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Articles by Mohamad A. Eloubeidi
Between 2008 and 2019, M. Eloubeidi wrote the following 38 articles about Pancreatic Neoplasms.
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1 Guideline The role of endoscopy in the diagnosis and treatment of cystic pancreatic neoplasms. 2016
Anonymous6580868 / Muthusamy, V Raman / Chandrasekhara, Vinay / Acosta, Ruben D / Bruining, David H / Chathadi, Krishnavel V / Eloubeidi, Mohamad A / Faulx, Ashley L / Fonkalsrud, Lisa / Gurudu, Suryakanth R / Khashab, Mouen A / Kothari, Shivangi / Lightdale, Jenifer R / Pasha, Shabana F / Saltzman, John R / Shaukat, Aasma / Wang, Amy / Yang, Julie / Cash, Brooks D / DeWitt, John M. · ·Gastrointest Endosc · Pubmed #27206409.
2 Guideline The role of endoscopy in the evaluation and management of patients with solid pancreatic neoplasia. 2016
Anonymous1760853 / Eloubeidi, Mohamad A / Decker, G Anton / Chandrasekhara, Vinay / Chathadi, Krishnavel V / Early, Dayna S / Evans, John A / Fanelli, Robert D / Fisher, Deborah A / Foley, Kimberly / Hwang, Joo Ha / Jue, Terry L / Lightdale, Jenifer R / Pasha, Shabana F / Saltzman, John R / Sharaf, Ravi / Shergill, Amandeep K / Cash, Brooks D / DeWitt, John M. · ·Gastrointest Endosc · Pubmed #26706297.
3 Editorial Sampling para-aortic lymph nodes in pancreatic and biliary cancers with EUS-guided FNA: diagnostic, clinical, and therapeutic implications. 2016
El Hajj, Ihab I / Eloubeidi, Mohamad. ·Division of Gastroenterology and Hepatology, Indiana University, Indianapolis, Indiana, USA. · Anniston Digestive Health, Anniston, Alabama, USA. ·Gastrointest Endosc · Pubmed #27530480.
4 Editorial Diagnosis of pancreatic cancer by contrast-harmonic endoscopic ultrasound (EUS): complementary and not competitive with EUS-guided fine-needle aspiration. 2014
Fusaroli, Pietro / Eloubeidi, Mohamad A. ·American University of Beirut Medical Center, Beirut, Lebanon. ·Endoscopy · Pubmed #24740402.
5 Editorial Biliary findings and the neoplastic potential of branch duct intraductal papillary mucinous neoplasm. 2013
Buxbaum, James L / Eloubeidi, Mohamad A. · ·Clin Gastroenterol Hepatol · Pubmed #23395700.
6 Editorial Molecular and clinical markers of pancreas cancer. 2010
Buxbaum, James L / Eloubeidi, Mohamad A. · ·JOP · Pubmed #21068484.
ABSTRACT: Pancreas cancer has the worst prognosis of any solid tumor but is potentially treatable if it is diagnosed at an early stage. Thus there is critical interest in delineating clinical and molecular markers of incipient disease. The currently available biomarker, CA 19-9, has an inadequate sensitivity and specificity to achieve this objective. Diabetes mellitus, tobacco use, and chronic pancreatitis are associated with pancreas cancer. However, screening is currently only recommended in those with hereditary pancreatitis and genetic syndromes which predispose to cancer. Ongoing work to identify early markers of pancreas cancer consists of high throughput discovery methods including gene arrays and proteomics as well as hypothesis driven methods. While several promising candidates have been identified none has yet been convincingly proven to be better than CA 19-9. New methods including endoscopic ultrasound are improving detection of pancreas cancer and are being used to acquire tissue for biomarker discovery.
7 Review Diagnostic yield of EUS-guided FNA for malignant biliary stricture: a systematic review and meta-analysis. 2016
Sadeghi, Anahita / Mohamadnejad, Mehdi / Islami, Farhad / Keshtkar, Abbas / Biglari, Mohammad / Malekzadeh, Reza / Eloubeidi, Mohamad A. ·Liver and Pancreatobiliary Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. · American Cancer Society, Atlanta, Georgia, USA. · Anniston Digestive Health, Anniston, Alabama, USA. ·Gastrointest Endosc · Pubmed #26422979.
ABSTRACT: BACKGROUND AND AIMS: EUS-guided FNA (EUS-FNA) is increasingly being used for tissue diagnosis of extrahepatic biliary strictures. The aim of this study was to determine the diagnostic yield of EUS-FNA in malignant biliary strictures. METHODS: A comprehensive literature review was carried out by 2 reviewers for studies evaluating the accuracy of EUS-FNA in biliary stricture. A meta-analysis was performed to determine the pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratio for EUS-FNA of extrahepatic biliary stricture. A Quality Assessment of Diagnostic Accuracy Studies questionnaire was used to assess the quality of the selected studies. Several sensitivity analyses were performed to assess the effect of the quality of the studies on the accuracy of the final results of the meta-analysis. RESULTS: Twenty studies involving 957 patients met inclusion criteria and were included in the meta-analysis. The pooled sensitivity and specificity of EUS-FNA for diagnosis of malignant biliary stricture were 80% (95% confidence interval [CI], 74%-86%), and 97% (95% CI, 94%-99%), respectively. The pooled positive likelihood ratio was 12.35 (95% CI, 7.37-20.72), and the negative likelihood ratio was 0.26 (95% CI, 0.18-0.38). The pooled diagnostic odds ratio for diagnosing a malignant biliary stricture was 70.53 (95% CI, 38.62-128.82). The area under the receiver-operating characteristic curve was 0.97. Sensitivity analyses showed that the quality of the included studies did not affect the accuracy of the final results of the meta-analysis. CONCLUSION: This meta-analysis demonstrates that EUS-FNA is sensitive and highly specific for diagnosing malignancy in biliary strictures. Further studies are needed to compare EUS--FNA with emerging methods including cholangioscopy-guided biopsy and laser endomicroscopy.
8 Review Cystsic lesions of the pancreas. 2013
Mohamadnejad, Mehdi / Eloubeidi, Mohamad A. ·Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. ·Arch Iran Med · Pubmed #23496368.
ABSTRACT: Pancreatic cysts (PCs) are being increasingly detected due to the widespread use of high-resolution abdominal imaging. The main imaging modalities to diagnose PCs include high-resolution spiral CT scan, MRI, and endoscopic ultrasound (EUS). EUS has the added benefit of enabling cyst fluid sampling through FNA and significantly improves clinical diagnosis of PCs. Some PCs like pseudocysts, serous cystadenomas, and lymphoepethelial cysts are entirely benign lesions and can be managed non-operatively. However, other lesions like mucinous cystic neoplasms, or cystic neuroendocrine tumors are pre-malignant or malignant lesions and require surgical intervention. In this review, we describe diagnosis and management of common pancreatic cystic lesions.
9 Review How good is endoscopic ultrasound-guided fine-needle aspiration in diagnosing the correct etiology for a solid pancreatic mass?: A meta-analysis and systematic review. 2013
Puli, Srinivas R / Bechtold, Matthew L / Buxbaum, James L / Eloubeidi, Mohamad A. ·Division of Gastroenterology and Hepatology, Massachusetts General Hospital and Brigham Women's Hospital, Harvard School of Medicine, Boston, MA, USA. srinivaspuli@yahoo.com ·Pancreas · Pubmed #23254913.
ABSTRACT: OBJECTIVES: The objective of this study was to evaluate the accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in diagnosing the correct etiology for a solid pancreatic mass. METHOD: Data extracted from EUS-FNA studies with a criterion standard (either confirmed by surgery or appropriate follow-up) were selected. Articles were searched in MEDLINE, CINAHL, and Cochrane Central Register of Controlled Trials & Database of Systematic Reviews. Pooling was conducted by both fixed- and random-effects models. RESULTS: Initial search identified 3610 reference articles, of these 360 relevant articles were selected and reviewed. Data were extracted from 41 studies (N = 4766) which met the inclusion criteria. Pooled sensitivity of EUS-FNA in diagnosing the correct etiology for solid pancreatic mass was 86.8% (95% confidence interval [CI], 85.5-87.9). Endoscopic ultrasound-guided FNA had a pooled specificity of 95.8% (95% CI, 94.6-96.7). Positive likelihood ratio of EUS was 15.2 (95% CI, 8.5-27.3), and the negative likelihood ratio was 0.17 (95% CI, 0.13-0.21). CONCLUSIONS: Endoscopic ultrasound-guided FNA is an excellent diagnostic tool to detect the correct etiology for solid pancreatic masses. When available, EUS-FNA should be strongly considered as the first diagnostic tool for sampling these lesions to optimize patient management.
10 Review Pancreatico-biliary endoscopic ultrasound: a systematic review of the levels of evidence, performance and outcomes. 2012
Fusaroli, Pietro / Kypraios, Dimitrios / Caletti, Giancarlo / Eloubeidi, Mohamad A. ·Department of Clinical Medicine, University of Bologna, 40100 Bologna, Italy. pietro.fusaroli@unibo.it ·World J Gastroenterol · Pubmed #22969187.
ABSTRACT: Our aim was to record pancreaticobiliary endoscopic ultrasound (EUS) literature of the past 3 decades and evaluate its role based on a critical appraisal of published studies according to levels of evidence (LE). Original research articles (randomized controlled trials, prospective and retrospective studies), meta-analyses, reviews and surveys pertinent to gastrointestinal EUS were included. All articles published until September 2011 were retrieved from PubMed and classified according to specific disease entities, anatomical subdivisions and therapeutic applications of EUS. The North of England evidence-based guidelines were used to determine LE. A total of 1089 pertinent articles were reviewed. Published research focused primarily on solid pancreatic neoplasms, followed by disorders of the extrahepatic biliary tree, pancreatic cystic lesions, therapeutic-interventional EUS, chronic and acute pancreatitis. A uniform observation in all six categories of articles was the predominance of LE III studies followed by LE IV, II b, II a, I b and I a, in descending order. EUS remains the most accurate method for detecting small (< 3 cm) pancreatic tumors, ampullary neoplasms and small (< 4 mm) bile duct stones, and the best test to define vascular invasion in pancreatic and peri-ampullary neoplasms. Detailed EUS imaging, along with biochemical and molecular cyst fluid analysis, improve the differentiation of pancreatic cysts and help predict their malignant potential. Early diagnosis of chronic pancreatitis appears feasible and reliable. Novel imaging techniques (contrast-enhanced EUS, elastography) seem promising for the evaluation of pancreatic cancer and autoimmune pancreatitis. Therapeutic applications currently involve pancreaticobiliary drainage and targeted fine needle injection-guided antitumor therapy. Despite the ongoing development of extra-corporeal imaging modalities, such as computed tomography, magnetic resonance imaging, and positron emission tomography, EUS still holds a leading role in the investigation of the pancreaticobiliary area. The major challenge of EUS evolution is its expanding therapeutic potential towards an effective and minimally invasive management of complex pancreaticobiliary disorders.
11 Review The role of endoscopic ultrasonography in the evaluation of pancreatico-biliary cancer. 2010
Varadarajulu, Shyam / Eloubeidi, Mohamad A. ·Department of Gastroenterology and Hepatology and the Pancreatico-biliary Center, the University of Alabama at Birmingham, 1530 3rd Avenue, South - ZRB 636, Birmingham, AL 35294-0007, USA. ·Surg Clin North Am · Pubmed #20362785.
ABSTRACT: Accurate staging of pancreatico-biliary cancer is essential for surgical planning and for identification of locally advanced and metastatic disease that is incurable by surgery. The complex regional anatomy of the pancreatico-biliary system makes histologic diagnosis of malignancy at this region difficult. The ability to position the endoscopic ultrasound transducer at endoscopy in direct proximity to the pancreas and the bile duct, combined with the use of fine-needle aspiration, enables accurate preoperative staging of cancer, especially cancer too small to be characterized by CT or MRI. Endoscopic ultrasonography (EUS) identifies patients unlikely to be cured by surgery due to vascular invasion or regional nodal metastasis, thereby limiting procedure-related morbidity and mortality. This article focuses on the utility and recent advances of EUS in the evaluation of pancreatico-biliary cancer.
12 Review Interventional EUS for the diagnosis and treatment of locally advanced pancreatic cancer. 2010
Al-Haddad, Mohammad / Eloubeidi, Mohamad A. ·Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. ·JOP · Pubmed #20065544.
ABSTRACT: Endoscopic ultrasound (EUS) evolved as the diagnostic test of choice evaluating suspected pancreatic tumors. Coupled with fine needle aspiration (FNA), EUS provides high accuracy for the diagnosis and staging of pancreatic cancer. Novel EUS based techniques have emerged as a safe minimally invasive alternative to the surgical or radiological approaches. By allowing better pain control, delivering antitumor therapies or draining obstructed bile ducts, such techniques hold a big promise to improve the quality of life of patients with unresectable pancreatic cancer. In this review, we will discuss the role EUS-FNA plays in the diagnosis, staging and treatment of patients with locally advanced pancreatic cancer.
13 Clinical Trial A phase I study evaluating the role of the anti-epidermal growth factor receptor (EGFR) antibody cetuximab as a radiosensitizer with chemoradiation for locally advanced pancreatic cancer. 2011
Arnoletti, J P / Frolov, A / Eloubeidi, M / Keene, K / Posey, J / Wood, T / Greeno, Edward / Jhala, N / Varadarajulu, S / Russo, S / Christein, J / Oster, R / Buchsbaum, D J / Vickers, S M. ·Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. ·Cancer Chemother Pharmacol · Pubmed #20589377.
ABSTRACT: PURPOSE: (1) To determine the safety of the epidermal growth factor receptor (EGFR) antibody cetuximab with concurrent gemcitabine and abdominal radiation in the treatment of patients with locally advanced adenocarcinoma of the pancreas. (2) To evaluate the feasibility of pancreatic cancer cell epithelial-mesenchymal transition (EMT) molecular profiling as a potential predictor of response to anti-EGFR treatment. METHODS: Patients with non-metastatic, locally advanced pancreatic cancer were treated in this dose escalation study with gemcitabine (0-300 mg/m(2)/week) given concurrently with cetuximab (400 mg/m(2) loading dose, 250 mg/m(2) weekly maintenance dose) and abdominal irradiation (50.4 Gy). Expression of E-cadherin and vimentin was assessed by immunohistochemistry in diagnostic endoscopic ultrasound fine-needle aspiration (EUS-FNA) specimens. RESULTS: Sixteen patients were enrolled in 4 treatment cohorts with escalating doses of gemcitabine. Incidence of grade 1-2 adverse events was 96%, and incidence of 3-4 adverse events was 9%. There were no treatment-related mortalities. Two patients who exhibited favorable treatment response underwent surgical exploration and were intraoperatively confirmed to have unresectable tumors. Median overall survival was 10.5 months. Pancreatic cancer cell expression of E-cadherin and vimentin was successfully determined in EUS-FNA specimens from 4 patients. CONCLUSIONS: Cetuximab can be safely administered with abdominal radiation and concurrent gemcitabine (up to 300 mg/m(2)/week) in patients with locally advanced adenocarcinoma of the pancreas. This combined therapy modality exhibited limited activity. Diagnostic EUS-FNA specimens could be analyzed for molecular markers of EMT in a minority of patients with pancreatic cancer.
14 Article Endoscopic Ultrasound Assessment of Pancreatic Duct Diameter Predicts Neuroendocrine Tumors and Other Pancreas Masses. 2019
Gupta, Nikhil / Kankotia, Ravi / Sahakian, Ara / Jayaram, Preeth / Shindel, Alex / Dong, Elizabeth / Korc, Paul / Eloubeidi, Mohamad / Buxbaum, James. ·Division of Gastroenterology, Department of Medicine, Kaiser Permanente Los Angeles, Los Angeles. · Department of Medicine, Division of Gastroenterology, Hoag Hospital, Newport Beach, CA. · Department of Medicine, Division of Gastroenterology, Northeast Alabama Regional Medical Center, Anniston, AL. ·Pancreas · Pubmed #30451795.
ABSTRACT: OBJECTIVES: Distinguishing neuroendocrine tumors (NETs) and other pancreas lesions from adenocarcinomas via endoscopic ultrasound (EUS) requires additional tissue for special staining and processing. Our aim was to determine if main pancreatic duct (PD) diameter on EUS helps to differentiate NET and other unusual tumors from adenocarcinoma. METHODS: We evaluated 30 consecutive patients diagnosed with NET or other pancreas lesions by EUS with 90 matched patients who were found to have adenocarcinoma. Dilated PD was defined as greater than 3 mm. Multivariate logistic regression was used to evaluate associations between lesion type and PD diameter. RESULTS: Among the 30 patients with NET/other pancreas lesions, 21 had NETs, 7 had metastases, and 2 had lymphomas. A dilated PD was demonstrated in only 3.3% of pancreatic NET/other lesions but present in 88.9% of cases of primary adenocarcinoma (P < 0.01). In multivariate analysis, a normal PD diameter and absence of clinical symptoms strongly predicted the presence of pancreatic NET/other versus adenocarcinoma (P < 0.01). CONCLUSIONS: The absence of PD dilation upstream of the lesion suggests NET or other lesions rather than adenocarcinoma. This finding should prompt endosonographers to obtain additional tissue at the time of EUS to send for special studies.
15 Article Primary pancreatic Hodgkin's lymphoma diagnosed on EUS-guided FNA. 2016
Mohamadnejad, Mehdi / Khosravi, Pejman / Khani, Mohsen / Nikmanesh, Arash / Eloubeidi, Mohamad A. ·Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. · Division of Pathology, Tehran Gastroenterology and Hepatology Center, Tehran, Iran. · Department of Medicine, Division of Gastroenterology, American University of Beirut, Beirut, Lebanon. ·Gastrointest Endosc · Pubmed #26422973.
16 Article Lymph node ratio is an independent prognostic factor after resection of periampullary malignancies: data from a tertiary referral center in the middle East. 2014
Shamseddine, Ali I / Mukherji, Deborah / Melki, Christian / Elias, Elias / Eloubeidi, Mohammad / Dimassi, Hani / Khalife, Mohammad / Abou-Alfa, Ghassan / O'Reilly, Eileen / Faraj, Walid. ·*Department of Internal Medicine, Division of Hematology and Oncology †Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery ‡Department of Internal Medicine, Division of Gastroenterology, American University of Beirut, Beirut §Lebanese American University, School of Pharmacy, Byblos, Lebanon ∥Memorial Sloan-Kettering Cancer Center, Section of Gastrointestinal Oncology, New York, NY. ·Am J Clin Oncol · Pubmed #23111358.
ABSTRACT: OBJECTIVE: The prognostic impact of nodal involvement in resected pancreatic carcinoma and biliary malignancy has been relatively well established. It has been suggested that lymph node ratio (LNR) may be a more informative way of stratifying patients with node positive disease. Our retrospective review aimed to investigate the significance of such variables and test for independent prognostic factors for survival. METHODS: One hundred eighty-three pancreatic and periampullary malignancy cases were registered at the American University of Beirut Medical Center from 1990 to 2004. Of those, 80 had complete data on lymph node status. We analyzed the impact of the number of lymph nodes resected, the number of positive lymph nodes retrieved and LNR using Kaplan-Meier and Cox proportional hazard models. The measured outcome in the KM model was the survival probability at 1, 3, and 5 years while the Cox model was used to measure the hazard ratio (HR) of the previously identified predictors on survival. RESULTS: For the 80 patients included in this analysis, overall survival rates were 65% (54 to 78), 32% (18 to 47), and 21% (8 to 34) were alive at 1, 3, and 5 years, respectively. The median number of resected lymph nodes was 9. In the node positive patients, those who had >12 nodes examined were found to have a significantly better survival (HR=0.24; P=0.013). On multivariate analysis, our model showed the following factors to be significant: age 60 years or older (HR=5.92; P=0.018), poorly differentiated tumors (HR=21.87; P=0.018), number of lymph nodes examined <12 LN (HR=6.77; P=0.022), 3 or more metastatic LN (HR=7.21; P=0.028), and LNR≥0.2 (HR=7.12; P=0.007). CONCLUSIONS: After pancreaticodudonectomy for adenocarcinoma of the pancreas and biliary malignancies, ratio-based lymph node staging is an independent and powerful prognostic factor.
17 Article The presence of a cytopathologist increases the diagnostic accuracy of endoscopic ultrasound-guided fine needle aspiration cytology for pancreatic adenocarcinoma: a meta-analysis. 2013
Hébert-Magee, S / Bae, S / Varadarajulu, S / Ramesh, J / Frost, A R / Eloubeidi, M A / Eltoum, I A. ·Division of Anatomic Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249-6823, USA. shebertm@uab.edu ·Cytopathology · Pubmed #23711182.
ABSTRACT: OBJECTIVE: A meta-analysis has not been previously performed to evaluate critically the diagnostic accuracy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of solely pancreatic ductal adenocarcinoma and address factors that have an impact on variability of accuracy. The aim of this study was to determine whether the presence of a cytopathologist, variability of the reference standard and other sources of heterogeneity significantly impacts diagnostic accuracy. METHODS: We conducted a comprehensive search to identify studies, in which the pooled sensitivity, specificity, likelihood ratios for a positive or negative test (LR+, LR-) and summary receiver-operating curves (SROC) could be determined for EUS-FNA of the pancreas for ductal adenocarcinoma using clinical follow-up, and/or surgical biopsy or excision as the reference standard. RESULTS: We included 34 distinct studies (3644 patients) in which EUS-FNA for a solid pancreatic mass was evaluated. The pooled sensitivity and specificity for EUS-FNA for pancreatic ductal adenocarcinoma was 88.6% [95% confidence interval (CI): 87.2-89.9] and 99.3% (95% CI: 98.7-99.7), respectively. The LR+ and LR- were 33.46 (95% CI: 20.76-53.91) and 0.11 (95% CI: 0.08-0.16), respectively. The meta-regression model showed rapid on-site evaluation (ROSE) (P = 0.001) remained a significant determinant of EUS-FNA accuracy after correcting for study population number and reference standard. CONCLUSION: EUS-FNA is an effective modality for diagnosing pancreatic ductal adencarcinoma in solid pancreatic lesions, with an increased diagnostic accuracy when using on-site cytopathology evaluation.
18 Article Endosonographic and cyst fluid characteristics of cystic pancreatic neuroendocrine tumours: a multicentre case series. 2013
Ho, Henry C / Eloubeidi, Mohamad A / Siddiqui, Uzma D / Brugge, William R / Rossi, Federico / Bounds, Brenna W / Aslanian, Harry R. ·Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA. Electronic address: henry.ho@yale.edu. ·Dig Liver Dis · Pubmed #23582348.
ABSTRACT: BACKGROUND: Pancreatic neuroendocrine tumours are uncommon neoplasms which may rarely be cystic. Differentiation from other more common cystic neoplasms may be difficult. AIMS: To describe the morphologic, cytologic, and cyst fluid characteristics of cystic pancreatic neuroendocrine tumours. METHODS: Retrospective analysis of consecutive patients referred for endosonographic evaluation of pancreatic cysts at four centres. RESULTS: 27 patients (12 males) with cystic pancreatic neuroendocrine tumours were identified. Prior to endosonography, this tumour was suspected in only 2 patients based on presenting symptoms (7.4%). The median cyst size was 35 mm (range 8-80 mm). Wall thickening was identified in 13 cases. The median carcinoembryonic antigen level was 1.25 (range 0.6-500). Fine needle aspiration cytology in 17 of 24 patients confirmed neuroendocrine tumour (71%). In 8 of 9 patients who had needle targeting of the cyst wall, cytology was consistent with neuroendocrine tumour (88.9%). 18 patients underwent surgical resection. CONCLUSIONS: Cystic pancreatic neuroendocrine tumour was rarely suspected, including by cross-sectional imaging. Wall thickening was identified in approximately half of cases on endosonography. Cyst fluid was typically non-viscous with very low carcinoembryonic antigen levels. Targeting the wall during fine needle aspiration had a high diagnostic yield and should be performed.
19 Article Intrapapillary mucinous tumor of the pancreas (with video). 2013
El Majzoub, Nadim W / Eloubeidi, Mohamad A. ·Department of Internal Medicine and the Division of Gastroenterology and Hepatology, The American University of Beirut Medical Center, Beirut, Lebanon. ·Gastrointest Endosc · Pubmed #23347751.
20 Article Patients with obstructive jaundice and biliary stricture ± mass lesion on imaging: prevalence of malignancy and potential role of EUS-FNA. 2013
Tummala, Pavan / Munigala, Satish / Eloubeidi, Mohamad A / Agarwal, Banke. ·Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO 63110, USA. ·J Clin Gastroenterol · Pubmed #23340062.
ABSTRACT: BACKGROUND: In patients with obstructive jaundice and biliary stricture, the role of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is debated for fear of missing a potentially resectable pancreatobiliary malignancy (PBM). We evaluated the prevalence of (1) PBM; (2) lesions that do not require a potentially curative cancer surgery; and (3) potentially resectable PBMs in patients with false-negative diagnosis by EUS-FNA. PATIENTS AND METHODS: This is a retrospective analysis of 342 patients who underwent EUS/EUS-FNA from 2002 to 2009 after presenting with obstructive jaundice and a biliary stricture. Of these, 170 patients had no definitive mass on computed tomography and 172 patients had definitive mass on computed tomography without evidence of unresectability. Final diagnosis was based on surgical pathology or definitive cytology and clinical follow-up of ≥ 12 months. RESULTS: The mean age of patients (176 male) was 68.0±12.5 years. A final diagnosis of malignancy was made in only 248 patients (72.5%; 95% confidence interval, 67.7, 77.2). The overall accuracy of EUS-FNA for diagnosing malignancy was 92.4% (89.0, 94.8), with 91.5% sensitivity (87.1, 94.5) and 80.9% negative predictive value (72.0, 87.5). Among 21 patients with false-negative diagnosis, 8 had cholangiocarcinoma (2 resectable), 13 had pancreatic cancer (5 resectable). EUS-FNA provided information to potentially modify surgical management in 116 patients (33.9%; 95% confidence interval, 29.1, 39.0): 89 patients diagnosed as true negatives, 24 with distant malignant lymphadenopathy, and 3 with malignant lymphoma. CONCLUSIONS: In above-defined patient subset, the risk of missing resectable tumors by EUS-FNA has been exaggerated because of artifactually low negative predictive value resulting from a high pretest probability of PBM. The actual miss rate for resectable PBM by EUS-FNA is rather small and was 2% in present cohort. Information from EUS-FNA can potentially modify surgical management in up to one third of patients.
21 Article Ratio of pancreatic duct caliber to width of pancreatic gland by endosonography is predictive of pancreatic cancer. 2013
Eloubeidi, Mohamad A / Luz, Leticia P / Tamhane, Ashutosh / Khan, Mahboob / Buxbaum, James L. ·Department of Gastroenterology and Hepatology, University of Alabama in Birmingham, Birmingham, AL, USA. me75@aub.edu.lb ·Pancreas · Pubmed #23271395.
ABSTRACT: OBJECTIVES: This study aimed to determine whether (1) a pancreatic duct (PD) diameter to pancreatic gland width (G) ratio (PDG) by endoscopic ultrasonography (EUS) predicts pancreatic cancer (PC) and (2) whether this ratio better indicates PC compared to PD dilation alone. METHODS: Patients presenting for EUS were classified into the following 4 categories: (1) normal, (2) noncalcific chronic pancreatitis (NCCP), (3) calcific CP (CCP), and (4) PC. RESULTS: There were 198 patients enrolled. Final diagnoses were PC (n = 34), CCP (n = 16), and normal/NCCP (n = 148). The median PD diameter (8, 5, and 2 mm, respectively; P = <0.001), G (16, 20, and 17 mm, respectively; P = 0.002), and PDG ratio were significantly different among groups (0.54, 0.25, and 0.12, respectively; P < 0.001). Patients with PC were more likely to have a PDG ratio of greater than or equal to 0.34 compared to CCP, and normal/NCCP groups (94%, 19%, 1.3%, respectively; P < 0.001). The positive predictive value, negative predictive value, sensitivity, specificity, and accuracy of PDG greater than or equal to 0.34 for detecting cancer were 87%, 99%, 94%, 97%, and 97%, respectively. The accuracy and positive predictive value of PD dilation alone for diagnosing PC were 83% and 50%, respectively. CONCLUSIONS: A PDG ratio is a good predictor of PC and is better than PD dilation. This sign should be routinely used by endosonographers to improve EUS diagnostic capability of PC.
22 Article Utility of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of colorectal carcinoma. 2013
Knight, Carrie S / Eloubeidi, Mohamad A / Crowe, Ralph / Jhala, Nirag C / Jhala, Darshana N / Chhieng, David C / Eltoum, Isam A. ·Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama. ·Diagn Cytopathol · Pubmed #21932358.
ABSTRACT: The objective of this study is to assess the utility of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the diagnosis and staging of colorectal cancer. The study includes patients who underwent EUS-FNA at our institution for staging of colorectal carcinoma or for evaluation peri-rectal masses or distal metastases from August 2000 to November 2010. We assessed the frequency with which EUS-FNA procedure confirms the diagnosis of malignancy and the percent of cases in which it modifies staging of colorectal carcinoma. Using histology as a reference standard, we also assessed the diagnostic performance. We identified 79 cases of EUS-FNA from 77 patients, mean (SD) age of 60 (12.5), 44 males. Twenty-seven (34%) aspirates were from patients with primary rectal/peri-rectal masses, 15 (19%) were from patients with suspected regional lymph node metastasis, and 37 (47%) were cases of suspected of distal metastasis. All lesions were clinically suspicious for primary or metastatic colorectal carcinoma. On cytologic examinations, 43 (54%) cases were confirmed as malignant, 6 (8%) were benign neoplasms, 4 (5%) were suspicious for malignant neoplasm, 2 (3%) showed atypical cells, and the rest 24 (30%) were negative for neoplasms. Fourteen of 27 (52%) of the local rectal masses were confirmed as colorectal carcinoma. Eleven of 15 (73%) regional lymph nodes were positive for metastasis-all, but two of these metastases, were of colorectal origin. Twenty of 37(54%) distal lesions were metastatic neoplasms and 15 of those were colorectal in origin. Diagnosis of primary colorectal carcinoma was confirmed in 52% of the clinically suspicious primary lesions and in 42% regional or distal metastatic lesions. Using histology as a reference standard in 27 of 79 (29%) cases, we calculated an overall sensitivity, specificity, and positive and negative predictive values (C.I) of EUS-FNA of 89% (74-100%), 79% (50-100%) 89% (74-100%), and 79% (51-100%). EUS-FNA is useful for assessing primary and metastatic colorectal lesion. This technique improves staging of suspected nodal or distant metastases.
23 Article Comparison of the influence of plastic and fully covered metal biliary stents on the accuracy of EUS-FNA for the diagnosis of pancreatic cancer. 2012
Siddiqui, Ali A / Fein, Michael / Kowalski, Thomas E / Loren, David E / Eloubeidi, Mohamad A. ·Division of Gastroenterology and Hepatology, Department of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA. ali.siddiqui@jefferson.edu ·Dig Dis Sci · Pubmed #22526586.
ABSTRACT: BACKGROUND AND STUDY AIMS: Prior studies have reported that the presence of prior biliary stent may interfere with EUS visualization of pancreatic tumors. We aimed to compare the influence of the biliary plastic and fully covered self-expanding metal stents (CSEMS) on the accuracy of EUS-FNA cytology in patients with solid pancreatic masses. PATIENTS AND METHODS: We conducted a retrospective study evaluating 677 patients with solid pancreatic head/uncinate lesions and a previous biliary stent in whom EUS-FNA was performed. The patients were stratified into two groups: (1) those with a plastic stents and (2) those with CSEMS. Performance characteristics of EUS-FNA including the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were compared between the two groups. RESULTS: The frequency of obtaining an adequate cytology by EUS-FNA was similar in both the CSEMS group and the plastic stent group (97 vs. 97.1 % respectively; p = 1.0). The sensitivity, specificity, and accuracy of EUS-FNA was not significantly different between patients with CSEMS and plastic stents (96.8, 100, 100 % and 97.3, 98, 99.8 %, respectively). The negative predictive value for EUS-FNA was lower in the CSEMS group compared to the plastic stent group (66.6 vs. 78.1 % respectively; p = 0.42). There was one false-positive cytology in the plastic stent group compared to none in the CSEMS group. CONCLUSIONS: In a retrospective cohort trial, EUS-FNA was found to be highly accurate and safe in diagnosing patients with suspected pancreatic cancer, even in the presence of a plastic or metallic biliary stent. The presence of a stent did not contribute to a higher false-positive cytology rate.
24 Article Oncocytic intraductal papillary mucinous neoplasm with carcinomatous degeneration. 2012
Buxbaum, James L / Jhala, Nirag C / Christein, John D / Eloubeidi, Mohamad A. ·Department of Gastroenterology, the University of Southern California, Los Angeles, California, USA. ·Gastrointest Endosc · Pubmed #22440204.
25 Article Unusual, metastatic, or neuroendocrine tumor of the pancreas: a diagnosis with endoscopic ultrasound-guided fine-needle aspiration and immunohistochemistry. 2012
Eloubeidi, Mohamad A / Tamhane, Ashutosh R / Buxbaum, James L. ·Department of Gastroenterology and Hepatology, University of Alabama in Birmingham, Birmingham Alabama, USA. me75@aub.edu.lb ·Saudi J Gastroenterol · Pubmed #22421714.
ABSTRACT: BACKGROUND/AIM: To determine the yield of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in combination with immunostains in diagnosing unusual solid pancreatic masses (USPM) in comparison with pancreatic adenocarcinoma (ACP). PATIENTS AND METHODS: All EUS-FNA of solid pancreatic masses performed with a 22-gauge needle were included. Data on clinical presentations, mass characteristics, presence of pancreatitis, yield of tissue, and final diagnosis were compared between the two groups. On site cytopathology was provided and additional passes were requested to perform immunostains. RESULTS: Two hundred and twenty-nine cases with either adenocarcinoma or USPM were included. The median age of the cohort was 65 years. ACP (210/229, 92%) accounted for the majority of the cases. The USPM included neuroendocrine (NET) masses (n=13), metastatic renal carcinoma (n=3), metastatic melanoma (n=1), lymphoma (n=1), and malignant fibrous histiocytoma (n=1). Subjects with ACP were significantly more likely to present with loss of weight (P=0.02) or obstructive jaundice (P<0.001). Subjects with ACP were more likely to have suspicious/atypical FNA biopsy results as compared with USPM (10% vs 0%). The sensitivity of EUS-FNA with immunostains was 93% in ACP as compared with 100% in USPM. Diagnostic accuracy was higher in USPM as compared with ACP (100% vs 93%). CONCLUSIONS: EUS-FNA using a 22-gauge needle with immunostains has excellent diagnostic yield in patients with USPMs, which is comparable if not superior to the yield in pancreatic adenocarcinoma.


text:
Tattoo is the fourth studio album and fifth album overall  released by Rory Gallagher, in 1973.

Background
Classic Rock magazine opined that Tattoo was an album that "crossed many genres of rock and roll and showcased the writing talents of Rory Gallagher more than any of his previous records." BBC's reviewer noted that while Gallagher "toured constantly," he still "found time away from the stage to write so many great songs," adding that "Tattoo is perhaps the pick of the bunch: a near-perfect document of the powerful, passionate performances that placed Rory in a league of his own."  For the reviewer, the album was "a scintillating showcase for Rory's mastery of his craft" from "the laid back vibe of opener "Tattoo'd Lady," the raunchy riffing of "Cradle Rock" and "Admit It" to quieter moments such as the acoustically driven "20:20 Vision."

"Cradle Rock" was inspired by the "happy coincidence" that Gallagher "rocked literally all his life" having been born at the Rock Hospital in Ballyshannon, Ireland. The track was also covered by Joe Bonamassa on his debut album A New Day Yesterday.

According to Rory's brother, Donal, Polydor did not  "properly promote" the album.

Track listing
All songs composed by Rory Gallagher except where noted.

Side one
"Tattoo'd Lady" – 4:34
"Cradle Rock" – 6:15
"20:20 Vision" – 4:02
"They Don't Make Them Like You Anymore" – 4:05
"Livin' Like a Trucker" – 4:19
Side two
"Sleep on a Clothes Line" – 5:13
"Who's That Coming" – 7:09
"A Million Miles Away" – 6:55
"Admit It" – 4:19
CD bonus track
"Tucson, Arizona" (Link Wray) – 3:47
"Just a Little Bit"  – 7:43 (Rosco Gordon)

Track listing on French LP
 Side 1 : "Tattoo'd Lady" - "They Don't Make..." - "A Million Miles Away" - "Who's That Coming" - "Livin' Like a Trucker"
 Side 2 : "Cradle Rock" - "Admit It" - "20:20 Vision" - "Sleep on a Clothes Line"

Personnel
Rory Gallagher – guitars, vocals, harmonica, saxophone, mandolin, bouzouki
Gerry McAvoy – bass guitar
Lou Martin – keyboards, accordion
Rod de'Ath – drums, percussion
Technical
Carlos Olms – engineer
Robin Sylvester – remixing engineer
Robin Lawrie – cover illustration

References

1973 albums
Rory Gallagher albums
Albums produced by Rory Gallagher
Polydor Records albums

it:Tattoo#Musica

redpajama_set_name: RedPajamaWikipedia


Kerala, a state situated on the tropical Malabar Coast of southwestern India, is one of the most popular tourist destinations in the country. Named as one of the ten paradises of the world byNational Geographic Traveler, Kerala is famous especially for its ecotourism initiatives andbeautiful backwaters.
02 Nights accommodation in Munnar..
01 Night accommodation in Alleppey..
Daily Breakfast at the hotel..
All tours and transfers on private basis as per the itinerary..
Any meals other than those mentioned above..
Any services not specifically mentioned in the inclusions..
Any meals, accommodation or services not mentioned in the itinerary, hotel list or 'includes' list..
It is a beautiful tea town in Idukki district of Kerala easily accessible from Kochi and Coimbatore. The gorgeous hill station is ideally placed in the South Western Ghats of India. With an area of around 557 sq km, Munnar in Devikulam Taluk is the largest panchayat in Kerala.
Alleppey & Kumarakom both are the starting-points of the boat cruises through the backwaters. Whether you choose alleppey or Kumarakom the scenes in the backwaters would be the same. Sailing along in a houseboat through the enchanting backwaters of Alappuzha or Kumarakom is sure to rob your heart.
Once Booking reconfirm it will entertain 100 % cancellation charge..
Revised GST 9 %(w.e.f. 21st Jan'17) will be applicable..
Above rates are not valid for long weekends / festival period..
1 Days (Arrival at Kochi | Munnar ) On Arrival at Kochi Airport/Railway Station you will meet our representative and will be driven to Munnar by private vehicle. Check-in at the hotel and enjoy the rest of the day at leisure. Overnight at the hotel. 2 Days (Munnar) After Breakfast proceed for sightseeing tour of Munnar visiting the Eravikulam National Park, Mattupetty Dam & Dairy Farm, Old Munnar Town and the town market. Post tour return to hotel and enjoy the rest of the day at leisure. Overnight at the hotel. 3 Days (Munnar - Kumarakom/Alleppey) After breakfast check out from the hotel and drive to Kumarakom/Alleppey. On arrival Check-in at the hotel. (Optional Tour - Day Cruise in Alleppey. The same can be booked online while or after booking the package). Overnight at the hotel. 4 Days (Kumarakom/Alleppey - Kochi Airport/Railway Station) After breakfast check out from the hotel and drive to Kochi for transfer to Airport/Railway Station for your onward journey.


text:
JEI est un sigle qui peut désigner :
 jeune entreprise innovante, une PME de moins de 8 ans qui engage des dépenses de recherche-développement représentant au moins 15 % de ses charges ;
 , une revue scientifique à comité de lecture couvrant les sujets technologiques relatifs au domaine de l'imagerie électronique ;
 Jomhuri-ye Eslāmi-ye Irān (en français, république islamique d'Iran).


text:
Things We Can't Ignore
What's the deal with "cockroach milk," and is it really an amazing new superfood?
Jessica Booth
ananaline / Getty Images
At this point, we're all used to hearing about strange new food trends that have taken the health and wellness community by storm. Usually these options seem kind of out there, but harmless at the same time: plant-based meats, sorghum, and charcoal water. But right now, there's an emerging new health trend that has people feeling more than a little freaked out. It's cockroach milk. Seriously. As gross as it sounds, it's hard not to wonder about what exactly cockroach milk is, and if it's really an amazing superfood worth trying.
Cockroach milk is exactly what it sounds like: milk from cockroaches. It's another non-dairy milk option, similar to almond milk or oat milk — it's just that this one comes from bugs, not a harmless nut or grain.
As it turns out, yes, it really is that good for you. While it's unclear if cockroach milk will actually become a *thing,* it definitely should because it's full of health benefits. A 2016 study found that cockroach milk isn't only sustainable, it's also a whole lot more nutritious than dairy milk. Cockroach milk is full of protein. Sanchari Banerjee, one of the main researchers from the Institute for Stem Cell Biology and Regenerative Medicine in India, said that the milk has "proteins, fats, and sugars. If you look into the protein sequences, they have all the essential amino acids." It can supposedly give you three times the amount of energy that the most nutritious dairy milk can give you.
According to The Guardian, cockroach milk tastes similar to cow's milk.
Don't assume you can get this out of any old cockroach you find walking around — this milk can only come from a very specific species of cockroach found in Hawaii. Instead of laying eggs, they give birth to live young and produce a crystalline milk to feed the embryos. That milk can be good for us, too (it's just that extracting it is difficult and tedious). Some say that since the cockroaches die in the process, it's not a great idea. Still, others say it's a better process than the farming of dairy cows. That includes the company Gourmet Grubb, which sells bug milk ice cream.
As horrible as all this seems, it might be a concept you'll have to get used to. Using bugs for our nutrition needs is becoming more popular as scientists realize that the meat industry is having a seriously negative impact on the earth, and that eating bugs is a more nutritious and sustainable way of life.
Still, cockroach milk seems, um, a little too far at this point in time. Maybe it has a better chance in the future?
By Jessica Booth
Reese's is finally making the one change to peanut butter cups that you've always wanted
Your beloved Butterfinger is getting a makeover in 2019, and it actually sounds amazing
These 3 frosé recipes will be the toast of your next boozy summer barbecue
8 sources of vegan protein that will fit easily into your weekly meal plan
The best grocery store wines to buy this weekend if you're a budget booze queen
What a development director in Louisville, Kentucky ate for lunch for a week
This Fourth of July cocktail is like a drinkable firecracker, in a good way
I tried CBD in my tea, and here's what I felt
8 women reveal how they dealt with stinky keto breath
Coca-Cola is releasing a new Coke flavor for the first time in over a decade, and it sounds like a '90s childhood treat
This easy "dessert sushi" recipe will make your tastebuds soy happy
The new Starbucks Frappuccino is basically summer camp in a cup
This is the wine you should drink this weekend, according to your zodiac sign
Starbucks teamed up with Ariana Grande on its latest drink, and it quite literally sounds like heaven
Eating breakfast at diners with my dad is how we say "I love you"
This chocolate hummus recipe is the healthy dessert we didn't know we needed
What a full-time writer in Los Angeles ate for lunch for a week
4 women told us what it was really like to do Dry January, because we had to ask
Disney is selling a Dole Whip Sugar Cookie Sandwich, and it's the perfect boozy summer snack
9 National Pizza Day deals to devour for the best day of 2019
Cockroach Milk
New Foods

redpajama_set_name: RedPajamaCommonCrawl


text:
Corporate Information & Audit
Financial and Programmatic Releases
Annual Report & Year in Review Videos
Community Impact Institute
WorkStar TM Designation
Invest in Us!
The Case for Socially Responsible Investing
Ten years ago, The Fedcap Group launched our first Solution Series—dedicated to addressing issues important to Business in the 21st Century. These sessions have brought together over 2000 representatives from business, academia, foundations, government and advocates.
On Tuesday morning, March 26, from 8-9:30 a.m. at the Westin NY Grand Central Madison Ballroom, The Fedcap Group will be hosting what I believe will be one of our most compelling and topical Solution Series to date: Socially Responsible Investing: The Moral Case for Impact Investing.
As a society, it is clear we can no longer ignore the pressing social, economic, and environmental challenges that threaten the future of our generation and those to come. In my own lifetime, the world's population has grown by billions; our climate has grown warmer and is subject to unpredictable disasters; poverty, starvation, and economic inequity are plagues that affect many more communities than just a short generation ago.
As business leaders, as investors, and as stewards of public funding, it is in our collective best interests to mobilize our capital for the long term public good. This investment approach—known as Socially Responsible Investing—or Impact Investing—provides a vehicle to make a sound and tangible difference.
One socially responsible investment framework that is gaining momentum as a system and as a structure integrates Environmental, Social, and Governance (ESG) considerations into institutional and private investing. ESG evaluates and measures the impact of how a company manages its various resources and the relative risks inherent in business operations—including environmental factors such as water, energy, and air quality, social factors such as diversity and human capital, and governance issues around ethics and integrity.
More and more businesses are investing in socially responsible ventures with favorable returns. Google, for example, invested recently $1billion in renewable energy products. Coca-Cola in investing $1 billion in help support and develop business skills in women and minority-owned suppliers.
On March 26, we will be hearing more about the case for Socially Responsible Investing from three nationally recognized experts at the forefront of this investment framework. I invite you to register for this free forum that will lay out the foundation for the moral, the practical, and the profitable case for Socially Responsible Investing.
I look forward to seeing you there.
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text:
Second & Flume
Chico PD's narrative of an officer's encounter with a coed is questionable
By Melissa Daugherty
The Chico Police Department's narrative of an officer's recent scuffle with a teenage coed raises a number of red flags. CN&R received a three-page press release prepared by Chico Police Chief Mike O'Brien on Monday. The department has been in damage-control mode since video of the incident went viral over the weekend.
The short version of Officer Steve Dyke's account is that he'd noticed a woman taking cellphone video of him assisting another officer with a DUI investigation in the wee hours of Saturday on The Esplanade. Turns out her name is Madeline Hemphill. At one point, Dyke "had to command" her to move out of the street. Dyke then saw a car without a functioning license plate light pull up to where Hemphill was standing. The Chico cop reportedly didn't know whether Hemphill got into the car.
Fast-forward about half an hour. According to O'Brien's statement, Dyke then pulls over a vehicle without an operational light two blocks from that DUI stop. The driver of the vehicle, Nicole Braham, is at the center of the video in question. What the footage shows is Braham cringing and crying out from Dyke's restraining technique.
Hemphill is also at the scene. Based on the chief's report, Dyke recognizes her from their earlier encounter. In the video, she's heard repeatedly asking the mid-30s lawman why he's detaining Braham: "What did she do, officer?" Eventually, Dyke flips the flailing 19-year-old Braham on the ground and sits with his knee in her back. Moments later, at Dyke's command, Hemphill is arrested off camera by other officers who arrive, presumably as back-up. The video is captured by a third woman, who pleads with an unnamed officer that Dyke is "being super aggressive for no reason."
The press release says that Braham and 21-year-old Hemphill (both Chico State students) were arrested for "resisting and delaying a peace officer." It notes that Hemphill had a blood alcohol content (BAC) of .141.
Questions: Why determine Hemphill's BAC? After all, she's of legal drinking age and wasn't driving. Perhaps to undermine her credibility? Does the department have a record of Dyke calling into dispatch his traffic stop on Braham over that inoperable light? She maintains she was never actually pulled over.
Other sketchy stuff: The press release says "Hemphill lost her phone during the arrest." Not true, she says. In an email to CN&R, Hemphill says she was tackled to the ground; her phone immediately confiscated. (Hemphill had been filming Dyke during this incident as well. She even tells him she's doing so.) The next day, after her release from jail, she went to the department to retrieve her iPhone and was reportedly told it was being kept as evidence in her case.
Hemphill says whoever has the device has tampered with it. Her Apple ID log-in has been changed and her Find My iPhone app disabled, according to emailed alerts. She believes the police are claiming the phone is lost because it contains video of them using excessive force.
Given that Hemphill filmed both incidents and Dyke was aware of her doing so, it seems unlikely the phone would simply vanish. In the video, he is clearly annoyed by Hemphill. "Take her to jail," he yells at one point.
The whole fiasco warrants a thorough investigation, including finding out what's on that phone.
More Opinions » Second & Flume
Congressman Doug LaMalfa duped city of Chico into giving him a free venue for one of his many campaign stops.
Welcome back, students, to Chico State's awesome campus.
Much too far
Americans must do what the GOP refuses to do: Reject Donald Trump before it's too late.
Fantasies of moving to the coast interrupted by my love of Chico.
Coffee with the chief
What Chico's top cop is doing in the wake of America's strained relations with law enforcement.


In 1992, a heavy rainstorm caused massive power outage in Hong Kong. At that night, two young astrology enthusiasts, Moon and Sun, met under the starry night by the seaside. When their affection to each other grew, Sun was admitted into a boarding school and would move to another country in a few months under his father's plan.


text:
Q: How to update certain data There is an object in which users are in the form of an array, how to update a user with a specific id, without sending the entire array of users.
const users = firebase.ref().child('users');
users.set(usersArray);

// data is stored in this form
{
  users: [
    {
      id: userId,
      ...
    },
    {
      id: userId,
      ...
    }
  ]
  ...
}

when simultaneously updating the data of different users, the sent data is overwritten, but it is necessary that it is not overwritten

A: You can do using update or set with merge true
set(
  {a: {b: {c: true}}},
  {merge: true}
)
With update you can also use field paths for updating nested values:

update({
  'a.b.c': true
})

ref: Difference between set with {merge: true} and update

redpajama_set_name: RedPajamaStackExchange


text:
Home News Terrorism Iran has a significant role in Sudan's arms industry
Iran has a significant role in Sudan's arms industry
It said that there is "emerging evidence that Iran has played a significant role in supporting Sudan's weapons manufacturing sector".
Khartoum's army spokesman, Sawarmi Khaled Saad, told AFP that many countries, not only Iran, cooperate with Sudan.
There is "nothing peculiar" in Sudan's relations with Iran, Ibrahim Ghandour, the top assistant to President Omar al-Bashir, has said.
"We are not in a military alliance."
China has also reportedly provided training and technical support for Sudanese weapons production, the Small Arms Survey said.
It cited data showing that most of Sudan's imported small arms, light weapons, ammunition, rocket and grenade launchers have come from China in recent years.
But the report also elaborates on the extent of Sudan's military links with Iran, which have repeatedly been the subject of regional concern and speculation.
"Military ties between Iran and Sudan have grown strong over the years," said the Small Arms Survey, a Swiss-based independent research group.
Two Iranian warships made a call last week in Port Sudan, across the Red Sea from Iran's regional rival Saudi Arabia.
In March, Israel intercepted in the Red Sea a vessel which it said carried M-302 missiles and other weapons shipped from Iran.
They were to have been offloaded at Port Sudan and then taken overland to Palestinian militants in the Gaza Strip, Israel said.
Iran denied any involvement, and Sudan said it had no connection with the vessel which it described as being in international waters.
Previous article'Iran owes al Qaeda invaluably,' ISIS spokesman says
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Blacklisting of IRGC a Necessity for Iran's Freedom
Written Question From Rasmus Hansson (MDG) to Norway's Minister of Justice and Emergency Preparedness About Iran Regime's Threats
Belgian Parliament Passes Shameful Bill Under Government Pressure
Belgian PM Pushes Parliament To Succumb to Tehran's Terrorism


text:
Авіаносці типу «Джеральд Р. Форд» () — клас атомних авіаносців, які зараз будуються для ВМС США. Цей клас із запланованою кількістю десятьох кораблів замінить нинішні авіаносці ВМС за принципом «один за одним», починаючи з головного корабля «Джеральд Р. Форд», який замінить «Ентерпрайз», а потім, врешті-решт, займе місце чинних носіїв класу Німіц. Нові судна мають корпус, схожий на корпус класу «Німіц», але впроваджують технології, розроблені з часу програми CVN(X)/CVN-21, такі як електромагнітна система запуску літаків (EMALS), а також інші конструктивні особливості, призначені для вдосконалення. ефективність і зниження експлуатаційних витрат, включаючи плавання з невеликим екіпажем. Цей клас авіаносців названий на честь колишнього президента США Джеральда Р. Форда. Перший корабель класу, CVN-78, був придбаний у 2008 році та прийнятий на озброєння 22 липня 2017 року. Другий корабель класу, «Джон Ф. Кеннеді», як очікується, буде введено в експлуатацію у 2024 році.

Особливості конструкції
Авіаносці класу «Джеральд Р. Форд» мають:

 Удосконалене спорядження для арешту
 Автоматизація, що дозволяє мати екіпаж на кілька сотень менше, ніж в авіаносця класу «Німіц».
 Оновлена ракета RIM-162 Evolved SeaSparrow
 Багатофункціональний радар AN/SPY-3 X Band і об'ємний пошуковий радар AN/SPY-4 S Band. Позначаються разом як Dual Band Radar (DBR), спочатку розроблений для есмінців типу «Зумвольт». Починаючи з Джона Ф. Кеннеді (CVN-79), AN/SPY-6 замінить AN/SPY-4 як компонент системи томового пошуку.
 Електромагнітна система запуску літаків (EMALS) замість традиційних парових катапульт для запуску літаків.
 Нова конструкція ядерного реактора (реактор A1B) для більшого виробництва електроенергії.
 Стелс-функції для зменшення поперечного перерізу радара.
 Можливість перевозити до 90 літаків, включаючи F/A-18E/F «Супер Хорнет», EA-18G «Гроулер», C-2 «Грейхаунд», E-2 «Хокай», F-35 «Лайтнінг» II, вертольоти Sikorsky SH-60 Seahawk, бойові безпілотні літальні апарати.

Найбільшою видимою відмінністю від ранніх суперавіаносців є більш кормове розташування острова (надбудови). Авіаносці класу «Джеральд Р. Форд» матимуть знижену вартість експлуатації, частково через зменшення кількості екіпажу. Ці кораблі розраховані на витримку 160 вильотів на день протягом 30 з гаком днів, з можливостями наростання 270 вильотів на день. Директор з операційних випробувань Майкл Гілмор розкритикував припущення, використані в цих прогнозах, як нереалістичні та вказав, що швидкість вильотів, подібна до 120/240 вильотів на день класу Nimitz, була б прийнятною.

Розробка
Нинішні авіаносці класу «Німіц» на військово-морській службі США були частиною стратегії прогнозування потужності Сполучених Штатів з моменту введення «Німіца» в експлуатацію в 1975 році. Водотоннажність класу «Німіц» при повному завантаженні може розвивати швидкість понад 30 вузлів (56 км). /год), здійснювати польоти без поповнення запасів протягом 90 днів і запускати літаки для завдавання ударів по цілях за сотні миль. Прикладом витривалості класу Nimitz є корабель USS Theodore Roosevelt, який провів 159 днів під час операції Enduring Freedom, не відвідуючи порт і не дозаправляючись.

Дизайн Nimitz вміщує багато нових технологій протягом десятиліть, але він має обмежену здатність підтримувати найновіші технічні досягнення. Як говорилося у звіті Ренда за 2005 рік, «найбільша проблема, з якою стикається клас Nimitz, полягає в обмежених можливостях виробництва електроенергії та зумовленому модернізацією збільшенні ваги корабля та ерозії запасу центру ваги, необхідного для підтримки остійності корабля».

Враховуючи ці обмеження, ВМС США розробили те, що спочатку було відомо як програма CVN-21, яка перетворилася на CVN-78, Джеральд Р. Форд. Удосконалення були зроблені завдяки розробці технологій і більш ефективному дизайну. Основні зміни конструкції включають більшу кабіну польоту, вдосконалення озброєння та транспортування матеріалів, нову конструкцію силової установки, яка вимагає менше людей для експлуатації та обслуговування, а також новий, менший острів, який був відсунутий на корму. Технологічний прогрес в електромагнетиці призвів до розробки електромагнітної системи запуску літака (EMALS) і передового механізму зупинки (AAG). Інтегрована система ведення бойових дій, система самооборони корабля (SSDS), була розроблена, щоб дозволити кораблю легше виконувати нові місії. Новий дводіапазонний радар (DBR) поєднує радари S-діапазону та X-діапазону.

Ці досягнення дозволять новим авіаносцям класу «Джеральд Р. Форд» здійснювати на 25 % більше бойових вильотів, генерувати втричі електроенергію з покращеною ефективністю та покращити якість життя екіпажу.

Злітна палуба
Вид з висоти пташиного польоту Джеральда Р. Форда (CVN-78) поряд із USS Harry S. Truman (CVN-75), кораблем попереднього класу Nimitz

Катапульта № 4 класу Nimitz не може запускати повністю завантажений літак через низький просвіт крила вздовж краю польотної палуби.

Переміщення зброї від місця зберігання та складання до літака в кабіні екіпажу також було оптимізовано та прискорено. Боєприпаси будуть підняті до централізованого місця переозброєння за допомогою елеваторів більшої місткості, які використовують лінійні двигуни. Ці ліфти розташовані таким чином, що боєприпасам не доводиться перетинати будь-яку зону руху літаків, що зменшує проблеми руху в ангарах і на екіпажі. У 2008 році контрадмірал Денніс М. Дваєр сказав, що ці зміни гіпотетично дозволять переозброїти літаки за «хвилини замість годин».

Енергозабезпечення
Новий реактор Bechtel A1B для класу «Джеральд Р. Форд» менший і простіший, потребує менше екіпажу, але набагато потужніший за реактор A4W класу Nimitz. Два реактори будуть встановлені на кожному носії класу «Джеральд Р. Форд», що забезпечить потужність виробництва електроенергії щонайменше на 25 % більше, ніж 550 МВт (теплова) двох реакторів A4W на носії класу Nimitz. Частка теплової енергії, що відводиться на виробництво електроенергії, буде збільшена втричі.

Силова установка та енергетична установка носіїв типу Nimitz були розроблені в 1960-х роках, коли бортові технології вимагали менше електроенергії. «Нові технології, додані до кораблів класу "Німіц", спричинили збільшення потреби в електроенергії; поточне базове навантаження залишає невеликий резерв для задоволення зростаючих потреб в електроенергії».

Кораблі типу «Джеральд Р. Форд» перетворюють пару на енергію, направляючи її до чотирьох головних турбогенераторів (MTG) для виробництва електроенергії для основних корабельних систем і нових електромагнітних катапульт. Судна типу «Джеральд Р. Форд» використовують парові турбіни для руху.

Більша вихідна потужність є основним компонентом інтегрованої бойової системи. Інженери вжили додаткових заходів, щоб забезпечити можливість інтеграції непередбачених технологічних досягнень на авіаносець типу «Джеральд Р. Форд». ВМС очікують, що клас «Джеральд Р. Форд» буде частиною флоту протягом 90 років, до 2105 року, що означає, що клас повинен успішно сприймати нові технології протягом десятиліть. Лише половина потужностей з виробництва електроенергії використовується поточними планованими системами, а половина залишається доступною для майбутніх технологій.

Електромагнітна система запуску літаків
Електромагнітна система запуску літаків (EMALS) запускає літаки за допомогою катапульти, в якій використовується лінійний асинхронний двигун, а не паровий поршень, який використовується в класі Nimitz. EMALS прискорює літак більш плавно, створюючи менше навантаження на його корпус. EMALS також важить менше, очікується, що він коштуватиме дешевше та потребуватиме менше обслуговування, і може запускати як важчі, так і легші літаки, ніж система з паровим поршнем. Це також зменшує потребу перевізника у прісній воді, таким чином зменшуючи попит на енергомістке опріснення.

Система приземлення літаків
Електромагніти також використовуються в новій системі Advanced Arresting Gear (AAG). Поточна система покладається на гідравліку, щоб уповільнити та зупинити літак, що приземляється. У той час як гідравлічна система є ефективною, як продемонстровано більш ніж п'ятдесятирічною практикою, система AAG пропонує низку вдосконалень. Поточна система не в змозі захопити безпілотні літальні апарати (БПЛА), не пошкодивши їх через надзвичайні навантаження на планер. БПЛА не мають необхідної маси для приводу великого гідравлічного поршня, який використовується для захоплення важчих пілотованих літаків. За допомогою електромагнітних елементів поглинання енергії контролюється турбоелектричним двигуном. Це робить пастку більш гладкою та зменшує удари по планеру. Попри те, що система виглядатиме з кабіни екіпажу так само як і її попередник, вона буде більш гнучкою, безпечною та надійною та потребуватиме менше обслуговування та обслуговування.

Датчики та системи самозахисту
Ще одним доповненням до класу «Джеральд Р. Форд» є інтегрована активна радіолокаційна система пошуку та стеження з електронним скануванням. Компанія Raytheon розробляла дводіапазонний радар (DBR) як для есмінців з керованими ракетами типу Zumwalt, так і для авіаносців типу «Джеральд Р. Форд». Острів можна зменшити, замінивши шість-десять радарних антен на один шестигранний радар. DBR працює шляхом поєднання багатофункціонального радара AN/SPY-3 X-діапазону з випромінювачами Volume Search Radar (VSR) діапазону S, розподілених на три фазові решітки. Радар S-діапазону пізніше був видалений з есмінців Zumwalt для економії грошей.

Три грані, призначені для радара X-діапазону, забезпечують відстеження на низькій висоті та радіолокаційне освітлення, тоді як три грані S-діапазону забезпечують пошук і супровід цілі незалежно від погоди. «Одночасна робота у двох діапазонах електромагнітних частот DBR знаменує собою перший випадок, коли ця функція була досягнута за допомогою двох частот, координованих одним менеджером ресурсів».

У цій новій системі немає рухомих частин, що мінімізує потреби в технічному обслуговуванні та укомплектуванні особового складу для експлуатації. AN/SPY-3 складається з трьох активних масивів і шаф приймача/збудника (REX) на верхній палубі та підсистеми процесора сигналів і даних (SDP) на нижній палубі. VSR має подібну архітектуру, з функцією формування променя та вузькосмугового перетворення вниз, що відбувається у двох додаткових шафах на масив. Центральний контролер (менеджер ресурсів) знаходиться в процесорі даних (DP). DBR є першою радіолокаційною системою, яка використовує центральний контролер і два радари з активною решіткою, що працюють на різних частотах. DBR отримує живлення від системи живлення загального масиву (CAPS), яка складається з блоків перетворення живлення (PCU) і блоків розподілу живлення (PDU). DBR охолоджується за допомогою замкнутої системи охолодження під назвою Common Array Cooling System (CACS).

Enterprise Air Surveillance Radar (EASR) — це нова конструкція оглядового радара, який буде встановлено на другому авіаносці типу «Джеральд Р. Форд» «Джон Ф. Кеннеді» (CVN-79) замість дводіапазонного радара. Десантні кораблі класу «Америка», починаючи з LHA-8 і планованого LX(R), також матимуть цей радар. Початкова вартість комплекту EASR за одиницю буде приблизно на 180 мільйонів доларів менше, ніж DBR, для якого оцінюється приблизно.

Можливі покращення
Майбутні системи захисту, такі як зброя спрямованої енергії з лазером на вільних електронах, електрична броня та системи стеження, вимагатимуть більшої потужності. «Лише половина можливостей генерації електроенергії на CVN-78 необхідна для роботи запланованих систем, включаючи EMALS. Таким чином, CVN-78 матиме запаси потужності, яких бракує класу Nimitz для запуску лазерів і електричної броні». Додавання нових технологій, систем живлення, компонування дизайну та кращих систем керування призводить до підвищення швидкості вильотів на 25 % порівняно з класом Nimitz та 25 % скорочення робочої сили, необхідної для роботи.

Технологія управління відходами буде розгорнута на «Джеральд Р. Форд». У 2008 році компанія PyroGenesis Canada Inc., яка була розроблена спільно з відділом Carderock Центру військово-морських надводних військ, отримала контракт на оснащення корабля плазмово-дуговою системою знищення відходів (PAWDS). Ця компактна система очищатиме всі тверді горючі відходи, які утворюються на борту судна. Після завершення заводських приймальних випробувань у Монреалі систему було заплановано відправити на верф Huntington Ingalls наприкінці 2011 року для встановлення на носій.

ВМС розробляють лазер на вільних електронах (FEL) для захисту від крилатих ракет і невеликих човнів.

3D автоматизоване проєктування
Компанія Newport News Shipbuilding використовувала повномасштабну тривимірну модель продукту, розроблену в Dassault Systèmes CATIA V5, для проєктування та планування будівництва авіаносців класу «Джеральд Р. Форд».

Клас CVN 78 був розроблений, щоб мати кращі траєкторії руху зброї, значною мірою усуваючи горизонтальні рухи всередині корабля. Поточні плани передбачають переміщення передових ліфтів для зброї із зон зберігання до спеціальних зон обробки зброї. Моряки використовували моторизовані візки для переміщення зброї зі сховищ до ліфтів на різних рівнях збройових магазинів. Лінійні двигуни розглядаються для передових елеваторів озброєння. Ліфти також будуть перенесені таким чином, щоб вони не перешкоджали роботі літаків у кабіні польотів. Реконструювання шляхів переміщення озброєння та розташування ліфтів озброєння на кабіні польоту зменшить кількість живих сил і сприятиме значно вищому вильоту.

Оновлення комплектації
Клас Джеральда Р. Форда призначений для розміщення нового палубного літака Joint Strike Fighter (F-35C), але затримки в розробці та випробуваннях літака вплинули на діяльність з інтеграції CVN-78. Ця інтеграційна діяльність включає випробування F-35C з EMALS CVN-78 і вдосконаленою системою блокування, а також випробування можливостей зберігання літій-іонних акумуляторів, шин і коліс F-35C. Через затримки у розробці F-35C ВМС США не поставлять цей літак принаймні до 2018 року — через рік після доставляння CVN-78. У результаті ВМС відклали критично важливі заходи з інтеграції F-35C, що створює ризик системної несумісності та дорогої модернізації корабля після того, як він буде доставлений до ВМС.

Приміщення екіпажу
Системи, які зменшують навантаження на екіпаж, дозволили судновій компанії на авіаносцях типу «Джеральд Р. Форд» налічувати лише 2600 моряків, приблизно на 700 менше, ніж на авіаносцях класу Nimitz. Масивні причальні зони на 180 осіб на літаках класу Nimitz замінено на 40-стійкові причальні зони на авіаносцях типу «Джеральд Р. Форд». Менші причали тихіші, а планування вимагає менше руху людей через інші простори. Зазвичай стелажі встановлюються по три у висоту, з місцем для шафки на людину. У причалах відсутні сучасні «сидячі» стійки з більшим простором для голови; нижня і середня стійки вміщують тільки лежачого моряка. Кожне причальне місце має пов'язану верхню частину, включаючи душові кабіни, туалети з вакуумною септичною системою (без пісуарів, оскільки причальні місця побудовані з гендерною нейтральністю) і раковини, щоб зменшити рух і трафік для доступу до цих приміщень. Зали з підтримкою Wi-Fi розташовані навпроти проходу в окремих місцях від причальних стійок.

З моменту розгортання у перших двох авіаносців цього класу виникли проблеми з водопроводом системи відходів. Труби були надто вузькими, щоб впоратися з навантаженням користувачів, що призвело до виходу з ладу вакууму та неодноразового засмічення туалетів. Щоб полегшити проблему, для промивання каналізаційної системи використовувалися спеціальні кислотні мийні розчини. Ці процедури очищення коштують приблизно 400 000 доларів кожного разу, що призводить до значного незапланованого збільшення витрат на експлуатацію цих кораблів за весь термін експлуатації згідно з GAO. Ці очищення доведеться виконувати протягом усього терміну служби корабля.

Медичні заклади
Джеральд Р. Форд, перший у своєму класі, має бортовий госпіталь, який включає повну лабораторію, аптеку, операційну, відділення інтенсивної терапії з 3 ліжками, відділення невідкладної допомоги з 2 ліжками та лікарняну палату на 41 ліжко, де працюють 11 осіб. медпрацівників і 30 санітарів.

Першокласні зміни в дизайні
По ходу будівництва CVN-78 суднобудівник виявив першокласні зміни в конструкції типу, які він використовуватиме для оновлення моделі перед будівництвом інших суден свого класу. Деякі з цих змін конструкції стосувалися змін конфігурації EMALS, які вимагали електрики, електропроводки та інших змін на кораблі. Військово-морські сили очікують додаткових змін у конструкції, що випливають із розробки та випробувань удосконаленого захисного спорядження. За даними військово-морського флоту, багато з цих 19 000 змін були запрограмовані в графік будівництва на ранній стадії — в результаті рішення уряду під час укладення контракту запровадити вдосконалення бойових систем корабля під час будівництва, які значною мірою залежать від розвитку комерційних технологій.

Найменування
Асоціація ветеранів авіаносців USS America спонукала до того, щоб CVN-78 назвали на честь Америки, а не на честь президента Форда. Згодом десантний корабель LHA-6 отримав назву «Америка».

27 травня 2011 року Міністерство оборони США оголосило, що назвою CVN-79 буде USS John F. Kennedy.

1 грудня 2012 року міністр ВМС Рей Мабус оголосив, що CVN-80 буде називатися USS Enterprise. Інформація була озвучена під час попередньо записаної промови в рамках церемонії дезактивації попереднього Enterprise (CVN-65). Майбутній Enterprise (CVN-80) стане дев'ятим кораблем ВМС США з такою назвою.

20 січня 2020 року під час церемонії в Перл-Гарборі на Гаваях у День Мартіна Лютера Кінга-молодшого виконувач обов'язки міністра ВМС Томас Б. Модлі назвав майбутній авіаносець типу «Джеральд Р. Форд» на честь героя Другої світової війни «Доріс Міллер». Це буде перший авіаносець, названий на честь афроамериканця, і перший авіаносець, названий на честь рядового моряка. Це другий корабель, названий на честь Доріса Міллера, який був першим афроамериканцем, що отримав Військово-морський хрест

Примітки

Джерела
 Navy Ford (CVN-78) Class Aircraft Carrier Program: Background and Issues for Congress

Класи авіаносців

Авіаносці типу «Форд»


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Bazylika Sant'Agostino w Rzymie
 Bazylika katedralna w St. Augustine


Jon Stewart: The Goat Savior??
Jon Stewart came to the rescue of two stray goats found roaming the subway tracks of New York City this week by giving them a home at his animal rescue operation … no joke!
No word on where exactly these two billy goats gruff came from — or where the third one might be — but Stewart stepped in to offer them a place to stay — his Farm Sanctuary in Watkins Glen, NY, which he owns with his wife. He also saved a runaway cow a couple years back.
Jon's sanctuary says the two goats are both boys … and they've named them Billy and Willy.
Previous Whoah! We are doing this all wrong!


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Bukit Timah Nature Reserve Tours
Bukit Timah Nature Reserve occupies a 400-acre (1.6 square kilometer) swath of land on the slopes of Bukit Timah Hill, the tallest hill in Singapore. While relatively small, the reserve -- one of the oldest established forest reserves in the country -- is surprisingly rich in biodiversity with more than 500 species of birds and animals and some 840 species of plants. The park is quite popular with hikers, joggers and bird watchers.
The entire road to the peak of Bukit Timah Hill is paved, making it a relatively easy trek through the lush forest. You'll find placards in English along the entire length of the path offering more information on the wildlife that live there. You'll also find a few trails dedicated to mountain bikers. Entrance to the park is free, making it a good option for a short day trip from the city. Mosquitoes can be a problem, so bring along your bug spray.
Address: Bukit Timah Nature Reserve, Singapore
Hours: Daily: 6am - 7pm (Night walking within the reserve is not encouraged).
0 Tours and Activities to Experience Bukit Timah Nature Reserve
What are Bukit Timah Nature Reserve hours of operation?
Bukit Timah Nature Reserve hours of operation: Daily: 6am - 7pm (Night walking within the reserve is not encouraged).. Buy tickets in advance on Viator. If you book with Viator, you can cancel at least 24 hours before the start date of your tour for a full refund.
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The corporate world is always looking for apps and tools of all kinds that will increase productivity. After all, helping employees work more productively should go straight to the bottom line, resulting in higher revenue and profits. But finding the right apps to make employees more productive isn't necessarily easy. With that in mind, this slide show highlights 10 productivity apps that have been generally well-received among companies both large and small. From the natural choices, such as Slack and GoToMeeting, to some lesser-known tools such as the Clarizen project management app, here is eWEEK's take on some of the best productivity-boosting apps for companies of all sizes.
Slack is one of the more popular—and appealing—productivity tools in this roundup. Slack allows users to communicate via text, photo and video and has both public and private channels for team collaboration. It's also a file-storage platform that helps cut down on email. Slack is a handy app for companies regardless of their size.
Microsoft Teams is the cloud and software giant's answer to Slack. Like Slack, Microsoft Teams has channels and enables users to communicate both in private and in public with others. Microsoft Teams is baked into Office 365, however, so companies not using that platform will need to look elsewhere.
Microsoft's Yammer has proven to be one of the workhorse apps in the company's broader Office 365 ecosystem. The tool enables employees to communicate and share files and folders. And because it's integrated in Office 365, sharing files internally is a cinch. Yammer isn't as comprehensive as Microsoft Teams, but it's ideal for companies that need a simpler productivity solution.
For companies with an increasingly telecommuting workforce, GoToMeeting can be exceedingly useful. The service enables voice and video calling, and its collaboration features means employees can work together even when they're half a world away. Best of all, GoToMeeting works on a range of devices including computers, tablets and smartphones.
Clarizen doesn't have the biggest name in this roundup, but this cloud-based tool is one of the more powerful project-management services on the market. Teams can create projects, manage them in real time and share files over the web. Clarizen also comes with impressive security features to keep company files safe.
Basecamp is designed for companies that don't want all the power and features of Clarizen and instead want a simple interface for getting work done. With Basecamp, employees can collaborate on projects, share files and stay on top of tasks, all in the same pane. Basecamp's secret sauce is its simplicity, which makes it easy for companies to create teams and projects and keep employees on task.
BrightIdea is a tool designed for companies that want to drive innovation in the workplace. The app includes a host of tools designed to foment ideas, including discussion areas for brainstorming and problem-solving, and as a place to develop and incubate business opportunities out of the concept stage. Tools built into BrightIdea let managers monitor the evolution of an idea from concept to implementation.
Although big companies might require higher-end accounting tools such as Quickbooks, FreshBooks is a lower-end alternative. The cloud-based accounting tool helps companies track their revenue and expenses, create invoices and facilitate payments with customers. FreshBooks also includes time-tracking and reporting features.
Asana is another project-management tool aimed at making it easier for companies to determine what needs to get done and assign the right employees to do it. The tool, which works both in the cloud and on mobile devices, includes a chat feature and tracking tools for updating managers on task progress. Individuals have their own portal to see what they need to get done and when.
Trello is a workflow app that helps keep companies organized. Companies can create different boards that are populated with task cards that can be assigned to others. Trello allows employees to grab tasks and inform managers when they're complete, as well as create their own task cards to let folks know what they're working on. Trello also can be integrated into Slack.


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Six Locally Developed Android Applications Launched At Kenya's Strathmore University.
by Caroline Vutagwa
Samsung Electronics East Africa has today unveiled six androids apps developed locally by Kenya's Strathmore IT students, following a partnership research project with the University.
The newly launched apps, that will be available on the Samsung app store in one week's time, are part of the program that saw the global electronics giant work closely with Strathmore's iLab Africa to train and nurture students to come up with localized android applications.
Samsung Electronics East Africa Chief Operating Officer, Robert Ngeru had this to say: "The Samsung app store is accessed by millions of mobile phone subscribers' globally seeking to download quality android applications in diverse categories such as entertainment, education, games, lifestyle, travel and productivity among others. Kenyan app developers on the android platform have equal access to other global developers to show case their solutions on the Samsung apps store which is a gateway to global technology entrepreneurship."
The apps launched include:-
'Kenya Law Reports Application' which allows lawyers and the general public access information such as the constitution, updates on case files, schedule of court cases and the law of Kenya
The Pharmaceutical Poisons Board App, that allows the public to easily recognize and report side effects on drugs, while also providing a platform to locate and engage a registered pharmacist among other uses.
The 'Strathmore Business School App' which enables them to easily manage their lecture sessions, study group schedules and download lecture content and assignments from the SBS e-learning system. This application also always copy write protection and can be adapted to suit any college and curriculum.
The 'Church Application' which enables users to access general Christian information of people sharing their favorite scriptures, what they like about being a Christian, etc
'Kitoweo African Cuisine' App which provides recipes of African foods.
The partnership is part of Samsung's business growth strategy for Kenya and the rest of Africa, which is based on creating an entrepreneurial attitude among the Kenyan youth in the ICT sector.
Through this strategy, Samsung Electronics has put a keen focus on education, strategically seen through the Samsung Engineering Academy which has to date trained thousands of students regionally, providing them with a platform to start their ICT enterprises. The Samsung Digital Village also utilizes solar powered solutions to deliver e-learning and business solutions.
Strathmore University Director for iLab Africa, Dr. Joseph Sevilla said: "The changing business ecosystem calls for innovation among the players, as people constantly seek out the best value for money, user experience and mobile utility."
Caroline Vutagwa
Minding my own business is not enough for me that's why you will always find me minding Africa's Businesses as well as Technology and of course letting you know about it. Talk to me on vutagwao[email protected]


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Google: On the predictability of Search Trends
http://googleresearch.blogspot.com/2009/08/on-predictability-of-search-trends.html
Google prediction predictability future statistics probability emergence
The DOD is developing a parallel to Planet Earth, with billions of individual "nodes" to reflect every man, woman, and child this side of the dividing line between reality and AR. Called the Sentient World Simulation (SWS), it will be a "synthetic mirror of the real world with automated continuous calibration with respect to current real-world information", according to a concept paper for the project. "SWS...
http://www.theregister.co.uk/2007/06/23/sentient_worlds/
future simulation military virtual reality war politics game emergence complexity
Malaysian web users team up for crowd-sourced film
Crowd-sourcing - the practice of enabling many people to help on a single task - is seen as one of the great triumphs of the world wide web. But one project in Malaysia is set to put the wisdom of crowds to the ultimate test, as it attempts to create a full-length feature film.
Malaysia crowdsourcing movie collaboration emergence story writing
(direct)
http://vacilando.net/running/strijdersstraat-laarbeekbos-x/2012-07-17/004020
http://vacilando.net/brilliant_gallery_examples
http://hypergraph.sourceforge.net/applications.html
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Clay Minerals (2005) 40 (1): 63-66.
At 25°C, synthetic schwertmannite, a common iron compound in acid mine drainage, completely converted in water to a sulphate-containing goethite within ~100 days. The rate of transformation doubled as the pH increased from 4.0 to 7.2. In deviation from its normal acicular habit, the goethite appeared as spherical aggregates.


Until 1926 Ivinghoe was dominated by Roberts and Wilson's Brewery.
Like many villages, the two world wars featured very much in their history.
the Pitstone Cement works silos.
covered with many interesting pictures and posters.


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Чемпионат Европы по фигурному катанию 1910 года проходил в Берлине (Германская империя) 10—11 февраля. Соревновались только мужчины. Победу одержал Ульрих Сальхов.

Результаты

Судьи:
 A. Strasilla  Германская империя
 Мартин Гордан  Германская империя
 H. Wendt  Германская империя
 P. Kersten  Германская империя
 Fritz Hellmund  Германская империя
 Франц Цилли  Германская империя
 E. Schirm  Германская империя

Ссылки
 Список призёров чемпионатов Европы
 Результаты чемпионатов Европы 1900—1914 годов

Чемпионаты Европы по фигурному катанию
Международные спортивные соревнования в Берлине
1910 год в фигурном катании
Европа
Февраль 1910 года
Спорт в Германии в 1910 году
Чемпионаты Европы в Германии
Чемпионаты Европы в 1910 году