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This is the REAL Moonlighting
rsteele
This is the REAL Moonlighting Aug 20, 2008 16:33:54 GMT -5
Post by rsteele on Aug 20, 2008 16:33:54 GMT -5
If I was to introduce a newbie to this show, this is the Ep I'd show after the pilot. Maybe I have a weakness for late night call-in shows ala SLEEPLESS IN SEATTLE, but that McCain guy with that story of the gal with seven hearts kinda reached me. #
Then David getting on Maddie's case about having no social life and going to bed at 9:30 alone, has her say to herself, "I hate you David Addison", and getting dressed and going out to see what she's missing. Meanwhile David's doing a drunken rendition of R-E-S-P-E-C-T in a bar, and is found hanging around Maddie's closet at work, hung over. Oh yeah, there's the "boink" ride. #
The Paul McCain character gives the episode a special feeling, as he's one of the few "victims" in the whole series I was really rooting for. The Best Ep of Season 1!
Post by beesnbears on Aug 21, 2008 10:57:16 GMT -5
Rsteele, I agree. I think this is the first episode I saw way back when they were repeating the first season during the summer. David's bar scene has always stood out in my mind.
Also, the alley scene in "Gunfight.....". Those 2 episodes did it for me 20 years ago!!
It cracks me up on the first dvd that they use the bar scene in "Gunfight" as part of the intro where David and Maddie walk in and he has the cigarette. "Yo, you remember me?!?!" ;D
Of course we do!!!
This is the REAL Moonlighting Aug 23, 2008 3:18:55 GMT -5
Post by bluevelvet on Aug 23, 2008 3:18:55 GMT -5
By coincidence, this was the first episode that I saw when we were having re-runs here in New Zealand 3 years ago and it was the first time I had seen any episodes since Moonlighting's original airing. It hooked me again in a really powerful way and reminded me why I had been keeping an eye on both Bruce and Cybill's careers for the last 20 years. Love it, and I agree - a great episode to show to newbies.


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Report: Kids Use Less Marijuana in States That Have Legalized
2021 saw a big drop in cannabis use among high schoolers and middle schoolers. Opinions expressed by Entrepreneur contributors are their own. According to a new federally-funded survey, the use of cannabis by those under 18 dropped by a significant amount in 2021. The report, released by Monitoring the Future, found a drop for students in the 8th, 10th, and 12th grades. The findings debunk a myth that legal weed would lead to more teens getting high. Researchers measured drug use among the nation's teens and discovered that cannabis use dropped to levels not seen since the early 1990s. The University of Michigan conducted the survey, funded by the National Institute on Drug Abuse. The biggest drop in teen cannabis use since 1975 In all areas, including cannabis use, the survey found the most significant drop in teen use since 1975. In a press release issued along with the study, NIDA Director Nora Volkow credited some of the drop to the COVID-19 pandemic. "We have never seen such dramatic decreases in drug use among teens in just a one-year period," Volkow said . "These data are unprecedented and highlight one unexpected potential consequence of the COVID-19 pandemic, which caused seismic shifts in the day-to-day lives of adolescents." The survey found the following percentage drops in cannabis use by teens by grade. 7.1 percent of 8th graders reported marijuana use in the past year, compared to 11.4 percent in 2020 17.3 percent of 10th graders reported using marijuana in the past year, compared to 28 percent in 2020 30.5 percent of 12th graders reported using marijuana in the past year, compared to 35.2 percent in 2020 What happens when the pandemic is under control? Volkow said the key in 2022, a year in which experts hope the coronavirus becomes endemic rather than a pandemic, officials will need to gather information on the details of what caused the drop in 2021. "Moving forward, it will be crucial to identify the pivotal elements of this past year that contributed to decreased drug use – whether related to drug availability, family involvement, differences in peer pressure, or other factors – and harness them to inform future prevention efforts," Volkow said. Each year, the university conducts the survey with students who self-report their substance use over varying periods, including the past month, year, and over their lifetime. The 2021 report included surveys from 32,260 students enrolled in 319 U.S. public and private schools. The results of the survey mirror those from studies in Colorado and Washington conducted last year. Those found that weed use by teens did not increase, and in some cases, dropped after the state legalized recreational cannabis. The studies also found no increase in auto accidents involving teens using cannabis after legalization. Follow dispensaries.com on Instagram to stay updated on the latest cannabis news. More About Cannabis Green Entrepreneur® and its related marks are registered trademarks of Entrepreneur Media Inc. The information contained on this website ("Content") represents the views and opinions of the persons or entities expressing them. The Content does not represent an endorsement by, or the views and opinions of, Entrepreneur Media, Inc. ("EMI"), is intended for informational and educational purposes only, and should in no way be interpreted as medical, legal, or any other advice concerning the cultivation, sale, or any other use of marijuana, which, although legal in some states and local jurisdictions throughout the United States, is currently illegal under federal law, as well as in other states and local jurisdictions. Because of the variety of laws, regulations, and ordinances concerning marijuana, the Content may not be suitable for your situation. Consequently, EMI makes no expressed or implied warranties nor assumes any liability whatsoever, concerning the accuracy or reliability of the information contained herein, including warranties about the legality of, or likelihood of success in, conducting a cannabis business. EMI does not advocate violating applicable law, and therefore strongly recommends that you carefully research applicable laws, and consult with appropriate licensed professionals and other experts, before taking any action in connection with, or based on, such Content. 250) ? true : false" x-cloak>
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Mike Brewer, CEO of Rhema Media, talks with George & Andrew about his hopes and plans for Rhema in 2015.
Hillsong's Young & Free had their first overseas gig in NZ just over 12 months ago. Now they're back for Cloud Festival. Alex from Young & Free talks about the amazing year the band has had.
Saudi Arabia has declared that all atheists are terrorists, John talked with Prof Steven Hoadley this morning.
Todd White was a drug addict and atheist for 22 years - after a dramatic conversion experience he is now an evangelist with a powerful international Ministry.
He will be one of the Speakers at Cloud Festival this weekend.
Joel from Cloud Festival talks to George & Andrew about some of the speakers and seminars that will be a big part of the Cloud Festival this weekend.


Spike Lee's new film BlacKkKlansman is a movie that I have been looking forward to ever since I first heard it announced. Produced by Get Out's Jordan Peele, the film follows a black cop (John David Washington) who uses a white surrogate (Adam Driver) to help him infiltrate the Klu Klux Klan. It's based on a true story, and it sounds absolutely fascinating. And the pairing of Jordan Peele with Spike Lee makes for a dream team. They have both proven themselves to be able to tell compelling and unique stories about race, and I think a story like this really plays to their strengths. I have had incredibly high hopes for this movie since the beginning. Though, I'm not crazy about the title. I preferred it back when it was just "Black Klansman". Putting "KKK" into the title just looks stupid, and I wish they hadn't done that. But it's just the title, and it doesn't mean anything for the actual movie. I have been really looking forward to seeing a trailer for this film in order to finally get a sense of what it will be like. And now we have our first trailer for BlacKkKlansman, which opens in theaters on August 10.
I really liked this trailer a lot. It immediately establishes the atmosphere and the tone of the film right off the bat. It is certainly a drama, but it is leaving itself room to have fun and be lighthearted, and I think that is incredibly important. Nazism and the Klan are hot-button topics right now, and is the center of a lot of tragedy and pain in our current political climate. You need to be able to have fun with this, or else it runs the risk of alienating people. And that's why Spike Lee is such a perfect fit for this project. He can handle the gravity of the situation while also interjecting some fun into it. And traversing drama and comedy in regards to a racially driven story is what Jordan Peele just did with Get Out, so they really are the dream team when it comes to making BlacKkKlansman. I also love all the production and costume design. They are going all-in on making this feel like the 70's, and it really helps with crafting the film's atmosphere. Overall, I cannot wait for this movie. They have an excellent team behind the camera. They have incredible talent in front of it. The premise sounds intriguing. The trailer promises a fun, compelling film that targets racism in a very direct way. With all of that combined, I can't wait to see this movie.
What do you think? Did you like the first trailer for BlacKkKlansman? Are you planning on seeing the film? Leave your thoughts in the comments section below.


I dont think my 'keep it simple and make an impact' mentality will win this comp but I'd still like to see if I can get 2nd or 3rd place. Is the voting ever going to happen? How will it happen? Are the 'judges' deliberating as we speak, or will it be a public vote? I think I read something about it being public, so... when?
I have had about 6 burgers in the last four days. :shock: :x or 8) ?
10/10 amazing! I've seen and checked out your stuff before. I wish I could do what you do!
^ Wrong! I've actually seen and checked out your stuff before. I wish I could do what you do! < Should be working! v Should be working?
Thanks for the comment. Yes, I do work fast. I must say, having BoltBait's tutorials and "C++ for Dummies" available is very helpful. :wink: Well, this is a good plugin. Have you tried it yet? I use it all the time. I am aware that I rushed too quickly to publish. Color Target v1.3 is very useful. The other effects are included because they are useful, but only in specific colour/brightness circumstances. Because of it's usefulness, I will leave it as is and keep developing it behind the scenes. If and when I come up with something brilliant, then I will re-publish, but that wont be soon.
Updated! Color Target v1.0 is now obsolete. The original post now has a link to the new Color Target Plugin Pack, which includes Color Target v1.3. I hope you enjoy these new effects. Please feel free to post anything that you have made using these tools right here. Thanks.
The Tag Maker of the Month; Comp 1 - BoltBait Wins!
rwp80 replied to Ego Eram Reputo's topic in Plugins - Publishing ONLY!
I am amazed at your super-quick response! Thanks! Did someone shine this above you? :wink: I hope this turns out to be helpful. I'm quite pleased with my red bear, although the amazon river demo turned out to be very ugly.
Updated! My first plugin is already obsolete! You can just attach the *.zip file to the original post. See the bottom of the post editor, just under the submit button is a file attachment area. click the browse button to upload directly from your computer and attach to the post. Ahh, I didn't know that. However, I remember faintly something about all plugins having to be hosted off site. (I better re-check the rules!) Coding a checkbox is reasonably easy once you know how. Check out my WhichSymbol code here for checkbox syntax: viewtopic.php?p=194899#p194899Thanks for the plugin! Thank you for reading/testing/commenting! I hope this new version turns out to be more useful!


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Yesterday, US officials said you had no right to online privacy — we don't agree so here's Internet Noise to help you out
The pen is mightier than the sword -- the keyboard will be mightier than the mallet.
by Alexandru Micu
in Science, Tech
In the wake of yesterday's decision by the House of Representatives to allow internet service providers to sell browsing data, one programmer is determined to make that data as worthless as possible — and he's willing to share his work.
If you're anything like me, when the House of Representatives decided yesterday that ISPs can sell your browsing data to basically anyone, you were positively furious. The word bull and something closely resembling the word "ship" rolled around in my head like a marble in a cup. I go to the Internet partly to work, partly to disconnect from the real world. And I like my privacy for both of those things.
"You can't have it." — bunch of US officials.
Harsh, I still want my privacy. I wanna browse pictures of cats in peace, then share a laugh over them without someone uninvited seeing any line of chat. I want to read NASA's latest tidbits without the NSA (subtracting an A makes a huge difference) peering over my shoulder.
It's my experience. It's my little corner of the immaterial. I don't want anyone to burst in on it. If I wanted to be under constant surveillance I'd fly to London. But I don't, so I just Google-Map London and use the tiny yellow guy to see the sights.
That's not how it works, though, and I know that. ISPs keep track of everything you do because they actually connect you to the disjointed bits and servers to create the seamless Internet we know and love. For the most part, they had to keep this data to themselves, so we had some modicum of privacy. That's about to change for those of you living in the US, congrats, since that data is now up for grabs by anyone who can pay for it — and make no mistake, people will pay for it, profile you with it, and then try to sell you stuff according to that profile. Because capitalism.
I'm not a fan of that. Somehow it manages to have this 1984-meets-Brave New World vibe and I don't want any of it, no siree. Paint me a barbarian but I'd rather not get a 10% discount on something I may actually want if it means a server somewhere is crunching my 3 AM alcohol-fueled-research of exotic cuisine on Wikipedia like so many 1's and 0's.
Luckily, there's one brave soul out there who feels the same way I do but also has the skills to do something about it. His name is Dan Schultz, and he has the next-best-thing after Internet invisibility. Dan heard about the vote on Twitter somewhere around 1 AM, turned off Zelda and coded Internet Noise — a tool which will shotgun searches in your browser left and right, all in the name of foggifying your real searches in a deluge of random 'noise'.
"I cannot function in civil society in 2017 without an internet connection, and I have to go through an ISP to do that," he says.
Internet Noise acts like your run of the mill browser extension, but in truth, it's just a website which will auto-open a bunch of random Google search tabs. The idea is that if you can't keep an ISP from profiling you, you can at least give them a false image of yourself. It's a pretty sad thing to need such a tool, and Schultz himself hopes that Noise will help people understand the risk their online privacy is under at this point.
It's a pretty straightforward program. Schultz simply googled "top 4,000 nouns" and made a gibberish-list with all of them. With a click on "Make some Noise", Internet Noise draws on the magic powering Google's "I'm feeling lucky" button to search for those terms or permutations of them, opening five tabs of results. Ten seconds later, you get another five, then five more, and so on. It will keep going until you hit "STOP THE NOISE!", by which point your browsing history should look like a potpourri of random links. Schultz says the best way to use it is to start the Noise when you call in for the night and stop it the next day.
Soon enough, you'll start seeing some pretty random stuff popping up in your Facebook feed, for example. Stuff you won't have the first clue as to what it is, and that that's proof the Noise is working, muddying your Internet activity profile, causing algorithms to spew out all kinds of false positives.
Image credits g4ll4is / Flickr.
Still, it's not a do-all-end-all program. Anyone slightly more competent than your average advertising company could probably pick out your searches from the noise with a decent success rate since they're obviously random clicks that have little follow-through. With 4,000 terms and 16,000,000 two-word combinations of them to rifle through, it's also really unlikely to visit a page once and astronomically unlikely to visit it three or more times. It's a really random fog-maker and its activity doesn't look human or plausible enough to be truly good at masking your activity. A smart enough algorithm can probably pick Noise apart in a few seconds. But not all algorithms are smart.
It might even get you into some more hardcore surveillance if the program searches add up to something which appears sketchy. Schultz obviously hasn't been able to pedigree all the terms to see if any could land you in a spot of trouble — think "pipes", "industrial fertilizers", and "do we really need the government" in one night. I'm exaggerating on that last one just to prove a point.
At the end of the day, though, Schiltz says the main point is to raise awareness. However, the project is open source and could evolve into a more complex program. People are already contributing, fixing minor bugs and some are suggesting possible improvements. But until more efficient privacy kits become available, your only real option is to learn as much as you can about what the tools you use can and can't do and try to dodge the system as well as possible beyond what they offer.
But I do harbor hope. Internauts have never had much political traction, but they've never lacked for imagination, resourcefulness, and a brash commitment to stick it to the man when his ethics fall into question. The Noise might be feeble, but its offspring won't.
If you missed it, here's a link to Internet Noise:
Noise-me!
Tags: internetnoiseOnlineprivacy
Alexandru Micu
Stunningly charming pun connoisseur, I have been fascinated by the world around me since I first laid eyes on it. Always curious, I'm just having a little fun with some very serious science.


Living in a town consequently force people to live in modern life style, not only the ways how they are dressing should be fashionable and trendy, people who live in busy cities also need a trendy modern home to live peacefully in their home. Thus, when you just move to new cities, you also need to find home that encompass contemporary urban home decor as it will be a great home design for you. Urban home style is so stylish and clean, so when you return your home after finishing your stressful works, your urban chic home decoration will refresh your emotion and feeling.
To create your home becomes sweet urban home style, you can make over your home with major treatment or you also can give a trivial modification. However, when time is very precious to you and you have no free time to decorate your home with large scale transformation, the best idea to make your home look more contemporary and reflected urban home decor, you can handle your home with small touches by Canvass Prints to Create Beautiful Urban Home Decoration.
Your home is not urban style, when your home does not contain canvas prints. With canvass prints, your rooms will be more captivating as canvass prints can delight your mood. To show urban theme, you can hang abstract paintings, or unique pattern paintings. This canvas will bring beautiful colorful scheme for your modern home that can make your room livelier. You can hunt amazing vibrant paintings in some galleries or ask a certain artists to make it for you. Not just available in paintings, you can also meet cushions and rugs that have canvas print designs to change your home more surprising as an urban style. When you combine canvas prints with your modern interior furniture your home spontaneously will be more handsome. Be ready to get canvass prints to turn your home into great urban home decor.


Several EU ambassadors have hailed Qatar's contribution to the security of energy supplies to the international markets, particularly Europe.
They expressed their satisfaction during a visit to Qatar Petroleum (QP) headquarters in Doha on Monday. The heads of Mission of 17 European Union member countries participated in the tour and met with QP President and CEO Saad Sherida al Kaabi. They discussed ways to enhance cooperation in the field of energy and reviewed the EU-Qatar relations and the energy developments in the region.
Kaabi welcomed the EU Heads of Mission and presented a historic overview of the strong relations that has bound Qatar with various European Union member countries. He also highlighted the work of European companies in all aspects of Qatar's oil and gas industry.
"We are proud of the important and valuable relations with the member countries of the European Union. Europe is a valued partner for Qatar and particularly in Qatar's oil and gas sector, and we want to enhance that," Kaabi said.
Discussions during the meeting dealt with issues related to the local, regional and international developments affecting the oil and gas industry.
The visiting delegation comprised the heads of mission of Austria (the local EU presidency in Qatar), Belgium, Bulgaria, Croatia, Cyprus, France, Germany, Greece, Hungary, Italy, the Netherlands, Poland, Romania, Spain, Sweden, and the United Kingdom, in addition to a representative of the European Commission.


Balsa large (about 25 m side), built in concrete, mainly slate.
Collects water from a nearby well and is used to irrigate the entire farm.
Cortijo de la Noria Miura, 1 km NE of Los Navarre, near Almería road.
Balsa appreciable dimensions for the maintenance of irrigation in large farm.


(ZIZ)– Ownership of the structure which has housed the constituency 3 Labour Party branch office is now in dispute.
Legal owner of the land upon which the structure rests, Captain Val Morris has requested that former SKNLP candidate, Sam Condor, vacate the premises however Condor has refused.
Mr. Condor claims that he has been using the office for the past twenty-five years. He says the office was built with his money and, until he is compensated for the value of the structure, he will not hand over the keys.
Mr. Morris had a completely different version of events and said that Stanley Franks, not Sam Condor, was the person who contacted him about building the structure on behalf of the SKNLP.
According to Morris, through donations from CONTEC and Builders Paradise, material was acquired for construction with labour provided by constituency 3 residents and SKNLP supporters.
Mr. Morris also claimed that Condor was not being truthful about having occupied the property for 25 years. He said that the building was only about a decade old and condor had occupied it for even less time than that.
When confronted with the SKNLP and Val Morris claims that they could both prove with documentation that he had no personal stake in the construction of the constituency branch building, Condor challenged them to bring their documents, he'll bring his, and the courts will decide.


The Distinguished Service Award recognizes CAOMS members who have made a major and significant current, past, or long-standing contribution of benefit to the specialty of Oral and Maxillofacial Surgery and/or the Association through clinical, academic, research, public service or Association related activities.
The Honorary Membership Award recognizes any individual who has made substantial and distinguished contribution to the advancement of the specialty of Oral and Maxillofacial Surgery, who has rendered valuable service to the Association, and such other deserving persons as may be determined by the Executive Council. Such individuals may be nominated for appointment as an Honorary Member of the Association by the Executive Council.
In order to nominate an individual for either of the above two awards, please complete the Nomination Form (below) and email it to caoms@caoms.com or fax/mail to the CAOMS Secretariat.
Click here for a list of past recipients of such prestigious awards.


18F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (18F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover.
Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of 18F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. 131I-meta-iodobenzylguanidine (131I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced 18F-LMI1195 washout from PC12 cells, while tracer retention remained stable in the SK-N-SH cells. After 30 min of treatment, 18F-LMI1195 releasing index (percentage of tracer released from cells) from vesicle-rich PC12 cells achieved significant differences compared to cells without treatment condition. In contrast, such effect could not be observed using vesicle-poor SK-N-SH cell lines. Similar tracer kinetics after KCl or reserpine treatment were also observed using 131I-MIBG. In case of KCl exposure, Ca2+-free buffer with the calcium chelator, ethylenediaminetetracetic acid (EDTA), could suppress the tracer washout from PC12 cells. This finding is consistent with the tracer release being mediated by Ca2+ influx resulting from membrane depolarization.
Analogous to 131I-MIBG, the current in vitro tracer uptake study confirmed that 18F-LMI1195 is also stored in vesicles in PC12 cells and released along with vesicle turnover. Understanding the basic kinetics of 18F-LMI1195 at a subcellular level is important for the design of clinical imaging protocols and imaging interpretation.
The single-photon emission computed tomography (SPECT) tracer 123I-meta-iodobenzylguanidine (MIBG) targeting norepinephrine transporter (NET) is currently the most widely used clinical tracer for sympathetic nervous imaging with well-established protocols and mature guidelines based on the results achieved from several clinical trials [1, 2]. However, positron emission tomography (PET) tracers show beneficial properties compared with SPECT tracers due to the development of imaging technology over the last couple of decades. PET provides superior sensitivity and improved temporal and spatial resolution along with the possibilities of regional cardiac imaging and kinetic studies for quantification . Among the PET tracers that are currently available for NET imaging, a new class of 18F-labeled agents has drawn attention because of their longer half-life of fluorine-18 (110 min) over carbon-11 (20 min). Thereby, these 18F-labeled tracers provide a unique opportunity to further enhance the development and application of PET imaging in terms of reduction of the financial burden of hospitals, flexible novel tracer design, and labeling procedure with improved stabilities .
Currently, a couple of 18F-labeled tracers targeting the NET are available: N-[3-bromo-4-(3-18F-fluoropropoxy]-benzyl]-guanidine (18F-LMI1195) is designed for assessment of sympathetic innervation of the heart and has successfully passed through phase I clinical trial, which confirmed its tolerance in human subjects along with favorable biodistribution for cardiac imaging . [18F]4-fluoro-3-hydroxyphenethylguanidine ([18F]4F-MHPG) and its isomer [18F]3-fluoro-4-hydroxyphenethylguanidine ([18F]3F-PHPG) have also been developed in order to counteract the perfusion dependence compared to previous NET tracers . The first-in-human studies of both tracers showed clear and long-term cardiac retention .
All the abovementioned tracers share a similar structure (benzyl/phenethyl guanidine) as MIBG and therefore represent comparable properties. Among them, 18F-LMI1195 has so far caught most of the attentions from researchers due to its easy and high-yield labeling procedure that is convenient and eligible for commercial preparation and application [8, 9]. Similar to MIBG, 18F-LMI1195 is resistant to metabolism by monoamine oxidase [5, 10]. In a head-to-head comparison of 18F-LMI1195 with 123I-MIBG in isolated perfused rabbit hearts, tracer washout after vesicle turnover was accelerated by electrical field stimulation. Additionally, our group has also demonstrated that the retention of 18F-LMI1195 is resistant to desipramine chase (desipramine added after tracer delivery), which emphasizes its potential of mimicking the physiological norepinephrine turnover .
Nonetheless, although our former investigation on isolated rabbit rat heart has proved the accumulation of 18F-LMI1195 in nerve terminals, it was not sufficient enough to come to the conclusion that it was taken up into the vesicles. In a previous study, by using potassium chloride (KCl) and reserpine stimulation, the difference between extravesicular retention and granular storage of MIBG was clearly demonstrated in PC12 (vesicle-poorvesicle-rich) and SK-N-SH (vesicle-richvesicle-poor) cell lines . Therefore, in order to gain further insights and clarify the kinetics of 18F-LMI1195 at a subcellular level, we aimed to compare it with its SPECT counterpart 131I-MIBG in both cell lines, as mentioned above, with regard to KCl or reserpine-induced tracer depletion mechanisms. High concentration of KCl has been applied as a simulant of electrical field stimulation that enhances cardiac LMI1195 washout significantly in the isolated rabbit heart . Reserpine can also deplete catecholamines (in this case, 18F-LMI1195 that presumably mimics neurotransmitter) from storage vesicles . By accomplishing this study, it might be possible and prove necessary to investigate the likely drug-tracer competition and to compare the different tracer uptake behavior and mechanism details. The conclusions achieved from the results will serve as a useful guidance for future clinical assessment.
18F-LMI1195 was synthesized and purified as described in the literature . The radiochemical purity of the final product was greater than 95% with a specific radioactivity more than 10 GBq/μmol. 131I-MIBG was purchased from GE Healthcare (Freiburg im Breisgau, Germany) and used within 2 h after calibration time. 131I-MIBG was chosen instead of 123I-MIBG due to its relative longer half-life, which is convenient for research purposes and financial reasons.
Both PC12 cells (adrenal gland pheochromocytoma from rat) and SK-N-SH cells (human neural cells from Caucasian neuroblastoma) were purchased from Sigma-Aldrich (Sigma-Aldrich Chemie GmbH, Munich, Germany) and were cultivated at 37 °C and 5% CO2. PC12 cells were grown in a Roswell Park Memorial Institute medium with 2 mM glutamine, 5% fetal bovine serum (FBS), and 10% horse serum. SK-N-SH cells were grown in MEM medium with 2 mM glutamine and 10% FBS. The cells were first grown in 75-cm2 flasks with type IV collagen coating, in which the cells would be adherent. One day prior to release assay, they were transferred to 12-well plates with 1 mL volume per well and 2 × 105/mL density.
Firstly, cells were incubated with high concentration KCl (100 mM) for 10, 20, and 30 min. The total protein concentrations after incubation were compared with control groups using only HEPES buffered saline (HBS) buffer (cf. Additional file 1) to insure the cell viability. No statistical difference could be concluded from these two groups. Therefore, this incubation condition was used for the following high concentration KCl induction study.
The culture medium was removed and the cells were washed with the medium. Cells were first incubated with radiotracers in a solution containing both 18F-LMI1195 (300 kBq) and 131I-MIBG (37 kBq) at 37 °C for 120 min. After incubation, the cells were washed twice with warmed HBS buffer. One milliliter of HBS buffer was added again followed with 5 min incubation before removal. Then, cells were treated with HBS (with or without Ca2+) or 100 mM high KCl buffer (with or without Ca2+) for 10, 20, and 30 min. After the treatment, the buffer was collected as the extracellular fraction. Cells were washed twice with ice-cold phosphate buffered saline (PBS) and solubilized in 0.1 N NaOH. Radioactivity in each sample was measured using a gamma counter using differential energy windows (± 20%) for 18F and 131I (FH412; Frieseke & Höpfner, Erlangen, Germany).
Tracer loadings were performed in analogy to the abovementioned KCl study. Cells were incubated with radiotracers in a solution containing both 18F-LMI1195 (300 kBq) and 131I-MIBG (37 kBq) at 37 °C for 120 min. After the incubation period, cells were washed twice with warmed medium, followed by 5 min incubation with medium. Afterwards, cells were treated with a reserpine solution at final concentrations of 50 nM for PC12 cells and 5 μM for SK-N-SH cells for 10, 20, or 30 min, respectively, because it is known that PC12 cells are sensitive to reserpine-induced depletion, whereas a much higher concentration of reserpine is applied to SK-N-SH cells because of its dramatically lower storage capacity . The incubation buffer was collected followed by double washing with ice-cold PBS. The cells were then solubilized in 0.1 N NaOH, and the cell lysate was collected. Radioactivity of each sample was measured using a gamma counter. Nonspecific uptake was measured in the presence of 10 μM of the selective NET inhibitor desipramine, and specific uptake was calculated by subtracting nonspecific radioactivity from total counts.
in which release counts are defined as counts bound to extracellular buffer after release stimulation. Total counts are the counts bound to cell lysate after the tracer uptake period (including the washing process). To exclude non-specific binding or uptake (which does not contribute to release after vesicular turnover), non-specific uptake was determined in the presence of 10 μM desipramine and subtracted from total uptake.
All experimental data are presented as mean ± SD, with individual numbers measured in triplicate in experiments performed on 2–3 separate days. Statistical comparison of uptake/release ratios between two groups was performed by Student's t test, where p values of less than 0.05 were considered statistically significant. Data were analyzed by analysis of variance (ANOVA) when multiple groups were compared. Statistical analysis was performed on GraphPad Prism (GraphPad Software, Inc., La Jolla, USA).
Treatment of PC12 cells with high concentration KCl buffer induced robust tracer depletion of both 18F-LMI1195 and 131I-MIBG in a time-dependent manner, leading to 88 ± 4% of 18F-LMI1195 and 70 ± 2% of 131I-MIBG total uptake released from cells (p < 0.001, vs. untreated controls, Fig. 1a). In contrast, KCl did not produce an obvious release of either 18F-LMI1195 or 131I-MIBG in SK-N-SH cells and demonstrated similar retention indices as controls (Fig. 1b).
Tracer depletion in PC12 cells 30 min after treatment with high concentration KCl could be overturned by using Ca2+-free buffer containing ethylenediaminetetraacetic acid (EDTA) (Fig. 2). The release index (as percentage of tracer released from cells after certain treatment) of 18F-LMI1195 decreased from 71 ± 4% (100 mM KCl) to 16 ± 7% (100 mM KCl + EDTA). By investigating 131I-MIBG, the same tendency with a decrease from 61 ± 2% (100 mM KCl) to 15 ± 4% (100 mM KCl + EDTA) was observed (p < 0.005, respectively).
The release of 18F-LMI1195 from PC12 cells by exposure to reserpine was time-dependent and reached significant differences after 30 min of treatment. This result is in accordance with our findings for 131I-MIBG (Fig. 3a). LMI1195 uptake reached a significant difference (p < 0.001) after 30 min of reserpine exposure with only 68 ± 3% left (vs. 80 ± 2% in controls). A similar pattern of tracer kinetics was confirmed using 131I-MIBG after reserpine exposure with retention of 65 ± 7% for the reserpine-treated group versus 85 ± 3% for the control group (p < 0.001). Applying the same protocol on SK-N-SH cells (vesicle-poor), 88 ± 2% retention of 18F-LMI1195 and 87 ± 2% of 131I-MIBG in the cells were recorded. However, no statistical difference was reached either for 18F-LMI1195 or for 131I-MIBG (Fig. 3b). Co-exposing the preloaded PC12 cells to both reserpine and the NET blocker desipramine, the tracer release showed a similar pattern to using reserpine alone with significant differences after 30 min of treatment (Fig. 3a vs. Fig. 4).
In summary, high concentration KCl and reserpine could enhance 18F-LMI119 washout from storage vesicle-rich PC12 cells. This washout as quantified as tracer releasing index could reach a significant difference after 30 min of treatment. In contrast, such effect could not be observed while using vesicle-poor SK-N-SH cells. As a golden reference, similar kinetics after KCl or reserpine treatment were also achieved using 131I-MIBG in the same cell lines. Furthermore, high concentration KCl exposure-induced tracer release was Ca2+ dependent as confirmed by suppressing the effect using calcium chelator EDTA and Ca2+-free buffer.
Several tracers sharing similarities in their benzylguanidine structure were designed to compensate for the disadvantages of the clinically used SPECT tracer MIBG. They all represent similarities to MIBG in order to achieve comparable in vitro intracellular retention and in vivo distribution properties . Among them, 18F-LMI1195 is so far the best examined 18F-labeled PET tracer and has successfully proceeded with a clinical phase I trial . In addition to the current literatures [5, 8, 9, 15], our research group has also performed a number of investigations with 18F-LMI1195 using animal models and ex vivo systems [11, 16, 17]. A further understanding of the properties of 18F-LMI1195 and its performance at a subcellular and molecular level is still of importance for its clinical application.
Therefore, we investigated the storage mechanism and depletion kinetics of LMI1195 on both rat pheochromocytoma PC12 and human neuroblastoma SK-N-SH cells, using 131I-MIBG as a comparator. The former cell line is rich of storage vesicles that could retain either the physiological neurotransmitter norepinephrine or radioactive tracers with analogous structures, whereas the SK-N-SH cells are poor of such secretory vesicles, and therefore, the taken-up tracers can only be stored in cytoplasm or mitochondria . All cells were first preloaded with both tracers to reach equilibrium and thereafter were treated with either high concentration KCl buffer or reserpine in order to trigger the depletion of preloaded radiotracers.
As shown in Fig. 1, depolarization of PC12 cells caused by stimulation of high concentration KCl buffer evoked apparent tracer release, with approximately 60–70% depletion of additional 18F-LMI1195 or 131I-MIBG from the cells. By applying high concentration KCl to neuronal cells, Blaustein has proposed that neurotransmitter release from the nerve terminal is caused by Ca2+ influx via voltage-gated calcium channels . Therefore, when using either Ca2+-free KCl buffer with Ca2+ chelator ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid (EGTA) or calcium channel blocker nifedipine, Araujo et al. further verified the suppression of norepinephrine release . Similar conclusions were also drawn by Mandela et al. yielding that norepinephrine depletion is dependent on extracellular Ca2+ and could be fully suppressed by EDTA . Thus, as expected, the outcome of exposing cells to Ca2+-free high KCl buffer containing EDTA lead to comparable findings in our study with a diminished release effect (Fig. 2).
This result attained from high KCl induction is consistent with the conclusion achieved from our research group using isolated rabbit hearts, in which the electrical provocation evoked enhanced tracer release . Electrical field stimulation is known to induce norepinephrine overflow by releasing storage vesicles . Since we could measure the radioactivity in the whole heart, including neuronal cells and myocytes, it was suggested that 18F-LMI1195 was taken up by the cells and stored within the vesicles . In addition to our previous findings, we further confirmed this distinct uptake, storage, and release characteristics by using an in vitro assay.
As a human neuroblastoma cell line, SK-N-SH also expresses NET on the plasma membrane  and they are able to transport either 131I-MIBG or 18F-LMI1195 into cells. However, due to the shortage of storage vesicles, no apparent release of stored tracers could be observed after the application of high KCl buffer compared to controls (Fig. 1b). The response of high KCl-leading tracer release compared with the control group is of utmost importance: Since no statistical difference could be observed between both groups, a robust conclusion can be derived from the setup of our experiment.
Reserpine is known for its potential to release norepinephrine from synaptic nerve cells by triggering the exocytosis of storage vesicles . In this study, reserpine induced significant tracer release after 30 min of its application to vesicle-rich PC12 cells (Fig. 3), whereas such an effect was not observed in SK-N-SH cells, which is in accordance with the conclusion drawn by Smets et al. from a reserpine-induced MIBG depletion study . Due to the deficiency of storage vesicles in SK-N-SH cells, no clear tracer overflow, either with 18F-LMI1195 or 131I-MIBG, could be observed. The efflux of tracers from SK-N-SH cells may be only due to slow passive diffusion. The current study of using either high concentration KCl or reserpine is the opposite way as the results achieved from rabbit heart , in which pretreatment of desipramine was followed by tracer injection (Fig. 5). Firstly, this in vivo study provided the first proof of successfully prohibiting the uptake of tracer into storage vesicles by using desipramine. Secondly, the in vitro cell study demonstrated the clear depletion mechanism of an already taken-up tracer in the storage vesicles. By comparing the two methods (high concentration KCl and reserpine), it was revealed that the application of these exogenous radioactive sympathetic nerve tracers apparently mimics the physiological neurotransmitter norepinephrine turnover quite well, including transporter-mediated uptake as well as modes of storage and exocytosis (Fig. 6). Integrating our previous animal study (Fig. 5) and ex vivo results [11, 16, 17] with the present in vitro findings, the intracellular behavior of 18F-LMI1195 is analogous to its SPECT counterpart MIBG and the neurotransmitter norepinephrine.
Similar to high KCl-induced exocytosis, reserpine-mediated 18F-LMI1195 release is also Ca2+ dependent. Mandela et al. have investigated and reported how reserpine influences NET in a non-competitive manner by Ca2+ dependency and how it interferes with the interaction between NET and norepinephrine storage vesicles. Strikingly, it was revealed that reserpine induces a non-competitive inhibition of norepinephrine uptake in PC12 cells . This effect requires the presence of vesicular monoamine transporter (VMAT) and storage/secretory vesicles, which explains the finding for exposure to reserpine alone and reserpine/desipramine-induced tracer release—a demonstration of analogous uptake and efflux mechanisms associated with the benzylguanidine structure common to both tracers (Fig. 4). By contrast, as demonstrated previously, cardiac retention of 11C-hydroxyephedrine (11C-HED) is mediated through a continuous cyclical mode of release (diffusion out) and reuptake via NET from the nerve terminal [11, 16]. 11C-HED showed enhanced washout from both in vivo and isolated perfused rabbit heart after desipramine chase. On the other hand, 18F-LMI1195 and MIBG are not sensitive to a NET inhibitor chase protocol in an in vivo setting, which was imitated in the present in vitro study by adding desipramine while incubating with reserpine (Fig. 4). Therefore, on a subcellular level, a stable vesicle-storing mechanism mimicking physiological norepinephrine turnover was corroborated.
It should be mentioned that in addition to the application of these NET tracers in cardiac diseases, there are many potential applications in tumor diagnosis . 123I-MIBG imaging had been used in the evaluation of neuroblastoma for years . 18F-LMI1195 would also be available because of their structural and property similarities in NET imaging: A previous study of high and specific accumulation of LMI1195 in pheochromocytomas has already made the first attempt in proving this potential .
Our study demonstrated the subcellular and molecular uptake and release mechanism of the novel sympathetic nerve PET tracer 18F-LMI1195. These findings are analogous to findings for the structurally related and widely used SPECT predecessor MIBG. Both high concentration KCl and reserpine induce the depletion of 18F-LMI1195. The proposed mechanism of vesicle storage and release is consistent with the conclusions suggested from previous studies using both ex vivo isolated perfused and in vivo rabbit hearts. To sum up, we herein demonstrated that 18F-LMI1195 is a promising tracer for visualizing the cardiac innervation by mimicking the physiologic neurotransmitter norepinephrine. It can provide similar properties as MIBG in a clinical setting along with the advantages of 18F-labeling and PET imaging technology.
This study was funded by the German Research Council (DFG grant CH 1516/2-1 and HI 1789/3-3) and the Competence Network of Heart Failure funded by the Integrated Research and Treatment Center (IFB) of the Federal Ministry of Education and Research (BMBF). This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement. This publication was funded by the German Research Foundation (DFG) and the University of Würzburg in the funding program Open Access Publishing.
XC, RAW, and TH designed the study, wrote the manuscript, and researched the data. XC, RAW, CL, NN, and MH performed the analysis. MSJ, SR, and TH aided in drafting the manuscript and revised it critically for important intellectual content. All authors read and approved the final manuscript.


text:
Mohamad Alaa Terkawi, DVM, Ph.D.
Department of Orthopaedic Surgery, Faculty of Medicine, Hokkaido University
Research keywords:
Innate Immune Cells, Inflammatory and Osteolytic Responses, Loosening of Implants
Hokkaido University Unit
Jian Ping Gong, Ph.D.
Tomoyasu Aizawa, Ph.D.
Makoto Demura, Ph.D.
Hisashi Haga, Ph.D.
Kuniharu Ijiro, Ph.D.
Seiichiro Ishihara, Ph.D.
Norimasa Iwasaki, M.D., Ph.D.
Takashi Kikukawa, Ph.D.
Daniel R. King, Ph.D.
Eiji Kondo, M.D., Ph.D.
Hiroyuki Kumeta, Ph.D.
Takayuki Kurokawa, Ph.D.
Hideyuki Mitomo, Ph.D.
Toshiyuki Nakagaki, Ph.D.
Tasuku Nakajima, Ph.D.
Yukinori Nishigami, Ph.D.
Takayuki Nonoyama, Ph.D.
Tomohiro Onodera, M.D., Ph.D.
Katsuhiko Sato, Ph.D.
Jun Suzuka, Ph.D.
Masahiko Takahata, M.D., Ph.D.
Shinya Tanaka, M.D., Ph.D.
Takashi Tsukamoto, Ph.D.
Masumi Tsuda, Ph.D.
Kazunori Yasuda, M. D., Ph.D.
Yusuke Yonamine, Ph.D.
Lei Wang, Ph.D.
France Unit
Costantino Creton, Ph.D.
Dominique Hourdet, Ph.D.
Xueyu Li, Ph.D
Anke Lindner, Ph.D.
Alba Marcellan, Ph.D.
Cécile Monteux, Ph.D.
Tetsuharu Narita, Ph.D.
Thomas Salez, Ph.D.
Yanan Ye, Ph.D.
Dong Shi, Ph.D.
U.S. Unit
Wei Cui, Ph.D.
Michael Rubinstein, Ph.D.
Stephen Craig, Ph.D.
Jan Genzer, Ph.D.
Wei Hong, Ph.D.
Chung-Yuen Hui, Ph.D.
Tsutomu Indei, Ph.D.


text:
William McKeon 1906
HomeVoyagesWilliam McKeon 1906
Coincidently, another account of a similar journey taken in 1906, appeared in The Fruitful Years: a cavalcade of memories, the autobiography of New Zealand architect, William John McKeon, published in 1971. In Chapter Three of McKeon's book, the then young traveller's experience is described:
'In 1906 my father decided that we should have a holiday in Australia, and it was arranged that my mother, my sister and myself should go over first and that he would follow later and bring us home. Needless to say, terrific excitement prevailed. To a ten-year-old boy, the prospect of a trip in a big ship was irresistible. I was already keen on reading, and sea stories were my favourites.
After an orgy of packing, tearful farewells to my father and old Bob, the dog, we eventually set sail in the old Wimmera, a small Huddart Parker ship, later to be lost with all hands [sic] during the war years. We left at sunset on a beautiful evening and I can well remember the delight I felt when I saw the open sea in Cook Strait, the blue rollers and white horses of a heavy swell. Alas! My young enthusiasm was soon damped. I had partaken of a couple of oranges on boarding the ship, and apparently oranges do not have the effect of warding off seasickness. I was horribly ill, and after hanging on to the rail until the worst was over, I staggered to the cabin and turned in, not caring whether I lived or died.
However, youth is a resilient animal and by the morning I was feeling quite fit again, and was soon on deck watching the green hills of Lyttelton slide by as the ship steamed up the harbour. We spend a day at Lyttelton and then sailed down the coast to Port Chalmers and Dunedin, our final call being Bluff, a bleak and open port at the extremity of the South Island.
It was customary in those days for several of the inter-colonial steamers to make a call at Milford Sound before proceeding across the Tasman to Hobart, and it was our good fortune to strike one of these trips. It was an experience I shall never forget. After leaving Bluff [Monday 5 March 1906], we sailed up the West Coast and arrived off the entrance to Milford Sound early in the morning. There was considerable low cloud and fog and some doubt was expressed as to whether we should go in or not. However, after we had sailed slowly up and down for an hour or so, the fog lifted and we steamed slowly through the narrow entrance.
It would take a more eloquent pen than mine to describe the breath-taking beauty of these southern fiords with their precipitous sides, bush-clad to the water line; of the incredible glassy smoothness of the deep green water and the thundering cataracts hurtling down the mountain sides to fan out in snowy foam on the surface. As we moved up the Sound, the passengers assembled on deck stood silent and awestruck. Quite suddenly the walls of vapour, high up on the mountain sides, seemed to thin out, and there, in all its glorious beauty, stood the snowy summit of Mitre Peak, over seven thousand feet above the level of the Sound. Its sharp pinnacle, gold where the sun caught it, and misty blue on the shadowed side, seemed to be suspended in air as it towered above the curtain of mist. An unforgettable sight.
One of the deck hands brought a rifle up on deck and fired it in the air. The sharp crack of its report was followed by thunderous echoes, deepening in sound and volume as they were hurled back and forth between the craggy walls until they died to a murmur like distant thunder. Then the ship's gong was beaten, and finally the Captain gave three short blasts on the siren. The cacophony of sound which grew from this demonstration was incredible in its volume and variety.
Scarcely moving, the ship proceeded up the Sound, while all the time fresh beauties unfolded themselves. The sun had not yet broken through the mist, but there was considerably more light than when we had entered and the lovely greens of the dense foliage showed up in sharper contrast. A thunderous warning became apparent and as we rounded a blunt headland a wonderful sight was revealed. The might Bowen Falls ("a river flung down mountain side") now showed up in all their majestic beauty—a vast column of water over a thousand feet from where it leaves the mountain-side until it plunges into the deep waters of the Sound. Its thunder echoes and re-echoes in this primaeval gorge and we stood spellbound as we watched.
Donald Sutherland.
Detail from a magic lantern slide. Author's Collection.
Far up on the waters of the Sound, a tiny speck appeared. All glasses were levelled at it and speck resolved itself into a boat propelled by a solitary oarsman. As we were still moving slowly towards him it did not take long before he was alongside the lowered gangway, and as he tied his boat up and came aboard my memory recalls a broad-shouldered man clad in old faded trousers and shirt, a felt hat on his head. His hair and bushy beard were reddish and streaked with grey and his eyes clear and blue-grey.
Such was Donald Sutherland, Scottish hermit, who lived alone in the small accommodation house at the head of the Sound, accompanied only by his faithful friend, one "John O' Groats", a big Airedale who was even now jumping excitedly about in the moored boat. Sutherland married many years later and he and his wife continued to live in this primaeval fortress until his death in 1918. He rarely visited the outside world and spend the best part of his life in this magnificent but lonely area.
Supplies, books and papers were lowered into the boat, and after an interval Sutherland re-appeared, bade farewell to the Captain and climbed down the gangway to his boat and his canine companion. He rowed slowly away, watched by everyone on the ship who had crowded the port side to see him go.
The ship slowly circled round and headed down the Sound towards the open sea. The mist and clouds had come down again and much of the magnificence of the scenery was obscured. The suspended vapour lay in long swathes across the face of the wooded mountains, and soon a steady rain set in and drove us all off the decks to the shelter of our cabins or the dining saloon.
In the few hours we had been in the Sound, things had been happening outside. A southerly gale had sprung up and as soon as we emerged from the calm land-locked waters we plunged into the thick of it. I suppose I have sailed on more stormy seas in later years, but to my boyish imagination, this was a storm of storms. The little Wimmera had a very low freeboard and it seemed that instead of riding the seas, she went right through them. The thunder of the falling water on the deck over our heads and the pounding of the waves against the bow sounded like iron tanks being dashed together. The little vessel literally staggered, as some of the tempestuous waves hit her bows and poured over her decks, and we visualised a rather miserable time for the next few days. We were right. The whole ship was "battened down" and no passengers were allowed on deck. We existed miserably in our cabin and in the dining saloon where, even with the fiddles rigged on the tables and the tablecloths damped, it was impossible to keep a plate or a cup and saucer in position. Every thing felt damp to the touch, and in the confined space below decks the air grew foul and smelly. It was bitterly cold, and in those days there was nothing in the way of a heating system to warm the ship up. However, we endured and did not suffer again from seasickness, despite the storm.
Four days later, we steamed into the quiet water of the harbour of Hobart, and as we thankfully emerged on deck, we saw that our ship bore marks of her strenuous crossing. Her long yellow funnel was white with salt on the forward face, and brown aft, where the heat from the fires had scorched the paintwork. A broken lifeboat and some smashed deck fittings bore witness to the fact that she had been "taking it green" most of the way and we thanked our stars that the worst part of the voyage was over.
It is curious that the Tasman Sea, although only twelve hundred miles across between New Zealand and Australia, is one of the worst stretches of water in the world at times. No doubt this is brought about by the fact that it has its feet in the Antarctic and its head in the tropics. Sufficient to say that cyclonic storms develop with startling suddenness over this area, sometimes at the northerly, sometimes at the southerly end, more frequently in the middle on the trans-Tasman shipping route.
Hobart: Lovely, sleepy town, nestling at the foot of Mount Wellington, whose green slopes soared up to the peculiar fluted rocks near the summit, giving the appearance of the pipes of a gigantic organ. White stone houses and groves of deep green trees and the lovely Derwent River flowing out to the sea…
…On to Melbourne, across a sparkling Bass Strait, playful but not stormy, and to a glorious holiday in the city of my birth.'
McKeon, William J. The Fruitful Years: A Cavalcade of Memories. [Wellington, N.Z.]: [The Author], 1971.
Read on: Daisy Quinlan 1906
© Ralph L. Sanderson 2004-2021


FINALLY the hubbie & I got in at the famous Blue Door Pub!
We went to the St Paul, MN location but, I do hear that a new one opened up in Minneapolis.
We have been trying off and on for 2 years now, the wait was insanely long, we never stuck around long enough to get in.
The place is tiny and you have to wait to get a table for a good long while, but I swear it's so worth it!
Best burgers we have had in a long time!
I had seen this restaurant review for the first time done by Guy Fieri, if you don't know who he is you must not watch the Food Network.
He had the Spam Bites, I thought we had to try these its just so crazy.
Loved them both! Service was excellent too!
I'm a beer girl, they have local beers, I tend to like light beer (subconsciously thinking I will not be gaining much weight drinking it , ya right).
I tried the Lift Bridge Farm Girl, just because I loved the name :) It was a good choice!
Me the original Blucy, a stuffed burger with blue cheese, garlic and angus meat. The buns were for sure from a local bakery too, very soft & fresh. Mouth watering good!
The husband ordered Cajun Blucy & added Jiffy peanut butter a popular choice, he too loved his burger!
We will for sure be visiting the Blue Door Pub again!


text:
7 Reasons Ghostwriters Help Fulfill the Christian Mission
(New York, NY)—If you think Christian books are all still non-fiction, scholarly works written by college professors and ministers, you could not be more wrong. The world of publishing has changed, and many ministries are encouraging members to write with the help of professional ghostwriters.
"The demand for Christian books of all stripes has skyrocketed," says Larry Leichman, co-owner of Arbor Books (http://www.arborbooks.com/), a leading ghostwriting, editing and self-publishing firm. "Many Christians are determined to share the word of God through fiction and children's books but are not writers."
Mr. Leichman's company has seen a growing demand for ghostwriters and editors who specialize in Christian books as many denominations have made it a priority for their members to proselytize through new publishing mediums, such as print-on-demand (POD), e-books, and audio books.
Among the benefits Mr. Leichman sites for ghostwriting a Christian book are his top 7:
1. Evangelism: Written works are still the best way to spread your testimony and the teachings of God, according to Mr. Leichman. Ghostwriters help to polish and shape the message.
2. Examining our lives: Personal memoirs and testimony are powerful tools for bringing a humanity to the face of Christianity.
3. Getting closer to God in your daily lives: Putting thoughts to paper and taking the time to think through your thoughts about God and His works can be a great way to deepen your understanding and connection with Him.
4. Therapy: Let's face it, we all struggle with doubt and tragedy. Writing remains a great way to achieve catharsis.
5. Teaching: Formal settings like churches can intimidate some spiritual seekers. Having a professional book written for the curious among us can help teach Christian tenets.
6. Advice: As a Christian, you are probably asked constantly for spiritual advice. Why not formalize that advice in a written book you can share.
7. Bible study: Scholarly works are still purchased in droves by those seeking to know more about the Christian story.
"Writing is not easy for everyone," says Joel Hochman, co-owner of Arbor Books, "but for Christians it is very important work. Christian publishers are now looking for creative, new ideas and will scour the earth to find good work. A ghostwriter can help ensure quality."
Mr. Hochman points out that some of the hottest Christian books are works of fiction. He points to such top Christian fiction writers as Frank Peretti, William P. Young, D. Shane Burton, Randy Alcorn, Ted Dekker, Samuel White, Shaunti Feldhahn, Jan Karon, Dee Henderson, Janette Oke, Lillian K. Duncan, George MacDonald, Robert Calvert, Tim LaHaye and Jerry Jenkins, Bill Myers, Shane Johnson, and Alton Gansky.
A global company, Arbor Books has worked for years with the Christian community to produce inspiring memoirs, insightful histories, thrilling novels and many other books in this genre. The firm works closely with clients to plan their projects at prices that meet their budgets. Ghostwriting a Christian book generally costs between $3,500 and $19,000, depending upon the length and complexity of the manuscript desired by the client.
Most books can be written in 120 days through interviews with the client via phone calls or e-mails or in person (some clients also opt to provide their ideas via Word documents, audio tapes or videos). As the ghostwriter progresses, work is sent to the client for approval. Completely confidential, only the client's name appears on the finished product, and he or she retains 100 percent of the rights and profits.
Arbor Books ghostwriters have years of experience in writing books with Christians from all walks of life.
Arbor Books' ghostwriters and projects have been published by industry giants such as HarperCollins, Simon & Schuster, Warner Books and Penguin. The firm even features many writers who have written multiple Christians books for both laymen and clergy.
For more information, please visit http://www.arborbooks.com/ or call 1-800-877-2500.
Posted by Arbor Books at 3:14 PM 3 comments: Links to this post
7 Reasons to Ghostwrite Your Memoir Now!
(New York, NY)—Memoirs, life stories, autobiographies, tell-alls, diaries—no matter what you call them, they're a hot trend in publishing. People like talking about themselves as much as others like reading about them.
Everyone, young or old, is a candidate for a memoir; all you need is a story to tell. Retirees, veterans and senior citizens, as well as students, parents and business people all have memoirs inside them. The problem is that many people don't have the time, inclination or ability to write. And that's where a ghostwriter comes in.
"Having a book ghostwritten might be among the most important things a person can do," says Larry Leichman, co-owner of Arbor Books (www.arborbooks.com), a leading ghostwriting, editing and self-publishing firm. "We all want to be remembered, and with the availability of ghostwriting firms and the advancements in self-publishing options, we can almost create our own immortality."
Mr. Leichman points out the main reasons to use a ghostwriter are: speed and expertise. Most people tend to put off projects. By using a ghostwriter, a person can be assured the project gets done and gets done quickly and expertly.
When considering a memoir, there are some things you should ask yourself first:
* Will you be revealing personal secrets you might want to keep hidden?
* Will you be violating secrets about others that might upset relationships or even lead to defamation lawsuits?
* Will you be recalling verifiable facts or just memories that might be open to contradiction or dispute?
In any of the above cases, you can still put it all down on paper and then either include a caveat or edit the more controversial material out of the final manuscript.
A professionally ghostwritten memoir can be compiled by a writer in mere months and can be formatted as a traditional book, an e-book or an audio book. Here are just a few reasons why you should have your book ghostwritten book now:
1. As a gift: A well-done memoir makes a far better holiday gift than a sweater, tie or toaster oven.
2. To give advice: You've learned a lot in your life. Shouldn't you share your hard-won lessons? Your wisdom will help others, especially family and friends, to maximize their life experiences.
3. To contribute to a family tree. Genealogy services have taken off in recent years because Americans are curious about their ancestors. Your account of your life will provide invaluable records for your family.
4. To share your personal insights. A memoir allows you to connect with your audience in a way no other format can. Even close relatives will learn poignant details about your life that might otherwise go unspoken.
5. As therapy. Catharsis is something we all seek when dealing with hardships. A memoir offers a chance for closure and a process through which to deal with regret.
6. To build a legacy. What is the point of your life? If you think that your life isn't worth hearing about, perhaps you have doubts about your purpose or accomplishments. A detailed look back will remind you of the work you've done and the contributions you've made to society.
7. To create a piece of history. A memoir can be a powerful milestone in your life, whether you're a young person or a retiree. What better way to keep track of your feelings and pursuits than in a professionally ghostwritten and bound book?
A global company, Arbor Books has created many compelling, fun and touching memoirs for individuals and families. The firm works closely with clients to plan their projects at prices that meet their budgets.
"Whether the book is for just a few family members or a general audience, we can help you create a unique memoir that makes your story distinctive and memorable," says Joel Hochman, co-owner of Arbor Books. "Ghostwriting a memoir involves more than just putting words on paper. It's about conveying emotion and establishing your identity as an author."
Ghostwriting a memoir generally costs between $3,500 and $25,000, depending upon the length (48 pages vs 400 pages) and complexity of the manuscript desired by the client. Most books can be written in 120 days through interviews with the client via phone calls or e-mails or in person (some clients also opt to provide their ideas via Word documents, audio tapes or videos). As the ghostwriter progresses, work is sent to the client for approval. Completely confidential, only the client's name appears on the finished product, and he or she retains 100 percent of the rights and profits.
Arbor Books' ghostwriters have years of experience in writing memoirs and personal family histories and have covered just about all subgenres including religious, political, corporate, family, gay, immigrant and more.
For more information, please visit _www.arborbooks.com (http://www.arborbooks.com/) or call 1-800-877-2500.
Posted by Arbor Books at 3:13 PM No comments: Links to this post
5 Reasons Environmental Activists Turn to Ghostwriters
(New York, NY)—As oil washes up the coast in the Gulf of Mexico, environmental activists are pushing for tighter legislation to prevent further accidents like the one caused by the sinking of the Deepwater Horizon oil rig. Ghostwritten books could help spread their message.
"Time is of the essence now for environmentalists hoping to spread their message," says Larry Leichman, co-owner of Arbor Books (www.arborbooks.com), a leading ghostwriting, editing and self-publishing firm. "a ghostwriter can help speed the process of writing a book that may shape the future of climate change legislation."
A professionally ghostwritten book can be compiled in months and can be formatted as an e-book or audio book, allowing for electronic disbursement of critical messages. Here are five more reasons why environmentalists should use ghostwriters:
1. No message, no matter how sincere is going to have an effect if it is poorly communicated. Ghostwriters help ensure quality writing.
2. With the help of a ghostwriter, activists can effectively double the manpower researching and disseminating their message.
3. Climate change legislation is making its way through the Senate right now. The debate process could take months so there is still time to publish a book.
4. Mainstream publishers may edit or otherwise change your book, diluting your message. With self-publishing and ghostwriting, you own the work.
5. The environmental message is becoming mainstream, but many are still confused about the facts. You can set the record straight with the help of a ghostwriter.
A global company, Arbor Books has worked for years with the environmentalist and scientific communities to produce non-fiction works, histories, essays and memoirs in this genre. The firm works closely with clients to plan their projects at prices that meet their budgets.
Ghostwriting an environmental book generally costs between $5,000 and $25,000, depending upon the length (48 pages vs 400 pages) and complexity of the manuscript desired by the client. Most books can be written in 120 days through interviews with the client via phone calls or e-mails or in person (some clients also opt to provide their ideas via Word documents, audio tapes or videos). As the ghostwriter progresses, work is sent to the client for approval. Completely confidential, only the client's name appears on the finished product, and he or she retains 100 percent of the rights and profits.
Arbor Books ghostwriters have years of experience in writing books with professionals from all walks of life. Arbor Books' ghostwriters and projects have been published by many mainstream publishing companies.
National Career Award Competition for Literature
Arbor Books to Judge National Society of Arts and Letters Competition
(New York, NY)—Arbor Books, the nation's leading ghostwriting, editing and self-publishing firm, will be a key participant at this year's National Career Award Competition for Literature, organized by the National Society of Arts and Letters.
The competition will be held in Florida from May 20 to 23.
The competition, which is open to short-story authors between the ages of 18 and 33, is part of NSAL's long history of promoting the arts in America. The winners of the competition will be announced on May 22 in Clearwater, Florida, where Arbor Books will be represented by Larry Leichman, co-owner of the company.
"This is a terrific opportunity for aspiring writers," says Mr. Leichman. "Being an NSAL finalist or winner adds crucial cachet and credibility to a writer's query letter or resume, and nowadays that can make all the difference between acceptance and rejection."
Mr. Leichman appeared last year before the Tampa Chapter of the NSAL to deliver a speech on ghostwriting and careers for ghostwriters.
Arbor Books employs nearly 100 ghostwriters who work on various projects and assignments around the world. These writers have been published by mainstream publishers such as St Martin's Press, Random House, Wiley, Baen, HarperCollins, Del Rey, Simon & Schuster, MIRA Books, Scribner, Bantam, Warner Books, Doubleday, Dutton, Tor, Pocketbooks, Pinnacle/Kensington Books, Penguin Putnam and others.
Arbor Books also employs reporters who have worked for some of the top newspapers and magazines in the US, including The New York Times, The New York Post, The Miami Herald, Rolling Stone and others.Arbor Books also employs media tie-in writers who have written books for some of the most popular series in the world: Star Trek, Star Wars, Stargate, Dr. Who, Halo, Warhammer, Jurassic Park and more. Many of Arbor's writers are members of the Horror Writers Association, International Thriller Writers, the Mystery Writers Guild and Science Fiction and Fantasy Writers of America. Some of their writers have been optioned for movies and TV by New Line Cinema, Fox Searchlight and many other production companies.
The top award in the National Career Award Competition is $10,000 and will continue NSAL's longstanding tradition of patronage. NSAL was started in 1944 by a group of American women who first met in the Maryland home of Mollie Davis Nicholson. The NSAL has always been nonpartisan and nonprofit.
"The future of our publishing industry is dependent on organizations like the National Society of Arts and Letters," says Joel Hochman, co-owner of Arbor Books. "Whether they help to open doors, garner publicity or land a job, competitions such as those sponsored by the NSAL are more vital than ever in promoting a writer's career."
A global company, Arbor Books and its ghostwriters have worked for more than a decade with clients both young and old to produce inspiring memoirs, insightful histories, thrilling novels, business books and many others. The firm works closely with clients to plan their projects at prices that meet their budgets. The process is completely confidential--only the client's name appears on the finished product, and he or she retains 100 percent of the book's rights and profits.
Arbor Books' ghostwriters have years of experience in writing books with clients from all walks of life, though Mr. Leichman and Mr. Hochman also help young writers to develop.
Arbor Books to Judge NSAL National Literature Competition
(New York, NY)—Arbor Books, the leading ghostwriting, editing and self-publishing firm in the country, is pleased to announce that it has been selected to help judge this year's National Career Award Competition for Literature, organized by the National Society of Arts and Letters.
"We're honored to be a part of this competition," says Mr. Leichman. "The NSAL has been promoting the arts for more than sixty years and to be asked to take part in their work is a great privilege. Our company employs dozens of young writers, so we know how important development and support can be for them."
"We've been following the work of the NSAL for years," says Joel Hochman, co-owner of Arbor Books. "Their contribution to the American tradition of literature cannot be overstated. Making a living as a writer can be difficult even in the best of times, but with today's economy, these competitions are more vital than ever."
Arbor Books' ghostwriters and projects have been published by many of the publishing industry's giants.
For more information, please visit www.arborbooks.com or call 1-800-877-2500.
7 Reasons Ghostwriters Help Fulfill the Christian ...
5 Reasons Environmental Activists Turn to Ghostwri...
Arbor Books to Judge NSAL National Literature Comp...
Arbor Books
Daniel Hooks
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text:
Time to Crack Down on Erdogan's Turkey — an Opponent, Not an Ally
by James Sinkinson / JNS.org
Turkish President Recep Tayyip Erdogan and his Russian counterpart, Vladimir Putin, shake hands during a news conference, in Moscow, March 5, 2020. Photo: Pavel Golovkin / Pool via Reuters.
JNS.org – The Republic of Turkey used to be known as a bridge between East and West, a shining example of a Muslim-majority liberal democracy. It is a member of NATO, was considered a candidate for European Union membership, and is an important partner because of its geostrategic location.
However, since the election of Recep Tayyip Erdogan as prime minister in 2003, Turkey has abandoned its secular democratic underpinnings and is now seen less as a solution in the region, than as one of its most threatening problems, along with Iran.
The United States, the European Union and the West in general have been extremely patient with Erdogan's Turkey, despite the purging of its judiciary, media, and military, long considered reliable barriers against creeping Islamism.
Nevertheless, Turkey's recent actions demonstrate that it is no longer a friend or ally, but is pursuing what a former senior member of Erdogan's inner circle called "neo-Ottomanism" — a return to its imperial and regional ambitions. These moves are sufficiently contrary to US and Western security interests that it's time to call Turkey to account.
The horrific events this past Shabbat at Congregation Beth Israel in Colleyville, Texas, highlighted once again that there are forces...
Turkey's political closeness to Russia is a major worry for NATO. Its decision to take delivery of next-generation Russian S-400 missile-defense systems is considered a slap in the face of NATO, especially when Western systems were on offer. Many warned against the purchase, saying the systems could gravely compromise NATO defenses by giving Russian technicians access to vital information on the latest American and European fighter aircraft.
Moreover, Turkey has pursued what Cyprus, an EU member, called "illegal expansionist plans" in the Eastern Mediterranean by continually attempting to drill for gas in waters where Cyprus has exclusive economic rights. On many occasions, these exploration vessels were accompanied by warships. Experts have called these activities "acts of piracy" and contrary to international law.
Having long illegally occupied the northern part of Cyprus and violently oppressed its own Kurdish population, Turkey has become increasingly involved in the Syrian civil war in recent years. It has long provided military and diplomatic support for Al-Qaeda affiliate the Nusra Front, which has caused untold atrocities and is considered a terrorist organization by many across the world. While ostensibly claiming it was conducting operations against Islamic State, the Turkish military has repeatedly entered and shelled parts of Syria controlled by Kurds, who fought against Syria's Bashar al-Assad alongside Western forces. One US senator on the Senate Armed Services Committee said last year that the Turkish offensive against Kurds in northern Syria is "on the cusp of genocide."
Erdogan has increasingly become open about his relations with terrorist organizations. He recently and publicly met with Hamas leader Ismail Haniyeh and deputy leader Saleh al-Arouri, both of whom have a $5 million bounty on their heads after being designated as terrorists by the United States.
"President Erdogan's continued outreach to this terrorist organization only serves to isolate Turkey from the international community, harms the interests of the Palestinian people, and undercuts global efforts to prevent terrorist attacks launched from Gaza," the US State Department said in a statement. This comes on the heels of reports that some of the 12 senior Hamas members who are located in Turkey have received Turkish citizenship.
In July, Erdogan formally converted Istanbul's iconic sixth-century Orthodox Christian cathedral Hagia Sophia into a mosque and declared the UNESCO world heritage site open to Muslim worship, hours after the Turkish high court annulled a 1934 decision that had turned it into a museum. This despite repeated calls from international officials and Christian leaders not to take this controversial and explosive step.
One of the most glaring examples of Turkey's turn away from the West and its interests is in its rapidly deteriorating relationship with Israel, which used to be considered an axle of stability and security in the Eastern Mediterranean.
Over the years, Erdogan and his supporters have engaged in antisemitic incitement, directly supported the IHH, a terrorist organization responsible for the violent flotillas to Gaza, and has attacked Israel in international forums. He has been branded an antisemite not infrequently by Israeli officials and organizations like the Simon Wiesenthal Center. Erdogan recently claimed that Jerusalem "is our city" and said that the conversion of Hagia Sophia into a mosque is a first step into "liberating" the al-Aqsa Mosque on the Temple Mount in Jerusalem, Judaism's holiest site.
These are just some of many examples of Turkey's turn away from the West, and its place as a pillar of stability and security in the region. Some, like former US President Barack Obama, believed Erdogan was a loyal partner, regarding him as "a man of principle, and also a man of action." However, even Obama was disillusioned with him by the end of his tenure.
However, few have attempted to exert pressure on Turkey to change direction. They have been worried that by pushing too hard, they will completely lose and alienate it. They are also worried about Turkey's threat to allow for more Middle Eastern refugees to use it as a transit nation to gain access illegally to the European Union. This is a hollow threat, because it has barely acted on this issue up until now, and if anything continues to allow access in the other direction, allowing terrorist sympathizers from Europe to use it as an access point to join with terrorist groups in Syria and Iraq.
Nevertheless, in recent years, Erdogan's Turkey has completely recalibrated its position vis-à-vis the West and even its former partners in the region.
Thus, it is incumbent on the United States, members of NATO, and other interested nations to exert pressure economically, geostrategically, and diplomatically, to convince Erdogan that he has more to lose than gain from his behavior. They must show that they will not be bowed by threats from Turkey and its role in conflicts, such as in Libya, to gain leverage.
Turkey is vulnerable because of its dire economic situation. The European Union buys more than half of Turkey's exports and owns more than two-thirds of its foreign direct investment. Late last year, President Trump signed an executive order sanctioning Turkish officials, hiking tariffs on Turkish steel up to 50 percent, and "immediately" halting trade negotiations with the country. It now dangles the possibility of a free trade deal with Turkey.
Turkey's allies Russia, China and Iran simply cannot compete with this reality, and Erdogan knows it. That is why the European Union and the United States must condition their assistance, trade, and alliance on Turkey's changing its behavior. It has largely only seen the carrot — if it continues its misdeeds, Erdogan must also feel the stick.
James Sinkinson is president of Facts and Logic About the Middle East (FLAME), which publishes educational messages to correct lies and misperceptions about Israel and its relationship to the United States.
The opinions presented by Algemeiner bloggers are solely theirs and do not represent those of The Algemeiner, its publishers or editors. If you would like to share your views with a blog post on The Algemeiner, please be in touch through our Contact page.


All equipment facilities installed on Samsung R528/R728 are listed below. In order to facilitate the search for the necessary driver, choose one of the Search methods: either by Device Name (by clicking on a particular item, i.e. Mobile Intel(R) 4 Series Express Chipset Family) or by Device ID (i.e. PCI\VEN_8086&DEV_2A42).
Samsung R528/R728 laptop features 233 devices.


text:
package com.tempname.keeper.activities;

import android.app.Activity;
import android.content.Intent;
import android.os.Bundle;
import android.view.View;
import android.widget.EditText;

import com.tempname.keeper.R;
import com.tempname.keeper.data.Data;
import com.tempname.keeper.data.WebErrorListener;
import com.tempname.keeper.data.WebResponseListener;
import com.tempname.keeper.util.Notification;

import org.json.JSONException;
import org.json.JSONObject;

public class LoginActivity extends Activity {

    private final Activity self = this;

    @Override
    protected void onCreate(Bundle savedInstanceState) {
        super.onCreate(savedInstanceState);
        setContentView(R.layout.activity_login);
    }

    public void login(View view) {
        String username = ((EditText) findViewById(R.id.usernameInput)).getText().toString();
        String password = ((EditText) findViewById(R.id.passwordInput)).getText().toString();

        Data.getInstance().authenticate(username, password,
                new WebResponseListener() {
                    @Override
                    public void onResponse(JSONObject response) throws JSONException {
                        Intent intent = new Intent(self, MainScreenActivity.class);
                        intent.putExtra("AccountData", response.toString());
                        self.startActivity(intent);
                        self.setResult(RESULT_OK);
                        self.finish();
                    }
                }, new WebErrorListener() {
                    @Override
                    public void onError(JSONObject error) throws JSONException {
                        Notification.displayError(self, error.getString("message"));
                    }
                });
    }
}

redpajama_set_name: RedPajamaGithub


text:
Gaddafi's Killer Virgins
Next month, the guy known as the "Guide of the First of September Great Revolution of the Socialist People's Libyan Arab Jamahiriya" will be making his first-ever appearance on U.S. soil.
The world's third-longest-serving national leader has come a long way since the 1980s, when the Americans bombed the bejesus out of his abode.
That's right, folks, Muammar al-Gaddafi is about to make his first diplomatic trip to American shores.
ROTI previously reported on Gaddafi's penchant to bring a gigantic tent with him where ever he goes.
However, I recently learned that Gaddafi's traveling circus has a security service that is exceptional and unique:
The conventional treatment for a visiting head of state is five-star accommodation and a fleet of limousines.
This one brought his own tent and camel.
Security might consist of some hefty male bodygaurds and strategically-placed marksmen.
This VIP brought 30 blue-uniformed females, all supposedly virgins.
Don't be deceived: The Libyan leader's female guards are trained to kill.
Few of the orthodoxies of a state visit remained unchallenged as Colonel Muammar Gaddafi breezed into Paris in his Bedouin robes yesterday.
His 400-strong entourage arrived on no fewer than five planes before heading to the Hotel de Marigny, where the Libyan leader will pitch his heated tent in the grounds.
He was said to be bringing a Saharan camel with him in order to "greet visitors in the true desert tradition".
How hilarious is this picture of Sarkozy? Have you noticed that he is always around when world leaders are up to sketchy business? First he joined Obama in peeping some Brazilian booty, now he's hanging out with Gaddafi and his killer virgin posse.
Next thing you know, Gaddafi takes his killer virgins tour to the USA.
Coincidence?? I think not.
"Did you see those killer virgins, bro?!
I was so freaking stoked when they came to visit!"
Any conversation about shady world leaders has to include Italy's lecherous Silvio Berlusconi, and here is a delightful Daily Mail report on Gaddafi's visit to Rome:
Rome has had its fair share of triumphant parades by bizarre tyrants in its long history.
And the ageing Libyan leader Colonel Muammar Gaddafi's arrival on Monday ranked alongside any grotesque ceremony staged by Caligula or Nero.
It is easy to see why Italy's Left-wing opposition denounced the dictator's reception by Italian premier Silvio Berlusconi as a 'rock star welcome'.
Gaddafi's arrived in Rome with a 300-strong retinue on three Airbuses. As ever, he brought with him a giant Bedouin tent, which was erected in a park in the centre of the city and where he was to stay and conduct business.
There was no immediate sign of the camel he took on a visit to Paris in 2007 when he pitched his tent in the grounds of a five-star hotel.
With gelled and carefully dyed hair, the Colonel was made up to look like a cross between Michael Jackson and the deranged music mogul murderer Phil Spector.
Pinned to his chest was a large photograph of a Libyan resistance leader being hanged by Italian colonialists in 1931.
Although with his peaked cap, red flashes, gold braid epaulettes and an array of military decorations that resembled a Dulux colour chart, he turned out in a uniform that Italy's last tyrant, fascist leader Benito Mussolini, would have killed for.
But it was the gun-toting female bodyguards in their khaki uniforms and red berets in the 67-year old dictator's entourage, girls who wear Kalashnikovs like Gucci fashion accessories, who stole the show.
Gaddafi is one of the maddest dictators on Earth and he doesn't like being upstaged – unless it's by this 40-strong troupe of well-equipped, all-virgin minders.
The Rome visit provoked this amusing coverage of the killer virgins by News of the World:
The dictator, who calls himself a pioneer of 'Islamic socialism', doesn't let his female security detail hide their charms under a burqa.
The all female bodyguards, along with their khaki uniforms and red berets, wear lipstick, jewellery, and even high heels – but are trained in armed combat.
All 40 guards are virgins, and he insists they remain so.
Gaddafi's girls have become an internet sensation with websites dedicated to them.
Not that Gaddafi is likely to mind the furore – he once famously passed wind the whole way through an interview with John Simpson.
Bizarrely, Gaddafi claims they are a symbol of his belief in female emancipation. "Women should be trained for combat, so that they do not become easy prey for their enemies," he is reported to have said.
When I was growing up in the 80s, Gaddafi was one of the ultimate bad guys. Reagan was always trying to kill him and he was usually sponsoring some kind of vile terrorist mess.
After September 11th, he got pretty freaked out by the GWOT and all of a sudden changed his ways, I guess.
Next thing you know, Gaddafi has transformed from wicked enemy of freedom into one of the world's most wacky leaders, seemingly harmless and awesomely entertaining.
Many are protesting Gaddafi's U.S. visit, outraged at his past support for terrorist killers and trying to deny him landing spots for his Bedouin tent.
An Orthodox rabbi who lives next to the Libyan estate said he plans to gather local residents at his home Sunday for a protest against the possible Gaddafi visit.
"Gaddafi has shown his true colors," Shmuley Boteach said. "He has welcomed al-Megrahi as an icon, when this is a cowardly mass murderer."
Haters…please give it a rest.
I think Shmuley Boteach is just jealous that HE doesn't have virgin bodyguards with which to impress powerful world leaders…
Filed under Smiles Tagged with BERLUSCONI, GADDAFI, GWOT, KILLER VIRGINS, OBAMA, SARKOZY


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text:
Sunrise City: Boom Town to Ghost Town, Alaska - Signs of History on Waymarking.com
Sunrise City: Boom Town to Ghost Town, Alaska
in Signs of History
Posted by: Queens Blessing
N 60° 55.729 W 149° 20.809
6V E 372805 N 6757136
Quick Description: This sign provides the history of the Ghost Town called Sunrise.
Location: Alaska, United States
Waymark Code: WM9BEQ
Published By: Sign Historians Category Managers
The sign reads:
"Sunrise City: Boom Town to Ghost Town
Established in 1895, the community at the mouth of Sixmile Creek took less than two years to grow into the largest town in the Cook Inlet region. A decade later, the population had dwindled and the gold rush town of Sunrise entered its sunset years.
A Dozen Cabins
Two of the first propectors on Sixmile, A.J. Mills and George Donaldson, set up camp near the mouth of the creek in June 1895. The camp grew to a dozen log cabins that summer. Three mountain peaks tower over the town site. The miners noticed the sun rose above one peak, disappeared, then rose above the rest. This continued until the sun had risen above all tree peaks, one after another. This phenomemon led the miners to name the came Sunrise.
A Bustling Supply Center
A gold rush in 1896 brought 1,500 men and women to Sixmile Creek and it tributaries. Sunrise, overrun with stampeders, became a tent city and the area's supply hub. One visitor said it looked "like an army encampment." By 1898, the town ot 800 boasted three general stores, three saloons, a billiard hall, a restaurant, a post office, a hotel and a community hall.
From Boom to Bust
Gold strikes elsewhere lured away miners and by 1906 the population of Sunrise had declined to 75. Merchants followed the miners, fires destroyed several businesses and other buildings were torn down and used for firewood. The post office closed in 1918. Michael Connolly, the recorder for the town and the mining district in the early years, was the last resident of Sunrise. When he drowned in 1939, the town died with him. Today, several collasped buildings and a few foundations are all that remain of this gold rush town site."
Group that erected the marker: State of Alaska
URL of a web site with more information about the history mentioned on the sign: [Web Link]
Address of where the marker is located. Approximate if necessary:
Turnagain Arm car pull-out
Seward Highway
Girdwood, AK USA
Take a picture of the marker, preferably including yourself or your GPSr in the photo. A very detailed description of your visit may be substituted for a photo. In any case please provide a description of your visit. A description of only "Visited" or "Saw it while on vacation" by anyone other than the person creating the waymark may be deleted by the waymark owner or the category officers.
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