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Will Gov. Pawlenty appoint Minnesota Senator on January 6?
Franken Leads, Court Battle Is On In Minnesota Senate Race
John Gizzi
As of Tuesday, December 23, lawyers representing the two major candidates in the Minnesota Senate race were before the state Supreme Court arguing about the status of duplicate ballots. According to the Minneapolis Star Tribune, the closest U.S. Senate race in the nation now has Democratic challenger Al Franken leading Republican Sen. Norm Coleman by 46 votes out of approximately 2.92 million cast. Secretary of State Mark Ritchie told MSNBC that about 1000 to 2000 ballots remain to be tallied.
Counted and now in a recount, the Franken-Coleman bout has now taken longer than Florida did to count its presidential ballots in 2000, hanging chads and all.
Coleman clung to a lead of less than 1,000 votes throughout the initial count and much of the recount. On Friday (December 18), Franken moved ahead for the first time and by a microscopic margin.
"I wouldn't describe anything as fraudulent — nothing at all," Minnesota Republican Party Communications Director Gina Countryman told me, "Our concern is making sure everything is counted, fairly and once."
Countryman was referring to the duplicate ballots that are now the subject of argument in court. She explained there are original ballots (with which the voter actually votes) and duplicates (which show a vote was cast). The GOP spokeswoman pointed out that in an estimated 25 precincts, "they don't have the same number of duplicates as ballots."
Both Countryman and Coleman campaign spokesman Mark Drake pointed out to me that it was solely on the basis of the duplicate ballots that Franken moved ahead of Coleman on December 18. Much like the hanging chads in Florida in 2000, the duplicate ballots are at the heart of the Franken-Coleman dueling before the state Supreme Court. According to Minnesota Public Radio, "Coleman's campaign wants the court to stop the canvassing board from counting duplicate ballots and also wants election officials to go back and see if any ballots were counted twice." In addition, MPR reports, "Ritchie, Attorney General Lori Swanson, the Franken and Coleman campaign local elections officials [have presented] a motion to the Minnesota Supreme Court asking them to approve a revised plan regarding wrongly rejected absentee ballots."
With the courts taking a holiday break, a decision is expected on both these motions sometime next week. Historically, courts move swiftly on election issues.
The next critical date in the timeline is December 30, when the Canvassing Board deals with recounted votes, challenges to ballots, and the final tallies. (The five-person board consists of Chief Justice Eric Magnuson and Justice Barry Anderson of the Supreme Court, both appointed by Republican Gov. Tim Pawlenty; Ramsey County Judiciary Court Chief Judge Kathleen Gearin, a Democrat, and Judge Edward Cleary appointed by former Reform Party Gov. Jesse Ventura, and Secretary of State Ritchie, Democrat.)
On December 31, the state Canvassing Board is expected to complete its count. This is also the same date that the Supreme Court has set as the deadline for local officials to submit wrongly-rejected absentee ballot numbers to the Secretary of State's office. Obviously sensing that it may not have its work completed on the 31st, the Canvassing Board asked for an extension until January 2nd to complete its counting.
On January 4, the office of Secretary of State Ritchie has to open and count the absentee ballots which are believed to have been wrongly rejected and determine which are legitimate votes. The next day, the Canvassing Board will accept results from absentee ballots and deal with the challenges to these absentee ballots.
If there are disputes remaining over absentee ballots, or regarding the number of ballots and duplicates by January 6th, and lawyers for either candidate file contests, then there will most likely be no certification of a winner.
January 6 is a red-letter date. That is when the new Congress is sworn in and Coleman's current six year term expires. If that is the case, then Republican Gov. Tim Pawlenty could appoint someone to fill the Senate until the Franken-Coleman showdown is resolved and someone is certified the winner.
But that may not be the case and, should Pawlenty choose to appoint someone, the Senate may not seat the appointee. A spokesman for Senate Democratic Leader Harry Reid told MPR's Tom Scheck: "It's perfectly acceptable for us to just wait to seat somebody until somebody is certified by the state."
Being Good for God's Sake
The Year Of Leg Thrills
Written By John Gizzi
John Gizzi has come to be known as �??the man who knows everyone in Washington�?� and, indeed, many of those who hold elected positions and in party leadership roles throughout the United States. With his daily access to the White House as a correspondent, Mr. Gizzi offers readers the inside scoop on what�??s going on in the nation�??s capital. He is the author of a number of popular Human Events features, such as �??Gizzi on Politics�?� and spotlights of key political races around the country. Gizzi also is the host of �??Gizzi�??s America,�?� video interviews that appear on HumanEvents.com. Gizzi got his start at Human Events in 1979 after graduating from Fairfield University in Connecticut and then working for the Travis County (Tex.) Tax Assessor. He has appeared on hundreds of radio and TV shows, including Fox News Channel, C-SPAN, America's Voice,The Jim Bohannon Show, Fox 5, WUSA 9, America's Radio News Network and is also a frequent contributor to the BBC -- and has appeared on France24 TV and German Radio. He is a past president of the Georgetown Kiwanis Club, past member of the St. Matthew's Cathedral's Parish Council, and secretary of the West End Friends of the Library. He is a recipient of the William A. Rusher Award for Journalistic Excellence and was named Journalist of the Year by the Conservative Political Action Conference in 2002. John Gizzi is also a credentialed correspondent at the World Bank and the International Monetary Fund. He has questioned two IMF managing directors, Dominique Strauss-Kahn and Christine LaGarde, and has become friends with international correspondents worldwide. John�??s email is JGizzi@EaglePub.Com


These wonderful silk parachutes are sure to delight as children throw them up in the sky and watch them float back down. They are easy to throw and do not tangle as the parachute opens and glides down. The attached pouch can carry a small doll or figure that can take a ride in the pouch! Available in blue and pink.
...it floats gently to earth!


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Bella Tan 0 May 19, 2021 1:46 am
While there aren't as many female idols with tattoos as there are male idols, the ones who do rock them with confidence. From colorful and playful lit
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While there aren't as many female idols with tattoos as there are male idols, the ones who do rock them with confidence. From colorful and playful little pieces to heartfelt phrases, here are some female idols who aren't afraid to show off their tattoos.
HyunA has many small tattoos dotted across her body, one of them being her cute row of colored emoji faces. Many of them are forms of lettering, like the phrase "My mother is the heart that keeps me alive" written on the back of her shoulder.
2. MAMAMOO's Hwasa
Hwasa has six tattoos, from her baptismal name "Maria" written on the back of her neck, to a matching tattoo with Wheein of the word "Caddo" on the side of her neck, meaning "someone who carries your sorrows on her back."
| @_mariahwasa/Instagram
3. MAMAMOO's Wheein
Wheein has more than 10 tattoos, like two colorful butterflies on her forearm and a small watercolor flower on her hand.
| @sinewpark_tt/Instagram
4. MAMAMOO's Moonbyul
Moonbyul also has a collection of six tattoos scattered across her body, from a line art style family portrait on the back of her arm, to a timeline of important events in her life on her ankle.
5. F(x)'s Amber Liu
Amber is one of the few k-pop idols with a full tattoo sleeve, a collection of both meaningful and spontaneous tattoos that act as personal memories saved on her skin.
| @ajol_llama/Instagram
6. (G)I-DLE's Soojin
Soojin has eight tattoos, all done in a simple minimalist style like the cross on the back of her shoulder, a cloud inside her finger, and "self love is the best love" written on her upper arm.
| @official_g_i_dle/Instagram
7. (G)I-DLE's Yuqi
Yuqi has an adorable Welsh Corgi tattoo on the back of her right shoulder!
| @secretyena/Twitter
8. (G)I-DLE's Soyeon
Soyeon also only has one tattoo, a lotus flower she got earlier this year.
| @G_I_DLE/Twitter
9. TWICE's Chaeyoung
Chaeyoung is another idol with a variety of small and cute tattoos, from two little tomatoes on her upper arm, to a line of four carrots on her forearm.
10. Girls' Generation's Taeyeon
Taeyeon has multiple small tattoos as well, with these four delicate colored flowers across her collarbone and shoulders being the most recent additions. Her other tattoos are located in places like the back of her neck, the inside of her fingers, and her arms.
| @taeyeon_ss/Instagram
11. Red Velvet's Yeri
Yeri's tattoos are all words, with "influence" inside her finger, "aurora" inside another finger, and "stability" on the back of her neck.
| @kyr935/Twitter
12. Red Velvet's Wendy
Wendy was spotted with a few tattoos in the music video for "Psycho", including a small cross in the middle of her chest, "you are in my heart" written across her collarbone, and a finger tattoo that says "love".
| Red Velvet/YouTube
13. BLACKPINK's Jennie
Jennie, in fact, did have a tattoo pre-debut!
She sported a temporary tattoo on her wrist with the words "Stay Strong" designed in cursive.
She used it as a reminder to keep holding on to her dream of being an idol. As she trained for six years in YG Entertainment before her debut in 2016, it was a long and arduous journey for her.
The tattoo marked her insecurities that she wouldn't ever debut. Now, Jennie is one of the most recognized celebrities both locally and internationally.
She may no longer have the tattoo, but Jennie proves that she really did stay strong!
BLACKPINK's Jennie Shows Off Her Tiny Waist In New Mirror Selfies
Krispy Kreme Teases BLACKPINK Themed Donut To Release This Month

redpajama_set_name: RedPajamaCommonCrawl


Short description: Dyche's "Guide to the English Tongue"
Medium description: Thomas Dyche's "Guide to the English Tongue".
Similar to many schoolbooks of the time, it differed in its methodical treatment of pronunciation with words group not only by number of syllables but also by the stressed syllable. Also introduced the double accent as a mark for when a word spelt with a single consonant that is pronounced twice.


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Spotlight on Northern Ireland in Atlanta, Georgia
Tourism Ireland promotes Northern Ireland at 2017 Stone Mountain Highland Games
Representatives of the Ulster Historical Foundation, the Ulster-Scots Agency, Dalriada Kingdom Tours, Visit Armagh, Mid and East Antrim and Brack Tours travelled to Georgia in the United States, to join Tourism Ireland for this year's Stone Mountain Highland Games. Tourism Ireland also invited Stonewall Folk Group, from Co Armagh, to entertain visitors to the Games.
Now in its 45th year, the Stone Mountain Highland Games is an annual event which takes place in Stone Mountain Park, north-east of Atlanta in Georgia. Attracting almost 30,000 visitors of Scots-Irish and Scots descent during the two-day festival, the games are an ideal opportunity for Tourism Ireland to highlight Northern Ireland as a wonderful holiday destination.
In advance of this year's Games, influential journalists, travel trade and airline contacts from Atlanta were invited to a lunch event by Tourism Ireland – where they met with the various companies from Northern Ireland to hear about what Northern Ireland has to offer American holidaymakers.
Alison Metcalfe, Tourism Ireland's Head of North America, said: "Tourism Ireland was delighted to participate in the Stone Mountain Highland Games once again this year. Our presence at the Games is a key element of our ongoing activity to showcase Northern Ireland as a compelling holiday destination in the United States, helping us to keep Northern Ireland high on the vacation 'wish-list' of Americans for 2018. Tourism Ireland recognises the potential of the Ulster Scots segment for tourism to Northern Ireland and specifically promotes to this audience, focusing on the strong ancestral links between this part of the US and Northern Ireland."
Tourism Ireland has been targeting people of Ulster-Scots descent in the US for a number of years now. Promotions have included extensive publicity campaigns, advertising in newspapers in the southern states of the US, communications with "best prospects" who have Northern Ireland surnames, as well as participation in promotions like the Stone Mountain Highland Games.
Participants at the Stone Mountain Highland Games with Billy Condon (standing, fifth right) and Virginia Goff (kneeling, centre), both Tourism Ireland; Shane Stevenson, Consul General Ireland (standing, centre); and Jeremy Pilmore-Bedford, Consul General United Kingdom (standing, fourth right).
Lonely Planet declares Belfast and the Causeway Coast the Number One Region in the world to visit in 2018


California's Environmental Principles and Concepts have a timely and relevant place in the new state frameworks.
In 2003, the California Education and the Environment Initiative, Assembly Bill 1548, was passed by California's legislature and signed into law by the governor. It called upon multiple state agencies, including the State Board of Education, California Department of Education, and Natural Resources Agency, to work with the California Environmental Protection Agency and Integrated Waste Management Board (now CalRecycle) to implement several initiatives intended to increase the environmental literacy of students throughout the state's K–12 education system.
In 2004, identification of key environmental content resulted in the development and adoption of California's Environmental Principles and Concepts (EP&Cs). Developed by more than 100 scientists and technical experts, they examine the interdependence of human societies and natural systems, and are the foundation of the model Education and the Environment Initiative Curriculum.
We and our partners work to raise awareness of the EP&Cs; sharing them at statewide rollouts of new standards, with instructional materials publishers in exemplars, and with the California Subject Matter Project, where they are being integrated into professional learning courses for teachers.
Principle I: The continuation and health of individual human lives and of human communities and societies depend on the health of the natural systems that provide essential goods and ecosystem services.
Principle II: The long-term functioning and health of terrestrial, freshwater, coastal, and marine ecosystems are influenced by their relationships with human societies.
Principle III: Natural systems proceed through cycles that humans depend upon, benefit from, and can alter.
Principle IV: The exchange of matter between natural systems and human societies affects the long-term functioning of both.
Principle V: Decisions affecting resources and natural systems are based on a wide range of considerations and decision-making processes.
These curriculum frameworks provide guidance for implementing the content standards adopted by the State Board of Education. Standards are often referred to as the what students should learn and be able to do, while the curriculum framework is the document that provides the how. California frameworks also play a part in determining which textbooks and other instructional materials are approved by the Board for use in classrooms statewide.
For many decades, California has been a national leader in educating students about the environment, and now more than ever, the state recognizes that environmental literacy is crucial to sustaining the economic and environmental wellbeing of all Californians. This is embodied in the California Education Code and reflected in the educational mandates of many state agencies. Environmental literacy means more than knowing environmental content; it also encompasses civic engagement and community involvement in diverse settings. Going beyond the walls of the classroom, environmental literacy can be developed through investigations on campus, in the local community, at nature centers and outdoor schools, as well as in the rich and diverse natural landscapes found throughout California.


This is a placeholder page for Wendy Engng, which means this person is not currently on this site. We do suggest using the tools below to find Wendy Engng.
You are visiting the placeholder page for Wendy Engng. This page is here because someone used our placeholder utility to look for Wendy Engng. We created this page automatically in hopes Wendy Engng would find it. If you are not Wendy Engng, but are an alumni of Hillsdale High School San Mateo, CA, register on this site for free now.


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Be Unique. Shop gun viographicce posters and art prints created by independent artists from around the globe. We print the highest quality gun viographicce posters and art prints on the internet.14.03.2018 Thousands of students across the United States walked out of clgraphic Wednesday to demand stricter gun laws in a historic show of political solidarity that was part tribute and part protest.


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L'Alfa Romeo 1900 C52 "Disco Volante", communément appelée l'Alfa Romeo Disco Volante ("La Soucoupe Volante" en italien), est une série expérimentale de voitures de sport et de course produites en 1952 et 1953 par le constructeur italien Alfa Romeo, en collaboration avec le carrossier Milanais Carrozzeria Touring. La voiture se distinguait par une carrosserie simplifiée, testée en soufflerie.

Trois "spiders" ou roadsters, biplaces découvertes, furent fabriqués en 1952, avec un moteur quatre cylindres 2 litres tout en alliage. Un an plus tard, l'un fut modifié en coupé, et un autre en spider plus classique. Deux autres exemplaires furent équipés d'un six cylindres de 3,5 litres, le moteur de la voiture de course Alfa Romeo 6C 3000 CM. Quatre des cinq voitures construites survivent aujourd'hui.

Histoire

La 1900 C52 fut développée en 1952 pour prendre part à des courses en catégorie sport, notamment aux 24 Heures du Mans où elle ne fut finalement pas engagée. Sa carrosserie aérodynamique enveloppante a été développée et construite en collaboration avec la Carrozzeria Touring, et testée en soufflerie. Étudiée pour obtenir un faible coefficient de traînée même dans des vents de travers, la carrosserie se caractérise par une section lenticulaire à la fois de face et de côté; le dessous étant aussi profilé.
Selon certains spécialistes, la conception de la Jaguar E-type a des aspects similaires à la Disco Volante.

Construite autour d'un nouveau châssis tubulaire à structure spatiale,
la Disco Volante utilisait les composants allégés de l'Alfa Romeo 1900. Comme sur la 1900, le moteur est un quatre cylindres en ligne à arbres à cames en tête entraînés par des double chaînes, mais le bloc est en aluminium et les manches sont insérées plutôt qu'en fonte. Alors que la course de la 1900, , fut retenue, l'alésage avait augmenté, passant de  à , ce qui porte la cylindrée totale à près de  cubes; le taux de compression a été augmenté à 8,73:1. Configuré de cette manière et alimenté par deux carburateurs double corps, le moteur produit 158 ch à 6500 tr/min. La boîte de vitesses manuelle synchronisée à quatre rapports est raccordée à un embrayage multidisque à sec. La suspension est, comme sur d'autres Alfa Romeo de l'époque, une double triangulation à l'avant et un essieu rigide relié au châssis par un haut triangle et deux bas longitudinaux de réaction. Les freins sont à tambours sur les quatre roues, et les pneus de 6.0×16" sont montés sur des roues à rayons avec jantes en duralumin.
Grâce à sa forme aérodynamique, la voiture peut atteindre une vitesse de pointe de .

Trois exemples de la Disco Volante deux litres ont été construits au total. En 1953, deux d'entre eux ont été modifiés afin de faire des tests aérodynamiques. L'un a reçu un toit fixe, devenant un coupé; l'autre, en faisant disparaître le caractère bombé des ailes en faveur de plus classiques, est nommé "fianchi stretti" (en italien "des hanches étroites").
La dernière voiture était la seule Disco Volante à être engagée dans quelques compétitions en 1953 puisque le programme n'a pas progressé au-delà du stade expérimental.

Deux autres voitures furent construites dans le style original, mais munies d'un moteur six-cylindres en ligne en fonte à double arbre à cames en tête provenant de la voiture de course contemporaine Alfa Romeo 6C 3000 CM; l'une fut démontée peu après. Avec une puissance de 227 ch () à , la Disco Volante de trois litres et demi pouvait atteindre les .

La Disco Volante aujourd'hui
Les prototypes spider et coupé deux litres sont préservés au Musée Alfa Romeo à Arese, et participent régulièrement à des courses d'ancètres. On estime la valeur de chacune entre un et deux millions d'euros. Le spider fianchi stretti est dans la collection Schlumpf, visible au Musée national de l'automobile de Mulhouse, France.
Finalement, l'unique spider six-cylindres de 3.5 litres restant est préservé au Museo Nazionale dell'Automobile de Turin.

Une sculpture en bronze inspirée par la Disco Volante a été révélé dans le parc des expositions Fiera Milano pour les 100 Ans d'Alfa Romeo à l'Été 2010.

Alfa Romeo Disco Volante par Touring

L' Alfa Romeo Disco Volante by Touring est un coupé deux places à moteur avant-central et transmission transaxe. L'Alfa Romeo 8C Competizione fournit le châssis roulant ainsi que la transmission et les systèmes électroniques. La voiture a été présentée au salon de Genève 2012 comme modèle de style. Touring la propose en série très limitée pour les clients les plus exigeants: des collectionneurs, des pilotes sportifs et des aficionados de la conception. Le modèle s'inspire de l'Alfa Romeo C52 de 1952.

Références

Coupé
Roadster
Voiture de sport
Automobile Alfa Romeo
Prototype d'automobile
Disco Volante

redpajama_set_name: RedPajamaWikipedia


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The next milestones in generating artificial organs
(Nanowerk News) What is the ultimate goal of research using human pluripotent stem cells? In the context of regenerative medicine, I think it's to recreate whole, replaceable organs in a laboratory setting. Transplanting these organoids could improve many treatment options. For instance, in the case of kidney damage, where patients must currently undergo dialysis for the remainder of their lives or until a donor organ is available.
Today, organoids are essentially miniature organs developed from stem cells and cultured on 3D frameworks, where they self-organize into functional tissue. These can partially replicate what cells within certain organs do. However, the largest organoids available today are only a few millimeters across. Once we discover how to grow them at scales comparable to real organs, we could create artificial organs derived from a patient's own stem cells.
The technology is also poised to accelerate drug discovery. Emerging 'organ-on-a-chip' devices—in which various cells are placed on a transparent microchip and connected through hollow channels—simulate the activities and cell interactions of an organ or organ system. Using these, it's possible to screen potential drugs using a cell system that more closely resembles the human body than 2D cell cultures or animal models. The enhanced efficiency should help cut costs in drug development, making treatments more accessible.
Historically speaking, RIKEN researchers were the first to demonstrate that cultured cells could self-organize into 3D tissues, first with cerebral cortical tissue in 2008, and then with cells from the optic cup, which is a part of the back of the eye, in 2011. We've continued to build on these groundbreaking findings at the RIKEN Center for Biosystems Dynamics Research (BDR), and are working to take the technology further through the Organoid Project.
A 3D organoid culture of human colon cancer. These organoids could help researchers understand the molecules and mechanisms involved in tumor formation to fine tune the response of individual cancers to treatment. (Image: Science Photo Library)
The organoid project
We're entering an era where developmental biologists alone can't solve forthcoming organoid challenges. The Organoid Project is a consortium that brings together RIKEN researchers and external collaborators to tackle organoid challenges and find real-world applications. In addition to developmental biologists, the Organoid Project includes researchers and technicians with expertise in areas such as microdevices, 3D printing, biomaterials and bioinformatics. This positions us uniquely to become a world-class base for generating organs in 3D.
Research under the Organoid Project spans the four key phases that take us from basic research to real-world applications: research on the self-organization mechanisms in stem cells; designing organoids; long-term culture and maturation; and optimization for applications.
Developmental biologist Mitsuru Morimoto and I work on the earlier phases of this process at RIKEN's Kobe campus. Here, Morimoto's team has succeeded in developing human lung alveoli organoids in the lab, which are now being used to model and develop treatments for lung diseases, such as pulmonary fibrosis, a scarring of the lungs.
His team has also elucidated the cell–cell communication signaling in the foregut, the top end of the esophagus, the stomach, and a portion of the duodenum, which is the embryonic origin of the trachea and esophagus. They have used these findings to develop tracheal cartilage tissue from human pluripotent cells. His group is now collaborating with the Center for Stem Cell and Organoid Medicine (CuSTOM) at Cincinnati Children's Hospital Medical Center in the United States to create a multiple organoid system that replicates the respiratory organs and esophagus.
Meanwhile, my team has established a method for generating kidney and bladder organoids from human induced pluripotent (iPS) cells. The kidney organoids have all the components of a nephron, the functional unit of the kidney. The bladder organoids exhibit a barrier function that holds urine in a way similar to the bladder, and we have also been able to replicate the muscle layers surrounding the bladder, which help hold and release urine.
However, a new frontier for organ regeneration is to replicate entire organ systems instead of standalone organs. From a surgical point of view, transplanting a whole urinary tract system instead of a kidney organoid alone could increase the likelihood of a transplant being successful. My team is working to connect organoids of the kidney, bladder and ureter, which connect the kidneys to the urinary bladder, to replicate the urinary system.
A challenge is that the urinary system connects organs, tissues and cells derived from two of three types of cell layers, called germ layers, formed in the third week of human embryonic development. The relevant cells here are from the endoderm—which develop into the inner linings of the body, such as the digestive system and bladder—and from the mesoderm, which develop into the kidney, muscles, and red and white blood cells, among other things. The connections at the kidneys and bladder are a rare point where these two types of tissues connect, and replicating this connection would be a major feat.
Research by Takashi Tsuji of RIKEN BDR and Masayo Takahashi—formerly at RIKEN and now an external collaborator at Kobe City Eye Hospital—is closer to real-world applications. Tsuji's team has developed a groundbreaking method, called the organ germ method, which uses organ-inducing epithelial and mesenchymal stem cells to replicate organogenesis, which is the growth and differentiation of tissues into organs during embryo development. In mice, his team has succeeded using this method to regenerate fully functional teeth, hair follicles and the salivary and lacrimal glands.
Using pluripotent stem cells, Tsuji's team has also generated organoids of the pituitary gland, salivary gland and 3D integumentary system, a skin system that includes hair follicles and sebaceous glands. He is now focusing on bringing the functional regeneration of teeth and hair follicles to world-first human clinical trials.
Meanwhile, Masayo Takahashi and her team at the Kobe Eye Center have begun clinical research on retina organoid transplants, in particular on optimizing organoids for transplant and assessing organoid quality. Retina organoids come as a flat sheet, and a challenge is to ensure that they include a robust layer of photoreceptors. Previously, Takahashi's team found that treating iPS cells with valproic acid helped yield retina organoids with sufficient photoreceptors. Achieving this, however, is dependent on the skill of the technician. Currently, the quality of an organoid can only be assessed by slicing and examining a cross-section. Takahashi and her team are now developing a technique that combines robotics and AI to achieve consistent quality, and to monitor the quality in processing.
Early-career researchers working on the Organoid Project at RIKEN BDR have also been working on cutting edge discoveries. In Kobe, Hidetoshi Masumoto, for instance, has discovered a way of applying mechanical energy to iPS-derived heart tissue, which will hopefully make it behave in similar ways to real heart tissue; while working at RIKEN, Cody Kime developed synthetic embryos that should help us understand early development in the human body; and Hideya Sakaguchi, also based in Kobe, has generated organoids of the hippocampus, the area of the brain associated with memory.
Minoru Takasato's team has established a method for using human induced pluripotent cells to generate kidney organoids (pictured) that have all the components of a nephron, the functional unit of the kidney. (Image: Minoru Takasato)
Core challenges
One of the challenges that remains is how to culture organoids for extended periods of time and to allow them to mature.
Organoids can be categorized into two major types: those made from adult stem cells, and those from embryonic stem (ES) cells/iPS cells. Adult stem cells are found in organs, such as the intestines or the stomach, where there is a high turnover of cells. They generate new cells throughout adult life and replace old ones in the lining of these organs. By extracting stem cells from a given organ, it's possible to generate organoids that resemble the functionality of adult organs.
In contrast, organoids made from ES/iPS cells replicate organs in the earliest stage of human development, in the embryo or fetus. In the real world, babies mature in the womb for nine months before being born, but the organoids we create are often comprised of cells at just a few weeks to several months into development.
This means that replicating the entire developmental process with ES/iPS-derived organoids would take just as long. And the question remains—how can we culture organoids in 3D for such an extended period of time? Establishing methods to run blood vessels through organoids could be a game-changer for this, as they would deliver essential nutrients and oxygen over long periods.
But how do we develop blood vessels on organoids? How do we control maturity level and size? How do we consistently create high-quality organoids that function the way they should? These questions must be overcome for organoid technology to be applied more widely. Today, organs have a sophisticated beauty that we can't yet capture in organoids, but modeling that complexity in its fullness is something the researchers behind the Organoid Project hope to achieve.
Source: RIKEN
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Synthetic genetic circuits reprogram plant roots
Even good gene edits can go bad
Scientists manufacture 'living blood vessel'
Gene activity in a test tube
Scientists develop method with single-molecule precision to engineer enzyme 'stickiness'
Researchers develop system for generating oxygen within cells
Utilizing chemo-mechanical oscillations to mimic protocell behavior in manufactured microcapsules
RNA origami enables applications in synthetic biology
New RNA-based tool can illuminate brain circuits, edit specific cells
'Game-changing' study offers a powerful computer-modeling approach to cell simulations
Algae as microscopic biorefineries
Scientists use modified silk proteins to create new nonstick surfaces
Researchers grow macroscale, modular materials from bacteria
Soft devices - powered by 'stressed' algae - glow in the dark when squished or stretched (w/video)
Researchers advance efforts to tailor drug delivery to cells' 'power plants'
Scientists imbue cells with 'noncanonical' pathway to make own drugs
...more biotech news


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Q: Python. Скачать видео с сайта доступное для авторизованного пользователя Ребят, привет.
Подвернулась мелкая работёнка.
Нужно было спарсить сайт, залогиниться на нём и скачать видео со страниц.
Спарсить - спарсил, залогиниться - залогинился, получил ссылку на скачивание.
Но как скачать её, не знаю, с таким не сталкивался. Подскажите, куда копать и что юзать.
В общем сайт на протоколе https.
Авторизацию на сайте прохожу, вот так.
s = requests.Session()

def login():
    s.get(HOST, proxies=PROXY_DICT)

    data = {'username': LOGIN,
            'pass': PASS,
            'remember_me': 1,
            'action': 'login',
            'email_link': ELINK
            }

    r = s.post(HOST_AJAX_LOGIN, data=data, proxies=PROXY_DICT)

    return r

Весь парсинг проходит с помощью сессии "s", для получение ссылок доступных только для авторизованных пользователей.
Так-же, нужно использоваться прокси, так как сайт из моего города, увы не доступен.
Дело в том, что получив ссылку на скачивание, она не доступна для скачивания в других программах или с браузера. Каждый раз есть небольшое, на 5 знаков, отличие в ссылке. Пусть и опыта у меня нет, я предположил, что ссылка дается именно на эту сессию (или все дело в куках?).
Соотвественно, для скачивания нужно эту сессию же и использовать.
В общем, ребят. Помогите разобраться с вопросом) А то даже не знаю куда смотреть)
P.S. Пробовал сделать так (тупо), но, никакой реакции. Программа просто бесконечно пытается получить файл.
 f = open(r'file.mp4', "wb")
 ufr = s.get(url, proxies=PROXY_DICT)
 f.write(ufr.content)
 f.close()

A: К сожалению, не имею возможности проверить свою догадку, но подозреваю, что видео отдается вам в качестве потока данных. То есть, это не цельный файл одним куском, а небольшие кусочки, посылаемые поочереди через промежутки времени.
Пример работы с такими данными есть в документации Requests.
В вашем случае, возможно, код должен быть таким:
resp = requests.get(r'https://addr/to/vidoe.mp4', stream=True)

with open(r'file.mp4', "wb") as output:
    for buf in resp.iter_lines():
        if buf:
            output.write(buf)

redpajama_set_name: RedPajamaStackExchange


During the past 50 years, pharmaceutical coating has gone through the transition from sugar coating to organic solvent coating and aqueous coating. Since the 1990s, aqueous coating has largely phased out organic solvent coating as the dominate coating method for pharmaceutical dosage forms due to the toxicity and environmental related concerns caused by the organic solvents. On the other hand, although prevailing, aqueous coating has other major limitations such as higher energy consumption and longer processing time than the solvent coating. Powder coating has the benefits of both, being environmentally friendly, energy efficient and short processing time, while equally effective in modifying drug release profiles. Consequently, powder coating is pointing to the future as the next breakthrough in pharmaceutical coating.
Involving three steps including preheating of the dosage forms, electrostatic deposition of coating powders and film formation (curing), powder coating has been studied to tablet coating with easily coated polymers. The objectives of the present study are to expand powder coating to more difficult coating materials such as ethylcellulose and cellulose acetate, as well as more difficult dosage forms including small pellets, and in particular, osmotic controlled release tablets.
As a water-insoluble polymer, ethylcellulose (EC) is a commonly used coating material for sustained drug release. However, it is very difficult to coat by powder coating due to its high glass transition temperature (Tg). The present study was successful to coat tablets with fine particles of EC in a rotatable pan coater. With the proper addition of plasticizers, a continuous and uniform coating film was formed. Pore forming agent was added in the coating formulation to adjust the permeability of the coating film to allow a more controlled drug release rate.
Currently, small pellets are coated by solvent coating or aqueous coating in a fluidized bed with a larger amount of fluidizing hot air than a pan coater, leading to an extremely high energy consumption. The present study utilized the pan coater instead of a fluidized bed to coat small pellets with powder coating, leading to a significant energy savings by avoiding the use of large amount of fluidizing hot air required to fluidize those pellets and to evaporate the organic solvent or water. Three different coating formulations containing Eudragit® EPO, Eudragit® RS/RL and Acryl EZE were developed to achieve immediate release, sustained release and delayed release, respectively.
Particularly, as the only oral drug delivery system capable of achieving constant drug release rate, osmotic drug delivery system (ODDS) is considered as the ultimate ideal drug delivery system. However, only organic solvent coating can be currently used to coat ODDS due to the high Tg of the coating materials. The present study successfully applied powder coating to coat ODDS with cellulose acetate (CA), resulting in a continuous, uniform and functionally acceptable coating film. Both elementary and porosity ODDS were achieved by using this powder coating. Following zero order drug release kinetics, drug release rate from powder coated ODDS varied with different coating levels while was independent with other factors such as drug delivery orifice diameter, pH vale of the release media and agitation speed. Considering that ODDS is the most promising controlled drug release system, the success of powder coating ODDS is a big breakthrough in pharma coating.
To fully illustrate the powder coating process, in-depth characterization was carried out to investigate the coating powder deposition and film formation, and their influence factors. Positively related to the coating efficiency, powder deposition was found to be the key of the whole process, which can be promoted by preheating the dosage forms, spraying suitable liquid plasticizer and applying electrostatics for the powder spray. A curing step is necessary after coating powder adhesion to allow deposited particles to coalesce and form a continuous coating film. Finer coating powders, higher curing temperature and longer curing time would lead to a more uniform and smoother coating film.
Yang, Qingliang, "Powder Coating for Pharmaceutical Solid Dosage Forms" (2016). Electronic Thesis and Dissertation Repository. 3964.


text:
Local Youth Engagement
Crewe Local Youth Engagement Project
Ada Re-imagined
Letter to Ada
Kirsty Bunting is a Senior Lecturer in English Literature at Manchester Metropolitan University Cheshire, with teaching and research publication specialisms in nineteenth and twentieth century women's writing and literary, social and political relationships. She is particularly interested in ideas of literary collaborations and networks, which informed the subject of her PhD (University of Birmingham, 2008). Kirsty has a secondary specialism in Early Modern Drama (MA Shakespeare Studies,The Shakespeare Institute, 2002).
Kirsty co-organised the Victorian Popular Fiction Association's 6th annual conference in 2014, on the topic of 'Victorian Treasures and Trash' (Institute of English Studies, Senate House, 8-10th July), and was faculty coordinator of the 2014 'Cheshire Lecture Series' at MMU Cheshire.
Kirsty is a member of Crewe Town Council's Arts and Culture Working Group which meets regularly with the aim of developing civic pride through involving the community in heritage, arts, culture and leisure activities and events.
Kirsty was voted 'best supervisor' in the 2014 MMU Students' Union Awards, is subject leader for the English undergraduate BA dissertation unit, and supervises and examines Masters by Research degrees on a range of literary topics.
Orlagh McCabe is a Senior Lecturer and Subject and Programme leader in Childhood and Youth studies at Manchester Metropolitan University Cheshire. Orlagh has worked in Widening participation for over fifteen years and is passionate about young people's rights, participation, transition and inclusion in various contexts.
Orlagh is faculty Widening Participation champion and has a number of community roles including chair of the 'Crewe Pledge' education group. The Crewe Pledge was established as an impartial initiative to support the transitions and aspirations of young people locally. Partners include all Crewe based schools, Reaseheath and South Cheshire College, Manchester Metropolitan University, Crewe Town Council, Cheshire East Council, South Cheshire chamber of Commerce and over 60 local business and employers.
Orlagh is a senior fellow of the Higher Education Academy and her research interests include learning transitions to HE and the use of web based technologies in teaching practices. Orlagh was recently nominated for 'Best Overall Lecturer' in the MMUNION teaching awards. She has been involved in a number of programme review and validation events externally and is currently an external examiner at Bangor University.
Copyright © 2022 · Designed and Hosted by Nic Bunting


BORIS JOHNSON is to renounce his American citizenship, at last putting a limit on his ambition.
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The London mayor has revealed that he wants to give up his dual nationality and hand back the American passport which he became entitled to when he was born in New York.
In an interview with The Sunday Times, Johnson said he wanted to make clear that his loyalty was to Britain rather than the country of his birth.


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Bosnia collapsed in upon itself, but the violence in Kosovo could ignite the Balkans beyond the former Yugoslavia. The guerrilla terrorism and state massacres of the past week are finally forcing American and European officials to take the danger seriously. When top diplomats from the United States and five European nations meet in London tomorrow, they should affirm Secretary of State Madeleine Albright's strong warning yesterday to the Yugoslav President, Slobodan Milosevic, to stop the killings of Kosovo's Albanians.
Kosovo is a province of Serbia with a population that is 90 percent ethnic Albanian. Until Mr. Milosevic came to power in Yugoslavia in 1989, Kosovo governed itself. Since then, its Albanians have lived in a police state, trying unsuccessfully to win their rights largely through nonviolent means. Lately, a small group calling itself the Kosovo Liberation Army has turned to bombings and killings. Serbian forces have responded by stepping up their own terror and murdering civilians.
If violence increases, Kosovo's conflict could spread to neighboring Macedonia, which has an Albanian minority. Since many of Macedonia's neighbors have territorial claims on it, chaos in Macedonia could encourage Albania, Bulgaria, Greece and Turkey to join a war.
Leaders in Washington and Europe have been talking about the danger for years. But even the Clinton Administration, which has contributed the most to maintain the peace, is not doing enough. Until Ms. Albright's comments yesterday, Washington had refrained from reiterating its strong warnings about the costs of Serbian military intervention in Kosovo. Negotiations have been left largely in the care of well-intentioned citizens' groups. But the Kosovo Albanians need Washington's help to insure that they are taken seriously.
The international community should remind the Kosovo Albanians that the world will not undermine the goal of multi-ethnic nations by supporting an independent Kosovo. A better choice is restoration of the self-governing status Kosovo held before 1989. The world must also work to cut off any arms or money flowing to the guerrilla group from Albania or groups in countries such as Germany.
The more urgent job will be persuading Mr. Milosevic, who began his drive for power in Yugoslavia with nationalist exhortations about Kosovo, to relax his grip. It will require unified pressure. The diplomats meeting tomorrow should begin by adopting Washington's proposal that the events of the last week be thoroughly investigated.
Russia, Greece, Italy and Britain should stop their trade with Belgrade, which has helped Mr. Milosevic stave off a foreign-exchange crisis and allowed him to maintain the patronage networks that keep him in power. If Russia is not willing to stop its sales of oil and arms, it should at least demand cash instead of barter from Serbia. Mr. Milosevic keeps Serbian and possibly personal bank accounts abroad, many reportedly in Cyprus. These should be frozen. To reinforce the message, the top diplomats of all NATO nations should make clear that Mr. Milosevic's defiance in Kosovo is being closely watched and is of great concern to them.


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Select destination from earlier usage.
After indicating to the system that we intend to write a referral, the system shows the referral destinations we've1 used earlier for the same problem type.
Recommendations for particular referral destinations show as tooltips.
Resting the mouse pointer over any referral destination causes the system to show a tooltip with instructions and information that the referred-to department wishes the referrer to take into consideration. The great advantage is that these instructions and tips are presented at the right place and at the right time, when they are most likely to be useful.
You can always select any type of referral when needed.
If the user needs a referral that isn't presented in the list, they can select "other", which results in a full list of all the receivers available in the system. Instructions and tips can be shown in this case as well2.
Once you've chosen a referral, you're presented with a classic referral form. You can fill out the fields manually, or you can, for each field, choose from a set of preselections which can, if desired, be modified to suit the particular case. In any case, the contents of the fields will be saved for later reuse by you3 for later cases. The more frequently you use certain phrases, the higher they will place in the selection list. You can reach the preselected phrases by clicking the button with the ellipses4 to the right of each field.
Select history descriptions from earlier usages.
If the user clicks the button to the right of the history field, they will be presented with a list to choose from of phrases that have been used for this field and this kind of referral in earlier cases.
Select status from earlier usage.
Choosing phrases for the status field is entirely analogous.
Choosing attachments works differently. It would make no sense to choose the same attachments as in previous cases, but it does make sense to choose the same kind of attachments. Usually one would choose "the latest" of either lab, notes, or responses to referrals.
The type of referrals listed are collected from the peer group of the doctor, so referral habits become distributed within the group.
Please don't take my examples too seriously. It's just little more than a word salad.
There's a risk of information leakage if you share these phrases with other users, so for referrals, the phrases are only presented to the same user when managing later patient cases.
I'm not a talented button designer.


With Sibos exhibitor day just over two weeks away, this video looks back at some of our work from Sibos 2016.
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Trump said on Friday that the Federal Reserve made a mistake by raising interest rates.
Prior administrations have taken care not to comment on Fed policy, but Trump has railed repeatedly against the U.S. central bank's rate hikes.
WASHINGTON/NEW YORK: U.S. President Donald Trump said on Friday that the Federal Reserve made a mistake by raising interest rates and blamed the central bank for hurting the U.S. economy and stock market.
"Had the Fed not mistakenly raised interest rates, especially since there is very little inflation, and had they not done the ridiculously timed quantitative tightening, the 3.0 percent GDP, & Stock Market, would have both been much higher & World Markets would be in a better place!," Trump tweeted.
The remarks were part of a new attack the White House has launched against the independent central bank in their unusual public split. The Fed's Board of Governors did not immediately comment.
Prior administrations have taken care not to comment on Fed policy, but Trump has railed repeatedly against the U.S. central bank's rate hikes. Friday's comments were uniquely specific about the course of action now favored by the president.
The president's top economic adviser said the White House would like the Fed to reverse some recent rate hikes and stop shrinking its bond holdings to protect the U.S. economy from weakness overseas. Some Fed policymakers and other economists have credited U.S.-China trade tensions or tariffs under the current administration as a factor behind the slowdown and market swings.
"This is our view. This is his view. This is my view," National Economic Council Director Larry Kudlow told CNBC on Friday, confirming that he had told news website Axios that he would like the Fed to cut rates by a half-percentage point and stop cutting its bond holdings.
"The Federal Reserve is an independent central bank. They're going to do what they're going to do."
He told Fox News that he would consider reversing the Fed's December interest rate hike but said he was not necessarily in favor of the half-point rate cut recommended by Kudlow. Moore was quoted as saying he favored such a cut by the New York Times on Tuesday.
"He's our chairman. We're not going to displace him."


text:
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 Bieg na 60 metrów przez płotki (hala) – 8,13 (2012) były rekord Bahamów
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text:
IQ-EQ shortlisted across three categories in 2021 Citywealth IFC Awards
IQ-EQ has been named as a finalist for two regional awards in the Citywealth International Financial Centre Awards for the second year running. In addition, Jersey-based private wealth director Clare Crockart is in the running for 'Trustee of the Year – Channel Islands and Isle of Man'.
These high-profile awards were established to highlight excellence among the advisers and managers in the private wealth sector across the world's major international financial centres.
IQ-EQ is up for the title of 'Trust Company of the Year' for both Hong Kong & Singapore and Guernsey for the second consecutive year. Having taken home the crown for our Hong Kong and Singapore offices in the 2020 awards, here's hoping we can retain and add to this title in 2021!
These nominations come hot on the heels of IQ-EQ being crowned 'Trust Company of the Year (large firm)' in the industry-leading STEP Private Client Awards earlier this month and are further testament to the strength of our global Private Wealth service offering and hard-working teams.
Meanwhile, Clare Crockart's individual nomination recognises her talent and depth of experience as a trustee and her stellar reputation among clients. With over three decades in the fiduciary industry, Clare is an expert private client practitioner and enjoys working closely with ultra-high-net-worth individuals and families based all around the world.
Voting is now open to determine the winners of the 2021 awards, which will be revealed at the awards ceremony in February.


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text:
Shirley Leung
Tower project might cast shadow on Boston development
By Shirley Leung Globe Staff,January 4, 2017, 8:59 p.m.
The tower at Winthrop Square proposed by Millennium Partners.Handel Architects
Let me get this straight. Millennium Partners proposes a billion-dollar redevelopment of the shuttered Winthrop Square garage and then forgets to check whether the project might violate the state's shadow laws?
That's the policy that prevents new skyscrapers from casting long shadows for prolonged periods on the Boston Common and Public Garden.
Keep in mind, Millennium has built in this town before. Just up the street, in fact, from the city-owned garage, with a trio of projects in Downtown Crossing — a spectacular tower on the old Filene's site, Millennium Place condos, and the Ritz Carlton.
"It was counterintuitive for us to think a location substantially further away from the Public Garden or the Common would have more stringent rules," Millennium Partners principal Joe Larkin tells me. "I am glad we figured it out when we did."
Yes, this is the same firm behind the "Leaning Tower of San Francisco," a 58-story luxury building that is sinking — so far, 16 inches — amid the soft soil of that city.
I bring this all up because the shadow laws — and whether one developer deserves an exemption — will almost certainly be a hot topic at a public meeting Thursday on the Winthrop Square project.
Millennium claims it only figured out that it would run afoul of these laws in August, shortly after the city of Boston selected it as the leading candidate to redevelop the garage. The firm had bested five other bidders in a process that has dragged on for more than a decade.
Millennium discovered the problem as it was reviewing whether its proposed tower — which could rise as high as 775 feet, or about 55 stories — would get clearance from the Federal Aviation Administration, which monitors whether new buildings will interfere with Logan flight paths.
Larkin said the firm's analysis found that any project taller than 365 feet would violate the shadow ordinance. All six proposals for Winthrop Square exceeded that height.
Millennium's proposal, according to the developer's analysis, would be out of compliance on average about 36 minutes a day over the course of a year on the Common and on average about five minutes a day over the course of a year on the Garden.
That doesn't sound like a big deal until you talk to park advocates. The state shadow laws were passed to protect the horticulture in public parks.
"You can correct for water with irrigation. You can correct for nutrients with fertilizer," said Liz Vizza, executive director of the Friends of the Public Garden. "You cannot correct when you lose light."
But to Vizza, the laws are not just about the tulips, but the ability of thousands of people to enjoy the civic right of sunshine.
"It's important for us to realize it's as much about the humans as it is about the horticulture," she said.
With the monumental task of needing an act of the Legislature to approve an exemption, did Millennium think its project was dead?
"We didn't think it was over," Larkin said. "We actually think the benefits of this project are clear. We hope the community agrees, and the city agrees."
Oh, the city agrees, and it is going to bat in a big way for Millennium by seeking the exemption from city councilors and state lawmakers. Mayor Marty Walsh has been trumpeting how the bulk of the proceeds from the $153 million deal for the garage will help Boston parks, including $28 million for the Common.
City officials claim they didn't realize the magnitude of the shadows until Millennium informed them in August. It seems that absolutely nobody in City Hall could remember that the issue surfaced a decade ago when developer Steve Belkin unsuccessfully proposed a 1,000-foot tower on the garage site.
This all feels like some tall tales being spun by Millennium and City Hall to justify a Hail Mary attempt to salvage the long-suffering garage project. The truth is that the city should have conducted a robust discussion years ago on whether shadow laws should be changed to accommodate a tall tower in Winthrop Square.
I get why the city didn't want to go there. It can be hard to calculate shadows without a building design. Shadow studies also cost a lot of money; better to shift that expense to the developer.
But by waiting until now, the City Council and Legislature must make amendments under pressure from Walsh, who wants the city to collect on a lucrative package. That's never a good way to craft legislation.
The shadow laws, written in the early 1990s, have served the city well and remained intact through several building booms. The irony about asking for an exception to the rule is that the Winthrop project might get it, but at the cost of other development.
How so? By reopening the laws, I can see an effort to make the shadow laws more restrictive, such as covering a broader swath of Boston.
That's something State Representative Byron Rushing, who coauthored the original bill, has been itching to do.
"We should take a look at the larger issue" of downtown open space, Rushing said. "If we do that, it might be easier to incorporate this tower's silhouette."
In the end, Walsh might get his way to have Millennium build sky-high on Winthrop Square. But the price might come at the cost of future development in Boston.
Millennium Partners created two shadows studies. Arrow A, above, shows the effect on the Public Garden, Arrow B, below, the effect on Boston Common.
Shirley Leung can be reached at shirley.leung@globe.com and on Twitter @leung.


We would all like to think that we're above such mundane things as looks and presentation, but the fact is, appearances count — a lot. The good news is that this doesn't necessarily mean that we have to be supermodels to get ahead.
Although attractive people sometimes have an easier time getting promotions and raises (and sometimes don't) the really important aspect of your appearance at work has to do with how you dress and carry yourself, not how your features are arranged.
Ouch. Painful as that was to hear, though, her manager probably did her a favor. (Provided, of course, that her criticism was constructive and professional and didn't cross a line.) So how can you make appearance work in your favor?
1. Look at how everyone else is dressed.
What's appropriate for one job might be either too casual or too stuffy for another. Some workplaces are very traditional; others are freewheeling and anything-goes. If you're a woman working in a field that's mostly populated with men, your managers might advise you to dress conservatively — and even if it makes you grit your teeth to have to adapt your style in order to be accorded the respect you deserve, it's probably good advice.
2. Dress for the job you want.
It's a cliche at this point, but it's still true. If you dress like an intern, you're not going to become the boss anytime soon.
No matter what you wear, make sure it's clean and pressed. And before you do that, make sure you're clean and pressed, too. Even the most casual dress code is no excuse for being a bad work neighbor.
What's your company's dress code like? We want to hear from you! Leave a comment or join the discussion on Twitter.
Bachelor's Degrees: Just What Are They Worth?


We've had a pretty mild winter here in Colorado so far, and we were even spared the wrath of the Polar Vortex 2019. As for the Midwest, well, even antifreeze is freezing.
So for now, we'll just scrape our ice and soak up our sunshine here in Colorado and count our blessings. We will have temps in the mid-50s through Sunday (yay!).


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ALLY YOUNG
THE WEST AND OTHER MISTAKES
DIDDIE WA DIDDIE
Ally has a BA in English Literature and Visual Arts from Kenyon College, where she was the recipient of an Academy of American Poets Prize, a John Crowe Ransom Prize in Poetry, and The Mary Hatcher Prize for Women's and Gender Studies. She has an MFA in Poetry from Syracuse University, where she worked as Editor in Chief at Salt Hill and taught undergraduate writing. She has taught at Creative Action in Austin, Texas, The Putney School Summer Arts Programs, in Putney Vermont, at Syracuse University, and elsewhere. She currently teaches Undergraduate Writing and instructs creative writing workshops in New York and Jersey City.


a free socail network with a basic setup where you can come and meet new people and enjoy a fun and safe enviroment and enjoy many free features.
ittleBiggy is a people guide; a constantly evolving, personally-written, fully-attributable online library of humanity. it is a place to communicate with each other.


Starting to look at the detailed planning for our upcoming trip to Berlin. Family of 4 (kids 13 & 10) staying 5 nights at the Novotel Berlin Mitte.
We arrive Thursday evening (28 Mar) before Easter from the UK (no jet lag). I like to have a plan but also adapt as necessary.
Aim for early reservation to Reichstag and then start walking through the various memorials where we'd like to spend more time than we got on the walking tour. Reichstag, Memorial to the Murdered Jews and Topography of Terror will get priority.
Original Berlin Walks tour to Sachenhausen. E-mail to confirm it's still a go on Easter.
Looks like I will have to save the Zoo, Berlin Wall Memorial, and Jewish Museum (and others) for another time.
glad to see that the Deutscheshistorischesmuseum is on your itinerary - one of the best we've ever been to anywhere, but that may be because of the exhibitions that it had on at the time we were there of course.
what you may also enjoy is the area around the Fischerinsel -[ where you are staying] which is a canal area with little bars and cafes, and the Nicolaiviertel [viertel = area] across the river -the walk around that area is interesting as is the 1 hour boat trip that you can do around the centre.
wonderful views over the city and a great revolving restaurant which your kids would love- reservations required though.
i can absolutely promise you that you won't run out of things to do !
You need to be aware that Good Friday, Easter Sunday and Easter Monday are all holidays, and things may be closed. Friday is considered a "quiet" day, there will be very little public life.
Not sure if your itinerary for the 30th will keep you busy all day - even at a leisurly pace.
You may find time (and energy) to end your day at Wall memorial site, just a few stops by S-Bahn from Brandenburg Gate.
The Museum at Checkpoint Charlie will probably keep your kids entertained, but in general it is more a rather compact, or cramped museum with artefacts from often hilarious attempt to get across or over or under the wall. So you won't exactly get a "real" feeling for what the wall and death strip looked like there other then pictures. If you look for such, you should swap it for the Wall memorial site.
The boat trip which PP mentioned is a nice idea to see the sights of the Mitte district and get off your feet for an hour. If the weather plays along.
In general you should also keep an eye on the local TI website visitberlin.com so you won't miss any temporary exhibitions or activities which you might like.
Greenway mentioned a good point.
While most sights you mentioned should be open all holidays (with Good Friday being the possible exception), stores will be closed Easter Sunday and Monday.
Though neither Good Friday or the Easter days will effect restaurants, cafes, bars or pubs. As everybody in Germany got a long free weekend from Friday to Monday, and Berlin is also a hotspot for domestic tourism, you can expect a LOT of public life on either day. Except for shopping, which will only be possible on Saturday with the exception of the tourist/souvenir shops near the major sights.
Another vote here for the German History Tour. The audio is worth it too.
The walking tours are very good value for money although I'd steer clear of the "free" ones. They work for tips. The guides for the commercial operations are likely to be well informed.
The tiny inspection station on the street, and guards, are fake. Actors also set up for photos at Brandenburg although there is enough around there for an hour.
Berlin is a wonderful city for anyone with a curious mind, especially young teens who don't mind walking.
Thanks for the comments -- keep them coming.
I *think* most of the museums, public transportation, and hopefully restaurants are open. Shopping's not high on the list but it is good to know. I guess it may also curtail some options for picnic lunch preparations.
Decidedly mixed reviews from what I can tell. We'll play it by ear.
Thanks for the links, Southam. I've come across those previously, but it's a good reminder to review.
Thanks, annhig. Always appreciated. I haven't started thinking about those yet -- you've given me a good start.
food - always my starting point and specialist subject.
BTW - the Fernsehturm is worth seeing in its own right but the restaurant is the icing on the cake!
You can find the memorial to the bookburning at the Bebelplatz. You look through a plexiglass window into a room of empty shelves. It's simple but effective.
Public transport is up and running in Berlin 24/7, also on any holiday.
The "worst" will be that subways etc will be running on a sunday schedule Fri, Sun and Mon. Which means that on the line you are on (U2) you will have trains every 10 minutes instead of every 3-4 minutes.
If you need a supermarket on public holidays, those in stations Friedrichstraße, Hauptbahnhof and Ostbahnhof will be open.


The 9th edition of the Rugby World 2019 is to be held in Japan Starting from 20 September to 02 November. This is the first time tournament is going to be held in Asia. A total of 20 teams will play in this upcoming world cup. These Teams are divided in four pools named as Pool A, Pool B, Pool C and Pool D. Every pool contains 5 teams and total 48 matches will be played in this tournament. Pool A teams Japan and Russia have to play opening match at Tokyo Stadium, Tokyo.
The final match of this tournament will be played at International Stadium Yokohama. Rugby World Cup held after every 4 years, twenty nations will fight for the world cup in Japan. Round Robin format will be used for every pool where each team has to play against other teams in the pool.Top 2 teams of every pool will qualify for the quarter finals and the top 3 teams in every pool will automatically qualify for Rugby World Cup 2023. New Zealand is the defending champion of Rugby World Cup.
You can check rugby world cup 2019 fixtures here at official website.


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Home Healthy Living
Food Myth Debunked: Why MSG Chinese Food Criticisms Should Be Taken With A Grain Of Salt
Aug 26, 2014 02:18 PM By Lizette Borreli @lizcelineb l.borreli@medicaldaily.com
The American Chemical Society debunks a 50-year-old food myth, and explains why MSG criticisms should be taken with a grain of salt. Photo courtesy of Shutterstock
Most health-conscious consumers are aware of their food choices, especially when they opt to buy, cook, and eat monosodium glutamate (MSG)-free products. The food additive, popularly used in Chinese food, and found in canned vegetables and processed meats, has been given an undeserved reputation for causing "Chinese Food Syndrome": headaches, nausea, and heart palpitations, among other symptoms. While consumers and companies alike have decided to go MSG-free, scientists at the American Chemical Society's Reactions (ACS) YouTube page debunk this food myth and say MSG is perfectly safe for consumption.
"Glutamate is found in tons of common foods that are rich in protein — meat, dairy products, and vegetables all have glutamate," say the scientists in the YouTube video, "Is MSG Bad for You?" The flavor enhancement we taste in MSG foods comes from the amino acid, l-glutamate. Glutamate occurs naturally within our bodies as we process and metabolize food, making it a very abundant and very common part of our diet. The monosodium part in MSG is so we can easily sprinkle it on a dish.
Since the body makes this compound, it only makes sense to wonder where the 50-year-old myth originated from. According to the ACS, Robert Ho Man Kwok experienced "Chinese Restaurant Syndrome," a term coined in a letter to The New England Journal of Medicine. He experienced these symptoms after eating large amounts of Chinese food, which made his colleagues decide that MSG must be the culprit.
Fifty years later, human studies have failed to produce significant symptoms, including in those who claim to suffer. In an infographic by Compound Interest, it shows most criticisms of MSG contain anecdotal accounts, without scientific evidence to back them up. Therefore, scientists have concluded mild symptoms may occur in some individuals, but only if they consume large amounts of MSG on an empty stomach.
A rule of thumb: Take MSG criticisms with a grain of salt and consume responsibly.


February is a big month for Warner Bros., as both their Justice League: Crisis on Two Earths and Halo Legends animated films are released. Below the press release for the latter are 8 brand new pics from the anthology film, which is released on Feb 16.
Produced by 343 Industries, a part of Microsoft Game Studios, the exciting tales-beyond-the-games explore the origin and historical events of the Halo universe and its intriguing characters. Halo Legends has been created in the same breakthrough format as The Animatrix and Batman Gotham Knight with each individual episode imagined by a cutting-edge, renowned Japanese anime director/animator, including Shinji Aramaki, Mamoru Oshii, Hideki Futamura, Tomoki Kyoda and Yasushi Muraki. The stories are inspired and produced by the creative minds of 343 Industries, including Halo franchise development director Frank O'Connor and managing editor Kevin Grace.
The individual episodes fall within Halo's 26th Century mythology as the battle between humanity and aliens rages on in an attempt to protect Earth and mankind's expansive number of space colonies. The dramatic, action-packed stories feature characters and locales familiar to Halo fans, and episodes range in length between 10 and 17 minutes – resulting in nearly two hours of animated adventures.
(Appleseed), Hideki Futamura (The Animatrix), Daisuke Nishio (Dragonball Z), Hiroshi Yamazaki (Karas), Toshiyuki Kanno (Black Lagoon), Koichi Mashimo (Blade of the Immortal) and Koji Sawai (Patlabor); directors/action designers Tomoki Kyoda (Eureka Seven, Evangelion 1.0) and Yasushi Muraki (Macross Plus, Vampire Hunter D); and writer Dai Sato (Cowboy Bebop).
Halo is a centerpiece in the world of video games, selling more than 27 million units to a devoted legion of fans – including the latest hit Halo 3:ODST. The Halo franchise has driven more than $1 billion in revenue from its award winning Xbox games, New York Times best-selling novels and comics and a wide variety of other merchandise.
Of interest to you, the new Black Panther cartoon. I like it, it looks different. I like the honesty of staying true to the African roots thing.


You already know, for some purpose I used to be fairly satisfied that this child would come early. I don't know why, however I had it in my thoughts that we wouldn't fairly make it to 40 weeks and we'd be holding our little bundle in our arms already. Nicely, it seems that my hunch didn't truly imply a factor as a result of look the place we at the moment are. Glad due date, my little pricey! I can also't fairly wrap my head round the truth that that is the VERY LAST bumpdate! Let me fill you in on every little thing that's occurred in my final month of being pregnant throughout weeks 36-40, from recognizing labour indicators to an sudden hospital go to!
I've stated earlier than that this being pregnant felt prefer it was flying by within the blink of an eye fixed. Nicely, the final month of being pregnant has felt like an absolute ETERNITY. Every day drags on and on and on. I truthfully really feel just like the idea of time has no which means anymore, prefer it's groundhog day. I can't keep in mind what it's wish to not be pregnant now and it feels like this child gained't ever truly come out!
It's not a lot that I'm feeling bodily depressing – I can cope with the aches and pains and swelling and lack of sleep. I'm uncomfortable and drained however it's positive. It's extra of the emotional aspect of issues that I've been battling.
It's not that I'm anxious about delivery. Truly, that couldn't be farther from the reality. I'm so excited concerning the huge journey that will probably be. I really feel calm and ready and I belief that my physique and my child understand how to do that. I'm robust and wholesome and I do know that my physique is designed completely for this.
It's extra simply the ready recreation that's onerous now. As soon as I hit full-term at 37 weeks, I realised that the child might come at any time. 37 weeks isn't thought-about early. The child is absolutely developed and prepared for the world at this level. So I'd made positive that I used to be absolutely organised and ready by this stage. The hospital bag was packed, the nursery was completed and the freezer utterly stocked. Every thing was prepared for go-time.
However in fact, our little love was fairly cozy in there and stayed put. So I busied myself with including increasingly more gadgets to my 'issues to do earlier than child' guidelines, convincing myself that they have been very important duties that completely wanted to get accomplished. In actuality although, arranging my skincare by bottle measurement might be not that important, however hey.
For the primary time a number of weeks in the past, I stated to Ben that I lastly felt prepared for this being pregnant to be over. Up till that time, I used to be feeling fairly unhappy on the prospect of it ending since I beloved being pregnant a lot. Nevertheless it lastly hit some extent the place I simply needed this child in my arms greater than something on the planet. I couldn't get an honest night time's sleep for the lifetime of me and I used to be feeling so hormonal and emotional. The whole lot appeared like a superhuman effort once more prefer it did within the first trimester, even catching up with household and buddies. All I needed to do was hibernate, be alone and zone out.
Keep in mind how I used to be saying that the unique delivery photographer we'd booked had fallen by way of? Properly, I lastly discovered one other photographer who's type I liked. It took ages to seek out. However I'm so glad that we've locked in Kelly from Kelly Jordan Images to seize our child's start. She came to visit to satisfy us and chat about how it will all work. She's now on name for us for every time this little babe decides it's time to make an look!
The subsequent week, we headed again into the hospital for my 38 week appointment. It was a fast and straightforward checkup and all the things continues to be wanting nice. The infant continues to be posterior (no change there) and my blood strain was wonderful. Should you keep in mind in my final appointment, I took the Group B strep check and I used to be frightened that if it got here again constructive, we'd need to determine whether or not or to not go on antibiotics throughout labour. Fortunately although it had come again destructive so now we didn't have to fret. So good.
It actually felt like I used to be on the house stretch now. I might go into labour any minute, I assumed! I instantly felt the urge to get all my appointments ticked off. I booked in for a haircut, had a mani and pedi and even handled myself to an excellent being pregnant therapeutic massage. Now's the time to get pampered in any case – there gained't be a lot time for that when the little milk monster is hooked up 24/7!
So I do know you need to know if I've been having any labour indicators. Nicely, I really feel like I've been having indicators for weeks however there's no child but! I've been feeling numerous strain down there (the midwives hold telling me that child's head is so low) and I've been having random tightening emotions right here and there. Typically they really feel like interval ache down low and different occasions like a crampy sew throughout the highest of my stomach. Perhaps these are Braxton Hicks? I truthfully don't actually know.
On the night time of the seventh October once I was 39 weeks and a couple of days, I awakened within the night time feeling SO a lot pelvic strain. I might barely roll over in mattress, it was that uncomfortable. The next morning, I awakened and discovered I'd misplaced my mucous plug.
The subsequent day I had my 40-week midwife appointment, which was good timing. She stated that dropping my plug was an excellent step ahead and that each one the indicators have been pointing to the child being right here very quickly. I felt constructive and completely thought it will simply be a matter of days earlier than I went into labour. Properly, it's been virtually every week since that appointment and… I'm nonetheless very pregnant. I assume the child continues to be working up sufficient braveness to return out.
As regular, on this appointment I had my blood strain taken and, for the primary time in all the being pregnant, it was on the upper aspect. I used to be so shocked. Was this the beginning of pre-eclampsia that I'd examined high-risk for earlier in my being pregnant? To play it protected, I used to be requested to do a urine check to examine for protein in my urine (one other key indicator for pre-eclampsia). Fortunately although, it was damaging. The midwife took my blood strain once more in the direction of the top of the appointment and it was again to regular. Should have simply been a type of issues.
I used to be additionally booked in to see an OB the next week, in my 41st week, to speak about attainable induction steps if I don't find yourself going into labour spontaneously. As a result of by then I'll be post-date, they should monitor issues slightly extra intently too. I have to go in about an hour earlier than my appointment for CTG monitoring, simply to verify that the child continues to be doing properly in there. In order that's the plan for this week.
However… little did I realise that I'd be again on the hospital so quickly. Final Wednesday, I turned frightened that I hadn't felt the child transfer as a lot as traditional. I'd had my typical acupuncture session within the morning, which all the time triggers a number of motion, after which got here house for a day film marathon. I keep in mind feeling motion round 3pm however come 8pm, I couldn't keep in mind the final time I'd felt something. Often the infant is tremendous lively within the afternoons and evenings and makes the most important actions round this a part of the day. However there was an uncommon quietness that felt totally different.
I discussed it to Ben and I attempted to do all of the issues that often will get the child to maneuver – poking my stomach, consuming one thing candy and chilly and mendacity down. I DID really feel some little actions, nevertheless it simply didn't really feel robust like regular. I didn't need to take any possibilities that one thing is perhaps mistaken so I referred to as the hospital. The midwife stated that if at any time I felt like there have been decreased actions, I ought to are available for monitoring. So off we went to the hospital at about 10pm that night time.
Proper on cue although, as quickly as I used to be hooked as much as the screens, the child had one of many largest dance events within the historical past of its unborn life. It was prefer it was making an attempt to burst out of my stomach. All the things appeared good on the CTG however as a result of I used to be full-term, the midwife taking care of me stated that a physician wanted to do an ultrasound and to log off on every thing too. So in got here the OB with the scanner. She measured the fluid (a wholesome degree) and checked that the child was shifting and practising respiration. Fortunately, all appeared regular.
I need to admit that I felt slightly foolish after that as all of the testing confirmed a really wholesome and lively child however the midwife and physician each reassured me that I'd accomplished the proper factor. They stated to ALWAYS are available if one thing doesn't really feel proper as a result of if one thing had been flawed and I'd ignored it and went to mattress that night time, it may need been too late come morning. The OB additionally stated that though they will do all these exams and checks on the infant, an important factor is a mom's instinct they usually take that very critically. In order that was good to listen to and I'm actually glad I went in.
Whereas I knew I might very properly go into labour at any second, I additionally knew I'd in all probability really feel a bit down if nothing appeared to be occurring round my due date. I do know that in actuality, solely 5% of infants are born on their due dates however I used to be simply so hoping that this child could be as keen to satisfy us as we have been to satisfy them! It seems that I've made fairly a good, cosy and cozy residence in there although so no such luck. To really feel higher, I took myself off for a ravishing being pregnant therapeutic massage on my due date. It was so pretty.
So now all we will do is wait! I'm doing ALL the issues to attempt to convey on labour naturally – acupuncture, strolling, consuming curries, bouncing on my match ball, consuming buckets of raspberry leaf tea, doing deep squats, consuming handfuls of dates. You identify it and I'm doing it. Hopefully we don't get to the purpose the place I've to be induced however I do know that it's out of my palms now. This child will come precisely as he/she intends to and I've acquired to belief in that.
That brings us updated! Nicely, principally. As I sort this, I'm at present 40 weeks + 2 days. I'll be scheduling this submit forward so I've every part crossed (besides my legs) that I've the child by the point that is revealed. We'll see!
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How much CBD oil should I give my cat? If you've been considering trying CBD oil for your cat, you're probably wondering what dosage would be best. The good news is that there are no reports of cats overdosing on CBD oil alone as the excess CBD is excreted through the cat's waste (marijuana is another matter entirely). So, it's unlikely you'll give your cat too much.
What conditions might CBD oil help your cat with? How much CBD oil should you give? Let's talk about it.
CBD oil is generally dosed based on weight. You should start with the lowest dose and increase until you see results so you wind up using the lowest effective dosage. Using our brand Cannanine™ as an example, you would begin with giving increments starting with just filling the tapered tip for example up to 1/4 of the dropper, which is the recommended dosage for pets weighing 15 pounds. Stick with the increment for 5-7 days and then increase if you don't notice any positive effects (helpful tip: take a photo with your smart phone or another camera to reference the current increment you're giving your pet). If you don't notice any effects at 1/4 of a dropper you can increase to more but we'd recommend sticking to around a 1/2 dropper as that's the recommended dosage for a 30-pound pet. Every pet's body is different and these are just general guidelines! Remember, it is not possible to overdose with CBD as your cat's body will just release the excess in his or her waste.
To administer: You may have better results adding the oil to your cat's food or a treat rather than dropping the oil in their mouth.
Cannanine CBD Oil is non-GMO, made from human-grade ingredients, made from organic Colorado hemp, and is non-psychoactive, meaning it contains absolutely no high-causing THC. It's tested and found to be free of heavy metals, harmful bacteria, yeast, mold, and other toxins and features patented nano-sized microemulsion for maximum bioavailability and absorbability (4x smaller particles compared to liposomal emulsion).