouti, Sierra Leone and Kenya. Today AMISOM, alongside its Somali Security Force allies is the main military instrument in ensuring security and stability in Somalia. We emphasized that the TFG and AMISOM have to be strongly supported by the international community at this critical juncture to meet objectives.
19. The Conference agreed that insecurity in Somalia, including sustained inter clan conflict, persistent violence, illegal charcoal trading, misappropriation of funds, piracy, kidnapping, terrorism and human rights abuses and violations, is exacerbated by the crisis emanating from the deficiency of the state structures and institutions in large parts of the country. It condemned all acts of violence against civilians, including journalists, and humanitarian workers in violation of international humanitarian law and human rights law.
20. The Conference reiterated its commitment to coordinate its efforts in support to the security and justice sectors through a re-invigorated Joint Security Committee and its technical working groups and looked forward to discussing proposals in this regard.
21. The Conference reiterated the need for effective rule of law institutions. The Conference stressed the importance of a broad consultative process in developing a plan to strengthen justice and correctional institutions and called for the establishment of a task force consisting of the TFG and international partners.
22. The Conference rejected all forms of terrorism, violations of human rights and violent extremism which endanger the lives of the Somali people, as well as regional and international peace. The Somali population has suffered a great deal at the hands of violent extremists and participants agreed to work together to help build capacity to confront the root causes of terrorism, tackle terrorism in the region, and disrupt their travel to and from Somalia. It agreed to work with the Global Counter-Terrorism Forum and other international and regional bodies to deliver this important work.
23. It condemned the use of child soldiers and sexual violence by the combatant sides. The Conference also deplored the recent attacks against journalists. Those who are responsible must be held to account. The Conference called on all Somalis to renounce unlawful acts of violence, to operate within a constitutional framework and to support the ongoing political process. Those who refuse to do so, and instead engage in or support violence and crime, should be dissuaded, isolated, or otherwise prevented from derailing the Roadmap and the process of Somali reconciliation and state-building. The Conference resolved to develop further a programme to support those who renounce violence.
24. The Conference reiterated that the problem of piracy off the coast of Somalia requires a comprehensive approach on land as well as at sea that addresses the root causes of the phenomenon and combines development, capacity-building, rule of law, deterrence and prosecution on the basis of UNSC Resolution 2020 (2011) and full compliance of international law. It called for the reinforcement of Somali-owned judicial capacities. The Conference looks forward to discussing the issue of piracy in depth and at length during the UAE's Second High Level Piracy Conference "A Regional Response to Maritime Piracy: Enhancing Public Private Partnership and strengthening global engagement to be held in Dubai on 27-28 June 2012 and the International Piracy Conference to be held in Perth, Australia on 15-17 July, 2012. The Conference further supports the ongoing work of the Contact Group on Piracy off the Coast of Somalia, including its forthcoming 12th Plenary Meeting to be held in New York on 25 July 2012.
25. The Conference recognized that the Somali leaders with the support of the international community face a huge challenge in ensuring a stable and secure environment in the recovered areas as soon as possible. A power vacuum must not be allowed to develop in those areas.
27. The Conference called upon the international community to consider further ways and means of stabilizing and securing emerging areas of stability and sustaining these through governance programs. The Stability Fund established at the London Conference shall serve this purpose and thus should be supported.
28. The Conference recognized the continued fragility of the humanitarian situation. With international support in the summer of 2011, Somalia was able to overcome the famine and avoid further exacerbation of the humanitarian crisis. However, more than 2.5 million Somalis remain in crisis and the risk of a further deterioration persists. The Conference called for immediate, unhindered access to all populations in need, respecting agreed humanitarian principles.
29. The Conference recognized the primary role of the Somali authorities as well as the important role of the international community in assisting Somalis in strengthening resilience. The Conference welcomed the Partnership Forum's efforts to build consensus on preventive and preemptive policies in this regard, and pledged to continue the dialogue.
30. The Conference underlined the importance of finding durable solutions for refugees and internally displaced persons (IDPs). It stressed in particular that protection of civilians in accordance with international humanitarian and refugee law must be maintained at all times by all parties.
31. The Conference recognized the need for a new phase in the approach to Somalia's economic recovery.
32. The Conference underscored its belief that without special and equal emphasis on the reconstruction area, work in other spheres would be incomplete. Starting to rebuild Somalia's infrastructure in Mogadishu and other areas will contribute to Somalis' confidence in their future and constitute an incentive and encouragement for all segments of Somalia to reconcile.
34. The Conference noted the importance of creating the right investment climate and agreed that offering conditional investment guarantees will provide a strong incentive for economic development with equity.
35. The Conference emphasized the importance of encouraging equitable growth to reduce poverty and deprivation in Somalia including through the promotion of inclusive business practices and service provision. Participants agreed on the need for capacity building in the public and private sectors. It was noted that institutional development was needed to ensure government can establish a socially responsible and business-friendly regulatory environment. They recognized the importance of diversification of energy sources, improvements in the quality and scope of the transport infrastructure in a way that supports economic development and investment in urban water supply, rural water supply, water resource management and water governance.
36. The Conference resolved to continue the discussion through further public-private dialogue, supported by the United Nations as well as the Istanbul International Centre for Private Sector in Development.
37. The Conference welcomed ongoing negotiations to establish a mutual accountability regime built around the proposed Joint Financial Management Board (JFMB). It urged the early conclusion of the negotiations establishing the JFMB and noted that the international community remains committed to helping Somalia better regulate its finances and development assistance.
38. The Conference welcomes the establishment of a multi-donor Trust Fund for post-Transition financing.
39. The Conference expected the ICG to be held in Rome on 2-3 July to take stock of the progress made here in Istanbul and give the final impetus to the very last part of the Transition.
40. The Conference commended the UN, the African Union, the IGAD, the EAC, the EU, the OIC and League of Arab States, and other bilateral partners for their relentless efforts in stabilizing Somalia. It welcomed the relocation of UNPOS and encouraged the UN to continue to relocate staff inside Somalia. Donors are encouraged to support this. The Conference also encouraged other organizations and countries to increase their presence in Somalia.


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Key Discovery Made in Genetic Make-Up of Heart Condition Linked to Sudden Cardiac Death
Submitted by SCAFoundation on Fri, 07/06/2018 - 12:00am
A new study published in Circulation, a peer-reviewed journal of the American Heart Association and led by a cardiologist at the Peter Munk Cardiac Centre at Toronto General Hospital has found evidence that only one of the 21 genes normally associated with Brugada Syndrome, a serious genetic heart condition associated with the risk of sudden arrhythmic death, is a definitive cause of the condition.
"The global impact of this important research is significant for scientists, medical professionals and patients who are genetically pre-disposed or who have been diagnosed with this potentially-fatal heart condition," says Dr. Barry Rubin, Medical Director, Peter Munk Cardiac Centre, University Health Network. "The evidence-based findings of our internationally-recognized, multi-disciplinary team of researchers could dramatically alter both the diagnostic and treatment pathway for patients with Brugada Syndrome as well as other genetic-based conditions."
The study's findings came as the result of evaulations conducted by the Clinical Genome Resource (ClinGen) expert panel led by Dr. Michael Gollob, cardiologist, Peter Munk Cardiac Centre and Chair, Peter Munk Centre of Excellence in Molecular Medicine. ClinGen is supported by the National Institutes of Health (NIH) in the United States.
"Our research examined the genetic evidence for 21 genes reported as single gene causes for Brugada Syndrome," says Dr. Gollob. "Remarkably, 20 of 21 genes were classified as disputed evidence, indicating that genetic evidence to support causation of this disease by these specific genes was lacking," he says.
Researchers found that only the SCN5A gene, first discovered 20 years ago for Brugada Syndrome, was deemed a definitive cause of the condition. The study also highlights the risks associated with the genetic testing of genes that lack sufficient evidence for disease causation.
"Clinically, evaluating genes that lack validity for disease causality creates a risk of misinterpreting the relevance of genetic changes in these genes and may lead to inappropriate diagnostic conclusions and treatment in patients," says Dr. Gollob. "Our conclusions from this study are surely not unique to Brugada Syndrome. Invalid or questionable gene-disease associations are likely common for many diseases across multiple medical disciplines," he says.
"This ClinGen report highlights the importance and value of ClinGen's efforts to standardize and improve the databases used by laboratories to guide testing decisions and the interpretation of test results," said Jonathan Berg, MD, PhD, FACMG whose group leads theClinGen Cardiovascular Genomics Clinical Domain Work Group under which this Expert Panel completed their work on determining which genes are actually associated with Brugada Syndrome.
Based on their findings, the authors recommend that an evidence based evaluation of reported gene-disease associations should be completed prior to the testing of genes in patient care.
Read journal article here.
SOURCE: Newswise


The noise floor approach gives Vorbis its characteristic analog noise-like failure mode when the bitrate is too low to encode the audio without perceptible loss.
A number of websites, including Wikipedia , use it. Vorbis has different uses for consumer products. Vorbis streams can be encapsulated in other media container formats besides Ogg.
Vorbis is most commonly used in conjunction with the Ogg container format  and it is therefore often referred to as Ogg Vorbis. Publish Creating your podcast with Podbean is a simple, intuitive process.
Comparison between mp3 and vorbis The first is an uncompressed wav file. Bo Kaspers Orkester. Because play is how we learn. Podbean gives you everything you need to create professional podcasts in minutes without any programming knowledge.
Check it out and send us your feedbacks to dev fictionpress.
Podbean is an easy and powerful way to start podcasting. Though Vorbis is technically superior addressing many of the limitations inherent to the MP3 design , MP3 has a far higher public profile. The reason that peeling programs degrade quality so severely is that the format does not specify the relative importance of signal data, and existing encoders do not order the data in order of importance, hence peelers cannot easily determine if data is important or not.
Vorbis is a continuation of audio compression development started in by Chris Montgomery. Users can access Gmail on the web and using third-party programs that synchronize email.
Vorbis metadata , called Vorbis comments , supports metadata tags similar to those implemented in the ID3 standard for MP3.
Vorbis is supported by several large digital audio player manufacturers such as Samsung , SanDisk , Rio , Neuros Technology , Cowon , and iriver. Just In All Stories: Below are links to several listening test results. A Guide for Libraries. We want everyone to be able to use Ogg Vorbis.
From Wikipedia, the free encyclopedia. No technology to learn. Jack Moffitt says, "We are changing the license in response to feedback from many parties. Org announces support for the WebM open media project".
Building games for the Windows Phone and other mobile devices. The Vorbis format has proven popular among supporters of free software.
We have just released v4. Let. Story Story Writer Forum Community. A Harry Potter Podcast Arts:At Poki, we let the world play.
Archived from the original on May 12, Check it out for your mobile reading needs. Sonos is the home sound system: a smart network of wireless speakers that fills your home with pure, immersive sound, room by room.
Via third-party multimedia framework. Problems playing this file?
They continued refining the source code until the Vorbis file format was frozen for 1. Bo Kaspers Orkester har under två decennier skapat ett skandinaviskt soundtrack med deras sofistikerade blandning av pop.
Most of the tuned versions of Vorbis attempt to fix the pre-echo problem and to increase the sound quality of lower quality settings -q-2 through -q4. The decompression algorithm reverses these stages. Tremor , a version of the Vorbis decoder which uses fixed-point arithmetic rather than floating point , was made available to the public on September 2, also under a BSD-style license.
Requires installation of LAV Filters. The underlying bug has been fixed and preventive measures have been added to prevent this from […]. 58K likes. Due to the ever-evolving nature of audio codecs, the results of many of these tests have become outdated.
Like the current version of ID3, users and encoding software are free to use whichever tags are appropriate for the content.
Many video game titles store in-game audio as Vorbis, including Amnesia: The size of the vector and the size of each string in bytes is limited to 2 32 -1 about 4. Similar statements apply to other devices capable of running Rockbox, as well. It is our mission to become the ultimate online playground for players and game developers alike. This vector is stored in the second header packet that begins a Vorbis bitstream.
For the Discworld character, see Religions of the Discworld. Gmail is a free, advertising-supported email service developed by Google. Views Read Edit View history. Some tuning suggestions created by the Vorbis user community especially the aoTuV beta 2 tunings have been incorporated into the 1.
A number of versions that make adjustments for specific platforms and include customized optimizations for given embedded microprocessors have been produced.


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Barry Clark-Ewers
Barry has a nose-to-tail wealth of experience in the non-fiction world, having held significant production/distribution roles at both Red Bull and Universal Pictures, he then Co-founded the production, finance and distribution outfit, Mr Wolf / Arts Alliance Ltd, which grew to become the world's leading event cinema company.
Titles included, 'Springsteen & I', One Direction's 'Where We Are', Arcade Fire's 'The Reflektor Tapes', Brett Morgen's 'Cobain: Montage of Heck' and Jonas Kaufmann: 'An Evening with Puccini' among others. Most recently Barry was a Producer on the Ronnie Wood documentary 'Somebody Up There Likes Me' and the BAFTA longlisted / five star reviewed feature doc 'Billie', a moving portrait of Billie Holiday that premiered at the 2019 Telluride Film Festival.
barry@brclg.com
Matt Harris is a seasoned Director of Photography having worked for over 30 years in all areas of creative image making from photography to graphic design, animation and filmmaking. Having started out as an underwater photographer / explorer in the Marshall Islands, Matt soon progressed to moving images working on branded and commercial content for some of the most prominent companies in the world such as Google, Paypal, Bloomberg, Qatar Airways and Aston Martin as well as DOP and directing for the BBC, Channel 4 and Channel 5 to name but a few.
Most recently Matt has written, directed and shot the cult action sports hit 'Rom Boys: 40 Years of Rad' with 1091 Pictures (which received 100% fresh on Rotten Tomatoes and won the Paris Surf and Skate Film Festival 2020) and directed and shot 'The Lancaster Bomber at 80' with David Jason for Big Little Fish TV and Channel 4.
matt@brclg.com


Second meeting was very important to Giants. For the past two seasons we have stolen the first game from Coopers only to be destroyed in the second match of the season. Coopers has been playing some good lacrosse and we were still getting our feet under ourselves. Today our offense played very well, with good movement and goals from nine different players including one from Thom O'Rourke. Good game Coopers and thanks for coming to our drink-up. Good luck the rest of the way.


To strengthen our whole school approach to our Core Values, we will be exploring a major theme (core value) over each half term. Every week, there will be a focus on a particular aspect of that theme. This is to help the children develop a deeper understanding of the core values of our school.
is directly linked to that week's core value.
Positively affect our self-esteem and self-confidence.
Provide a moral framework within which we live and learn.
Help us to be reflective which leads to development and improvement.
Develop mutual respect and acceptance of our cultural differences.
Help to develop quality relationships between staff, pupils and the community.
Enable everyone to be equal and have a voice.
Help to develop the ability to understand and express feelings.
Help us to reach our potential in every dimension of our being.
Introducing the Core Value of the half term through assemblies and story times.
Making the Core Value an implicit feature across the whole curriculum.
Having central displays showcasing the Core Value.
Recognising and celebrating behaviour that reflects our Core Values.
Encouraging children to take on appropriate responsibilities.
Recognising and learning from the hard work and success of others.
Recognising the contribution and impact of the actions of others.
All adults acting as role models.
Asking parents and the community for their support.
Looking at the positives rather than the negatives.
Finding time for yourself and showing that you are human.
Remembering to be and not just to do.
Living your values even when things get tough.
Ensuring all smiles are returned.


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Chelsea vs Manchester City Preview
For the last five years in England, blue has been the winning colour, with both Chelsea and Manchester City claiming two titles each in between Leicester City's unthinkable 2014/15 campaign. Now, with the two heavyweight giants squaring up this weekend, both in their blue corners, we could be in store for another epic showdown. Manchester City have shown no signs of slowing down in their pursuit of defending their league title, while Maurizio Sarri's Chelsea have somewhat forced their way into the conversation, jumping into third spot last weekend.
Saturday 8 December
To Win
Chelsea 3/1
Draw 29/10
Manchester City 17/20
Chelsea will be looking to make a statement of intent and convince their doubters that they are in this league to win it when they face a rampant Manchester City outfit. The Blues have done very little wrong this season and have climbed up into third spot after their derby win over Fulham.
But Sarri is not getting carried away, and still persists that there is one team above the rest in England – which is this weekend's opponents, Manchester City.
"For me they are stronger than us.
"We have to work very hard just to try to recover the gap, but at the moment the gap is still there.
"In the Premier League, there is a team above the others. This team is Manchester City," Sarri said.
A fair statement from the former Napoli boss, and one I tend to agree with. The Blues are still some way off of the top of the table – but getting back in the UEFA Champions League seems a much more realistic target.
Chelsea don't have an out-and-out goalscorer, like their top rivals in the league, but what the Blues do possess is an Eden Hazard. The Belgian wizard has been a marvel to watch at times this season and is on course to break his personal tally of 16 goals for the season – set back in 2016/17.
The City backline hasn't shown much signs of frailty, but Hazard will be hoping to turn the fortunes around and inspire his Chelsea side to victory this Saturday.
What could be Chelsea's downfall at the weekend is getting the position of N'Golo Kante and Jorginho wrong. It seems to be a debate we cannot ignore in recent weeks, with teams now knowing that everything comes through the Italian.
On the ball, Sarri's men look brilliant, but without it, a side of City's calibre could make them look ordinary. Kante has won two league titles and a FIFA World Cup in his natural position, but it seems Sarri has opted for a more technically gifted footballer in the defensive midfield role.
If Kante plays his natural position, City's attack could then look ordinary.
It's not very often that you see the visiting side as overwhelming favourites at Stamford Bridge, but that should give you an indication as to how far Pep Guardiola has taken this Manchester City team. The Citizens ran away with the title last season, and as frightening as it may seem, the club have arguably improved from last campaign.
City sit clear atop the table and will be looking to keep up their recent impressive form against Chelsea – winning on the last three occasions – including a 2-0 victory in this season's FA Community Shield.
City, however, could be without star-striker, Sergio Aguero, who missed out last weekend due to injury, but Guardiola has already had the luxury of rotating his star players and perhaps the absence of Aguero will not be a major factor.
David Silva, Kyle Walker and Riyad Mahrez were all on the bench last weekend, while Benjamin Mendy and Kevin De Bruyne are also still out with injuries. Their strength in depth is scary and Guardiola has kept all his players fresh and adjusted to his system, so while nobody is guaranteed a place in the line-up, every single one of those players are up for it.
If the league had to end now, big debates would surface about who has been City's star performer this season. Raheem Sterling has been exceptional with eight goals and six assists to his name before midweek's fixtures, while the two Silvas – Bernardo and David – have been immense in De Bruyne's absence.
Manchester City have already gone to the Emirates Stadium, Wembley and Anfield and have not conceded a goal, so as brilliant as their attack has been, the back four in front of Ederson deserve massive credit.
Probable line-ups:
Chelsea: 4-3-3
Kepa; Azpilicueta, Luiz, Rudiger, Alonso; Jorginho, Kante, Kovacic; Pedro, Giroud, Hazard.
Manchester City: 4-3-3
Ederson; Walker, Stones, Laporte, Delph; Fernandinho, David Silva, Bernardo Silva; Sterling, Gabriel Jesus, Sane.
Prediction: Manchester City (17/20)
Guardiola's men have been impressive this season and are full value for the win here. In many ways, Sarri's system is similar to that of the Spaniard's, which could favour the more experienced boss in this one. Aymeric Laporte is still yet to lose a Premier League game in a Manchester City shirt, and not only am I expecting that run to continue, but a victory is also on the cards for the champions.
Written by Jesse Nagel
Labels: Chelsea vs Manchester City, English Premier League, Stamford Bridge
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Australia's Submarine Slap To France Exposes Brutal Truth About Europe
The military pact between Australia, the United States and the United Kingdom is further proof that Europe's influence is eroding. To make up for the absence of a collective defense from the bloc's 27, it is urgent to establish alliances with different countries.
France's Suffren submarine in Cherbourg
Maxppp/ZUMA
Lucie Robequain
Geopolitics LES ECHOS Sources Europe featured-post Countries
The slap that Australia, along with the United States and the United Kingdom, has just inflicted on us is a reminder of some disturbing truths — which happen to be opposed to the values we cherish. First of all, it reminds us that in international relations, friends don't exist. There are just allies who share common interests. Europeans have long lived with the illusion that the United States, a brotherly country, would only want the best for us and that Joe Biden had a special bond with the land of his ancestors.
The fact that President Biden convinced Canberra to break its commitments with France's Naval Group shows his determination to follow only one course: that of Washington's economic and commercial interests. From this point of view, Biden's actions are much more damaging than Donald Trump's, because they are more thoughtful and effective. This is actually the second time since the beginning of the summer that the French defense has been snubbed: last June, Americans had managed to impose their fighter planes on Switzerland, to the detriment of France's Rafale.
UK Prime Minister Boris Johnson, U.S. President Joe Biden and Australia Prime Minister Scott Morrison during a G7 meeting in Cornwall on June 12 — Photo: Andrew Parsons/Avalon/ZUMAAvalon/ZUMA
The Australian fiasco teaches us something else: our allies are less scrupulous than us in transferring their technologies. France has always refrained from exporting its nuclear-powered ships, because it sees them as the key to its independence and expertise. By agreeing to share theirs with the Australians, the Americans are breaking a major taboo.
History provides only one precedent, when Washington had offered its atomic expertise to the British. It was 1958, at the height of the Cold War — which says a lot about the anti-China front that is building up today. Will the American-Australian cooperation encourage other countries to develop their nuclear, civilian or military arsenals? Many fear so.
What's most cruel about this whole affair is to realize how much Europe's influence is eroding. Our hesitation vis-à-vis China is pushing the United States to forge alliances elsewhere, and without us. At the same time, they give Boris Johnson a great opportunity to achieve his ambitions to create a "Global Britain."
By contrast, Europe doesn't give any real weight to the common defense it calls for. The resistance of many countries, especially Poland, should push us to establish mini-alliances, as the United States is doing right now. We can only hope that the German election next week will choose a more proactive chancellor than Angela Merkel to actively support this strategic autonomy.
Nuclear Power And The Willful Ignorance Of Germany's Greens ... ›
Disarmament To Rearmament: The Quiet Return Of Nuclear Risk ... ›
France says Biden acted like Trump to sink Australia defence deal ... ›
In Submarine Deal With Australia, U.S. Counters China but Enrages ... ›
France Calls U.S.-Australia Submarine Deal a Betrayal - WSJ ›
Anne Sophie Goninet
France's top business daily, Les Echos covers domestic and international economic, financial and markets news. Founded in 1908, the newspaper has been the property of French luxury good conglomerate LVMH (Moet Hennessy - Louis Vuitton) since 2007.


The test for integer is adapted from this post, which is actually almost spot on, apart from their is_int() returns true, as does any integer in a string.
Please let me know if you can break it!
So if you don't need any of this functionality in your string, you're making PHP do some extra work for no reason.


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Home > Research > Research Areas > Large Synoptic Survey Telescope
The Large Synoptic Survey Telescope (LSST) will be one of the next class of super giant earth-based telescopes. It will be located at Cerro Pachón in Chile. The LSST project is the work of an international consortium of universities and science institutions - including the University of Arizona. Up to date news on the status of the LSST is provided here. Below are links to the expected optical and instrument specifications.
LSST Specifications
Location Specifications
Longtitude
Telescope Specifications
8.4 m per mirror
Altitude/Azimuth
Additional Information on telescope specifications
Additional information regarding optical specifications
Additional information regarding science operations


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is something evil in the house. Adam, though sympathetic is convinced she must be having a nervous breakdown. It is only when Adam calls upon Dr Clark (Delroy Lindo) a professor of parapsychology at the university that the true horror of what they have let out becomes clear. The opening of the box has unleashed a malevolent entity that will stop at nothing until it satisfies its murderous intentions.