text:
BLADDER EXTROPHY: FROM ENVIROMENTAL TO MOLECULAR APPROACH
Author: Enrico Checcucci
The bladder estrophy is usually included in bladder exstrophy-epispadias-complex (BEEC): an
anterior midline defect with variable expression that affects the infraumbilical abdominal wall including the pelvis, urinary tract, and external genitalia. It ranges from isolated epispadias (E), to classic bladder exstrophy (CBE), to its most severe form, cloacal exstrophy (CE) also known as OEIS complex (omphalocele, exstrophy of the bladder, imperforate anus, spinal defects).
Prevalence at birth ranges from 1/30,000 for CBE to 1/200,000 for CE. There is a greater proportion of affected males than females, ranging from 1.8:1 to 6:1. While the etiology of BEEC remains unknown, strong evidence exists linking its development to genetic effects. The etiological association of genetic determinants is supported by the discrepant male to female ratio; a 400-fold increase of the recurrence risk for offsprings of affected individuals;
observations of rare multiplex families; and much higher concordance rates (62% vs. 11%) among monozygotic as compared to dizygotic twins. Its non-Mendelian pattern of segregation and the incomplete concordance among MZ twins implies a complex trait model of inheritance.
EMBRYOGENESIS OF THE URINARY TRACT
The urinary tract is formed by three components:
1) the kidneys which, originate from the metanephros
2) the upper urinary tract (ureters, cups, tubes), which originate from the mesonephros
3) the lower urinary tract (urethra and bladder) that originate from the urogenital sinus (endoderm).
The development of the urogenital sinus starts from the fourth week when the cloaca is divided into a anterior portion, the urogenital sinus precisely, and a posterior portion from which is going to born the rectum. The cloaca during the four week goes to occupy a ventral position forming the abdominal anterior wall.
The urogenital sinus at the top extends towards the allantois, while at the bottom is temporarily closed from the urogenital diaphragm, which will break during the seventh week, putting it in communication with the amniotic fluid.
The development of the bladder takes place between the fourth and seventh week, while there is the septation of cloaca, the walls of the urogenital sinus expand and incorporating the bottom of the ducts of Wolf and than the ureters; so the ureters come out directly into the urogenital sinus in two new orifices. Subsequent migration of the ureters and Wolf ducts product that the mesonephros trapped into Wolf ducts takes a triangular shape and it will be create trigone of bladder.
At the end of the third month the splanchnic mesoderm, lining the urogenital sinus, goes to build the muscles of the bladder and the allantois is going to close becoming the urachus.
ETIOPHATOGENETIC THEORIES ABOUT THE ORIGIN OF BLADDER EXTROPH
The embryogenesis of exstrophy-epispadias complex is a subject that has been a source of conjecture and controversy. It is also known that the human embryo does not pass through a stage of development that corresponds to exstrophy bladder. Hence, it is impossible from embryologic point of view to explain the bladder exstrophy as a result of simple developmental arrest. Numerous theories have been proposed to explain the etiopathogenesis of exstrophy bladder:
1 Hp states that the anterior rupture of the embryonic bladder is caused by the abnormal retention of fluid. However, this does not explain the commonly associated anomalies of genital and musculoskeletal systems.
2 Hp proposed that the abnormally large cloacal membrane would act as a wedge to the developing structure of the lower abdominal wall.But even if cloacal membrane is a normal embryologic structure in that area, and even if it is abnormally large, it should not act as a wedge. A cloacal membrane normally is an unstable structure lacking mesoderm, and it has a strong tendency to disintegrate. Hence, it can not have wedge effect.
3 Hp have suggested the anatomical basis of a common embryological origin for epispadias, bladder and cloacal exstrophy. It suggest that the first anomaly could be the lack of rotation in the pelvic ring primordia. It is a fact that the pelvic ring primordia doesn't rotate; however, it is the result of the higher origin of the genital tubercle. The event of the rotation of pelvic ring primordia occurs later in a chronological order (seventh week) than during the origin of genital tubercle (fourth week).
4 Hp is a new theory that propose that abnormal origin of the primordia of genital tubercle in a cephalad position than the normal will result in the wedge effect, and hence, it will interfere with the medial migration of the mesoderm as well as the midline approximation of mesodermal structures in the lower abdominal wall and prevent the lengthening of the body stalk, which is observed in newborn babies whose umbilical cord is inserted at the apex of the exstrophied bladder. This hypothesy is supported by the observation that in all cases of exstrophy, there is a normally pigmented skin bridge interposed in between the penile shaft (clitoris in female) and the scrotum (labia majora in female) dissociating these two structures.
Normal histology :Bladder layers are mucosa (urothelium, lamina propria, discontinuous muscularis mucosa), muscularis propria, adventitia, serosa/peritoneum at dome.
Urothelium:
● Formerly called transitional epithelium since intermediate between nonkeratinizing squamous and pseudostratified columnar epithelium
● 5-7 cell layers thick in contracted bladder, 2-3 cells thick in distended bladder; lines renal pelvis, ureters, bladder, most of urethra but not distal urethra
● Superficial urothelium (umbrella cell layer) is single layer of umbrella cells, which are large and elliptical with abundant eosinophilic cytoplasm and often binucleation or prominent nucleoli.
Lamina propria:
● Located between the mucosal basement membrane and the muscularis propria, is thinner at the trigone and bladder neck
● Contains loose to dense connective tissue, variably sized blood vessels that may be close to epithelium, lymphatics, variable adipose tissue
● Discontinuous muscular mucosa, usually associated with intermediate-sized arteries and veins; only 5% of bladders have well developed, continuous muscularis mucosa
● It is advisable to separate lamina propria invasion into above or beneath muscularis mucosae since the former is more likely to behave as a Ta tumor
Muscularis propria:
● Consists of inner longitudinal, circular and outer longitudinal layers of thick muscle bundles, may also contain adipose tissue between muscle fascicles, paraganglia
● Muscle layers are distinct only near bladder neck and in the remaining areas the longitudinal and circular layers mix freely without definite orientation.
● Muscularis propria may be greatly thickened if obstruction to urine flow develops
Von Brunn's nests (proliferative cystitis):
● Reactive proliferative change present in 85-95% of bladders; frequency increases with age; more common at the trigone
● Nests of cytologically benign urothelium in lamina propria; nests have regular spacing, extend to same horizontal level at base of proliferation
● May or may not have continuity with surface epithelium; inflammation is usually minimal; stromal reaction is absent
Histopathologic analisys in bladder extrophy
The pathologic findings of hematoxylin-eosin (HE) and Azan staining of the bladder showed highly increased collagen fibers in the submucosal layer and a decrease in the smooth muscle layer. The increase in collagen fibers in other organs causes loss of distensibility in the arteries or increased stiffness of the heart. Considering these facts, the pathologic findings in our patient suggest the compliance of the bladder was reduced. The decrease in the smooth muscle layer also indicated a decrease in detrusor contractility and compliance. Immunohistochemistry of the bladder showed a decrease in neuron cells, and the kit-positive interstitial cells in the submucosal layer indicated reduced conveyance of intrabladder stimulation to the spinal cord, leading to insensitivity of urinary storage. In addition, fewer neuron and kit-positive cells were found in the submucosal layer, indicating that the bladder sensation was insufficient and closer attention to frequent urethral catheterization would be required to preserve the upper urinary tract. Thus, the pathologic findings of the bladder contribute to speculation on future bladder function and to the management of the neuropathic bladder.
ENVIROMENTAL FACTORS
Environmental factors have an important role during the period of gastrulation , a process by which the bilaminar embryonic disc is converted to trilaminar embryonic disc.It is the beginning of morphogenesis and is significant event occurring during the third week. Gastrulation begins with the formation of primitive streak at about fifteenth day of embryonic life. The primitive streak is a midline proliferative region of the epiblast where the cells may break free from the epithelium and migrate beneath the epiblast to form the intra embryonic mesoderm. Gastrulation errors can be explained as errors in proliferation, migration and subsequent differentiation of the intra-embryonic mesoderm resulting in defective morphogenesis.
Environmental factors can again be classified into intrinsic and extrinsic. Intrinsic factors include the local environment around the developing embryonic disc (i.e.uterine endometrium and the cavities of the embryo). In first week of life, the blastomeres derive their nourishment, in part, from stores laid down in the cytoplasm of the primary oocyte and from tubal and uterine secretions. In second and third week of life, the embryonic disc is dependent on nutrients obtained from the fluid filled cavities of the amnion, the celom and the yolk sac. These fluids contain products arising
because of absorption by the trophoblast from the lysed uterine tissues and extravasated maternal blood. However, these sources of supply are much diminished and inadequate at an early stage in development. It therefore becomes imperative that some other source should be available at an early stage. This involves formation of placenta and establishment of fetal circulation. By the end of the third week, the primitive cardiovascular system is established and the heart begins to beat so that the blood now circulates. Thus, the third week of fetal life is a challenging period, when a transition of source of nutritional supply to the developing embryo is taking place. During the
third week, the existing nutritional supply starts diminishing and the fetal circulation is yet to start. Incidentally, it is the same period when gastrulation process is going on. The diminishing supply of nutrients is bound to affect the deeper tissues (mesoderm) more than the layers towards the fluid filled cavities (the ectoderm and the endoderm) and hence the vulnerability of the mesoderm. Support to this hypothesis comes from the fact that increase in the incidence of multiple congenital
malformations is recognized in the children of diabetic mothers. It is known that diabetes causes tissue starvation and hence the uterine endometrium is unable to provide optimal nutritional support.
Although often discussed as a cause the extent to which the extrinsic factors e.g. alcohol, smoking, medication, toxins can affect the embryo at this stage is also a matter of investigation, because extrinsic environmental factors come into play only after placentation and the establishment of fetal circulation resulting in intimate contact of the embryo with the maternal blood.
TEMPORAL-SPATIAL PROTEIN EXPRESSION IN BLADDER TISSUE
Identifying developmental proteins could lead to markers of bladder progenitor cells, which could be used to investigate bladder diseases. Understanding normal bladder development is of the utmost importance for developing strategies to treat congenital and acquired conditions that affect the bladder. Differentiation of the epithelium and mesenchyma into mature urothelium and smooth muscle appear to occur in an orderly sequence and in a specific pattern.
Embryologically the bladder forms from the urogenital sinus, which is an extension of the hindgut, which is an endodermal derivative. Based on the fact that the 2 structures arise from the urogenital sinus, which is an endodermal derivative, colud be study the temporal-spatial protein expression that induced the differentiation of signalling necessary for the presence of bladder structure. These different proteins are turned on and off during endodermal maturation until a certain stem cell exists that forms into urothelium and, if surrounded by the proper microenvironment, ultimately into an organized bladder.
Bladder urothelium has the capability to differentiate into different cell types, as evidenced by squamous metaplasia or cystitis glandularis. This suggests that stem cells exist in the urothelium and signals from the local tissue environment dictate their ultimate fate in organogenesis.
Between the factors that characterize the bladder progenitors cells there is Foxa2 , which is highly expressed in these cells, and after the bladder epithelium matures it is no longer expressed. It is supported by an indirect relationship between urothelial maturation (uroplakin positivity) and decreased Foxa2 expression.
For the smooth muscle differentiation has an important role Shh , a paracrine signal from urothelium to the surrounding mesenchyma. High levels of Patched , the receptor for Shh, are present in the mesenchyma surrounding the urothelium and decreased Patched expression is seen at the bladder periphery. Therefore, smooth muscle is inhibited at high concentrations of Shh and induced at low concentrations. Furthermore, Shh mutants have severe anorectal malformations, including hypoplasia of the bladder lumen and wall.
IMPORTANT ROLE OF p63
p63 is a p53 homologue required for cutaneous development that is expressed in immature squamous epithelium and reserve cells of the cervix.
The strong rationale for studying p63 as a candidate gene for human BEEC is based on its coordinating function during anogenital modeling and epithelial cell differentiation in the developing female mouse urogenital tract.
In the absence of p63, the ventral urothelium is neither committed nor differentiated, while the dorsal urothelium is both committed and differentiated. It has been proposed that p63 is required for the maintenance of 'stemness' of all stratified epithelia, or required for the very fundamental steps of commitment of and differentiation processes in stratified epithelia. The p63 (KET/p40/p51/p73L) gene encodes at least eight protein isoforms realized by alternative splicing and alternative initiation of transcription , alternate promoter usage results either in the presence (TA) or absence (ΔN) of a
classical transactivation domain.
By using antibodies, discriminating between only TA and ΔN forms, it has been established that ΔNp63 is the predominant isoform expressed throughout the bladder with a preferential expression in the ventral bladder urothelium during early development. It has also been shown that ΔNp63 is required for ventral specification in zebrafish. Loss of ΔNp63 results in reduction of ventral (non-neural) ectoderm, while ΔNp63 overexpression expands the ventral ectoderm.
To obtain a comprehensive overview of the transcriptional activity of p63 during the development of the urogenital system and external genitalia, Ching et al ( p63 (TP73L) a key player in embryonic urogential development with significant dysregulation in human bladder exstrophy tissue; 2010 ) performed whole mount in situ hybridization (WISH) on mouse embryos at gestational days 9.5-12.5 with particular emphasis on the region of the cloaca and the genital tubercle
These analysis of the p63 expression pattern in midgestation phase mouse embryos clearly showed the spatiotemporal correlation of p63 transcriptional activity with the critical phase of urogenital development.
Loss of p63 in mice was shown to cause limb and craniofacial defects, multiple malformations in urogenital development, and defects in the formation of the abdominal wall, resulting in exstrophy of the bladder. As causes for these pleiotropic defects, failures in epithelial to mesenchymal signalling as well as an antiapoptotic role of p63 were described. p63 expression in the cloacal and uretral epithelium suggests that p63 is necessary for proper function as a source of patterning or proliferation signals on the mesenchyme of the adjacent lateral plate and
genital tubercle mesoderm. The loss of p63 activity in this tissue can thus lead to the observed evelopmental defects that are a prerequisite for bladder exstrophies. ΔNp63 is required for epithelial development and formation of stratified epithelia, the lack of all or some of these isoforms might be involved in the formation of urogenital system malformations. ΔNp63 protein induces expression of the extracellular matrix component Fras1, required for maintaining the integrity of the epidermaldermal interface at the basement membrane. Mutations in human FRAS1 have been causally linked to classical Fraser syndrome, an autosomal-recessive defect, also known as Cryptophthalmos-Syndactyly syndrome. CFS shows phenotypic overlap with BEEC in that umbilical hernia (omphalocele), microphallus in males along with cryptorchidism, vaginal atresia or bicornuate uterus in females as well as diastasis of symphysis pubis in both genders are frequently observed.
MAIN GENES INVOLVED IN BLADDER EXSTROPHY
Many studies have been conducted to identify the genes involved in BEEC ( Genome-wide expression profiling of urinary bladder implicates desmosomal and cytoskeletal dysregulation in the bladder exstrophy-epispadias complex; 2011 ). The studies discovere that the two most down-regulated genes in BEEC, desmin and desmuslin are involved in desmosome mediated cell-cell adhesion and cytoskeletal architecture. Intriguingly, the sixth most overexpressed gene was desmoplakin, the most abundant desmosomal protein. Further findings indicate that p63, PERP, SYNPO2 and the Wnt pathway may also contribute to BEEC etiology. The desmosome, a rivet-like cellular junction structure, is primarily located in epithelial and muscle cells and is specialized for cell-cell adhesion. In addition to maintaining the structural integrity of tissues by resisting shear forces, desmosomes are critical for the formation of organs and tissues during embryogenesis. The molecular blueprint of the functional desmosome varies between tissues, but
generally consists of 3 principal components including desmosomal cadherins (desmocollins and desmogleins), armadillo type of junctional proteins (plakophilins and placoglobin), and plakin proteins (desmoplakin, plectin, envoplakin and periplakin). Plakin proteins serve as an anchor of the IF. As an integral part of the cytoskeleton IF confer resistance to physical stress by distributing mechanical forces throughout a tissue and participate in the formation of supracellular scaffolding that maintains the integrity of tissues. In addition to these classical mechanical functions of the desmosome, there is evidence that mechanical forces transmitted along the length of the IF to the nucleus regulate gene expression.
Keratin proteins constitute a major component of the IF in all epithelia and 3 type I cytokeratin genes, KRT10, KRT18 and KRT19, were found to be up-regulated in the EB. Even more intriguing was that the 2 most down-regulated genes in EB, DES and DMN encode muscle-specific IF proteins that directly interact with the C-terminal domain of desmoplakin, encoded by DSP, the sixth most overexpressed gene in EB samples. Evaluation of DES in the MAMEP database reveals that it is expressed in the differentiating somites of the trunk, the cloacal membrane and the ureteric cord, in accordance to its function in muscle development. These findings indicate that abnormal formation and/or anchoring of the IF to the desmoplakin component of the desmosome may be the specific cellular defect in BEEC.
Another gene observed is PERP, a tetraspan protein that is a direct p63 downstream target. The studies show that it is overexpressed in human bladder extrophy. Intriguingly, PERP, specifically localizes to the desmosomes where it extends through the plasma membrane to link neighboring cells.
Another highly up-regulated gene was WNT5A. WNT5A is strongly expressed in the paraxial and lateral mesoderm in the caudal end of the embryo, and is essential in the caudal extension of the body axis as well as the formation of the external genitalia. The expression of WNT5A is induced by Gli2. Interestingly, p63 expression in the cloacal endoderm is also up-regulated by Gli2, suggesting that both WNT5A and p63 are regulated by a common upstream pathway. Further support for a causal interplay of WNT5A in the expression of BEEC, arises from the physical overlap of the RRM2 gene with a region of suggestive linkare because it is up-regulated in EB tissues, and it functions downstream of ß-catenin as an inhibitor of Wnt signalling.


text:
Ole Bischof, né le , est un judoka allemand évoluant dans la catégorie des moins de  (poids mi-moyens). Il compte à son palmarès un titre de champion olympique ainsi qu'un titre de champion d'Europe.

Biographie

Champion d'Allemagne chez les juniors en 1997, Ole Bischof le devient en senior en 2001 à Hamm. En 2003 et 2004, il monte sur de premiers podiums lors de tournois de coupe du monde à Hambourg ou Budapest. En 2004, il remporte une première récompense au niveau international à l'occasion des championnats d'Europe disputés à Bucarest. Le judoka allemand n'y échoue qu'en finale contre Ilias Iliadis, futur champion olympique de la catégorie de poids. Mais malgré ce podium, Ole Bischof n'est pas sélectionné pour participer aux Jeux olympiques d'été de 2004, son compatriote Florian Wanner, champion du monde en titre, lui étant préféré. À la suite de la retraite sportive de ce dernier, Bischof devient le titulaire allemand dans la catégorie des moins de . L'année suivante, il décroche son premier titre de champion d'Europe à Rotterdam mais n'est pas performant lors des championnats du monde 2005 organisés au Caire. En 2006, l'Allemand perd son titre continental. Début 2007, il signe deux podiums aux tournois de Paris et de Hambourg avant de terminer au pied du podium lors de l'Euro, comme l'année précédente. Qualifié pour les Jeux olympiques d'été de 2008 en grande partie grâce à sa victoire au tournoi de Rotterdam en , Ole Bischof devient champion olympique lors du rendez-vous de Pékin. Il réalise en effet un parcours sans-faute en éliminant notamment le champion du monde en titre Tiago Camilo, le vice-champion olympique en titre Roman Gontyuk et le Sud-coréen Kim Jae-Bum battu en finale par un yuko.
En 2012 Ole, Bischof finit vice-champion olympique.Il est battu en finale par Jae-Bum Kim qu'il avait battu à la précédente olympiade

Palmarès

Jeux olympiques

 Jeux olympiques de 2008 à Pékin (Chine) :
  Médaille d'or dans la catégorie des moins de  (poids mi-moyens).
judo aux Jeux olympiques d'été de 2012
médaille d'argent dans la catégorie des moins de  (poids mi-moyen).

Championnats d'Europe

Divers

 Principaux tournois :
 1 podium au Tournoi de Paris ( en 2007).
 2 podiums au Tournoi de Hambourg ( en 2003 et 2007).
 1 podium au Tournoi de Rotterdam ( en 2007).
 2 podiums au Tournoi de Moscou ( en 2006 et 2007).

 National :
 4 podiums aux championnats d'Allemagne ( en 2001,  en 2002,  en 2003,  en 2004).

Liens externes

Navigation

Judoka allemand
Judoka aux Jeux olympiques d'été de 2008
Judoka aux Jeux olympiques d'été de 2012
Champion olympique allemand
Champion olympique de judo
Naissance en août 1979
Naissance à Reutlingen
Médaillé d'argent olympique allemand
Champion d'Europe de judo

redpajama_set_name: RedPajamaWikipedia


Mobile technology has become an integral component in our lives and is driving the expectations of how we interact with our business systems. Like SAP, top businesses today recognize the value of enabling their employees to work anytime, anywhere through the use of mobile technologies. However, providing this ability in an enterprise context can become quite tricky. We certainly want to be able to do business on our phones and tablets, but we're not necessarily aware of what needs to go on behind the scenes to enable this. In this course, we'll learn what it takes to make an enterprise-ready app with SAP mobile solutions.


Spring Events and Festivals | Feather Sound News & Beyond! Spring Events and Festivals – Feather Sound News & Beyond!
Spring's arrival in St. Pete/Clearwater brings milder temperatures along with a diverse lineup of events, from high-speed to low-key. There are art festivals, cultural celebrations, sporting events and a sprinkling of major festivals devoted to art, music and food. Here's a look at just some of the most anticipated annual happenings in St. Pete/Clearwater in Spring.
You won't be surprised to learn that St. Pete/Clearwater – with all of its artsy, waterfront allure – hosts one of the nation's most magnetic art festivals. Mainsail Arts Festival, held annually over two days in April, routinely draws 100,000 attendees to downtown St. Pete's Vinoy Park, where 200-plus visual artists and craftspeople display their work against sparkling Tampa Bay. Better yet: Admission to the festival is FREE.


Not long ago someone asked me how I find names for my characters.
The answer is, I search the Deaths columns! And Nesci, the name I gave Laura, the main character in Things We Cannot See, was no exception. But this one came with an unexpected twist.
It happened two months ago while holidaying in beautiful Italy with Australian friends of Italian heritage who mentioned their friends named Nesci, also Italians now living in Australia. How serendipitous is that? I'd chosen the name because I thought it was uncommon. 'Did someone in your friend's family die in Australia about two years ago?' I asked.
It turns out their friend's brother had passed away at the time I was searching for Laura's surname. It was his name I had zoomed in on and taken for my book!
We now have a new friend named Nesci. And I have been assured the man whose name I borrowed would not have minded a bit. Indeed, his cousin, also named Nesci, wants to help me write my next story!
Things We Cannot See, will be released by HarperCollins Impulse 1st January 2017, and is available at Amazon, Kobo, iTunes, HarperCollins and all good eBook stores.
Looking forward to reading this new release.
Hope u sell a Million Copies !!


text:
Q: Check if a tkinter widget is visible I need to be able to check if a tkinter widget is visible (if its pack or grid method has been called).
I'm currently doing the following:
def is_visible(widget):
    try:
        widget.pack_info()
    except tk.TclError:
        # pack_info raises if pack hasn't been
        # called yet.
        return bool(widget.grid_info())
        # grid_info returns {} if grid hasn't been
        # called yet.
    else:
        return True

Is there any way in which I could improve this code, by using a standard widget attribute, or through some other solution that's less 'hacky'?

A: You can try widget.winfo_ismapped() instead :

Check if the window has been created. This method checks if Tkinter
  has created a window corresponding to the widget in the underlying
  window system (an X window, a Windows HWND, etc).
Returns:
      A true value if a window has been created.

redpajama_set_name: RedPajamaStackExchange


text:
NHL All-Star game: Chara"s goal wins it for…
NHL All-Star game: Chara"s goal wins it for his namesake
PUBLISHED: January 30, 2012 at 12:00 a.m. | UPDATED: September 11, 2018 at 12:00 a.m.
OTTAWA — Marian Gaborik got the best of New York Rangers teammate Henrik Lundqvist, and Zdeno Chara scored the winning goal for the NHL All-Star team named after him.
Even in defeat, Daniel Alfredsson rewarded the hometown fans with two goals and an assist, and then the Ottawa Senators captain provided a hint that he might come back for one more season.
For an All-Star game that lacked the league"s top-name talent in Sidney Crosby and Alex Ovechkin, there was plenty to keep everyone buzzing on Sunday.
Gaborik scored three times, added an assist and earned MVP honors, and Team Chara used a third-period offensive eruption to secure a 12-9 win over Team Alfredsson.
"We have a lot of fun out there," said Lundqvist, who allowed three goals on 12 shots in the first period. "A lot of times you might forget because it"s a lot of pressure, and you put a lot of pressure on yourself, but this weekend is all about the game of hockey and having fun with it. So we"ve been enjoying ourselves, and I hope the fans felt the same way."
What was not to like?
Fans were treated to a wide-open, no-hitting style in a game that featured plenty of nifty passing plays, numerous odd-man breaks and even a penalty shot awarded to Steven Stamkos, who leads the NHL with 32 goals.
Stamkos, however, was foiled on his freebie — the second in All-Star game history — when he attempted the same spin-around move he used to beat Carey Price in the skills competition on Saturday night. Jimmy Howard didn"t bite on Sunday, holding his ground and hugging the post to stop Stamkos" penalty-shot attempt.
"I think I ran out of moves," Stamkos said. "I tried something fancy and hoped it would work. It didn"t. But I just tried to have fun with it."
Gaborik enjoyed himself the most, earning bragging rights over Lundqvist after the two spent the past few days playfully going back and forth on Twitter. The mock feud was over Lundqvist — Alfredsson"s assistant captain — choosing not to select Gaborik in the All-Star player draft on Thursday.
Gaborik showed just how motivated he was. After opening the scoring 4:34 in on a give-and-go with Pavel Datsyuk, Gaborik circled the net dropped to one knee and pointed his stick machine-gun style at Lundqvist while pumping his fist.
The move was identical to one done by Rangers forward Artem Anisimov earlier this season when he scored against the Tampa Bay Lightning.
This one was all in fun, said Gaborik, the 16th player to score at least three goals — one short of matching the record — in the All-Star game. It was the first All-Star hat trick since Rick Nash had three goals in 2008. "It"s always tough to score on him," Gaborik said of Lundqvist. "It"s not easy. I was fortunate to be lucky against him, but I think he"s one of the best if not the best goalie in the league."
Tim Thomas made 18 saves in the final period, and extended his record by winning his fourth All-Star game.
Hossa and Jarome Iginla had a goal and two assists, and Joffrey Lupul scored twice for Team Chara.
For Team Alfredsson, Henrik Sedin had a goal and two assists, and Daniel Sedin, John Tavares, Jason Pominville and Milan Michalek had a goal and assist each.
The outcome was decided in the final period when Team Chara outscored Team Alfredsson 6-3.
With the game tied at 8, Chara, Marian Hossa and Corey Perry scored in a span of 1:22, beating goalie Brian Elliott on consecutive shots.
Gaborik set up Chara for the decisive goal, flipping the puck into the high slot, where Chara slapped it in.
"I was surprised that I was open, and I just put it on net," Chara said. "It"s nice to get the win. The fans saw some goals, and then as we were going toward the end, you could see that the guys wanted to win." Chara paid respect to Alfredsson, saying he was rooting for his former Senators teammate to complete his hat trick.
"Alfie"s such a classy guy, obviously a big icon in Ottawa and Sweden, as well, and such a great player to represent this team," Chara said. "So of course I was pulling for him."
After falling behind 3-0, Team Alfredsson rallied to tie it before the first period ended. But they didn"t get their first — and only lead — until Alfredsson scored twice during a 1:31 span to put his team up 6-5 with just under four minutes left in the second.
His first goal came on a great individual effort in which Alfredsson, dragging the puck behind him, split defensemen Kimmo Timonen and Ryan Suter, and flipped a shot that sneaked inside the right post to beat Price. Alfredsson"s second came on a wonderful passing play courtesy of Daniel and Henrik Sedin, whom Alfredsson was looking forward to play with when he drafted the twins.
That got the crowd chanting "Alfie! Alfie! Alfie!"
He nearly scored his third goal in the third period, only to have a one-timer from the left circle ring off the post.
But it was after the game when Alfredsson sounded upbeat about his future in an interview broadcast on the arena"s scoreboard.
With a smile on his face, and fans cheering his name, Alfredsson said: "Fifty percent yes, and my wife"s going to have to decide the other 50."
He has one year left on his contract.
It a game built around offense, the goalies still found ways to have fun with it.
Price allowed three goals on 14 shots, and lamented during the first intermission the lack of defense.
"I feel like being a lamb getting led to slaughter," Price said. "I"m must be holding on for the ride today and hope I don"t get lit up too bad."
Chara 12, Alfredsson 9

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Girlie fit. Neoteric™ textured fabric with inherent wickability. UPF 30+ UV protection. Racer back style. Self fabric bound neck and armholes. Twin needle curved back hem. Printed/tear out neck label (some colours in transition). WRAP Certified Production.


I was on the road for most of the week on business commitments as I also continued on-going support for the Daily Outsider helping with curating the Twitter Channel as I was also blown away by the continued beauty of Southern California. I captured these images when visiting Mission Viejo Library and as I was on the road in Aliso Viejo.
It has been quite a week around our World as President Trump has been quite busy yet again slamming the Justice Department and the Justice System and as a Tax Bill that it appears would in fact stymie Economic Growth was introduced. This is not me noting this--but Mark Zandi who served as the Chief Economic Advisor to John McCain during his Presidency. Ozy had a column about how the Tax Plan was about to Annoy "coastal elites"--which I took issue with simply because the plan itself will steal from us in California to help the so-called Red States (terms I personally despise).
"It begs the question, where are members of the administration getting their information from? They're obviously not getting it from their own scientists."
PHILIP B. DUFFY, president of the Woods Hole Research Center, on the release of a report from 13 federal agencies that says humans are the main cause of global warming, a stance contradicting much of the Trump administration's position.
As this occurred, The President gave another interview to Fox News and basically threw the entire Department of State under the bus as he has said he will not fill top State Department positions by noting this, "I am the one that matters". I found the reporting on President Trump wanting to talk on the phone with Hassan Rouhani to be especially amusing because to me it was simply this: Obama talked with Rouhani--so then Trump had to do it too especially as Trump has been so busy simply destroying whatever Obama Built. This is as I also picked up the Hariri resignation in Lebanon. I shared observations on it in my WordPress corner as I saw Eli Fares' column on it--he's as good as it gets writing about the realities in Lebanon.


The only currency that we all have the same amount of is time. Time is the ultimate currency and how you invest your time will determine your success. In order for you to attain your WHY in life, you need to realize that every minute wasted is currency/money you just lost. Every successful person that you see in life is simply someone who understands the power of waiting through the seasons of harvest time.
"While the earth remaineth, seedtime and harvest, and cold and heat, and summer and winter, and day and night shall not cease." "And let us not be weary in well doing; for in due season, we shall reap, if we faint not." These two citations express the importance of waiting and being persistent. When you are investing your currency/time correctly, you will reap the rewards.
The following is a very inspirational message that I know you will need on your journey to achieving your WHY in life!
Rest if you must – but never quit.
If you quit today, you'll never know what lies just around the bend. Motivating champions worldwide!


Peruvian Reverse Painted Glass Wall Mirror, "Turquoise Chorus"
All is peace and beauty in this delicate scene, as Gelacio Girón depicts songbirds and flowers. Capturing the scene on reverse painted glass, he creates a beautiful wall mirror. Gilt enhances this original design.
You can find reverse painted glass mirror 'Turquoise Chorus' by Gelacio Giron in wall decor categories such as Animal Themed Mirrors, Reverse Painted Glass Mirrors, Glass Mirrors and Wood Mirrors. Enjoy exploring these sections for other Novica treasures.


The LHJ participants contemplating on the activity given to them.
"What am I happy about today?" was the opening question asked to the 22 participants of the Life's Healing Journey (LHJ) Retreat that took place on February 23–24, 2019. This event was made possible through the initiative of our Spirituality of the Heart Desk. MSC brothers, parish lay leaders, and workers of Sta. Quiteria and its Mission Groups joined the retreat. CFA President Fr. Filoteo Pelingon, MSC welcomed the participants and told them that they should experience the retreat from the heart, not from the head. Meanwhile, Fr. Edwin Borlasa, MSC talked about the history of the MSC, the LHJ and its ministry, and its connection to the spirituality of the heart. It was a two – day event intended for the participants to meditate, listen to various speakers, and participate in exercises that allowed them to address their hurts and pains. They also shared their own experiences and applied what they have learned in the talks. Fr. Edwin said that one participant told him that he taught he knew himself well, but didn't realize that there were things about him that he only discovered in the said retreat. The retreat will also be echoed in the attendees own parishes. Hence, they tried to everything that happened in the retreat sessions.
Healing doesn't happen overnight. One Life's Healing Journey isn't enough. It is a continuous process, a decision to recognize your pains and baggage, and surrendering everything to God. Do you have any excess baggage? Let go, and allow yourself to be healed. Life's Healing Journey Retreat could help you. The second leg of the retreat will happen this coming April 2019.


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Donald Trump's 5 reasons to fire Rod Rosenstein reveal true aim: Obstructing Robert Mueller
Donald Trump has floated 5 reasons to fire Rod Rosenstein and all fall apart under scrutiny. His true aim is clear: obstructing Robert Mueller's Russia investigation.
Norman Eisen and Richard Painter
Opinion contributors
President Trump reportedly is considering firing Rod Rosenstein, the deputy attorney general who appointed special counsel Robert Mueller and supervises his investigation into Russian interference in the 2016 election. To prepare the way, Trump has by our count floated five rationales internally and externally for doing so. The briefest scrutiny of these purported justifications shows that they are baseless, and makes apparent the president's true motivation: to obstruct the investigation that Rosenstein oversees.
Trump has reportedly complained about Rosenstein being a Democrat and coming from heavily Democratic Baltimore. In fact, Rosenstein is a decades-long registered Republican who worked as a federal prosecutor in Baltimore. That was part of a long career at the Justice Department devoted to the rule of law under both Republican and Democratic presidents. He was selected from a pool of Republican lawyers and nominated by Trump for his position as deputy attorney general.
More:Stormy Daniels is just one reason Trump couldn't work in his own White House
More:Robert Mueller terrifies President Trump. Of course he wants him gone.
Trump has also suggested that Rosenstein acted improperly when he reauthorized the Justice Department's application for a Foreign Intelligence Surveillance Act court warrant to monitor onetime Trump campaign adviser Carter Page. Rep. Devin Nunes, R-Calif., attempted to paint this application as improper in his infamous memo on the topic.
But closer examination led most observers to conclude that the Justice Department had followed appropriate procedures. In any event, the warrant was first authorized long before Rosenstein arrived; he signed off on a much later application for reauthorization, in which the department successfully demonstrated to a judge that the warrant had already provided valuable information.
Additionally, Rosenstein has apparently drawn Trump's ire by approving search warrants against Michael Cohen, Trump's personal attorney. As one of us has written, these warrants result from an investigation of very serious allegations of criminal conduct, including possible illegal campaign contributions by Cohen. Because they target an attorney, these warrants underwent heavy review within the Justice Department, and like all warrants they were approved by a federal judge. The notion that Rosenstein acted improperly is unfounded.
Next, Trump is apparently suggesting that Rosenstein is close to former FBI director James Comey — and has appointed the special counsel and taken other steps to get revenge for his firing. This theory is as flimsy as the rest: While the two worked together, they are not friends. It is also inconsistent with other evidence, including Rosenstein's extremely harsh assessment of Comey's work (on the Hillary Clinton email case) in a memorandum he wrote before Comey's firing.
It is that memorandum that leads to the final main line of attack on Rosenstein. The president reportedly believes that Rosenstein has a conflict of interest because he wrote that memorandum and because Mueller is investigating the circumstances surrounding Comey's firing. That would make him a witness, this argument goes, and so render him conflicted in supervising Mueller.
More:Donald Trump ethics waivers flood the swamp with conflicts of interest
POLICING THE USA: A look at race, justice, media
This sally rests on a profound misunderstanding of the law of conflicts. Being a fact witness does not require a Justice Department employee to stop working on a matter immediately. None of the relevant conflicts rules requires a supervising official who is a fact witness to step away from an investigation (if there is no business or personal interest in the outcome of a case). Even if Rosenstein is a fact witness, the issue of recusal arises only when and if he is going to testify at trial.
The American Bar Association's Model Rules of Professional Conduct state that a lawyer should not act as an advocate at a trial where the lawyer will also be a necessary witness. The ABA rules also state explicitly that a lawyer from one firm is not disqualified if another lawyer from the same firm is a witness.
The purpose of these rules is to ensure that a court or a jury is not "confused or misled by a lawyer serving as both advocate and witness." It stretches this principle beyond the bounds of reason to suggest that this means a Justice Department lawyer cannot supervise the investigation of a case if there is even a possibility he could be a witness. If such a standard were applied in the private sector, just about every corporate general counsel would be required to resign at the outset of any investigation in which he or she could be called as a witness. That is nonsensical.
Everything we know about Rosenstein's handling of the special counsel's investigation suggests that he has acted with integrity. He has clearly defined Mueller's jurisdiction. When a matter that appeared to be unrelated to that jurisdiction appeared, he referred it to the appropriate U.S. Attorney's office rather than expanding the special counsel's scope. Far from giving Mueller sprawling Ken Starr-like power to go after whatever potential offenses he comes across, Rosenstein has kept the special counsel focused on Russian interference, potential cooperation between Russia and the Trump campaign, and offenses such as obstruction of justice and financial crimes arising directly from that investigation.
Under these circumstances, if Trump fires Rosenstein, it will clearly be for one reason and one reason alone: to impede the lawful investigation of the president and those close to him. Similar actions by President Nixon in the Saturday Night Massacre led to his downfall. The firing of Rosenstein would have the same outcome for Trump.
Norman Eisen, chair of Citizens for Responsibility and Ethics in Washington, and Richard Painter, a law professor at the University of Minnesota, were chief White House ethics counsels for the Obama and Bush administrations, respectively. Follow them on Twitter: @NormEisen and @RWPUSA


Very often improvement is seen by the second visit though it may be partial or slight. Prognosis varies and depends on the condition, how long the patient has had it for and how it has been managed up to then.
Generally speaking by the 3rd month of treatment most patients should see considerable improvement in their condition if they have taken the herbal medicines as prescribed and have followed any dietary or lifestyle advice given. This is a guideline and may not apply to every case.
The rule of thumb is 'a condition may take a month for every year of duration plus 1-2 extra for good measure'. This means a 10-year condition may take a year to clear (10 months +2). However we humans are very complex and will invariably present with more than one condition. It is common for some conditions to clear more easily and quickly while others may take longer. It is always very rewarding to see patients responding well and quickly when starting herbal treating.
Digestive and skin conditions usually respond very quickly while others such as hormonal or immunological may take longer for changes to be monitored. Follow up visits will again depend on the severity of the condition and will vary from 2-3 weeks initially until a positive response is obtained and after that they usually take place every 4-6 weeks depending on progress.
The patient is given enough herbal medicine to last until the next visit and if necessary, extra medicine can be left for collection or posted if visit time is extended.
Promoting energy and enhancing well being.
Immune system deficiencies which can lead to recurrent infections, allergies and some auto-immune conditions.
Digestive problems, elimination and absorption difficulties.
Hormonal imbalances and fertility difficulties in men and women as well as problems during pregnancy or the menopause.
Emotional and stress related conditions.
Joint problems, arthritic conditions, osteoporosis.
Skin conditions in children, adolescents and adults.
Hair loss or hair growth problems.
Babies and children's illnesses ranging from recurrent infections, catarrhal states, breathing difficulties, skin conditions, allergies and poor digestion.


text:
LCMS mission society files First Amendment lawsuit
The Apple of His Eye, a St. Louis-based LCMS mission society, and two of its missionaries filed a lawsuit May 1 in the U.S. District Court for the Eastern District of Missouri seeking an injunction against the City of St. Louis for violation of their First Amendment rights to proclaim the Gospel in public places.
In its mission to "bring the message of Jesus the Messiah to Jewish people and gentiles alike — and to equip the church to do the same," the Apple of His Eye regularly sponsors outreach events in public places, such as parks, where its staff and volunteers distribute religious literature and engage passersby in conversation about Christianity.
In 2006, Apple of His Eye founder Steve Cohen and senior missionary Alan Butterworth were distributing Christian tracts during a "gay pride" festival in Tower Grove Park in St. Louis when they were threatened with arrest by park officials unless they stopped handing out their materials, according to a news release from the mission society.
After Cohen and Butterworth removed their literature from the park, they returned to share personal testimonies with people visiting the park. Officials again threatened to arrest Cohen and Butterworth if they did not leave the premises, the news release reports. The two left, even though they believe that religious speech, through the distribution of literature and expressions of religious views, is fully protected by the First Amendment.
The lawsuit was filed after the mission society made several unsuccessful attempts to resolve the matter with the city. The suit is being handled by the American Liberties Institute of Orlando, Fla.
Parties in the lawsuit were unable to talk to Reporter until after the court renders its decision.
For more information about The Apple of His Eye, visit its Web site at www.appleofhiseye.org or call (636) 326-4040.
LWR seeks Thrivent members to build homes in India
Requests for Reinstatement (June)


Marshall Mission, special mission undertaken in late 1945 by U.S. general George C. Marshall to negotiate a settlement of the Chinese civil war (1945–49), fought between the Nationalist and the communist forces. Though Marshall stayed in China for more than a year, his mission ended in failure.
Marshall's dispatch to China by U.S. president Harry S. Truman in December 1945 came at a time when U.S.-sponsored negotiations between Chiang Kai-shek, the Nationalist president of China, and Mao Zedong, the leader of the communists, had broken down, and civil war seemed imminent. The appointment of the distinguished World War II chief of staff Marshall as a special presidential ambassador forced the two enemies to enter into serious negotiations once again. By Jan. 10, 1946, both sides had agreed to an immediate cease-fire and the convocation of a Political Consultative Conference that would negotiate the eventual composition of the coalition government, through which both sides could jointly rule China. On February 25 a proposal was concluded for the joint reduction of the two armies, based on a 5 to 1 ratio of Nationalist troops to communists.
By spring, however, the truce between the two sides had collapsed. Fighting began first in northeastern China (Manchuria)—a region that contained China's major industrial base by the end of the Japanese occupation of it in 1945—as Soviet troops, who in the course of accepting the Japanese surrender had temporarily occupied Manchuria, evacuated and plundered the area. Marshall was recalled from China in January 1947.


Sarah Dunant, the internationally acclaimed author of The Birth of Venus, joins us to celebrate In the Name of the Family.
Dunant's new novel is a brutal, stunning account of young Machiavelli's encounter with the notorious Borgia family. A follow-up to the acclaimed Blood & Beauty, In the Name of the Family is a fresh and vital experience for any reader with an interest in the Renaissance period or, of course, Machiavelli himself. Rediscover the incredible cast of characters that shaped an era, not least the astonishing Lucrezia Borgia. The infamous daughter of the Borgia Pope and sister to a brutal military leader, Lucrezia is known as little more than a dynastic pawn and fallen woman; Dunant's history sheds light on her little known roles as a diplomat and patron of the arts, and brings her to life as a woman.
"A wonderful novel – taking you deep into the world of Renaissance passion and Renaissance papacy. Part of me was happily lost in the time travel, part of me repeatedly struck by how vividly ancient Rome met modern Rome, and how the city of history came to life." – Mary Beard on Blood & Beauty.
Thrillingly written and historically accurate, Dunant's masterclass of Renaissance fiction will capture your imagination and leave you breathless.


text:
[2017 Free Agency] Shinya Tsuruoka Rumors
November 25, 2017 at 10:28 pm by Gen
Categories: NPB
Tags: 2017 Free Agency, Rumor Mill, Softbank Hawks
Player Pages: Tsuruoka, Shinya
@ 3:58p Nippon Ham Tsuruoka agreed to a two-year deal worth an estimated thirty million yen plus incentives. Sponichi 12/18/2017, Nikkan Sports 12/18/2017
@ 3:32p Nippon Ham Tsuruoka met the Fighters for a second time in Sapporo on December 18. A press conference is scheduled for the same day. Sponichi 12/18/2017, Sanspo 12/18/2017
@ 1:29a Nippon Ham Tsuruoka met with the Fighters at a hotel in Sapporo on November 3. The Fighters showed strong interest by offering a multi-year deal. Tsuruoka was grateful for the meeting and is open to returning to his former team. Daily Sports 12/3/2017, Nikkan Sports 12/3/2017, Nikkan Sports 12/3/2017, Sponichi 12/3/2017
@ 2:59p Nippon Ham The Fighters announced that they are scheduled to meet Tsuruoka in Sapporo on November 3. They see as someone that can still contribute at Ichi-gun. Sanspo 12/1/2017
@ 2:53 Nippon Ham The Fighters are planning to sit down with Tsuruoka within the next few days. They could reach an agreement before the end of the year. Daily Sports 11/30/2017, Daily Sports 11/30/2017
@ 10:28p — Tsuruoka told reporters on November 24 that he has been carrying his mobile phone around with him, but has not received any offers. He did receive a call from Softbank Hawks Chairman Sadaharu Oh. Oh told Tsuruoka he supported his decision to exercise his free agent option. Nikkan Sports 11/25/2017
[11/6/2017] Shinya Tsuruoka planning to exercise FA option
NPB Standings [Full]
Hiroshima 143 88 51 4
Hanshin 143 78 61 4
Yokohama 143 73 65 5
Yomiuri 143 72 68 3
Chunichi 143 59 79 5
Yakult 143 45 96 2
Softbank 143 94 49 0
Seibu 143 79 61 3
Rakuten 143 77 63 3
Orix 143 63 79 1
Nippon Ham 143 60 83 0
Lotte 143 54 87 2
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meganinja on [2/22/2019] Rakuten Eagles reach Ikusei agreement with Luis Jimenez
meganinja on Link Highlights for February 2019
meganinja on [1/26/2019] 91st Spring Koshien High Schools
mustardman on [1/15/2018] 2019 Hall of Fame Class: Tatsunami, Gondo, Wakimura
MoeyoCD on [12/21/2018] Ryosuke Kikuchi would like to be posted
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Ohtlik siis, kui kasutatakse mingit eriti odavat akulaadijat ja aku ise juba vilets, elektrolt lheb kiiresti keema ja pinge vib tusta ka le 16 voldi. Korras akul peaks 15V piiriks olema...tavaliselt vist mingi 14,8V. Normaalne laadija tabab selle ra, mingi hiina rmps laseb aga julgelt edasi kui igel ajal jaole ei saa. On varta (D 22) aku ja mingi veneaegne akulaadija, aku minuarust kuidagi lahti ei ki ja mingeid korke kuskil nha ei ole.
Abelmoschus esculentus Abelmoschus esculentus 'Clemson's Spineless' Abelmoschus esculentus 'Cow's Horn' Abelmoschus esculentus 'Feuerteufel' Abelmoschus esculentus 'Hill Country Red Okra' genus abelmoschus esculentus 'Mammoth Spineless' integrated genus abelmoschus esculentus 'Okra Red' organic dilleniid dicot genus esculentus 'Red vino Okra' Abelmoschus esculentus 'Red Spray' essential Abelmoschus esculentus 'Star of David' Abelmoschus esculentus 'Star of David' constitutional Abelmoschus esculentus f1 'Cajun Delight' Abelmoschus esculentus f1 'Pure Luck' Abelmoschus manihot (Hibiscus man.) Abelmoschus genus manihot 'Sunset Grandiflora' Abelmoschus moschatus genus abelmoschus moschatus 'Dwarf peaceable Mix' Abelmoschus moschatus 'Dwarf Pacific Orange-Red' Abies alba gymnosperm genus amabilis gymnosperm genus balsamea Abies balsamea 'Cook's downhearted Improved' Abies borisiiregis gymnosperm genus bracteata genus abies cephalonica Abies chensiensis Abies chinensis gymnosperm genus cilicica Abies concolor genus abies concolor 'Argentea' Abies concolor ssp lowiana gymnosperm genus delavayi genus abies densa Abies fabri gymnosperm genus fargesii Abies firma genus abies forrestii v smithii (Abies georgei) genus abies fraseri gymnosperm genus grandis Abies grandis coastwise strain gymnosperm genus holophylla gymnosperm genus homolepis Abies koreana gymnosperm genus lasiocarpa Abies lasiocarpa ssp arizonica genus abies magnifica Abies magnifica v shastensis Abies nephrolepis Abies nordmanniana gymnosperm genus nordmanniana prov. Salter's) Alstroemeria magenta Alstroemeria magnifica liliaceous plant magnifica ssp maxima liliaceous plant modesta Alstroemeria pallida Alstroemeria paupercula Alstroemeria pelegrina liliaceous plant philippii Alstroemeria polyphylla Alstroemeria presliana ssp australis liliaceous plant pseudospathulata liliaceous plant pulchra liliaceous plant pulchra ssp lavandulacea Alstroemeria recumbens liliaceous plant revoluta Alstroemeria sarco liliaceous plant schizanthoides Alstroemeria quality formula mix, with spp list Alstroemeria spectabilis Alstroemeria spp overlook mix liliaceous plant spp mix liliaceous plant timida liliaceous plant umbellata liliaceous plant vilcheana liliaceous plant werdermannii liliaceous plant zoellneri caryophylloid dicot genus denticulata caryophylloid dicot genus ficoidea 'Purple Knight' mallow cannabina hollyhock hirsuta mallow officinalis Althaea officinalis 'Alba' althea officinalis 'Erfurter' Alyogyne hakeifolia Alyogyne huegelii Alysicarpus rugosus Alyssoides graeca Alyssoides utriculata Alyssoides utriculata 'Tinkerbells' cruciferous plant 'Carpet of Snow' cruciferous plant 'Creamery' madwort 'Easter Bonnet profound Rose' Alyssum 'Easter cowl Lavender' Alyssum 'Easter protective cover Mixed' Alyssum 'Easter Bonnet Pink' cruciferous plant 'Easter Bonnet Violet' cruciferous plant 'Easter cowl White' Alyssum 'Nature down Rosy Red' crucifer 'New Apricot' Alyssum 'New Lemon' cruciferous plant 'New Mixed' ('Aphrodite Mixed') cruciferous plant 'New Purple' Alyssum 'New Red' Alyssum 'New Salmon' crucifer 'Pastel Carpet Mixed' Alyssum 'Rosie O'Day' Alyssum 'Royal Carpet' violet madwort 'Snow Crystals' Alyssum 'Snowcloth Improved' Alyssum 'Snowdrift' Alyssum 'Tiny Tim' genus alyssum 'Wonderland Deep Purple' Alyssum 'Wonderland in depth Rose' Alyssum 'Wonderland Lavender' genus alyssum 'Wonderland Mixed' cruciferous plant 'Wonderland Pastel Pink' crucifer 'Wonderland Purple' madwort 'Wonderland White' genus alyssum alpestre genus alyssum alpestre ssp serpyllifolium Alyssum argenteum cruciferous plant armenum Alyssum cuneifolium crucifer halimifolium dilleniid dicot genus macrocarpum madwort montanum crucifer montanum 'Luna' dilleniid dicot genus oschtenicum Alyssum ovirense Alyssum pulvinare Alyssum pyrenaicum Alyssum repens cruciferous plant scardicum Alyssum serpyllifolium Alyssum spinosum Alyssum stribryni madwort tortuosum genus alyssum wulfenianum Amaranthus albus genus amaranthus blitoides Amaranthus caudatus Amaranthus caudatus 'Candelabra' Amaranthus caudatus 'Pony Tails' Amaranthus caudatus 'Red Octopus' genus amaranthus caudatus 'Velvet Curtains' genus amaranthus caudatus 'Viridis' 'Green Cascade' caryophylloid dicot genus chlorostachys genus amaranthus cruentus genus amaranthus cruentus 'Alegria' Amaranthus cruentus 'Autumn's Touch' Amaranthus cruentus 'Bronze Standard' caryophylloid dicot genus cruentus 'Foxtail' Amaranthus cruentus 'Hot Biscuits' caryophylloid dicot genus cruentus 'Mayo Grain' genus amaranthus cruentus 'Mexican Grain' Amaranthus cruentus 'Oeschberg' Amaranthus cruentus 'Paiute' Amaranthus cruentus 'Red church building Superior' Amaranthus cruentus 'Red Cathedral' Amaranthus cruentus 'Southern Tepehuan Baute' Amaranthus cruentus 'Split Personality' Amaranthus cruentus 'Towers Green' caryophylloid dicot genus cruentus 'Towers Red' genus amaranthus cruentus x 'Hopi Red Dye Amaranth' caryophylloid dicot genus dubius (bayam bhaji) caryophylloid dicot genus graecizans Amaranthus grain, crop for preparation use Amaranthus hybridus Amaranthus hypochondriacus Amaranthus hypochondriacus 'Erythrostachys' Amaranthus hypochondriacus 'Green Thumb' caryophylloid dicot genus hypochondriacus 'Guarijio Grain' genus amaranthus hypochondriacus 'New Mexico' Amaranthus hypochondriacus 'Pigmy Torch' Amaranthus hypochondriacus 'Plainsman' living thing Amaranthus hypochondriacus 'Rio San Lorenzo' Amaranthus lividus Amaranthus orientalis genus amaranthus retroflexus genus amaranthus rudis caryophylloid dicot genus sp 'Tarahumara Okite' Amaranthus spinosus Amaranthus spp mix 'Magic Fountains' Amaranthus thunbergii genus amaranthus tricolor 'Aurora Yellow' Amaranthus tricolor 'Early Splendour' Amaranthus tricolor 'Elephant Head' Amaranthus tricolor 'Illumination' genus amaranthus tricolor 'Joseph's Coat' caryophylloid dicot genus tricolor 'Merah' Amaranthus tricolor 'Molten Fire' genus amaranthus tricolor 'Perfecta' ('Splendens P.') Amaranthus tricolor 'Splendens' Amaranthus tricolor,green flip (hinn choy) Amaranthus tricolor,red plant organ (red hinn choy) caryophylloid dicot genus tricolor,white leaf (white hinn choy) Amarygia parkeri x 'Alba' Amaryllis belladonna Amberboa moschata 'Imperialis Favourite' blush wine Amberboa moschata 'Imperialis Graciosa' lilac-pink Amberboa moschata 'Imperialis Lucida' red-lilac Amberboa moschata 'Imperialis Mixture,formula' genus amberboa moschata 'Imperialis Mixture,o.p.' genus amberboa moschata 'Imperialis Purple Splendour' genus amberboa moschata 'Imperialis Rosea Splendens' Amberboa moschata 'Imperialis Splendens' purple-vi asterid dicot genus moschata 'Imperialis The Bride' caucasoid genus amberboa moschata ssp suaveolens genus amberboa moschata ssp suaveolens 'Magnus' Amblygonocarpus andongensis weed artemisiifolia goody elatior Ambrosia trifida Amelanchier alnifolia Amelanchier asiatica v sinica genus amelanchier canadensis cs Amelanchier laevis cs Amelanchier lamarckii cs genus amelanchier ovalis (A.rotundifolia (Lam.)Dum.-Co. soviet russia gymnosperm genus nordmanniana 'Ambrolauri' Abies nordmanniana ssp equitrojani (A.bornmull.) gymnosperm genus numidica wings Abies phanerolepis genus abies pindrow gymnosperm genus pinsapo genus abies pinsapo 'Glauca' gymnosperm genus procera genus abies procera 'Glauca' genus abies recurvata gymnosperm genus recurvata v ernestii gymnosperm genus sachalinensis gymnosperm genus sibirica Abies animal order gymnosperm genus veitchii Abroma metropolis Abronia fragrans v fragrans genus abronia umbellata Abronia villosa Abronia villosa v aurita Abrus laevigatus Abrus precatorius Abrus sp nov genus abutilon 'Bellevue Mixed' Abutilon 'Benary's Giant' genus abutilon 'Maximum' mix Abutilon amplum Abutilon auritum Abutilon f1 'Bella pink Shades' dilleniid dicot genus f1 'Bella heavy Coral' genus abutilon f1 'Bella Mixed' nat. genus amelanchier pumila rosid dicot genus spicata Amellus tenuifolius Amethysteya caerulea Amethysteya caerulea 'Turquoise' Ammannia auriculata Ammannia coccinea Ammannia robusta Ammi majus Ammi majus 'Queen Of Africa' Ammi majus 'Snowflake' Ammi visnaga Ammobium alatum flower alatum 'Bikini' flower alatum 'Grandiflorum' Ammophila bird genus Amomum subulatum Amomyrtus lechlerana Amoreuxia palmatifida bush canescens Amorpha fruticosa pods Amorpha fruticosa cs bush nana Amorpharanthus rudis Amorphophallus bulbifer arum kiusianus Ampelodesmos mauritanicus Ampelopsis aconitifolia Ampelopsis brevipedunculata Ampelopsis camellia japonica Ampelopsis megalophylla Amphibolia maritima Amphipogon amphipogonoides Amphipogon laguroides Amphipogon strictus Amphipogon turbinatus Amsinckia angustifolia Amsinckia intermedia Amsinckia vernicosa v furcata 'Griswold Hills' dicot genus ciliata dicot genus hubrichtii genus amsonia illustris Amsonia american state dicot genus peeblesii dicot genus tabernaemontana dicot genus tabernaemontana v salicifolia Anacampseros albissima Ariamsvlei (Avonia a.) Anacampseros albissima Smorenskadu (Avonia a.) Anacampseros albissima e Kuruman (Avonia a.) Anacampseros albissima e Springbok Anacampseros albissima 'multiramosa' (Avonia a.) Anacampseros albisssima Eendoorn (Avonia a.) Anacampseros arachnoides Anacampseros arachnoides 7k. dwarf Abutilon f1 'Bella Red' Abutilon f1 'Bella food fish Shades' Abutilon geranioides Abutilon hybridum x mix Abutilon indicum Abutilon muticum genus abutilon otocarpum Abutilon palmeri dilleniid dicot genus pycnodon Abutilon sonneratianum genus abutilon suntense x genus abutilon theophrasti dilleniid dicot genus vitifolium dilleniid dicot genus vitifolium 'Album' tree 'Hollands Rock' Acacia acanthoclada tree acinacea Acacia acinacea hardy, N. tree acradenia tree acuminata Acacia acuminata 'Inland Form' Acacia acuminata ssp burkittii tree adsurgens Acacia adunca Acacia aestivalis Acacia alata tree alcockii tree alleniana tree amblygona Acacia amoena Acacia ampliceps Acacia amythethophylla tree anaticeps tree anceps tree anceps v angustifolia tree ancistrocarpa Acacia andrewsii tree aneura tree aneura v macrocarpa Acacia angusta Acacia angustissima Acacia angustissima prov. tree melleodora Acacia mellifera tree menzelii tree merinthophora Acacia merrallii Acacia microbotrya Acacia microcarpa Acacia mimula tree modesta Acacia moirii ssp dasycarpa tree mollifolia Acacia american state tree monticola tree montis-usti Acacia mountfordae Acacia mucronata Acacia mucronata ne Rosh Pinah Anacampseros arachnoides Calitzdorp Anacampseros arachnoides Redhouse-Despatch Anacampseros arachnoides Vredendal Anacampseros australiana Anacampseros baeseckeri Anacampseros baeseckeri Koringhuis Anacampseros baeseckeri w Platbakkies Anacampseros baeseckeri aff Wormskioldia Anacampseros densifolia Anacampseros filamentosa Anacampseros filamentosa ssp tomentosa Anacampseros filamentosa ssp tomentosa softcaudex Anacampseros herreana Kuboos, Rv.


Use this simple recipe to enjoy these Japanese scallops. which are full of savory flavor.
Crisp,light panko bread crumbs beautifully complement these meaty scalops. You can also use scallops in the shell. If you do, then place the panko bread crumbs directly on top of the scallops and bake them in a toaster oven.
4 Arrange 3 on a platter and garnish with chervil.


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Base ten decimal number 48.25 converted to 32 bit single precision IEEE 754 binary floating point standard
How to convert the decimal number 48.25(10)
1. First, convert to binary (base 2) the integer part: 48. Divide the number repeatedly by 2, keeping track of each remainder, until we get a quotient that is equal to zero:
48(10) =
11 0000(2)
3. Convert to binary (base 2) the fractional part: 0.25. Multiply it repeatedly by 2, keeping track of each integer part of the results, until we get a fractional part that is equal to zero:
1) 0.25 × 2 = 0 + 0.5;
2) 0.5 × 2 = 1 + 0;
0.25(10) =
48.25(10) =
11 0000.01(2)
11 0000.01(2) =
11 0000.01(2) × 20 =
1.1000 001(2) × 25
Mantissa (not normalized): 1.1000 001
7. Normalize mantissa, remove the leading (the leftmost) bit, since it's allways 1 (and the decimal point, if the case) then adjust its length to 23 bits, by adding the necessary number of zeros to the right:
1. 100 0001 0000 0000 0000 0000 =
Number 48.25, a decimal, converted from decimal system (base 10)
-0.035 = 1 - 0111 1010 - 000 1111 0101 1100 0010 1000 Jul 18 15:07 UTC (GMT)
-0.000 000 000 931 322 574 615 47 = 1 - 0110 0000 - 111 1111 1111 1111 1111 1111 Jul 18 15:06 UTC (GMT)
-1.356 223 5 = 1 - 0111 1111 - 010 1101 1001 1000 1011 1011 Jul 18 15:06 UTC (GMT)
-0 = 1 - 0000 0000 - 000 0000 0000 0000 0000 0000 Jul 18 15:06 UTC (GMT)
0.166 666 666 = 0 - 0111 1100 - 010 1010 1010 1010 1010 1010 Jul 18 15:06 UTC (GMT)
33.203 125 = 0 - 1000 0100 - 000 0100 1101 0000 0000 0000 Jul 18 15:06 UTC (GMT)
28 = 0 - 1000 0011 - 110 0000 0000 0000 0000 0000 Jul 18 15:06 UTC (GMT)


Can't Swim, still pretty fresh to the scene, have gained a great following since their arrival in 2015. With their second studio album 'This Too Won't Pass' has it's dark turns in relations to ex-relationships, expressing the emotions through the power of music.
With lines like "Blocking out our future with my past" from My Queen and "The writings on the photo that you gave to me, is all I have left" from their latest single Sometimes You Meet The Right People At The Wrong Times (which is what the message read on the photo according to the band). Moving away from their lyrical content, Can't Swim have provided some really powerful rock grooves that lend a catchy hook instrumentally through the album, so regardless of the dark lyrics the physique of most tracks have an uplifting effect that can leave you confused to be singing along with such anguish based wordings while having a clear head of hearing more major key notes. As you get deeper into the album you start to realise the tracks become less about that happy vibe instrumentally, slowing things down or hitting you with straight chord progressions that let you focus more on the point of the album – break ups and uncertainty of love. Amnesia 666 sees himself questioning "did I love her?" and closing the album with howling cries "Forever in regret" on Winter Of Cicada.
The concept of the album is a very common source of influence, but Can't Swim have dissected and re-articulated that straight line to create waves and forming a beautiful laid out release. With their short careers there is so much more this band can progress onto be a huge impact for the years to follow.


text:
Brazil and the "Dutch disease"
October 29, 2009 By dduane in "Dutch disease", economics, Vocabulary Tags: currency, economy, emerging markets, finance, investing	Leave a comment
In many ways, Brazil can be seen as the premier growth story so far in the new century. The country has always been blessed with abundant mineral and agricultural resources. What's new is that it has finally been able to shake off the legacy of decades of economic mismanagement. Brazil's GDP now ranks it as one of the top ten economies in the world.
Brazil's prosperity, and the resulting inflow of foreign capital, have caused commentators to worry that the country is suffering from "Dutch disease," an economic challenge named after conditions in the Netherlands after discovery of massive offshore natural gas deposits there.
What is the "Dutch disease"?
It has two elements:
1. a sharp rise in the exchange rate, as foreign money pours into the country to purchase output from existing mineral deposits and to own and develop new ones;
2. severe problems in non-resource traded goods industries. The higher exchange rate makes output more expensive, hence less attractive, to customers abroad, and the booming resource industry attracts capital and workers to it, raising the cost of both for every domestic company.
Since when is an economic boom a problem?
1. the economy of a natural resources-driven country becomes hostage to the booms and busts of demand for its commodities;
2. the country can end up with no advanced service or manufacturing industries of its own, to offset commodity downturns, or to be there when the deposits eventually run out.
What about Brazil?
The Netherlands is a tiny country. Brazil has the sixth largest population on earth. So having all the working-age population pulled into natural resource development isn't an issue.
But the exchange rate is. The real is up 36% against the dollar so far this year (the US is Brazil's largest trading partner), and the country is awash in foreign currency inflows, both foreign direct investment and portfolio capital.
Brazil is concerned, as it should be. It believes the portfolio inflows are primarily speculative, however, and has just instituted a 2% tax on them. The tax doesn't apply to Brazilian ADRs traded in the US, by the way–and will likely not have much effect, other than to set creative minds to work on ways to get around the levy.
The situation bears watching.
For non-resource industries in a "Dutch disease" country, the best solution is government subsidy to encourage increased productivity and innovation in industries hurt by currency appreciation. Import barriers, which would constitute a return to the bad old days, are unlikely, I think, but still something to be on the alert for.
Should the flows reverse, I imagine Brazil would heave a sigh of relief and wave the money goodbye, even though the departures would cause short-term pain. The only country in (my) recent memory to stop outflows with capital controls is Malaysia. As I see it, that action has destroyed the country's investment appeal to all but the most highly specialized portfolio investors since.
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text:
d1161687_13-g.htm
Expires: February 28, 2011
hours per response………11
SCHEDULE 13G
(Amendment No. )*
Tree.com, Inc.
(Name of Issuer)
Common Stock, $.01 par value
(Title of Class of Securities)
(CUSIP Number)
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
[_] Rule 13d-1(b)
[x] Rule 13d-1(c)
[_] Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
CUSIP No
NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Second Curve Capital, LLC
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) [_]
(b) [x]
SEC USE ONLY
CITIZENSHIP OR PLACE OF ORGANIZATION
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
SOLE VOTING POWER
SHARED VOTING POWER
SOLE DISPOSITIVE POWER
SHARED DISPOSITIVE POWER
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
[_]
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
Thomas K. Brown
(a).
Name of Issuer:
(b).
Address of issuer's principal executive offices:
11115 Rushmore Drive
Name of person filing:
Address or principal business office or, if none, residence:
237 Park Avenue, 9th Floor
c/o Second Curve Capital, LLC
(c).
Citizenship:
Second Curve Capital, LLC - Delaware
Thomas K. Brown – United States
(d).
Title of class of securities:
(e).
CUSIP No.:
If This Statement is filed pursuant to §§.240.13d-1(b) or 240.13d-2(b), or (c), check whether the person filing is a
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);
A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C.1813);
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);
Group, in accordance with §240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution:
Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.
Amount beneficially owned:
Second Curve Capital, LLC – 736,675
Thomas K. Brown - 736,675
Percent of class:
Second Curve Capital, LLC – 6.6%
Thomas K. Brown – 6.6%
Number of shares as to which the person has:
Sole power to vote or to direct the vote
Second Curve Capital, LLC – 0
Thomas K. Brown – 0
Shared power to vote or to direct the vote
Thomas K. Brown – 736,675
Sole power to dispose or to direct the disposition of
Shared power to dispose or to direct the disposition of
Instruction: For computations regarding securities which represent a right to acquire an underlying security see §240.13d-3(d)(1).
Ownership of Five Percent or Less of a Class.
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [_].
Ownership of More Than Five Percent on Behalf of Another Person.
If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
If a parent holding company or control person has filed this schedule, pursuant to Rule 13d-1(b)(1)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company or control person has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary.
Identification and Classification of Members of the Group.
If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(J), so indicate under Item 3(j) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identity of each member of the group.
Notice of Dissolution of Group.
Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5.
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
By: /s/ Thomas K. Brown
Name: Thomas K. Brown
Title: Managing Member
/s/ Thomas K. Brown*
* The Reporting Person disclaims beneficial ownership in the common stock reported herein except to the extent of his pecuniary interest therein.
The original statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If the statement is signed on behalf of a person by his authorized representative other than an executive officer or general partner of the filing person, evidence of the representative's authority to sign on behalf of such person shall be filed with the statement, provided, however, that a power of attorney for this purpose which is already on file with the Commission may be incorporated by reference. The name and any title of each person who signs the statement shall be typed or printed beneath his signature.
Note. Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See s.240.13d-7 for other parties for whom copies are to be sent.
Attention. Intentional misstatements or omissions of fact constitute Federal criminal violations (see 18 U.S.C. 1001).
The undersigned agree that this Schedule 13G, Amendment No. 1 dated December 31, 2010 relating to the Common Stock, $.01 par value of Tree.com, Inc. shall be filed on behalf of the undersigned.
/s/ Thomas K. Brown
SK 21989 0009 1161687


text:
Links To Articles On Pregnancy And Sushi
To begin we would like to reprint the Mercury Levels - Which Fish Is Safe - list from FDA/EPA:
The U.S. Food and Drug Administration considers mercury levels below 1 part per million acceptable, though it warns against shark and mackerel, too. The Environmental Protection Agency has a lower threshold, about 0.2 ppm.
FISH MERCURY (PARTS PER MILLION)
Tilefish 1.45
Swordfish 1.00
Shark 0.96
King mackerel 0.73
Largemouth bass 0.52
Tuna (fresh or frozen) 0.32
Tuna (canned) 0.17
Salmon 0
In the 1950s, women in Minimata, Japan, exposed to high levels in fish gave birth to children with grievous birth defects. Since then, it has become clear that even low levels of mercury exposure in women can cause neurological problems in their children, affecting language, hearing, and movement. Today, the Environmental Protection Agency estimates that 8 percent of American women of childbearing age have blood mercury levels that could endanger their children. As a result, over 60,000 children are born each year at risk of lifelong problems, according to the National Academy of Sciences. Young children also can be harmed by mercury in the food they eat, because their brains are still actively developing.
- Read the complete version of this article on food safety.
- Go to EPS esbite Mercury section, and read What You Need to Know about Mercury in Fish and Shellfish
2004 EPA and FDA Advice for:
Women Who Might Become Pregnant
Women Who are Pregnant
Be Cautious When Cooking
When people eat raw, uncooked, or improperly or inadequately cooked/handled seafood, they are taking health risks. Microorganisms in raw seafood are hidden; sometimes, experts even have trouble detecting them. Freezing fish will only kill mature parasitic worms. The only way to fully kill worm eggs and other microorganisms is by fully and properly cooking fish. This is the best way to avoid any unwanted sickness. The safest way to enjoy sushi is to choose the fully cooked or vegetarian varieties, such as those that include cooked seafood [e.g., fully cooked eel (unagi) or shrimp (ebi)], vegetables [e.g., cucumber (kappa) maki], avocado (e.g., California roll), and other ingredients.
- from Columbia University
Is It Safe To Eat Sushi During Pregnancy?
Some types of sushi, such as California rolls (which contain steamed crab) and cooked eel, are fine to eat while you're pregnant. But you should avoid eating the kinds that contain raw seafood, such as tuna...
Will I Be Able To Eat Sushi While I Breastfeed Without Any Risk To My Newborn?
One of the biggest myths surrounding breastfeeding is that there is a long list of foods that nursing mothers need to avoid. In reality, there are very few if any foods that all nursing mothers need to avoid. Certainly there are foods such as caffeine and alcohol that less is better than more, but for the most part, you are free to eat just about anything. Some general guidelines...
WebMD – Anything Fishy About Sushi?
I think sushi is generally safe for pregnant women. I looked through all of the medical literature and couldn't find any conclusive studies showing that sushi could harm a woman or fetus during pregnancy. And my pregnant Japanese patients tell me that women in Japan do eat sushi when they're pregnant, and that many books suggest eating it as part of a healthy, low-fat diet...
WebMD – Supping On Seafood While Pregnant
Fish is a healthful alternative to red meat during pregnancy and supplies hefty amounts of the type of oils, called omega-3 fatty acids, needed for the development of your baby's vision and nervous system. However, some seafood is safer than others...
Ginger And Miscarriage – Is It Okay To Drink Ginger Tea When You're Pregnant?
Small amounts of fresh ginger are probably okay, but large amounts of ginger may contribute to contractions of the uterus, and this may be more pronounced in women who have had a miscarriage...
Fish: Not Always Safe For Moms-To-Be
The Food and Drug Administration (FDA) is announcing its advice to pregnant women and women of childbearing age who may become pregnant on the hazard of consuming certain kinds of fish that may contain high levels of methyl mercury...
Sushi Without Fish - Vegetarian Sushi (Essential Kitchens)
A fun, flavorful alternative to traditional sushi, vegetarian sushi is sure to please even non-adventurous diners. With Vegetarian Sushi readers will learn everything needed to make this delicious sushi at home. Part of the popular Essential Kitchen series, this edition provides a wide variety of recipes focusing on sushi rolls, molded sushi, noodle sushi, omelet sushi, sushi in a bowl, as well as soups, sauces and pickles to accompany each dish. Specific recipes include Peach and Coconut Sushi Roll, Cucumber and Sesame Sushi Rolls, Spinach and Roasted Pine Nut Sushi Rolls, Pickled Plum and Brown Rice Rolls, Soba Noodle Sushi, Tofu Donburi, Miso Soup with Daikon and Carrot, and more.
Vegetarian Sushi Made Easy
When most Westerners hear the word "sushi", they think of nigiri-zushi, or "finger sushi", the super-fresh strips of raw filleted fish on top of a smal mound of vinegared rice. But finger sushi is just one of many kinds of sushi found in Japan, and Vegetarian Sushi Made Easy introduces over 40 recipes for delicious, safe, easy-to-prepare sushi made with vegetables instead of raw fish. The recipes use a wide variety of vegetables readily available in regular and Asian grocery stores, and the instructions are clear and simple, with ample diagrams illustrating preparation steps. Not only is vegetarian sushi very healthy - low in fat and high in fiber, vitamins, and minerals - but it is fun and easy to make.
Vegetarian Sushi Made Easy is the perfect introduction for all cooks, both amateur and experience, to the wide world of healthy, delicious sushi.
main - introduction | all about sushi | sushi recipes
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text:
Q: Is there an analog of 'Directed Graph' for topological spaces? In a directed graph, certain paths are distinguished: Those that follow the edge direction on each edge. I was wondering if one could (or does) formulate a notion of a 'Directed Topological Space', on which certain paths are distinguished. Conceptually, we could take a space like R^2 \ 0 and say that counterclockwise paths are the 'directed paths'.
I had two ideas: First, if you have a smooth Riemannian manifold, then a smooth vector field X gives you a 'Direction': The directed paths being those whose tangent vector v satisfies g(v,X) > 0 everywhere.
Alternatively, with an arbitrary topological space, you could say that a 'Directed' space comes equipped with a sorting of homotopy classes of paths into 'Forward', 'Backward', and 'Trivial' (the last consisting of just trivial loops), where the compositions 'Forward'*'Forward' = 'Forward', 'Forward'*'Trivial' = 'Forward', etc. and the reverse of a 'Forward' path is always a 'Backward' path (note that you wouldn't have any results involving 'Foward'*'Backward' or 'Backward'*'Forward').
So I suppose my question is: Is this idea studied at all? Has anyone determined this (or perhaps another generalization of 'Directed') to be a useful notion?
Thanks.

A: Partially ordered sets are closely related to directed graphs, and partially ordered spaces have been studied in general topology quite a bit since there is a strong connection between ordered sets and topologies. I realize that this may not be exactly what you had in mind since you may have been concerned mainly with paths on such spaces, but I will answer this question since ordered topological spaces are very interesting and very natural. Besides, one may also consider paths on ordered topological spaces as order preserving continuous maps from $[0,1]$ to your space $X$. Furthermore, I suppose that you can probably generalize this notion to a "locally ordered topological space" or a "locally preordered topological space" so that you can consider $\mathbb{R}^{2}\setminus\{0\}$ with a notion of going clockwise and counterclockwise. I will briefly outline some basic ordered topological spaces here.
If $X$ is a topological space, then the specialization ordering on $X$ is the preordering $\leq$ on $X$ such that $x\leq y$ if and only if $x\in\overline{\{y\}}$. Furthermore, the specialization ordering on $X$ is a partial ordering if and only if $X$ is a $T_{0}$-space. It follows from the definition that $X$ is a $T_{1}$-space if and only if the specialization ordering $\leq$ coincides with equality. Thus the specialization ordering is next to useless for spaces satisfying separation axioms from $T_{1}$ and above. However, the specialization ordering is very important for analyzing spaces that do not satisfy the $T_{1}$-separation axiom.
As another example of an ordered topological space, an Alexandroff space is a topological space where the arbitrary intersection of open sets is open. The category of Alexandroff spaces is isomorphic to the category of all preordered sets where the morphisms between preordered sets are the order preserving maps. If $X$ is an Alexandroff space, then the specialization ordering gives you a preordering on $X$. If $X$ is a preordered set, then the collection of all downwards closed sets are precisely the closed sets in an Alexandroff topology on $X$. These correspondences give you the equivalence between the category of Alexandroff spaces and the category of partially ordered sets.
Also, people have endowed partially ordered sets with other topologies such as the Lawson topology and Scott topology (see the book Continuous Lattices and Domains or the book the Compendium of Continuous Lattices) for more details. The Scott topology almost never satisfies higher separation axiom, but it turns out that the Lawson topology is compact and Hausdorff on a large class of ordered sets called continuous lattices.
Other ordered spaces that satisfy higher separation axioms are also useful.
For instance, one can use ordered compact Hausdorff spaces in order to study distributive lattices. We say that a topological space $X$ with a partial order $\leq$ is totally order disconnected if whenever $x\not\leq y$, then there is an upwards closed clopen set $U$ with $x\in U,y\not\in U$. A Priestley space is a compact totally order disconnected topological space. It turns out that the category of Priestley spaces is equivalent tot the category of all ordered topological spaces.
In my own personal research I have studied connections between least upper bounds in posets and topological spaces, and this research is quite similar to the Scott topology on a topological space. In my research, I have shown that a certain category of zero-dimensional ordered topological spaces is isomorphic to a category certain of pairs of the form $(X,\mathcal{A})$ where $\mathcal{A}$ is a collection of subsets of $X$ with least upper bounds.

A: There is quite a growing number of researchers nowadays in so-called "Directed Algebraic Topology" (it even has its own Wikipedia page). It can be seen as part of Applied Algebraic Topology, since it arose out of an attempt to model concurrent systems in Computer Science.
I can recommend the papers of Fajstrup, Raussen and Goubault (linked to from the Wiki page) and Jeremy Gunawardena on homotopy and concurrency as good introductions to the subject of directed homotopy.


Banaras, Varanasi or Kasi is a Kaleidoscope. It is also a phoenix among cities having emerged more vibrant and colorful from the many destructions it has faced.
It is considered the home of 330 million gods who are held together by an enormous corpus of mythology and are the very essence of the city. The human endeavor is equally inspiring. Rich textiles, Unique handicrafts, delectable food, intriguing aghoris, eternal ganga, serene Ghats, the ever consuming flames of Manikarnika and the adobe of Lord Vishwanath and much more. In the tradition of Annapoorni, the goddess of food, this city whets the appetite of the scholar and the layman.
Mystical Palmyra is proud to bring to you for the very first time a very unique experience that captures a slice of the human and the divine. Prof Madhusudhanan Kalaichelvan would unveil the mysteries surrounding the temples and the gods. Authentic Banarasi food, traditional weaving, trip down the ganga, the serene Ghats, the outstanding places of learning, Sarnath…..it is a packed eclectic itinerary that awaits you. For the true flavour of the city to sink in we have designed various walks. Come with us to savour this city which predates history and promises eternal Moksha.
2 bottles of water per person will be provided on the vehicle every day. We request you to bring a refillable bottle in order to reduce the usage of plastic waste.
As the perennial river Cauvery the town of Tiru-Chirra-Palli or Trichy was and is perennial. Situated in the heart of Tamilnadu this city boasts of a glorious past and ultra-modern future "Smart City". It's name gives us a clue of the ancient traditions it has as a part of its location on the Kaveri river bank.
The name denotes an ancient Jain vow of fasting to death. Mystical Palmyra along with Historian Pradeep Chakravarthy wafts you on a two day trip to explore the region's rich history and of course the jewel in the crown, the Bhooloka Vaikuntam – Srirangam.
Hampi (derived from Pampa) is the grand testimony to the mighty Vijayanagara empire. Though not a thriving city today, the relics bear irrefutable evidence of a vibrant and colorful society that adorned these beautiful edifices. Let us be captivated by visiting this ancient habitation which was the then "city of the future".
The palaces, the temples, the bazaars, the towers, arches are ample testimony to a vibrant and economically mighty kingdom of yester years. Today it is rightfully a UNESCO World Heritage Site. Irrigation, architecture, dwellings, places of worship or individual poetries in stone and yet they come together in a grand mosaic that stuns and holds you spellbound. Let us peruse a few stanzas of this eloquent ballet over a four-day sojourn curated by Mystical Palmyra along with Prof Madhusudanan Kalaichelvan.


Jasper Newton "Jack" Daniels was born in 1850, making 2010 his 160th birthday, no one is quite sure which day he was born as the courthouse records were destroyed in a fire, so its customary to spend the month celebrating and who are we to argue.
The Madtini Labs gang is happy to join in the celebration and sending birthday wishes to 'Jack' with a selection of our favorite cocktail recipes available on their website.
Join with us and enjoy one of these delicious cocktails.
Jack is the only bourbon, Kentucky Bourbon is the only way to fly. I LOVE that corkscrew topped martini pick, where'd you find them?


Movie Poster Design by Star Wars Trilogy. Officially licensed, screen printed Star Wars posters. Edition of 400. Client: Lucasfilm/Mondo. CATEGORIES Design News, Featured Design News, HOW Blog. TAGS best movie posters, design competitions, design contests, great movie posters, HOW Poster Design Awards, poster design awards, poster design competition, poster design contests. …... The World's Greatest Star Wars Vintage Movie Posters * Vintage Original Movie Posters * Star Wars Posters * Star Wars Movie Posters * Star Wars Film Posters Please scroll down or use the links above to see our entire Star Wars inventory.
The World's Greatest Star Wars Vintage Movie Posters * Vintage Original Movie Posters * Star Wars Posters * Star Wars Movie Posters * Star Wars Film Posters Please scroll down or use the links above to see our entire Star Wars inventory.
"This was not really a research book," says Jonathan Rinzler about Star Wars Posters. "George really wanted to show the posters without credits.
Lucasfilm stopped the shipping of the posters and sold the remaining stock of 6,800 posters to Star Wars fan club members for $9.50.  Star Wars: Episode III – Revenge of the Sith , released in 2005 as part of the prequel trilogy, later alluded to the dismissed title Revenge of the Jedi .
Drive Movie Poster Movie Poster Art Poster Drawing Poster Series New Poster Alternative Movie Posters Great Movies Awesome Movies Soundtrack Forward Drive Cityscape version, by Tyler Stout, regular edition of (signed and numbered).
Star Wars fan and artist, Shane Molina, seems to have had it with Porg mania and drafted up a disturbing poster of a decapitated Porg at the hands of a First Order Stormtrooper.