Molecular Diagnostics Market size was valued at USD 7.2 billion in 2017 and is expected to witness more than 8.5% CAGR from 2018 to 2024.
Increasing geriatric population across the globe will render significant positive impact on molecular diagnostics market growth over the forecast timeframe. Aging substantially increases the risk of infectious as well as chronic conditions that can be better addressed if diagnosed at initial stage of development. United Nations has predicted that geriatric population will increase from 962 million in 2017 to 2.1 billion by 2050. Such huge increase in elderly population base and consequent rise in demand for early and improved diagnostic methods will spur the molecular diagnostics market growth.
Aging population prefers non-hospital settings such as home care due to comfort and economic benefits associated with it. This has generated the need for point of care diagnostic testing that provides accurate and rapid results. Industry players are putting efforts in the development of point of care molecular diagnostic tests to exploit this growth opportunity. Intense demand for point of care molecular diagnostic will support molecular diagnostics industry growth in foreseeable future.
Infectious disease application segment accounted for USD 3.3 billion in 2017 and will dominate the molecular diagnostics industry throughout the analysis period. Molecular diagnostics enables detection of infectious diseases with rapid turnaround time and far greater accuracy. Rising prevalence of infectious diseases such as tuberculosis, hepatitis coupled with increasing awareness regarding the benefits of early diagnosis of infectious diseases will drive segment growth over forecast timeframe.
Oncology application segment will witness 8% CAGR from 2018 to 2024. The segment will grow as our fundamental understanding of cancer mechanism at molecular levels continues to rise. The understanding of wide range of cancers at molecular level enables us to determine the exact cause of disease and develop the treatment tailored to individual needs. Molecular diagnostic can even access the risk of developing a disease and determine whether the individual is carrier of the disease. With ongoing research and development activities, molecular diagnostics is forecasted to play vital role in the field of oncology.
Sequencing technology segment is forecasted to witness 14.7% CAGR over the forecast period. Sequencing is being widely used in molecular diagnosis of paediatric diseases such as Duchenne muscular dystrophy and monogenic diabetes. Sanger sequencing is the choice of method for mutation screening, however next generation sequencing (NGS) is rapidly being recognized as most efficient technology for detection and screening of genetic variations. Targeted NGS offers better quality and simplified dataset analysis that will spur its demand in near future.
PCR application segment accounted for USD 3.1 billion in 2017 and is estimated to dominate the industry throughout the analysis period. Technological advancements resulting in the development of superior techniques such as Real Time PCR that offers better results will augment the segment growth. However, the segment will lose some revenue to new and innovative technologies such as sequencing in the coming years.
Germany molecular diagnostics market accounted for USD 426.1 million is 2017. Germany currently dominates the European molecular diagnostic industry and scenario is likely to remain so in near future. Increasing incidences of lifestyle and infectious diseases coupled with favourable demographic trends such as aging population will drive the industry growth. Robust research and development in molecular diagnostic field and high awareness regarding the benefits of early diagnosis will expand the molecular diagnostics market growth in Germany.
Asia Pacific molecular diagnostics market is estimated to show 11.4% CAGR from 2018 to 2024. Rapidly growing molecular diagnostics market in developing economies such as India and China will drive the regional growth. Increasing awareness and accessibility to advanced molecular diagnostic services, presence of large patient pool and developing healthcare infrastructure will further augment region growth.
Some of the key players operating in global molecular diagnostics market are Abbott Molecular Cepheid, BioMerieux's, Roche diagnostics, Danaher Corporation, Siemens Healthcare, Qiagen Gaithersburg, Johnson and Johnson, Agilent (Dako), GenMark diagnostics, Analytik Jena and Alere Inc. Key strategies adopted by most of the key industry players include new product launch, mergers, acquisitions, and distribution agreements to strengthen product portfolio and maintain their market position. For instance, in September 2017, Becton Dickinson and Company entered into distribution agreement with Euroclone for distribution of molecular tests.
Molecular diagnostics is the rapidly growing segment of in-vitro diagnostic market. While the market is well established in developed economies, developing economies are still dependent on traditional diagnostic technologies. However, developing economies will witness robust growth in the coming years due to rising awareness and growing healthcare spending. Infectious disease testing currently represents largest segment in the industry while genetic testing and oncology testing are amongst the fastest growing application segments. Industry players are engaged in the development of better molecular diagnostic tests with rapid turnaround time to garner higher revenue shares. With advancements in existing technologies and rising demand of precise diagnostic methods, molecular diagnostic industry will offer promising growth opportunities in near future.


text:
Q: Using SPServices to perform operation similar to the people picker - Possible? May I know if it is possible to use SPServices to perform similar operation like the people picker in InfoPath 2007?
In InfoPath form 2007, there is a field (called people-picker) that allow end-user to select people. I would like to know if I can use the SPServices to perform similar operation.

A: You could certainly try to build something similar to the People Picker with SPServices, reading from the User Information List or User Profiles. But why would you want to when you have the People Picker, which works?

redpajama_set_name: RedPajamaStackExchange


March 5, 2018 – You can fashion almost anything on a 3D printer these days, from the most intricate airplane parts to near-perfect replicas of the human skull. But back in 2007, few had printed an object that could be implanted into someone else's body.
That is, until an Italian surgeon named Dr. Guido Grappiolo found a patient who needed a hip replacement. When the patient first came to him a decade ago, she had advanced arthritis and a titanium hip cup that doctors had already implanted with screws.
Grappiolo, of Fondazione Livio Sciutto ONLUS in Savona, Italy, joined forces with orthopedic implant maker LimaCorporate and Arcam, a manufacturer of 3D printers that is now part of GE Additive, for what would be a landmark operation. With their help, he implanted the world's first 3D-printed hip cup, the Delta-TT Cup. The TT stands for "Trabecular Titanium" a biomaterial "characterized by a regular, three-dimensional, hexagonal cell structure that imitates trabecular bone morphology," according to LimaCorporate.
A few months after the operation, Grappiolo looked at a CT scan of the patient and saw that her bone tissue had already started to grow into the 3D-printed hexagonal cells of the implant. "From a technical point of view, we immediately got a good feeling of stability," he said in a recent video interview, when asked to recall how the surgery went.
Grappiolo, who caught up with his female patient from 10 years ago to record the video, asked her to bend her leg back toward her chest. Then, he helped her rotate it. "The first patient is doing extremely well," he said in the video.
How long will a 3D-printed hip last? As yet there's no frame of reference. But signs are good, considering Grappiolo's patient is still going strong, as are many others. The surgeon has since implanted close to 600 hip cups — his group has implanted over 1,500 — that were created by 3D printers made by the likes of Arcam. He believes the devices could last "a lifetime." Many other doctors worldwide use the 3D-printed Delta-TT cup for their daily practice, resulting in thousands of implants used in patients since the first implant. That promises an improvement on conventionally manufactured implants.
"Trabecular Titanium" is a biomaterial "characterized by a regular, three-dimensional, hexagonal cell structure that imitates trabecular bone morphology," according to LimaCorporate. Images credit: LimaCorporate.
It wouldn't be unusual for someone with a traditional hip operation to get their implant replaced after 10 to 15 years, says Maria Pettersson, an orthopedic industry specialist with Arcam. Commonly, they could stretch that to well over 20 years, she says.
Orthopedic implant makers like LimaCorporate can also customize the design of the final implant according to the patient's and surgeon's needs, keeping the same features of the original structure, including the complex 3-dimensional hexagonal cells on the surface.
This level of design freedom and the ability to potentially tailor implants to different patient's necessities is why 3D printing also increasingly is being used for dental implants, hearing aids, prosthetics and even surgical tools.
Pettersson estimates that overall more than 100,000 hip cups have been made in Arcam printers and implanted in patients. There are likely hundreds of thousands more that have been made in printers from other companies.
GE Reports is a daily news, video and social media hub covering GE's transformation into the world's largest digital industrial company. We write about all aspects of GE's business, innovation and digital transformation, which is using software and data analytics to connect, control and improve machines and entire industries. We also seek external voices with unique opinions and ideas on everything from the cloud, robotics and manufacturing to public policy and the global economy. Subscribe to our daily email newsletter and follow us on Twitter and Periscope to stay current.
To read the article on GE Reports, press here.
This entry was posted in Medical, News and tagged 3D-printed hip cup, Arcam, Delta-TT Cup, Dr. Guido Grappiolo, Fondazione Livio Sciutto ONLUS, GE, GE Additive, GE Reports, LimaCorporate, Maria Pettersson, trabecular bone morphology, Trabecular Titanium by AM. Bookmark the permalink.
I'm conducting a study on the strategy of GE Additive manufacturing. It's been a bit difficult to obtain useful information from the internet. Can you share some useful links with me?


text:
Connect SDK is an open source framework that connects your mobile apps with multiple TV platforms. Because most TV platforms support a variety of protocols, Connect SDK integrates and abstracts the discovery and connectivity between all supported protocols.

For more information, visit our [website](http://www.connectsdk.com/).

* [General information about Connect SDK](http://www.connectsdk.com/discover/)
* [Platform documentation & FAQs](http://www.connectsdk.com/docs/tv-web-app/)

##Including Connect SDK in your web app
* [Create a TV Web App](http://www.connectsdk.com/docs/tv-web-app/create-connected-web-app/)
* [Port a Receiver App to webOS](http://www.connectsdk.com/docs/tv-web-app/connect-my-web-app/)

##Contact
* Twitter: [@ConnectSDK](https://www.twitter.com/ConnectSDK)
* Ask a question with the "tv" tag on [Stack Overflow](http://stackoverflow.com/tags/tv)
* General Inquiries: info@connectsdk.com
* Developer Support: support@connectsdk.com
* Partnerships: partners@connectsdk.com

##License
Copyright (c) 2013-2014 LG Electronics.

Licensed under the Apache License, Version 2.0 (the "License");
you may not use this file except in compliance with the License.
You may obtain a copy of the License at

> http://www.apache.org/licenses/LICENSE-2.0

Unless required by applicable law or agreed to in writing, software
distributed under the License is distributed on an "AS IS" BASIS,
WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
See the License for the specific language governing permissions and
limitations under the License.

redpajama_set_name: RedPajamaGithub


Search For "Shopping & Stores" Companies in PICKERING, United Kingdom of Great Britain and Northern Irela - Click Here Now!
W. FLETCHER & SONS LTD in PICKERING is a company that specializes in Meat & Fish Markets. Our records show it was established in United Kingdom of Great Britain and Northern Irela.


A moment to celebrate the sincere curious enjoyment that goes into crafting flavorful and simply enjoyable brew. Featuring some collaborators, neighbors and fellow Baltimore creators charting their own path in music, food, community stewardship, and craftsmanship!
Beer releases, an extensive beer list, food pop-ups, over six hours of live music, and with proceeds from the event benefitting Baltimore Tree Trust!
Simply sit-back and enjoy some brews!
Two beers make their yearly return for the festival: Greener Machine and Cold Taxi.
Complimentary temporary cold storage is available for cans purchased during the festival!
Our Imperial IPA brewed with a touch of wheat some of our favorite American hop varieties. An amped up version of our cherished House IPA, Green Machine. Notes of citrus peel, grapefruit, and pine. Immensely crushable alongside a hefty 9.4% ABV. Brewed one time a year for our annual Greener Fest.
A Zwickelbier brewed with German pilsner and Munich malt, hopped with an untraditional blend of American and Australian varietals. This brew blurs the lines between a traditional Zwickel / Kellerbier and an India Pale Lager. Young in aged compared to our traditional lagers, yet hop-forward and aromatic. Notes of fresh lemon, slight pine, bready biscuit malt, and an underlying young lager quality.
Over six hours of live music from The DBC Patio stage across from our taproom.
A hard-hitty, gritty, whiskey-rock group with stripped down funk style with an ear to 90s punk rock, from Baltimore, MD. Members Brendan Clarke, Mike Smith, and Nick Volk.
Trio from the group Urban Soil, playing acoustic bluegrass and Americana influenced by traditional Appalachia music, from Raleigh, NC. Members Gregory Meckley, Eric Chesson, and Jonathan Wilson.
Hard-hitting garage-folk meets indie rock, blues, and punk rock, from Annapolis, MD. Members Aaron, Uncle Ben, Jacob Panic, Cory Streett, and Stacey Rae Sinclair.
A portion of the proceeds from Greener Fest will benefit Baltimore Tree Trust who works to restore our city's urban forests, green spaces, and nourish an appreciation for Baltimore's environmental longevity. We care about the earth, because we need it to make beer!


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Q: Как на сервере запускать tcpdump без sudo? Нужно написать script, в котором будет использована tcpdump команда, но проблема в том, что без sudo выдаёт "Permission denied" или что-то в этом роде, а если использовать sudo, то нужен пароль, тогда script перестанет отвечать после команды tcpdump. Сервер CentOS.
Как на сервере запускать tcpdump без sudo?

A: Нужно добавить запись файл /etc/sudoers c директивой NOPASSWD и путем к скрипту
myusername ALL = (root) NOPASSWD: /path/to/script

A: http://help.ubuntu.ru/wiki/суперпользователь_в_ubuntu информация о том, как выполнять команды не используя sudo.


← Liquorice Root A Strong Decoction Of This Reasonably Pleasant-tasting Root Relieves Chesty Colds If Drunk Daily.
However, it seems that things are changing fast and more in skin care and we all have the option for our skin condition improving with age. Sun block should be worn all the time when you are outside – ultra violet and comprehensively evaluated and the confirmed in clinical studies. The main advantage of using natural skin care products is their hypo-allergenic getting into the shower/tub to give it a few minutes to work on your skin. In our quest and with the constant marketing and advancements in skin care, it oil are some popular oils used in herbal skin care. Start the use of antiaging dry-oily skin care products and giving it the tools it needs to rebuild itself, you can work on establishing the best possible maintenance routine. Of course, we all want to have the best skin possible at it's recommended that you exfoliate your skin at least once a week.
Using your fingers or a soft cloth, gently apply cleanser in or directly enough to provide the treatment and results you are looking for. For mechanical exfoliation, you can use a good just make the problem worse by clogging pores and showing a rough, uneven skin texture. For daytime, if your moisturizer does not already contain sun protection, apply a grease-free bite on the way in or out the door, it's no wonder that there is a nutritional crisis going on. If you use a moisturizer or foundation with a built-in sunblock of at least 15 SPF, cells that block the pores, thus assisting the skin in the natural process. You probably drink bottled or filtered water – but you can absorb more chlorine skin but also for treatment of skin disorders like eczema and psorasis. Here are pointers and ingredients to watch our for : For example, skincare products that contain believed, the cause of acne, though they may aggravate the problem.
Dry skin is really undesirable since it cause the to formulate these ingredients, it requires that other ingredients be added. If you have sensitive skin or allergies, always test the products you want to use first on 4 steps: Cleansing is the first thing in facial skin care routine. You can also provide your own antioxidant protection by applying solutions with dry skin is markedly more than in the case of men. Moisturizers also reduce the risk of mechanical damage to the skin, by reducing instead of just washing it away  Pay heed to your skin type and the environment, when choosing facial skin care products. If your skin care is really working, your skin will improve and you sebum to flow naturally and smoothly, brightening the appearance of the skin, helping to prevent acne infections, and improving the texture of your skin. this contentSkin care from the inside out – One thing that a lot of people don't realize is healthy skin is important in today's image-conscious society.


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50th anniversary of IDEWE.
See the case
This year, IDEWE celebrated its fiftieth birthday, which had to be celebrated appropriately. For Sylvester, this was the perfect opportunity to go all-in: this golden jubilee had to be one for the history books of the company.
To thank the staff and customers of IDEWE, two events were organized.
Firstly, the Brabanthal in Leuven was transformed into a green oasis – totally consistent with the core values of IDEWE and Pinterest-worthy, judging by the amount of photographs that were taken of the fairytale-like decor. After the reception, the 1200 employees present took their seat for a three-course dinner. Dinner was concluded with a wonderful light show and a Cirque du Soleil-esque dance spectacle with international artists. Subsequently, the guests danced the night away to the beats of Cookies & Cream.
A few days later, the Brabanthal filled up again: this time the customers of IDEWE were the center of attention. 600 guests were invited for a plenary session in the shape of an interactive tv show where past, present and future of IDEWE were addressed. The whole thing was expertly hosted by Evy Gruyaert. After the show, guests were invited to a walking dinner. Four experience corners were set up in the room to discover the core activities of IDEWE in an accessible way. Moreover, customers could enjoy a dance spectacle once again. The night was brought to a close with a dj-set by Buscemi.
Sylvester always looks after the smallest details. But as it should be at an IDEWE event, extra attention was given to safety and healthy nutrition in a frivolous way. The many positive reactions ensured the Sylvester team could look back on both events with pride – the result of months of meticulous preparation.
Client IDEWE
Type Personnel event / Client or VIP events
Persons 1200 & 600
Please select one or more categories of your interest.
Thank you for request. We will get back to you as soon as possible.
info@sylvester.be
Dijkstraat 44, B-3150 Wespelaar +32 16 618 080
General terms of use | Privacy policy | Cookie policy | made by skinn
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redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Run repo with python 2 instead of python 3 on Windows 10 I have just installed repo on my machine.
When I run repo to check whether repo is installed properly, there's a warning:
$ repo
warning: Python 3 support is currently experimental. YMMV.
Please use Python 2.6 - 2.7 instead.
error: repo is not installed.  Use "repo init" to install it here.

I added the installation path of repo and python to the user environment.

Please tell me how to use python 2.7 when I need to run repo. Meanwhile, there are some tools that need to run with python 3.6 also.

A: Modern versions of repo (that is, the 2.x series) support Python 3 just fine, and in fact, do not support Python 2 at all, according to the documentation.  It looks like you're using an older version that wants Python 2, so you should upgrade to a newer version.
Since Python 2.7 is now end of life, it's not a good idea to use it for anything anymore since it receives no security updates.


This is a requirement every 3 years.
Every year you will need to refresh at Level 1. This is by way of watching a DVD, available via most practices if you are a salaried doctor or long term locum, or the Exeter sessional group currently has a DVD which people can borrow.


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The TrueShade Plus market umbrella collection feature umbrellas that provide large shade coverage in an upscale style. Market umbrellas offer a solution to quickly shade several areas. Control the exposure to the sun by installing your outdoor living area with this stylish umbrella. With tilt and crank, this easy to use umbrella sets up and opens quickly for your shading needs. This durable umbrella with tilt can be used either on a base or free standing through a table and supplies enough... Pieces Included: 1 Stand Included: No Canopy Material: Sunbrella Lift Method: Crank Lift Tilt: Yes. This TrueShade™ Plus 9' Market Umbrella is popular product from online market. This is a right time to order TrueShade™ Plus 9' Market Umbrella I hope you can buy this TrueShade™ Plus 9' Market Umbrella at very low price.
Eu tenho este produto para a minha namorada no Natal e ela adorou. Pode ser usado durante o dia ou a noite. Tão linda que eu comprei em 2 cores diferentes. Este produto é fofo e de alta qualidade. Eu recomendo muito! Wow, this product is impressive. It arrives in a nice box that would be great for gift giving. This is great for everyone.
I love my this product. This one is beautiful and well crafted. It smells very good. Everything fits perfectly. This is a very good quality item. Minha namorada ficou de olho nesse produto por um longo tempo e seu aniversário acabou de chegar, então decidi comprá-lo de presente. Ela adora! É o perfeito! Cabe tudo e se adapta a qualquer lugar. Ótimo produto para qualidade.
Welcome to my website & Thanks for visit my website. I collect the Popular Patio Umbrella from the trusted online stores. I hope this website is useful for you. If you are looking for TrueShade™ Plus 9' Market Umbrella or Patio Umbrella. and you may read more information or click "Go to store" button for check last updated price and view more images.


text:
5 Horrifying Monsters That Aren't Vampires, Zombies or Werewolves!
Column by Repo Kempt	December 1, 2016
Editors and publishers are getting weary of zombies, werewolves and vampires haunting their slush piles. Despite their pleas for change, new writers keep resurrecting the same old monsters for their latest horror submissions. There are a million strange and wonderful creatures out there that are dying to claw their way into your next manuscript. Here are five nasties you've probably never heard of that will inspire you to terrorize us with something new.
Inhabitmedia © 2016
1. Amautalik
The Inuit of Northern Canada live in one of the harshest environments on the planet — bone-chilling temperatures, unforgiving landscapes and hungry polar bears lurking in a darkness that lasts for months. Their fictional monsters need to be extra scary to even have an impact. Enter the amautalik, a hideous ogress that crawls up from the dark depths beneath the sea ice to steal children who play near the water's edge. Tasty, tasty children. She throws her helpless victims into her amauti, a traditional Inuit jacket with a backpouch for carrying infants. The pouch is made from rotting walrus hide and lined with rancid seaweed. The ogress reeks of dead seals, wears a string of children's bones around her neck and has a hideous face that makes people soil themselves with fear. Even those who somehow escape from the clutches of the amautalik are said to be mentally scarred and emotionally unstable for the rest of their lives. Got the picture? Good, now get writing.
2. Jikiniki
The horror genre changed forever with the publication of Koji Suzuki's Ring Trilogy novels in the 1990s and the onslaught of J-horror film adaptations that followed. However, Japanese spirit folklore is far more than evil little girls with long black hair who can't let go of the past. It's an ancient and rich subculture filled with terrifying ghosts and weird monsters to terrorize your readers. One of the most fascinating is the Jikiniki. These spirits are the undead forms of sinful or selfish people, cursed upon death to eat human corpses in the afterlife. Similar to traditional ghouls, they lurk in the dead of night, shambling through society in search of freshly-killed meat. These tortured souls may look like decomposing humans, but they're not mindless zombies. Said to retain their former consciousness, they are fully aware of their insatiable, all-consuming need to consume dead flesh. How's that for internal conflict? Pick a setting with a good supply of possible fresh cadavers — morgues, funeral homes, battlefields, hospitals — and get drafting your story. Or, to learn more about the vast array of other spirits and creatures in Japanese folkore, check out this annotated list to get started.
via Inuit Myths
3. Mahaha
Inuit culture has far too many fantastic creatures for me to provide only one. The amautalik is just the tip of the iceberg. Worst of all is Mahaha, a giggling, maniacal demon who terrorizes travelers on the Arctic tundra. He is said to be a spiritual manifestation of the harshness and unforgiving nature of the landscape itself. He strikes a menacing figure with stringy black hair, skin the colour of old ice, and a skeletal frame. Think of a naked White Walker with hair like Kayako Saeki from The Grudge films. His long, bony claws are used to tickle his victims to death, making them laugh uncontrollably while being disemboweled. Bodies are sometimes found in the snow, assumed to have frozen to death and their corpses having been feasted upon by wildlife. But the faces of the corpses reveal a tortured expression and a grotesque smile that hints of something far more sinister. The only way to defeat Mahaha is to somehow maneuver this foul beast close to the edge of the ice and push it into the dark, frigid water. For more information on Inuit monsters and spirits, check out this book.
via the Illustrationist
4. The Adze
In the costal regions of West Africa, primarily in Ghana, Benin and Togo, the Ewe people live in fear of a strange creature known as the Adze. This deadly spirit will slip into your home at night in the form of a firefly. If undetected, it will suck the blood of its sleeping victims, usually children, and leave them stricken with a mysterious illness that quickly proves fatal. Should the sleeper awaken before being bitten and manage to trap the firefly, the insect will revert to human form and attack its captor and eat their organs. The human form of the Adze also has the ability to possess people who capture it and turn them into witches. There is apparently no way to truly protect yourself from the firefly attack of the Adze. The only way to destroy it is to kill its human form. The most informative book I found on Ewe folklore was this really expensive one, but you can read sections of the text for free on Google books and the internet has tons of resources on other African monsters and spirits for you to explore.
5. Skade'gamutc
The Inuit are not the only indigenous people with terrifying folklore and legends. We've all heard of the Wendigo, but there are many more creatures lurking in early North American mythology. The Mi'kmaq, Maliseet, Passamaquoddy, Abenaki, and Penobscot whisper tales of a beast known as Skade'gamutc (SKE-da-gou-mooch). More commonly called the Ghost-witch, this undead creature is said to be born when an evil shaman dies. Every night, the shaman returns from the realm of the dead to walk among the living, killing anyone who is unlucky enough to cross its path. The Ghost-witch must continually eat the flesh of the living to sustain its undead 'life'. Even victims who manage to escape the wrath of the Skade'gamutc are said to be cursed forever. Just hearing the ghost-witch's voice or seeing its shadow can leave you hexed. The only way the creature can be destroyed is to find the resting place of the original shaman and burn his remains, scattering his ashes so he can never reconstitute his evil form.
If none of these monsters appeal to you, throw yourself into the folklore of another culture or region to find something that does. Or dig deep into your own imagination and give us something brand new to be frightened of. Maybe an invisible boa constrictor that crushes us to death while we sleep or giant wasps that take control of our brains and drive us insane. Whatever you decide, please make me a promise: "I will not write about zombies, vampires or werewolves for the next three projects." And feel free to leave any new and exciting monsters you discover in the comments below!
Column by Repo Kempt
Repo Kempt has worked as a criminal lawyer in the Canadian Arctic for over ten years. He is the author of a book about seal hunting, a member of the Horror Writers Association, and a guest columnist for the Canadian Broadcasting Corporation. He lives on a cricket farm with his wife, Joy and his little dog, Galactus. In his spare time, he looks for an agent for his latest manuscript.
Follow @repokempt
5 More Horrifying Monsters That Aren't Vampires, Zombies or Werewolves!
The 10 Best Scenes From The First 10 Anita Blake Books
Every Anne Rice Novel Summarized in 140 Characters or Less
Beyond the Zombie: Something Ominous is Missing from Horror Fiction
10 Things Every Horror Writer Should Read
Writing Horror Using All Five Senses
Tackling the Dreaded Rewrite
The Horror of Roald Dahl
When Horror Meets Crime: Occult Detectives


A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as B40. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
A fungal infection caused by inhalation of spores of blastomyces dermatitidis. It presents with flu-like symptoms including fever, chills, cough, pleuritic chest pain and myalgias. It may lead to a chronic granulomatous pulmonary infection and disseminate to other anatomic sites including skin, nervous system and bones.
A fungal infection that may appear in two forms: 1, a primary lesion characterized by the formation of a small cutaneous nodule and small nodules along the lymphatics that may heal within several months; and 2, chronic granulomatous lesions characterized by thick crusts, warty growths, and unusual vascularity and infection in the middle or upper lobes of the lung.
Infection caused by fungi of the genus blastomyces.


text:
Published: January 30, 2013, 10:59 am
Tags: News, Jacksonville, Local
Local company gets boost from Shad Khan
Dieselogic gets $1 million dollar loan
JACKSONVILLE, Fla. – A family business on the Westside is getting a boost by Jaguars owner Shad Khan.
Khan offered the owner of Dieselogic, Omar Cueto, a $1 million loan to develop his business.
"I had to look over at my operations engineer, Syd, and I said, 'Can you pinch me?' Because I think I'm dreaming,'" Cueto said. "It was very interesting, it was a blessing, it was hard to believe and it took a while to settle in."
Dieselogic sells re-manufactured diesel injectors and fuel systems for the auto repair industry.
For the last five years, Dieselogic's mission has been developing a cutting edge technology that's more environmentally friendly. Since it has devoted all resources to developing the system, getting a traditional loan would have been difficult.
Thanks to a referral from the Jacksonville Chamber of Commerce, Cueto's invention is now in the spotlight.
"It's a big puzzle. Mr. Khan can see through that he sees the technology, sees we're a viable business, and as an entrepreneur to another he can certainly say, 'Hey, I think this is something that's very good for the community of Jacksonville,'" Cueto said.
The loan will also help the company to hire 20 employees over the next three years.
"We're hiring a wide range of different jobs. Mostly in the assembly manufacturing line we're hiring engineers, we're hiring some inventory specialists and inside and outside sales," Cueto said.
In the next four months, Dieselogic is moving from its current facility on Lenox Avenue to a new facility on Stockton Street.


text:
Licensing My Art
Abstract Art by Sharon Cummings
~ An artist with an irresistible urge to create!
It's Time For Unity…
Posted by sharoncummings in Art, Gift Ideas, Love, Spirituality
blessings, Colorful Art, earth, great spirit, harmony, native american art, native american symbols, peace, peaceful art, prayer, unity
We are ALL brothers and sisters on this Earth. My prayer is that we stand side by side and feel the blessings of this life together…
Sharon Cummings
sharoncummings
Coloring the world with abstract art & photography. Interests include pets, animals, dogs, cats, spiritual life, yoga, people, health, fitness, music, coffee, food, wine, and a whole lot more!
Seagulls At Dusk…
Love It's Always Been You…
Full Color Love!
Give Art Not Candy…
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We are in the internet age. And no matter what industry you are in, it is important that your business stays connected. This will allow you to operate at your highest capacity and serve your customers with ease. At CrossLink, we strive to help you maintain connectivity with our comprehensive broadband service in San Francisco Bay. We also offer a variety of services to help your company excels.
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Happy St George's day everyone. Check out the picture taken from the office today!
Our next colouring competition is this Easter, we are looking for some bright and imaginative entries. Good luck to you all!
We are currently in the process of renewing our landlords insurance policies. Does your insurance cover you for when things go wrong with a tenant? Please call and find out about our bespoke landlords policy.
Congratulations to our Halloween competition winners who can find their winning entries published in the Evesham Journal on 3rd November. We had a fantastic response and many great pictures from across the age range. Well done to you all!
Did you know you can get live property updates from facebook? Throughout the day our facebook feed is updated with properties as they become available. Its quick and easy to join just go onto your facebook homepage and search for Timothy Lea & Griffiths.


CLEVELAND, Ohio -- Shake It Cerry is the 2-1 morning-line favorite for the $180,000 Cleveland Trotting Classic at Northfield Park on Saturday.
The second edition of the Classic kicks off a holiday weekend at Northfield that includes a special Sunday program.
Shake It Cerry drew the three post for the race. The 5-year-old mare has 28 career wins and earnings of more than $2.5 million, but has not won this season.
Obrigado, the runner-up in last year's Classic is 3-1 on the morning line, starting on the rail. Obrigado has won three of six starts this season, including the Charlie Hill Memorial at Scioto Downs on June 11.
One to watch is Like Old Times, the 2015 Ohio Horse of the Year, conditioned by Northfield Wall of Famer Don McKirgan. Like Old Times is a longshot at 25-1, but is coming off two straight wins at Northfield and broke the track record for 4-year-old trotting mares two weeks ago.
The Cleveland Trotting Classic, Northeast Ohio's premier trotting race, is the 11th race on the 15-race program Saturday. First race post time is 6 p.m. The undercard features Foiled Again, the richest horse in harness racing history and three-time Battle of Lake Erie winner in one of three $20,000 Open races.
The special 17-race Sunday program has nearly $600,000 in purses and features the best freshman filly pacers and trotters in Ohio. First race post time is 6 p.m.


Specialists in production and postproduction in various High Definition formats (2K, 4K and beyond), Victory International Production (VIP) is one of the oldest, most reputed production houses in the UAE, with resources to rival any large production firm. Serving a host of clients across a spectrum of businesses in the commercial and industrial sectors, we are the one-stop solutions vendor for post-production in video and film production in Dubai Media City. Over the years, our professional work ethics has given us the accountability and experience in the pan-Arab market.
Our lineup of work spans a gamut of films made for TV (dramas, documentaries, animation, etc), promotional videos and training programs for large corporations, marketing videos, videos designed for exhibitions, trade shows, curtain raisers for prestigious events, videos optimized for web marketing and branding, amongst a host of others.
Our bespoke state-of-the-art facilities and back-up, integrated design and solutions, and project management teamed with technical expertise that is unmatched gives us the unique edge. With strong industry alliances, in-house production and post-production facilities, We brings international quality service to our clients. With a young, pro-active and talented media team, Victory International Production brings the future of video-film production to Dubai.
Our technical advantage and precision delivery in executing a project was displayed spectacularly at our most recent accomplishment, viewed by millions across the UAE and the globe – the stunning capture and roll-out of the record-breaking New Year's Eve fireworks from the Palm Jumeirah and the World Islands.


Judaism and Christianity once were Islam, but people changed them.
Sig interviews Henry about the basis of his religious beliefs.
Nothing happens except by God's decree.
The Theory of Evolution as described in modern, mainstream science (that is macro evolution) is wholly incompatible with Christianity.


If there's a positive about the passing of President Bush is that the country was able to witness what genuine class and dignity looks like at a funeral.
That was the case with John McCain's funeral.
NY Post reports the funeral of George H.W. Bush brought together the nation's most exclusive club — every living president.
They sat side-by-side with their wives in the front row of Washington National Cathedral, a scene made for the history books, as George W. Bush sat across the aisle with his family.
Barack Obama, Bill Clinton and Jimmy Carter chatted easily among themselves before the service began and before the arrival of President Trump and first lady Melania.
Bill Clinton and former first lady Michelle Obama could be seen sharing a quiet conversation.
A few rows back, Chelsea Clinton was spotted in discussion with Ivanka Trump.


The American Massage Therapy Association's National Elections are now open through December 3, 2018. All Professional members are eligible to vote, and should have received their ballot and voting instructions by e-mail on November 15.
This year's slate includes massage therapists from across the country who bring a wealth of volunteer experience in both chapter and national positions to the AMTA Board of Directors. They also represent a mix of seasoned, experienced national board members, some who have been on the board for only a few years, and a new board member. They would all bring their energy and complementary skills to AMTA's national board.
If you have not received your ballot, contact Colleen Leeders to have your voting credentials re-sent.


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Home Politics Russian buildup near Ukraine gains steam, new satellite images show
Russian buildup near Ukraine gains steam, new satellite images show
Paul McLeary
Russia is stationing more tanks, mobile rocket artillery systems and advanced short-range ballistic missile batteries near the border with Ukraine, according to new satellite images released on Thursday.
The release of the images, taken by satellite company Maxar Technologies on Dec. 13, came hours after Moscow and Washington traded warnings over what might come next in the tense standoff. Yet representatives confirm the two sides are working toward a meeting next month in an attempt to reduce tensions.
Over 100,000 Russian troops have massed in an arc along Ukraine's borders, from Crimea in the south to its northeast frontier, complete with enough equipment and logistical backbone to make a quick push into Ukraine if so ordered.
A senior administration official, speaking to reporters on the condition of anonymity, said if Russian forces move into Ukraine, the U.S. and its allies "are prepared to impose severe costs that will damage Russia's economy and bring about exactly what [Russia] says it does not want — more NATO capabilities, not less, closer to Russia, not further away."
The remarks were the clearest to date that the Biden administration is considering moving troops and equipment around Europe to defend its easternmost NATO allies.
In response to any Russian incursion, the U.S. would "increase support for Ukraine's ability to defend its own territory and also to reassure our NATO partners and allies by changes in our force posture in frontline states," the U.S. official said. "All of that planning is well underway on our side and we're ready to act if and when it's needed."
During his annual year-end press conference Thursday, Russian President Vladimir Putin continued to build on the rhetoric he and his advisers used earlier in the week in a series of speeches at the Ministry of Defense headquarters.
Speaking to his military staff on Tuesday, Putin warned Russia could take "military-technical response measures and react harshly to unfriendly steps," if NATO didn't end its military training mission in Ukraine and stop equipping the Ukrainian military.
"It was the United States that came with its missiles to our home, to the doorstep of our home," he said on Thursday. "And you demand from me some guarantees. You should give us guarantees. You! And right away, right now."
Russia last week sent the U.S. and NATO a framework treaty, demanding the alliance pull back from bases in former satellite countries that are now NATO allies. Brussels and Washington flatly rejected the terms.
Walking away from Ukraine and shuttering bases in NATO countries close to Russia are proposals "we will never agree to," the administration official said.
"Most of Russia's demands target NATO and U.S. behavior, yet their military posture is pointed squarely at Ukraine," said Dara Massicot, a senior policy researcher at RAND Corporation and former Obama administration DoD staffer focused on Russian military capabilities. "Russia is using the threat of force and an artificially imposed diplomatic urgency to set the pace and force concessions, and is essentially creating a hostage situation."
Any fresh Russian incursion into Ukraine would be the second in a decade, after the 2014 invasion and annexation of Crimea. Over 13,000 people have died since then in eastern Ukraine, where Russian-backed separatists and troops have fought the Ukrainian government to a standstill.
Putin's comments at his press conference were aimed at a domestic audience, pressing the notion that Russian soil is being occupied by unfriendly Western regimes.
Lands that were historically Russian were carved out after the Soviet breakup and handed to Ukraine, Putin said, something Moscow could live with as long as Ukraine remained neutral.
But with several hundred NATO military trainers at a small base in the far west of the country, "they are creating on this territory an anti-Russia, with the constant sending over of contemporary weapons, brainwashing the population," Putin said. "Imagine the historical perspective of Russia for living from now on, to be always looking over our shoulders?"
Pentagon spokesperson John Kirby acknowledged this week that a small team of American military officials recently visited Kyiv to assess the country's air and missile defense needs, as Washington considers another round of military assistance.
Whatever the U.S. might try to provide in the near-term might be too late if Russia launches an invasion in the next several months, however.
"A multi-domain operation would be devastating for the Ukrainian military, which is why Kyiv is asking for more air defense support," Massicot said. She added that the talk in Washington about supplying Stingers, Patriot air defense systems and Javelin anti-tank weapons would have only "a marginal benefit at best against a Russian operation of this size, either due to technical reasons, or simply not enough numbers or enough time to deploy and integrate them."
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Birth control for wild horses is the obvious alternative to mass killing
This summer, the House Appropriations Committee voted for the first time to authorize killing healthy wild horses and burros. It did so with the full support of Interior Secretary Ryan Zinke, whose department bears the responsibility for managing wild horses on public lands.
We are appalled.
On one level, the vote to allow wild-horse killing is easy to understand. The Bureau of Land Management (BLM) scheme for managing protected wild horses and burros has never worked well, and has collapsed completely in the last 15 years.
Rounding up wild horses with helicopters and removing most of them for adoption is a strategy whose success depends on the whims of the horse adoption market, and works against wild horse reproductive biology. Adoptions have not kept up with removals, and removals have not kept up with natural growth of wild horse populations on the range.
Today, 46,000 formerly free-roaming wild horses are warehoused in holding facilities, costing taxpayers $60 million a year and counting. At the same time, according to the BLM, the number of horses and burros on the range has more than doubled since 2005-2008.
Something must be done to break out of this costly cycle of futility. Hence, the committee vote. Still, on another level, the committee's action is bafflingly disingenuous and shortsighted. As a former congressman and governor from the West and a scientist and advocate who share more than a quarter century of engagement with the wild horse issue, we do not believe there is any chance that the public will allow killing of healthy wild horses on this scale. Historically, public outrage has routinely blocked far lesser abuses.
But if other issues conspire to divert public attention from horse-killing, the 20 percent annual growth rate shown by wild horse populations on public lands would refill BLM's holding facilities to current levels in a mere three years. The killing strategy is no more sustainable than the roundup and adopt strategy.
The wild horse challenge cannot be solved unless wild horse reproduction is managed on the range. Less than a mile from where the House Appropriations Committee debated killing wild horses, experts from all over the world participated in the eighth International Conference in Wildlife Fertility Control. There, researchers from Cummings School of Veterinary Medicine at Tufts University, The Humane Society of the United States and the University of Toledo presented data from field trials showing that two doses of a contraceptive vaccine (known as PZP) delivered several years apart can block wild horse pregnancies for five years or longer. The vaccine costs a few hundred dollars for the first dose, but only $25 for the second.
Another research group from Colorado State University, the National Park Service and USDA's National Wildlife Research Center showed remarkably similar data from wild horse field trials with a different contraceptive vaccine (known as GonaCon). These vaccines, and the data describing their safety and effectiveness, are both well known to the BLM, which has been funding such research for decades. Side effects are minimal, mostly consisting of short-term reactions at the injection site experienced by some horses.
Researchers can still improve these vaccines, and are eager to do that. But it is the job of the BLM to inject these vaccines into enough horses to slow down population growth. Working with the BLM at Cedar Mountains Herd Management Area in Utah, the Tufts/HSUS/Toledo research team showed that it can be done. Enough mares were treated with PZP at a 2012 BLM gather to reduce annual population growth to about 8.5 percent over the two years following — a third of the normal growth rate at that site.
Cedar Mountains is a tough place to work, covering 280 rugged square miles, nearly 60 percent of which is wilderness off-limits to vehicles. If BLM can do it there, they can do it nearly everywhere.
To reduce the number of gathers and the flow of animals into holding, improve the health of the range long-term and find its way out of its perpetual wild horse crisis, the BLM must develop and put into practice locally tailored long-term plans to manage wild horses and burros with fertility control.
Instead of funding horse killing, Congress should insist that management by fertility control gets done, and provide the BLM with the cash to do it.
Bill Richardson has served as a U.S. congressman (1982-1996), U. S. ambassador to the United Nations (1997-1998), secretary of Energy (1998-2000) and governor of New Mexico (2003-2011). With actor and conservationist Robert Redford, he started the Foundation to Preserve New Mexico Wildlife to protect wild horses and provide alternatives to horse slaughter.
Allen Rutberg is director of the Center for Animals and Public Policy at Cummings School of Veterinary Medicine at Tufts University and a long-time wild horse contraception researcher.
Source: The Hill
Caring for Horses in the Navajo Nation
A synopsis of a presentation to veterinarians during The American Mustang session at the 2014 American Association of Equine Practitioners Convention, held Dec. 6-10 in Salt Lake City, Utah.
Feral tribal horses walk the streets within the Navajo Nation. They're outside restaurants. In people's yards. There are just too many horses, and the Navajo government is working to change that. It started in 2013 with community roundups and a veterinary management program.
Scott Bender, DVM, works as tribal veterinarian with the Navajo Nation Veterinary Program and is a USDA Animal and Plant Health Inspection Service consulting veterinarian. At the 2014 American Association of Equine Practitioners Convention, held Dec. 6-10 in Salt Lake City, Utah, Bender shared the challenges faced when managing feral horses within the Navajo Nation and results of tribal equine population management efforts.
The Navajo Nation is located in the southwestern United States, with territory spanning Arizona, Utah, and New Mexico. The reservation comprises 18 million acres and, said Bender, an estimated 75,000 to 96,000 horses.
The tribe permits 12,000 livestock owners, with the majority of permit holders having one to five privately owned horses.
Under tribal law, all unbranded horses within the Navajo Nation are tribal property, Bender explained. That leaves the tribe with a lot of horses.
The Navajo traditionally view horses as sport, working, and food animals. "The horse is sacred to the Navajo, but that doesn't mean we don't eat them," Bender explained. The Navajo believe horsemeat has medicinal, healing properties and is useful as a "winter" meat, he said, explaining that "horsemeat, by tradition, can only be eaten in the winter between October and April—end of thunder and not after 'first thunder.'"
Initially and into the early 20th Century, the U.S. Bureau of Indian Affairs managed tribal livestock, but management has slowly transitioned to the sovereign nation government, Bender said. This happened partly because of U.S. government-approved reduction of livestock in the 1930s and the euthanasia and burial of more than 500 horses by federal authorizes following a dourine outbreak at the Canyon de Chelly National Monument, which is located in northeastern Arizona within the Navajo Nation boundaries. "This 'waste of resources' has left a negative indelible mark on the attitude of Navajo livestock owners toward the U.S. government," Bender said.
To the Navajo, unused horsemeat is a wasted resource that the creator gave the people, he clarified.
With this in mind, surplus Navajo horses had historically been sold off-reservation to slaughter as a way to manage populations and produce income. When U.S. equine slaughter plants closed in 2007, the tribal horses lost 95% of their value and the surplus feral horses were left to breed without human controls, Bender said. "The current (tribal) horse issue is a direct result of the elimination of an outlet for surplus horses," he added.
As herds grew, damage to rangelands increased, as did horse-caused human injuries. "Horses in right-of-ways caused car wrecks, human injuries, and even deaths," Bender said. These issues led tribal communities to request that the Navajo National Department of Agriculture start its equine population management program in 2013, which involved roundups and veterinary services, including free:
Stallion and colt castrations;
Mare fertility control via porcine zona pellucida (PZP) vaccination;
Deworming for all castrated or fertility-control-vaccinated horses;
Five-way vaccination against tetanus, Eastern and Western encephalomyelitis, equine herpesvirus, and equine influenza; and
Microchip placement (since 2006, the tribe has mandated microchips, which are placed in the nuchal ligament along the neck so as not to taint the horse's meat should it be sold or eaten, Bender said; the Navajo Nation has microchipped more than 18,000 horses since 1997).
While the initial fertility vaccination was effective, Bender described owner booster rates of horses as "dismal," despite the program's outreach and communications efforts promoting boosters. The program's leadership is now investigating anti-gonadotropin-releasing hormone vaccine (know more commonly as anti-GnRH or GonaCon) use as a longer-activing and single-dose alternative to PZP.
In 2013 the Navajo Nation local communities, with the help of the Navajo Nation Departments of Agriculture and Resource Enforcement, rounded up more than 8,900 horses. Permitted owners claimed approximately 250 horses, with the tribe selling the rest with the requirement that they could not be returned to the Navajo Nation.
The veterinary program's goal was to castrate 1,000 male horses and vaccinate 1,500 mares against fertility by the end of 2014. To date, more than 700 horses have been castrated or vaccinated with PZP for fertility control. Bender said members of communities where horse removals took place have reported improved forage conditions in spite of the continuing 14 years of drought in the southwestern United States and Navajo Nation.
Source: The Horse
Fertility Control Study in National Park Service Mares
The National Park Service (NPS) is currently studying the use of fertility control vaccines to control feral horse populations on NPS lands.
Jenny Powers, DVM, PhD, an NPS wildlife veterinarian, shared preliminary results during a presentation at the 2014 American Association of Equine Practitioners Convention, held Dec. 6-10 in Salt Lake City, Utah.
Managers at Theodore Roosevelt National Park in North Dakota are seeking ways to control feral horse populations that include alternatives to helicopter roundups and sales.
The horses, which some consider culturally significant and suggest are the origin of the Nokota breed, share the same range as elk, pronghorn, mule and white-tail deer, and bison in the 46,000-acre park, necessitating careful resource allocation and equine population management, Powers said.
In October 2009 NPS started a study using a gonadotropin-releasing hormone (GnRH) immunocontraceptive vaccine on mares in the park. First, park managers rounded up and removed half the park's horses. They then blocked the remaining mature mares by age, body condition, and reproductive status. They separated the horses into a treatment group of 29 and a nontreatment group of 28 individual mares.
The treatment group received 2 mL of GnRH vaccine. The control group received 2 mL of saline. Most mares were pregnant at the time of treatment. "The GnRH vaccine we used showed promise as a multiyear vaccine after giving a single dose," Powers said. "This is highly unusual for a vaccine to work for more than a year and would greatly improve the efficiency over currently available fertility control vaccines."
Over the next four years, NPS researchers observed the mares for:
Foaling rates;
Foal survival;
Mare body condition;
Mare reproductive behaviors; and
Time budgets, such as time spent eating, moving, resting, or doing other behaviors.
In the first foaling season, 2010, researchers saw no statistical change in foaling or foal survival rates, as was expected because most animals were pregnant at the time of vaccination, and there was no difference in foal survival between treated and control mares, Powers said.
In the second foaling season (the first expected to be affected by vaccination), the proportion of treated mares that foaled was 35% less than untreated mares. The third foaling season saw the proportion of treated mares that foaled 30% less than untreated mares. But the fourth foaling season, researchers observed no statistical difference in foaling rates between treated and untreated mares.
NPS managers observed minimal changes to reproductive behaviors or time budgets, Powers said. Of the treated mares, 80% had injection site swelling one to four years after treatment.
Overall, NPS researchers found a single vaccination with the GnRH vaccine provided a modest decrease foaling rates for two years post-vaccination and had little effect on social behaviors, she said, adding that treated mares had no more or less reproductive interaction with stallions than untreated mares.
She also said treated mares did have apparent inflammatory reactions at injection site, but this did not appear to affect their well-being, as they did not become lame or lose body condition.
"The NPS is currently studying the efficacy of revaccination four years after the first vaccination, and researchers are interested in how long a booster vaccine might last and how effective it can be at preventing pregnancy," Powers concluded.
Click Here to view white paper, presented at the AAEP conference


Most people believe that Yamaha built the first purpose-built four-stroke works bike to take advantage of the AMA's four-stroke exemption rule.
They are wrong. This KTM 620SX, reconfigured to 538cc, was the first four-stroke to ever qualify for an AMA Supercross main event.


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The FCA 2019-2020 Annual Report and Accounts: Everything you need to know
The FCA 2019 - 2020 Annual Report and Accounts: Everything you need to know
On 10 September 2020, the Financial Conduct Authority (FCA) published its Annual Report and Accounts 2019/20 (the Annual Report), which outlines the achievements and activity of the FCA during the last year.
It sets out how the FCA has used its resources and how it has tried to meet the various strategic and operational objectives set by Parliament.
But aside from the impact of the Covid-19 pandemic, has anything changed from last year?
Here is our summary of the key takeaways from the Annual Report and an analysis of whether it provides any insight into next year's direction of travel.
Key trends – cross sector priorities
The Annual Report delves into the cross-sector and sector priorities of the FCA, outlining whether they have been, or will be, met throughout the year.
This year, the FCA's enforcement focus, which is set out in its Business Plan 2020/2021, remains largely unchanged. It's clear from the Annual Report the FCA is backing up its emphasis on conduct and culture in the financial sector with action.
For example, it has increased resource spending in its dedicated whistleblowing team, which received 1,153 individual reports last year. The FCA took action to prevent harm in 218 of those cases while 691 cases still remain to be assessed. But while the FCA is encouraging individuals to speak out, it is going to need to devote additional resources to assessing these reports. This could potentially increase the time it takes to investigate and resolve matters – something which is already one of the industry's main bugbears.
Another example of increasing resource spending to meet a key priority in the Annual Report is the focus on anti-money laundering (AML). The FCA hosted an AML and financial crime TechSprint event with participants from 16 countries. Its aim was to develop technological concepts that would help protect privacy and detect financial crime.
This action has allowed the FCA to share intelligence with other relevant agencies and increase understanding of its risks, helping it work towards meeting its key priorities regarding AML.
Conversely, the FCA has made some necessary concessions in its approach to AML. A recent freedom of information request revealed the FCA has shut down half of its open AML investigations – reducing the chance of a first prosecution under the money-laundering regulations. While it is still dedicated to funding AML intelligence activities, it remains to be seen whether this will translate into AML criminal cases as expected.
Finally, the FCA has invested in its ScamSmart campaign, showing its continued focus on preventing financial crime against the vulnerable. It has also connected with younger audiences thanks to a strong push across social media sites.
A breakdown of the facts and figures
The Annual Report offers some context about the FCA's financial position, which can give us an idea of how its resources are being used on a year to year basis.
The FCA's permanent staff headcount in its Supervision and Enforcement teams increased slightly compared to last year.
The value of financial penalties issued to 1 April 2020 remains broadly the same as last year, at £224.4m across 15 individual penalties.
59 s166 Skilled Person Reports were commissioned in 2019/2020. A large portion looked at retail lending and banking, with substantial focus on investment management and wholesale markets as well. This illustrates the FCA still favours this supervisory tool.
The FCA Business Plan 2019/2020, which provides a detailed outlook of the FCA's budget for the year, tells us its budget has increased. Its budget for 2019/2020 was £558.5m, up by 2.7% on the previous year.
Several factors influence this budget, including the amount the FCA charges the industry to fund its activities, the cost of the FCA's operating activities, and how much capital it is spending on developing new technology and information systems.
Adapting for Covid-19
Like many other regulators, the FCA has had to urgently divert resources to addressing issues thrown up by the Covid-19 pandemic. New measures have included issuing emergency guidance to a number of different sectors to ensure vulnerable customers are protected and have continuous access to banking services. In addition, it gave a level of clarity to many business owners by bringing its business interruption insurance test case to the fore.
The FCA also spent significant time monitoring the market and increasing its firm and trade-body engagement. But as a result of this diversion of resources, some of its thematic supervisory work has been delayed, and various consultations have been pushed into Q3 2020.
Covid-19 is not the only significant external factor changing how the FCA regulates – although the FCA was, at least, able to anticipate and plan for this significant change. The Annual Report sets out the FCA's intention to maintain its influence as a leading global regulator, even after the UK's withdrawal from the EU.
The FCA hopes to help smaller businesses adapt following the EU withdrawal. To do so, it will dedicate significant resources to rolling out the Temporary Permission Regime, which will allow firms to continue cross-border activity in the UK after the transition period ends.
The Annual Report underlines what the FCA is hoping to focus on in the future when it comes to both risks and investments.
It is investing in technology to improve its operational capacity, which should make the FCA more flexible and efficient. It is also looking into potentially implementing cloud-based virtual datacentres to improve the quality of its data analytics.
The FCA is still asking experienced supervisors and enforcement staff to carry out relationship and investigation work, with workloads seemingly increasing.
Despite the apparent decrease in AML cases, financial crime and culture/conduct remain key aspects of focus for the FCA. It's likely we'll see more of these enforcement cases as decisions are published later this year.
However, a number of areas of concern for the coming year were also identified by the FCA.
There is particular concern about how firms failing because of the pandemic will be able to pay fees to the FCA.
The FCA also has concerns that potential and current projects could be delayed and resources reprioritised due to the impact of the coronavirus. This could mean it struggles to achieve some of the outcomes and priorities identified in the Annual Report.
The Annual Report shows that the financial position of the FCA remains strong, and objectives and key priorities are being met. However, some concern remains about the ongoing impact of Covid-19 on its supervisory and less urgent work, which could continue well into the next financial year.
This publication is intended for general guidance and represents our understanding of the relevant law and practice as at October 2020. Specific advice should be sought for specific cases. For more information see our terms & conditions.
By Michael Ruck
Consumer Finance: Hot Topics for 2020
The countdown to Brexit and beyond - US/UK trade what next? A view...
TLT advises Thrive on first commercial rooftop solar initiative
TLT wins Best Law Firm at Car Finance Awards
Working with UK and international banks on domestic and cross-border debt finance activity.
We advise across the whole spectrum of business and trading arrangements.


Citation:Kimberly Denney (2016) Improving Physician Acceptance of Alerts with Closed Loop Analytics. J Nursing Palliat serv 1:101.
Copyright: © 2016 Kimberly Denney, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Previous research identified the average primary care physician sees more than 60 alerts per day requiring nearly an hour of their clinic time to manage. With 90% of those alerts considered unwarranted, improved clinical decision support (CDS) tools are vital to supporting transitions to value based care and the active engagement of providers. A recent quantitative correlation study focused on physician perceptions of computerized physician order entry (CPOE) alerts found a statistically significant affect between elements of alert design and perceived value in improving adherence to accountable care organization (ACO) quality measures. Application of sociotechnical considerations in the design of provider alerts coupled with near-real-time analytics provides organizations assuming greater financial risk with tools to reduce waste and inappropriate care while supporting improvements in care quality. Advancements in alert analytics supports organizations in closing the loop with their providers to achieve a clinical and financial return on their investments in the electronic health record (EHR).
The abstract along with a presentation of related findings from my doctoral dissertation  was shared at a Healthcare Informatics Conference in Las Vegas . While conducting quantitative survey based research as part of my doctoral business studies, I was employed by a start-up healthcare information technology company, privately funded and incubated at Cedars Sinai Health System in Los Angeles, CA. My research aligned with product development efforts underway at Stanson Health, Inc. The firm is advancing the art of CDS tools for providers through the development of sophisticated clinical algorithms deployed as provider notifications at the point of care in the EHR with associated, near real-time alert analytics .
As U.S. health care reform shifts reimbursement from a fee-for-service model toward reimbursement based on outcomes, ACOs comprise part of the national strategy for achieving health care's triple aim of providing better and safer care at lower costs [4,5]. For alternative care models such as ACOs to succeed, numerous researchers highlighted the need for more sophisticated healthcare information technology (HIT) systems and tools.
A heat map published by Leavitt Partners in 2014 depicted the beginning of an unstoppable wave of transformation as approximately 500 ACOs were identified. More recent estimates place the number approaching 800 and spanning as many as 23.5 million lives under Medicare, Medicaid and private insurers . Although still in the learning stages, a number of early ACOs achieved notable success in improving quality while reducing cost. Leavitt Partners estimated 105 million people could be covered by ACOs by 2020.
With an understanding of these important forces, I examined earlier published work related to CDS applications. Sittig and Singh (2010) shared a socio-technical framework applicable for health systems deploying CDS in the EHR. CDS viewed both as a tactical and strategic tool is especially suited to serve organizations preparing for down-side risk based agreements. Effectively designed CDS can aid clinicians in making clinically relevant decisions, and it is one of the few proven ways organizations can actually change clinician behavior.
With billions of dollars invested in EHRs in the US, how do we unlock the value of that investment? I chose to examine physician perceptions for the potential of CDS to support better patient care through support of adherence to ACO quality measures. In the past, many CDS tools were used referentially. That is, they required the clinician to stop and exit the clinical workflow to look something up in a journal, textbook, or online resource. By integrating CDS tools in the clinical workflow, we can assist providers to access the right clinical and patient data in real-time supporting more efficient decision making.
Why the emphasis on integrated CDS with an EHR system?  published a landmark study in the BMJ. Across several thousand physicians, the authors examined the ways physicians receive information and which method of interceding with information had the greatest impact on decision making. They found that automating decision support in the clinical workflow succeeded as an intervention 75% of the time whereas no other intervention resulted in supporting providers to change their minds.
To examine physician perceptions that EHR alerts might support efforts to improve adherence to reportable quality measures for their ACO patients, I designed a quantitative correlation study. Borrowing heavily from the published literature on alerts and accessing my professional network of HIT experts, I designed a likert-type scaled instrument administered online (via Survey Monkey) with anonymous participation by subjects. The Association of Medical Directors of Information Systems (AMDIS) served as my doctoral research community partner and supported my efforts to recruit survey participation.
The final instrument was designed with 3 scales, one for each of the three variables in the study. The regression model contained 2 independent (predictor) variables forming a construct for the content of an alert in the clinical workflow of an ordering physician and the timing of presenting the alert during CPOE. The third scale was aligned to the dependent variable. The third construct enabled assessment of the physician's perception of alert characteristics (content and timing) with ACO quality measure adherence.
The purpose of applying sociotechnical design to complex organizations such as healthcare systems arises from an understanding that harm may result from both human and technical factors . A sociotechnical framework assists software developers in addressing complex systems through an improved understanding of the communication patterns, workflows, and tools required by users across the system [8,9].
My research premise was that understanding physician's preferences of alert attributes deployed in their workflow would provide software developers fresh insights for improving CDS tools. Sittig and Singh's  sociotechnical framework aligns well with  three- phase depiction of an EHR enabled healthcare system characterized by the use of sophisticated HIT systems and tools that improve the quality and safety of care.
A prospective sampling approach was used recognizing the need to survey a homogeneous population. The subjects recruited for the study were physician executives using an Epic or Cerner EHR in a hospital affiliated with an ACO. At 80% power determined with G*Power software, 68 completed surveys were required.
Walden University's IRB provided approval to test the self- developed instrument in a small pilot with 5 physician executives. I validated the constructs and the instrument through the pilot. The IRB further required I enlist a community partner for recruitment of my subjects. AMDIS assisted by sharing my request for participation with a hyperlink to the online survey from their member list serv. Over a 3week period in June 2015, I recruited a sufficient number of subjects to meet the required sample size.
126 physicians attempted the survey. The first 4 survey questions determined inclusion. Any "no" response among the first four questions resulted in termination of the survey. The first question was acknowledgement of the informed consent. The next 3 questions confirmed status as MD or DO, ACO affiliation, and EHR use type.
Compared to the .80 alphas I obtained in the pilot, the cronbach alphas degraded to the low 60's upon completion of the full survey. As this was a new research instrument, lower alphas are acceptable. It is possible that I obtained skewed results in the pilot since the invited subjects were known to me as experts in the field. Additionally, all 5 pilot physician executives were using an Epic Systems EHR whereas 1/3 were of subjects were Cerner Incorporated EHR users in the final study.
At the conclusion of the study, all statistical analysis was performed using SPSS. The overarching research question sought to determine the extent to which sociotechnical factors addressed in the design of CDS software tools affected physician ordering behaviour. The results of the model were significant with R2 = .108, F (2,66) = 3.99, p = .023.
Furthermore, a significant correlation was found between independent variable A (alert content) and the dependent variable (quality measure adherence). Therefore, the null hypothesis was rejected: r = .326, p < .003. However, No significant correlation was identified between the independent variable B (alert timing) and the dependent variable resulting in acceptance of the null hypothesis: r = .037, p > .05.
Certain attributes of alert content such as alignment with evidence and specificity to a patient's clinical and medical status are perceived as beneficial in an alert. Physician nonadherence to alerts due to issues of alert fatigue and information overload is well documented in the literature [11-13].
Previous research identified that primary care physicians saw more than 60 alerts per day requiring nearly an hour of their clinic time to manage . In a follow up survey, physicians claimed nearly 90% of alerts were unwarranted with 2/3 of the physicians reporting they could not manage the volume of alerts they triggered daily .
Interestingly, the content related survey questions resulted in high uniformity of responses with physicians agreeing with sociotechnical aspects of the content to be included in a clinical/order based alert. Only 3 subjects disagreed that alerts should be driven from patient specific data contained within the record, alerts should be prepopulated with evidenced based override reasons, and should contain links to patient education materials when available. Surprisingly, nearly 1/3 of subjects disagreed that alerts should include links to supporting evidence. It may be the case that once a provider has been told the provenance for the recommendation comes from a medical society or provider led entity, they no longer see the necessity to access a link to the underlying body of evidence.
Other findings included a 90% agreement across subjects that alerts should be placed into their workflow to improve their adherence to ACO quality measures. However, the respondents were nearly evenly split in regards to the specific aspects of ideal workflow timing. There was no consensus as to whether alerts should be allowed to pop up as they are triggered in an ordering session or held until the end. For software developers, the sociotechnical dimension related to understanding clinical workflow timing is frequently cited as a significant and complex challenge in the design and adoption of software tools [8,10,16-18].
Physicians were evenly split (for or against) in their preferences for the use of a passive alert notifying them that the ACO patient met criteria such as diabetic, with heart failure, or other cardiovascular and peripheral disease. The study was not powered for a subset analysis by EHR type although a trend toward a difference in response was noted. A few limitations are especially worthy of noting. First, the Workflow Timing Construct was limited to 3 questions in the survey instrument. Second, the Alert Timing Window was narrowed to just the period of Computerized Physician Order Entry (CPOE). Third, all responses were constrained to the Physician's workflow. Finally, there were no considerations given for workflow alerts for nurses and other care team members or for the use of asynchronously timed alerts.
Recognizing the EHR consolidates vast amounts of patient and clinical data for purposes of supporting better-informed clinical decisions, software vendors unintentionally developed solutions that contributed to fatigue or burnout increasing the risk for patient harm. The research findings suggested a preference for robust clinical algorithms in the design of alerts focused on content containing patient specific factors and the latest evidence based guidance. By focusing alert design on the characteristics physicians viewed as positive, we might design "fatigue proof" alerts coupling them with additional analytic tools to assist in dialing down the alert activity and noise presently viewed by many providers as problematic and non-value add.
•Translating evidence and best practice guidelines into actionable and understandable point of care recommendations.
•Ensuring alerts correctly interrogated relevant patient and clinical data before interrupting the physician's ordering workflow.
•Exploring the asynchronous timing of alert delivery to potentially lessen concerns of alert fatigue.
•Tailoring CDS by treatment venue and specialty with further application of sociotechnical factors.
To close the loop on understanding a provider's behaviour and interaction with alerts, the use of a cloud-based analytics platform can be coupled with EHR embedded CDS . As the physician interacts with the alert, the analytics engine records this information. Subsequently, with a nightly download of order data from the EHR, these interactions are run through additional algorithms that permit the data to be reflected in user configurable dashboards and reports. Several use cases exist for combining closed loop analytics with real-time workflow alerts. At a high level, the health system can determine how a specific alert is performing over time, the percentage of providers who adhere to an evidence based recommendation, and which providers ignore or override the recommendation and why. To fully close the loop, one needs to be able to assist an individual provider in understanding their behaviours in relation to their peers. In the past, a physician might have told his director he did not know why his outcomes were different than his peers. In the future, with more granular alert data accessible we might be able to lend meaningful insight to that discussion. An open question remains whether or not ignoring or overriding evidence based recommendations at a rate significantly different than one's peers contributes to different patient outcomes.
The significant relationship identified between alert content and physician perception of improved adherence to ACO quality measures suggests the design of CDS software tools might support improvements in the management of high-risk patients enrolled in ACOs. The findings from this research when applied to improving CDS tools might enable organizations with significant investments in HIT to realize clinical and financial benefits through improved ACO clinical and financial performance. Improving the decision support tools for physicians managing ACO patients might support the vision of a technology enabled health care system that transforms clinical data for active decision making for the benefit of health care providers, patients, and their families. In conclusion, there remains much work to be done to better understand user needs and design tools enabling clinicians working in the EHR to improve the quality, safety, and cost of care. These efforts become increasingly important as we hasten down the path of providing payment for healthcare based on value and the outcomes obtained.
Denney KB (2015) Assessing Clinical Software User Needs for Improved Clinical Decision Support Tools (Doctoral dissertation, WALDEN UNIVERSITY).
Denney K (2016) Improving Physician Acceptance of Alerts with Closed Loop Analytics.Conference Proceedings J. Health Med Inform 7: 3.
Stanson Health, Inc. Los Angeles, CA 90024.
Berwick DM (2011) Launching accountable care organizations—the proposed rule for the Medicare Shared Savings Program. New England Journal of Medicine 364.
Burwell SM (2015) Setting value-based payment goals: HHS efforts to improve US health care. New England Journal of Medicine 372: 897–899.
Leavitt Partners white paper: The Projected Growth of ACOs (2015).
Kawamoto K, Houlihan CA, Balas EA, Lobach DF (2005) Improving clinical practice using clinical decision support systems: A systematic review of trials to identify features critical to success. British Medical Journal 330: 765.
Sittig DF, Singh H (2010) A new sociotechnical model for studying health information technology in complex adaptive healthcare systems. Quality and Safety in Health Care 19: i68–i74.
Path AS (2013) Safer path forward for medical device interoperability needed, per new AAMI Report. Environment of Care News, 16(4).
Meeks DW, Takian A, Sittig DF, Singh H, Barber N, et al. (2014) Exploring the sociotechnical intersection of patient safety and electronic health record implementation. Journal of the American Medical Informatics Association 21: e28–e34.
Bowman S (2013) Impact of electronic health record systems on information integrity: Quality and safety implications. Perspectives in Health Information Management, 10(Fall).
Menon S, Smith MW, Sittig DF, Petersen NJ, Hysong SJ, et al. (2014) How context affects electronic health record-based test result follow-up: A mixed-methods evaluation. British Medical Journal open 4: e005985.
Smith M, Murphy D, Laxmisan A, Sittig D, Reis B, et al. (2013) Developing software to "Track and Catch" missed follow-up of abnormal test results in a complex sociotechnical environment. Applied Clinical Informatics 4: 359.
Murphy DR, Reis B, Sittig DF, Singh H (2012) Notifications received by primary care practitioners in electronic health records: A taxonomy and time analysis. The American Journal of Medicine 125: 209.
Singh H, Spitzmueller C, Petersen NJ, Sawhney MK, Sittig DF, et al. (2013) Information overload and missed test results in electronic health record–based settings. Journal of the American Medical Association Internal Medicine 173: 702–704.
Perna G (2012) Clinical alerts that cried wolf: As clinical alerts pose physician workflow problems, healthcare IT leaders look for answers. Healthcare Informatics 29: 18–20.


DID you know that Feb 17 is random act of kindness day?
making a WHOLE week of it!
Well I was all over that! we could make this a monthly thing michaels. me and you and crafts…true love forever.
I ended up grabbing all the stuff to make this gorgeous spring wreath with fun frame!
First thing i made: a wreath! this giant wreath was only $9–and michaels had a 40% off coupon…so I got it for a steal of a deal!
I wrapped some bakers's twine around the frame…and added some chip board letters for the HI! hot glued some real flowers and fabric flowers around the edge and folding in some strips of burlap..
and I had some of this mesh…and thought the randomness was fun and turned them into leaves!
just hot glued some chicken coop wire to the back….
and michaels had this wall of hair crap just waiting for me….
(pretty sure angels were singing…just saying.) This wall was the only time I thought….100 bucks was not enough. I wanted them ALLLLLLLLLLLL.
i snipped off the stems and added a clip with hot glue…done and done.
or to hold notes…or recipes or pictures…so cute in a kids room!
okay…last but not least….bought this cute little frame..
I had so much fun! I hope all this fun stuff will help out lot's fundraiser!


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Home » Best Outcomes Model » How Do You Measure the Success of an Animal Training Program?
How Do You Measure the Success of an Animal Training Program?
There is no one right training system or simplified cookbook of techniques that will provide the best possible outcome given all the different factors of each species and the human objectives involved. Instead, knowing which techniques to use and when to use them is a matter of degrees and variables and greatly depends on the context of the situation. Training and teaching is always individual: a study of one (as Dr. Susan Friedman puts it). Ultimately, it is the goal of any managed care (captive) environment to provide optimal welfare and happiness for the animals while living within the constraints of the situation. This will mean choosing a holistic approach to care that balances the needs of the animal and the trainer. Technique choice, handling methods, environment, medical care and training objectives are all examples of choices that must be taken into account when determining the overall well-being of the animal. So how do we know if we are doing a good job? How do we measure if the balance has been well struck?
At ATR Int'l, we judge our techniques and choices on the measurable and definable net effect on our animals' relationships with the trainers and the system. There are several behavioral indicators we look for in our animals that let us know our relationship bank account is high and the animals are happy and in good welfare.
Is the animal engaged and interested in people and interactions?
Does the animal's behavior indicate that it wants to participate by approaching eagerly without any coercion?
Does the animal choose to cooperate in free space with no control (such as leashes, halters, jesses, etc.)?
Does the animal's behavior and body language indicate that it is calm, comfortable, and relaxed during training and outside of a session?
So now a question for discussion: what specific characteristics or specific behaviors do YOU look for in your animals (please state the species) that you use that indicate your choices are/have been effective in managing this best outcomes balance?
By slewths in Best Outcomes Model, Transformative Learning Education Model, Uncategorized on March 11, 2017 .


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WIU Home > COFAC > Music > Faculty Staff Info
School of Music Faculty
Kevin Nichols, D.M.A.
Associate Professor, Jazz Studies, Percussion
Sallee 102
Email: KA-Nichols1@wiu.edu
Visit: http://www.wiu.edu/percussion
Kevin A. Nichols, Associate Professor of Music at Western Illinois University, teaches applied percussion and percussion methods course, coach jazz combos, and is the Drumline Instructor/Arranger for the Marching Leathernecks. Outside of WIU, he is active as a performer, director, clinician and adjudicator throughout the Midwest and Southwest.
Active as a performer, Dr. Nichols has supported such notable artists as Marie Osmond, Evelyn Glennie, David Amram, Jim Rattigan and the Turtle Island String Quartet. Additionally, he is a section percussionist, assistant timpanist, and drumset specialist with the Peoria Symphony Orchestra. In addition to section duties, he was the symphony's featured percussionist on their performance of Darius Milhaud's La Création du Monde and Aaron Copland's Music for Theatre. Other symphonic performance accomplishments include University of Iowa Symphony and Chamber Orchestras, Knox-Galesburg Symphony, and Galesburg Symphony Chorus.
Active on the drum set, he is a member of the John Cooper Jazz Orchestra, Peoria Heritage Ensemble, Savoy Stompers, and the Matt Warnock Trio. His WIU performances include solo recitals, the Faculty Chamber Series, and Summer Music Theatre. Dr. Nichols is also a founding member of the resident faculty jazz combo, the Hopper Jazztet.
Dr. Nichols has been a presenter for both Iowa and Illinois Music Educator Association All-State conferences, the Illinois Chapter of the Percussive Arts Society, and the Taos (NM) Youth Music Group. As a director he is the former Director of the Central Illinois Youth Percussion Ensemble in Peoria, and has led Concert and Marching Percussion Ensembles throughout the state of Illinois. During the summer months, he is a Percussion Instructor for the WIU Summer Music Camps. Dr. Nichols has adjudicated events for the Percussive Arts Society, University of Missouri, Illinois High School Association, Illinois Music Educators Association's All-State Convention and various marching and jazz competitions throughout the region.
Dr. Nichols has completed coursework towards a Doctor of Musical Arts degree at the University of Iowa. His research focal point is compositions written for drum set as a multi-percussion instrument. Presentations of his research have been hosted by McKendree University, Kansas State University, Oklahoma City University, Bradley University, and Chicago State University. He holds two Master of Music degrees from Northwestern University, in Jazz Pedagogy and Percussion Performance, as well as a Bachelor of Music degree in Percussion Performance from Illinois Wesleyan University.
Dr. Nichols is a member of the PAS Drumset Committee and a former officer for the Illinois Chapter of PAS. He is a member of M.E.N.C., C.M.S., and Phi Mu Alpha Sinfonia.
Dr. Nichols is an Educational Artist for the Avedis Zildjian Cymbal Company and Remo, Inc.
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