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Q: exporting figure to eps file I am trying to export a figure which includes highlighting of regions - something like this: Highlight parts of matlab plot. Unfortunately, when I export the figures to .eps files the size is of the order of ~10 MB... Thus, when I include them in a tex file, the quality is severely degraded.  As expected this problem seems to occur due to the use of the  area function for the highlighting. Is there any workaround on this?

A: You have transparency in your plot which requires the renderer to be OpenGL which causes any EPS to not really be vector graphics but rather bitmaps coerced in some strange way. This is why the file size is much larger than what you would expect for vector graphics. If you open the resulting EPS file with an external editor (Illustrator, Inkscape, etc.) you will see what I am talking about. As a side-note,  transparency isn't technically supported in EPS files.
Your options are really to

*

*Save your figures as something else such as TIFF or PNG

*You could try saving the figure as an EPS using export_fig from the file exchange but you will likely still have the same issue.

*Turn off transparency, save to an EPS, and use Illustrator or an external program to change the transparency and try to save as an EPS file and see if you get better results.


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Green Day Plans To Celebrate 25 Years Of 'Dookie' With AMAs Performance
posted by Katrina Nattress - Nov 19, 2019
Green Day's Dookie turned 25 this year, and though the band reflected on its seminal album on its anniversary in February, Billie Joe Armstrong, Tré Cool and Mike Dirnt aren't done celebrating. As Billboard reports, the punk rockers plan to honor their 1994 record this weekend at the American Music Awards with a performance of their classic hit "Basket Case," as well as their new single "Father of All..."
Green Day join an already stacked list of performers that includes a special performance with Ozzy Osbourne, Post Malone, and Travis Scott, and Shania Twain playing a medley of her greatest hits. Christina Aguilera, A Great Big World, the Jonas Brothers, Camila Cabello, Billie Eilish, Selena Gomez, Lizzo, Dua Lipa, Kesha featuring Big Freedia, Thomas Rhett, and Artist of the Decade recipient Taylor Swift are all also set to perform.
The 2019 American Music Awards will air live from the Microsoft Theater in Los Angeles on November 24 at 8 p.m. ET on ABC. Check out a full list of nominees here and Green Day's performance announcement below.
Green Day are gearing up to release their new album Father of All... in February, then head out on the Hella Mega Tour with Weezer and Fall Out Boy. Tickets to the tour are available now.

redpajama_set_name: RedPajamaCommonCrawl


Filmmaker Forum > Main > Filmmakers > Optioned -- for $200,000?
View Full Version : Optioned -- for $200,000?
Last week a Hollywood executive producer emailed me to ask if my script was sold or optioned. When I told her, no, she offered to option it. She went on to say it could be filmed as early as next fall and that I would receive a payment of $200,000 as early as this January. In my haste and excitement I didn't establish if she meant an option payment or the full price of the script. I'm new at this and had all but forgotten the script -- in other words, I wasn't ready for the call.
When a producer has the ability to raise $100 million dollars, a $200,000 option payment makes sense. If nothing else, it shows the millionaires and billionaires you're committed to the script -- you believe in it. Honestly, how do you ask someone like, say, Richard Branson, to commit $100 mil to your movie if you won't commit a measly $200,000? How do you convince him the script will generate $200 million at the box office?
Secondly, an usually high option payment on the front end removes the screenwriter from the back end -- no points from gross receipts have to be promised. The writer gets screwed -- but he's screwing himself! One percent of $100 million is a million bucks. Two percent is two million bucks. What writer without a track record wouldn't jump at a $200,000 option payment even if it means no points on the back end? What agent or lawyer wouldn't?
The point is simply this -- at this level of play there's compelling reason to give such a large option payment.
Finally, at this level of play you're dealing with people who know a $100 million dollar script when they see one. These are not agents, lawyers, screenwriting pundits who've never sold a script; these are world class poker players -- they know how to size up a script; they know how to play their hand.
In other words, we're not talking about 99% of producers. We're talking about the 1% who -- because of their track record -- can pick up the phone and have a $100 mil check Fed-exed to their office the next day.
If this is what I lucked into, all the rules go out the window.
Absolutely -- in fact the contract is due tomorrow. I'll post it as soon as it comes in.
All I'd say (as I'm out of my league on this) is have a good entertainment attorney review any contract before you sign.
Speaking of scams, one scam I intend to avoid is the lawyer and agent scam.
Ill post the option contract here and we'll all go over it. I'm certainly not going to pay an agent for a deal I got on my own -- and paying a lawyer 5% for just reading the contract is even more ridiculous. And with both, the check comes in their name and they cut you your percentage on their bank draft.
And I know how lawyers say it's impossible to protect yourself without them -- but that's all old school urban legend. The internet has all the information you need, and forums like this will provide the rest. I'll consider paying a lawyer maybe 100 bucks to read the contract -- but 5%? That's insane!!!!
"Gary Lloyd, make sure you get an entertainment lawyer. Better safe than sorry..."
I don't think so -- although I would concur in 99% of the deals a lawyer is necessary.
First off, the people who'll finance this movie are English millionaires and billionaires. As you know, the English have the highest tax rate in the world. This means the English millionaire who doesn't double his investment within a year loses maybe a third of it to taxes. The lady who emailed me with the option offer is flying to London as soon as I sign the contract.
Here's the point: this is not your standard business model. We're talking $100 -$150 million in play here. Your garden-variety entertainment lawyer doesn't operate at this level. He operates at a level that stops at $20 -$50 million -- a level where people nickel and dime you. But how do they nickel and dime me when the budget is $100-$150? How can I get ripped off if the movie grosses $200 mil and I'm locked in at 2%?
I don't need a lawyer to get locked in at 2% of the gross. Sure, a lawyer wants you to think you do, but, sorry, I don't buy it. No lawyer is getting $50,000 of my dough for reading a contract. And what about greedy lawyers who wind up killing deals? Do you trust lawyers? I don't. I trust forums, though. I believe there's enough collective savvy here and in the other forums to tell me everything I need to know about my option contract. I'm going to post it and let you guys have it. Sorry, you'll be working for free, bro.
So what if you have to give them 5%? If this is actually scam free, then you just got your big break. Your life as a screenwriter just got a lot easier probably. The credits you'll get from something like this is huge.
Why risk the chance of screwing something over, because you didn't want to pay some money. Sometimes spending money is necessary.
Sure, that's the conventional wisdom on the issue, but I'm thinking out of the box.
Lawyers like to cloak what they do in mystery but at the end of the day, all they do is read contracts. But there are a gazillion contracts online -- contracts that protected writers just like me. Why can't I just insist on the same terms the guy who wrote "The Butler" got?
Look -- this lady called me. She represents one of the richest producers on the planet, and she called me. We were on the phone for 30 minutes, then she emailed me again to give me her cell. She said if I have any questions, feel free to call her over the weekend.
The contract will lay out the deal and I'll study and research it. There are books out there on this stuff. This is not rocket science.
More power to you man. I'm just saying that MAYBE this is a time to think conventional and not out of the box.
I hope everything works out great!
No lawyers ... or agents.
And I have no intention of writing another screenplay after this one. The odds are too daunting.
Why not? You just got past the most daunting of odds...getting your first script noticed. The credits from a production company like this could land you more sales for other scripts, or maybe even an agent.
Here's the deal: I write the best romantic comedy around -- the wittiest! -- bar none.
If this movie is produced it will definitely land an Oscar, possibly several.
The thing, though, is the people at the gate don't know from nothing. The Nichols judges didn't know -- I didn't make the first round. The agents didn't know -- not one would touch it. It took the people INSIDE the gate to recognise the kind of money they could make with my script. They knew.
They knew they could raise $100 mil with it.
I was outraged when my script didn't make the first round of the Nichols. I looked at some of the scripts that went on to the second round and couldn't believe it. One was a zombie movie by a 19-year-old who was obviously somebody's nephew. And if you think I'm slamming the Nichols now, wait until I get my check.
By the time this lady emailed me, she and the executives of her production company had already met and discussed my script several times. They are scheduled to go to London to pitch scripts and wanted mine at the top of the list. London is where the big money is. I'm talking concerns with billions of pounds that have to be moved quickly before the Queen takes her bite.
Want to write a script that will get financed in a heartbeat? Give it a British angle. In other words, "Follow the money."
I'm no expert in contracts, but I would HIGHLY suggest that you hire a competent entertainment lawyer to go through any contract before you sign it, especially if the numbers you are talking about are accurate.
I am sure you can find a good lawyer who charges by the hour, and doesn't take a percentage off anything.
Even if they charge 5%, I'd say it's worth it, since now they make sure that you get the best deal possible and don't get screwed.
I understand that you are on cloud nine at the moment, but it's important to still keep your feet on the ground and make sure everything checks out ok.
Getting your script optioned is a great thing, but it doesn't mean that it will get produced. Now you've got your foot in the door, so even if nothing comes out of this particular deal, you can leverage it to network with some people and maybe get an agent to shop the script around.
In any case, Iv'e got my fingers crossed for you, hopefully you can get your script produced!
Oh, boy, just when I thought I had it all figured out, somebody throws a monkey wrench in the works.
Ok, I'll bite -- who do you recommend?
My experiences with contracts and entertainment lawyers are very limited.
Maybe there are some other users here who could recommend a good lawyer for you?
Seems like my post was deleted..
Anyways, 200,000$ seems to me like a shitload of money - is that a common price, and how long is the script?
Just got off the phone with the producer. She told me I'd have the options contract late today or early tomorrow. She said her boss, wants six months instead of three -- that he needs that much time to secure financing. She asked me if the script is registered with WGA(?) I told her no, she said she'd pay the fee and register it for me. Her boss, is very well known and has several movies out there. I asked her how soon could she get me a check and she told me they've got some financing money coming in and she'd try to get me at least $5000 by Xmas.
She said the price they'd pay for the script would be a minimum of $100,000 and a max of $220,000. I asked if I should get a lawyer, she said definitely.
Finally, she said they'll be doing a "Page One" on the script subject to my approval.
I'll post the contract as soon as she emails me it.
Gary Lloyd, I want you to know that you've achieved what every single writer on planet Earth dreams of.
Please post the contract ASAP.
First, my latest report directly above should convince all the nay-sayers this is a done deal. Secondly, I will be completely transparent about this going forward. The only reason it's happening is because I posted my script at Simply Scripts -- which is a forum. I don't take that lightly.
That said, I want everyone to remember my script did not make the first round at the Nichols.
As to what I wrote maybe this will help: I found a 260 year-old story that had been kept secret. It begged to be told. This is to say, if you can find a story that begs to be told, you've made a good start. The Nichols people missed this. At the time, they were more interested in zombie movies, or so it seems.
Secondly, I told the story as well as it could be told. That was five years ago and even today, I can think of no way of improving it. By the way, my script was languishing for five years. I had forgotten about it, and gotten on with my life.
Anyway, waiting for the contract. I'll post it as soon as I get it.
What would be a few things you consider essential for enabling someone to advance at writing that applied specifically to you?
SEVERAL Oscars huh? And that is why you'll never be a screenwriter. wow.
Cockiness will get you no where. I'm having a hard time believing anything you've written. What's the name of your script called? When does it go to camera? How many Oscars do you think you'll actually win, 4 or 5? lol. Good luck, whatever you're doing.
Sorry, fellows, the deal fell through months ago. I should have reported back.
Let this be a lesson to never speak before the deal is signed.
While lawyers and such are rip off artists, nothing is worse than signing a contract expecting "this" and finding out you're actually getting "that".
You never have to sign with a lawyer. You could pay a lump sum and have them tell you what you're signing. If all you cared about is getting one lump sum of money, they'd tell you whether it's in there or not.
As someone once told me always sign for the gross not net. Because there is no net.


"Ringwood Waldorf School celebrates Festival of colours"
Bournemouth Daily Echo "Festival of Colour comes out in force at Ringwood Waldorf School"
Southern Daily Echo "New Forest school celebrates Holi - the festival of colour and love"
Holi is a festival of colour that marks the arrival of spring in India. Although originally it is a Hindu festival, it is perhaps one of the most important festivals in India, where colours and love are celebrated by everyone regardless of their religion, cast, age, beliefs. There are various legends and stories attached to the origin of this wonderfully vibrant festival, but as a child, having the freedom to throw colour on anyone and everyone without being told off, was enough for me to absolutely love this festival.
From my own childhood, there are many aspects of Indian life I remember fondly, and Holi is definitely one of the earliest and one of the best!
Having had such a great connection with this festival, what better way of celebrating it than with my class at Ringwood Waldorf School. We first celebrated Holi as a class festival in 2016. Once we were spotted by the other children at the school, I had plenty of requests to celebrate Holi as a school festival. So last year in 2017, Holi festival was celebrated and enjoyed by everyone at the school including parents, as well as the children and the staff.
There was a huge amount of disappointment amongst all the pupils when this year on 2nd of March ( the official day for Holi) our school had to be closed due to snow and icy conditions on the road. We had to postpone the celebration until the last day of term. I thought this would be the best day to celebrate Holi and also to mark the beginning of our spring/Easter break. We decided to celebrate whatever the weather!
Younger classes (ages 6 to 8) explored powdered colour by making Rangoli patterns on the floor of their classrooms. These powdered colours were lovingly handmade by my Class 7.
Holi #2 Rain did not stop Play!
The older classes, from Class 4 up (age 9 and up) played (throwing) Holi on the basketball court. My class and I asked all the children to donate £1 each to support this event and the money we raised is going to go to a children's charity called Manzil in Delhi, India.
I am so lucky to be working at Ringwood Waldorf School where the children, staff, parents and the whole community are so open, welcoming, and interested in cultures and traditions from all over the world.


Brands Material is a Total Labels Manufacturer; Brand Tags, Neck Tags, Paper Hang Tags, Price Tags, Arm Patches, Leather Patches etc., whether it be Embroidery, Woven, Printing or Screen Printing. We offer free artwork design with unlimited revise. The premium products are manufactured by Standard Industry, and we also give you a service-mind. We've gotten a reliable from many customer, they always repeat order because of our understanding and attention.


An ester of nicotinic acid that lowers cholesterol and triglycerides in total plasma and in the VLD- and LD-lipoprotein fractions. .
A vasodilator with general properties similar to NITROGLYCERIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020) .
Corrosive oxidant, explosive; additive to diesel and rocket fuels; causes skin and lung irritation; proposed war gas. A useful reagent for studying the modification of specific amino acids, particularly tyrosine residues in proteins. Has also been used for studying carbanion formation and for detecting the presence of double bonds in organic compounds. .


Never mind the fact that social media is becoming the primary means of finding leads online; e-mail marketing is still in the race.
You have a lot of things to think about before you choose an eye doctor. This is to ensure the best health for your eyes.
More often than not, one very essential matter to take note of when searching for these marital files is that Marriage Licenses in itself is not a proof of nuptial.


If you are following the latest business trends, you have probably read that running an online store is a real hit these days. The fast advance of technology, especially the Internet, has made these stores more popular than ever. People without experience can now start an online business venture. Doing business online is the simplest and most convenient way of doing business. Most experts in this field agree that using an eCommerce platform is a smart move. These platforms are offering pre-built shops that are easy to manage. Of course, there are many eCommerce platforms, but a few of them hold the largest shares of this market. Shopify and WooCommerce are probably the most used platforms today. So, which one is better?
To start with, there are over 850,000 online stores that use WooCommerce and around 270,000 that use Shopify. The first difference is that WooCommerce is completely free to use while Shopify costs some money depending on the package.
Another important difference between them is the concept. Namely, WooCommerce is an eCommerce plugin that lets users create online stores on their WordPress sites. On the other hand, Shopify is an all-in-one eCommerce site solution that lets people sell online by delivering every tool needed to start an online store.
There are more top 10.000 sites that use WooCommerce which is obviously a sign which option store owners prefer. It is interesting that WooCommerce is used in different industries from arts and entertainment to shopping, telecom and business and industry. Shopify is often used in the folklore, men's health, and eCommerce niche. The geographical usage is another thing that we should mention. It turns out that WooCommerce is more popular in every country in the world and the UK, USA, Spain, and Russia are not an exception.
Each of these eCommerce platforms has unique features, but they also have many features that they have in common. WooCommerce can be used only on WP-powered websites. In other words, you will have to pay for hosting before you can start building your store. Shopify users can build a store on the platform itself – the hosting is covered. However, Shopify users must be prepared to pay a monthly fee for the service. They have three different pricing plans that have different features.
Take all these things into account before you make your final decision.


Kinross took part in the 11th annual MINEX Mining and Exploration Forum, Russia's largest mining conference, to share best practices at our Kupol and Dvoinoye mines.
The forum brought over 500 leaders together from across the globe, including our own Claude Schimper, Regional Vice-President, Russia and Lou Naumovski, Vice-President and General Director, Moscow in October. Claude and Lou took part in panel discussions to talk about recent technological advancements at our world-class mines and Kinross' 20th anniversary of operating in Russia.
Claude spoke about Continuous Improvement projects at both sites that have helped reduce costs over the last few years and safety enhancements such as installing anti-collision sensors in underground mining trucks.
He also highlighted Kupol's hydroponics program which produces large amounts of lettuce and arugula – an impressive feat in the challenging sub-zero climate where food is costly to transport.
"Kinross was showcased as a mining leader in Russia," said Lou. The Company's economic benefit in the region was highlighted, including the 2,200 local jobs it has created and $211 million spent on local in-country procurement last year.
The anniversary-themed Kinross booth was a popular destination at the forum.


Animals' Voice is an Educational Trust and Wildlife Rescue based in Hampshire, England. Run by a Board of Trustees, our aim is to teach respect and educate children and adults alike about the cruelties and abuse animals suffer all over the world.
We believe that children, our adults of tomorrow, can learn by man's mistakes and through education bring about change and help protect the loss of species of animals, birds, insects, fauna, and flora, and make the world a better place for nature.
We have members in over forty different countries who receive our quarterly U.A.C.T.A. magazine, which keeps them informed of the progress we are making. Our literature is produced by a small team of staff at Animals' Voice, as is our magazine. Although a small publication it enables us to keep in touch with members world-wide.
As well as our campaigns against animal cruelty we also rescue sick and injured wildlife from around the New Forest Area. Over the years we have handled quite a variety, all of which when fully recovered from their injuries are released back out into the wild where they belong. Have a look at our gallery and see the animals past and current in our care!
We often give educational talks to school groups, Brownies, WI meetings, etc., and if invited we take along some of the animals we have rescued. To raise funds for our work we attend various shows, bazaars, and hold jumble sales and book sales, although our main support comes from membership of Animals' Voice and it is through our members generosity that we are able to help our animal friends.


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Glossary of Linguistics Terms
beginning with letter N
Browse the Linguistics Glossary
(context, mostly, US) a policy of favoring native-born inhabitants over immigrants
the policy of perpetuating the culture of the natives of a colonised country
(philosophy) the doctrine that some skills or abilities are innate and not learned
A word or phrase which has recently been coined; a new word or phrase.
(uncountable) The act or instance of coining, or uttering a new word.
The newly coined, meaningless words or phrases of someone with a Psychosis, usually Schizophrenia.
(neologism)
noun (plural nodes)
A knot, a knob; a protuberance; a swelling.
(Astronomy) The point where the orbit of a planet, as viewed from the sun, intersects the ecliptic. The ascending and descending nodes refer respetively to the points where the planet moves from S to N and N to S. The respective symbols are � and �.
The joint of a stem, or the part where a leaf or several leaves are inserted.
A hole in the gnomon of a dial, through which passes the ray of light which marks the hour of the day, the parallels of the sun's declination, his place in the ecliptic, etc.
(geometry) The point at which a curve crosses itself, being a double point of the curve. See Crunode, and Acnode.
The point at which the lines of a funicular machine meet from different angular directions; -- called also knot.
The knot, intrigue, or plot of a piece.
A hard concretion or incrustation which forms upon bones attacked with rheumatism, gout, or syphilis; sometimes also, a swelling in the neighborhood of a joint.
One of the fixed points of a sonorous string, when it vibrates by aliquot parts, and produces the harmonic tones; nodal line or point.
A swelling.
(graphtheory) A vertex of a graph.
(computing_theory) (context, computer networking) A vertex or a leaf in a graph of a network; a computer or other device attached to a network
nonce word
A word invented for the occasion.
Not standard.
(linguistics) Not conforming to the language used by the educated sections of a society.
Nunavut (Canadian territory)
Nuoro (Italian city in Sardegna)
A member of a Christian religious community of women who live by certain vows and usually wear a habit.


On www.antibodies-online.com are 156 Thyroid Hormone Receptor, alpha (THRA) Antibodies from 25 different suppliers available. Additionally we are shipping THRA Kits (40) and THRA Proteins (22) and many more products for this protein. A total of 226 THRA products are currently listed.
Thyroid receptors (TRalpha and TRbeta) are major components of the thyroid hormone pathway which is linked to neuronal development.
overview of the clinical features together with the underlying molecular mechanisms in patients with resistance to thyroid hormone due to heterozygous mutations in TRalpha (Review).
We found that the thyroid hormone receptor (TRalpha 3) has a differential expression profile. Thyroid hormone is critical for normal brain development. Our results showed that there is a possible link between IGF1/IGF1R and the TRalpha 3 and that over expression of IGF1R in RTT cells may be the cause of neurites improvement in neural RTT-derived neurons.
This large case series underlines the variation in the clinical phenotype of RTHalpha patients.
THRA predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB is expressed at lower levels and is upregulated during hADSC differentiation.
The expression of thyroid receptor alpha is linked to fertility status.
8 different THRA gene abnormalities have been described in 14 patients from 9 families with phenotypes including short stature, dysmorphic syndrome, psychoneuromotor disorders, constipation and bradycardia. Review.
The current study aimed to investigate whether TRs may be specifically expressed in BRCA1 associated cancer cases.
THRA mutations may be more common than expected. In patients with clinical symptoms of mild hypothyreosis without confirmation in endocrine studies, a molecular study of THRA defects is strongly recommended.
THRalpha rs939348 polymorphism was associated with L-T4 dose and central obesity among hypothyroid patients.
Thyroid hormone signalling may be important in a proportion of breast cancers and THRalpha2 expression may be a regulator of signalling in this pathway.
substantial reduction in the protein expression profile of THRs in malignant versus nonmalignant mammary epithelium suggesting a possible role in breast cancer development.
A new x-ray crystallographic structure of thyroid hormone receptor ligand-binding domains shows a second binding site for thyroid hormones.
Transactivation of reporter genes in response to T4 thyroid hormone was dependent on the thyroid hormone receptor subtypes in human cells.
Thyroid hormone receptor alpha mutation is associated with a severe and thyroxine-resistant skeletal dysplasia.
TRalpha1 and TRbeta1, preferentially partner with distinct panels of auxiliary proteins.
THRA gene polymorphisms are associated with obesity development. This is a novel observation linking the THRA locus to metabolic phenotypes.
Mutations affecting THRA are not a common cause of high BMD in healthy euthyroid post-menopausal women.
there is considerable evidence that TRalpha plays an important role in fat deposition in porcine adipose tissue.
regions of the Xenopus and mouse Klf9 genes 5-6 kb upstream of the transcription start sites that supported synergistic transactivation by TH plus GC.
Type 2 iodothyronine deiodinase activity is required for the death of thyroid hormone receptor (TRalpha)-transfected tail muscle cells induced by a low level of thyroid hormone.
Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 complexes by unliganded thyroid hormone receptors in transcriptional repression during vertebrate development.
Data show that thyroid hormone receptors directly mediate the developmental effects of thyroid hormone in individual organs by regulating target gene expression in these organs.
Binding of liganded thyroid hormnone receptor to the target promoter is reduced when arginine methyltransferase 1 was overexpressed, accompanied by a slight reduction in histone methylation.
PRMT1 functions transiently as a coactivator in thyroid hormone (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis.
T(3) acts to induce cell proliferation in the tadpole brain predominantly, if not exclusively, via TRalpha.
Data provide evidence that zebrafish represents a valid model to study in vivo the thyroid hormone (TH) action, and the molecular mechanisms underlying the two syndromes of TH resistance, RTHa and RTHb.
zebrafish uses both alternative splicing and differential expression of TRalpha genes to diversify the cellular response to thyroid hormones.
Knockdown of the main TR in macrophages, TRalpha, impaired polarization into proinflammatory macrophages and amplified polarization into immunomodulatory macrophages.
Data suggest that gestational/maternal endocrine disruptor DEHP [di-(2-ethylhexyl) phthalate] exposure dose-dependently causes fetal IUGR (intrauterine growth restriction); mRNA levels of placental Thra1 and Thrb1 are reduced and nuclear translocation of placental Thra1 and Thrb1 is suppressed in DEHP-exposed mice.
neonatal hypothyroidism alters localization and expression of THRalpha1.
Study demonstrated an anxiety-related phenotype in mice expressing a neuron-specific TRalpha mutation. This provides evidence that altered thyroid hormone signaling in the brain impacts adult behavior.
the Gata-1 gene was a T3-directly regulated gene and that TRa1PV could impair erythropoiesis via repression of the Gata-1 gene and its regulated genes. These results provide new insights into how TRa1 mutants acted to cause erythroid abnormalities in patients with mutations of the THRA gene.
Using domain exchanges and individual amino acid switches between THRA1 and THRB2, three amino acidswere identified in helix 10 of the THRB2 ligand-binding domain that are required for negative regulation and are absent in THRA1.
Hippocampal transcriptome profile of persistent memory rescue in a mouse model of Thra1 mutation-mediated resistance to thyroid hormone has been reported.
Data (including data from studies in knockout mice) suggest mitochondrial T3Ralpha in brown adipose tissue is key to regulation of energy metabolism; knockout mice exhibit hypermetabolism/hyperphagia, but not cold intolerance/defective thermogenesis.
Data (including data from studies in mutant strains of mice) suggest Thra1 (but not Thrb) plays role in myogenesis, cell proliferation, and resistance to T3 (triiodothyronine) in skeletal myoblasts; Thra1 promotes muscle regeneration after injury.
In thyroid receptor-deficient mice, hair follicle stem cells present a clear defect in their mobilization (exit of their quiescent state and migration out of the niche), associated with increased activation of Smad signaling.
the presence of a mutant TRalphaAMI allele in both Leydig and Sertoli cells does not accentuate the phenotype in comparison with its presence in Sertoli cells only.
The thyroid hormone nuclear receptor TRalpha1 controls the Notch signaling pathway and cell fate in murine intestine.
Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells.
TRalpha is essential for the control of vascular tone, particularly thyroid hormone-mediated relaxation.
TRalpha/T3 directly acts on the P450c17 promoter, which contains putative thyroid response elements, and indirectly acts on the promoter of steroidogenic enzyme genes by modulating Nur77 transactivation on these promoters.
Histone deactylases confer in vivo aberrant actions of TRalpha1 mutants in a mouse model of hypothyroidism.
Selective expression of TRalpha1 in endothelial cells protects the heart against injury after an ischemic insult.
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.


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Home About News and media News updates Outdoor excursions life-changing for youth
Outdoor excursions life-changing for youth
Outdoor adventures inspire youth
An increasing number of young people in the Waikato region are exploring their backyards thanks to a social enterprise adventure group called Got To Get Out.
Got To Get Out usually arranges adventures and outdoor excursions for adults with the aim of getting Kiwis active and outdoors to improve their mental and physical health. Now, thanks to Tū Manawa Active Aotearoa funding received through Sport Waikato, it has expanded its offering and designed a programme specifically for rangatahi and tamariki.
So far about 400 youth from schools and youth organisations have experienced the Got To Get Out programme which takes them on a day-long excursions to regional parks, mountain bike trails and forests around the region.
"It's a series of outdoor adventures to inspire youth in the Waikato to explore their backyard, to get fit, to get into nature and build confidence through organised hikes, bike rides and even paddle boarding," explains Got To Get Out founder and lead adventure guide Robert Bruce.
Aimed at five to 18-year-olds who face financial barriers to participating and who aren't involved in regular physical activity, Robert says their experiences have been life-changing.
And feedback from participants, youth leaders and school staff alike has been nothing but positive.
"Eighty percent of attendees are of Māori descent, and they appreciate connecting with the whenua (land) and learning principles of kaitiakitanga (guardianship) in order to leave the trip with a greater respect and appreciation of conservation and caring for the land."
Robert guiding mountain biking (Photo credit Chris Chase Photography)
Robert says 80 percent of attendees feel more confident to get outdoors after their activity, with 88 percent wanting to do it again.
As a direct result of the activity, Robert says 90 percent said their mental health has improved, and 80 percent are more likely to get outdoors in future.
Robert describes a group of rangatahi from Huntly who visited the tallest kauri tree in the region, in the Hakarimata forest.
"On arrival to the huge majestic tree, almost involuntarily, the boys went up to the tree and pressed their noses to its mighty trunk – giving the tree a hongi and sharing mauri (life force) with it. The whole group, including guides and mentors, were deeply moved and silent as the group engaged with nature."
Sport Waikato chief executive Matthew Cooper adds, "It's absolutely awesome to see a programme like Got to Get Out helping our tamariki and rangatahi, often who don't have these opportunities available to them, to get out and be active in our natural environments often for the first time.
"Not only are they finding a love for the outdoors, but they are learning how to work together through team building and real life lessons that being active in the outdoors teaches them."
Tamariki engaging with nature (Photo credit Chris Chase Photography)