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New and Emerging Targeted Therapies Show Promise in Biliary Tract Cancer
Hayley Virgil
Molecular profiling has led to a better understanding of biliary tract cancers by revealing new markers that can be targeted by novel therapies, and several are currently under investigation.
Molecular profiling has led to a better understanding of biliary tract cancers (BTC) by revealing new markers that can be targeted by novel therapies, Milind Javle, MD, said in a presentation during the 17th Annual Meeting of the International Society of Gastrointestinal Oncology, and immunotherapy is now a promising area of research, although predictive biomarkers remain elusive.1
"[Although] molecular-targeted therapies are no longer fashionable in the age of immunotherapy, these agents have made remarkable progress in BTC," said Javle, who is a professor of gastrointestinal medical oncology at the University of Texas MD Anderson Cancer Center. "[Studies have demonstrated] that the genetic profiles of intrahepatic cholangiocarcinoma (CCA), extrahepatic cholangiocarcinoma, and gallbladder cancers are diverse; in fact, 50% of patients have actionable mutations such as FGFR, IDH1, HER2, and BRAF."
Numerous classes of novel therapeutics are currently under investigation that have shown promising responses in patients with BTC, including molecular-targeted agents, liver-directed agents, immunotherapies, and cytotoxics.
IDH1 Inhibitors in IDH1+ Cholangiocarcinoma
In the global, phase 3, randomized, double-blind ClarIDHy trial (NCT02989857), investigators examined the use of the IDH1 inhibitor ivosidenib (Tibsovo) versus placebo in the second-line treatment of patients with advanced IDH1-mutated CCA; crossover was permitted.2
The study met its primary end point of median progression-free survival (PFS). Results showed a median PFS of 2.7 months in the ivosidenib arm versus 1.4 months in the placebo arm (HR, 0.37; CI, 0.25-0.54; P < .001). The 6-month PFS rate was 32% in the ivosidenib arm versus not evaluable (NE) with placebo; the 12-month PFS rates were 22% and NE, respectively. Additionally, the disease control rate DCR, which is comprised of partial response (PR) and stable disease (SD), was 53% in the ivosidenib arm (2% PR, 51% SD) and 28% in the placebo arm (0% PR, 28% SD).
Additionally, the median overall survival (OS) in the intent-to-treat population was 10.8 months in patients who were treated with ivosidenib and 9.7 months in those who received placebo (HR, 0.69; 95% CI, 0.44-1.10; P = .06). The 6- and 12-month OS rates in the ivosidenib arm were 67% and 48%, respectively; these rates were 59% and 38% in the placebo arm, respectively. Final OS data from the trial showed that although there was a trend for improved OS in those who received the IDH1 inhibitor compared with placebo, it was not statistically significant.3
"[ClarIDHy] has led to studies of IDH resistance. [One study] demonstrated in serial biopsies that there's isoform switching, whereas a percentage of patients who had IDH1 mutations and resistance [may switch] to an IDH2 isoform, which will, perhaps, be targetable," Javle explained. "However, at the current time, IDH2 targeting remains experimental."
FGFR Inhibitors in Cholangiocarcinoma
Approximately 15% of CCA, particularly intrahepatic CCA, have mutations in the FGFR pathway, and these mutations are activating; they unleash a downstream of proliferative and resistance mechanisms that can be targeted with small molecule inhibitors, explained Javle.
Patients whose tumors harbor these mutations are often younger, under the age of 40 years. These mutations are also found to be more common in Caucasian patients rather than Asian patients, and there is a distinct pattern of concurrent mutations. Several FGFR inhibitors have been developed across many tumor types including infigratinib, ponatinib (Iclusig), and pemigatinib (Pemazyre), which are being examined in biliary cancers.
The first trial to be conducted in this space was a phase 2 study, in which 71 patients with advanced CCA who received the FGFR inhibitor infigratinib. Patients experienced a DCR of 83.6% with the agent and an overall response rate (ORR) of 31% in patients who received the agent.4
A key player is pemigatinib, which was examined in the phase 2 FIGHT-202 trial (NCT02924376). Patients with advanced or metastatic CCA who had FGFR fusions and rearrangements (cohort A; n = 102) experienced an ORR of 35.5% (95% CI, 26.5-45.35).5 Additionally, 3 patients in this cohort had a complete response (CR; 2.6%), 35 had a PR (32.7%), 50 achieved SD (46.7%), and 16 had progressive disease (15%). The median duration of response was 7.5 months (95% CI, 5.7-14.5), and the DCR was 82% (95% CI, 74-89).
For patients with FGFR2 fusion–positive CCA, infigratinib and pemigatinib have been shown to yield some of the highest ORR rates compared with other FGFR inhibitors such as futibatinib and deranzantinib (ARQ 087), at 25.0% in 45 patients and 20.7% in 29 patients, respectively. Erdafitinib (Balversa), however, has been shown to elicit an ORR of 57.1%, albeit in a smaller number of patients (n = 7).
"These agents are potent," said Javle. "We believe the activity of these agents is higher when you give them earlier in the course of therapy." To this end, several of these agents are being examined in the first-line setting, he added.
"The most common mechanism of resistance is acquired gatekeeper mutations in the ATP-binding pocket of the FGFR," Javle explained. "However, these mutations can also be targeted."
Combination Therapies in BRAF V600-Mutated Cholangiocarcinoma
Although BRAF V600E mutations are only found in 5% of CCA tumors, there is still a need for effective therapies following patient progression on a gemcitabine-based chemotherapy. Due to the fact that dabrafenib (Tafinlar) and trametinib (Mekinist) have shown activity in multiple BRAF V600E–mutated tumor types, the safety and efficacy of the combination was evaluated in patients with BTC in the phase 2 ROAR study (NCT02034110).6
Patients who received the combination therapy (n = 43) experienced an investigator-assessed ORR of 51% (n = 22; 95% CI, 36-67). The independent reviewer-assessed ORR was 47% (n = 22; 95% CI, 36-67). The study not only achieved promising activity within this patient population with the use of dabrafenib plus trametinib, but it also indicated a need for more routine testing to identify BRAF V600E mutations in patients with BTC, noted Javle.
"This is quite similar to the data seen in BRAF V600E-mutated malignant melanoma," Javle said. "Clearly, at this point, every patient who has a BRAF mutation will probably have access to a BRAF plus MEK inhibitor—in this study, dabrafenib and trametinib was examined. This has made it into the National Comprehensive Cancer Network guidelines."
Additional Pathways Under Investigation
Several other pathways under investigation with additional agents being examined in clinical trials. For example, in a phase 2 trial, 309 patients with untreated advanced or metastatic BTC received frontline treatment for up to 8 cycles with the VEGFR2 inhibitor ramucirumab (Cyramza) plus gemcitabine/cisplatin (n = 106, intravenous [IV]), the MET multikinase inhibitor merestinib (LY2801653) plus gemcitabine/cisplatin (n = 102, oral), or placebo plus gemcitabine/cisplatin (n = 52, IV; n = 49, oral).7
Results showed that patients who were given the ramucirumab regimen experienced a median PFS of 6.47 months (95% CI, 5.65-7.13) and a median OS of 10.45 months (95% CI, 8.48-11.86). Those in the merestinib arm had a median PFS of 6.97 months (95% CI, 6.21-7.13) and a median OS of 14.03 months (11.96-16.36). Neither of the experimental arms were found to vastly improve OS or PFS over the placebo regimen, which had a median PFS of 6.64 (95% CI, 5.59-6.83) and a median OS of 13.04 months (95% CI, 11.40-15.31). As such, investigators concluded that the addition of ramucirumab or merestinib to the gemcitabine/cisplatin backbone did not significantly improve PFS, OS, or radiological response within this patient population.
Agents such as olaparib (Lynparza), along with other PARP inhibitors, are also being examined in patients with BRCA1/2 and DNA damage repair mutations. PI3K inhibitors and ATK inhibitors including copanlisib (Aliqopa) are being evaluated in those who are positive for PIK3CA and ATK, while porcupine inhibitors are being tested in patients with RSPO fusions and RNF43 mutations, said Javle. PD-1 and PD-L1 inhibitors are also under exploration in patients who are microsatellite instability–high and high tumor mutational burden (TMB).
Moreover, 2 ongoing phase 2 trials are assessing the efficacy of crizotinib (Xalkori; NCT02034981) and ceritinib (Zykadia; NCT02374489) in advanced CCA and other gastrointestinal malignancies.8,9
Novel Immunotherapies and Tumor Mutational Load
While PD-1 and PD-L1 are being tested in patients who have a high TMB, TMB tends to be generally low in this patient population, noted Javle. "When we looked at over 1000 patients across several sites of TMB, it is relatively low," Javle said. "Only 5%-7% of patients have high or intermediate TMB." Regardless, immunotherapy is an active area of investigation.
In the phase 2 BilT-01 study (NCT03101566), investigators evaluated nivolumab (Opdivo) in combination with either ipilimumab (Yervoy) or gemcitabine/cisplatin in patients with advanced unresectable BTC.10 Here, 36 patients received nivolumab at 360 mg every 3 weeks plus gemcitabine/cisplatin and 32 patients received nivolumab at 240 mg every 2 weeks with ipilimumab at 1 mg/kg every 6 weeks.
Results showed a 6-month PFS of 64.2% in patients who were treated with nivolumab plus gemcitabine and cisplatin versus 23.4% in those who received the dual immunotherapy. While nivolumab plus ipilimumab was not found to be superior to nivolumab plus gemcitabine/cisplatin, the combination was concluded to be as efficacious as standard-of-care chemotherapy in this patient population, concluded Javle.
Javle M. Updates on new and emerging targeted therapies in biliary tract cancer. Presented at: 17th Annual Meeting of the International Society of Gastrointestinal Oncology; October 2-3, 2020; Virtual.
Javle M, Bekaii-Saab T, Jain A, et al. Biliary cancer: utility of next‐generation sequencing for clinical management. Cancer. 2016;122(24):3838-3847. doi:10.1002/cncr.30254
Abou-Alfa GK, Macarulla Mercade T, M Javle , et al. ClarIDHy: A global, phase 3, randomized, double-blind study of ivosidenib (IVO) vs placebo in patients with advanced cholangiocarcinoma (CC) with an isocitrate dehydrogenase 1 (IDH1) mutation. Ann of Oncol. 2019;20(suppl_5):v851-v934. doi:10.1093/annonc/mdz394
Agios announces final overall survival data from phase 3 ClarIDHy study of TIBSOVO (ivosidenib tablets) in previously treated IDH1-mutant cholangiocarcinoma patients. News release. Agios Pharmaceuticals, Inc. September 21, 2020. Accessed September 22, 2020. https://bit.ly/3cjvA6I.
Javle M, Kelley RK, Roychowdhury S, et al. Updated results from a phase II study of infigratinib (BGJ398), a selective pan-FGFR kinase inhibitor, in patients with previously treated advanced cholangiocarcinoma containing FGFR2 fusions. Ann Oncol. 2018;29(suppl_8):VIII720. doi:10.1093/annonc/mdy424.030
Vogel A, Sahai V, Hollebecque A, et al. FIGHT-202: a phase 2 study of pemigatinib in patients (pts) with previously treated locally advanced or metastatic cholangiocarcinoma (CCA). Ann Oncol. 2019;30(suppl_5):v851-v934. doi:10.1093/annonc/mdz394.
Subbiah V, Lassen U, Élez E, et al. Dabrafenib plus trametinib in patients with BRAF V600E-mutated biliary tract cancer (ROAR): a phase 2, open-label, single-arm, multicentre basket trial. Lancet Oncol. 2019;21(9):1234-1243. doi:10.1016/S1470-2045(20)30321-1
Valle JW, Bai LY, Orlova R, et al. Ramucirumab (RAM) or merestinib (MER) or placebo (PL) plus gemcitabine (GEM) and cisplatin (CIS) as first-line treatment for advanced or metastatic biliary tract cancer (BTC): a randomized, double-blind, phase II study. J Clin Oncol. 2020;38(suppl 4):477-477. doi:10.1200/JCO.2020.38.4_suppl.477.
Phase 2 study assessing efficacy and safety of crizotinib in patients harboring an alteration on ALK, MET or ROS1 (AcSé). ClinicalTrials.gov. Updated October 21, 2019. Accessed October 2, 2020. https://clinicaltrials.gov/ct2/show/NCT02034981.
A phase II trial of LDK378 in ROS1 and /or ALK over-expressed advanced intrahepatic or hilar cholangiocarcinoma. ClinicalTrials.gov. Updated April 5, 2018. Accessed October 2, 2020. https://clinicaltrials.gov/ct2/show/NCT02374489.
Sahai V Griffith KA, Beg MS, et al. A multicenter randomized phase II study of nivolumab in combination with gemcitabine/cisplatin or ipilimumab as first-line therapy for patients with advanced unresectable biliary tract cancer (BilT-01). J Clin Oncol. 2020;38(suppl 15):4582. doi:10.1200/JCO.2020.38.15_suppl.4582

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Aryballe (www.aryballe.com), the pioneer in digital olfaction, today announced a new high-volume, low-cost universal odor sensor, capable of detecting any odor in near real-time. Built on a silicon photonics platform, Aryballe's new sensor is ideal for the automotive and consumer appliances industries due to its miniature enabling companies to develop innovative solutions for new consumer application challenges.
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"Aryballe has been a leader in digital olfaction since our founding with a commitment to delivering products that enable our customers to make smarter and more informed business decisions," said Sam Guillaume, CEO, Aryballe. "We dramatically reduced the size and cost of our newest device to further provide companies in consumer-facing industries with options they never had before. Now, our customers benefit from a much wider range of potential use cases, all of which improve the user experience as well as their bottom line."
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© 2021 Aryballe technologies


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By John Rolls (Reporter)
"Q" [Trust the Plan] Mueller Is About Done, No Report, No Collusion, Democrats Struggle & Fear the Next Move by Trump: Capt. Dave Bertrand, Ret. +Videos
Tuesday, February 12, 2019 13:51
BERTRAND DAILY REPORT The War For Your Mind & Soul Continues
By Capt. Dave Bertrand, Ret.
Friends and Associates:
Trump's former lead attorney, John Dowd told ABC "I don't think there will be a report," referring to the Mueller "Witch Hunt" that has plagued America for over two years. He goes onto say…..
"I know exactly what [Mueller] has," Dowd said. "I know exactly what every witness said, what every document said. I know exactly what he asked. And I know what the conclusion or the result is," he said, describing the sweeping efforts by Trump's legal team to assess the case by speaking to dozens of witnesses. Based on that knowledge, Dowd said, "there's no basis. There's no exposure. It's been a terrible waste of time."
In the meanwhile…the Dems need something, anything to justify their actions against this president.
"Q" has said several times, [Stage Is Set] and last night at the Trump Rally in El Paso, the "stage is set" was stated by Trump and followed by a "Q" sign with his right hand, including reaching-out to a woman wearing a "Q" WWG1WGA cloth on her t-shirt, since "Q" t-shirts are banned from Trump Rallies due to possible security concerns by those attempting access to a Trump Rally with bad intentions, but yet a few bad ones with Trump Derangement Syndrome enter rallies wearing red MAGA hats anyway….so figure !
"The stage is set," is also a tactic used by law enforcement to trap criminals by individually inviting them to some type of event where they have won a cash prize of sorts, only to walk through the door when handcuffs are the surprise.
The Dems walked into the trap set by the "Q" patriots working behind the scenes, creating events and situations that forces a calculated response. The Wall gets built [regardless] of any attempt by the Dems to stop the Wall and have now agreed to meet Trump (somewhat) halfway on a barrier/wall funding agreement of approximately $1.375 Billion Dollars, plus a much smaller gap on the amount of detention beds for illegal alien criminals. The 16,500 number proposed by the Dems is now closer to 50,000 beds.
The 5,000 less detention beds, proposed by the Dems, could increase slightly after Wednesday when the full Budget Plan is written for Trump's consideration. He is likely to accept the $1.375 Billion, as a bonus towards the needed (final) funding which Trump can get from declaring a National Emergency, of which the sticking point by the Dems (in the budget agreement) is to force Trump to curtail a National Emergency.
Senator Burr told NBC News, his committee is preparing to conclude its investigation into whether the Trump campaign colluded with Russia — no direct evidence of a conspiracy.
With the recent announcement(s) by Senator Burr and Attorney Dowd of "No Report, No Collusion," and the Dems suggesting, "No Shutdown" of the government this Friday the 15th, the Future's market surged. However….we shall see.
Stocks Surge As Senate Intel Committee Confirms "No Collusion"
https://beforeitsnews.com/v3/economics-and-politics/2019/2515680.html
Senate Intel Committee Chairman Richard Burr say's it's over…"no collusion, no report."
"If we write a report based upon the facts that we have, then we don't have anything that would suggest there was collusion by the Trump campaign and Russia," said Sen. Richard Burr, R-N.C., the chairman of the Senate Intelligence Committee, in an interview with CBS News last week.
Burr was careful to note that more facts may yet be uncovered, but he also made clear that the investigation was nearing an end.
"We know we're getting to the bottom of the barrel because there're not new questions that we're searching for answers to," Burr said."
The Dems want(ed) the "context" of Mueller's report, before the public sees it, so that it could be used to further the alleged "collusion" conspiracy theory by digging deeper into Trump's former business arrangements, including anything they could conjure-up about Trump's children.
Now the Dems will take the charade another step higher with the same allegations, and because of "no report" expected from Mueller, opens the door for outlandish and far reaching conclusions for anything related to Russia, no matter if Trump's business dealings around the world are legal or not from many years back.
"Q" analysts agree the plan is in place, using Mueller and his several arrests of those "lying to congress" as the basis for going after Comey, McCabe, Clapper, Clinton, et al for "lying to congress" and making it stick…..which the Dems cannot cry foul later when the arrests begin.
We cannot conclude (thus far) if Mueller is actually a "black hat" or a "grey hat" maneuvering the low hanging fruit on the tree into "Process Crimes" in-order to take-down the top players later….but we do know that Mueller is guilty of criminal crimes himself, including the Uranium One scandal, when he was the FBI Director….plus the cover-up of the Jeffery Epstein child rape case with a slap-on-the-hand sentence of 13 months with 16 hours a day freedom to leave the jail, hence….the fact that Mueller visited with Trump before the "Witch Hunt" began suggests, they made a deal which has now backfired on the Deep State.
For you "Q" deniers with (absolutely) no evidence (NONE) to suggest "Q" is a fake, just look back at previous posts before the mid-terms where the (team) told us what the outcome would be in the Senate [53-47] and the Senate was the prize. Therefore….today, the Senate is concluding there was "No Collusion" and forces Mueller to wrap-up his investigation that has gone no-where, and now forces the Dems into a corner, which is exactly [The Plan].
Last night at the Trump Rally, you can watch certain segments revealing what is coming….especially when thousands chanted "Lock Her Up !"
It's just a matter of time when Trump will end his rally speech with…."where we go 1, we go all" and that will seal the conspiracy as proven fact for the "Q" deniers living under rocks. [Enjoy The Show]
WWG1WGA
—Dave Bertrand
(Mark 1:40 [You Saved Our Country] with a sign of "Q")
WATCH [LIVE]: Trump holds campaign rally in El Paso, Texas (Feb 11th, 2019) – Video
Latest Qanon Posts 2-12-19 Pt3 : El Paso Aftermath…. (From Australia) – Video
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Total 1 comment
DangerWillRoberson
yeah ok but some of us want real material evidence not innuendo and conjecture dave? i am leaning to the fact Q is real? but we need heads to roll down the Lincoln memorial steps ! hillary obama, bush! after conviction on Treason!
Feb 12, 2019, 5:52 pm 0 Reply
Growers Express expands recall; doesn't name vegetable supplier
Refreshing a Stale Relationship: 4 tips embedded in a story.
The Best Podcasts to Listen to for Every Mood
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Google Covering Up Ritual Sacrifice Court On Epsteins Island
Video – How use of new domain extensions can spur growth
New Material To Terraform Mars to Make It Habitable
Cornmeal Crusted Cod Cheeks
Trump update 7/16/2019.. I don't have a Racist bone in my body!
Stanton the Federal Dictator
three shining dragon eggs
Never Again: 1,000+ Jews Protest ICE In Washington, DC


text:
Q: Importing any .d.ts results in runtime error There's something simple in TypeScript I'm missing here...
Using Chrome to run my code, I have a working typescript environment and all of my other code/modules are working as expected.
When I import from a .d.ts, everything compiles with no errors/warnings, but I get a runtime error in Chrome, because the generated JavaScript is trying to import from a non-existing file.
import { doSomething } from "exampleJsLibrary";

which fails in the browser because TypeScript doesn't turn exampleJsLibrary.d.ts into a JS file.
I'm targeting es5, using es6 module output, and using tsc to build (no webpack/browserify tools), ts 2.7.2.
Full example:
<!DOCTYPE html>
<html>
    <head>
    <script>
            var exampleJsLibrary = (function() {
                return {
                    doSomething: function(x) { return x + 1 }
                }
            })()
    </script>
    <script type="module" src="./built/myCode.js"></script>
    </head>
    <body>
    </body>
</html>

and
// exampleJsLibrary.d.ts
export const doSomething(x: number): number;
export as namespace exampleJsLibrary;

// myCode.ts
import { doSomething } from "./exampleJsLibrary";
function test() {
    console.log(doSomething(3));
}

// tsconfig.json
...
        "target": "es5",
        "lib": ["dom", "es5", "es2015.iterable", "es2015"],
        "outDir": "built",
        "module": "es6"
...

The failure occurs because the generated code for myCode.js
still has the line import { doSomething } from "./exampleJsLibrary",
which causes a runtime error because there is no exampleJsLibrary or exampleJsLibrary.js.
If I replace that line in the generated JS with var doSomething = exampleJsLibrary.doSomething, everything works.
How do you import from a .d.ts?

A: .d.ts declaration files just contain type declarations, not the actual code. (They're like header files in C/C++, if you happen to be familiar with that.) You'll need to include the actual library code in your project and either import it or have it defined globally to make it work at runtime.
In your case, since the library code is included on the page as a global, you don't need to use import. Instead you can just say:
const doSomething = exampleJsLibrary.doSomething

If the compiler complains that exampleJsLibrary is not defined, the simplest fix is to add this at the top of your file (use the actual relative path to the .d.ts):
/// <reference path="path/to/exampleJsLibrary" />

(Note that the approach is different if your package is included from npm, which is pretty common.)

redpajama_set_name: RedPajamaStackExchange


User onboarding is a very delicate process. Recognising where it begins is easy because the very first step is for a new user to signup, but where exactly does user onboarding end?
User onboarding is your user's initial experience with your brand, product, and people.
It spans from the moment someone starts to sign up for your product, until the moment they realize how your product is going to improve their life, or their "Wow moment".
The problem with aha or wow moments is that they're difficult to identify because they don't really exist.
User onboarding is the process of increasing the likelihood that a user receives what you promised him from your app (aka the 'aha' or 'wow' moment).
Keeping this definition in mind, when looking to define where your user onboarding ends, the best place to start is your website.
What is your website promising to your users?
At Buffer, the onboarding process ends when a user is able to share their first bit of content through Buffer.
At that moment she can decide if the initial promise of "share smarter" is true and if it helps her.
The onboarding process at Slack ends when a user manages to communicate his first message to his team.
That means the user will probably need to add team members, send them a message and also hear back from them.
It's at this moment that the user can judge if he wants to give Slack a chance or not.
The onboarding process at Freshbooks ends when a user issues his first invoice.
It's at that point that he can see how much of an accountant he does (or doesn't!) need to be to use the product.
The onboarding process at Get Response ends when a user sends his first email campaign.
It's at that point that he can decide if it really was easier than what he was using previously or, if this is his first time sending a campaign using any platform, if it felt easy for him.
Inbound: Where smart marketers hang out.
Identifying where the onboarding process ends at Inbound is a little trickier because "hanging out, staying current and connected" can mean different things for different users.
However, for any community to exist, users need to share so, for Inbound, the user onboarding process ends when users share at least one bit of content with the community, be it a comment or an article.
At that point they can decide if the community is for them, and if it's worth staying around.
The reason companies put a lot of effort into user onboarding is because onboarding is a mandatory step before converting the user into a customer.
In fact, the onboarding experience will have a direct impact on converting users to customers.
That's why, when dealing with and reporting on the performance of the user onboarding process, it's important not to focus solely on the funnel that users go through while onboarding.
A very important question is: how many of the onboarded users come back to the app?
Users created an account because they wanted what was promised to them.
They went through every step that they needed to in order to receive what was promised from the app.
Whether he decides to return (or not) is an indication of whether he believes you have delivered on your promises.
And now it's your turn: Take a look at your own website and tell me in the comments where you think your user onboarding ends. I'll gladly offer feedback.
Next Next post: Product Manager vs. Marketer: Who's In Charge of User Onboarding?


Though Fox Searchlight has already release The Grand Budapest Hotel in theaters, the film is poised to hit Blu-Ray & DVD next week on June 17th. Normally these occasions aren't worth writing about, but in order to celebrate the release of the Wes Anderson comedy, the studio commissioned a huge LEGO version of the title hotel. Ryan Ziegelbauer and a team of eight builders put the model together, and as the featurette below indicates, they spent 575 hours building and designing the replica. It's composed of more than 50,000 certified LEGO bricks from collectors and wholesalers from Lithuania, Poland, Latvia, Germany, Italy and 14 different states in the U.S. Now we just wish they would sell this in stores. Watch!
The Grand Budapest Hotel is written and directed by Wes Anderson (The Royal Tenenbaums, Moonrise Kingdom, Rushmore) and tells of a legendary concierge at a famous European hotel between the wars and his friendship with a young employee who becomes his trusted protégé. The story involves the theft and recovery of a priceless Renaissance painting, the battle for an enormous family fortune and the slow and then sudden upheavals that transformed Europe during the first half of the 20th century. Fox Searchlight released The Grand Budapest Hotel in theaters on March 7th and it hits Blu-Ray & DVD on June 17th.
Just rewatched THE GRAND BUDAPEST HOTEL. Wow! What a film. Really. Lego is really on a role with their pop culture infiltration. Shame about their insistence on making Ninjago a thing.


text:
The Company is defined as Blush Bridal (Fraserburgh) Limited, company number SC475608, whose registered office is 4 Robbies Walk, Fraserburgh, AB43 7BJ. The principal activity of the company is the sale of bridal and special occasion dresses.
This Policy outlines the Company's obligations regarding the collection, processing, transfer, storage and disposal of Personal Data. The procedures and principles set out herein must be followed at all times by the Company, its employees, agents, contractors, or other parties working on behalf of the Company.
The Company acknowledge its responsibility in respect of GDPR regulations and as data holders. In terms of how we use your information, we use it for the following reasons:
To deliver our products
To collect and recover money that is due to us.
To manage supplier payments
To undertake the operations of our business in an efficient manner
To comply with all applicable UK legislation.
We collect data from our customers via face to face meetings at our premises and via telephone calls and email correspondence. We do not share this data with third parties, without the consent of the subject to whom the information relates. Contractual information is held for a period of seven years, as required by UK law.
The Company is committed not only to the letter of the law, but also to the spirit of the law and places high importance on the correct, lawful and fair handling of all Personal Data, respecting the legal rights, privacy and trust of all individuals with whom it deals.
This Policy aims to ensure compliance with the GDPR. The GDPR sets out the following principles with which any party handling Personal Data must comply. All Personal Data must be:
Processed lawfully, fairly and in a transparent manner in relation to the Data Subject.
Collected for specified, explicit and legitimate purposes and not further processed in a manner that is incompatible with those purposes. Further processing for archiving purposes in the public interest, scientific or historical research purposes or statistical purposes shall not be considered to be incompatible with the initial purposes.
Adequate, relevant and limited to what is necessary in relation to the purposes for which it is processed.
Accurate and, where necessary, kept up to date. Every reasonable step must be taken to ensure that Personal Data that is inaccurate, having regard to the purposes for which it is processed, is erased, or rectified without delay.
Kept in a form which permits identification of Data Subjects for no longer than is necessary for the purposes for which the Personal Data is processed. Personal Data may be stored for longer periods insofar as the Personal Data will be processed solely for archiving purposes in the public interest, scientific or historical research purposes, or statistical purposes, subject to implementation of the appropriate technical and organisational measures required by the GDPR in order to safeguard the rights and freedoms of the Data Subject.
Processed in a manner that ensures appropriate security of the Personal Data, including protection against unauthorised or unlawful processing and against accidental loss, destruction, or damage, using appropriate technical or organisational measures.
We keep this privacy statement under regular review, and will update as required. A written copy can be provided on request.
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We use an invisible captcha service named reCAPTCHA. reCAPTCHA is operated by Google.
The reCAPTCHA service may collect information from You and from Your Device for security purposes.
The information gathered by reCAPTCHA is held in accordance with the Privacy Policy of Google: https://www.google.com/intl/en/policies/privacy/


text:
Trump's Budget Would Cut Millions in Assistance for Business Owners
In addition to other cuts, the White House wants to reduce the Small Business Administration's funding by 5 percent.
By Emily CanalStaff writer, Inc.com@emilycanal
Donald Trump.
President Trump will send a budget proposal to Congress on Thursday that could reorganize the nation's priorities by putting an emphasis on defense spending while cutting funds for numerous agencies--including some important to the fortunes of business owners.
Preliminary budget documents show the White House wants to cut $43.2 million, or about 5 percent, from the Small Business Administration's budget, according to The Washington Post. The reduction would wipe out $12 million worth of technical assistance grants and other programs the administration believes already are adequately supplied by the private sector. It also would decrease the amount of loan guarantees to small-business owners from $46 million to $45 million.
"The president is committed to assisting small businesses through reducing the regulatory tax burdens that can impede the development of small firms," the Trump administration told the Post.
Trump advisers reportedly also have explored tightening the Commerce Department's budget by about 18 percent. In all, Trump identified 62 programs and agencies that would be eliminated, including two from the Department of Commerce.
The Economic Development Administration, which now receives $221 million a year, is on the chopping block. Trump's proposed budget says the EDA has "limited measurable impacts and duplicates other federal programs," according to USA Today. What's more, the White House says the Minority Business Development Agency, which receives $32 million a year, is duplicative of other programs in the Small Business Administration.


Hello. My name is David Concepcion, and while I was never one of your constituents, I am a New Yorker now living in New England. I admit I've never been a fan of your policies as Mayor of New York City, but I am impressed by your efforts to deal with gun violence in the aftermath of the Sandy Hook massacre in Newtown, CT. Your organization Mayors Against Illegal Guns (founded with the late Boston Mayor Tom Menino), which is now Everytown for Gun Safety, has been particularly good in promoting "common sense" gun laws and putting it into the public debate in a positive way. It is because of this stance and Everytown for Gun Safety's analytical work why I write you for help.
Right to the point: America is in trouble. You know this because you've seen the statistics: we've have more mass shootings in 2015 than we've had days (356 shootings as of 12/8/15, the 342nd day of 2015); that the numbers of Americans people killed by firearms since 2001 is equal to the number of all American soldiers killed in WWII (400,000); and this year alone, the Centers for Disease Control and Prevention (CDC) expects the gun death total this year to be 33,000—or 3,200 people per week. The numbers are horrifying, yet our elected representatives are too afraid or beholden (or both) to do anything to stem the tide. While 80% of National Rifle Association (NRA) members support the almost 90% of Americans who want some common sense gun control measures in place, we seem to be at the mercy of that minority of gun owners and all gun lobbyists who feel any gun law is a slippery slope to losing our Second Amendment rights. What you and Everytown for Gun Safety are doing to counter the NRA is admirable and which is why this open letter is mainly directed towards you and your group.
I know that serious gun control laws will not happen until 2017, when a new Congress convenes that may have the political will and ability to do anything helpful for America. Personally, I don't like guns at all, but I'm happy to accept what my NRA member buddies have suggested—expanded background checks, listing of all private gun sales, closing the terrorist and gun show loopholes, and a ban on high capacity magazines. Unfortunately too many innocent Americans will die by gunfire until that time. So I have a proposal that will fill the gap and prepare the public and other advocates for the future legislative fight.
The best tool that public safety officials have right now is health statistics. From smoking deaths to deaths by car accidents, comprehensive statistics illustrating the dangers of behaviors and/or items or substances have been indispensable to informing public opinion and policy. However for the last 20 years, the CDC has been barred by Congress from conducting ANY studies into gun violence and/or gun deaths whatsoever. Even the statistics from the Everytown for Gun Safety website had to by culled and extrapolated from FBI, police, hospital, and other databases. The CDC is one of the best organizations to study the issue of gun violence and a public health issue, but are unable to proceed due to the loss of federal funding the Centers need to keep operating. My proposal is this: since the CDC is barred from pursuing an accurate health study and this Congress will not lift the funding ban, I ask you to use a small portion of your considerable wealth to fund a national public health study in to gun deaths and gun violence in America, as well as the real life impacts—physical, emotional, and economic—these have on Americans.
In 1995, the CDC was prepared to spend $2.6 million on such a study, which is what is what public research funds are available today for firearms study. Adjusted for inflation, that $2.6 million would equal $4.1 million today. I suggest using $5 million to fund that important national study that was planned, and use the same CDC protocols to ensure accuracy and proper peer review. The results of the study would be of great use to the 2017 Congress and our next president, who may then fully act upon the results. While many call this "advocacy research," it can serve as a study on how guns impact the daily lives of Americans, especially if done within correct protocols. It is a step in the right direction for all parties on either side of the debate as it will educate the public and policymakers alike, and can enhance the debate for "common sense" control laws. At the very least, the conversation can be faced honestly and without interference.
We all know why nothing has been done about guns and gun violence even after the death of 20 children in one school. It's because a group like the NRA has an iron fisted hold on those who could do something. The NRA keeps the pressure on lawmakers to sustain the ban on studying gun violence not as a way to protect gun owners, but as a way of protecting the gun manufacturers that they really represent. Money has seeped into the process and corrupted the workings of policy to hold us all hostage, and America loses as a result. Until such a time that money is driven out of politics, it seems the only thing that can stop a bad lobbyist group with money and power is a good lobbyist group with money and power. Mr. Bloomberg, please use a tiny portion of your considerable wealth to fund a national public health study into the full extent of damage to people and society by gun violence. This is a giant opportunity to help America in the middle of a deadly epidemic. I plead with you as a patriotic American to answer the call.
cc: Bill & Melinda Gates Foundation, George Soros, Warren Buffet, and any philanthropist who recognizes that "ensuring domestic tranquility" and "promoting the general welfare" are equally important parts of the Constitution as the 2nd Amendment.
The Unitarian Universalist Church of Medford, MA will be putting up a Black Lives Matter banner in the next couple of days. Part of the service today was dedicated to blessing the banner. As one who asked for the banner, I was asked to lead the blessing and say a few words about needing to raise this banner.
Earlier this fall, I asked Rev. Tess if we could put up a Black Lives Matter banner at the church. I didn't ask because of any one particular death of a Black person at the hands of the police—despite the many that can be named: Tamir Rice, Laquan McDonald, Eric Garner, Michael Brown, Sandra Bland; and the list goes on. I asked about a banner after what happened to a Unitarian church in Reno, NV. Their minister, Rev. Neal Anderson, is a friend of mine and I heard that they dedicated their third Black Lives Matter banner after their first two banners were vandalized and stolen respectively. Despite each time this majority White church had their banner ruined or taken, they put up another one with the same blessings and commitment as they put up their first one, because it was part of the commitment that church made to support social justive. I felt as we at this church believe in working for social justice, a banner is the least we could do.
In 1930s occupied Europe, the Unitarian flaming chalice had become an underground symbol for assistance to help Unitarians, Jews and otheers to escape Nazi persecution. We currentlly have a rainbow flag signifyingus as allies to the LGBT communities, and at one point we had a sign on the post that read "all welcome." The question is not why don't we have a Black Lives Matters banner, but why have we not put one up sooner?
As I said in a sermon this summer, ours is a covenental religion, meaning we practice our faith in the promise of how we treat each other. We have always shone a light on injustice and as a beacon of hope. At the rate that Black people are killed at the hands of those sworn to protect and serve the public, they are inneed of hope. By hanging this banner for all to see, we give hope because we stand in solidarity with those oppressed until such oppression is held accountable.


Get a free packet of Organic Lettuce Seeds! Tasty Bite is giving away 30,000 packets of free organic lettuce seeds to anyone who pledges to grow and share their harvest with a local food pantry. Find your local pantry on the lower left, select it and complete the sign up form. Your seeds will be mailed in the next 2 weeks.


text:
<?php

namespace ReferenceIntegrity\Fixture\Document\OnePull;

use Doctrine\Common\Collections\ArrayCollection;
use Doctrine\ODM\MongoDB\Mapping\Annotations as ODM;

/**
 * @ODM\Document(collection="articles")
 */
class Article
{
    /**
     * @ODM\Id
     */
    private $id;

    /**
     * @ODM\Field(type="string")
     */
    private $title;

    /**
     * @ODM\ReferenceMany(targetDocument="Type", simple="true", inversedBy="articles")
     * @var ArrayCollection
     */
    private $types;

    public function __construct()
    {
        $this->types = new ArrayCollection();
    }

    /**
     * @return mixed
     */
    public function getId()
    {
        return $this->id;
    }

    /**
     * @param string $title
     */
    public function setTitle($title)
    {
        $this->title = $title;
    }

    /**
     * @return string
     */
    public function getTitle()
    {
        return $this->title;
    }

    /**
     * Add types
     *
     * @param Type $type
     */
    public function addType(Type $type)
    {
        $this->types[] = $type;
    }

    /**
     * Get posts
     *
     * @return ArrayCollection $types
     */
    public function getTypes()
    {
        return $this->types;
    }
}

redpajama_set_name: RedPajamaGithub


BREAK NEW GROUND: Designed to simplify even the most complicated recoveries, the 60/80SR features an oversized version of the proven Slider System, combined with a gigantic V-shaped boom and 60,000 lb planetary winches. Now you get power and efficiency that will allow you to work more recovery sites than any other competitor. One step above all other rotator trucks, the power and technology of this work beast will let you reach, lift, and pull anything imaginable including what you once thought was impossible!
Reach past tailgate (3rd stage) : 485 "
Maximum Boom working height (3rd stage) : 664 "


From beloved and bestselling author-illustrator Eric Carle comes a box set with six favorite board book classics.
Carle's signature colorful collages have delighted children for generations, and this is the perfect gift for baby showers and new parents!
With simple, engaging text, these Carle favorites include concepts to help teach young readers more than just reading! 10 Little Rubber Ducks is about counting, Do You Want to Be My Friend? portrays companionship, Does a Kangaroo Have a Mother, Too? illustrates every mother's love for their child, From Head to Toe focuses on actions, The Mixed-Up Chameleon teaches about colors and body parts, and The Secret Birthday Message tackles shapes.
Eric Carle is the creator of more than seventy picture books for young readers.
Eric Carle was born in New York, USA. However, when he was just six, he moved with his parents to Germany. In 1952, after graduating from the prestigious Akademie der Bildenden Künste in Stuttgart, he fulfilled his dream of returning to New York.
Eric Carle has received many distinguished awards and honours for his work, including, in 2003, the Laura Ingalls Wilder Award for his lifetime contribution to children's literature and illustration.
In 2002, fifty years after Carle's return to the United States, The Eric Carle Museum of Picture Book Art was opened in Amherst, Massachusetts. Here visitors of all ages can enjoy, in addition to Eric Carle's work, original artwork by other distinguished children's book illustrators from around the world.


This butter contains an amazing combination of citrus essential oil scents. We combine a variety of wonderful butters with fantastic oils to create a smooth butter that feels great going on and will keep your skin moisturized. We infuse calendula and chamomile into separate oils, a process that takes 4 weeks, before adding them to the butter, to achieve even more skin nourishing benefits. Please allow a few minutes for the butter to fully absorb after it is applied. A little goes a long way.
This container of body butter will last a good long time and has a wonderful citrus scent that you will love.


Overview: From kids playing to actors on the stage and screen, performance has been an essential part of storytelling for centuries. But until now, entertainment has largely focused on telling stories to an audience who sits around the fire and watches. Video games allow players to become performers, to take on the personae of larger than life characters. Tricks have been developed by directors to support this transformation in actors, enticing them to embrace the meaning of a work. Jeffrey will explore method acting techniques, how they apply to games, and how Far Cry 3 directs the meaning of the game.


text:
Home > News > India
Telangana: Polls to 120 Municipalities, 10 Municipal Corporations to be held on Jan 22
As per the updates from the EC, the last day for filing nominations is 10 January, and the last date for withdrawal of candidature is 14 January.
Published: December 23, 2019 9:51 PM IST
By India.com News Desk Email
Edited by Manmath Nayak Email
New Delhi: Elections to 120 municipalities and 10 municipal corporations will be held in Telangana on January 22, the state election commission said on Monday. The counting of votes will take place on January 25.
As per the updates from the EC, a notification in this regard will be issued on January 7, the EC added. For the smooth conduct of the polls, the Model Code of Conduct will come into force with immediate effect, the EC further stated in the release said.
The polls to the municipalities and municipal corporations will be a litmus test for the Bharatiya Janata Party (BJP) to see whether the part is growing in the state or not.
The number of municipalities that will go to polls this time is more this time as the state has created 23 new districts (there were 10 earlier).
For breaking news and live news updates, like us on Facebook or follow us on Twitter and Instagram. Read more on India Latest News on India.com.
Telangana Encounter: High Court Orders Re-postmortem of Bodies of Hyderabad Rape Accused
Telangana CM Chandrasekhar Rao Pays His Condolence on Telugu Actor-Writer Gollapudi Maruti Rao's Death
Published Date: December 23, 2019 9:51 PM IST


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Professor named finalist for Technology Association of Iowa award
November 16, 2016 • Emily Benda
Agricultural and Biosystems Engineering Awards (other) CoE in the Media CoE News Electrical and Computer Engineering
Rover (right) with Alexis Slade, finalist and the student Rover nominated for the Collegian Innovation & Leadership award.
Iowa State University Department of Electrical and Computer Engineering Professor Diane Rover was recognized as a finalist for the Technology Association of Iowa (TAI) award in the Diversity Champion category on Thursday.
The TAI awards recognize and celebrate women who are leaders in the fields of science, technology, engineering and math.
Rover has been an advocate through several roles to improve diversity at Iowa State University, regionally and nationwide. She currently serves as the alliance director for the National Science Foundation (NSF) Iowa Illinois Nebraska STEM Partnership for Innovation in Research and Education Louis Stokes Alliance for Minority Participation (IINSPIRE LSAMP), a program committed to broadening the participation of underrepresented minorities in science, technology, engineering and mathematics (STEM) education in the Midwest.
Rover also serves as co-chair of the Accreditation Board for Engineering and Technology, Inc. (ABET) Engineering Accreditation Criteria Committee and is working to revise accreditation criteria. She is addressing the goals of creating a collaborative and inclusive environment for teams to include individuals of diverse backgrounds, skills or perspectives.
Anson Marston Distinguished Professor in Chemical Engineering Surya Mallapragada said Rover's work with IINSPIRE LSAMP as alliance director has helped broaden the participation of minorities pursuing STEM degrees. Her involvement has significantly impacted the engineering community and underrepresented minorities, Mallapragada said.
"I nominated her because she has been a diversity champion through her many activities, including leading the LSAMP effort, which has had a significant impact," Mallapragada said.
Rover said she was honored to have been a finalist for the Diversity Champion Award by the Technology Association of Iowa.
"Their Women of Innovation Program is an inspiration to all involved and highlights the talent we have in the state of Iowa," Rover said. "It's especially rewarding for me to give back to diversity and inclusion efforts. I believe we all need to be diversity champions in our workplaces and communities."


In addition to bringing your questions and thoughts to this first ever ALA Intellectual Freedom Chat (#ALAIFchat) on Monday evening, December 17 at 7 p.m. CST, please comment below if there are specific questions you'd like us to address. Use the hashtag #ALAIFchat to participate.
While the focus will be on reporting censorship in libraries, schools, and other public organizations, anyone is welcome to join us to learn more about how the American Library Association tracks bans and challenges to materials and resources and why it is so important to support the freedom to read and speak out against censorship.
Kristin Pekoll is the Assistant Director of ALA's Office for Intellectual Freedom. Kristin communicates with state library associations on current book challenges and publications that deal with censorship, privacy, ethics, and internet filtering. She organizes online education and training on the freedom to read and how to navigate reconsideration requests and media relations. Kristin started her career as a youth librarian in West Bend, Wisconsin. In 2009, over 80 YA LGBTQ books were challenged over 6 months. While the library board voted to retain all of the books in this case, she learned the indispensable value of support and education for librarians. She continued to fight against censorship in Wisconsin as the Intellectual Freedom Round Table Chair. Kristin's husband and kids have joined her in Chicago but they all remain true Green Bay Packers fans. She enjoys zombies, knitting, and the Big Bang Theory. Find her on Twitter @kpekoll.


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Black Listed, News & Politics, What's Happening Now
The Justice Department Might Not Keep Darren Wilson from Walking Free
A non-indictment tosses the ball back to the Justice Department. U.S. Attorney General Eric Holder certainly has had a firm and visible handprint all over the Brown killing case. He quickly flooded Ferguson with teams of federal investigators in the aftermath of the killing, ordered an autopsy of Brown and made several high-profile appearances in Ferguson and St. Louis. He's also filed civil rights charges against nearly 400 cops during his tenure. That number far exceeds the number filed during the George W. Bush years. Holder certainly could make the case that Wilson abused his power in killing Brown under the cover of law, and that this violated several key civil rights statutes. This is the linchpin of federal prosecutions of local police officers. This was the rationale that federal prosecutors used in the Rodney King beating case to bring civil rights charges against the four LAPD officers who beat King. The crucial legal point was that they acted in an official capacity when they violated King's rights. But that's still a high bar to prove.
And the Justice Department time and again has made it clear that they are only a "backstop" to local prosecutors. This means that they rigidly adhere to the legal doctrine of separation of federal and state powers. The killing of Brown, as all potential criminal cases, was first and last a state matter, and the feds scrupulously defer to local authorities to bring charges. If state or county prosecutors won't bring charges or bungle the prosecution when they do, the Justice Department does not regard it as its responsibility to override the decision of local authorities not to retry or second guess a defendant's acquittal. There are two ironclad requisites for a federal prosecution of a police officer for the criminal use of deadly force. One is that there has to be solid proof that the officer acted either with racial animus or with reckless intent to cause malice to an individual. There appears to be no evidence that either was the case with Wilson.
eric holder ferguson justice department michael brown Police Brutality
Black TikTokers Critical of the Lack of Media Attention On Lauren Smith-Fields Who Was Found Dead After a Bumble Date
Rashad Grove
Jay-Z and Meek Mill Support Bill to End Rap Lyrics From Being Used as Criminal Evidence
Delta Sigma Theta Sorority, Inc.'s National President Cheryl A. Hickmon Passes Away


2014 FC Sacred Heart Irish Track Team (front row, left to right) – Colin Niemeyer, Chaz Dunn, Yianni Haralabidis, Sean Strasheim, Kathryn Bieker, Libby Dunn, Jade Hill, Kelsi Fouraker, Elizabeth Magdanz, Aly Bangert, Thea Schulenberg. Second row – Nate Bird, Bailey Witt, Ben Mullins, Reggie Johansen, Rachael Keithley, Abby Magdanz, Joshua Froeschl, Cameron Jordan, Haylee Heits, Zavan Kirkendall, Abbey Neddenriep, Lindsay Frederick, Nicole Fiegener. Third row – Bryant Jorn, Logan Mattan, Emerson Keithley, Cameron Barker, Keith Salimo, Noah Keller, Bailey Coonce, Maggie Goltz, Logan Scheitel, Sawyer Kean, Austin Malone. Back row – Jarod Fiegener, Robert Olberding, Austin Ahern, Megan Strasheim, Juliana Rust, Taylor Coonce. Not pictured Rachel Parrish and Henry Arnold. Photo by Jim Langan.
Sacred Heart's boys track team continued their strong start to the season last Tuesday as they cruised to a 28-point victory over second place Johnson County Central, 126 to 98, at the Thunderbird Invite in Tecumseh.
Just three days removed from a dominant 40-point victory in the 'B' division of the MUDECAS Meet, the Irish boys claimed their third invitational crown of the season.
First-place finishers included sophomore Henry Arnold in the 400-meter dash (54.7 seconds), senior Chaz Dunn in the 800 (2:11.9), senior Sean Strasheim in the pole vault (12 feet, 6 inches) and senior Jarod Fiegener in the discus (130 feet, 7 inches).
The Irish 400-meter relay team of Dunn, junior Sawyer Kean, junior Austin Malone and senior Yianni Haralabidis captured gold, as did the 1600-meter team of Haralabidis, Malone, Kean and Arnold.
The Lady Irish finished sixth with 48 points and were led individually by first-place finishers, junior Elizabeth Magdanz in the pole vault (7 feet, 6 inches) and sophomore Maggie Goltz in the triple jump (34 feet).
The Irish track teams were at Lewiston today and host their invite next Tuesday at Syracuse.
3200-meter relay – 1. Freeman, 11:23.4.
100-meter hurdles – 1. Pomeranke, LL, 16.6; also, 5. Rachel Parrish, FCSH, 18.4.
100-meter dash – 1. Oneth, LL, 12.4.
400 – 1. Bredvick, Free., 1:06.2; also, 6. Laura Stalder, HTRS, 1:09.6.
3200 – 1. Horn, WW, 13:10.6.
200 – 1. Oneth, LL, 26.3.
800 – 1. Weise, TC, 2:42.6; also, 6. Jade Hill, FCSH, 2:49.6.
300 hurdles – 1. Pomerenke, LL, 49.9.
1600 – 1. Weise, TC, 6:02.9.
400 relay – 1. LL, 53.5; also, 6. FCSH (Elizabeth Magdanz, Haylee Heits, Kathryn Bieker, Parrish), 59.3.
1600 relay – 1. TC, 4:34.5; also, 4. FCSH (Hill, E. Magdanz, Heits, Bieker), 4:55.6.
Long jump – 1. Haynes, Free., 15-10.
Triple jump – 1. Maggie Goltz, FCSH, 34-00; 2. Hill, FCSH, 32-10.
High jump – 1. Hinze, LL, 4-07.
Pole vault – 1. E. Magdanz, FCSH, 7-06; also, 3. Hill, FCSH, 6-06.
Discus – 1. Morton, Cone., 109-02; also, 4. Logan Standerford, HTRS, 94-08; 5. Heits, FCSH, 90-09.
Shot put – 1. Huls, Free., 37-01; also, 3. Standerford, HTRS, 35-01; 4. Heits, FCSH, 34-08.
3200-meter relay – 1. JCC, 9:01.3; also, 5. HTRS, 9:46.1.
110-meter hurdles – 1. Nielsen, NCL; also, 3. Colin Niemeyer, FCSH, 17.0.
100-meter dash – 1. Zimmerman, Free., 11.0; also, 3. Yianni Haralabidis, FCSH, 11.1.
400 – 1. Henry Arnold, FCSH, 54.7.
3200 – 1. Salvidar, JCC, 11:05.8; also, 4. Emerson Keithley, FCSH, 12:00.3.
200 – 1. Baden, LL, 23.0; also, 3. Haralabidis, FCSH, 23.4; 5. Arnold, FCSH, 23.9.
800 – 1. Chaz Dunn, FCSH, 2:11.9; also, 5. Noah Sherman, HTRS, 2:18.8.
300-meter hurdles – 1. Kouma, LL, 43.7; also, 3. Niemeyer, FCSH, 47.2; 5. Zavan Kirkendall, FCSH, 47.6.
1600 – 1. Volin, LL, 5:08.6.
400 relay – 1. FCSH (Sawyer Kean, Dunn, Austin Malone, Haralabidis), 45.1; also, 6. HTRS, 49.3.
1600 relay – 1. FCSH (Haralabidis, Malone, Kean, Arnold), 3:43.8.
Long jump – 1. Zimmerman, Free., 22-05 1/2; also, 3. Malone, FCSH, 22-02 3/4; 5. Dunn, FCSH, 19-04 1/4.
Triple jump – 1. Zimmerman, Free., 47-01 3/4 (New Meet Record); 2. Malone, FCSH, 42-10 1/2; also, 4. Arnold, FCSH, 39-08.
High jump – 1. Morris, LP, 5-11.
Pole vault – 1. Sean Strasheim, FCSH, 12-06; also, 3. Ben Railsback, HTRS, 11-06; 5. Jacob Railsback, HTRS, 10-00.
Discus – 1. Jarod Fiegener, FCSH, 130-07; 2. Logan Scheitel, FCSH, 127-04; 3. Chase Hain, HTRS, 116-02.
Shot put – 1. Jiskra, TC, 46-06 1/2; also, 3. Fiegener, FCSH, 42-04.


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Latest Senate Midterm Polling Has Democrats Smiling Wide
Rep. Tim Ryan (R-Ohio) is 11 percent ahead of J.D. Vance among likely voters in new polling out of Ohio from Center Street PAC. The polling measures voters' perspectives in the Senate race in which Ryan and Vance, a Trump endorsement recipient, are competing.
Ryan got 49 percent of the support, while Vance — who Ryan's campaign is significantly out-raising — had 38 percent. Overall, 12 percent of likely voters indicated they were undecided. Other metrics also show Ryan's significant campaign advantages: 23 percent of respondents indicated a "somewhat" or "very" unfavorable view of Ryan, but a full 46 percent of what appears to be overall voters held unfavorable perspectives on Vance. In addition, Ryan led in the new Center Street PAC polling among independents by 21 percentage points, with 39 percent of the support compared to just 17 percent for Vance in that group. That's a significant jump over Ryan's July leading margin of 8 percent among independents. As for Vance, just 62 percent of Republicans indicated a favorable view of him in Center Street PAC's August survey, according to the organization.
As Center Street Chief Analytics Officer Dr. Kurt Jetta explained the race, "These results suggest two things: Ryan's early jump in investment has significantly improved his standing with Ohio voters. Ryan still has some work to do in converting marginal voters to full support, but based on the growth we see in Ryan's awareness and favorability, he seems to be effectively executing his plan." These new numbers from Center Street PAC are some of the best seen so far by the Ryan campaign, although the Democratic contender leads throughout recent polling. A Ryan-sponsored poll from late July found him 3 percent ahead of Vance. In other recent Senate polling, there's more good news for Democrats. In Florida polling from a pair of Democratic-leaning groups, Sen. Marco Rubio (R-Fla.) was tied with expected general election challenger Rep. Val Demings (D-Fla.).
One of the swing state Senate races best for Democrats is no doubt in Pennsylvania, where John Fetterman — the Democratic pick and current lieutenant governor of the state — is leading Trump endorsee Mehmet Oz by double-digits in the weighted average from FiveThirtyEight of polling in the race. Voters are less enthusiastic about Oz than they are for Fetterman: a full 68 percent of Fetterman's supporters in recent polling indicated they "enthusiastically" backed him. For Oz, just 35 percent of his supporters shared the same sentiment about their preferred candidate. There was a similar enthusiasm gap in the Georgia Senate race between incumbent Democrat Raphael Warnock and Republican Herschel Walker, another candidate backed by Trump.
As reported on this site, a full 69 percent of Warnock's supporters in Georgia expressed enthusiasm about their candidate, while just 51 percent of Walker's backers said the same regarding the GOP contender. A full 31 percent of Walker's supporters in the Fox poll indicated "reservations" about their support for the Trump-backed candidate. Only 18 percent of Warnock's supporters also indicated so-called reservations in the context of their Senate preference. These numbers — reflecting enthusiasm in both Pennsylvania and Georgia — all come from Fox polling.
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Monga warns BJP-led Center against any attempt to tinker with Article 35-A
Home » Kashmir » Monga warns BJP-led Center against any attempt to tinker with Article 35-A
Says historical events can't be challenged through courts
FAST KASHMIR NEWS DESK
Srinagar, Jul 31: Warning BJP led Center government against any attempt to tinker with Article 35-A, Jammu and Kashmir Pradesh Congress Committee (JKPCC) Vice President and MLC G N Monga today said that historical events can't be challenged through courts.
"Historical events can't be challenged through courts. Historical facts are facts and under which circumstances the political decisions were taken then can't be challenged in courts now," Monga said in a statement to press issued here.
Giving the historical background of Article 35-A, he said, "Article 35A of the constitution empowers J&K legislature to define state's permanent residents and their special rights and privileges. It was added to the constitution through a presidential order of 1954 with the then J&K government's concurrence. Through 1927 and 1932 notifications, Dogra ruler of the princely state of J&K, Maharaja Hari Singh imposed a law that defined state subjects and their rights. The law also regulated migrants to the state. J&K joined India through instrument of accession signed by its ruler Hari Singh in October 1947."
"After J&K's accession, late Sheikh Mohammad Abdullah took over reins from Dogra ruler and in 1949 he negotiated J&K's political relationship with New Delhi, which led to the inclusion of Article 370 in the Constitution. Article 370 guarantees special status to J&K, restricting Union's legislative powers over three areas: defence, foreign affairs and communications. However, under the 1952 Delhi Agreement between Abdullah and Nehru, several provisions of the Constitution were extended to J&K via presidential order in 1954. Article 35A was inserted then," the Congress leader said.
Asserting that Jammu and Kashmir's accession with India was full and final, Monga said, "By raking up such issues BJP and RSS are trying to challenge it now and they will be themselves responsible for making question mark on accession of the State with the Union."
He said that nobody would be allowed to touch the Article 370. "It was a political issue settled long ago. For electoral gains the BJP is trying to twist the historical facts. Not only people of Kashmir region, but people of Jammu and Ladakh regions too will resist any move by the Center to revoke Article 35-A tooth and nail as it is equally beneficial for the people of all the regions of the state," the Congress leader asserted.


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TikTok: The Updated Statistics
by Julia | Dec 4, 2020 | TikTok news
Arguably one of the hottest brands in social media, TikTok continues to outpace its competitors.
Known for funny skits and dance challenges, TikTok is also evolving into a promotional tool for businesses and marketers. While some of the user-generated content can be cringe-worthy, it can also be addictive.
In case you seriously never heard of the popular video-sharing app, TikTok allows users to create short videos, typically ranging from 15-60 seconds, with music, filters, and additional editing tools. The app was created by Chinese tech giant ByteDance, who originally sold a 12.5% stake in their U.S. business to Oracle and Walmart to avoid being shut down after national security concerns. Since then, it's been reported that ByteDance will be divested of all of its shares (The Verge, 2020).
Let's take a look at some interesting TikTok statistics.
1. Over 850 million active users worldwide
Yes, you read that correctly. According to Wallaroo Media, TikTok has an estimated 850 million active users worldwide, making it more popular than LinkedIn, Twitter, Snapchat, and Pinterest. In response to a lawsuit, TikTok announced having 100 million active U.S. users.
2. Over 2 billion downloads
TikTok statistics show no sign of slowing down. In fact, SensorTower reports that the TikTok app has been downloaded more than 2 billion times globally in the App Store and Google Play.
3. More Than 50 Minutes per Day
People aren't just downloading the app; they are also using it. Users average more than 52 minutes per day on the app, according to Business of Apps.
4. More women users
According to Influencer Marketing Hub, TikTok is used by 2 million more women (8.2 million) than men (6.1 million) in the U.S.
5. Social Media Engagement Rates
In an analysis of 100K influencer profiles, Influencer Marketing Hub found that TikTok has higher follower engagement rates than Instagram and Twitter.
6. TikTok in-app spending soars
Where there is a platform with millions of active users, revenue generation is not far behind. In fact, SpendMeNot reports that TikTok in-app spending increased by 588% in 2019 and SensorTower estimates that TikTok has brought in $75 million from in app purchases from the App Store and Google Play. One source estimates the app will bring in $500 million in 2020 from the U.S. alone.
7. Brands aren't producing the most content
Given the popularity and success TikTok statistics have shown, it is a little surprising that bigger brands are not embracing the platform in larger numbers. Instead, according to SpendMeNot, when it comes to TikTok content, brands are only responsible for 3.7%, while regular users make up 50%, and celebrities/influencers make up 46.9%.
8. TikTok popularity growing among adults
Although TikTok remains more popular with teens, reports are beginning to show increased popularity with adults. MarketingCharts has been tracking the year-over-year growth and reports that in March 2020, the app had more than 28.8 million US adult users. That's an impressive 14 million increase from March the prior year.
9. TikTok will face tough competition in the years ahead
As to be expected, other social media platforms have taken note of TikTok's success. In particular Facebook. No stranger to cloning other social media apps, Facebook rolled out Instagram Reels in an effort to compete with TikTok.
TikTok statistics make it clear. The video-sharing app is here to stay. It comes with a growing and loyal fan base. Whether it's for fun or for business, TikTok is a platform that will allow you to reach large and engaged audiences organically.


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Global shipping is about to be carbon-free
Home Sea Freight Global shipping is about to be carbon-free
April 24, 2018 Sea Freight, Shipping Articles, Sidoman Blog	2 comments	by sidoman
A cargo ship releasing CO2 emissions (Photo courtesy of www.mfame.guru)
The supply chain in the logistics industry has always been plagued by green issues. Although international shipping is already by far the most eco-friendly mode of commercial transport, it is a well-known fact that CO2 emissions from the industry as a whole, which makes up about 3 percent of all global emissions, have been a source of real worry for years now.
For the longest time, supply chain professionals have tried to prioritize green shipping not only because going green is more profitable, but also because a carbon-free shipping industry is certainly the future. The truth is that there was never a single revolutionary idea put in place to turn the shipping industry green- until now.
On Friday 13th, 2018, the International Maritime Organization's Marine Environment Protection Committee (MEPC) agreed for the first time to reduce greenhouse gas emissions from global shipping during the 72nd session held at the company headquarters. The landmark deal was signed at a meeting held at the United Nations International Maritime Organization (IMO) in London. The participants agreed to adopt the first in a long line of strategies to reduce greenhouse gas emissions from ships.
The MEPC meets adopt revised G8 Guidelines (Photo courtesy of www.safety4sea.com)
The end goal is to decrease GHG emissions from international shipping and completely phase GHG emissions out as quickly and as effortlessly as possible in this century. The plan, according to the levels of ambition identified by the participants, is to considerably reduce annual GHG emissions by at least 50% by 2050 compared to 2008, while, concurrently, exploring different avenues that can phase them out completely.
Until this initial strategy was formulated, the shipping industry is the only sector that did not have a comprehensive climate change plan in place. Cargo ships have played an instrumental role in growing today's contemporary global economy; about 90 percent of everything that we buy is transported by cargo ships at one point or another. Without them, the economy would not be as vibrant as it is now.
However, despite their utmost importance cargo ships also burn fossil fuels, which contribute considerably to shifting climate patterns and accelerated global warming. Sadly, many cargo ships still rely on "bunker fuel" to operate, which is basically a cheap blend of petroleum that allows cargo ships to transport goods across the continent for next to nothing.
The shipping industry's continued reliance on high-carbon fuel such as bunker fuel poses a major challenge for all those advocating for a carbon-free future. This new deal advocating for clean shipping will not only help to address the prevalent disinclination to take up meaningful change, but it will also help to set the ball rolling so that advocates of clean shipping can start to ramp up investments into projects that use cleaner technologies that are less debilitating for the ecosystem.
If things continue to remain unchanged, the International Maritime Organization (IMO), which is the shipping industry's main regulator, predicts that carbon emissions from shipping could increase drastically by as much as 250 percent by 2050 as the world's population continues to grow and as global economies keep expanding. At this point, the European Parliament estimates the industry could produce 17 percent of global emissions, up from less than 3 percent today.
For shipping to play its part in combating climate change, all the players in the supply chain need to unite so that global shipping can be radically redesigned so that we can enjoy a carbon-free future in a few decades' time. Delivering on the promise to decrease GHG emissions from international shipping, however, is easier said than done.
Tags: Bunker Fuel Carbon emissions Carbon-free future cargo ships Fossil Fuels GHG emissions from international shipping Global shipping The International Maritime Organization's Marine Environment Protection Committee (MEPC) The Supply Chain
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The Putin System
Politics / history, putin, vladimir, personal, russia, investigative, covering, singlemindedly, played, major, present
Russia's re-emergence on the world stage in recent months is reminiscent of the glory days of the Soviet Union. But, with democratic opposition in the country being systematically crushed, does Vladimir Putin's ultra-authoritarian leadership have more in common with his communist predecessors than previously thought?This film is an investigative documentary covering 30 years in the history of Russia through the personal history of Vladimir Putin: a man who has single-mindedly played all the rules of the game to reach the throne of power. It covers all the major events and aspects of the "Putin system" up to the present day.
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The US and the New Middle East
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Israel Greenwald was killed in 1986 by two New York Police detectives known as the "mafia cops," Stephen Caracappa and Louis Eppolito. His body was not found until 2005.
Two highly decorated former detectives who were convicted of serving as assassins for the mob, helping to kill at least eight men in one of the most spectacular police corruption scandals in New York City's history, were sentenced on Friday to life in prison -- for the second time.
Two former police detectives will continue to receive their tax-free disability pensions despite being convicted of serving as assassins for the Mafia.
It is safe to assume that, after 39 years on the federal bench, Judge Jack B.
The criminal case of two retired detectives, Louis J.
In the orchestration of a trial, summations are much like the crescendo -- a chance for the lawyers not only to reprise their major themes, but also to impress the jury, with performances intended to bring the house down.
No one expects a Mafia defector to be Eagle Scout material.